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4D Pharma PLC

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FY2015 Annual Report · 4D Pharma PLC
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Registered No. 08840579 

Annual Report and Accounts 

For the year to 31 December 2015 

 
 
 
 
 
 
 
 
 
 
 
Contents 

Company Information 

Chairman and Chief Executive Officer’s Joint Review   

The Board 

Strategic Report   

Directors’ Report   

Corporate Governance Statement 

Report of the Remuneration Committee 

Independent Auditor’s Report 

Group Statement of Total Comprehensive Income 

Group Statement of Financial Position 

Company Statement of Financial Position 

Group Statement of Changes in Equity 

Company Statement of Changes in Equity 

Group Cash Flow Statement 

Company Cash Flow Statement 

Notes to the Financial Statements 

Notice of Annual General Meeting 

Notes to the Notice of Annual General Meeting 

Explanatory Notes to the Notice of Annual General Meeting 

2 

3 

6 

7 

9 

12 

15 

16 

17 

18 

19 

20 

21 

22 

23 

24 

43 

45 

47 

4D pharma plc Annual Report and Financial Statements 2015 

1 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Company Information 

Directors 

David Norwood 
Duncan Peyton 
Dr Alexander Stevenson 
Thomas Engelen   

(non-executive Chairman) 
(Chief Executive Officer) 
(Chief Scientific Officer) 
(non-executive director) 

Secretary 

Laurence Dale 

Nominated advisor and broker 

Auditor   

Registrar 

Registered office 

Zeus Capital Limited 
82 King Street 
Manchester M2 4WQ 

and 

41 Conduit Street 
London W1S 2YQ 

RSM UK Audit LLP 
3 Hardman Street 
Manchester M3 3HF 

Capita Asset Services 
The Registry 
34 Beckenham Road 
Beckenham Kent BR3 4TU 

Third Floor, 
9 Bond Court 
Leeds LS1 2JZ 

Website  

www.4dpharmaplc.com 

4D pharma plc Annual Report and Financial Statements 2015 

2 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Chairman and Chief Executive Officer’s Joint Review 
For the year ended 31 December 2015 

4D pharma plc (“4D”, the “Company” and, together with its subsidiaries, the “Group”) is a group based on nearly two 
decades of research into bacteria that could be considered to have a profound effect on disease pathways. During 2014 
the Group developed this research to build MicroRx; a discovery methodology that is able to rationally select those 
bacteria that have a precise and evolved therapeutic effect.  

Over the last twelve months, our MicroRx methodology has allowed 4D to expand its live biotherapeutics pipeline from two 
discovery projects to a pipeline of 15 therapeutic programmes covering autoimmune diseases, CNS disorders and cancer. 
Utilising MicroRx, 4D is able to rapidly develop its programmes into the clinic, currently having two programmes in patient 
trials, with the expectation to initiate another three programmes over the coming twelve months.  

In line with industry standard policies for research and development the Group will continue to expense the costs for this 
work until regulatory approval is achieved for candidates; only once this milestone is reached will the costs be capitalised.  

Bacteria, drugs and the regulators 
It is widely understood that bacteria within our gut, referred to as the microbiome, play a key role in the development and 
regulation of our immune systems. Building on this fact, it has been shown that bacteria not only play a crucial role in the 
regulation of diseases of the gut such as Crohn’s and irritable bowel syndrome, but also potentially those immune 
diseases that affect other parts of the body, such as rheumatoid arthritis, asthma and multiple sclerosis.  

Research into the microbiome and live biotherapeutics is an exciting area of development. There is intense interest as we 
begin to unravel the impact that the genes in our microbiome may have on our genes and also how the microbiome can 
impact the response to therapeutic regimes. The thinking within this area of research has moved swiftly from the role of 
bacteria in diseases of the gut to leading us towards trying to understand the link between the microbiome and diseases 
such as cancer and autism. 

Live biotherapeutics are drugs that build on the understanding of the microbiome and how bacteria can affect disease 
pathways. They are a class of drugs, regulated and defined by the FDA as “a biological product that contains live 
organisms, such as bacteria, applicable to the prevention, treatment or cure of a disease and are not vaccines”. The 
rationale for the regulators establishing this new class is based on the compelling scientific evidence provided by several 
leading academic groups, but also the advances made by companies, such as 4D, in bringing this new class of 
therapeutics to patients.  

At 4D we develop bacteria that are isolated from healthy humans. We believe these bacteria are safe and have no toxic 
effects. The lack of toxicity or side effects brings a significant advantage over existing therapies for diseases such as 
rheumatoid arthritis, Crohn’s or multiple sclerosis that are aggressive and can cause serious life-threatening conditions as 
a result of treatment.  

In allowing 4D to take its proprietary candidates into clinical trials in patients directly, the FDA and EMA concur with our 
views regarding the lack of toxicity and reduced side effects of the live biotherapeutics developed by 4D. 4D continues to 
work with the regulatory bodies to help determine the regulatory agenda and develop live biotherapeutics in the safest and 
most efficient route.  

From research to patients 
During 2014 the challenge for 4D was: could we rationally identify bacteria that were therapeutically relevant? With the aid 
of the MicroRx methodology, 4D showed we could identify bacteria that had effect in pharmaceutical standard models of 
rheumatoid arthritis, multiple sclerosis and asthma. 

The challenge in 2015 was: could 4D take the research and move this towards the clinic? Towards the end of 2015, we 
commenced our first trial in patients with irritable bowel syndrome and gained approval to start a trial in paediatric Crohn’s 
disease.  

We believe we are the first company to address an immune disease using live biotherapeutics delivered by an 
oral capsule.  

In simple terms this means we have addressed the development, optimisation, manufacturing, stability, encapsulation, 
dosing and regulatory challenges over the last twelve months which, under normal circumstances, we believe would take 
the pharmaceutical industry up to six years. 4D is pioneering in its approach which aims to take a novel pure piece of 
research into patient trails within an 18-month timeframe. This has been a huge achievement requiring considerable effort 
across the organisation.   

It has also been a significant learning process. As we continue to focus and refine these processes, we believe 4D will be 
able to increase the efficiency in taking our research into the clinic. 

4D pharma plc Annual Report and Financial Statements 2015 

3 

 
 
 
 
 
 
 
 
 
  
Chairman and Chief Executive Officer’s Joint Review continued 
For the year ended 31 December 2015 

New areas of research and future developments 
4D chose to initially focus on immune conditions associated with the gut. It was a logical step to look at the bacteria in the 
gut and look for a local effect. This research gave 4D programmes in paediatric Crohn’s, paediatric colitis and irritable 
bowel syndrome. 

All the above are immune-related disorders. As we began to understand the potential of bacteria in the pathways 
associated with these diseases, we focussed on other immune pathways using the MicroRx methodology to rationally 
select bacteria that could have a therapeutic effect in diseases such as rheumatoid arthritis, asthma and multiple sclerosis. 

Our research, understanding and ambition have moved on further.  

In August we initiated a research programme in conjunction with University College Cork to look at the potential effect of 
bacteria on conditions such as autism, depression and anxiety. This research will bring together the world-leading 
research at UCC in the gut–brain axis with the power of the MicroRx methodology, identifying those bacteria that have a 
disease-modifying effect. 

In late November, two publications in Science discussed the interaction of the microbiome in cancer: a paper by Sivian 
discussed the potential of constituents of microbiome to promote antitumor activity; and a paper by Vetizou highlighted 
that the patient’s microbiome could play a significant role in the response to treatment by a checkpoint inhibitor.  

Also in November, 4D announced its first live therapeutic oncology candidate, being the first company to do so globally. 
Both these programmes further demonstrate that 4D continues to lead in the research and development of live 
biotherapeutics into new areas and MicroRx can rapidly and efficiently build a pipeline that now covers diseases in CNS, 
cancer and autoimmunity. 

On 9 February 2016, 4D purchased the entire issued share capital of Tucana Health Limited, a company based in Cork in 
Ireland. Tucana, a start-up company from University College Cork, was founded by Prof Fergus Shanahan and Prof Paul 
O'Toole to investigate the use of microbiome signatures to aid the diagnosis and treatment of diseases, including those 
targeted by 4D. Following the acquisition, 4D will continue to build on this research, investing in the platform and building 
further research capability based at the APC Microbiome Institute at UCC. Initially, the focus will be on work on the 
diagnosis and patient stratification for Irritable Bowel Syndrome.  Longer term the Company will focus on building a 
diagnostic platform across multiple disease areas mirroring the programmes developed by MicroRx, 4D's therapeutic 
methodology.  This work will be led by Prof Fergus Shanahan and Prof Paul O'Toole, the founders of Tucana.  

Over the coming twelve months our aim is to further build and solidify our position; we will continue to develop our 
research and understanding of the microbiome, and expand our clinical programmes to rapidly bring safe, efficacious 
therapies to patients. 

Financial results and finance review 
Results 
R&D expenses were £6.9 million for the year ended 31 December 2015 (period to 31 December 2014: £1.8 million), 
reflecting the increase in activity and headcount.  

Administrative expenses were £3.6 million for the year ended 31 December 2015 (period to 31 December 2014: 
£1.7 million). The loss after tax for the year ended 31 December 2015 was £7.7 million or 12.62 pence per share (period to 
31 December 2014: £2.4 million or 4.81 pence per share). 

Total staff costs for the year were £1.1 million (period to 31 December 2014: £0.5 million), primarily driven by research and 
development through further studies using the MicroRx methodology which has identified candidates and on moving 
recognised candidates into the development phases.  

Corporation tax reclaims on research and development equated to £2.3 million with £1.6 million relating to reclaims for the 
current year and £0.7 million for the prior year (period to 31 December 2014: £Nil). 

Cash flow and balance sheet 
The Group had net assets at 31 December 2015 of £92.7 million (period to 31 December 2014: £37.0 million) and cash, 
cash equivalents, short-term investments and deposits of £85.4 million (period to 31 December 2014: £31.8 million). 

During the year 4D raised £64.8 million (before expenses) from existing and new shareholders. Funds were raised from 
two placings, the first in January 2015 to raise £34.8 million and the second in December 2015 to raise £30.0 million.  

The cost of issuing new share capital for the additional placings which amounted to £976,000, has been charged against 
the share premium account. 

During the year, the Company purchased the remaining non-controlling interest equating to 16.5% of the capital in 4D 
Pharma Research Limited at a cost of £0.4 million. In the period to 31 December 2014 83.5% of the capital was purchased 
for £1.730 million.  

4D pharma plc Annual Report and Financial Statements 2015 

4 

 
 
 
 
 
 
 
 
 
Chairman and Chief Executive Officer’s Joint Review continued 
For the year ended 31 December 2015 

Financial results and finance review continued 
Treasury activities and policies 
The Group manages its cash deposits prudently and invests its funds across a number of financial institutions which have 
investment-grade credit ratings. The deposits range from instant access to twelve-month term deposits and are regularly 
reviewed by the Board. Cash forecasts are updated monthly to ensure that there is sufficient cash available for the 
Group’s foreseeable requirements.  

Foreign exchange management 
The Group does not take out forward contracts against uncertain or forecast expenditure, as the timings and extent of 
future cash flow requirement denominated in foreign currencies are difficult to predict. Future currency needs are 
continually monitored and purchased when the extent and timings are known. 

David Norwood   
Non-executive Chairman  
30 March 2016 

Duncan Peyton 
Chief Executive Officer 
30 March 2016 

4D pharma plc Annual Report and Financial Statements 2015 

5 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The Board 

David Norwood – Non-executive Chairman 
David has had a long career building a number of science, technology and investment companies. He is the founder of IP 
Group plc, one of the UK’s leading technology commercialisation businesses, and a shareholder in the Company. 
Previously, he was Chief Executive of stockbroker Beeson Gregory (acquired by Evolution Group plc) after it acquired 
IndexIT Partnership, a technology advisory boutique he had founded in 1999. He was a founding shareholder of Evolution 
Group plc (recently acquired by Investec), and also co-founder of Ora Capital plc. He has been a founder and director of 
many UK technology companies, including Oxford Nanopore Technologies Ltd, Proximagen Ltd, Synairgen plc, Ilika 
Technologies Ltd, Oxford Catalysts and Plectrum Petroleum (acquired by Cairn Energy plc). He has also acted as seed 
investor and/or advisor to Wolfson Microelectronics Ltd, Nanoco Technologies Ltd, Tissue Regenix Group plc and Arc 
International (now part of Synopsys). He is also non-executive Chairman of Oxford Pharmascience Group plc. 

Duncan Peyton – Chief Executive Officer 
Duncan has a proven track record in identifying, investing in and growing businesses within the pharmaceutical sector. He 
was the founder of Aquarius Equity, a specialist investor in businesses within the life science sector, which provided 
investors with access to innovative, high growth potential companies that delivered significant capital growth. Duncan 
started his career in a bioscience start-up business, which ultimately went on to list on the London Stock Exchange, 
subsequently qualified as a corporate finance lawyer with Addleshaw Goddard, then Addleshaw Booth & Co, and later 
joined 3i plc as an investment manager. Duncan founded Aquarius Equity in 2005, which made founding investments into 
Nanoco Technologies Ltd, Auralis Limited (subsequently sold to ViroPharma) and Tissue Regenix Group plc. 

Dr Alexander Stevenson – Chief Scientific Officer 
Alex began his career as a scientist, working in research and for an NYSE-quoted drug development company, before 
moving into early-stage pharmaceutical and healthcare investments. He has fulfilled board-level investment and 
operational management roles. He was a director and shareholder in Aquarius Equity from 2008, where he was 
responsible for identifying new investments and developing and implementing scientific strategies both pre- and post-
investment. Prior to joining Aquarius Equity, Alex worked for IP Group plc where he specialised in life science investments, 
identifying, developing and advising a number of companies in its portfolio, some of which went on to list on AIM. He 
joined IP Group following its acquisition of Techtran Group Ltd in 2005. 

Thomas Engelen – Non-executive director 
Thomas is also non-executive Chairman at Akcros Holdings Ltd and Penlan Healthcare. Thomas has been a founder 
and/or non-executive director of a number of UK life sciences companies, including Colonis Pharma Ltd, Warneford 
Partners Ltd and Martindale Pharma Ltd. Thomas has supported private equity and other investors in over 50 potential 
deal transactions, on targets in Europe and the USA, from cash constrained/chapter 11 to cash-rich with EV of up to $1B. 
Before this, he worked in life sciences for over 20 years in senior executive roles. Starting in 1987 at Akzo Nobel Pharma 
he worked with hospital products, diagnostics and medical equipment as General Manager for the Middle East and Africa. 
After this, he led Rosemont Pharmaceuticals in Leeds in niche oral liquid medicines, followed by being President of 
Organon in Brazil. He was promoted to VP The Americas and, lastly, to CMO at Organon, in charge of the global product 
portfolio, based in the USA. Returning to Europe, he led Novartis Consumer Health in the UK. 

4D pharma plc Annual Report and Financial Statements 2015 

6 

 
 
 
 
 
 
 
 
 
 
 
 
Strategic Report 
For the year ended 31 December 2015 

The information required by schedule 7 of the Large and Medium-sized Companies and Groups (Accounts and Reports) 
Regulations 2008 has been included in the separate Strategic Report in accordance with section 414C(11) of the 
Companies Act 2006 (Strategic Report and Directors' Report) Regulations 2013. 

Principal activity 
The principal activity of the Group during the year (and that of the previous 51-week period) was the research and 
development of pharmaceutical products in new live biotherapeutic areas. 

Business model 
A description of the Group’s activities and how it seeks to add value are included in the Chairman and Chief Executive 
Officer’s (“CEO’s”) Joint Review on pages 3 to 5. 

Review of the business and future developments 
A review of the Group’s performance during the year and its future prospects are included in the Chairman and CEO’s 
Joint Review on pages 3 to 5, which should be read in conjunction with this report. 

Staff numbers in the Group increased during the year from 13 to 24, with staff costs increasing from £0.5 million for the 
period to 31 December 2014 to £1.1 million for the year to 31 December 2015 as the Group focussed on accelerating the 
MicroRx methodology and the development of existing candidates.   

Presently, the focus is on bringing a candidate to market and in locating other suitable candidates and one of the key 
components to achieving this is ensuring that the Group is adequately funded to get there and the Directors recognise the 
required cash to achieve this. There were two share issues in the year which collectively raised net proceeds, after costs, 
of £63.8 million (share issues in the period to 31 December 2014: £38.4 million) leaving cash and cash equivalents at 31 
December 2015 at £1.8 million (31 December 2014: £28.8 million) and a balance of £83.7 million on short-term deposits at 
the year end (2014: £3.0 million). The current cash position should allow the necessary further development of existing 
candidates and research into new candidates from the MicroRx methodology for the foreseeable future. 

Key performance indicators 
The key indicators of performance for the business in its current stage of development are the completion of technical 
milestones in relation to the development of targeted products and the research pipeline. In addition, the management and 
control of cash balances is a priority for the Group and these are budgeted and monitored closely to ensure the Group 
maintains adequate liquid resources to meet financial commitments as they arise. 

At this stage in its development, quantitative key performance indicators are not an effective way of measuring the Group’s 
performance. However, a qualitative summary of performance in the period is provided in the Chairman and CEO’s 
Joint Review. 

Principal risks and uncertainties 
The principal risks to achieving full commercialisation and to becoming cash generative are outlined as follows:  

Technology and development risk 
There can be no guarantee that any of the products currently in development will be developed into commercially viable 
products, meet regulatory requirements, be manufactured in commercial quantities at an acceptable cost or marketed 
successfully and profitably. The Group employs experienced development personnel who have experience of successfully 
bringing such products to the market. 

Regulatory risk 
Regulatory approval timelines can be affected by a number of factors, such as trial recruitment rates, clinical results and 
changes to regulatory requirements which are outside the control of the Group. However, all of the Group’s products follow 
well established regulatory routes and the Group works with experienced regulatory personnel and consultants to navigate 
the process. 

4D pharma plc Annual Report and Financial Statements 2015 

7 

 
 
 
 
 
 
 
 
 
 
 
Strategic Report continued 
For the year ended 31 December 2015 

Principal risks and uncertainties continued 
Competition 
Although the directors believe that for certain of the Group’s products there is limited direct competition, there may be 
products and competitors of which they are currently unaware, which could have a detrimental effect on the Group’s 
trading performance in the future. The Group expects a balanced exposure to competition with some offerings facing little 
competition, but others facing more. 

Attraction and retention of key employees 
The Group depends on directors and certain key employees spread across the various subsidiaries. The ability to attract 
and retain key employees cannot be guaranteed. However, the Group endeavours to ensure succession planning where 
possible and ensures that remuneration and incentive packages are in line with industry standards. 

On behalf of the Board  

Duncan Peyton 
Chief Executive Officer 
30 March 2016 

4D pharma plc Annual Report and Financial Statements 2015 

8 

 
 
 
 
 
 
 
 
 
 
 
 
Directors’ Report  
For the year ended 31 December 2015 

The directors present their report and the audited financial statements for the Group and the Company for the year ended 
31 December 2015. 4D pharma plc (formerly Schosween 18 Limited) was incorporated on 10 January 2014 and details of 
the various investments in subsidiaries are contained in note 12 to the financial statements. 

Directors 
The directors who held office during the year and as at the date of signing the financial statements were as follows: 

David Norwood 

Duncan Peyton 

Dr Alexander Stevenson 

Thomas Engelen   

Details of the directors’ remuneration are shown in the Report of the Remuneration Committee on page 15. Details of the 
directors’ interests in the share capital of the Company are set out below. 

No director had an interest in any contract that was significant in relation to the Company’s business at any time during 
the year. 

Financial instruments 
Details of the Group’s financial risk management objectives and policies are disclosed in note 23 to the 
financial statements. 

Research and development 
The principal activity of the Group is research and development, a review of which is included in the Chairman and CEO’s 
Joint Review on pages 3 to 5. 

Total research and development spend in the year to 31 December 2015 was £6.895 million (period to 31 December 
2014: £1.823 million). No development expenditure was capitalised in the current year or the previous 51-week period to 
31 December 2014. 

Corporation tax 
Corporation tax reclaims on research and development equated to £2.328 million with £1.641 million relating to reclaims 
for the current year and £0.687 million for the prior year (period to 31 December 2014: £Nil). 

Dividends 
The directors do not recommend payment of a dividend nor was there a dividend in the previous 51-week period to 31 
December 2014.  

Share capital and funding 
As at 31 December 2015 share capital comprised 64,365,198 ordinary shares of 0.25 pence each. There is only one class 
of share and all shares are fully paid. Full details of the Group’s and the Company’s share capital movements during the 
year are given in note 19 to the financial statements. 

Details of shares under option are provided in note 20 to the financial statements.   

Directors’ indemnity insurance 
The Group has maintained insurance throughout the year for its directors and officers against the consequences of actions 
brought against them in relation to their duties for the Group. Such provision remains in force as at the date of approval of 
the Directors’ Report. 

Directors’ interests 
Directors’ interests in the shares of the Company, including family and beneficial interests, at 31 December 2015 were: 

David Robert Norwood 
Duncan Joseph Peyton 
Dr Alexander James Stevenson 
Thomas Engelen 

Ordinary shares of 0.25 pence each 

31 December  
2015 
Number 
7,000,000 
6,250,286 
6,250,286 
500,000 

 31 December 
2015 
% 
10.9 
9.7 
9.7 
0.8 

31 December  
2014 
Number 
7,000,000 
6,250,286 
6,250,286 
500,000 

31 December  
2014 
% 
13.4 
12.0 
12.0 
1.0 

4D pharma plc Annual Report and Financial Statements 2015 

9 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Directors’ Report continued 
For the year ended 31 December 2015 

Substantial shareholders 
In addition to the Directors’ interests the Company is aware that the following had an interest in 3% or more of the issued 
ordinary share capital of the Company at 31 December 2015 based on the ordinary shares in issue of 64,365,198 (as at 
31 December 2014: 52,092,119): 

Woodford Investment Management LLP 
Invesco Asset Management Limited 
Lansdowne Partners 
Aviva Investors Global Services Limited 

Number of 0.25 pence 
ordinary shares  
as at 31 December 2015 
15,607,071 
9,163,617 
4,531,707 
2,926,132 

% of 
issued 
capital 
24.3 
14.2 
7.0 
4.6 

Number of 0.25 pence 
ordinary shares  
as at 31 December 2014 
6,857,113 
6,905,667 
3,800,000 
1,998,399 

% of 
issued 
capital 
13.2 
13.3 
7.3 
3.8 

There were no notified significant changes in these holdings between 31 December 2015 and the date of signing of these 
financial statements. 

Donations 
No charitable or political donations were made in the year or during the previous period. 

Acquisition of non-controlling interest 
During the year, the Company purchased the remaining non-controlling interest equating to 16.5% of the capital in 4D 
Pharma Research Limited at a cost of £0.402 million. In the period to 31 December 2014 83.5% of the capital was 
purchased for £1.730 million.  

Policy on payment of suppliers 
It is the policy and normal practice of the Group to make payments due to suppliers, in accordance with agreed terms and 
conditions, with payments being made generally in the month following receipt of invoice. 

Employment policies 
The Group is committed to ensuring the health and safety of its employees in the workplace. This includes the provision of 
regular medical checks. 

The Group supports the employment of disabled people where possible through recruitment, by retention of those who 
become disabled and generally through training, career development and promotion. 

The Group is committed to keeping employees as fully informed as possible with regard to the Group’s performance and 
prospects and seeks their views, wherever possible, on matters which affect them as employees. 

Corporate Governance Statement 
The Group’s statement on corporate governance can be found in the Corporate Governance Statement on pages 12 
to 14. 

Going concern 
The Chairman and CEO’s Joint Review on pages 3 to 5 outlines the business activities of the Group, along with the factors 
which may affect its future development and performance, and discusses the Group’s financial position, along with details 
of its cash flow and liquidity. Note 23 to the financial statements sets out the Group’s financial risks and the management 
of those risks. 

Having prepared management forecasts and made appropriate enquiries, the directors are satisfied that the Group has 
adequate cash and other resources for the foreseeable future, as the Group is at the start-up stage of its business 
lifecycle. Accordingly, they have continued to adopt the going concern basis in preparing the Group and Company 
financial statements. 

4D pharma plc Annual Report and Financial Statements 2015 

10 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Directors’ Report continued 
For the year ended 31 December 2015 

Disclosure of information to the auditor 
The directors who held office at the date of approval of this Directors’ Report confirm that: 

 

 

so far as they are each aware there is no relevant audit information of which the Group’s auditor is unaware; and 

each director has taken all the steps that he ought to have taken as a director to make himself aware of any 
relevant audit information and to establish that the Group’s auditor is aware of that information. 

Auditor 
RSM UK Audit LLP (formerly Baker Tilly UK Audit LLP) has indicated its willingness to continue in office.  

Ordinary resolutions to re-appoint RSM UK Audit LLP as auditor and to authorise the directors to agree its audit fee will be 
proposed at the forthcoming Annual General Meeting.  

Subsequent events 
On 10 February 2016, 4D pharma plc purchased the entire issued share capital of Tucana Health Limited. Further detail 
of this acquisition is contained in note 25.  

Annual General Meeting 
The Annual General Meeting of the Company will be held on 23 May 2016 at 2 p.m. at the Gridiron Building, 1 Pancras 
Square, London N1C 4AG. The notice convening the Annual General Meeting, together with an explanation of the 
resolutions to be proposed at the meeting, is contained in the notice of meeting on pages 43 to 48. 

Recommendation 
The Board considers that the resolutions to be proposed at the Annual General Meeting are in the best interests of the 
Company and it is unanimously recommended that shareholders support these proposals as the Board intends to do in 
respect of their own holdings. 

The Directors’ Report was approved by the Board on 30 March 2016 and was signed on its behalf by: 

Duncan Peyton 
Chief Executive Officer 
30 March 2016 

4D pharma plc Annual Report and Financial Statements 2015 

11 

 
 
 
 
 
 
 
 
 
 
 
 
Corporate Governance Statement  
For the year ended 31 December 2015 

Compliance 
The Board believes in the importance of corporate governance and is aware of its responsibility for overall corporate 
governance, and for supervising the general affairs and business of the Group. 

The Company’s shares are quoted on the AIM Market of the London Stock Exchange (“AIM”) and is subject to the 
continuing requirements of the AIM Rules. Although the Group is not required to comply with the UK Corporate 
Governance Code by virtue of being an AIM-quoted company, the Board seeks to apply the QCA Corporate Governance 
Code (as devised by the QCA in consultation with a number of significant institutional small company investors) to the 
extent appropriate and practical for a company of its nature and size. This section provides general information on the 
Group's adoption of the QCA Corporate Governance Code.  

Board composition and responsibility 
The Board consists of four directors, two of whom are non-executive. The names of the directors, together with their 
biographical details, are set out on page 6. 

The Board has determined that Thomas Engelen is independent in character and judgement and that there are no 
relationships or circumstances which could materially affect or interfere with the exercise of his independent judgement. 
The Board is satisfied with the balance between executive and non-executive directors, which allows it to exercise 
objectivity in decision making and proper control of the Group’s business. The Board considers its composition is 
appropriate in view of the size and requirements of the Group’s business and the need to maintain a practical balance 
between executives and non-executives. Due to the structure of the Company it is considered that it is not appropriate to 
change the successful Board composition at present. 

All directors appointed by the Board are subject to election by shareholders at the first Annual General Meeting after their 
appointment. Directors are also subject to retirement by rotation and re-election in accordance with the articles of 
association of the Company. 

The non-executive directors constructively challenge and help develop proposals on strategy and bring strong, 
independent judgement, knowledge and experience to the Board’s deliberations. The directors are given access to 
independent professional advice at the Group’s expense, when the directors deem it is necessary in order for them to 
carry out their responsibilities. 

The Board’s primary objective is to focus on adding value to the assets of the Group by identifying and assessing 
business opportunities and ensuring that potential risks are identified, monitored and controlled. Matters reserved for 
Board decisions include strategy, budget, performance, and approval of major capital expenditure and the framework 
of internal controls. The implementation of Board decisions and day-to-day operations of the Group are delegated to 
executive directors. 

The Board receives appropriate and timely information prior to each meeting, with a formal agenda and Board and 
Committee papers being distributed several days before meetings take place. Any director may challenge Group 
proposals, and decisions are taken democratically after discussion. Any director who feels that any concern remains 
unresolved after discussion may ask for that concern to be noted in the minutes of the meeting. Any specific actions 
arising from such meetings are agreed by the Board and then followed up by management. 

The Group maintains, for its directors and officers, liability insurance for any claims made against them in that capacity. 

The Group has effective procedures in place to deal with conflicts of interest. The Board is aware of other commitments 
of its directors and changes to these commitments are reported to the Board. 

The Board has established an Audit and Risk Committee and a Remuneration Committee, with formally delegated duties 
and responsibilities. The directors do not consider that, given the size of the Board, it is appropriate at this stage to have 
a nomination committee. However, this will be kept under regular review by the Board. 

Audit and Risk Committee 
The Audit and Risk Committee comprises Thomas Engelen as Chairman and David Norwood as the other member of the 
Committee. Thomas Engelen is an independent director and has recent and relevant financial experience. The Committee 
has primary responsibility for monitoring the quality of internal controls, ensuring that the financial performance of the 
Company is properly measured and reported on, and reviewing reports from the Company’s auditor relating to the 
Company’s accounting and internal controls, in all cases having due regard to the interests of shareholders. The Audit 
and Risk Committee will meet twice a year. 

4D pharma plc Annual Report and Financial Statements 2015 

12 

 
 
 
 
 
 
 
 
 
 
 
Corporate Governance Statement continued 
For the year ended 31 December 2015 

Remuneration Committee 
The Company has established a formal and transparent procedure for developing policy on Executive remuneration and 
for fixing the remuneration packages of individual directors. This Committee comprises Thomas Engelen as Chairman and 
David Norwood as the other member of the Committee. The Committee reviews the performance of the Executive 
directors and determines their terms and conditions of service, including their remuneration and the grant of options, 
having due regard to the interests of shareholders. The Remuneration Committee will meet at least once a year. 

The number of Board and Committee meetings attended by each of the directors during the year is shown below: 

Number of meetings in year 
Attendance: 
Executive directors 
Duncan Peyton 
Dr Alexander Stevenson 
Non-executive directors 
David Norwood 
Thomas Engelen 

Full Board 
12 

Audit and Risk Committee 
2 

Remuneration Committee 
1 

12 
10 

10 
8 

— 
— 

2 
2 

— 
— 

1 
1 

Approach to risk and internal control 
The Board is responsible for establishing and maintaining the Group’s systems of internal control. Internal control systems 
are designed to meet the particular needs of the Group and to address the risks to which it is exposed. By their nature, 
internal control systems are designed to manage rather than eliminate risk, and can provide only reasonable and not 
absolute assurance against material misstatement or loss. As stated, primary responsibility for monitoring the quality of 
internal control has been delegated to the Audit and Risk Committee. 

Communicating vision and strategy 
The directors seek to visit institutional shareholders at least twice a year. In addition, all shareholders are welcome to 
attend the Company’s Annual General Meeting, where there is an opportunity to question the directors as part of the 
agenda, or more informally after the meeting. Communication with shareholders is seen as an important part of the 
Board’s responsibilities, and care is taken to ensure that all price-sensitive information is made available to all 
shareholders at the same time. 

Share dealing 
The directors understand the importance of complying with the AIM Rules for Companies relating to directors’ dealings 
and has established a share dealing code which is appropriate for an AIM-quoted company. 

Annual General Meeting 
At the Annual General Meeting, separate resolutions will be proposed for each substantially different issue. The outcome 
of the voting on resolutions is disclosed by means of an announcement on AIM. 

Statement of directors’ responsibilities in relation to the Annual Report and financial statements 
The directors are responsible for preparing the Strategic Report, the Directors’ Report and the financial statements in 
accordance with applicable law and regulations. 

Company law requires the directors to prepare Group and Company financial statements for each financial year. The 
directors have elected to prepare the Group and Company financial statements in accordance with International Financial 
Reporting Standards ("IFRS") as adopted by the European Union (“EU”). 

The financial statements are required by law and IFRS adopted by the EU to present fairly the financial position and 
performance of the Group and the Company. The Companies Act 2006 provides, in relation to such financial statements, 
that references in the relevant part of that Act to financial statements giving a true and fair view are references to their 
achieving a fair presentation. 

4D pharma plc Annual Report and Financial Statements 2015 

13 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Corporate Governance Statement continued 
For the year ended 31 December 2015 

Statement of directors’ responsibilities in relation to the Annual Report and financial statements continued 
Under company law the directors must not approve the financial statements unless they are satisfied that they give a true 
and fair view of the state of affairs of the Group and the Company and of the profit or loss of the Group for that period.  

In preparing each of the Group and the Company financial statements, the directors are required to: 

a. 

b. 

c. 

d. 

select suitable accounting policies and then apply them consistently; 

make judgements and accounting estimates that are reasonable and prudent; 

for the Group financial statements, state whether they have been prepared in accordance with IFRS as adopted 
by the EU; and 

prepare the financial statements on the going concern basis unless it is inappropriate to presume that the Group 
and the Company will continue in business. 

The directors are responsible for keeping adequate accounting records that are sufficient to show and explain the Group’s 
and the Company’s transactions and disclose with reasonable accuracy at any time the financial position of the Group and 
the Company and enable them to ensure that the financial statements comply with the Companies Act 2006. They are 
also responsible for safeguarding the assets of the Group and the Company and hence for taking reasonable steps for the 
prevention and detection of fraud and other irregularities. 

The directors are responsible for the maintenance and integrity of the corporate and financial information included on the 
4D pharma plc website (www.4dpharmaplc.com). Legislation in the United Kingdom governing the preparation and 
dissemination of financial statements may differ from legislation in other jurisdictions. 

4D pharma plc Annual Report and Financial Statements 2015 

14 

 
 
 
 
 
 
 
 
 
 
 
Report of the Remuneration Committee 
For the year ended 31 December 2015 

Statement of compliance 
This report does not constitute a directors’ remuneration report in accordance with the Companies Act 2006. As a 
company whose shares are admitted to trading on AIM, the Company is not required by the Companies Act 2006 to 
prepare such a report. This report sets out the Group policy on directors’ remuneration, including emoluments, benefits 
and other share-based awards made to each director. 

Policy on Executive directors’ and senior management’s remuneration 
The overall policy of the Board is to ensure that Executive management is provided with appropriate incentives to 
encourage enhanced performance and is, in a fair and responsible manner, rewarded for its contribution to the success of 
the Group. 

The main elements of the remuneration packages for Executive directors and senior management are as follows: 

Basic annual salary 
The base salary is reviewed annually at the beginning of each year. The review process is undertaken by the 
Remuneration Committee and takes into account several factors, including the current position and development of the 
Group, individual contributions and market salaries for comparable organisations. 

The Company does not provide an occupational pension scheme for Executive directors, nor does it make contributions 
into the private pension schemes of Executives. 

Discretionary annual bonus 
All Executive directors and senior managers are eligible for a discretionary annual bonus. This takes into account 
individual contribution, business performance and technical and commercial progress, along with financial results. 

Discretionary share incentives 
The Group operates a share option scheme; all directors and employees are eligible for the granting of the options, which 
are at the discretion of Group when granted in accordance with the approved share option scheme requirements. Details 
of the grants made under the scheme are provided in note 20 to the financial statements. This takes into account the need 
to motivate and retain key individuals. Details of share options granted to directors are detailed in the directors’ 
remuneration note below. 

Benefits in kind 
The Company does not provide any taxable benefits for Executives. 

Policy on non-executive directors’ remuneration 
Non-executive directors receive a fixed fee and do not receive any pension payments or other benefits, nor do they 
participate in bonus or share schemes. The Remuneration Committee reviews non-executive remuneration to ensure that 
it is in line with current market rates in order to attract and retain high calibre individuals. 

Service contracts 
Duncan Peyton and Dr Alexander Stevenson have service agreements with an indefinite term providing for a maximum of 
twelve months’ notice by either party. 

Non-executive directors are employed on letters of appointment which may be terminated on not less than three 
months’ notice. 

Directors’ remuneration 
The remuneration of the directors who served on the Company’s Board during the year to 31 December 2015 
is as follows: 

31 December 2015 

Period to 31 December 2014 

Base salary and fees 
£000 

Total 
£000 

Base salary and fees 
£000 

Executive directors 
Duncan Peyton 
Dr Alexander Stevenson 
Non-executive directors 
David Norwood 
Thomas Engelen 

101  
101  

25  
33  
260  

101  
101  

25  
33  
260  

97 
97 

23 
47 
264 

Total 
£000 

97 
97 

23 
47 
264 

The directors were not granted any share options in the year ended 31 December 2015 or the period ended 31 December 
2014 and therefore none of the directors held any share options at 31 December 2015. There were no bonus or pension 
schemes for the directors during the year and for the period ended 31 December 2014. 

4D pharma plc Annual Report and Financial Statements 2015 

15 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Independent Auditor’s Report To the members of 4D pharma plc 
For the year ended 31 December 2015 

We have audited the group and parent company financial statements (“the financial statements”) on pages 17 to 42. 
The financial reporting framework that has been applied in their preparation is applicable law and International Financial 
Reporting Standards (“IFRSs”) as adopted by the European Union and, as regards the parent company financial 
statements, as applied in accordance with the provisions of the Companies Act 2006.  

This report is made solely to the company’s members, as a body, in accordance with Chapter 3 of Part 16 of the 
Companies Act 2006.  Our audit work has been undertaken so that we might state to the company’s members those 
matters we are required to state to them in an auditor’s report and for no other purpose.  To the fullest extent permitted 
by law, we do not accept or assume responsibility to anyone other than the company and the company’s members as a 
body, for our audit work, for this report, or for the opinions we have formed. 

Respective responsibilities of directors and auditor 
As more fully explained in the Directors’ Responsibilities Statement set out on pages 13 - 14, the directors are responsible 
for the preparation of the financial statements and for being satisfied that they give a true and fair view. Our responsibility 
is to audit and express an opinion on the financial statements in accordance with applicable law and International 
Standards on Auditing (UK and Ireland). Those standards require us to comply with the Auditing Practices Board’s (APB’s) 
Ethical Standards for Auditors. 

Scope of the audit of the financial statements 
A description of the scope of an audit of financial statements is provided on the Financial Reporting Council’s website 
at http://www.frc.org.uk/auditscopeukprivate. 

Opinion on financial statements 
In our opinion  

 

 

 

the financial statements give a true and fair view of the state of the group’s and the parent’s affairs as at 
31 December 2015 and of the group’s loss for the year then ended; 

the group financial statements have been properly prepared in accordance with IFRSs as adopted by the 
European Union; 

the parent financial statements have been properly prepared in accordance with IFRSs as adopted by the 
European Union and as applied in accordance with the Companies Act 2006; and 

 

the financial statements have been prepared in accordance with the requirements of the Companies Act 2006. 

Opinion on other matter prescribed by the Companies Act 2006 
In our opinion the information given in the Strategic Report and the Directors’ Report for the financial year for which the 
financial statements are prepared is consistent with the financial statements. 

Matters on which we are required to report by exception 
We have nothing to report in respect of the following matters where the Companies Act 2006 requires us to report to you 
if, in our opinion: 

 

 

 

adequate accounting records have not been kept by the parent company, or returns adequate for our audit have 
not been received from branches not visited by us; or 

the parent company financial statements are not in agreement with the accounting records and returns; or 

certain disclosures of directors’ remuneration specified by law are not made; or 

  we have not received all the information and explanations we require for our audit. 

Graham Bond FCA (Senior Statutory Auditor) 
For and on behalf of RSM UK AUDIT LLP (formerly Baker Tilly UK Audit LLP), 
Statutory Auditor  
Chartered Accountants 
3 Hardman Street 
Manchester 
M3 3HF 

4D pharma plc Annual Report and Financial Statements 2015 

16 

 
 
 
 
 
 
 
 
 
 
 
 
Group Statement of Total Comprehensive Income 
For the year to 31 December 2015 

Research and development costs 
Administrative expenses 
Operating loss 
Finance income 
Finance expense 
Share of losses in associated undertaking 
Gain on remeasurement of equity interest to fair value on acquisition 
of subsidiary 
Loss before taxation 
Taxation 
Loss for the year and total comprehensive income for the year 
Loss for the year and total comprehensive income for the year 
attributable to: 
Owners of the parent undertaking 
Non-controlling interests 
Loss for the year and total comprehensive income for the year 
Loss per share 
Basic and diluted for the year 

Notes 
4 
4 
4 
6 
6 
7 
7 

8 

31 December 
2015 
 £000 
(6,895) 
(3,615) 
(10,510) 
451 
— 
— 
— 

(10,059) 
2,328 
(7,731) 

(7,547) 
(184) 
(7,731) 

Period to  
31 December 
2014 
 £000 
(1,823) 
(1,653) 
(3,476) 
92 
(5) 
(379) 
1,388 

(2,380) 
— 
(2,380) 

(2,021) 
(359) 
(2,380) 

9 

(12.62)p 

(4.81)p 

The loss for the year arises from the Group’s continuing operations and is attributable to the equity holders of the parent. 

There were no other items of comprehensive income for the year and therefore the loss for the year is also the total 
comprehensive loss for the year. 

The basic and diluted loss per share are the same as the effect of share options is anti-dilutive. 

The notes on pages 24 to 42 form an integral part of these financial statements 

4D pharma plc Annual Report and Financial Statements 2015 

17 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Group Statement of Financial Position  
At 31 December 2015 

Assets 
Non-current assets 
Property, plant and equipment 
Intangible assets 

Current assets 
Inventories 
Trade and other receivables 
Taxation receivables 
Short-term investments and cash on deposit 
Cash and cash equivalents 

Total assets 
Liabilities 
Current liabilities 
Trade and other payables 

Non-current liabilities 
Deferred tax 

Total liabilities 
Net assets 
Capital and reserves 
Share capital 
Share premium account 
Merger reserve 
Other reserve 
Share-based payments reserve 
Retained earnings 
Attributable to owners of parent 
Non-controlling interest 
Total equity 

As at  
31 December  
2015 
£000 

As at  
31 December 
 2014  
£000 

Notes 

10 
11 

13 
14 
15 
16 
16 

17 

18 

19 
19 

20 

1,115 
6,171 
7,286 

28 
2,013 
2,623 
83,664 
1,777 
90,105 
97,391 

4,309 
4,309 

385 
385 
4,694 
92,697 

161 
102,003 
958 
(864) 
7 
(9,568) 
92,697 
— 
92,697 

417 
6,266 
6,683 

115 
356 
234 
3,007 
28,823 
32,535 
39,218 

1,785 
1,785 

385 
385 
2,170 
37,048 

130 
38,259 
958 
— 
— 
(2,021) 
37,326 
(278) 
37,048 

Approved by the Board and authorised for issue on 30 March 2016. 

The notes on pages 24 to 42 form an integral part of these financial statements. 

Duncan Peyton   
Director  
30 March 2016 

4D pharma plc Annual Report and Financial Statements 2015 

18 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Company Statement of Financial Position  
At 31 December 2015 

Assets 
Non-current assets 
Property, plant and equipment 
Intangible assets 
Investment in subsidiaries 

Current assets 
Loans to subsidiaries 
Trade and other receivables 
Taxation receivables 
Short-term investments and cash on deposit 
Cash and cash equivalents 

Total assets 
Liabilities 
Current liabilities 
Trade and other payables 
Total liabilities 
Net assets 
Capital and reserves 
Share capital 
Share premium account 
Merger reserve 
Share-based payments reserve 
Retained earnings 
Total equity 

As at 
31 December 
2015 
£000 

As at 
31 December 
2014  
£000 

Notes 

10 
11 
12 

12 
14 
15 
16 
16 

17 

19 
19 

20 

369 
1,076 
2,323 
3,768 

8,916 
1,940 
536 
83,664 
1,684 
96,740 
100,508 

2,768 
2,768 
97,740 

161 
102,003 
958 
7 
(5,389) 
97,740 

4 
— 
6,519 
6,523 

— 
194 
91 
3,007 
28,784 
32,076 
38,599 

417 
417 
38,182 

130 
38,259 
958 
— 
(1,165) 
38,182 

Approved by the Board and authorised for issue on 30 March 2016. 

The notes on pages 24 to 42 form an integral part of these financial statements. 

Duncan Peyton   
Director  
30 March 2016 

4D pharma plc Annual Report and Financial Statements 2015 

19 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Group Statement of Changes in Equity 
For the year to 31 December 2015 

Attributable to owners of parent 

Share 
capital 
£000 
— 

Share 
premium 
£000 
— 

Share-
based 
payment 
reserve 
£000 
— 

Merger 
reserve 
£000 
— 

Other 
reserve 
£000 
— 

Retained 
earnings 
£000 
— 

Non-
controlling 
interest 
£000 
— 

Total 
£000 
— 

Total 
equity 
£000 
— 

130 

38,259 

— 

958 

— 

—  39,347 

— 

39,347 

130 

38,259 

— 

958 

— 

—  39,347 

— 

39,347 

— 

— 

— 

— 

— 

(2,021) 

(2,021) 

(359) 

(2,380) 

— 
130 

— 
38,259 

31 

— 

63,744 

— 

31 

63,744 

— 

— 

— 
161 

— 
102,003 

— 
— 

— 

— 

— 

— 

7 
7 

— 
958 

— 

— 

— 
— 

— 

— 

— 
(2,021)  37,326 

81 
(278) 

81 
37,048 

—  63,775 

— 

63,775 

(864) 

— 

(864) 

462 

(402) 

— 

(864) 

—  62,911 

462 

63,373 

— 

— 
958 

— 

(7,547) 

(7,547) 

(184) 

(7,731) 

— 
(864) 

— 

7 
(9,568)  92,697 

— 
— 

7 
92,697 

At 10 January 2014 
Issue of share capital 
(net of expenses) 
Total transactions 
with owners 
recognised in equity 
for the period 
Loss and total 
comprehensive income 
for the period 
Non-controlling interest 
share of the net assets 
of the Group on 
acquisition 
At 31 December 2014 
Issue of share capital 
(net of expenses) 
Acquisition of minority 
interest 
Total transactions 
with owners 
recognised in equity 
for the year 
Loss and total 
comprehensive income 
for the year 
Issue of share-based 
compensation 
At 31 December 2015 

Details regarding the purpose of each reserve within equity are given in note 21. 

4D pharma plc Annual Report and Financial Statements 2015 

20 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Company Statement of Changes in Equity 
For the year to 31 December 2015 

At 10 January 2014 
Issue of share capital (net of expenses) 
Total transactions with owners 
recognised in equity for the period 
Loss and total comprehensive income 
for the period 
At 31 December 2014 
Issue of share capital (net of expenses) 
Total transactions with owners 
recognised in equity for the year 
Loss and total comprehensive income 
for the year 
Issue of share-based compensation 
At 31 December 2015 

Share capital 
£000 
— 
130 

Share 
premium 
£000 
— 
38,259 

Share-based 
payment 
reserve 
£000 
— 
— 

Merger 
reserve 
£000 
— 
958 

Retained 
earnings 
£000 
— 
— 

Total 
£000 
— 
39,347 

130 

38,259 

— 
130 
31 

— 
38,259 
63,744 

31 

63,744 

— 
— 
161 

— 
— 
102,003 

— 

— 
— 
— 

— 

— 
7 
7 

958 

— 
958 
— 

— 

— 
— 
958 

— 

39,347 

(1,165) 
(1,165) 
— 

(1,165) 
38,182 
63,775 

— 

63,775 

(4,224) 
— 
(5,389) 

(4,224) 
7 
97,740 

Details regarding the purpose of each reserve within equity are given in note 21. 

4D pharma plc Annual Report and Financial Statements 2015 

21 

 
 
 
 
 
 
 
 
 
 
 
 
Group Cash Flow Statement  
For the year to 31 December 2015 

Loss after taxation 
Adjustments for: 
Depreciation of property, plant and equipment 
Amortisation of intangible assets 
Finance income 
Loss on disposal of property, plant and equipment 
Finance expense 
Share-based compensation 
Gain on remeasurement of existing interest on 
acquisition of subsidiary to fair value 
Share of losses in associated undertaking 
Cash flows from operations before movements 
in working capital 
Changes in working capital: 
Decrease/(increase) in inventories 
Increase in trade and other receivables 
Increase in taxation receivables 
Increase in trade and other payables 
Cash outflow from operating activities 
Cash flows from investing activities 
Purchases of property, plant and equipment 
Purchase of software and other intangibles 
Loan advanced 
Acquisition of subsidiaries net of cash acquired 
Acquisition of non-controlling interest 
Interest received 
Monies placed on deposit 
Net cash outflow from investing activities 
Cash flows from financing activities 
Proceeds from issues of ordinary share capital 
Expenses on issue of shares 
Repayment of loan 
Interest paid 
Net cash inflow from financing activities 
(Decrease)/increase in cash and cash equivalents 
Cash and cash equivalents at the start of the year 
Cash and cash equivalents at the end of the year 

Year to 
31 December 2015 
£000 
(7,731) 

Period to 
31 December 2014 
£000 
(2,380) 

143 
110 
(451) 
2 
— 
7 

— 
— 

(7,920) 

87 
(1,375) 
(2,389) 
2,524 
(9,073) 

(845) 
(14) 
— 
— 
(402) 
170 
(80,657) 
(81,748) 

64,751 
(976) 
— 
— 
63,775 
(27,046) 
28,823 
1,777 

65 
49 
(92) 
— 
5 
— 

(1,388) 
379 

(3,362) 

(115) 
(240) 
(234) 
133 
(3,818) 

(264) 
— 
(1,076) 
238 
— 
92 
(3,007) 
(4,017) 

38,100 
(937) 
(500) 
(5) 
36,658 
28,823 
— 
28,823 

Notes 

10 
11 

7 
7 

10 
11 

19 

6 

16 

4D pharma plc Annual Report and Financial Statements 2015 

22 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Company Cash Flow Statement  
For the year to 31 December 2015 

Loss after taxation 
Adjustments for: 
Depreciation of property, plant and equipment 
Share-based consideration 
Impairment of investment 
Finance income 
Finance expense 
Cash flows from operations before movements in working capital 
Changes in working capital: 
Increase in trade and other receivables 
Increase in taxation receivables 
Increase in trade and other payables 
Cash outflow from operating activities 
Cash flows from investing activities 
Purchases of property, plant and equipment 
Acquisition of subsidiaries net of cash acquired 
Investment in share capital in subsidiary 
Acquisition of non-controlling interest 
Purchase of intangible fixed assets 
Loans to subsidiary undertakings 
Interest received 
Monies placed on deposit 
Net cash outflow from investing activities 
Cash flows from financing activities 
Proceeds from issues of ordinary share capital 
Expenses on issue of shares 
Repayment of loan 
Interest paid 
Net cash inflow from financing activities 
(Decrease)/increase in cash and cash equivalents 
Cash and cash equivalents at the start of the year 
Cash and cash equivalents at the end of the year 

Year to  
31 December 2015 
£000 
(4,224) 

Period to  
31 December 2014  
£000 
(1,165) 

10 
7 
986 
(451) 
— 
(3,672) 

(1,466) 
(445) 
2,352 
(3,231) 

(375) 
— 
(191) 
(402) 
(1,076) 
(6,189) 
170 
(80,657) 
(88,720) 

64,751 
(976) 
1,076 
— 
64,851 
(27,100) 
28,784 
1,684 

— 
— 
— 
(92) 
5 
(1,252) 

(194) 
(91) 
417 
(1,120) 

(4) 
(32) 
— 
— 
— 
(3,803) 
92 
(3,007) 
(6,754) 

38,100 
(937) 
(500) 
(5) 
36,658 
28,784 
— 
28,784 

Notes 

10 

12 

10 

12 
12 
11 
12 

19 
19 
11 
6 

16 

4D pharma plc Annual Report and Financial Statements 2015 

23 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements  
For the year ended 31 December 2015 

1. General information 
4D pharma plc (the “Company”) is an AIM-quoted company incorporated and domiciled in the UK. The locations and 
principal activities of the subsidiaries are set out in note 12. The Company is incorporated in England and Wales. The 
registered office is Third Floor, 9 Bond Court, Leeds LS1 2JZ. These Group financial statements consolidate those of the 
Company and its subsidiaries (together referred to as the “Group” and individually as “Group entities”) for the year ended 
31 December 2015. 

The financial statements of 4D pharma plc and its subsidiaries (the “Group”) for the year ended 31 December 2015 were 
authorised for issue by the Board of Directors on 30 March 2016 and the Statement of Financial Position was signed on 
the Board’s behalf by Duncan Peyton. 

The Company has elected to take the exemption under section 408 of the Companies Act 2006 not to present the parent 
company’s Statement of  Comprehensive Income. 

The significant accounting policies adopted by the Group are set out in note 3. 

2. Basis of preparation 
(a) Statement of compliance 
The Group’s financial statements have been prepared in accordance with International Financial Reporting Standards as 
adopted by the European Union (“IFRS”) and IFRS Interpretations Committee (“IFRSIC”) interpretations as they apply to 
the financial statements of the Group for the year ended 31 December 2015 and the requirements of the Companies Act 
2006 applicable to companies reporting under IFRS. 

(b) Basis of measurement 
The parent company and Group financial statements have been prepared on the historical cost basis except for the 
methods used to measure fair values of assets and liabilities, which are discussed in the respective notes and in note 3. 

(c) Going concern 
The Chairman and Chief Executive Officer’s Review on pages 3 to 5 outlines the business activities of the Group along 
with the factors which may affect its future development and performance. The Group’s financial position is discussed in 
the Financial Review on page 4 along with details of its cash flow and liquidity. Note 23 to the financial statements sets out 
the Group’s financial risks and the management of those risks. 

Having prepared management forecasts and made appropriate enquiries, the Directors are satisfied that the Group has 
adequate resources for the foreseeable future as the Group is at the start-up stage of its business lifecycle. Accordingly 
they have continued to adopt the going concern basis in preparing the Group and Company financial statements. 

(d) Functional and presentational currency 
These financial statements are presented in Pounds Sterling, which is the Group’s functional currency. All financial 
information presented has been rounded to the nearest thousand. 

(e) Use of estimates and judgements 
The preparation of financial statements requires management to make estimates and judgements that affect the amounts 
reported for assets and liabilities as at the reporting date and the amounts reported for revenues and expenses during the 
year. The nature of estimation means that actual amounts could differ from those estimates. Estimates and judgements 
used in the preparation of the financial statements are continually reviewed and revised as necessary. While every effort is 
made to ensure that such estimates and judgements are reasonable, by their nature they are uncertain and, as such, 
changes in estimates and judgements may have a material impact on the financial statements. 

The key sources of estimation uncertainty and critical accounting policies that have a significant risk of causing material 
adjustment to the carrying amount of assets and liabilities within the next financial year are discussed below. 

(i) Taxation 
Management judgement is required to determine the amount of tax assets that can be recognised, based upon the likely 
timing and level of future taxable profits together with an assessment of the effect of future tax planning strategies. The 
carrying value of the unrecognised tax losses at 31 December 2015 was £9.542 million. The value of the additional 
deferred tax asset not recognised at the year end is £1.908 million. Further information is included in note 8. 

(ii) Research and development 
Careful judgement by the directors is applied when deciding whether the recognition requirements for development costs 
have been met. This is necessary as the economic success of any product development is uncertain until such time as 
technical viability has been proven and commercial supply agreements are likely to be achieved. Judgements are based 
on the information available at each reporting date which includes the progress with testing and certification and progress 
on, for example, establishment of commercial arrangements with third parties. In addition, all internal activities related to 
research and development of new products are continuously monitored by the directors. Further information is included in 
note 3. 

4D pharma plc Annual Report and Financial Statements 2015 

24 

 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

2. Basis of preparation continued 
(e) Use of estimates and judgements continued 
(iii) Intangible fixed assets and goodwill 
Estimated impairment of intangible fixed assets and goodwill 
The Group tests annually whether intangible fixed assets and goodwill have suffered any impairment, in accordance with 
the accounting policy stated in note 3. The potential recoverable amounts of intangible fixed assets and goodwill have 
been determined based on value in use calculations. These calculations require the use of estimates both in arriving at the 
expected future cash flows and the application of a suitable discount rate in order to calculate the present value of these 
flows. There is a degree of judgement involved in making assessments of attributable values on acquisition and making 
impairment assessments. More detail is given in notes 3(h) and 3(i). 

Valuation of intangibles on acquisition 
Valuation of an early stage drug discovery pharmaceutical company is a notoriously difficult task. Analysis of financial 
history gives little indication of future performance. Despite this, for products currently in development, sales potentials can 
be estimated and management has used its own experience as well as consulting with external experts to establish best 
estimates of sales pricing and revenue forecasting and these can provide the starting point for valuing these products and 
ensuring that their value has not been impaired. In addition, clinical development risks, measured as product attrition 
failure rates, incurred as drugs progress through the clinic are reasonably well documented and can be applied as 
meaningful risk adjusters to account for the chance of development failure. 

3. Significant accounting policies 
The accounting policies set out below are applied consistently by Group entities. 

The Group financial statements are presented in Sterling and all values are rounded to the nearest thousand pounds 
except where otherwise indicated. 

(a) Basis of consolidation 
(i) Business combinations 
Business combinations are accounted for using the acquisition method as at the acquisition date – i.e. when control is 
transferred to the Group. Control is the power to govern the financial and operating policies of an entity so as to obtain 
benefits from its activities. In assessing control, the Group takes into consideration potential voting rights that are 
currently exercisable. The Group measures goodwill at the acquisition date as: 

 

 

 

the fair value of the consideration transferred; plus 

the recognised amount of any non-controlling interests in the acquiree; plus 

if the business combination is achieved in stages, the fair value of the pre-existing equity interest in the acquiree; 
less 

 

the net recognised amount (generally fair value) of the identifiable assets acquired and liabilities assumed. 

Transaction costs, other than those associated with the issue of debt or equity securities, that the Group incurs in connection 
with a business combination are expensed as incurred. 

(ii) Non-controlling interests 
For each business combination, the Group elects to measure any non-controlling interests in the acquiree either: 

  at fair value; or 

  at their proportionate share of the acquiree’s identifiable net assets, which are generally at fair value. 

Changes in the Group’s interest in a subsidiary that do not result in a loss of control are accounted for as transactions with 
owners in their capacity as owners. Adjustments to non-controlling interests are based on a proportionate amount of the 
net assets of the subsidiary. No adjustments are made to goodwill and no gain or loss is recognised in profit or loss. 

(iii) Subsidiaries 
Subsidiaries are entities controlled by the Group. The financial statements of subsidiaries are included in the consolidated 
financial statements from the date that control commences until the date that control ceases. 

4D pharma plc Annual Report and Financial Statements 2015 

25 

 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

3. Significant accounting policies continued 
(a) Basis of consolidation continued 
(iv) Investments in associates 
Associates are those entities in which the Group has significant influence, but not control or joint control, over the financial 
and operating policies. Significant influence is presumed to exist when the Group holds between 20% and 50% of the 
voting power of another entity. 

Investments in associates are accounted for under the equity method and are recognised initially at cost. The cost of the 
investment includes transaction costs. 

The consolidated financial statements include the Group’s share of the profit or loss and other comprehensive income of 
equity-accounted investees, after adjustments to align the accounting policies with those of the Group, from the date that 
significant influence or joint control commences until the date that significant influence or joint control ceases. 

When the Group’s share of losses exceeds its interest in an equity-accounted investee, the carrying amount of the 
investment, including any long-term interests that form part thereof, is reduced to zero, and the recognition of further 
losses is discontinued except to the extent that the Group has an obligation or has made payments on behalf of 
the investee. 

(v) Transactions eliminated on consolidation 
Intra-group balances and transactions, and any unrealised income and expenses arising from intra-group transactions, are 
eliminated in preparing the consolidated financial statements. Unrealised gains arising from transactions with equity-
accounted investees are eliminated against the investment to the extent of the Group’s interest in the investee. Unrealised 
losses are eliminated in the same way as unrealised gains, but only to the extent that there is no evidence of impairment. 

(b) Foreign currency transactions 
Transactions in foreign currencies are initially recorded in the functional currency by applying the spot rate ruling at the 
date of the transaction. Monetary assets and liabilities denominated in foreign currencies are retranslated at the functional 
currency rate of exchange ruling at the reporting date. All differences are recognised in profit or loss. 

Non-monetary items that are measured in terms of historical cost in a foreign currency are translated using the exchange 
rates as at the dates of the initial transactions. Non-monetary items measured at fair value in a foreign currency are 
translated using the exchange rates at the date when the fair value was determined. 

(c) Segmental reporting 
An operating segment is a component of an entity that engages in business activities from which it may earn revenues and 
incur expenses, whose operating results are regularly reviewed by the Group’s chief operating decision maker, being the 
Chief Executive Officer, to make decisions about resources to be allocated to the segment and assess its performance, 
and for which discrete financial information is available. As at the reporting date the Group operated as a single segment. 

(d) Lease payments 
Rentals payable under operating leases, which are leases where the lessor retains a significant proportion of the risks and 
rewards of the underlying asset, are charged in profit or loss on a straight-line basis over the expected lease term. 

Lease incentives received are recognised as an integral part of the total lease expense, over the term of the lease. 

(e) Finance income and finance expense 
Finance income comprises interest income on funds invested and changes in the fair value of financial assets at fair value 
through profit or loss. Interest income is recognised as interest accrues using the effective interest rate method. 

Finance expense comprises interest expense on borrowings, changes in the fair value of financial assets at fair value 
through the Group Statement of Comprehensive Income, impairment losses recognised on financial assets and losses 
on hedging instruments that are recognised in profit or loss. All borrowing costs are recognised using the effective 
interest method. 

(f) Income tax 
Income tax expense comprises current and deferred tax. Income tax expense is recognised in the Income Statement 
except to the extent that it relates to items recognised directly in equity or in other comprehensive income. 

Current income tax assets and liabilities for the current and prior years are measured at the amount expected to be 
recovered from, or paid to, the tax authorities. The tax rates and tax laws used to compute the amount are those that are 
enacted or substantively enacted by the reporting date. 

4D pharma plc Annual Report and Financial Statements 2015 

26 

 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

3. Significant accounting policies continued 
(f) Income tax continued 
Deferred income tax is recognised on all temporary differences arising between the tax bases of assets and liabilities and 
their carrying amounts in the financial statements with the following exceptions: 

  where the temporary difference arises from the initial recognition of goodwill or of an asset or liability in a 

transaction that is not a business combination and that at the time of the transaction affects neither accounting 
nor taxable profit or loss; and 

 

in respect of taxable temporary differences associated with investments in subsidiaries where the timing of the 
reversal of the temporary differences can be controlled and it is probable that the temporary differences will not 
reverse in the foreseeable future. 

Deferred income tax assets and liabilities are measured on an undiscounted basis using the tax rates and tax laws that 
have been enacted or substantially enacted by the date and which are expected to apply when the related deferred tax 
asset is realised or the deferred tax liability is settled. 

Deferred income tax assets are recognised to the extent that it is probable that future taxable profits will be available 
against which differences can be utilised. An asset is not recognised to the extent that the transfer or economic benefits in 
the future is uncertain. 

(g) Property, plant and equipment 
Property, plant and equipment are recognised initially at cost. After initial recognition, these assets are carried at cost less 
any accumulated depreciation and any accumulated impairment losses. Cost comprises the aggregate amount paid and 
the fair value of any other consideration given to acquire the asset and includes costs directly attributable to making the 
asset capable of operating as intended. 

Depreciation is computed by allocating the depreciable amount of an asset on a systematic basis over its useful life and is 
applied separately to each identifiable component. 

The following bases and rates are used to depreciate classes of assets: 

Office equipment, fixtures and fittings 

Plant and machinery 

Leasehold improvements   

– 

– 

– 

straight line over five years 

straight line over five years 

straight line over five years 

The carrying values of property, plant and equipment are reviewed for impairment if events or changes in circumstances 
indicate that the carrying value may not be recoverable, and are written down immediately to their recoverable amount. 
Useful lives and residual values are reviewed annually and where adjustments are required these are made prospectively. 

A property, plant and equipment item is de-recognised on disposal or when no future economic benefits are expected to 
arise from the continued use of the asset. Any gain or loss arising on the de-recognition of the asset is included in the 
Income Statement in the year of de-recognition. 

(h) Intangible assets 
Intellectual property and patents 
The carrying value of intangible fixed assets is reviewed annually for impairment whenever events or changes in 
circumstances indicate the carrying value may not be recoverable. 

At each reporting date the Group reviews the carrying value of its intangible assets to determine whether there is any 
indication that those assets have suffered an impairment loss. If any such indication exists the recoverable amount of the 
asset is estimated in order to determine the extent of the impairment loss. 

Where the asset does not generate cash flows that are independent from other assets, the Group estimates the 
recoverable amount of the cash-generating unit to which the asset belongs. A cash-generating unit is the smallest 
identifiable group of assets that generates cash inflows from other assets or group assets. 

Recoverable amount is the higher of fair value less costs to sell and value in use. In assessing value in use the estimated 
future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market 
assessments of the time value of money and the risks specific to the asset, for which the estimates of future cash flows 
have not been adjusted. 

4D pharma plc Annual Report and Financial Statements 2015 

27 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

3. Significant accounting policies continued 
(h) Intangible assets continued 
Intellectual property and patents continued 
If the recoverable amount of an asset is estimated to be less than its carrying amount, the carrying amount of the asset is 
reduced to its recoverable amount. An impairment loss is recognised as an expense immediately. 

Where an impairment loss subsequently reverses, the carrying amount of the assets is increased to the revised climate of 
its recoverable amount, but so that the increased carrying amount does not exceed the carrying amount that would have 
been determined had no impairment loss been recognised for the asset in prior years. A reversal of an impairment loss is 
recognised in profit or loss immediately. 

Amortisation is provided on the fair value of the asset and is calculated on a straight-line basis over its useful life. 
Amortisation is recognised within the Statement of Comprehensive Income. Intellectual property and patents acquired as 
part of a business combination are only amortised once technical viability has been proven and commercial agreements 
are likely to be achieved. 

Patents includes the costs associated with acquiring and registering patents in respect of intellectual property rights. 
Patents are amortised on a straight-line basis over their useful lives (ten years). 

Goodwill 
Goodwill on acquisitions, being the excess of the fair value of the cost of acquisition over the Group’s interest in the fair 
value of the identifiable assets and liabilities acquired, is capitalised and tested for impairment on an annual basis. 

Any impairment is recognised immediately in profit or loss and is not subsequently reversed. For the purpose of 
impairment testing goodwill is allocated to cash generating units of 4D pharma plc, which represent the smallest 
identifiable group of assets that generates cash inflows that are largely independent of the cash inflows from other assets 
or groups of assets. 

Software 
Software is recognised initially at cost. After initial recognition, these assets are carried at cost less any accumulated 
amortisation and any accumulated impairment losses. Cost comprises the aggregate amount paid and the fair value of 
any other consideration given to acquire the asset and includes costs directly attributable to making the asset capable of 
operating as intended. 

Amortisation is computed by allocating the amortisation amount of an asset on a systematic basis over its useful life and 
is applied separately to each identifiable component. Amortisation is applied to software over five years on a straight-
line basis. 

The carrying value of software is reviewed for impairment if events or changes in circumstances indicate that the carrying 
value may not be recoverable, and is written down immediately to their recoverable amount. Useful lives and residual 
values are reviewed annually and where adjustments are required these are made prospectively. 

A software item is de-recognised on disposal or when no future economic benefits are expected to arise from the 
continued use of the asset. Any gain or loss arising on the de-recognition of the asset is included in the Income Statement 
in the year of de-recognition. 

Internally generated intangible assets 
Expenditure on research activities is recognised in the Statement of Comprehensive Income as incurred. Expenditure 
arising from the Group’s development is recognised only if all of the following conditions are met: 

 

 

 

 

 

 

an asset is created that can be identified; 

it is probable that the asset created will generate future economic benefits; 

the development cost of the asset can be measured reliably; 

the Group has the intention to complete the asset and the ability and intention to use or sell it; 

the product or process is technically and commercially feasible; and 

sufficient resources are available to complete the development and to either sell or use the asset. 

Where these criteria have not been achieved, development expenditure is recognised in profit or loss in the year in which 
it is incurred. 

The Group has adopted the industry standard approach to the treatment of development expenditure by capitalising 
development costs at the point where regulatory approval is reached and the probability of generating future economic 
benefits is high.  

4D pharma plc Annual Report and Financial Statements 2015 

28 

 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

3. Significant accounting policies continued 
(i) Impairment of assets 
An asset’s recoverable amount is the higher of an asset’s or cash-generating unit’s fair value less costs to sell and its 
value in use and is determined for an individual asset, unless the asset does not generate cash inflows that are largely 
independent of those from other assets or groups of assets. Where the carrying value of an asset exceeds its recoverable 
amount, the asset is considered impaired and is written down to its recoverable amount. In assessing value in use, the 
estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market 
assessments of the time value of money and the risks specific to the asset. In determining fair value less costs of disposal, 
an appropriate valuation model is used; these calculations are corroborated by valuation multiples, or other available fair 
value indicators. Impairment losses on continuing operations are recognised in the Income Statement in those expense 
categories consistent with the function of the impaired asset. 

(j) Investments in subsidiaries 
Investments in and loans to subsidiaries are stated in the Company’s Statement of Financial Position at cost less provision 
for any impairment. 

(k) Inventories 
Inventories are stated at the lower of cost and net realisable value. Cost based on latest contractual prices includes 
all costs incurred in bringing each product to its present location and condition. Net realisable value is based on 
estimated selling price less any further costs expected to be incurred to disposal. Provision is made for slow-moving 
or obsolete items. 

(l) Cash, cash equivalents and short-term investments 
Cash and cash equivalents comprise cash at hand and deposits with maturities of three months or less. Short-term 
investments comprise deposits with maturities of more than three months, but no greater than twelve months. 

(m) Trade and other payables 
Trade and other payables are non-interest bearing and are initially recognised at fair value. They are subsequently 
measured at amortised cost using the effective interest rate method. 

(n) Financial assets and liabilities 
Financial assets and liabilities are recognised when the Group becomes party to the contracts that give rise to them and 
are classified as financial assets and liabilities at fair value through the Group Statement of Comprehensive Income. 
The Group determines the classification of its financial assets and liabilities at initial recognition and re-evaluates this 
designation at each financial year end. 

A financial asset or liability is generally de-recognised when the contract that gives rise to it is settled, sold or cancelled 
or expires. 

At the year end, the Group had no financial assets or liabilities designated at fair value through the Group Statement of 
Comprehensive Income. 

(o) Share-based payments  
Equity settled share-based payment transactions are measured with reference to the fair value at the date of grant, 
recognised on a straight line basis over the vesting period, based on the Company’s estimate of shares that will eventually 
vest. Fair value is measured using a suitable option pricing model.  

At each reporting date before vesting, the cumulative expense is calculated, representing the extent to which the vesting 
period has expired and management’s best estimate of the achievement or otherwise of non-market conditions and the 
number of equity instruments that will ultimately vest. The movement in cumulative expense since the previous reporting 
date is recognised in the Group Statement of Comprehensive Income, with a corresponding entry in equity.  

Where the terms of an equity-settled award are modified or a new award is designated as replacing a cancelled or settled 
award, the cost based on the original award terms continues to be recognised over the remainder of the original vesting 
period. In addition, an expense is recognised over the remainder of the new vesting period for the incremental fair value of 
any modification, based on the difference between the fair value of the original award and the fair value of the modified 
award, both as measured on the date of modification. No reduction is recognised if this difference is negative.  

Where awards are granted to the employees of the subsidiary company, the fair value of the awards at grant date is 
recorded in the Company’s financial statements as an increase in the value of the investment with a corresponding 
increase in equity via the share-based payment reserve.   

4D pharma plc Annual Report and Financial Statements 2015 

29 

 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

3. Significant accounting policies continued 
(p) Share capital 
Proceeds on issue of shares are included in shareholders’ equity, net of transaction costs. The carrying amount is not 
remeasured in subsequent years. 

(q) New accounting standards and interpretations  
Adoption of IFRS 
The Group and Company financial statements have been prepared in accordance with IFRS, IAS and IFRS Interpretations 
Committee (“IFRSIC”) effective as at 31 December 2015. The Group and Company have not chosen to adopt any 
amendments or revised standards early. 

IFRS issued but not yet effective 
At the date of issue of these financial statements, the following accounting standards and interpretations, which have not 
been applied, were in issue but not yet effective. The directors do not anticipate that adoption of these will have a material 
impact on the financial statements. 
Amendments to IFRS 11 

Accounting for Acquisitions of Interests in Joint Operations 

Amendments to IAS 16 and 38 

Clarification of Acceptable Methods of Depreciation and Amortisation 

Amendments to IAS 27 

Equity Method in Separate Financial Statements 

Amendments to IFRS 10 and IAS 28 

Various Standards 

Sale or Contribution of Assets between an Investor and its Associate 
or Joint Venture 
Annual Improvements to IFRSs 2012–2014 Cycle 

Amendments to IFRS 10, IFRS 12 and IAS 
28         
Amendments to IAS 1 

Investment Entities: Applying the Consolidation Exception 

Presentation of Financial Statements – Disclosure Initiative 

IFRS 15 

IFRS 9 

Revenue from Contracts with Customers 

Financial Instruments 

4. Operating loss 

By nature: 
Operating loss is stated after charging : 
Research and development expense 

Depreciation on property, plant, and equipment 
Amortisation of intangible assets 
Loss on disposal of property, plant and equipment 
Staff costs (see note 5) 
Foreign exchange (gains)/losses 
Operating lease rentals: 
  Land and buildings 
Auditor’s remuneration 
Legal and professional 
Consultancy 
Other costs 

Auditor’s remuneration: 
Audit services: 
- Fees payable to Company auditor for the audit of the parent and the consolidated 
accounts 
- Auditing the financial statements of subsidiaries pursuant to legislation 
- Non-audit services  
  Other services 
Total auditor’s remuneration 

31 December 
2015 
£000 

Period to  
31 December 
2014 
£000 

6,895 
6,895 
143 
110 
2 
1,083 
(82) 

121 
30 
1,106 
224 
878 
3,615 

14 

14 

2 
30 

1,823 
1,823 
65 
49 
— 
520 
3 

148 
30 
357 
202 
279 
1,653 

18 

12 

— 
30 

4D pharma plc Annual Report and Financial Statements 2015 

30 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

5. Staff costs 

Wages and salaries 
Social security costs 
Pension contributions 
Share-based compensation 

Year to  
31 December 
2015 
£000 
971 
97 
8 
7 
1,083 

Period to  
31 December 
2014 
£000 
470 
50 
— 
— 
520 

Directors’ remuneration (including benefits in kind) included in the aggregate remuneration 
above comprised: 
Emoluments for qualifying services 
264 
Directors’ emoluments (excluding social security costs, but including benefits in kind) disclosed above include £101,000 
(period to 31 December 2014: £97,000) paid to the highest paid director. 

260 

The directors were not granted any share options in the year ended 31 December 2015 or the period ended 31 December 
2014 and none of the directors held any share options at 31 December 2015.  

An analysis of the highest paid director’s remuneration is included in the Report of the Remuneration Committee. 

The average number of employees during the year (including directors) was as follows: 

Group 
Directors 
Laboratory and administrative staff 

6. Finance income and finance expense 

Finance income 
Bank interest receivable 
Finance expense 
Loan interest payable 

Year to  
31 December 
2015 
Number 
4 
20 
24 

Period to  
31 December 
2014 
Number 
4 
9 
13 

Year to  
31 December 
2015 
£000 

Period to  
31 December 
2014 
£000 

451 
— 
451 

92 
(5) 
87 

Bank interest receivable includes £280,818 (period to 31 December 2014: £12,000) which is receivable after the year end. 

7. Interest in associate 
In January 2014 the Group acquired a non-controlling interest in 4D Pharma Research Limited when it purchased 46% of 
the ordinary share capital. 4D Pharma Research Limited subsequently became a subsidiary of the Group.  
Year to 
31 December 
2015 
£000 
— 
— 
— 
— 
— 

Fair value of identifiable net assets on date associate became a subsidiary 
Gain on measurement of existing interest to fair value on acquisition of subsidiary 

Period to  
31 December 
2014 
£000 
(500) 
 379 
(121) 
1,509 
1,388 

Cash consideration of acquisition 
Share of losses in the associated undertaking 

4D pharma plc Annual Report and Financial Statements 2015 

31 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

8. Taxation 
The tax credit is made up as follows: 

Current income tax 
Total current income tax 
Adjustment in respect of prior years 
Current deferred tax 
Current year charge 
Total deferred tax 
Total income tax credit recognised in the year 

The income tax credit can be reconciled to the accounting loss as follows: 

Loss before taxation 
Tax at standard rate of 20% (period to 31 December 2014: 20%) 
Effects of: 
Expenses not deductible for tax purposes 
Enhanced research and development expenditure 
Gains not chargeable to tax 
Bank interest 
Property, plant, equipment and software timing differences 
Tax losses carried forward to future years 
Utilised losses from prior years  
Adjustment in respect of prior years 
Effects of variation on tax reclaims over the standard rate  
Tax income tax credit recognised in the year 

Year to 
31 December 
2015 
£000 

Period to  
31 December 
2014 
£000 

(1,398) 
(930) 

— 
— 
(2,328) 

— 

— 
— 
— 

Year to 
31 December  
2015 
£000 
(10,059) 
(2,012) 

Period to  
31 December 
2014 
£000 
(2,380) 
(476) 

7 
(1,276) 
— 
— 
(40) 
1,066 
234 
(930) 
623 
(2,328) 

100 
(18) 
(277) 
(55) 
(206) 
932 
— 
— 
— 
— 

At 31 December 2015, the Group had tax losses available for carry forward of approximately £9.542 million 
(period to 31 December 2014: £4.662 million). The Group has not recognised deferred tax assets relating to such 
earned forward losses of approximately £1.908 million (period to 31 December 2014: £0.932 million). 

At 31 December 2015, the Company had tax losses available for carry forward of approximately £3.740 million 
(period to 31 December 2014: £0.745 million). The Group has not recognised deferred tax assets relating to such 
earned forward losses of approximately £0.748 million (period to 31 December 2014: £0.149 million). 

Group’s management considers that there is insufficient evidence of future taxable income, taxable temporary differences 
and feasible tax-planning strategies to utilise all of the cumulative losses and therefore it is not considered certain that the 
deferred tax assets will be realised in full. If future income differs from current projections, this could significantly impact 
the tax charge or benefit in future years. 

9. Loss per share 

Loss for the year attributable to equity shareholders 
Weighted average number of shares: 
Ordinary shares in issue 
Basic loss per share (pence) 

Year to 
31 December  
2015 
£000 
(7,547) 

Period to  
31 December  
2014 
£000 
(2,021) 

59,823,755  42,001,850 
(4.81) 

(12.62) 

The basic and diluted loss per share are the same as the effect of share options is anti-dilutive. 

4D pharma plc Annual Report and Financial Statements 2015 

32 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

10. Property, plant and equipment 

Group 
Cost 
At 31 December 2014 
Additions 
Disposals 
Reclassification as intangible assets 
At 31 December 2015 
Depreciation 
At 31 December 2014 
Provided during the year 
Released on disposal 
At 31 December 2015 
Net book value: 
At 31 December 2015 
At 31 December 2014 

Company 
Cost 
At 31 December 2014 
Additions 
At 31 December 2015 
Depreciation 
At 31 December 2014 
Provided during the year 
At 31 December 2015 
Net book value: 
At 31 December 2015 
At 31 December 2014 

Fixtures, 
fittings and 
office 
equipment 
£000 

Plant and 
machinery 
£000 

Leasehold 
improvements 
£000 

6 
88 
— 
— 
94 

— 
6 
— 
6 

88 
6 

476 
653 
(4) 
(1) 
1,124 

65 
137 
(1) 
201 

923 
411 

— 
104 
— 
— 
104 

— 
— 
— 
— 

104 
— 

Fixtures, 
fittings and 
office 
equipment 
£000 

Plant and 
machinery 
£000 

Leasehold 
improvements 
£000 

4 
71 
75 

— 
3 
3 

72 
4 

— 
200 
200 

— 
7 
7 

193 
— 

— 
104 
104 

— 
— 
— 

104 
— 

Total 
£000 

482 
845 
(4) 
(1) 
1,322 

65 
143 
(1) 
207 

1,115 
417 

Total 
£000 

4 
375 
379 

— 
10 
10 

369 
4 

During the year, the directors reviewed the policy on the treatment of software and have concluded that software should 
be treated as intangible asset. They have therefore elected to transfer these assets from tangible assets to intangible 
assets. 

11. Intangible assets 

Group 
Cost 
At 31 December 2014 
Additions 
Reclassified from tangible assets 
At 31 December 2015 
Amortisation 
At 31 December 2014 
Provided during the year 
At 31 December 2015 
Net book value: 
At 31 December 2015 
At 31 December 2014 

Software 
£000 

Goodwill 
£000 

Intellectual 
property 
£000 

— 
14 
1 
15 

— 
2 
2 

13 
— 

3,316 
— 
— 
3,316 

— 
— 
— 

1,923 
— 
— 
1,923 

— 
— 
— 

3,316 
3,316 

1,923 
1,923 

Patents 
£000 

1,076 
— 
— 
1,076 

49 
108 
157 

919 
1,027 

Total 
£000 

6,315 
14 
1 
6,330 

49 
110 
159 

6,171 
6,266 

4D pharma plc Annual Report and Financial Statements 2015 

33 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

11. Intangible assets continued 

Company 
Cost 
At 31 December 2014 
Acquired 
At 31 December 2015 
Amortisation 
At 31 December 2014 
Provided during the year 
At 31 December 2015 
Net book value 
At 31 December 2015 
At 31 December 2014 

Patents 
£000 

— 
1,076 
1,076 

— 
— 
— 

Total 
£000 

— 
1,076 
1,076 

— 
— 
— 

1,076 
— 

1,076 
— 

Patent rights were acquired by 4D pharma plc from The Microbiota Company Limited (a 100% subsidiary) for £1.076 
million on 22 December 2015; the transaction was at arm’s length. 

Goodwill amounting to £3.316 million, intellectual property amounting to £1.923 million and patent rights amounting to 
£1.076 million relate to a cash-generating unit (“CGU”), being 4D Pharma Research Limited (formerly GT Biologics 
Limited) acquired on 10 June 2014 when the Group acquired 37.5% of the share capital for a total consideration of 
£1,730,255 and The Microbiota Company Limited acquired on 17 July 2014 when the Group acquired 100% of the share 
capital.  

Goodwill, which has arisen on the business combinations, represents staff and accumulated know-how after fair value has 
been attributed to all other assets and liabilities acquired. Intellectual property recognised on the business combinations 
represents bacteria identified by the Group’s know-how and processes and at different stages of research and 
development, from early identification to patented strains of bacteria. 

During the year goodwill, intellectual property, patents and associated property, plant and equipment was tested for 
impairment in accordance with IAS 36 Impairment of Assets. The recoverable amount of the CGU exceeds the carrying 
amount of goodwill, intellectual property, patents and associated property, plant and equipment. The recoverable amount 
of the CGU has been measured using a value-in-use calculation and, as such, no impairment was deemed necessary. 
The key assumptions used, which are based on management’s past experience, for the value-in-use calculations are 
those relating to the risk-adjusted net present value of candidates that have been identified as potential future products as 
at 31 December 2015 and for which estimated potential peak sales have been estimated. The value-in-use calculations 
are based on the future cash flows from approved risk-based net present value calculations that have been derived from 
biotechnology industry standard discount factor tables. Valuation of an early stage drug discovery pharmaceutical 
company is a notoriously difficult task. Analysis of financial history gives little indication of future performance. Despite this, 
for products currently in development, sales potentials can be estimated and management has used its own experience as 
well as consulting with external experts to establish best estimates of sales pricing and revenue forecasting and these can 
provide the starting point for valuing these products and ensuring that their value has not been impaired.  

The recoverable amount of goodwill, intellectual property, patents and associated property, plant and equipment exceeds 
the carrying amount by 947%. The directors consider the peak projected sales to be the most sensitive assumptions used 
in the impairment reviews. A reduction in excess of 91% in the estimated annual peak sales to be achieved would result in 
the recoverable amount of the CGU being equal to its carrying amount. 

Intangible assets, other than goodwill and intangible assets purchased as part of the acquisition of a subsidiary, are 
amortised on a straight-line basis over ten years. Amortisation provided during the year is recognised in administrative 
expenses. Patents amounting to £1.076 million were purchased by The Microbiota Company Limited in 2014 immediately 
prior to its acquisition by the Group on 17 July 2014 via a loan advanced by 4D pharma plc. 

4D pharma plc Annual Report and Financial Statements 2015 

34 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

12. Investment and loans to subsidiaries 

Non-current assets 
Company 
At 31 December 2014 
Additions in the year 
Transferred to current assets 
Impairment of investments 
At 31 December 2015 
By subsidiary 
4D Pharma Research Limited 
At 31 December 2015 

Ordinary 
Shares  
£000 

Loans to 
subsidiary 
undertakings  
£000 

2,716 
593 
— 
(986) 
2,323 

2,323 
2,323 

3,803 
— 
(3,803) 
— 
— 

— 
— 

Total  
£000 

6,519 
593 
(3,803) 
(986) 
2,323 

2,323 
2,323 

Effective from 22 December 2015 the patent rights held by The Microbiota Company Limited were sold to 4D pharma plc. 
The directors have reviewed the carrying value of the investment since the patents rights constituted substantially all the 
assets in The Microbiota Company Limited and these have been transferred to 4D pharma plc. The outcome of the review 
is that the directors have impaired the carrying value in full. 

Current assets 
Company 
At 31 December 2014 
Transferred from non-current assets 
Additions in the year 
Repaid during the year 
At 31 December 2015 
By subsidiary 
4D Pharma Research Limited 
At 31 December 2015 

Loans to 
subsidiary 
undertakings  
£000 

— 
3,803 
6,189 
(1,076) 
8,916 

8,916 
8,916 

During the year, the nature of the loans to subsidiary companies was reviewed. Following on from this review the Group 
has agreed that the nature of these means that they should be reclassified as current assets from non-current assets. The 
fair value of these loans is considered to be that of their current value. 

The following addition was settled in cash: 

Subsidiary 
4D Pharma Research Ltd 

 Principal activity 
Research and development 

Date of acquisition 
24 March 2015 

Proportion of voting 
equity interests 
acquired 
16.5% 

Consideration 
transferred 
£000 
402 

On 24 March 2015 the Group acquired the remaining non-controlling interest for £402,000. The total deficit on the fair 
value of the non-controlling interest at this point was £462,000. This transaction has resulted in the creation of the other 
reserve within equity which totals £864,000 and represents the difference between the consideration transferred and the 
total deficit on the fair value of the non-controlling interest at the date of acquisition.   

As detailed in note 24 the acquisition of the non-controlling interest has resulted in a payment from 4D pharma plc to 4D 
Pharma Research Limited for £191,160.    

4D pharma plc Annual Report and Financial Statements 2015 

35 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

12. Investment and loans to subsidiaries continued 
Subsidiary undertakings 
4D Pharma Research Limited  
The Microbiota Company Limited 
Schosween 18 Limited 

Country of incorporation 
Scotland 
England and Wales 
England and Wales 

Principal activity 
Research and development 
Research and development 
Dormant 

31 December 2015 
100% 
100% 
100% 

The shares in all the companies listed above are held by 4D pharma plc. 

The following wholly owned subsidiaries were dormant and have been wound up during the year: 
Subsidiary undertakings 
GT Prohealth Limited 
GT Therapeutics Limited 

Country of incorporation 
Scotland 
Scotland 

13. Inventories 

Consumables 

31 December 
2015 
Group 
£000 
28 

31 December 
2015 
Company 
£000 
— 

31 December 
2014 
Group 
£000 
115 

31 December 
2014 
Company 
£000 
— 

The directors consider that the carrying amount of inventories is the lower of cost and market value. 

During the year £87,000 (period to 31 December 2014: £Nil) of inventories were expensed to the Income Statement.  

14. Trade and other receivables 

Prepayments 

31 December 
2015 
Group 
£000 
2,013 

31 December 
2015 
Company 
£000 
1,940 

31 December 
2014 
Group 
£000 
356 

31 December 
2014 
Company 
£000 
194 

The directors consider that the carrying amount of trade and other receivables approximates to their fair value. 

15. Taxation receivables 

Corporation tax 
VAT 

31 December 
2015 
Group 
£000 
2,328 
295 
2,623 

31 December 
2015 
Company 
£000 
477 
59 
536 

31 December 
2014 
Group 
£000 
— 
234 
234 

31 December 
2014 
Company 
£000 
— 
91 
91 

The directors consider that the carrying amount of taxation receivables approximates to their fair value. 

16. Cash, cash equivalents and deposits 

Short-term investments and cash on deposit 
Cash and cash equivalents 

31 December 
2015 
Group 
£000 
83,664 
1,777 
85,441 

31 December 
2015 
Company 
£000 
83,664 
1,684 
85,348 

31 December 
2014 
Group 
£000 
3,007 
28,823 
31,830 

31 December 
2014 
Company 
£000 
3,007 
28,784 
31,791 

Under IAS 7 Statement of Cash Flows, cash held on long-term deposits (being deposits with maturity of greater than three 
months and no more than twelve months) that cannot readily be converted into cash has been classified as a short-term 
investment. The maturity on this investment was less than twelve months at the reporting date. 

Cash and cash equivalents at 31 December 2015 include deposits with original maturity of three months or less of 
£1,777,000 (Group) and £1,684,000 (Company). 

The directors consider that the carrying value of cash and cash equivalents approximates their fair value. For details on 
the Group’s credit risk management refer to note 23. 

4D pharma plc Annual Report and Financial Statements 2015 

36 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

17. Trade and other payables 

Current 
Trade payables 
Other payables 
Taxation and social security 
Accruals 

31 December 
2015 
Group 
 £000 
2,891 
23 
42 
1,353 
4,309 

31 December 
2015 
Company 
£000 
1,808 
20 
24 
916 
2,768 

31 December 
2014 
Group  
£000 
1,375 
32 
23 
355 
1,785 

31 December 
2014 
Company 
£000 
302 
29 
19 
67 
417 

Trade and other payables principally comprise amounts outstanding for trade purchases and ongoing costs. Trade 
payables are non-interest bearing and are typically settled on 30 to 45-day terms. 

The directors consider that the carrying value of trade payables, other payables and accruals approximates to their 
fair value. 

All trade and other payables are denominated in Sterling. 

The Group has financial risk management policies in place to ensure that any trade payables are settled within the credit 
time frame and no interest has been charged by any suppliers as a result of late payment of invoices during the reporting 
year presented herein. 

18. Deferred tax 

At 10 January 2014 
Arising on the fair value acquisition of intellectual property on the 
acquisition of subsidiaries 
At 31 December 2014 
Provided in the year 
At 31 December 2015 

31 December 
2015 
Group 
£000 
— 

31 December 
2015 
Company 
£000 
— 

385 
385 
— 
385 

— 
— 
— 
— 

Group’s management considers that there is insufficient evidence of future taxable income, taxable temporary differences 
and feasible tax-planning strategies to utilise all of the cumulative losses and therefore it is not considered certain that the 
deferred tax assets will be realised in full. If future income differs from current projections, this could significantly impact 
the tax charge or benefit in future years. No deferred tax asset has been recognised due to the uncertainty surrounding its 
recoverability. 

19. Share capital 

The Company and the Group 
Allotted, called up and fully paid ordinary shares of 0.25p 
Shares issued at par between 10 January and 18 January 2014 
Shares issued on 18 February 2014 
Expenses of placing on 18 February 2014 
Shares issued on the acquisition of a subsidiary on 3 June 2014 
Shares issued on 14 July 2014 
Expenses of placing on 14 July 2014 
Shares issued on the acquisition of a subsidiary on 17 July 2014 
As at 31 December 2014 
Shares issued on 10 February 2015 
Expenses of placing on 10 February 2015 
Shares issued on 11 December 2015 
Expenses of placing on 11 December 2015 
Ordinary shares as at 31 December 2015 

Ordinary shares 
Number 

20,000,000 
16,550,000 

699,500 
14,333,334 

509,285 
 52,092,119 
8,475,610 
— 
3,797,469 
— 
64,365,198 

Share 
capital 
£000 

Share 
premium 
£000 

50 
41 

2 
36 

1 
130 
21 
— 
10 
— 
161 

— 
16,509 
(503) 
1,222 
21,464 
(433) 
— 
38,259 
34,729 
(487) 
29,991 
(489) 
102,003 

Total 
£000 

50 
16,550 
(503) 
1,224 
21,500 
(433) 
1 
38,389 
34,750 
(487) 
30,001 
(489) 
102,164 

4D pharma plc Annual Report and Financial Statements 2015 

37 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

19. Share capital continued 
The balances classified as share capital and share premium include the total net proceeds (nominal value and share 
premium respectively) on issue of the Company’s equity share capital, comprising 0.25 pence ordinary shares. 

The Company issued in aggregate 20,000,000 ordinary shares of 0.25 pence at par value between 10 January 2014 and 
18 January 2014. 

The Company raised gross proceeds of £16,550,000 from a placing on 18 February 2014 through the issue of 16,550,000 
new ordinary shares at an issue price of 100 pence per share. Issue costs associated with the placing totalled £503,212. 

The Company raised gross proceeds of £21,500,000 from a placing on 14 July 2014 through the issue of 14,333,334 new 
ordinary shares at an issue price of 150 pence per share. Issue costs associated with the placing totalled £433,000. 

The Company raised gross proceeds of £34,750,000 from a placing on 10 February 2015 through the issue of 8,475,610 
new ordinary shares at an issue price of 410 pence per share. Issue costs associated with the placing totalled £487,000.  

The Company raised gross proceeds of £30,000,000 from a placing on 11 December 2015 through the issue of 3,797,469 
new ordinary shares at an issue price of 790 pence per share. Issue costs associated with the placing totalled £489,000. 

20. Share-based payment reserve 
Share-based payment reserve 
The Group and the Company 
At 31 December 2014 
Share-based compensation 
At 31 December 2015 

£000 
— 
7 
7 

The share-based payment reserve accumulates the corresponding credit entry in respect of share-based payment 
charges. Movements in the reserve are disclosed in the Group Statement of Changes in Equity. 

A charge of £7,000 has been recognised in the Statement of Comprehensive Income for the year 
(period to 31 December 2014: £Nil). 

Share option schemes 
The Group operates the following unapproved share option scheme: 

4D pharma plc 2015 Long Term Incentive Plan (“LTIP”) 

– Grant in November 2015 

Share options were granted to staff members on 10 November 2015. Share options are awarded to management and key 
staff as a mechanism for attracting and retaining key members of staff. These options vest over a three-year period from 
the date of grant and are exercisable until the tenth anniversary of the award. Exercise of the award is subject to the 
employee remaining a full-time member of staff at the point of exercise.  

The fair value benefit is measured using a Black Scholes model, taking into account the terms and conditions upon which 
the share options were issued.  

The Group and the Company 
Outstanding at the start of the year/period 
Granted during the year 
Outstanding at 31 December 
Exercisable at 31 December 

Weighted average exercise price of options 

The Group and the Company 
Outstanding at the start of the year/period 
Granted during the year 
Outstanding at 31 December  

2015 
Number 
— 
40,909 
40,909 
— 

2015 
Pence 
— 
0.25 
0.25 

2014 
Number 
— 
— 
— 
— 

2014 
Pence 
— 
— 
— 

For the share options outstanding as at 31 December 2015, the weighted average remaining contractual life is 9.9 years. 

No share options were exercised during the year (period to 31 December 2014: none) and no share options were 
exercisable at 31 December 2015 and 31 December 2014. 

4D pharma plc Annual Report and Financial Statements 2015 

38 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

20. Share-based payment reserve continued 
Share option schemes continued 
The following table lists the inputs to the models used for the year ended 31 December 2015: 

The Group and the Company 
Expected volatility  
Risk-free interest rate  
Expected life of options  
Weighted average exercise price  
Weighted average share price at date of grant  

2015 
52.5% 
0.87% 
3 years 
0.25p 
770p 

The expected life of the options is based on historical data and is not necessarily indicative of exercise patterns that may 
occur. The expected volatility reflects the assumption that the historical volatility is indicative of future trends, which may 
also not necessarily be the actual outcome. 

No dividends were assumed to be paid in the foreseeable future.  

The model assumes, within the calculation of the charge, delivery of options that are dependent on a judgemental 
comparison to the total shareholder return against a specified comparator group of companies upon passing of the 
vesting period.  

No other features of options granted were incorporated into the measurement of fair value. 

21. Capital and reserves  
The components of equity are as follows: 

Called-up share capital 
The share capital account includes the par value for all shares issued and outstanding. 

Share premium account 
The share premium account is used to record amounts received in excess of the nominal value of shares on issue of new 
shares less the costs of new share issues. 

Merger reserve 
The merger reserve comprises the premium arising on shares issued as consideration for the acquisition of subsidiary 
undertakings where merger relief under section 612 of the Companies Act 2006 applies. 

Retained earnings 
Retained earnings includes the accumulated profits and losses arising from the Group Statement of Comprehensive 
Income and certain items from other comprehensive income attributable to equity shareholders net of distributions 
to shareholders. 

Non-controlling interest 
This reserve includes the accumulated profits and losses arising from the Group Statement of Comprehensive Income 
and certain items from other comprehensive income attributable to the minority equity shareholders of subsidiary 
undertakings not wholly owned by the Group. 

Other reserve 
The other reserve represents the balance arising on the acquisition of the former non-controlling interest in 4D Pharma 
Research Limited.  

Share-based payment reserve 
The share-based payment reserve accumulates the corresponding credit entry in respect of share-based compensation 
charges. Movements in the reserve are disclosed in the Group Statement of Changes in Equity. 

4D pharma plc Annual Report and Financial Statements 2015 

39 

 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

22. Commitments 
Operating lease commitments 
The Group leases premises under non-cancellable operating lease agreements. The future aggregate minimum lease and 
service charge payments under non-cancellable operating leases are as follows: 

Land and buildings: 
  Not later than one year 
  After one year but not more than five years 

31 December 
2015 
Group 
£000 

31 December 
2015 
Company 
£000 

31 December 
2014 
Group 
£000 

31 December 
2014  
Company 
£000 

126 
236 
362 

43 
160 
203 

210 
402 
612 

— 
— 
— 

Capital expenditure 
The Group has no committed capital expenditure at 31 December 2015 nor at 31 December 2014. 

The Company has no committed capital expenditure at 31 December 2015 nor at 31 December 2014. 

Contractual commitments 
The Group has the following non-cancellable contractual commitments at the balance sheet date: 

Research and development: 
  Not later than one year 
  After one year but not more than five years 

31 December 
2015 
Group 
£000 

31 December 
2015 
Company 
£000 

31 December 
2014 
Group 
£000 

31 December 
2014  
Company 
£000 

1,011 
396 
1,407 

1,011 
396 
1,407 

— 
— 
— 

— 
— 
— 

23. Financial risk management  
Overview 
This note presents information about the Group’s exposure to various kinds of financial risks, the Group’s objectives, 
policies and processes for measuring and managing risk, and the Group’s management of capital. 

The Board of directors has overall responsibility for the establishment and oversight of the Group’s risk management 
framework. The Executive directors report regularly to the Board on Group risk management. 

Capital risk management 
The Company reviews its forecast capital requirements on a half-yearly basis to ensure that entities in the Group will be 
able to continue as a going concern while maximising the return to stakeholders. 

The capital structure of the Group consists of equity attributable to equity holders of the parent, comprising issued share 
capital, reserves and retained earnings as disclosed in note 19 and in the Group Statement of Changes in Equity. Total 
equity was £92.697 million at 31 December 2015 (period to 31 December 2014: £37.048 million). 

The Company is not subject to externally imposed capital requirements. 

Liquidity risk 
The Group’s approach to managing liquidity is to ensure that, as far as possible, it will always have sufficient liquidity to 
meet its liabilities when due, under both normal and stressed conditions, without incurring unacceptable losses or risking 
damage to the Group’s reputation. 

The Group manages all of its external bank relationships centrally in accordance with defined treasury policies. The 
policies include the minimum acceptable credit rating of relationship banks and financial transaction authority limits. Any 
material change to the Group’s principal banking facility requires Board approval. The Group seeks to mitigate the risk of 
bank failure by ensuring that it maintains relationships with a number of investment grade banks. 

4D pharma plc Annual Report and Financial Statements 2015 

40 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

23. Financial risk management continued 
Liquidity risk continued 
At the reporting date the Group was cash positive with no outstanding borrowings. 

Categorisation of financial instruments  
31 December 2015 
Group 
Cash and cash equivalents 
Trade and other payables 

Company 
Cash and cash equivalents 
Trade and other payables 

Categorisation of financial instruments  
31 December 2014 
Group 
Cash and cash equivalents 
Trade and other payables 

Company 
Cash and cash equivalents 
Trade and other payables 

Fixed 
rate 
£000 

62,211 
— 
62,211 

62,211 
— 
62,211 

Fixed 
rate 
£000 

4,009 
— 
4,009 

4,009 
— 
4,009 

Floating 
rate 
£000 

23,230 
— 
23,230 

23,137 
— 
23,137 

Non-interest 
bearing 
£000 

— 
(2,914) 
(2,914) 

— 
(1,828) 
(1,828) 

Floating 
rate 
£000 

Non-interest 
bearing 
£000 

27,821 
— 
27,821 

27,782 
— 
27,782 

— 
(1,767) 
(1,767) 

— 
(331) 
(331) 

Total 
£000 

85,441 
(2,914) 
82,527 

85,348 
(1,828) 
83,520 

Total 
£000 

31,830 
(1,767) 
30,063 

31,791 
(331) 
31,460 

The values disclosed in the above table are carrying values. The Board considers that the carrying amount of financial 
assets and liabilities approximates to their fair value. 

Interest rate risk 
As the Group has no significant borrowings the risk is limited to the reduction of interest received on cash surpluses held 
at bank which receive a floating rate of interest. The exposure to interest rate movements is immaterial. 

Maturity profile 
The directors consider that the carrying amount of the financial liabilities approximates to their fair value. 

As all financial assets are expected to mature within the next twelve months an aged analysis of financial assets has not 
been presented. 

As all financial liabilities are expected to mature within the next twelve months an aged analysis of financial liabilities has 
not been presented. 

Foreign currency risk 
The Group is exposed to currency risk on sales and purchases that are denominated in a currency other than the 
respective functional currency of the Company. These are primarily US Dollars (USD), Euros (EUR) and Swiss Francs 
(CHF). Transactions outside of these currencies are limited. 

The Group may use forward exchange contracts as an economic hedge against currency risk, where cash flow can be 
judged with reasonable certainty. Foreign exchange swaps and options may be used to hedge foreign currency receipts in 
the event that the timing of the receipt is less certain. There were no open forward contracts as at 31 December 2015 or at 
31 December 2014 and the Group did not enter into any such contracts during 2015 or 2014. 

4D pharma plc Annual Report and Financial Statements 2015 

41 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Financial Statements continued 
For the year ended 31 December 2015 

23. Financial risk management continued 
Foreign currency risk continued 
The split of Group assets between Sterling and other currencies at the year end is analysed as follows: 
2015 
2014 

Group 
Cash, cash equivalents 
and deposits 
Trade and other 
payables 

GBP 
£000 

USD 
£000 

EUR 
£000 

CHF 
£000 

 Total 
£000 

GBP 
£000 

USD 
£000 

EUR 
£000 

Total 
£000 

81,520  

— 

3,921  

— 

85,441 

 31,830 

(856) 

(1,441) 

(446) 

(171) 

(2,914)  

(1,272) 

 80,664 

(1,441) 

 3,475 

(171) 

82,527 

30,558 

— 

— 

— 

— 

31,830 

(495) 

(1,767) 

(495) 

30,063 

Sensitivity analysis to movement in exchange rates 
Given the immaterial net payable balances in foreign currency, the exposure to a change in exchange rate is negligible. 

24. Related party transactions 

Key management compensation 
Fees for services provided as non-executive directors: 
Salaries and short-term benefits 
Employer’s national insurance and social security costs 

Executive directors: 
Salaries and short-term benefits 
Employer’s national insurance and social security costs 

Other key management: 
Salaries and short-term benefits 
Employer’s national insurance and social security costs 
Share-based payment charge 

Year to  
31 December 2015 
£000 

Period to  
31 December 2014 
£000 

58 
5 
63 

202 
25 
227 

241 
29 
7 
277 

70 
6 
76 

192 
22 
214 

24 
2 
— 
26 

Group 
During the year Aquarius Equity Partners Limited, an entity controlled by Duncan Peyton and Dr Alexander Stevenson, 
charged the Group £94,206 for consultancy and other office expenses (period to 31 December 2014: £155,549) and 
were owed £Nil at 31 December 2015 (31 December 2014: £26,735). 

During the year, Thomas Engelen charged the Group £9,210 for consultancy services (period to 31 December 2014: 
£15,015) and was owed £Nil at 31 December 2015 (31 December 2014: £Nil). 

In November 2012, Thomas Engelen was issued with 6,372 nil-paid shares in 4D Pharma Research Limited. On purchase 
of the remaining non-controlling interest in 4D Pharma Research Limited in March 2015 by the Company, the valuation 
clause associated with these shares was triggered at £30 per share. This resulted in a payment from the Company to 4D 
Pharma Research Limited for the outstanding value on the shares of £191,160. 

On 10 January 2014 a loan of £500,000 carrying an interest rate of 4% above Bank of England base rate was novated by 
agreement between David Norwood and Schosween 17 Limited (company registered number: 8795203) to the Company. 
This loan was repaid on 18 February 2014 by 4D pharma plc and £5,178 interest was charged. 

Company 
Transactions between 100% owned Group companies have not been disclosed as these have all been eliminated in the 
preparation of the Group financial statements. 

25. Subsequent events 
On 9 February 2016, the Company purchased the entire issued share capital of Tucana Health Limited, a company based 
in Cork in Ireland. The consideration will be satisfied by the issue of up to 1,410,603 Company shares, with 410,603 
shares to be issued upfront at a price of £7.55, being the average mid-market price of a 4D share for the five business 
days immediately preceding completion of the acquisition. The remaining consideration shares will be issued subject to 
the achievement of milestones. The directors recognise that this represents a potential contingent consideration in respect 
of the acquisition. 

A fair value assessment of the acquired assets and liabilities has not yet been completed at the date of approval of the 
Annual Report and Accounts and so a full disclosure of the valuation of the acquired assets and liabilities has not been 
made. 

4D pharma plc Annual Report and Financial Statements 2015 

42 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Notice of Annual General Meeting  

4D pharma plc 
(Incorporated and registered in England and Wales with registered number 08840579) 

Notice is hereby given that the Annual General Meeting of 4D pharma plc will be held at the Gridiron Building, 1 Pancras 
Square, London N1C 4AG on 23 May 2016 at 2 p.m. for the purpose of considering and, if thought fit, passing the 
following resolutions, of which resolutions 1 to 5 will be proposed as ordinary resolutions and resolutions 6 and 7 will be 
proposed as special resolutions.  

Ordinary resolutions 
1 

That the Company’s Annual Report and audited financial statements, and the reports of the directors and auditor, 
for the year ended 31 December 2015, now laid before this meeting, be and are hereby approved. 

2 

3 

4 

5 

That Duncan Peyton, who retires by rotation, be and is hereby re-elected as a director of the Company. 

That RSM UK Audit LLP be and is hereby re-appointed as auditor of the Company, to hold office until the 
conclusion of the next general meeting at which accounts are laid before the Company. 

That the directors be and they are hereby authorised to agree the remuneration of the auditor. 

That, in accordance with section 551 of the Companies Act 2006:  

5.1 

5.2  

the directors be and they are hereby generally and unconditionally authorised to exercise all the powers 
of the Company to allot equity securities (as defined in section 560 of the Companies Act 2006) up to an 
aggregate nominal value of £54,048 (approximately one-third of the Company’s issued share capital at 
the date of this notice); and 

in addition to the authority granted pursuant to subparagraph 5.1, the directors be and they are hereby 
generally and unconditionally authorised to exercise all the powers of the Company to allot equity 
securities up to an aggregate nominal value of £54,048 (approximately one-third of the Company’s 
issued share capital at the date of this notice) in connection with a rights issue offered to holders of 
equity securities and other persons who are entitled to participate, in proportion (as nearly as may be) to 
their then holdings of equity securities (or, as appropriate, the numbers of such securities which such 
other persons are for those purposes deemed to hold), subject only to such exclusions or other 
arrangements as the directors may feel necessary or expedient to deal with treasury shares, fractional 
entitlements or legal or practical problems under the laws of, or the requirements of any recognised 
regulatory body of, or any stock exchange in, any territory,  

provided that both such authorities shall (unless previously revoked, varied or renewed) expire on the earlier of 
the date of the next Annual General Meeting of the Company and 23 August 2017, save that, in respect of either 
authority, the Company may before such expiry make an offer or agreement which would or might require equity 
securities to be allotted after such expiry and the directors may allot equity securities in pursuance of such an 
offer or agreement as if the authority conferred hereby had not expired. 

These authorities are in substitution for any and all authorities previously conferred upon the directors for the 
purposes of section 551 of the Companies Act 2006, without prejudice to any allotments made pursuant to the 
terms of such authorities. 

4D pharma plc Annual Report and Financial Statements 2015 

43 

 
 
 
 
 
 
 
 
 
 
 
 
 
Notice of Annual General Meeting continued 

Special resolutions 
6 

That, conditionally upon the passing of resolution 5 above, in accordance with sections 570 and 573 of the 
Companies Act 2006, the directors be and they are hereby given power to allot equity securities (as defined in 
section 560 of the Companies Act 2006) pursuant to the authority conferred by resolution 5 above, and to sell 
treasury shares, as if section 561 of the Companies Act 2006 did not apply to such allotment or sale, provided 
that this power shall be limited to:  

6.1 

the allotment or sale of equity securities for cash in connection with or pursuant to an offer to the holders 
of equity securities and other persons entitled to participate, in proportion (as nearly as may be) to their 
then holdings of equity securities (or, as appropriate, the numbers of such securities which such other 
persons are for those purposes deemed to hold), subject only to such exclusions or other arrangements 
as the directors may feel necessary or expedient to deal with treasury shares, fractional entitlements or 
legal or practical problems under the laws of, or the requirements of any recognised regulatory body of, 
or any stock exchange in, any territory; and 

6.2  

the allotment or sale of equity securities (otherwise than pursuant to subparagraph 6.1) for cash up to a 
maximum nominal value of £16,215 (approximately 10% of the Company’s issued share capital at the 
date of this notice),  

and shall (unless previously revoked, varied or renewed) expire on the earlier of the date of the next Annual 
General Meeting of the Company and 23 August 2017, save that the Company may before such expiry make an 
offer or agreement which would or might require equity securities to be allotted or sold after such expiry and the 
directors may allot or sell equity securities in pursuance of such an offer or agreement as if the power conferred 
hereby had not expired.  

7 

That the Company be and is hereby generally authorised pursuant to section 701 of the Companies Act 2006 to 
make market purchases (as defined in section 693(4) of the Companies Act 2006) of its ordinary shares of 0.25 
pence provided that: 

7.1  

7.2  

7.3  

the Company does not purchase more than 9,722,236 ordinary shares of 0.25 pence (approximately 
14.99% of the Company’s issued share capital at the date of this notice); 

the Company does not pay for any such ordinary share less than its nominal value at the time of 
purchase; and 

the Company does not pay for any such ordinary share more than 5% above the average of the closing 
mid-market price for ordinary shares of 0.25 pence for the five business days immediately preceding the 
date on which the Company agrees to buy the shares concerned, based on the share prices published 
in the Daily Official List of the London Stock Exchange or the AIM supplement thereto. 

The authority conferred by this resolution shall (unless previously revoked, varied or renewed) expire on the 
earlier of the date of the next Annual General Meeting of the Company and 23 August 2017, save that the 
Company may before such expiry make a contract to purchase shares which will or may be executed wholly or 
partly after the expiry of such authority, and may make a purchase of shares in pursuance of any such contract, 
as if such authority had not expired. 

By order of the Board 

Laurence Dale  
Company Secretary 
Registered office 
Third Floor 
9 Bond Court 
Leeds LS1 2JZ 

18 April 2016 

4D pharma plc Annual Report and Financial Statements 2015 

44 

 
 
 
 
 
 
 
 
 
 
 
 
Notes to the Notice of Annual General Meeting 

1. 

2. 

3. 

4. 

5. 

6. 

A member entitled to attend and vote at the meeting is also entitled to appoint one or more proxies of their own 
choice to exercise all or any of their rights to attend, speak and vote on their behalf at the meeting. A member 
can only appoint a proxy using the procedures set out in these notes and the notes to the accompanying form of 
proxy. 

A member may appoint more than one proxy in relation to the meeting provided that each proxy is appointed to 
exercise the rights attached to a different share or shares held by that member. A member may not appoint more 
than one proxy to exercise rights attached to any one share. The proxy need not be a member of the Company, 
but must attend the meeting to represent the member. Please refer to the notes to the form of proxy for further 
information on appointing a proxy, including how to appoint multiple proxies. 

In the absence of instructions, the person appointed proxy may vote or abstain from voting as he/she thinks fit on 
the specified resolutions and, unless otherwise instructed, may also vote or abstain from voting on any other 
matter (including amendments to the resolutions) which may properly come before the meeting. 

In the case of joint holders of a share, the vote of the senior who tenders a vote, whether in person or by proxy, 
shall be accepted to the exclusion of the votes of the other joint holders. For this purpose, seniority is determined 
by the order in which the names of the holders stand in the Company’s register of members in respect of the 
joint holding. 

Any corporation which is a member can appoint one or more corporate representative who may exercise on 
its behalf all of its powers as a member, provided that each representative is appointed to exercise the rights 
attached to a different share or shares held by the member. 

Pursuant to regulation 41 of the Uncertificated Securities Regulations 2001 (as amended), the Company 
specifies that only those members registered on the register of members at 6.00 p.m. on 19 May 2016 (the 
“Specified Time”) (or if the meeting is adjourned to a time more than 48 hours after the Specified Time, taking no 
account of any part of a day that is not a working day, by 6.00 p.m. on the day which is two working days prior to 
the time of the adjourned meeting) shall be entitled to attend and vote thereat in respect of the number of shares 
registered in their name at that time. If the meeting is adjourned to a time not more than 48 hours after the 
Specified Time (taking no account of any part of a day that is not a working day), that time will also apply for the 
purposes of determining the entitlement of members to attend and vote (and for the purposes of determining the 
number of votes they may cast) at the adjourned meeting. Changes to the register after the relevant deadline 
shall be disregarded in determining rights to attend and vote.  

Appointment of proxy using hard copy proxy form 
7. 

Members may appoint a proxy or proxies by completing and returning a form of proxy by post to the offices of the 
Company’s registrar using the accompanying reply-paid envelope; or in an envelope addressed to Capita Asset 
Services, PXS, 34 Beckenham Road, Beckenham, Kent BR3 4TU; or by delivering a form of proxy by hand to 
such address during normal business hours. In the case of a member which is a corporation, the proxy form must 
be executed under its common seal or signed on its behalf by a duly authorised officer or an attorney. Any power 
of attorney or any other authority under which the proxy form is signed (or a copy of such power of authority 
certified in accordance with the Powers of Attorney Act 1971) must be included with the proxy form. Any such 
power of attorney or other authority cannot be submitted electronically. 

8. 

To be effective, the appointment of a proxy, or the amendment to the instructions given for a previously appointed 
proxy, must be received by the Company’s registrar by the method outlined in note 7 above no later than 2 p.m.  
on 19 May 2016. If you submit more than one valid proxy appointment, the appointment received last before the 
latest time for the receipt of proxies will take precedence. 

Appointment of proxy using CREST electronic proxy appointment service 
9. 

CREST members who wish to appoint a proxy or proxies by utilising the CREST electronic proxy appointment 
service may do so for the meeting and any adjournment(s) of it by using the procedures described in the CREST 
Manual (available from www.euroclear.com/site/public/EUI). CREST Personal Members or other CREST 
sponsored members, and those CREST members who have appointed a voting service provider(s), should 
refer to their CREST sponsor or voting service provider(s), who will be able to take the appropriate action on 
their behalf. 

10. 

In order for a proxy appointment made by means of CREST to be valid, the appropriate CREST message (a 
“CREST Proxy Instruction”) must be properly authenticated in accordance with Euroclear UK & Ireland Limited’s 
(“EUI’s”) specifications and must contain the information required for such instructions, as described in the 
CREST Manual. The message must be transmitted so as to be received by the issuer’s agent (ID: RA10) by the 
latest time(s) for receipt of proxy appointments specified in this notice. For this purpose, the time of receipt will be 
taken to be the time (as determined by the timestamp applied to the message by the CREST Applications Host) 
from which the issuer’s agent is able to retrieve the message by enquiry to CREST in the manner prescribed 
by CREST. 

4D pharma plc Annual Report and Financial Statements 2015 

45 

 
 
 
 
 
 
 
 
 
 
Notes to the notice of Annual General Meeting continued 

Appointment of proxy using CREST electronic proxy appointment service continued 
11. 

CREST members and, where applicable, their CREST sponsors or voting service providers should note that EUI 
does not make available special procedures in CREST for any particular messages. Normal system timings and 
limitations will therefore apply in relation to the input of CREST Proxy Instructions. It is the responsibility of the 
CREST member concerned to take (or, if the CREST member is a CREST personal member or sponsored 
member or has appointed (a) voting service provider(s), to procure that his CREST sponsor or voting service 
provider(s) take(s)) such action as shall be necessary to ensure that a message is transmitted by means of the 
CREST system by any particular time. In this connection, CREST members and, where applicable, their CREST 
sponsors or voting service providers are referred, in particular, to those sections of the CREST Manual 
concerning practical limitations of the CREST system and timings. 

12. 

The Company may treat as invalid a CREST Proxy Instruction in the circumstances set out in Regulation 35(5)(a) 
of the Uncertificated Securities Regulations 2001. 

Termination of proxy appointments 
13. 

Completion and return of the form of proxy will not preclude a member from attending and voting in person at 
the meeting. 

14. 

In order to terminate the authority of a proxy, you will need to inform the Company by sending a signed hard copy 
notice clearly stating your intention to revoke such appointment to the Company’s registrar. To be effective, the 
notice of termination must be received by the Company’s registrar by the method outlined in note 7 above no 
later than 2 p.m. on 20 May 2016. 

Voting rights 
15. 

As at 18 April 2016, being the latest practicable date prior to the printing of this notice, the Company’s issued 
capital consisted of 64,858,150 ordinary shares carrying one vote each. Therefore, the total voting rights in the 
Company as at 18 April 2016 are 64,858,150. 

Communications 
16. 

This notice, together with information about the total number of shares in the Company in respect of which 
members are entitled to exercise voting rights at the meeting as at 18 April 2016, being the latest practicable date 
prior to the printing of this notice, will be available on the Company’s website, www.4dpharmaplc.com. 

17. 

Except as provided above, members who have general queries about the Annual General Meeting should 
contact Laurence Dale (0113 895 0130; Third Floor, 9 Bond Court, Leeds LS1 2JZ). No other methods of 
communication will be accepted. Any electronic address provided either in this notice or in any related documents 
(including the form of proxy) may not be used to communicate with the Company for any purposes other than 
those expressly stated. 

Documents available for inspection 
18. 

There are available for inspection at the registered office of the Company during usual business hours on any 
weekday (public holidays excepted), and there will be available for inspection at the place of the meeting from at 
least 15 minutes prior to and until the conclusion of the meeting: 

 

 

copies of the service contracts of Executive directors of the Company; and 

copies of the letters of appointment of the non-executive directors of the Company. 

4D pharma plc Annual Report and Financial Statements 2015 

46 

 
 
 
 
 
 
 
 
 
 
 
 
Explanatory Notes to the Notice of Annual General Meeting 

These explanatory notes give further information in relation to the resolutions listed in the enclosed notice of the 
Company’s Annual General Meeting. 

Resolution 1 – Receipt of accounts 
The directors must lay the Company’s accounts, the Directors’ Report and the Auditor’s Report before the shareholders at 
a general meeting. This is a legal requirement after the directors have approved the accounts and the Directors’ Report, 
and the auditor has prepared its report. 

Resolution 2 – Re-election of Duncan Peyton 
In accordance with the Company’s articles of association, all directors of the Company who have been appointed since the 
Company’s last Annual General Meeting, and all other directors on a regular basis as set out in the Company’s articles of 
association, seek election (or re-election as the case may be) by the shareholders. 

Duncan Peyton, retiring by rotation, offers himself for re-election, in accordance with the Company’s articles of 
association. Details of his CV are on page 6 of the Company’s Annual Report. 

Resolution 3 – Re-election of RSM UK Audit LLP as auditor 
The Board of directors, on the recommendation of its Audit and Risk Committee, recommends the re-election of RSM UK 
Audit LLP as auditor, to hold office until the next general meeting at which accounts are laid. 

Resolution 4 – Remuneration of the auditor 
This resolution authorises the directors to agree the remuneration of the auditor. 

Resolution 5 – Authority to allot shares 
The purpose of resolution 5 is to renew the directors’ power to allot shares. Section 551 of the Companies Act 2006 
provides that the directors may not allot new shares (other than for employee share schemes) without 
shareholder authority. 

Accordingly, resolution 5 will be proposed as an ordinary resolution to authorise the directors (pursuant to section 551 
of the Companies Act 2006): 

(i) 

(ii) 

to allot ordinary shares of 0.25 pence each in the capital of the Company up to a maximum nominal amount of 
£54,048, being approximately one-third of the nominal value of the ordinary shares in issue on 18 April 2016; and 

in addition to the authority described above, to allot ordinary shares of 0.25 pence each in the capital of the 
Company up to a maximum nominal amount of £54,048 pursuant to a rights issue in respect of which all 
shareholders are entitled to participate as nearly as possible in proportion to their holding of shares in the 
Company at the time. 

This authority (unless previously revoked, varied or renewed) will expire on the earlier of the date of the next Annual 
General Meeting of the Company or 15 months after the date of the passing of the resolution. The directors will exercise 
the authority to allot only when satisfied that it is in the interests of the Company to do so. The directors have no present 
intention of allotting further shares. 

Were the Company to use the relevant authorities and: 

 

 

the number of shares in issue increased, in aggregate, by more than one-third; and 

(as regards their use as a part of a rights issue) the proceeds of the relevant rights issue exceeded one-third 
(or the relevant specific proportion) of the pre-issue market capitalisation,  

then those members of the Board wishing to remain in office would stand for re-election at the next Annual 
General Meeting.  

4D pharma plc Annual Report and Financial Statements 2015 

47 

 
 
 
 
 
 
 
 
 
 
 
 
Explanatory notes to the notice of Annual General Meeting  
continued 

Resolution 6 – Disapplication of pre-emption rights 
Section 561 of the Companies Act 2006 confers on shareholders’ rights of pre-emption in respect of the allotment of 
“equity securities” which are, or are to be, paid up in cash, otherwise than by way of allotment to employees under an 
employees’ share scheme. The provisions of section 561 apply to the ordinary shares of 0.25 pence each of the 
Company, to the extent that they are not disapplied pursuant to section 570 of the Companies Act 2006. This provision 
also covers the sale of treasury shares (should the Company elect to hold any) for cash. 

It is proposed that the disapplication of these statutory pre-emption rights be approved, as a special resolution, to give the 
directors power to allot shares without the application of these statutory pre-emption rights, first, in relation to rights issues 
and, second, in relation to the issue of ordinary shares of 0.25 pence each in the capital of the Company for cash up to a 
maximum aggregate nominal amount of £16,215 (representing approximately 10% of the nominal value of the ordinary 
shares in issue on 18 April 2016). 

This authority (unless previously revoked, varied or renewed) will expire on the earlier of the date of the next Annual 
General Meeting of the Company or 15 months after the date of the passing of the resolution. 

The directors have no present intention of exercising the authority; in accordance with the National Association of Pension 
Funds’ Corporate Governance Policy and Voting Guidelines for Smaller Companies, they are seeking the authority so as 
to be able to raise funds at short notice, where appropriate, from the issue of new share capital for the purpose of taking 
advantage of investment opportunities that may arise. 

Resolution 7 – Purchase by the Company of its own shares 
The purpose of resolution 7 is to obtain the authority for the Company to make market purchases of its ordinary shares. 
Under the Companies Act 2006 such an authority must first be sanctioned by an ordinary resolution of the Company in 
general meeting, but current institutional shareholder voting guidelines require that any such authority should be 
sanctioned by special resolution. 

Accordingly, resolution 7 will be proposed as a special resolution to authorise the Company to purchase a maximum of 
9,722,236 ordinary shares (equal to approximately 14.99% of the ordinary shares in issue on 18 April 2016) on AIM at a 
price per share of not less than 0.25 pence, and not more than 5% above the average of the middle market quotations for 
ordinary shares of the Company for the five business days immediately preceding the day of purchase. In order to 
maximise the benefit to be derived by the Company, it would be the directors’ intention that any purchases should be 
made at as low a price (within the limits specified in resolution 7) as they considered reasonably obtainable. 

This authority (unless previously revoked, varied or renewed) will expire on the earlier of the date of the next Annual 
General Meeting of the Company or 15 months after the date of the passing of the resolution. 

Pursuant to the Companies Act 2006, the Company can hold the shares which have been repurchased as treasury shares 
and either resell them for cash, cancel them (either immediately or at a point in the future) or use them for the purposes of 
its employee share schemes. The directors believe that it is desirable for the Company to have this choice and therefore 
currently envisage holding any shares purchased under this authority as treasury shares. Holding the repurchased shares 
as treasury shares will give the Company the ability to resell or transfer them in the future, and so provide the Company 
with additional flexibility in the management of its capital base. No dividends will be paid on, and no voting rights will be 
exercised in respect of, treasury shares. 

Shares will only be repurchased if the directors consider such purchases to be in the best interests of shareholders 
generally and that they can be expected to result in an increase in earnings per share. The authority will only be used after 
careful consideration, taking into account market conditions prevailing at the time, other investment opportunities and the 
overall financial position of the Company. Shares held as treasury shares will not automatically be cancelled and will not 
be taken into account in future calculations of earnings per share (unless they are subsequently resold or transferred out 
of treasury). 

If any shares repurchased by the Company are held in treasury and used for the purposes of its employee share 
schemes, while so required under institutional shareholder voting guidelines, the Company will count those shares 
towards the limits on the number of new shares which may be issued under such schemes. 

Purchases will not be made to the extent that they may affect the eligibility of the Company for continued admission to AIM 
and it is not the directors’ current intention that the Company should stand in the market for any particular year or until any 
specified number of shares has been acquired. 

The purchase of shares by the Company pursuant to these proposals will be a market purchase and thus made through 
AIM. This means that any shareholder selling shares, even if those shares are subsequently acquired by the Company, 
will not be subject to different tax considerations from those normally applying to a sale of shares in the market provided 
that the purchase by the Company is made exclusively through a market maker acting as principal. In that event, for 
shareholders who held their shares as an investment, the sale proceeds will normally be treated as capital and the normal 
capital gains tax rules will apply to those sale shares. There will normally be no liability to tax on income unless the 
shareholder’s disposal is by way of trade. 

4D pharma plc Annual Report and Financial Statements 2015 

48