Bionomics Ltd
Annual Report 2013

Plain-text annual report

2013 BIONOMICS ANNUAL REPORT A LEADING INTERNATIONAL DRUG DISCOVERY AND DEVELOPMENT COMPANY 1 CONTENTS PG 1 VISION PG 2 PG 3 PG 4 HIGHLIGHTS CHAIRMAN’S LETTER CEO & MANAGING DIRECTOR’S REPORT PG 14 PIPELINE PG 15 INTELLECTUAL PROPERTY PORTFOLIO PG 18 BOARD OF DIRECTORS PG 20 MANAGEMENT PG 21 CORPORATE GOVERNANCE STATEMENT PG 26 DIRECTORS’ REPORT PG 39 ANNUAL FINANCIAL STATEMENTS PG 82 INDEPENDENT AUDIT REPORT PG 84 SHAREHOLDER INFORMATION PG 86 COMPANY PARTICULARS FRONT COVER FROM LEFT: Dr Julia Crossman, Senior Research Scientist Dr Dharam Paul, Director of Chemistry & CMC Dr Rajinder Singh, Senior Research Scientist BIONOMICS IS DISCOVERING AND DEVELOPING INNOVATIVE THERAPEUTICS FOR SERIOUS MEDICAL CONDITIONS, WORKING WITH PARTNERS TO ACHIEVE SIGNFICANT OUTCOMES FOR PATIENTS, SHAREHOLDERS AND EMPLOYEES Bionomics is a leader in the discovery and development of innovative biopharmaceuticals with operations in Australia, Europe and US. The company undertakes discovery, development and strategic partnering of first class and best in class drugs to treat patients with serious medical conditions including cancer and central nervous system disorders. Bionomics utilizes key global, strategic partnerships for the commercialisation of its drugs. 2 HIGHLIGHTS R VASCULAR DISRUPTING AGENT BNC105 NEARING KEY PARTNERING PHASE E C N A C w w BNC105 Phase I renal cancer trial demonstrates clinical benefit w w Recruitment for Phase II trial for renal cancer completed w w Recruitment in Phase I ovarian cancer trial completed SECURED CANCER STEM CELL PROGRAMS AND RAPIDLY ADVANCING CSC PIPELINE w w Acquired US oncology franchise Eclipse Therapeutics, advancing cancer stem cell targeting antibody BNC101 w w Lonza commences manufacture of BNC101 in preparation for clinical trials CRC COLLABORATION YIELDS FIRST RESULTS w w Proof of Concept compound identified, reduces tumour size and cancer spread in preclinical model of melanoma w w IND application for IW-2143 (BNC210) submitted to the FDA and subsequently a US Phase I clinical w w A US$2 million milestone payment to Bionomics by Ironwood could be triggered through M IRONWOOD PARTNERSHIP PROGRESSES BNC210 E T S Y S progression of the Phase I program. trial was commenced by Ironwood. L A R T N E C S U O V R E N BNC375 DRUG CANDIDATE IDENTIFIED FROM ALPHA 7 PROGRAM w w Potential treatment for cognitive impairment in Alzheimer’s disease, Parkinson’s disease and other conditions where memory loss occurs w w Data presented at international and Australian scientific conferences attracts attention from potential partners PARTNERSHIP WITH MERCK ON PAIN PROGRAM w w Bionomics may earn up to US$172 million in option fees and clinical and development milestones plus royalties on product sales Kv1.3 PROGRAM DRIVING TOWARDS PARTNERSHIP w w Data package expanded beyond Multiple Sclerosis to Psoriasis E N U M M I E S A E S D I 3 CHAIRMAN’S LETTER DEAR SHAREHOLDER, Although I joined Bionomics only late last year, I have been following its progress with interest since its inception. Over the years I have seen the Company continue to leverage its core strengths in Cancer, Central Nervous System and Immune Diseases, developing a deep and valuable pipeline of drug compounds. WHAT MAKES THE BIONOMICS PIPELINE UNIqUELY VALUABLE ARE FOUR CORE FACTORS: OUR PEOPLE, OUR PLATFORM TECHNOLOGIES, OUR PARTNERSHIP STRATEGY AND FINALLY THE GLOBAL FORCES OF CHANGE TAKING PLACE ACROSS OUR INDUSTRY. Before I talk about our people I want to address the pathway we have chosen and where our strategy fits in the global context. Pharmaceutical researcher EvaluatePharma has estimated that there are US$290 billion of sales of big pharma products at risk from patent expirations between 2012 and 2018. The Bionomics business model is built on the industry’s urgent need to replace these drug compounds, while recognising that bringing blockbuster drugs through large scale clinical studies to market is both costly and inherently risky. That is why we have pursued a partnership approach which allows us to validate the value of our intellectual property and lay off risk, as we did with the Ironwood transaction in FY12 and more recently with Merck in partnering our pain program. To support this strategy, we have developed a deep, staged pipeline which offers us a continuing stream of product candidates giving us multiple shots on goal. Of course our ability to replenish the pipeline is key to securing our future. At Bionomics the depth of our world-class science and discovery platforms are underpinned by a highly capable team of people lead by our CEO & Managing Director Deborah Rathjen who earlier this year was named BioSpectrum Asia Person of the Year. Over the past year we have built on the global competencies of our team with the appointment of Dr José Iglesias to the role of Chief Medical Officer, Dr Jeremy Simpson as Vice President Clinical Development and Dr Forrest Fuller as Vice President Business Development. We also welcomed the addition of the team from Eclipse Therapeutics (Eclipse), including co-founders Dr Peter Chu and Dr Chris Reyes, following its acquisition by Bionomics in September 2012. Dr Jonathan Lim, Executive Chairman of Eclipse, also joined Bionomics’ Board ensuring continuity as Bionomics implemented its strategy in the highly promising area of cancer stem cells therapeutics. I also congratulate Dr Sue O’Connor, who has been with Bionomics now for ten years, for her promotion to Vice President of Neuroscience Research. With achievement of milestones such as the completion of enrolment in our Phase II renal cancer trial and the successful establishment of operations in San Diego, I believe that Bionomics has reached a key inflection point in our development and that the next twelve months will see us building on the successes of our partnership strategy, seen most recently in the Company’s partnership with Merck & Co. Partnering opportunities such GRAEME KAUFMAN, CHAIRMAN. as these are only possible when we make advances in our discovery and clinical trial programs and build our pipeline into a portfolio that is of high value. I am very excited by the breakthroughs we have made during the year in the exciting areas of cancer and central nervous system therapies and believe that these are an indication of Bionomics’ strong pipeline. With the support of our shareholders and the raising of an additional $16.4 million, Bionomics closed FY13 with $22.45 million in cash and I believe we are in a strong position to negotiate with multiple parties on these compounds. I would like to thank my fellow Directors, our CEO Deborah Rathjen and the entire Bionomics team for their efforts during the year and also our shareholders for their continued commitment to our business. Yours sincerely, Graeme Kaufman Chairman 4 OUR VISION IS TO BECOME A LEADING PLAYER IN THE GLOBAL DRUG DISCOVERY AND DEVELOPMENT BUSINESS WITH RECURRENT REVENUE STREAMS UNDERPINNED BY OUT-LICENSING AGREEMENTS AND A VALUABLE INTELLECTUAL PROPERTY PORTFOLIO OF COMPELLING DRUG CANDIDATES. DEBORAH RATHJEN CEO AND MANAGING DIRECTOR. CEO & MANAGING DIRECTOR’S REPORT DEAR SHAREHOLDER, The 2013 financial year has seen continued focus on building out our deep, staged pipeline, working with our partner Ironwood Pharmaceuticals to progress IW-2143 (BNC210) and positioning the business to secure additional value creating partnering opportunities that will lock in future revenue streams. Our vision is to become a leading player in the global drug discovery and development business with recurrent revenue streams underpinned by out-licensing agreements and a valuable intellectual property portfolio of compelling drug candidates. Bionomics’ strategy to leverage our core strengths in solid tumour oncology, central nervous system and immune disease therapies, has delivered a valuable portfolio of drug candidates that target multi-billion dollar market opportunities across those segments. During the year we added to that portfolio, organically via our “in house” proprietary drug discovery platforms and development capability as evidenced by BNC375 the Company’s drug candidate for Alzheimer’s Disease, as well as by the acquisition of a pipeline of complementary oncology assets, via the acquisition of Eclipse Therapeutics (Eclipse). We have also added to our team and this has enabled us to advance our programs rapidly, to validate our science and to attract the attention of key players seeking to fill their own product pipelines with new drug candidates like our own. Evidence of this is in the recently announced partnership with Merck & Co (known as MSD outside the US and Canada). On 31 July 2013 Bionomics announced an agreement to discover and develop novel small molecule candidates for the treatment of chronic pain, including neuropathic pain. Merck is a global pharmaceutical company and this research collaboration is validation of Bionomics’ drug discovery platforms ionX® and MultiCore®. It is also a further example of the Company’s partnership strategy. Under the terms of the agreement, Merck will have the option to exclusively license a compound from Bionomics for development and commercialisation. In return, Bionomics may receive option exercise fees and development and regulatory milestone payments of up to US$172 million. Bionomics may also be eligible for undisclosed royalties on net sales of products from the collaboration. Bionomics retains the right to develop and commercialise certain compounds for which Merck does not exercise its option. The initial period of the research program will be two years. During the year Bionomics also demonstrated its ability to progress the development of its lead cancer program. BNC105, Bionomics’ dual acting vascular disrupting agent for the treatment of solid tumours reached a significant milestone with enrolment into the multinational Phase II clinical trials in patients suffering metastatic renal cancer and who have failed prior treatment with tyrosine kinase inhibitors. 5 CEO & MANAGING DIRECTOR’S REPORT Yana Kolev, Research Assistant SECURING A SOLID fINANCIAL UNDERPINNING From a financial perspective we are pleased to report continued growth in our revenue and other income which is up 19% over the prior year to $11.83 million. Revenue growth comes from payments that were received under the Ironwood out-licensing arrangement, contract service fees earned by Neurofit and funds received under the R&D tax incentive. We will continue to position the business to receive research and development funding including grants where available. Having a global business with operations in the US, Europe and Australia provides us with a solid business development and regulatory platform, but it also brings with it the opportunity to participate in a much deeper pool of funds allocated to drug discovery programs like our own. Earlier this year we saw an opportunity to advance our Alzheimer’s drug candidate BNC375 and have been building a data package that has formed the basis for our discussions with potential partners. Similarly, in cancer stem cells Bionomics has moved quickly to showcase its BNC101 antibody at major industry events. These initiatives have been supported by the Company’s raising of $16.4 million in capital from new and existing shareholders earlier this year. As at 30 June 2013 Bionomics held $22.45 million in cash and we are confident we now have the resources we need to continue to advance both of those programs and to negotiate lucrative partnership deals with key players when the time is right. Our immediate partnership priorities are BNC375 and our Kv1.3 programs, and BNC105 once data from the recently completed Phase II clinical trial is available in early 2014 calendar year. Looking ahead, future revenues are anticipated from payments received through our out-licensing arrangements with Ironwood and Merck, contract services fees earned by Neurofit as well as any further upfront or milestone payments that are secured by way of additional out-licensing arrangements secured for our other compounds. 6 LEVERAGING OUR CORE STRENGTHS INTO POwERfUL PARTNERSHIPS At Bionomics we have a simple business model: 3 Employ our proprietary drug discovery platforms to advance “first in class” and “best in class” drug compounds that target multi-billion dollar market opportunities in the pharmaceutical industry; 3 Identify partners with the development, regulatory and commercial capability to take our compounds to market; 3 Secure deals (sometimes in the pre-clinical phase) that will extract cash and deliver shareholder value early out of the portfolio – without compromising the commercial upside at the back end; and 3 Continuously look for new compounds and candidates that fit with our competitive strengths, and which allow us to diversify the portfolio and manage risk. DRUG DISCOVERY DRUG DEVELOPMENT PARTNERING » Platform for delivering new drug candidates » Propagates pipeline with multiple shots on goal » Targeted clinical trials » Lay off risk with experienced partners » Generate revenue streams to support discovery programs Our focussed partnership strategy around our drug candidates and platforms for drug discovery are key differentiators we see with Bionomics and some of our peers. According to Deloitte Trendlines, partnering has significant advantages with partnered compounds three times more likely to reach the market than those that are unpartnered. THE PARTNERSHIP EFFECT: SUCCESS RATES OF PARTNERED VS. UNPARTNERED COMPOUNDS Partnered compounds are three times more likely to reach the market than unpartnered compounds. Success rate is the percentage of compounds entering Phase I that reached Market in the US or EU. Data is for compounds that were in clinical development from 1/12/81 through 8/11/12 by 330 biopharmaceutical companies. A partnered compound is a compound that was part of a Co-Development, Collaboration, Co-Marketing, Co-Promotion, Development or Research License agreement, or a Joint Venture agreement that involved another biopharmaceutical company. The compound retains the status of partnered asset even though the partnership may have ended at some point. Our focus is on our key strengths across cancer, in particular solid tumour oncology, central nervous system and immune disease therapies. During the year we have made significant progress across each of these areas. 7 CEO & MANAGING DIRECTOR’S REPORT ONCOLOGY Both the human and socio-economic cost of solid tumours globally is substantial. According to the World Cancer Research Fund, there were an estimated 12.7 million cancer cases around the world in 2008, with this number expected to increase to 21 million by 2030. It is estimated that tens of billions are spent every year on the treatment of cancerous tumours. Bionomics is presently advancing five programs that target solid tumours that we believe will provide hope for patients suffering with the disease. Our most advanced compounds are BNC105 and BNC101 and these represent our key priorities. BNC105, VASCULAR DISRUPTING AGENT ENTERS kEY PHASE Renal cell carcinoma is believed to account for approximately 85 per cent of kidney cancers. Every year approximately 200,000 cases are diagnosed worldwide, with 55,000 people diagnosed in the US alone. The five year survival rate for patients with metastatic disease is less than 2 per cent. The cost of treating the disease is also significant with the market for drugs targeting renal cell carcinoma estimated at $2.5 billion per annum. In June, following presentation of the latest clinical data at ASCO, Bionomics announced that it had completed enrolment into a randomized Phase II clinical trial testing the combination of BNC105 plus everolimus (Afinitor) to treat patients with advanced renal cell carcinoma, the DisrupTOR-1 clinical trial. This is the first and only randomized trial to test the combination of an mTOR inhibitor (Afinitor) with a vascular disrupting agent (BNC105) in renal cancer. The enrolment of 139 patients (surpassing the target enrolment of 134 patients) into this first Phase II clinical trial of BNC105 was an important achievement for Bionomics. It is particularly exciting to reach this milestone in a trial which has the potential to create a new paradigm for the treatment of renal cancer. We have always said that we would be looking to partner this program once we had sufficient data from our clinical trials and achieving this milestone is an important step in the path to partnership. When the time is right, we hope to strike a strategic deal that will allow us to advance this compound through to market and deliver new hope to patients suffering from renal cancer. Treatment options remain limited in progressive metastatic renal cell cancer for patients who have failed tyrosine kinase inhibitor therapy and BNC105 has the potential to broaden treatment options for these patients. The mechanism of action of BNC105 provides an innovative approach to the treatment of solid tumours, including metastatic renal cell carcinoma, by attacking established tumour blood vessels. We believe that there is a strong scientific rationale for the combination of BNC105 and Afinitor, as well as compelling preclinical and Phase I data that support this approach. Afinitor and BNC105 work by different but complementary mechanisms of action. The vascular disrupting effect of BNC105 causes hypoxic stress and Afinitor concurrently blocks the mTOR driven recovery pathway of renal tumours. In pre-clinical trials BNC105 has demonstrated synergy in combination with Afinitor, causing significant tumour shrinkage. The Phase I component of the renal cancer trial has also provided encouragement. Phase I data is indicative of clinical benefit and sustained therapy, with patients staying on therapy for up to 18 months. The combination of BNC105 and Afinitor was found to be well tolerated with no dose limiting toxicities or evidence of cumulative toxicity. Eight of the 12 patients achieved disease stabilization. The median treatment period across these eight patients was 11 cycles with each treatment cycle being three weeks. Dose related changes in biomarkers indicative of vascular response suggest that BNC105 reaches effective plasma levels. As mentioned above, completing enrolment into the trial is an important step in the path to partnership. The data from this trial is anticipated early in calendar year 2014 and Bionomics, preferred position is to have a partner for BNC105 for Phase III trials. 8 BNC101, CANCER STEM CELL TARGETING ANTIBODY PREPARING fOR IND & PHASE I Cancer stem cell (CSC) targeting is widely viewed as the next significant advance in the treatment of cancer. Companies (US examples include Verastem, Oncomed and Stemline Therapeutics) pursuing this mode of action are increasingly gaining investor support and interest. The global market for CSC therapies is estimated to grow to US$8 billion per annum by 2016, with the market for cancer antibody therapies valued at in excess of US$20 billion in 2011. Bionomics has always sought to be at the cutting edge of cancer drug discovery. Given the importance of cancer stem cells in both cancer initiation and cancer recurrence it is an area that we want to lead. Not only are cancer stem cells important in cancer initiation and recurrence – they are also highly resistant to both chemo and radiation therapy. In September 2012, Bionomics announced that it had acquired Eclipse Therapeutics, a spin out from Biogen Idec (NADSAq: BIIB) for $10 million consideration in Bionomics shares, valued at $0.4176 cents per Bionomics share. The programs acquired through the transaction were the product of seven years of investment by Biogen Idec and included two antibody drug candidates we now refer to as BNC101 and BNC102. Since the acquisition we have initiated manufacturing and IND-enabling studies of BNC101 in preparation for clinical trial. At the same time we are compiling a strong data package on this humanized antibody and are presenting our data at key industry events such as the Molecular Med TriCon “Targeting Cancer Stem Cells” Meeting in San Francisco in February of this year and again at the 2013 PEGS “Promising New Targets – Oncology Stream” conference in Boston in May. These conferences provide Bionomics with the opportunity to highlight the promising work we are doing in cancer stem cell research. Preclinical studies have demonstrated that BNC101 significantly reduces CSC frequency and prevents tumour re-growth in long term studies. BNC101 increases survival and inhibits weight loss in a cachectic colorectal cancer tumour model. To date BNC101 has not shown evidence of toxicity in a preliminary safety analysis. We look forward to updating the market on our progress with a pre-IND submission for BNC101 before the end of the 2013 calendar year. The Eclipse acquisition has also provided Bionomics with an important strategic base in the US, the world’s largest pharmaceutical market, enhancing our ongoing business development activities – clearly an important element to the successful execution of our partnering strategy. BULK TUMOUR CELLS CANCER STEM CELLS CSC CONVENTIONAL CANCER THERAPY CANCER STEM CELL THERAPY TUMOUR RELAPSE TUMOUR REGRESSION 3 THE MISSING LINK IN TREATING SOLID TUMOURS 3 CSC’S ARE RESISTANT TO CONVENTIONAL THERAPIES 3 ERADICATING CSC’S MAY PREVENT RECURRENCE 3 COMPLEMENTS THE BNC105 PROGRAM BY TARGETING THE “SEEDS” OF CANCER 9 CEO & MANAGING DIRECTOR’S REPORT MILESTONE ACHIEVED IN COLLABORATION wITH THE CO-OPERATIVE RESEARCH CENTRE fOR CANCER THERAPEUTICS. In 2007 Bionomics joined a consortium of top Australian research centres to form the Co-operative Research Centre (CRC) for Cancer Therapeutics. The CRC for Cancer Therapeutics was awarded AU$37.69 million of federal government funding over seven years to develop new treatments for cancer. Bionomics has been the sole Australian commercial drug discovery partner of the CRC, which represents another side to our partnership model. On 16 May Bionomics announced the achievement of a milestone in one of the collaborative programs. A novel compound, CTx-0357927, suppressed cancer progression as indicated by tumour growth inhibition and number of identified metastases in an animal model of melanoma. CTx-0357927 is an inhibitor of vascular growth factor receptor 3 (VEGFR3), a receptor closely linked to the development of lymphatic vessels which act as a conduit for tumour cells spreading to different sites of the body. US figures suggest that the overall 5-year survival rate for patients whose melanoma is detected early, before the tumour has spread to the regional lymph nodes or other organs, is about 98 percent. The survival rate falls to 62 percent when the disease reaches the lymph nodes, and 15 percent when the disease metastasizes to distant organs. Melanoma is the fourth most common cancer reported in Australia. In 2008, there were 11,057 new cases of melanoma of the skin in Australia accounting for 9.8 per cent of all new cancers. Foreground: Annabell Leske, Research Associate Drug Development Background from left: Chloe Brown, Laboratory Technician, Dr Daniel Inglis, Research Scientist 10 Foreground: Carolyn Coles, Project Manager Neuroscience Background: Dr Jorgen Mould, Director, Ion Channel Biology & Head, ionX Platform Development CENTRAL NERVOUS SYSTEM The market for drugs treating central nervous system (CNS) diseases is significant and growing. In the US, anxiety disorders affect 40 million people each year and while there are therapies available there remains a significant, unmet need. Global sales for anti-anxiety drugs alone are estimated to be in excess of US$5 billion per annum and global sales of drugs that treat depression are more than twice that. At the same time, more than five million Americans are living with Alzheimer’s which is estimated to cost that nation in excess of US$200 billion per annum. Alzheimer’s is now the sixth leading cause of death in the US. In CNS, Bionomics has developed a very solid portfolio of drug candidates which include anti-anxiety compound IW-2143 (BNC210) out-licensed last year to Ironwood Pharmaceuticals (NASDAq: IRWD) and BNC375 a compound targeting treatment for Alzheimer’s and other related CNS conditions. With the recently announced partnership with Merck on our pain program, the validation of Bionomics’ CNS capability is achieving global recognition. UPDATE ON IRONwOOD PARTNERSHIP In December 2012 Bionomics was advised by its licensee Ironwood Pharmaceuticals Inc. that a Phase I clinical trial of the investigational anti-anxiety drug candidate IW-2143 (BNC210) had commenced in the US, following the November 2012 submission of an IND application to the US FDA. The Phase I program is designed to assess the safety and pharmacokinetics of IW-2143 in healthy volunteers, using single and multi-dose administration. This is the first US clinical trial of IW-2143 and Ironwood is responsible for developing and, if approved, commercialising IW-2143 and related compounds, including paying for the costs of clinical development. A US$2 million milestone payment to Bionomics by Ironwood could be triggered through progression of the Phase I program. Pending achievement of certain development and regulatory milestones, Bionomics could receive up to US$345 million in upfront and milestone payments and research funding, as well as royalties on sales of products incorporating BNC210 and other related compounds. 11 CEO & MANAGING DIRECTOR’S REPORT DUAL TRACk STRATEGY TO MAxIMIzE VALUE fROM ALzHEIMER’S COMPOUND Bionomics announced in December 2012 that it had identified a novel compound with promising properties as a potential new treatment for Alzheimer’s disease. Following validation in preclinical models of memory deficit in Alzheimer’s, Bionomics formally nominated BNC375 as its drug candidate. BNC375 is proprietary to Bionomics and employs a mode of action that is showing great promise in the clinic. BNC375 is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. This receptor has been identified as an important target for improvement of memory and learning deficits that occur in Alzheimer’s disease, Parkinson’s disease and many other conditions. BNC375 has been found to be effective across a panel of animal models of impaired learning and memory. To date it has shown no signs of side effects. Recognising the potential for value creation through partnership for this compound, Bionomics raised an additional $16.4 million earlier this year to allow it to pursue a dual track strategy for BNC375. Raising the additional capital ensured the business had a strong balance sheet to enable it to advance the program and to negotiate a major partnership deal. BNC375: COMPETITIVE ADVANTAGES * * Based on data from preclinical animal studies + Published information and Bionomics’ in-house data characteristicsbionomics bnc375comPetinG aGents +PotentüüRapid onset of actionüûPotentiates endogenous receptor ligandüûPreserve the normal signalling patterns of the receptorüûDo not cause receptor desensitizationüûNo potential for development of toleranceüûSelectivity over other nicotinic receptorsüü 12 PAIN PARTNERSHIP wITH MERCk VALIDATES TECHNOLOGY PLATfORMS In a significant development post 30 June 2013, Bionomics has formed a partnership with Merck & Co to discover and develop novel small molecule candidates for the treatment of chronic pain, including neuropathic pain. The initial period of the research program will be two years. Through partnerships such as this Bionomics is continuing to deliver on its business model of strategic partnering for the development and commercialisation of selected programs within its pipeline. Bionomics is using its ionX® drug discovery platform and MultiCore® chemistry to identify potential drug candidates. This research collaboration is thus a strong validation of our drug discovery platforms. As shareholders are aware Bionomics targets very significant market opportunities in each of its drug discovery programs and the pain market is no exception. The global pain treatment market recorded sales of US$22 billion in 2010. However, as patent expiries loom, the global market value is anticipated by some analysts to contract to US$18.7 billion by 2016. Within the global pain market the neuropathic pain market is expected to grow from US$2.4 billion in 2010 to reach US$3.6 billion by 2020. (The Pain Outlook to 2013, Scrip Business Insights 2011). Bionomics also targets areas where patient’s needs may not be adequately addressed. For example current medications used to treat neuropathic pain have limited effectiveness and it has been estimated that only one in four patients with neuropathic pain achieve greater than 50% reduction in pain levels. Side-effects of current medications include drowsiness, somnolence and dizziness. US $172M PAIN PARTNERSHIP wITH MERCk & CO Deal further validates ionX® & MultiCore® drug discovery platforms Value creation through strategic partnering business model 13 CEO & MANAGING DIRECTOR’S REPORT Dr Anton Grishin, Senior Research Scientist IMMUNE DISEASE The global market for immunomodulator drugs is estimated at US$46.8 billion. Immunomodulators have the potential to provide effective therapies for a range of inflammatory indications such as multiple sclerosis, rheumatoid arthritis, psoriasis and uveitis. With few therapeutic options for these conditions, the commercial opportunity for companies that have effective treatments for these conditions is substantial. Bionomics Kv1.3 program has enormous potential in the treatment of immune-related conditions. Since regaining ownership of the Kv1.3 program from Merck Serono, Bionomics has continued to advance this program, building out the data package and positioning the business to secure another development and commercial partner. Partnership discussions are ongoing with a number of companies at this time. OUTLOOk I believe the next twelve months will be a watershed period for the Company as we await the BNC105 clinical trial results which will position this program for a strategic partnership. With a very valuable pipeline of compounds that leverage our core strengths in solid tumour oncology and central nervous system therapies we are nearing further key inflection points for the business as we seek to put additional partnerships in place. We believe our strategy to partner our programs will continue to provide us with industry validation for our compounds, crystallizing the value of our portfolio and enabling us to secure multiple recurrent revenue streams from our intellectual property over time. Of course the recent evidence for this comes from our partnership with Merck on our pain program. We are excited about the coming year and look forward to updating you on our progress. I would like to extend my thanks to our Board, the Bionomics team and most of all our shareholders for their continued support. Yours sincerely, Deborah Rathjen CEO & Managing Director 14 DISCOVERY PRECLINICAL PHASE I PHASE II LICENSEE / PARTNER DRUG CANDIDATE / PROGRAM CANCER BNC105 SOLID TUMOURS, RENAL, OVARIAN, MESOTHELIOMA BNC101 CANCER STEM CELLS, SOLID TUMOURS, COLON, BREAST, PANCREATIC BNC102 CANCER STEM CELLS, SOLID TUMOURS VEGFR3 SOLID TUMOURS, MELANOMA, BREAST RET LUNG AND THYROID CANCERS CENTRAL NERVOUS SYSTEM BNC210 (IW-2143) ANXIETY/DEPRESSION BNC375 COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, ADHD, SCHIZOPHRENIA GABA-A EPILEPSY UNDISCLOSED PAIN IMMUNE DISEASE Kv1.3 PSORIASIS, MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS PIPELINE 15 INTELLECTUAL PROPERTY PORTFOLIO Bionomics continues to build a strong patent portfolio covering the key elements of its business. Through the worldwide Patent Cooperation Treaty (PCT) mechanism, Bionomics and its related companies were granted 19 patents this financial year, 21 PCT patent applications entered the national and regional phases of examination and 9 provisional patent applications were filed as indicated below. NEW PATENT APPLICATIONS GRANTED THIS FINANCIAL YEAR: GRANTED PATENT NO. COUNTRY TITLE 8217189 United States of America Novel chromenone potassium channel blockers and uses thereof GRANT DATE 10 July 2012 575685 New Zealand Novel benzofuran potassium channel blockers and uses thereof 6 August 2012 2454073 Canada Mutations in ion channels 28 August 2012 2008307075 Australia Novel aryl potassium channel blockers and uses thereof 30 August 2012 160125 Singapore Novel benzofuran potassium channel blockers and uses thereof 31 August 2012 8278290 8288096 8293737 8309351 8309545 United States of America United States of America United States of America United States of America Novel tubulin polymerisation inhibitors 2 October 2012 Diagnostic method for epilepsy Novel anxiolytic compounds 16 October 2012 23 October 2012 Markers of endothelial cells and uses thereof 13 November 2012 United States of America Novel benzofuran potassium channel blockers and uses thereof 13 November 2012 2074123 Europe Novel anxiolytic compounds 5 December 2012 589989 New Zealand Novel potassium channel blockers and uses thereof 11 December 2012 HK1124329 Hong Kong Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymeristaion inhibitors 4 January 2013 2007304880 Australia Novel benzofuran potassium channel blockers and user thereof 24 January 2013 2431891 Canada Sodium-channel alpha1-subunit and their polypeptides and their treatment of generalised epilepsy with febrile seizures plus 29 January 2013 2007332143 Australia Chemical compounds and processes 21 February 2013 16 GRANTED PATENT NO. COUNTRY TITLE HK1132268 Hong Kong Novel anxiolytic compounds GRANT DATE 3 May 2013 584330 New Zealand Markers of endothelial cells and uses thereof 30 April 2013 2007304881 Australia Novel chromenone potassium channel blockers and uses thereof 25 June 2013 NEW PATENT APPLICATIONS FILED THIS FINANCIAL YEAR: FILED PATENT NO. COUNTRIES TITLE 2012903296 Provisional 2012903295 Provisional α7 Nicotinic acetylcholine receptor modulators and uses thereof-I α7 Nicotinic acetylcholine receptor modulators and uses thereof-II 13/617317 13/617153 Provisional Novel anxiolytic compounds (Cont 1) Provisional Novel anxiolytic compounds (Cont 2) 61/696511 Provisional Compounds and methods for treating a disease or condition 12186384.9 Europe Novel anxiolytic compounds 12113140.8 Hong Kong Combination therapy for treating proliferative diseases 12113139.1 Hong Kong Treatment for macular degeneration PROGRAM α7 nAChR α7 nAChR Anxiety Anxiety Anxiety Anxiety BNC105 BNC105 2013900167 Provisional α7 Nicotinic acetylcholine receptor modulators and uses thereof α7 nAChR 2805397 Canada 201180042879.0 China 463/DELNP/2013 India 2013:518910 Japan Chemical processes for the manufacture of substituted benzofurans Chemical processes for the manufacture of substituted benzofurans Chemical processes for the manufacture of substituted benzofurans Chemical processes for the manufacture of substituted benzofurans 13/810364 United States of America Chemical processes for the manufacture of substituted benzofurans 11806154.8 Europe 605923 New Zealand Chemical processes for the manufacture of substituted benzofurans Chemical processes for the manufacture of substituted benzofurans BNC105 BNC105 BNC105 BNC105 BNC105 BNC105 BNC105 17 INTELLECTUAL PROPERTY PORTFOLIO FILED PATENT NO. COUNTRIES TITLE PROGRAM 2011279560 Australia Chemical processes for the manufacture of substituted benzofurans 61/798926 61/787436 United States Provisional Salts, co-crystals and polymers of an anxiolytic compound United States Provisional Polymorph B of an anxiolytic compound PCT/AU2013/000497 PCT Polymorph B of an anxiolytic compound 2013204159 Australia Polymorph B of an anxiolytic compound 2013202426 Australia Divisional Novel anxiolytic compounds 2012222874 Australia Novel small-molecules as therapeutics 2012222869 Australia Methods of treating a disease or condition of the central nervous system 2012253237 Australia Methods for preparing naphthyridines 2013901443 Provisional 2013-531697 Japan Divisional 2012212393 Australia PCT/AU2013/000581 PCT 2013204313 Australia α 7 Nicotinic acetylcholine receptor modulators and uses thereof III Novel anxiolytic compounds Positive allosteric modulators of the alpha 7 nicotinic acetycholine receptor and uses thereof Combination therapy involving a vascular disrupting agent and an agent which targets hypoxia Combination therapy involving a vascular disrupting agent and an agent which targets hypoxia 2012255690 Australia Amine derivatives as potassium channel blockers BNC105 BNC210 BNC210 BNC210 BNC210 Anxiety Anxiety Anxiety Anxiety α7 nAChR Anxiety α7 nAChR BNC105 BNC105 Kv1.3 Overview Of patent pOrtfOliO8 patent applications covering BNC105, related molecules and biomarkers7 patent applications covering BNC210 and its use in the treatment of anxiety and other disorders 8 patent applications covering molecules which inhibit the activity of the Kv1.3 ion channel and the use of these molecules in the treatment of Multiple Sclerosis and other autoimmune disorders2 patent applications covering Parkinson’s Disease and related disorders4 patent applications covering memory enhancement and related disorders5 patent applications covering cancer stem cells and related disorders21 pending patent applications covering discoveries made utilizing Bionomics’ technology platforms 18 BOARD OF DIRECTORS MR GRAEME kAUfMAN BSC, MBA CHAIRMAN, NON-ExECUTIVE DIRECTOR Mr Kaufman has wide ranging experience across the biotechnology sector, spanning scientific, commercial and financial areas. His experience with CSL Limited, Australia’s largest biopharmaceutical company included responsibility for all of their manufacturing facilities, and the operation of an independent business division operating in the high technology medical device market. As CSL’s General Manager Finance, Mr Kaufman had global responsibility for finance, strategy development, human resources and information technology. Mr Kaufman has also served as an executive director of ASX-listed Circadian Technologies and a non-executive director of Amrad Corporation. He was previously Executive Vice President Corporate Finance with Mesoblast Limited and is currently a non-executive director of IDT Australia Limited and Cellmid Limited. DR DEBORAH RATHjEN BSC (HONS), PHD, MAICD, fTSE CEO AND MANAGING DIRECTOR A seasoned biotech executive of almost 20 years, Dr Deborah Rathjen joined Bionomics in June 2000 from Peptech Limited, where she was Manager of Business Development and Licensing. Dr Rathjen was a co-inventor of Peptech’s TNF technology and leader of the company’s successful defence of its key TNF patents against a legal challenge by BASF, providing Peptech with a strong commercial basis for licensing negotiations with BASF, Centocor and other companies with anti-TNF products. Dr Rathjen has significant experience in company building and financing, mergers and acquisitions, therapeutic product research and development, and business development and licensing. Dr Rathjen is Chairperson of the AusBiotech Board and in 2004 was awarded the AusBiotech President’s Medal for her significant contribution to the Australian biotechnology industry. In 2006 she received a Distinguished Alumni Award from Flinders University, in 2009 the BioSingapore Asia Pacific Woman Entrepreneur of the Year, 2010 Bio Innovation SA Industry Leader Award and the BioSpectum Asia person of the year 2013. 19 BOARD OF DIRECTORS MR TREVOR TAPPENDEN ACA, fAICD NON-ExECUTIVE DIRECTOR Mr Tappenden commenced a career as a Non-Executive Director in 2003 after a career with Ernst & Young spanning 30 years. During his time at Ernst & Young Mr Tappenden held a variety of positions including Managing Partner of the Melbourne Office, member of the Board of Partners, Head of the Victorian Government Services Group and National Director of the Entrepreneurial Services Division. He holds directorships in various private, government and not-for-profit organisations and is the Chairman of the Audit and Risk Management Committees of many of those organisations. . DR ERROL DE SOUzA PHD NON-ExECUTIVE DIRECTOR Dr De Souza is a leader in the development of therapeutics for treatment of central nervous system (CNS) disorders. He is currently President and CEO of a leading US company Biodel Inc (Nasdaq: BIOD) and is the former President and CEO of US biotech companies Archemix Corporation and Synaptic Pharmaceutical Corporation. Dr De Souza formerly held senior management positions at Aventis and its predecessor Hoechst Marion Roussel Pharmaceuticals, Inc. Most recently, he was Senior Vice President and Site Head of US Drug Innovation and Approval (R&D), at Aventis, where he was responsible for the discovery and development of drug candidates through Phase IIa clinical trials for CNS and inflammatory disorders. Prior to Aventis, he was a co-founder and Chief Scientific Officer of Neurocrine Biosciences (Nasdaq: NBIX). Dr De Souza has served on multiple editorial boards, National Institutes of Health (NIH) Committees and is currently a Director of several public and private companies. DR jONATHAN LIM MD NON-ExECUTIVE DIRECTOR Jonathan Lim, MD is Managing Partner of City Hill Ventures, LLC, which he established in 2010 prior to co- founding Eclipse Therapeutics in early 2011. Dr Lim was formerly President, CEO, and Board Director of Halozyme Therapeutics, Inc. where he grew the company from five employees and a market value of $5 million in May 2003 to 140 employees and peak market capitalisation of nearly $1 billion during his tenure. Under Dr Lim’s eight years of leadership, the company went public and raised $300 million from financing and corporate partnerships with Roche and Baxter, achieved two US FDA approvals, and built a late stage pipeline of two Phase III, two Phase II, and two Phase I product candidates. Dr Lim’s prior experience includes management consulting at McKinsey, NIH Postdoctoral Fellowship at Harvard, and general surgery residency at New York Hospital-Cornell. He has BS and MS degrees from Stanford, MD from McGill and MPH from Harvard. 20 MANAGEMENT DR jOSÉ IGLESIAS MD CHIEf MEDICAL OffICER Dr Iglesias, responsible for clinical development of the Bionomics Oncology pipeline and with Bionomics since November 2012, is a seasoned medical professional with 22 years global experience in the biopharmaceutical industry. Prior to joining Bionomics, he spent six years at Celgene Corporation and its wholly owned subsidiary Abraxis Bioscience as VP of Clinical Development at Celgene with previous roles including CMO and VP of Global Clinical Development and Medical Affairs at Abraxis. Previously, Dr Iglesias worked in several positions at US pharmaceutical giant Eli Lilly over 10 years, including his appointment as Oncology Medical Advisor for the Australia and the Asia Pacific region between 2002 and 2004. A graduate from the Montevideo School of Medicine, Dr Iglesias has been published more than 50 times and is an active member of ASCO, AACR and ESMO. MS MELANIE YOUNG BCOM, CA CHIEf fINANCIAL OffICER AND COMPANY SECRETARY Ms Young has over 14 year’s experience, with six years in the medical device field, including two years as CFO of an ASX-listed company covering all facets of the company’s global finance function. In particular, her considerable commercial experience in listed company reporting requirements, international finances and working capital management complements the Bionomics team. Ms Young has also gained experience in negotiating distributor agreements, due diligence, cost reduction strategies and improving operating efficiencies. Previously Ms Young worked for Deloitte Touche Tohmatsu in the Growth Solutions Division. Ms Young holds a Bachelor of Commerce from Deakin University and is a Chartered Accountant. 21 CORPORATE GOVERNANCE STATEMENT Bionomics Limited (the Company) and the Board are committed to achieving and applying a high standard of corporate governance taking into consideration the Company’s size and the industry in which the Company operates. The Company’s Governance framework is consistent with the Australian Securities Exchange (ASX) Corporate Governance Council (ASX CGC) guidelines. The relationship and division of responsibilities between the Board and other key management personnel is critical to the Company’s long-term success. The directors are responsible to the shareholders for the performance of the Company in both the short and the longer term and for seeking an appropriate balance between sometimes competing objectives in determining the best interests of the Company. Their focus is to enhance the interests of shareholders and to ensure the Company is properly governed. Day to day management of the Company’s affairs, including the implementation of its approved strategy and policy initiatives, is delegated by the Board to the Chief Executive Officer and Managing Director and other key management personnel, except for matters expressly required by law to be approved by the Board. This delegation process has been formalised by the documentation of responsibilities between the Chairman and the Chief Executive Officer and Managing Director and incorporated into the Board’s charter. The following corporate governance framework has been implemented to ensure the highest level of corporate governance is achieved: 3 establishment of an internal control framework focusing on key business risks; 3 adoption of a code of professional ethics and conduct which applies to all directors, officers and employees; 3 implementation of strict policies regarding related party transactions and the acquisition and disposal of the Company’s securities by directors, officers and employees; and 3 adoption of clear reporting and communication policies and procedures. A description of the Company’s main corporate governance practices is set out over. All these practices, unless otherwise stated, were in place for the entire year. THE BOARD OF DIRECTORS The Board of Directors (the Board) operates in accordance with the broad principles formally set out in its charter (Board Charter) that is available from the corporate governance section of the Company website at www.bionomics.com.au. The Board Charter details the Board’s composition and responsibilities. The Board Charter (inter alia) states: 3 the Bionomics’ Board will at all times recognise its overriding responsibility to act honestly, fairly, diligently and in accordance with the law in fulfilling its primary responsibility of looking after the interests of Bionomics’ shareholders. These interests are well served by also taking into consideration the interests of other stakeholders such as employees and affiliated institutions. 3 the Board is to be comprised of both executive and non- executive directors with a majority of non-executive directors. 3 in recognition of the importance of independent views and the Board’s role in supervising the activities of management, the majority of the Board must be independent of management and all directors are required to bring independent judgement to bear in their Board decision making. 3 the Board shall undertake an annual Board performance evaluation to identify any improvements necessary for both its operations and the Board Charter. RESpOnSiBiLiTiES Of ThE BOARD The responsibilities of the Board include: 3 approving the strategic direction, objectives and annual financial budget of Bionomics and monitoring the implementation of those strategies and achievement of those objectives and budget. 3 monitoring compliance with regulatory requirements and ethical standards. 3 appointing and reviewing the performance of the Chief Executive Officer and Managing Director and of the performance of the Chief Executive Officer’s direct reports in achieving corporate goals. 3 approving announcements to shareholders and the ASX. 3 approving significant third party agreements. 3 issuing shares, options, equity instruments or other securities. 3 developing Bionomics’ corporate governance procedures, systems of risk management and internal compliance and control, codes of conduct (including human resources policies) and legal compliance. 22 3 approving and monitoring the progress of major capital expenditure, capital management and acquisitions and divestures. 3 assessing the composition of the Board and reviewing its processes and performance. BOARD MEMBERS Details of the members of the Board, their experience, expertise, qualifications, term of office and independence status are set out in the Directors’ Report under the heading ‘information on Directors’. At the date of signing the Directors’ Report there were four non-executive directors (including the Chairman), all of whom are deemed independent under the principles set out below and one executive director. The Board seeks to ensure that it is cognisant of the state of development of Bionomics as a company: 3 at any point in time, its membership as a group has expertise in areas of current and future importance to the Company as it grows. 3 the size of the Board is conducive to effective discussion and efficient decision-making. DiRECTORS’ inDEpEnDEnCE The Board has adopted specific principles in relation to directors’ independence. These state that to be deemed independent, a director must be independent of management and free of any business or other relationship that could materially interfere with – or could reasonably be perceived to materially interfere with – the exercise of their unfettered and independent judgement. issues relating to an assessment of the independence of a director will be determined by reference to the guidance provided by the ASX CGC guidelines. The Board shall determine the thresholds of materiality from the perspective of both the Company and its directors in determining whether a director maintains his or her independence of mind. TERM Of OffiCE The Company’s Constitution specifies that all non-executive directors must retire from office no later than the third AGM following their last election, however they may offer themselves for re-election. ROLE Of ThE ChAiRMAn AnD ChiEf EXECuTivE OffiCER AnD MAnAGinG DiRECTOR The Chairman is responsible for leading the Board, ensuring directors are properly briefed in all matters relevant to their role and responsibilities, facilitating Board discussions and managing the Board’s relationship with the Company’s key management personnel. The Chief Executive Officer and Managing Director is responsible for implementing the Company strategies and policies. COMMiTMEnT Regular Board meetings and reviews of strategy are held throughout the year to monitor performance against both the Board approved objectives and the Board’s broad strategic plan. The number of meetings of the Company’s Board and of each Board committee held during the year ended 30 June 2013 and the number of meetings attended by each director is disclosed in the Directors’ Report under the heading ‘Meetings of Directors’. it is the Company’s practice to allow its executive director to accept appointments outside the Company with prior written approval of the Board. COnfLiCT Of inTERESTS All Board members are required as a continuing obligation to immediately notify the Board in writing of any actual or potential conflicts of interest or any circumstance that may affect a Board member’s level of independence. inDEpEnDEnT pROfESSiOnAL ADviCE Directors may seek independent professional advice, at the expense of the Company, on any matter connected with the discharge of their responsibilities. prior written approval of the Chairman is required, but this will not be unreasonably withheld. Copies of this advice will be made available to, and for the benefit of, all Board members at the discretion of the Chairman. pERfORMAnCE ASSESSMEnT in line with the timetables setting out the adoption of the ASX CGC guidelines the Board undertakes an annual self-assessment comparing its performance with the requirements of the Board Charter. in this process, the Chairman meets directors individually to assess how Board performance may be improved. 23 CORPORATE GOVERNANCE STATEMENT DivERSiTY Bionomics has implemented a diversity policy. While the key focus of the Diversity policy and the ASX Corporate Governance Council’s recommendations is on promoting the role of women within organisations, the Company recognises that other forms of diversity are also important and seeks to promote and facilitate a range of diversity initiatives throughout the Company beyond gender diversity including setting measurable objectives as necessary. The Board will ensure that appropriate procedures and measures are introduced and delegated to the Audit and Risk Management Committee to ensure that the Company’s diversity commitments are implemented appropriately. With an extremely limited pool of appropriate candidates for many roles throughout the organisation, the Company considers that it would be detrimental to shareholder interest to recruit on any basis other than merit, as such no measurable objectives have been established at this time. Recommendation 3.4 of the principles of ASX listing rules (Guidance note 9) requires ASX listed entities to disclose in the Annual Report the proportion of women in the whole organisation, in senior executive positions and on the Board at the end of year. TOTAL BOARD SENIOR EXECUTIVE OTHER All Staff female Staff 59 28 5 1 2 1 52 26 % of total 47% 20% 50% 50% CORPORATE REPORTING for each of the half-year and full-year results, the Chief Executive Officer and Managing Director and Chief financial Officer are required to make the following certifications to the Board: 3 that the Company’s financial statements are complete and present a true and fair view, in all material respects, of the financial condition and operational results of the Company and are in accordance with relevant accounting standards; and 3 that the above statement is founded on a sound system of risk management and internal compliance and control which implements the policies adopted by the Board and that the Company’s risk management and internal compliance and control are operating efficiently and effectively in all material respects. BOARD COMMITTEES The Board has established one committee to assist in the execution of its duties and to allow detailed consideration of complex issues. This committee is the Audit and Risk Management Committee, which is comprised entirely of non- executive directors. All matters determined by the committee are submitted to the full Board as recommendations for final Board decision. Minutes of committee meetings are tabled at a subsequent Board meeting. There is no formal nomination committee for the Company. nominations for the Board are considered by the full Board as part of normal business reviewed by the Board at its regular meetings. under the Board Charter, in the event that the Board believes a new director should be appointed, the Board shall review the range of skills, experience and expertise currently existing on the Board in relation to areas of current and future importance to the Company as it grows. Candidates are assessed against this review of needs and, where appropriate, advice is sought from independent search consultants. Where the Board appoints a suitable candidate that person must stand for election at the next AGM of the Company. notices of meeting for the election of directors comply with the ASX CGC guidelines. new directors will be provided with a letter of appointment setting out the Company’s expectations, their responsibilities, rights and the terms and conditions of their appointment. COMpEnSATiOn COMMiTTEE Due to the size of the Board, all Compensation Committee functions are handled by the full Board rather than a subcommittee. in this context, the Board decides on remuneration and incentive policies and practices generally and makes specific recommendations on remuneration packages and other terms of employment for executive directors and non- executive directors. All key management personnel sign a formal employment contract at the time of their appointment covering a range of matters including their duties, rights, responsibilities and any entitlements on termination. A formal establishment of annual objectives and subsequent evaluation of performance including a half-year review is conducted by the Chief Executive Officer and Managing Director with all key management personnel who report directly to that position. 24 further information on directors’ and other key management personnel’s remuneration is set out in the Directors’ Report and note 23 to the financial statements. The Compensation Committee previously had responsibility for reviewing any transactions between the Company and the directors, or any interest associated with the directors, to ensure the structure and the terms of the transaction was in compliance with the Corporations Act 2001 and was appropriately disclosed. This is now the responsibility of the full Board. AuDiT AnD RiSk MAnAGEMEnT COMMiTTEE The Audit and Risk Management Committee consists of the following non-executive directors: 3 Mr Trevor Tappenden (Chairman) 3 Mr Graeme kaufman (appointed 18 September 2012) 3 Mr Christopher fullerton (retired 31 December 2012) Details of the directors’ qualifications and all attendance at Audit and Risk Management Committee meetings are set out in the Directors’ Report. The Audit and Risk Management Committee has its own charter setting out its role and responsibilities, composition, structure, membership requirements and the manner in which the Committee is to operate. This charter is available on the Company website. The main responsibilities of the Committee are to: 3 review, assess and recommend the annual and half-year financial statements to the Board; and 3 assist the Board in fulfilling its oversight responsibilities through reviewing: 3 the financial reporting process; 3 the system of internal control and management of risks; 3 the audit process; and 3 the Company’s process for monitoring compliance with laws and regulations. included in these responsibilities, the Audit and Risk Management Committee: 3 reviews the external auditors’ proposed audit scope, approach and their performance; 3 makes recommendations to the Board regarding the re-appointment of the external auditors; 3 considers the independence of the external auditors including the range of non-audit related services provided by the external auditors to the Company; and 3 ensures the Company establishes an effective Risk Management policy and ensures compliance. in fulfilling its responsibilities, the Audit and Risk Management Committee: 3 receives regular reports from management and external auditors; 3 reviews whether management is adopting systems and processes sufficient for a company of Bionomics’ size and stage of development; 3 reviews any significant disagreements between the external auditors and management, irrespective of whether they have been resolved; 3 meets separately with external auditors at least twice a year without the presence of management; and 3 provides external auditors with a clear line of direct communication at any time to either the Chairman of the Audit and Risk Management Committee or the Chairman of the Board. The Audit and Risk Management Committee has authority, within the scope of its responsibilities, to seek any information it requires from any employee or external party and to obtain external legal or other professional advice. EXTERNAL AUDITORS The Board’s policy is to appoint external auditors who clearly demonstrate quality and independence. The performance of the external auditor is reviewed annually by the Audit and Risk Management Committee which also makes recommendations to the Board about the appointment of audit services for subsequent periods, taking into consideration assessment of performance, existing value and costs. Deloitte Touche Tohmatsu were appointed as external auditor in 2007. Deloitte’s policy is to rotate engagement partners every five years in line with the requirements of the Corporations Act 2001. An analysis of fees paid to the external auditors, including a breakdown of fees for non-audit services, is provided in note 26 to the financial statements. it is the policy of the external auditors to provide an annual declaration of their independence to both the Audit and Risk Management Committee and the Board. The external auditor is requested to attend the Annual General Meeting (AGM) and be available to answer shareholder questions about the conduct of the audit and the preparation and content of the audit report. 25 CORPORATE GOVERNANCE STATEMENT RISK ASSESSMENT AND RISK MANAGEMENT The Board, through the Audit and Risk Management Committee, is responsible for ensuring there are adequate policies in relation to risk management, compliance and internal control systems. in summary, Company policies are designed to ensure significant strategic, operational, legal, reputational and financial risks are identified, assessed and effectively monitored and managed in a manner sufficient for a company of Bionomics’ size and stage of development to enable achievement of the Company’s business strategy and objectives. The Company’s risk management policies are managed by the key management personnel and other senior staff. The policies are reviewed by the Audit and Risk Management Committee according to a timetable of assessment and review proposed by that Committee and approved by the Board. ENVIRONMENTAL, WORK HEALTH AND SAFETY MANAGEMENT POLICIES The Company recognises the importance of work health and safety (WhS) and is committed to the highest levels of performance. To help meet this objective, policies have been established to facilitate the systematic identification of WhS issues and to ensure they are managed in a structured manner. This system allows the Company to: 3 monitor its compliance with all relevant legislation; and 3 encourage employees to actively participate in the management of WhS issues. The Company is in full compliance with all necessary environmental and other licensing requirements required for its research facilities in Thebarton (South Australia), San Diego (Bionomics inc) and for neurofit SAS (neurofit) in france. CODE OF CONDUCT in its Board Charter, the Board has recognised its overriding responsibility to act honestly, fairly, diligently and in accordance with the law in fulfilling its primary responsibility of looking after the interests of Bionomics’ shareholders. The Board believes that the interests of shareholders are best served by also taking into account the interests of other stakeholders such as Bionomics’ employees and individuals engaged in Bionomics’ directed research at Bionomics’ affiliated institutions. The Board will work to promote and maintain an environment within Bionomics that establishes these principles as basic guidelines for all employees. Bionomics has formalised a code of business conduct and ethics. A number of policies that relate to business conduct are in place including harassment prevention and share trading, with training provided to all employees as new policies are implemented. Copies of the share trading policies for directors and employees are available on the Company’s website. CONTINUOUS DISCLOSURE AND SHAREHOLDER COMMUNICATION The Company has written policies and procedures that focus on continuous disclosure of any information concerning the Company that a reasonable person would expect to have a material effect on the price of the Company’s securities. These policies and procedures also include the arrangements the Company has in place to promote communication with shareholders and encourage effective participation at AGMs. These policies and procedures are available on the Company’s website. The Chief Executive Officer and Managing Director has been nominated as the person responsible for communications with the ASX. This role includes responsibility for ensuring compliance with the continuous disclosure requirements in the ASX Listing Rules and overseeing and co-ordinating information disclosure to the ASX, analysts, brokers, shareholders, the media and the public. All announcements disclosed to the ASX are posted on the Company’s website as soon as practical after disclosure to the ASX. procedures have also been established for reviewing whether any price sensitive information has been inadvertently disclosed, and if so, this information is also immediately released to the market. All shareholders are entitled to receive a copy of the Company’s Annual Report. in addition, the Company seeks to provide opportunities for shareholders to participate through electronic means. initiatives to facilitate this include making all Company announcements, details of Company meetings, press releases for the last three years and financial statements available on the Company’s website along with transcripts of the Chairman’s and Chief Executive Officer and Managing Director’s addresses to the Company’s AGMs. The website also includes a feedback and information request mechanism for investors and shareholders via the Contact us page of the website. AUSTRALIAN EQUIVALENTS TO INTERNATIONAL FINANCIAL REPORTING STANDARDS (AIFRS) The financial statements are prepared in accordance with AifRS. 26 DIRECTORS’ REPORT Your directors present their report on the financial statements of the Group for the year ended 30 June 2013, comprising the parent entity Bionomics Limited (Bionomics) and its subsidiaries. in order to comply with the Corporations Act 2001, the directors report as follows: DiRECTORS The following persons were directors of Bionomics during the period and up to the date of this report: The consolidated Group’s Statement of financial position was strengthened by the non-Renounceable Rights issue in April 2013 raising a net cash inflow of $15.6m. The cash position at 30 June 2013 was $22,452,089 (2012: $17,336,609). The financial performance of key operating segments of Drug discovery, Drug development and Contract services are included in note 3. 3 Mr Graeme kaufman, non-Executive Chairman (appointed 18 September 2012) 3 Dr Deborah Rathjen, Chief Executive Officer and Managing Director 3 Mr Trevor Tappenden, non-Executive Director 3 Dr Errol De Souza, non-Executive Director 3 Dr Jonathan Lim, non-Executive Director (appointed 14 September 2012) 3 Mr Christopher fullerton (retired 31 December 2012) The directors held office during the whole of the financial year and since the end of the financial year unless otherwise indicated. pRinCipAL ACTiviTiES The principal activities of the Group during the period were: 3 to undertake research and development utilising Bionomics’ proprietary technology platforms with the aim of identifying and developing therapies to treat cancer and conditions of the Central nervous System (CnS), including anxiety, Multiple Sclerosis and epilepsy; 3 to commercialise intellectual property assets; and 3 to identify strategic alliances and project opportunities capable of increasing shareholder value and of enhancing the competitive advantage of Bionomics within the biotechnology industry. OpERATinG RESuLTS Consolidated revenue for the year to 30 June 2013 decreased by 46% to $3,724,169, predominately attributable to the timing of ironwood pharmaceuticals revenue (collaboration and milestones) for commercialising BnC210 after licensing in January 2012. Grant funding and government assistance for the period was $8,101,787 relating to the Research and Development (R&D) Tax incentive introduced from 1 July 2011. This compared with revenues of $6,834,709 and grant funding of $3,102,837 for the year to 30 June 2012. The operating loss after tax of the Group for the year to 30 June 2013 was $10,001,350 compared with the prior year after tax loss of $3,136,238. The acquisition of Eclipse Therapeutics, inc in September 2012 contributed to the increase in intangible assets and the associated contingent consideration liability estimated in the Statement of financial position and detailed in note 32. REviEW Of OpERATiOnS Bionomics’ business model involves: 3 employing our proprietary drug discovery platforms to advance “first in class” and “best in class” drug compounds that target multi-billion dollar market opportunities in the pharmaceutical industry; 3 identifying partners with the development, regulatory and commercial capability to take our drug candidates to market; and 3 securing out-licensing deals that have the potential to deliver multiple future revenue streams, delivering value and mitigating risk. The financial year to 30 June 2013 saw Bionomics Limited achieve important milestones across its pipeline of drug candidates and discovery programs: 3 Completion of enrolment in the multinational phase ii clinical trial of BnC105 in patients with metastatic renal cancer and the phase i ovarian cancer trial. The phase ii trial is evaluating the effect of BnC105 in combination with everolimus (Afinitor) in patients with progressive metastatic renal cell carcinoma that have previously progressed on treatment with tyrosine kinase inhibitors. Afinitor is an mTOR inhibitor used as a treatment after patients have failed therapy with tyrosine kinase inhibitors such as Sutent. Afinitor, approved by the fDA for the treatment of renal cancer in 2009 and marketed by global pharmaceutical company novartis, had sales of uS$700 million in 2012. An update on the status of the phase i component of the trial was provided at the highly regarded oncology conference, ASCO, in June 2013. in summary, phase i data are indicative of clinical benefit and sustained therapy, with patients staying on therapy for up to 18 months. Bionomics also advised in June that enrolment into the phase i ovarian cancer clinical trial had also been completed. it is anticipated that results of these trials will provide the foundation for a significant licensing deal, in line with the Company’s business model. 3 identification of BnC375 as the drug candidate to emerge from the “Alpha 7” program targeting improvement 27 DIRECTORS’ REPORT of memory through modulation of the α7 nicotinic acetylcholine receptor. following announcement of the selection of BnC375 as Bionomics’ drug candidate for the treatment of memory loss in December 2013, data on BnC375 was presented at the 33rd Annual Meeting of the Australian neuroscience Society in february 2013 for the first time. BnC375, which is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor, enhances both episodic memory and working memory and it has equivalent performance in animal models to that of Donepezil, a pfizer product, marketed as Aricept. BnC375 has demonstrated a wide therapeutic window in the preclinical studies conducted to date. This latest drug candidate to come from the Company’s technology platform conforms to Bionomics’ focus on developing well differentiated drug candidates to treat serious conditions such as Alzheimer’s disease, Schizophrenia and parkinson’s disease amongst others. With recent setbacks experienced by global pharmaceutical companies in the development of new drugs to treat Alzheimers disease, Bionomics believes that BnC375 has strong partnership potential. 3 progress in moving the cancer stem cell targeting antibody BnC101 towards clinical trials. The acquisition of uS-based Eclipse Therapeutics (now Bionomics inc) in September 2012 has expanded Bionomics’ presence in oncology and positioned the Company as a leader in the cancer stem cell therapeutic area. Cancer Stem Cells (CSCs) are a distinct class of cancer cells that form the root of a tumour. They are the seeds that give rise to initial tumour formation and if left unchecked they can lead to tumour recurrence and spread. CSCs are more resistant to traditional chemotherapy and radiation therapy and the targeting of cancer stem cells has become a new pathway to attack cancer. With BnC101 in inD-enabling studies, Bionomics is on track to file an investigational new Drug (inD) application in calendar year 2014, paving the way for clinical trials. BnC101, a humanised monoclonal antibody, has demonstrated functional activity against CSCs from primary colorectal cancer (CRC) patient samples. in preclinical studies, BnC101 significantly reduces CSC frequency in vivo and prevents tumour regrowth in long term studies. BnC101 also increases survival and inhibits weight loss in a cachectic CRC tumour model. To date BnC101 has shown no evidence of toxicity in preliminary safety analyses. BnC101 has been highlighted at several international conferences including Molecular Medicine TriCon “Targeting Cancer Stem Cells” in february 2013. 3 Achievement of proof-of-concept milestone by a compound from Bionomics’ collaboration with the Co-operative Research Centre for Cancer Therapeutics. A novel compound, CTx-0357927, suppressed cancer progression as indicated by tumour growth inhibition and number of identified metastases in an animal model of melanoma. CTx-0357927 is an inhibitor of vascular growth factor receptor 3 (vEGfR3), a receptor closely linked to the development of lymphatic vessels which act as a conduit for tumour cells spreading to different sites of the body. uS figures suggest that the overall 5-year survival rate for patients whose melanoma is detected early, before the tumour has spread to the regional lymph nodes or other organs is about 98 per cent. The survival rate falls to 62 per cent when the disease reaches the lymph nodes and 15 per cent when the disease metastasises to distant organs. Melanoma is the fourth most common cancer reported in Australia. in 2008, there were 11,057 new cases of melanoma of the skin in Australia accounting for 9.8 per cent of all new cancers. 3 new data has been generated to support the licensing of Bionomics kv1.3 program for additional indications, particularly for psoriasis. 3 Our European subsidiary, neurofit continued to expand its service offering to customers, securing an additional, new, global pharmaceutical company for its contract research business as well as servicing Bionomics’ internal drug discovery programs. 3 in addition to these internal achievements our partner, ironwood pharmaceuticals, initiated a phase i clinical trial of BnC210 (iW-2143) in the uS. On 31 July 2013 Bionomics announced an agreement with Merck, known as MSD outside the united States and Canada, to discover and develop novel small molecule candidates for the treatment of chronic pain, including neuropathic pain. Merck is a global pharmaceutical company and this research collaboration is validation of Bionomics drug discovery platforms ionX® and MultiCore®. it is also a further example of the Company’s partnership strategy. under the terms of the agreement, Merck will have the option to exclusively license a compound from Bionomics for development and commercialisation. in return, Bionomics may receive option exercise fees and development and regulatory milestone payments of up to uS$172 million. Bionomics may also be eligible for undisclosed royalties on net sales of products from the collaboration. Bionomics retains the right to develop and commercialise certain compounds for which Merck does not exercise its option. The initial period of the research program will be two years. The development of new drugs to treat serious illnesses is an inherently risky process. not all drug candidates will reach market and it is through its “multiple shots on goal” strategy of having a number of drug candidates in the pipeline, licensed to partners with experience in taking new drugs through the complex regulatory process to market that Bionomics is balancing the risk whilst maximising value. 28 OuTLOOk it is anticipated that a number of important R&D milestones will be achieved in fY14 including release of the phase ii results of the clinical trial of BnC105 in metastatic renal cancer, a key ingredient in our partnership strategy for this drug candidate and the progression of the cancer stem targeting antibody BnC101 towards clinical trial in cancer patients. Bionomics will also focus on the continued execution of its partnership strategy across its pipeline of drug candidates with BnC375, for the treatment of cognitive impairment in Alzheimers disease and parkinson’s disease and BnC164 from the kv1.3 autoimmune diseases program, the subject of ongoing discussions. We will place considerable emphasis on alliance management, working with our current partners ironwood, Merck and the Cooperative Research Centre for Cancer Therapeutics in addition to prospective new partners, to deliver value for our shareholders. DiviDEnDS The directors do not propose to make any recommendation for dividends for the current financial year. There were no dividends declared in respect of the previous financial year. SiGnifiCAnT ChAnGES in ThE STATE Of AffAiRS There were no significant changes in the state of affairs of the Group during the financial year. SuBSEquEnT EvEnTS no matters or circumstances have arisen since the end of the financial year which significantly affect or may significantly affect the results of the operations of the Group, except as noted below. On 31 July 2013 Bionomics announced an agreement with Merck, known as MSD outside the united States and Canada, to discover and develop novel small molecule candidates for the treatment of chronic pain. Merck will have the option to exclusively license a compound from Bionomics for development and commercialisation. in return, Bionomics may receive option exercise fees and development and regulatory milestone payments of up to uS$172 million. Bionomics may also be eligible for undisclosed royalties on net sales of products from the collaboration. LikELY DEvELOpMEnTS AnD EXpECTED RESuLTS Of OpERATiOnS The Group will continue to undertake drug discovery and will seek to commercialise the outcomes of its research and development in the form of diagnostic products and drugs for the treatment of disease. EnviROnMEnTAL REGuLATiOn The Group is subject to environmental regulations and other licenses in respect of its research facilities in Thebarton (South Australia), Bionomics inc in San Diego (uSA) and for neurofit in Strasbourg (france). The Group is subject to regular inspections and audits by responsible State and federal authorities. The Group was in compliance with all the necessary environmental regulations throughout 2012 - 2013 and no related issues have arisen since the end of the financial year to the date of this report. INFORMATION ON DIRECTORS Mr Graeme Kaufman Chairman - non-Executive Director Director since 18 September 2012 Experience and Expertise Mr kaufman has wide ranging experience across the biotechnology sector, spanning scientific, commercial and financial areas. his experience with CSL Limited, Australia’s largest biopharmaceutical company included responsibility for all of their manufacturing facilities, and the operation of an independent business division operating in the high technology medical device market. As CSL’s General Manager finance, Mr kaufman had global responsibility for finance, strategy development, human resources and information technology. Mr kaufman has also served as an executive director of ASX-listed Circadian Technologies and a non-executive director of Amrad Corporation. he was previously Executive vice president Corporate finance with Mesoblast Limited and is currently a non-executive director of iDT Australia Limited and Cellmid Limited. Current Directorships (in addition to Bionomics Limited) Listed: non-Executive Director, Cellmid Limited (ASX:CDY) (since August 2012); non-Executive Director, iDT Limited (ASX:iDT) (since June 2013) Former Listed Directorships in Last Three Years none Special Responsibilities Member of Audit and Risk Management Committee Interests in Shares and Options at Date of Report 178,750 ordinary shares in Bionomics Limited 500,000 unlisted options over ordinary shares in Bionomics Dr Deborah Rathjen BSc (Hons), MAICD, PhD Chief Executive Officer and Managing Director Director since 18 May 2000 Experience and Expertise Dr Rathjen joined Bionomics in 2000 from peptech Limited, where she was general manager of business development and licensing. Dr Rathjen was a co-inventor of peptech’s Tnf technology and leader of the company’s successful defence of its key Tnf patents against a legal challenge by BASf. Dr Rathjen has significant experience in research, business development and licensing and specific expertise in inflammation and cancer. Dr Rathjen is Chairperson of the AusBiotech Board. 29 DIRECTORS’ REPORT Current Directorship (in addition to Bionomics Limited) Listed: nil Other: Director and Chairperson of AusBiotech Limited (since 2008) Former Listed Directorships in Last Three Years none Special Responsibilities Chief Executive Officer and Managing Director Interests in Shares and Options at Date of Report 1,965,401 ordinary shares in Bionomics Limited 2,755,000 unlisted options over ordinary shares in Bionomics Limited Mr Trevor Tappenden CA, FAICD non-Executive Director Director since 15 September 2006 Experience and Expertise Mr Tappenden commenced a career as a non-Executive Director in 2003 after a career with Ernst & Young spanning 30 years. During his time at Ernst & Young Mr Tappenden held a variety of positions including Managing partner of the Melbourne Office, member of the Board of partners, head of the victorian Government Services Group and national Director of the Entrepreneurial Services Division. he holds directorship in various private, government and not-for- profit organisations and is the Chairman of the Audit and Risk Management Committees of many of those organisations. Current Directorships (in addition to Bionomics Limited) Listed companies: nil Other: Director, Buckfast pty Ltd; Director, Advanced Manufacturing CRC; Director, intellicomms pty Ltd; Director, RMiT university vietnam; Director (Chairman), RMiT university foundation Former Listed Directorships in Last Three Years Director, Metal Storm Limited Special Responsibilities Chairman of Audit and Risk Management Committee Interests in Shares and Options at Date of Report 247,500 ordinary shares in Bionomics Limited 400,000 unlisted options over ordinary shares in Bionomics Limited Dr Errol De Souza non-Executive Director Director since 28 february 2008 Experience and Expertise Dr De Souza is a leader in the development of therapeutics for treatment of central nervous system (CnS) disorders. he is currently president and CEO of leading uS company Biodel inc (nasdaq:BiOD) and is the former president and CEO of uS biotech companies Archemix Corporation and Synaptic pharmaceutical Corporation. Dr De Souza formerly held senior management positions at Aventis and its predecessor hoechst Marion Roussel pharmaceuticals, inc. Most recently, he was Senior vice president and Site head of uS Drug innovation and Approval (R&D), at Aventis, where he was responsible for the discovery and development of drug candidates through phase iia clinical trials for CnS and inflammatory disorders. prior to Aventis, he was a co- founder and Chief Scientific Officer of neurocrine Biosciences (nasdaq:nBiX). Dr De Souza has served on multiple editorial boards, national institutes of health (nih) Committees and is currently a Director of several public and private companies. Current Directorships (in addition to Bionomics Limited) Listed companies: Director of Biodel inc (nasdaq:BiOD), Director of Targacept, inc (nasdaq:TRGT) Former Listed Directorships in Last Three Years Director of palatin Technologies, inc (Amex:pTn); Massachusetts Biotechnology Council Special Responsibilities none Interests in Shares and Options at Date of Report 116,698 ordinary shares in Bionomics Limited 500,000 unlisted options over ordinary shares in Bionomics Limited Dr Jonathan Lim non-Executive Director Director since 14 September 2012 Experience and Expertise Jonathan Lim, MD is Managing partner of City hill ventures, LLC, which he established in 2010 prior to co-founding Eclipse in early 2011. Dr Lim was formerly president, CEO and Board Director of halozyme Therapeutics, inc where he grew the company from five employees and a market value of $5 million in May 2003 to 140 employees and peak market capitalisation of nearly $1 billion during his tenure. under Dr Lim’s eight years of leadership, the company went public and raised $300 million from financing and corporate partnerships with Roche and Baxter, achieved two uS fDA approvals and built a late stage pipeline of two phase iii, two phase ii and two phase i product candidates. Dr Lim’s prior experience includes management consulting at Mckinsey, nih postdoctoral fellowship at harvard and general surgery residency at new York hospital-Cornell. he has BS and MS degrees from Stanford, MD from McGill and Mph from harvard. Current Directorships (in addition to Bionomics Limited) Listed companies: nil Other: Managing partner, City hill ventures, LLC Former Listed Directorships in Last Three Years president, halozyme Therapeutics, inc (nasdaq:hALO) Special Responsibilities none Interests in Shares and Options at Date of Report 4,073,463 ordinary shares in Bionomics Limited 500,000 unlisted options over ordinary shares in Bionomics Limited 30 COMpAnY SECRETARY The Company Secretary is Ms Melanie Young. Ms Young was appointed to the position of Company Secretary and Chief financial Officer in May 2011. Ms Young has over 14 years’ experience, with six years in the medical device field, including two years as CfO of an ASX-listed company covering all facets of the company’s global finance function. Ms Young has considerable commercial experience in listed company reporting requirements, international finances and working capital management. Ms Young has also gained experience in negotiating distributor agreements, due diligence, cost reduction strategies and improving operating efficiencies. previously Ms Young worked for Deloitte Touche Tohmatsu in the Growth Solutions Division. Ms Young holds a Bachelor of Commerce from Deakin university and is a Chartered Accountant. MEETinGS Of DiRECTORS The numbers of meetings of the Company’s Board and of each Board committee held during the year ended 30 June 2013, and the numbers of meetings attended by each director were: MEETINGS OF AUDIT AND RISK MANAGEMENT (ARM) COMMITTEE MEETINGS OF DIRECTORS A 9 12 12 12 9 6 B 9 12 12 12 9 6 A 2*** ** 4 ** ** 2 B 2 ** 4 ** ** 2 Mr Graeme kaufman Dr Deborah Rathjen* Mr Trevor Tappenden Dr Errol De Souza Dr Jonathan Lim Mr Christopher fullerton A number of meetings held during the time the director held office or was a member of the committee during the year and was entitled to attend. B number of meetings attended. * ** not a member of the relevant committee, may attend by not a non-executive director. invitation. *** Mr kaufman attended an additional meeting prior to being appointment to the ARM Committee. REMUNERATION REPORT The remuneration report is set out under the following main headings: 1. pRinCipLES uSED TO DETERMinE ThE nATuRE AnD AMOunT Of REMunERATiOn 2. DETAiLS Of REMunERATiOn 3. SERviCE AGREEMEnTS 4. ShARE-BASED COMpEnSATiOn 5. ADDiTiOnAL infORMATiOn 1. pRinCipLES uSED TO DETERMinE ThE nATuRE AnD AMOunT Of REMunERATiOn The objective of the Group’s key management personnel remuneration framework is to ensure that reward for performance is competitive and appropriate for the results delivered. The framework aligns key management personnel rewards with achievement of strategic objectives and the creation of value for shareholders. key management personnel remuneration and other terms of employment are determined by the Board having regard to performance, relevant comparative information and the Group’s financial performance. Remuneration packages are set at levels that are intended to attract and retain first class key management personnel capable of managing the Group’s operations and achieving the Group’s strategic objectives. The framework provides a mix of base cash remuneration and performance-based remuneration through the Bionomics Limited Employee Share Option plan (the Bionomics ESOp) in order to align the interests of key management personnel with those of shareholders. Non-Executive Directors fees and payments to non-executive directors reflect the demands that are made on and the responsibilities of the directors. non-executive directors may receive share options at the time of their initial appointment to the Board or at other such times as approved by shareholders. Directors’ Fees non-executive directors’ fees are determined within an aggregate directors’ fee pool limit that is periodically recommended for approval by shareholders under the Constitution. The current aggregate non-executive directors’ fee pool limit is $500,000 per annum (as approved by shareholders at the AGM held on 14 november 2012). The Chairman and non-executive directors’ fees are $120,000 per annum and $65,000 per annum respectively, inclusive of superannuation. The Chairman of the Audit and Risk Management Committee, 31 DIRECTORS’ REPORT Mr Trevor Tappenden, received an additional $15,000 per annum inclusive of superannuation for services relating to his Audit and Risk Management Committee duties. Dr Errol De Souza received an additional $15,000 per annum inclusive of superannuation for being a member of the Scientific Advisory Board. Any value that may be attributed to options issued to non-executive directors is not included in the shareholder approved aggregate limit of directors’ fees applying from time to time. Retirement Allowance for Directors The Group does not provide retirement allowances for its non-executive directors. Key Management Personnel Remuneration The key management personnel pay and reward framework has three components: 3 a cash remuneration package, including superannuation and other entitlements; 3 longer-term incentives through participation in the Bionomics ESOp; and 3 in exceptional circumstances, a cash bonus may be paid. The combination of these comprises the key management personnel’s total remuneration. Base Remuneration The cash remuneration package of key management personnel is structured as a total employment cost package that may be delivered as a mix of cash and prescribed salary sacrifice benefits at the key management personnel’s discretion, inclusive of superannuation or equivalent retirement benefits. Remuneration levels are reviewed annually and an assessment made against market comparable roles balanced with individual key management personnel’s performance and the Group’s financial position. The key management personnel’s remuneration may also be reviewed on promotion. The Board reviews and approves the salary of the Chief Executive Officer and Managing Director and other key management personnel directly reporting to the Chief Executive Officer and Managing Director. There is no link between the company’s performance and the setting of remuneration except as discussed on page 36 in relation to options and cash bonuses for certain executives. There are no guaranteed base pay increases for key management personnel. Retirement Benefits Retirement benefits through superannuation (or local equivalent) are paid for all Group employees in line with relevant legislative requirements into funds nominated by the individual employee. The Group does not have any on-going responsibility for the individual employee superannuation and does not have in place a defined benefits plan for employees in Australia. The Bionomics ESOP information on the Bionomics ESOp is set out in section 4 of this Remuneration Report. 2. DETAiLS Of REMunERATiOn Details of the remuneration of each director of Bionomics and each of the other key management personnel (as defined in the Corporations Act 2001) are set out in the following tables. Non-Executive Chairman Mr Graeme kaufman (appointed 18 September 2012) Executive Director Dr Deborah Rathjen, Chief Executive Officer and Managing Director Non-Executive Directors Mr Trevor Tappenden Dr Errol De Souza Dr Jonathan Lim (appointed 14 September 2012) Mr Christopher fullerton (retired 31 December 2012) 32 The following persons were the key company and group executives and those persons having authority and responsibility for planning, directing and controlling the activities of the consolidated entity, directly or indirectly, including any director (whether executive or otherwise) of the consolidated entity (key Management personnel) during the financial year and the prior year unless otherwise stated: Name Dr Deborah Rathjen Dr José iglesias Ms Melanie Young Position Chief Executive Officer and Managing Director Chief Medical Officer (appointed 1 november 2012) Chief financial Officer and Company Secretary Details of options granted by Bionomics to and exercised by directors, other key management personnel and the five highest remunerated officers during the year ended 30 June 2013 are set out further in this report. DIRECTORS AND OTHER KEY MANAGEMENT PERSONNEL – 2013 SHORT-TERM BENEFITS CASH SALARY AND FEES $ NON- MONETARY BENEFITS $ 78,249 48,739 73,395 80,000 51,458 419,820 270,330 156,047 1,178,038 - - - - - 53,710 - 13,678 67,388 NAME Mr Graeme kaufman3 Mr Christopher fullerton5 Mr Trevor Tappenden Dr Errol De Souza Dr Jonathan Lim2 Dr Deborah Rathjen1 Dr José iglesias4 Ms Melanie Young TOTALS POST EMPLOYMENT SHARE-BASED PAYMENTS SUPERANNUATION $ SHARES $ OPTIONS $ OPTIONS % OF TOTAL % 16.25 23.79 - 1.26 24.34 TOTAL $ 101,842 69,711 80,000 81,024 68,009 16,551 16,586 - 1,024 16,551 (8,255) (1.71) 481,745 2,398 51,170 96,025 0.88 21.67 272,728 236,170 6.90 1,391,229 7,042 4,386 6,605 - - 16,470 - 15,275 49,778 - - - - - - - - - 12013 includes the reversal of the estimated fair value of options at 30 June 2013 ($48,900) and the actual fair value at vesting date 15 August 2012 of $33,300. 2Appointed 14 September 2012. 3Appointed 18 September 2012. 4Appointed 1 november 2012. 5Retired 31 December 2012. DIRECTORS AND OTHER KEY MANAGEMENT PERSONNEL – 2012 SHORT-TERM BENEFITS CASH SALARY AND FEES $ NON- MONETARY BENEFITS $ 100,917 68,807 75,000 398,600 147,443 790,767 - - - 60,625 8,520 69,145 POST EMPLOYMENT SHARE-BASED PAYMENTS SUPERANNUATION $ SHARES $ OPTIONS $ OPTIONS % OF TOTAL % TOTAL $ 9,083 6,193 - 15,775 14,037 45,088 - - - - 28,659 20.67 138,659 1,022 4,243 1.34 5.35 76,022 79,243 140,963 22.88 615,963 1,000 31,341 15.49 202,341 1,000 206,228 18.54 1,112,228 NAME Mr Christopher fullerton Mr Trevor Tappenden Dr Errol De Souza Dr Deborah Rathjen6 Ms Melanie Young TOTALS 6Dr Rathjen’s options expense for services performed during the year includes an estimate at 30 June 2012 of the fair value of options granted in August 2012 relating to the commercialisation incentive options approved at the 2011 AGM. 33 DIRECTORS’ REPORT Options are granted to directors and other key management personnel under the Bionomics ESOp, details of which are set out in section 4 of this Remuneration Report. no director or senior management person appointed during the period received a payment as part of their consideration for agreeing to hold the position. 3. SERviCE AGREEMEnTS Remuneration and other terms of employment for the Chief Executive Officer and Managing Director and the other key management personnel are formalised in service agreements. Major provisions of the agreements relating to remuneration are set out below: Dr Deborah Rathjen Chief Executive Officer and Managing Director 3 Term of agreement – 5 years commencing 15 October 2010. 3 Total remuneration package for the year ended 30 June 2013 of $490,000 per annum (excluding options), to be reviewed annually by the Board. 3 payment of termination benefit on early termination by the employer without cause equal to six months’ salary. in the event of redundancy, purchase or merger of Bionomics by a third party resulting in a material diminution in duties, an additional six months’ salary will be paid. Dr José Iglesias Chief Medical Officer 3 Term of agreement – open, commencing 1 november 2012. 3 Total remuneration package for the year ended 30 June 2013 of $405,495 per annum, pro-rated (excluding options) to be reviewed annually by the Chief Executive Officer & Managing Director and approved by the Board. 3 payment of termination benefit on early termination by the employer without cause equal to three months’ salary. in the event of redundancy, purchase or merger of Bionomics by a third party resulting in a material diminution in duties, six months’ salary will be paid. Ms Melanie Young Chief financial Officer and Company Secretary 3 Term of agreement – open, commencing 9 May 2011. 3 Total remuneration package for the year ended 30 June 2013 of $185,000 per annum (excluding options and shares) to be reviewed annually by the Chief Executive Officer and Managing Director and approved by the Board. 3 payment of termination benefit on early termination by the employer without cause equal to three months’ salary. in the event of redundancy, purchase or merger of Bionomics by a third party resulting in a material diminution in duties, six months’ salary will be paid. 4. ShARE-BASED COMpEnSATiOn Share-based compensation benefits are provided to employees via the Bionomics ESOp and an Employee Share plan. The market value of shares issued to employees for no cash consideration under the Employee Share plan is recognised as an employee benefits expense with a corresponding increase in equity when the employees become unconditionally entitled to the shares. The Bionomics ESOp was approved by the Board and Shareholders in 2011. Staff eligible to participate in the plan are those who have been a full-time or part-time employee of the Group for a period of not less than six months or a director of the Company. Options are granted under the plan for no consideration and vest equally over five years, unless they are bonus options which vest immediately. The amounts disclosed as remuneration relating to options are the assessed fair values at grant date of those options allocated equally over the period from grant date to vesting date. fair values at grant date are independently determined using a Black-Scholes option pricing model that takes into account the exercise price, the term of the option, the vesting and performance criteria, the impact of dilution, the non-tradeable nature of the option, the share price at grant date, expected price volatility of the underlying share, the expected dividend yield and the risk- free interest rate for the term of the option. The terms and conditions of each grant of options affecting remuneration of directors, other key management personnel and any of the top five salaried officers in this or future reporting periods appear on the following page: 34 FAIR VALUE PER OPTION AT GRANT DATE VESTING DATE $0.1211 16 november 2008 $0.1264 $0.1307 $0.1343 $0.0875 $0.0963 $0.1042 $0.1114 $0.1178 $0.0737 $0.0828 $0.0915 $0.0993 16 november 2009 16 november 2010 16 november 2011 5 november 2008 5 november 2009 5 november 2010 5 november 2011 5 november 2012 5 november 2008 7 August 2009 7 August 2010 7 August 2011 $0.1527 25 november 2011 $0.0333 $0.2344 $0.2487 15 August 2012 12 December 2012 12 December 2013 $0.2611 12 December 2014 $0.2720 $0.2818 12 December 2015 12 December 2016 $0.0942 $0.1130 $0.1226 $0.1310 $0.1383 $0.1449 $0.1509 $0.1425 $0.1525 $0.1614 $0.1696 $0.1768 1 August 2012 11 December 2012 11 December 2013 11 December 2014 11 December 2015 11 December 2016 11 December 2017 5 June 2014 5 June 2015 5 June 2016 5 June 2017 5 June 2018 GRANT DATE EXPIRY DATE EXERCISE PRICE Granted in prior periods November 2006 November 2008 November 2011 December 2011 Granted in current period August 2012 December 2012 June 2013 16 november 2013 16 november 2014 16 november 2015 16 november 2016 5 november 2013 5 november 2014 5 november 2015 5 november 2016 5 november 2017 5 november 2013 7 August 2014 7 August 2015 7 August 2016 25 november 2016 25 november 2016 12 December 2017 12 December 2018 12 December 2019 12 December 2020 12 December 2021 1 August 2017 11 December 2017 11 December 2018 11 December 2019 11 December 2020 11 December 2021 11 December 2022 5 June 2019 5 June 2020 5 June 2021 5 June 2022 5 June 2023 Options granted under the plan carry no dividend or voting rights. $0.30 $0.30 $0.30 $0.30 $0.30 $0.30 $0.30 $0.30 $0.30 $0.3716 $0.3716 $0.3716 $0.3716 $0.614 $0.921 $0.518 $0.518 $0.518 $0.518 $0.518 $0.287 $0.287 $0.32 $0.32 $0.32 $0.32 $0.32 $0.3873 $0.3873 $0.3873 $0.3873 $0.3873 35 DIRECTORS’ REPORT OpTiOnS pROviDED AS REMunERATiOn unDER ThE ESOp in ThE CuRREnT YEAR Details of options over ordinary shares in the Company provided as remuneration to each director and each of the other key management personnel are set out below. When exercisable, each option is convertible into one ordinary share of Bionomics. During the year, and since the end of the year, options were issued to the following directors and other key management personnel: NAME NUMBER GRANTED DATE GRANTED TOTAL FAIR VALUE $ NUMBER VESTED % OF GRANT VESTED % OF GRANT FORFEITED Dr Deborah Rathjen1 65,000 11 Dec 2012 Dr Deborah Rathjen2 1,000,000 25 nov 2011 Ms Melanie Young1 75,000 1 Aug 2012 Mr Graeme kaufman3 500,000 11 Dec 2012 Dr Jonathan Lim3 Dr José iglesias3 500,000 11 Dec 2012 500,000 5 Jun 2013 7,345 33,300 7,065 68,769 68,769 80,280 65,000 1,000,000 75,000 - - - 100% 100% 100% - - - - - - - - - 1The options vested immediately. 2The options were issued in november 2011 and vested after the end of the financial year after successful achievement of agreed major partnering deal milestone. The fair value was estimated at 30 June 2013 and the final fair value calculated at the vesting date of 15 August 2012. 3The options vest after completion of a specified service period. OpTiOnS EXERCiSED in ThE CuRREnT YEAR During the year, the following directors and other key management personnel exercised options that were granted to them as part of their compensation. Each option converts into one ordinary share of Bionomics. NAME NUMBER OF OPTIONS EXERCISED NUMBER OF ORDINARY SHARES ISSUED AMOUNT PAID $ AMOUNT UNPAID $ Dr Deborah Rathjen 430,000 430,000 70,300 - The following table summarises the value of options granted, exercised or lapsed during the financial year to directors and other key management personnel: NAME Dr Deborah Rathjen Ms Melanie Young Mr Trevor Tappenden Mr Graeme kaufman Dr Jonathan Lim Dr José iglesias VALUE OF OPTIONS GRANT AT THE GRANT DATE1 $ VALUE OF OPTIONS EXERCISED AT THE EXERCISE DATE $ VALUE OF OPTIONS LAPSED AT THE DATE OF LAPSE2 $ 7,345 7,065 - 68,769 68,769 80,280 81,100 - - - - - - - (11,470) - - - 1The value of options granted during the period is recognised in compensation over the vesting period of the grant, in accordance with Australian Accounting Standards. 2The value of options lapsing during the period due to the failure to satisfy a vesting condition is determined assuming the vesting condition has been satisfied. 36 5. ADDiTiOnAL infORMATiOn Principles Used to Determine the Nature and Amount of Remuneration; Relationship between Remuneration and Company Performance Base salary amounts are determined based on market information for similar roles in comparable industries. Other than market information, there is no link between the base salary determination and Company performance. The calculation of the key management personnel annual bonus is set against the achievement of specified milestones and targets approved by the Board. Milestones and targets generally relate to achieving developmental milestones for each pipeline project, such as achieving inD registrations by particular dates or project related milestones by particular dates. These milestones are established to support the Company achieving its overall objectives. The tables below set out summary information about the consolidated entity’s earnings and movements in shareholder wealth for the five years to 30 June 2013. 30 JUNE 2013 $ 30 JUNE 2012 $ 30 JUNE 2011 $ 30 JUNE 2010 $ 30 JUNE 2009 $ Revenue net loss before tax net loss after tax 3,724,169 6,834,709 4,071,798 (9,963,175) (3,328,896) (10,106,903) (10,001,350) (3,136,238) (9,356,497) 3,848,469 (8,214,082) (8,214,082) 4,296,496 (6,899,183) (6,862,299) 30 JUNE 2013 CENTS 30 JUNE 2012 CENTS 30 JUNE 2011 CENTS 30 JUNE 2010 CENTS 30 JUNE 2009 CENTS Share price at start of year Share price at end of year Dividends paid Basic earnings per share Diluted earnings per share 30.0 34.0 - (2.7) (2.7) 55.5 30.0 - (0.9) (0.9) 27.0 55.5 - (2.9) (2.9) 21.0 27.0 - (2.7) (2.7) 34.0 21.0 - (2.8) (2.7) Other Transactions with Directors and Other Key Management Personnel There were no other transactions with Directors or other key management personnel during the financial year. OTHER INFORMATION ShARES unDER OpTiOn information relating to shares under option is set out in section 4 of the Remuneration Report. The total number of shares under option at 30 June 2013 was 10,262,274. ShARES iSSuED On ThE EXERCiSE Of OpTiOnS 958,026 ordinary shares of Bionomics were issued during the year ended 30 June 2013 on the exercise of options granted under the Bionomics ESOp. inSuRAnCE Of OffiCERS During the financial year, the Company paid a premium to insure the Directors and Officers (D&O) of the Company. under the terms of this policy the premium paid by the Company is not permitted to be disclosed. The liabilities insured are legal costs that may be incurred in defending civil or criminal proceedings that may be brought against the D&O in their capacity as D&O of the Company, and any other payments arising from liabilities incurred by the D&O in connection with such proceedings, other than where such liabilities arise out of conduct involving a wilful breach of duty by the D&O or the improper use by the D&O of their position or of information to gain advantage for themselves or someone else or to cause detriment to the Company. it is not possible to apportion the premium between amounts relating to the insurance against legal costs and those relating to other liabilities. 37 DIRECTORS’ REPORT The Company has not otherwise, during or since the end of the financial year, except to the extent permitted by law, indemnified or agreed to indemnify an officer or auditor of the Company or of any related body corporate against a liability incurred as such an officer or auditor. nOn-AuDiT SERviCES The Company may decide to employ the external auditor on assignments additional to their statutory audit duties where the external auditor’s expertise and experience with the Group are important. Details of the amounts paid to the external auditor for audit and non-audit services provided during the year are set out in note 26 to the financial statements. The Board has considered the position and, in accordance with the advice received from the Audit and Risk Management Committee, is satisfied that the provision of the non-audit services is compatible with the general standard of independence for external auditors imposed by the Corporations Act 2001. The directors are satisfied that the provision of non-audit services by the external auditor, as set out in note 26 to the financial statements, did not compromise the external auditor independence requirements of the Corporations Act 2001 for the following reasons: 3 all non-audit services have been reviewed by the Audit and Risk Management Committee to ensure they do not impact the integrity, impartiality and objectivity of the external auditor; and 3 none of the services undermine the general principles relating to auditor independence as set out in Code of Conduct ApES 110, Code of Ethics for professional Accountants, issued by the Accounting professional & Ethical Standards Board, including reviewing or auditing the external auditor’s own work, acting in a management or a decision-making capacity for the Company, acting as advocate for the Company or jointly sharing economic risk and rewards. EXTERnAL AuDiTOR Deloitte Touche Tohmatsu continues in office in accordance with section 327 of the Corporations Act 2001. A copy of the auditors’ independence declaration as required under section 307C of the Corporations Act 2001 is set out on page 38. This directors’ report is signed in accordance with a resolution of directors made pursuant to Section 298(2) of the Corporations Act 2001. Graeme Kaufman Chairman Adelaide 15 August 2013 Deborah Rathjen Chief Executive Officer and Managing Director Adelaide 15 August 2013 38 AuDITORS’ INDEPENDENCE DEClARATION 39 ANNuAl FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 TABlE OF CONTENTS PG 39 ANNuAl FINANCIAl STATEMENTS PG 40 CONSOlIDATED STATEMENT OF PROFIT OR lOSS AND OTHER COMPREHENSIVE INCOME PG 41 CONSOlIDATED STATEMENT OF FINANCIAl POSITION PG 42 CONSOlIDATED STATEMENT OF CHANGES IN EQuITY PG 43 CONSOlIDATED STATEMENT OF CASH FlOWS PG 44 NOTES TO THE FINANCIAl STATEMENTS PG 81 DIRECTORS’ DEClARATION PG 82 INDEPENDENT AuDIT REPORT PG 84 SHAREHOlDER INFORMATION This financial statement covers both Bionomics Limited (“Bionomics”) as an individual entity (note 31) and the Group consisting of Bionomics and its subsidiaries. A description of the nature of the Group’s operations and its principal activities is included throughout the Annual Report and the Directors’ Report. The financial statement is presented in Australian dollars. Bionomics is a company limited by shares, incorporated and domiciled in Australia. it is listed on the ASX (ASX:BnO) and its registered office is 31 Dalgleish Street, Thebarton, SA 5031. Through the internet, we have ensured that our corporate reporting is timely, complete and available globally at minimum cost to the company. All press releases, financial statements and other information are available on our website www.bionomics.com.au. TABlE OF CONTENTS PG 39 ANNuAl FINANCIAl STATEMENTS PG 40 CONSOlIDATED STATEMENT OF PROFIT OR lOSS AND OTHER COMPREHENSIVE INCOME PG 41 CONSOlIDATED STATEMENT OF FINANCIAl POSITION PG 42 CONSOlIDATED STATEMENT OF CHANGES IN EQuITY PG 43 CONSOlIDATED STATEMENT OF CASH FlOWS PG 44 NOTES TO THE FINANCIAl STATEMENTS PG 81 DIRECTORS’ DEClARATION PG 82 INDEPENDENT AuDIT REPORT PG 84 SHAREHOlDER INFORMATION 40 CONSOlIDATED STATEMENT OF PROFIT OR lOSS AND OTHER COMPREHENSIVE INCOME FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 CONTINUING OPERATIONS Revenue Other income EXPENSES Administrative financing costs Occupancy Compliance Loss on disposal of assets Research and development Loss before tax income tax (expense)/benefit Loss after tax NOTE 30 JUNE 2013 $ 30 JUNE 2012 $ 4 4 5 6 3,724,169 8,101,787 11,825,956 3,352,156 78,198 1,586,144 601,944 184 16,170,505 (9,963,175) (38,175) (10,001,350) 6,834,709 3,102,837 9,937,546 2,313,932 64,450 1,417,022 361,872 5,824 9,103,342 (3,328,896) 192,658 (3,136,238) Other comprehensive income items that may be reclassified subsequently to profit or loss: Exchange differences on translation of foreign operations Total comprehensive income for the year Loss attributable to: Owners of the Company EARNINGS PER SHARE FROM CONTINUING OPERATIONS Basic loss per share Diluted loss per share NOTE 29 29 1,894,514 (8,106,836) (93,612) (3,229,850) (8,106,836) (3,229,850) 2013 CENTS (2.7) (2.7) 2012 CENTS (0.9) (0.9) THE ABOVE CONSOlIDATED STATEMENT OF PROFIT OR lOSS AND OTHER COMPREHENSIVE INCOME SHOulD BE READ IN CONJuNCTION WITH THE ACCOMPANYING NOTES. 41 CONSOlIDATED STATEMENT OF FINANCIAl POSITION AS AT 30 JuNE 2013 NOTE 30 JUNE 2013 $ 30 JUNE 2012 $ CURRENT ASSETS Cash and bank balances Trade and other receivables Other financial assets inventories Current tax asset Other assets TOTAL CURRENT ASSETS NON-CURRENT ASSETS property, plant and equipment intangible assets Deferred tax asset TOTAL NON-CURRENT ASSETS TOTAL ASSETS CURRENT LIABILITIES Trade and other payables Borrowings provisions Other liabilities TOTAL CURRENT LIABILITIES NON-CURRENT LIABILITIES Other payables Borrowings provisions Contingent consideration TOTAL NON-CURRENT LIABILITIES TOTAL LIABILITIES NET ASSETS EQUITY Capital Reserves Accumulated losses Equity attributable to owners of the Company 7 8 9 10 6 11 13 14 6 15 16 17 18 15 16 17 32 19 20 21 22,452,089 17,336,609 705,722 - 98,526 36,648 7,422,513 30,715,498 842,850 22,052,744 - 22,895,594 53,611,092 4,283,609 680,376 1,081,086 37,447 6,082,518 306,410 400,159 66,327 5,348,695 6,121,591 12,204,109 41,406,983 111,312,572 2,918,670 (72,824,259) 41,406,983 411,417 36,232 135,284 360,386 3,458,142 21,738,070 773,247 8,520,206 70,665 9,364,118 31,102,188 2,828,220 732,819 888,808 18,188 4,468,035 272,855 443,942 18,239 - 735,036 5,203,071 25,899,117 87,834,778 887,248 (62,822,909) 25,899,117 THE ABOVE CONSOlIDATED STATEMENT OF FINANCIAl POSITION SHOulD BE READ IN CONJuNCTION WITH THE ACCOMPANYING NOTES. 42 CONSOlIDATED STATEMENT OF CHANGES IN EQuITY FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 ISSUED CAPITAL $ OTHER CAPITAL CONTRIBUTED FOREIGN CURRENCY TRANSLATION RESERVE $ SHARE- BASED PAYMENTS RESERVE $ ACCUMULATED LOSSES $ TOTAL $ BALANCE AT 1 JULY 2011 87,690,990 Loss for the period Exchange differences on translation of foreign operations Total comprehensive income Recognition of share-based payments issue of ordinary shares under Employee Share Option plan issue of ordinary shares under Employee Share plan - - - - 104,788 39,000 BALANCE AT 30 JUNE 2012 87,834,778 BALANCE AT 1 JULY 2012 87,834,778 Loss for the period Exchange differences on translation of foreign operations Total comprehensive income Recognition of share-based payments - - - - Rights issue net of costs 15,602,162 - - - - - - - - - - - - - - - (552,274) 1,247,135 (59,686,671) 28,699,180 - (93,612) (93,612) - - - (3,136,238) (3,136,238) - (93,612) (3,136,238) (3,229,850) - - - 285,999 - - - - - 285,999 104,788 39,000 (645,886) 1,533,134 (62,822,909) 25,899,117 (645,886) 1,533,134 (62,822,909) 25,899,117 - 1,894,514 1,894,514 - - - - - - - 136,908 - - - (10,001,350) (10,001,350) - 1,894,514 (10,001,350) (8,106,836) - - - - 136,908 15,602,162 227,041 7,648,591 issue of ordinary shares under Employee Share Option plan issue of ordinary shares, net of transaction costs & income tax 227,041 6,116,024 1,532,567 BALANCE AT 30 JUNE 2013 109,780,005 1,532,567 1,248,628 1,670,042 (72,824,259) 41,406,983 THE ABOVE CONSOlIDATED STATEMENT OF CHANGES IN EQuITY SHOulD BE READ IN CONJuNCTION WITH THE ACCOMPANYING NOTES. 43 CONSOlIDATED STATEMENT OF CASH FlOWS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 CASH FLOWS FROM OPERATING ACTIVITIES Grants received Receipts from customers payments to suppliers and employees Tax refund financing costs NOTE 2013 $ 4,201,787 2,984,760 (17,452,589) 293,534 (9,972,508) (78,198) Net cash used in operating activities 27 (10,050,706) CASH FLOWS FROM INVESTING ACTIVITIES interest received payments for purchases of property, plant & equipment proceeds from sale of property, plant & equipment net cash acquired on acquisition Acquisition transaction costs Net cash (used in) / generated by investing activities CASH FLOWS FROM FINANCING ACTIVITIES Repayment of borrowings proceeds from borrowings net proceeds from share issues Net cash generated by / (used in) financing activities Net increase in cash and cash equivalents Cash at the beginning of the financial year Effect of exchange rate changes on the balances of cash held in foreign currency 2012 $ 2,837 5,997,281 (10,515,621) 565,811 (3,949,692) (64,450) (4,014,142) 1,123,099 (648,797) 6,388,521 - - 6,862,823 (2,310,658) 652,394 104,788 (1,553,476) 1,295,205 16,052,230 636,871 (172,678) - 256,279 (1,409,134) (688,662) (183,820) 87,594 15,829,202 15,732,976 4,993,608 17,336,609 121,872 (10,826) Cash and cash equivalents at the end of the year 7 22,452,089 17,336,609 THE ABOVE CONSOlIDATED STATEMENT OF CASH FlOWS SHOulD BE READ IN CONJuNCTION WITH THE ACCOMPANYING NOTES. 44 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 TABlE OF CONTENTS PG 45 nOTE 1: SuMMARY Of SiGnifiCAnT ACCOunTinG pOLiCiES PG 53 nOTE 2: CRiTiCAL ACCOunTinG ESTiMATES AnD JuDGEMEnTS PG 53 nOTE 3: SEGMEnT infORMATiOn PG 56 nOTE 4: REvEnuE AnD OThER inCOME PG 56 nOTE 5: EXpEnSES PG 57 nOTE 6: inCOME TAXES PG 59 nOTE 7: CASh AnD CASh EquivALEnTS PG 59 nOTE 8: TRADE AnD OThER RECEivABLES PG 60 nOTE 9: OThER finAnCiAL ASSETS PG 60 nOTE 10: invEnTORiES PG 60 nOTE 11: OThER ASSETS PG 60 nOTE 12: SuBSiDiARiES PG 61 nOTE 13: pROpERTY, pLAnT AnD EquipMEnT PG 62 nOTE 14: inTAnGiBLE ASSETS PG 63 nOTE 15: TRADE AnD OThER pAYABLES PG 64 nOTE 16: BORROWinGS PG 64 nOTE 17: pROviSiOnS PG 64 nOTE 18: OThER LiABiLiTiES PG 64 nOTE 19: iSSuED CApiTAL PG 69 nOTE 20: RESERvES PG 69 nOTE 21: ACCuMuLATED LOSSES PG 69 nOTE 22: finAnCiAL inSTRuMEnTS PG 73 nOTE 23: kEY MAnAGEMEnT pERSOnnEL DiSCLOSuRES PG 74 nOTE 24: COMMiTMEnTS fOR EXpEnDiTuRE PG 75 nOTE 25: EvEnTS OCCuRRinG AfTER REpORTinG DATE PG 75 nOTE 26: REMunERATiOn Of AuDiTORS PG 75 nOTE 27: CASh fLOW infORMATiOn PG 76 nOTE 28: nOn-CASh finAnCinG ACTiviTiES PG 76 nOTE 29: LOSS pER ShARE PG 77 nOTE 30: RELATED pARTY TRAnSACTiOnS PG 79 nOTE 31: pAREnT EnTiTY infORMATiOn PG 79 nOTE 32: BuSinESS COMBinATiOnS – ACquiSiTiOn Of ECLipSE ThERApEuTiCS, inC 45 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES This financial report includes the consolidated financial statements and notes of Bionomics Limited and its controlled entities, the Group. STATEMEnT Of COMpLiAnCE These financial statements are general purpose financial statements which have been prepared in accordance with the Corporations Act 2001, Accounting Standards and interpretations, and comply with other requirements of the law. These financial statements comprise the consolidated financial statements of the Group. The financial statements comprise the consolidated financial statements of the Group. for the purposes of preparing the consolidated financial statements, the Company is a for-profit entity. Accounting Standards include Australian Accounting Standards. Compliance with Australian Accounting Standards ensures that the financial statements and notes of the company and the Group comply with international financial Reporting Standards (ifRS). The financial statements were authorised for issue by the directors on 15 August 2013. BASiS Of pREpARATiOn The consolidated financial statements have been prepared on the basis of historical cost, except for certain non-current assets and financial instruments that are measured at revalued amounts or fair values, as explained in the accounting policies below. historical cost is generally based on the fair values of the consideration given in exchange for assets. All amounts are presented in Australian dollars unless otherwise noted. ADOpTiOn Of nEW AnD REviSED ACCOunTinG STAnDARDS in the current year, the Group has adopted all of the new and revised Standards and interpretations issued by the Australian Accounting Standards Board (the AASB) that are relevant to its operations and effective for the current annual reporting period. STAnDARDS AnD inTERpRETATiOnS in iSSuE nOT YET ADOpTED At the date of the financial statements, the Standards and interpretations listed below were in issue but not yet effective. The reported results and position of the Group will not change on adoption of these pronouncements as currently there are no transactions that will be materially impacted by these pronouncements. Adoption of these pronouncements will however, result in changes to information currently disclosed in the financial statement. The Group does not intend to adopt any of these pronouncements before their effective dates. STANDARD / INTERPRETATION AASB 9 ‘financial instruments’, and the relevant amending standards AASB 10 ‘Consolidated financial Statements’ and AASB 2011-7 ‘Amendments to Australian Accounting Standards arising from the consolidation and Joint Arrangement standards’ AASB 11 ‘Joint Arrangements’ and AASB 2001-7 ‘Amendments to Australian Accounting Standards arising from the consolidation and Joint Arrangements standards’ AASB 12 ‘Disclosure of interests in Other Entities’ and AASB 2011-7 ‘Amendments to Australian Accounting Standards arising from the consolidation and Joint Arrangements standards’ EFFECTIVE FOR ANNUAL REPORTING PERIODS BEGINNING ON OR AFTER EXPECTED TO BE INITIALLY APPLIED IN THE FINANCIAL YEAR ENDING 1 January 2015 30 June 2016 1 January 2013 30 June 2014 1 January 2013 30 June 2014 1 January 2013 30 June 2014 46 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. STANDARD / INTERPRETATION AASB 127 ‘Separate financial Statements’ (2011) and AASB 2011-7 ‘Amendments to Australian Accounting Standards arising from the consolidation and Joint Arrangements standards’ AASB 128 ‘investments in Associates and Joint ventures (2011) and AASB 2011-7 ‘Amendments to Australian Accounting Standards arising from the consolidation and Joint Arrangements standards’ AASB 13 ‘fair value Measurement’ and AASB 2011-8 ‘Amendments to Australian Accounting Standards arising from AASB 13’ AASB 119 ‘Employee Benefits’ (2011) and AASB 2011- 10 ‘Amendments to Australian Accounting Standards arising from AASB 119 (2011)’ AASB 2011-4 ‘Amendments to Australian Accounting Standards to Remove individual key Management personnel Disclosure Requirements’ AASB 2012-2 ‘Amendments to Australian Accounting Standards – Disclosures – Offsetting financial Assets and financial Liabilities’ AASB 2012-3 ‘Amendments to Australian Accounting Standards – Offsetting financial Assets and financial Liabilities’ AASB 2012-5 ‘Amendments to Australian Accounting Standards arising from Annual improvements 2009- 2011 Cycle’ AASB 2012-10 ‘Amendments to Australian Accounting Standards – Transition Guidance and Other Amendments’ EFFECTIVE FOR ANNUAL REPORTING PERIODS BEGINNING ON OR AFTER EXPECTED TO BE INITIALLY APPLIED IN THE FINANCIAL YEAR ENDING 1 January 2013 30 June 2014 1 January 2013 30 June 2014 1 January 2013 30 June 2014 1 January 2013 30 June 2014 1 July 2013 30 June 2014 1 January 2013 30 June 2014 1 January 2014 30 June 2015 1 January 2013 30 June 2014 1 January 2013 30 June 2014 ACCOunTinG pOLiCiES The following significant accounting policies have been adopted in the preparation and presentation of the financial report. (a) Principles of Consolidation The consolidated financial statements comprise the financial statements of Bionomics Limited and its subsidiaries as at 30 June 2013. The financial statements of the subsidiaries are prepared for the same reporting period as the parent entity, using consistent accounting policies where possible. Adjustments are made to bring into line any dissimilar accounting policies that may exist. All intercompany balances and transactions, including unrealised profits arising from intra-group transactions, have been eliminated in full. Subsidiaries are consolidated from the date on which control is obtained and cease to be consolidated from the date on which control ceases. Where there is loss of control of a subsidiary, the consolidated financial statements include the results for the part of the reporting period during which the Company has control. 47 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. (b) Foreign Currency (i) Functional and Presentation Currency items included in the financial statements of each of the Group’s entities are measured using the currency of the primary economic environment in which the entity operates (the functional currency). The consolidated financial statements are presented in Australian dollars which is Bionomics’ functional and presentation currency. (ii) Transactions and Balances foreign currency transactions are translated into the functional currency using the exchange rates prevailing at the dates of the transactions. foreign exchange gains and losses resulting from the settlement of such transactions and from the translation at period-end exchange rates of monetary assets and liabilities denominated in foreign currencies are recognised in profit and loss. Exchange differences on monetary items are recognised in profit or loss in the period in which they arise except for: 3 exchange differences on transactions entered into in order to hedge certain foreign currency risks; and 3 exchange differences on monetary items receivable from or payable to a foreign operation for which settlement is neither planned nor likely to occur (therefore forming part of the net investment in the foreign operation), which are recognised initially in other comprehensive income and reclassified from equity to profit or loss on repayment of the monetary items. (iii) Group Companies The results and financial position of all the Group entities that have a functional currency different from the presentation currency (Australian dollars) are translated into the presentation currency as follows: 3 assets and liabilities for each statement of financial position presented are translated at the closing rate at the date of that statement; 3 income and expenses for each statement of comprehensive income are translated at the average exchange rate for the period; and 3 all resulting exchange differences are recognised in other comprehensive income and accumulated in equity. Goodwill and fair value adjustments arising on the acquisition of a foreign entity are treated as assets and liabilities of the foreign entity and translated at the closing rate. (c) Revenue Recognition interest revenue is recognised on an accruals basis using the effective interest rate method. Service income is recognised when the services are rendered. Rental income is recognised on a straight line basis over the term of the lease. License revenues received in respect of future accounting periods are deferred until the Group has fulfilled its obligations under the terms of the agreement. Where a license agreement has a fixed fee in a non- cancellable contract which permits the licensee to exploit those rights freely and the Group has no remaining obligations to perform, the fee is treated as a sale. Where these conditions have not been met, the license fee is amortised over the life of the licensing agreement. unamortised license fee revenue is recognised in the statement of financial position as deferred income. Research and development work performed for a fee is recognised based on the stage of completion of the research and development. Revenue from a contract to provide services is recognised by reference to the stage of completion of the contract. Milestone payments within license agreements are recognised when the milestone has been achieved. (d) Government Grants and Government Assistance Grants from the government are recognised at their fair value where there is a reasonable assurance that the grant will be received and the Group will comply with all attached conditions. Grants relating to cost reimbursement are recognised in the profit or loss in the period when the costs were incurred. Grants relating to asset purchases are recognised as deferred income on the statement of financial position and transferred to the profit or loss evenly over the expected life of those assets. Government assistance is not recognised until there is reasonable assurance that the Group will be eligible for the assistance and that the income will be received. Government assistance which does not have conditions attached specifically relating to operating activities is recognised as income when it can be reasonably assured that it will be received. Certain forms of government assistance cannot reasonably have a value placed upon them. The nature and extent of the government assistance is disclosed as well as reference to any contingent component that has not been recognised as the end of the reporting period. Research and Development tax incentive is treated as government assistance. 48 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. (e) Income Tax The income tax expense or revenue for the period is the tax payable on the current period’s taxable income based on the national income tax rate for each jurisdiction adjusted by changes in deferred tax assets and liabilities attributable to temporary differences between the tax bases of assets and liabilities and their carrying amounts in the financial statements, and to unused tax losses. Deferred tax assets and liabilities are recognised for temporary differences at the tax rates expected to apply when the assets are recovered or liabilities are settled, based on those tax rates which are enacted or substantively enacted for each jurisdiction. The relevant tax rates are applied to the cumulative amounts of deductible and taxable temporary differences to measure the deferred tax asset or liability. An exception is made for certain temporary differences arising from the initial recognition of an asset or a liability. no deferred tax asset or liability is recognised in relation to these temporary differences if they arose in a transaction, other than a business combination, that at the time of the transaction did not affect either accounting profit or taxable profit or loss. Deferred tax assets are recognised for deductible temporary differences and unused tax losses only if it is probable that future taxable amounts will be available to utilise those temporary differences and losses. Current and deferred tax balances attributable to amounts recognised directly in equity are also recognised directly in equity. (i) Tax Consolidation Legislation Bionomics and its wholly-owned Australian controlled entities have implemented the tax consolidation legislation effective 31 December 2005. The head entity, Bionomics, and the controlled entities in the tax consolidated group account for their own current and deferred tax amounts. These tax amounts are measured as if each entity in the tax consolidated group continues to be a stand-alone taxpayer in its own right. in addition to its own current and deferred tax amounts, Bionomics also recognises the current tax liabilities (or assets) and the deferred tax assets arising from unused tax losses and unused tax credits assumed from controlled entities in the tax consolidated group. Assets or liabilities arising under tax funding agreements with the tax consolidated entities are recognised as amounts receivable from or payable to other entities in the group. Any difference between the amounts assumed and amounts receivable or payable under the taxfunding agreement are recognised as a contribution to (or distribution from) wholly-owned tax consolidated entities. (f) Business Combinations Acquisitions of businesses are accounted for using the acquisition method. The consideration transferred in a business combination is measured at fair value which is calculated as the sum of the acquisition-date fair values of assets transferred by the Group, liabilities incurred by the Group to the former owners of the acquiree and the equity instruments issued by the Group in exchange for control of the acquiree. Acquisition-related costs are recognised in profit or loss as incurred. At the acquisition date, the identifiable assets acquired and the liabilities assumed are recognised at their fair value, except that: 3 deferred tax assets or liabilities and assets or liabilities related to employee benefit arrangements are recognised and measured in accordance with AASB 112 ‘income Taxes’ and AASB 119 ‘Employee Benefits’ respectively; 3 liabilities or equity instruments related to share-based payment arrangements of the acquiree or share-based payment arrangements of the Group entered into to replace share-based payment arrangements of the acquiree are measured in accordance with AASB 2 ‘Share-based payment’ at the acquisition date; and 3 assets (or disposal groups) that are classified as held for sale in accordance with AASB 5 ‘noncurrent Assets held for Sale and Discontinued Operations’ are measured in accordance with that Standard. Goodwill is measured as the excess of the sum of the consideration transferred, the amount of any non- controlling interests in the acquiree, and the fair value of the acquirer’s previously held equity interest in the acquiree (if any) over the net of the acquisition-date amounts of the identifiable assets acquired and the liabilities assumed. if, after reassessment, the net of the acquisition-date amounts of the identifiable assets acquired and liabilities assumed exceeds the sum of the consideration transferred, the amount of any non-controlling interests in the acquiree and the fair value of the acquirer’s previously held interest in the acquiree (if any), the excess is recognised immediately in profit or loss as a bargain purchase gain. non-controlling interests that are present ownership interests and entitle their holders to a proportionate share of the entity’s net assets in the event of liquidation may be initially measured either at fair value or at the non-controlling interests’ proportionate share of the recognised amounts of the acquiree’s identifiable net 49 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. assets. The choice of measurement basis is made on a transaction-by-transaction basis. Other types of non- controlling interests are measured at fair value or, when applicable, on the basis specified in another Standard. Where the consideration transferred by the Group in a business combination includes assets or liabilities resulting from a contingent consideration arrangement, the contingent consideration is measured at its acquisition-date fair value. Changes in the fair value of the contingent consideration that qualify as measurement period adjustments are adjusted retrospectively, with corresponding adjustments against goodwill. Measurement period adjustments are adjustments that arise from additional information obtained during the ‘measurement period’ (which cannot exceed one year from the acquisition date) about facts and circumstances that existed at the acquisition date. The subsequent accounting for changes in the fair value of contingent consideration that do not qualify as measurement period adjustments depends on how the contingent consideration is classified. Contingent consideration that is classified as equity is not remeasured at subsequent reporting dates and its subsequent settlement is accounted for within equity. Contingent consideration that is classified as an asset or liability is remeasured at subsequent reporting dates in accordance with AASB 139, or AASB 137 ‘provisions, Contingent Liabilities and Contingent Assets’, as appropriate, with the corresponding gain or loss being recognised in profit or loss. Where a business combination is achieved in stages, the Group’s previously held equity interest in the acquiree is remeasured to fair value at the acquisition date (ie the date when the Group attains control) and the resulting gain or loss, if any, is recognised in profit or loss. Amounts arising from interests in the acquiree prior to the acquisition date that have previously been recognised in other comprehensive income are reclassified to profit or loss where such treatment would be appropriate if that interest were disposed of. if the initial accounting for a business combination is incomplete by the end of the reporting period in which the combination occurs, the Group reports provisional amounts for the items for which the accounting is incomplete. Those provisional amounts are adjusted during the measurement period (see above), or additional assets or liabilities are recognised, to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the amounts recognised as of that date. (g) Impairment of Tangible and Intangible Assets Other Than Goodwill At the end of each reporting period, the Group reviews the carrying amounts of its tangible and intangible assets to determine whether there is any indication that those assets have suffered an impairment loss. if any such indication exists, the recoverable amount of the asset is estimated in order to determine the extent of the impairment loss (if any). Where it is not possible to estimate the recoverable amount of an individual asset, the Group estimates the recoverable amount of the cash-generating unit to which the asset belongs. Where a reasonable and consistent basis of allocation can be identified, corporate assets are also allocated to individual cash-generating units, or otherwise they are allocated to the smallest group of cash-generating units for which a reasonable and consistent allocation basis can be identified. intangible assets with indefinite useful lives are tested for impairment at least annually, and whenever there is an indication that the asset may be impaired. Recoverable amount is the higher of fair value less costs to sell and value in use. in assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset for which the estimates of future cash flows have not been adjusted. if the recoverable amount of an asset (or cash-generating unit) is estimated to be less than its carrying amount, the carrying amount of the asset (or cash-generating unit) is reduced to its recoverable amount. An impairment loss is recognised immediately in profit or loss, unless the relevant asset is carried at a revalued amount, in which case the impairment loss is treated as a revaluation decrease. Where an impairment loss subsequently reverses, the carrying amount of the asset (or cash-generating unit) is increased to the revised estimate of its recoverable amount, but so that the increased carrying amount does not exceed the carrying amount that would have been determined had no impairment loss been recognised for the asset (or cash-generating unit) in prior years. A reversal of an impairment loss is recognised immediately in profit or loss, unless the relevant asset is carried at a revalued amount, in which case the reversal of the impairment loss is treated as a revaluation increase. 50 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. (h) Cash and Cash Equivalents Cash and cash equivalents includes cash on hand, deposits held at call with financial institutions, other short term, highly liquid investments with original maturities of three months or less that are readily convertible to known amounts of cash and which are subject to an insignificant risk of changes in value and bank overdrafts. Bank overdrafts are shown within borrowings in current liabilities on the statement of financial position. (i) Trade Receivables All trade debtors are recognised at the fair value of amounts receivable as they are due for settlement no more than 30 days from the date of recognition. Collectability of trade debtors is reviewed on an ongoing basis. Debts which are known to be uncollectible are written off. A provision for doubtful debts is raised when some doubt as to collection exists. The amount of the provision is the difference between the carrying amount and the present value of future cash flows, discounted at the effective interest rate. The amount of the provision is recognised in profit or loss. (j) Inventories Raw materials and stores are stated at the lower of cost and net realisable value. (k) Property, Plant and Equipment Land and buildings are shown at fair value, based on periodic, valuations by external independent valuers, less subsequent depreciation for buildings. Any accumulated depreciation at the date of revaluation is eliminated against the gross carrying amount of the asset and the net amount is restated to the revalued amount of the asset. All other plant and equipment are brought to account at cost less any accumulated depreciation or any recognised impairment losses, where applicable. The directors have taken reasonable steps to ensure that property, plant and equipment are not carried at amounts that are in excess of their recoverable amounts at balance date. increases in the carrying amounts arising on revaluation of land and buildings are credited, net of tax, to other comprehensive income. To the extent that the increase reverses a decrease previously recognised in profit or loss, the increase is first recognised in profit or loss. Decreases that reverse previous increases of the same asset are first charged against revaluation reserves directly in equity to the extent of the remaining reserve attributable to the asset; all other decreases are charged to profit or loss. Depreciation on revalued buildings is charged to profit and loss. On the subsequent sale or retirement of a revalued property, the attributable revaluation surplus remaining in the revaluation reserve, net of tax, is transferred directly to retained earnings. Land is not depreciated. The depreciable amount of all fixed assets is depreciated over their useful lives commencing from the time the asset is held ready for use, on either a prime or diminishing value basis depending on the type of asset. The gain or loss on disposal of all fixed assets is determined as the difference between the carrying amount of the asset at the time of disposal and the proceeds of disposal and is included in profit or loss in the year of disposal. The depreciation rates for each class of depreciable assets are: 3 administrative plant & equipment 3 scientific plant & equipment 3 refrigeration plant and equipment 20 – 40% 20 – 40% 33% (l) Financial Assets financial assets are classified into the following specified categories: financial assets ‘at a fair value through profit or loss’ (fvTpL), ‘held-to-maturity’ investments, ‘available-for-sale’ (AfS) financial assets and ‘loans and receivables’. The classification depends on the nature and purpose of the financial assets and is determined at the time of initial recognition. All regular way purchases or sales of financial assets are recognised and derecognised on a trade date basis. Regular way purchases or sales are purchases or sales of financial assets that require delivery of assets within the time frame established by regulation or convention in the marketplace. (i) Loans and Receivables Trade receivables, loans and other receivables that have fixed or determinable payments that are not quoted in an active market are classified as ‘loans and receivables’. Loans and receivables are measured at amortised cost using the effective interest method less impairment. interest income is recognised by applying the effective interest rate. (ii) Impairment of Financial Assets financial assets, other than those at fair value through profit or loss, are assessed for indicators of impairment at each reporting date. financial assets are impaired where there is objective evidence that as a result of one or more events that occurred after the initial recognition of the financial asset the estimated future cash flows of the investment have been impacted. 51 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. for financial assets carried at amortised cost, the amount of the impairment is the difference between the asset’s carrying amount and the present value of estimated future cash flows, discounted at the original effective interest rate. The carrying amount of financial assets including uncollectible trade receivables is reduced by the impairment loss through the use of an allowance account. Subsequent recoveries of amounts previously written off are credited against the allowance account. Changes in the carrying amount of the allowance account are recognised in profit or loss. (m) Intangible Assets (i) Intellectual Property Acquired intellectual property is recognised as an asset at cost and amortised over its useful life. intellectual property with a finite life is amortised on a straight line basis over that life. intellectual property with an indefinite useful life is subjected to an annual impairment review. There is currently no intellectual property with an indefinite life. Current useful life of all existing intellectual property is in the range of 5 to 20 years. The assets’ residual values and useful lives are reviewed, and adjusted if appropriate, at each balance date. (ii) Goodwill Goodwill is initially recorded at the amount by which the purchase price for a business or for an ownership interest in a controlled entity exceeds the fair value attributed to its net identifiable assets, including any associated deferred tax assets and liabilities, at date of acquisition. Goodwill on acquisitions of subsidiaries is included in intangible assets. Goodwill acquired in business combinations is not amortised. instead, goodwill is tested for impairment annually and is carried at cost less accumulated impairment losses. Gains and losses on the disposal of an entity include the carrying amount of goodwill relating to the entity sold. Goodwill is allocated to cash generating units for the purpose of impairment testing. (n) Research and Development Expenditure on research activities, undertaken with the prospect of obtaining new scientific or technical knowledge and understanding, is recognised as an expense when it is incurred. (o) Trade and Other Payables These amounts represent liabilities for goods and services provided to the Group prior to the end of financial year which are unpaid. The amounts are unsecured and are usually paid within 45 days of recognition. (p) Employee Benefits (i) Wages and Salaries, Annual Leave and Sick Leave Liabilities for wages and salaries, including non- monetary benefits and annual leave in respect of employees’ services up to the reporting date and expected to be settled within 12 months of the reporting date are recognised in liabilities and are measured at the amounts expected to be paid when the liabilities are settled. Liabilities for non- accumulating sick leave are recognised when the leave is taken at the rates paid. (ii) Long Service Leave The liability for long service leave is recognised in the provision for employee benefits in respect of services provided by employees up to the reporting date and measured as the present value of expected future payments to be made. (iii) Superannuation Contributions are made to employee superannuation funds and are charged as expenses when incurred. These contributions are made to external superannuation funds and are not defined benefits programs. Consequently there is no exposure to market movements on employee superannuation liabilities or entitlements. (iv) Share-based Payments Share-based compensation benefits are provided to employees via the Bionomics ESOp and an Employee Share plan. The fair value of shares issued to employees for no cash consideration under the Employee Share plan is recognised as an employee benefits expense with a corresponding increase in equity. The fair value is measured at grant date and recognised over the period during which the employees become unconditionally entitled to the shares. The Bionomics ESOp was approved by the Board and shareholders in 2011. Staff eligible to participate in the plan are those who have been a full-time or part- time employee of the Company for a period of not less than six months or a director of the Company. Options are granted under the plan for no consideration and vest equally over five years, unless they are bonus options which vest immediately. 52 NOTE 1: SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES CONT. The amounts disclosed as remuneration relating to options are the assessed fair values at grant date of those options allocated equally over the period from grant date to vesting date. fair values at grant date are independently determined using a Black- Scholes option pricing model that takes into account the exercise price, the term of the option, the vesting and performance criteria, the impact of dilution, the non-tradeable nature of the option, the share price at grant date, expected price volatility of the underlying share, the expected dividend yield and the risk-free interest rate for the term of the option. Share options that have been issued, but due to having performance criteria, have not yet been granted or vested, are required to have their fair value estimated at the end of the reporting period and recognised as an expense relating to the period in which the services were performed. (q) Borrowings (other financial liabilities) Borrowings are initially recognised at fair value, net of transaction costs incurred. Borrowings are subsequently measured at amortised cost. Any difference between the proceeds (net of transaction costs) and the redemption amount is recognised in profit or loss over the period of the borrowings using the effective interest method. Borrowings are classified as current liabilities unless the Group has an unconditional right to defer settlement of the liability for at least 12 months after the balance sheet date. (r) Borrowing Costs Borrowing costs incurred for the construction of any qualifying asset are capitalised during the period of time that is required to complete and prepare the asset for its intended use or sale. Other borrowing costs are expensed. (s) Leases Leases of property, plant and equipment where the Group has substantially all the risks and rewards of ownership are classified as finance leases. finance leases are capitalised at the lease’s inception at the lower of the fair value of the leased property and the present value of the minimum lease payments. The corresponding rental obligations, net of finance charges, are included in other long term payables. Each lease payment is allocated between the liability and finance charges so as to achieve a constant rate on the finance balance outstanding. The interest element of the finance cost is charged to the profit or loss over the lease period so as to produce a constant periodic rate of interest on the remaining balance of the liability for each period. The property, plant and equipment acquired under finance leases is depreciated over the shorter of the asset’s useful life and the lease term. Leases in which a significant portion of the risks and rewards of ownership are retained by the lessor are classified as operating leases. payments made under operating leases (net of any incentives received from the lessor) are charged to profit or loss on a straight-line basis over the period of the lease. Lease income from operating leases is recognised in income on a straight-line basis over the lease term. (t) Contributed Equity Ordinary shares are classified as equity. incremental costs directly attributable to the issue of new shares or options, or for the acquisition of a business, are deducted directly from equity. (u) Earnings/(Loss) per Share (i) Basic Earnings/(Loss) per Share Basic earnings/(loss) per share is calculated by dividing the profit/(loss) after income tax attributable to equity holders of the company, excluding any costs of servicing equity other than ordinary shares, by the weighted average number of ordinary shares outstanding during the year, adjusted for bonus elements in ordinary shares issued during the year. (ii) Diluted Earnings/(Loss) per Share Diluted earnings/(loss) per share adjusts the figures used in the determination of basic earnings per share to take into account the after income tax effect of interest and other financing costs associated with dilutive potential ordinary shares and the weighted average number of shares assumed to have been issued for no consideration in relation to options. (v) Goods and Services Tax (GST) Revenues, expenses and assets are recognised net of the amount of associated GST, unless the GST incurred is not recoverable from the taxation authority. in this case it is recognised as part of the cost of acquisition of the asset or as part of the expense. Receivables and payables are stated inclusive of the amount of GST receivable or payable. The net amount of GST recoverable from, or payable to, the taxation authority is included with other receivables or payables in the statement of financial position. Cash flows are presented on a gross basis. The GST component of cash flow arising from investing or financing activities which are recoverable from, or payable to the taxation authority, are presented as operating cash flow. 53 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 2: CRITICAL ACCOUNTING ESTIMATES AND JUDGEMENTS in the application of the Group’s accounting policies, which are described in note 1, the directors are required to make judgements, estimates and assumptions about the carrying amounts of assets and liabilities that are not readily apparent from other sources. The estimates and associated assumptions are based on historical experience and other factors that are considered to be relevant. Actual results may differ from these estimates. The estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognised in the period in which the estimate is revised if the revision affects only that period or in the period of the revision and future periods if the revision affects both current and future periods. (a) Critical Accounting Estimates and Judgements The Group makes estimates and assumptions concerning the future. The resulting accounting estimates will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities are discussed below. Estimated Impairment of Goodwill and Intangibles Determining whether goodwill and intangibles are impaired requires an estimation of the value in use of the cash- generating units to which goodwill has been allocated. The value in use calculation requires the entity to estimate the future cash flows expected to arise from the cash-generating units and a suitable discount rate in order to calculate present value. The carrying amount of goodwill at balance date was $5,147,990 (2012: $5,147,990). The total carrying amount of intangibles at balance date was $22,052,744 (2012: $8,520,206). no impairment costs have been recognised in the current or previous financial years. Valuation of Intangible Asset and Contingent Consideration on Acquisition of Eclipse Therapeutics, Inc in accordance with Accounting Standard AASB 3 ‘Business Combinations’ and as detailed in note 32, the Company has provisionally determined, based on the directors’ best estimate the likely fair value of the consideration transferred, intangible assets (including, but not limited to intellectual property, goodwill and deferred tax assets) which may be amended when further information to support these values is obtained. NOTE 3: SEGMENT INFORMATION information reported to the chief operating decision maker for the purposes of resource allocation and assessment of segment performance focuses on the nature of work processes performed. The Group’s reportable segments under AASB 8 are: 3 Drug discovery 3 Drug development 3 Contract services Drug discovery is the creation and ongoing testing of compounds to determine the best compound that matches the product profile. Drug development is defined as the ongoing testing including clinical trials of the best compound with a view to commercialisation of the compound. Contract services is the provision of scientific services on a fee for service basis to both external and internal customers. 54 NOTE 3: SEGMENT INFORMATION CONT. information regarding these segments is presented as follows: (a) Segment Revenues and Results The following is an analysis of the Group’s revenue and results by reportable operating segment for the periods under review: Drug discovery Drug development Contract services SEGMENT REVENUE YEAR ENDED SEGMENT PROFIT YEAR ENDED 30 JUNE 2013 $ 30 JUNE 2012 $ 30 JUNE 2013 $ 30 JUNE 2012 $ 345,044 1,088,479 (5,643,324) (1,379,381) 1,452,602 3,555,621 (3,640,544) (203,030) 3,076,716 1,801,887 833,057 8,024 4,874,362 6,445,987 (8,450,811) (1,574,387) Less: intercompany revenue included in contract services (2,040,591) (917,543) - - investment & other revenue 890,398 1,306,265 890,398 1,306,265 3,724,169 6,834,709 (7,560,413) (268,122) unallocated financing costs Central administration costs Loss before income tax (continuing operations) (68,703) (56,831) (2,334,059) (3,003,943) (9,963,175) (3,328,896) Revenue reported above for Contract services includes intersegment sales. There were no intersegment sales for the other reportable segments. Segment profit represents the result for each segment without allocation of central administration costs and investment and other revenue. financing costs are allocated to segments with a residual amount being unallocated financing costs. (b) Segment Assets and Liabilities The following is an analysis of the Group’s assets and liabilities by reportable operating segment: ASSETS Drug discovery Drug development Contract services unallocated assets Total assets LIABILITIES Contract services (excluding intercompany liabilities) unallocated liabilities Total liabilities 30 JUNE 2013 $ 30 JUNE 2012 $ 20,260,167 10,131,324 825,460 3,093,726 8,578,963 1,712,836 31,216,951 13,385,525 22,394,141 17,716,663 53,611,092 31,102,188 835,940 855,097 11,368,169 4,347,974 12,204,109 5,203,071 Assets used jointly by reporting segments are allocated on the basis of employee numbers of the individual reportable segment. The Board receive information on liabilities for the Group as a whole as well as liability information for the Contract services segment. 55 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 3: SEGMENT INFORMATION CONT. The Board receive information on non-current assets for the Group as a whole as well as non-current asset information for the Contract services segment. Additions to non-current assets: Contract services unallocated (c) Other Segment Information The segment result above has been determined after including the following items: 30 JUNE 2013 $ 30 JUNE 2012 $ 15,489 288,600 304,089 20,173 628,623 648,796 Drug discovery Drug development Contract services unallocated INTEREST EXPENSE YEAR ENDED DEPRECIATION AND AMORTISATION YEAR ENDED 30 JUNE 2013 $ 30 JUNE 2012 $ 30 JUNE 2013 $ 30 JUNE 2012 $ - - 9,495 68,703 78,198 - - 7,619 56,831 64,450 770,673 248,597 203,579 22,966 1,245,815 208,887 240,388 213,275 34,167 696,717 (d) Revenue from Major Products and Services The following is an analysis of the Group’s external revenue from its major products and services: Contract services Collaboration income interest Other (note 4) 30 JUNE 2013 $ 30 JUNE 2012 $ 1,036,125 1,162,117 644,626 881,301 884,344 4,254,715 1,035,947 659,703 3,724,169 6,834,709 (e) Geographical Information The Group operates in three geographical areas, Australia, france and united States of America. The Group’s external revenue and information about its non-current assets* by geographical segment are detailed below: Australia france uSA REVENUE FROM EXTERNAL CUSTOMERS YEAR ENDED NON-CURRENT ASSETS* YEAR ENDED 30 JUNE 2013 $ 30 JUNE 2012 $ 30 JUNE 2013 $ 30 JUNE 2012 $ 2,688,044 1,036,125 - 5,950,365 22,054,855 8,577,038 884,344 - 609,491 231,248 716,415 - 3,724,169 6,834,709 22,895,594 9,293,453 *non-current assets excluding financial instruments and deferred tax assets. 56 NOTE 3: SEGMENT INFORMATION CONT. (f) Information about Major Customers included in revenues for Drug discovery are revenues of $384,170 (2012: $932,598) from one party and in Drug development $1,394,944 (2012: $3,341,346) from one party. no other customer contributed 10% or more to the Group’s revenue for both 2013 and 2012. NOTE 4: REVENUE AND OTHER INCOME Revenue Revenue from rendering of services Royalties Collaboration income interest income Rent income Other revenue Other income foreign Government grant R&D Tax incentive 2013 $ 2012 $ 1,032,144 57,658 856,200 135,866 1,162,117 4,254,715 644,626 222,561 605,063 1,035,947 282,068 269,913 3,724,169 6,834,709 - 2,837 8,101,787 3,100,000 8,101,787 3,102,837 potentially eligible overseas expenditure is awaiting Ausindustry approval pending review of applications submitted prior to 30 June 2013 which is not included as part of the estimate of R&D incentive for year ended 30 June 2013. The 2013 balance includes an amount of $1,101,787, which was excluded for the year ended 30 June 2012, as overseas applications for eligible expenditure were pending and approved subsequent to the year end. There are no unfulfilled conditions or other contingencies attaching to these grants. NOTE 5: EXPENSES Loss before income tax benefit includes the following specific expenses: Financing costs - interest expense on bank and other loans - interest obligations under finance leases Depreciation - Administrative plant and equipment - Scientific plant and equipment Amortisation of non-current assets - intellectual property Rental expense on operating leases - Minimum lease payments Employment benefit expenses of: - Wages and salaries - Superannuation - Share-based payments Loss on disposal of assets - plant and equipment foreign currency loss/(gain) 2013 $ 2012 $ 41,684 36,514 78,198 37,817 200,088 237,905 45,125 19,325 64,450 34,616 134,368 168,984 1,007,910 527,733 927,682 894,252 5,092,005 3,403,058 496,730 136,908 497,457 324,999 5,725,643 4,225,514 184 5,824 836,584 (65,321) 57 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 6: INCOME TAXES (a) Income Tax Recognised in Profit or Loss CURRENT TAX Current tax benefit in respect of the current year DEFERRED TAX Deferred tax recognised in current year Total income tax expense/(benefit) (b) Reconciliation to Accounting Loss Loss from continuing operations Tax at the Australian tax rate of 30% (2012: 30%) Tax effect of non-deductible / non-assessable amounts - Amortisation of intangibles - foreign exchange reversed on consolidation - Exempt income from government assistance - Entertainment - Share-based payments - Research and development expenditure Effect of different tax rates in other jurisdictions Effect on unused tax losses, not previously recognised, in the current period Adjustment to prior year unused tax losses Deferred tax assets not recognised in current period Tax benefit of research and development credit in france (c) Current Tax Balances CURRENT TAX ASSETS Tax refund receivable 2013 $ 2012 $ (32,490) (121,993) (32,490) (121,993) 70,665 70,665 (70,665) (70,665) 38,175 (192,658) (9,963,175) (3,328,896) (2,988,953) (998,669) 101,893 101,893 52,678 (16,292) (2,430,536) (930,000) 249 1,393 41,072 116,940 4,661,493 2,033,747 13,928 (7,060) 1,009,323 (1,705,451) (390,482) 1,287,213 - 45,621 (32,490) (121,993) 38,175 (192,658) 36,648 360,386 36,648 360,386 58 OPENING BALANCE $ CHARGED TO INCOME $ CHARGED TO EQUITY $ OTHER COMPRE- HENSIVE INCOME $ CLOSING BALANCE $ 262,381 (32,133) (10,870) 10,870 (2,655) (22,451) 184,318 334,592 218,383 10,395 236,244 1,210,337 (2,327) 4,027 (38,419) 32,296 - 3,150 41,914 19,378 19,854,143 (68,636) 213,015 (151,519) 20,067,158 (220,155) 21,206,830 (130,112) 70,665 (70,665) 258,857 3,524 - (10,870) (28,801) (28,213) 222,737 256,493 218,383 26,146 5,762 (38,419) 78,099 - 60,587 (50,192) 204,673 1,164,716 31,571 45,621 21,496,973 (1,642,830) 213,015 - 21,709,988 (1,642,830) 22,874,704 (1,667,874) - 70,665 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 230,248 - (4,982) (18,424) 145,899 366,888 218,383 13,545 278,158 1,229,715 19,785,507 61,496 19,847,003 21,076,718 - 262,381 (10,870) (2,655) (22,451) 184,318 334,592 218,383 10,395 236,244 1,210,337 19,854,143 213,015 20,067,158 21,206,830 70,665 NOTE 6: INCOME TAXES CONT. (d) Deferred Tax Balances 2013 Loans and receivables Other financial assets prepayments / accrued income pp & E Share issue expenses intangible patents and trademarks Other intangibles Accrued expenses Employee entitlements Unused tax losses Revenue Withholding tax not recognised in current year net balance 2012 Loans and receivables Other financial assets prepayments / accrued income pp & E Share issue expenses intangible patents and trademarks Other intangibles Accrued expenses Employee entitlements Unused tax losses Revenue Withholding tax not recognised in current year net balance 59 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 6: INCOME TAXES CONT. (e) Unrecognised Temporary Differences (including Tax Losses) The following deferred tax assets have not been brought to account as assets: unused revenue tax losses (no set expiry period) Deductible temporary differences (no set expiry period) unused foreign withholding tax credits (expire July 2013) 2013 $ 2012 $ 19,785,507 19,783,478 1,229,715 1,210,337 61,496 213,015 21,076,718 21,206,830 (f) Tax Consolidation Relevance of tax consolidation to the group The Company and all its wholly-owned Australian resident entities are part of a tax-consolidated group under Australian taxation law. Bionomics is the head entity in the tax-consolidated group. Tax expense/benefit, deferred tax liabilities and deferred tax assets arising from temporary differences of the members of the tax-consolidated group are recognised in the separate financial statements of the members of the tax-consolidated group using the ‘separate taxpayer within group’ approach by reference to the carrying amounts in the separate financial statements of each entity and the tax values applying under tax consolidation. Current tax liabilities and assets and deferred tax assets arising from unused tax losses and relevant tax credits of the members of the tax-consolidated group are recognised by the Company (as head entity in the tax-consolidated group). NOTE 7: CASH AND CASH EQUIVALENTS CURRENT Cash at the end of the financial year as shown in the statements of cash flows is reconciled to items in the balance sheet as follows: Cash at bank and on hand Deposits at call Restricted deposits at call are held as security and are not available for use (see note 16): 3 Commercial bill line 3 Rental guarantee 3 Lease line $550,000 $384,000 $215,000 NOTE 8: TRADE AND OTHER RECEIVABLES CURRENT Trade receivables Allowance for doubtful debts Other receivables 2013 $ 2012 $ 5,187,222 3,207,319 17,264,867 14,129,290 22,452,089 17,336,609 2013 $ 2012 $ 430,121 233,985 - 430,121 275,601 705,722 - 233,985 177,432 411,417 in determining the recoverability of a trade receivable, the Group considers any change in the credit quality of the trade receivable from the date credit was initially granted up to the reporting date. The directors believe that there is no credit provision required at 30 June 2013. 60 NOTE 9: OTHER FINANCIAL ASSETS 2013 $ 2012 $ Financial Assets Carried at Fair Value Through Profit or Loss (FVTPL) held for trading derivatives that are not designated in hedge accounting relationships - 36,232 NOTE 10: INVENTORIES CURRENT Raw materials NOTE 11: OTHER ASSETS CURRENT prepayments Accrued interest and grants receivable / government assistance (note 4) NOTE 12: SUBSIDIARIES Details of the Group’s subsidiaries at the end of the reporting period are as follows: 2013 $ 2012 $ 98,526 135,284 2013 $ 2012 $ 422,513 349,290 7,000,000 3,108,852 7,422,513 3,458,142 PERCENTAGE OWNED % ENTITY Head entity PRINCIPAL ACTIVITY COUNTRY OF INCORPORATION 2013 2012 Bionomics Limited Research and Development Australia Subsidiaries of Bionomics Limited: neurofit SAS Contract Research Organisation france iliad Chemicals pty Limited Asset owner Australia Bionomics inc Research and Development united States n/A 100 100 100 n/A 100 100 100 61 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 13: PROPERTY, PLANT AND EQUIPMENT Gross carrying amount at 1 July 2011 Additions Disposals foreign currency exchange differences Gross carrying amount at 30 June 2012 Additions Disposals foreign currency exchange differences ADMINISTRATIVE PLANT & EQUIPMENT $ SCIENTIFIC PLANT & EQUIPMENT $ REFRIGERATION PLANT & EQUIPMENT $ TOTAL $ 415,001 34,099 (42,423) (13,777) 392,900 29,158 (2,663) 22,743 1,705,309 87,500 2,207,810 614,697 (58,891) (7,002) 2,254,113 274,931 (3,982) 11,342 - - - 648,796 (101,314) (20,779) 87,500 2,734,513 - - - 304,089 (6,645) 34,085 Gross carrying amount at 30 June 2013 442,138 2,536,404 87,500 3,066,042 Accumulated depreciation amount at 1 July 2011 Disposals foreign currency exchange differences Depreciation (note 5) Accumulated depreciation amount at 30 June 2012 Disposals foreign currency exchange differences Depreciation (note 5) Accumulated depreciation amount at 30 June 2013 Net Carrying Amounts 30 June 2012 Net Carrying Amounts 30 June 2013 (311,887) (1,505,719) (87,500) (1,905,106) 39,229 13,128 (34,616) 56,262 4,205 (134,368) - - - 95,491 17,333 (168,984) (294,146) (1,579,620) (87,500) (1,961,266) 2,596 (19,120) (37,817) 3,865 (11,362) (200,088) - - - 6,461 (30,482) (237,905) (348,487) (1,787,205) (87,500) (2,223,192) 98,754 93,651 674,493 749,199 - - 773,247 842,850 nOn-CuRREnT ASSETS pLEDGED AS SECuRiTY Refer to note 16 for information on non-current assets pledged as security by the Company. 62 NOTE 14: INTANGIBLE ASSETS Gross carrying amount at 1 July 2011 foreign currency exchange differences GOODWILL $ 5,147,990 INTELLECTUAL PROPERTY $ TOTAL $ 6,806,632 11,954,622 - (151,550) (151,550) Gross carrying amount at 30 June 2012 5,147,990 6,655,082 11,803,072 Additions (note 32) foreign currency exchange differences - - 12,703,228 12,703,228 2,044,613 2,044,613 Gross carrying amount at 30 June 2013 5,147,990 21,402,923 26,550,913 Accumulated amortisation amount at 1 July 2011 foreign currency exchange differences Amortisation (note 5) Accumulated amortisation amount at 30 June 2012 foreign currency exchange differences Amortisation Accumulated amortisation amount at 30 June 2013 Net carrying amount 30 June 2012 Net carrying amount 30 June 2013 All intangible assets are held in the consolidated entity. (a) Intellectual Property - - - - - - - (2,834,442) (2,834,442) 79,309 (527,733) 79,309 (527,733) (3,282,866) (3,282,866) (207,393) (1,007,910) (207,393) (1,007,910) (4,498,169) (4,498,169) 5,147,990 5,147,990 3,372,216 8,520,206 16,904,754 22,052,744 The intellectual property includes the company’s Multicore® technology, its BnC105 compound, its BnC101 compound and its kv1.3 compound with carrying amounts ranging from $0.7m to $14.5m. Each item is carried at its fair value as at its date of acquisition, less accumulated amortisation charges. The remaining amortisation periods for each item are between 5 and 20 years. (b) Impairment Tests Management tests annually whether goodwill or indefinite life intangibles have suffered any impairment, in accordance with the accounting policy stated in note 1(m)(i) and (m)(ii). impairment testing is performed on each of the cash generating units, which are the same as the reporting segments identified in note 3. Determining whether goodwill or intangibles are impaired requires an estimation of the value in use of the cash generating units to which goodwill or indefinite life intangibles have been allocated. The value in use calculation requires the entity to estimate the future cash flows expected to arise from the cash generating unit and a suitable discount rate in order to calculate present value. These discount rates range between 15% for lower risk cash flows and 25% for higher risk cash flows. Allocation of Goodwill to CGU’s The carrying amount of goodwill was allocated to the following CGu’s: Drug discovery Drug development Contract services 2013 $ - 2012 $ - 5,147,990 5,147,990 - - 63 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 14: INTANGIBLE ASSETS CONT. DRuG DiSCOvERY The recoverable amount of this CGu is determined based on a value in use calculation which uses cash flow projections based on standard industry agreements for drug compounds within the cash generating unit over a period of up to 21 years covering drug discovery, drug development, approval and marketing and a discount rate of 25% per annum (2012: 15% per annum). The cash flow projections are weighted based on the probability of realising projected milestone and royalties payments. Management believes that the application of discounted cash flows of standard industry agreements for drug compounds is reasonable to be applied to other compounds within the CGu at their respective development phases. Management believes that any reasonably possible change in the key assumptions on which recoverable amount is based would not cause the aggregate carrying amount to exceed the aggregate recoverable amount of the CGu. no growth rates have been included in the forecast. As the full development lifecycle has been taken into account with the cashflows, no terminal value has been used. DRuG DEvELOpMEnT The recoverable amount of this CGu is also determined based on a value in use calculation which uses cash flow projections based on standard industry agreements for drug compounds within the cash generating unit over a period of ten years covering drug development, approval and marketing, and a discount rate of 25% per annum (2012: 15% per annum). The cash flow projections are weighted based on the probability of realising projected milestone and royalties payments. Management believes that the application of discounted cash flows of standard industry agreements for one drug compound is reasonable to be applied to other compounds within the CGu at their respective development phases. Management believes that any reasonably possible change in the key assumptions on which recoverable amount is based would not cause the aggregate carrying amount to exceed the aggregate recoverable amount of the CGu. no growth rates have been included in the forecast. As the full development lifecycle has been taken into account with the cashflows, no terminal value has been used. COnTRACT SERviCES The recoverable amount of this CGu is determined based on a value in use calculation which uses cash flow projections prepared by management over a five year period with an appropriate terminal value using a discount rate of 15%. Annual growth rates of 0% (2012: 0%) per annum have been assumed in determining the cash flow projections. Management believes that any reasonably possible change in the key assumptions on which recoverable amount is based would not cause the aggregate carrying amount to exceed the aggregate recoverable amount of the CGu. NOTE 15: TRADE AND OTHER PAYABLES CURRENT Trade payables Accrued expenses NON-CURRENT Other payables 2013 $ 2012 $ 3,272,242 1,990,975 1,011,367 837,245 4,283,609 2,828,220 306,410 272,855 The average credit period on purchases of goods is 45 days. no interest is paid on the trade payables. The Group has financial risk management policies in place to ensure that all payables are paid within the credit timeframe. NOTE 16: BORROWINGS SECURED – AT AMORTISED COST Bank overdrafts finance lease liabilities (i) Equipment mortgage (ii) Bank loan (iii) Disclosed in the financial statements as: Current liabilities non-current liabilities 64 2013 $ - 442,941 87,594 550,000 2012 $ 48,036 578,725 - 550,000 1,080,535 1,176,761 680,376 400,159 732,819 443,942 1,080,535 1,176,761 (i) the lease lines are secured by the leased scientific equipment (refer note 24) and have an average interest rate of per annum 7.11% (2012: 7.14% per annum) and terms of three to five years. (ii) equipment mortgage for uS-based equipment with an interest rate of 3.25% and a three year term. (iii) the rolling commercial bill line is secured by a restricted deposit at call of $550,000 (2012: $550,000). The unused facilities available at 30 June 2013 of the Group’s bank overdraft is $56,980 (2012: $2,181). There is no unused facility in relation to the commercial bill line. Interest Rate Risk The Group’s exposure to interest rates and the effective weighted average interest rate by maturity period is set out in note 22. NOTE 17: PROVISIONS CURRENT Employee benefits NON-CURRENT Employee benefits NOTE 18: OTHER LIABILITIES CURRENT unearned income NOTE 19: ISSUED CAPITAL (a) Issued and paid-up capital Ordinary shares – fully paid 2013 $ 2012 $ 1,081,086 888,808 66,327 18,239 2013 $ 37,447 37,447 2012 $ 18,188 18,188 2013 SHARES 2012 SHARES 415,879,455 345,384,619 65 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 19: ISSUED CAPITAL CONT. Movements in ordinary shares of the Company during the past two years were as follows: DATE DETAILS 30 June 2011 30 June 2012 30 June 2013 Closing balance Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Closing balance Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – ESOp option exercise Share issue – acquisition Share issue – entitlements issue Share issue – entitlements issue costs Shares to be issued – acquisition Shares to be issued – acquisition NUMBER OF SHARES 344,731,779 340,000 90,000 35,000 54,000 30,000 5,150 15,000 12,000 5,000 66,690 345,384,619 340,000 20,526 110,000 122,500 200,000 150,000 15,000 19,112,575 45,634,962 - 1,197,322 3,591,951 415,879,455 ISSUE PRICE $0.13 $0.215 $0.22 $0.24 $0.28 $0.29 $0.2976 $0.36 $0.38 $0.5848 $0.13 $0.22 $0.24 $0.29 $0.30 $0.34 $0.36 $0.32 $0.36 - $0.32 $0.32 $ 87,690,990 44,200 19,350 7,700 12,960 8,400 1,494 4,464 4,320 1,900 39,000 87,834,778 44,200 4,516 26,400 35,525 60,000 51,000 5,400 6,116,024 16,428,586 (826,424) 383,143 1,149,424 111,312,572 Changes to the then Corporations Law abolished the authorised capital and par value concept in relation to share capital from 1 July 1998. Therefore, the Company does not have a limited amount of authorised capital and issued shares do not have a par value. (b) Ordinary Shares Ordinary shares entitle the holder to participate in dividends and the proceeds on winding up of the Company in proportion to the number of and amounts paid on the shares held. On a show of hands every holder of ordinary shares present at a meeting in person or by proxy, is entitled to one vote and upon a poll each share is entitled to one vote. (c) Share Options When exercised, each option is convertible into one ordinary share. The exercise price is based on the weighted average price at which the company’s shares traded on the ASX during the seven trading days immediately before the options are issued. (i) The Bionomics ESOP The terms and conditions of the Bionomics ESOp are summarised in note 1(p) (iv). The following options listed are outstanding at reporting date. NOTE 19: ISSUED CAPITAL CONT. GRANT DATE Jan-04 Mar-04 Sept-04 Jan-05 Jan-06 May-06 nov-06 Oct-07 Jan-08 Jul-08 Sep-08 nov-08 Jan-09 Mar-09 Jun-09 nov-09 EXPIRY DATE Jan-14 Mar-14 Mar-14 nov-13 feb-14 feb-15 Jan-14 Jan-15 Jan-16 Jul-13 Jul-14 Jul-15 Jul-16 nov-13 nov-14 nov-15 nov-16 Oct-13 Oct-14 Oct-15 Oct-16 Oct-17 Jan-14 Jan-15 Jan-16 Jan-17 Jan-18 Jul-13 Jul-14 Jul-15 Jul-16 Jul-17 Jul-18 Sep-14 Sep-15 Sep-16 Sep-17 Sep-18 nov-13 nov-14 nov-15 nov-16 nov-17 nov-13 Aug-14 Aug-15 Aug-16 nov-14 nov-15 nov-16 nov-17 nov-18 Jan-14 Mar-15 Mar-16 Mar-17 Mar-18 Mar-19 Jun-14 Jun-15 Jun-16 Jun-17 Jun-18 Jun-19 nov-15 nov-16 nov-17 nov-18 nov-19 EXERCISE PRICE $0.30 $0.37 $0.38 $0.24 $0.30 $0.30 $0.24 $0.24 $0.24 $0.22 $0.22 $0.22 $0.22 $0.30 $0.30 $0.30 $0.30 $0.29 $0.29 $0.29 $0.29 $0.29 $0.38 $0.38 $0.38 $0.38 $0.38 $0.36 $0.36 $0.36 $0.36 $0.36 $0.36 $0.34 $0.34 $0.34 $0.34 $0.34 $0.30 $0.30 $0.30 $0.30 $0.30 $0.37 $0.37 $0.37 $0.37 $0.28 $0.28 $0.28 $0.28 $0.28 $0.30 $0.29 $0.29 $0.29 $0.29 $0.29 $0.25 $0.25 $0.25 $0.25 $0.25 $0.25 $0.30 $0.30 $0.30 $0.30 $0.30 66 FAIR VALUE AT GRANT DATE $0.21 $0.16 $0.16 $0.14 $0.13 $0.13 $0.14 $0.15 $0.15 $0.13 $0.13 $0.13 $0.14 $0.12 $0.13 $0.13 $0.13 $0.21 $0.23 $0.23 $0.24 $0.25 $0.19 $0.20 $0.21 $0.22 $0.23 $0.16 $0.17 $0.18 $0.19 $0.19 $0.20 $0.17 $0.18 $0.19 $0.19 $0.20 $0.09 $0.10 $0.10 $0.11 $0.12 $0.07 $0.08 $0.09 $0.10 $0.06 $0.05 $0.06 $0.06 $0.07 $0.05 $0.06 $0.07 $0.07 $0.08 $0.08 $0.12 $0.13 $0.13 $0.14 $0.14 $0.15 $0.11 $0.12 $0.13 $0.14 $0.14 NUMBER 5,000 7,000 5,000 200,000 200,000 200,000 45,000 45,000 45,000 65,000 95,000 99,474 100,000 100,000 100,000 100,000 100,000 5,000 5,000 5,000 5,000 5,000 4,000 4,000 4,000 4,000 4,000 90,000 18,000 18,000 18,000 18,000 18,000 4,000 4,000 4,000 4,000 4,000 100,000 100,000 100,000 100,000 100,000 95,000 340,000 330,000 330,000 10,000 10,000 10,000 20,000 20,000 165,000 12,120 12,120 12,120 12,120 12,120 115,200 54,000 54,000 54,000 54,000 54,000 100,000 100,000 100,000 100,000 100,000 67 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 19: ISSUED CAPITAL CONT. GRANT DATE Jul-10 nov-10 nov-11 Dec-11 feb-12 Mar-12 Jun-12 Aug-12 Dec-12 Dec-12 Mar-13 May-13 Jun-13 EXPIRY DATE July-15 Jul-16 Jul-17 Jul-18 Jul-19 Jul-20 nov-15 nov-16 nov-17 nov-18 nov-19 nov-16 nov-16 Aug-17 Dec-17 Dec-18 Dec-19 Dec-20 Dec-21 feb-18 feb-19 feb-20 feb-21 feb-22 Mar-18 Mar-19 Mar-20 Mar-21 Mar-22 Jun-18 Jun-19 Jun-20 Jun-21 Jun-22 Aug-17 Aug-18 Aug-19 Aug-20 Aug-21 Aug-22 Dec-17 Dec-18 Dec-19 Dec-20 Dec-21 Dec-22 Dec-18 Dec-19 Dec-20 Dec-21 Dec-22 Mar-19 Mar-20 Mar-21 Mar-22 Mar-23 May-19 May-20 May-21 May-22 May-23 Jun-19 Jun-20 Jun-21 Jun-22 Jun-23 EXERCISE PRICE $0.32 $0.32 $0.32 $0.32 $0.32 $0.32 $0.31 $0.31 $0.31 $0.31 $0.31 $0.61 $0.61 $0.92 $0.52 $0.52 $0.52 $0.52 $0.52 $0.52 $0.52 $0.52 $0.52 $0.52 $0.51 $0.51 $0.51 $0.51 $0.51 $0.34 $0.34 $0.34 $0.34 $0.34 $0.29 $0.25 $0.25 $0.25 $0.25 $0.25 $0.29 $0.32 $0.32 $0.32 $0.32 $0.32 $0.32 $0.32 $0.32 $0.32 $0.32 $0.42 $0.42 $0.42 $0.42 $0.42 $0.37 $0.37 $0.37 $0.37 $0.37 $0.39 $0.39 $0.39 $0.39 $0.39 NUMBER 90,000 10,000 10,000 10,000 10,000 10,000 100,000 100,000 100,000 100,000 100,000 95,000 500,000 1,000,000 100,000 100,000 100,000 100,000 100,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 13,000 13,000 13,000 13,000 13,000 200,000 4,000 4,000 4,000 4,000 4,000 65,000 200,000 200,000 200,000 200,000 200,000 5,000 5,000 5,000 5,000 5,000 50,000 50,000 50,000 50,000 50,000 114,000 114,000 114,000 114,000 114,000 150,000 150,000 150,000 150,000 150,000 10,262,274 FAIR VALUE AT GRANT DATE $0.12 $0.11 $0.12 $0.13 $0.13 $0.14 $0.09 $0.10 $0.11 $0.12 $0.12 $0.15 $0.15 $0.03 $0.23 $0.25 $0.26 $0.27 $0.28 $0.20 $0.21 $0.22 $0.23 $0.24 $0.20 $0.21 $0.22 $0.23 $0.24 $0.11 $0.12 $0.13 $0.13 $0.14 $0.09 $0.13 $0.14 $0.15 $0.15 $0.16 $0.11 $0.12 $0.13 $0.14 $0.14 $0.15 $0.15 $0.16 $0.16 $0.17 $0.18 $0.14 $0.15 $0.16 $0.17 $0.18 $0.15 $0.16 $0.17 $0.18 $0.19 $0.14 $0.15 $0.16 $0.17 $0.18 68 NOTE 19: ISSUED CAPITAL CONT. Reconciliation of ESOP: 2013 2012 NUMBER OF OPTIONS WEIGHTED AVERAGE EXERCISE PRICE NUMBER OF OPTIONS WEIGHTED AVERAGE EXERCISE PRICE Opening balance at beginning of financial year Granted during the financial year forfeited during the financial year Exercised during the financial year Expired during the financial year Closing balance at 30 June 8,865,900 2,880,000 (50,000) (958,026) (475,600) 10,262,274 $0.40 $0.35 $0.34 $0.24 $0.30 $0.41 7,766,715 2,210,000 (8,000) (586,150) (516,665) 8,865,900 $0.31 $0.72 $0.36 $0.18 $0.52 $0.40 ESOP options exercised during the financial year: SERIES 1-Sep-04 04-Oct-07 04-Oct-07 04-Oct-07 04-Oct-07 13-Jan-06 26-Sep-08 21-Jan-05 18-Oct-04 01-May-06 01-Jul-08 01-May-06 01-Jul-08 01-May-06 01-Jul-08 01-May-06 01-May-06 Unlisted options vested and exercisable at the reporting date (iii) Weighted averages NUMBER EXERCISED 100,000 22,000 5,150 90,000 5,350 10,000 150,000 200,000 340,000 5,000 5,000 5,000 5,000 5,000 5,000 5,000 526 958,026 EXERCISE DATE SHARE PRICE AT EXERCISE DATE 26-Sep-12 27-Sep-12 28-Sep-12 02-Oct-12 02-Oct-12 19-Dec-12 25-Jan-13 14-feb-13 14-Jun-13 24-Jun-13 24-Jun-13 25-Jun-13 25-Jun-13 25-Jun-13 25-Jun-13 25-Jun-13 25-Jun-13 $0.390 $0.385 $0.375 $0.360 $0.360 $0.350 $0.410 $0.430 $0.350 $0.335 $0.335 $0.315 $0.315 $0.315 $0.315 $0.315 $0.315 2013 NUMBER 6,617,154 2012 NUMBER 7,185,660 The weighted average remaining contractual life of any unlisted share options outstanding at the end of the year is 4.27 years (2012: 3.6 years). The assessed fair value at grant date of options granted during the year ended 30 June 2013 is outlined in the Remuneration Report on page 30. The share price at grant date of these options ranged between $0.29 and $0.39 (2012: $0.30 and $0.58). The expected average price volatility of the company shares was 57% (2012: 60%). Expected dividend yield was 0% (2012: 0%) and the average risk free interest rate used was 3.19% (2012: 3.51%). Additional details on options granted in prior years are available in those year’s Annual Reports. 69 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 20: RESERVES (a) Foreign Currency Translation Reserve Exchange differences arising on translation of the foreign controlled entity are taken to the foreign currency translation reserve, as described in note 1(b). The reserve is recognised in profit or loss when the investment is disposed of. Opening balance Exchange differences on translation of foreign operations Closing balance 2013 $ (645,886) 1,894,514 1,248,628 2012 $ (552,274) (93,612) (645,886) (b) Share-based Payments Reserve The share-based payments reserve is used to recognise the fair value of options issued to the extent that they have vested. Opening balance Option expense Closing balance Total reserves NOTE 21: ACCUMULATED LOSSES Balance at the beginning of the year net loss for the year Balance at the end of the year NOTE 22: FINANCIAL INSTRUMENTS (a) Capital Risk Management 2013 $ 1,533,134 136,908 2012 $ 1,247,135 285,999 1,670,042 1,533,134 2,918,670 887,248 2013 $ 2012 $ (62,822,909) (59,686,671) (10,001,350) (3,136,238) (72,824,259) (62,822,909) The Group manages its capital to ensure that entities in the Group will be able to continue as going concerns whilst maximising the return to stakeholders through the optimisation of the debt and equity balance. The Group’s overall strategy remains unchanged from 2012. The capital structure of the Group consists of debt, which includes borrowings (note 16), cash and cash equivalents (note 7) and equity attributable to equity holders of the parent, comprising issued capital, reserves and retained earnings (disclosed in notes 19, 20 and 21 respectively). The Group has global operations, primarily conducted through subsidiary companies established in the markets in which the Group trades. none of the Group’s entities is subject to externally imposed capital requirements. The Group’s policy is to fund the research and development activities and operations through the issue of equity and the commercialisation of intellectual property assets. Minor borrowings for operational assets are utilised, as appropriate. NOTE 22: FINANCIAL INSTRUMENTS CONT. CATEGORIES OF FINANCIAL INSTRUMENTS Financial assets Loans and receivables Cash and cash equivalents fair value through profit or loss (fvTpL) held for trading Financial liabilities Amortised cost Reconciliation to total assets financial assets (as above) non-financial assets Reconciliation to total liabilities financial liabilities (as above) non-financial liabilities 70 2013 $ 2012 $ 742,371 411,417 22,452,089 17,336,609 - 36,232 23,194,460 17,784,258 5,053,760 5,053,760 4,081,133 4,081,133 23,194,460 17,784,258 30,416,632 13,317,930 53,611,092 31,102,188 5,053,760 7,150,349 4,081,133 1,121,938 12,204,109 5,203,071 (b) Financial Risk Management Objectives The Board, through the Audit and Risk Management (ARM) Committee, is responsible for ensuring there are adequate policies in relation to risk management, compliance and internal control systems. in summary, Company policies are designed to ensure significant strategic, operational, legal, reputational and financial risks are identified, assessed, and effectively monitored and managed in a manner sufficient for a company of Bionomics’ size and stage of development to enable achievement of the Company’s business strategy and objectives. The Company’s risk management policies are managed by the key management personnel and are reviewed by the ARM Committee according to a timetable of assessment and review proposed by that Committee and approved by the Board. (c) Market Risk The Group’s activities do not expose it to significant financial risks of changes in foreign currency exchange rates or interest rates. The Group uses derivative financial instruments to manage its exposure to foreign currency risk including: 3 forward foreign exchange contracts and currency swaps to hedge the exchange rate risk arising on the payments for clinical trials in non-Australian dollar denominated contracts. The Group measures market risk exposures using sensitivity analysis. There has been no material change to the Group’s exposure to market risks or the manner in which these risks are managed and measured. unless approved by the Chief Executive Officer and Managing Director and ARM Committee, interest rate derivatives are not entered into. (d) Foreign Currency Risk Management The Group undertakes certain transactions denominated in foreign currencies; consequently exposures to exchange rate fluctuations arise. Exchange rate exposures are managed in accordance with established policies. The carrying amounts of the Group’s foreign currency denominated monetary assets and liabilities at the end of the reporting date are as follows: 71 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 22: FINANCIAL INSTRUMENTS CONT. EuR uSD GBp LIABILITIES ASSETS 2013 $ 2012 $ 955,052 1,052,732 1,069,479 43,067 681,961 - 2013 $ 2,107,512 358,542 - 2012 $ 1,642,171 389,194 - Foreign Currency Sensitivity Analysis The Group is mainly exposed to Great Britain pounds, Euros and uS dollars. The following table details the Group’s sensitivity to a 10% increase and decrease in the Australian dollar against the relevant foreign currencies. 10% is the sensitivity rate used when reporting foreign currency risk internally to key management personnel and represents management’s assessment of the reasonably possible change in foreign currency rates. The sensitivity analysis includes only outstanding foreign currency denominated monetary items and adjusts their translation at the year- end for a 10% change in foreign currency rates. A positive number below indicates an increase in profit or equity where the Australian dollar strengthens 10% against the relevant currency. for a 10% weakening of the Australian dollar against the relevant currency, there would be a comparable impact on the profit or equity with the balances being the opposite. EUR IMPACT USD IMPACT GBP IMPACT 2013 $ 10,828 2012 $ - (i) 2013 $ 2012 $ 59,717 26,615 (ii) (115,597) (53,585) (iii) 4,914 (v) - 2013 $ 3,915 - 2012 $ - (iv) - profit or loss Equity this is mainly attributable to the exposure outstanding on Euro payables in the Group at the end of the reporting period. (i) (ii) this is mainly attributable to the exposure to outstanding uSD net assets at the end of the reporting period. (iii) this is as a result of the changes in fair value of the net investment in a subsidiary denominated in Euros, reflected in the foreign currency translation reserve. (iv) this is mainly attributable to the exposure outstanding on GBp payables in the Group at the end of the reporting period. (v) this is as a result of the changes in fair value of the net investment in a subsidiary denominated in uSD, reflected in the foreign currency translation reserve. The Group’s sensitivity to foreign currency has increased during the current year mainly due to the mix of net assets held in non-Australian dollar denominated currencies. The sensitivity analysis may not represent the quantum of foreign exchange risk because the exposure at the end of the reporting period does not reflect the exposure during the year. Requirements change during the financial year depending on research and development activities being undertaken and contract research service financial performance. Forward Foreign Exchange Contracts it is the policy of the Group to enter into forward foreign currency contracts to cover specific foreign currency payments and receipts when there is a legal commitment to pay or receive foreign currency or the Chief Executive Officer and Managing Director has a high degree of confidence (>90%) that a foreign currency exposure will arise. under the Group’s Treasury policy, the Chief financial Officer (CfO) will manage the foreign exchange transaction risk adopting the following guidelines: 3 generally hedge foreign exchange exposure identified above by entering into a forward currency contract. 3 the duration of any forward currency contract(s) will approximate the period in which the net currency exposure arise. 3 recognising the uncertainty that exists in the projecting forward foreign currency flows, a maximum net foreign currency exposure position may be held at any point in time. 72 NOTE 22: FINANCIAL INSTRUMENTS CONT. Due to the long-term nature of the net investment in the Euro denominated wholly owned subsidiary, the investment will not be hedged into Australian dollars, with the result that the Australia dollar value of the investment will fluctuate with the market rate through the foreign currency translation reserve. The following table details the forward foreign currency (fC) contracts outstanding at the end of the reporting period: AVERAGE RATE FOREIGN CURRENCY CONTRACT VALUE FAIR VALUE EURO (Sell) 3 – 6 months US (Buy) Less than 3 months 3 – 6 months 2013 2012 2013 FC - - - - 1.0457 0.9568 - - - 2012 FC - 2,000,000 250,000 2013 $ - - - 2012 $ - 1,912,905 261,288 2013 $ 2012 $ - - - - - 50,158 (13,926) 36,232 The table above provides an example of summary quantitative data about exposure to foreign exchange risks at the end of the reporting period that an entity may provide internally to key management personnel. (e) Interest Rate Risk Management The Group is exposed to interest rate risk as entities in the Group borrow funds at both fixed and variable interest rates and lend funds at variable rates. The Group does not use interest rate swap contracts or forward interest rate contracts. Interest Rate Sensitivity Analysis The sensitivity analysis below has been determined based on the exposure to interest rates at the end of the reporting period and the stipulated change taking place at the beginning of the financial year and held constant throughout the reporting period. if interest rates had been 50 basis points higher / (lower) and all other variables were held constant, the Group’s: 3 loss for the year ended 30 June 2013 would increase / (decrease) by $93,829 (2012: increase / (decrease) by $73,443). This is mainly attributable to the Group’s exposure to interest rates on its variable rate deposits. The Group’s sensitivity to interest rates has increased during the current year mainly due to the increase in cash and cash equivalent balances and reduction in debt. (f) Credit Risk Management Credit risk refers to the risk that a counterparty will default on its contractual obligations resulting in financial loss to the Group. The Group has adopted a policy of only dealing with creditworthy counterparties and obtaining sufficient collateral, where appropriate, as a means of mitigating the risk of financial loss from defaults. The Group does not have any significant credit risk exposure to any single counterparty or any group of counterparties having similar characteristics. The credit risk on liquid funds is limited because the counterparties are banks with high credit ratings assigned by international credit rating agencies. The carrying amount of financial assets recorded in the financial statements, net of any allowances for losses, represents the Group’s maximum exposure to credit risk. (g) Liquidity Risk Management ultimate responsibility for liquidity risk management rests with the Board, who have built an appropriate liquidity risk management framework for management of the Group’s short, medium and long term funding. The Group manages liquidity risk by continuously monitoring forecast and actual cash flows and matching maturity profiles of financial assets and liabilities. included in note 16 is a listing of additional undrawn facilities that the group has at its disposal to further reduce liquidity risk. 73 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 22: FINANCIAL INSTRUMENTS CONT. (h) Liquidity and Interest Rate Risk The following tables detail the Group’s remaining contractual maturity for its financial liabilities. The tables have been drawn up based on the undiscounted cash flows of financial liabilities based on the earliest date on which the Group can be required to pay. The tables include both interest and principal cash flows. INTEREST RATE MATURITY WEIGHTED AVERAGE EFFECTIVE INTEREST RATE % LESS THAN 1 MONTH $ 1–3 MONTHS $ 3–12 MONTHS $ 1–5 YEARS $ 5+ YEARS $ TOTAL $ 2013 non-interest bearing finance lease liability fixed interest rate instruments TOTAL 2012 non-interest bearing forward exchange contracts (payable) forward exchange contracts (receivable) finance lease liability fixed interest rate instruments TOTAL 3,973,225 - - - 7.11 12,571 25,142 113,139 347,591 3.81 550,000 - 7,002 4,535,796 25,142 120,141 80,592 428,183 2,681,517 - - 487,805 1,425,100 261,288 (493,754) (1,469,309) (247,362) - - - 7.14 13,387 38,388 119,670 498,443 4.31 550,000 - - - 3,238,955 (5,821) 133,596 498,443 - - - - - - - - - - 3,973,225 498,443 637,594 5,109,262 2,681,517 2,174,193 (2,210,425) 669,888 550,000 3,865,173 NOTE 23: KEY MANAGEMENT PERSONNEL DISCLOSURES (a) Directors The following persons were directors of Bionomics during the financial year and prior year unless otherwise stated: Non-Executive Chairman Mr Graeme kaufman (appointed 18 September 2012) Executive Director Dr Deborah Rathjen, Chief Executive Officer and Managing Director Non-Executive Directors Mr Trevor Tappenden Dr Errol De Souza Dr Jonathan Lim (appointed 14 September 2012) Mr Christopher fullerton (retired 31 December 2012) (b) Other Key Management Personnel The following persons also had authority and responsibility for planning, directing and controlling the activities of the Group directly or indirectly during the financial year: NAME Dr José iglesias Ms Melanie Young POSITION Chief Medical Officer Chief financial Officer and Company Secretary 74 NOTE 23: KEY MANAGEMENT PERSONNEL DISCLOSURES CONT. (c) Key Management Personnel Compensation The aggregate compensation made to key management personnel of the Group is set out below: Short-term employee benefits post-employment benefits Share-based payments Total key management personnel compensation NOTE 24: COMMITMENTS FOR EXPENDITURE (a) Finance Leases 2013 $ 2012 $ 1,245,426 1,433,265 49,778 96,025 76,115 215,664 1,391,229 1,725,044 The Group leases scientific equipment under finance leases. The average lease term is four years (2012: four years). under the terms of the lease, the Group retains ownership at the completion of the agreed term. interest rates underlying all obligations under finance leases are fixed at the respective contract dates ranging from 4.5% to 7.29% (2012: 7.1% to 8.9%) per annum. MINIMUM LEASE PAYMENTS PRESENT VALUE OF LEASE PAYMENTS FINANCE LEASE LIABILITIES Within one year Later than one year but not greater than five future finance charges Present value of minimum lease payments 2013 $ 150,852 435,128 585,980 (55,445) 530,535 2012 $ 171,445 498,443 669,888 (91,163) 578,725 Represented in the financial statements (note 16) by: Current borrowings non-current borrowings (b) Operating Leases 2013 $ 122,885 407,650 530,535 - 2012 $ 134,783 443,942 578,725 - 530,535 578,725 2013 $ 130,376 400,159 530,535 2012 $ 134,783 443,942 578,725 Operating leases relate to business premises with lease terms of between two and ten years. The building premise leases have options of +2 and +5+5 year terms respectively. PAYMENTS RECOGNISED AS AN EXPENSE Minimum lease payments NON-CANCELLABLE OPERATING LEASE COMMITMENTS Within one year Later than one year but not greater than five Later than five years Minimum lease payments 2013 $ 2012 $ 850,955 894,252 1,003,196 4,095,463 2,575,996 7,674,655 885,505 3,745,267 3,531,191 8,161,963 75 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 24: COMMITMENTS FOR EXPENDITURE CONT. The non-cancellable lease commitments include the rent payable under the sale and leaseback of the headquarters. The sale occurred on 29 April 2011, with settlement occurring on 13 July 2011. The total lease commitments are expected to be $6,392,784 (2012: $7,229,077), and are considered market related. (b) Rental Agreements The Group sub-lets areas of its facility under agreements that are renewed annually. Rent received from these agreements is treated according to the accounting policy outlined in note 1(c). FUTURE RENTAL INCOME RECEIVABLE Within one year Later than one year but not greater than five 2013 $ 155,369 - 155,369 2012 $ 173,219 157,870 331,089 NOTE 25: EVENTS OCCURRING AFTER REPORTING DATE no matters or circumstances have arisen since the end of the financial year which significantly affect or may significantly affect the results of the operations of the Group, except as noted below. On 31 July 2013 Bionomics announced an agreement with Merck, known as MSD outside the united States and Canada, to discover and develop novel small molecule candidates for the treatment of chronic pain. Merck will have the option to exclusively license a compound from Bionomics for development and commercialisation. in return, Bionomics may receive option exercise fees and development and regulatory milestone payments of up to uS$172 million. Bionomics may also be eligible for undisclosed royalties on net sales of products from the collaboration. NOTE 26: REMUNERATION OF AUDITORS During the financial year the following services were paid and payable to the external auditor: AUDITOR OF THE PARENT ENTITY Audit or review of the financial report Tax compliance including preparation of the income tax return Other non-audit services The auditor of Bionomics Limited is Deloitte Touche Tohmatsu. 2013 $ 158,566 6,300 12,798 2012 $ 130,535 16,900 12,805 177,664 160,240 it is the Group’s practice to employ Deloitte Touche Tohmatsu on assignments additional to their statutory audit duties where their expertise and experience with the Group are important. NOTE 27: CASH FLOW INFORMATION Reconciliation of operating loss after income tax to net cash outflow from operating activities Loss for the year after income tax items in loss - Depreciation and amortisation - Share-based payments - income tax expense/(benefit) - net unrealised foreign exchange differences 2013 $ 2012 $ (10,001,350) (3,136,238) 1,245,815 136,908 38,175 869,526 696,717 324,999 (192,658) (145,655) 76 2013 $ (7,016,607) 2012 $ - (1,037,151) (1,123,099) 204,317 3,907,756 (56,616) 36,758 240,366 19,259 (1,495,733) - (111,830) (96,413) 101,120 (33,815) 1,362,138 1,198,463 (10,050,706) (4,014,142) 2013 $ - - 2013 CENTS (2.7) (2.7) 2012 $ 648,796 648,796 2012 CENTS (0.9) (0.9) NOTE 27: CASH FLOW INFORMATION CONT. - Accrued grant income - interest received / receivable Changes in operating assets and liabilities - Decrease/(increase) in debtors and other assets - Decrease/(increase) in accrued income - increase in other operating assets - Decrease/(increase) in inventory - Movement in provisions - increase/(Decrease) in unearned income - increase in creditors and accruals Net cash outflows from operating activities NOTE 28: NON-CASH FINANCING ACTIVITIES Acquisition of equipment under a finance lease NOTE 29: LOSS PER SHARE Basic loss per share Diluted loss per share The basic and diluted loss per share amounts have been calculated using the ‘Loss after income tax’ figure in the consolidated statement of comprehensive income. LOSS PER SHARE (BASIC AND DILUTED): Loss after tax for the year 2013 $ 2012 $ (10,001,350) (3,136,238) 2013 NUMBER 2012 NUMBER Weighted average number of shares - Basic Weighted average number of ordinary shares used in calculating basic loss per share: 374,438,730 344,928,141 Weighted average number of shares – Diluted Weighted average number of ordinary shares used in calculating basic loss per share: 374,438,730 344,928,141 Shares deemed to be issued for no consideration in respect of: - Employee options Weighted average number of ordinary shares used in the calculation of diluted earnings per share 468,564 2,060,462 374,907,294 346,988,603 The following potential ordinary shares are anti-dilutive and are therefore excluded from the weighted average number of ordinary shares for the purposes of diluted earnings per share. Employee options 2013 NUMBER 5,107,000 2012 NUMBER 2,155,000 77 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 30: RELATED PARTY TRANSACTIONS (a) Parent Entity The immediate parent and ultimate controlling party of the Group is Bionomics Limited. interests in subsidiaries are set out in note 12. (b) Key Management Personnel Disclosures relating to compensation of key management personnel are set out in note 23 and the Directors’ Report. (c) Other Transactions with Related Parties Transactions between the Group and its related parties During the financial year ended 30 June 2013, the following transactions occurred between the Group and its other related parties: 3 research and development services between the parent and subsidiary entities totalled $4,246,642 (2012: $917,543). 3 corporate support fees were charged between the Group’s entities of $1,091,000 (2012: $281,356) for management and accounting support. The following balances arising from transactions between the Group and its other related parties are outstanding at reporting date: 3 loan receivables totalling $1,124,647 (2012: $755,710) are payable by the subsidiaries to the parent entity. All amounts advanced to or payable to related parties are unsecured and are subordinate to other liabilities. interest has been waived since 2010. The amounts outstanding will be settled in cash. no guarantees have been given or received. no expense has been recognised in the period for bad or doubtful debts in respect of the amounts owed by related parties. Transactions between the Group and its associates were eliminated in the preparation of the consolidated financial statements of the Group to the extent of the Group’s share in profits and losses of the associate resulting from these transactions. (d) Loans To and From Related Parties no loans to or from related parties have occurred in the current or previous financial year. (e) Key Management Personnel Equity Holdings (i) Options provided as remuneration and shares issued on the exercise of such options are outlined below, and the terms and conditions of the options can be found in note 1(p)(iv). (ii) The number of unlisted options over ordinary shares in the company held by each director of the company and other key management personnel (including related parties) of the Group are set out below. All options that are vested are exercisable. 2013 OPTIONS NAME Mr Graeme kaufman Dr Deborah Rathjen Mr Trevor Tappenden1 Dr Errol De Souza Dr Jonathan Lim BALANCE AT THE START OF THE YEAR - 3,120,000 500,000 500,000 - - - 500,000 Mr Christopher fullerton3 1,000,000 Ms Melanie Young Dr José iglesias 500,000 - - 75,000 500,000 GRANTED DURING THE YEAR AS COMPEN- SATION EXERCISED DURING THE YEAR NET OTHER CHANGES DURING THE YEAR BALANCE AT YEAR END VESTED AND EXERCISABLE AT YEAR END 500,000 65,000 - (430,000) - - 500,000 - 2,755,000 2,755,000 - - - - - - (100,000) - - (1,000,000) - - 400,000 500,000 500,000 - 575,000 500,000 400,000 500,000 - - 175,000 - 5,620,000 1,640,000 (430,000) (1,100,000) 5,730,000 3,830,000 78 NOTE 30: RELATED PARTY TRANSACTIONS CONT. 2012 OPTIONS NAME Mr Christopher fullerton Dr Deborah Rathjen2 Mr Trevor Tappenden1 Dr Errol De Souza Ms Melanie Young BALANCE AT THE START OF THE YEAR 1,000,000 1,965,000 500,000 500,000 GRANTED DURING THE YEAR AS COMPEN- SATION EXERCISED DURING THE YEAR NET OTHER CHANGES DURING THE YEAR BALANCE AT YEAR END VESTED AND EXERCISABLE AT YEAR END - - - 1,595,000 (340,000) (100,000) - - - 500,000 - - - - - - 1,000,000 3,120,000 500,000 500,000 500,000 400,000 3,120,000 500,000 400,000 - 3,965,000 2,095,000 (340,000) (100,000) 5,620,000 4,420,000 1held by kelso investments Australia pty Ltd 2includes 1,000,000 options vested August 2012 to Dr Deborah Rathjen for services performed in 2011/2012 3Mr Christopher fullerton retired 31 December 2012 and is no longer disclosed (iii) The number of shares in the company held by each director of the Company and other key management personnel (including personally related parties) of the Group are set out below: 2013 SHARES NAME Mr Graeme kaufman Dr Deborah Rathjen Mr Trevor Tappenden2 Dr Errol De Souza Dr Jonathan Lim Mr Christopher fullerton1, 3 Ms Melanie Young Dr José iglesias 2012 SHARES NAME Mr Christopher fullerton1 Dr Deborah Rathjen Mr Trevor Tappenden2 Dr Errol De Souza Ms Melanie Young BALANCE AT THE START OF THE YEAR GRANTED DURING THE YEAR AS COMPEN- SATION RECEIVED DURING THE YEAR UPON EXERCISE OF OPTIONS NET OTHER CHANGES DURING THE YEAR - 1,533,689 220,000 116,698 - 4,200,000 18,710 - 6,089,097 - - - - - - - - - BALANCE AT YEAR END 178,750 1,965,401 247,500 116,698 178,750 1,712 27,500 - 4,073,463 4,073,463 (4,200,000) 20,339 - - 39,049 - - 430,000 - - - - - - 430,000 101,764 6,620,861 BALANCE AT THE START OF THE YEAR GRANTED DURING THE YEAR AS COMPEN- SATION RECEIVED DURING THE YEAR UPON EXERCISE OF OPTIONS NET OTHER CHANGES DURING THE YEAR 4,825,020 1,343,689 245,899 116,698 - 6,531,306 - - - - 1,710 1,710 - 340,000 - - - (625,020) (150,000) (25,899) - 17,000 BALANCE AT YEAR END 4,200,000 1,533,689 220,000 116,698 18,710 340,000 (783,919) 6,089,097 1held by Mandalay Capital pty Ltd 2held by kelso investments Australia pty Ltd 3Mr Christopher fullerton retired 31 December 2012 and is no longer disclosed 79 NOTES TO THE FINANCIAl STATEMENTS FOR THE FINANCIAl YEAR ENDED 30 JuNE 2013 NOTE 30: RELATED PARTY TRANSACTIONS CONT. (f) Loans to Directors and Other Key Management Personnel There were no loans to any directors of the Company or other key management personnel of the Group during the financial year ended 30 June 2013. (g) Other Transactions with Directors and Other Key Management Personnel There were no other transactions with directors of the Company or other key management personnel of the Group during the financial year. NOTE 31: PARENT ENTITY INFORMATION The accounting policies of the parent entity, which have been applied in determining the financial information shown below, are the same as those applied in the consolidated financial statements. Refer to note 1 for a summary of the significant accounting polices relating to the Group. FINANCIAL POSITION ASSETS Current assets non-current assets Total assets LIABILITIES Current liabilities non-current liabilities Total liabilities Net Assets EQUITY issued capital Accumulated losses Share-based payments reserve Total equity FINANCIAL PERFORMANCE Loss for the year Other comprehensive income Total comprehensive income YEAR ENDED 30 JUNE 2013 $ YEAR ENDED 30 JUNE 2012 $ 31,203,186 21,566,896 20,750,731 9,463,051 51,953,917 31,029,947 5,287,458 5,096,108 3,837,756 462,181 10,383,566 4,299,937 41,570,351 26,730,010 111,312,572 87,834,778 (71,412,263) (62,637,902) 1,670,042 1,533,134 41,570,351 26,730,010 YEAR ENDED 30 JUNE 2013 YEAR ENDED 30 JUNE 2012 (8,774,362) (2,777,626) - - (8,774,362) (2,777,626) (a) Property, Plant and Equipment Commitments There are no contractual commitments for the acquisition of property, plant or equipment as at 30 June 2013 (2012: nil). (b) Contingent Liabilities and Guarantees There are no contingent liabilities or guarantees as at 30 June 2013 (2012: nil). NOTE 32: BUSINESS COMBINATIONS – ACQUISITION OF ECLIPSE THERAPEUTICS, INC On 17 September 2012 the Company announced the acquisition of Eclipse Therapeutics, inc into the wholly owned subsidiary Bionomics inc with effect from 14 September 2012. Bionomics inc is engaged in Cancer Stem Cell research and development activities and is complementary to the Group’s existing oncology research and development program. 80 NOTE 32: BUSINESS COMBINATIONS - ACQUISITION OF ECLIPSE THERAPEUTICS, INC CONT. CONSIDERATION TRANSFERRED Shares issued Shares issuable (estimated maximum) Cash Total consideration Contingent consideration (i) NUMBER 19,112,575 4,778,143 - $ 6,116,024 1,532,567 14,246 23,890,718 7,662,837 4,681,749 12,344,586 (i) The contingent consideration is the estimated fair value of the potential cash earn-outs to Eclipse security holders based on achieving late stage development success or partnering outcomes based on Eclipse assets. The contingent consideration of $4,681,749 at the acquisition date has been revalued at 30 June 2013 due to the movement in the uS / Australian dollar exchange rate to $5,348,695. ASSETS ACQUIRED AND LIABILITIES ASSUMED AT THE DATE OF ACQUISITION CURRENT ASSETS Cash and cash equivalents Other current assets NON-CURRENT ASSETS plant and equipment intellectual property CURRENT LIABILITIES Trade and other payables $ 270,525 7,256 109,853 12,703,228 (746,276) 12,344,586 in accordance with the Accounting Standard AASB 3 ‘Business Combinations’, the Company is able to provisionally determine the initial accounting for the acquisition. At the end of the year, the intangible assets have been provisionally determined based on the directors’ best estimate of the likely fair value at $12,703,228. The calculation of the consideration transferred and intangible assets, including but not limited to intellectual property, goodwill and deferred tax assets may be amended when further information to support these values is obtained. included in the loss for the year ended 30 June 2013 is $1,927,691 attributable to this acquisition. had the acquisition been effected at 1 July 2012, the loss from continuing operations for the year would have increased by an additional $280 thousand, the ‘pro-forma’ loss. in determining the ‘pro-forma’ loss of the Group had Eclipse Therapeutics, inc been acquired at the beginning of the year, the directors have: 3 calculated depreciation of plant and equipment acquired on the basis of the fair values arising in the initial accounting for the business combination rather than the carrying amounts recognised in the pre-acquisition financial statements; 3 included savings for work performed within the Group rather than outsourced; and 3 assumed a similar rate of progress for research and development. 81 DIRECTORS’ DEClARATION THE DIRECTORS DECLARE THAT: a) in the directors’ opinion, there are reasonable grounds to believe that the Company will be able to pay its debts as and when they become due and payable; b) the attached financial statements are in compliance with international financial Reporting Standards issued by the international Accounting Standards Board, as stated in note 1 to the financial statements; c) in the directors’ opinion, the attached financial statements and notes thereto are in accordance with the Corporations Act 2001, including compliance with accounting standards and giving a true and fair view of the financial position and performance of the consolidated entity; and d) the directors have been given the declarations required by section 295A of the Corporations Act 2001. Signed in accordance with a resolution of the directors made pursuant to section 295(5) of the Corporations Act 2001. On behalf of the directors Graeme Kaufman Chairman Deborah Rathjen Chief Executive Officer and Managing Director Dated this 15th day of August 2013 82 INDEPENDENT AuDIT REPORT 83 INDEPENDENT AuDIT REPORT 84 SHAREHOlDER INFORMATION All shareholder information provided is current as at 18 September 2013. DiffEREnCE in RESuLTS REpORTED TO ThE ASX There are no material differences between the figures reported in the financial statements and those lodged with the ASX in the Company’s Appendix 4E for the year ended 30 June 2013, other than those previously announced to the market. AuDiT AnD RiSk MAnAGEMEnT COMMiTTEE The Company established an Audit and Risk Management Committee in July 2002. The main responsibilities of the Audit and Risk Management Committee are set out in the section headed ‘Corporate Governance Statement’ of the Annual Report. CORpORATE GOvERnAnCE Bionomics’ corporate governance practices are set out in the section headed ‘Corporate Governance Statement’ of the Annual Report. SuBSTAnTiAL ShAREhOLDERS Substantial holders in the Company are set out below: ORDINARY SHARES Link Traders (Aust) pty Ltd John Leaver Ausbil Dexia Limited The Australian national university NUMBER HELD 34,624,622 24,241,071 24,000,000 21,642,425 EquiTY SECuRiTiES There are 4,085 holders of ordinary shares in Bionomics. The number of shareholdings held in less than marketable parcels is 249. vOTinG RiGhTS There is one class of quoted equity securities issued by the Company, ordinary, with voting rights attached to the ordinary shares. One share equates to one vote. DiSTRiBuTiOn Of hOLDERS Of EquiTY SECuRiTiES CATEGORY (SIzE OF HOLDING) ORDINARY SHARES UNLISTED OPTIONS NUMBER OF SECURITY HOLDERS 1 – 1,000 1,001 – 5,000 5,001 – 10,000 10,001 – 100,000 100,001 – and over 407 1,214 691 1,460 313 4,085 - 3 3 28 16 50 85 SHAREHOlDER INFORMATION TWEnTY LARGEST hOLDERS Of EACh CLASS Of quOTED EquiTY SECuRiTiES The names of the 20 largest holders of each class of quoted equity securities are listed below: ORDINARY SHARES NAME national nominees Limited Link 405 pty Ltd hSBC Custody nominees (Australia) Limited The Australian national university CvC Limited hSBC Custody nominees (Australia) Limited–GSCO ECA hSBC Custody nominees (Australia) Limited pagodatree investments Limited Leagou funds Management pty Ltd Wenola pty Limited Balzac investments pty Ltd City hill venture partners i LLC Mr Mark Richard potter and Mrs Rebecca Amy potter Alimter pty Limited Bnp paribas noms pty Ltd Biogen iDEC MA inc Citicorp nominees pty Limited AW & JE Wilks pty Ltd Boom Australia pty Limited Mandalay Capital pty Limited 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 UNQUOTED EQUITY SECURITIES Options issued pursuant to Bionomics Limited Employee Share Option plan NUMBER HELD 63,060,183 39,578,873 29,590,892 21,642,425 15,876,024 13,805,085 11,816,448 8,014,030 7,652,692 7,100,171 4,816,950 4,009,865 3,800,000 3,000,000 2,819,500 2,810,306 2,765,928 2,650,000 2,500,000 2,350,000 PERCENTAGE OF ISSUED SHARES 15.32 9.62 7.19 5.26 3.86 3.35 2.87 1.95 1.86 1.73 1.17 0.97 0.92 0.73 0.69 0.68 0.67 0.64 0.61 0.57 249,659,372 60.66 NUMBER ON ISSUE NUMBER OF HOLDERS 9,944,160 9,944,160 50 50 COMPANY PARTICulARS Bionomics, a listed public Company, is domiciled and incorporated in Australia. SENIOR MANAGEMENT Dr Deborah Rathjen Bionomics shares are listed on the Australian Securities Exchange under the code BnO. REGISTERED OFFICE 31 Dalgleish Street Thebarton SA Australia 5031 Telephone: +61 8 8354 6100 ADMINISTRATIVE OFFICE 31 Dalgleish Street Thebarton SA Australia 5031 Telephone: +61 8 8354 6100 Facsimile: +61 8 8354 6199 E-mail: info@bionomics.com.au Web Address: www.bionomics.com.au SHARE REGISTRY Computershare investor Services pty Limited Level 5, 115 Grenfell Street Adelaide SA Australia 5000 Telephone: 1300 556 161 (within Australia) +61 3 9415 4000 (outside Australia) E-mail: web.queries@computershare.com.au Web Address: www.computershare.com SOLICITORS Johnson Winter & Slattery 211 victoria Square Adelaide SA Australia 5000 AUDITORS Deloitte Touche Tohmatsu 11 Waymouth Street Adelaide SA Australia 5000 PATENT ATTORNEYS Griffith hack Level 10, 161 Collins Street Melbourne viC Australia 3000 Davies Collison Cave 1 nicholson Street Melbourne viC Australia 3000 Bionomics is not listed on any other stock exchanges other than the ASX. DIRECTORS Mr Graeme kaufman Chairman Dr Deborah Rathjen Chief Executive Officer and Managing Director Mr Trevor Tappenden non-Executive Director Dr Errol De Souza non-Executive Director Dr Jonathan Lim non-Executive Director Dr Emile Andriambeloson Dr peter Chu Dr forrest fuller Dr Andrew harvey Dr José iglesias Dr Gabriel kremmidiotis Dr Sue O’Connor Dr Christopher Reyes Dr Jeremy Simpson Ms Melanie Young Chief Executive Officer and Managing Director head of Research, neurofit vice president uS Operations & Cancer Biology vice president Business Development vice president Drug Discovery Chief Medical Officer vice president Research and Development Senior Director, CnS Research & Development vice president Research and Development Biologics vice president Clinical Development Chief financial Officer and Company Secretary SCIENTIFIC ADVISORS Dr Carrolee Barlow phD MD BA Dr philippe Danjou MD phD Dr Jayesh Desai fRACp Dr Errol De Souza phD professor paul fitzgerald phD MSc Dr Ann hayes phD Bsc Dr fiona McLaughlin phD fSB Dr Christopher J Sweeney MBBS Dr CD nigel Toseland fRCpath Bionomics has an American Depositary Receipts program (ADRs) sponsored by BnY Mellon, under the ticker code ‘BMiCY’. for further details about this program, please contact: UNITED STATES BnY Mellon Shareowner Services pO Box 358516, pittsburgh, pA 15252-8516 Toll Free Number for Domestic Calls: +1 888 BnY ADRS or +1888 269 2377 Number for International Calls: +1 201 680 6825 Email: shrrelations@bnymellon.com or visit BNY Mellon Shareowner Services’ website at www.bnymellon.com\shareowner AUSTRALIA Mr Anthony Sprenger, vice president BnY Mellon Depositary Receipts Australia & new Zealand The Bank of new York Level 5, 350 Collins Street, Melbourne viC 3000 Telephone: +61 3 9640 3907 Facsimile: +61 3 9602 1236 E-mail: anthony.sprenger@bnymellon.com 31 DALGLEISH STREET, THEBARTON, SA AUSTRALIA, 5031 WWW.BIONOMICS.COM.AU ABN 53 075 582 740

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