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Cryoport, Inc.

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FY2010 Annual Report · Cryoport, Inc.
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UNITED STATES  
SECURITIES AND EXCHANGE COMMISSION  
Washington, D.C. 20549  
________________________  
FORM 10-K  

(Mark One)  

 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934  
For the fiscal year ended March 31, 2010  
OR  
(cid:3) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934  
For the transition period from ______ to ______  

Commission file number: 000-51578  

  CRYOPORT, INC.  
  (Exact name of Registrant as specified in its charter)  

Nevada  
(State or other jurisdiction of incorporation or organization)  

88-0313393  
(I.R.S. Employer Identification No.)  

20382 Barents Sea Circle, Lake Forest, California  
(Address of principal executive offices)  

92630  
(Zip Code)  

(949) 470-2300  
(Registrant's telephone number, including area code)  

Securities registered pursuant to Section 12(b) of the Act:  

Title of Each Class  
Common Stock, $.001 par value  

Name of Each Exchange on Which Registered  
OTC Bulletin Board  

Securities registered pursuant to Section 12(g) of the Act:  
Common Stock, $0.001  
Warrants to Purchase Common Stock  

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.     Yes   (cid:3)    No     

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.     Yes   (cid:3)    No    

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act 
of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject 
to such filing requirements for the past 90 days.   Yes      No (cid:3)  

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data 
File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or 
for such shorter period that the registrant was required to submit and post such files).    Yes (cid:3)     No   

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405) is not contained herein, and will not 
be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this 
Form 10-K or any amendment to this Form 10-K.      

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting 
company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. 
(check one):  

Large accelerated filer   (cid:3)   

Accelerated filer   (cid:3)  

  Non-accelerated filer   (cid:3)     Smaller reporting company     

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).  Yes   (cid:3)   No     

The aggregate market value of Common Stock held by non-affiliates as of September 30, 2009 was $ 22,027,889 (1)  

 
   
 
   
   
   
   
   
   
 
 
  
  
  
Number of shares of Common Stock outstanding as of June 15, 2010: 8,150,255  

DOCUMENTS INCORPORATED BY REFERENCE  

Part III of this report incorporates certain information by reference from the registrant’s proxy statement for the annual meeting of stockholders, 
which proxy statement will be filed no later than 120 days after the close of the registrant’s fiscal year ended March 31, 2010.  
_________  
(1)   Excludes 2,630,740 shares of common stock held by directors and officers, and any stockholder whose ownership exceeds five percent of 

the shares outstanding as of September 30, 2009.  

   
   
 
 
  
  
CRYOPORT, INC.  

Fiscal Year 2010 10-K Annual Report  

Table of Contents  

PART I 

Item  1  
Item  1A  
Item  1B  
Item  2  
Item  3  
Item  4  

Business  
Risk Factors  
Unresolved Staff Comments  
Properties  
Legal Proceedings  
[Removed and Reserved]  

PART II 
Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities  
Selected Financial Data  
Management’s Discussion and Analysis of Financial Condition and Results of Operations  
Quantitative and Qualitative Disclosures About Market Risk  
Financial Statements and Supplementary Data  
Changes in and Disagreements with Accountants on Accounting and Financial Disclosures  
Controls and Procedures  
Other Information  

  PART III 

Directors, Executive Officers and Corporate Governance  
Executive Compensation  
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters  
Certain Relationships and Related Transactions, and Director Independence  
Principal Accountant Fees and Services  

Exhibits and Consolidated Financial Statement  
Schedules  

PART IV 

Item  5  
Item  6  
Item  7  
Item  7A  
Item  8  
Item  9  
Item 9A(T)  
Item 9B  

Item 10  
Item 11  
Item 12  
Item 13  
Item 14  

Item 15  

Signatures  

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13 
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25 
25 
25 

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27 
28 
37 
37 
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37 
38 

40 
40 
40 
40 
40 

41 

46 

NOTE REGARDING REVERSE STOCK SPLIT  

On February 5, 2010, we filed a Certificate of Amendment to our Articles of Incorporation with the Secretary of State of the State of 
Nevada to effect a reverse split of our common stock at a ratio of ten for one.   All historical share and per share amounts have been adjusted to 
reflect the reverse stock split.  

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PART I  

In  this  Annual  Report,  the  terms  “we”,  “us”,  “our”,  “Company”  and  “CryoPort”  refer  to  CryoPort,  Inc.,  and  our  wholly  owned 
subsidiary, CryoPort Systems, Inc.  This Annual Report contains forward-looking statements that involve risks and uncertainties.  The inclusion 
of forward-looking statements should not be regarded as a representation by us or any other person that the objectives or plans will be achieved 
because  our  actual  results  may  differ  materially  from  any  forward-looking  statement.  The  words  “may,”  “should,”  “plans,”  “believe,”
“anticipate,” “estimate,” “expect,” their opposites and similar expressions are intended to identify forward-looking statements, but the absence of 
these words does not necessarily mean that a statement is not forward-looking.  We caution readers that such statements are not guarantees of 
future performance or events and are subject to a number of factors that may tend to influence the accuracy of the statements, including but not 
limited to, those risk factors outlined in the section titled “Risk Factors” as well as those discussed elsewhere in this Annual Report.  You should 
not  unduly  rely  on  these  forward-looking  statements,  which  speak  only  as  of  the  date  of  this  Annual  Report.  We  undertake  no  obligation  to 
publicly revise any forward-looking statement to reflect circumstances or events after the date of this Annual Report or to reflect the occurrence 
of unanticipated events.  You should, however, review the factors and risks we describe in the reports that we file from time to time with the 
Securities and Exchange Commission (“SEC”) after the date of this Annual Report.  

In addition, we own or have rights to the registered trademark CryoPort® (both alone and with a design logo) and CryoPort Express® 
(both alone and with a design logo).  All other Company names, registered trademarks, trademarks and service marks included in this Annual 
Report are trademarks, registered trademarks, service marks or trade names of their respective owners.  

Item 1.     BUSINESS  

Overview  

We are a provider of an innovative cold chain frozen shipping system dedicated to providing superior, affordable cryogenic shipping 
solutions  that  ensure  the  safety,  status  and  temperature,  of  high  value,  temperature  sensitive  materials.  We  have  developed  cost  effective 
reusable  cryogenic  transport  containers  (referred  to  as  "shippers") capable  of  transporting  biological,  environmental  and  other  temperature 
sensitive materials at temperatures below 0° Celsius.  These dry vapor shippers and shipping system are one of the first significant alternatives to 
dry ice shipping and achieve 10-plus day holding times compared to one to two day holding times with dry ice.  

Our  value  proposition  comes  from  both  providing safe  transportation  with  an  environmentally  friendly,  long  lasting  shipper,  and 
through our value added services that offer a simple hassle-free solution for our customers.  These value-added services include an internet-based 
web portal that enables the customer to initiate scheduling, shipping and tracking of the progress and status of a shipment, and provides in-transit 
temperature  and  custody  transfer  monitoring  services  of  the  shipper.  The  CryoPort  service  also  provides  a  fully  ready  charged  shipper 
containing all freight bills, customs documents and regulatory paperwork for the entire journey of the shipper to our customers at their pickup 
and delivery locations.  

Our principal focus has been the further development and commercial launch of CryoPort Express® Portal, an innovative IT solution 
for  shipping  and  tracking  high-value  specimens  through  overnight  shipping  companies,  and  our  CryoPort  Express®  Shipper,  a  dry  vapor 
cryogenic  shipper  for  the  transport  of  biological  and  pharmaceutical  materials.  A  dry  vapor  cryogenic  shipper  is  a  container  that  uses  liquid 
nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide storage temperatures below minus 
150°  Celsius.  The  dry  vapor  shipper  is  designed  using  innovative,  proprietary,  and  patented  technology  which  prevents  spillage  of  liquid 
nitrogen and pressure build up as the liquid nitrogen evaporates.  A proprietary foam retention system is employed to ensure that liquid nitrogen 
stays  inside  the  vacuum  container,  even  when  placed  upside-down  or  on  its  side,  as  is  often  the  case  when  in  the  custody  of  a  shipping 
company.  Biological specimens are stored in a specimen chamber, referred to as a “well,” inside the container and refrigeration is provided by 
harmless  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen  entrapped  within  the  foam  retention  system  surrounding  the  well.  Biological 
specimens transported using our cryogenic shipper can include clinical samples, diagnostics, live cell pharmaceutical products (such as cancer 
vaccines, semen and embryos, infectious substances) and other items that require and/or are protected through continuous exposure to frozen or 
cryogenic temperatures.  

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During our early years, our limited revenue was derived from the sale of our reusable product line.  Our current business plan focuses 
on per-use  leasing  of  the  shipping  container  and  added-value  services  that  will  be  used  by  us  to  provide  an  end-to-end  and  cost-optimized 
shipping solution to life science companies moving pharmaceutical and biological samples in clinical trials and pharmaceutical distribution.  

We recently entered into our first strategic relationship with a global courier on January 13, 2010 when we signed an agreement with 
Federal Express Corporation (“FedEx”) pursuant to which we will lease to FedEx such number of our cryogenic shippers that FedEx shall, from 
time to time, order for its customers. Under this agreement, FedEx has the right to and shall, on a non-exclusive basis, promote, market and sell 
transportation of our shippers and our related value-added goods and services, such as our data logger, web portal and planned CryoPort Express 
® Smart Pak System.  

We are a  Nevada  corporation originally incorporated under the  name G.T.5-Limited (“GT5”)  on May 25, 1990. In connection with a 
Share Exchange Agreement, on March 15, 2005 we changed our name to CryoPort, Inc. and acquired all of the issued and outstanding shares of 
common stock of CryoPort Systems, Inc., a California corporation, in exchange for 2,410,811 shares of our common stock (which represented 
approximately 81% of the total issued and outstanding shares of common stock following the close of the transaction). CryoPort Systems, Inc., 
which was originally formed in 1999 as a California limited liability company, and subsequently reorganized into a California corporation on 
December 11,  2000,  remains  the  operating  company  under  CryoPort,  Inc.  Our  principal  executive  offices  are  located  at  20382  Barents  Sea 
Circle,  Lake  Forest,  California  92630. The  telephone  number  of  our  principal  executive  offices  is  (949) 470-2300,  and  our  main  corporate 
website is www.cryoport.com. The information on, or that can be accessed through, our website is not part of this Annual Report.  

Our Products and Pipeline  

Our  product  offering  and  service  offering  consists  of  our  CryoPort  Express  ®  Shippers,  reusable  dry  vapor  shippers,  the  web  portal 
allowing ease of entry and our Smart Pak data logger, a temperature monitoring system (which, together with our CryoPort Express ® Shippers, 
comprise our new business model referred to as the CryoPort Express  ® System) and a containment bag which is used in connection with the 
shipment of infectious or dangerous goods using the CryoPort Express ® Shipper.  

  The CryoPort Express® Shippers  

            Our CryoPort Express® Shippers are cryogenic dry vapor shippers capable of maintaining cryogenic temperatures of minus 150° Celsius 
or  below  for  a  period  of  10  or  more  days.  A  dry  cryogenic  shipper  is  a  device  that  uses  liquid  nitrogen  contained  inside  a  vacuum  insulated 
bottle which serves as a refrigerant to provide storage temperatures below minus 150° Celsius.  Our CryoPort Express® shipper is designed to 
ensure that there is no pressure build up as the liquid nitrogen evaporates or spillage of liquid nitrogen.  We have developed a proprietary foam 
retention  system  to  ensure  that  liquid  nitrogen  stays  inside  the  vacuum  container,  which  allows  the  shipper  to  be  designated  as  a  dry  shipper 
meeting  International  Air  Transport  Association  (“IATA”)  requirements.  Biological  or  pharmaceutical  specimens  are  stored  in  a  specimen 
chamber,  referred  to  as  a  “well”,  inside  the  container  and  refrigeration  is  provided  by  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen 
entrapped  within  the  foam  retention  system.  Specimens that  may  be  transported  using  our  cryogenic  shipper  include live  cell  pharmaceutical 
products  such  as  cancer  vaccines,  diagnostic  materials,  semen  and  embryos,  infectious  substances  and  other  items  that  require  continuous 
exposure to frozen or cryogenic temperatures (e.g., temperatures below minus 150° Celsius).  

The  technology  underlying  the  CryoPort  Express®  Shipper  was  developed  by  modifying  and  advancing  technology  from  our  first 
generation of reusable cryogenic dry shippers.  While our CryoPort Express® Shippers share many of the characteristics and basic design details 
of our earlier shippers, we are manufacturing our CryoPort Express® Shippers from alternative, lower cost and lower weight materials, which 
will reduce overall operating costs.  We maintain ongoing development efforts related to our shippers which are principally focused on material 
properties, particularly those properties related to the low temperature requirement, the vacuum retention characteristics, such as the permeability 
of the materials, and lower cost and lower weight materials in an effort to meet the market needs for achieving a lower cost frozen and cryogenic 
shipping  solution.  Other  advances  additional  to  the  development  work  on  the  cryogenic  container  include  both  an  improved  liquid  nitrogen 
retention  system  and a  secondary  protective, spill  proof  packaging  system.  This  secondary system,  outer packaging  has  a  low  cost that  lends 
itself to disposability, and it is made of recyclable materials.  Further, it adds an additional liquid nitrogen retention capability to further assure 
compliance  with  IATA  and  ICAO  regulations  that  prohibit  egress  of  liquid  nitrogen  from  the  shipping  package.  IACO  stands  for  the 
International Civil Aviation Organization, which is a United Nations organization that develops regulations for the safe transport of dangerous 
goods by air.  

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Our  CryoPort  Express®  Shippers  are  lightweight,  low-cost,  re-usable  dry  vapor  liquid  nitrogen  storage  containers  that  we  believe 
combine the best features of packaging, cryogenics and high vacuum technology.  A CryoPort Express® Shipper is composed of an aluminum 
metallic dewar flask, with a well for holding the biological material in the inner chamber.  The dewar flask, or “thermos bottle,” is an example of 
a practical device in which the conduction, convection and radiation of heat are reduced as much as possible.  The inner chamber of the shipper 
is surrounded by a high surface, low-density open cell plastic foam material which retains the liquid nitrogen in-situ by absorption, adsorption 
and surface tension.  Absorption is defined as the taking up of matter in bulk by other matter, as in the dissolving of a gas by a liquid, whereas 
adsorption  is  the  surface  retention  of  solid,  liquid  or  gas  molecules,  atoms  or  ions  by  a  solid  or  liquid.  This  material  absorbs  liquid  nitrogen 
several  times  faster  than  currently  used  materials,  while  providing  the  shipper  with  a  hold  time  and  capacity  to  transport  biological  materials 
safely and conveniently.  The annular space between the inner and outer dewar chambers is evacuated to a very high vacuum (10-6 Torr).  The 
specimen-holding chamber has a primary cap to enclose the specimens, and a removable and replaceable secondary cap to further enclose the 
specimen-holding  container  and  to  contain  the  liquid  nitrogen.  The  entire  dewar  vessel  is  then  wrapped  in  a  plurality  of  insulating  and 
cushioning materials and placed in a disposable outer packaging made of recyclable material.  

            We believe the CryoPort solution is the best and most cost effective solution available in the market that satisfies customer needs and 
regulatory  requirements  relating  to  the  shipment  of  temperature-critical,  frozen  and  refrigerated  transport  of  biological  materials,  such  as  the 
pharmaceutical  clinical  trials,  gene  biotechnology,  infectious  materials  handling,  and  animal  and  human  reproduction  markets.  Due  to  our 
proprietary technology and innovative design, our shippers are less prone to losing functional hold time when not kept in an upright position than 
the competing products because such proprietary technology and innovative design prevent the spilling or leakage of the liquid nitrogen when 
the container is tipped or on its side which would adversely affect the functional hold time of the container.  

            An important feature of the CryoPort Express® Shippers is their compliance with the stringent packaging requirements of IATA Packing 
Instructions 602 and 650, respectively.  These instructions include the internal pressure (hydraulic) and drop performance requirements.  

  The CryoPort Express ® System  

The  CryoPort  Express®  System  is  comprised  of  the  CryoPort  Express  ®  Shipper  ,  the  CryoPort  Express  ®  Smart  Pak  data  logger, 
CryoPort  Express  ®  Portal,  which  programmatically  manages  order  entry  and  all  aspects  of  shipping  operations,  and  CryoPort  Express  ® 
Analytics,  which  monitors  shipment  performance  metrics  and  evaluates  temperature-monitoring  data  collected  by  the  data  logger  during 
shipment.  The  CryoPort  Express®  System  is  focused  on  improving  the  reliability  of  frozen  shipping  while  reducing  the  customers’  overall 
operating costs.  This is accomplished by providing a complete end-to-end solution for the transport and monitoring of frozen or cryogenically 
preserved biological or pharmaceutical materials shipped though overnight shipping companies.  

  CryoPort Express ® Portal  

The CryoPort Express® Portal is used by CryoPort, our customers and our business partners to automate the entry of orders, prepare 
customs  documentation  and  to  facilitate  status  and  location  monitoring  of  shipped  orders  while  in  transit.  As  an  example, the  CryoPort 
Express® Portal is fully integrated with IT systems at FedEx and runs in a browser requiring no software installation.  It is used by CryoPort to 
manage  shipping  operations  and  to  reduce  administrative  costs  typically  provisioned  through  manual  labor  relating  to  order-entry,  order 
processing, preparation of shipping documents and back-office accounting. It is also used to support the high level of customer service expected 
by  the  industry. Certain  features  of the CryoPort Express®  Portal reduce  operating  costs and  facilitate  the scaling  of  CryoPort’s business,  but 
more importantly they offer significant value to the customer in terms of cost avoidance and risk mitigation.  Examples these features include 
automation of order entry, development of Key Performance Indicators (“KPI”) to support our efforts for continuous process improvements in 
our  business,  and  programmatic  exception  monitoring  to  detect  and  sometimes  anticipate  delays  in  the  shipping  process,  often  before  the 
customer  or  the  shipping  company  becomes  aware  of  it.  In  the  future  we  will  add  rate  and  mode  optimization  and  in-transit  monitoring  of 
temperature, location and state of health (discussed below), via wireless communications.  

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The CryoPort  Express®  Portal also serves  as the communications nerve center for the management, collection and analysis of Smart 
Pak data harvested from Smart Pak data loggers in the field. Data is converted into pre-designed reports containing valuable and often actionable 
information that becomes the quality control standard or “pedigree” of the shipment.  This high value information can be utilized by CryoPort to 
provide consultative services to the customer relating to cryogenics.  

  The CryoPort Express ® Smart Pak  

Temperature monitoring is a high value feature from our customers' perspective as it is an effective and reliable method to determine 
that the shipment materials were not damaged or degraded during shipment due to temperature fluctuations.  Phase II of our Smart Pak System 
which is a self-contained automated data logger capable of recording the internal and external temperatures of samples shipped in our CryoPort 
Express® Shipper was launched in fiscal year 2010.  

Phase III of our Smart Pak System is anticipated to launch in fiscal year 2011, and consists of adding a smart chip to each shipper with 
wireless  connectivity  to  enable  our  customers  to  monitor  a  shipper’s  location,  specimen  temperature  and  overall  state  of  health  via  our  web 
portal.  A key feature of the Phase III product is automatic downloading of data which requires no customer intervention.  

  CryoPort Express ® Analytics  

Our continued development of the CryoPort Express® Portal is a strategic element of our business strategy and the CryoPort Express® 
Portal system has been designed to support planned future features with this thought in mind.  Analytics is a term used by IT professionals to 
refer  to  performance  benchmarks  or  Key  Performance  Indicators  (KPI’s)  that  management  utilizes  to  measure  performance  against  desired 
standards. Examples include time-based metrics for order processing time and on-time deliveries by our shipping partners, as well as profiling 
shipping lanes to determine average transit times and  predicting an exception if a shipment is taking longer than it should based on historical 
metrics.  The analytical results will be utilized by CryoPort to render consultative customer services.    

  Biological Material Holders  

            We  have  also  developed  a  patented  containment  bag  which  is  used  in  connection  with  the  shipment  of  infectious  or  dangerous  goods 
using  the  CryoPort  Express®  Shipper.   Up  to  five  vials,  watertight  primary  receptacles,  are  placed  onto  aluminum  holders  and  up  to  fifteen 
holders (75 vials) are placed into an absorbent pouch which is designed to absorb the entire contents of all the vials in the event of leakage.  This 
pouch containing up to 75 vials is then placed in a watertight secondary packaging Tyvek bag capable of withstanding cryogenic temperatures, 
and then sealed.   This bag is then placed into the well of the cryogenic shipper.  

Other Product Candidates and Development Activities  

We are continuing our research and development efforts which are expected to lead to the introduction of additional dry vapor shippers, 
including  larger  and  smaller  size  units  constructed  of  lower  cost  materials  and  utilizing  high  volume  manufacturing  methods.  We  are  also 
exploring the use of alternative phase change materials in place of liquid nitrogen in order to seek entry into the ambient temperature and chilled 
(2° to 8° Celsius) shipping markets.  

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Government Regulation  

The shipping of diagnostic specimens, infectious substances and dangerous goods, whether via air or ground, falls under the jurisdiction 
of  many  states,  federal  and  international  agencies. The  quality  of  the  containers,  packaging  materials  and  insulation  that  protect  a  specimen 
determine whether or not it will arrive in a usable condition. Many of the regulations for transporting dangerous goods in the United States are 
determined  by  international  rules  formulated  under  the  auspices  of  the  United  Nations. For  example,  the  ICAO  is  the  United  Nations 
organization that develops regulations (Technical Instructions) for the safe transport of dangerous goods by air. If shipment is by air, compliance 
with  the  rules  established  by  IATA  is  required. IATA  is  a  trade  association  made  up  of  airlines  and  air  cargo  couriers  that  publishes  annual 
editions of the IATA Dangerous Goods Regulations. These regulations interpret and add to the ICAO Technical Instructions to reflect industry 
practices. Additionally, the CDC has regulations (published in the Code of Federal Regulations) for interstate shipping of specimens, and OSHA 
also  addresses  the  safe  handling  of  Class  6.2  Substances. Our  CryoPort  Express  ®  Shipper  meets  Packing  Instructions  602  and  650  and  is 
certified  for  the  shipment  of  Class  6.2  Dangerous  Goods  per  the  requirements  of  the  ICAO  Technical  Instructions  for  the  Safe  Transport  of 
Dangerous Goods by Air  and  IATA. Our  present  and planned  future versions  of the CryoPort Smart  Pak data  logger will likely be  subject  to 
regulation by FAA, FCC, FDA, IATA and possibly other agencies which may be difficult to determine on a global basis.  

We are also subject to numerous other federal, state and local laws relating to such matters as safe working conditions, manufacturing 
practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. We may incur significant 
costs to comply with such laws and regulations now or in the future.  

Manufacturing and Raw Materials  

Manufacturing.   The component parts for our products are primarily manufactured at third party manufacturing facilities. We also have 
a  warehouse  at  our  corporate  offices  in  Lake  Forest,  California,  where  we  are  capable  of  manufacturing  certain  parts  and  fully  assemble  our 
products. Most of the components that we use in the manufacture of our products are available from more than one qualified supplier. For some 
components, however, there are relatively few alternate sources of supply and the establishment of additional or replacement suppliers may not 
be  accomplished  immediately,  however,  we  have  identified  alternate  qualified  suppliers  which  we  believe  could  replace  existing 
suppliers. Should this occur, we believe that with our current level of dewars and production rate we have enough to cover a four to six week gap 
in   maximum disruption of production.  

Primary  manufacturers  used  by  us  include  Spaulding  Composites  Company,  Peterson  Spinning  and  Stamping,  Lydall  Industrial 
Thermal Solutions, and Ludwig, Inc. There are no specific agreements with any manufacturer nor are there any long term commitments to any 
manufacturer. We  believe  that  most  of  the  manufactures  currently  used by  us  could  be  replaced  within  a  short  period  of time  as  none  have a 
proprietary component or a substantial capital investment specific to our products.  

Our production and manufacturing process incorporates innovative technologies developed for aerospace and other industries which are 
cost  effective,  easier  to  use  and  more  functional  than  the  traditional  dry  ice  devices  and  other  methods  currently  used  for  the  shipment  of 
temperature-sensitive  materials. Our  manufacturing  process  uses  non-hazardous  cleaning  solutions  which  are  provided  and  disposed  of  by  a 
supplier approved by the Environmental Protection Agency (the “EPA”). EPA compliance costs for us are therefore negligible.  

Raw  Materials.    Various  common  raw  materials  are  used  in  the  manufacture  of  our  products  and  in  the  development  of  our 
technologies.  These  raw materials are generally available from several alternate distributors and manufactures.  We have not experienced any 
significant difficulty in obtaining these raw materials and we do not consider raw material availability to be a significant factor in our business.  

5 

 
 
 
 
 
 
 
 
 
 
 
  
  
Patents and Proprietary Rights  

In order to remain competitive, we must develop and maintain protection on the proprietary aspects of its technologies. We rely on a 
combination of patents, copyrights, trademarks, trade secret laws and confidentiality agreements to protect our intellectual property rights. We 
currently own four registered United States trademarks and three issued United States patents primarily covering various aspects of our products. 
In addition, we have filed a patent application for various aspects of our shipper and web-portal, which includes, in part, various aspects of our 
business model referred to as the CryoPort Express® System, and we intend to file additional patent applications to strengthen our intellectual 
property rights. The technology covered by the above indicated issued patents relates to matters specific to the use of liquid nitrogen dewars in 
connection with the shipment of biological materials. The concepts include those of disposability, package configuration details, liquid nitrogen 
retention  systems,  systems  related  to  thermal  performance,  systems  related  to  packaging  integrity,  and  matters  generally  relevant  to  the 
containment  of  liquid  nitrogen.  Similarly,  the  trademarks  mentioned  relate  to  the  cryogenic  temperature  shipping  activity.  Issued  patents  and 
trademarks currently owned by us include:  

   Type:  
   Patent  
   Patent  
   Patent  
   Trademark  
   Trademark  
   Trademark  
   Trademark  

No.  
6,467,642  
6,119,465  
6,539,726  
7,583,478,7  
7,586,797,8  
7,748,667,3  
7,737,451,1  

Issued  
Oct. 22, 2002  
Sep. 19, 2000  
Apr. 1, 2003  
Oct. 9, 2002  
Apr. 16, 2002  
Feb. 3, 2009  
Mar. 17, 2009  

Expiration  
Oct. 21, 2022  
Sep. 18, 2020  
Mar 31, 2023  
Oct. 8, 2012  
Apr. 16, 2012  
Feb. 3, 2019  
Mar. 17, 2019  

Our  success  depends  to  a  significant  degree  upon  our  ability  to  develop  proprietary  products  and  technologies  and  to  obtain  patent 
coverage  for  these  products  and  technologies.  We  intend  to  file  trademark  and  patent  applications  covering  any  newly  developed  products, 
methods  and  technologies.  However,  there  can  be  no  guarantee  that  any  of  our  pending  or  future  filed  applications  will  be  issued  as  patents. 
There can be no guarantee that the U.S. Patent and Trademark Office or some third party will not initiate an interference proceeding involving 
any of our pending applications or issued patents. Finally, there can be no guarantee that our issued patents or future issued patents, if any, will 
provide adequate protection from competition.  

Patents provide some degree of protection for our proprietary technology. However, the pursuit and assertion of patent rights involve 
complex  legal  and  factual  determinations  and,  therefore,  are  characterized  by  significant  uncertainty.  In  addition,  the  laws  governing  patent 
issuance  and  the  scope  of  patent  coverage  continue  to  evolve.  Moreover,  the  patent  rights  we  possess  or  are  pursuing  generally  cover  our 
technologies to varying degrees. As a result, we cannot ensure that patents will issue from any of our patent applications, or that any of its issued 
patents will offer meaningful protection. In addition, our issued patents may be successfully challenged, invalidated, circumvented or rendered 
unenforceable so that our patent rights may not create an effective barrier to competition. Moreover, the laws of some foreign countries may not 
protect our proprietary rights to the same extent, as do the laws of the United States. There can be no assurance that any patents issued to us will 
provide  a  legal  basis  for  establishing  an  exclusive  market  for  our  products  or  provide  us  with  any  competitive  advantages,  or  that  patents  of 
others will not have an adverse effect on our ability to do business or to continue to use our technologies freely.  

We  may  be  subject  to  third  parties  filing  claims  that  our  technologies  or  products  infringe  on  their  intellectual  property.  We  cannot 
predict whether third parties will assert such claims against us or whether those claims will hurt our business. If we are forced to defend against 
such claims, regardless of their merit, we may face costly litigation and diversion of management’s attention and resources. As a result of any 
such disputes,  we may  have to  develop,  at  a  substantial cost, non-infringing  technology or enter into licensing agreements. These agreements 
may be unavailable on terms acceptable to it, or at all, which could seriously harm our business or financial condition.  

6 

 
 
 
 
   
 
 
 
 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
We also rely on trade secret protection of our intellectual property. We attempt to protect trade secrets by entering into confidentiality 
agreements with third parties, employees and consultants, although, in the past, we have not always obtained such agreements. It is possible that 
these  agreements  may  be  breached,  invalidated  or  rendered  unenforceable,  and  if  so,  our  trade  secrets  could  be  disclosed  to  our  competitors. 
Despite the measures we have taken to protect our intellectual property, parties to such agreements may breach confidentiality provisions in our 
contracts or infringe or misappropriate our patents, copyrights, trademarks, trade secrets and other proprietary rights. In addition, third parties 
may  independently  discover  or  invent  competitive  technologies,  or  reverse  engineer  our  trade  secrets  or  other  technology.  Therefore,  the 
measures we are taking to protect our proprietary technology may not be adequate.  

Customers and Distribution  

As a result of growing globalization, including with respect to such areas as life science clinical trials and distribution of pharmaceutical 
products, the requirement for effective solutions for keeping certain clinical samples and pharmaceutical products at frozen temperatures takes 
on  added  significance  due  to  extended  shipping  times,  custom  delays  and  logistics  challenges. Today,  such  goods  are  traditionally  shipped  in 
Styrofoam  cardboard  insulated  containers  packed  with  dry  ice,  gel/freezer  packs  or  a  combination  thereof. The  current  dry  ice  solutions  have 
limitations  that  severely  limit  their  effective  and  efficient  use  for  both  short  and  long-distances  (e.g.,  international). Conventional  dry  ice 
shipments often require labor intensive “re-icing” operations resulting in higher labor and shipping costs.  

We  believe  our  patented  cryogenic  shippers  make  us  well  positioned  to  take  advantage  of  the  growing  demand  for  effective  and 
efficient international transport of temperature sensitive materials resulting from continued globalization. Of particular significance is the trend 
within  the  pharmaceutical  and  biotechnology  industries toward  globalization. We  believe  this  presents  a  new  and  unique  opportunity  for 
pharmaceutical  companies,  particularly  early  or  developmental  stage  companies,  to  conduct  some  of  their  clinical  trials  in  foreign  countries 
where the cost may be cheaper and/or because the foreign countries significantly larger population provides a larger pool of potential patients 
suffering from the indication that the drug candidate is being designed to treat. We also plan to provide domestic shipping solutions in situations 
and regions where there is a high priority placed on maintaining the integrity of materials shipped at cryogenic temperatures and where we can 
be cost effective.  

To  date,  most  of  our  customers  have  been  in  the  pharmaceutical  or  medical  industries. As  we  initially  focus  our  efforts  to  increase 
revenues,  we  believe  that  the  primary  target  customers  for  our CryoPort  Express  ®  System  are  concentrated  in  the  following  markets,  for  the 
following reasons:  

•      Pharmaceutical clinical trials / Contract Research Organizations;  
•      Gene biotechnology;  
•      Transport of infectious materials and dangerous goods;  
•      Pharmaceutical distribution; and  
•      Fertility clinics/artificial insemination.  

Pharmaceutical Clinical Trials.     Every pharmaceutical company developing a new drug must be approved by the FDA who conducts clinical 
trials  to,  among  other  things,  test  the  safety  and  efficacy  of  the  potential  new  drug. Presently,  a  significant  amount  of  clinical  trial  activity  is 
managed by a number of large Clinical Research Organizations (“CROs”). Due to the growing downsizing trend in the pharmaceutical industry, 
CROs are going to obtain an increasing share of the clinical trial market.  

In  connection  with  the  clinical  trials,  due  to  globalization  the  companies  may  enroll  patients  from  all  over  the  world  who  regularly 
submit a blood or other specimen at the local hospital, doctor’s office or laboratory. These samples are then sent to specified testing laboratories, 
which  may  be  local  or  in  another  country. The  testing  laboratories  will  typically  set  the  requirements  for  the  storage  and  shipment  of  blood 
specimens. In addition, several of the drugs used by the patients require frozen shipping to the sites of the clinical trials. While both domestic and 
international shipping of these specimens is accomplished using dry ice today, international shipments especially present several problems, as 
dry ice, under the best of circumstances, can only provide freezing for one to two days, in the absence of re-icing (which is quite costly). Because 
shipments of packages internationally can take longer than one to two days or be delayed due to flight cancellations, incorrect destinations, labor 
problems, ground logistics, customs delays and safety reasons, dry ice is not always a reliable and cost effective option. Clinical trial specimens 
are often irreplaceable because each one represents clinical data at a prescribed point in time, in a series of specimens on a given patient, who 
may be participating in a trial for years. Sample integrity during the shipping process is vital to retaining the maximum number of patients in 
each trial. Our shippers are ideally suited for this market, as our longer hold time ensures that specimens can be sent over long distances with 
minimal  concern  that  they  will  arrive  in  a  condition  that  will  cause  their  exclusion  from  the  trial. There  are  also  many  instances  in  domestic 
shipments where the CryoPort Express ® Shipper will provide higher reliability and be cost effective.  

 
 
 
 
 
 
   
 
 
 
 
  
  
  
  
  
  
  
7 

Furthermore, the IATA requires that all airborne shipments of laboratory specimens be transmitted in either IATA Instruction 650 or 
602 certified packaging. We have developed and obtained IATA certification of the CryoPort Express ® System, which is ideally suited for this 
market, in particular due to the elimination of the cost to return the reusable shipper.  

Gene Biotechnology.     The gene biotechnology market includes basic and applied research and development in diverse areas such as stem cells, 
cloning, gene therapy, DNA tumor vaccines, tissue engineering, genomics, and blood products. Company’s participating in the foregoing fields 
rely on the frozen transport of specimens in connection with their research and development efforts, for which our CryoPort Express ® Shippers 
are ideally suited.  

Transport of Infectious Materials and Dangerous Goods.     The transport of infectious materials must be classified as such and must maintain 
strict adherence to regulations that protect public safety while maintaining the viability of the material being shipped. Some blood products are 
considered infective and must be treated as such. Pharmaceutical companies, private research laboratories and hospitals ship tissue cultures and 
microbiology  specimens,  which  are  also  potentially  infectious  materials,  between  a  variety  of  entities,  including  private  and  public  health 
reference  laboratories. Almost  all  specimens  in  this  infectious  materials  category  require  either  a  refrigerated  or  a  frozen  environment. We 
believe our CryoPort Express ® Shipper is ideally suited to meet the shipping requirements of this market.  

Partly in response to the attack on the World Trade Center and the anthrax scare, government officials and health care professionals are 
focusing  renewed  attention  on  the  possibility  of  attacks  involving  biological  and  chemical  weapons  such  as  anthrax,  smallpox  and  sarin 
gas. Efforts  expended  on  research  and  development  to  counteract  biowarfare  agents  requires  the  frozen  transport  of  these  agents  to  and  from 
facilities conducting the research and development. Vaccine research, including methods of vaccine delivery, also requires frozen transport. We 
believe our CryoPort Express ® Shipper is ideally suited to this type of research and development.  

Pharmaceutical Distribution.     The current focus for the CryoPort Express ® System also includes the area of pharmaceutical distribution. There 
are a significant number of therapeutic drugs and vaccines currently or soon to be, undergoing clinical trials. After the FDA approves them for 
commercial marketing, it will be necessary for the manufacturers to have a reliable and economical method of distribution to the physician who 
will administer the product to the patient. Although there are not now a large number of drugs requiring cryogenic transport, there are a number 
in  the  development  pipeline. It  is  likely  that  the  most  efficient  and  reliable  method  of  distribution  will  be  to  ship  a  single  dosage  to  the 
administering physician. These drugs are typically identified to individual patients and therefore will require a complete tracking history from 
the manufacturer to the patient. The most reliable method of doing this is to ship a unit dosage specifically for each patient. Because the drugs 
require  maintenance  at  frozen  or  cryogenic  temperatures,  each  such  shipment  will  require  a  frozen  or  cryogenic  shipping  package. CryoPort 
anticipates being in a position to service that need.  

Fertility  Clinics.      We  estimate  that  artificial  insemination  procedures  in  the  United  States  account  for  at  least  50,000  doses  of  semen 
annually. Since  relatively few  sperm banks  provide  donor  semen,  frozen     shipping  is almost  always  involved. As  with  animal  semen,  human 
semen must be stored and shipped at cryogenic temperatures to retain viability, stabilize the cells, and ensure reproducible results. This can only 
be accomplished with the use of liquid nitrogen or LN2 dry vapor shippers. CryoPort anticipates that this market will continue to increase as this 
practice gains acceptance in new areas of the world.  

8 

 
 
 
 
 
 
 
 
 
  
  
In addition to the above markets, our longer-term plans include expanding into new markets including, the diagnostics, food, 

environmental, semiconductor and petroleum industries.  

Sales and Marketing  

   We currently have one internal sales person who manages our direct sales.  Our current distribution channels cover the Americas, 
Europe and Asia. During the fiscal year ended March 31, 2010, annual net revenues from BD Biosciences and CDx Holdings, Inc. accounted for 
32.1% and 18.7%, respectively, of our net revenues.  

Our geographical sales for the year ended March 31, 2010 were as follows:  

USA  
Europe  
Canada  

43.6%   
52.3%   
4.1%   

We  recently  entered  into  an  agreement  with  FedEx  and  we  plan  to  further  expand  our  sales  and  marketing  efforts  through  the 
establishment of additional strategic relationships with global couriers and, subject to available financial resources, the hiring of additional sales 
and marketing personnel.  

Industry and Competition  

Our  products  and  services  are  sold  into  a  rapidly  growing  niche  of  the  packaging  industry  focused  on  the  temperature  sensitive 
packaging and shipping of biological materials. Expenditures for “value added” packaging for frozen transport have been increasing for the past 
several  years  and,  due  in  part  to  continued  globalization,  are  expected  to  continue  to  increase  even  more  in  the  future  as  more  domestic  and 
international biotechnology firms introduce pharmaceutical products that require continuous refrigeration at cryogenic temperatures. We believe 
this will require a greater dependence on passively controlled temperature transport systems (i.e., systems having no external power source).  

We  believe  that  growth  in  the  following  markets  has  resulted  in  the  need  for  increased  efficiencies  and  greater  flexibility  in  the 

temperature sensitive packaging market:  

•  
•  
•  
•  
•  
•  
•  
•  
•  
•  

Pharmaceutical clinical trials, including transport of tissue culture samples;  
Pharmaceutical commercial product distribution;  
Transportation of diagnostic specimens;  
Transportation of infectious materials;  
Intra laboratory diagnostic testing;  
Transport of temperature-sensitive specimens by courier;  
Analysis of biological samples;  
Environmental sampling;  
Gene and stem cell biotechnology and vaccine production; and  
Food engineering.  

Many of the biological products in these above markets require transport in a frozen state as well as the need for shipping containers 
which  have  the  ability  to  maintain  a  frozen,  cryogenic  environment  (e.g.,  minus  150°  Celsius)  for  a  period  ranging  from  two  to  ten  days 
(depending  on  the  distance  and  mode  of  shipment). These  products  include  semen,  embryo,  tissue,  tissue  cultures,  cultures  of  viruses  and 
bacteria,  enzymes,  DNA  materials,  vaccines  and  certain  pharmaceutical  products. In  some  instances,  transport  of  these  products  requires 
temperatures at, or approaching, minus 196° Celsius.  

9 

 
 
 
   
 
 
   
 
 
 
   
 
 
 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
One  problem  faced  by  many  companies  operating  in  these  specialized  markets  is  the  limited  number  of  cryogenic  shipping  systems 
serving their needs, particularly in the areas of pharmaceutical companies conducting clinical trials. The currently adopted protocol and the most 
common method for packaging frozen transport in these industries is the use of solid state carbon dioxide (dry ice). Dry ice is used extensively in 
shipping  to  maintain  a  frozen  state  for  a  period  of  one  to  four  days. Dry  ice  is  used  in  the  transport  of  many  biological  products,  such  as 
pharmaceuticals, laboratory specimens and certain infectious materials that do not require true cryogenic temperatures. The common approach to 
shipping  these  items  via  ground  freight  is  to  pack  the  product  in  a  container,  such  as  an  expanded  polystyrene  (Styrofoam)  box  or  a  molded 
polyurethane box, with a variable quantity of dry ice. The box is taped or strapped shut and shipped to its destination with freight charges based 
on its initial shipping weight.  

With respect to shipments via specialized courier services, there is no standardized method or device currently in use for the purpose of 
transporting  temperature-sensitive  frozen  biological  specimens. One  common  method  for  courier  transport  of  biological  materials  is  to  place 
frozen specimens, refrigerated specimens, and ambient specimens into a compartmentalized container, similar in size to a 55 quart Coleman or 
Igloo  cooler. The  freezer  compartment  in  the  container  is  loaded  with  a  quantity  of  dry  ice  at  minus  78°  Celsius,  while  the  refrigerated 
compartment at 8° Celsius utilizes ice substitutes.  

Two  manufacturers  of  the  polystyrene  and  polyurethane  containers  frequently  used  in  the  shipping  and  courier  transport  of  dry  ice 
frozen specimens are Insulated Shipping Containers, Inc. and Tegrant (formerly SCA Thermosafe). When these containers are used with dry ice, 
the average sublimation rate (e.g., the rate at which dry ice turns from a solid to a gaseous state) in a container with a 1  1 /2 inch wall thickness is 
slightly less than three pounds per 24 hours. Other existing refrigerant systems employ the use of gel packs and ice substitutes for temperature 
maintenance. Gels and eutectic solutions (phase changing materials) with a wide range of phasing temperatures have been developed in recent 
years to meet the needs of products with varying specific temperature control requirements.  

The use of dry ice and ice substitutes, however, regardless of external packaging used, are frequently inadequate because they do not 
provide low enough storage temperatures and, in the case of dry ice, last for only a few days without re-icing. As a result, companies run the risk 
of increased costs due to lost specimens and additional shipping charges due to the need to re-ice.  

Some of the other disadvantages to using dry ice for shipping or transporting temperature sensitive products are as follows:  

•  
•  
•  
•  
•  
•  

•  
•  

Availability of a dry ice source;  
Handling and storage of the dry ice;  
Cost of the dry ice;  
Compliance with local, state and federal regulations relating to the storage and use of dry ice;  
Weight of containers when packed with dry ice;  
Securing a shipping container with a high enough R-value (which is a measure of thermal resistance) to hold the dry ice and 
product for the required time period;  
Securing a shipping container that meets the requirements of IATA, the DOT, the CDC, and other regulatory agencies; and  
The emission of green house gases into the environment.  

Due to the limitations of dry ice, shipment of specimens at true cryogenic temperatures can only be accomplished using liquid nitrogen 
dry vapor shippers, or by shipping over actual liquid nitrogen. While such shippers provide solutions to the issues encountered when shipping 
with dry ice, they too are experiencing some criticisms by users or potential users. For example, the cost for these products typically can range 
from $650 to $3,000 per unit, which can substantially limit their use for the transport of many common biologics, particularly with respect to 
small  quantities  such  as  is  the  case  with  direct  to  the  physician  drug  delivery. Because  of  the  initial  cost  and  limited  production  of  these 
containers,  they  are  designed  to  be  reusable. However,  the  cost  of  returning  these  heavy  containers  can  be  significant,  particularly  in 
international markets, because most applications require only one-way shipping. We expect to provide a cost effective solution compared to dry 
ice. We believe we will provide an overall cost savings of 10% to 20% for international and specialty shipments compared to dry ice, while at 
the same time providing a higher level of support and related services.  

10 

 
 
 
 
 
 
   
 
 
 
  
  
  
  
  
  
  
  
  
  
Another problem with these existing systems relates to the hold time of the unit in a normal, upright position versus the hold time when 
the  unit  is  placed  on  its  side  or  inverted. If  a  container  is  laying  on  its  side  or  is  inverted  the  liquid  nitrogen  is  prone  to  leaking  out  of  the 
container  due  to  a  combination  of  factors,  including  a  shift  in  the  equilibrium  height  of  the liquid  nitrogen  in  the  absorbent  material and  the 
relocation of the point of gravity, which affects the hold time and compromises the dependability of the dry shipper, particularly when used in 
circumstances requiring lengthy shipping times. Due to the use of our proprietary technology, our CryoPort Express ® Shippers are not prone to 
leakage when on their side or inverted, thereby protecting the integrity of our shipper’s hold time.  

Within  our  intended  markets  for  our  CryoPort  Express®  Shippers,  there  is  limited  known  competition.  We  intend  to  become 
competitive by  reason of our improved technology in our products and through the use of our service enabled business model.  The CryoPort 
Express®  System  provides  a  simple  and  cost  effective  solution  for  the  frozen  or  cryogenic  transport  of  biological  or  pharmaceutical 
materials.  This  solution  if  comprised  of  our  innovative  dewar  and  is  supported  by  the  CryoPort  Express®  Portal,  our  web-based  order-entry 
system,  which  manages  the  scheduling  and  shipping  of  the  CryoPort  Express®  Shippers.  In  addition  to  the  traditional  dry  ice  shipping, 
suppliers, such as MVE/Chart Industries, Taylor Wharton and Air Liquide, offer various models of dry vapor liquid nitrogen shippers that are 
not cost efficient for multi-use and multi-shipment purposes due to their significantly greater unit costs and unit weight (which may substantially 
increase the shipping cost).  On the other hand, they are more established and have larger organizations and have greater financial, operational, 
sales and marketing resources and experience in research and development than we do.  Factors that we believe give us a competitive advantage 
are  attributable to  our  shipping  container  which  allows  our  shipper to retain  liquid  nitrogen  when  placed  in  non-upright  positions,  the overall 
“leak-proofness” of the our package which determines compliance with shipping regulations and the overall weight and volume of the package 
which determines shipping costs, and our business model represented by the merged integration of our shipper with CryoPort Express Portal and 
Smart Pak datalogger into a seamless shipping, tracking and monitoring solution.  Other companies that offer potentially competitive products 
include Industrial Insulation Systems, which offers cryogenic transport units and has partnered with Marathon Products Inc., a manufacturer and 
global supplier of wireless temperature data collecting devices used for documenting environmentally sensitive products through the cold chain 
and  Kodiak  Thermal  Technologies,  Inc.  which  offers,  among  other  containers,  a repeat  use  active-cool container  that  uses  free  piston  stirling 
cycle technology.  While  not  having  their  own  shipping  devices,  BioStorage  Technologies  is potentially  a  competitive  company  through  their 
management services offered for cold-chain logistics and long term biomaterial storage.  Cryogena offers a single use disposable LN2 shipper 
with  better  performance  than  dry-ice,  but  it  does  not  perform  as  well  and  is  not  as  cost-effective  as  the  CryoPort  solution  when  all  costs  are 
considered. In addition, BioMatrica, Inc. is developing and offering technology that stabilizes biological samples and research materials at room 
temperature.  They presently offer these technologies primarily to research and academic institutions, however, their technology may eventually 
enter the broader cold-chain market.  

Research and Development  

Our research and development efforts are focused on continually improving the features of the CryoPort Express® System including the 
web based customer service portal and the CryoPort Express® Shippers. Further these efforts are expected to lead to the introduction of shippers 
of varying sizes based on market requirements, constructed of lower cost materials and utilizing high volume manufacturing methods that will 
make it practical to provide the cryogenic packages offered by the CryoPort Express® System. Other research and development effort has been 
directed toward improvements to the liquid nitrogen retention system to render it more reliable in the general shipping environment and to the 
design of the outer packaging. Alternative phase change materials in place of liquid nitrogen may be used to increase the potential markets these 
shippers can serve such as ambient and 2-8°C markets. Our research and development expenditures during for the fiscal years ended March 31, 
2010 and 2009 were $284,847 and $297,378, respectively.  

11 

 
 
 
 
 
 
 
  
  
Corporate Governance  

Our Board is committed to legal and ethical conduct in fulfilling its responsibilities.  The Board expects all directors, as well as officers 
and employees, to act ethically at all times and to adhere to the policies comprising the Company's Code of Business Conduct and Ethics.  The 
Board  of  Directors  (the  "Board")  of  the  Company  adopted  the  corporate  governance  policies  and  charters.  Copies  of  the  following  corporate 
governance documents are posted on our website, and are available free of charge, at www.cryoport.com : (1) Code of Business Conduct and 
Ethics (2) Charter of the Nominating and Governance Committee of the Board of Directors, (3) Charter of the Audit Committee of the Board of 
Directors, and (4)  Charter of the Compensation Committee of the Board of Directors.  If you would like a printed copy of any of these corporate 
governance  documents,  please  send  your  request  to  CryoPort,  Inc.,  Attention:  Corporate  Secretary,     20382  Barents  Sea  Circle,  Lake  Forest 
CA  92630.  

Human Resources  

As  of  March  31,  2010,  we  had  seven  full-time  employees  and  six  consultants.  Three  of  the  consultants  work  for  us  on  a  full-time 
basis.  Each of our employees has signed a confidentiality agreement and none are covered by a collective bargaining agreement.  We have never 
experienced employment-related work stoppages and consider our employee relations to be good.  

12 

 
 
 
   
 
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
 
   
  
  
ITEM 1A.   RISK FACTORS  

This Annual Report on Form 10-K contains forward-looking information based on our current expectations.  Because our actual results 
may differ materially from  any forward-looking statements made  by or on behalf of CryoPort, this section includes a discussion of  important 
factors that could affect our actual future results, including, but not limited to, our potential product and service revenues, acceptance of our 
products and services, expenses, net income(loss) and earnings(loss) per common share.  

Risks Related to Our Business  

We have incurred significant losses to date and may continue to incur losses.  

We have incurred net losses in each fiscal year since we commenced operations.  The following table represents net losses incurred 

in each of our last two fiscal years:  

Fiscal Year Ended March 31, 2010  
Fiscal Year Ended March 31, 2009  

Net Loss  

  $ 
  $ 

5,651,561   
16,705,151   

As of March 31, 2010, we had an accumulated deficit of $45,943,809.  While we expect to continue to derive revenues from our current 
products  and  services,  in  order  to  achieve  and  sustain  profitable  operations,  we  must  successfully  commercialize  and  launch  our  CryoPort 
Express ® System, significantly expand our market presence and increase revenues.  We may continue to incur losses in the future and may never 
generate  revenues  sufficient  to  become  profitable  or  to  sustain  profitability.   Continuing  losses  may  impair  our  ability  to  raise  the  additional 
capital required to continue and expand our operations.  

Our auditors have expressed doubt about our ability to continue as a going concern.  

The  Report  of  Independent  Registered  Public  Accounting  Firm  to  our  March 31,  2010  consolidated  financial  statements  includes  an 
explanatory paragraph stating that the recurring losses and negative cash flows from operations since inception and our limited working capital 
and  cash  and  cash  equivalent  balance  at  March 31,  2010  raise  substantial  doubt  about  our  ability  to  continue  as  a  going  concern.   The 
consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.  

If we are unable to obtain additional funding, we may have to reduce or discontinue our business operations.  

As  of  June  15,  2010,  we  had  cash  and  cash  equivalents  of  $2,197,878.  We  have  expended  substantial  funds  on  the  research  and 
development of our products and IT systems.  As a result, we have historically experienced negative cash flows from operations and we expect 
to  continue  to  experience  negative  cash  flows  from  operations  in  the  future.   Therefore,  our  ability  to  continue  and  expand  our  operations  is 
highly dependent on the amount of cash and cash equivalents on hand combined with our ability to raise additional capital to fund our future 
operations.  

We  anticipate,  based  on  currently  proposed  plans  and  assumptions  relating  to  our  ability  to  market  and  sell  our  products  (but  not 
including any additional strategic relationships with global couriers), that our cash on hand, together with projected cash flows, will satisfy our 
operational and capital requirements through September 2010.  There are a number of uncertainties associated with our financial projections that 
could reduce or delay our future projected revenues and cash-inflows, including, but not limited to, our ability to complete the commercialization 
and  launch  of  our  CryoPort  Express  ®  System,  launch  our  relationship  with  FedEx,  increase  our  customer  base  and  revenues  and  enter  into 
strategic  relationships  with  additional  global  couriers.   If  our  projected  revenues  and  cash-inflows  are  reduced  or  delayed,  we  may  not  have 
sufficient capital to operate through September 2010 unless we raise more capital.  Additionally, if we are unable to realize satisfactory revenue 
in the near future, we will be required to seek additional financing to continue our operations beyond that period.  We will also require additional 
financing  to  expand  into  other  markets  and  further  develop  and  market  our  products.   We  have  no  current  arrangements  with  respect  to  any 
additional financing.  Consequently, there can be no assurance that any additional financing on commercially reasonable terms, or at all, will be 
available  when  needed.   The  inability  to  obtain  additional  capital  may  reduce  our  ability  to  continue  to  conduct  business  operations.   Any 
additional  equity  financing  may  involve  substantial  dilution  to  our  then  existing  stockholders.   In  addition,  raising  additional  funding  may  be 
complicated  by  certain  provisions  in  the  securities  purchase  agreements  and  related  transaction  documents,  as  amended,  entered  into  in 
connection with our prior convertible debenture financings.  The uncertainties surrounding our future cash inflows have raised substantial doubt 
regarding our ability to continue as a going concern.  

 
 
 
 
 
   
 
 
 
 
 
   
 
 
  
  
  
  
  
  
13 

If we are not successful in establishing strategic relationships with global couriers, we may not be able to successfully increase revenues and 
cashflow which could adversely affect our operations.  

We believe that our near term success is best achieved by establishing strategic relationships with global couriers, such as our recent 
agreement  with  FedEx.   Such  relationships  will  enable  us  to  provide  a  seamless,  end-to-end  shipping  solution  to  customers  and  allow  us  to 
leverage the couriers’ established express, ground and freight infrastructures and penetrate new markets with minimal investment.  Further, we 
expect  that  the  global  couriers  will  utilize  their  sales  forces  to  promote  and  sell  our  frozen  shipping  services.   If  we  are  not  successful  in 
launching  our  relationship  with  FedEx  or  establishing  additional  relationships  with  global  couriers,  our  sales  and  marketing  efforts  will  be 
significantly impacted and anticipated revenue growth will be substantially delayed which could have an adverse affect on our operations.  

Our agreement with FedEx may not result in a significant increase in our revenues or cashflow.  

On January 13, 2010, we entered into an agreement with FedEx pursuant to which we will lease to FedEx such number of our cryogenic 
shippers that FedEx shall, from time to time, order for its customers.  FedEx has the right to and shall, on a non-exclusive basis, promote, market 
and sell transportation of our shippers and our related value-added goods and services, such as our data logger, web portal and planned CryoPort 
Express  Smart  Pak  System.   Because  our  agreement  with  FedEx  does  not  contain  any  requirement  that  FedEx  lease  a  minimum  number  of 
shippers from us during the term of the agreement, we may not experience a significant increase in our revenues or cashflows as a result of this 
agreement.  Further,  while  we  are  working  with  FedEx  to  implement  and  launch  our  relationship,  we  may  experience  delays  in  such 
implementation which could adversely affect our revenues.  

Current  economic  conditions  and  capital  markets  are  in  a  period  of  disruption  and  instability  which  could  adversely  affect  our  ability  to 
access the capital markets, and thus adversely affect our business and liquidity.  

The current economic conditions and financial crisis have had, and will continue to have, a negative impact on our ability to access the 
capital markets, and thus have a negative impact on our business and liquidity.  The shortage of liquidity and credit combined with substantial 
losses  in  worldwide  equity  markets  could  lead  to  an  extended  worldwide  recession.   We  may  face  significant  challenges  if  conditions  in  the 
capital markets do not improve.  Our ability to access the capital markets has been and continues to be severely restricted at a time when we need 
to access such markets, which could have a negative impact on our business plans, including the commercialization and launch of our CryoPort 
Express ® System and other research and development activities.  Even if we are able to raise capital, it may not be at a price or on terms that are 
favorable to us.  We cannot predict the occurrence of future financial disruptions or how long the current market conditions may continue.  

The sale of substantial shares of our common stock may depress our stock price.  

As  of  March  31,  2010,  there  were  8,136,619  shares  of  our  common  stock  outstanding.  Substantially  all  of  these  shares  of  common 
stock are eligible for trading in the public market.  The market price of our common stock may decline if our stockholders sell a large number of 
shares of our common stock in the public market, or the market perceives that such sales may occur.  

14 

 
 
 
 
 
 
 
   
 
 
 
  
  
We  could  also  issue  up  to  8,276,519  additional  shares  of  our  common  stock  including  shares  to  be  issued  upon  conversion  of  the 
outstanding  balance  of  our  convertible  debentures  and  upon  the  exercise  of  outstanding  warrants  and  options  or  reserved  for  future  issuance 
under our stock incentive plans, as further described in the following table:  

Common stock issuable upon conversion of the outstanding balance 

of our convertible debentures  

Common stock issuable upon exercise of outstanding warrants  
Common stock issuable upon exercise of  outstanding options 

or reserved for future incentive awards under our stock incentive 
plans  

Total  

Number of Shares of Common Stock  
Issuable or Reserved For Issuance  

1,076,856  
5,540,532  

1,659,131  

8,276,519  

Of  the  total  options  and  warrants  outstanding  as  of  March  31,  2010,  options  and  warrants  exercisable  for  an  aggregate  of  38,782  shares  of 
common stock would be considered dilutive to the value of our stockholders’ interest in CryoPort because we would receive upon exercise of 
such options and warrants an amount per share that is less than the market price of our common stock on March 31, 2010.  

We  will  have  difficulty  increasing  our  revenues  if  we  experience  delays,  difficulties  or  unanticipated  costs  in  establishing  the  sales, 
distribution and marketing capabilities necessary to successfully commercialize our products.  

We are continuing to develop sales, distribution and marketing capabilities in the Americas, Europe and Asia.  It will be expensive and 
time-consuming for us to develop a global marketing and sales network.  Moreover, we may choose, or find it necessary, to enter into additional 
strategic collaborations to sell, market and distribute our products.  We may not be able to provide adequate incentive to our sales force or to 
establish and maintain favorable distribution and marketing collaborations with other companies to promote our products.  In addition, any third 
party with whom we have established a marketing and distribution relationship may not devote sufficient time to the marketing and sales of our 
products thereby exposing us to potential expenses in exiting such distribution agreements.  We, and any of our third party collaborators, must 
also market our products in compliance with federal, state, local and international laws relating to the provision of incentives and inducements.  
Violation of these laws can result in substantial penalties.  Therefore, if we are unable to successfully motivate and expand our marketing and 
sales force and further develop our sales and marketing capabilities, or if our distributors fail to promote our products, we will have difficulty 
increasing our sales.  

Our ability to grow and compete in our industry will be hampered if we are unable to retain the continued service of our key professionals or 
to identify, hire and retain additional qualified professionals.  

A critical factor to our business is our ability to attract and retain qualified professionals including key employees and consultants.  We 
are continually at risk of losing current professionals or being unable to hire additional professionals as needed.  If we are unable to attract new 
qualified employees, our  ability  to grow  will be adversely affected.  If we are  unable to retain current employees  or strategic consultants, our 
financial condition and ability to maintain operations may be adversely affected.  

15 

 
 
   
 
 
 
   
 
 
 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
We are dependent on new products and services, the lack of which would harm our competitive position.  

Our future revenue stream depends to a large degree on our ability to bring new products and services to market on a timely basis.  We 
must continue to make significant investments in research and development in order to continue to develop new products and services, enhance 
existing products and services, and achieve market acceptance of such products and services.  We may incur problems in the future in innovating 
and introducing new products and services.  Our development stage products and services may not be successfully completed or, if developed, 
may not achieve significant customer acceptance.  If we are unable to successfully define, develop and introduce new, competitive products and 
services  and  enhance  existing  products  and  services,  our  future  results  of  operations  would  be  adversely  affected.   Development  and 
manufacturing  schedules  for  technology  products  and  services  are  difficult  to  predict,  and  we  might  not  achieve  timely  initial  customer 
shipments of new products or launch of services.   The timely availability of these products and services and their acceptance by customers are 
important to our future success.  A delay in new or enhanced product or service introductions could have a significant impact on our results of 
operations.  

Because  of  these  risks,  our  research  and  development  efforts  may  not  result  in  any  commercially  viable  products  or  services.   If 
significant  portions  of  these  development  efforts  are  not  successfully  completed,  or  any  new  or  enhanced  products  or  services  are  not 
commercially successful, our business, financial condition and results of operations may be materially harmed.  

If we successfully develop products and/or services, but those products and/or services do not achieve and maintain market acceptance, our 
business will not be profitable.  

The degree of acceptance of our CryoPort Express  ® Shipper and/or CryoPort Express® System, or any future product or services, by 
our current target markets, and any other markets to which we attempt to sell our products and services, and our profitability and growth will 
depend on a number of factors including, among others:  

•  
•  
•  
•  
•  

   our shipper’s ability to perform and preserve the integrity of the materials shipped;  
   relative convenience and ease of use of our shipper and/or web portal;  
   availability of alternative products;  
   pricing and cost effectiveness; and  
   effectiveness of our or our collaborators’ sales and marketing strategy.  

If any products or services we may develop do not achieve market acceptance, then we may not generate sufficient revenue to achieve 

or maintain profitability.  

In addition, even if our products and services achieve market acceptance, we may not be able to maintain that market acceptance over 
time  if  new  products  or  services  are  introduced  that  are  more  favorably  received  than  our  products  and  services,  are  more  cost  effective,  or 
render our products obsolete.  

Our success depends, in part, on our ability to obtain patent protection for our products and business model, preserve our trade secrets, and 
operate without infringing the proprietary rights of others.  

Our policy is to seek to protect our proprietary position by, among other methods, filing United States patent applications related to our 
technology,  inventions  and  improvements  that  are  important  to  the  development  of  our  business.   We  have  three  issued  U.S. patents  and  one 
recently  filed  provisional  patent  application,  all  relating  to  various  aspects  of  our  products  and  services.   Our  patents  or  provisional  patent 
application  may be  challenged, invalidated or circumvented  in  the  future or  the  rights granted may  not  provide a competitive advantage.  We 
intend  to  vigorously  protect  and  defend  our  intellectual  property.   Costly  and  time-consuming  litigation  brought  by  us  may  be  necessary  to 
enforce our patents and to protect our trade secrets and know-how, or to determine the enforceability, scope and validity of the proprietary rights 
of others.  

We also rely upon trade secrets, technical know-how and continuing technological innovation to develop and maintain our competitive 
position.   In  the  past  our  employees,  consultants,  advisors  and  suppliers  have  not  always  executed  confidentiality  agreements  and  invention 
assignment and work for hire agreements in connection with their employment, consulting, or advisory relationships.  Consequently, we may not 
have adequate remedies available to us to protect our intellectual property should one of these parties attempt to use our trade secrets or refuse to 
assign any rights he or she may have in any intellectual property he or she developed for us.  Additionally, our competitors may independently 
develop substantially equivalent proprietary information and techniques or otherwise gain access to our proprietary technology, or we may not 
be able to meaningfully protect our rights in unpatented proprietary technology.  

 
 
 
 
 
 
   
 
 
   
 
 
 
  
  
    
    
    
    
  
16 

We  cannot  assure  you  that  our  current  and  potential  competitors  and  other  third  parties  have  not  filed  (or  in  the  future  will  not  file) 
patent  applications  for (or  have not  received  or  in the  future will  not  receive)  patents  or obtain  additional  proprietary  rights that will prevent, 
limit or interfere with our ability to make, use or sell our products either in the United States or internationally.  In the event we are required to 
license patents  issued  to third  parties,  such  licenses  may  not  be  available  or,  if  available, may  not  be available  on  terms  acceptable  to  us.   In 
addition, we cannot assure you that we would be successful in any attempt to redesign our products or processes to avoid infringement or that 
any  such  redesign  could  be  accomplished  in  a  cost-effective  manner.   Accordingly,  an  adverse  determination  in  a  judicial  or  administrative 
proceeding or failure to obtain necessary licenses could prevent us from manufacturing and selling our products or offering our services, which 
would harm our business.  

We are not aware of any third party that is infringing any of our patents or trademarks nor do we believe that we are infringing on the 

patents or trademarks of any other person or organization.  

Our products may contain errors or defects, which could result in damage to our reputation, lost revenues, diverted development resources 
and increased service costs and litigation.  

Our  products  must  meet  stringent  requirements  and  we  must  develop  our  products  quickly  to  keep  pace  with  the  rapidly  changing 
market.  Products and services as sophisticated as ours could contain undetected errors or defects, especially when first introduced or when new 
models or versions are released.  In general, our products may not be free from errors or defects after commercial shipments have begun, which 
could  result  in  damage  to  our  reputation,  lost  revenues,  diverted  development  resources,  increased  customer  service  and  support  costs,  and 
litigation.  The costs incurred in correcting any product errors or defects may be substantial and could adversely affect our business, results of 
operations and financial condition.  

If we experience manufacturing delays or interruptions in production, then we may experience customer dissatisfaction and our reputation 
could suffer.  

If  we  fail  to  produce  enough  shippers  at  our  own  manufacturing  facility  or  at  a  third  party  manufacturing  facility,  or  if  we  fail  to 
complete our shipper recycling processes as planned, we may be unable to deliver shippers to our customers on a timely basis, which could lead 
to customer dissatisfaction and could harm our reputation and ability to compete.  We currently acquire various component parts for our shippers 
from  various  independent  manufacturers  in  the  United  States.   We  would  likely  experience  significant  delays  or  cessation  in  producing  our 
shippers if a labor strike, natural disaster or other supply disruption were to occur at any of our main suppliers.  If we are unable to procure a 
component  from  one  of  our  manufacturers,  we  may  be  required  to  enter  into  arrangements  with  one  or  more  alternative  manufacturing 
companies which may cause delays in producing our shippers.  In addition, because we depend on third party manufacturers, our profit margins 
may be lower, which will make it more difficult for us to achieve profitability.  To date, we have not experienced any material delay that has 
adversely  impacted  our  operations.   As  our  business  develops  and  the  quantity  of  production  increases,  it  becomes  more  likely  that  such 
problems could arise.  

Because we rely on a limited number of suppliers, we may experience difficulty in meeting our customers’ demands for our products in a 
timely manner or within budget.  

We  currently  purchase  key  components  of  our  products  from  a  variety  of  outside  sources.   Some  of  these  components  may  only  be 
available  to  us  through  a  few  sources,  however,  management  has  identified  alternative  materials  and  suppliers  should  the  need  arise.   We 
generally do not have long-term agreements with any of our suppliers.  

Consequently,  in  the  event  that  our  suppliers  delay  or  interrupt  the  supply  of  components  for  any  reason,  we  could  potentially 
experience higher product costs and longer lead times in order fulfillment.  Suppliers that we materially rely upon include Spaulding Composites 
Company and Lydall Thermal Acoustical Sales.  

17 

 
 
 
 
 
 
 
 
 
 
 
 
  
  
Our CryoPort Express ® Portal may be subject to intentional disruption that could adversely impact our reputation and future sales.  

We have  implemented  our CryoPort Express  ®  Portal which is  used  by  our customers and  business  partners  to  automate the  entry  of 
orders, prepare customs documentation and facilitate status and location monitoring of shipped orders while in transit.  Although we believe we 
have  sufficient  controls  in  place  to  prevent  intentional  disruptions,  we  could  be  a  target  of  attacks  specifically  designed  to  impede  the 
performance of the CryoPort Express ® Portal.  Similarly, experienced computer programmers may attempt to penetrate our CryoPort Express ® 
Portal in an effort to search for and misappropriate proprietary or confidential information or cause interruptions of our services.  Because the 
techniques  used by  such  computer  programmers to  access  or  sabotage  networks  change  frequently  and  may  not be  recognized  until  launched 
against a target, we may be unable to anticipate these techniques.  Our activities could be adversely affected and our reputation, brand and future 
sales harmed if these intentionally disruptive efforts are successful.  

Our products and services may expose us to liability in excess of our current insurance coverage.  

Our products and services involve significant risks of liability, which may substantially exceed the revenues we derive from them.  We 

cannot predict the magnitude of these potential liabilities.  

We  currently  maintain  general  liability  insurance,  with  coverage  in  the  amount  of  $1  million  per  occurrence,  subject  to  a  $2 million 
annual limitation, and product liability insurance with a $1 million annual coverage limitation.  Claims may be made against us that exceed these 
limits.  

Our liability policy is an “occurrence” based policy.  Thus, our policy is complete when we purchased it and following cancellation of 
the policy it continues to provide coverage for future claims based on conduct that took place during the policy term.  However, our insurance 
may not protect us against liability because our policies typically have various exceptions to the claims covered and also require us to assume 
some costs of the claim even though a portion of the claim may be covered.  In addition, if we expand into new markets, we may not be aware of 
the need for, or be able to obtain insurance coverage for such activities or, if insurance is obtained, the dollar amount of any liabilities incurred 
could  exceed  our  insurance  coverage.   A  partially  or  completely  uninsured  claim,  if  successful  and  of  significant  magnitude,  could  have  a 
material adverse effect on our business, financial condition and results of operations.  

Complying with certain regulations that apply to shipments using our products can limit our activities and increase our cost of operations.  

Shipments  using  our  products  and  services  are  subject  to  various  regulations  in  the  countries  in  which  we  operate.   For  example, 
shipments  using  our  products  may  be  required  to  comply  with  the  shipping  requirements  promulgated  by  the  Centers  for  Disease  Control 
(“CDC”), the Occupational Safety and Health Organization (“OSHA”), the Department of Transportation (“DOT”) as well as rules established 
by  the  International  Air  Transportation  Association  (“IATA”)  and  the  International  Civil  Aviation  Organization  (“ICAO”).   Additionally,  our 
data logger may be subject to regulation and certification by the Food and Drug Administration (“FDA”), Federal Communications Commission 
(“FCC”), and Federal Aviation Administration (“FAA”).  We will need to ensure that our products and services comply with relevant rules and 
regulations to make our products and services marketable, and in some cases compliance is difficult to determine.  Significant changes in such 
regulations could require costly changes to our products and services or prevent use of our shippers for an extended period of time while we seek 
to comply with changed regulations.  If we are unable to comply with any of these rule or regulations or fail to obtain any required approvals, 
our  ability  to  market  our  products  and  services  may  be  adversely  affected.   In  addition,  even  if  we  are  able  to  comply  with  these  rules  and 
regulations, compliance can result in increased costs.  In either event, our financial results and condition may be adversely affected.  We depend 
on  our  business  partners  and  unrelated  and  frequently  unknown  third  party  agents  in  foreign  countries  to  act  on  our  behalf  to  complete  the 
importation process and to make delivery of our shippers to the final user.  The failure of these third parties to perform their duties could result in 
damage to the contents of the shipper resulting in customer dissatisfaction or liability to us, even if we are not at fault.  

18 

 
 
 
 
 
 
 
   
 
 
 
  
  
If we cannot compete effectively, we will lose business.  

Our products, services and solutions are positioned to be competitive in the cold-chain shipping market.  While there are technological 
and marketing barriers to entry, we cannot guarantee that the barriers we are capable of producing will be sufficient to defend the market share 
we wish to gain against current and future competitors.  The principal competitive factors in this market include:  

•  
•  
•  
•  
•  
•  
•  
•  

   acceptance of our business model and a per use consolidated fee structure;  
   ongoing development of enhanced technical features and benefits;  
   reductions in the manufacturing cost of competitors’ products;  
   the ability to maintain and expand distribution channels;  
   brand name;  
   the ability to deliver our products to our customers when requested;  
   the timing of introductions of new products and services; and  
   financial resources.  

Current  and  prospective  competitors  have  substantially  greater  resources,  more  customers,  longer  operating  histories,  greater  name 
recognition and more established relationships in the industry.  As a result, these competitors may be able to develop and expand their networks 
and  product  offerings  more  quickly,  devote  greater  resources  to  the  marketing  and  sale  of  their  products  and  adopt  more  aggressive  pricing 
policies.  In addition, these competitors have entered and will likely continue to enter into business relationships to provide additional products 
competitive to those we provide or plan to provide.  

We may not be able to compete with our competitors in the industry because many of them have greater resources than we do.  

We  expect  to  continue  to  experience  significant  and  increasing  levels  of  competition  in  the  future.   In  addition,  there  may  be  other 
companies which are currently developing competitive products and services or which may in the future develop technologies and products that 
are comparable, superior or less costly than our own.  For example, some cryogenic equipment manufacturers with greater resources currently 
have  solutions  for  storing  and  transporting  cryogenic  liquid  and  gasses  and  may  develop  storage  solutions  that  compete  with  our  products.  
Additionally,  some  specialty  couriers  with  greater  resources  currently  provide  dry  ice  transportation  and  may  develop  other  products  in  the 
future, both  of  which  compete with our  products.  A competitor that has greater  resources  than us  may be able to bring its product to market 
faster than we can and offer its product at a lower price than us to establish market share.  We may not be able to successfully compete with a 
competitor that has greater resources and such competition may adversely affect our business.  

Risks Relating to Our Current Financing Arrangements  

Our outstanding convertible debentures impose certain restrictions on how we conduct our business.  In addition, all of our assets, including 
our intellectual property, are pledged to secure this indebtedness.  If we fail to meet our obligations to the debenture holders, our payment 
obligations may be accelerated and the collateral securing the indebtedness may be sold to satisfy these obligations.  

We issued convertible  debentures in October 2007 (the  “October  2007 Debentures”)  and in  May 2008  (the  “May 2008  Debentures,”
and  together  with  the  October  2007  Debentures,  the  “Debentures”).     The  Debentures were  issued to  four  institutional  investors  and  have  an 
outstanding principal balance of $3,230,568 as of March 31, 2010.  In addition, in October 2007 and May 2008, we issued to these institutional 
investors  warrants  to  purchase,  as  of  March  31,  2010,  an  aggregate  of  3,055,097  shares  of  our  common  stock  (without  regard  to  beneficial 
ownership  limitations  contained  in  the  transaction  documents  and  certain  anti-dilution  provisions).   As  collateral  to  secure  our  repayment 
obligations to the holders of the Debentures we have granted such holders a first priority security interest in generally all of our assets, including 
our intellectual property.  

19 

 
 
 
   
 
 
 
 
 
 
 
 
  
  
    
    
    
    
    
    
    
  
The  Debentures,  warrant  agreements  and  related  transactional  documents  (including  subsequent  amendments)  contain  various 

covenants that presently restrict our operating flexibility.  Pursuant to the foregoing documents, we may not, among other things:  

•  

   Other than the reverse stock split we effected on February 5, 2010, which the holder of our Debentures consented to, effect future 

reverse stock splits of our outstanding common stock;  

•  

   incur  additional  indebtedness,  except  for  certain  permitted  indebtedness. Permitted  indebtedness  is  defined  to  include  lease 
obligations and purchase money indebtedness of up to an aggregate of $200,000 and indebtedness that is expressly subordinated to 
the Debentures and matures following the maturity date of the Debentures;  

•  

   incur additional liens on any of our assets except for certain permitted liens including but not limited liens for taxes, assessments 

and government charges not yet due and liens incurred in connection with permitted indebtedness;  

•  
•  

•  
•  

   pay cash dividends;  
   redeem any outstanding shares of our common stock or any outstanding options or warrants to purchase shares of our common stock 
except  in  connection  with  a  the  repurchase  of  stock  from  former  directors  and  officers  provided  such  repurchases  do  not  exceed 
$100,000 during the term of the Debentures;  

   enter into transactions with affiliates other than on arms-length terms; and  
   make any revisions to the terms of existing contractual agreements for the Related Party Notes Payable and the Line of Credit (as 

each is referred to in our Form 10-Q for the period ended June 30, 2009).  

These provisions could have important consequences for us, including, but not limited to, (i) making it more difficult for us to obtain 
additional debt financing, or obtain new debt financing on terms favorable to us, because a new lender will have to be willing to be subordinate 
to the debenture holders, (ii) causing us to use a portion of our available cash for debt repayment and service rather than other perceived needs, 
and/or (iii) impacting our ability to take advantage of significant, perceived business opportunities.  Our failure to timely repay our obligations 
under the Debentures, which require monthly principal payments of $200,000 commencing March 1, 2011 and which mature on August 1, 2012, 
or meet the covenants set forth in the Debentures and related transaction documents could give rise to a default under the Debentures or such 
transaction documents.  In the event of an uncured default, all amounts owed to the holders may be declared immediately due and payable and 
the debenture holders will have the right to enforce their security interest in the assets securing the Debentures.  In such event, the Debenture 
holders could take possession of any or all of our assets in which they hold a security interest, and dispose of those assets to the extent necessary 
to pay off our debts, which would materially harm our business.  

Certain of our existing stockholders own and have the right to acquire a substantial number of shares of common stock.  

As of March 31, 2010, our directors, executive officers and debenture holders beneficially owned 4,266,712 shares (without regard to 
beneficial ownership limitations contained in certain warrants) of common stock assuming their exercise of all outstanding warrants, options and 
conversion of all convertible debt; or approximately 34.4% of our outstanding common stock.  Of these shares of common stock, 2,059,680, or 
approximately  19.1%  of  our  outstanding  common  stock,  will  be  beneficially  owned  by  Enable  Growth  Partners  LP  (and  affiliated  funds), 
and 2,072,273  shares,  or  approximately 19.4%  of  our  outstanding  common  stock,  will  be  owned  by  BridgePointe  Master  Fund,  Ltd.  (each 
calculated without regard to the shares of common stock that may be acquired by the other upon the exercise of its warrants); provided, however, 
there are provisions in their warrant agreements that prohibit exercise of warrants to the extent that their respective beneficial ownership would 
exceed 4.99% as a result of such conversion or exercise (which limitation may be waived and increased to 9.99% upon not less than 61 days 
prior notice).  As such, the concentration of beneficial ownership of our stock may have the effect of delaying or preventing a change in control 
of CryoPort and may adversely affect the voting or other rights of other holders of our common stock.  

20 

 
 
   
 
 
 
 
 
  
  
    
    
    
    
    
    
  
Our stock and warrant price is and will continue to be volatile.  

The market price of our common stock has been and, along with the warrants is likely to be, highly volatile and could fluctuate widely 

in price in response to various factors, many of which are beyond our control, including, but not limited to:  

•  
•  
•  
•  
•  
•  
•  
•  
•  
•  

   technological innovations or new products and services by us or our competitors;  
   additions or departures of key personnel;  
   sales of our common stock;  
   our ability to integrate operations, technology, products and services;  
   our ability to execute our business plan;  
   operating results below expectations;  
   loss of any strategic relationship;  
   industry developments;  
   economic and other external factors; and  
   period-to-period fluctuations in our financial results.  

You may consider any one of these factors to be material.  The price of our common stock and warrants may fluctuate widely as a result 
of  any  of  the  above  listed  factors.   In  addition,  the  securities  markets  have  from  time  to  time  experienced  significant  price  and  volume 
fluctuations  that  are  unrelated  to  the  operating  performance  of  particular  companies.   These  market  fluctuations  may  also  materially  and 
adversely affect the market price of our common stock and warrants.  

If equity research analysts do not publish research or reports about our business or if they issue unfavorable commentary or downgrade our 
common stock and warrants, the price of our common stock and warrants could decline.  

The trading market for our common stock and warrants relies in part on the research and reports that equity research analysts publish 
about us and our business.  We do not control these analysts.  The price of our common stock and warrants could decline if one or more equity 
analyst downgrades our stock or if analysts issue other unfavorable commentary or cease publishing reports about us or our business.  

We  have not paid dividends on our common stock in the  past and do  not expect to pay dividends in the foreseeable future. Any return on 
investment may be limited to the value of our common stock.  

We have never paid cash dividends on our common stock and do not anticipate paying cash dividends in the foreseeable future.  The 
payment of dividends on our common stock will depend on our earnings, financial condition and other business and economic factors affecting 
us at such time as the Board of Directors may consider the payment of any such dividends.  In addition, we may not pay any dividends without 
obtaining  the  prior  consent of the  holders of our Debentures.  If  we do not pay  dividends,  our common stock may be  less valuable  because a 
return on your investment will only occur if the price of our common stock appreciates.  

As a result of our recent 10-to-1 reverse stock split, the liquidity of our common stock and market capitalization could be adversely affected.  

On  February  5,  2010,  we  effected  a  10-to-1  reverse  stock  split.  A  reverse  stock  split  is  often  viewed  negatively  by  the  market  and, 
consequently,  can  lead  to  a  decrease  in  our  overall  market  capitalization.   In  addition,  because  the  reverse  split  will  significantly  reduce  the 
number of shares of our common stock that are outstanding, the liquidity of our common stock could be adversely affected and you may find it 
more difficult to purchase or sell shares of our common stock.  

21 

 
 
 
 
 
 
 
 
 
 
   
 
  
    
    
    
    
    
    
    
    
    
    
  
We  may  need  additional  capital,  and  the  sale  of  additional  shares  of  common  stock  or  other  equity  securities  could  result  in  additional 
dilution to our stockholders.  

We  believe  that  our  current  cash  and  cash  equivalents  and  anticipated  cash  flow  from  operations  will  be  sufficient  to  meet  our 
anticipated  cash  needs  for  a  period  of  6  months.   We  may,  however,  require  additional  cash  resources  due  to  changed  business  conditions  or 
other future developments, including any investments or acquisitions we may decide to pursue.  If our resources are insufficient to satisfy our 
cash requirements, we may seek to sell additional equity or debt securities or obtain a credit facility.  The sale of additional equity securities, or 
debt securities convertible into equity securities, could result in additional dilution to our stockholders.  The incurrence of indebtedness would 
result in increased debt service obligations and could result in operating and financing covenants that would restrict our operations.  

Provisions  in  our  bylaws  and  Nevada  law  might  discourage,  delay  or  prevent  a  change  of  control  of  our  company  or  changes  in  our 
management and, as a result, may depress the trading price of our common stock.  

Provisions  of  our  bylaws  and  Nevada  law  may  discourage,  delay  or  prevent  a  merger,  acquisition  or  other  change  in  control  that 
stockholders may consider favorable, including transactions in which you might otherwise receive a premium for your shares of our common 
stock.  The relevant bylaw provisions may also prevent or frustrate attempts by our stockholders to replace or remove our management.  These 
provisions include advance notice requirements for stockholder proposals and nominations, and the ability of our Board of Directors to make, 
alter or repeal our bylaws.  

Absent approval of our Board of Directors, our bylaws may only be amended or repealed by the affirmative vote of the holders of at 

least a majority of our outstanding shares of capital stock entitled to vote.  

In addition, Section 78.438 of the Nevada Revised Statutes prohibits a publicly-held Nevada corporation from engaging in a business 
combination with an interested stockholder (generally defined as a person which together with its affiliates owns, or within the last three years 
has  owned,  10%  of  our  voting  stock,  for  a  period  of  three  years  after  the  date  of  the  transaction  in  which  the  person  became  an  interested 
stockholder) unless the business combination is approved in a prescribed manner.  

The  existence  of  the  foregoing  provisions  and  other  potential  anti-takeover  measures  could  limit  the  price  that  investors  might  be 
willing  to  pay in  the future  for  shares  of  our common  stock.   They  could  also deter  potential  acquirers  of  our company, thereby  reducing the 
likelihood that you could receive a premium for your common stock in an acquisition.  

Even though we are not incorporated in California, we may become subject to a number of provisions of the California General Corporation 
Law.  

Section  2115(b)  of  the  California  Corporations  Code  imposes  certain  requirements  of  California  corporate  law  on  corporations 
organized  outside  California  that,  in  general,  are  doing  more  than  50%  of  their  business  in  California  and  have  more  than  50%  of  their 
outstanding voting securities held of record by persons residing in California.  While we are not currently subject to Section 2115(b), we may 
become subject to it in the future.  

The following summarizes some of the principal differences which would apply if we become subject to Section 2115(b).  

Under  both  Nevada  and  California  law,  cumulative  voting  for  the  election  of  directors  is  permitted.  However,  under  Nevada  law 
cumulative voting must be expressly authorized in the Articles of Incorporation and our Amended and Restated Articles of Incorporation do not 
authorize  cumulative  voting.  If  we  become  subject  to  Section  2115(b),  we  may  be  required  to  permit  cumulative  voting  if  any  stockholder 
properly requests to cumulate his or her votes.  

Under Nevada law, directors may be removed by the stockholders only by the vote of two-thirds of the voting power of the issued and 
outstanding stock entitled to vote.  However, California law permits the removal of directors by the vote of only a majority of the outstanding 
shares entitled to vote.  If we become subject to Section 2115(b), the removal of a director may be accomplished by a majority vote, rather than a 
vote of two-thirds, of the stockholders entitled to vote.  

22 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
  
Under California law,  the  corporation  must  take  certain  steps to  be allowed to  provide for greater  indemnification  of  its officers  and 
directors than is provided in the California Corporation Code.  If we become subject to Section 2115(b), our ability to indemnify our officers and 
directors may be limited by California law.  

Nevada law permits distributions to stockholders as long as, after the distribution, (i) the corporation would be able to pay its debts as 
they become due and (ii) the corporation’s total assets are at least equal to its liabilities and preferential dissolution obligations. Under California 
law,  distributions  may  be  made  to  stockholders  as  long  as  the  corporation  would  be  able  to  pay  its  debts  as  they  mature  and  either  (i)  the 
corporation’s  retained  earnings  equals  or  exceeds  the  amount  of  the  proposed  distributions,  or  (ii)  after  the  distributions,  the  corporation’s 
tangible assets are at least 125% of its liabilities and the corporation’s current assets are at least equal to its current liabilities (or, 125% of its 
current liabilities if the corporation’s average operating income for the two most recently completed fiscal years was less than the average of the 
interest  expense  of  the  corporation  for  those  fiscal  years).  If  we  become  subject  to  Section  2115(b),  we  will  have  to  satisfy  more  stringent 
financial  requirements to be  able to pay dividends  to  our  stockholders.  Additionally, stockholders  may  be  liable  to  the corporation  if  we  pay 
dividends in violation of California law.  

California law permits a corporation to provide “supermajority vote” provisions in its Articles of Incorporation, which would require 
specific actions to obtain greater than a majority of the votes, but not more than 66 2/3 percent.  Nevada law does not permit supermajority vote 
provisions.  If we become subject to Section 2115(b), it is possible that our stockholders would vote to amend our Articles of Incorporation and 
require a supermajority vote for us to take specific actions.  

Under  California  law,  in  a  disposition  of  substantially  of  all  the  corporation’s  assets,  if  the  acquiring  party  is  in  control  of  or  under 
common control with the disposing corporation, the principal terms of the sale must be approved by 90 percent of the stockholders.  Although 
Nevada  law  does  contain  certain  rules  governing  interested  stockholder  business  combinations,  it  does  not  require  similar  stockholder 
approval.  If we become subject to Section 2115(b), we may have to obtain the vote of a greater percentage of the stockholders to approve a sale 
of our assets to a party that is in control of, or under common control with, us.  

California  law  places  certain  additional  approval  rights  in  connection  with  a  merger  if  all  of  the  shares  of  each  class  or  series  of  a 
corporation are not treated equally or if the surviving or parent party to a merger represents more than 50 percent of the voting power of the other 
corporation prior to the merger.  Nevada law does not require such approval.  If we become subject to Section 2115(b), we may have to obtain a 
the vote of a greater percentage of the stockholders to approve a merger that treats shares of a class or series differently or where a surviving or 
parent party to the merger represents more than 50% of the voting power of the other corporation prior to the merger.  

California law requires the vote of each class to approve a reorganization or a conversion of a corporation into another entity.  Nevada 
law does not require a separate vote for each class. If we become subject to Section 2115(b), we may have to obtain the approval of each class if 
we desire to reorganize or convert into another type of entity.  

California  law  provides  greater  dissenters’  rights  to  stockholders  than  Nevada  law.  If  we  become  subject  to  Section  2115(b),  more 

stockholders may be entitled to dissenters’ rights, which may limit our ability to merge with another entity or reorganize.  

Our stock is deemed to be penny stock.  

Our stock is currently traded on the OTC Bulletin Board and is subject to the “penny stock rules” adopted pursuant to Section 15(g) of 
the  Securities  Exchange  Act  of  1934,  as  amended  (the  “Exchange  Act”).   The  penny  stock  rules  apply  to  companies  not  listed  on  a  national 
exchange whose common stock trades at less than $5.00 per share or which have tangible net worth of less than $5,000,000 ($2,000,000 if the 
company has been operating for three or more years).  Such rules require, among other things, that brokers who trade “penny stock” to persons 
other  than  “established  customers”  complete  certain  documentation,  make  suitability  inquiries  of  investors  and  provide  investors  with  certain 
information concerning trading in the security, including a risk disclosure document and quote information under certain circumstances.  Penny 
stocks sold in violation of the applicable rules may entitle the buyer of the stock to rescind the sale and receive a full refund from the broker.  

23 

 
 
 
 
 
   
 
 
 
 
 
 
  
  
Many brokers have decided not to trade “penny stock” because of the requirements of the penny stock rules and, as a result, the number 
of broker-dealers willing to act as market makers in such securities is limited. In the event that we remain subject to the “penny stock rules” for 
any significant period, there may develop an adverse impact on the market, if any, for our securities.  Because our securities are subject to the 
“penny stock rules,” investors will find it more difficult to dispose of our securities.  Further, for companies whose securities are traded in the 
OTC Bulletin Board, it is more difficult: (i) to obtain accurate quotations, (ii) to obtain coverage for significant news events because major wire 
services, such as the Dow Jones News Service, generally do not publish press releases about such companies, and (iii) to obtain needed capital.  

If we fail to maintain effective internal controls over financial reporting, the price of our common stock may be adversely affected.  

Our  internal  controls  over  financial  reporting  may  have  weaknesses  and  conditions  that  could  require  correction  or  remediation,  the 
disclosure  of  which  may  have  an  adverse  impact  on  the  price  of  our  common  stock.   We  are  required  to  establish  and  maintain  appropriate 
internal controls over financial reporting.  Failure to establish those controls (or any failure of those controls once established) could adversely 
impact  our  public  disclosures  regarding  our  business,  financial  condition  or  results  of  operations.   In  addition,  management’s  assessment  of 
internal controls over financial reporting may identify weaknesses and conditions that need to be addressed in our internal controls over financial 
reporting or other matters that may raise concerns for investors.  Any actual or perceived weaknesses and conditions that need to be addressed in 
our  internal  control  over  financial  reporting,  disclosure  of  management’s  assessment  of  our  internal  controls  over  financial  reporting,  or 
disclosure of our independent registered public accounting firm’s attestation to the effectiveness of our internal controls over financial reporting, 
when required, may have an adverse impact on the price of our common stock.  

                  Standards for compliance with Section 404 of the Sarbanes-Oxley Act of 2002 are uncertain, and if we fail to comply in a timely 
manner, our business could be harmed and our stock price could decline.  

Rules  adopted  by  the  SEC  pursuant  to  Section 404  of  the  Sarbanes-Oxley  Act  of  2002  require  an  annual  assessment  of  our  internal 
controls  over  financial  reporting,  and  attestation  of  our  assessment  by  our  independent  registered  public  accounting  firm.   The  standards  that 
must  be  met  for  management  to  assess  the  internal  controls  over  financial  reporting  as  effective  are  evolving  and  complex,  and  require 
significant documentation, testing, and possible remediation to meet the detailed standards.  We expect to continue to incur significant expenses 
and to devote resources to continued Section 404 compliance during the remainder of fiscal 2011 and on an ongoing basis.  It is difficult for us to 
predict  how  long  it  will  take  or  how  costly  it  will  be  to  complete  the  assessment  of  the  effectiveness  of  our  internal  controls  over  financial 
reporting to the satisfaction of our independent registered public accounting firm for each year, and to remediate any deficiencies in our internal 
controls  over  financial  reporting.   As  a  result,  we  may  not  be  able  to  complete  the  assessment  and  remediation  process  on  a  timely  basis. In 
addition,  the  attestation  process  by  our  independent  registered  public  accounting  firm  will  be  new  for  fiscal  2011  and  we  may  encounter 
problems  or  delays  in  completing  the  implementation  of  any  requested  improvements  and  receiving  an  attestation  of  our  assessment  by  our 
independent registered public accounting firm.  In the event that our Chief Executive Officer, Chief Financial Officer or independent registered 
public accounting firm determines that our internal controls over financial reporting are not effective as defined under Section 404, we cannot 
predict how regulators will react or how the market price of our common stock will be affected; however, we believe that  there  is a risk that 
investor confidence and share value may be negatively impacted.  

24 

 
 
 
 
 
 
 
 
  
  
If we fail to remain current in our reporting requirements, our securities could be removed from the OTC Bulletin Board, which would limit 
the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in the secondary market.  

Companies trading on the OTC Bulletin Board must be reporting issuers under Section 12 of the Exchange Act, and must be current in 
their reports under Section 13, in order to maintain price quotation privileges on the OTC Bulletin Board.  If we fail to remain current on our 
reporting requirements, we could be removed from the OTC Bulletin Board.  As a result, the market liquidity for our securities could be severely 
adversely  affected  by  limiting  the  ability  of  broker-dealers  to  sell  our  securities  and  the  ability  of  stockholders  to  sell  their  securities  in  the 
secondary market.  

ITEM 1B.                    UNRESOLVED STAFF COMMENTS                                                                              

Not applicable.  

ITEM 2.                       PROPERTIES  

We do not own real property. We currently lease two facilities, with approximately 12,000 square feet of corporate, research and development, 
and  warehouse  facilities,  located  at  20  382  Barents  Sea  Circle,  Lake  Forest,  CA  92630  and  five  (5)  executive  offices  located  at  402  West 
Broadway,  San  Diego,  CA  92101.  The  Company  currently  makes  base  lease  payments  of  approximately  $  10,000  per  month,  due  at  the 
beginning of each month . On August 24, 2009, the Company entered into the second amendment to the lease for its manufacturing and office 
space.  The  amendment  extended  the  lease  for  twelve  months  from  the  end  of  the  existing  lease  term  with  a  right  to  cancel  the  lease  with  a 
minimum of 120 day written notice at anytime as of November 30, 2009. In June 2010, Company entered into the third amendment to the lease 
for its manufacturing and office space. The amendment extended the lease for sixty months commencing July 1, 2010 with a right to cancel the 
lease  with  a  minimum  of  120  day  written  notice  at  anytime  as  of  December  31,  2012.  On  April  15,  2010,  the  Company  entered  into  office 
service  agreements  with  Regus  Management  Group,  LLC  (Lessor)  for  five  (5)  executive  offices  located  at  402  West  Broadway,  San  Diego, 
CA  92101. The office service agreements are for periods ranging from 3 to 7 months ending October 31, 2010. The office service agreements 
require base lease payments of approximately $5,100 per month. We believe that these facilities are adequate, suitable and of sufficient capacity 
to support our immediate needs. Additional space may be required, however , as we expand our research and development, manufacturing and 
selling and marketing activities.  

ITEM 3.                       LEGAL PROCEEDINGS  

In the ordinary course of business, we are at times subject to various legal proceedings and disputes.  We currently are not aware of any 
such legal proceedings or claim that we believe will have, individually or in the aggregate, a material adverse effect on our business, operating 
results or cash flows.  

ITEM 4.                       [REMOVED AND RESERVED]  

Not applicable.  

25 

 
 
 
 
 
 
 
 
 
 
 
 
  
  
ITEM 5.  

MARKET FOR REGISTRANT'S COMMON EQUITY, RELATED STOCKHOLDERS’ MATTERS AND ISSUER 
PURCHASES OF EQUITY SECURITIES  

PART II  

(a)             Market  Information.    The  Company’s  common  stock  is  quoted  on  the  OTC  Bulletin  Board  under  the  symbol 
“CYRX.OB.”  The following table shows the high and low sales price of the Company’s common stock for each quarter in the two years ended 
March 31, 2010:  

Fiscal Year 2010  
Quarter Ended March 31, 2010  
Quarter Ended December 31, 2009  
Quarter Ended September 30, 2009  
Quarter Ended June 30, 2009  
Fiscal Year 2009  
Quarter Ended March 31, 2009  
Quarter Ended December 31, 2008  
Quarter Ended September 30, 2008  
Quarter Ended June 30, 2008  

Common Stock  
Sales Price  

High  

Low  

$10.50  
$5.40  
$7.00  
$9.00  

$6.50  
$7.90  
$10.10  
$12.00  

$1.65  
$3.80  
$3.70  
$4.10  

$3.00  
$4.20  
$5.00  
$6.10  

(b)            Holders.   As of June 15, 2010, the number of stockholders of record of the Company's common stock was 162.  

(c)            Dividends.   No dividends on common stock have been declared or paid by the Company.  The Company intends to employ 

all available funds for the development of its business and, accordingly, does not intend to pay any cash dividends in the foreseeable future.  

(d)            Securities Authorized for Issuance Under Equity Compensation.   The information included under Item 12 of Part III of this 

Annual Report is hereby incorporated by reference into this Item 5 of Part II of this Annual Report.  

(e)                Recent  Sale  of  Unregistered  Securities  .    The  following  is  a  summary  of  transactions  by  the  Company  during  the  past 
quarter involving the issuance and sale of the Company’s securities that were not registered under the Securities Act of 1933, as amended (the 
“Securities Act”). All securities sold by the Company were sold to individuals, trusts or others who were accredited investors as defined under 
Regulation D under the Securities Act, as amended.  

On February 25, 2010, as a result of the Company’s public offering of units, the exercise price of certain outstanding warrants held by a 
former investment banker was reduced to $3.30 per share which resulted in a proportionate increase the number of shares of common stock that 
may be purchased upon the exercise of such warrants of 55,644 shares of common stock.  In addition, the Company issued fully vested warrants 
to purchase 17,500 shares of common stock representing 7% of the warrants issued to Enable and Bridgepointe in the public offering.    

During the three months ended March 31, 2010, the Company issued fully vested warrants to purchase 15,000 shares of common stock 

to Emergent Financial for continued shareholder support services.  The exercise price of the warrants was $1.91 per share.  

26 

 
 
 
   
   
 
 
 
 
 
   
   
 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
ITEM 6.                       SELECTED FINANCIAL DATA  

The following selected financial data has been derived from audited consolidated financial statements of the Company for each of the 
five years in the period ended March 31, 2010.  These selected financial summaries should be read in conjunction with the financial information 
contained  for  each  of  the  two  years  in  the  period  ended  March  31,  2010,  included  in  the  consolidated  financial  statements  and  notes  thereto, 
Management's Discussion and Analysis of Results of Operations and Financial Condition, and other information provided elsewhere herein.  

  Years Ended March 31,  
(in thousands, except per share data)  

2010  

2009  

2008 

2007  

2006  

Consolidated Statement of Operations 

Data:  

Revenues  
Cost of revenues  

Gross loss  

Selling, general and administrative       
Research and development  

  $  

 118     $ 

 35     $ 

 84     $ 

718       

(600 )      

3,313        
284        

546        

(511 )     

2,387        
297        

386        

(302 )     

2,551        
166        

67       
$ 
177        

(110 )     

1,899        
88        

152   

316    

(164 ) 

1,023    
254    

1,277    

Total operating expenses  

3,597       

2,684        

2,717        

1,987        

Loss from operations  
Other (expense) income:  

Interest income  
Interest expense  
Loss on sale of fixed assets  
Loss on extinguishment of debt  
Change in fair value of derivative 

liabilities  

Net loss before income taxes  
Income taxes  

Net loss  

Net loss per common share, basic and 

diluted  

Weighted average shares used in 

computing net loss per common share, 
basic and diluted  

(4,197 )     

(3,195 )     

(3.019 )     

(2,097 )     

(1,441 ) 

8        
(7,029 )     

(9 )       
—       
5,577        

32        
(2,693 )     

(10,847 )     
—      

50          

(1,593 )     

—       
—      

(228 )     

—       
—       

(80 ) 

—   
—   

(5,650 )     
2       

(16,703 )     
2         

(4,562 )     
2         

(2,325 )     
2 )     

(1,521 ) 
1     

(5,652 )   $ 

(16,705 )   $ 

(4,564 )   $ 

(2,327 )   $ 

(1,522 ) 

(1.13 )   $ 

(4.05 )   $ 

(1.16 )   $ 

(0.75 )   $ 

(0.51 ) 

  $ 

  $ 

5,011       

4,124       

3,943        

3,094        

2,989    

As of March 31,  
 (in thousands)  

2010  

2009  

2008 

2007  

2006  

Consolidated Balance Sheet Data:  
Cash, cash equivalents  
Working capital (deficit)  
Total assets  
Convertible notes, net  

   $ 

3,630      $ 
1,995        
4,777        
2,502        

250      $ 
(3,693 )     
1,573        
3,883        

2,231      $ 
981        
3,461        
902       

264      $ 
(478 )     
484        
96        

5    
(538 ) 
294    
—   

 
 
 
 
   
   
   
   
  
  
  
    
    
    
    
  
  
       
        
        
        
        
  
       
        
        
        
        
  
    
  
    
          
        
        
        
  
    
  
       
        
        
        
        
  
    
  
    
          
        
        
        
  
    
  
    
          
        
        
        
  
    
    
          
        
        
        
  
    
        
   
    
    
        
        
        
  
    
    
  
       
        
        
        
        
  
    
    
  
    
          
        
        
        
  
  
    
          
        
        
        
  
  
    
          
        
        
        
  
    
  
       
        
        
        
        
  
  
     
      
    
  
      
      
  
  
  
    
    
    
    
  
  
       
        
        
        
        
  
       
        
        
        
        
  
     
     
     
Other long-term obligations  
Accumulated deficit  
Total stockholders’ deficit  

1,478        
(45,944 )     
(915 )     

1,601       
(30,634 )     
(4,776 )     

1,711       
(13,929 )     
—       

1,857       
(9,365 )     
(2,288 )     

1,679    
(7,039 ) 
(2,150 ) 

27 

 
     
     
     
  
ITEM 7.   

MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF 
OPERATIONS  

This Annual Report on Form 10-K contains forward-looking statements that have been made pursuant to the provisions of the Private 
Securities  Litigation  Reform  Act  of  1995  and  concern  matters  that  involve  risks  and  uncertainties  that  could  cause  actual  results  to  differ 
materially  from  those  projected  in  the  forward-looking  statements.  Discussions  containing  forward-looking  statements  may  be  found  in  the 
material  set  forth  under  “Business,” “Management’s Discussion and Analysis  of  Financial Condition  and  Results  of  Operations”  and in other 
sections  of  this  Form  10-K.  Words  such  as  “may,”  “will,”  “should,”  “could,”  “expect,”  “plan,”  “anticipate,”  “believe,”  “estimate,”  “predict,”
“potential,” “continue” or similar words are intended to identify forward-looking statements, although not all forward-looking statements contain 
these words. Although we believe that our opinions and expectations reflected in the forward-looking statements are reasonable as of the date of 
this Annual Report on Form 10-K, we  cannot guarantee future results, levels  of  activity, performance or  achievements,  and our actual  results 
may  differ  substantially  from  the  views  and  expectations  set  forth  in  this  Annual  Report  on  Form  10-K.  We  expressly  disclaim  any  intent  or 
obligation  to  update  any  forward-looking  statements  after  the  date  hereof  to  conform  such  statements  to  actual  results  or  to  changes  in  our 
opinions  or  expectations.  Readers  are  urged  to  carefully  review  and  consider  the  various  disclosures  made  by  us,  which  attempt  to  advise 
interested parties of the risks, uncertainties, and other factors that affect our business, set forth in detail in Item 1A of Part I, under the heading 
“Risk Factors.”  

The following discussion and analysis should be read in conjunction with our consolidated financial statements and the related notes to 

those statements contained elsewhere in this Annual Report on Form 10-K.  

Overview  

We are a provider of an innovative cold chain frozen shipping system dedicated to providing superior, affordable cryogenic shipping 
solutions  that  ensure  the  safety,  status  and  temperature,  of  high  value,  temperature  sensitive  materials.  We  have  developed  cost  effective 
reusable  cryogenic  transport  containers  (referred  to  as  "shippers") capable  of  transporting  biological,  environmental  and  other  temperature 
sensitive materials at temperatures below 0° Celsius.  These dry vapor shippers are one of the first significant alternatives to dry ice shipping and 
achieve 10-plus day holding times compared to one to two day holding times with dry ice.  

Our value proposition comes from both providing safe transportation and an environmentally friendly, long lasting shipper, and through 
our value added services that offer a simple hassle-free solution for our customers.  These value-added services include an internet-based web 
portal  that  enables the  customer  to  initiate  scheduling,  shipping  and  tracking  of  the  progress  and  status  of  a shipment, and  provides  in-transit 
temperature and custody transfer monitoring services of the shipper. The CryoPort service also provides a fully ready charged shipper containing 
all freight bills, customs documents and regulatory paperwork for the entire journey of the shipper to our customers at their pick up location.  

Our principal focus has been the further development and commercial launch of CryoPort Express® Portal, an innovative IT solution 
for  shipping  and  tracking  high-value  specimens  through  overnight  shipping  companies,  and  our  CryoPort  Express®  Shipper,  a  dry  vapor 
cryogenic  shipper  for  the  transport  of  biological  and  pharmaceutical  materials.  A  dry  vapor  cryogenic  shipper  is  a  container  that  uses  liquid 
nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide storage temperatures below minus 
150°  Celsius.  The  dry  vapor  shipper  is  designed  using  innovative,  proprietary,  and  patented  technology  which  prevents  spillage  of  liquid 
nitrogen and pressure build up as the liquid nitrogen evaporates.  A proprietary foam retention system is employed to ensure that liquid nitrogen 
stays  inside  the  vacuum  container,  even  when  placed  upside-down  or  on  its  side,  as  is  often  the  case  when  in  the  custody  of  a  shipping 
company.  Biological specimens are stored in a specimen chamber, referred to as a “well,” inside the container and refrigeration is provided by 
harmless  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen  entrapped  within  the  foam  retention  system  surrounding  the  well.  Biological 
specimens transported using our cryogenic shipper can include clinical samples, diagnostics, live cell pharmaceutical products (such as cancer 
vaccines, semen and embryos, infectious substances) and other items that require and/or are protected through continuous exposure to frozen or 
cryogenic temperatures (below minus 150° Celsius).  

28 

 
   
   
   
   
   
   
   
 
  
  
During our early years, our limited revenue was derived from the sale of our reusable product line.  Our current business plan focuses 
on per-use  leasing  of  the  shipping  container  and  added-value  services  that  will  be  used  by  us  to  provide  an  end-to-end  and  cost-optimized 
shipping solution to life science companies moving pharmaceutical and biological samples in clinical trials and pharmaceutical distribution.  

We have incurred losses since inception and had an accumulated deficit of $45,943,809 through March 31, 2010.  

Results of Operations  

Years Ended March 31, 2010 and 2009  

Revenues . Net revenues were $117,956 in fiscal 2010, as compared to $35,124 in fiscal 2009. The low revenues in these years were primarily 
due  to  the  Company’s  shift  initiated  in  mid-2006  in  its  sales  and  marketing  focus  from  the  reusable  shipper  product  line.  The  Company 
discontinued sales of the reusable shippers to allow resources to focus on further development and launch of the CryoPort Express® System and 
its  introduction  into  the  biopharmaceutical  industry  sector  during  fiscal  2009,  which  resulted  in  the  increase  in  sales  period  over  period.  The 
slow increase in shipper revenues during the two fiscal years was also the  result of delays  in the Company  securing adequate funding for the 
manufacturing and full commercialization of the CryoPort Express® System.  

Gross loss and cost of revenues. Gross loss for 2010 was 508%, or $599,754 as compared to 1,455%, or $511,028, for fiscal 2009. The decrease 
in gross loss in fiscal 2010 as compared to fiscal 2009 was primarily the result of the increase in revenues from per-use leasing of the shipping 
containers.  During both periods, cost of sales exceeded sales due to fixed manufacturing costs and plant underutilization.  

Cost of revenues was $717,710 in fiscal 2010, as compared to $546,152 in fiscal 2009. The increase in costs of revenues sold during each of the 
two  years  is  primarily  the  result  of  the  write  off  due  to  the  discontinuation  of  the  reusable  shippers  and  increased  focus  on  the  CryoPort 
Express® System.  During both periods, cost of sales exceeded sales due to fixed manufacturing costs and plant underutilization.  

Research and development expenses . Research and development expenses were $284,847 in fiscal 2010, $297,378 in fiscal 2009. and  Current 
period  expenses  included  consulting  costs  associated  with  software  development  for  the  web  based  system  to  be  used  with  the  CryoPort 
Express®  Shipper,  and  other  research  and  development activity  related  to  the CryoPort  Express®  System,  as the  Company  strove  to  develop 
improvements in both the manufacturing processes and product materials for the purpose of achieving additional product cost efficiencies.  

29 

   
   
   
   
 
   
 
 
 
  
  
Selling, general and administrative expenses . Selling, general and administrative expenses were $3,312,635 in fiscal 2010, $2,387,287 in fiscal 
2009. The $925,348 increase in fiscal 2010 as compared to fiscal 2009 was primarily attributable to higher general and administrative expenses 
associated  with  an  increase  in  salaries  and  wages  of  $485,000  and  consulting  fees  of  $435,000  associated  with  the  Company’s  strategic 
partnering activities and debt restructuring.    

Stock-based  compensation  costs  .  Total  stock-based  compensation  costs  for  the  years  ended  March 31,  2010  and  2009  were  $559,561  and 
$289,497,  respectively.  During  the  year  ended  March 31,  2010,  we  granted  options  to employees  and  directors  to  purchase  190,553 shares  of 
common stock and warrants to purchase 21,000 shares of common stock at a weighted average exercise price of $3.53 per share.  The exercise 
prices of options and warrants were equal to the fair market value of our common stock at the time of grant.  

Interest  income  .  Interest  income  was  $8,164  in  fiscal  2010  and  $32,098  in  fiscal  2009.  The  decrease  in  interest  income  in  fiscal  2010  was 
primarily attributable to the overall reduction in interest rates and lower cash balances.  

Interest  expense  .  Interest  expense  was  $7,028,684  in  fiscal  2010,  $2,693,383  in  fiscal  2009.  Interest  expense  in  fiscal  2010  included 
amortization  of  debt  discount  of  $6,417,346  and  amortized  financing  fees  of  $159,516,  primarily  due  to  the  convertible  debentures  issued  in 
October  2007,  May  2008  and  the  Private  Placement  Debentures.  Included  in  fiscal  2010  and  fiscal  2009  is  the  impact  of  the  change  in 
accounting principle as required by the Debt with Conversion and Other Options Topic of the FASB Accounting Standards Codification, which 
required retrospective application.  

Loss on extinguishment of debt . The loss on extinguishment of debt of $10,846,573 in fiscal 2009 is due to  the resulting change in valuation of 
the debt and related warrants associated with amendments to the October 2007 Debentures entered into in April 2008, August 2008 and January 
2009  and  the  change  in  valuation  of  the  debt  and  related  warrants  associated  with  the  January  2009  amendment  to  the  May  2008 
Debentures  The loss consists of a combined total loss on extinguishment of debt on the October 2007 Debentures of $9,449,498 and $1,397,075 
on the May 2008 Debenture. There was no loss on extinguishment of debt during the year ended March 31, 2010.  

Gain (loss) on derivative valuation. Derivative valuation was a gain of $5,576,979 in fiscal 2010. In fiscal 2010, the gain was due to an adoption 
of a new accounting principle, which resulted in a reclassification of the fair value of warrants and embedded conversion features from equity to 
derivative  liabilities  that  are  marked  to  fair  value  at  each  reporting  period. The  impact  of  the  change  in  accounting  principle  and  change  in 
market value of the derivative liabilities during the current period resulted in the recognition of a gain  

Income taxes . We incurred net operating losses for the years ended March 31, 2010 and2009 and consequently did not pay any federal, state or 
foreign  income  taxes.  At  March  31,  2010,  we  had  federal  and  state  net  operating  loss  carryforwards  of  approximately  $27,463,000 and 
$27,621,000, respectively, which we have fully reserved due to the uncertainty of realization. Our federal tax loss carryforwards will begin to 
expire  in  fiscal  2019,  unless  utilized.  Our  California  tax  loss  carryforwards  will  begin  to  expire  in  fiscal  2013,  unless  utilized.  We  also  have 
federal  and  California  research  tax  credit  carryforwards  of  approximately  $14,000  and  $13,000,  respectively.  Our  federal  research  tax  credits 
will  begin  to  expire  in  fiscal  2026,  unless  utilized.  Our  California  research  tax  credit  carryforwards  do  not  expire  and  will  carryforward 
indefinitely until utilized.  

Liquidity and Capital Resources  

As of March 31, 2010, the Company had cash and cash equivalents of $3,629,886 and working capital of $1,994,934.  The Company’s 
working capital at March 31, 2010 included $334,363 of derivative liabilities, the balance of which represented the fair value of warrants related 
to the Company’s convertible debentures and also issued to consultants which were reclassified from equity during the year ended March 31, 
2010.  As of March 31, 2009, the Company had cash and cash equivalents of $249,758 and negative working capital of $3,693,015.  Historically, 
we have financed our operations primarily through sales of our debt and equity securities. Since March 2005, we have received net proceeds of 
approximately $15.7 million from sales of our common stock and the issuance of promissory notes, warrants and debt.  

30 

 
 
   
 
   
   
   
   
   
   
 
 
  
  
During fiscal 2010, we used $2,853,359 of cash for operations primarily as a result of the net loss of 5,651,561 including a non-cash 
gain of $5,576,979 due to the change in valuation of our derivative liabilities and non cash expenses of  $6,417,346 due primarily to discount 
amortization related to our convertible debt instruments. Offsetting the cash impact of our net operating loss (excluding non-cash items) was an 
increase  in  accrued  interest  payable  of  $335,830  primarily  due  to  our Private  Placement  Debentures  and  an  increase  in  accounts  payable  of 
$300,454 due primarily to increased general and administrative expenses.  

During fiscal 2009, we used $2,586,470 of cash from operations primarily as a result of the net loss of $16,705,151 offset by loss on 
extinguishment  of  debt  of  $10,846,573,  amortization  of  debt  discount  on  convertible  notes  of  $2,223,116,  amortization  of  deferred  financing 
costs related to the convertible notes of $42,284 non-cash stock-based compensation costs of $948,569, depreciation and amortization expense of 
$81,984 and a change in operating assets and liabilities of $17,618.  

Net  cash  used  in  investing  activities  totaled  $138,874  during  fiscal  2010,  primarily  attributable  to  the  decrease  in  restricted  cash  of 
$10,000,  offset  by  the  purchase  of  equipment  $31,926  and  the  purchase  of  intangible  assets  of  $116,948.  Net  cash  provided  by  investing 
activities  totaled  $485  during  fiscal  2009,  primarily  attributable  to  the  decrease  in  restricted  cash  of  $108,844,  offset  by  the  purchase  of 
equipment of $58,578 and the purchase of intangible assets of $49,781.  

Net cash provided by financing activities totaled $6,372,361 in fiscal 2010, primarily resulting from the receipt of the proceeds net of 
cash paid for offering costs from our public offering of common stock of $4,046,863, the proceeds from the issuance of  our Private Placement 
Debentures of $1,321,500 and gross proceeds from exercise of options and warrants of $1,437,100, which were partially offset by payment of 
deferred financing costs of $92,520 and payments on our related party notes payable and notes payable to officer of  $120,000 and $143,950, 
respectively.  Net cash provided by financing activities totaled $604,712 in fiscal 2009, primarily related to receipt of the proceeds from our May 
2008 Debentures of $1,122,500 and proceeds from exercise of options and warrants of $3,307, which were partially offset by payment on the 
October  2007  Convertible  Debentures  of  $117,720,  payment  of  deferred  financing  costs  of  $191,875,  payments  on  our  notes  payable  of 
$186,000 and payments on the line of credit of $25,500.  

As discussed in Note 1 of the accompanying consolidated financial statements, there exists substantial doubt regarding the Company’s 
ability  to  continue  as  a  going  concern.  The  Company  will  need  to  raise  additional  capital  through  one  or  more  methods,  including  but  not 
limited to, issuing additional equity, in order to fund our working capital needs and complete the commercial launch of our CryoPort Express® 
System.  On  February  25,  2010  we  completed  a  public  offering  of  units  consisting  of  1,666,667  shares  of  common  stock  and  warrants  to 
purchase 1,666,667 shares of common stock at an exercise price of $3.30, for gross proceeds of $5,000,001 and net proceeds of approximately 
$3,742,097.  As a result of these recent financings and the public offering, the Company had an aggregate cash and cash equivalents balance of 
$3,629,886 as of March 31, 2010 which will be used to fund the working capital required for minimal operations including limited inventory 
build up as well as limited sales efforts to advance the Company’s commercialization of the CryoPort Express® Shippers until additional capital 
is  obtained.  Management  has  estimated  that  cash  on  hand  as  of  March  31,  2010,  will  be  sufficient  to  allow  the  Company  to  continue  its 
operations only into the second quarter of fiscal 2011.   Company’s management recognizes that the Company must obtain additional capital for 
the  achievement  of sustained  profitable  operations.  Management’s plans include  obtaining  additional  capital  through equity and debt  funding 
sources; however, no assurance can be given that additional capital, if needed, will be available when required or upon terms acceptable to the 
Company.  

31 

 
 
 
 
   
   
   
 
  
  
We have never been profitable, and we might never become profitable. As of March 31, 2010, our accumulated deficit was $45,943,809 
(including  a  non-cash  valuation  adjustment  of  $9,657,893,  including  a  net  loss  of  $5,651,561  for  the  year  ended  March 31,  2010)  and  our 
stockholders’ deficit was $914,575.  

Contractual Obligations  

The following table summarizes our contractual obligations as of June 15, 2010 (in thousands):  

Operating Lease Obligations  
Convertible Debentures (1)  
Other Long-term Debt Obligations (2)  

Total:  

  $ 

  $ 

Total  

495      $ 
3,231        
1,010        

90      $ 
200        
150        

177      $ 
3,031        
206        

4,736      $ 

440      $ 

3,414      $ 

201      $ 
—       
192        

393      $ 

27   
—  
462   

489   

Less than  
 1 year  

Payments due by period  
1-3  
 years  

3-5  
 years  

More than  
 5 years  

__________________  
(1)  

The  Company  issued  convertible  debentures  in  October  2007  (the  “October  2007  Debentures”)  and  in  May  2008  (the  “May  2008 
Debentures,”  and  together  with  the  October  2007  Debentures,  the  “Debentures”).  The  Debentures  were  issued  to  four  institutional 
investors  and  have  an  outstanding  principal  balance  of  $3,230,568  as  of  March  31,  2010.  As  collateral  to  secure  our  repayment 
obligations to the holders of the Debentures we have granted such holders a first priority security interest in generally all of our assets, 
including our intellectual property.  

(2)  

 Represents  unsecured  indebtedness  owed  to  five  related  parties,  including  four  former  members  of  the  board  of  directors,  for  capital 
advances  made  to  the  Company  from  February  2001  through  March  2005.  These  notes  bear  interest  at  the  rate  of  6%  per  annum  and 
provide for aggregate monthly principal payments which began April 1, 2006 of $2,500, and which increased by an aggregate of $2,500 
every nine months to a maximum of $10,000 per month.  As of March 31, 2010, the aggregate principal payments totaled $10,000 per 
month.  Any remaining unpaid principal and accrued interest is due at maturity on various dates through March 1, 2015.  

  Critical Accounting Policies and Estimates  

Management’s discussion and analysis of financial condition and results of operations, as well as disclosures included elsewhere in this 
Annual  Report  on  Form  10-K,  are  based  upon  our  consolidated  financial  statements,  which  have  been  prepared  in  accordance  with  U.S. 
generally  accepted  accounting  principles.  Our  significant  accounting  policies  are  described  in  the  notes  to  the  audited  consolidated  financial 
statements  contained  elsewhere  in  this  Annual  Report  on  Form  10-K.  Included  within  these  policies  are  our  “critical  accounting  policies.”
Critical  accounting  policies  are  those  policies  that  are  most  important  to  the  preparation  of  our  consolidated  financial  statements  and  require 
management’s most subjective and complex judgment due to the need to make estimates about matters that are inherently uncertain. Although 
we believe that our estimates and assumptions are reasonable, actual results may differ significantly from these estimates. Changes in estimates 
and assumptions based upon actual results may have a material impact on our results of operations and/or financial condition.  

We believe that the critical accounting policies that most impact the consolidated financial statements are as described below.  

32 

 
 
   
   
   
   
 
   
   
 
  
  
  
  
    
  
    
    
    
    
  
    
    
  
     
        
        
        
        
    
  
     
        
        
        
        
    
   
   
  
Revenue Recognition  

Per Use Revenues  

We recognize revenues from product sales when there is persuasive evidence that an arrangement exists, when title has passed, the price 
is fixed or determinable, and we are reasonably assured of collecting the resulting receivable. The Company records a provision for claims based 
upon historical experience. Actual claims in any future period may differ from the Company’s estimates.  During its early years, the Company's 
limited revenue was derived from the sale of our reusable product line. The Company's current business plan focuses on per-use leasing of the 
shipping container and value-added services that will be used by us to provide an end-to-end and cost-optimized shipping solution.  

The  Company  provides  shipping  containers  to  their  customers  and  charges  a  fee  in  exchange  for  the  use  of  the  container.   The 
Company’ arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a period of time.  
The Company retains title to the containers and provides its customers the use of the container for a specified shipping cycle.  At the culmination 
of  the  customer’s  shipping  cycle,  the  container  is  returned  to  the  Company.  As  a  result  of  our  new  business  plan,  during  the  quarter  ended 
September  30,  2009,  the  Company  reclassified  the  containers  from  inventory  to  fixed  assets  upon  commencement  of  the  loaned-container 
program.   

Inventory  

The  Company  writes  down  its  inventories for estimated obsolescence  or  unmarketable  inventory  equal  to  the  difference between  the 
cost of inventory and the estimated market value based upon assumptions about future demand, future pricing and market conditions.  Inventory 
reserve costs are subject to estimates made by the Company based on historical experience, inventory quantities, age of inventory and any known 
expectations  for  product  changes.  If  actual  future  demands,  future  pricing  or  market  conditions  are  less  favorable  than  those  projected  by 
management,  additional  inventory  write-downs  may  be  required  and  the  differences  could  be  material.  Such  differences  might  significantly 
impact  cash  flows  from  operating  activities.  Once  established,  write-downs  are  considered  permanent  adjustments  to  the  cost  basis  of  the 
obsolete or unmarketable inventories.  

During its early years, the Company's limited revenue was derived from the sale of our reusable product line. The Company's current 
business plan focuses on per-use leasing of the shipping container and value-added services that will be used by us to provide an end-to-end and 
cost-optimized shipping solution.  

The Company provides shipping containers to its customers and charges a fee in exchange for the use of the container.  The Company’
arrangements  are  similar  to  the  accounting  standard  for  leases  since  they  convey  the  right  to  use  the  containers  over  a  period  of  time.   The 
Company retains title to the containers and provides its customers the use of the container for a specified shipping cycle.  At the culmination of 
the  customer’s  shipping  cycle,  the  container  is  returned  to  the  Company.   As  a  result  of  our  current  business  plan,  during  the  quarter  ended 
September  30,  2009,  the  Company  reclassified  the  containers  from  inventory  to  fixed  assets  upon  commencement  of  the  loaned-container 
program.  

33 

 
 
   
 
   
   
   
   
   
 
  
  
Fixed Assets  

Fixed  assets  are  stated  at  cost,  net  of  accumulated  depreciation  and  amortization.  Depreciation  and  amortization  of  fixed  assets  are 

provided using the straight-line method over the following useful lives:  

Furniture and fixtures    
Machinery and equipment   
Leasehold improvements   

7 years   
5-7 years   
Lesser of lease term or estimated useful life   

Betterments, renewals and extraordinary repairs that extend the lives of the assets are capitalized; other repairs and maintenance charges 
are  expensed  as  incurred.  The  cost  and  related  accumulated  depreciation  and  amortization  applicable  to  assets  retired  are  removed  from  the 
accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets are comprised of patents and trademarks and software development costs.  The Company capitalizes costs of obtaining 
patents  and  trademarks  which  are  amortized,  using  the  straight-line  method  over  their  estimated  useful  life  of  five  years.  The  Company 
capitalizes  certain  costs  related  to  software  developed  for  internal  use.  Software  development  costs  incurred  during  the  preliminary  or 
maintenance project stages are expensed as incurred, while costs incurred during the application development stage are capitalized and amortized 
using the straight-line method over the estimated useful life of the software, which is five years.  Capitalized costs include purchased materials 
and costs of services including the valuation  

Impairment of Long-Lived Assets  

The  Company  assesses  the  recoverability  of  its  long-lived  assets  by  determining  whether  the  depreciation  and  amortization  of  long-
lived assets over their remaining lives can be recovered through projected undiscounted cash flows.  The amount of long-lived asset impairment 
is  measured  based  on  fair  value  and  is  charged  to  operations  in  the  period  in  which  long-lived  asset  impairment  is  determined  by 
management.  Manufacturing fixed assets are subject to obsolescence potential as result of changes in customer demands, manufacturing process 
changes and changes in materials used.  The Company is not currently aware of any such changes that would cause impairment to the value of its 
manufacturing fixed assets.  

Stock-based Compensation  

We recognize compensation costs for all stock-based awards made to employees and directors. The fair value of stock-based awards is 
estimated at grant date using an option pricing model and the portion that is ultimately expected to vest is recognized as compensation cost over 
the requisite service period.  

We use the Black-Scholes option-pricing model to estimate the fair value of stock-based awards. The determination of fair value using 
the  Black-Scholes  option-pricing  model  is  affected  by  our  stock  price  as  well  as  assumptions  regarding  a  number  of  complex  and  subjective 
variables,  including  expected  stock  price  volatility,  risk-free  interest  rate,  expected  dividends  and  projected  employee  stock  option  exercise 
behaviors.  We  estimate  the  expected  term  based  on  the  contractual  term  of  the  awards  and  employees’  exercise  and  expected  post-vesting 
termination behavior.  

34 

 
   
   
   
   
   
   
   
   
   
   
 
  
  
  
  
  
At March 31, 2010, there was $471,401 of total unrecognized compensation cost related to non-vested stock options, which is expected 

to be recognized over a remaining weighted average vesting period of approximately 1.69 years.  

All transactions in which goods or services are the consideration received by non-employees for the issuance of equity instruments are 
accounted for based on the fair value of the consideration received or the fair value of the equity instrument issued, whichever is more reliably 
measurable. The measurement date used to determine the fair value of the equity instrument issued is the earlier of the date on which the third-
party performance is complete or the date on which it is probable that performance will occur.  

Derivative Liabilities  

Our issued and outstanding common stock purchase warrants and embedded conversion features previously treated as equity pursuant 
to the derivative treatment exemption were no longer afforded equity treatment, and the fair value of these common stock purchase warrants and 
embedded conversion features, some of which have exercise price reset features and some that were issued with convertible debt, from equity to 
liability status as if these warrants were treated as a derivative liability since their date of issue.  The common stock purchase warrants were not 
issued with the intent of effectively hedging any future cash flow, fair value of any asset, liability or any net investment in a foreign operation. 
The warrants do not qualify for hedge accounting, and as such, all future changes in the fair value of these warrants will be recognized currently 
in earnings until such time as the warrants are exercised or expire. These common stock purchase warrants do not trade in an active securities 
market, and as such, we estimate the fair value of these warrants using the Black-Scholes option pricing model.  

Convertible Debentures  

If  a  conversion  feature  of  conventional  convertible  debt  is  not  accounted  for  as  a  derivative  instrument  and  provides  for  a  rate  of 
conversion  that  is  below  market  value,  this  feature  is  characterized  as  a  beneficial  conversion  feature  (“BCF”).  A  BCF  is  recorded  by  the 
Company  as  a  debt  discount.   In  those  circumstances,  the  convertible  debt  will  be  recorded  net  of  the  discount  related  to  the  BCF.  The 
Company amortizes the discount to interest expense over the life of the debt using the effective interest method.  

Deferred Financing Costs  

Deferred financing costs represent costs incurred in connection with the issuance of the convertible notes payable.  Deferred financing 

costs are being amortized over the term of the financing instrument on a straight-line basis, which approximates the effective interest method.  

Income Taxes  

We  account  for  income  taxes  under  the  provision  of  the  Financial  Accounting  Standards  Board  (“FASB”)  Accounting  Standards 
Codification (“ASC”) 740, Income Taxes, or ASC 740. As of March 31, 2010 and 2009, there were no unrecognized tax benefits included in the 
balance sheet that would, if recognized, affect the effective tax rate. Based on the weight of available evidence, the Company's Management has 
determined that it is not more likely than not that the net deferred tax assets assets will be realized. Therefore, the Company has recorded a full 
valuation allowance against the net deferred tax assets. The Company's income tax provision consists of state minimum taxes.  

35 

 
   
   
   
 
   
 
   
 
   
 
 
 
  
  
Our practice is to recognize interest and/or penalties related to income tax matters in income tax expense. We had no accrual for interest 
or penalties on our consolidated balance sheets at March 31, 2010 and 2009, respectively and have not recognized interest and/or penalties in the 
consolidated  statement  of  operations  for  the  year  ended  March 31,  2010.  We  are  subject  to  taxation  in  the  United  States  and  various  state 
jurisdictions.  As of  March 31, 2010, the Company  is no longer subject to  U.S. federal examinations  for year  before 2006; and for  California 
franchise  and  income  tax  examinations  before  2005.  However,  to  the  extent  allowed  by  law,  the  taxing  authorities  may  have  the  right  to 
examine  prior  periods  where  net  operating  losses  were  generated  and  carried  forward,  and  make  adjustments  up  to  the  amount  of  the  net 
operating loss carry forward amount.  The Company is not currently under examination by U.S. federal or state jurisdictions.   

Adoption of Accounting Principle  

Equity-linked instruments (or embedded features) that otherwise meet the definition of a derivative are not accounted for as derivatives 
if certain criteria are met, one of which is that the instrument (or embedded feature) must be indexed to the entity’s own stock. Our warrant and 
convertible debt agreements contain adjustment (or ratchet) provisions and accordingly, we determined that these instruments are not indexed to 
our  common  stock.  As  a  result,  we  are  required  to  account  for  these  instruments  as  derivative  liabilities.  We  applied  these  provisions  to 
outstanding  instruments  as  of  April  1,  2009.  The  cumulative  effect  at  April 1,  2009  to  record,  at  fair  value,  a  liability  for  the  warrants  and 
embedded  conversion  features,  including  the  effects  on  the  discounts  on  the  convertible  notes of  $2,595,095,  resulted  in  an aggregate 
reduction to equity of $13,875,623 consisting of a reduction to additional paid-in capital of $4,217,730 and an increase in the accumulated deficit 
of  $9,657,893  to  reflect  the  change  in  the  accounting.  The  warrants  and  embedded  conversion  features  are  carried  at  fair  value  and  adjusted 
quarterly through earnings.  

The following table summarizes the effect of the adoption of accounting principle on the consolidated balance sheet as of April 1, 2009: 

Liabilities and Stockholders’ Deficit:  

Total liabilities  
Stockholders’ deficit:  
Common stock  
Additional paid-in capital  
Accumulated deficit  
Total stockholders’ deficit  

Total liabilities and stockholders’ deficit  

New Accounting Pronouncements  

As  
Previously  
Reported  

   As Adjusted  

Cumulative  
Adjustment  

   $ 

6,348,460   

   $ 

20,224,083      $ 

13,875,623   

4,186   
25,854,265   
(30,634,355 )        
(4,775,904 )         
   $ 
1,572,556   

4,186        
21,636,535        
(40,292,248 )      
(18,651,527 )       
1,572,556      $ 

—  
(4,217,730 ) 
(9,657,893 ) 
(13,875,623 )  
—  

   $ 

In  August  2010,  the FASB issued  Accounting  Standards Update No. 2010-05, Measuring  Liabilities  at  Fair  Value, or ASU  2010-05, 
which amends ASC 820 to provide clarification of a circumstance in which a quoted price in an active market for an identical liability is not 
available. A reporting entity is required to measure fair value using one or more of the following methods: 1) a valuation technique that uses a) 
the quoted price of the identical liability when traded as an asset or b) quoted prices for similar liabilities (or similar liabilities when traded as 
assets) and/or 2) a valuation technique that is consistent with the principles of ASC 820. ASU 2010-05 also clarifies that when estimating the fair 
value of a liability, a reporting entity is not required to adjust to include inputs relating to the existence of transfer restrictions on that liability. 
The adoption did not have a material impact on our consolidated financial statements.  

36 

 
 
   
 
 
   
 
   
   
 
  
  
  
  
    
  
     
  
     
       
  
        
  
        
          
  
     
     
     
     
     
     
  
ITEM 7A.  

QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK  

Changes in United States interest rates would affect the interest earned on our cash and cash equivalents and interest expense on our 

revolving credit facility.  

Based on our overall cash and cash equivalents interest rate exposure at March 31 , 20 10 , a near-term change in interest rates, based on 

historical movements, would not have a material adverse effect on our financial position or results of operations.  

All  outstanding  amounts  under  our  Revolving  Credit  Facility  bear  interest  at  a  variable  rate  equal  to  the  lender’s  prime  rate  plus  a 
margin  of  1.50%  or  5.0%,  whichever  is  higher.  Interest  is  payable  on  a  monthly  basis  and  may  expose  us  to  market  risk  due  to  changes  in 
interest rates. As of March 31, 2010, we had $90,388   outstanding under our Revolving Credit Facility. The interest rate at March 31, 2010 was 
5.00%.  A 10% change in interest rates on our Revolving Credit Facility would not have had a material effect on our net loss for the year ended 
March 31, 2010.  

We  have  operated  primarily  in  the  United  States.  Accordingly,  we  have  not  had  any  significant  exposure  to  foreign  currency  rate 

fluctuations.  

ITEM 8.  

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA  

Reference is made to the consolidated financial statements included in this Report at pages F-1 through F-31 .  

ITEM 9.  

CHANGES  IN  AND  DISAGREEMENTS  WITH  ACCOUNTANTS  ON  ACCOUNTING  AND  FINANCIAL 
DISCLOSURES  

None.  

ITEM 9A(T).  

CONTROLS AND PROCEDURES  

(a)  Evaluation  of  Disclosure  Controls  and  Procedures.    The  term  “disclosure  controls  and  procedures”  (defined  in  Rule 13a-15(e) 
under the Securities and Exchange Act of 1934 (the “Exchange Act”) refers to the controls and other procedures of a company that are designed 
to  ensure  that  information  required  to  be  disclosed  by  a  company  in  the  reports  that  it  files  under  the  Exchange  Act  is  recorded,  processed, 
summarized and reported within the required time periods. Under the supervision and with the participation of our management, including our 
chief  executive  officer  and  chief  financial  officer,  we  have  conducted  an  evaluation  of  the  effectiveness  of  the  design  and  operation  of  our 
disclosure  controls  and  procedures,  as  of  March  31,  2010.  Based  on  this  evaluation,  our  president  and  chief  executive  officer  and  our  chief 
financial officer concluded that our disclosure controls and procedures were effective as of March 31, 2010 to ensure the timely disclosure of 
required information in our Securities and Exchange Commission filings.  

Because  of  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect  misstatements.  In  addition,  the 
design of any system of control is based upon certain assumptions about the likelihood of future events, and there can be no assurance that any 
design will succeed in achieving its stated goals under all future events, no matter how remote.  Accordingly, even effective internal control over 
financial reporting can only provide reasonable assurance of achieving their control objectives.  

37 

   
 
   
 
 
 
 
 
 
 
 
 
 
 
 
  
  
(b)  Management’s Report on Internal Control Over Financial Reporting.    Management’s Report on Internal Control Over Financial 

Reporting which appears on the following page, is incorporated herein by this reference.  

(c) Changes in Internal Control over Financial Reporting.    There have been no changes in our internal control over financial reporting 
during the fourth quarter of the fiscal year ended March 31, 2010 that have materially affected, or are reasonably likely to materially affect, our 
internal control over financial reporting.  

ITEM 9B.  

OTHER INFORMATION  

None.  

38 

 
 
 
 
 
 
 
  
  
CRYOPORT, INC.  
MANAGEMENT’S REPORT ON  
INTERNAL CONTROL OVER FINANCIAL REPORTING  

The management of the Company is responsible for establishing and maintaining effective internal control over financial reporting and for the 
assessment of the effectiveness of internal control over financial reporting.  The Company’s internal control over financial reporting is a process 
designed, as defined in Rule 13a-15(f) under the Securities and Exchange Act of 1934, to provide reasonable assurance regarding the reliability 
of  financial  reporting  and  the  preparation  of  consolidated  financial  statements  for  external  purposes  in  accordance  with  generally  accepted 
accounting principles.  

The Company’s internal control over financial reporting is supported by written policies and procedures that:  

•   pertain  to  the  maintenance  of  records  that,  in  reasonable  detail,  accurately  and  fairly  reflect  the  transactions  and  dispositions  of  the 

Company’s assets;  

•   provide reasonable assurance that transactions are recorded as necessary to permit preparation of consolidated financial statements in 
accordance with generally accepted accounting principles, and that receipts and expenditures of the Company are being made only in 
accordance with authorizations of the Company’s management and directors; and  

•   provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company’s 

assets that could have a material effect on the consolidated financial statements.  

Because  of  its  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect  misstatements.  Projections  of  any 
evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that 
the degree of compliance with the policies or procedures may deteriorate.  

In connection with the preparation of the Company’s annual consolidated financial statements, management of the Company has undertaken an 
assessment  of  the  effectiveness  of  the  Company’s  internal  control  over  financial  reporting  based  on  criteria  established  in  Internal  Control  -
Integrated  Framework 
(“the  COSO 
Framework”).  Management’s assessment included  an evaluation of the  design  of  the Company’s internal control  over  financial  reporting and 
testing of the operational effectiveness of the Company’s internal control over financial reporting.  

the  Committee  of  Sponsoring  Organizations  of 

the  Treadway  Commission 

issued  by 

Based on this assessment, management has concluded that the Company’s internal control over financial reporting was effective as of March 31, 
2010.  

This  annual  report  does  not  include  an  attestation  report  of  the  Company’s  registered  public  accounting  firm  regarding  internal  control  over 
financial reporting. Management’s report was not subject to attestation b the Company’s registered public accounting firm pursuant to temporary 
rules of the Securities and Exchange Commission that permit the Company to provide only management’s report in this Annual Report.  

By:    

/s/ LARRY G. STAMBAUGH  

   Larry G. Stambaugh,  

President & Chief Executive 
Officer, and Director  

June 21, 2010  

By:    

/s/  CATHERINE M. DOLL  

   Catherine  M. Doll  

Chief Financial Officer  

 
 
   
   
   
   
 
 
   
   
   
   
   
   
   
 
   
   
   
   
 
   
 
 
  
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
39 

  
ITEM 10.  

DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE  

PART III  

The information required by this Item regarding our directors, executive officers and committees of our board of directors is 
incorporated  by  reference  to  the  information  set  forth  under  the  captions  “Election  of  Directors”  and  “Executive  Compensation  and  Related 
Matters” in our 2010 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 2010 (the “2010 
Definitive Proxy Statement”).  

Information required by this Item regarding Section 16(a) reporting compliance is incorporated by reference to the information set forth 

under the caption “Section 16(a) Beneficial Ownership Reporting Compliance” in our 2009 Proxy Statement.  

Information required by this Item regarding our code of ethics is incorporated by reference to the information set forth under the caption 

“Corporate Governance” in Part I of this Annual Report on Form 10-K.  

ITEM 11.  

EXECUTIVE COMPENSATION  

The  information  required  by  this  Item  is  incorporated  by  reference  to  the  information  set  forth  under  the  caption  “Executive 
Compensation and Related Matters” in our 2010 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended 
March 31, 2010.  

ITEM 12.  

SECURITY  OWNERSHIP  OF  CERTAIN  BENEFICIAL  OWNERS  AND  MANAGEMENT  AND  RELATED 
STOCKHOLDER MATTERS  

The information required by this Item is incorporated by reference to the information set forth under the caption “Security Ownership of 
Directors and Executive Officers and Certain Beneficial Owners” in our 2010 Definitive Proxy Statement to be filed within 120 days after the 
end of our fiscal year ended March 31, 2010.  

ITEM 13.  

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE  

The information required by this Item is incorporated by reference to the information set forth under the captions “Certain Relationships 
and  Related  Transactions”  and  “Compensation  Committee  Interlocks  and  Insider  Participation”  in  our  2010  Definitive  Proxy  Statement  to  be 
filed within 120 days after the end of our fiscal year ended March 31, 2010.  

ITEM 14.   

PRINCIPAL ACCOUNTING FEES AND SERVICES  

The  information  required  by  this  Item  is  incorporated  by  reference  to  the  information  set  forth  under  the  caption  “Independent 
Registered  Public  Accounting  Firm  Fees”  in our  2010  Definitive Proxy Statement  to  be  filed  within 120 days  after  the  end  of  our fiscal  year 
ended March 31, 2010.  

40 

 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
  
  
PART IV  

ITEM 15:  Exhibits and Financial Statement Schedules.  

(a)  

Financial Statements  

(1)   

Index to Consolidated Financial Statements  

The financial statements required by this item are submitted in a separate section beginning on page F-1 of this report.  

   Report of Independent Registered Public Accounting Firm  

   Consolidated Balance Sheets at March 31, 2010 and 2009  

   Consolidated Statements of Operations the years ended March 31, 2010 and 2009  

   Consolidated Statements of Stockholders’ Deficit for each years ended March 31, 2010 

and 2009  

   Consolidated Statements of Cash Flows for the years ended March 31, 2010 and 2009  

   Notes to Consolidated Financial Statements  

F-2 

F-3 

F-4 

F-5 

F-6 

F-8 

2.   Financial Statement Schedules  
   All financial statement schedules are omitted because they were not required or the required information is included in the 

Consolidated Financial Statements and the related Notes thereto.  

3.   Exhibit Index  

See Exhibit Index  

41 

 
   
   
   
   
   
   
 
   
   
  
  
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
CRYOPORT, INC.  

INDEX TO CONSO LIDATED FINANCIAL STATEMENTS  

Report of Independent Registered Public Accounting Firm  
Consolidated Balance Sheets as of March 31, 2010 and 2009  
Consolidated Statements of Operations for the years ended March 31, 2010 and 2009  
Consolidated Statements of Stockholders’ Deficit for the years ended March  31, 2010 and 2009  
Consolidated Statements of Cash Flows for the years ended March  31, 2010 and 2009  
Notes to Consolidated Financial Statements  

Page  
F-2 
F-3 
F-4 
F-5 
F-6 
F-8 

F-1 

   
 
   
 
 
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

To the Board of Directors of  
CryoPort, Inc.  

We  have  audited  the  accompanying  consolidated  balance  sheets  of  CryoPort,  Inc.  (the  “Company”)  as  of  March  31,  2010  and  2009,  and  the 
related  consolidated  statements  of  operations,  stockholders'  deficit  and  cash  flows  for  the  years  then  ended.  These  consolidated  financial 
statements  are  the  responsibility  of  the  Company's  management.  Our  responsibility  is  to  express  an  opinion  on  these  consolidated  financial 
statements based on our audits.  

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards 
require  that  we  plan  and  perform  the  audits  to  obtain  reasonable  assurance  about  whether  the  consolidated  financial  statements  are  free  of 
material  misstatement.  An  audit  includes  examining,  on  a  test  basis,  evidence  supporting  the  amounts  and  disclosures  in  the  consolidated 
financial  statements.  The  Company  is  not  required  to  have,  nor  were  we  engaged  to  perform,  an  audit  of  its  internal  control  over  financial 
reporting.  Our  audits  included  consideration  of  internal  control  over  financial  reporting  as  a  basis  for  designing  audit  procedures  that  are 
appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over 
financial reporting. Accordingly, we express no such opinion.  An audit also includes assessing the accounting principles used and significant 
estimates  made  by  management,  as  well  as  evaluating  the  overall  financial  statement  presentation.  We  believe  that  our  audits  provide  a 
reasonable basis for our opinion.  

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of CryoPort, 
Inc.  at  March  31,  2010  and  2009,  and  the  results  of  its  operations  and  its  cash  flows  for  the  years  then  ended  in  conformity  with  accounting 
principles generally accepted in the United States of America.  

As discussed in Note 1 to the consolidated financial statements, management adopted a new accounting policy for derivative instruments in 
fiscal 2010.  

The  accompanying  consolidated  financial  statements  have  been  prepared  assuming  that  the  Company  will  continue  as  a  going  concern.   As 
discussed in Note 1 to the consolidated financial statements, the Company has incurred recurring losses and negative cash flows from operations 
since inception.  Although the Company has working capital of $1,994,934 and cash and cash equivalents balance of $3,629,886 at March 31, 
2010, management has estimated that cash on hand, which include proceeds from the offering received in the fourth quarter of fiscal 2010, will 
only be sufficient to allow the Company to continue its operations only into the second quarter of fiscal 2011.  These matters raise substantial 
doubt about the Company's ability to continue as a going concern. Management's plans in regard to these matters are also described in Note 1.  
The consolidated financial statements do not include any adjustments relating to the recoverability and classification of asset carrying amounts or 
the amount and classification of liabilities that might result should the Company be unable to continue as a going concern.  

/s/ KMJ Corbin & Company LLP  

Costa Mesa, California  
June 21, 2010  

F-2 

   
 
 
 
 
 
   
 
 
   
   
CRYOPORT, INC.  

CONSOLIDATED BALANCE SHEETS  

Current assets:  

ASSETS  

Cash and cash equivalents  
Restricted cash  
Accounts receivable, net of allowances of $1,500 in 2010 and $600 in 2009  
Inventory  
Other current assets  

Total current assets  

Property and equipment, net  
Intangible assets, net  
Deferred financing costs  
Deposits and other assets  

Total assets  

Current liabilities:  

LIABILITIES AND STOCKHOLDERS’ DEFICIT  

March 31,  

2010  

2009  

  $ 

3,629,886      $ 
90,404        
81,036        
—       
104,014        
3,905,340        
559,241        
311,965        
—       
—       

249,758   
101,053   
2,546   
530,241   
170,399   
1,053,997   
189,301   
264,364   
3,600   
61,294   

  $ 

4,776,546      $ 

1,572,556   

  $ 

Accounts payable  
Accrued compensation and related expenses  
Accrued warranty costs  
Convertible notes payable, net of discount of  $13,586  in 2009  
Current portion of convertible debentures  payable and accrued interest, net of discount of  
$0 in  2010 and $662,583 in 2009  
Line of credit and accrued interest    
Current portion of related party notes payable  
Current portion of note payable to former officer   
Derivative liabilities  
Other accrued expenses  

Total current liabilities  

Related party notes payable and accrued interest, net of current portion  
Note payable to former officer and accrued interest, net of current portion  
Convertible debentures payable, net of current portion and discount of $728,109 in 2010  and 

$2,227,205 in 2009, respectively  

Total liabilities  

Commitments and Contingencies  
Stockholders’ deficit:  

Common stock, $0.001 par value; 250,000,000 shares authorized; 8,136,619 and 4,186,194 

shares issued and outstanding at March 31, 2010 and 2009, respectively.  

Additional paid-in capital  
Accumulated deficit  

Total stockholders’ deficit  

823,653      $ 
312,002        
—       
—       

200,000        
90,388        
150,000        
—       
334 ,363        
—       
1,910,406        
1,478,256        
—       

218,433   
206,180   
18,743   
46,414   

3,836,385   
90,310   
150,000   
90,000   
—  
90,547   
4,747,012   
1,533,760   
67,688   

2,302,459        

—  

5,691,121        

6   

6,348,460   

8,137        
45,021,097        
(45,943,809 )      

4,186   
25,854,265   
(30,634,355 )  

(914,575 )      

(4,775,904 )  

Total liabilities and stockholders’ deficit  

  $ 

4,776,546      $ 

1,572,556   

See accompanying notes.  

   
   
 
   
   
   
  
  
  
  
  
    
  
    
      
  
    
      
  
    
    
    
    
    
    
    
    
    
  
    
        
    
  
    
        
    
    
        
    
    
        
    
    
    
    
    
    
    
    
    
    
    
    
    
    
  
    
       
  
    
  
    
        
    
    
        
    
    
        
    
    
    
    
  
    
        
    
    
  
    
        
    
F-3 

CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF OPERATIONS  

Revenues  
Cost of revenues  

Gross loss  
Costs and expenses:  

Selling, general and administrative  
Research and development  

Total costs and expenses  

Loss from operations  
Other (expense) income:  

Interest income  
Interest expense  
Loss on sale of  property and equipment  
Loss on extinguishment of debt  
Change in fair value of derivative liabilities  

Total other expense, net  

Loss before income taxes  

Income taxes  

Net loss  

Net loss per common share, basic and diluted  

Years Ended March 31,  
2009  
2010  

   $  

117,956      $ 
717,710        

35,124    
546,152   

(599,754)       

(511,028)   

3,312,635        
284,847        

2,387,287   
297,378   

3,597,482        
(4,197, 236)        

2,684,665   
(3,195,693)   

8,164        
(7,028,684)       
(9,184)       
—       
5,576,979         

32,098   
(2,693,383)   
 —  
(10,846,573)   
—  

(1,452,725)       

(13,507,858)   

(5,649, 961)       

(16,703,551)   

1,600       

1,600   

   $ 

(5,651,561)     $ 

(16,705,151)   

   $ 

(1.13)     $ 

(4.05)   

Basic and diluted weighted average common shares outstanding  

5,011,057        

4,123,819   

See accompanying notes.  

F-4 

   
   
   
   
   
  
  
  
  
   
    
  
     
  
    
     
        
  
     
        
        
  
     
     
  
    
     
        
  
     
     
        
        
  
     
     
    
     
     
  
    
     
        
  
     
  
       
        
  
    
  
       
        
  
    
  
    
     
        
  
  
    
     
        
  
  
    
     
        
  
     
CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ DEFICIT  

Balance at March 31, 2008  
Adjust beginning balance for reverse stock 

split effected in February 2010  

Issuance of common stock for conversion 
of convertible debentures including 
accrued interest  

Cancellation of common stock issued for 

debt principal reduction  
Issuance of common stock for 
extinguishment of debt  

Change in fair value of warrants issued in 
connection with debt modifications  
Issuance of common stock to consultants  
Exercise of stock options and warrants for 

cash  

Cashless exercise of warrants  
Debt discount related to convertible 

debentures  

Share-based compensation related to stock 

options and warrants issued to 
consultants, employees and directors  

Net loss  

Balance at March 31, 2009  
Cumulative effect related to adoption of 

new accounting principle  

Issuance of common stock for conversion 
of convertible notes payable including 
accrued interest  

Issuance of common stock for conversion 
of convertible debentures and accrued 
interest  

Reclassification of derivative liability to 

additional paid-in capital upon 
conversion of convertible notes and 
debentures  

Reclassification of derivative liability to 

additional paid-in capital upon 
effectively fixing conversion feature and 
warrant price  

Estimated fair value of warrants issued as 

commission for debt financing  

Issuance of common stock for services  
Exercise of warrants for cash, net  
Cashless exercise of warrants and stock 

options  

Issuance of units in public offering, net of 

offering costs of $1,257,904  

Common Stock  

Shares  

Amount  

Additional  
 Paid-in  
Capital  

     Accumulated       
Deficit  

Total  
 Stockholders’    
Deficit  

40,928,225        

40,929        

13,888,094        

(13,929,204 )      

(181 ) 

(36,835,402 )      

(36,836 )      

36,836        

—       

—  

3,890        

4        

5,442        

—       

5,446   

(14,014 )      

(14 )      

(117, 706 )      

—       

(117,720 ) 

40,000        

40        

163,960        

—       

164,000   

—       
40,224        

8,269        
15,002        

—       
40        

8        
15        

9,824,686        
249,062        

3,299        
(15 )      

—       
—       

—       
—       

9,824,686   
249,102   

3,307   
—  

—       

—       

991,884        

—       

991,884   

—       
—       

—       
—       

808,723        
—       

—       
(16,705,151 )      

808,723   
(16,705,151 ) 

4,186,194        

4,186        

25,854,265        

(30,634,355 )      

(4,775,904 ) 

—       

—       

(4,217,730 )      

(9,657,893 )      

(13,875,623 ) 

519,186        

519        

1,459,682        

—       

1,460,201   

1,236,316        

1,237        

4,267,446        

—       

4,268,683   

—       

—       

2,728,459        

—       

2,728,459   

—       

—       

9,009,329        

—       

9,009,329   

—       
33,490        
479,033        

—       
33        
479        

63,396        
166,061        
1,359,989        

15,753        

16        

(16 )      

—       
—       
—       

—       

63,396   
166,094   
1,360,468   

—  

1,666,667        

1,667        

3,740,430        

—       

3,742,097   

   
   
 
  
  
    
  
  
    
    
    
    
  
  
    
      
      
      
      
  
    
    
    
    
    
    
    
    
    
    
    
    
  
    
        
        
        
        
    
   
    
    
    
    
    
    
    
    
    
    
    
Share-based compensation related to stock 

options and warrants issued to 
consultants, employees and directors  

Fractional share adjustment for stock split       
Net loss  

—       
(20 )      
—       

—       
—       
—       

589,786        
—       
—       

—       
—       
(5,651,561 )      

589,786   
—  
(5,651,561 ) 

Balance at March 31, 2010  

8,136,619      $ 

8,137      $ 

45,021,097      $ 

(45,943,809 )    $ 

(914,575 ) 

See accompanying notes.  

F-5 

   
   
    
    
  
    
        
        
        
        
    
    
CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF CASH FLOWS  

OPERATING ACTIVITIES  

Net loss  
Adjustments to reconcile net loss to net cash used in operating activities:  

Depreciation and amortization  
Amortization of deferred financing costs  
Amortization of debt discount  
Stock issued to consultants  
Fair value of stock options and warrants issued to consultants, employees and directors  
Change in fair value of derivative instruments  
Loss on extinguishment of debt  
Loss on sale of assets  
Loss on disposal of Cryogenic shippers  
Interest accrued on restricted cash  
Changes in operating assets and liabilities:  

Accounts receivable, net  
Inventory  
Prepaid expenses and other assets  
Accounts payable  
Accrued expenses  
Accrued warranty costs  
Accrued compensation and related expense  
Accrued interest  
Net cash used in operating activities  

INVESTING ACTIVITIES  

Decrease in restricted cash  
Purchases of  intangibles  
Purchases of property and equipment  

Net cash (used in) provided by investing activities  
FINANCING ACTIVITIES  

Proceeds from issuance of common stock, net of cash paid for issuance costs  
Proceeds from borrowings under convertible notes  
Repayment of convertible debt  
Repayment of line of credit  
Repayment of deferred financing costs  
Repayment of notes payable  
Payment of related party notes payable  
Repayments of  note payable to officer  

Payment of fees associated with the exercise of warrants  
Proceeds from exercise of options and warrants  
Net cash provided by financing activities  

Net change in cash and cash equivalents  
Cash  and cash equivalents, beginning of year  
Cash and cash equivalents, end of year  

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION  

Cash paid during the year for:  
Interest  
Income taxes  

Years Ended March 31, 2010  

2010  

2009  

  $ 

(5,651,561 )    $ 

(16,705,151 ) 

150,093       
159,516       
6,417,346       
166,094       
865,895       
(5,576,979 )     
—      
9,184      
21,285      
649       

(78,490 )     
81,012       
(50,219 )     
300,454       
(90,547 )     
(18,743 )     
105,822       
335,830       
(2,853,359 )     

10,000       
(116,948 )     
(31,926 )     
(138,874 )     

4,046,863      
1,321,500       
—      
—      
(92,520 )     
—      
(120,000 )     
(143,950 )     

(76,632 )     
1,437,100       
6,372,361       
3,380,128       
249,758       
3,629,886     $ 

81,984   
42,284   
2,223,116   
249,102   
699,467   
—  
10,846,573   
—  
—  
(6,227 ) 

18,865   
(408,289 ) 
7,329   
(15,865 ) 
(8,101 ) 
(11,250 ) 
68,077   
331,616   
(2,586,470 ) 

108,844   
(49,781 ) 
(58,578 ) 
485   

—  
1,122,500   
(117,720 ) 
(25,500 ) 
(191,875 ) 
(12,000 ) 
(120,000 ) 
(54,000 ) 

—  
3,307   
604,712   
(1,981,273 ) 
2,231,031   
249,758   

13,875       
1,600       

95,360   
800   

  $ 

   
   
   
   
  
  
  
  
  
    
  
    
      
  
    
        
    
    
    
    
    
    
    
    
    
    
    
    
        
    
    
    
    
    
    
    
    
    
    
    
        
    
    
    
    
    
    
        
    
    
    
    
    
    
  
    
    
  
    
        
    
    
    
    
    
    
  
    
        
    
  
    
        
    
    
      
    
      
    
    
F-6 

CRYOPORT, INC. 

CONSOLIDATED STATEMENTS OF CASH FLOWS (CONTINUED)  

SUPPLEMENTAL DISCLOSURE OF NON-CASH ACTIVITIES:  
Offering costs in connection with equity financing  
Deferred financing costs in connection with convertible debt financing and debt modifications  
Warrants issued as deferred financing costs in connection with convertible debt financing  
Purchase of intangible assets with warrants  
Debt discount in connection with convertible  debt financing  
Conversion of debt and accrued interest to common stock  
Reclassification of embedded conversion feature to equity upon conversion  
Cashless exercise of warrants and stock options  
Cancellation of shares issued for debt principal reduction  
Change in fair value of warrants issued in connection of debt modification  
Cumulative effect of accounting change to debt discount for derivative liabilities  
Cumulative effect of accounting change to accumulated deficit for derivative liabilities  
Cumulative effect of accounting change to additional paid-in capital for derivative liabilities  
Reclassification of inventory to property and equipment  
Fair value of shares issued in connection with debt modifications  
Addition of principal due to debt modifications  
Reclassification of derivative liabilities to additional paid in capital upon effectively fixing conversion 
feature and warrant price  

  $ 
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  
  $  

304,766     $  
—    $  
—    $  
—    $  
1,080,201     $  
5,728,884     $  
2,728,459     $  
16     $  
—    $  
—    $  
2,595,095     $  
9,657,893     $  
4,217,730     $  
449,229     $  
—    $  
646,369     $  

—  
3,600   
117,530   
232,964   
1,263,586   
5,446   
—  
150   
117,720   
9,824,686   
—  
—  
—  
—  
164,000   
1,012,232   

  $  

9,009,329     $ 

—  

See accompanying notes.  

F-7 

   
   
   
    
   
    
        
    
CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS  

Note 1.  Organization and Summary of Significant Accounting Policies  

The Company  

CryoPort,  Inc.  (the  “Company”  or  “we”)  is  a  provider  of  an  innovative  cold  chain  frozen  shipping  system  dedicated  to  providing 
superior,  affordable  cryogenic  shipping  solutions  that  ensure  the  safety,  status  and  temperature  of  high  value,  temperature  sensitive 
materials.  The Company has developed cost-effective reusable cryogenic transport containers (referred to as a “shipper”) capable of transporting 
biological, environmental and other temperature sensitive materials at temperatures below 0° Celsius.  These dry vapor shippers are one of the 
first  significant  alternatives  to  using  dry  ice  and  achieve  10-plus  day  holding  times  compared  to  one  to  two  day  holding  times  with  dry  ice 
(assuming no re-icing during transit).  The Company’s value proposition comes from both providing safe transportation and an environmentally 
friendly, long lasting shipper, and through its value-added services that offer a simple hassle-free solution for its customers.  These value-added 
services include an internet-based web portal that enables the customer to initiate scheduling, shipping and tracking  the progress and status of a 
shipment, and provide in-transit temperature and custody transfer monitoring of the shipper.  The CryoPort service also provides a fully ready 
charged shipper containing all freight bills, customs documents and regulatory paperwork for the entire journey of the shipper to its customers at 
their pick up location.  

The Company's principal focus has been the further development and commercial launch of CryoPort Express® Portal, an innovative IT 
solution for shipping and tracking high-value specimens through overnight shipping companies, and its CryoPort Express® Shipper, a dry vapor 
cryogenic  shipper  for  the  transport  of  biological  and  pharmaceutical  materials.  A  dry  vapor  cryogenic  shipper  is  a  container  that  uses  liquid 
nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide storage temperatures below minus 
150° Celsius. The dry vapor shipper is designed using innovative, proprietary, and patent pending technology which prevents spillage of liquid 
nitrogen and pressure build up as the liquid nitrogen evaporates.  A proprietary foam retention system is employed to ensure that liquid nitrogen 
stays  inside  the  vacuum  container,  even  when  placed  upside-down  or  on  its  side  as  is  often  the  case  when  in  the  custody  of  a  shipping 
company.  Biological specimens are stored in a specimen chamber, referred to as a “well,” inside the container and refrigeration is provided by 
harmless  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen  entrapped  within  the  foam  retention  system  surrounding  the  well.  Biological 
specimens transported using our cryogenic shipper can include clinical samples, diagnostics, live cell pharmaceutical products (such as cancer 
vaccines, semen and embryos, and infectious substances) and other items that require and/or are protected through continuous exposure to frozen 
or cryogenic temperatures (less than minus 150 ° Celsius).  

The Company recently entered into its first strategic relationship with a global courier on January 13, 2010 when it signed an agreement 
with  Federal  Express  Corporation  (“FedEx”)  pursuant  to  which  the  Company  will  lease  to  FedEx  such  number  of  its  cryogenic  shippers  that 
FedEx shall, from time to time, order for FedEx’s customers. Under this agreement, FedEx has the right to and shall, on a non-exclusive basis, 
promote, market and sell transportation of the Company’s shippers and its related value-added goods and services, such as its data logger, web 
portal and planned CryoPort Express® Smart Pak System .  

Going Concern  

As reported in the Report of Independent Registered Public Accounting Firm on the Company’s March 31, 2010 and 2009 consolidated 
financial statements, the Company has incurred recurring losses and negative cash flows from operations since inception.  The Company has not 
generated  significant revenues  from  operations  and has  no  assurance  of any  future significant  revenues.  The Company  generated  revenues of 
only  $117,956,  incurred  a  net  loss  of  $5,651,561  and  used  cash  of  $2,853,359  in  its  operating  activities  during  the  year  ended  March  31, 
2010.  These factors raise substantial doubt about the Company’s ability to continue as a going concern.  

During the period from March 30, 2009 through March 31, 2010, the Company raised gross proceeds of $1,381,500 under the Private 
Placement Debentures (see Note 8) and gross proceeds of $1,437,100 (see Note 10) from the exercise of options and warrants. On February 25, 
2010 the Company completed a public offering of units consisting of 1,666,667 shares of common stock and 1,666,667 warrants to purchase one 
share of common stock at an exercise price of $3.30, for gross proceeds of $5,000,001 and net proceeds of $3,742,097. Each unit consisting of 
one share, together with one warrant to purchase one share, was priced at $3.00. As a result of these recent financings and the public offering, the 
Company had an aggregate cash and cash equivalents and of $3,629,886 as of March 31, 2010 which will be used to fund the working capital 
required for minimal operations including limited shipper build up as well as limited sales efforts to advance the Company’s commercialization 
of the CryoPort Express® Shippers until additional capital is obtained.  Management has estimated that cash on hand as of March 31, 2010, will 
be  sufficient  to  allow  the  Company  to  continue  its  operations  only  into  the  second  quarter  of  fiscal  2011.  The  Company’s  management 
recognizes that the Company must obtain additional capital for the achievement of sustained profitable operations.  Management’s plans include 
obtaining additional capital through equity and debt funding sources; however, no assurance can be given that additional capital, if needed, will 

   
   
       
   
   
   
   
   
   
   
be available when required or upon terms acceptable to the Company.  

Basis of Presentation  

The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in 

the United States of America. (“GAAP”)  

Reverse Stock Split  

On February  5,  1010,  we  effected  a  10-for-1  reverse  stock  split  of  all  of  our  issued  and  outstanding  shares  of  common  stock (the 
"Reverse  Stock  Split")  by  filing  a  Certificate  of  Amendment  to Amended  and  Restated  Articles  of  Incorporation  with  the  Secretary  of  State 
of Nevada.  The  par  value  and  number  of  authorized  shares  of  our  common  stock  remained  unchanged.  The  number  of  shares  and  per  share 
amounts  included  in  the  consolidated  financial  statements  and  the  accompanying  notes  have  been  adjusted  to  reflect  the  Reverse  Stock  Split 
retroactively. Unless otherwise indicated, all references to number of shares, per share amounts and earnings per share information contained in 
this report give effect to the Reverse Stock Split.  

F-8 

   
   
   
   
   
Principles of Consolidation  

The consolidated financial statements include the accounts of CryoPort, Inc. and its wholly owned subsidiary, CryoPort Systems, Inc. 

All intercompany accounts and transactions have been eliminated.  

Use of Estimates  

The  preparation  of  consolidated  financial  statements  in  conformity  with  GAAP  requires  management  to  make  estimates  and 
assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial 
statements and the reported amounts of revenues and expenses during the reporting periods. Actual results could differ from estimated amounts. 
The  Company’s  significant  estimates  include  allowances  for  doubtful  accounts  and  sales  returns,  recoverability  of  long-lived  assets,  accrued 
warranty costs, deferred tax assets and their accompanying valuations, product liability reserves, valuation of derivative liabilities and  valuation 
of common stock, warrants and stock options issued for products or services.  

Fair Value of Financial Instruments  

The  Company’s  financial  instruments  consist  of  cash  and  cash  equivalents,  restricted  cash,  accounts  receivable,  related-party  notes 
payable, note payable to officer, a line of credit, convertible notes payable, accounts payable and accrued expenses. The carrying value for all 
such instruments  approximates fair value at March 31, 2010 and 2009. The difference between the fair value and recorded values of the related 
party notes payable is not significant.  

Cash and Cash Equivalents  

The Company considers highly liquid investments with original maturities of 90 days or less to be cash equivalents.  

Concentration of Credit Risk  

Cash and cash equivalents  

The  Company  maintains  its  cash  accounts  in  financial  institutions.  Accounts  at  these  institutions  are  insured  by  the  Federal  Deposit 
Insurance  Corporation  (“FDIC”).  Effective  October  3,  2008,  the  Emergency  Economic  Stabilization  Act  of  2008  raised  the  FDIC  deposit 
coverage  limits  to  $250,000  per  owner  from  $100,000  per  owner  through  January  1,  2014.   At  March  31,  2010  and  2009,  the  Company  had 
$3,490,116  and  $121,042  which  exceeded  the  FDIC  insurance  limit,  respectively,  of  cash  balances,  including  restricted  cash.  The  Company 
performs ongoing evaluations of these institutions to limit its concentration risk exposure.  

Restricted cash  

The  Company  has  invested  cash  in  a  one  year  restricted  certificate  of  deposit  bearing  interest  at  1%  which  serves  as  collateral  for 
borrowings under a line of credit agreement (see Note 6).  At March 31, 2010 and 2009, the balance in the certificate of deposit was $90,404 and 
$101,053, respectively.  

Customers  

The Company grants credit to customers within the United States of America and to a limited number of international customers and 
does not require collateral. Revenues from international customers are generally secured by advance payments except for a limited number of 
established foreign customers.  The Company generally requires advance or credit card payments for initial revenues from new customers.  The 
Company’s  ability  to  collect  receivables  is  affected  by  economic  fluctuations  in  the  geographic  areas  and  industries  served  by  the 
Company.  Reserves for uncollectible amounts are provided based on past experience and a specific analysis of the accounts which management 
believes are sufficient.  Accounts receivable at March 31, 2010 and 2009 are net of reserves for doubtful accounts of approximately of $1,500 
and $600, respectively. Although the Company expects to collect amounts due, actual collections may differ from the estimated amounts.  

The Company has foreign revenues primarily in Europe, Canada, India and Australia.  During 2010 and 2009, the Company had foreign 

revenues of approximately $66,500 and $6,500, respectively, which constituted approximately 56% and 19% of total revenues, respectively.  

The majority of the Company’s customers are in the biotechnology, pharmaceutical and life science industries. Consequently, there is a 
concentration of receivables within these industries,   which is subject to normal credit risk. At March 31, 2010, annual net revenues from BD 
Biosciences and  CDx Holdings, Inc.  accounted  for  32.1% and 18.7%,  respectively, of  our total revenues.   At March 31,  2009, there  were no 
significant  customer  concentrations.  The  Company  maintains  reserves  for  bad  debt  and  such  losses,  in  the  aggregate,  historically  have  not 

   
   
     
 
    
   
    
   
   
   
 
   
   
   
   
   
   
exceeded our estimates.  

Inventory  

Prior to our new business strategy inventories were stated at the lower of standard cost or current estimated market value.   Cost was 

determined using the standard cost method which approximates the first-in, first-to-expire method.  

Inventories were reviewed periodically for slow-moving or obsolete status. We adjusted our inventory to reflect situations in which the 
cost of inventory was not expected to be recovered. Once established, write-downs of inventories were considered permanent adjustments to the 
cost  basis  of  the  obsolete  or  excess  inventories.  Raw  materials,  work  in  process  and  finished  goods  included  material  costs  less  reserves  for 
obsolete  or  excess  inventories.  We  evaluated  the  current  level  of  inventory  considering  historical  trends  and  other  factors,  and  based  on  our 
evaluation, recorded adjustments to reflect inventory at its net realizable value. These adjustments were estimates, which could vary significantly 
from  actual  results  if  future  economic  conditions,  customer  demand,  competition  or  other  relevant  factors  differ  from  expectations.  These 
estimates required us to make assessments about the future demand for our products in order to categorize the status of such inventory items as 
slow-moving,  obsolete  or  in  excess-of-need.  These  estimates  were  subject  to  the  ongoing  accuracy  of  our  forecasts  of  market  conditions, 
industry trends, competition and other factors. Differences between our estimated reserves and actual inventory adjustments were not significant, 
and were accounted for in the current period as a change in estimate in accordance with generally accepted accounting principles.  

In 2010, the Company changed its operations and now provides shipping containers to its customers and charges a fee in exchange for 
the use of the container.  The Company’s arrangements are similar to the accounting standard for leases since they convey the right to use the 
containers over a period of time.  The Company retains title to the containers and provides its customers the use of the container for a specified 
shipping cycle.  At the culmination of the customer’s shipping cycle, the container is returned to the Company.  As a result, during the quarter 
ended September 30, 2009, the Company reclassified the containers from inventory to fixed assets upon commencement of the per-use container 
program.  

F-9 

 
 
   
   
   
Property and Equipment  

Property  and  equipment  are  recorded  at  cost.  Cryogenic  Shippers  are  depreciated  using  the  straight-line  method  over  their  estimated 
useful lives of three years. Equipment and furniture are depreciated using the straight-line method over their estimated useful lives  (generally 
three to seven years) and leasehold improvements are amortized using the straight-line method over the estimated useful life of the asset or the 
lease term, whichever is shorter. Equipment acquired under capital leases is amortized over the estimated useful life of the assets or term of the 
lease, whichever is shorter and included in depreciation expense.  

Betterments, renewals and extraordinary repairs that extend the lives of the assets are capitalized; other repairs and maintenance charges 
are  expensed  as  incurred.  The  cost  and  related  accumulated  depreciation  and  amortization  applicable  to  assets  retired  are  removed  from  the 
accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets are comprised of patents and trademarks and software development costs.  The Company capitalizes costs of obtaining 
patents  and  trademarks  which  are  amortized,  using  the  straight-line  method  over  their  estimated  useful  life  of  five  years.  The  Company 
capitalizes  certain  costs  related  to  software  developed  for  internal  use.  Software  development  costs  incurred  during  the  preliminary  or 
maintenance project stages are expensed as incurred, while costs incurred during the application development stage are capitalized and amortized 
using the straight-line method over the estimated useful life of the software, which is five years.  Capitalized costs include purchased materials 
and costs of services including the valuation of warrants issued to consultants.  

Long-lived Assets  

If  indicators  of  impairment  exist,  we  assess  the  recoverability  of  the  affected  long-lived  assets  by  determining  whether  the  carrying 
value of such assets can be recovered through undiscounted future operating cash flows. If impairment is indicated, we measure the amount of 
such impairment by comparing the fair value to the carrying value. We believe the future cash flows to be received from the long-lived assets 
will exceed the assets’ carrying value, and accordingly, we have not recognized any impairment losses through March 31, 2010.  

Deferred Financing Costs  

In February, 2010 the Company completed a public offering of units consisting of 1,666,667 shares of common stock and 1,666,667 
warrants  to  purchase  one  share  of  common  stock  at  an  exercise  price  of  $3.30,  for  gross  proceeds  of  $5,000,001  and  net  proceeds  of 
approximately  $3,742,097.  Each  unit  consisting  of  one  share,  together  with  one  warrant  to  purchase  one  share,  was  priced  at  $3.00.  In 
connection with this public offering we incurred financing costs of $1,257,904 which consisted primarily of placement agent fees, accounting, 
legal and filing fees and were netted against the proceeds of the offering upon completion.  

In  connection  with  the  issuance  of  convertible  notes  payable  (see  Note  8),  we  paid  financing  costs,  which  consisted  primarily  of 
placement agent fees, accounting, legal and filing fees and are being amortized over the life of the debt. Amortization of the deferred financing 
costs  using  the  effective  interest  method  was  $159,516  and  $42,284  for  the  years  ended  March 31,  2010  and  2009,  respectively,  and  were 
included in interest expense. As of March 31, 2010 and 2009, deferred financing costs, net of accumulated amortization were approximately $0 
and $3,600, respectively.  

Accrued Warranty Costs  

Estimated costs of the Company’s standard warranty, included with products at no additional cost to the customer for a period up to one 
year,  are  recorded  as  accrued  warranty  costs  at  the  time  of  product  sale.  Costs  related  to  servicing  the  standard  warranty  are  charged  to  the 
accrual as incurred.  

The following represents the activity in the warranty accrual during the years ended March 31:  

Beginning warranty accrual  
Increase in accrual (charged to cost of sales)  
Charges to accrual (product replacements)  
Reversal of remaining accrual due to expected future claims  
Ending warranty accrual  

2010  

2009  

  $ 

  $ 

18,743     $ 
-      
-      
(18,743 )      
-    $ 

29,993   
750   
(12,000 )  
-  
18,743   

   
   
   
   
   
   
   
   
   
   
   
   
   
 
  
  
    
  
  
    
      
  
    
    
    
Convertible Debentures  

If  a  conversion  feature  of  conventional  convertible  debt  is  not  accounted  for  as  a  derivative  instrument  and  provides  for  a  rate  of 
conversion  that  is  below  market  value,  this  feature  is  characterized  as  a  beneficial  conversion  feature  (“BCF”).  A  BCF  is  recorded  by  the 
Company as a debt discount. The convertible debt is recorded net of the discount related to the BCF.  The Company amortizes the discount to 
interest expense over the life of the debt using the effective interest rate method.  

Derivative Liabilities  

Effective April 1, 2009, certain of the Company's issued and outstanding common stock purchase warrants and embedded conversion 
features previously treated as equity pursuant to the derivative treatment exemption were no longer afforded equity treatment, and the fair value 
of these common stock purchase warrants and embedded conversion features, some of which have exercise price reset features and some that 
were issued with convertible debt, were reclassified from equity to liability status as if these warrants were treated as a derivative liability since 
their date of issue.  The common stock purchase warrants were not issued with the intent of effectively hedging any future cash flow, fair value 
of  any  asset,  liability  or  any  net  investment  in  a  foreign  operation.  The  warrants  do  not  qualify  for  hedge  accounting,  and  as  such,  all  future 
changes in the fair value of these warrants are recognized currently in earnings until such time as the warrants are exercised, expire or the related 
rights have been waived. These common stock purchase warrants do not trade in an active securities market, and as such, the Company estimates 
the fair value of these warrants using the Black-Scholes option pricing model (see “Adoption of New Accounting Principle” section below and 
Note 9).  

F-10 

 
 
   
 
   
Commitments and Contingencies  

The Company is subject to routine claims and litigation incidental to our business. In the opinion of management, the resolution of such 

claims is not expected to have a material adverse effect on our operating results or financial position.  

Income Taxes  

The  Company  accounts  for  income  taxes  under  the  provision  of  the  Financial  Accounting  Standards  Board  (“FASB”)  Accounting 
Standards  Codification  (“ASC”)  740,  Income  Taxes,  or  ASC  740.  As  of  March 31,  2010  and  2009,  there  were  no  unrecognized  tax  benefits 
included in the balance sheet that would, if recognized, affect the effective tax rate. Based on the weight of available evidence, the Company's 
Management has determined that it is not more likely than not that the net deferred tax assets assets will be realized. Therefore, the Company has 
recorded a full valuation allowance against the net deferred tax assets. The Company's income tax provision consists of state minimum taxes.  

The Company’s policy is to recognize interest and/or penalties related to income tax matters in income tax expense. The Company had 
no accrual for interest or penalties on its consolidated balance sheets at March 31, 2010 and 2009, respectively and have not recognized interest 
and/or penalties in the consolidated statement of operations for the years ended March 31, 2010 and 2009. The Company is subject to taxation in 
the United States and various state jurisdictions.  As of March 31, 2010, the Company is no longer subject to U.S. federal examinations for years 
before 2006; and for California franchise and income tax examinations for years before 2005.  However, to the extent allowed by law, the taxing 
authorities may have the right to examine prior periods where net operating losses were generated and carried forward, and make adjustments up 
to  the  amount  of  the  net  operating  loss  carry  forward  amount.  The  Company  is  not  currently  under  examination  by  U.S.  federal  or  state 
jurisdictions.  

Supply Concentration Risks  

The  component  parts  for  our  products  are  primarily  manufactured  at  third  party  manufacturing  facilities. The  Company  also  has  a 
warehouse at our corporate offices in Lake Forest, California, where the Company is capable of manufacturing certain parts and fully assemble 
its  products. Most  of  the  components  that  the  Company  uses  in  the  manufacture  of  its  products  are  available  from  more  than  one  qualified 
supplier. For some components, however, there are relatively few alternate sources of supply and the establishment of additional or replacement 
suppliers may not be accomplished immediately, however, the Company has identified alternate qualified suppliers which the Company believes 
could replace existing suppliers. Should this occur, the Company believes that with its current level of shippers and production rate the Company 
has enough to cover a four to six week gap in maximum disruption of production.  

Primary  manufacturers  used  by  us  include  Spaulding  Composites  Company,  Peterson  Spinning  and  Stamping,  Lydall  Industrial 
Thermal Solutions, and Ludwig, Inc. There are no specific agreements with any manufacturer nor are there any long term commitments to any 
manufacturer. The Company believes that any of the manufactures currently used by it could be replaced within a short period of time as none 
have a proprietary component or a substantial capital investment specific to its products.  

Revenue Recognition  

The  Company  provides  shipping  containers  to  their  customers  and  charges  a  fee  in  exchange  for  the  use  of  the  container. The 
Company’  arrangements  are  similar  to  the  accounting  standard  for  leases  since  they  convey  the  right  to  use  the  containers  over  a  period  of 
time. The  Company  retains  title  to  the  containers  and  provides  its  customers  the  use  of  the  container  for  a  specified  shipping  cycle.   At  the 
culmination of the customer’s shipping cycle, the container is returned to the Company.   

The Company recognizes revenue for the use of the shipper at the time of the delivery of the shipper to the end user of the enclosed 

materials, and at the time that collectibility is reasonably certain.  

Accounting for Shipping and Handling Revenue, Fees and Costs  

The Company classifies amounts billed for shipping and handling as revenue. Shipping and handling fees and costs are included in cost 

of sales.  

Research and Development Expenses  

Expenditures  relating  to  research  and  development  are  expensed  in  the  period  incurred.  Research  and  development  expenses  to  date 
have  consisted  primarily of  costs  associated with  the continually improving  the features  of  the  CryoPort Express®  System  including  the  web 
based customer service portal and the CryoPort Express® Shippers. Further, these efforts are expected to lead to the introduction of shippers of 
varying  sizes  based  on  market  requirements,  constructed  of  lower  cost  materials  and  utilizing  high  volume  manufacturing  methods  that  will 

   
   
   
   
   
   
   
   
    
   
   
   
   
     
   
make it practical to provide the cryogenic packages offered by the CryoPort Express® System. Other research and development effort 
has been directed toward improvements to the liquid nitrogen retention system to render it more reliable in the general shipping environment and 
to the design of the outer packaging. Alternative phase change materials in place of liquid nitrogen may be used to increase the potential markets 
these shippers can serve such as ambient and 2-8°C markets.  

Stock-based Compensation  

The Company recognizes compensation expense for all stock-based awards made to employees and directors. The fair value of stock-
based  awards  is  estimated  at  grant  date  using  an  option  pricing  model  and  the  portion  that  is  ultimately  expected  to  vest  is  recognized  as 
compensation cost over the requisite service period.  

Since stock-based compensation is recognized only for those awards that are ultimately expected to vest, the Company has applied an 
estimated forfeiture rate to unvested awards for the purpose of calculating compensation cost. These estimates will be revised, if necessary, in 
future periods  if  actual  forfeitures  differ  from  estimates.  Changes in forfeiture  estimates impact compensation cost  in  the period  in  which  the 
change in estimate occurs. The estimated forfeiture rates at March 31, 2010 and 2009 was zero as the Company has not had a significant history 
of forfeitures and does not expect forfeitures in the future.  

The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock-based awards. The determination of fair 
value  using  the  Black-Scholes  option-pricing  model  is  affected  by its  stock  price  as  well  as assumptions  regarding  a number  of  complex  and 
subjective  variables,  including  expected  stock  price  volatility,  risk-free  interest  rate,  expected  dividends  and  projected  employee  stock  option 
exercise behaviors.  

At March 31, 2010, there was $471,401 of total unrecognized compensation cost related to non-vested stock options, which is expected 

to be recognized over a remaining weighted average vesting period of approximately 1.69 years.  

The Company’s stock-based compensation plans are discussed further in Note 11.  

F-11 

 
   
   
   
   
   
   
Issuance of Stock for Non-Cash Consideration  

The Company accounts for equity issuances to non-employees in accordance with accounting guidance for equity instruments that are 
issued to other than employees for acquiring, or in conjunction with selling, goods and services. All transactions in which goods or services are 
the consideration received for the issuance of equity instruments are accounted for based on the fair value of the consideration received or the 
fair value of the equity instrument issued, whichever is more reliably measurable. The measurement date used to determine the fair value of the 
equity  instrument  issued  is  the  earlier  of  the  date  on  which  the  third-party  performance  is  complete  or  the  date  on  which  it  is  probable  that 
performance will occur.  

Basic and Diluted Loss Per Share  

Basic loss per common share is computed based on the weighted average number of shares outstanding during the period.  Diluted loss 
per  share  is  computed  by  dividing  net  loss  by  the  weighted  average  shares  outstanding  assuming  all  dilutive  potential  common  shares  were 
issued.  For the years ended March 31, 2010 and 2009, the Company was in a loss position and the basic and diluted loss per share are the same 
since the effect of stock options, warrants and convertible notes payable on loss per share was anti-dilutive and thus not included in the diluted 
loss  per  share calculation.  The  impact  under the  treasury  stock  method  of  dilutive stock  options  and warrants  and  the if-converted method  of 
convertible debt would have resulted in weighted average common shares outstanding of 8,472,977 and 5,756,525 for the years ended March 31, 
2010 and 2009, respectively.  

In  addition,  in  computing  the  dilutive  effect  of  convertible  securities,  the  numerator  is  adjusted  to  add  back  the  after-tax  amount  of 

interest, if any, recognized in the period associated with any convertible debt.  

Segment Reporting  

We currently operate in only one segment.  

F-12 

   
   
 
   
   
   
    
    
Adoption of New Accounting Principle  

Equity-linked instruments (or embedded features) that otherwise meet the definition of a derivative are not accounted for as derivatives 
if certain criteria are met, one of which is that the instrument (or embedded feature) must be indexed to the entity’s own stock. The Company’s 
warrant  and  convertible  debt  agreements  contain  adjustment  (or  ratchet)  provisions and  accordingly,  the  Company  determined  that  these 
instruments are not indexed to the Company’s common stock.  As a result of the adoption of new accounting guidance, the Company is required 
to account for these instruments as derivative liabilities. The Company applied these provisions to outstanding instruments as of April 1, 2009. 
The cumulative effect at April 1, 2009  was to record, at fair value, a liability for the warrants and embedded conversion features, including the 
effects  on  the  discounts  on  the  convertible  notes of  $2,595,095,  resulted  in  an aggregate  reduction to  equity  of $13,875,623  consisting  of a 
reduction  to  additional  paid-in  capital  of  $4,217,730  and  an  increase  in  the  accumulated  deficit  of  $9,657,893  to  reflect  the  change  in  the 
accounting.  The warrants and embedded conversion features are carried at fair value and adjusted each period through earnings.  

During  February  2010,  the  Company  reclassified  $9,009,329  in  derivatives  liabilities  to  additional  paid-in  capital  due  to  the 

modification in terms resulting from the 2010 Amendment, as defined (see Note 9).  

The following table summarizes the effect of the adoption of the accounting principle on the consolidated balance sheet as of April 1, 

2009:  

Liabilities and Stockholders’ Deficit:  

Total liabilities  

Stockholders’ deficit:  
Common stock  
Additional paid-in capital  
Accumulated deficit  
Total stockholders’ deficit  

Total liabilities and stockholders’ deficit  

F-13 

As  
Previously  
Reported  

     As Adjusted  

Cumulative  
Adjustment  

  $ 

6,348,460     $ 

20,224,083     $ 

13,875,623   

4,186       
25,854,265       
(30,634,355 )     
(4,775,904 )      
1,572,556     $ 

4,186       
21,636,535       
(40,292,248 )     
(18,651,527 )      
1,572,556     $ 

—  
(4,217,730 ) 
(9,657,893 ) 
(13,875,623 )  
—  

  $ 

 
   
   
   
   
   
  
  
    
  
    
      
      
  
      
        
        
  
    
    
    
    
CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

New Accounting Pronouncements  

In  August  2010, the  FASB  issued  Accounting Standards  Update (“ASU”)  No. 2010-05, Measuring  Liabilities  at  Fair  Value,  or ASU 
2010-05, which amends ASC 820 to provide clarification of a circumstance in which a quoted price in an active market for an identical liability 
is not available. A reporting entity is required to measure fair value using one or more of the following methods: 1) a valuation technique that 
uses  a)  the  quoted  price  of  the  identical  liability  when  traded  as  an  asset  or  b)  quoted  prices  for  similar  liabilities  (or  similar  liabilities  when 
traded  as  assets)  and/or  2)  a  valuation  technique  that  is  consistent  with  the  principles  of  ASC  820.  ASU  2010-05  also  clarifies  that  when 
estimating the fair value of a liability, a reporting entity is not required to adjust to include inputs relating to the existence of transfer restrictions 
on that liability. The adoption did not have a material impact on our consolidated financial statements.  

Note 2.  Inventory  

Inventories consist of the following:  

Raw materials  
Work in process  
Finished goods  

   March 31,  

      March 31,  

2010  

2009  

  $ 

  $ 

—    $ 
—      
—      
—    $ 

350,021   
7,253   
172,967   
530,241   

During its early years, the Company's limited revenue was derived from the sale of our reusable product line. The Company's current 
business plan focuses on per-use leasing of shipping containers and value-added services that will be used by us to provide an end-to-end and 
cost-optimized shipping solutions.  

The Company provides shipping containers to its customers and charges a fee in exchange for the use of the container.  The Company’s 
arrangements  are  similar  to  the  accounting  standard  for  leases  since  they  convey  the  right  to  use  the  containers  over  a  period  of  time.   The 
Company retains title to the containers and provides its customers the use of the container for a specified shipping cycle.  At the culmination of 
the  customer’s  shipping  cycle,  the  container  is  returned  to  the  Company.   As  a  result,  during  the  quarter  ended  September  30,  2009,  the 
Company reclassified its containers from inventory to property and equipment upon commencement of the per-use leasing program.  

Note 3.  Property and Equipment  

Equipment and leasehold improvements and related accumulated depreciation and amortization are as follows:  

Cryogenic shippers  
Furniture and fixtures  
Machinery and equipment  
Leasehold improvements  

Less accumulated depreciation and amortization  

March 31,  

2010  

2009  

449,734      $ 
3,284        
340,169        
19,426        

812,613        
(253,372 )      
559,241      $ 

-  
23,253   
640,748   
19,426   

683,427   
(494,126 ) 
189,301   

  $ 

  $ 

During its early years, the Company's limited revenue was derived from the sale of our reusable product line.  The Company's current 
business plan focuses on per-use leasing of shipping containers and added-value services that will be used by us to provide an end-to-end and 
cost-optimized shipping solutions.  

Total depreciation and amortization expense related to property and equipment amounted to $80,746 and $63,129 for the years ended 

March 31, 2010 and 2009, respectively.  

   
   
   
   
   
 
   
   
    
   
   
   
   
   
  
  
  
  
     
  
  
    
     
    
    
    
  
  
  
  
  
  
    
  
    
    
    
  
    
        
    
  
    
    
  
F-14 

Note 4.  Intangible Assets  

Intangible  assets  are  comprised  of  patents  and  trademarks  and  software  developed  for  internal  uses.  The  gross  book  values  and 

accumulated amortization as of March 31, 2010 and 2009 were as follows:  

Patents and trademarks  
Software development costs  

Less accumulated amortization  

2010  

2009  

  $  

91,354     $  
355,081       
446,435       
(134,470 )     

47,375   
282,112   
329,487   
(65,123 ) 

  $  

311,965     $  

264,364   

Amortization expense for intangible assets for the years ended March 31, 2010 and 2009 was $69,347 and $18,855, respectively. All of 

the Company’s intangible assets are subject to amortization.  

Estimated future annual amortization expense pursuant to these intangible assets is as follows:  

Years Ending March 31,  

2011  
2012  
2013  
2014  
2015  
Thereafter  

Patents and 
Trademarks       

Software  

Total  
Intangibles  

  $  

5,088     $  
5,088       
5,088       
5,061       
1,636       
19,607       

70,993     $  
70,993       
70,993       
52,306       
5,112       
-       

76,081   
76,081   
76,081   
57,367   
6,748   
19,607   

  $  

41,568     $  

270,397     $  

311,965   

F-15 

 
 
 
 
 
   
   
  
  
    
  
  
    
        
    
    
  
    
    
  
    
        
    
  
  
    
  
  
    
        
        
    
    
    
    
    
    
  
    
        
        
    
  
CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 5.  Fair Value Measurements  

The Company determines the fair value of its derivative instruments using a three-level hierarchy for fair value measurements which 
these assets and liabilities must be grouped, based on significant levels of observable or unobservable inputs. Observable inputs reflect market 
data obtained from independent sources, while unobservable inputs reflect the Company’s market assumptions. This hierarchy requires the use 
of observable market data when available. These two types of inputs have created the following fair-value hierarchy:  

Level 1 — Valuations based on unadjusted quoted market prices in active markets for identical securities. Currently the Company does 

not have any items classified as Level 1.  

Level  2  —  Valuations  based  on  observable  inputs  (other  than  Level  1  prices),  such  as  quoted  prices  for  similar  assets  at  the 
measurement date; quoted prices in markets that are not active; or other inputs that are observable, either directly or indirectly.  The Company 
classifies its restricted cash balance as a Level 2 item. At March 31, 2010 and 2009 the balance in the restricted cash account was $90,404 and 
$101,053, respectively.  

Level  3  —  Valuations  based  on  inputs  that  are  unobservable  and  significant  to  the  overall  fair  value  measurement,  and  involve 
management judgment. The Company uses the Black-Scholes option pricing model to determine the fair value of the instruments.  If the inputs 
used to measure fair value fall in different levels of the fair value hierarchy, a financial security’s hierarchy level is based upon the lowest level 
of input that is significant to the fair value measurement.  

The following table presents the Company’s warrants and embedded conversion features measured at fair value on a recurring basis as 

of March 31, 2010 and April 1, 2009 (the Company’s adoption date of derivative liability accounting) classified using the valuation hierarchy:  

Embedded Conversion Option  
Warrants  

Level 3  

Level 3  

   Carrying Value       Carrying Value    
   March 31, 2010       April 1, 2009     

  $ 

  $ 

—    $ 
334,363       
334,363     $ 

3,900,134   
12,570,584   
16,470,718   

The following table provides a reconciliation of the beginning and ending balances for the Company’s derivative liabilities measured at 

fair value using Level 3 inputs:  

Balance at April 1, 2009  
Cumulative effect of change in accounting principle  
Derivative liability added –  warrants  
Derivative liability added – conversion option  
Reclassification of conversion feature to equity upon conversions of notes  
Reclassification of conversion feature and warrants to equity upon modification of terms (no longer derivative instruments)       
Change in fair value, net  
Balance at March 31, 2010  

  $ 

  $ 

—  
16,470,718   
389,781   
788,631   
(2,728,459)   
(9,009,329)   
(5,576,979)    
334,363   

F-16 

   
   
    
   
   
   
   
   
   
    
    
   
  
  
    
  
  
  
  
    
      
  
    
  
    
    
    
    
    
CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 6.  Line of Credit  

On  November  5,  2007,  the  Company  secured  financing  for  a  $200,000  one-year  revolving  line  of  credit  (the  “Line”)  secured  by  a 
$200,000  Certificate  of  Deposit  with  Bank  of  the  West.  On  November  6,  2008,  the  Company  secured  a  one-year  renewal  of  the  Line  for  a 
reduced amount of $100,000 which is secured by a $100,000 Certificate of Deposit with Bank of the West. On October 19, 2009, the Company 
secured a one-year renewal of the Line for a reduced amount of $90,000 which is secured by a $90,000 Certificate of Deposit with Bank of the 
West. All borrowings under the revolving line of credit bear variable interest based either the prime rate plus 1.5% per annum (totaling 4.75% as 
of March 31, 2010) or 5.0%, whichever is higher. The Company utilizes the funds advanced from the Line for capital equipment purchases to 
support  the  commercialization  of  the  Company’s  CryoPort  Express®  One-Way  Shipper.  As  of  March  31,  2010  and  2009,  the  outstanding 
balance of the Line was $90,388 and $90,310, including accrued interest of $388 and $310, respectively.  No funds were drawn against the Line 
during the years ended March 31, 2010 or 2009.  The Company recorded interest expense of $4,094 and $3,099 for the years ended March 31, 
2010 and 2009, respectively.  

Note 7.  Related Party Transactions  

Related Party Notes Payable  

As  of  March  31,  2010  and  2009,  the  Company  had  aggregate  principal  balances  of  $1,009,500  and  $1,129,500,  respectively,  in 
outstanding unsecured indebtedness owed to five related parties, including four former members of the board of directors, representing working 
capital  advances  made  to  the  Company  from  February  2001  through  March  2005.  These  notes  bear  interest  at  the  rate of  6%  per  annum  and 
provide for aggregate monthly principal payments which began April 1, 2006 of $2,500, and which increased by an aggregate of $2,500 every 
nine months to a maximum of $10,000 per month.  As of March 31, 2010, the aggregate principal payments totaled $10,000 per month.  Any 
remaining unpaid principal and accrued interest is due at maturity on various dates through March 1, 2015.  

Related-party  interest  expense  under  these  notes  was  $64,496  and  $71,676  for  the  years  ended  March  31,  2010  and  2009, 
respectively.  Accrued interest related to these notes, which is included in related party notes payable in the accompanying consolidated balance 
sheets, amounted to $618,756 and $554,260 as of March 31, 2010 and 2009, respectively. As of March 31, 2010, the Company had not made the 
required payments under the related-party notes which were due on January 1, February 1, and March 1, 2010.  However, pursuant to the note 
agreements, the Company has a 120-day grace period to pay missed payments before the notes are in default. On April 15, 2010,  May 16, 2010 
and June 14, 2010 the Company paid the January 1, 2010, February 1, 2010 and the March 1, 2010  note  payments due on these related party 
notes, respectively. Management expects to continue to pay all payments due prior to the expiration of the 120-day grace periods.  

Scheduled maturities of related party debt as of March 31, 2010 are as follows:  

Years Ending March 31:  
2011  
2012  
2013  
2014  
2015  
Thereafter  

Note Payable to Former Officer  

   $ 

150,000    
104,000    
96,000    
96,000    
96,000   
467,500    

   $ 

1,009,500    

In August 2006, Peter Berry, the Company’s former Chief Executive Officer, agreed to convert his deferred salaries to a long-term note 
payable. Under the terms of this note, the Company began to make monthly payments of $3,000 to Mr. Berry in January 2007. The loan was 
fully paid in March 2010. Interest of 6% per annum on the outstanding principal balance of the note began to accrue on January 1, 2008.  As of 
March 31, 2010 and 2009, the total amount of the note and accrued interest under this arrangement was $0 and $157,688, respectively, of which, 
$0 and $67,688, respectively, is recorded as a long-term liability in the accompanying consolidated balance sheets.  Mr. Berry agreed to a final 
settlement of $143,950 resulting in a reversal of interest expense recognized in prior years of $11,821.  Interest expense related to this note was 
$8,133 and $10,573 for the years ended March 31, 2010 and 2009, respectively. Accrued interest related to this note payable amounted to $0 and 

   
   
   
 
 
 
 
   
   
   
   
   
     
  
     
     
     
    
     
  
         
  
  
$13,738  at  March  31,  2010  and  2009,  respectively,  and  is  included  in  the  note  payable  to  former  officer  in  the  accompanying 
consolidated balance sheets. In January 2009, Mr. Berry agreed to defer the monthly payments of the note due from January 31, 2009 through 
June  30,  2009.  Effective  August  26,  2009,  pursuant  to  a  letter  agreement  (i)  the  Company  agreed  to  pay  Mr.  Berry  the  sum  of  $30,000  plus 
accrued  interest  representing  past  due  payments  from  January  to  May  2009  previously  waived  by  Mr.  Berry,  (ii)  Mr.  Berry  agreed  to  waive 
payments due to him through December 2009, and (iii) the Company agreed to pay to Mr. Berry  the sum of $42,000 plus accrued interest on 
January 1, 2010, representing payments due to him from June 2009 thru December 2009. As of March 31, 2010 and 2009 these unpaid payments 
totaled  $0  and  $18,000,  respectively,  and  are  included  in  the  current  liability  portion  of  the  note  payable  in  the  accompanying  consolidated 
balance  sheets.  In  February  2009,  Mr.  Berry  resigned  his  position  as  Chief  Executive  Officer  and  on  July  30,  2009.  Mr.  Berry  resigned  his 
position from the Board.  

Consulting agreement with Former Officer  

On  March  1,  2009,  the  Company  entered  into  a  Consulting  Agreement  with  Peter  Berry,  the  Company’s  former  Chief  Executive 
Officer.  Mr.  Berry  provided  the  Company  with  consulting  services  as  an  independent  contractor,  for  a  ten  (10)  month  period  from  March  1, 
2009 through December 31, 2009, as an advisor to the Chief Executive Officer and the Board of Directors.  

Related-party consulting fees for these services were $292,010 for the year ended March 31, 2010.  

F-17 

 
   
   
   
Related party legal services  

Since June 2005, the Company had retained the legal services of Gary C. Cannon, Attorney at Law, for a monthly retainer fee.  From 
June 2005 to May 2009, Mr. Cannon also served as the Company’s Secretary and a member of the Company’s Board of Directors.  Mr. Cannon 
continued  to  serve  as  Corporate  Legal  Counsel  for  the  Company  and  served  as  a  member  of  the  Advisory  Board.  In  December  2007,  Mr. 
Cannon’s monthly retainer for legal services was increased from $6,500 per month to $9,000 per month.  The total amount paid to Mr. Cannon 
for retainer fees and out-of-pocket expenses for the year ended March 31, 2010 and 2009 was $34,350 and $81,000, respectively.  From October 
2008 through March 31, 2009 Mr. Cannon agreed to defer a portion of his monthly payments.  As of March 31, 2010 and March 31, 2009 a total 
of  $0  and  $15,000,  respectively,  had  been  deferred  and  was  included  in  accounts  payable  in  the  accompanying  consolidated  balance  sheets. 
Board fees expensed for Mr. Cannon were $5,388 and $26,850 for the years ended March 31, 2010 and March 31, 2009, respectively. At March 
31,  2010  and  March  31,  2009,  $7,788  and  $14,400,  respectively,  of  deferred  board  fees  was  included  in  accrued  compensation  and  related 
expenses.  During the year ended March 31, 2010, Mr. Cannon was granted a total of  2,557 warrants with an average exercise price of $5.90 per 
share.  For the year ended March 31, 2009, Mr. Cannon was granted a total of 9,515 warrants with an average exercise price of $6.70 per share. 
All warrants granted to Mr. Cannon were issued with an exercise price of greater than or equal to the stock price of the Company’s shares on the 
grant  date. On  May  4, 2009,  Mr.  Cannon resigned  from  the  Company’s Board  of  Directors  and  in July  2009 Mr. Cannon  was  given  30  days 
notice that he was terminated as the general legal counsel and advisor to the Company.  

Consulting agreement with Officer  

On  July  29,  2009,  the  Board  of  Directors  of  the  Company  appointed  Ms.  Catherine  M.  Doll,  a  consultant,  to  the  offices  of  Chief 

Financial Officer, Treasurer and Assistant Corporate Secretary, which became effective on August 20, 2009.  

Ms. Doll, is the owner and chief executive officer of The Gilson Group, LLC.  The Gilson Group, LLC provided the Company financial 
and accounting consulting services including, SEC and financial reporting including the filing of the S-1, budgeting and forecasting and finance 
and accounting systems implementations and conversions.    

Related-party  consulting  fees  for  these  services  were  $234,650  for  the  year  ended  March  31,  2010.  On  October 9,  2009,  the 
Compensation and Governance Committee granted Ms. Doll an option to purchase 2,000 shares of common stock at an exercise price of $4.50 
per share (the closing price of the Company’s stock on the date of grant) valued at $8,480 as calculated using the Black Scholes option pricing 
model and is included in selling, general and administrative expense. The assumptions used under the Black-Scholes pricing model included: a 
risk free rate of 2.36%; volatility of 182%; an expected exercise term of 4.25 years; and no annual dividend rate. The right to exercise the stock 
options  vested  as  to  33 1/3%  of  the  underlying  shares  of  common  stock  upon  grant,  with  the  remaining  underlying  shares  vesting  in  equal 
installments on the first and second anniversary of the grant date.  

Note 8.  Convertible Notes Payable  

The Company’s convertible debenture balances are shown below:  

October 2007 Debentures  
May 2008 Debentures  
Private Placement Debentures  
Accrued interest on convertible debentures  

Debt discount   
Total convertible debentures and notes payable, net  

March 31,  
2010  
3,150,975     $ 
79,593       
—      
—      
3,230,568       
(728,109)       
2,502,459     $ 

March 31,  
2009  
5,356,073   
1,325,556   
60,000   
44,544   
6,786,173   
(2,903,374)   
3,882,799   

  $ 

  $ 

Short-term:  
Convertible notes payable, net of discount of $13,586 in 2009  
Current portion of convertible debentures payable and accrued interest, net of discount of  $662,583  in 
2009  
Long-term:  
Convertible debentures payable, net of current portion and discount of $728,109 in 2010 and $2,227,205 
in 2009, respectively  
Total convertible debentures and notes payable, net  

  $ 

  $ 

—    $ 

46,414   

200,000       

3,836,385   

2,302,459       
2,502,459     $ 

—  
3,882,799   

 
 
 
 
   
   
 
 
 
   
  
  
    
  
    
    
    
  
    
    
  
      
        
  
      
        
  
    
      
        
  
    
During  the  years  ended  March  31,  2010  and  2009,  the  Company  recognized  an  aggregate  of  $6,417,346  and  $2,223,116  in  interest 
expense,  respectively,  due  to  amortization  of  debt  discount  related  to  the  warrants  and  embedded  conversion  features  associated  with  the 
Company’s outstanding convertible debentures and convertible notes payable.  As of March 31, 2010, the principal amount of $3,230,568 of the 
Company’s convertible notes payable was convertible into 1,076,856 shares of the Company’s common stock.  

October 2007 and May 2008 Debentures  

The  Company  issued  convertible  debentures  in  October  2007  (the  “October  2007  Debentures”)  and  in  May  2008  (the  “May  2008 
Debentures,” and together with the October 2007 Debentures, the “Debentures”). The Debentures were issued to four institutional investors and 
have an outstanding principal balance of $3,230,568 as of March 31, 2010.  In addition, in October 2007 and May 2008, the Company issued to 
these institutional investors warrants to purchase, as of March 31, 2010, an aggregate of 3,055,097 shares of the Company’s common stock (the 
“Debenture Warrants”).  As collateral to secure our repayment obligations to the holders of the Debentures we have granted such holders a first 
priority security interest in generally all of our assets, including our intellectual property.  

Fiscal Year 2009 Activity  

During the year ended March 31, 2009, the Company incurred a loss on extinguishment of debt of $6,902,941 due to the April 30, 2008 
Amendment of the October 2007 Debentures (the “April Amendment”).  The April Amendment provided for a nine month deferral of principal 
payments, an increase in the number of shares to be purchased under each of the October 2007 Warrants and a decrease in the Exercise Price 
of  the October 2007 Warrants from $9.00, $9.20 and $16.00 to $6.00 each.  In addition, the Company eliminated the unamortized balance of 
deferred financing costs related to the October 2007 Debentures.  

F-18 

 
 
 
 
   
On August 29, 2008, the Company entered into an “Amendment to Debentures, Agreement and Waiver” (the “August Amendment”) 
with the holders of the October 2007 Debentures. The August Amendment waived quarterly interest payments that would otherwise have been 
due  on  October  1,  2008  and  January  1,  2009  and  deferred  the  monthly  redemption  dates  from  July  31,  2008  through  November  30,  2008  to 
commence upon December 31, 2008, and were to terminate upon full redemption of the October 2007 Debentures. In consideration for entering 
into the August Amendment, the outstanding principal amount of the October 2007 Debentures was increased to an amount equal to 115% of the 
sum  of  (i)  the  outstanding  principal  amount  of  as  of  August  29,  2008,  the  date  of  the  August  Amendment,  plus  (ii)  an  amount  equal  to  the 
additional  amount  of  interest  that  would  have  accrued  on  the  October  2007  Debenture  from  July  1,  2008  through  December  31,  2008.  The 
August Amendment was accounted for as an extinguishment of debt and the Company recorded the amended October 2007 Debentures at their 
then fair value of $2,203,086 at the date of extinguishment.  The difference between the fair value of the amended October 2007 Debentures and 
the carrying value of the original October 2007 Debentures at the date of debt extinguishment, which amounted to $91,728, was recorded as an 
offset against the loss on debt extinguishment for the year ended March 31, 2009.  

During the year ended March 31, 2009, the Company incurred a loss on extinguishment of debt of $4,035,360 as a result of the January 
27,  2009  Amendment  of  the  Debentures  (the  “January  Amendment”).  The  Debentures  were  amended  to  reflect  changes  to  the  monthly 
redemptions of principal, the quarterly payments of interest and changes to the Debenture Warrants related to the original October 2007 and May 
2008 Debentures.  Under the terms of the January Amendment, the conversion price of the debentures was reset from $8.40 to $5.10, monthly 
principal redemptions were deferred until August 1, 2009 and the remaining principal due on each of the debentures was to be paid thereafter on 
the first date of each month in twelve equal installments through July 1, 2010, the amended maturity date.  During the deferral period interest 
payments due from January 1, 2009 through July 1, 2009 could be paid monthly by the Company in common stock shares at a conversion rate of 
$4.00 if the Company had met certain equity conditions prior to the due date of the interest payments.  If the equity conditions were not met, the 
Company added the monthly interest payments to the principal balance of the Debentures.  

Further, the January Amendment reset the exercise price of the May 2008 Debenture Warrants from the then current exercise prices of 
$6.00,  $9.20  and  $13.50  per  share  to  $6.00  per  share  and  extended  the  expiration  dates  of  both  the  October  2007  and  May  2008  Debenture 
Warrants to January 1, 2014. The number of shares to be purchased under the Debenture Warrants was proportionately increased under the terms 
of  the  amendments  so  that  the  original  dollar  amounts  to  be  raised  by  the  Company  through  the  exercise  of  each  of  the  warrants  and  the 
proportional number of warrants issued to each Debenture Holder remained the same.  As a result, the number of shares of common stock to be 
purchased  under  the  October  2007  Warrants  increased  by 285,190  to 1,728,326  and  the  number  of  shares  of  common  stock  to  be  purchased 
under the May 2008 Warrants increased by 265,577 to 562,996.  Under the terms of the January Amendment, in February 2009, the Company 
issued a total  of  40,000 restricted  common  shares  valued  at $164,000 to  the holders of  the  Debentures,  which  shares  were  accounted for as a 
payment  to  the  debt  holders  in  connection  with  the  debt  extinguishment  and  included  in  the  loss  on  debt  extinguishment  for  the  year  ended 
March 31, 2009.  

Fiscal Year 2010 Activity  

During the year ended March 31, 2010, the Company converted interest payments due on the Debentures totaling $171,253 into 42,814 

shares of common stock using the conversion rate of $4.00.  

In May 2009, approximately $713,000 of the October 2007 Debentures was converted by a note holder.  Using the conversion rate of 
$5.10  per  share  per  the  terms  of  the  debenture,  139,804  shares  of  common  stock  were  issued  to  the  investor.  In  addition,  the  fair  value  of 
$593,303 related to the conversion feature was reclassed from the liability for derivative instruments to additional paid-in capital (see Note 10) 
and accelerated the recognition of $508,886 of unamortized debt discount as interest expense.  

On  July  30,  2009,  the  Company  entered  into  a  Consent,  Waiver  and  Agreement  with  the  holders  of  the  Debentures  (the  “July 
Agreement”). Pursuant  to  the  terms  of  the  July  Agreement,  the  Holders  (i)  consented  to  the  Company’s  issuance  of  convertible  notes  and 
warrants in connection with a bridge financing of up to $1,500,000 which commenced in March 2009 (the “Bridge Financing”), and (ii) waived, 
as it relates to the Bridge Financing, a covenant contained in the Debentures not to incur any further indebtedness, except as otherwise permitted 
by the Debentures.  This Bridge Financing is more particularly described below under the caption “Private Placement Debentures.”  In addition, 
in  connection  with  the  July  Agreement,  the  Company  and  Holders  confirmed  that  (i)  the  exercise  price  of  the  Debenture  Warrants  had  been 
reduced,  pursuant  to  the  terms  of  the  Debenture  Warrants,  to  $5.10  as  a  result  of  the  Bridge  Financing,  and  (ii)  as  a  result  of  the  foregoing 
decrease in the exercise price, pursuant to the terms of the Debenture Warrants, the number of shares underlying the Debenture Warrants held by 
Holders  of  the  Debentures  had  been  proportionally  increased  by  404,350  pursuant  to  the  terms  of  the  warrant  agreements.  As  a  result  of  the 
foregoing adjustments, the Company recognized a loss in other expense due to the change in fair value of derivative liabilities of $1,608,540 and 
a corresponding increase to the liability for derivative instruments.  

On  September  17,  2009,  the  Company  entered  into  an  Amendment  to  Debentures  and  Warrants,  Agreement  and  Waiver  (the 
“September Amendment”) with the holders of the Company’s outstanding Debentures and associated Debenture Warrants to purchase common 
stock,  as  such  Debentures  and  Debenture  Warrants  have  been  amended.  The  effective  date  of  the  September  Amendment  was  September  1, 

   
   
   
     
    
 
 
   
2009.  The purpose of the September Amendment was to restructure the Company’s obligations  under the  outstanding Debentures in 
order to reduce the amount of the required monthly principal payment and temporarily defer the commencement of monthly principal payments 
(which  was  scheduled  to  commence  September  1,  2009)  and  ceased  the  continuing  interest  payments  for  a  period  time.  The  following  is  a 
summary of the material terms of the September Amendment:  

1.   
   The  Company  was  required  to  obtain  stockholder  approval  of  an  amendment  to  its  Amended  and  Restated  Articles  of 
Incorporation  to  increase  the  number  of  authorized  shares  of  its  common  stock  to  250,000,000.  Such  approval  was  obtained  at  the 
shareholders’ meeting on October 9, 2009, and an amendment was filed with the Nevada Secretary of State on November 2, 2009.  

2.   
   As  of  September  1,  2009,  the  principal  amount  of  the  Debentures  was  increased  by  $482,792,  which  was  added  to  the 
outstanding  principal  balances  and  $403,214  was  recorded  as  a  debt  discount  and  will  be  amortized  over  the  remaining  life  of  the 
Debentures. The  increase  reflected  all  accrued  and  unpaid  interest  as  of  such  date,  plus  all  interest  that  would  have  accrued  on  the 
principal amount (as increased as of September 1, 2009, to reflect the then accrued but unpaid interest) from September 1, 2009, to July 
1,  2010  (the  maturity  date  of  the  Debentures).  The  Company  had  no  obligation  under  the  Debentures  to  make  further  payments  of 
interest, and interest ceased to accrue, during the period September 1, 2009 to July 1, 2010.  

   The  conversion  price  of  the  Debentures  was  decreased  from  $5.10  per  share  to  $4.50  per  share,  which  resulted  in  an 
3.   
increase in the number shares of common stock which the Debentures may be converted into, an increase in the liability for derivative 
instruments of $802,200 and a corresponding loss was recorded in other expense, net due to the change in fair value of derivatives.  

  The commencement of the Company’s obligation to make monthly payments of principal was deferred from September 1, 
4.  
2009, to January 1, 2010, at which time the Company was to make monthly pro rata payments to the Holders in the aggregate amount of 
$200,000 with a balloon payment due on the maturity date of July 1, 2010.  Prior to the Amendment, the Company was obligated to 
repay  the  entire  outstanding  principal  amount  of  the  debentures  in  twelve  equal  monthly  payments  commencing  on  August  1, 
2009.    On January 12, 2010, the Company entered into an Amendment to Debentures and Warrants, Agreement and Waiver with the 
Holders of the Company Debentures, which was subsequently amended in February 2010, as discussed below).  

5.  
fully diluted ownership of 34.5%.  

  The Holders’ existing right to maintain a fully diluted ownership equal to 31.5% has been increased by the Amendment to a 

F-19 

 
 
 
   
 
 
   
 
 
   
 
 
   
 
 
   
6.  
  The exercise price of the outstanding Debenture Warrants was decreased from $5.10 per share to $4.50 per share, which 
also  resulted  in  a  corresponding  pro  rata  increase  in  the  number  of  shares  that  would  be  purchased  upon  exercise  of  the  Debenture 
Warrants to  an aggregate of  3,055,095 shares.  The  reduction  in exercise price of  the  Debenture  Warrants  to $4.50 per share  and the 
359,423  share  increase  in  the  number  of  Debenture  Warrants  resulted  in  an  increase  in  the  liability  for  derivative  instruments  of 
$1,679,990 and a corresponding loss was recorded in other expense, net due to the change in fair value of derivative liabilities.  

7.           The following additional covenants were added to the Debentures (replacing similar covenants which had terminated as of June 
30, 2009) and remained in full force so long as any of the Debentures remain outstanding (the “Covenant Period”):  

a.           The Company was to maintain a total cash balance of no less than $100,000 at all times during the Covenant Period;  

b.           The Company was to have an average monthly operating cash burn of no more than $500,000 during the Covenant 
Period. Operating cash burn was defined by taking net income (or loss), added back all non-cash items, and excluded changes 
in assets, liabilities and financing activities;  

c.           The  Company  was  to  have  a  minimum  current  ratio  of  0.5  to  1  at  all  times  during  the  Covenant  Period.  This 
calculation was to be made by excluding the current portion of the convertible notes payable and accrued interest, and liability 
from derivative instruments from current liability for the current ratio;  

d.           Accounts payable was not to exceed $750,000 at any time during the Covenant Period;  

e.           Accrued salaries was not to exceed $350,000 at any time during the Covenant Period; and  

f.           The Company was not make any revisions to the terms of the existing contractual agreements for the Notes Payable to 
Former Officer, Related Party Notes Payable and the Line of Credit (as each is referred to in the Company’s Form 10-Q for the 
period  ended June  30, 2009); other  than the previous  amendment to  the  payment terms  of  a  note payable to the  Company’s 
former CEO.  

   The  Company  was  not  to  deliver  a  redemption  notice  with  respect  to  the  outstanding  Debentures  until  such  time  as  the 
8.   
closing price of the Company’s common stock shall have exceeded $7.00 (as adjusted for stock splits or similar transactions) for ten 
consecutive trading days prior to the delivery of the redemption notice.  

On  September  22,  2009,  the  holders  of  the  October  2007  Debentures  converted  $100,000  of  principal  into  22,222  shares  of  the 
Company’s  common  stock  at  a  conversion  price  of  $4.50.  As  a  result  of  the  conversion,  the  Company  reclassified  $52,799  of  the  derivative 
liability related to the embedded conversion feature to additional paid in capital and accelerated the recognition of $41,277 of unamortized debt 
discount as interest expense.  

On  October  9,  2009,  the  holders  of  the  October  2007  Debentures  converted  $90,000  principal  into  20,000  shares  of  the  Company’s 
common stock at a conversion price of $4.50.  As a result of the conversion, the Company reclassified $37,001 of the derivative liability related 
to  the  embedded  conversion  feature  to  additional  paid  in  capital  and  accelerated  the  recognition  of  $33,708  of  unamortized  debt  discount  as 
interest expense.  

On November 17, 2009, the holders of the October 2007 Debentures converted $180,000 principal into 40,000 shares of the Company’s 
common stock at a conversion price of $4.50.  As a result of the conversion, the Company reclassified $80,368 of the derivative liability related 
to  the  embedded  conversion  feature  to  additional  paid  in  capital  and  accelerated  the  recognition  of  $59,262  of  unamortized  debt  discount  as 
interest expense.  

On November 24, 2009, the holders of the October 2007 Debentures converted $100,000 principal into 22,222 shares of the Company’s 
common stock at a conversion price of $4.50.  As a result of the conversion, the Company reclassified $38,224 of the derivative liability related 
to  the  embedded  conversion  feature  to  additional  paid  in  capital  and  accelerated  the  recognition  of  $32,034  of  unamortized  debt  discount  as 
interest expense.  

On January 11, 2010, the holders of the October 2007 Debentures converted $100,000 principal into 22,222 shares of the Company’s 
common stock at a conversion price of $4.50.  As a result of the conversion, the Company reclassified $88,001 of the derivative liability related 
to  the  embedded  conversion  feature  to  additional  paid  in  capital  and  accelerated  the  recognition  of  $25,989  of  unamortized  debt  discount  as 
interest expense.  

On January 15, 2010, the holders of the October 2007 Debentures converted $100,000 principal into 22,222 shares of the Company’s 

   
 
 
   
   
   
   
   
   
   
 
 
 
 
   
   
   
   
   
common  stock  at  a  conversion  price  of  $4.50.  As  a  result  of  the  conversion,  the  Company  reclassified  $114,693  of  the  derivative 
liability related to the embedded conversion feature to additional paid in capital and accelerated the recognition of $25,451 of unamortized debt 
discount as interest expense.  

On  February  19,  2010,  the  Company  entered  into  an  Amended  and  Restated  Amendment  Agreements  with  the  holders  of  the 
Company’s Debentures (as hereinafter defined), which was amended on February 23, 2010 (collectively, the “2010 Amendment”), pursuant to 
which  the  Company  amended  and  restated  the  amendment  agreements  entered  into  on  January  12,  2010  and  February  1,  2010  with  the 
holders.  Pursuant to the 2010 Amendment, the debenture holders confirmed their prior agreement to defer until March 1, 2010 the Company’s 
obligation to make the January 1, 2010 and February 1, 2010 debenture amortization payments (each in the aggregate amount of $200,000) and 
their consent to the Company’s recent 10-to-1 reverse stock split. The following is a summary of the material terms of the 2010 Amendment:  

•  

each holder converted $1,357,215 in principal amount of the outstanding principal balance of such holder’s debenture in exchange 
for a number of shares of common stock determined by dividing such principal amount by the unit offering price in the Company’s 
equity financing  on February 25, 2010 (see  Note 10). Based on the public  offering  price  of $3.00 per unit, each holder received a 
total of 452,405 shares of common stock upon conversion.  As a result of the conversion of an aggregate of $2,714,430 outstanding 
principal,  the  Company  reclassified  a  portion  of  the  derivative  liability  related  to  the  conversion  feature  of  the  Debentures  of 
$1,450,605 to additional paid in capital and accelerated the recognition of $554,720 of debt discount as interest expense;  

•   with respect to the remaining outstanding balance of the debentures after the foregoing conversions, the Company is not obligated to 
make any principal or interest payments until March 1, 2011, at which time the Company will be obligated to start making monthly 
principal and interest payments of $200,000 for a period of seventeen (17) months with a final balloon payment due on August 1, 
2012. In addition, the future interest of $163,573 (in the aggregate) that would accrue on the outstanding principal balance from July 
1, 2010 (the date to which accrued interest was previously added to principal) to March 1, 2011 was added to the current principal 
balance of the debentures with a corresponding increase to the debt discount to be amortized over the remaining life of the debt;  

F-20 

   
   
   
   
  
  
•  

the conversion price of the remaining outstanding balance of each debenture was reset to $3.00 based on the public offering price;  

•  

•  

the exercise price of the warrants currently held by the debenture holders was reset to $3.30 per share which is equal to the exercise 
price of the warrants included as part of the units sold in the public offering (110% of the unit offering price) and the exercise period 
was extended to January 1, 2015;  

the termination of certain anti-dilution provisions contained in the debentures and warrants held by the debenture holders and their 
right to maintain a fully-diluted ownership of our common stock equal to 34.5%, which, along with the reset of the conversion price 
to $3.00 per share and warrant exercise price to $3.30 per share, resulted in the reclassification of $9,009,329 of derivative liability 
related  to  the  embedded  conversion  features  and  warrants  to  additional  paid  in  capital  since  the  modification  to  the  terms  of  the 
warrants no longer required derivative accounting;  

•  

the termination of certain financial covenants as described above; and  

•  

each executed a lock-up agreement covering a period of 180 days following the effective date of the registration statement; provided, 
however,  that  in  the  event  that  on  any  trading  day  during  the  lock-up  period  the  trading  price  of  the  Company’s  common  stock 
exceeds 200% of the offering price of the units, then each holder may sell at sales prices equal to or greater than 200% of such unit 
offering price a number of shares of common stock on that trading day (such day referred to as an “Open Trading Day”) equal to up 
to 10% of the aggregate trading volume of the Company’s common stock on the primary market on which it is trading on such Open 
Trading Day, and (ii) in the event on any trading day during the lock-up period the trading price of the Company’s common stock 
exceeds 300% of the unit offering price (also referred to as an Open Trading Day), each holder may sell at sales prices equal to or 
greater  than  300% of  such  unit  offering price  an  unlimited  number of  shares  of common  stock  on  such  Open  Trading Day.  Sales 
under the foregoing clause (ii) on any particular Open Trading Day shall not be aggregated with sales under the foregoing clause (i) 
on the same Open Trading Day for purposes of calculating the 10% limitation under clause (i).  

During  the  years  ended  March  31,  2010  and  2009,  the  Company  recognized  an  aggregate  of  $5,291,574  and  $2,223,116  in  interest 
expense,  respectively,  due  to  amortization  of  debt  discount  related  to  the  warrants  and  embedded  conversion  features  associated  with  the 
Company’s outstanding Debentures.  

Private Placement Debentures  

In March 2009, the Company entered into an Agency Agreement with a broker to raise capital in a private placement offering of one-
year  convertible  debentures  pursuant  to  Regulation  D  of  the  Securities  Act  of  1933  and  the  Rules  promulgated  thereunder  (the  “Private 
Placement  Debentures”).   As  of  March  31,  2010,  the  Company  had  received total  gross  proceeds  of  $1,381,500  under  this  private  placement 
offering of convertible debentures which includes gross proceeds of $1,321,500 raised during the year ended March 31, 2010.  

The Company had  the option to  make  principal redemptions on the maturity dates of the debentures in shares of common stock  at a 
conversion price of $5.10 per share. At any  time, holders were able  to convert the debentures into  shares of common stock at  the conversion 
price of $5.10. The conversion price was subject to adjustment in the event the Company issued its next equity financing of at least $2,500,000 at 
a price below $5.10 per share.  The Private Placement Debentures were converted to shares of common stock in February 2010 (see below).  

Per  the  terms  of  the  convertible  debenture  agreements,  the  notes  had  a  term  of  one  year  from  issuance  and  were  redeemable  by  the 
Company with two days notice.  The notes bore interest at 8% per annum and were convertible into shares of the Company’s common stock at a 
conversion  rate  of  $5.10  per  share.  In  connection  with  the  Private  Placement  Debentures,  the  Company  issued  to  investors  an  aggregate  of 
54,177  five-year  warrants  to  purchase  shares  of  the  Company’s  common  stock  at  $5.10  per  share  (the  “Private  Placement  Warrants”),  which 
included 51,824 warrants issued to investors during the year ended March 31, 2010, and were accounted for as derivative liabilities (see Note 9). 
The Company had determined the aggregate fair value of the issued warrants as of the dates of each grant, based on the Black-Scholes pricing 
model, to be approximately $291,570 for the year ended March 31, 2010. The exercise price of the warrants is subject to adjustment in the event 
the Company issues its next equity financing of at least $2,500,000 at a price below $5.10 per share.  At March 31, 2010, the aggregate fair value 
of the Private Placement Warrants was $98,787 and was accounted for as a derivative liability (see Note 9).  

In connection with the issuance of the Private Placement Debentures, the Company recognized a debt discount and derivative liability at 
the dates of issuance in the aggregate amount of $1,125,772 related to the fair value of the warrants and embedded conversion features, which 
included  $1,080,201  of  debt  discount  recorded  during  the  year  ended  March  31,  2010  comprised  of  $788,631  related  to  the  fair  value  of  the 
embedded conversion features and $291,570 related to the fair value of the warrants.  Prior to conversion, the debt discount was amortized to 
interest  expense  over  the  life  of  the  debentures  and  the  derivative  liability  was  revalued  each  reporting  period  with  changes  in  fair  value 
recognized in earnings.  

   
   
   
   
   
 
 
 
   
   
   
   
  
  
  
  
  
On February 25, 2010, immediately prior to the Company’s public offering, the holders of the Private Placement Debentures converted 
the principal balance of $1,381,500 and accrued interest of $78,701 into 519,187 shares of the Company’s common stock at a conversion price 
of  $2.81  in  prepayment  of  all  amounts  due.  As  a  result  of  the  conversion,  the  Company  reclassified  the  derivative  liability  related  to  the 
conversion feature of the Private Placement Debentures of $273,465 to additional paid in capital and  recognized the remaining debt discount of 
approximately  $331,002  as  interest  expense.  In  addition,  pursuant  to  the  anti-dilution  provisions  contained  in  the  Private  Placement  Warrant 
agreements, the exercise price of the Private Placement Warrants was reset from $5.10 per share to $2.81 per share and the Company recorded a 
loss of $2,756 in other expense, net and a corresponding increase in derivative liabilities (see Note 9).  

During the year ended March 31, 2010, the Company issued 16,253 warrants with an exercise price of $5.10 per share for commissions 
due in connection with the Company’s Private Placement Debentures.  The Company determined the aggregate fair value of the issued warrants, 
based on the Black-Scholes pricing model, to be $63,396, or $3.90 per share as of the effective date of grant, and was recorded in equity with a 
corresponding charge to deferred financing fees to be amortized to interest expense over the remaining life of the debt.  The remaining balance 
of $21,132 was charged to interest expense upon conversion of the Private Placement Debentures in February 2010.  

During the year ended March 31, 2010, the Company recognized an aggregate of $1,125,772 in interest expense due to amortization of 
debt  discount  related  to  the  warrants  and  embedded  conversion  features  associated  with  the  Company’s  outstanding  Private  Placement 
Debentures.     There  were  no  corresponding  amounts  recognized  during  the  year  ended  March  31,  2009  related  to  the  Private  Placement 
Debentures.  

F-21 

   
   
   
Convertible debentures mature in fiscal years ending after March 31, 2010 as follows:  

Years Ending March 31,  

2011  
2012  
2013  
2014  
2015  
Thereafter  

Note 9.  Derivative Liabilities  

   $  

Amount  

200,000   
2,400,000   
630,568   
—  
—  
—  

   $  

3,230,568   

As  described in Note 1, the  Company adopted  a new accounting  principle which  required  certain  instruments to be  accounted for as 

derivative liabilities.  The Company’s derivative liabilities balance as of March 31, 2010 was $334,363.  

In accordance with current accounting guidance (see Note 1), the Company’s outstanding warrants to purchase shares of common stock 
and embedded conversion features in convertible notes payable previously treated as equity were no longer afforded equity treatment because 
these instruments have reset or ratchet provisions that are triggered in the event the Company raises additional capital at a lower price, among 
other  adjustments.  As  such,  effective  April  1,  2009  the  Company  reclassified  the  fair  value  of  these  common  stock  purchase  warrants  and 
embedded conversion features, from equity  to liability status as if these  warrants and  conversion features were treated  as derivative liabilities 
since  their  dates  of  issuance  or  modification.  Any  change  in  fair  value  subsequent  to  April  1,  2009  is  recorded  as  non-operating,  non-cash 
income  or  expense  at  each  reporting  date.  If  the  fair  value  of  the  derivatives  was  higher  at  the  subsequent  balance  sheet  date,  the  Company 
recorded  a  non-operating,  non-cash  charge.  If  the  fair  value  of  the  derivatives  was  lower  at  the  subsequent  balance  sheet  date,  the  Company 
recorded  non-operating,  non-cash  income.  The  cumulative  effect  at  April  1,  2009  to  record,  at  fair  value,  a  liability  for  the  warrants  and 
embedded conversion  features,  and related  adjustments to discounts  on  convertible  notes  of  $2,595,095,  resulted  in  an  aggregate  reduction  to 
equity  of  $13,875,623  consisting  of  a  reduction  to  additional  paid-in  capital  of  $4,217,730  and  an  increase  in  the  accumulated  deficit  of 
$9,657,893 to reflect the adoption of new accounting guidance.  

Fiscal Year 2010 Activity  

In July 2009, as a result of the July Agreement, the exercise price of the Debenture Warrants was decreased from $6.00 per share to 
$5.10 per share, which resulted in an increase in the liability for derivative instruments of $1,608,540 and a corresponding loss was recorded in 
other expense, net due to the change in fair value of derivative liabilities (see Note 8).  

In  September  2009,  as  a  result  of  the  September  Amendment,  the  conversion  price  of  the  Debentures  and  the  exercise  price  of  the 
Debenture  Warrants  was  decreased  from  $5.10  per  share  to  $4.50  per  share,  pursuant  to  the  terms  of  the  Debentures,  which  resulted  in  an 
aggregate increase in the liability for derivative instruments of $1,679,990 and a corresponding loss was recorded in other expense, net due to the 
change in fair value of derivative liabilities. In addition, the conversion price of the Debentures was decreased from $5.10 per share to $4.50 per 
share,  which  resulted  in  an  increase  in  the  number  shares  of  common  stock  which  the  Debentures  may  be  converted  into,  an  increase  in  the 
liability for derivative instruments of $802,200 and a corresponding loss was recorded in other expense, net and included in the change in fair 
value of derivative liabilities (see Note 8).  

In February 2010, as a result of the conversion of all outstanding amounts due under the Private Placement Debentures, the Company 
reclassified  the derivative  liability  for the  embedded conversion feature  of  $273,465  to  additional  paid  in capital.  In addition,  pursuant to the 
anti-dilution provisions contained in the Private Placement Warrant agreements, the exercise price of the Private Placement Warrants was reset 
from  $5.10  per  share  to  $2.81  per  share.  The  Company  recorded  an  increase  in  the  liability  for  derivative  instrument  of  $2,756  and  a 
corresponding loss was recorded in other expense, net and included in the change in fair value of derivative liabilities.  The Company determined 
the  aggregate  fair  value  of  the  warrants,  based  on  the  Black-Scholes  pricing  model,  to  be  $98,786  as  of  March  31,  2010.  See  Note  8  for  a 
discussion of the fair value of the warrants and embedded conversion features as of the dates of issuance.  

In February 2010, as a result of the 2010 Amendment, the exercise price of the Debenture Warrants was decreased from $4.50 per share 
to $3.30 per share, pursuant to the terms of the Debentures, which resulted in an increase in the liability for derivative instruments of $231,093 
and a corresponding loss was recorded in other expense, net due to the change in fair value of derivative liabilities.  In addition, the conversion 
price of the Debentures was decreased from $4.50 per share to $3.00 per share which resulted in an increase in the number of shares of common 

   
   
 
   
   
   
 
   
   
   
  
  
  
     
  
   
     
     
     
     
     
  
     
  
  
  
stock  which  the  Debentures  may  be  converted  into,  an  increase  in  the  liability  for  derivative  instrument  of  $1,376,043  and  a 

corresponding loss was recorded in other expense, net and included in the change in fair value of derivative liabilities (see Note 8).  

In February 2010, as a result of the 2010 Amendment and partial conversion of the Debentures, the Company reclassified a portion of 
the  derivative  liability  related  to  the  conversion  feature  of  the  Debentures  of  $1,653,299  to  additional  paid  in  capital.  In  addition,  due  to  the 
modification  of  the  terms  of  the  Debentures,  the  remaining  derivative  liabilities  for  the  embedded  conversion  features  and  warrants  of 
$9,009,329 was reclassified to additional paid in capital as they no longer require derivative treatment (see Note 8).  

During the year ended March 31, 2010, the Company issued to various placement agents in lieu of cash fees an aggregate of 20,000 
warrants to purchase shares of the Company’s common stock with a fair value of $87,448. The exercise prices of these warrants are equal to 
$3.30, as reset from $5.10 on February 25, 2010 pursuant to the anti-dilution provisions contained in the warrant agreements and an additional 
10,909  warrant shares were  issued  for an  aggregate  total  of  30,909 warrants. The Company  determined the aggregate fair value of the  issued 
warrants, based on the Black-Scholes pricing model, to be $55,961 as of March 31, 2010. Since the exercise price of the warrants is subject to 
adjustment in the event the Company issues the next equity financing, the warrants are accounted for as a derivative liability.  

During the year ended March 31, 2010, the Company modified the terms of an aggregate of 54,676 warrants to purchase shares of the 
Company’s common stock which were previously issued to various placement agents in lieu of cash fees. On April 5, 2009, in connection with 
the  termination  of  a  consulting  agreement,  the  Company  modified  the  terms  of  54,676  warrants  issued  in  October  2007  and  May  2008.  The 
exercise price of the warrants was reduced from $8.40 per share to $6.00 per share and the expiration date was extended to 5 years from the date 
of modification. As a result of the modification, the Company recognized expense of $10,763 in other expense, net based on the change in the 
Black-Scholes fair value before and after modification.  On February 25, 2010, the exercise price of the warrants was reduced from $6.00 per 
share to  $3.30 per share  pursuant  to the  anti-dilution  provisions contained  in the  warrant agreements  and an  additional 44,735  warrant shares 
were  issued,  for  an  aggregate  total  of  99,411  warrant  shares.  The  Company  recorded  an  increase  in  the  liability  for  derivative  instrument  of 
$5,225  and  a  corresponding  loss  was  recorded  in  other  expense,  net  and  included  in  the  change  in  fair  value  of  derivative  liabilities.  The 
Company determined the aggregate fair value of the issued warrants, based on the Black-Scholes pricing model, to be $179,616 as of March 31, 
2010.  Since the exercise price of the warrants is subject to adjustment in the event the Company issues the next equity financing, the warrants 
are accounted for as a derivative liability.  

F-22 

   
   
   
   
During  the  year  ended  March  31,  2010,  the  Company  recognized  a  net  gain  of  $5,576,979  due  to  the  change  in  fair  value  of  its 
derivative instruments. See Note 8, for the components of changes in derivative liabilities. During the year ended March 31, 2009, there were no 
derivative  liabilities  and  therefore  no  recognized  changes  in  fair  value.  The  Company’s  common  stock  purchase  warrants  do  not  trade  in  an 
active securities market, and as such, the Company estimated the fair value of these warrants using the Black-Scholes option pricing model using 
the following assumptions:  

Expected dividends  
Expected term (in years)  
Risk-free interest rate  
Expected volatility  

   March 31,  

2010  
—  
3.50 – 5.00     
     1.42% – 2.69%   
     178% – 204%    

Historical  volatility  was  computed  using  daily  pricing  observations  for  recent  periods  that  correspond  to  the  remaining  term  of  the 
warrants, which had an original term of five years from the date of issuance. The expected life is based on the remaining term of the warrants. 
The risk-free interest rate is based on U.S. Treasury securities with a maturity corresponding to the remaining term of the warrants.  

The  Company  estimated  the  fair  value  of  the  embedded  conversion  features  related  to  its  convertible  debentures  using  the  Black-

Scholes option pricing model using the following assumptions:  

Expected dividends  
Expected term (in years)  
Risk-free interest rate  
Expected volatility  

   March 31,  

2010  
—  
0.09 – 2.43     
     0.06% – 1.65%   
     81% – 150%     

Historical volatility was computed using daily pricing observations for recent periods that correspond to the remaining life of the related 
debentures.  The  expected  life  is  based  on  the  remaining  term  of  the  related  debentures.  The  risk-free  interest  rate  is  based  on  U.S.  Treasury 
securities with a maturity corresponding to the remaining term of the related debentures.  

Note 10.  Stockholders’ Equity  

Common Stock  

The Company’s authorized capital consists of 250,000,000 shares of common stock, $0.001 par value per share.  On February 5, 2010, 
the Company filed a Certificate of Amendment to Amended and Restated Articles of Incorporation with the Secretary of State of the State of 
Nevada  to  effect  a  10-to-1  reverse  stock  split  of  the  Company’s  issued  and  outstanding  shares  of  common  stock.  As  of  March  31,  2010  and 
2009, 8,136,619 and 4,186,194 shares of common stock were issued and outstanding, respectively.  

Fiscal Year 2009 Activity  

In October 2007, the Company engaged the firm of Carpe DM, Inc. to perform the services as the Company’s investor relations and 
public  relations  representative  for  a  monthly  fee  of  $7,500  per  month.  Pursuant  to  the  terms  of  this  36  month  consulting  agreement,  the 
Company issued 15,000 shares of common stock at a price of $8.00 per share and a total value of $120,000, the resale of which is registered on a 
Form S-8 registration statement and 25,000 fully vested and non-forfeitable warrants at an exercise price of $15.00 per share for a period of two 
and one-half years, valued at $229,834 as calculated using the Black-Scholes option pricing model.  On November 13, 2007, the Company filed 
the  Form  S-8  as  required  by  this  agreement  with  the  Securities  and  Exchange  Commission.  The  Company  recorded  the  combined  value  of 
$349,834 for the issued shares and warrants as prepaid expense and was amortized over the life of the services agreement which was terminated 
during fiscal year 2010.  As of March 31, 2010 and 2009, the unamortized balance of the value of the shares and warrants issued to Carpe DM, 
Inc. was $0 and $174,928, respectively.  Amortization expense related to the value of the shares and warrants was $174,928 and $116,604 for the 
years ended March 31, 2010 and 2009, respectively and is included in selling, general and administrative expenses.  

In  April  2008,  the  Company  rescinded  and  cancelled  14,014  shares  of  registered  common  stock  for  principal  redemptions  of  the 
October  2007  Debentures  totaling  $117,720  and  submitted  the  cash  payments  in  the  same  amounts  to  those  holders.  Pursuant  to  a  one-time 
waiver of certain equity conditions, the remaining $70,588 of the March 31 principal redemption was adjusted to reflect a one-time conversion 
rate of $7.00 and, in April 2008 the Company issued the holder 1,681 additional registered shares in consideration. In addition, the March 31, 

   
   
   
   
   
   
   
 
   
   
 
   
  
  
  
    
  
    
  
  
  
    
  
    
2008 interest payments were adjusted to reflect a one-time conversion price of $7.00 and in April 2008 the Company issued the October 
2007  Debenture  holders  2,209  additional  common  stock  shares.  The  additional  interest  expense  for  the  October  2007  Debentures  of  $5,446 
related to the one-time conversion rate adjustments of the March 31, 2008 principal and interest payments from $8.40 to $7.00 was included in 
accrued interest for the October 2007 Debentures as of March 31, 2008.  

During fiscal 2009, the Company issued 24,472 shares of restricted common stock in lieu of fees paid to various consultants for services 
performed. These shares were issued at an average price of $6.90 (based on the underlying stock prices on the dates of issuances) for a total cost 
of $168,769 which has been included in selling, general and administrative expenses for the year ended March 31, 2009.  

F-23 

   
   
During  fiscal  2009,  the  Company  issued  8,269  shares  of  common stock resulting  from  exercises  of  stock  options  and  warrants  at  an 
average  price  of  $0.40  per  share  for  proceeds  of  $3,307  and  issued  15,002  shares  of  common  stock  from  the  cashless  exercises  of  a  total  of 
15,700 stock options.  

Under the terms of the January Amendment, in February 2009, the Company issued a total of 40,000 restricted common stock shares to 
the October 2007 and May 2008 Debenture Holders. The total fair value of the shares issues totaled $164,000 and has been included in the loss 
on extinguishment of debt for the year ended March 31, 2009.  

In  March  2009,  the  Company  issued  15,752  S-8  registered  shares  of  common  stock  in  lieu  of  fees  paid  for  services  performed  by 
consultants. On March 28, 2009, the Company filed the Form S-8 with the Securities and Exchange Commission. These shares were issued at a 
value of $5.10 per share for a total cost of $80,333 which has been included in selling, general and administrative expenses for the year ended 
March 31, 2009.  

Fiscal Year 2010 Activity  

On September 28, 2009, the Company issued 2,353 shares of common stock, in lieu of $12,000 in fees paid for services performed by 
Carpe DM, Inc., which were issued at a value of $5.10 per share (also see additional Carpe DM transactions in “ Fiscal Year 2009 Activity  ”
above).  

In  May  2009,  $713,000  of  the  October  2007  Debentures  was  converted  by  the  note  holders.  Using  the  conversion  rate  of  $5.10  per 

share per the terms of the Debenture, 139,804 shares of registered common stock were issued to the investors.  

In July 2009, the Company engaged an agent to solicit the holders of certain warrants to exercise their rights to purchase shares of the 
Company’s common stock.  Pursuant to the terms of the engagement, the Company agreed to pay the agent compensation of 5% of the gross 
proceeds totaling  $76,632,  which  is  included  equity  and  netted  against  the  gross  proceeds  in  the  accompanying  consolidated  balance  sheet  at 
March 31, 2010.  In addition, the Company issued to the agent a warrant to purchase a number of shares of the Company’s common stock equal 
to  5%  of  the  number  of  shares  issued  in  the  exercise  of  the warrants,  or  a  total  of  23,952  warrants  with  a  fair  value  of  $98,256  or  $4.10  per 
share.  The warrant has an exercise price of $5.10 and will permit the agent or its designees to purchase shares of common stock on or prior to 
October  1,  2014.  The  fair  value  of  warrants  has  been  recorded  as  an  offset  to  additional  paid  in  capital  on  the  accompanying  consolidated 
balance  sheet.  During  the  year  ended  March  31,  2010,  the  Company  issued  479,033  shares  of  its  common  stock  for  gross  cash  proceeds  of 
$1,437,100 from the exercise of warrants which resulted from the solicitation.  

During July 2009, the Company entered into the July Agreement with the holders of the Company’s Debentures (see Note 8). Pursuant 
to the terms of the July Agreement, the Holders (i) consented to the Company’s issuance of convertible notes and warrants in connection with 
the Bridge Financing of up to $1,500,000 which commenced in March 2009, and (ii) waived, as it relates to the Bridge Financing, a covenant 
contained in the Debentures not to incur any further indebtedness, except as otherwise permitted by the Debentures. This Bridge Financing is 
more  particularly  described  in  Note  8  above  under  the  caption  “Private  Placement  Debentures.”  In  addition,  in  connection  with  the  July 
Agreement,  the  Company  and  Holders  confirmed  that  (i)  the  exercise  price  of  the  warrants  issued  to  the  Holders  in  connection  with  their 
purchase of the Debentures had been reduced, pursuant to the terms of the warrants, to $5.10 as a result of the Bridge Financing, and (ii) as a 
result of the foregoing decrease in the exercise price, pursuant to the terms of the warrants, the number of shares underlying the warrants held by 
Holders of the Debentures had been proportionally increased by 404,350 pursuant to the terms of the warrant agreements (see Note 8).  

In August 2009, the Company issued warrants to purchase 600 shares of common stock in lieu of payment to Gary C. Cannon, who 
then  served  as  Corporate  Legal  Counsel  for  the  Company  and  as  a  member  of  the  Advisory  Board,  to  purchase  shares  of  the  Company’s 
common stock at an exercise price of $5.10 per share with a five year term. The exercise prices of these warrants are greater than or equal to the 
stock price of the Company’s shares as of the date of grant. The fair market value of the warrants based on the Black-Scholes pricing model of 
$2,799 was recorded as consulting and compensation expense and included in selling, general and administrative expenses during the year ended 
March  31,  2010.  In  July  2009,  Mr.  Cannon  was  given  a  30  day  notice  of  his  termination  as  general  legal  counsel  and  advisor  to  the 
Company. During November 2009, the Company issued 4,314 shares of common stock to Mr. Cannon in lieu of payment for services for a total 
expense of $22,000 which has been included in selling, general and administrative expenses.  

Effective September 1, 2009, in connection with the September Amendment with the holders of the Debentures, the exercise price of 
the  Debenture  Warrants  was  reduced  to  $4.50  per  share  which  resulted  in  a  proportionate  increase  in  the  number  of  shares  that  may  be 
purchased upon the exercise of such warrants of 359,423 shares (see Note 8).  

In September 2009, $100,000 of the October 2007 Debentures was converted by the note holder.  Using the conversion rate of $4.50 per 

share per the terms of the Debentures, 22,222 share of registered common stock were issued to the investor.  

   
   
   
 
   
   
   
   
   
   
   
   
On October 30, 2009, the Company issued 5,881 shares of common stock, in lieu of fees paid for services performed by the Board of 

Directors.  These shares were issued at a value of $4.30 per share, for a total value of $25,288.  

During October and November 2009, the holders of the October 2007 Debentures converted $370,000 principal into 82,222 shares of 

the Company’s common stock at a conversion price of $4.50 per share per the terms of the Debentures (See Note 8).  

During January, 2010, the holders of the October 2007 Debentures converted $200,000 principal into 44,444 shares of the Company’s 

common stock at a conversion price of $4.50 per share per the terms of the Debentures (see Note 8).  

On February 19, 2010, we entered into the 2010 Amendment with the holders of  our Debentures (see Note 8).  Pursuant to the 2010 
Amendment,  the  holders  each  converted  $1,357,215  in  principal  amount  of  the  outstanding  principal  balance  of  such  holder’s  debenture  in 
exchange for a number of shares of common stock determined by dividing such principal amount by the unit offering price.  Based on the public 
offering price of $3.00 per unit, each holder received a total of 452,405 shares of common stock upon conversion.  The conversion price of the 
remaining outstanding balance of each debenture was reset to $3.00 based on the Company’s public offering price.  As a result of the conversion 
of  an  aggregate  of  $2,714,430  outstanding  principal,  the  Company  reclassified  a  portion  of  the  derivative  liability  related  to  the  conversion 
feature  of  the  Debentures  of  $1,450,605  to  additional  paid  in  capital.  In  addition,  pursuant  to  the  2010  Amendment,  certain  anti-dilution 
provisions  contained  in  the  debentures  and  warrants  held  by  the  debenture  holders  were  terminated  along  with  the  right  to  maintain  a  fully-
diluted ownership of our common stock equal to 34.5%, which resulted in the reclassification of $9,009,329 of derivative liability related to the 
embedded conversion features and warrants to additional paid in capital.  Pursuant to the terms of the 2010 Amendment, the exercise price of the 
warrants currently held by the debenture holders was reset to equal the exercise price of the warrants included as part of the units sold in the 
Company’s public offering (110% of the unit offering price or $3.30 per share) and the exercise period was extended to January 1, 2015.  

On  February  25,  2010  the  Company  completed  a  public  offering  of  units  consisting  of  1,666,667  shares  of  the  Company’s  common 
stock and 1,666,667 warrants to purchase one share of the Company’s common stock for gross proceeds of $5,000,001 and net cash proceeds of 
approximately  $3,742,097.  Each  unit  consisting  of  one  share,  together  with  one  warrant  to  purchase  one  share,  was  priced  at  $3.00.  The 
warrants  issued  as  part  of  the  offering  have  an  exercise  price  of  $3.30  and  a  term  of  5  years.  In  addition,  the  Company  issued  a  warrant  to 
purchase 83,333 shares of the Company’s common stock to the underwriter’s representative at an exercise price of $3.75 with a 5 year term and 
have a fair value of $199,043 based on the Black-Scholes pricing model.  Pursuant to the offering, the Company issued to an investment banker 
warrants to purchase 17,500 shares of the Company’s common stock with a fair value of $41,939, which represented 7% of the warrants issued 
to the holders of the Company’s Debentures participating in the public offering, at an exercise price of $3.30 per share and a 5 year term.  

F-24 

   
   
   
   
   
During the year ended March 31, 2010, the Company issued to the purchasers of the Private Placement Debentures warrants to purchase 
an  aggregate  of  51,824  shares  of  common  stock  at  an  initial  exercise  price  of  $5.10.  In  February  2010,  immediately  prior  to  the  Company’s 
public offering, the holders of the Private Placement Debentures converted the aggregate principal balance of $1,381,500 and accrued interest of 
$78,701 into 519,186 shares of the Company’s common stock at a conversion price of $2.81 in prepayment of all amounts due.  As a result of 
the conversion of all outstanding amounts, the Company reclassified the derivative liability for the embedded conversion feature of $273,465 to 
additional  paid  in  capital.  In  addition,  pursuant  to  the  anti-dilution  provisions  contained  in  the  Private  Placement  Warrant  agreements,  the 
exercise price of the Private Placement Warrants was reset from $5.10 per share to $2.81 per share (see Notes 8 and 9).  

On  March  23,  2010,  the  Company  issued  warrants  to  purchase  15,000  shares  of  the  Company’s  common  stock  with  a  fair  value  of 
$27,426  to  an  agent  for  continued  shareholder  support  at  an  exercise  price  of  $1.91  per  share.  The  warrants  were  recorded  in  equity  with  a 
corresponding charge to general and administrative expense.  

During the year ended March 31, 2010, the Company issued 20,000 warrants to purchase shares of the Company’s common stock to 
various  placement  agents.  The  warrants  were  issued  in  April  2009  with  a  fair  value  of  $87,448  and  an  exercise  price  of  $5.10  and  were 
classified as derivative liabilities.  The exercise price of these warrants was reset to $3.30 per share from $5.10 per share on February 25, 2010 
pursuant  to  the  anti-dilution  provisions  contained  in  the  warrant  agreements,  and  an  additional  10,909  warrant  shares  were  issued  for  an 
aggregate total of 30,909 warrants (see Note 9).  

During  the  year  ended  March  31,  2010,  the  Company  modified  the  terms  of  54,676  warrants  to  purchase  shares  of  the  Company’s 
common  stock  which  were  previously  issued  to  various  placement  agents  and  currently  classified  as  derivative  liabilities.  In  April  2009,  the 
exercise price of the warrants was reduced from $8.40 per share to $6.00 per share and the expiration date was extended to 5 years from the date 
of modification.  On February 25, 2010, the exercise price of the warrants was reduced from $6.00 per share to $3.30 per share pursuant to the 
anti-dilution  provisions  contained  in  the  warrant  agreements  and  an  additional  44,735  warrant  shares  were  issued,  for  an  aggregate  total  of 
99,411 warrant shares.  See Note 9 for a discussion of the accounting impact.  

During  the  year  ended  March  31,  2010,  the  Company  issued  4,719  shares  of  common  stock  upon  the  cashless  exercise  of  a  total  of 
11,640  warrants  at  an  average  exercise  price  of  $2.80  per  share  and  11,034  shares  of  common  stock  upon  the  cashless  exercise  of  a  total  of 
11,900 options at an average exercise price of $0.40 per share.  

During  the  year  ended  March  31,  2010,  the  Company  issued  20,942  shares  of  common  stock  the  resale  of  which  was  registered 
pursuant to Form S-8 in lieu of fees paid for services performed by consultants.  On April 13, 2009 and June 11, 2009, the Company filed the 
related Forms S-8 with the SEC.  These shares were issued at a value of $5.10 per share with a total value of $106,806 which has been included 
in selling, general and administrative expenses for the year ended March 31, 2010.  

During the year ended March 31, 2010, the Company converted interest payments due on the Debentures totaling $171,253 into 42,814 

shares of common stock using the conversion rate of $4.00 per share.  

During  the  year  ended  March  31,  2010,  a  total  of  21,000  warrants  and  190,553  stock  options  with  a  weighted  average  fair  value  of 

$3.53 per share were granted to employees and directors (see Note 11).  

During  the  year  ended  March  31,  2010,  the  Company  issued  16,253  warrants  with  a  fair  value  of  $63,396  or  $3.90  per  share  for 

commissions due in connection with the Company’s Private Placement Debentures (see Note 8).  

The  following  summary  information  reflects  warrants  outstanding  as  of  March  31,  2010  (other  than  those  issued  to  the  Company’s 

employees, officers, directors and related consultants presented in the Stock Compensation Plan Section below) and other related details:  

Year of Grant  
(as of March 31)  

2003  
2008  
2009  
2010  

Exercise Price  

$5.00  
$1.50 - $35.00  
$2.81 - $8.50  
$1.91 - $5.10  

Warrants Outstanding  
Number Outstanding,  
Vested and Exercisable  

Remaining Contractual  
Life (Years)  

20,000   
1,778,573   
659,881   
2,769,223   
5,227,677   

0.68  
3.71  
3.25  
5.14  

   
   
   
   
   
   
   
   
   
   
 
 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
F-25 

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 11.  Stock Compensation Plan  

The  Company  accounts  for  share-based  payments  to  employees  and  directors  in  accordance  with  share-based  payment  accounting 
literature which requires all share-based payments to employees and directors, including grants of employee stock options and warrants, to be 
recognized in the consolidated financial statements based upon their fair values. The Company uses the Black-Scholes option pricing model to 
estimate the grant-date fair value of share-based awards. Fair value is determined at the date of grant. The consolidated financial statement effect 
of forfeitures is estimated at the time of grant and revised, if necessary, if the actual effect differs from those estimates. The estimated average 
forfeiture rate for the years ended March 31, 2010 and 2009 was zero, as the Company has not had a significant history of forfeitures and does 
not expect forfeitures in the future.  

Cash flows resulting from the tax benefits resulting from tax deductions in excess of the compensation cost recognized for those options 
or warrants to be classified as financing cash flows.  Due to the Company’s loss position, there were no such tax benefits during the years ended 
March 31, 2010 and 2009.  

Plan Descriptions  

The Company maintains two stock option plans, the 2002 Stock Incentive Plan (the “2002 Plan”) and the 2009 Stock Incentive Plan 
(the “2009 Plan”). The 2002 Plan provides for grants of incentive stock options and nonqualified options to employees, directors and consultants 
of the Company to purchase the Company’s shares at the fair value, as determined by management and the board of directors, of such shares on 
the grant date. The options are subject to various vesting conditions and generally vest over a three-year period beginning on the grant date and 
have seven to ten-year term. The 2002 Plan also provides for the granting of restricted shares of common stock subject to vesting requirements. 
The Company is authorized to issue up to 500,000 shares under this plan and has 393,736 shares available for future issuances as of March 31, 
2010.  

On  October  9,  2009,  the  Company’s  stockholders  approved  and  adopted  the  2009  Plan,  which  had  previously  been  approved  by  the 
Company’s Board of Directors on August 31, 2009. The 2009 Plan provides for the grant of incentive stock options, nonqualified stock options, 
restricted  stock  rights,  restricted  stock,  performance  share  units,  performance  shares,  performance  cash  awards,  stock  appreciation  rights,  and 
stock  grant  awards  (collectively,  “Awards”)  to  employees,  officers,  non-employee  directors,  consultants  and  independent  contractors  of  the 
Company. The 2009 Plan also permits the grant of awards that qualify for the “performance-based compensation” exception to the $1,000,000 
limitation  on  the  deduction  of  compensation  imposed  by  Section  162(m)  of  the  Internal  Revenue  Code.  A  total  of  1,200,000  shares  of  the 
Company’s common stock are authorized for the granting of Awards under the 2009 Plan. The number of shares available for future awards, as 
well as the terms of outstanding awards, is subject to adjustment as provided in the 2009 Plan for stock splits, stock dividends, recapitalizations 
and other similar events. Awards may be granted under the 2009 Plan until October 9, 2019 or until all shares available for awards under the 
2009 Plan have been purchased or acquired. The Company is authorized to issue up to 1,200,000 shares under this plan and has 1,023,047 shares 
available for future issuances as of March 31, 2010.  

In  addition  to  the  stock  options  issued  pursuant  to  the  Company’s  two  stock  option  plans,  the  Company  has  granted  warrants  to 
employees,  officers,  non-employee  directors,  consultants  and  independent  contractors.  The  warrants  are  generally  not  subject  to  vesting 
requirements and have ten-year terms.  At March 31, 2010 there were 16,667 warrants outstanding subject to vesting conditions.  

As  of  March 31,  2010,  a  total  of  65,395  and  176,953  shares  of  common  stock  were  reserved  for  issuance  under  the  2002  and  2009 
Stock Plans, respectively, and a total of 312,855 shares of common stock were reserved for issuance upon exercise of outstanding warrants.  A 
summary of the Company’s employee and director stock option and warrant activity and related information during the 2010 fiscal year follows:  

Outstanding at April 1, 2009  
Granted  
Exercised  
Canceled  

Number of  
 Shares  

Weighted- 
Average  
 Exercise Price    
6.88   
3.54   
1.12   
5.37   

523,388      $ 
211,553      $ 
(15,753 )    $ 
(163,985 )    $ 

Remaining  
 Contractual Life   

Aggregate  
 Intrinsic Value    

6.82     

    $ 

79,964   

Outstanding and expected to vest at March 31, 2010  

555,203      $ 

6.22   

7.55   $ 

29,907   

 
   
    
   
   
    
    
   
   
   
   
  
  
    
    
    
      
    
    
        
  
  
    
        
    
        
  
    
Exercisable at March 31, 2010  

378,533      $ 

7.46   

7.00   $ 

29,907   

F-26 

   
  
    
        
    
        
  
    
CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

The following summary information reflects stock options and warrants outstanding, vesting and related details as of March 31, 2010:  

Year of Grant 
(as of March 31)  

2002  
2003  
2004  
2005  
2006  
2007  
2008  
2009  
2010  

   Exercise Price  
   $ 

10.00        
—       
6.00        
0.40 – 6.00        
—       
2.80 – 10.00        
7.50 – 10.80        
5.10 – 10.50        
2.20 – 8.30        

   $ 

Stock Options and Warrants Outstanding  
Remaining  
Contractual  
Life (Years)  

Vested and  
Exercisable  

Number  
Outstanding  

5,000        
—       
20,000        
26,795        
—       
111,335        
88,780        
91,740        
211,553        
555,203         

3.59         
—        
4.26         
3.34         
—        
6.45         
7.77         
7.13         
8.46         

5,000   
—  
20,000   
26,795   
—  
111,335   
88,780   
75,073   
51,550   
378,533   

The Company uses the Black-Scholes option-pricing model to recognize the value of stock-based compensation expense for all share-
based  payment  awards.  Determining  the  appropriate  fair-value  model  and  calculating  the  fair  value  of  stock-based  awards  at  the  grant  date 
requires  considerable  judgment,  including  estimating  stock  price  volatility,  expected  option  life  and  forfeiture  rates.  The  Company  develops 
estimates  based  on  historical  data  and  market  information,  which  can  change  significantly  over  time.  The  Black-Scholes  model  requires  the 
Company to make several key judgments including:  

•   The expected option term reflects the application of the simplified method set out in SAB No. 107 Share-Based Payment (SAB 107), 
which was issued in March 2005. In December 2007, the SEC released Staff Accounting Bulletin No. 110 (SAB 110), which extends 
the use of the “simplified” method, under certain circumstances, in developing an estimate of expected term of “plain vanilla” share 
options. Accordingly, the Company has utilized the average of the contractual term of the options and the weighted average vesting 
period for all options and warrants to calculate the expected option term.  

•   Estimated volatility also reflects the historical volatility pattern of the Company’s share price.  

•   The dividend yield is based on the Company’s historical pattern of dividends as well as expected dividend patterns.  

•   The risk-free rate is based on the implied yield of U.S. Treasury notes as of the grant date with a remaining term approximately equal 

to the expected term.  

•   Estimated  forfeiture  rate  of  0%  per  year  is  based  on  the  Company’s  historical  forfeiture  activity  of  unvested  stock  options.  The 

Company used the following assumptions for stock options and warrants granted during the years ended March 31, 2010 and 2009:  

Risk-free interest rate  
Expected volatility  
Expected life (in years)  
Expected dividend yield  

Years Ended March 31,  

2010  
1.38% – 3.04%  
179% – 197%  
3.50 – 6.02  
N/A  

2009  
1.52% – 3.15%  
201% – 266%  
5.00  
N/A  

F-27 

   
   
 
   
    
   
   
   
   
   
    
   
  
     
     
  
     
     
     
     
  
     
     
     
  
     
     
     
     
     
     
     
   
     
         
          
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
   
  
  
For the years ended March 31, 2010 and 2009, the following represent the Company’s weighted average fair value displayed by grant 

year:  

Grant Year  

March 31, 2010  
March 31, 2009  

Weighted 
Average  

     Fair Value of     
     Options and     
     Warrants  

Granted  

211,553     $ 
91,470     $ 

3.53   
5.08   

There were 21,000 warrants and 190,553 stock options for an aggregate of 211,553 shares granted to employees and directors during 
the year ended March 31, 2010 and 91,740 warrants and no stock options for an aggregate of 91,470 shares granted to employees and directors 
during the year ended March 31, 2009.  In connection with the warrants and options granted and the vesting of prior warrants issued, during the 
years ended March 31, 2010 and 2009, the Company recorded total charges of $559,561 and $289,497, respectively, which have been included 
in  selling,  general  and  administrative  expenses  in  the  accompanying  consolidated  statements  of  operations.   The  Company  issues  new  shares 
from its authorized shares upon exercise of warrants or options.  

As of March 31, 2010 and 2009, there was $471,401 and $287,722, respectively, of total unrecognized compensation cost, related to 

non-vested stock options and warrants, which is expected to be recognized over a remaining weighted average vesting period of 1.69 years.  

The aggregate intrinsic value of stock options and warrants exercised during the years ended March 31, 2010 and 2009 was $79,964 and 

$203,012, respectively.  

Note 12.  Commitments and Contingencies  

Lease Commitments  

On July 2, 2007, the Company entered into a lease agreement with Viking Investors - Barents Sea, LLC (Lessor) for a building with 
approximately  11,881  square  feet  of manufacturing  and office space  located  at  20382 Barents Sea  Circle, Lake  Forest, CA,  92630. The lease 
agreement is for a period of two years with renewal options for three, one-year periods, beginning September 1, 2007. The lease required base 
lease payments of approximately $10,000 per month plus operating expenses. In connection with the lease agreement, the Company issued to the 
lessor a warrant to purchase 1,000 shares of common stock at an exercise price of $15.50 per share for a period of two years, valued at $15,486 
as calculated using the Black Scholes option pricing model. The assumptions used under the Black-Scholes pricing model included: a risk free 
rate of 4.75%; volatility of 293%; an expected exercise term of 5 years; and no annual dividend rate. The Company capitalized and amortized the 
value of the warrant over the life of the lease and recorded the unamortized value of the warrant in other long-term assets.  For the years ended 
March 31, 2010 and 2009, the Company amortized $2,970 and $7,104, respectively.  As of March 31, 2010 the fair value of the warrant has been 
fully amortized.  On August 24, 2009, the Company entered into the second amendment to the lease for its manufacturing and office space. The 
amendment extended the lease for twelve months from the end of the existing lease term with a right to cancel the lease with a minimum of 120 
day  written  notice  at  anytime  as  of  November  30,  2009.   In  June  2010,  Company  entered  into  the  third  amendment  to  the  lease  for  its 
manufacturing and office space. The amendment extended the lease for sixty months commencing July 1, 2010 with a right to cancel the lease 
with a minimum of 120 day written notice at anytime as of December 31, 2012.  

In the event the Company does exercise its option to cancel the lease, the Company shall reimburse the Lessor for the unearned leasing 

commissions. Rent expense on the facilities and equipment during 2010 and 2009 was $144,728 and $182,765, respectively.  

Future annual minimum payments under operating leases are as follows:  

Years Ending March 31:  
2011  
2012  
2013  
2014  
2015  
Thereafter  

   $ 

89,812    
86,253    
90,177    
96,594    
104,793   
26,733    

   
   
   
   
   
 
 
 
   
   
   
  
    
    
  
  
    
  
    
  
  
  
      
        
  
    
    
     
  
     
     
     
    
     
  
         
  
   $ 

494,362    

The above schedule of future annual minimum payments has been adjusted to reflect the lease amendment entered into with the Lessor 
subsequent to year end (see Note 15).   

Litigation  

The Company may become a party to product litigation in the normal course of business. The Company accrues for open claims based 
on its historical experience and available insurance coverage. In the opinion of management, there are no legal matters involving the Company 
that would have a material adverse effect upon the Company’s financial condition or results of operations.  

Indemnities and Guarantees  

The  Company  has  made  certain  indemnities  and  guarantees,  under  which  it  may  be  required  to  make  payments  to  a  guaranteed  or 
indemnified  party,  in  relation  to  certain  actions  or  transactions.  The  Company  indemnifies  its  directors,  officers,  employees  and  agents,  as 
permitted under the laws of the States of California and Nevada. In connection with its facility lease, the Company has indemnified its lessor for 
certain claims arising from the use of the facility. The duration of the guarantees and indemnities varies, and is generally tied to the life of the 
agreement. These guarantees and indemnities do not provide for any limitation of the maximum potential future payments the Company could be 
obligated to make. Historically, the Company has not been obligated nor incurred any payments for these obligations and, therefore, no liabilities 
have been recorded for these indemnities and guarantees in the accompanying consolidated balance sheets.  

F-28 

   
    
 
   
 
   
  
CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 13.  Income Taxes  

Significant components of the Company’s deferred tax assets as of March 31, 2010 and 2009 are shown below:  

Deferred tax asset:  

Net operating loss carryforward   
Research credits  
Expenses recognized for granting of options and warrants     
Accrued expenses and reserves  
Valuation allowance     

2010  

2009  

  $ 

  $ 

10,938,000     $ 
24,000       
800,000       
104,000       
(11,866,000)       
—     $ 

5,031,000   
—   
862,000   
178,000   
(6,071,000)   
—   

Based on the weight of available evidence, the Company’s management has determined that it is not more likely than not that the net 
deferred  tax  assets  will  be  realized.  Therefore,  the  Company  has  recorded  a  full  valuation  allowance  against  the  net  deferred  tax  assets.  The 
Company’s income tax provision consists of state minimum taxes.  

The income tax provision differs from that computed using the federal statutory rate applied to income before taxes as follows:  

Computed tax benefit at federal statutory rate  
State tax, net of federal benefit    
Non deductible extinguishment of debt    
Permanent items and other  
Valuation allowance  

2010  
(1,920,000)     $ 
(645,000)       
—       
(3,226,400)       
5,793,000       
1,600     $ 

2009  
(5,679,000)   
1,000   
3,688,000   
1,036,600   
955,000   
1,600   

  $ 

  $ 

At March 31, 2010, the Company has federal and state net operating loss carry forwards of approximately $27,463,000 and $27,421, 
000  which  will  begin  to  expire  in  2019  and  2013,  respectively,  unless  previously  utilized.  At  March  31,  2010,  the  Company  has  federal  and 
California research and development tax credits of approximately $14,000 and $13,000, respectively.  The federal research tax credit begins to 
expire in 2026 unless previously utilized and the California research tax credit has no expiration date.  

Utilization of the net operating loss and research and development carry forwards might be subject to a substantial annual limitation due 
to ownership change limitations that may have occurred or that could occur in the future, as required by Section 382 of the Internal Revenue 
Code of 1986, as amended (the “Code”), as well as similar state and foreign provisions. These ownership changes may limit the amount of NOL 
and  R&D  credit  carryforwards  that  can  be  utilized  annually  to  offset  future  taxable  income  and  tax,  respectively.  In  general,  an  “ownership 
change”  as  defined  by  Section  382  of  the  Code  results  from  a  transaction  or  series  of  transactions  over  a  three-year  period  resulting  in  an 
ownership change of more than 50 percentage points of the outstanding stock of a company by certain stockholders or public groups.  Since the 
Company’s  formation,  the  Company  has  raised  capital  through  the  issuance  of  capital  stock  on  several  occasions  which,  combined  with  the 
purchasing stockholders’ subsequent disposition of those shares, may have resulted in such an ownership change, or could result in an ownership 
change in the future upon subsequent disposition.  

The  Company  has  not  completed  a  study  to  assess  whether  an  ownership  change  has  occurred.  If  the  Company  has  experienced  an 
ownership change, utilization of the NOL or R&D credit carryforwards would be subject to an annual limitation under Section 382 of the Code, 
which is determined by first multiplying the value of the Company’s stock at the time of the ownership change by the applicable long-term, tax-
exempt rate, and then could be subject to additional adjustments, as required.  Any limitation may result in expiration of a portion of the NOL or 
R&D credit carryforwards before utilization. Further, until a study is completed and any limitation is known, no amounts are being considered as 
an  uncertain  tax  position  or  disclosed  as  an  unrecognized  tax  benefit  under  FIN  48.   Due  to  the  existence  of  the  valuation  allowance,  future 
changes in the Company’s unrecognized tax benefits will not impact its effective tax rate.  Any carryforwards that will expire prior to utilization 
as a result of such limitations will be removed from deferred tax assets with a corresponding reduction of the valuation allowance.  

In  June  2006,  the  Financial  Accounting  Standards  Board  (“FASB”)  issued  Financial  Interpretation  (“  FIN  ”)  48,  “  Accounting  for 
Uncertainty in Income Taxes ,” (codified primarily in FASB ASC Topic 740, Income Taxes ) which clarifies the accounting for uncertainty in 

   
   
    
 
 
   
   
 
 
   
   
   
  
  
    
  
    
      
  
    
    
    
    
  
  
  
    
  
    
    
    
    
  
income taxes recognized in the financial statements in accordance with Statement of Financial Accounting Standards (“SFAS”) 109, “
Accounting  for  Income  Taxes  ,”  (codified  primarily  in  FASB  ASC  Topic  740,  Income  Taxes  ).  FIN  48  provides  that  a  tax  benefit  from  an 
uncertain  tax  position  may  be  recognized  when  it  is  more  likely  than  not  that  the  position  will  be  sustained  upon  examination,  including 
resolutions of any related appeals or litigation processes, based on the technical merits. Income tax positions must meet a more likely than not 
recognition  threshold.   The  Company  did  not  record  any  unrecognized  tax  benefits  upon  adoption  of  Accounting  for  Uncertainty  in  Income 
Taxes.  The Company's policy is to recognize interest and penalties that would be assessed in relation to the settlement value of unrecognized tax 
benefits as a component of income tax expense.  

F-29 

   
The Company does not have any unrecognized tax benefits that will significantly decrease or increase within 12 months of March 31, 

2010. The Company is subject taxation in the US and the state of California.  

As of March 31, 2010, the Company is no longer subject to U.S. federal examinations for year before 2006; and for California franchise 
and income tax examinations before 2005.  However, to the extent allowed by law, the taxing authorities may have the right to examine prior 
periods where net operating losses were generated and carried forward, and make adjustments up to the amount of the net operating loss carry 
forward amount.  The Company is not currently under examination by U.S. federal or state jurisdictions.  

Note 14.  Quarterly Results of Operations (unaudited)  

The following table sets forth a summary of our unaudited quarterly operating results for each of the last eight quarters in the period 
ended March 31, 2010. This data has been derived from our unaudited consolidated interim financial statements which, in our opinion, have been 
prepared on substantially the same basis as the audited financial statements contained elsewhere in this report and include all normal recurring 
adjustments necessary for a fair presentation of the financial information for the periods presented. These unaudited quarterly results should be 
read in conjunction with our financial statements and notes thereto included elsewhere in this report. The operating results in any quarter are not 
necessarily indicative of the results that may be expected for any future period (in thousands except earnings per share).  

Mar. 31, 

Dec. 31,  

Sept. 30, 

June 30,  

Mar. 31, 

Dec. 31,  

Sept. 30, 

 2010        

 2009        

 2009        

 2009        

 2009        

 2008        

 2008        

June 30, 
 2008     

(Unaudited)  

Quarter Ended  

  $ 

75      $ 

21      $ 

8      $ 

14      $ 

7      $ 

9      $ 

6      $ 

13   

259        

133        

177        

149        

127        

166        

135        

118   

(184 )      

(112 )      

(169 )      

(135 )      

(120 )      

(157 )      

(129 )      

(105 ) 

Revenues:  

Cost of revenues  

Gross loss  

Research and development  
Selling, general and administrative  

15        
1,114        

89        
690        

93        
779        

88        
729        

68        
497        

13        
551        

105        
780        

111   
560   

Total costs and expenses  

1,129        

779        

872        

817        

(565 )      

564        

885        

671   

Loss from operations  
Other income (expense), net  

(1,313 )      
747        

(891 )      
3,342        

(1,041 )      
(6,144 )      

(952 )      
602        

(685 )      
(4,774 )      

(721 )      
(733 )      

(1,014 )      
(555 )      

(776 ) 
(7,446 ) 

Income (loss) before income taxes  

  $ 

(566 )    $ 

2,451      $ 

(7,185 )    $ 

(350 )    $ 

(5,459 )    $  (1, 454 )    $ 

(1,569 )    $ 

(8,222 ) 

Income taxes  

—      

—      

2       

—       

1       

—       

—       

1   

Net income (loss)  

  $ 

(566 )   $ 

2,451     $ 

(7,187 )   $ 

(350 )   $ 

(5,460 )   $  (1, 454 )   $ 

(1,569 )   $ 

(8,223 ) 

Net income (loss) per common share:  
Basic  
Weighted average common shares 

outstanding:  

(0.09 )     

0.50       

(1.56 )     

(0.08 )     

(1.32 )     

(0.35 )     

(0.38 )     

(2.00 ) 

Basic  

Diluted  

6,242       

4,912       

4,615       

4,294       

4,149       

4,121       

4,117       

4,102   

6,242       

6,577       

4,615       

4,294       

4,149       

4,121       

4,117       

4,102   

F-30 

   
   
   
   
    
   
  
  
  
  
  
  
  
  
  
    
         
         
         
         
         
         
         
    
  
    
        
        
        
        
        
        
        
    
    
  
    
        
        
        
        
        
        
        
    
    
  
    
        
        
        
        
        
        
        
    
    
    
  
    
        
        
        
        
        
        
        
    
    
  
    
        
        
        
        
        
        
        
    
    
    
  
    
         
         
         
         
         
         
         
    
  
    
        
        
        
        
        
        
        
    
    
  
    
        
        
        
        
        
        
        
    
  
    
        
        
        
        
        
        
        
    
    
        
        
        
        
        
        
        
    
    
    
        
        
        
        
        
        
        
    
  
    
        
        
        
        
        
        
        
    
    
  
    
        
        
        
        
        
        
        
    
    
Note 15.   Subsequent Events  

On  April  1,  2010  the  Company  granted  to  Chris  Campbell,  Vice  President  of  Sales  a  stock  option  to  purchase  15,000  shares  of  the 
Company’s common stock at an exercise price of $2.00 per share valued at $27,963 as calculated using the Black Scholes option pricing model. 
The assumptions used under the Black-Scholes pricing model included: a risk free rate of 2.59%; volatility of 193%; an expected exercise term 
of 3.5 years; and no annual dividend rate.  These options vest beginning April 1, 2011 over 5 years.  

On  April  15,  2010,  the  Company  entered  into  office  service  agreements  with  Regus  Management  Group,  LLC  (Lessor)  for  five  (5) 
executive  offices  located  at  402  West  Broadway,  San  Diego,  CA  92101.  The  office  service  agreements  are  for  periods  ranging  from  3  to  7 
months ending October 31, 2010. The office service agreements require base lease payments of approximately $5,100 per month.  

In April 2010, the Company issued 13,636 shares of unrestricted common stock in lieu of fees paid to various consultants for services 
incurred in fiscal year 2010 pursuant to the Company’s Form S-8 filed on April 27, 2010.  These shares were issued at a value of $1.76 per share 
for a total cost of $24,000 which is included in accounts payable and selling, general and administrative as of and for the year ended March 31, 
2010.  

On May 11, 2010 the Company granted to Bret Bollinger, Vice President of Operations a fully vested stock option to purchase 20,000 
shares of the company’s common stock at an exercise  price of  $1.89  per share  for fiscal year 2010 annual  incentive. This  option  is valued at 
$34,034 as calculated using the Black Scholes option pricing model. The assumptions used under the Black-Scholes pricing model included: a 
risk free rate of 2.26%; volatility of 174%; an expected exercise term of 3.5 years; and no annual dividend rate.  This cost is included in selling, 
general and administrative for the year ended March 31, 2010.  

In  May  2010,  the  Company  granted  a  warrant  to  a  consultant  to  purchase  40,000  shares  of  common  stock  with  an  exercise  price  of 
$1.89  valued  at  $68,068  as  calculated  using  the  Black  Scholes  option  pricing  model.  The  assumptions  used  under  the  Black-Scholes  pricing 
model included: a risk free rate of 2.26%; volatility of 174%; an expected exercise term of 3.5 years; and no annual dividend rate. With 20,000 
shares vesting upon issuance and the remaining 20,000 shares vesting upon completion of certain key milestones to be developed by the CEO.  

In  May  2010,  we  obtained  a  key  man  life  insurance  policies  on  the  Company’s  Chief  Executive  Officer.  Annual  premiums  on  this 

policy total approximately $33,000.  

In June 2010, Company entered into the third amendment to the lease for its manufacturing and office space. The amendment extended 
the lease for sixty months commencing July 1, 2010 with a right to cancel the lease with a minimum of 120 day written notice at anytime as of 
December 31, 2012.  

F-31 

 
 
   
   
   
   
   
   
 
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report 

to be signed on its behalf by the undersigned, thereunto duly authorized.  

SIGNATURES  

Dated:  June 21, 2010  

CRYOPORT, INC.  

By: /s/ LARRY G. STAMBAUGH  
Larry G. Stambaugh,  
President & Chief Executive Officer, and Director  

POWER OF ATTORNEY  

KNOW  ALL  PERSONS  BY  THESE  PRESENTS,  that  each  person  whose  signature  appears  below  constitutes  and  appoints  Larry  G. 
Stambaugh,  President  and  Chief  Executive  Officer,  and  Catherine  M.  Doll,  Chief  Financial  Officer,  and  each  of  them,  his  true  and  lawful 
attorneys-in-fact  and  agents,  with  the  full  power  of  substitution  and  re-substitution,  for  him  and  in  his  name,  place  and  stead,  in  any  and  all 
capacities, to sign any amendments to this report, and to file the same, with exhibits thereto and other documents in connection therewith, with 
the Securities and Exchange Commission, granting unto each said attorney-in-fact and agent full power and authority to do and perform each and 
every  act  in  person,  hereby  ratifying  and  confirming  all  that  said  attorney-in-fact  and  agent,  or  either  of  them,  or  their  or  his  substitute  or 
substitutes, may lawfully do or cause to be done by virtue hereof.  

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the 
Registrant and in the capacities and on the dates indicated:  

Signature  

Capacity  

Date  

/s/ Larry G. Stambaugh  
Larry G. Stambaugh  

/s/ Catherine M. Doll  
Catherine M. Doll  

/s/ Carlton M. Johnson  
Carlton M. Johnson  

/s/ Adam Michelin  
Adam Michelin  

/s/ J. Hank Bonde  
J. Hank Bonde  

President & Chief Executive  
Officer (Principal Executive  
Officer), and Director  

Chief Financial Officer  
(Principal Financial and  
Principal Accounting Officer)  

Director  

Director  

Director  

June 21, 2010  

June 21, 2010  

June 21, 2010  

June 21, 2010  

June 21, 2010  

   
   
   
   
   
 
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
EXHIBIT INDEX  

Exhibit 

No.       

Description  

  1.1  

Form of Underwriting Agreement***  

  3.1  

  3.2  

  3.3  

  3.4  

Corporate Charter for G.T.5-Limited issued by the State of Nevada on March 15, 2005. Incorporated by reference to CryoPort’s 
Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Articles of Incorporation for G.T.5-Limited filed with the State of Nevada in May 25, 1990. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Amendment to Articles of Incorporation of G.T.5-Limited increasing the authorized shares of common stock from 5,000,000 to 
100,000,000 shares of common stock filed with the State of Nevada on October 12, 2004. Incorporated by reference to CryoPort’s 
Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Amendment to Articles of Incorporation changing the name of the corporation from G.T.5-Limited to CryoPort, Inc. filed with the 
State of Nevada on March 16, 2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated 
February 23, 2006.  

  3.4.1  

Amended and Restated Articles of Incorporation dated October 19, 2008. Incorporated by reference to CryoPort’s Current Report 
on Form 8-K filed October 19, 2007.  

  3.4.2        Certificate of Amendment to Articles of Incorporation filed with the State of Nevada on November 2, 2009.***  

  3.4.3  

  3.5  

  3.6  

  3.7  

  3.8  

  3.9  

  3.10  

  3.11  

  3.12  

  3.13  

Certificate of Amendment to Amended and Restated Articles of Incorporation. Incorporated by reference to CryoPort’s Current 
Report on Form 8-K filed February 5, 2010.  

Amended and Restated By-Laws of CryoPort, Inc. adopted by the Board of Directors on June 22, 2005 and amended by the 
Certificate of Amendment of Amended and Restated Bylaws of CryoPort, Inc. adopted by the Board of Directors on October 9, 
2009.***  

Articles of Incorporation of CryoPort Systems, Inc. filed with the State of California on December 11, 2000, including Corporate 
Charter for CryoPort Systems, Inc. issued by the State of California on December 13, 2000. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

By-Laws of CryoPort Systems, Inc. adopted by the Board of Directors on December 11, 2000. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

CryoPort, Inc. Stock Certificate Specimen. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 
dated February 23, 2006.  

Code of Conduct for CryoPort, Inc. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated 
February 23, 2006.  

Code of Ethics for Senior Officers of CryoPort, Inc. and subsidiaries. Incorporated by reference to CryoPort’s Registration 
Statement on Form 10-SB/A4 dated February 23, 2006.  

Statement of Policy on Insider Trading. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated 
February 23, 2006.  

CryoPort, Inc. Audit Committee Charter, under which the Audit Committee will operate, adopted by the Board of Directors on 
August 19, 2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

CryoPort Systems, Inc. 2002 Stock Incentive Plan adopted by the Board of Directors on October 1, 2002. Incorporated by reference 
to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

   
     
   
   
  
  
  
  
   
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
Exhibit 
No.  

  3.14  

  3.15  

  3.16  

Description  

Stock Option Agreement ISO—Specimen adopted by the Board of Directors on October 1, 2002. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Stock Option Agreement NSO—Specimen adopted by Board of Directors on October 1, 2002. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Warrant Agreement—Specimen adopted by the Board of Directors on October 1, 2002. Incorporated by reference to CryoPort’s 
Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

  3.17  

Patents and Trademarks  

  3.17.1  

  3.17.2  

  3.17.3  

  3.17.4  

  3.17.5  

  3.17.6  

  3.17.7  

  4.1  

  4.1.1  

  4.1.2  

CryoPort Systems, Inc. Patent #6,467,642 information sheet and Assignment to CryoPort Systems, Inc. document. On File with 
CryoPort.  

CryoPort Systems, Inc. Patent #6,119,465 information sheet and Assignment to CryoPort Systems, Inc. document. On File with 
CryoPort.  

CryoPort Systems, Inc. Patent #6,539,726 information sheet and Assignment to CryoPort Systems, Inc. document. On File with 
CryoPort.  

CryoPort Systems, Inc. Trademark #7,583,478,7 information sheet and Assignment to CryoPort Systems, Inc. document. On File 
with CryoPort.  

CryoPort Systems, Inc. Trademark #7,586,797,8 information sheet and Assignment to CryoPort Systems, Inc. document. On File 
with CryoPort.  

CryoPort Systems, Inc. Trademark #7,748,667,3 information sheet and Assignment to CryoPort Systems, Inc. document. On File 
with CryoPort.  

CryoPort Systems, Inc. Trademark #7,737,454,1 information sheet and Assignment to CryoPort Systems, Inc. document. On File 
with CryoPort.  

Form of Debenture—Original Issue Discount 8% Secured Convertible Debenture dated September 28, 2007. Incorporated by 
reference to CryoPort’s Registration Statement on Form SB-2 dated November 9, 2007.  

Amendment to Convertible Debenture dated February 19, 2008. Incorporated by reference to CryoPort’s Current Report on Form 
8-K dated March 7, 2008 and referred to as Exhibit 10.1.10.  

Amendment to Convertible Debenture dated April 30, 2008. CryoPort’s Current Report on  
Form 8-K dated April 30, 2008 and referred to as Exhibit 10.1.11.  

  4.1.2.1 

Annex to Amendment to Convertible Debenture dated April 30, 2008. CryoPort’s Current Report on Form 8-K dated April 30, 
2008 and referred to as Exhibit 10.1.11.1.  

  4.1.3  

  4.1.4  

  4.1.5  

Amendment to Convertible Debenture dated August 29, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-
K dated August 29, 2008.  

Amendment to Convertible Debenture effective January 27, 2009 and dated February 20, 2009. Incorporated by reference to 
CryoPort’s Current Report on Form 8-K dated February 19, 2009.  

Amendment to Debentures and Warrants with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified 
Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated September 1, 2009. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated September 17, 2009.  

  4.2  

Form of Common Stock Purchase Warrant dated September 28, 2007. Incorporated by reference to CryoPort’s Registration 

   
 
  
  
  
  
    
   
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
Statement on Form SB-2 dated November 9, 2007.  

   
   
    
  
Exhibit 

No.        Description  

  4.3  

  4.4  

  4.5  

Original Issue Discount 8% Secured Convertible Debenture dated May 30, 2008. Incorporated by reference to CryoPort’s Current 
Report on Form 8-K dated June 9, 2008.  

Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated 
June 9, 2008  

Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated 
June 9, 2008  

  4.6  

Form of Warrant and Warrant Certificate***  

10.1.1  

10.1.2  

10.1.3  

10.1.4  

10.1.5  

10.1.6  

10.1.7  

10.1.8  

10.2  

10.2.1  

10.3  

10.4  

Stock Exchange Agreement associated with the merger of G.T.5-Limited and CryoPort Systems, Inc. signed on March 15, 2005. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and D. Petreccia executed on August 26, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and J. Dell executed on September 1, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and M. Grossman executed on August 25, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and P. Mullens executed on September 2, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and R. Takahashi executed on August 25, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Exclusive and Representation Agreement between CryoPort Systems, Inc. and CryoPort Systems, Ltda. executed on August 9, 
2001. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006 and referred to 
as Exhibit 10.1.8.  

Secured Promissory Note and Loan Agreement between Ventana Group, LLC and CryoPort, Inc. dated May 12, 2006. Incorporated 
by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006 and referred to as Exhibit 10.1.9.  

Business Alliance Agreement dated April 27, 2007, by CryoPort, Inc. and American Biologistics Company LLC. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated April 27, 2007 and referred to as Exhibit 10.3.  

Corrected Business Alliance Agreement dated April 27, 2007, by CryoPort, Inc. and American Biologistics Company LLC. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K/A dated May 2, 2007 and referred to as Exhibit 10.3.1.  

Consultant Agreement dated April 18, 2007 between CryoPort, Inc. and Malone and Associates, LLC. Incorporated by reference to 
CryoPort’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 and referred to as Exhibit 10.4.  

Lease Agreement dated June 26, 2007 between CryoPort, Inc. and Viking Investors—Barents Sea LLC. Incorporated by reference 
to CryoPort’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 and referred to as Exhibit 10.5.  

 
   
   
  
  
  
  
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
Exhibit 

No.       

Description  

10.4.1  

Second Amendment To Lease: Renewal dated August 24, 2009, between CryoPort, Inc. and Viking Inventors-Barents Sea 
LLC.***  

10.5  

10.6  

10.7  

10.8  

10.9  

10.10  

10.11  

10.12  

10.13  

10.14  

10.15  

10.16  

10.17  

10.18  

10.19  

Securities Purchase Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on Form 
SB-2 dated November 9, 2007 and referred to as Exhibit 10.6.  

Registration Rights Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on Form 
SB-2 dated November 9, 2007 and referred to as Exhibit 10.7.  

Security Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on Form SB-2 
dated November 9, 2007 and referred to as Exhibit 10.8.  

Sitelet Agreement between FedEx Corporate Services, Inc. and CryoPort Systems, Inc. dated January 23, 2008. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated February 1, 2008 and referred to as Exhibit 10.9.  

Securities Purchase Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated 
June 9, 2008 and referred to as Exhibit 10.10.  

Registration Rights Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated 
June 9, 2008 and referred to as Exhibit 10.11.  

Waiver dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated June 9, 2008 and referred 
to as Exhibit 10.12.  

Security Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated June 9, 2008 
and referred to as Exhibit 10.13.  

Board of Directors Agreement between Larry G. Stambaugh and CryoPort, Inc. dated December 10, 2008. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated December 5, 2008 and referred to as Exhibit 10.15.  

Rental Agreement with FedEx Corporate Services and CryoPort, Inc. dated May 15, 2009 (CryoPort has filed a Confidential 
Treatment Request under Rule 24b-5 of the Exchange Act, for parts of this document). Incorporated by reference to CryoPort’s 
Annual Report on Form 10-K for the year ended March 31, 2009 and referred to as Exhibit 10.16.  

Settlement Agreement and Mutual Release with Dee Kelly and CryoPort, Inc. dated July 24, 2009. Incorporated by reference to 
CryoPort’s Current Report on Form 8-K dated July 20, 2009 and referred to as Exhibit 10.14.  

Consent, Waiver and Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified Strategy 
Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. and its subsidiary dated July 30, 2009. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated July 29, 2009 and referred to as Exhibit 10.15.  

Employment Agreement with Larry G. Stambaugh and CryoPort, Inc. dated August 1, 2009. Incorporated by reference to 
CryoPort’s Current Report dated August 21, 2009 and referred to as Exhibit 10.19.  

Letter Accepting Consulting Agreement dated October 1, 2007 with Carpe DM, Inc. and CryoPort, Inc. Incorporated by reference 
to CryoPort, Inc.’s Registration Statement on Form S-8 dated March 25, 2009 and referred to as Exhibit 10.1.  

Master Consulting and Engineering Services Agreement dated October 9, 2007 with KLATU Networks, LLC and CryoPort, Inc. 
Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated March 25, 2009 and referred to as Exhibit 
10.2  

 
   
   
  
  
  
  
   
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
Exhibit 

No.       

Description  

10.20  

10.21  

10.22  

10.23  

Investment Banker Termination Agreement dated April 6, 2009 with Bradley Woods & Co. Ltd., SEPA Capital Corp., Edward 
Fine, and CryoPort, Inc. Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated April 13, 2009 
and referred to as Exhibit 10.1.  

Attorney-Client Retainer Agreement with Gary Curtis Cannon and CryoPort, Inc. dated December 1, 2007. Incorporated by 
reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated June 11, 2009 and referred to as Exhibit 10.3.  

CryoPort, Inc., 2009 Stock Incentive Plan. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated October 9, 
2009 and referred to as Exhibit 10.21.  

CryoPort, Inc., Form Incentive Stock Option Award Agreement under the CryoPort, Inc., 2009 Stock Incentive Plan. Incorporated 
by reference to CryoPort’s Current Report on Form 8-K dated October 9, 2009 and referred to as Exhibit 10.22.  

10.24       

Form of Warrant to be entered into between the Registrant and Rodman & Renshaw, LLC.***  

23.1  

     Consent of Independent Registered Public Accounting Firm—KMJ Corbin & Company LLP.*  

24  

31.1 

31.2 

32.1 

32.2 

Power of Attorney***  

Certification of Chief Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002*  

Certification of Chief Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002*  

Certification Pursuant to U.S.C. §1350 of Chief Executive Officer.*  

Certification Pursuant to U.S.C. §1350 of Chief Financial Officer.*  

*  

Filed herewith  

**   To be filed by amendment  

***   Previously filed  

 
   
   
   
   
 
  
  
  
  
   
  
  
    
  
  
    
  
  
    
  
  
    
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
EXHIBIT 23.1 

Consent of Independent Registered Public Accounting Firm  

We consent to the incorporation by reference in the Registration Statements (Form S-1 No. 333-162350 and Form S-8 333-166327) of CryoPort, 
Inc.  of  our  report  dated  June  21,  2010,  with  respect  to  the  consolidated  financial  statements  and  schedule  of CryoPort, Inc.  (the  “Company”) 
included in the Annual Report (Form 10-K) (which report expresses an unqualified opinion and includes an explanatory paragraph relating to the 
substantial doubt about the Company’s ability to continue as a going concern) as of March 31, 2010 and 2009 and for the years then ended.  

/s/ 

KMJ  Corbin  & 

Company, LLP     

Costa Mesa, California  
June 21, 2010  

  
 
 
 
 
 
 
 
Certification of Chief Executive Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

EXHIBIT 31.1 

I, Larry G. Stambaugh, certify that:  

1.  I have reviewed this annual report on Form 10-K of CryoPort, Inc.;  

2.  Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make 
the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by 
this report;  

3.  Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects 
the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;  

4.  The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined 
in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 
15d-15(f)) for the registrant and have:  

a)       Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our 

supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others 
within those entities, particularly during the period in which this report is being prepared;  

b)     Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed 

under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements 
for external purposes in accordance with generally accepted accounting principles;  

c)      Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions 

about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and 

d)     Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s 
most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely 
to materially affect, the registrant’s internal control over financial reporting; and  

5.  The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, 
to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):  

a)             All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting 

which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and  

b)            Any fraud, whether or not material, that involves management or other employees who have a significant role in the 

registrant’s internal control over financial reporting.  

Dated: June 21, 2010  

Signed: /s/ LARRY G. STAMBAUGH  
Larry G. Stambaugh  
President & Chief Executive Officer, and Director  

  
 
 
   
   
   
   
   
 
   
   
   
   
   
   
 
  
Certification of Chief Financial Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

EXHIBIT 31.2 

I, Catherine M. Doll, certify that:  

1.  I have reviewed this annual report on Form 10-K of CryoPort, Inc.;  

2.  Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make 
the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by 
this report;  

3.  Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects 
the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;  

4.  The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined 
in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 
15d-15(f)) for the registrant and have:  

a)       Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our 

supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others 
within those entities, particularly during the period in which this report is being prepared;  

b)     Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed 

under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements 
for external purposes in accordance with generally accepted accounting principles;  

c)      Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions 

about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and 

d)     Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s 
most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely 
to materially affect, the registrant’s internal control over financial reporting; and  

5.  The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, 
to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):  

a)     All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which 

are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and  

b)    Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s 

internal control over financial reporting.  

Dated: June 21, 2010  

Signed: /s/ CATHERINE M. DOLL  
Catherine M. Doll  
Chief Financial Officer  

  
 
   
   
   
   
   
 
   
   
   
   
   
 
 
   
   
  
Certification  

EXHIBIT 32.1 

I, Larry Stambaugh., President and Chief Executive Officer of CryoPort Inc. (the “Company”), certify, pursuant to Rule 13(a)-14(b) or 

Rule 15(d)-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2010 (the “Report”) fully complies with the 
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the 
Company.  

Dated: June 21, 2010  

/s/ Larry G. Stambaugh  
Larry G. Stambaugh, Chairman,  
Chief Executive Officer  

  
   
   
   
   
   
   
  
Certification  

EXHIBIT 32.2 

I, Catherine M. Doll  Chief Financial Officer of CryoPort, INC. (the “Company”), certify, pursuant to Rule 13(a)-14(b) or Rule 15(d)-14

(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2010 (the “Report”) fully complies with the 
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the 
Company.  

Dated: June 21, 2010  

/ S / Catherine M. Doll  
Catherine M. Doll,  
Chief Financial Officer, Chief Accounting Officer