Bio-Rad Laboratories Annual Report 2006

Plain-text annual report

Path to Health Bio-Rad LaboratoriesAnnual Report 2006If the journey is indeed the reward, we are fortunate to be traveling during an auspicious time in the field of healthcare. On this path, each point along the way represents a step of hope, each advancement a higher quality of life for patients. Today, with the promise of genetic discov- ery and improved diagnostic tech- Health niques, this path- way is offering new routes to suc- cessful outcomes. At Bio-Rad, we are an integral part of this journey, helping researchers and diagnosticians continually reach innovative and important milestones for improving the way diseases are understood, managed, and, in some cases, completely eradicated. Bio-Rad Laboratories | Annual Report 2006 Letter to Shareholders 2006 was another year of growth and progress on many fronts for Bio-Rad. From a financial perspective, in spite of slowed life sciences markets in both the US and Japan, diagnostics cost containment measures, and reduced BSE (mad cow) revenue, we posted an 8% sales growth for the year and increased our net income over 26%. A few key events throughout the year helped to enhance these results, including a large equipment order in Russia as well as gains from the settlement of a long-stand- ing royalty dispute. Our improved financial performance is due in large part, however, to the delivery of new and exciting prod- ucts and our continued focus on the needs of our customers. We had a number of projects on our list in 2006. Key among them was the realignment of our selling and distribu- tion functions throughout Europe. This was undertaken with 2 goals in mind: first, to improve customer service, and second, to increase the effectiveness and efficiency of our organization across this region. To date, much of what we set out to do has been completed, leaving us well-positioned to realize the benefits of this project in the coming years. The year also saw several new organi- zations become part of Bio-Rad. After many years of discussion, Blackhawk BioSystems joined us, bringing expertise and products in the area of quality con- trol. The company’s offering of infectious disease controls is complementary to our current product line, enhancing our lead- ership position in an important segment of the diagnostic market. We also broadened our diabetes focus with the addition of Provalis point-of-care products for this market and the osteoporo- sis area. Point-of-care diagnostics is an area of increasing interest to healthcare provid- ers as they seek to streamline patient care. In the fourth quarter, we were able to make an important addition to our life sci- ence product group with the purchase of Ciphergen’s SELDI technology for protein analysis. This is, again, complementary to our current suite of products. The under- p2 Bio-Rad Laboratories | Annual Report 2006 standing of proteins and their function will take center stage for many years to come as scientists seek to discover the basis of dis- ease and, ultimately, its cures. Another mile- stone in the pro- tein arena was the introduction of the ProteOn™ system for understanding protein interac- tions, an increas- ingly important fo- cus of research. We also entered into a collaboration with Integrated DNA Technologies to develop validated RNA interference (RNAi) reagents for the growing area of gene silencing. After many years in development, we be- gan placing BioPlex® 2200 systems in diag- nostic labs. Reception to this new technol- ogy has been pleasing and we are working to expand the range of tests available on this system to broaden its market. The year ended on a sad note as Philip Padou, a longtime member of our Board, died suddenly in December. Phil was a dedicated and valuable member of our board for almost 30 years. We will miss him and are grateful for his many years of service. Throughout the year, we strength- ened our offer- ings in a variety of product areas in the healthcare market that enhanced our positions along the “path to health”— our theme for this year’s annual report. While 2006 was a productive year, we now have our sights set on 2007 and look forward to a new year. David Schwartz Chairman of the Board Norman Schwartz President p3 research + discover + diagnose + treat + monitor = Bio-Rad Laboratories | Annual Report 2006 The continuum of healthcare is marked by a long and deliberate journey, with critical work being done at every step along the way. Bio-Rad Laboratories is proud to partner with scientists, clinicians, and physicians to Health make this path as productive as possible for these practitioners — professionals whose job it is to see that the ultimate beneficiaries of this process, the patients themselves, truly remain on the road to good health. p Bio-Rad Laboratories | Annual Report 2006 It is, in short, the discipline we use to understand how the human body works … and how it sometimes doesn’t. Life science research allows us to literally look inside ourselves, discovering the systems, processes, and structure of living organisms and their component systems. When we look inside, we find that the interactions among the body’s thousands of proteins — highly complex compounds found in all living cells — play a significant and central role in determin- ing the progression of disease. The discovery and characterizations of proteins, however, is only the first step in learning how these compounds participate in a biological process. How they function and interact with each other is the key to under- standing disease. Until recently, scientists could look only at the narrowest of these in- teractions, unable to ask the more complex ques- tions essential to understanding the intricate pro- tein combinations that define all cellular processes. Today, this situation is changing rapidly, thanks to advances in technology that allow researchers to observe more than one protein interaction at a time. Bio-Rad’s dedicated efforts in this area offer researchers the ability to measure up to 36 simulta- neous protein interactions. As a result, more exper- iments can be run in a shorter period of time and produce richer results in characterizing the role of proteins in biological processes. Going beyond the ex- amination of interactions among multiple proteins, examining the relation- ships among molecules within a single protein takes on increased im- portance. This allows re- searchers to work on dif- ferent parts of a single life cycle. With “interferons,” for example (a family of immune proteins that is produced in response to viruses, bacteria, parasites, and tumor cells), work may be done simultane- ously to understand both the natural production of different types of interferons in response to foreign agents and the therapeutic use of these proteins to treat diseases such as cancer, hepatitis C, and multiple sclerosis. By seeing the big picture, instead of isolated little ones, researchers are coming ever closer to un- derstanding the interactions that can lead to cures. The ProteOn™ XPR36 Protein Interaction Array System fig. 1: Based on surface plasmon resonance technology, the ProteOn™ XPR36 Protein Interaction Array System is an optical biosensor that uses im- age analysis to simultaneously track optical changes at many different sites in an image (array) enabling the measurement of up to 36 interactions at a time. p6 fig. 1research David Myszka, an expert in the field of optical biosensors, is the Director of the Center for Biomolecular Interaction Analysis at the University of Utah, in Salt Lake City, where he studies protein interactions in collaboration with researchers on campus and for biotech and pharmaceutical companies across the country. David uses the Bio-Rad ProteOn XPR36 system for its speed and accuracy, its ease-of-use, and its complete package of instruments, kits, reagents, software, support, and training. discover Brian Gardner, a Research Assistant at the UCLA School of Medicine’s Division of Pulmonary Critical Care, in Los Angeles, California, looks at plasma and serum obtained from patients with lung cancer and compares them to at-risk individuals and those considered not at risk for contracting the disease. Brian uses the ProteinChip® SELDI System for the greater flexibility advantages its surface enhancement technology gives him over other technologies. Bio-Rad Laboratories | Annual Report 2006 Before we attempt to find the needle, we’ve got to know which haystack to look in. Biomarker discovery is the science of screening for, and identifying, the warning signs of a wide range of disease states. Today, advances in biomarker discovery are their structures and functions), SELDI enables accelerating new hope in the early detection of often researchers to detect and precisely calculate the mass debilitating diseases such as Alzheimer’s disease and of proteins and peptides from complex biological cancer. A former smoker, for example, is typically samples through a unique process that identifies diagnosed with lung cancer only after the first symptoms — such as a persistent cough — have appeared. But by then it may be too late. If it were possible to determine, early on, a patient’s risk factors for developing lung can- cer, preventive measures might be taken, with the odds high for a drasti- cally different outcome. An exciting technology The ProteinChip® SELDI System different protein subsets on the surface of a chip. Comparing the results of such protein mea- surements among vari- ous populations — for example, diseased-state lung cancer patients compared to those con- sidered at high risk — leads to informed judg- ment about the degree to which a patient might be likely to contract cancer in the future. identifying this kind of early warning sign Technologies such as these are helpful because they is called Surface-Enhanced Laser Desorption/ allow researchers to see the widest concentration Ionization (SELDI), which is accelerating bio- of proteins in the blood, increasing the possibility marker discovery. Used for clinical and research of detecting all types of disease agents that may proteomics (the study of proteins, in particular eventually lead to the development of cancer. fig. 2: The ProteinChip® SELDI System employs patented Surface- Enhanced Laser Desorption/Ionization that enables differential protein expression. Proteomics research provides a direct approach to understanding the role of proteins in the biology of disease, monitoring disease progression and increasing the therapeutic effects of drugs. p fig. 2Bio-Rad Laboratories | Annual Report 2006 Once the markers are found, it remains to measure them, to identify their partic- ular brand of biological malfeasance. With this information, we are able to give the disease a name — and thus guide the clinician on the path to treatment. In-vitro diagnostics are designed to quantify biological markers of interest in order to determine whether or not a particular therapeutic inter- vention is appropriate. These markers include autoimmune diseases such as lupus and rheumatoid arthritis, genetic disorders like sickle cell anemia, and infectious diseases such as AIDS and Epstein- Barr Virus. Recent advances in the area of multiplex analysis have given di- agnostic labs the abil- ity to generate multiple results from a single patient sample and are transforming diagnostic testing for autoimmune disorders and allergies, infectious diseases, genetically inherited diseases, and toxicology. This means that labs are able to perform more tests in less time and with less labor, thus dramatically improving productivity. As a result, clinicians are able to provide test results more quickly to physicians, who in turn can make critical treatment decisions earlier in a disease state. With a diagnostic test for Antinuclear Antibodies (ANA), for example, knowing whether or not auto-antibodies are positive gives a physician a significant head start on treating his or her patient, thus enhancing the ultimate quality of the patient’s life. Multiplexing also allows for the simultaneous interpretation of data. In the world of auto- immune screening, for example, clinicians are able to test up to 11 different auto-antibodies at the same time, gener- ating results that can be analyzed more quickly to produce an antibody “profile,” offering additional information to a physician about other possible diseases to consider. The BioPlex® 2200 System fig. 3: The BioPlex® 2200 system is the first and only fully automated, random access multiplex testing platform to generate multiple results from a single patient sample. Used with accompanying interpretive software, the system represents a breakthrough in clinical diagnostic technology. p10 fig. 3diagnose Denise Facaros is a Laboratory Manager at Healthcare Clinical Laboratories in Stockton, California, where her responsibilities include the diagnostic testing of a wide variety of markers, including ANA, for autoimmune disease. Denise depends on the BioPlex 2200 system for its fully automated, quick, and accurate results. treat Dr. Secily Bason-Mitchell is an OB/GYN at the Pacific Women’s Obstetrics and Gynecology Medical Group in San Francisco, California. She spends a lot of time with teens, talking about pressing health issues such as birth control, sexually transmitted diseases, cervical cancer, and the importance of getting regular good health checkups. Bio-Rad Laboratories | Annual Report 2006 We know the problem; we can now apply the solution. Today, biomedical treatment allows us to improve the existing condition, or — even better — prevent it from ever occurring in the first place. Over the course of the past quarter century, the paradigm for disease treatment in modern biology has changed drastically. Past treat- ments were limited to very general regimens, but today’s more detailed biomarker iden- tification processes are leading to highly specific and focused treatment applications. These technologies are based on advances in modern biology. The beneficial effect allows physicians to help their patients become more proactive, by enabling those patients to lit- erally take charge of critical areas of their healthcare futures. Bio-Rad offers a variety of solu- tions for the production of biotherapeutics. One product offering in the area of process chromatog- raphy is now a critical component of an innovative treatment for inoperable colorectal liver cancer. This minimally invasive form of therapy has been successful at extending the lives of more than 3,40 liver cancer patients in the United States alone since the introduction of the treatment in 2002. Similar technologies and products provide more effective treatment — and in some cases, even the prevention of — common ailments including dia- betes, genetic disor- ders, hemophilia, men- ingitis, and cancer. In diabetes treatments, a Bio-Rad purification product has become a key component in the manufacture of an innovative new inhal- able insulin product that offers great promise for the management of blood sugar levels. In the future, with increasingly detailed and insightful information into human biomarkers, we can expect to see ever more focused therapies, and ever more targeted treatments. CHT™ Ceramic Hydroxyapatite fig. 4: CHT™ Ceramic Hydroxyapatite is just one example of Bio-Rad purification products. It is used in the purification stages in the manufacture of a variety of therapies and vaccines for diabetes, cancer, meningitis, genetic disorders, and other diseases. p13 fig. 4Bio-Rad Laboratories | Annual Report 2006 Like a status check in virtually any field of endeavor, the accuracy of a monitoring process often depends on an array of highly specific, sensi- tive, and precise tests. In the biomedical field, such tests quantify levels or percentages of a prede- termined marker in a patient sample. These results are then com- pared with established ranges to determine if the patient needs ad- justment to his or her treatment, in the form of changes in medica- tion, diet, or exercise. tions of diabetes, including blindness, kidney failure, and lower limb amputation. In addition, a variety of high performance liquid chroma- tography (HPLC) products are used to monitor therapeutic drugs such as benzodiazepines and tricyclics, which are prescribed for depres- sion. Monitoring the levels of these prescrip- tion drugs aids a phy- sician in increasing the efficacy of the drugs and avoiding cardio and central nervous system toxicity. VARIANT™ II TURBO Hemoglobin Testing System Instruments such as in Bio-Rad’s those broad range of moni- toring products help physicians in many ways. By using a Bio-Rad A1c diabetes monitoring assay, for example, physicians have a trusted resource for monitor- ing a patient’s blood glucose levels over time. By maintaining hemoglobin A1c levels as rec- ommended, a patient can reduce the complica- In the future, the im- portance of monitor- ing will increase as our knowledge of disease management and its associated markers ex- pands. From monitoring multiple markers for the same disease to associating a specific mark- er to multiple conditions or even multiple uses, tomorrow’s disease states will have ever more vigilant eyes upon them. fig. 5: The VARIANT™ II TURBO Hemoglobin Testing System offers a great combination of throughput, efficiency and quality of results — all in one package. Walk-away automation minimizes cost and streamlines workflow. p14 Is it working? Is the regimen that the doctor prescribed effective? And how can one be sure? By monitoring a patient’s specific markers — with sensitivity, specificity, and precision — caregivers can adjust treatment to continually improve the quality of life.fig. 5monitor In her capacity as Laboratory Administrator at the Advanced Medical Analysis Laboratory in Monrovia, California, Mina Ison is responsible for the activities concerned with establishing, validating, and verifying that testing services meet customer needs and regulatory requirements. The VARIANT II TURBO Hemoglobin Testing System meets Mina’s demand for an A1c test system that combines ease of operation, speed of testing, quality, and accuracy of results. Bio-Rad Laboratories | Annual Report 2006 The Business of Bio-Rad Bio-Rad Laboratories has played a leading role in the advance- ment of scientific discovery for over 0 years by providing a broad range of innovative tools and services to the life science research and clinical diagnostics markets. Founded in 12 and incorporated in 17, Bio-Rad has a global team of more than ,000 employees and serves more than 8,000 research and industry customers worldwide through its global network of operations. Throughout its existence, Bio-Rad has built strong customer relationships that advance scientific research and development efforts and support the introduction of new technology used in the growing fields of genomics, proteomics, drug discovery, food safety, medical diagnostics, and more. LIFE SCI ENCES Bio-Rad’s Life Science Group develops, manu- factures, and markets a wide range of labora- tory instruments, apparatus, and consumables used for research in functional genomics, pro- teomics, and food safety. The group ranks among the top life science companies world- wide, and maintains a solid reputation for quality, innovation, and commitment to its customers. Bio-Rad’s life science products are based on technologies used to identify, separate, purify, and analyze biological materials such as proteins and nucleic acids. Some of these technologies include electrophoresis, imaging, multiplex immunoassay, chromatography, microbiology, bioinformatics, protein function analysis, transfection, amplification, and real- time PCR. Bio-Rad products support researchers in laboratories throughout the world. CLINICAL DIAGNOSTIC S Clinical Diagnostics develops, manufactures, sells, and supports a large portfolio of products for medical screening and diagnostics. Bio-Rad is the number one specialty diagnostic company in the world and its products are recognized as the gold standard for diabetes monitoring and broad-spectrum screening. The company is also well known for its quality control (QC) systems, blood virus testing and detection, toxicology, genetic disorders testing, specialty chemistry, molecular pathology, and internet-based soft- ware products. Bio-Rad’s clinical diagnostics products incorporate a broad range of technolo- gies used to detect, identify, and quantify sub- stances in bodily fluids and tissues. The results are used as aids for medical diagnosis, detection, evaluation, and the monitoring and treatment of diseases and other medical conditions. p16 Bio-Rad Laboratories | Annual Report 2006 D-10™ Hemoglobin Testing System Crime Scene Investigator PCR Basics™ Kit Unity Desktop™ software Lyphochek® Immunoassay Plus Control Profina™ Purification System ANA Screening Test HIV-1/HIV-2 PLUS O EIA Mini-PROTEAN® Tetra Cell RAPID’E.coli 2™ Chromogenic Media With a portfolio consisting of over 8,000 products, Bio-Rad provides products for discovery and diagnostic tests for biological exploration and clinical diagnostics. The company is renowned worldwide among hospitals, universities, and major research institutions, as well as biotechnology and pharmaceutical companies for its commitment to quality and customer service. p17 Bio-Rad Laboratories | Annual Report 2006 On the path to health. With much promising work being done in the fields of life science and clinical diagnostics, the outlook — in the face of today’s diseases — for continued improvement in our basic quality of life remains encouraging. From helping researchers gain a better understanding of the nature of illness to supporting clinicians who determine effective treat- ment, Bio-Rad is proud to be an active participant in these efforts, opening up new avenues in innovation at every step along the way. This journey, more than half a century in the making, has accelerated the pace of scientific discovery, resulting in numerous advancements in medicine through the years, as well as in the greatest reward of all: a pathway to health. p18 Bio-Rad Laboratories | Annual Report 2006 Financial Highlights Five-Year Record 2002 2003 2004 2005 2006 (in millions, except per share data) Net Sales Gross Profit $ 86.0 $ 7.6 $ 1,00.0 $ 1,181.0 $ 1,273. $ 4.6 $ 6.2 $ 610.1 $ 646. $ 712. Research Expenditures(1) $ 7.8 $ 1.3 $ 108.3 $ 11.1 $ 123.4 Net Income Return On Sales $ 67. $ 76.2 $ 68.2 $ 81.6 $ 103.3 7.8% 7.8% 6.3% 6.% 8.1% Book Value Per Share $ 1.17 $ 1.41 $ 23.10 $ 2.0 $ 30.2 Basic Earnings Per Share $ 2.70 $ 3.00 $ 2.6 $ 3.13 $ 3.2 Cash Flow from Operations $ 10.8 $ 127.6 $ 123.1 $ 108.3 $ 118.2 (1) Excludes $14.6 and $4.1 of purchased R&D in 2004 and 2006, respectively. 2006 Sales by Region Net Sales (in millions) Cash Flow From Operations (in millions) Basic Earnings Per Share 9 . 3 7 2 , 1 $ 0 . 1 8 1 , 1 $ 6 . 7 2 1 $ 1 . 3 2 1 $ 2 . 8 1 1 $ 3 . 8 0 1 $ 8 . 5 0 1 $ 2 9 . 3 $ 3 1 . 3 $ 0 0 . 3 $ 0 7 . 2 $ 5 6 . 2 $ 0 . 0 9 0 , 1 $ 6 . 9 7 9 $ 0 . 5 6 8 $ 40% Americas 16% Pacific Rim 44% Europe 02 03 04 05 06 02 03 04 05 06 02 03 04 05 06 p1 Bio-Rad Laboratories | Annual Report 2006 Sales History p20 Bio-Rad Laboratories | Annual Report 2006 Summary of Operations and Selected Financial Data (in thousands, except per share data) Year Ended December 31, 2006 2005 2004 2003 2002 Net sales Cost of goods sold Gross profit $ 1,273,930 $ 1,180,985 $ 1,090,012 $ 979,631 $ 865,006 561,394 534,499 479,939 423,401 365,451 712,536 646,486 610,073 556,230 499,555 Selling, general and administrative expense 438,949 416,084 378,264 317,524 281,579 Product research and development expense 123,376 115,104 108,344 91,273 79,788 Purchased in-process research and development expense 4,100 — 14,620 Impairment losses on long-lived assets — 19,770 — — — — — Interest expense Foreign exchange (gains) losses Other (income) expense, net (1) 32,022 32,643 20,219 31,006 28,207 1,053 (1,528) 2,394 4,080 5,441 (28,991) (28,958) (11,095) (3,012) (678) Income from continuing operations before taxes 142,027 93,371 97,327 115,359 105,218 Provision for income taxes (38,764) (15,792) (31,035) (38,055) (36,692) Income from continuing operations 103,263 77,579 66,292 77,304 68,526 Discontinued operations Gain (loss) from discontinued operations (net of tax) Gain on divestiture (net of tax) Total income (loss) from discontinued operations Net income Basic earnings per share: Continuing operations Discontinued operations Basic earnings per share Diluted earnings per share: Continuing operations Discontinued operations Diluted earnings per share — — — — (1,487) (1,133) 3,974 3,974 3,437 — 1,950 (1,133) (663) — (663) $ 103,263 $ 81,553 $ 68,242 $ 76,171 $ 67,863 $ $ $ $ 3.92 $ 2.98 $ 2.58 $ 3.04 $ 2.73 — 0.15 0.07 (0.04) (0.03) 3.92 $ 3.13 $ 2.65 $ 3.00 $ 2.70 3.83 $ 2.91 $ 2.51 $ 2.94 $ 2.63 — 0.15 0.07 (0.04) (0.02) 3.83 $ 3.06 $ 2.58 $ 2.90 $ 2.61 Cash dividends paid per common share — — — — — Total assets $ 1,596,168 $ 1,426,582 $ 1,371,618 $ 992,596 $ 720,703 Long-term debt, net of current maturities $ 425,625 $ 425,687 $ 425,979 $ 225,835 $ 105,768 (1) See Note 11 to the consolidated financial statements for components of Other (income) expense, net. Included in 2004 is interest and investment income of $6.6 million, income from equity investee of $3.1 million and a litigation settlement of $1.9 million offset by a $2.4 million write-down of an investment. Included in 2005 is interest and investment income of $16.7 million, gains on sales of investments of $11.2 million, and litigation expense of $1.2 million. Included in 2006 is interest and investment income of $22.3 million and gains on sales of investments of $4.7 million. p21 Bio-Rad Laboratories | Annual Report 2006 Consolidated Balance Sheets (in thousands) ASSETS Current assets: Cash and cash equivalents Restricted cash Short-term investments Accounts receivable less allowance of $15,265 in 2006 and $13,301 in 2005 Inventories, net: Raw materials Work in process Finished goods Total inventories Deferred tax assets Prepaid expenses and other current assets Total current assets Property, plant and equipment: Land and improvements Buildings and leasehold improvements Equipment Total property, plant and equipment Accumulated depreciation Property, plant and equipment, net Goodwill Purchased intangibles, net Long-term deferred tax assets Other assets December 31, 2006 2005 $ 223,607 $ 296,716 — 36,138 264,473 116,343 292,970 247,192 59,356 57,682 48,271 51,601 136,007 112,470 253,045 212,342 35,862 59,820 30,984 68,496 1,129,777 1,008,211 9,577 9,837 121,977 120,015 357,600 322,354 489,154 452,206 (299,527) (271,948) 189,627 180,258 119,492 113,276 44,605 9,100 103,567 28,449 14,003 82,385 TOTAL ASSETS $ 1,596,168 $ 1,426,582 The accompanying notes are an integral part of these consolidated financial statements. p22 Bio-Rad Laboratories | Annual Report 2006 (in thousands, except share data) LIABILITIES AND STOCKHOLDERS’ EQUITY Current liabilities: Accounts payable Accrued payroll and employee benefits Notes payable Current maturities of long-term debt Sales, income and other taxes payable Litigation accrual Accrued royalties Current deferred taxes Other current liabilities Total current liabilities Long-term debt, net of current maturities Deferred tax liabilities Other long-term liabilities Total liabilities December 31, 2006 2005 $ 83,411 $ 72,950 92,101 81,076 2,539 503 19,949 8,810 31,826 2,445 77,949 2,950 391 15,841 55,701 34,386 126 55,822 319,533 319,243 425,625 425,687 7,512 23,960 2,281 21,397 776,630 768,608 Commitments and contingent liabilities — — Stockholders’ equity: Preferred stock, $0.0001 par value, 7,500,000 shares authorized; none outstanding Class A common stock, $0.0001 par value, 80,000,000 shares authorized; outstanding — 21,594,311 at 2006 and 21,316,556 at 2005 Class B common stock, $0.0001 par value, 20,000,000 shares authorized; outstanding — 4,909,908 at 2006 and 2005 Additional paid-in capital Retained earnings Accumulated other comprehensive income: Currency translation and other Total stockholders’ equity — 2 1 — 2 1 78,230 60,112 674,070 570,807 67,235 27,052 819,538 657,974 TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY $ 1,596,168 $ 1,426,582 The accompanying notes are an integral part of these consolidated financial statements. p23 Bio-Rad Laboratories | Annual Report 2006 Consolidated Statements of Income (in thousands, except per share data) Net sales Cost of goods sold Gross profit Selling, general and administrative expense Product research and development expense Purchased in-process research and development expense Impairment losses on long-lived assets Interest expense Foreign exchange (gains) losses Other income, net Income from continuing operations before taxes Provision for income taxes Income from continuing operations Discontinued operations Loss from discontinued operations net of tax benefits of $532 Gain on divestiture net of tax expense of $0 in 2005 and $2,295 in 2004 Total income from discontinued operations Net income Basic earnings per share: Continuing operations Discontinued operations Net income Weighted average common shares Diluted earnings per share: Continuing operations Discontinued operations Net income Weighted average common shares The accompanying notes are an integral part of these consolidated financial statements. Year Ended December 31, 2006 2005 2004 $ 1,273,930 $ 1,180,985 $ 1,090,012 561,394 534,499 479,939 712,536 646,486 610,073 438,949 416,084 378,264 123,376 115,104 108,344 4,100 — 32,022 1,053 (28,991) 142,027 (38,764) 103,263 — 14,620 19,770 32,643 (1,528) (28,958) 93,371 (15,792) 77,579 — 20,219 2,394 (11,095) 97,327 (31,035) 66,292 — — — — (1,487) 3,974 3,974 3,437 1,950 $ 103,263 $ 81,553 $ 68,242 $ $ $ $ 3.92 $ 2.98 $ — 0.15 3.92 $ 3.13 $ 2.58 0.07 2.65 26,376 26,063 25,724 3.83 $ 2.91 $ — 0.15 3.83 $ 3.06 $ 2.51 0.07 2.58 26,949 26,662 26,489 p24 Bio-Rad Laboratories | Annual Report 2006 Consolidated Statements of Cash Flows (in thousands) Cash flows from operating activities: Cash received from customers Cash paid to suppliers and employees Litigation settlement related to MJ acquisition Interest paid Income tax payments Miscellaneous receipts Excess tax benefits from stock-based compensation Year Ended December 31, 2006 2005 2004 $ 1,247,779 $ 1,166,711 $ 1,087,946 (1,058,977) (1,003,264) (920,606) (46,981) (31,049) (16,072) 24,914 (1,385) — (31,334) (39,597) 15,768 — — (19,543) (33,637) 8,933 — Net cash provided by operating activities 118,229 108,284 123,093 Cash flows from investing activities: Capital expenditures, net Payments for acquisitions and long-term investments Proceeds from divestiture Payments for purchase of intangible assets (52,987) (46,071) 12,772 (36,055) (4,344) — — (5,000) (60,493) (58,983) 19,775 (10,000) Purchases of marketable securities and investments (334,047) (873,822) (2,257,694) Sales of marketable securities and investments 178,643 942,790 2,174,538 Foreign currency economic hedges, net Receipt (payment) of restricted cash Net cash used in investing activities Cash flows from financing activities: Net payments on notes payable Long-term borrowings Payments on long-term debt Debt issuance costs on 6.125% bonds Proceeds from issuance of common stock Excess tax benefits from stock-based compensation Net cash provided by financing activities (2,196) 36,138 6,397 (36,138) 6,539 — (207,748) (6,172) (186,318) (659) — (487) — 9,923 1,385 10,162 (6,847) (9,580) — 200,000 (447) (331) 8,915 — (1,781) (2,876) 7,464 — 1,290 193,227 Effect of exchange rate changes on cash 6,248 (2,420) 337 Net (decrease) increase in cash and cash equivalents (73,109) 100,982 130,339 Cash and cash equivalents at beginning of year Cash and cash equivalents at end of year 296,716 195,734 65,395 $ 223,607 $ 296,716 $ 195,734 Non-cash investing activities: Tender of Accent stock Receipt of Nanometrics stock $ $ (3,200) 5,354 $ $ — — $ $ — — The accompanying notes are an integral part of these consolidated financial statements. p25 Bio-Rad Laboratories | Annual Report 2006 Consolidated Statements of Changes in Stockholders’ Equity (in thousands) Common stock, $0.0001 par value: Balance at beginning of year Issuance of common stock Balance at end of year Additional paid-in capital: Balance at beginning of year Issuance of common stock Stock compensation expense Tax benefit from exercise of stock options Balance at end of year Retained earnings: Balance at beginning of year Net income Balance at end of year Accumulated other comprehensive income (loss): Balance at beginning of year Other comprehensive income (loss) Balance at end of year Year Ended December 31, 2006 2005 2004 $ 3 $ 3 $ — 3 — 3 60,112 9,923 5,363 2,832 78,230 49,628 8,916 — 1,568 60,112 3 — 3 42,164 6,250 — 1,214 49,628 570,807 489,254 421,012 103,263 81,553 68,242 674,070 570,807 489,254 27,052 40,183 67,235 58,003 (30,951) 27,052 32,628 25,375 58,003 Total stockholders’ equity $ 819,538 $ 657,974 $ 596,888 Comprehensive income, net of tax: Net income Currency translation adjustments Net unrealized holding gains net of tax of $5,767 $ 103,263 $ 81,553 $ 68,242 30,059 (30,535) 18,573 in 2006, $2,735 in 2005 and $3,870 in 2004 10,175 2,960 8,096 Reclassification adjustments for gains included in net income net of tax of $30 in 2006, $2,007 in 2005 and $623 in 2004 (51) (3,376) (1,294) Total comprehensive income $ 143,446 $ 50,602 $ 93,617 The accompanying notes are an integral part of these consolidated financial statements. p26 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements 1. SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation The consolidated financial statements include the accounts of Bio-Rad Laboratories, Inc. and all subsidiaries (referred to in this report as “Bio-Rad,” “we,” “us” and “our”) after elimination of intercompany balances and transactions. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates. Cash and Cash Equivalents Cash and cash equivalents consist of cash and highly liquid investments with original maturities of three months or less which are readily convertible into cash. Cash equivalents are stated at cost, which approximates fair market value. Restricted Cash Restricted cash of $36.1 million at December 31, 2005 represented deposits in a money market account that was used as collateral to protect a surety company in connection with its execution of a surety bond in the amount of $37.2 million to stay the enforcement of a judgment in a legal matter. This matter has since been settled and the surety bond is no longer needed. The cash is no longer restricted and has been returned to Cash and cash equivalents. Short-Term Investments Short-term investments consist of corporate, state and municipal securities with readily determinable fair market values and original maturities in excess of three months. Investments with maturities beyond one year may be classified as short-term based on their highly liquid nature and because such marketable securities represent the investment of cash that is available for current operations. Our investments are classified as “Available-for-sale” and accordingly are reported at fair value, with unrealized gains and losses, if material, reported as a component of stockholders’ equity, net of any related tax effect. Unrealized losses are charged against income when a decline in the fair market value of an individual security is determined to be other than temporary. Realized gains and losses on investments are included in investment income. Concentration of Credit Risk Financial instruments that potentially subject us to concentration of credit risk consist primarily of cash and cash equivalents, short-term investments and trade accounts receivable. Cash and cash equivalents and short-term invest- ments are placed with highly rated major financial institutions. We perform credit evaluation procedures related to our trade receivables and with the exception of certain developing countries, generally do not require collateral. As a result of increased risk in these developing countries, some Bio-Rad sales are subject to collateral letters of credit. Credit risk is generally limited due to the large number of customers and their dispersion across many geographic areas. However, a significant amount of trade receivables are with national healthcare systems in countries within the European Economic Community. We do not currently anticipate a credit risk associated with these receivables. p27 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) Allowance for Doubtful Accounts We maintain an allowance for doubtful accounts for estimated losses resulting from the inability of our customers to make required payments. The amount of the allowance is determined by analyzing known uncollectible accounts, aged receivables, economic conditions in the customers’ country or industry, historical losses and our customers’ credit-worthiness. Amounts later determined and specifically identified to be uncollectible are charged or written off against this reserve. This valuation allowance is reviewed quarterly to determine whether a change is warranted. Inventory Valuation Inventories are valued at the lower of actual cost or market and include material, labor and overhead costs. Management reviews the need for an inventory obsolescence reserve on a quarterly basis or, if warranted by circumstances, more frequently. In evaluating this reserve, technology changes, competition, customer demand and manufacturing quality are considered. Property, Plant and Equipment Property, plant and equipment are carried at historical cost. Included in property, plant and equipment is reagent rental equipment. We provide these instruments to our customers for use with our reagents. Property, plant and equipment are assessed for impairment annually or whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. Depreciation is computed on a straight-line basis over the estimated useful lives of the assets. Buildings and leasehold improvements are amortized over 15-30 years or the lives of the leases or improvements, whichever is shorter. With the exception of reagent rental equipment, which is amortized over a 1-5 year period, equipment is depreciated over 3-12 years. Net capital expenditures include proceeds from the sale of property, plant and equipment of $0.3 million, $3.2 million and $0.8 million for the years ended December 31, 2006, 2005 and 2004, respectively. Goodwill Goodwill, representing the excess of the cost over the net tangible and identifiable intangible assets of acquired businesses, is stated at cost. Goodwill is assessed for impairment by applying a fair-value based test annually or whenever events or changes in circumstances indicate that the carrying amount may not be recoverable (see Note 6). Income Taxes We account for income taxes under the asset and liability method which recognizes deferred tax assets and liabilities for the expected future tax consequences of temporary differences between carrying amounts and tax basis of assets and liabilities (see Note 8). Revenue Recognition Revenue is recognized when pervasive evidence of an arrangement exists, the price to the buyer is fixed and determinable, collectibility is reasonably assured and title has passed to the customer or product has been delivered absent specific contractual specifications. Equipment that requires factory installation is not recorded until installa- tion is complete and customer acceptance, if required contractually, has occurred. At the time the related revenue is p28 Bio-Rad Laboratories | Annual Report 2006 recognized, a provision is recognized for estimated product returns. Reagent agreements are a diagnostic industry sales method that provides use of an instrument if the customer exclusively purchases the company’s reagents to use on that instrument. We have evaluated the reagent agreements and account for the contracts under the terms of the guidance set forth in EITF 00-21, Accounting for Revenue Arrangements with Multiple Deliverables. All revenues that we earn under our reagent agreements are recognized when the reagent has been delivered to the customer. Service revenues on extended warranty contracts are recognized ratably over the life of the service agreement or as services are performed, if not under contract. Shipping and Handling We classify all freight billed to customers as net sales. Related freight costs are included in cost of goods sold. Warranty We warrant certain equipment against defects in design, materials and workmanship, generally for a period of one year. Upon shipment of that equipment, we establish, as part of cost of goods sold, a provision for the expected costs of such warranty based on historical experience, specific warranty terms and customer feedback. A review is performed on a quarterly basis to assess the adequacy of our warranty reserve. Components of the warranty accrual, included in Other current liabilities and Other long-term liabilities, were as follows (in millions): January 1 Provision for warranty Actual warranty costs December 31 Research and Development 2006 2005 $ 12.0 $ 10.1 14.9 (14.0) 13.3 (11.4) $ 12.9 $ 12.0 Internal research and development costs are expensed as incurred. Third-party research and development costs are expensed when the contracted work has been performed. Purchased in-process research and development costs are expensed at the time of purchase. Foreign Currency Balance sheet accounts of international subsidiaries are translated at the current exchange rate as of the end of the accounting period. Income statement items are translated at average exchange rates. The resulting translation adjustment is recorded as a separate component of stockholders’ equity. Foreign currency transaction gains and losses are included in Foreign exchange (gains) losses in the Consolidated Statements of Income. Transaction gains and losses result primarily from fluctuations in exchange rates when intercompany receivables and payables are denominated in currencies other than the functional currency of our subsidiary that recorded the transaction. p29 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) Forward Exchange Contracts As part of distributing our products, we regularly enter into intercompany transactions. We enter into forward foreign currency exchange contracts to manage foreign exchange risk of future movements in foreign exchange rates that affect foreign currency denominated intercompany receivables and payables. We do not use derivative financial instruments for speculative or trading purposes. In accordance with Statement of Financial Accounting Standards (SFAS) 133, Accounting for Derivative Instruments and Hedging Activities, we do not seek hedge accounting treatment for these contracts. As a result, these contracts, generally with maturity dates of 90 days or less and related primarily to currencies of industrial countries, are recorded at their fair value at each balance sheet date. The resulting gains or losses offset exchange gains or losses on the related receivables and payables, both of which are recorded as Foreign exchange (gains) losses in the Consolidated Statements of Income. The cash flows related to these contracts are classified as cash flows from investing activities in the Consolidated Statements of Cash Flows. Employee Stock Compensation Plans We maintain incentive and non-qualified stock option plans for officers and certain other key employees. We also have an employee stock purchase plan that provides that eligible employees may contribute toward the purchase of our Class A common stock. These plans are described more fully in Note 10. Prior to January 1, 2006, we applied Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to Employees (APB No. 25), and related interpretations, in accounting for our share-based compensation plans. All employee stock options were granted at or above the grant date market price. Accordingly, no compensation cost was recognized in the financial statements but was included as a pro forma disclosure in the consolidated financial statements. We also recorded no compensation expense in connection with our Employee Stock Purchase Plan (ESPP) as the purchase price of the stock was not less than 85% of the lower of the fair market value of our com- mon stock at the beginning of each offering period or at the end of each purchase period. As of January 1, 2006, we adopted the fair value recognition provisions of SFAS 123(R), Share-Based Payment using the modified prospective method. Under this transition method we are required to record compensation expense for all awards granted after the date of adoption and for the unvested portion of previously granted awards that remain outstanding at the date of adoption. In accordance with the modified prospective transition method, our results for prior periods have not been restated. See Note 10 for information on the impact of our adoption of SFAS 123(R). Earnings per Share Basic earnings per share is computed by dividing net income (loss) by the weighted average number of common shares outstanding for that period. Diluted earnings per share takes into account the effect of dilutive instruments, such as stock options, and uses the average share price for the period using the treasury stock method. Under the treasury stock method, the amount that the employee must pay for exercising stock options, the amount of compensation cost for future service that Bio-Rad has not yet recognized, and the amount of tax benefits that would be recorded in addi- tional paid-in capital when the award becomes deductible are assumed to be used to repurchase shares. Common stock equivalents are excluded from the diluted earnings per share calculation if the effect would be anti-dilutive. Weighted average shares used for diluted earnings per share include the dilutive effect of outstanding stock options to purchase 573,000, 599,000 and 765,000 shares for the years ended December 31, 2006, 2005 and 2004, respectively. Options to purchase 253,000, 281,000 and 10,000 shares of common stock were outstanding for the p30 Bio-Rad Laboratories | Annual Report 2006 years ended December 31, 2006, 2005 and 2004, respectively, but were excluded from the computation of diluted earnings per share because the price of the options was greater than the average market price of the common shares. Fair Value of Financial Instruments The estimated fair value of financial instruments has been determined using available market information or other appropriate valuation methodologies. Estimates are not necessarily indicative of the amounts that could be realized in a current market exchange as considerable judgment is required in interpreting market data used to develop esti- mates of fair value. The use of different market assumptions or estimation techniques could have a material effect on the estimated fair value. The estimated fair value of our financial instruments is as follows (in millions): Year Ended December 31, 2006 2005 Carrying Amount Fair Value Carrying Amount Fair Value Notes receivable and other assets Total long-term debt $ $ 103.6 426.1 $ $ 190.5 436.4 $ $ 82.4 426.1 $ $ 113.4 430.6 Financial instruments (e.g., notes receivable) that have fair values based on discounted cash flows, market quotations, and other appropriate valuation techniques are included in Other assets. Long-term debt has an estimated fair value based on quoted market prices for the same or similar issues. For certain financial instruments, including cash and cash equivalents, short-term investments, accounts receivable, marketable securities, notes payable, and accounts payable, the carrying amounts approximate fair value. New Financial Accounting Standards In September 2006, the Financial Accounting Standards Board (FASB) issued SFAS 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans. This new standard requires an employer to: (a) recognize in its statement of financial position an asset for a plan’s overfunded status or a liability for a plan’s underfunded status; (b) measure a plan’s assets and obligations that determine its funded status as of the end of the employer’s fiscal year; and (c) recognize changes in the funded status of a defined benefit postretirement plan in the year in which the changes occur. These changes are to be reported in comprehensive income of a business entity. The employer is required to recognize the funded status of a benefit plan and meet the disclosure requirements effective as of the end of fiscal years ending after December 15, 2006. The requirement to measure plan assets and benefit obligations as of the date of the employer’s fiscal year-end statement of financial position is effective for fiscal years ending after December 15, 2008. The adoption of SFAS 158 will not have a material effect on our consolidated results of operations and financial position. In September 2006, the Financial Accounting Standards Board (FASB) issued SFAS 157, Fair Value Measurements to eliminate the diversity in practice that exists due to different definitions of fair value and the limited guidance for applying those definitions in GAAP. SFAS 157 is effective for financial statements issued for fiscal years beginning after November 15, 2007. We are in the process of evaluating the impact of the adoption of SFAS 157 on the results of our operations and financial condition. p31 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) In June 2006, the FASB issued Interpretation No. 48, Accounting for Uncertainties in Income Taxes, an interpreta- tion of SFAS No. 109, Accounting For Income Taxes (FIN 48). FIN 48 prescribes a comprehensive model for how companies should recognize, measure, present, and disclose in their financial statements uncertain tax positions taken or expected to be taken on a tax return. Under FIN 48, tax positions must initially be recognized in the financial statements when it is more likely than not the position will be sustained upon examination by the tax authorities. Such tax positions must initially and subsequently be measured as the largest amount of tax benefit that is greater than 50% likely of being realized upon ultimate settlement with the tax authority assuming full knowledge of the position and relevant facts. FIN 48 is effective for fiscal years beginning after December 15, 2006. Bio-Rad will be required to apply the provisions of FIN 48 to all tax positions upon initial adoption on January 1, 2007, with any cumulative effect adjustment to be recognized as an adjustment to retained earnings. Additional FASB guidance on FIN 48 is pending. As a result, we are currently unable to finalize our estimate of the impact that adopting this Interpretation will have on our financial statements. Based on our analysis to date, however, we believe that the adoption of FIN 48 may result in recording an additional liability. 2. ACQUISITIONS In November 2006, we acquired Ciphergen Biosystems, Inc.’s ProteinChip® Systems business and worldwide rights to its Surface Enhanced Laser Desorption/Ionization (SELDI) technology for approximately $18 million in cash. The acquisition includes certain product lines, manufacturing capability, and intellectual property as well as access to Ciphergen’s life science customer base. Under the terms of the agreement, Ciphergen will retain rights to the diagnostics market. Through a separate supply agreement, Bio-Rad will supply instruments and reagents to Ciphergen to support their diagnostics business. The total purchase of $18.0 million included $5.4 million of net tangible assets, $1.0 million of goodwill and $11.6 million of intangible assets. The SELDI patent is presently under review by the U.S. Patent and Trademark Office. If the patent is granted, we will pay an additional $2.0 million to Ciphergen. All goodwill will be deductible for tax purposes. Purchased in-process research and development of $3.8 million was charged to expense in the fourth quarter of 2006. The allocation of the total purchase price to net tangible assets, goodwill and other intangible assets has been recorded at their fair market value based upon management estimates and third party valuations. The results of this acquisition are included in our consolidated financial statements from the acquisition date, in our Life Science segment. We also made a $3.0 million equity investment in Ciphergen as part of the transaction. In October 2006, we completed the acquisition of Blackhawk BioSystems, Inc. for approximately $16.7 million in cash. With the acquisition of the Blackhawk infectious disease controls, we will be able to offer a broader line of quality control products for the clinical laboratory. Bio-Rad acquired $2.2 million of net tangible liabilities, $5.3 million of goodwill and $13.6 million of intangible assets. All goodwill will not be deductible for tax purposes. Purchased in-process research and development of $0.3 million was charged to expense in the fourth quarter of 2006. The allocation of the total purchase price to net tangible liabilities, goodwill and other intangible assets has been recorded at their fair market value based upon management estimates and third party valuations. The results of Blackhawk are included in our consolidated financial statements from the acquisition date, in our Clinical Diagnostics segment. Pro forma results of operations for our business acquisitions have not been presented because the effects were not material to the consolidated financial statements on either an individual or aggregate basis. p32 Bio-Rad Laboratories | Annual Report 2006 3. SHORT-TERM INVESTMENTS Short-term investments consist of the following (in millions): Available-for-sale securities: Corporate obligations Asset backed securities U.S. Agencies Mortgage backed securities Marketable equity securities Variable rate notes Auction rate securities Certificates of deposit Total short-term investments December 31, 2006 2005 $ 143.7 $ 31.4 43.5 32.5 15.4 14.4 10.0 — 5.0 36.6 25.5 10.2 — 8.7 3.9 — $ 264.5 $ 116.3 Management classifies investments in marketable securities at the time of purchase and reevaluates such classifica- tion at each balance sheet date. Securities classified as Available-for-sale are stated at fair value which approximates cost. As of December 31, 2006, the short-term investments will mature within one year. 4. INVESTMENTS We own shares of ordinary voting stock of Sartorius AG, of Goettingen, Germany, a process technology supplier to the biotechnology, pharmaceutical, chemical and food and beverage industries. We purchased shares in 2006 and 2005 for approximately $6 and $4 million, respectively, bringing our total investment to approximately 27% of the outstanding voting shares of Sartorius at December 31, 2006. The Sartorius family trust and Sartorius family members hold a controlling interest of the outstanding voting shares. We do not have any representative or designee on Sartorius’ board of directors, nor do we have any other influence over the operating and financial policies of Sartorius. Therefore, we account for this investment using the cost method. This investment is reported in Other assets. In December 1997, we began investing in Instrumentation Laboratory, S.p.A. (IL), an Italian based clinical diag- nostics company. A privately held company based in Spain controls the majority of the outstanding stock of IL. As of December 31, 2004, we valued our investment in IL at $4.0 million which reflects a $2.4 million write-down recorded in Other income, net. In October 2005, Bio-Rad entered into an agreement to sell all its shares back to IL. We received cash of $12.0 million and recorded in Other income, net, a pre-tax gain of $7.9 million (see Note 11). During July 2006, Accent Semiconductor Technology Inc. (Accent), a private company, was acquired by Nanometrics Inc. (Nanometrics), a publicly held company. In preparation for the merger, Accent repaid the $11.8 million note receivable and accrued interest owed to Bio-Rad as part of Accent’s 2000 purchase of the assets and certain liabilities of our former semiconductor and optoelectronic metrology business. As part of the merger agreement, we tendered our ownership interest in Accent in exchange for approximately 600,000 shares of Nanometrics stock valued at $5.4 million on conversion. We also received a $2.5 million facilitation fee for aiding in the merger. These transactions p33 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) resulted in a gain of $4.7 million included in Other (income) expense, net (see Note 11). Our current ownership interest in Nanometrics is less than 5%, is marked to market and is included in Other assets. There are certain restrictions on selling our Nanometrics shares within the first year of ownership. On July 26, 2005, BioSource International, Inc. (BioSource) announced in a press release that it had entered into a definitive merger agreement under which Invitrogen Corporation would acquire BioSource for $12.50 per share in cash. In October 2005, we tendered our shares of BioSource to Invitrogen Corporation for $12.50 per share in cash and received cash of $8.3 million. We recorded in Other income, net, a pre-tax gain of $3.3 million (see Note 11). 5. DISCONTINUED OPERATIONS On May 31, 2004, we sold a group of assets and transferred certain liabilities that comprise a substantial portion of our confocal microscopy product line to Carl Zeiss Jena GmbH. Proceeds of $19.8 million were offset by net assets of $5.7 million, lease settlements of $6.7 million and severance, legal and other costs of $1.7 million resulting in a pre-tax gain of $5.7 million. As required by SFAS 144, Accounting for the Impairment or Disposal of Long-Lived Assets, with the disposition of this asset group, the sales and expenses related to this product line for current and prior periods have been reclassified as a separate line on the income statement titled “Discontinued Operations.” During 2005, Bio-Rad reached an agreement to settle the $6.7 million lease commitment and revised our lease settlement estimate to $2.7 million to exit the facility in 2005. Consequently, we recognized a $4.0 million gain on the revised disposition. There were no sales or pre-tax operating losses attributable to the discontinued operations for the years ended December 31, 2006 and 2005. The discontinued operations generated net sales of $6.3 million and a pre-tax operating loss of $2.0 million for the year ended December 31, 2004. 6. GOODWILL AND OTHER PURCHASED INTANGIBLE ASSETS As part of the acquisition of Ciphergen Biosystems, Inc. in December 2006 (see Note 2), we added $1.0 million of goodwill and $7.8 million of intangible assets: $7.2 million of developed technology and $0.6 million in customer lists. The intangibles are recorded in our Life Science segment. As part of the acquisition of Blackhawk BioSystems, Inc. in October 2006 (see Note 2), we added $5.3 million of goodwill and $13.3 million of intangible assets: $11.5 million of developed technology, $0.4 million of covenants not to compete, $0.2 million of customer lists, and $1.2 million of other intangibles. These intangibles are part of our Clinical Diagnostics segment. In March 2005, we purchased the rights to certain patents for $1.0 million. In June 2004, we purchased $14.0 mil- lion of intangible assets related to licensing agreements. We paid $6.0 million upon acquisition and $4.0 million in the third quarter of 2004. The remaining $4.0 million was paid in 2005. These intangibles are part of our Clinical Diagnostics segment. p34 Bio-Rad Laboratories | Annual Report 2006 During the fourth quarter of 2005, $19.8 million of impairment losses related to intangible and long-lived assets were recorded in the Life Science segment. Of these losses, $15.8 million related to intangible and tangible assets acquired from MJ GeneWorks (MJ). The circumstance leading to the impairment was the November 10, 2005 recommended ruling of the Connecticut Federal District Court that it would not enforce the August 30, 2005 settlement between Bio-Rad, Applera and Roche (see Note 14). As a result of this decision Bio-Rad continued to be barred from selling, servicing or marketing MJ thermal cyclers and real time polymerase chain reaction (PCR) equipment in the United States. The asset group impaired included fixed assets at the Massachusetts manufactur- ing location making the MJ cyclers along with intangible assets related to developed technology, U.S. customer mailing lists, trade names and non-compete agreements. The determination of fair value was calculated converting estimated future cash flows to their present value, using the rate of return expected by an investor for an investment with similar perceived risk. Additionally, $4.0 million of intangible and tangible assets related to our microarray product line manufactured in Waterloo, Canada were impaired. In the fourth quarter, we decided to close the plant and no longer manufacture the products that related to the specific patents purchased from Virtek in 2002. We have developed new microarray products that do not use the technology covered in the patents. The discontinued products covered by the patents will have negligible sales and cash flow in 2007 and beyond. Goodwill balances have been included in corporate for segment reporting purposes in Note 15. Other than goodwill, we have no intangible assets with indefinite lives. Information regarding our identifiable purchased intangible assets is as follows (in millions): December 31, 2006 Average Useful Life (years) Carrying Amount Accumulated Amortization Net Developed Product Technology 2-15 $ 27.9 $ Licenses Know How Covenants Not to Compete Patents Customer Lists Other 13 1-4 2-5 4 2-15 5-15 14.0 9.8 2.4 1.0 1.4 1.3 3.6 2.2 5.7 1.1 0.1 0.4 0.1 $ 24.3 11.8 4.1 1.3 0.9 1.0 1.2 $ 57.8 $ 13.2 $ 44.6 p35 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) December 31, 2005 Average Useful Life (years) Carrying Amount Accumulated Amortization Net Developed Product Technology Licenses Know How Covenants Not to Compete Patents Customer Lists Other 3-6 14 1-5 3 4 3 1-6 $ 9.2 $ 14.0 8.7 2.0 1.0 0.6 2.2 $ 37.7 $ 1.4 1.3 3.7 0.7 0.2 2.0 9.3 — $ 7.8 12.7 5.0 1.3 1.0 0.4 0.2 $ 28.4 Recorded purchased intangible asset amortization expense for the years ended December 31, 2006, 2005, and 2004 was $5.3 million, $11.0 million and $6.9 million, respectively. Estimated purchased intangible asset amortization expense (based on existing intangible assets) for the years ended December 31, 2007, 2008, 2009, 2010 and 2011 is $6.9 million, $6.3 million, $4.8 million, $3.6 million and $2.9 million, respectively. 7. NOTES PAYABLE AND LONG-TERM DEBT Notes payable include local credit lines maintained by our subsidiaries aggregating approximately $33.5 million, of which $30.1 million was unused at December 31, 2006. At December 31, 2005, these lines aggregated approxi- mately $34.1 million, of which $30.8 million was unused. The weighted average interest rate on these lines was 4.5% and 8.3% at December 31, 2006 and 2005, respectively. Bio-Rad Laboratories, Inc. guarantees most of these credit lines. In June 2005, Bio-Rad entered into a new Credit Agreement, which amends and restates the Credit Agreement dated September 9, 2003, as amended December 8, 2004. Borrowings are permitted up to a maximum of $150.0 million on a revolving basis and can be used to make acquisitions, for working capital and for other general corporate purposes. Borrowings under this line of credit carry a floating rate of interest based on a reference rate dictated by the type of borrowing plus the applicable margin. Under certain conditions, the Credit Agreement may be increased up to an additional $50 million. The credit agreement will mature on June 21, 2010. The Credit Agreement is secured by substantially all of our personal property assets, the assets of our domestic subsidiar- ies and 65% of the capital stock of certain foreign subsidiaries. It is guaranteed by all of our existing and future domestic subsidiaries (other than immaterial domestic subsidiaries as defined for purposes of the Credit Agreement). p36 Bio-Rad Laboratories | Annual Report 2006 The principal components of Long-term debt are as follows (in millions): 7.5% Senior Subordinated Notes 6.125% Senior Subordinated Notes Capitalized leases Less current maturities Long-term debt December 31, 2006 2005 $ 225 .0 $ 225.0 200.0 1.1 426.1 (0.5) 200.0 1.1 426.1 (0.4) $ 425.6 $ 425.7 In December 2004, Bio-Rad sold $200.0 million principal amount of Senior Subordinated Notes due 2014 (6.125% Notes). The notes pay a fixed rate of interest of 6.125% per year. Upon any sale of our common stock, we have the right to repurchase up to 35% of the 6.125% Notes any time prior to December 15, 2007 at a specified redemption price plus accrued and unpaid interest and certain other charges. Furthermore, we have the option to redeem any or all of the 6.125% Notes at various declining redemption prices or at 100% of the principal amount plus the “appli- cable premium” (as defined by the indenture) along with accrued and unpaid interest and certain other charges depending on the date redeemed. Bio-Rad’s obligations under the 6.125% Notes are not secured, rank equal to other senior subordinated notes and rank junior to all Bio-Rad’s existing and future senior debt. In August 2003, Bio-Rad sold $225.0 million principal amount of Senior Subordinated Notes due 2013 (7.5% Notes). The notes pay a fixed rate of interest of 7.5% per year. We have the option to redeem any or all of the 7.5% Notes at various declining redemption prices or at 100% of the principal amount plus the “applicable pre- mium” (as defined by the indenture) along with accrued and unpaid interest and certain other charges depending on the date redeemed. Bio-Rad’s obligations under the 7.5% Notes are not secured, rank equal to other senior subordinated notes and rank junior to all Bio-Rad’s existing and future senior debt. The Credit Agreement, the 6.125% Notes, and the 7.5% Notes require Bio-Rad to comply with certain financial ratios and covenants, among other things. The covenants include a leverage ratio test, an interest coverage test and a consolidated net worth test. There are also restrictions on our ability to declare or pay dividends, incur debt, guarantee debt, enter into transactions with affiliates, merge or consolidate, sell assets, make investments, create liens and prepay subordinated debt. We were in compliance with all financial ratios as of December 31, 2006 and 2005. Maturities of long-term debt at December 31, 2006 are as follows: 2007 – $0.5 million; 2008 – $0.4 million; 2009 – $0.1 million; 2010 – $0.1 million; 2011 – $0.0 million; thereafter – $425.0 million. p37 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) 8. INCOME TAXES The U.S. and international components of income before taxes are as follows (in millions): U.S. International Income from continuing operations before taxes The provision (benefit) for income taxes consists of (in millions): Current: U.S. International Deferred: U.S. International Provision for income taxes Year Ended December 31, 2006 2005 2004 $ 66.8 $ 35.0 $ 3.5 75.2 58.4 93.8 $ 142.0 $ 93.4 $ 97.3 Year Ended December 31, 2006 2005 2004 $ 13.2 $ 11.6 $ (2.4) 24.6 37.8 22.6 34.2 36.4 34.0 $ 0.8 0.2 1.0 $ (13.6) $ (5.1) (4.8) (18.4) 2.1 (3.0) $ 38.8 $ 15.8 $ 31.0 Bio-Rad’s income tax provision differs from the amount computed by applying the U.S. federal statutory rate to income before taxes as follows: U. S. statutory tax rate State taxes, net of federal benefit Foreign income at other than U.S. tax rates Foreign losses not benefited Non-taxable dividend income Export sales benefit Tax credits Capital losses not benefited/(benefited) Increase (decrease) in tax reserves Other Provision for income taxes p38 Year Ended December 31, 2006 2005 2004 35 % 35 % 35 % 1 (1) 1 (3) (2) (2) — 1 (3) — (7) 3 (6) (3) (2) (5) 3 (1) 2 (1) 3 (2) (2) (2) 1 (1) (1) 27 % 17 % 32 % Bio-Rad Laboratories | Annual Report 2006 Deferred income taxes reflect the net tax effect of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of deferred tax assets and liabilities are as follows (in millions): Deferred tax assets Bad debt reserve Inventory reserve Warranty reserve Vacation pay reserve Net operating loss Royalty reserve Retirement reserve Depreciation In-process R&D, goodwill and acquired intangible assets State tax credit carryforward Miscellaneous — other items Valuation allowance Deferred tax liabilities Unrealized holding gains Deferred gain Development cost of Hercules facility Foreign exchange gain/loss Depreciation Goodwill and acquired intangible assets Miscellaneous — other items Year Ended December 31, 2006 2005 $ 4.2 $ 3.2 13.2 6.1 6.3 16.2 — 3.8 6.2 16.5 7.2 15.3 (26.5) 68.5 10.6 5.2 0.8 2.3 1.9 9.4 3.3 12.2 5.5 6.0 10.1 4.4 3.6 5.5 15.3 6.4 12.0 (17.7) 66.5 4.8 5.2 1.2 2.3 5.6 2.0 2.8 $ 33.5 $ 23.9 At December 31, 2006, Bio-Rad’s international subsidiaries had combined net operating loss carryforwards of $39.4 million. These loss carryforwards have no expiration date. The utilization of these carryforwards is limited to the separate taxable income of each individual subsidiary. At December 31, 2006, Bio-Rad had an unutilized domestic net operating loss carryforward of $11.7 million. The loss carryforward will expire in the year 2018. The utilization of the loss carryforward is limited to Bio-Rad’s domestic taxable income. At December 31, 2006, Bio-Rad had a California tax credit carryforward of $7.2 million. The credit carryforward has no expiration date. The utilization of the tax credit carryforward is limited to the extent Bio-Rad has California taxable income. p39 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) A valuation allowance is needed to reduce the deferred tax assets to an amount that is more likely than not to be realized. The net change in the valuation allowance in 2006 was an increase of $8.8 million, primarily relating to net operating losses acquired or incurred and credit carryforwards in jurisdictions with no future projected earnings. Bio-Rad does not provide taxes which would be payable if the cumulative undistributed earnings of its international subsidiaries, approximately $314 million at December 31, 2006, were remitted to the U.S. parent company. Unless it becomes advantageous to remit earnings for tax reasons, foreign exchange reasons, or to fulfill working capital or investment requirements, such earnings are indefinitely reinvested in its operations. If these earnings were repatriated to the United States, they would generate foreign tax credits that would reduce the U.S. federal tax liability associated with the distribution. The potential deferred tax liability for these earnings would be approximately $50 million. 9. STOCKHOLDERS’ EQUITY Bio-Rad’s outstanding stock consists of Class A Common Stock (Class A) and Class B Common Stock (Class B). Each share of Class A and Class B participates equally in the earnings of Bio-Rad, and is identical in most respects except that Class A has limited voting rights. Each share of Class A is entitled to one-tenth of a vote on most mat- ters, and each share of Class B is entitled to one vote. Additionally, Class A stockholders are entitled to elect 25% of the Board of Directors and Class B stockholders are entitled to elect the balance of the directors. Cash dividends may be paid on Class A shares without paying a cash dividend on Class B shares but no cash dividend may be paid on Class B shares unless at least an equal cash dividend is paid on Class A shares. Class B shares are convertible at any time into Class A shares on a one-for-one basis at the option of the stockholder. 10. STOCK OPTION AND PURCHASE PLANS Description of Share-Based Compensation Plans Stock Option Plans We have two stock option plans for officers and certain other employees: the Amended 1994 Stock Option Plan (the “1994 Plan”) and the 2003 Stock Option Plan (the “2003 Plan”). Both plans authorize the grant to employees of incentive stock options and non-qualified stock options. The maximum number of shares issuable under the 2003 Plan is 1,675,000 shares and may be of either Class A or Class B Common Stock. Of these shares, 823,090 remain available to be granted as of December 31, 2006. We no longer make stock option grants under the 1994 Plan. Under both of these plans, Class A and Class B options are granted at prices not less than fair market value on the date of grant. Generally, options granted have a term of 10 years and vest in increments of 20% per year over a five-year period on the yearly anniversary date of the grant. For options granted before January 1, 2001, options vest in increments of 25% over a four-year period on the yearly anniversary date of the grant. p40 Bio-Rad Laboratories | Annual Report 2006 Employee Stock Purchase Plan (ESPP) Bio-Rad has an employee stock purchase plan that provides that eligible employees may contribute up to 10% of their compensation up to $25,000 annually toward the quarterly purchase of our Class A common stock. The employees purchase price is 85% of the lesser of the fair market value of the stock on the first business day or the last business day of each calendar quarter. Bio-Rad has authorized the sale of 2,390,000 shares of common stock under the ESPP. Stock Options The following table summarizes stock option activity (amounts reported in the Price columns represent the weighted average exercise price): Year Ended December 31, 2006 2005 2004 Shares Price Price Price Shares Shares Shares Price Price Price Shares Shares Shares Shares Shares Price Price Price Price Price Price Price Outstanding at beginning of year 1,589,206 $ 34.43 1,630,717 $ 27.14 1,582,915 $ 20.04 Granted Exercised 313,233 62.68 307,822 57.25 306,990 (177,867) 25.81 (299,485) 16.26 (221,759) Forfeited/Expired (56,803) 51.79 (49,848) 46.05 (37,429) 53.82 14.02 23.58 Outstanding at end of year 1,667,769 $ 40.06 1,589,206 $ 34.43 1, 630,717 $ 27.14 Options exercisable at year-end 815,318 $ 25.65 746,765 $ 20.50 849,633 $ 15.22 Weighted average fair value of options granted during the year $ 29.85 $ 20.76 $ 18.74 p41 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) The following summarizes information about stock options outstanding at December 31, 2006: Options Outstanding Options Exercisable Number Outstanding at 12/31/06 Weighted Average Remaining Contractual Life (in years) Weighted Average Exercise Price Number Exercisable at 12/31/06 Weighted Average Exercise Price 282,977 269,614 283,585 253,407 269,954 308,232 3.42 2.87 5.51 6.94 8.10 9.00 $ 11.34 $ 21.38 $ 34.06 $ 53.09 $ 57.13 $ 62.62 282,977 224,005 169,710 89,629 48,865 132 $ 11.34 $ 19.91 $ 33.52 $ 53.03 $ 57.09 $ 58.85 Range of Exercise Prices $10.75-$11.94 $11.97-$28.61 $28.88-$36.00 $36.50-$53.75 $56.05-$57.49 $58.85-$69.30 The weighted average remaining contractual term for stock options outstanding and exercisable was 6.01 years and 4.22 years, respectively, as of December 31, 2006. The aggregate intrinsic value for stock options outstanding and exercisable was $70.8 million and $46.4 million, respectively, as of December 31, 2006. The total intrinsic value of stock options exercised during the year ended December 31, 2006 was approximately $8 million. Intrinsic value for stock options is defined as the difference between the current market value and the grant price. Cash received from stock options exercised during the year ended December 31, 2006 was $4.6 million. The actual tax benefit realized for the tax deductions from stock options exercised totaled $1.8 million in 2006. As of December 31, 2006, there was $9.8 million of total unrecognized compensation cost from stock options. That cost is expected to be recognized over a weighted-average period of approximately two years. We currently use the Black-Scholes option-pricing model to calculate the fair value of share-based awards. This model incorporates various assumptions including volatility, interest rate and expected life. The following table summarizes the assumptions used to compute the weighted average fair value of stock option grants. Expected volatility Risk-free interest rate Expected life (in years) Expected dividend Year Ended December 31, 2006 2005 2004 36 % 4.62 % 7.4 — 37 % 3.45 % 4.7 — 39 % 2.73 % 4.3 — Volatility was based on the historical volatilities of our common stock for a period equal to the stock option’s expected life. The risk-free interest rate is based on the U.S. Treasury yield curve in effect at the time of the grant. In 2005, the expected life was estimated using the historical exercise behavior of employees. In 2006, we estimated the expected life using the simplified method described in the SEC’s Staff Accounting Bulletin No. 107. We do not anticipate paying any cash dividends in the future and therefore use an expected dividend yield of zero. p42 Bio-Rad Laboratories | Annual Report 2006 Employee Stock Purchase Plan The fair value of the employee’s purchase rights was estimated using the Black-Scholes option-pricing model with the following weighted average assumptions. Expected volatility Risk-free interest rate Expected life (in years) Expected dividend Weighted average fair value of purchase rights Year Ended December 31, 2006 2005 2004 28 % 4.66 % .25 — 29 % 2.95 % .25 — 21 % 1.22 % .25 — $ 13.68 $ 11.38 $ 10.81 The major assumptions are primarily based on historical data. Volatility was based on the historical volatilities of our common stock for a period equal to the purchase right’s expected life. The risk-free interest rate is based on the U.S. Treasury yield curve in effect at the time of the grant. We do not anticipate paying any cash dividends in the future and therefore use an expected dividend yield of zero. We sold 99,888 shares for $5.3 million, 92,869 shares for $4.0 million and 68,932 shares for $3.1 million under the ESPP to employees in 2006, 2005 and 2004, respectively. At December 31, 2006, 507,550 shares remain authorized under the ESPP. We currently issue new shares to satisfy stock option exercises and ESPP stock purchases, but may use repurchased stock to fulfill our obligations. Impact of Adoption of SFAS 123(R) For the year ended December 31, 2006, we recognized pre-tax share-based compensation expense of $5.4 million and after-tax share based compensation expense of $4.6 million. After-tax share-based compensation expense reduced each of our net income per share and diluted net income per share by $0.17, for the year ended December 31, 2006. Included in our share-based compensation expense is the cost related to prior year option grants that vest after January 1, 2006 and the cost related to our ESPP stock purchases. Prior to the adoption of SFAS 123(R), we presented all benefits of tax deductions resulting from the exercise of share-based compensation as operating cash flows in the Consolidated Statements of Cash Flows. SFAS 123(R) requires the benefits of tax deductions in excess of the compensation cost recognized for those options (excess tax benefits) to be classified as financing cash flows. The recognized tax benefit was $1.4 million for the year ended December 31, 2006. For options granted before January 1, 2006, we amortized the fair value on an accelerated basis. For options granted after January 1, 2006, we amortized the fair value on a straight-line basis. All options are amortized over the requisite service periods of the awards, which are generally the vesting periods. p43 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) In accordance with SFAS 123(R), we recognize share-based compensation net of estimated forfeitures. Prior to January 1, 2006, we recognized forfeitures and the corresponding reduction in pro forma expenses as they occurred. Pro forma Information Under SFAS 123 for Years Prior to 2006 The following table illustrates the effect on net income and earnings per share if we had applied the fair value recognition provisions of SFAS 123 in accounting for the compensation cost for our stock option and stock purchase plans (in millions, except per share data). Net income, as reported Deduct: Total stock based employee compensation expense determined under fair value methods for all awards net of related tax effects Pro forma net income Earnings per share: Basic — as reported Basic — pro forma Diluted — as reported Diluted — pro forma 11. OTHER INCOME AND EXPENSE Other income, net includes the following income (expense) components (in millions): Year Ended December 31, 2005 2004 $ 81.6 $ 68.2 3.4 3.0 $ 78.2 $ 65.2 $ 3.13 $ 3.00 $ 3.06 $ 2.93 $ 2.65 $ 2.54 $ 2.58 $ 2.47 Interest and investment income Income from equity investee Write-down of investments (Note 4) Litigation settlement (Note 14) Gains on sales of investments (Note 4) Miscellaneous other items Other income, net Year Ended December 31, 2006 2005 2004 $ 22.3 $ 16.7 $ — — — 4.7 2.0 0.1 — (1.2) 11.2 2.2 6.6 3.1 (2.4) 1.9 — 1.9 $ 29.0 $ 29.0 $ 11.1 p44 Bio-Rad Laboratories | Annual Report 2006 12. SUPPLEMENTAL CASH FLOW INFORMATION The reconciliation of net income to net cash provided by operating activities is as follows (in millions): Net Income $ 103.3 $ 81.6 $ 68.2 Year Ended December 31, 2006 2005 2004 Adjustments to reconcile income to net cash provided by operating activities (net of effects of acquisitions): Depreciation Amortization Excess tax benefits from stock compensation Stock-based compensation Foreign currency economic hedge transactions, net Gains on dispositions of securities Increase in accounts receivable, net Increase in inventories, net Decrease (increase) in other current assets Increase in accounts payable and other current liabilities Increase (decrease) in income taxes payable Increase (decrease) in deferred taxes Write-down of investments Impairment losses on long-lived assets Litigation settlement related to MJ acquisition Other 48.7 6.7 (1.4) 5.4 2.2 (0.1) (25.5) (22.8) 16.9 17.3 3.8 1.2 — — (47.0) 9.5 49.1 11.9 — — (6.4) (13.3) (7.7) (18.7) (12.1) 20.5 1.6 (15.0) — 19.8 — (3.0) 46.2 9.3 — — (6.5) (1.9) (4.4) (5.5) 3.5 1.1 (2.8) 2.5 2.4 — — 11.0 Net cash provided by operating activities $ 118.2 $ 108.3 $ 123.1 13. COMMITMENTS AND CONTINGENT LIABILITIES Rents and Leases Net rental expense under operating leases was $26.7 million in 2006, $23.7 million in 2005 and $23.0 million in 2004. Leases are principally for facilities and automobiles. Annual future minimum lease payments at December 31, 2006 under operating leases are as follows: 2007 – $27.7 million; 2008 – $19.3 million; 2009 – $12.1 million; 2010 – $8.8 million; 2011 – $7.1 million; subsequent to 2011 – $9.9 million. Deferred Profit Sharing Retirement Plan We have a profit sharing plan covering substantially all U.S. employees. Contributions are made at the discretion of the Board of Directors. Bio-Rad has no liability other than for the current year’s contribution. Contributions charged to income were $7.8 million, $7.5 million and $7.0 million in 2006, 2005 and 2004, respectively. p45 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) Other Post-Employment Benefits In several foreign locations we are statutorily required to provide a lump sum severance or termination indemnity to our employees. Under these plans, the vested benefit obligation at December 31, 2006 and 2005 was $17.4 million and $15.4 million, respectively and has been included in Other long-term liabilities in the consolidated balance sheets. These plans are not required to be funded, and as such, there is no trust or other device used to accumulate assets to settle these obligations. Foreign Exchange Contracts We enter into forward foreign exchange contracts as an economic hedge against foreign currency denominated intercompany receivables and payables. At December 31, 2006, we had contracts maturing in January through March 2007 to sell foreign currency with a nominal value of $48.1 million and an unrealized gain of $0.2 million. Contracts to purchase foreign currency had a nominal value of $19.2 million with a negligible unrealized loss. Insurance We carry a deductible for workers’ compensation and a portion of our group health insurance cost. Accruals for losses are based on our claims experience and actuarial assumptions followed in the insurance industry. Should a greater amount of claims occur compared to our estimates or cost of medical care increase beyond what has been anticipated, reserves recorded may not be sufficient and additional charges to income may be required. Letters of Credit In the ordinary course of business, we are at times required to post letters of credit. The letters of credit are issued by our banks to guarantee our obligations to insurance companies. We were contingently liable for $5.3 million of standby letters of credit with banks as of December 31, 2006. Taxes Settlement of open tax years, as well as tax issues in other countries where we conduct our business, are not expected to have a material effect on the consolidated financial position or liquidity of Bio-Rad and, in the opinion of management, adequate provision has been made for income and franchise taxes for all years under examination or subject to future examination. 14. LEGAL PROCEEDINGS On February 9, 2006, Bio-Rad completed negotiations with Applera Corporation (Applera) and Roche Molecular Systems, Inc. to settle the patent infringement litigation against MJ Research, Inc. (MJ Research) which Bio-Rad acquired in 2004. The total net settlement amount, including amounts related to previously accrued back royalties, was approximately $62 million. We recognized $1.2 million of additional expense in the fourth quarter of 2005 to adjust our estimated liability as a result of the settlements. In connection with the settlements, we entered into a royalty-bearing license agreement with Applera relating to our real-time instrument business in the United States and a term limited license in the rest of the world. Applera filed an action in the Regional Court of Düsseldorf, Germany in February 2003 against Bio-Rad alleg- ing infringement of a European patent relating to real-time PCR thermal cycler technology. MJ Research is also a defendant in this action. The suit seeks actual damages, costs and expenses and injunctive relief. In May 2004, the Düsseldorf court issued an adverse ruling against MJ Research and us, which included an injunction against p46 Bio-Rad Laboratories | Annual Report 2006 us and MJ Research from selling any real-time PCR instruments and reagents in Germany. In December 2004, the European Patent Office revoked the patent for lack of novelty and the injunctions against MJ Research and Bio-Rad were lifted, allowing MJ Research and us to resume sales of real-time PCR thermal cyclers and reagents. Applera appealed revocation of the patent, and in July 2006 the European Patent Office reversed its novelty rejection and reinstated the patent, subject to further review by the Opposition Division of the European Patent Office for other grounds for revocation. The patent will be returned to the Opposition Division for review of these other issues. We are party to various claims, legal actions and complaints arising in the ordinary course of business. We do not believe that any ultimate liability resulting from any of these lawsuits will have a material adverse effect on our results of operations, financial position or liquidity. However, we cannot give any assurance regarding the ultimate outcome of these lawsuits and their resolution could be material to our operating results for any particular period, depending upon the level of income for the period. 15. SEGMENT INFORMATION Bio-Rad is a multinational manufacturer and worldwide distributor of its own life science research products and clinical diagnostics products. We have two reportable segments: Life Science and Clinical Diagnostics. These reportable segments are strategic business lines that offer different products and services and require different marketing strategies. The Life Science segment develops, manufactures, sells and services reagents, apparatus and instruments used for biological research. These products are sold to university and medical school laboratories, pharmaceutical and biotechnology companies, food testing laboratories and government and industrial research facilities. The Clinical Diagnostics segment develops, manufactures, sells and services automated test systems, informatics systems, test kits and specialized quality controls for the healthcare market. These products are sold to reference laboratories, hospital laboratories, state newborn screening facilities, physicians’ office laboratories, transfusion laboratories, and insurance and forensic testing laboratories. The remainder of our former Analytical Instruments segment is included in Other Operations. The material product lines of this segment were sold in 2001 and 2000. The accounting policies of the segments are the same as those described in Significant Accounting Policies (see Note 1). Segment profit or loss used for corporate management purposes includes an allocation of corporate expense based upon sales and an allocation of interest expense based upon accounts receivable and inventories. Segments are expected to manage only assets completely under their control. Accordingly, segment assets include primarily accounts receivable, inventories and gross machinery and equipment. Goodwill balances have been included in corporate for segment reporting purposes. p47 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) Information regarding industry segments at December 31, 2006, 2005 and 2004 and for the years then ended is as Life Science Clinical Diagnostics Other Operations $ 575.6 $ 684.9 $ 13.4 549.9 504.7 618.4 576.4 12.6 $ 13.0 $ 18.8 $ 13.8 8.0 18.7 12.1 $ 18.0 $ 33.8 $ 24.6 18.8 $ 25.7 (0.5) 31.4 33.0 32.6 $89.6 64.4 60.1 8.9 0.2 0.1 0.1 0.3 0.1 0.2 $0.6 (0.6) (0.1) $ 318.5 $ 458.8 $ 276.3 277.5 392.9 401.2 $ 10.3 $ 34.7 $ 11.9 24.1 25.1 34.6 7.8 5.4 6.0 0.3 0.1 0.1 follows (in millions): Segment net sales Allocated interest expense Depreciation and amortization Segment profit (loss) Segment assets Capital expenditures 2006 2005 2004 2006 2005 2004 2006 2005 2004 2006 2005 2004 2006 2005 2004 2006 2005 2004 p48 Bio-Rad Laboratories | Annual Report 2006 The Life Science segment profit (loss) for 2006 includes $3.8 million of in-process research and development expense purchased in the Ciphergen acquisition and 2005 includes $19.8 million of impairment losses on long-lived assets (see Note 6). The Life Science segment profit (loss) for 2004 includes $13.7 million of in-process research and development expense purchased as part of the MJ GeneWorks, Inc. acquisition. The difference between total segment allocated interest expense, depreciation and amortization, and capital expenditures and the corresponding consolidated amounts is attributable to our corporate headquarters. The following reconciles total segment profit to consolidated income before taxes (in millions): Total segment profit Other income, net Foreign exchange gains (losses) Net corporate operating, interest and other Year Ended December 31, 2006 2005 2004 $ 115.9 $ 63.3 $ 29.0 (1.1) 29.0 1.5 91.4 11.1 (2.4) income and expense not allocated to segments (1.8) (0.4) (2.8) Consolidated income before taxes from continuing operations $ 142.0 $ 93.4 $ 97.3 The following reconciles total segment assets to consolidated total assets (in millions): Total segment assets Cash and other current assets Net property, plant and equipment excluding segment specific gross machinery and equipment Goodwill Other long-term assets Total assets December 31, 2006 2005 $ 785.1 $ 594.2 (50.8) 119.5 148.2 674.6 563.1 (35.3) 113.3 110.9 $ 1,596.2 $ 1,426.6 p49 Bio-Rad Laboratories | Annual Report 2006 Notes to Consolidated Financial Statements (continued) The following presents sales to external customers by geographic area based primarily on the location of the use of the product or service (in millions): Europe Pacific Rim United States Other (primarily Canada and Latin America) Total sales Year Ended December 31, 2006 2005 2004 $ 559.4 $ 508.3 $ 200.7 443.7 70.1 193.6 421.3 57.8 502.2 168.2 370.2 49.4 $ 1,273.9 $ 1,181.0 $ 1,090.0 The following presents long-lived assets by geographic area based upon the location of the asset (in millions): Europe Pacific Rim United States Other (primarily Canada and Latin America) Total long-lived assets Year Ended December 31, 2006 2005 2004 $ 88.1 $ 75.0 $ 9.2 366.0 3.1 8.5 332.1 2.8 57.7 8.0 394.4 3.1 $ 466.4 $ 418.4 $ 463.2 p50 Bio-Rad Laboratories | Annual Report 2006 16. QUARTERLY FINANCIAL DATA (UNAUDITED) Summarized quarterly financial data for 2006 and 2005 are as follows (in millions, except per share data): 2006 Net sales Gross profit Net income Basic earnings per share Diluted earnings per share First Quarter Second Quarter Third Quarter Fourth Quarter $ 308.3 175.5 31.2 $ 1.19 $ 1.16 $ 317.7 184.7 32.3 $ 1.22 $ 1.20 $ 304.8 166.8 23.2 $ 0.88 $ 0.86 $ 343.1 185.6 16.6 $ 0.63 $ 0.61 2005 Net sales Gross profit Net income Basic earnings per share Diluted earnings per share 300 250 $ 299.2 166.4 33.5 $ 1.29 $ 1.26 $ 291.3 160.6 18.4 $ 0.71 $ 0.69 $ 283.2 156.8 16.2 $ 0.62 $ 0.61 $ 307.3 162.7 13.5 $ 0.51 $ 0.50 New Peer Group(1) Bio-Rad S R A In the fourth quarter of 2005, Bio-Rad recorded $19.8 million of impairment losses related to intangible and L L O long-lived assets (see Note 6). D 150 Former Peer Group(1) 200 100 50 17. STOCK PERFORMANCE GRAPH AMEX(1) The following graph compares the cumulative stockholder returns over the past five years for the Company’s Class A 2001 2002 2003 2004 2005 2006 0 Common Stock, the American Stock Exchange Market Value Index and a selected peer group, assuming $100 invested on December 31, 2001, and reinvestment of dividends if paid: S R A L L O D 300 250 200 150 100 50 0 Bio-Rad New Peer Group(1) Former Peer Group(1) AMEX(2) 2001 2002 2003 2004 2005 2006 (1) The New Peer Group consists of the following public companies: Applera Corp. (the Applied Biosystems group), Beckman Coulter, Becton Dickinson, Thermo Fisher Scientific, Invitrogen, Meridian Bioscience, Millipore, and PerkinElmer Inc. Companies in our peer group reflect our participation in two different markets: life science research products and clinical diagnostics. No single public or private company has a comparable mix of products which serve the same markets. In many cases, only one division of a peer group company competes in the same markets as we do. Collectively, however, our peer group reflects products and markets similar to those of Bio-Rad. In the past, we have included Diagnostics Products in our peer group but, as they have been acquired by Siemens in the past year, we no longer include them. We have added Thermo Fisher Scientific and Applera Corp. to form the New Peer Group as we believe that this revised peer group is a better representation of our competitors. The Former Peer Group reflects the peer group companies we used in prior years minus Diagnostics Products. (2)American Stock Exchange Market Value Index This stock performance graph shall not be deemed incorporated by reference by any general statement incorporating by reference into any filing under the Securities Act or the Exchange Act, and shall not otherwise be deemed filed under these Acts. p51 Bio-Rad Laboratories | Annual Report 2006 Report of Independent Registered Public Accounting Firm To the Board of Directors and Stockholders of Bio-Rad Laboratories, Inc., Hercules, California We have audited the accompanying consolidated balance sheets of Bio-Rad Laboratories, Inc. and subsidiaries (the “Company”) as of December 31, 2006 and 2005, and the related consolidated statements of income, stockholders’ equity, and cash flows for each of the three years in the period ended December 31, 2006. These financial state- ments are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, such consolidated financial statements present fairly, in all material respects, the financial position of Bio-Rad Laboratories, Inc. and subsidiaries as of December 31, 2006 and 2005, and the results of their opera- tions and their cash flows for each of the three years in the period ended December 31, 2006, in conformity with accounting principles generally accepted in the United States of America. As discussed in Notes 1 and 10 the Company changed its method of accounting for share-based payment arrangements in 2006 to conform to Statement of Financial Accounting Standards No. 123(R), “Share-Based Payment.” We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the effectiveness of the Company’s internal control over financial reporting as of December 31, 2006, based on the criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated February 28, 2007 expressed an unqualified opinion on the effectiveness of the Company’s internal control over financial reporting. San Francisco, California February 28, 2007 p52 Bio-Rad Laboratories | Annual Report 2006 Management’s Discussion and Analysis MANAGEMENT’S DISCUSSION AND ANALYSIS OF RESULTS OF OPERATIONS AND FINANCIAL CONDITION This discussion should be read in conjunction with the information contained in Bio-Rad’s Consolidated Financial Statements and the accompanying notes which are an integral part of the statements. References are to the Notes to Consolidated Financial Statements. Other than statements of historical fact, statements made in this Annual Report include forward looking state- ments, such as statements with respect to our future financial performance, operating results, plans and objectives that involve risk and uncertainties. We have based these forward looking statements on our current expectations and projections about future events. However, actual results may differ materially from those currently anticipated depending on a variety of risk factors including among other things: our ability to successfully develop and market new products; our reliance on and access to necessary intellectual property; our ability to successfully integrate any acquired business; our substantial leverage and ability to service our debt; competition in and government regulation of the industries in which we operate; and the monetary policies of various countries. We undertake no obligation to publicly update or revise any forward looking statements, whether as a result of new information, future events, or otherwise. Overview Bio-Rad is a multinational manufacturer and worldwide distributor of our own life science research and clinical diagnostics products. Our business is organized into two primary segments, Life Science and Clinical Diagnostics, with the mission to provide scientists with specialized tools needed for biological research and clinical diagnostics. We sell more than 8,000 products and services to a diverse client base comprised of scientific research, healthcare, education and government customers worldwide. We manufacture and supply our customers with a range of reagents, apparatus and equipment to separate complex chemical and biological materials and to identify, analyze and purify components. Because our customers require replication of results in manufacturing processes, research experiments and diagnostic tests, much of our revenues are recurring. Approximately 35% of our 2006 consolidated net sales are from the United States and 65% are from overseas, largely denominated in local currency with the majority of these sales in Euros, Yen and British Sterling. As a result, our consolidated net sales expressed in dollars benefit when the U.S. dollar weakens and suffers when the U.S. dollar strengthens in relation to other currencies. Currency fluctuations benefited our consolidated net sales expressed in U.S. dollars in 2006 and 2005. The market for reagents and apparatus remains good while growth rates have slowed due to both public and private grant funding being more measured. The market for large capital equipment has slowed, as many pharmaceutical and biotechnology customers delayed or reduced their capital spending. Bio-Rad is generally less impacted by trends in capital spending as lower priced reagents and apparatus comprise more than 70% of product sales. p53 Bio-Rad Laboratories | Annual Report 2006 Management’s Discussion and Analysis (continued) The following shows gross profit and expense items as a percentage of net sales: Net sales Cost of goods sold Gross profit Selling, general and administrative expense Product research and development expense, excluding in-process research and development Income from continuing operations Discontinued operations Net income Year Ended December 31, 2006 2005 2004 100.0 100.0 100.0 44.1 55.9 34.5 9.7 8.1 — 8.1 45.3 54.7 35.2 9.7 6.6 0.3 6.9 44.0 56.0 34.7 9.9 6.1 0.2 6.3 We intend that the discussion of our results of operations and financial condition that follow will assist you in understanding how accounting principles, policies and estimates affect our results, and the significant factors that caused changes in our operations and financial position for the years ended December 31, 2006 and 2005. CRITICAL ACCOUNTING POLICIES AND ESTIMATES The accompanying discussion and analysis of Bio-Rad’s financial condition and results of operations are based upon the consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States (GAAP). The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and contingencies as of the date of the financial statements and reported amounts of revenues and expenses during the reporting periods. We evaluate our estimates on an on-going basis. Bio-Rad bases its estimates on historical experience and on other assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. However, future events may cause us to change our assumptions and estimates requiring routine adjustment. Actual results could differ from these estimates. We have determined that for the periods reported in our 2006 Annual Report, the following accounting policies and estimates are critical in understanding the financial condition and results of our operations. Accounting for Income Taxes As part of the process of preparing consolidated financial statements, management is required to estimate our income taxes in each of the jurisdictions in which we operate. This process involves estimating our actual current tax exposure together with assessing temporary differences resulting from differing treatment of items for tax and accounting purposes. These differences result in deferred tax assets and liabilities, which are included within the consolidated balance sheet. Management must then assess the likelihood that the deferred tax assets will be recovered from future taxable income and to the extent management believes that recovery is not likely, a valuation allowance must be established. To the extent management establishes a valuation allowance or increases this allowance in a period, an increase to expense within the provision for income taxes in the statement of income will result. Significant management judgment is required in determining the provision for income taxes, deferred tax assets and liabilities and any valuation allowance recorded in connection with the deferred tax assets. We have recorded a valuation p54 Bio-Rad Laboratories | Annual Report 2006 allowance of $26.5 million and $17.7 million as of December 31, 2006, and 2005, respectively, due to uncertainties related to our ability to utilize some of the deferred tax assets, primarily consisting of certain foreign net operating losses carried forward, before they expire. The valuation allowance is based on management’s current estimates of taxable income for the jurisdictions in which Bio-Rad operates and the period over which the deferred tax assets will be recoverable. In the event that actual results differ from these estimates, or these estimates are adjusted in future periods, an additional valuation allowance may need to be established which would increase the tax provision, lowering income and impacting Bio-Rad’s financial position. Should realization of these deferred assets previously reserved occur, the provision for income tax would decrease, raising income and positively impacting Bio-Rad’s financial position. Valuation of Long-lived and Intangible Assets and Goodwill We assess the impairment of identifiable intangibles, long-lived assets and related goodwill and enterprise level goodwill whenever events or changes in circumstances indicate that the carrying value may not be recoverable. Projected future operating results and cash flows of the reporting units’ asset or asset group are used to establish the fair value used in evaluating the carrying value of long-lived, intangible assets and goodwill. Factors that we consider important which could trigger an impairment review include the following: • significant under-performance relative to expected, historical or projected future operating results; • significant changes in the manner of use of the long-lived assets, intangible assets or the strategy for our overall business; • significant negative industry or economic trends. When Bio-Rad determines that the carrying value of intangibles, long-lived assets or enterprise level goodwill may not be recoverable based upon the existence of one or more of the above indicators of impairment, we test for any impairment based on a projected undiscounted cash flow method. There were no impairments taken in the years 2006 and 2004. For the year 2005, that review indicated an impair- ment had taken place in purchased intangible assets related to existing thermal cycler and microarray technology. Valuation of Inventories Bio-Rad values inventory at the lower of the actual cost to purchase and/or manufacture the inventory, or the current estimated market value of the inventory. We review inventory quantities on hand and record a provision for excess and obsolete inventory based primarily on an estimated forecast of product demand and production requirements for the next twelve months on a quarterly basis or, if warranted by the circumstances, more frequently. In addition, our industry is characterized by technological change, frequent new product development and product obsolescence that could result in an increase in the amount of obsolete inventory quantities on hand. Our estimates of future product demand may prove to be inaccurate, in which case we may have understated or overstated the valuation allowance required for excess and obsolete inventory. In the future, if inventory is determined to be overvalued, we would be required to recognize such costs in our cost of goods sold at the time of such determination by initiating or increasing the valuation allowance. Likewise, if the inventory valuation allowance is determined to be no longer required, we may have over-reported cost of goods sold in previous periods and would be required to recognize such additional operating income at the time of sale until the inventory allowance is depleted. In no case is inven- tory valued at an amount greater than cost. Therefore, although we make efforts to ensure the accuracy of our forecasts of future product demand, any significant unanticipated changes in demand, technological developments or regulations could have a significant impact on the value of our inventory and reported operating results. p55 Bio-Rad Laboratories | Annual Report 2006 Management’s Discussion and Analysis (continued) Allowance for Doubtful Accounts Bio-Rad maintains an allowance for doubtful accounts for estimated losses resulting from the inability of our customers to make required payments. The amount of the allowance is determined by analyzing known uncollectible accounts, the age of our receivables, economic conditions in the customers’ country or industry, historical losses and our customers’ general credit-worthiness. Amounts later determined and specifically identified to be uncollectible are charged or written off against this reserve. This valuation allowance is reviewed on a quarterly basis to determine whether an increase or decrease is warranted. Should the estimates be higher than the actual uncollectible accounts, we would report lower profitability when the estimates are made and higher profitability when the receivable is collected. Warranty Reserves Bio-Rad warrants certain equipment against defects in design, materials and workmanship, generally for a period of one year. Upon delivery and on acceptance of that equipment, we establish, as part of cost of goods sold, a provi- sion for the expected costs of such warranty based on historical experience, specific warranty terms and customer feedback. A review is performed on a quarterly basis to assess the adequacy of our warranty reserve and it is adjusted if necessary. The warranty percentage and accrual are based on actual experience and expected future costs to be incurred. Should realized costs be higher than expected costs, cost of goods sold would be lower in the period of estimation and higher when realized. Litigation Reserves Estimated amounts for claims that are probable and can be reasonably estimated are recorded as liabilities in the consolidated balance sheets. The likelihood of a material change in these estimated reserves is dependent on the possible outcome of settlement negotiations, regulatory or judicial review and the development of facts and circumstances in extended litigation which could change claims or assessments when both the amount and range of loss on some outstanding litigation is uncertain. We are obligated to disclose in the footnotes of the financial statements when we are unable to make a reasonable estimate of the liability that could result from unfavorable outcomes in litigation. As events occur, we will assess the potential liability related to our pending litigation and revise our estimates. Such revisions in our estimates of the potential liability could materially impact our results of operations and financial position. RECENT ACCOUNTING PRONOUNCEMENTS In June 2006, the FASB issued Interpretation No. 48, Accounting for Uncertainties in Income Taxes, an interpretation of SFAS No. 109, Accounting For Income Taxes (FIN 48). FIN 48 prescribes a comprehensive model for how com- panies should recognize, measure, present, and disclose in their financial statements uncertain tax positions taken or expected to be taken on a tax return. Under FIN 48, tax positions must initially be recognized in the financial statements when it is more likely than not the position will be sustained upon examination by the tax authorities. Such tax positions must initially and subsequently be measured as the largest amount of tax benefit that is greater than 50% likely of being realized upon ultimate settlement with the tax authority assuming full knowledge of the position and relevant facts. FIN 48 is effective for fiscal years beginning after December 15, 2006. Bio-Rad will be required to apply the provisions of FIN 48 to all tax positions upon initial adoption on January 1, 2007, with any cumulative effect adjustment to be recognized as an adjustment to retained earnings. Additional FASB guidance on FIN 48 is pending. As a result, we are currently unable to finalize our estimate of the impact that adopting this Interpretation will have on our financial statements. Based on our analysis to date, however, we believe that the adoption of FIN 48 may result in recording an additional liability. p56 Bio-Rad Laboratories | Annual Report 2006 In December 2004, the FASB issued SFAS 123(R), Share-Based Payment, which is a revision of SFAS 123, Accounting for Stock-Based Compensation, and supersedes APB Opinion No. 25, Accounting for Stock Issued to Employees. SFAS 123(R) requires companies to recognize the cost of employee services received in exchange for awards of equity instruments, based on the grant date fair value of those awards in their financial statements. Pro forma disclosure is no longer an alternative under the new Standard. SFAS 123(R) also requires the benefits associated with tax deductions in excess of recognized compensation cost to be reported as a financing cash flow rather than as an operating cash flow as was previously required. Bio-Rad has adopted the provisions of SFAS 123(R) beginning January 1, 2006 under the modified prospective transition method. Under this method, compensation cost for the unvested portion of previously granted awards and all new awards will be recognized on or after the date of adoption. The compensation cost related to unvested awards at the date of adoption is based on the grant-date fair value of those awards as calculated for pro forma disclosures under the original SFAS 123 as adjusted for the effect of estimated forfeiture rates. CORPORATE RESULTS — SALES, MARGINS AND EXPENSES Bio-Rad net sales increased 8% for the year 2006 to $1,273.9 million. The impact of foreign exchange translation aided sales growth by approximately 0.2%. The Life Science segment achieved sales growth of 5% in 2006 with little or no impact from foreign exchange translation. Excluding the impact of the food science product line, the Life Science segment grew by 11% including any foreign exchange translation impact. Increased sales were generated by process media sales, multi-analyte detection, and the return of thermal cycler sales after the legal settlement allowed our products from the MJ acquisition to be sold. Sales to Asia and to developing markets in Eastern Europe were particularly strong. The decline in the sales of food science products continued in 2006 as increased competition and less government mandated testing led to lower prices and unit sales. The Clinical Diagnostics segment achieved sales growth of 11% in 2006 aided by an overall favorable impact from foreign currency translation of 0.3%. Significant sales growth was provided by blood virus and quality control products. Included in the blood virus sales is royalty revenue of $11.7 million from the settlement of a dispute over past infringement. The Clinical Diagnostics segment was particularly successful in Eastern Europe where it received some large government tenders. The Middle East, Asia and Latin America regions also contributed significantly to diagnostics growth. These large tenders are subject to intense competition and may not be either available in subsequent years or awarded to us. Diabetes and clinical microbiology products also contributed to sales growth but not to the same extent. Bio-Rad net sales for the year 2005 were $1,181.0 million, an increase of 8.3% over the prior year. The impact of foreign exchange translation throughout the year provided growth from foreign denominated net sales of approximately 1.1% for the full year. p57 Bio-Rad Laboratories | Annual Report 2006 Management’s Discussion and Analysis (continued) The Life Science segment had sales growth of 9.0% in 2005, benefiting from an approximate 0.8% increase due to foreign exchange. Currency neutral sales growth of 8.2% was provided by the acquisition of MJ Research, pro- cess media sales, multi-analyte detection, and protein separation apparatus and reagents. Offsetting these specific growth areas was a decline in food science products as the average pricing for our BSE tests declined year over year in a very competitive market. During the fourth quarter, we were enjoined by court order not to sell or service MJ products in the United States, which negatively impacted sales. The Clinical Diagnostics segment had sales growth of 7.3% in 2005, benefiting from an approximate 1.4% increase due to foreign exchange. Currency neutral sales growth was 5.9% in the Clinical Diagnostics segment. Our quality control products had growth across several product lines. Diagnostic tests for diabetes monitoring, genetic disorder identification, and improved demand for blood virus products in the U.S. and Asia also contributed to overall growth. The 2006 consolidated gross margin of 55.9% represents an improvement of 1.2% from the prior year. This improvement was largely the result of higher gross margins in the Clinical Diagnostics segment. Life Science segment margins improved by approximately one quarter of one percent as the positive impact of sales increases, a reduction in customer warranty costs from the thermal cycler injunction and the reduction in MJ intangibles amortization were offset by declining food science gross margin caused by lower average selling prices. Clinical Diagnostics segment margins improved near 2%. The receipt of back royalties with no associated costs were one factor in the improvement. A more substantial impact though, is higher sales volumes improving factory overhead utilization while actively limiting the growth in factory overhead costs. The 2005 consolidated gross margins declined to 54.7% in the current year from 56.0%. The decline in the Life Science segment’s gross margin accounts for the decline for Bio-Rad as a whole. Several factors contributed to the decline in the Life Science segment. Lower average pricing on the BSE product lines and the court-ordered halt to MJ product sales and service relating to the patent litigation with ABI resulted in the immediate expensing of all production costs leading to higher service and warranty expense as customer accommodations were made. The Clinical Diagnostics segment’s margin improved by less than one percent. Moderation in the increase of plant overhead costs and lower reagent rental depreciation were contributing factors to this improvement. Consolidated selling, general and administrative expense (SG&A) was 34.5% of net sales for the year 2006 compared to 35.2% for the year 2005. The increase of $22.9 million includes the expensing of stock options under SFAS 123(R) of $4.2 million. Personnel costs including stock option expense accounted for approximately half of the year over year increase in SG&A costs. Third party agent commissions and increased travel and related expenses accounted for approximately a third of the total increase. On the segment level, the Life Science segment generally held expenses flat with the Clinical Diagnostics segment growing at a rate below that of sales growth. Foreign exchange translation had little impact on SG&A expense for the year 2006. Consolidated selling, general and administrative expense was 35.2% of net sales for the year 2005 compared to 34.7% for the year 2004. The Life Science segment and Corporate shared services added expenses at a rate that exceeded sales growth. The Life Science segment increases are attributable to higher personnel and facilities costs related to the acquisition of MJ, legal expenses related to patent litigation, the amortization of intangibles and an increase in the experience of uncollectible receivables. Corporate shared services had increased spending in information p58 Bio-Rad Laboratories | Annual Report 2006 technology, acquisition related expenses and legal fees. The Clinical Diagnostics segment’s SG&A expense grew at a rate slower than sales. The largest element of absolute cost is personnel, which also was responsible for generating the most growth in expenses. Overall for 2005, Bio-Rad increased costs associated with regulatory requirements for global tax and audit compliance and security and disaster recovery for our information technology infrastructure. Additionally, we incurred professional service fees in association with the attempted acquisition of BioSource International, Inc. and settling the Instrumentation Laboratory litigation. Product research and development expense in 2006 remained unchanged at 9.7% of sales after excluding the purchased in-process R&D from the Ciphergen and Blackhawk acquisitions. In absolute dollars, each segment had growth in R&D spending with the Clinical Diagnostics segment having approximately twice the growth of the Life Science segment. Life Science segment spending was focused in the areas of proteomics, process chromatography and multi-analyte detection. Clinical Diagnostics segment areas of interest include expanded software data man- agement for the quality control product line, expanded tests for the BioPlex® 2200 platform and improvements to diabetes monitoring and blood virus diagnostic tests and systems. Product research and development expense in 2005 declined to 9.7% of sales after adjusting for the $14.6 million of purchased in-process R&D from 2004 acquisitions. In absolute dollars, each segment had growth with Life Science segment increasing more than the Clinical Diagnostics segment. The Life Science segment concentrated on research and development in amplification and protein interaction technologies. The Clinical Diagnostics segment concentrated on automation for the serology, autoimmune and blood virus products as well as the segment’s quality control products. CORPORATE RESULTS Interest expense declined by approximately $0.6 million in 2006 compared to the prior year. The decline reflects lower average borrowings on local lines of credit in 2006 compared to the prior year. The majority of current interest costs are associated with the $425.0 million in Senior Subordinated notes at fixed interest rates of 7.5% and 6.125%. This $425.0 million of fixed rate borrowing represents greater than 99% of our total interest bearing debt. Interest expense increased in 2005 to $32.6 million, from $20.2 million in the prior year. The year 2005 had approximately $434.7 million of average borrowings. The increase reflects that in late December 2004, we bor- rowed an additional $200.0 million in a private placement of Senior Subordinated Notes at 6.125%. This addition- al borrowing has substantially caused all of the 2005 increase in interest expense which includes the amortization of bond origination fees. We now have two principal borrowings: the $225 million 7.5% bonds due 2013, and the $200 million 6.125% bonds due 2014. Foreign exchange (gains) losses for 2006 and 2005 were $1.1 million and ($1.5) million, respectively. The 2006 losses are principally the result of the estimating process involved in the timing of shipments and settling of intercompany debt. The gains in 2005 are attributable mainly to the strengthening of the Brazilian Real versus the U.S. dollar. p59 Bio-Rad Laboratories | Annual Report 2006 Management’s Discussion and Analysis (continued) Other income and expense for the year 2006 is principally comprised of $22.3 million of investment income from interest on our cash, cash equivalents and short-term investments. The amount is higher than the previous year as returns on short-term debt investments yielded higher returns in 2006 than in 2005. Also included in other income is $4.7 million relating to a facilitation fee received and a gain on the tendering of our shares of Accent Semicon- ductor Technology Inc. for shares in Nanometrics Inc. after the two companies merged. Other income and expense for the year 2005 includes two atypical events. First is the sale of our investment in IL for $12 million resulting in a $7.9 million gain. Second is a gain of $3.3 million on the tendering of our shares in BioSource, a potential acquisition that later accepted a buy-out from another company. The year 2005 includes $16.7 million of interest and investment income generated by our net cash position and notes receivable. Bio-Rad’s consolidated effective tax rate was 27%, 17% and 32% in 2006, 2005 and 2004, respectively. The 2006, 2005 and 2004 effective tax rates reflect tax rate benefits of 3%, 6% and 2% respectively for nontaxable dividend income, and 2%, 2% and 2% respectively for tax credits. The 2006, 2005 and 2004 effective tax rates also reflect benefits in the difference between U.S. and foreign taxes net of foreign tax credits of 1%, 7% and 1% respectively. The tax rate benefit of 7% for 2005 is related to certain one time events in France and the U.K. The 2005 effective tax rate also reflects a one time benefit of 5% related to a capital loss for tax purposes. The tax rate for all years reflects a tax benefit related to export sales. Our effective tax rate may be impacted in the future, either favorably or unfavorably, by many factors including but not limited to statutory tax rates, changes in existing laws or regulations, tax audits and settlements, and generation of tax credits. FINANCIAL CONDITION Bio-Rad operates and conducts business globally, primarily through subsidiary companies established in the markets in which we trade. Goods are manufactured in a small number of locations, and intermediate or finished products are then shipped for completion and/or distribution to facilities around the globe. Our product mix is diversified, and certain products compete largely on product efficacy, while others compete on price. Gross margins are generally sufficient to exceed normal operating costs. Funding for research and development of new products as well as routine outflows of capital expenditure, repayment of maturing debt and tax expense are covered by cash flow from operations. We currently operate with a high level of interest coverage and our market capitalization is high relative to our level of debt. In addition to the strong positive cash flow from operating activities, additional liquidity is readily available via the sale of short-term investments. At December 31, 2006, we had available $488.1 million in cash, cash equivalents and short-term investments, and $30.1 million under international lines of credit. Under the $150.0 million restated and amended Revolving Credit Facility, we have $145.6 million available with $4.4 million reserved for standby letters of credit issued by our banks to guarantee our obligations to certain insurance companies. Management believes that this availability, together with cash flow from operations, will be adequate to meet our current objectives for operations, research and development, capital additions for plant, equipment and systems and an acquisition of moderate proportions. p60 Bio-Rad Laboratories | Annual Report 2006 Cash Flow from Operations Net cash provided by operations was $118.2 million, $108.3 million and $123.1 million in 2006, 2005 and 2004, respectively. The net improvement of $9.9 million represents first, approximately a $25 million improvement in the net change in cash received from customers and cash paid to suppliers, along with higher interest income and lower tax payments. Second, offsetting these cash flows are the payments to ABI to settle the litigation arising from the acquisition of MJ Research. During 2006, accounts receivable rose on both higher sales and an increase in days outstanding as Asia, Southern and Eastern Europe often have longer credit terms and more complex collection procedures resulting in longer col- lection times. Inventory increased to support higher sales volume, new product introduction, internalizing manu- facturing from an OEM supplier, and longer lead times and batch sizes to meet customer demand for our quality control product line. Bio-Rad’s management regularly reviews the allowance for uncollectible receivables and believes net accounts receivable are fully realizable. Management routinely reviews inventory for the impact of obsolesence and changes in market prices caused by the introduction of new products, technologies and in government reimbursement policies. Cash Flow from Investing Activities Net capital expenditures in 2006 totaled $53.0 million, compared to $36.1 million and $60.5 million in 2005 and 2004, respectively. Net capital expenditures for 2006 reflect investment in manufacturing and warehouse equipment and improvements to new information technology systems. Spending on reagent rental instruments increased to $16.3 million. We place reagent rental instruments with our Clinical Diagnostics customers for use with our clinical reagents. We increased in 2006 our investment in business systems to modernize and standardize distribution capa- bilities and enhance data communication. Other ongoing expenditures are for the replacement and improvement of production equipment and facilities to meet the necessary Good Manufacturing Practices (GMP) mandated by the Food and Drug Administration (FDA) for the Clinical Diagnostics segment and to meet the requirements of other regulatory bodies as well as many customers in our Life Science segment. Net cash used in investing activities was $207.7 million for the year 2006. During the year we paid cash for the acquisition of both Ciphergen and Blackhawk, while 2005 had no comparable acquisition activity. The net change in purchases and sales of marketable securities and investments represents our attempt to earn an increase in overall returns on securities that do not comply with the definition of a cash equivalent. Cash and short-term investments, in part, represent our resources available to make an acquisition before drawing on our available credit facilities and incurring additional debt. Actual acquisition spending, however, may vary depending upon the availability and timing of a suitable candidate. Cash Flow from Financing Activities Net cash flow provided from financing was $10.2 million for 2006 and principally reflects the cash flow for the exercise of stock options and payments from the ESPP. During the fourth quarter of 2004, we borrowed $200 million at 6.125% due 2014 in a private placement. This borrowing, along with the $225 million at 7.5% due 2013, provides us with capital at a fixed rate for the next eight and seven years, respectively. Our focus for the company is to make an p61 Bio-Rad Laboratories | Annual Report 2006 Management’s Discussion and Analysis (continued) acquisition to supplement our internal growth. We routinely meet and discuss potential acquisitions with specific companies, principals or their agents. Until such time that we identify an investment opportunity (generally an acquisition), no cash and short-term investment change is contemplated as our current position provides adequate liquidity. The $150.0 million revolving credit facility is secured by substantially all of our personal property assets and the assets of our domestic subsidiaries and 65% of the capital stock of certain foreign subsidiaries, and is guaranteed by all of our existing and future domestic subsidiaries (other than immaterial domestic subsidiaries as defined for purposes of the new credit facility). The Board of Directors has authorized us to repurchase up to $18 million of Bio-Rad’s common stock over an indefinite period of time. Through December 31, 2006, we have cumulatively repurchased 1,179,272 shares of Class A Common Stock and 60,000 shares of Class B Common Stock for a total of $14.7 million. Our credit agreements restrict our ability to repurchase our own stock. There were no share repurchases made during 2006 or 2005. CONTRACTUAL OBLIGATIONS The following summarizes certain of our contractual obligations as of December 31, 2006 and the effect such obligations are expected to have on our cash flows in future periods (in millions): Contractual Obligations Long-term debt, including current portion (1) Interest payments Operating lease obligations (2) Purchase obligations (3) Long-term liabilities Total Less Than One Year 426.1 216.2 84.8 17.2 28.7 0.5 29.1 27.7 13.6 — 1-3 Years 0.5 87.4 31.4 2.8 10.2 3-5 More than 5 Years Years 0.1 425.0 87.4 15.8 0.8 1.2 12.3 9.9 — 17.3 (1) These amounts represent expected cash payments, include capital lease obligations and are included in our Consolidated Balance Sheets. See Note 7 of the Consolidated Financial Statements for additional information about our debt. (2) Operating lease obligations are described in Note 13 of the Consolidated Financial Statements. (3) Purchase obligations include agreements to purchase goods or services that are enforceable and legally binding on Bio-Rad and that specify all significant terms. Purchase obligations exclude agreements that are cancelable without penalty. p62 Bio-Rad Laboratories | Annual Report 2006 FINANCIAL RISK MANAGEMENT The main goal of Bio-Rad’s financial risk management program is to reduce the variance in expected cash flows arising from unexpected foreign exchange rate and interest rate changes. Financial exposures are managed through operational means and by using various financial instruments, including cash and liquid resources, borrowings, spot foreign exchange contracts, and derivatives. The derivative instruments used are principally comprised of forward foreign exchange contracts. No derivative financial instruments are entered into for the purpose of trading or speculation. Company policy requires that all derivative positions are undertaken to manage the risks arising from underlying business activities. These derivative transactions do not qualify for hedge accounting treatment under SFAS 133, Accounting for Derivative Instruments and Hedging Activities. Derivative instruments used in these transactions are valued at fair value and changes in fair value are included in reported earnings. Foreign Exchange Risk We operate and conduct business in many countries and are exposed to movements in foreign currency exchange rates. We face transactional currency exposures that arise when we enter into transactions denominated in currencies other than U.S. dollars. Additionally, our consolidated net equity is impacted by the conversion of the net assets of our international subsidiaries for which the functional currency is not the U.S. dollar. Foreign currency exposures are managed on a centralized basis. This allows for the netting of natural offsets and lowers transaction costs and net exposures. Where possible, we seek to manage our foreign exchange risk in part through operational means, including matching same-currency revenues to same currency costs, and same-currency assets to same-currency liabilities. Moreover, weakening in one currency can often be offset by strengthening in another currency. Foreign exchange risk is also managed through the use of forward foreign exchange contracts. Positions are primarily in Euro, British Sterling and Japanese Yen. The majority of forward contracts are for periods of 90 days or less. We record the change in value of our foreign currency receivables and payables as a Foreign exchange (gain) loss on our Consolidated Statements of Income along with the change in fair market value of the forward exchange contract used as an economic hedge of those assets or liabilities. Our forward contract holdings at year-end were analyzed to determine their sensitivity to fluctuations in foreign currency exchange rates. All other variables were held constant. Market risk associated with derivative holdings is the potential change in fair value of derivative positions arising from an adverse movement in foreign exchange rates. An adverse change of 10% on quoted foreign exchange rates would result in an approximate net-present-value loss of $7 million on our derivative position. This impact of a change in exchange rates excludes the offset derived from the change in value of the underlying assets and liabilities, which could reduce the adverse effect significantly. Interest Rate Risk of Debt Instruments Bio-Rad centrally manages the short-term cash surpluses and shortfalls of its subsidiaries. Our holdings of variable rate debt instruments at year-end were analyzed to determine their sensitivity to movements in interest rates. Due to the relatively small amount of short-term variable rate debt we have outstanding, there would not be a material impact to earnings or cash flows if interest rates moved adversely by 10%. Our long-term debt consists primarily of fixed-rate instruments, and is thus insulated from interest rate changes. Thus, as of December 31, 2006 the overall interest rate risk associated with our debt was not significant. p63 Bio-Rad Laboratories | Annual Report 2006 Corporate Information Directors David Schwartz Chairman of the Board James J. Bennett Director Louis Drapeau Director Albert J. Hillman Director Ruediger Naumann-Etienne Director Alice N. Schwartz Director Norman Schwartz Director Sanford S. Wadler Vice President, General Counsel and Secretary Ronald W. Hutton Treasurer James R. Stark Corporate Controller Other Executives Bruce Bartholomew Manager, North America Sales, Clinical Diagnostics Steve Binder Director, Technology Development, Clinical Diagnostics Officers David Schwartz Chairman of the Board Patrick Bugeon Group Operations Manager, France Clinical Diagnostics Norman Schwartz President and Chief Executive Officer John Bussell Manager, Clinical Systems Brad Crutchfield Vice President and Group Manager, Life Science John Goetz Vice President and Group Manager, Clinical Diagnostics Giovanni Magni Vice President and International Sales Manager Christine A. Tsingos Vice President and Chief Financial Officer Francois Capit Regional Manager, Asia Pacific Patrick Carroll Manager, North America Sales, Life Science Jean-Marc Chermette Manager, Food Science Colleen Corey Director, Corporate Human Resources Diane Dahowski Manager, BioPlex Patrice Deletoille Manager, Blood Virus Annual Meeting The Annual Meeting of Stockholders will be held on Tuesday, April 24, 2007 at 4 PM, Pacific Time, at the Corporate Offices of the Company in Hercules, California. Bio-Rad will provide without charge to each stockholder, upon written request to the Secretary, a copy of its 2006 Annual Report filed with the Securities and Exchange Commission on Form 10-K. Transfer Agent Computershare Investor Services LLC 2 North LaSalle Street Chicago, Illinois 60602 Tel: 312-360-5132 Fax: 312-601-4332 www.computershare.com Auditors Deloitte & Touche LLP San Francisco, California Common Stock Traded on the American Stock Exchange Class A Common Stock Symbol BIO Class B Common Stock Symbol BIOb David Forrester Regional Manager, Europe John Hertia Group Operations Manager, Life Science Scott Jenest Manager, Manufacturing, Life Science Leo Kaabi Manager, Quality Systems Bill Kuhlman Manager, Process Chromatography Ann Madden Manager, Clinical Microbiology Paul Menter Manager, Laboratory Separations Daniel Merle Manager, Business Development, Clinical Diagnostics Todd Morrill Manager, Business Development, Life Science Leonard Pulig Manager, Marketing, Life Science John Senaldi Manager, Protein Function Sanjiv Suri Regional Manager, Emerging Markets Sadashi Suzuki Regional Manager, Japan Annette Tumolo Manager, Gene Expression p64 Bio-Rad Laboratories 1000 Alfred Nobel Drive Hercules, CA 94547 510-724-7000 TEL 510-741-5817 FAX www.bio-rad.com

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