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Cryoport, Inc.

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FY2011 Annual Report · Cryoport, Inc.
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Table of Contents  

UNITED STATES  
SECURITIES AND EXCHANGE COMMISSION  
Washington, D.C. 20549  

FORM 10-K  

(Mark One)  
(cid:3)    

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES 
EXCHANGE ACT OF 1934 

For the fiscal year ended March 31, 2011  

OR  

(cid:1)    

TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES 
EXCHANGE ACT OF 1934 

For the transition period from ______ to ______  

Commission file number: 001-34632  

CRYOPORT, INC.  

(Exact name of Registrant as specified in its charter)  

Nevada  
(State or other jurisdiction of incorporation or organization) 

88-0313393  
(I.R.S. Employer Identification No.) 

20382 Barents Sea Circle, Lake Forest, California 
(Address of principal executive offices) 

92630 
(Zip Code) 

(949) 470-2300  
(Registrant’s telephone number, including area code) 

Securities registered pursuant to Section 12(b) of the Act: 

Title of Each Class  
Common Stock, $0.001 par value 

Name of Each Exchange on Which Registered  
OTC Market 

Securities registered pursuant to Section 12(g) of the Act:  
Common Stock, $0.001  
Warrants to Purchase Common Stock  

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes (cid:1) No (cid:3) 

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes (cid:1) No 
(cid:3)  

Indicate  by  check  mark  whether  the  registrant  (1) has  filed  all  reports  required  to  be  filed  by  Section 13  or  15(d)  of  the  Securities 
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), 
and (2) has been subject to such filing requirements for the past 90 days. Yes (cid:3) No (cid:1)  

Indicate  by  check  mark  whether  the  registrant  has  submitted  electronically  and  posted  on  its  corporate  Web  site,  if  any,  every 
Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during 
the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes (cid:1) No (cid:1)  

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405) is not contained herein, 
and  will  not  be  contained,  to  the  best  of  registrant’s  knowledge,  in  definitive  proxy  or  information  statements  incorporated  by 
reference in Part III of this Form 10-K or any amendment to this Form 10-K. (cid:3)  

Indicate  by  check  mark  whether  the  registrant  is  a  large  accelerated  filer,  an  accelerated  filer,  a  non-accelerated  filer  or  a  smaller 

  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
   
    
  
  
  
  
reporting company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of 
the Exchange Act. (check one):  

Large accelerated filer (cid:1)    

Accelerated filer (cid:1)    

Non-accelerated filer (cid:1)    

Smaller reporting company (cid:3) 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes (cid:1) No (cid:3)  

The aggregate market value of Common Stock held by non-affiliates as of September 30, 2010 was $9,761,382 (1)  

Number of shares of Common Stock outstanding as of June 10, 2011: 27,712,101  

DOCUMENTS INCORPORATED BY REFERENCE  

Part III  of  this  report  incorporates  certain  information  by reference  from  the registrant’s  proxy  statement  for  the  annual  meeting  of 
stockholders, which proxy statement will be filed no later than 120 days after the close of the registrant’s fiscal year ended March 31, 
2010.  

(1)    Excludes  5,881  shares  of  common  stock  held  by  directors  and  officers,  and  any  stockholder  whose  ownership  exceeds  five 

percent of the shares outstanding as of September 30, 2010.  

   
   
  
  
  
  
  
  
  
  
     
  
  
CRYOPORT, INC.  

Fiscal Year 2011 10-K Annual Report  

Table of Contents  

PART I  

Item 1 Business  

Item 1A Risk Factors  

Item 1B Unresolved Staff Comments  

Item 2 Properties  

Item 3 Legal Proceedings  

Item 4 [Removed and Reserved]  

Item 5 Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity 

PART II  

Securities  

Item 6 Selected Financial Data  

Item 7 Management’s Discussion and Analysis of Financial Condition and Results of Operations  

Item 7A Quantitative and Qualitative Disclosures About Market Risk  

Item 8 Financial Statements and Supplementary Data  

Item 9 Changes in and Disagreements with Accountants on Accounting and Financial Disclosures  

Item 9A Controls and Procedures  

Item 9B Other Information  

Item 10 Directors, Executive Officers and Corporate Governance  

Item 11 Executive Compensation  

PART III  

Item 12 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters  

Item 13 Certain Relationships and Related Transactions, and Director Independence  

Item 14 Principal Accountant Fees and Services  

Item 15 Exhibits and Consolidated Financial Statement  

PART IV  

Schedules  

Signatures  

  Exhibit 21 
  Exhibit 23.1 
  Exhibit 31.1 
  Exhibit 31.2 
  Exhibit 32.1 

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  Exhibit 32.2 

NOTE REGARDING REVERSE STOCK SPLIT  

On February 5, 2010, we filed a Certificate of Amendment to our Articles of Incorporation with the Secretary of State of 
the State of Nevada to affect a reverse split of our common stock at a ratio of ten for one. All historical share and per share amounts 
have been adjusted to reflect the reverse stock split.  

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PART I  

In  this  Annual  Report,  the  terms  “we”,  “us”,  “our”,  “Company”  and  “CryoPort”  refer  to  CryoPort,  Inc.,  and  our  wholly  owned 
subsidiary, CryoPort Systems, Inc. This Annual Report contains forward-looking statements that involve risks and uncertainties. The 
inclusion of forward-looking statements should not be regarded as a representation by us or any other person that the objectives or 
plans  will  be  achieved  because  our  actual  results  may  differ  materially  from  any  forward-looking  statement.  The  words  “may,”
“should,”  “plans,”  “believe,”  “anticipate,”  “estimate,”  “expect,”  their  opposites  and  similar  expressions  are  intended  to  identify 
forward-looking  statements,  but the  absence  of these words does not necessarily  mean  that a statement is not forward-looking. We 
caution readers that such statements are not guarantees of future performance or events and are subject to a number of factors that may 
tend  to influence  the  accuracy  of  the  statements,  including  but  not  limited  to,  those  risk  factors  outlined  in  the  section  titled  “Risk 
Factors” as well as those discussed elsewhere in this Annual Report. You should not unduly rely on these forward-looking statements, 
which speak only as of the date of this Annual Report. We undertake no obligation to publicly revise any forward-looking statement to 
reflect circumstances or events after the date of this Annual Report or to reflect the occurrence of unanticipated events. You should, 
however,  review  the  factors  and  risks  we  describe  in  the  reports  that  we  file  from  time  to  time  with  the  Securities  and  Exchange 
Commission (“SEC”) after the date of this Annual Report.  

In addition, we own or have rights to the registered trademark CryoPort ® (both alone and with a design logo) and CryoPort Express ® 
(both alone and with a design logo). All other Company names, registered trademarks, trademarks and service marks included in this 
Annual Report are trademarks, registered trademarks, service marks or trade names of their respective owners.  

Item 1. 

  BUSINESS  

Overview  

We are a provider of an innovative cold chain frozen shipping system dedicated to providing superior, affordable cryogenic 
shipping solutions that ensure the safety, status and temperature, of high value, temperature sensitive materials. We have developed 
cost effective reusable cryogenic transport containers (referred to as “shippers”) capable of transporting biological, environmental and 
other temperature sensitive materials at temperatures below minus 150° Celsius. These dry vapor shippers and shipping system are 
one of the first significant alternatives to dry ice shipping and achieve 10-plus day holding times compared to one to two day holding 
times with dry ice.  

Our  value  proposition  comes  from  both  providing  safe  transportation  with  an  environmentally  friendly,  long  lasting 
shipper, and through our value added services that offer a simple hassle-free solution for our customers. These value-added services 
include an internet-based web portal that enables the customer to initiate scheduling, shipping and tracking of the progress and status 
of a shipment, and provides in-transit temperature and custody transfer monitoring services of the shipper. The CryoPort service also 
provides a fully ready charged shipper containing all freight bills, customs documents and regulatory paperwork for the entire journey 
of the shipper to our customers at their pickup and delivery locations.  

Our principal focus has been the further development and commercial launch of CryoPort Express ® Portal, an innovative 
IT  solution  for  shipping  and  tracking  high-value  specimens  through  overnight  shipping  companies,  and  our  CryoPort  Express  ® 
Shipper, a dry vapor cryogenic shipper for the transport of biological and pharmaceutical materials. A dry vapor cryogenic shipper is a 
container that uses liquid nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide 
storage  temperatures  below  minus  150°  Celsius.  The  dry  vapor  shipper  is  designed  using  innovative,  proprietary,  and  patented 
technology  which  prevents  spillage  of  liquid  nitrogen  and  pressure  build  up  as  the  liquid  nitrogen  evaporates.  A  proprietary  foam 
retention system is employed to ensure that liquid nitrogen stays inside the vacuum container, even when placed upside-down or on its 
side, as is often the case when in the custody of a shipping company. Biological specimens are stored in a specimen chamber, referred 
to  as  a  “well”  inside  the  container  and  refrigeration  is  provided  by  harmless  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen 
entrapped within the foam retention system surrounding the well. Biological specimens transported using our cryogenic shipper can 
include  clinical  samples,  diagnostics,  live  cell  pharmaceutical  products  (such  as  cancer  vaccines,  semen  and  embryos,  infectious 
substances) and other items that require and/or are protected through continuous exposure to frozen or cryogenic temperatures.  

During our early years, our limited revenue was derived from the sale of our reusable product line. Our current business 
plan focuses on per-use leasing of the shipping container and added-value services that will be used by us to provide an end-to-end 
and cost-optimized shipping solution to life  science companies moving pharmaceutical and biological samples in clinical  trials  and 
pharmaceutical distribution.  

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The  Company  entered  into  its  first  strategic  relationship  with  a  global  courier  on  January 13,  2010  when  it  signed  an 
agreement with Federal Express Corporation (“FedEx”) pursuant to which the Company leases to FedEx such number of its cryogenic 
shippers that FedEx, from time to time, orders for FedEx’s customers. Under this agreement, FedEx has the right to and shall, on a 
non-exclusive basis, promote market and sell transportation of the Company’s shippers and its related value-added goods and services, 
such as its data logger, web portal and planned CryoPort Express ® Smart Pak System. On January 24, 2011 we announced that FedEx 
had  launched  its  deep  frozen  shipping  solution  using  our  CryoPort  Express  ®  Dry  Shipper.  On  September 2,  2010,  the  Company 
entered  into  an  agreement  with  DHL  Express  (USA),  Inc.  (“DHL”)  that  gives  DHL  life  science  customers  direct  access  to  the 
Company’s web-based order entry and tracking portal to order the CryoPort Express  ® Shipper and receive preferred DHL shipping 
rates.  The  agreement  covers  DHL  shipping  discounts  that  may  be  used  to  support  the  Company’s  customers  using  the  CryoPort 
Express  ®  shipping  solution.  In  connection  with  the  agreement,  the  Company  has  integrated  its  proprietary  web  portal  to  DHL’s 
tracking  and  billing  systems.  DHL  life  science  customers  now  have  a  seamless  way  of  shipping  their  critical  biological  material 
worldwide. The IT integration with DHL was completed during the Company’s fourth quarter of fiscal year 2011.  

We  are  a  Nevada  corporation  originally  incorporated  under  the  name  G.T.5-Limited  (“GT5”)  on  May 25,  1990.  In 
connection  with  a  Share  Exchange  Agreement,  on  March 15,  2005  we  changed  our  name  to  CryoPort,  Inc.  and  acquired  all  of  the 
issued and outstanding shares of common stock of CryoPort Systems, Inc., a California corporation, in exchange for 2,410,811 shares 
of our common stock (which represented approximately 81% of the total issued and outstanding shares of common stock following 
the close of the transaction). CryoPort Systems, Inc., which was originally formed in 1999 as a California limited liability company, 
and subsequently reorganized into a California corporation on December 11, 2000, remains the operating company under CryoPort, 
Inc. Our principal executive offices are located at 20382 Barents Sea Circle, Lake Forest, California 92630. The telephone number of 
our principal executive offices is (949) 470-2300, and our main corporate website is www.cryoport.com. The information on, or that 
can be accessed through, our website is not part of this Annual Report.  

Our Products and Pipeline  

Our product offering and service offering consists of our CryoPort Express ® Shippers, reusable dry vapor shippers, the web 
portal  allowing  ease  of  entry  and  our  Smart  Pak  data  logger,  a  temperature  monitoring  system  (which,  together  with  our  CryoPort 
Express ® Shippers, comprise our new business model referred to as the CryoPort Express ® System) and a containment bag which is 
used in connection with the shipment of infectious or dangerous goods using the CryoPort Express ® Shipper.  

The CryoPort Express ® Shippers 

Our CryoPort Express ® Shippers are cryogenic dry vapor shippers capable of maintaining cryogenic temperatures of minus 
150° Celsius or below for a period of 10 or more days. A dry cryogenic shipper is a device that uses liquid nitrogen contained inside a 
vacuum  insulated  bottle  which  serves  as  a  refrigerant  to  provide  storage  temperatures  below  minus  150°  Celsius.  Our  CryoPort 
Express  ®  shipper  is  designed  to  ensure  that  there  is  no  pressure  build  up  as  the  liquid  nitrogen  evaporates  or  spillage  of  liquid 
nitrogen.  We  have  developed  a  proprietary  foam  retention system  to ensure  that  liquid  nitrogen  stays  inside  the  vacuum  container, 
which allows the shipper to be designated as a dry shipper meeting International Air Transport Association (“IATA”) requirements. 
Biological  or  pharmaceutical  specimens  are  stored  in  a  specimen  chamber,  referred  to  as  a  “well”,  inside  the  container  and 
refrigeration  is  provided  by  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen  entrapped  within  the  foam  retention  system. 
Specimens  that  may  be  transported  using  our  cryogenic  shipper  include  live  cell  pharmaceutical  products  such  as  cancer  vaccines, 
diagnostic  materials,  semen  and  embryos,  infectious  substances  and  other  items  that  require  continuous  exposure  to  frozen  or 
cryogenic temperatures (e.g., temperatures below minus 150° Celsius).  

The technology underlying the CryoPort Express  ® Shipper was developed by modifying and advancing technology from 
our first generation of reusable cryogenic dry shippers. While our CryoPort Express ® Shippers share many of the characteristics and 
basic design details of our earlier shippers, we are manufacturing our CryoPort Express  ® Shippers from alternative, lower cost and 
lower weight materials, which will reduce overall operating costs. We maintain ongoing development efforts related to our shippers 
which  are  principally  focused  on  material  properties,  particularly  those  properties  related  to  the  low  temperature  requirement,  the 
vacuum retention characteristics, such as the permeability of the materials, and lower cost and lower weight materials in an effort to 
meet  the  market  needs  for  achieving  a  lower  cost  frozen  and  cryogenic  shipping  solution.  Other  advances  additional  to  the 
development work on the cryogenic container include both an improved liquid nitrogen retention system and a secondary protective, 
spill proof packaging system. This secondary system, outer packaging has a low cost that lends itself to disposability, and it is made of 
recyclable  materials.  Further,  it  adds  an  additional  liquid  nitrogen retention capability  to  further  assure  compliance with IATA  and 
ICAO regulations that prohibit egress of liquid nitrogen from the shipping package. IACO stands for the International Civil Aviation 
Organization, which is a United Nations organization that develops regulations for the safe transport of dangerous goods by air.  

Our CryoPort Express ® Shippers are lightweight, low-cost, re-usable dry vapor liquid nitrogen storage containers that we 
believe combine the best features of packaging, cryogenics and high vacuum technology. A CryoPort Express ® Shipper is composed 
of  an  aluminum  metallic  dewar  flask,  with  a  well  for  holding  the  biological  material  in  the  inner  chamber.  The  dewar  flask,  or 
“thermos bottle,” is an example of a practical device in which the conduction, convection and radiation of heat are reduced as much as 
possible. The inner chamber of the shipper is surrounded by a high surface, low-density open cell plastic foam material which retains 
the liquid nitrogen in-situ by absorption, adsorption and surface tension. Absorption is defined as the taking up of matter in bulk by 
other matter, as in the dissolving of a gas by a liquid, whereas adsorption is the surface retention of solid, liquid or gas molecules, 
atoms  or  ions  by  a  solid  or  liquid.  This  material  absorbs  liquid  nitrogen  several  times  faster  than  currently  used  materials,  while 

 
providing the shipper with a hold time and capacity to transport biological materials safely and conveniently. The annular 
space between the inner and outer dewar chambers is evacuated to a very high vacuum (10-6 Torr). The specimen-holding chamber 
has a primary cap to enclose the specimens, and a removable and replaceable secondary cap to further enclose the specimen-holding 
container  and  to  contain  the  liquid  nitrogen.  The  entire  dewar  vessel  is  then  wrapped  in  a  plurality  of  insulating  and  cushioning 
materials and placed in a disposable outer packaging made of recyclable material.  

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We believe the CryoPort solution is the best and most cost effective solution available in the market that satisfies customer 
needs  and  regulatory  requirements  relating  to  the  shipment  of  temperature-critical,  frozen  and  refrigerated  transport  of  biological 
materials,  such  as  the  pharmaceutical  clinical  trials,  gene  biotechnology,  infectious  materials  handling,  and  animal  and  human 
reproduction markets. Due to our proprietary technology and innovative design, our shippers are less prone to losing functional hold 
time when  not  kept  in  an  upright  position  than  the  competing  products  because  such  proprietary  technology  and  innovative  design 
prevent  the  spilling  or  leakage  of  the  liquid  nitrogen  when  the  container  is  tipped  or  on  its  side  which  would  adversely  affect  the 
functional hold time of the container.  

An important feature of the CryoPort Express ® Shippers is their compliance with the stringent packaging requirements of 
IATA  Packing  Instructions  602  and  650,  respectively.  These  instructions  include  the  internal  pressure  (hydraulic) and  drop 
performance requirements.  

The CryoPort Express ® System 

The CryoPort Express ® System comprises the CryoPort Express ® Shipper , the CryoPort Express ® Smart Pak data logger, 
CryoPort  Express  ®  Portal,  which  programmatically  manages  order  entry  and  all  aspects  of  shipping  operations,  and  CryoPort 
Express  ® Analytics, which monitors shipment performance metrics and evaluates temperature-monitoring data collected by the data 
logger during shipment. The CryoPort Express ® System is focused on improving the reliability of frozen shipping while reducing the 
customers’ overall operating costs. This is accomplished by providing a complete end-to-end solution for the transport and monitoring 
of frozen or cryogenically preserved biological or pharmaceutical materials shipped though overnight shipping companies. Certain of 
the intellectual property underlying the CryoPort Express  ® System, (other than that related to the CryoPort Express  ® Shipper) has 
been, and continues to be, developed under a contract with an outside software development company, with the underlying technology 
licensed to us for exclusive use in our field of use.  

CryoPort Express ® Portal 

The  CryoPort  Express  ®  Portal  is  used  by  CryoPort,  our  customers  and  our  business  partners  to  automate  the  entry  of 
orders, prepare customs documentation and to facilitate status and location monitoring of shipped orders while in transit. It is used by 
CryoPort  to  manage  shipping  operations  and  to  reduce  administrative  costs  typically  provisioned  through  manual  labor  relating  to 
order-entry, order processing, preparation of shipping documents and back-office accounting. It is also used to support the high level 
of customer service expected by the industry. Certain features of the CryoPort Express  ® Portal reduce operating costs and facilitate 
the scaling of CryoPort’s business, but more importantly they offer significant value to the customer in terms of cost avoidance and 
risk mitigation. Examples of these features include automation of order entry; development of Key Performance Indicators (“KPI”) to 
support  our  efforts  for  continuous  process  improvements  in  our  business,  and  programmatic  exception  monitoring  to  detect  and 
sometimes anticipate delays in the shipping process, often before the customer or the shipping company becomes aware of them. In 
the  future we  will  add  rate and  mode optimization  and  in-transit monitoring of  temperature, location  and  state  of  health  (discussed 
below), via wireless communications.  

The CryoPort Express ® Portal also serves as the communications nerve center for the management, collection and analysis 
of Smart Pak data harvested from Smart Pak data loggers in the field. Data is converted into pre-designed reports containing valuable 
and  often  actionable  information  that  becomes  the  quality  control  standard  or  “pedigree”  of  the  shipment.  This  information  can  be 
utilized by CryoPort to provide valuable feedback to the customer relating to cryogenic shipping.  

The CryoPort Express ® Smart Pak 

Temperature monitoring is a high value feature from our customers’ perspective as it is an effective and reliable method to 
determine that the shipment materials were not damaged or degraded during shipment due to temperature fluctuations. Phase II of our 
Smart  Pak  System  which  is  a  self-contained  automated  data  logger  capable  of  recording  the  internal  and  external  temperatures  of 
samples shipped in our CryoPort Express ® Shipper was launched in fiscal year 2010.  

Phase III of our Smart Pak System is anticipated to launch in fiscal year 2012, and consists of adding a smart chip to each 
shipper with wireless connectivity to enable our customers to monitor a shipper’s location, specimen temperature and overall state of 
health  via  our  web  portal.  A  key  feature  of  the  Phase  III  product  is  automatic  downloading  of  data  which  requires  no  customer 
intervention.  

CryoPort Express ® Analytics 

Our  continued  development  of  the  CryoPort  Express  ®  Portal  is  a  strategic  element  of  our  business  strategy  and  the 
CryoPort Express ® Portal system has been designed to support planned future features with this thought in mind. Analytics is a term 
used  by  IT  professionals  to  refer  to  performance  benchmarks  or  Key  Performance  Indicators  (KPI’s)  that  management  utilizes  to 
measure performance against desired standards. Examples include time-based metrics for order processing time and on-time deliveries 
by  our  shipping  partners,  as  well  as  profiling  shipping  lanes  to  determine  average  transit  times  and  predicting  an  exception  if  a 
shipment  is  taking  longer  than  it  should  based  on  historical  metrics.  The  analytical  results  will  be  utilized  by  CryoPort  to  render 
consultative customer services.  

Biological Material Holders  

 
 
 
 
We  have  also  developed  a  patented  containment  bag  which  is  used  in  connection  with  the  shipment  of  infectious  or 
dangerous  goods  using  the  CryoPort  Express  ®  Shipper. Up  to  five  vials,  watertight  primary  receptacles  are placed  onto  aluminum 
holders and up to fifteen holders (75 vials) are placed into an absorbent pouch which is designed to absorb the entire contents of all the 
vials  in  the  event  of  leakage.  This  pouch  containing  up  to  75  vials  is  then  placed  in  a  watertight  secondary  packaging  Tyvek  bag 
capable of withstanding cryogenic temperatures, and then sealed. This bag is then placed into the well of the cryogenic shipper.  

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Other Product Candidates and Development Activities  

We are continuing our research and development efforts which are expected to lead to the introduction of additional dry 
vapor shippers, including larger and smaller size units constructed of lower cost materials and utilizing high volume manufacturing 
methods. We are also exploring the use of alternative phase change materials in place of liquid nitrogen in order to seek entry into the 
ambient temperature and chilled (2° to 8° Celsius) shipping markets.  

Government Regulation  

The shipping of diagnostic specimens, infectious substances and dangerous goods, whether via air or ground, falls under the 
jurisdiction of many states, federal and international agencies. The quality of the containers, packaging materials and insulation that 
protect a specimen determine whether or not it will arrive in a usable condition. Many of the regulations for transporting dangerous 
goods in the United States are determined by international rules formulated under the auspices of the United Nations. For example, the 
ICAO is the United Nations organization that develops regulations (Technical Instructions) for the safe transport of dangerous goods 
by  air.  If  shipment  is  by  air,  compliance  with  the  rules  established  by  IATA  is  required.  IATA  is  a  trade  association  made  up  of 
airlines and air cargo couriers that publishes annual editions of the IATA Dangerous Goods Regulations. These regulations interpret 
and add to the ICAO Technical Instructions to reflect industry practices. Additionally, the CDC has regulations (published in the Code 
of Federal Regulations) for interstate shipping of specimens, and OSHA also addresses the safe handling of Class 6.2 Substances. Our 
CryoPort Express  ® Shipper meets Packing Instructions 602 and 650 and is certified for the shipment of Class 6.2 Dangerous Goods 
per the requirements of the ICAO Technical Instructions for the Safe Transport of Dangerous Goods by Air and IATA. Our present 
and planned future versions of the CryoPort Smart Pak data logger will likely be subject to regulation by FAA, FCC, FDA, IATA and 
possibly other agencies which may be difficult to determine on a global basis.  

We  are  also  subject  to  numerous  other  federal,  state  and  local  laws  relating  to  such  matters  as  safe  working  conditions, 
manufacturing practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. 
We may incur significant costs to comply with such laws and regulations now or in the future.  

Manufacturing and Raw Materials  

Manufacturing.  The component parts for  our products  are  primarily manufactured at  third party manufacturing facilities. 
We also have a warehouse at our corporate offices in Lake Forest, California, where we are capable of manufacturing certain parts and 
fully assemble our products. Most of the components that we use in the manufacture of our products are available from more than one 
qualified  supplier.  For  some  components,  however,  there  are  relatively  few  alternate  sources  of  supply  and  the  establishment  of 
additional or replacement suppliers may not be accomplished immediately, however, we have identified alternate qualified suppliers 
which we believe could replace existing suppliers. Should this occur, we believe that with our current level of dewars and production 
rate we have enough to cover a four to six week gap in maximum disruption of production. There are no specific agreements with any 
manufacturer nor are there any long term commitments to any manufacturer. We believe that most of the manufactures currently used 
by us could be replaced within a short period of time as none have a proprietary component or a substantial capital investment specific 
to our products.  

Our  production  and  manufacturing  process  incorporates  innovative  technologies  developed  for  aerospace  and  other 
industries which are cost effective, easier to use and more functional than the traditional dry ice devices and other methods currently 
used for the shipment of temperature-sensitive materials. Our manufacturing process uses non-hazardous cleaning solutions which are 
provided and disposed of by a supplier approved by the Environmental Protection Agency (the “EPA”). EPA compliance costs for us 
are therefore negligible.  

Raw Materials. Various common raw materials are used in the manufacture of our products and in the development of our 
technologies.  These  raw  materials  are  generally  available  from  several  alternate  distributors  and  manufactures.  We  have  not 
experienced  any  significant  difficulty  in  obtaining  these  raw  materials  and  we  do  not  consider  raw  material  availability  to  be  a 
significant factor in our business.  

Patents and Proprietary Rights  

In order to remain competitive, we must develop and maintain protection on the proprietary aspects of our technologies. We 
rely on a combination of patents, copyrights, trademarks, trade secret laws and confidentiality agreements to protect our intellectual 
property rights. We currently own four registered United States trademarks and three issued United States patents primarily covering 
various  aspects  of  our  products.  In  addition,  we  have  filed  a  patent  application  for  various  aspects  of  our  shipper  and  web-portal, 
which  includes,  in part, various  aspects of our  business  model  referred  to as  the CryoPort Express  ®  System, and we  intend  to  file 
additional  patent  applications  to  strengthen  our  intellectual  property  rights.  The  technology  covered  by  the  above  indicated  issued 
patents relates to matters specific to the use of liquid nitrogen dewars in connection with the shipment of biological materials. The 
concepts  include  those  of  disposability,  package  configuration details,  liquid  nitrogen retention systems,  systems  related to  thermal 
performance, systems related to packaging integrity, and matters generally relevant to the containment of liquid nitrogen. Similarly, 
the trademarks mentioned relate to the cryogenic temperature shipping activity. Issued patents and trademarks currently owned by us 
include:  

Type: 

No. 

Issued 

Expiration 

  
  
    
    
    
    
    
  
  
    
  
Patent  
Patent  
Patent  
Trademark  
Trademark  
Trademark  
Trademark  

   6,467,642      Oct. 22, 2002    Oct. 21, 2022 
Sep. 18, 2020 
Sep. 19, 2000   
   6,119,465     
Apr. 1, 2003     Mar 31, 2023 
   6,539,726     
   7,583,478,7     
Oct. 9, 2002    
   7,586,797,8      Apr. 16, 2002   
Feb. 3, 2009    
   7,748,667,3     
   7,737,451,1      Mar. 17, 2009   

N/A 
N/A 
N/A 
N/A 

4  

   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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Our success depends to a significant degree upon our ability to develop proprietary products and technologies and to obtain 
patent  coverage  for  these  products  and  technologies.  We  intend  to  file  trademark  and  patent  applications  covering  any  newly 
developed  products,  methods  and  technologies.  However,  there  can  be  no  guarantee  that  any  of  our  pending  or  future  filed 
applications will be issued as patents. There can be no guarantee that the U.S. Patent and Trademark Office or some third party will 
not initiate an interference proceeding involving any of our pending applications or issued patents. Finally, there can be no guarantee 
that our issued patents or future issued patents, if any, will provide adequate protection from competition.  

Patents  provide  some  degree  of  protection  for  our  proprietary  technology.  However,  the  pursuit  and  assertion  of  patent 
rights involve complex legal and factual determinations and, therefore, are characterized by significant uncertainty. In addition, the 
laws governing patent issuance and the scope of patent coverage continue to evolve. Moreover, the patent rights we possess or are 
pursuing generally cover our technologies to varying degrees. As a result, we cannot ensure that patents will issue from any of our 
patent  applications,  or  that  any  of  its  issued  patents  will  offer  meaningful  protection.  In  addition,  our  issued  patents  may  be 
successfully  challenged,  invalidated,  circumvented  or  rendered  unenforceable  so  that  our  patent  rights  may  not  create  an  effective 
barrier to competition. Moreover, the laws of some foreign countries may not protect our proprietary rights to the same extent, as do 
the laws of the United States. There can be no assurance that any patents issued to us will provide a legal basis for establishing an 
exclusive market for our products or provide us with any competitive advantages, or that patents of others will not have an adverse 
effect on our ability to do business or to continue to use our technologies freely.  

We may be subject to third parties filing claims that our technologies or products infringe on their intellectual property. We 
cannot predict whether third parties will assert such claims against us or whether those claims will hurt our business. If we are forced 
to defend against such claims, regardless of their merit, we may face costly litigation and diversion of management’s attention and 
resources.  As  a  result  of  any  such  disputes,  we  may  have  to  develop,  at  a  substantial  cost,  non-infringing  technology  or  enter  into 
licensing  agreements.  These  agreements  may  be  unavailable  on  terms  acceptable  to  it,  or  at  all,  which  could  seriously  harm  our 
business or financial condition.  

We  also  rely  on  trade  secret  protection  of  our  intellectual  property.  We  attempt  to  protect  trade  secrets  by  entering  into 
confidentiality  agreements  with  third  parties,  employees  and  consultants,  although,  in  the  past,  we  have  not  always  obtained  such 
agreements. It is possible that these agreements may be breached, invalidated or rendered unenforceable, and if so, our trade secrets 
could  be  disclosed  to  our  competitors.  Despite  the  measures  we  have  taken  to  protect  our  intellectual  property,  parties  to  such 
agreements may breach confidentiality provisions in our contracts or infringe or misappropriate our patents, copyrights, trademarks, 
trade secrets and other proprietary rights. In addition, third parties may independently discover or invent competitive technologies, or 
reverse engineer our trade secrets or other technology. Therefore, the measures we are taking to protect our proprietary technology 
may not be adequate.  

Customers and Distribution  

As a result of growing globalization, including with respect to such areas as life science clinical trials and distribution of 
pharmaceutical products, the requirement for effective solutions for keeping certain clinical samples and pharmaceutical products at 
frozen temperatures takes on added significance due to extended shipping times, custom delays and logistics challenges. Today, such 
goods are traditionally shipped in styrofoam cardboard insulated containers packed with dry ice, gel/freezer packs or a combination 
thereof.  The  current  dry  ice  solutions  have  limitations  that  severely  limit  their  effective  and  efficient  use  for  both  short  and  long-
distances (e.g., international). Conventional dry ice shipments often require labor intensive “re-icing” operations resulting in higher 
labor and shipping costs.  

We believe our patented cryogenic shippers make us well positioned to take advantage of the growing demand for effective 
and  efficient  international  transport  of  temperature  sensitive  materials  resulting  from  continued  globalization.  Of  particular 
significance is the trend within the pharmaceutical and biotechnology industries toward globalization. We believe this presents a new 
and unique opportunity for pharmaceutical companies, particularly early or developmental stage companies, to conduct some of their 
clinical trials in foreign countries where the cost may be cheaper and/or because the foreign countries significantly larger population 
provides a larger pool of potential patients suffering from the indication that the drug candidate is being designed to treat. We also 
plan to provide domestic shipping solutions in situations and regions where there is a high priority placed on maintaining the integrity 
of materials shipped at cryogenic temperatures and where we can be cost effective.  

To date, most of our customers have been in the pharmaceutical or medical industries. As we initially focus our efforts to 
increase revenues, we believe that the primary target customers for our CryoPort Express ® System are concentrated in the following 
markets, for the following reasons:  

• 

• 

• 

• 

• 

  Pharmaceutical clinical trials / contract research organizations;  

  Gene biotechnology;  

  Transport of infectious materials and dangerous goods;  

  Pharmaceutical distribution; and  

  Fertility clinics/artificial insemination.  

  
  
  
  
  
  
  
  
  
Pharmaceutical Clinical Trials. Every pharmaceutical company developing a new drug must be approved by the FDA who 
conducts clinical trials to, among other things, test the safety and efficacy of the potential new drug. Presently, a significant amount of 
clinical  trial  activity  is  managed  by  a  number  of  large  Clinical  Research  Organizations  (“CROs”).  Due  to  the  growing  downsizing 
trend in the pharmaceutical industry, CROs are going to obtain an increasing share of the clinical trial market.  

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In connection with the clinical trials, due to globalization the companies may enroll patients from all over the world who 
regularly submit a blood or other specimen at the local hospital, doctor’s office or laboratory. These samples are then sent to specified 
testing  laboratories,  which  may  be  local  or  in  another  country.  The  testing  laboratories  will  typically  set  the  requirements  for  the 
storage and shipment of blood specimens. In addition, several of the drugs used by the patients require frozen shipping to the sites of 
the  clinical  trials.  While  both  domestic  and  international  shipping  of  these  specimens  is  accomplished  using  dry  ice  today, 
international shipments especially present several problems, as dry ice, under the best of circumstances, can only provide freezing for 
one to two days, in the absence of re-icing (which is quite costly). Because shipments of packages internationally can take longer than 
one to two days or be delayed due to flight cancellations, incorrect destinations, labor problems, ground logistics, customs delays and 
safety reasons, dry ice is not always a reliable and cost effective option. Clinical trial specimens are often irreplaceable because each 
one represents clinical data at a prescribed point in time, in a series of specimens on a given patient, who may be participating in a trial 
for years. Sample integrity during the shipping process is vital to retaining the maximum number of patients in each trial. Our shippers 
are ideally suited for this market, as our longer hold time ensures that specimens can be sent over long distances with minimal concern 
that they will arrive in a condition that will cause their exclusion from the trial. There are also many instances in domestic shipments 
where the CryoPort Express ® Shipper will provide higher reliability and be cost effective.  

Furthermore,  the  IATA  requires  that  all  airborne  shipments  of  laboratory  specimens  be  transmitted  in  either  IATA 
Instruction 650 or 602 certified packaging. We have developed and obtained IATA certification of the CryoPort Express  ® System, 
which is ideally suited for this market, in particular due to the elimination of the cost to return the reusable shipper.  

Gene Biotechnology. The gene biotechnology market includes basic and applied research and development in diverse areas 
such  as  stem  cells,  cloning,  gene  therapy,  DNA  tumor  vaccines,  tissue  engineering,  genomics,  and  blood  products.  Companies 
participating  in  the  foregoing  fields  rely  on  the  frozen  transport  of  specimens  in  connection  with  their  research  and  development 
efforts, for which our CryoPort Express ® Shippers are ideally suited.  

Transport of Infectious Materials and Dangerous Goods. The transport of infectious materials must be classified as such 
and  must  maintain  strict  adherence  to  regulations  that  protect  public  safety  while  maintaining  the  viability  of  the  material  being 
shipped.  Some  blood  products  are  considered  infective  and  must  be  treated  as  such.  Pharmaceutical  companies,  private  research 
laboratories and hospitals ship tissue cultures and microbiology specimens, which are also potentially infectious materials, between a 
variety  of  entities,  including  private  and  public  health  reference  laboratories.  Almost  all  specimens  in  this  infectious  materials 
category require either a refrigerated or a frozen environment. We believe our CryoPort Express ® Shipper is ideally suited to meet the 
shipping requirements of this market.  

Partly  in  response  to  the  attack  on  the  World  Trade  Center  and  the  anthrax  scare,  government  officials  and  health  care 
professionals are focusing renewed attention on the possibility of attacks involving biological and chemical weapons such as anthrax, 
smallpox and sarin gas. Efforts expended on research and development to counteract biowarfare agents requires the frozen transport of 
these agents to and from facilities conducting the research and development. Vaccine research, including methods of vaccine delivery, 
also requires frozen transport. We believe our CryoPort Express ® Shipper is ideally suited to this type of research and development.  

Pharmaceutical Distribution. The current focus for the CryoPort Express ® System also includes the area of pharmaceutical 
distribution. There are a significant number of therapeutic drugs and vaccines currently or soon to be, undergoing clinical trials. After 
the  FDA  approves  them  for  commercial  marketing,  it  will  be  necessary  for  the  manufacturers  to  have  a  reliable  and  economical 
method of distribution to the physician who will administer the product to the patient. Although there are not now a large number of 
drugs requiring  cryogenic  transport, there  are  a number  in  the  development pipeline. It is likely that the most efficient and  reliable 
method of distribution will be to ship a single dosage to the administering physician. These drugs are typically identified to individual 
patients and therefore will require a complete tracking history from the manufacturer to the patient. The most reliable method of doing 
this is to ship a unit dosage specifically for each patient. Because the drugs require maintenance at frozen or cryogenic temperatures, 
each such shipment will require a frozen or cryogenic shipping package. CryoPort anticipates being in a position to service that need.  

Fertility Clinics. We estimate that artificial insemination procedures in the United States account for at least 50,000 doses 
of semen annually. Since relatively few sperm banks provide donor semen, frozen shipping is almost always involved. As with animal 
semen,  human  semen  must  be  stored  and  shipped  at  cryogenic  temperatures  to  retain  viability,  stabilize  the  cells,  and  ensure 
reproducible results. This can only be accomplished with the use of liquid nitrogen or LN2 dry vapor shippers. CryoPort anticipates 
that this market will continue to increase as this practice gains acceptance in new areas of the world.  

In  addition  to  the  above  markets,  our  longer-term  plans  include  expanding  into  new  markets  including,  the  diagnostics, 

food, environmental, semiconductor and petroleum industries.  

Sales and Marketing  

During the fiscal year ended March 31, 2011, annual net revenues from three customers, B-D Biosciences, CDx Holdings 
and Life Technologies accounted for 19%, 38% and 11% of our total revenues, respectively. During the fiscal year ended March 31, 
2010, annual net revenue from two customers, B-D Biosciences and CDx Holdings accounted for 32% and 19% of our total revenues, 
respectively.  

   
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Our geographical sales for the year ended March 31, 2011 were as follows:  

USA and Canada  
Europe  
Asia and Rest of World  

50 % 
20 % 
30 % 

We recently entered into agreements with FedEx and DHL and we plan to further expand our sales and marketing efforts through 
the establishment of additional strategic relationships with global couriers and, subject to available financial resources, the hiring of 
additional sales and marketing personnel.  

During  the  year  ended  March  31,  2011,  we  had  one  internal  sales  person  who  manages  our  direct  sales.  In  April 2011  the 
Company  hired  a  Chief  Commercial  Officer  and  added  three  members  to  the  direct  sales  force,  of  whom  have  backgrounds  in  the 
cold-chain shipping industry.  

Industry and Competition  

Our  products  and  services  are  sold  into  a  rapidly  growing  niche  of  the  packaging  industry  focused  on  the  temperature 
sensitive  packaging  and  shipping  of  biological  materials.  Expenditures  for  “value  added”  packaging  for  frozen  transport  have  been 
increasing for the past several years and, due in part to continued globalization, are expected to continue to increase even more in the 
future as more domestic and international biotechnology firms introduce pharmaceutical products that require continuous refrigeration 
at cryogenic  temperatures. We believe  this will require a greater dependence on passively controlled temperature transport  systems 
(i.e., systems having no external power source).  

We believe that growth in the following markets has resulted in the need for increased efficiencies and greater flexibility in 

the temperature sensitive packaging market:  

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

  Pharmaceutical clinical trials, including transport of tissue culture samples;  

  Pharmaceutical commercial product distribution;  

  Transportation of diagnostic specimens;  

  Transportation of infectious materials;  

  Intra laboratory diagnostic testing;  

  Transport of temperature-sensitive specimens by courier;  

  Analysis of biological samples;  

  Environmental sampling;  

  Gene and stem cell biotechnology and vaccine production; and  

  Food engineering.  

Many of the biological products in these above markets require transport in a frozen state as well as the need for shipping 
containers which have the ability to maintain a frozen, cryogenic environment (e.g., minus 150° Celsius) for a period ranging from 
two to  ten  days (depending  on  the  distance  and  mode of  shipment).  These  products  include  semen,  embryo,  tissue,  tissue  cultures, 
cultures of viruses and bacteria, enzymes, DNA materials, vaccines and certain pharmaceutical products. In some instances, transport 
of these products requires temperatures at, or approaching, minus 196° Celsius.  

One problem faced by many companies operating in these specialized markets is the limited number of cryogenic shipping 
systems  serving  their needs,  particularly in  the  areas  of  pharmaceutical companies conducting clinical  trials. The currently  adopted 
protocol and the most common method for packaging frozen transport in these industries is the use of solid state carbon dioxide (dry 
ice). Dry ice is used extensively in shipping to maintain a frozen state for a period of one to four days. Dry ice is used in the transport 
of many biological products, such as pharmaceuticals, laboratory specimens and certain infectious materials that do not require true 
cryogenic temperatures. The common approach to shipping these items via ground freight is to pack the product in a container, such as 
an  expanded  polystyrene  (styrofoam) box  or  a  molded  polyurethane  box,  with  a  variable  quantity  of  dry  ice.  The  box  is  taped  or 
strapped shut and shipped to its destination with freight charges based on its initial shipping weight.  

With respect to shipments via specialized courier services, there is no standardized method or device currently in use for the 
purpose  of  transporting  temperature-sensitive  frozen  biological  specimens.  One  common  method  for  courier  transport  of  biological 
materials is to place frozen specimens, refrigerated specimens, and ambient specimens into a compartmentalized container, similar in 
size to a 55 quart Coleman or Igloo cooler. The freezer compartment in the container is loaded with a quantity of dry ice at minus 78° 
Celsius, while the refrigerated compartment at 8° Celsius utilizes ice substitutes.  

  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Two manufacturers of the polystyrene and polyurethane containers frequently used in the shipping and courier transport of 
dry ice frozen specimens are Insulated Shipping Containers, Inc. and Tegrant (formerly SCA Thermosafe). When these containers are 
used with dry ice, the average sublimation rate (e.g., the rate at which dry ice turns from a solid to a gaseous state) in a container with 
a 11/2 inch wall thickness is slightly less than three pounds per 24 hours. Other existing refrigerant systems employ the use of gel 
packs and ice substitutes for temperature maintenance. Gels and eutectic solutions (phase changing materials) with a wide range of 
phasing  temperatures  have  been developed  in  recent  years  to  meet the  needs  of  products  with  varying  specific  temperature control 
requirements.  

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The use of dry ice and ice substitutes, however, regardless of external packaging used, are frequently inadequate because 
they do not provide low enough storage temperatures and, in the case of dry ice, last for only a few days without re-icing. As a result, 
companies run the risk of increased costs due to lost specimens and additional shipping charges due to the need to re-ice.  

Some of the other disadvantages to using dry ice for shipping or transporting temperature sensitive products are as follows:  

• 

• 

• 

• 

• 

• 

  Availability of a dry ice source;  

  Handling and storage of the dry ice;  

  Cost of the dry ice;  

  Compliance with local, state and federal regulations relating to the storage and use of dry ice;  

  Weight of containers when packed with dry ice;  

  Securing a shipping container with a high enough R-value (which is a measure of thermal resistance) to hold the dry 

ice and product for the required time period;  

• 

  Securing  a  shipping  container  that  meets  the  requirements  of  IATA,  the  DOT,  the  CDC,  and  other  regulatory 

agencies; and  

• 

  The emission of green house gases into the environment.  

Due  to the limitations  of  dry ice, shipment of specimens at true  cryogenic  temperatures can only be accomplished using 
liquid  nitrogen  dry  vapor  shippers,  or  by  shipping  over  actual  liquid  nitrogen.  While  such  shippers  provide  solutions  to  the  issues 
encountered when shipping with dry ice, they too are experiencing some criticisms by users or potential users. For example, the cost 
for these products typically can range from $650 to $3,000 per unit, which can substantially limit their use for the transport of many 
common biologics, particularly with respect to small quantities such as, is the case with direct to the physician drug delivery. Because 
of the initial cost and limited production of these containers, they are designed to be reusable. However, the cost of returning these 
heavy containers can be significant, particularly in international markets, because most applications require only one-way shipping. 
We expect to provide a cost effective solution compared to dry ice. We believe we will provide an overall cost savings of 10% to 20% 
for international and specialty shipments compared to dry ice, while at the same time providing a higher level of support and related 
services.  

Another problem with these existing systems relates to the hold time of the unit in a normal, upright position versus the 
hold time when the unit is placed on its side or inverted. If a container is laying on its side or is inverted the liquid nitrogen is prone to 
leaking out of the container due to a combination of factors, including a shift in the equilibrium height of the liquid nitrogen in the 
absorbent material and the relocation of the point of gravity, which affects the hold time and compromises the dependability of the dry 
shipper, particularly when used in circumstances requiring lengthy shipping times. Due to the use of our proprietary technology, our 
CryoPort Express ® Shippers are not prone to leakage when on their side or inverted, thereby protecting the integrity of our shipper’s 
hold time.  

Within  our  intended  markets  for  our  CryoPort  Express  ®  Shippers,  there  is  limited  known  competition.  We  intend  to 
become competitive by reason of our improved technology in our products and through the use of our service enabled business model. 
The CryoPort Express  ®  System provides a simple and cost effective solution for the frozen or cryogenic transport of biological or 
pharmaceutical materials. This solution uses our innovative dewar and is supported by the CryoPort Express ® Portal, our web-based 
order-entry system, which manages the scheduling and shipping of the CryoPort Express ® Shippers. In addition, the traditional dry ice 
shippers  and  suppliers,  such  as  MVE/Chart  Industries,  Taylor  Wharton  and  Air  Liquide,  offer  various  models  of  dry  vapor  liquid 
nitrogen shippers that are not cost efficient for multi-use and multi-shipment purposes due to their significantly greater unit costs and 
unit  weight  (which  may  substantially  increase  the  shipping  cost).  On  the  other  hand,  they  are  more  established  and  have  larger 
organizations and have greater financial, operational, sales and marketing resources and experience in research and development than 
we do. Factors that we believe give us a competitive advantage are attributable to our shipping container which allows our shipper to 
retain  liquid  nitrogen  when  placed  in  non-upright  positions,  the  overall  “leak-proofness”  of  the  our  package  which  determines 
compliance  with  shipping  regulations  and  the  overall  weight  and  volume  of  the  package  which  determines  shipping  costs,  and  our 
business model represented by the merged integration of our shipper with CryoPort Express ® Portal and Smart Pak data logger into a 
seamless shipping, tracking and monitoring solution. Other companies that offer potentially competitive  products include Industrial 
Insulation Systems, which offers cryogenic transport units and has partnered with Marathon Products Inc., a manufacturer and global 
supplier  of  wireless  temperature  data  collecting  devices  used  for  documenting  environmentally  sensitive  products  through  the  cold 
chain and Kodiak Thermal Technologies, Inc. which offers, among other containers, a repeat use active-cool container that uses free 
piston stirling cycle technology. While not having their own shipping devices, BioStorage Technologies is potentially a competitive 
company  through  their  management  services  offered  for  cold-chain  logistics  and  long  term  biomaterial  storage.  Cryogena  offers  a 
single use disposable LN2 shipper with better performance than dry-ice, but it does not perform as well and is not as cost-effective as 
the CryoPort solution when all costs are considered. In addition, BioMatrica, Inc. is developing and offering technology that stabilizes 
biological  samples  and  research  materials  at  room  temperature.  They  presently  offer  these  technologies  primarily  to  research  and 
academic institutions; however, their technology may eventually enter the broader cold-chain market.  

  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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Research and Development  

Our research and development efforts are focused on continually improving the features of the CryoPort Express ® System 
including the web based customer service portal and the CryoPort Express ® Shippers. Further these efforts are expected to lead to the 
introduction of shippers of varying sizes based on market requirements, constructed of lower cost materials and utilizing high volume 
manufacturing methods that will make it practical to provide the cryogenic packages offered by the CryoPort Express ® System. Other 
research  and  development  effort  has  been  directed  toward  improvements  to  the  liquid  nitrogen  retention  system  to  render  it  more 
reliable in the general shipping environment and to the design of the outer packaging. Alternative phase change materials in place of 
liquid  nitrogen  may  be  used  to  increase  the  potential  markets  these  shippers  can  serve  such  as  ambient  and  2-8°C  markets.  Our 
research  and  development  expenditures  during  for  the  fiscal  years  ended  March 31,  2011  and  2010  were  $449,129  and  $284,847, 
respectively.  

Corporate Governance  

Our Board is committed to legal and ethical conduct in fulfilling its responsibilities. The Board expects all directors, as well 
as  officers  and  employees,  to  act  ethically  at  all  times  and  to  adhere  to  the  policies  comprising  the  Company’s  Code  of  Business 
Conduct and Ethics. The Board of Directors (the “Board”) of the Company adopted the corporate governance policies and charters. 
Copies  of  the  following  corporate  governance  documents  are  posted  on  our  website,  and  are  available  free  of  charge,  at 
www.cryoport.com  :  (1) Code  of  Business  Conduct  and  Ethics  (2) Charter  of  the  Nominating  and  Governance  Committee  of  the 
Board of Directors, (3) Charter of the Audit Committee of the Board of Directors, and (4) Charter of the Compensation Committee of 
the Board of Directors. If you would like a printed copy of any of these corporate governance documents, please send your request to 
CryoPort, Inc., Attention: Corporate Secretary, 20382 Barents Sea Circle, Lake Forest CA 92630.  

Human Resources  

As of March 31, 2011, we had 13 full-time employees and 9 consultants; 3 of the consultants work for us on a full-time 
basis. Each of our employees has signed a confidentiality agreement and none are covered by a collective bargaining agreement. We 
have never experienced employment-related work stoppages and consider our employee relations to be good.  

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ITEM 1A.   RISK FACTORS  

This Annual Report on Form 10-K contains forward-looking information based on our current expectations. Because our 
actual results may differ materially from any forward-looking statements made by or on behalf of CryoPort, this section includes a 
discussion  of  important  factors  that  could  affect  our  actual  future  results,  including,  but  not  limited  to,  our  potential  product  and 
service revenues, acceptance of our products and services, expenses, net income(loss) and earnings(loss) per common share.  

Risks Related to Our Business  

We have incurred significant losses to date and may continue to incur losses.  

We have incurred net losses in each fiscal year since we commenced operations. The following table represents net losses 

incurred for the years ended March 31, 2011 and 2010:  

Fiscal Year Ended March 31, 2011  

Fiscal Year Ended March 31, 2010  

Net Loss 

$  6,152,278   

$  5,651,561   

As of March 31, 2011, we had an accumulated deficit of $52,096,087. While we expect to continue to derive revenues from 
our  current  products  and  services,  in  order  to  achieve  and  sustain  profitable  operations,  we  must  successfully  commercialize  and 
launch our CryoPort Express  ® System, significantly expand our market presence and increase revenues. We may continue to incur 
losses in the future and may never generate revenues sufficient to become profitable or to sustain profitability. Continuing losses may 
impair our ability to raise the additional capital required to continue and expand our operations.  

If we are unable to obtain additional funding, we may have to reduce or discontinue our business operations.  

As  of  March 31,  2011,  we  had  cash  and  cash  equivalents  of  $9,278,443.  We  have  expended  substantial  funds  on  the 
research  and  development  of  our  products  and  IT  systems.  As  a  result,  we  have  historically  experienced  negative  cash  flows  from 
operations  and  we  expect  to  continue  to  experience  negative  cash  flows  from  operations  in  the  future.  Therefore,  our  ability  to 
continue  and  expand  our  operations  is  highly  dependent  on  the  amount  of  cash  and  cash  equivalents  on  hand  combined  with  our 
ability to raise additional capital to fund our future operations.  

We anticipate, based on currently proposed plans and assumptions relating to our ability to market and sell our products 
(but  not  including  any  additional  strategic  relationships  with  global  couriers),  that  our  cash  on  hand,  together  with  projected  cash 
flows,  will  satisfy  our  operational  and  capital  requirements  at  least  through  the  fourth  quarter  of  our  fiscal  year  2012.  There  are  a 
number of uncertainties associated with our financial projections that could reduce or delay our future projected revenues and cash-
inflows, including, but not limited to, our ability to complete the commercialization and launch of our CryoPort Express  ®  System, 
launch  our  relationship  with  FedEx,  increase  our  customer  base  and  revenues  and  enter  into  strategic  relationships  with  additional 
global  couriers.  If  our  projected  revenues  and  cash-inflows  are  reduced  or  delayed,  we  may  not  have  sufficient  capital  to  operate 
through the fourth quarter of our fiscal year 2012 unless we raise more capital. Additionally, if we are unable to realize satisfactory 
revenue in the near future, we will be required to seek additional financing to continue our operations beyond that period. We will also 
require  additional  financing  to  expand  into  other  markets  and  further  develop  and  market  our  products.  We  have  no  current 
arrangements  with  respect  to  any  additional  financing.  Consequently,  there  can  be  no  assurance  that  any  additional  financing  on 
commercially  reasonable  terms,  or  at  all,  will  be  available  when  needed.  The  inability  to  obtain  additional  capital  may  reduce  our 
ability  to  continue  to  conduct  business  operations.  Any  additional  equity  financing  may  involve  substantial  dilution  to  our  then 
existing  stockholders.  In  addition,  raising  additional  funding  may  be  complicated  by  certain  provisions  in  the  securities  purchase 
agreements and related transaction documents, as amended, entered into in connection with our prior convertible debenture financings.  

If we are not successful in establishing  strategic  relationships  with global couriers, we may  not be able to successfully increase 
revenues and cash flow which could adversely affect our operations.  

We believe that our near term success is best achieved by establishing strategic relationships with global couriers, such as 
our recent agreements with FedEx and DHL. Such relationships will enable us to provide a seamless, end-to-end shipping solution to 
customers  and  allow  us  to  leverage  the  couriers’  established  express, ground and  freight  infrastructures  and  penetrate  new  markets 
with  minimal  investment.  Further,  we  expect  that  the  global  couriers  will  utilize  their  sales  forces  to  promote  and  sell  our  frozen 
shipping services. If we are not successful in launching our relationship with FedEx or DHL or establishing additional relationships 
with  global  couriers,  our  sales  and  marketing  efforts  will  be  significantly  impacted  and  anticipated  revenue  growth  will  be 
substantially delayed which could have an adverse affect on our operations.  

Our agreements with FedEx and DHL may not result in a significant increase in our revenues or cash flow.  

On January 13, 2010, we entered into an agreement with FedEx pursuant to which we lease to FedEx such number of our 
cryogenic shippers that FedEx, from time to time, orders for its customers. FedEx has the right to and shall, on a non-exclusive basis, 
promote, market and sell transportation of our shippers and our related value-added goods and services, such as our data logger, web 

  
  
    
  
  
  
  
   
  
    
  
  
   
  
    
  
  
portal  and  planned  CryoPort  Express  ®  Smart  Pak  System.  Because  our  agreement  with  FedEx  does  not  contain  any 
requirement  that  FedEx  lease  a  minimum  number  of  shippers  from  us  during  the  term  of  the  agreement,  we  may  not  experience  a 
significant increase in our revenues or cash flows as a result of this agreement. On September 2, 2010, we entered into an agreement 
with DHL that gives DHL life sciences customers direct access to our web-based order entry and tracking portal to order our CryoPort 
Express ® Shipper and preferred DHL shipping rates. Although the agreement provides shipping discounts that may be used to support 
our customers using our CryoPort Express ® shipping solution, DHL will not be promoting, marketing or selling transportation of our 
shippers or services, which may not lead to any increase in our revenues.  

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Current  economic  conditions  and  capital  markets  are  in  a  period  of  disruption  and  instability  which  could  adversely  affect  our 
ability to access the capital markets, and thus adversely affect our business and liquidity.  

The current economic conditions and financial crisis have had, and will continue to have, a negative impact on our ability to 
access  the  capital  markets,  and  thus  have  a  negative  impact  on  our  business  and  liquidity.  The  shortage  of  liquidity  and  credit 
combined  with  substantial  losses  in  worldwide  equity  markets  could  lead  to  an  extended  worldwide  recession.  We  may  face 
significant challenges if conditions in the capital markets do not improve and we do not achieve positive cash flow from operations. 
Our ability to access the capital markets may be severely restricted at a time when we need to access such markets, which could have a 
negative  impact  on  our  business  plans,  including  the  commercialization  and  launch  of  our  CryoPort  Express  ®  System  and  other 
research and development activities. Even if we are able to raise capital, it may not be at a price or on terms that are favorable to us. 
We cannot predict the occurrence of future financial disruptions or how long the current market conditions may continue.  

The sale of substantial shares of our common stock may depress our stock price.  

As of March 31, 2011, there were 27,504,583 shares of our common stock issued and outstanding. Substantially all of these 
shares  of  common  stock  are  eligible  for  trading  in  the  public  market.  The  market  price  of  our  common  stock  may  decline  if  our 
stockholders sell  a large  number  of  shares  of  our  common  stock in  the public  market,  or  the market perceives  that  such sales  may 
occur.  

We could also issue up to 30,332,635 additional shares of our common stock including shares to be issued upon conversion 
of the outstanding balance of our convertible debentures and upon the exercise of outstanding warrants and options or reserved for 
future issuance under our stock incentive plans, as further described in the following table:  

  Number of Shares of   
   Common Stock 
  Issuable or Reserved   
For Issuance 

Common stock issuable upon conversion of the outstanding balance of our convertible debentures  
Common stock issuable upon exercise of outstanding warrants  
Common stock issuable upon exercise of outstanding options or reserved for future incentive awards under our 

stock incentive plans  

Total  

869,065   
27,822,669   

1,640,901   

30,332,635   

Of the total options and warrants outstanding as of March 31, 2011, options and warrants exercisable for an aggregate of 
23,849,159 shares of common stock would be considered dilutive to the value of our stockholders’ interest in CryoPort because we 
would receive upon exercise of such options and warrants an amount per share that is less than the market price of our common stock 
on March 31, 2011.  

We will have difficulty increasing our revenues if we experience delays, difficulties or unanticipated costs in establishing the sales, 
distribution and marketing capabilities necessary to successfully commercialize our products.  

We  are  continuing to  develop  sales, distribution and marketing  capabilities  in the  Americas, Europe  and Asia.  It will be 
expensive  and  time-consuming  for  us  to  develop  a  global  marketing  and  sales  network.  Moreover,  we  may  choose,  or  find  it 
necessary, to enter into additional strategic collaborations to sell, market and distribute our products. We may not be able to provide 
adequate  incentive  to  our  sales  force  or  to  establish  and  maintain  favorable  distribution  and  marketing  collaborations  with  other 
companies  to  promote  our  products.  In  addition,  any  third  party  with  whom  we  have  established  a  marketing  and  distribution 
relationship may not devote sufficient time to the marketing and sales of our products thereby exposing us to potential expenses in 
exiting such distribution agreements. We, and any of our third party collaborators, must also market our products in compliance with 
federal, state, local and international laws relating to the provision of incentives and inducements. Violation of these laws can result in 
substantial  penalties.  Therefore,  if  we  are  unable  to  successfully  motivate  and  expand  our  marketing  and  sales  force  and  further 
develop our sales and marketing capabilities, or if our distributors fail to promote our products, we will have difficulty increasing our 
revenues.  

Our  ability  to  grow  and  compete  in  our  industry  will  be  hampered  if  we  are  unable  to  retain  the  continued  service  of  our  key 
professionals or to identify, hire and retain additional qualified professionals.  

A  critical  factor  to  our  business  is  our  ability  to  attract  and  retain  qualified  professionals  including  key  employees  and 
consultants. We are continually at risk of losing current professionals or being unable to hire additional professionals as needed. If we 
are  unable  to  attract  new  qualified  employees,  our  ability  to  grow  will  be  adversely  affected.  If  we  are  unable  to  retain  current 
employees or strategic consultants, our financial condition and ability to maintain operations may be adversely affected.  

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We are dependent on new products and services, the lack of which would harm our competitive position.  

Our future revenue stream depends to a large degree on our ability to bring new products and services to market on a timely 
basis. We must continue to make significant investments in research and development in order to continue to develop new products 
and  services,  enhance  existing  products  and  services,  and achieve  market  acceptance  of  such  products and  services.  We  may  incur 
problems in the future in innovating and introducing new products and services. Our development stage products and services may not 
be successfully completed or, if developed, may not achieve significant customer acceptance. If we are unable to successfully define, 
develop  and  introduce  new,  competitive  products  and  services  and  enhance  existing  products  and  services,  our  future  results  of 
operations would be adversely affected. Development and manufacturing schedules for technology products and services are difficult 
to predict, and we might not achieve timely initial customer shipments of new products or launch of services. The timely availability 
of  these  products and services  and  their  acceptance  by customers  are important  to  our future  success.  A delay  in  new  or  enhanced 
product or service introductions could have a significant impact on our results of operations.  

Because  of  these  risks,  our  research  and  development  efforts  may  not  result  in  any  commercially  viable  products  or 
services.  If  significant  portions  of  these  development  efforts  are  not  successfully  completed,  or  any  new  or  enhanced  products  or 
services are not commercially successful, our business, financial condition and results of operations may be materially harmed.  

If  we  successfully  develop  products  and/or  services,  but  those  products  and/or  services  do  not  achieve  and  maintain  market 
acceptance, our business will not be profitable.  

The degree of acceptance of our CryoPort Express  ® Shipper and/or CryoPort Express  ® System, or any future product or 
services,  by  our  current  target  markets,  and  any  other  markets  to  which  we  attempt  to  sell  our  products  and  services,  and  our 
profitability and growth will depend on a number of factors including, among others:  

• 

• 

• 

• 

• 

  our shippers’ ability to perform and preserve the integrity of the materials shipped;  

  relative convenience and ease of use of our shipper and/or web portal;  

  availability of alternative products;  

  pricing and cost effectiveness; and  

  effectiveness of our or our collaborators’ sales and marketing strategy.  

If any products or services we may develop do not achieve market acceptance, then we may not generate sufficient revenue 

to achieve or maintain profitability.  

In  addition,  even  if  our  products  and  services  achieve  market  acceptance,  we  may  not  be  able  to  maintain  that  market 
acceptance over time if new products or services are introduced that are more favorably received than our products and services, are 
more cost effective, or render our products obsolete.  

We are dependent on an outside party for the continued development of our CryoPort Express ® Portal 

Our proprietary CryoPort Express  ® Portal is a software system used by our customers and business partners to automate 
the entry of orders, prepare customs documentation and facilitate status and location monitoring of shipped orders while in transit. The 
continued development of this system is contracted with an outside software development company. If this developer becomes unable 
or unwilling to continue work on scheduled projects, and an alternative developer cannot be secured, we may not be able to implement 
needed enhancements to the system. Furthermore, if we terminate our agreement with this developer and cannot reach an agreement or 
fail to fulfill an agreement for the termination, we could lose our license to use this software. Failure to proceed with enhancements or 
the  loss  of  our  license  for  the  system  would  adversely  affect  our  ability  to  generate  new  business  and  serve  existing  customers, 
resulting in a reduction in revenue.  

Our success depends, in part, on our ability to obtain patent protection for our products and business model, preserve our trade 
secrets, and operate without infringing the proprietary rights of others.  

Our policy is to seek to protect our proprietary position by, among other methods, filing United States patent applications 
related to our technology, inventions and improvements that are important to the development of our business. We have three issued 
U.S.  patents  and  one  recently  filed  provisional  patent  application,  all  relating  to  various  aspects  of  our  products  and  services.  Our 
patents or provisional patent application may be challenged, invalidated or circumvented in the future or the rights granted may not 
provide a  competitive advantage. We intend to vigorously  protect and defend our intellectual property. Costly and time-consuming 
litigation brought by us may be necessary to enforce our patents and to protect our trade secrets and know-how, or to determine the 
enforceability, scope and validity of the proprietary rights of others.  

We also rely upon trade secrets, technical know-how and continuing technological innovation to develop and maintain our 
competitive  position.  In  the  past  our  employees,  consultants,  advisors  and  suppliers  have  not  always  executed  confidentiality 
agreements  and  invention  assignment  and  work  for  hire  agreements  in  connection  with  their  employment,  consulting,  or  advisory 
relationships.  Consequently,  we  may  not  have  adequate  remedies  available  to  us  to  protect  our  intellectual  property  should  one  of 

 
  
  
  
  
  
these parties attempt to use our trade secrets or refuse to assign any rights he or she may have in any intellectual property he 
or  she  developed  for  us.  Additionally,  our  competitors  may  independently  develop  substantially  equivalent  proprietary  information 
and techniques or otherwise gain access to our proprietary technology, or we may not be able to meaningfully protect our rights in 
unpatented proprietary technology.  

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We cannot assure you that our current and potential competitors and other third parties have not filed (or in the future will 
not file) patent applications for (or have not received or in the future will not receive) patents or obtain additional proprietary rights 
that will prevent, limit or interfere with our ability to make, use or sell our products either in the United States or internationally. In the 
event we are required to license patents issued to third parties, such licenses may not be available or, if available, may not be available 
on terms acceptable to us. In addition, we cannot assure you that we would be successful in any attempt to redesign our products or 
processes to avoid infringement or that any such redesign could be accomplished in a cost-effective manner. Accordingly, an adverse 
determination in a judicial or administrative proceeding or failure to obtain necessary licenses could prevent us from manufacturing 
and selling our products or offering our services, which would harm our business.  

We  are  not  aware  of  any  third  party  that  is  infringing  any  of  our  patents  or  trademarks  nor  do  we  believe  that  we  are 

infringing on the patents or trademarks of any other person or organization.  

Our products may contain errors or defects, which could result in damage to our reputation, lost revenues, diverted development 
resources and increased service costs and litigation.  

Our products must meet stringent requirements and we must develop our products quickly to keep pace with the rapidly 
changing  market.  Products  and  services  as  sophisticated  as  ours  could  contain  undetected  errors  or  defects,  especially  when  first 
introduced  or  when  new  models  or  versions  are  released.  In  general,  our  products  may  not  be  free  from  errors  or  defects  after 
commercial  shipments  have  begun,  which  could  result  in damage to  our  reputation,  lost  revenues,  diverted  development  resources, 
increased  customer  service  and  support  costs,  and  litigation.  The  costs  incurred  in  correcting  any  product  errors  or  defects  may  be 
substantial and could adversely affect our business, results of operations and financial condition.  

If we experience manufacturing delays or interruptions in production, then we may experience customer dissatisfaction and our 
reputation could suffer.  

If we fail to produce enough shippers at our own manufacturing facility or at a third party manufacturing facility, or if we 
fail to complete our shipper recycling processes as planned, we may be unable to deliver shippers to our customers on a timely basis, 
which  could  lead  to  customer  dissatisfaction  and  could  harm  our  reputation  and  ability  to  compete.  We  currently  acquire  various 
component  parts  for  our  shippers  from  various  independent  manufacturers  in  the  United  States.  We  would  likely  experience 
significant delays or cessation in producing our shippers if a labor strike, natural disaster or other supply disruption were to occur at 
any of our main suppliers. If we are unable to procure a component from one of our manufacturers, we may be required to enter into 
arrangements with one or more alternative manufacturing companies which may cause delays in producing our shippers. In addition, 
because we depend on third party manufacturers, our profit margins may be lower, which will make it more difficult for us to achieve 
profitability.  To  date,  we  have  not  experienced  any  material  delay  that  has  adversely  impacted  our  operations.  As  our  business 
develops and the quantity of production increases, it becomes more likely that such problems could arise.  

Because  we  rely  on  a  limited  number  of  suppliers,  we  may  experience  difficulty  in  meeting  our  customers’  demands  for  our 
products in a timely manner or within budget.  

We currently purchase key components of our products from a variety of outside sources. Some of these components may 
only be available to us through a few sources, however, management has identified alternative materials and suppliers should the need 
arise. We generally do not have long-term agreements with any of our suppliers. Consequently, in the event that our suppliers delay or 
interrupt the supply of components for any reason, we could potentially experience higher product costs and longer lead times in order 
fulfillment.  

Our  CryoPort  Express  ®  Portal  may  be  subject  to  intentional  disruption  that  could  adversely  impact  our  reputation  and  future 
revenues.  

We have implemented our CryoPort Express ® Portal which is used by our customers and business partners to automate the 
entry  of  orders,  prepare  customs  documentation  and  facilitate  status  and  location  monitoring  of  shipped  orders  while  in  transit. 
Although we believe we have sufficient controls in place to prevent intentional disruptions, we could be a target of attacks specifically 
designed to impede the performance of the CryoPort Express ® Portal. Similarly, experienced computer programmers may attempt to 
penetrate our CryoPort Express ® Portal in an effort to search for and misappropriate proprietary or confidential information or cause 
interruptions  of  our  services.  Because  the  techniques  used  by  such  computer  programmers  to  access  or  sabotage  networks  change 
frequently and may not be recognized until launched against a target, we may be unable to anticipate these techniques. Our activities 
could be adversely affected and our reputation, brand and future sales harmed if these intentionally disruptive efforts are successful.  

Our products and services may expose us to liability in excess of our current insurance coverage.  

Our products and services involve significant risks of liability, which may substantially exceed the revenues we derive from 

them. We cannot predict the magnitude of these potential liabilities.  

We currently maintain general liability insurance, with coverage in the amount of $1 million per occurrence, subject to a 
$2 million annual limitation, and product liability insurance with a $1 million annual coverage limitation. Claims may be made against 
us that exceed these limits.  

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Our  liability  policy  is  an  “occurrence”  based  policy.  Thus,  our  policy  is  complete  when  we  purchased  it  and  following 
cancellation of the policy it continues to provide coverage for future claims based on conduct that took place during the policy term. 
However,  our  insurance  may  not  protect  us  against  liability  because  our  policies  typically  have  various  exceptions  to  the  claims 
covered and also require us to assume some costs of the claim even though a portion of the claim may be covered. In addition, if we 
expand  into  new  markets,  we  may  not  be  aware  of  the  need  for,  or  be  able  to  obtain  insurance  coverage  for  such  activities  or,  if 
insurance  is  obtained,  the  dollar  amount  of  any  liabilities  incurred  could  exceed  our  insurance  coverage.  A  partially  or  completely 
uninsured claim, if successful and of significant magnitude, could have a material adverse effect on our business, financial condition 
and results of operations.  

Complying with certain  regulations that apply  to  shipments  using our products  can limit our activities  and increase  our  cost  of 
operations.  

Shipments  using  our  products  and  services  are  subject  to  various  regulations  in  the  countries  in  which  we  operate.  For 
example, shipments  using our products  may be  required  to  comply with the  shipping  requirements promulgated by the  Centers for 
Disease Control (“CDC”), the Occupational Safety and Health Organization (“OSHA”), the Department of Transportation (“DOT”) as 
well  as  rules  established  by  the  International  Air  Transportation  Association  (“IATA”)  and  the  International  Civil  Aviation 
Organization  (“ICAO”).  Additionally,  our  data  logger  may  be  subject  to  regulation  and  certification  by  the  Food  and  Drug 
Administration  (“FDA”),  Federal  Communications  Commission  (“FCC”),  and  Federal  Aviation  Administration  (“FAA”).  We  will 
need  to  ensure  that  our  products  and  services  comply  with  relevant  rules  and  regulations  to  make  our  products  and  services 
marketable,  and  in  some  cases  compliance  is  difficult  to  determine.  Significant  changes  in  such  regulations  could  require  costly 
changes  to  our  products  and  services  or  prevent  use  of  our  shippers  for  an  extended  period  of  time  while  we  seek  to  comply  with 
changed  regulations.  If  we  are unable to  comply  with any  of  these  rule  or  regulations  or  fail  to obtain any required  approvals, our 
ability to market our products and services may be adversely affected. In addition, even if we are able to comply with these rules and 
regulations, compliance can result in increased costs. In either event, our financial results and condition may be adversely affected. 
We depend on our business partners and unrelated and frequently unknown third party agents in foreign countries to act on our behalf 
to complete the importation process and to make delivery of our shippers to the final user. The failure of these third parties to perform 
their duties could result in damage to the contents of the shipper resulting in customer dissatisfaction or liability to us, even if we are 
not at fault.  

If we cannot compete effectively, we will lose business.  

Our products,  services and solutions are positioned to be competitive  in  the  cold-chain shipping  market. While there  are 
technological and marketing barriers to entry, we cannot guarantee that the barriers we are capable of producing will be sufficient to 
defend  the  market  share  we  wish  to  gain  against  current  and  future  competitors.  The  principal  competitive  factors  in  this  market 
include:  

• 

• 

• 

• 

• 

• 

• 

• 

  acceptance of our business model and a per use consolidated fee structure;  

  ongoing development of enhanced technical features and benefits;  

  reductions in the manufacturing cost of competitors’ products;  

  the ability to maintain and expand distribution channels;  

  brand name;  

  the ability to deliver our products to our customers when requested;  

  the timing of introductions of new products and services; and  

  financial resources.  

Current  and  prospective  competitors  have  substantially  greater  resources,  more  customers,  longer  operating  histories, 
greater name recognition and more established relationships in the industry. As a result, these competitors may be able to develop and 
expand their networks and product offerings more quickly, devote greater resources to the marketing and sale of their products and 
adopt  more  aggressive  pricing  policies.  In  addition,  these  competitors  have  entered  and  will  likely  continue  to  enter  into  business 
relationships to provide additional products competitive to those we provide or plan to provide.  

We may not be able to compete with our competitors in the industry because many of them have greater resources than we do.  

We expect to continue to experience significant and increasing levels of competition in the future. In addition, there may be 
other companies which are currently developing competitive products and services or which may in the future develop technologies 
and products that are comparable, superior or less costly than our own. For example, some cryogenic equipment manufacturers with 
greater resources currently have solutions for storing and transporting cryogenic liquid and gasses and may develop storage solutions 
that compete with our products. Additionally, some specialty couriers with greater resources currently provide dry ice transportation 
and may develop other products in the future, both of which compete with our products. A competitor that has greater resources than 

  
  
  
  
  
  
  
  
us may be able to bring its product to market faster than we can and offer its product at a lower price than us to establish 
market share.  We  may  not be able  to successfully compete  with  a competitor  that has  greater  resources and such competition  may 
adversely affect our business.  

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Risks Relating to Our Current Financing Arrangements  

Our outstanding convertible debentures impose certain restrictions on how we conduct our business. In addition, all of our assets, 
including  our  intellectual  property,  are  pledged  to  secure  this  indebtedness.  If  we  fail  to  meet  our  obligations  to  the  debenture 
holders,  our  payment  obligations  may  be  accelerated  and  the  collateral  securing  the  indebtedness  may  be  sold  to  satisfy  these 
obligations.  

We  issued  convertible  debentures  in  October 2007  (the  “October 2007  Debentures”)  and  in  May  2008  (the  “May 2008 
Debentures,”  and  together  with  the  October 2007  Debentures,  the  “Debentures”).  The  Debentures  were  issued  to  four  institutional 
investors and have an outstanding principal balance of $2,607,196 as of March 31, 2011. In addition, in October 2007 and May 2008, 
we issued to these institutional investors warrants to purchase, as of March 31, 2011, an aggregate of 3,055,097 shares of our common 
stock (without regard to beneficial ownership limitations contained in the transaction documents and certain anti-dilution provisions). 
As  collateral  to  secure  our  repayment  obligations  to  the  holders  of  the  Debentures  we  have  granted  such  holders  a  first  priority 
security interest in generally all of our assets, including our intellectual property.  

The  Debentures  warrant  agreements  and  related  transactional  documents  (including  subsequent  amendments)  contain 
various  covenants  that  presently  restrict  our  operating  flexibility.  Pursuant  to  the  foregoing  documents,  we  may  not,  among  other 
things:  

• 

  other than the reverse stock split we effected on February 5, 2010, which the holder of our Debentures consented to, effect 

future reverse stock splits of our outstanding common stock;  

• 

  incur additional indebtedness, except for certain permitted indebtedness. Permitted indebtedness is defined to include lease 
obligations  and  purchase  money  indebtedness  of  up  to  an  aggregate  of  $200,000  and  indebtedness  that  is  expressly 
subordinated to the Debentures and matures following the maturity date of the Debentures;  

• 

  incur  additional  liens  on  any  of  our  assets  except  for  certain  permitted  liens  including  but  not  limited  liens  for  taxes, 

assessments and government charges not yet due and liens incurred in connection with permitted indebtedness;  

• 

• 

• 

• 

  pay cash dividends;  

  redeem  any  outstanding  shares  of  our  common  stock  or  any  outstanding  options  or  warrants  to  purchase  shares  of  our 
common  stock  except  in  connection  with  the  repurchase  of  stock  from  former  directors  and  officers  provided  such 
repurchases do not exceed $100,000 during the term of the Debentures;  

  enter into transactions with affiliates other than on arms-length terms; and  

  make  any  revisions  to  the  terms  of  existing  contractual  agreements  for  the  Related  Party  Notes  Payable  and  the  Line  of 

Credit (as each is referred to in our Form 10-Q for the period ended June 30, 2009).  

These provisions could have important consequences for us, including, but not limited to, (i) making it more difficult for us 
to obtain additional debt financing, or obtain new debt financing on terms favorable to us, because a new lender will have to be willing 
to be subordinate to the Debenture holders, (ii) causing us to use a portion of our available cash for debt repayment and service rather 
than other perceived needs, and/or (iii) impacting our ability to take advantage of significant, perceived business opportunities. Our 
failure  to  timely  repay  our  obligations  under  the  Debentures,  which  require  monthly  principal  payments  of  $200,000  and  quarterly 
interest  payments  that  commenced  March 1,  2011  and  which  mature  on  August 1,  2012,  or  meet  the  covenants  set  forth  in  the 
Debentures and related transaction documents could give rise to a default under the Debentures or such transaction documents. In the 
event of an uncured default, all amounts owed to the holders may be declared immediately due and payable and the Debenture holders 
will have the right to enforce their security interest in the assets securing the Debentures. In such event, the Debenture holders could 
take possession of any or all of our assets in which they hold a security interest, and dispose of those assets to the extent necessary to 
pay off our debts, which would materially harm our business.  

Certain of our existing stockholders own and have the right to acquire a substantial number of shares of common stock.  

As  of  June 10,  2011,  our  directors,  executive  officers  and  beneficial  owners  of  5%  or  more  of  our  outstanding  common 
stock  beneficially  owned  11,556,091  shares  (without  regard  to  beneficial  ownership  limitations  contained  in  certain  warrants)  of 
common stock assuming their exercise of all outstanding warrants, options and conversion of all convertible debt; or approximately 
30.80% of our outstanding common stock. Of these shares of common stock beneficially owned, 1,921,547 shares, or approximately 
6.48%  of  our  outstanding  common  stock,  are  beneficially  owned  by  Enable  Growth  Partners  LP  (and  affiliated  funds),  1,877,072 
shares,  or  approximately  6.34%  of  our  outstanding  common  stock,  are  beneficially  owned  by  BridgePointe  Master  Fund,  Ltd., 
4,285,710  shares,  or  approximately  14.02%  of  our  common  stock,  are  beneficially  owned  by  CNH  Partners,  LLC,  and  2,757,895 
shares,  or  approximately  9.14%  of  our  outstanding  common  stock,  are  beneficially  owned  by  Emergent  Financial  Group  (each 
calculated  without  regard  to  the  shares  of  common  stock  that  may  be  acquired  by  the  other  upon  the  exercise  of  its  warrants  and 
conversion  of  debt).  As  such,  the  concentration  of  beneficial  ownership  of  our  common  stock  may  have  the  effect  of  delaying  or 
preventing a change in control of CryoPort and may adversely affect the voting or other rights of other holders of our common stock.  

  
  
  
  
  
  
  
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Our stock and warrant price is and will continue to be volatile.  

The  market  price  of  our  common  stock  has  been  and,  along  with  the  warrants  is  likely  to  be,  highly  volatile  and  could 

fluctuate widely in price in response to various factors, many of which are beyond our control, including, but not limited to:  

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

  technological innovations or new products and services by us or our competitors;  

  additions or departures of key personnel;  

  sales of our common stock;  

  our ability to integrate operations, technology, products and services;  

  our ability to execute our business plan;  

  operating results below expectations;  

  loss of any strategic relationship;  

  industry developments;  

  economic and other external factors; and  

  period-to-period fluctuations in our financial results.  

You  may  consider  any  one  of  these  factors  to  be  material.  The  price  of  our  common  stock  and  warrants  may  fluctuate 
widely as a result of any of the above listed factors. In addition, the securities markets have from time to time experienced significant 
price and volume fluctuations that are unrelated to the operating performance of particular companies. These market fluctuations may 
also materially and adversely affect the market price of our common stock and warrants.  

If  equity  research  analysts  do  not  publish  research  or  reports  about  our  business  or  if  they  issue  unfavorable  commentary  or 
downgrade our common stock and warrants, the price of our common stock and warrants could decline.  

The  trading  market  for  our  common  stock  and  warrants  relies  in  part  on  the  research  and  reports  that  equity  research 
analysts  publish  about  us  and  our  business.  We  do  not  control  these  analysts.  The  price  of  our  common  stock  and  warrants  could 
decline  if  one  or  more  equity  analyst  downgrades  our  stock  or  if  analysts  issue  other  unfavorable  commentary  or  cease  publishing 
reports about us or our business.  

We have not paid dividends on our common stock in the past and do not expect to pay dividends in the foreseeable future. Any 
return on investment may be limited to the value of our common stock.  

We have never paid cash dividends on our common stock and do not anticipate paying cash dividends in the foreseeable 
future.  The  payment  of  dividends  on  our  common  stock  will  depend  on  our  earnings,  financial  condition  and  other  business  and 
economic factors affecting us at such time as the Board of Directors may consider the payment of any such dividends. In addition, we 
may  not  pay  any  dividends  without  obtaining  the  prior  consent  of  the  holders  of  our  Debentures.  If  we  do  not  pay  dividends,  our 
common stock may be less valuable because a return on your investment will only occur if the price of our common stock appreciates.  

As a result of our recent 10-to-1 reverse stock split, the liquidity of our common stock and market capitalization could be adversely 
affected.  

On  February 5,  2010,  we  effected  a  10-to-1  reverse  stock  split.  A  reverse  stock  split  is  often  viewed  negatively  by  the 
market  and,  consequently,  can  lead  to  a  decrease  in  our  overall  market  capitalization.  In  addition,  because  the  reverse  split  will 
significantly  reduce  the  number  of  shares  of  our  common  stock  that  are  outstanding,  the  liquidity  of  our  common  stock  could  be 
adversely affected and you may find it more difficult to purchase or sell shares of our common stock.  

We  may  need  additional  capital,  and  the  sale  of  additional  shares  of  common  stock  or  other  equity  securities  could  result  in 
additional dilution to our stockholders.  

We believe that our current cash and cash equivalents and anticipated cash flow from operations will be sufficient to meet 
our anticipated  cash needs  for  a  period  of at  least  12  months.  We  may,  however, require  additional  cash  resources due to  changed 
business conditions or other future developments, including any investments or acquisitions we may decide to pursue. If our resources 
are insufficient to satisfy our cash requirements, we may seek to sell additional equity or debt securities or obtain a credit facility. The 
sale  of  additional  equity  securities,  or  debt  securities  convertible  into  equity  securities,  could  result  in  additional  dilution  to  our 
stockholders.  The  incurrence  of  indebtedness  would  result  in  increased  debt  service  obligations  and  could  result  in  operating  and 
financing covenants that would restrict our operations.  

   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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Provisions in our bylaws and Nevada law might discourage, delay or prevent a change of control of our company or changes in 
our management and, as a result, may depress the trading price of our common stock.  

Provisions of our bylaws and Nevada law may discourage, delay or prevent a merger, acquisition or other change in control 
that stockholders may consider favorable, including transactions in which you might otherwise receive a premium for your shares of 
our common stock. The relevant bylaw provisions may also prevent or frustrate attempts by our stockholders to replace or remove our 
management. These provisions include advance notice requirements for stockholder proposals and nominations, and the ability of our 
Board of Directors to make, alter or repeal our bylaws.  

Absent approval of  our Board of Directors,  our bylaws  may  only be amended or repealed by  the  affirmative vote of the 

holders of at least a majority of our outstanding shares of capital stock entitled to vote.  

In addition, Section 78.438 of the Nevada Revised Statutes prohibits a publicly-held Nevada corporation from engaging in 
a business combination with an interested stockholder (generally defined as a person which together with its affiliates owns, or within 
the last three years has owned, 10% of our voting stock, for a period of three years after the date of the transaction in which the person 
became an interested stockholder) unless the business combination is approved in a prescribed manner.  

The  existence  of  the  foregoing  provisions  and  other  potential  anti-takeover  measures  could  limit  the  price  that  investors 
might  be  willing  to  pay  in  the  future  for  shares  of  our  common  stock.  They  could  also  deter  potential  acquirers  of  our  company, 
thereby reducing the likelihood that you could receive a premium for your common stock in an acquisition.  

Even though we are not incorporated in California, we may become subject to a number of provisions of the California General 
Corporation Law.  

Section 2115(b)  of  the  California  Corporations  Code  imposes  certain  requirements  of  California  corporate  law  on 
corporations organized outside California that, in general, are doing more than 50% of their business in California and have more than 
50%  of  their  outstanding  voting  securities  held  of  record  by  persons  residing  in  California.  While  we  are  not  currently  subject  to 
Section 2115(b), we may become subject to it in the future.  

The following summarizes some of the principal differences which would apply if we become subject to Section 2115(b).  

Under both Nevada and California law, cumulative voting for the election of directors is permitted. However, under Nevada 
law  cumulative  voting  must  be  expressly  authorized  in  the  Articles  of  Incorporation  and  our  Amended  and  Restated  Articles  of 
Incorporation do not authorize cumulative voting. If we become subject to Section 2115(b), we may be required to permit cumulative 
voting if any stockholder properly requests to cumulate his or her votes.  

Under Nevada law, directors may be removed by the stockholders only by the vote of two-thirds of the voting power of the 
issued and outstanding stock entitled to vote. However, California law permits the removal of directors by the vote of only a majority 
of the outstanding shares entitled to vote. If we become subject to Section 2115(b), the removal of a director may be accomplished by 
a majority vote, rather than a vote of two-thirds, of the stockholders entitled to vote.  

Under  California  law,  the  corporation  must  take  certain  steps  to  be  allowed  to  provide  for  greater  indemnification  of  its 
officers  and  directors  than  is  provided  in  the  California  Corporation  Code.  If  we  become  subject  to  Section 2115(b),  our  ability  to 
indemnify our officers and directors may be limited by California law.  

Nevada law permits distributions to stockholders as long as, after the distribution, (i) the corporation would be able to pay 
its  debts  as  they  become  due  and  (ii) the  corporation’s  total  assets  are  at  least  equal  to  its  liabilities  and  preferential  dissolution 
obligations. Under California law, distributions may be made to stockholders as long as the corporation would be able to pay its debts 
as  they  mature  and  either  (i) the  corporation’s  retained  earnings  equals  or  exceeds  the  amount  of  the  proposed  distributions,  or 
(ii) after the distributions, the corporation’s tangible assets are at least 125% of its liabilities and the corporation’s current assets are at 
least equal to its current liabilities (or, 125% of its current liabilities if the corporation’s average operating income for the two most 
recently  completed  fiscal  years  was  less  than  the  average  of  the  interest  expense  of  the  corporation  for  those  fiscal  years).  If  we 
become subject to Section 2115(b), we will have to satisfy more stringent financial requirements to be able to pay dividends to our 
stockholders. Additionally, stockholders may be liable to the corporation if we pay dividends in violation of California law.  

California  law  permits  a  corporation  to  provide  “supermajority  vote”  provisions  in  its  Articles  of  Incorporation,  which 
would require specific actions to obtain greater than a majority of the votes, but not more than 66 2 / 3 percent. Nevada law does not 
permit  supermajority  vote  provisions.  If  we  become  subject  to  Section 2115(b),  it  is  possible  that  our  stockholders  would  vote  to 
amend our Articles of Incorporation and require a supermajority vote for us to take specific actions.  

Under California law, in a disposition of substantially of all the corporation’s assets, if the acquiring party is in control of or 
under  common  control  with  the  disposing  corporation,  the  principal  terms  of  the  sale  must  be  approved  by  90 percent  of  the 
stockholders.  Although  Nevada  law  does  contain  certain  rules  governing  interested  stockholder  business  combinations,  it  does  not 
require similar stockholder approval. If we become subject to Section 2115(b), we may have to obtain the vote of a greater percentage 
of the stockholders to approve a sale of our assets to a party that is in control of, or under common control with, us.  

California  law  places  certain  additional  approval  rights  in  connection  with  a  merger  if  all  of  the  shares  of  each  class  or 
series of a corporation are not treated equally or if the surviving or parent party to a merger represents more than 50 percent of the 
voting  power  of  the  other  corporation  prior  to  the  merger.  Nevada  law  does  not  require  such  approval.  If  we  become  subject  to 
Section 2115(b), we may have to obtain a the vote of a greater percentage of the stockholders to approve a merger that treats shares of 
a class or series differently or where a surviving or parent party to the merger represents more than 50% of the voting power of the 
other corporation prior to the merger.  

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California law requires the vote of each class to approve reorganization or a conversion of a corporation into another entity. 
Nevada  law  does  not  require  a  separate  vote  for  each  class.  If  we  become  subject  to  Section 2115(b),  we  may  have  to  obtain  the 
approval of each class if we desire to reorganize or convert into another type of entity.  

California law provides greater dissenters’ rights to stockholders than Nevada law. If we become subject to Section 2115

(b), more stockholders may be entitled to dissenters’ rights, which may limit our ability to merge with another entity or reorganize.  

Our stock is deemed to be penny stock.  

Our stock is currently traded on the OTCQB, operated by the OTC Markets Group, Inc., and is subject to the “penny stock 
rules” adopted pursuant to Section 15(g) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). The penny stock 
rules apply to companies not listed on a national exchange whose common stock trades at less than $5.00 per share or which have 
tangible net worth of less than $5,000,000 ($2,000,000 if the company has been operating for three or more years). Such rules require, 
among  other  things,  that  brokers  who  trade  “penny  stock”  to  persons  other  than  “established  customers”  complete  certain 
documentation,  make  suitability  inquiries  of  investors  and  provide  investors  with  certain  information  concerning  trading  in  the 
security, including a risk disclosure document and quote information under certain circumstances. Penny stocks sold in violation of the 
applicable rules may entitle the buyer of the stock to rescind the sale and receive a full refund from the broker.  

Many brokers have decided not to trade “penny stock” because of the requirements of the penny stock rules and, as a result, 
the number of broker-dealers willing to act as market makers in such securities is limited. In the event that we remain subject to the 
“penny stock rules” for any significant period, there may develop an adverse impact on the market, if any, for our securities. Because 
our  securities  are  subject  to  the  “penny  stock  rules,”  investors  will  find  it  more  difficult  to  dispose  of  our  securities.  Further,  for 
companies whose securities are traded in the OTCQB, it is more difficult: (i) to obtain accurate quotations, (ii) to obtain coverage for 
significant  news events because major wire  services, such as the Dow Jones  News Service, generally do  not publish press  releases 
about such companies, and (iii) to obtain needed capital.  

If we fail to maintain effective internal controls over financial reporting, the price of our common stock may be adversely affected.  

Our  internal  controls  over  financial  reporting  may  have  weaknesses  and  conditions  that  could  require  correction  or 
remediation, the disclosure of which may have an adverse impact on the price of our common stock. We are required to establish and 
maintain appropriate internal controls over financial reporting. Failure to establish those controls (or any failure of those controls once 
established)  could  adversely  impact  our  public  disclosures  regarding  our  business,  financial  condition  or  results  of  operations.  In 
addition, management’s assessment of internal controls over financial reporting may identify weaknesses and conditions that need to 
be  addressed  in  our  internal  controls  over  financial  reporting  or  other  matters  that  may  raise  concerns  for  investors.  Any  actual  or 
perceived  weaknesses  and  conditions  that  need  to  be  addressed  in  our  internal  control  over  financial  reporting  and  disclosure  of 
management’s assessment of our internal controls over financial reporting may have an adverse impact on the price of our common 
stock.  

Standards for compliance with Section 404 of the Sarbanes-Oxley Act of 2002 are uncertain, and if we fail to comply in a timely 
manner, our business could be harmed and our stock price could decline.  

Rules adopted by the SEC pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 require an annual assessment of our 
internal controls over financial reporting. The standards that must be met for management to assess the internal controls over financial 
reporting as effective are evolving and complex, and require significant documentation, testing, and possible remediation to meet the 
detailed standards. We expect to continue to incur significant expenses and to devote resources to continued Section 404 compliance 
on an ongoing basis. It is difficult for us to predict how long it will take or how costly it will be to complete the assessment of the 
effectiveness of our internal controls over financial reporting and to remediate any deficiencies in our internal controls. As a result, we 
may not be able to complete the assessment and remediation process on a timely basis. In the event that our Chief Executive Officer or 
Chief Financial Officer determine that our internal controls over financial reporting are not effective as defined under Section 404, we 
cannot predict how regulators will react or how the market price of our common stock will be affected; however, we believe that there 
is a risk that investor confidence and share value may be negatively impacted.  

If we fail to remain current in our reporting requirements, our securities could be removed from the OTCQB, which would limit 
the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in the secondary market.  

Companies trading on the OTCQB must be reporting issuers under Section 12 of the Exchange Act, and must be current in 
their  reports  under  Section 13,  in  order  to  maintain  price  quotation  privileges  on  the  OTCQB  If  we  fail  to  remain  current  on  our 
reporting requirements, we could be removed from the OTCQB. As a result, the market liquidity for our securities could be severely 
adversely affected by limiting the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in 
the secondary market.  

ITEM 1B.   UNRESOLVED STAFF COMMENTS  

Not applicable.  

   
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ITEM 2.   PROPERTIES  

We  do  not  own  real  property.  We  currently  lease  two  facilities,  with  approximately  12,000  square  feet  of  corporate, 
research  and  development,  and  warehouse  facilities,  located  at  20382  Barents  Sea  Circle,  Lake  Forest,  CA  92630  and  five 
(5) executive offices located at 402 West Broadway, San Diego, CA 92101. The Company currently makes base lease payments of 
approximately  $7,000  per  month,  due  at  the  beginning  of  each  month.  On  August 24,  2009,  the  Company  entered  into  the  second 
amendment to the lease for its manufacturing and office space. The amendment extended the lease for twelve months from the end of 
the existing lease term with a right to cancel the lease with a minimum of 120 day written notice at anytime as of November 30, 2009. 
In  June 2010,  Company  entered  into  the  third  amendment  to  the  lease  for  its  manufacturing  and  office  space.  The  amendment 
extended  the  lease  for  sixty  months  commencing  July 1,  2010  with  a  right  to  cancel  the  lease  with  a  minimum  of  120 day  written 
notice  at  anytime  as  of  December 31,  2012.  On  April 15,  2010,  the  Company  entered  into  office  service  agreements  with  Regus 
Management Group, LLC  (Lessor)  for five (5) executive offices located at  402 West Broadway, San Diego, CA 92101. The office 
service agreements are for periods ranging from 3 to 7 months ending October 31, 2011. The office service agreements require base 
lease payments of approximately $9,000 per month. We believe that these facilities are adequate, suitable and of sufficient capacity to 
support  our  immediate  needs.  Additional  space  may  be  required,  however,  as  we  expand  our  research  and  development, 
manufacturing and selling and marketing activities.  

ITEM 3.   LEGAL PROCEEDINGS  

In the ordinary course of business, we are at times subject to various legal proceedings and disputes. We currently are not 
aware of any such legal proceedings or claim that we believe will have, individually or in the aggregate, a material adverse effect on 
our business, operating results or cash flows.  

ITEM 4.   [REMOVED AND RESERVED]  

Not applicable.  

PART II  

ITEM 5.   MARKET  FOR  REGISTRANT’S  COMMON  EQUITY,  RELATED  STOCKHOLDERS’  MATTERS  AND 

ISSUER PURCHASES OF EQUITY SECURITIES  

(a)   Market  Information.  The  Company’s  common  stock  is  quoted  on  the  OTCQB  under  the  symbol  “CYRX”  The 
following table shows the high and low sales price of the Company’s common stock for each quarter in the two years ended March 31, 
2011:  

Fiscal Year 2011  
Quarter Ended March 31, 2011  
Quarter Ended December 31, 2010  
Quarter Ended September 30, 2010  
Quarter Ended June 30, 2010  
Fiscal Year 2010  
Quarter Ended March 31, 2010  
Quarter Ended December 31, 2009  
Quarter Ended September 30, 2009  
Quarter Ended June 30, 2009  

Common Stock 
Sales Price 

High 

Low 

$ 
$ 
$ 
$ 

$ 
$ 
$ 
$ 

1.69     
0.95     
1.50     
2.20     

10.50     
5.40     
7.00     
9.00     

$ 
$ 
$ 
$ 

$ 
$ 
$ 
$ 

0.51   
0.43   
0.66   
1.31   

1.65   
3.80   
3.70   
4.10   

(b)  Holders. As of June 10, 2011, the number of stockholders of record of the Company’s common stock was 218.  

(c)   Dividends.  No  dividends  on  common  stock  have  been  declared  or  paid  by  the  Company.  The  Company  intends  to 
employ  all  available  funds  for  the  development  of  its  business  and,  accordingly,  does  not  intend  to  pay  any  cash  dividends  in  the 
foreseeable future.  

(d)  Securities Authorized for Issuance Under Equity Compensation. The information included under Item 12 of Part III of 

this Annual Report is hereby incorporated by reference into this Item 5 of Part II of this Annual Report.  

(e)  Recent Sale of Unregistered Securities . The following is a summary of transactions by the Company during the past 
quarter  involving  the  issuance  and  sale  of  the  Company’s  securities  that  were  not  registered  under  the  Securities  Act  of  1933,  as 
amended  (the  “Securities  Act”).  All  securities  sold  by  the  Company  were  sold  to  individuals,  trusts  or  others  who  were  accredited 
investors as defined under Regulation D under the Securities Act, as amended.  

   
  
  
    
    
    
  
  
  
  
  
  
  
  
  
    
  
  
    
    
    
  
  
  
  
  
  
    
    
    
  
  
  
  
  
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On February 4, 2011, the Company consummated the first closing of a private placement to accredited investors resulting in 
the issuance of units consisting of 6,335,318 shares of common stock and warrants to purchase 6,335,318 shares of common stock at 
an exercise price of $0.77, for gross cash proceeds of $4,434,722. On February 14, 2011, the Company completed the second closing 
of  this  same  private  placement  resulting  in  the  issuance  of  units  consisting  of  7,026,771  shares  of  common  stock  and  warrants  to 
purchase 7,026,771 shares of common stock at an exercise price of $0.77, for gross cash proceeds of $4,918,740. In both closings, 
each unit consisting of one share, together with one warrant to purchase one share, was priced at $0.70 for aggregate gross proceeds of 
$9,353,462. Aggregate net proceeds of $8,041,881 reflect placement agent fees, legal and accounting fees of $1,311,582. In addition, 
as part of the compensation to the selling agents, warrants to purchase 2,393,826 shares of common stock were issued to the agents. 
The  warrants issued  to the  investors and  selling  agents are immediately exercisable  and have a  term  of  five  years.  The fair market 
value of the warrants issued to the placement agents of $2,153,397 was based on the Black-Scholes pricing model (“Black-Scholes”) 
and was recorded to paid-in capital and offset against the proceeds of the financing with no net effect on equity. The Company was 
obligated to file a registration statement with the SEC registering the resale of the shares of common stock issued to the investors and 
the  shares  of  common  stock  underlying  the  warrants  issued  to  the  investors  within  ninety  (90) days  following  the  close  of  the 
transaction.  

On March 7, 2011 the Company entered into an Advisory Services Agreement with Marc Grossman M.D. to provide strategic 
business  advice  for which  he  was  issued  a fully-vested  warrant  to purchase 200,000  shares of the  Company’s common  stock at  an 
exercise price of $0.77 per share.  The fair value of this warrant was $302,769 of which the Company recorded $277,538 as another 
current  asset  and  recognized  $25,231  in  selling,  general  and  administrative  expense  for  the  year  ended  March 31,  2011  in  the 
accompanying consolidated financial statements.  

ITEM 6.   SELECTED FINANCIAL DATA  

The following selected financial data has been derived from audited consolidated financial statements of the Company for 
each of the five years in the period ended March 31, 2011. These selected financial summaries should be read in conjunction with the 
financial information contained for each of the two years in the period ended March 31, 2011, included in the consolidated financial 
statements  and  notes  thereto,  Management’s  Discussion  and  Analysis  of  Results  of  Operations  and  Financial  Condition,  and  other 
information provided elsewhere herein.  

Consolidated Statement of 

Operations Data:  

Revenues  
Cost of revenues  

Gross loss  

Selling, general and administrative  
Research and development  

Total operating expenses  

Loss from operations  
Other (expense) income:  

Interest income  
Interest expense  
Loss on sale of fixed assets  
Loss on extinguishment of debt  
Change in fair value of derivative 

liabilities  

Years Ended March 31,  
(in thousands, except per share data)  

2011 

2010 

2009 

2008 

2007 

$ 

476     
1,303     

$ 

118     
718     

$ 

35     
546     

$ 

84     
386     

$ 

(827 )   

4,321     
449     

4,770     

(600 )   

3,313     
284     

3,597     

(511 )   

2,387     
297     

2,684     

(302 )   

2,551     
166     

2,717     

67   
177   

(110 ) 

1,899   
88   

1,987   

(5,597 )   

(4,197 )   

(3,195 )   

(3.019 )   

(2,097 ) 

16     
(619 )   
—    
—    

8     
(7,029 )   
(9 )   
—    

32     
(2,693 )   

(10,847 )   

50     

5,577     

—    

50     
(1,593 )   

—    

—    

(228 ) 

—  

—  

(2,325 ) 
2   

Net loss before income taxes  
Income taxes  

(6,150 )   
2     

(5,650 )   
2     

(16,703 )   
2     

(4,562 )   
2     

Net loss  

Net loss per common share, basic and 

diluted  

Weighted average shares used in 

computing net loss per common 

$ 

$ 

(6,152 )   

$ 

(5,652 )   

$ 

(16,705 )   

$ 

(4,564 )   

$ 

(2,327 ) 

(0.46 )   

$ 

(1.13 )   

$ 

(4.05 )   

$ 

(1.16 )   

$ 

(0.75 ) 

  
  
    
    
    
    
    
    
    
    
    
  
  
  
    
    
    
    
  
   
  
    
    
    
    
    
    
    
    
    
  
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
   
  
    
    
    
    
    
    
    
    
    
  
share, basic and diluted  

13,302     

5,011     

4,124     

3,943     

3,094   

As of March 31,  
(in thousands)  

2011 

2010 

2009 

2008 

2007 

Consolidated Balance Sheet Data:  
Cash, cash equivalents  
Working capital (deficit)  
Total assets  
Convertible notes, net  
Other long-term obligations  
Accumulated deficit  
Total stockholders’ equity (deficit)  

$ 

$ 

9,278     
6,760     
11,031     
2,401     
1,423     
(52,096 )   
5,948     

$ 

3,630     
1,995     
4,777     
2,502     
1,478     
(45,944 )   
(915 )   

250     
(3,693 )   
1,573     
3,883     
1,601     
(30,634 )   
(4,776 )   

$ 

2,231     
981     
3,461     
902     
1,711     
(13,929 )   
—    

$ 

264   
(478 ) 
484   
96   
1,857   
(9,365 ) 
(2,288 ) 

20  

   
  
  
  
  
  
  
  
  
    
    
    
    
    
    
    
    
    
  
  
  
    
    
    
    
  
   
  
    
    
    
    
    
    
    
    
    
  
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Table of Contents  

ITEM 7.   MANAGEMENT’S  DISCUSSION  AND  ANALYSIS  OF  FINANCIAL  CONDITION  AND  RESULTS  OF 

OPERATIONS  

This Annual Report on Form 10-K contains forward-looking statements that have been made pursuant to the provisions of 
the Private Securities Litigation Reform Act of 1995 and concern matters that involve risks and uncertainties that could cause actual 
results to differ materially from those projected in the forward-looking statements. Discussions containing forward-looking statements 
may be found in the material set forth under “Business,” “Management’s Discussion and Analysis of Financial Condition and Results 
of  Operations”  and  in  other  sections  of  this  Form  10-K.  Words  such  as  “may,”  “will,”  “should,”  “could,”  “expect,”  “plan,”
“anticipate,”  “believe,”  “estimate,”  “predict,”  “potential,”  “continue”  or  similar  words  are  intended  to  identify  forward-looking 
statements, although not all forward-looking statements contain these words. Although we believe that our opinions and expectations 
reflected in the forward-looking statements are reasonable as of the date of this Annual Report on Form 10-K, we cannot guarantee 
future  results,  levels  of  activity,  performance  or  achievements,  and  our  actual  results  may  differ  substantially  from  the  views  and 
expectations set forth  in  this  Annual Report on Form 10-K. We  expressly disclaim  any intent or obligation to update  any forward-
looking statements after the date hereof to conform such statements to actual results or to changes in our opinions or expectations. 
Readers are urged to carefully review and consider the various disclosures made by us, which attempt to advise interested parties of 
the  risks,  uncertainties,  and  other  factors  that  affect  our  business,  set  forth  in  detail  in  Item 1A  of  Part I,  under  the  heading  “Risk 
Factors.”  

The  following  discussion  and  analysis  should  be  read  in  conjunction  with  our  consolidated  financial  statements  and  the 

related notes to those statements contained elsewhere in this Annual Report on Form 10-K.  

Overview  

We are a provider of an innovative cold chain frozen shipping system dedicated to providing superior, affordable cryogenic 
shipping solutions that ensure the safety, status and temperature, of high value, temperature sensitive materials. We have developed 
cost effective reusable cryogenic transport containers (referred to as “shippers”) capable of transporting biological, environmental and 
other  temperature  sensitive  materials  at  temperatures  below  minus  150°  Celsius.  These  dry  vapor  shippers  are  one  of  the  first 
significant alternatives to dry ice shipping and achieve 10-plus day holding times compared to one to two day holding times with dry 
ice.  

Our value proposition comes from providing both safe transportation and an environmentally friendly, long lasting shipper, 
and through our value added services that offer a simple, hassle-free solution for our customers. These value-added services include an 
internet-based  web  portal  that  enables  the  customer  to  initiate  scheduling,  shipping  and  tracking  of  the  progress  and  status  of  a 
shipment,  and  provides  in-transit  temperature  and  custody  transfer  monitoring  services  of  the  shipper.  The  CryoPort  service  also 
provides a fully ready charged shipper containing all freight bills, customs documents and regulatory paperwork for the entire journey 
of the shipper to our customers at their pick up location.  

Our principal focus has been the further development and commercial launch of CryoPort Express ® Portal, an innovative 
IT  solution  for  shipping  and  tracking  high-value  specimens  through  overnight  shipping  companies,  and  our  CryoPort  Express  ® 
Shipper, a dry vapor cryogenic shipper for the transport of biological and pharmaceutical materials. A dry vapor cryogenic shipper is a 
container that uses liquid nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide 
storage  temperatures  below  minus  150°  Celsius.  The  dry  vapor  shipper  is  designed  using  innovative,  proprietary,  and  patented 
technology  which  prevents  spillage  of  liquid  nitrogen  and  pressure  build  up  as  the  liquid  nitrogen  evaporates.  A  proprietary  foam 
retention system is employed to ensure that liquid nitrogen stays inside the vacuum container, even when placed upside-down or on its 
side, as is often the case when in the custody of a shipping company. Biological specimens are stored in a specimen chamber, referred 
to  as  a  “well,”  inside  the  container  and  refrigeration  is  provided  by  harmless  cold  nitrogen  gas  evolving  from  the  liquid  nitrogen 
entrapped within the foam retention system surrounding the well. Biological specimens transported using our cryogenic shipper can 
include  clinical  samples,  diagnostics,  live  cell  pharmaceutical  products  (such  as  cancer  vaccines,  semen  and  embryos,  infectious 
substances) and other items that require and/or are protected through continuous exposure to frozen or cryogenic temperatures (below 
minus 150° Celsius).  

During our early years, our limited revenue was derived from the sale of our reusable product line. Our current business 
plan focuses on per-use leasing of the shipping container and added-value services that will be used by us to provide an end-to-end 
and cost-optimized shipping solution to life  science companies moving pharmaceutical and biological samples in clinical  trials  and 
pharmaceutical distribution.  

We have incurred losses since inception and had an accumulated deficit of $52,096,087 through March 31, 2011.  

21  

   
Table of Contents  

Results of Operations  

Years Ended March 31, 2011 and 2010  

Revenues . Net revenues were $475,504 in fiscal 2011, as compared to $117,956 in fiscal 2010. The increase of $357,548 or 303% 
was the result of our current business plan focusing on per-use leasing of our shipping containers and added-value services that will be 
used  by  us  to  provide  an  end-to-end  and  cost-optimized  shipping  solution  to  life  science  companies  moving  pharmaceutical  and 
biological samples in clinical trials and pharmaceutical distribution. The less than anticipated increase in shipper revenues during the 
two  fiscal  years  was  also  the  result  of  delays  in  the  Company  securing  adequate  funding  for  the  manufacturing  and  full 
commercialization of the CryoPort Express ® System.  

Gross loss and cost of revenues. Gross loss for 2011 was 174% of revenues, or $827,484 as compared to 508%, or $599,754 for fiscal 
2010.  The  increase  in  gross  loss  in  absolute  dollars  and  the  decrease  in  gross  loss  as  a  percentage  of  revenues  for  the  year  ended 
March 31, 2011, as compared to the year ended March 31, 2010, was primarily the result of the increase in revenues from the per-use 
leasing of the shipping containers.  

The increase in cost of revenues from $717,710 for the year ended March 31, 2010 to $1,302,988 for the year ended March 31, 2011, 
was primarily the result of increased revenues. The cost of revenues exceeded revenues due to fixed manufacturing costs and plant 
underutilization.  

Selling,  general  and  administrative  expenses  .  Selling,  general  and  administrative  expenses  were  $4,320,461  in  fiscal  2011,  as 
compared to $3,312,635 in fiscal 2010. The $1,007,826 increase in expenses over prior year was due to a $900,144 or 218% increase 
in sales and marketing expenses from $412,739 for the year ended March 31, 2010, to $1,312,883 for the year ended March 31, 2011. 
The increase in sales and marketing expenses reflected our focus on market development and sales ramp up of the CryoPort Express ® 
System. An overall increase in the sales effort in 2011 increased expenses in salaries due to new hires, recruiting, travel and outside 
services due to additional sales consulting.  

Total  stock-based  compensation  costs  for  the  years  ended  March 31,  2011  and  2010  were  $396,696  and  $559,561,  respectively. 
During the year ended March 31, 2011, we granted options to employees and directors to purchase 1,296,832 shares of common stock 
at  a  weighted  average  exercise  price  of  $0.69  per  share.  The  exercise  prices  of  options  and  warrants  were  equal  to  the  fair  market 
value of our common stock at the time of grant.  

Research and development expenses . Research and development expenses were $449,129 in fiscal 2011, as compared to $284,847 in 
fiscal  2010.  The  increase  in  research  and  development  expenses  of  $164,282  was  due  primarily  to  the  costs  associated  with  the 
continued development of the internet-based web portal that enables the customer to initiate and monitor the progress of a shipment.  

Interest income . Interest income was $15,571 in fiscal year 2011, as compared to $8,164 in fiscal year 2010. Current year interest 
income included the impact of increased cash balances related to the funds received in connection with the Company’s February 2011 
private  placement,  August 2010  and  October 2010  private  placement  and  the  February 25,  2010  public  offering.  Prior  year  interest 
income included the impact of increased cash balances related to the funds received in connection with the convertible notes payable 
issued in March through September 2009.  

Interest expense . Interest expense was $618,765 in fiscal year 2011, as compared to $7,028,684 in fiscal year 2010. The decrease in 
interest expense compared to the prior year period was primarily due to the conversion of our convertible notes payable of $1,381,500 
and a portion of our convertible debentures of $2,714,430 into common stock in February 2010, and the corresponding reduction in 
debt discount amortization and interest expense. Interest expense for fiscal year 2011 included accrued interest on our Related Party 
notes payable $57,156, amortization of debt discount $522,041 and interest expense on our convertible debentures $19,233. Interest 
expense for fiscal year 2010 included amortization of debt discount of $6,417,346 and amortized financing fees of $159,516, primarily 
due to the convertible debentures issued in October 2007, May 2008 and the Private Placement Debentures.  

Change  in  fair  value  of  derivative  liabilities.  The  change  in  fair  value  of  derivative  liabilities  was  a  gain  of  $49,590  in  fiscal  year 
2011, compared to the gain of $5,576,979 in fiscal year 2010. The gain of $49,590 for the fiscal year 2011 was the result of a decrease 
in  the  fair  value  of  our  warrant  derivatives  due  primarily  to  a  decrease  in  our  stock  price,  and  a  decrease  in  the  number  of  equity 
instruments  treated  as  derivative  liabilities compared  to  the  prior fiscal  year.  The  prior year  gain  of  $5,576,979  was  the  result of  a 
decrease in the fair value of our warrant derivatives, due primarily to a decrease in our stock price.  

Income taxes . We incurred net operating losses for the years ended March 31, 2011 and March 31, 2010 and consequently did not pay 
any  federal,  state  or  foreign  income  taxes.  At  March 31,  2011,  we  had  federal  and  state  net  operating  loss  carryforwards  of 
approximately  $21,743,000  and  $21,706,000,  respectively,  which  we  have  fully  reserved  due  to  the  uncertainty  of  realization.  Our 
federal tax loss carryforwards will begin to expire in fiscal 2020, unless utilized. Our California tax loss carryforwards will begin to 
expire in fiscal 2014, unless utilized. We also have federal and California research tax credit carryforwards of approximately $17,000 
and $16,000, respectively. Our federal research tax credits will begin to expire in fiscal 2026, unless utilized. Our California research 
tax credit carryforwards do not expire and will carry forward indefinitely until utilized.  

Net loss. As a result of the factors described above, net loss for the year ended March 31, 2011 increased by $500,717 to $6,152,278 or 
($0.46) per share compared to a net loss of $5,651,561 or ($1.13) per share for the year ended March 31, 2010.  

22  

   
Table of Contents  

Liquidity and Capital Resources  

As  of  March 31,  2011,  the  Company  had  cash  and  cash  equivalents  of  $9,278,443  and  working  capital  of  $6,759,755. 
Historically,  we  have  financed  our  operations  primarily  through  sales  of  our  debt  and  equity  securities.  As  of  March 31,  2010,  the 
Company had cash and cash equivalents of $3,629,886 and working capital of $1,994,934.  

From August 2010 to October 2010, we conducted a private placement financing to institutional and accredited investors 
resulting  in  the  issuance  of  units  consisting  of  5,532,418  shares  of  common  stock  and  warrants  to  purchase  5,532,418  shares  of 
common stock at an exercise price of $0.77, for gross cash proceeds of $3,872,702 and net cash proceeds of $3,407,679. Each unit 
consisting of one share, together with one warrant to purchase one share, was priced at $0.70. Certain investors that had invested in 
our public offering that was completed on February 25, 2010 were issued additional warrants with the same terms to purchase 448,333 
shares of common stock in connection with this private placement. We paid a 7% fee to the placement agents in the aggregate amount 
of $271,090 and issued warrants to purchase an aggregate of 774,542 shares of our common stock, at an exercise price of $0.77, which 
are immediately exercisable and have a term of five years.  

On February 4, 2011, the Company consummated the first closing of a private placement to accredited investors resulting in 
the issuance of units consisting of 6,335,318 shares of common stock and warrants to purchase 6,335,318 shares of common stock at 
an exercise price of $0.77, for gross cash proceeds of $4,434,722. On February 14, 2011, the Company completed the second closing 
of  this  same  private  placement  resulting  in  the  issuance  of  units  consisting  of  7,026,771  shares  of  common  stock  and  warrants  to 
purchase 7,026,771 shares of common stock at an exercise price of $0.77, for gross cash proceeds of $4,918,740. In both closings, 
each unit consisting of one share, together with one warrant to purchase one share, was priced at $0.70 for aggregate gross proceeds of 
$9,353,462. Aggregate net proceeds which reflect placement agent fees, legal and accounting fees were $8,041,880. In addition, as 
part of the compensation to the selling agents, warrants to purchase 2,393,826 shares of common stock were issued to the agents. The 
warrants issued to the investors and selling agents are immediately exercisable and have a term of five years.  

During fiscal year 2011, we used $4,811,411 of cash for operations primarily as a result of the net loss of $6,152,278 and 
non cash expenses of $1,201,300 due primarily to discount amortization related to our convertible debt instruments and share based 
compensation.  Offsetting  the  cash  impact  of  our  net  operating  loss  (excluding  non-cash  items)  was  an  increase  in  accrued 
compensation and related expenses of $306,744 due primarily to increased selling, general and administrative expenses. During fiscal 
year 2010, we used $2,853,359 of cash for operations primarily as a result of the net loss of $5,651,561 including a non-cash gain of 
$5,576,979 due to the change in valuation of our derivative liabilities and non cash expenses of $7,790,062 due primarily to discount 
amortization  related  to  our  convertible  debt  instruments.  Offsetting  the  cash  impact  of  our  net  operating  loss  (excluding  non-cash 
items) was an increase in accrued interest payable of $335,830 primarily due to our Private Placement Debentures and an increase in 
accounts payable and accrued expenses of $209,907 due primarily to increased general and administrative expenses.  

Net  cash  used  in  investing  activities  totaled  $465,450  during  fiscal  year  2011,  primarily  attributable  the  purchase  of 
equipment $341,400 and the purchase of intangible assets of $124,050. Net cash used in investing activities totaled $138,874 during 
fiscal year 2010, primarily attributable to the decrease in restricted cash of $10,000, offset by the purchase of equipment $31,926 and 
the purchase of intangible assets of $116,948.  

Net cash provided by financing activities totaled $10,925,418 in fiscal year 2011, primarily resulting from the receipt of the 
proceeds  net  of  cash  paid  for  offering  costs  from  our  public  offering  of  common  stock  of  $11,571,286  and  gross  proceeds  from 
exercise  of  options  and  warrants  of $213,203,  which  were  partially  offset  by  payment of  deferred  financing  costs of  $275,699  and 
repayment of convertible debt of $423,372. Net cash provided by financing activities totaled $6,372,361 in fiscal year 2010, primarily 
resulting from the receipt of the proceeds net of cash paid for offering costs from our public offering of common stock of $4,046,863, 
the proceeds from the issuance of our Private Placement Debentures of $1,321,500 and gross proceeds from exercise of options and 
warrants of $1,437,100, which were partially offset by payment of deferred financing costs of $92,520 and payments on our related 
party notes payable and notes payable to officer of $120,000 and $143,950, respectively.  

The Company believes it has sufficient cash on hand and projected revenues to sustain operations for at least 12 months.  

23  

   
Table of Contents  

Contractual Obligations  

The following table summarizes our contractual obligations as of March 31, 2011:  

Less than      

Payments due by period 
1-3 
years 

Total 

1 year 

3-5 
Years 

     More than    

5 years 

Operating Lease Obligations  
Convertible Debentures (1)  
Other Long-term Debt Obligations (2)     

483,742     
$ 
   2,607,196     
   1,525,412     

156,979     
$ 
   2,176,628     
102,000     

$ 

195,237     
430,568     
192,000     

$ 

131,526     
—    
   1,231,412     

$ 

—  
—  

Total:  

$  4,616,350     

$  2,435,607     

$ 

817,805     

$  1,362,938     

$ 

0   

(1)    The Company issued convertible debentures in October 2007 (the “October 2007 Debentures”) and in May 2008 (the “May 2008 
Debentures,”  and  together  with  the  October 2007  Debentures,  the  “Debentures”).  The  Debentures  were  issued  to  four 
institutional investors and have an outstanding principal balance of $2,607,196 as of March 31, 2011. As collateral to secure our 
repayment obligations to the holders of the Debentures we have granted such holders a first priority security interest in generally 
all of our assets, including our intellectual property.  

(2)    Represents  unsecured  indebtedness  owed  to  five  related  parties,  including  four  former  members  of  the  board  of  directors,  for 
capital advances made to the Company from February 2001 through March 2005. These notes bear interest at the rate of 6% per 
annum and provide for aggregate monthly principal payments which began April 1, 2006 of $2,500, and which increased by an 
aggregate  of  $2,500  every  nine  months  to  a  maximum  of  $10,000  per  month.  As  of  March 31,  2011,  the  aggregate  principal 
payments totaled $10,000 per month. Any remaining unpaid principal and accrued interest is due at maturity March 1, 2015.  

Critical Accounting Policies and Estimates  

Management’s  discussion  and  analysis  of  financial  condition  and  results  of  operations,  as  well  as  disclosures  included 
elsewhere in this Annual Report on Form 10-K, are based upon our consolidated financial statements, which have been prepared in 
accordance with U.S. generally accepted accounting principles. Our significant accounting policies are described in the notes to the 
audited consolidated financial statements contained elsewhere in this Annual Report on Form 10-K. Included within these policies are 
our  “critical  accounting  policies.”  Critical  accounting  policies  are  those  policies  that  are  most  important  to  the  preparation  of  our 
consolidated  financial  statements  and  require  management’s  most  subjective  and  complex  judgments  due  to  the  need  to  make 
estimates about matters that are inherently uncertain. Although we believe that our estimates and assumptions are reasonable, actual 
results  may  differ  significantly  from  these  estimates.  Changes  in  estimates  and  assumptions  based  upon  actual  results  may  have  a 
material impact on our results of operations and/or financial condition.  

We  believe  that  the  critical  accounting  policies  that  most  impact  the  consolidated  financial  statements  are  as  described 

below.  

Revenue Recognition  

Per Use Revenues  

We  recognize  revenues  from  product  sales  when  there  is  persuasive  evidence  that  an  arrangement  exists,  when  title  has 
passed, the price is fixed or determinable, and we are reasonably assured of collecting the resulting receivable. The Company records 
a provision for claims based upon historical experience. Actual claims in any future period may differ from the Company’s estimates. 
During its early years, the Company’s limited revenue was derived from the sale of our reusable product line. The Company’s current 
business plan focuses on per-use leasing of the shipping container and value-added services that will be used by us to provide an end-
to-end and cost-optimized shipping solution.  

The Company provides shipping containers to their customers and charges a fee in exchange for the use of the container. 
The Company’ arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a 
period of time. The Company retains title to the containers and provides its customers the use of the container for a specified shipping 
cycle. At the culmination of the customer’s shipping cycle, the container is returned to the Company. As a result of our new business 
plan,  during  the  quarter  ended  September 30,  2009,  the  Company  reclassified  the  containers  from  inventory  to  fixed  assets  upon 
commencement of the loaned-container program.  

Inventory  

The  Company  writes  down  its  inventories  for  estimated  obsolescence  or  unmarketable  inventory  equal  to  the  difference 
between the cost of inventory and the estimated market value based upon assumptions about future demand, future pricing and market 
conditions. Inventory reserve costs are subject to estimates made by the Company based on historical experience, inventory quantities, 
age of inventory and any known expectations for product changes. If actual future demands, future pricing or market conditions are 
less favorable than those projected by management, additional inventory write-downs may be required and the differences could be 

  
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
    
    
    
  
  
    
    
    
    
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
    
    
    
    
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
     
  
material. Such differences might significantly impact cash flows from operating activities. Once established, write-downs 

are considered permanent adjustments to the cost basis of the obsolete or unmarketable inventories.  

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During  its  early  years,  the  Company’s  limited  revenue  was  derived  from  the  sale  of  our  reusable  product  line.  The 
Company’s current business plan focuses on per-use leasing of the shipping container and value-added services that will be used by us 
to  provide  an  end-to-end  and  cost-optimized  shipping  solution.  The  Company  provides  shipping  containers  to  its  customers  and 
charges a fee in exchange for the use of the container. The Company’ arrangements are similar to the accounting standard for leases 
since they convey the right to use the containers over a period of time. The Company retains title to the containers and provides its 
customers the use of the container for a specified shipping cycle. At the culmination of the customer’s shipping cycle, the container is 
returned to the Company. As a result of our current business plan, during fiscal year 2010, the Company reclassified the containers 
from inventory to fixed assets upon commencement of the loaned-container program. The Company’s current inventory consists of 
accessories that are sold and shipped to customers along with loaned containers and not returned to the Company with the containers 
at the culmination of the customer’s shipping cycle.  

Property and Equipment  

Fixed assets are stated at cost, net of accumulated depreciation and amortization. Depreciation and amortization of fixed 

assets are provided using the straight-line method over the following useful lives:  

Cryogenic Shippers  
Furniture and fixtures  
Machinery and equipment  
Leasehold improvements  

3 years 
7 years 
5-7 years 
  Lesser of lease term or estimated useful life 

Betterments,  renewals  and  extraordinary  repairs  that  extend  the  lives  of  the  assets  are  capitalized;  other  repairs  and 
maintenance charges are expensed as incurred. The cost and related accumulated depreciation and amortization applicable to assets 
retired are removed from the accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets are comprised of patents and trademarks and software development costs. The Company capitalizes costs 
of obtaining patents and trademarks which are amortized, using the straight-line method over their estimated useful life of five years. 
The Company capitalizes certain costs related to software developed for internal use. Software development costs incurred during the 
preliminary or maintenance project stages are expensed as incurred, while costs incurred during the application development stage are 
capitalized and amortized using the straight-line method over the estimated useful life of the software, which is five years. Capitalized 
costs include purchased materials and costs of services including the valuation of warrants issued to consultants.  

Long-Lived Assets  

The Company assesses the recoverability of its long-lived assets by determining whether the depreciation and amortization 
of long-lived assets over their remaining lives can be recovered through projected undiscounted cash flows. The amount of long-lived 
asset impairment is measured based on fair value and is charged to operations in the period in which long-lived asset impairment is 
determined  by  management.  Manufacturing  fixed  assets  are  subject  to  obsolescence  potential  as  result  of  changes  in  customer 
demands, manufacturing process changes and changes in materials used. The Company is not currently aware of any such changes 
that would cause impairment to the value of its manufacturing fixed assets.  

Stock-based Compensation  

We  recognize  compensation  costs  for  all  stock-based  awards  made  to  employees  and  directors.  The  fair  value  of  stock-
based awards is estimated at grant date using the Black-Scholes option pricing model and the portion that is ultimately expected to 
vest is recognized as compensation cost over the requisite service period.  

We use the Black-Scholes option-pricing model to estimate the fair value of stock-based awards. The determination of fair 
value  using  the  Black-Scholes  option-pricing  model  is  affected  by  our  stock  price  as  well  as  assumptions  regarding  a  number  of 
complex and subjective variables, including expected stock price volatility, risk-free interest rate, expected dividends and projected 
employee stock option exercise behaviors. We estimate the expected term based on the contractual term of the awards and employees’
exercise and expected post-vesting termination behavior.  

At March 31, 2011, there was $286,821 of total unrecognized compensation cost related to non-vested stock options, which 

is expected to be recognized over a remaining weighted average vesting period of 1.83 years.  

Issuance of Stock for Non-Cash Consideration  

All  transactions  in  which  goods  or  services  are  the  consideration  received  by  non-employees  for  the  issuance  of  equity 
instruments are accounted for based on the fair value of the consideration received or the fair value of the equity instrument issued, 
whichever is more reliably measurable. The measurement date used to determine the fair value of the equity instrument issued is the 
earlier of the date on which the third-party performance is complete or the date on which it is probable that performance will occur.  

   
  
    
  
  
  
  
  
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Derivative Liabilities  

Our  issued  and  outstanding  common  stock  purchase  warrants  and  embedded  conversion  features  previously  treated  as 
equity pursuant to the derivative treatment exemption were no longer afforded equity treatment, and the fair value of these common 
stock  purchase  warrants  and  embedded  conversion  features,  some  of  which  have  exercise  price  reset  features  and  some  that  were 
issued with convertible debt, from equity to liability status as if these warrants were treated as a derivative liability since their date of 
issue. The common stock purchase warrants were not issued with the intent of effectively hedging any future cash flow, fair value of 
any asset, liability or any net investment in a foreign operation. The warrants do not qualify for hedge accounting, and as such, all 
future changes in the fair value of these warrants will be recognized currently in earnings until such time as the warrants are exercised 
or expire. These common stock purchase warrants do not trade in an active securities market, and as such, we estimate the fair value of 
these warrants using the Black-Scholes option pricing model.  

Convertible Debentures  

If a conversion feature of conventional convertible debt is not accounted for as a derivative instrument and provides for a 
rate  of  conversion  that  is  below  market  value,  this  feature  is  characterized  as  a  beneficial  conversion  feature  (“BCF”).  A  BCF  is 
recorded by the Company as a debt discount. In those circumstances, the convertible debt will be recorded net of the discount related 
to the BCF. The Company amortizes the discount to interest expense over the life of the debt using the effective interest method.  

Deferred Financing Costs  

Deferred  financing  costs  represent  costs  incurred  in  connection  with  the  issuance  of  the  convertible  notes  payable  and 
private  equity  financing.  Deferred  financing  costs  are  being  amortized  over  the  term  of  the  financing  instrument  on  a  straight-line 
basis, which approximates the effective interest method, or netted against the gross proceeds from equity financings.  

Income Taxes  

We  account  for  income  taxes  under  the  provision  of  the  Financial  Accounting  Standards  Board  (“FASB”)  Accounting 
Standards Codification (“ASC”) 740, Income Taxes , or ASC 740. As of March 31, 2011 and 2010, there were no unrecognized tax 
benefits included in the accompanying balance sheets that would, if recognized, affect the effective tax rates. Based on the weight of 
available evidence, the Company’s management has determined that it is more likely than not that the net deferred tax assets will not 
be  realized.  Therefore,  the  Company  has  recorded  a  full  valuation  allowance  against  the  net  deferred  tax  assets.  The  Company’s 
income tax provision consists of state minimum taxes.  

Our  practice  is  to  recognize  interest  and/or  penalties  related  to  income  tax  matters  in  income  tax  expense.  We  had  no 
accrual for interest or penalties on our consolidated balance sheets at March 31, 2011 and 2010, respectively and have not recognized 
interest and/or penalties in the consolidated statement of operations for the year ended March 31, 2011. We are subject to taxation in 
the United States and various state jurisdictions. As of March 31, 2011, the Company is no longer subject to U.S. federal examinations 
for year before 2007 and for California franchise and income tax examinations before 2006. However, to the extent allowed by law, 
the taxing authorities may have the right to examine prior periods where net operating losses were generated and carried forward, and 
make adjustments up to the amount of the net operating loss carry forward amount. The Company is not currently under examination 
by U.S. federal or state jurisdictions.  

New Accounting Pronouncements  

In August 2010, the FASB issued Accounting Standards Update No. 2010-05, Measuring Liabilities at Fair Value, or ASU 
2010-05,  which  amends  ASC  820  to  provide  clarification  of  a  circumstance  in  which  a  quoted  price  in  an  active  market  for  an 
identical liability is not available. A reporting entity is required to measure fair value using one or more of the following methods: 1) a 
valuation  technique  that  uses  a)  the  quoted  price  of  the  identical  liability  when  traded  as  an  asset  or  b)  quoted  prices  for  similar 
liabilities (or similar liabilities when traded as assets) and/or 2) a valuation technique that is consistent with the principles of ASC 820. 
ASU  2010-05  also  clarifies  that  when  estimating  the  fair  value  of  a  liability,  a  reporting  entity  is  not  required  to  adjust  to  include 
inputs relating to the existence of transfer restrictions on that liability. The adoption did not have a material impact on our consolidated 
financial statements.  

In August 2010, the FASB issued an exposure draft on lease accounting that would require entities to recognize assets and 
liabilities arising from lease contracts on the balance sheet. The proposed exposure draft states that lessees and lessors should apply a 
“right-of-use model” in accounting for all leases. Under the proposed model, lessees would recognize an asset for the right to use the 
leased asset, and a liability for the obligation to make rental payments over the lease term. The lease term is defined as the longest 
possible term that is “more likely than not” to occur. The accounting by a lessor would reflect its retained exposure to the risks or 
benefits of the underlying leased asset. A lessor would recognize an asset representing its right to receive lease payments based on the 
expected term of the lease. Comments on this exposure draft were due by December 15, 2010 and the final standard is expected to be 
issued in the second quarter of 2011. The Company does not expect the proposed standard, as currently drafted, will have a material 
impact on its consolidated financial statements.  

   
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ITEM 7A.   QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK  

Changes  in  United  States  interest  rates  would  affect  the  interest  earned  on  our  cash  and  cash  equivalents  and  interest 

expense on our revolving credit facility.  

Based  on  our  overall  cash  and  cash  equivalents  interest  rate  exposure  at  March 31,  2011,  a  near-term  change  in  interest 

rates, based on historical movements, would not have a material adverse effect on our financial position or results of operations.  

All outstanding amounts under our Revolving Credit Facility bear interest at a variable rate equal to the lender’s prime rate 
plus a margin of 1.50% or 5.0%, whichever is higher. Interest is payable on a monthly basis and may expose us to market risk due to 
changes in interest rates. As of March 31, 2011, we had $90,388 outstanding under our Revolving Credit Facility. The interest rate at 
March 31, 2011 was 5.00%. A 10% change in interest rates on our Revolving Credit Facility would not have had a material effect on 
our net loss for the year ended March 31, 2011.  

We  have  operated  primarily  in  the  United  States.  Accordingly,  we  have  not  had  any  significant  exposure  to  foreign 

currency rate fluctuations.  

ITEM 8.   FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA  

Reference is made to the consolidated financial statements included in this Report at pages F-1 through F-31.  

ITEM 9.   CHANGES  IN  AND  DISAGREEMENTS  WITH  ACCOUNTANTS  ON  ACCOUNTING  AND  FINANCIAL 

DISCLOSURES  

None.  

ITEM 9A.   CONTROLS AND PROCEDURES  

(a) Evaluation  of  Disclosure  Controls  and  Procedures.  The  term  “disclosure  controls  and  procedures”  (defined  in 
Rule 13a-15(e) under the Securities and Exchange Act of 1934 (the “Exchange Act”) refers to the controls and other procedures of a 
company  that  are  designed  to  ensure  that  information  required  to  be  disclosed  by  a  company  in  the  reports  that  it  files  under  the 
Exchange Act is recorded, processed, summarized and reported within the required time periods. Under the supervision and with the 
participation of our management, including our chief executive officer and chief financial officer, we have conducted an evaluation of 
the  effectiveness  of  the  design  and  operation  of  our  disclosure  controls  and  procedures,  as  of  March 31,  2011.  Based  on  this 
evaluation,  our  president  and  chief  executive  officer  and  our  chief  financial  officer  concluded  that  our  disclosure  controls  and 
procedures were effective as of March 31, 2011 to ensure the timely disclosure of required information in our Securities and Exchange 
Commission filings.  

Because  of  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect  misstatements.  In 
addition, the design of any system of control is based upon certain assumptions about the likelihood of future events, and there can be 
no assurance that any design will succeed in achieving its stated goals under all future events, no matter how remote. Accordingly, 
even effective internal control over financial reporting can only provide reasonable assurance of achieving their control objectives.  

(b) Management’s Report on Internal Control Over Financial Reporting. Management’s Report on Internal Control Over 

Financial Reporting which appears on the following page is incorporated herein by this reference.  

(c) Changes  in  Internal  Control  over  Financial  Reporting.  There  have  been  no  changes  in  our  internal  control  over 
financial reporting during the fourth quarter of the fiscal year ended March 31, 2011 that have materially affected, or are reasonably 
likely to materially affect, our internal control over financial reporting.  

ITEM 9B.   OTHER INFORMATION  

None.  

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CRYOPORT, INC.  
MANAGEMENT’S REPORT ON  
INTERNAL CONTROL OVER FINANCIAL REPORTING  

The management of the Company is responsible for establishing and maintaining effective internal control over financial 
reporting and for the assessment of the effectiveness of internal control over financial reporting. The Company’s internal control over 
financial  reporting  is  a  process  designed,  as  defined  in  Rule 13a-15(f)  under  the  Securities  and  Exchange  Act  of  1934,  to  provide 
reasonable  assurance  regarding  the  reliability  of  financial  reporting  and  the  preparation  of  consolidated  financial  statements  for 
external purposes in accordance with generally accepted accounting principles.  

The Company’s internal control over financial reporting is supported by written policies and procedures that:  

• 

  pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions 

of the Company’s assets;  

• 

  provide  reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit  preparation  of  consolidated  financial 
statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the Company 
are being made only in accordance with authorizations of the Company’s management and directors; and  

• 

  provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the 

Company’s assets that could have a material effect on the consolidated financial statements.  

Because  of  its  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect  misstatements. 
Projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of 
changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.  

In  connection  with  the  preparation  of  the  Company’s  annual  consolidated  financial  statements,  management  of  the 
Company  has  undertaken  an  assessment  of  the  effectiveness  of  the  Company’s  internal  control  over  financial  reporting  based  on 
criteria  established  in  Internal  Control  —  Integrated  Framework  issued  by  the  Committee  of  Sponsoring  Organizations  of  the 
Treadway Commission (“the COSO Framework”). Management’s assessment included an evaluation of the design of the Company’s 
internal control over financial reporting and testing of the operational effectiveness of the Company’s internal control over financial 
reporting.  

Based  on  this  assessment,  management  has  concluded  that  the  Company’s  internal  control  over  financial  reporting  was 

effective as of March 31, 2011.  

This  annual  report  does  not  include  an  attestation  report  of  the  Company’s  registered  public  accounting  firm  regarding 
internal  control  over  financial  reporting.  Management’s  report  was  not  subject  to  attestation  b  the  Company’s  registered  public 
accounting firm pursuant  to temporary  rules of the Securities and Exchange  Commission  that  permit  the  Company to provide only 
management’s report in this Annual Report.  

By: 

/s/ LARRY G. STAMBAUGH 
Larry G. Stambaugh, 
  President & Chief Executive 
  Officer, and Director 

June 27, 2011  

By: 

/s/ CATHERINE M. DOLL 
Catherine M. Doll 
  Chief Financial Officer 

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PART III  

ITEM 10.   DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE  

The information required by this Item regarding our directors, executive officers and committees of our board of directors is 
incorporated by reference to the information set forth under the captions “Election of Directors” and “Executive Compensation and 
Related Matters” in our 2011 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 
2011 (the “2011 Definitive Proxy Statement”).  

Information  required  by  this  Item  regarding  Section  16(a)  reporting  compliance  is  incorporated  by  reference  to  the 
information  set  forth  under  the  caption  “Section 16(a)  Beneficial  Ownership  Reporting  Compliance”  in  our  2011  Definitive  Proxy 
Statement.  

Information  required  by  this  Item  regarding  our  code  of  ethics  is  incorporated  by  reference  to  the  information  set  forth 

under the caption “Corporate Governance” in Part I of this Annual Report on Form 10-K.  

ITEM 11.   EXECUTIVE COMPENSATION  

The information required by this Item is incorporated by reference to the information set forth under the caption “Executive 
Compensation and Related Matters” in our 2011 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year 
ended March 31, 2011.  

ITEM 12.   SECURITY  OWNERSHIP  OF  CERTAIN  BENEFICIAL  OWNERS  AND  MANAGEMENT  AND  RELATED 

STOCKHOLDER MATTERS  

The information required by this Item is incorporated by reference to the information set forth under the caption “Security 
Ownership of Directors and Executive Officers and Certain Beneficial Owners” in our 2011 Definitive Proxy Statement to be filed 
within 120 days after the end of our fiscal year ended March 31, 2011.  

ITEM 13.   CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE  

The information required by this Item is incorporated by reference to the information set forth under the captions “Certain 
Relationships and Related Transactions” and “Compensation Committee Interlocks and Insider Participation” in our 2011 Definitive 
Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 2011.  

ITEM 14.   PRINCIPAL ACCOUNTING FEES AND SERVICES  

The  information  required  by  this  Item  is  incorporated  by  reference  to  the  information  set  forth  under  the  caption 
“Independent Registered Public Accounting Firm Fees” in our 2011 Definitive Proxy Statement to be filed within 120 days after the 
end of our fiscal year ended March 31, 2011.  

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PART IV  

ITEM 15:   Exhibits and Financial Statement Schedules.  

(a)    Financial Statements  

(1)    Index to Consolidated Financial Statements  

  The financial statements required by this item are submitted in a separate section beginning on page F-1 of this report.  

Report of Independent Registered Public Accounting Firm  

Consolidated Balance Sheets at March 31, 2011 and 2010  

Consolidated Statements of Operations the years ended March 31, 2011 and 2010  

Consolidated Statements of Stockholders’ Equity (Deficit) for each years ended March 31, 2011 and 2010  

Consolidated Statements of Cash Flows for the years ended March 31, 2011 and 2010  

Notes to Consolidated Financial Statements  

2. 

  Financial Statement Schedules  

F-2   

F-3   

F-4   

F-5   

F-6   

F-8   

  All  financial  statement  schedules  are  omitted  because  they  were  not  required  or  the  required  information  is  included  in  the 

Consolidated Financial Statements and the related Notes thereto.  

3. 

  Exhibit Index  

  See Exhibit Index  

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CRYOPORT, INC.  

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS  

Report of Independent Registered Public Accounting Firm  

Consolidated Balance Sheets as of March 31, 2011 and 2010  

Consolidated Statements of Operations for the years ended March 31, 2011 and 2010  

Consolidated Statements of Stockholders’ Equity (Deficit) for the years ended March 31, 2011 and 2010  

Consolidated Statements of Cash Flows for the years ended March 31, 2011 and 2010  

Notes to Consolidated Financial Statements  

Page 

F-2   

F-3   

F-4   

F-5   

F-6   

F-8   

F-1  

   
  
  
    
  
  
  
  
   
  
    
  
  
  
   
  
    
  
  
  
   
  
    
  
  
  
   
  
    
  
  
  
   
  
    
  
  
  
   
  
    
  
  
  
   
  
    
  
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REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

To the Board of Directors of  
CryoPort, Inc.  

We have audited the accompanying consolidated balance sheets of CryoPort, Inc. (the “Company”) as of March 31, 2011 and 2010, 
and the  related consolidated  statements of  operations, stockholders’ equity (deficit) and  cash flows  for  the years  then  ended. These 
consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on 
these consolidated financial statements based on our audits.  

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those 
standards  require  that  we  plan  and  perform  the  audits  to  obtain  reasonable  assurance  about  whether  the  consolidated  financial 
statements  are  free  of  material  misstatement.  An  audit  includes  examining,  on  a  test  basis,  evidence  supporting  the  amounts  and 
disclosures in the consolidated financial statements. The Company is not required to have, nor were we engaged to perform, an audit 
of its internal control over financial reporting. Our audits included consideration of internal control over financial reporting as a basis 
for  designing  audit  procedures  that  are  appropriate  in  the  circumstances,  but  not  for  the  purpose  of  expressing  an  opinion  on  the 
effectiveness  of  the  Company’s  internal  control  over  financial  reporting.  Accordingly,  we  express  no  such  opinion.  An  audit  also 
includes  assessing  the  accounting principles  used  and  significant  estimates  made  by  management,  as  well  as  evaluating the  overall 
financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.  

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of 
CryoPort, Inc. at March 31, 2011 and 2010, and the results of its operations and its cash flows for the years then ended in conformity 
with accounting principles generally accepted in the United States of America.  

/s/ KMJ Corbin & Company LLP  

Costa Mesa, California  
June 27, 2011  

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CRYOPORT, INC.  

CONSOLIDATED BALANCE SHEETS  

Current assets:  

ASSETS  

Cash and cash equivalents  
Restricted cash  
Accounts receivable, net of allowances of $9,100 in 2011 and $1,500 in 2010  
Inventories  
Other current assets  

Total current assets  
Property and equipment, net  
Intangible assets, net  
Deposits and other assets  

Total assets  

LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT)  

Current liabilities:  

Accounts payable and accrued expenses  
Accrued compensation and related expenses  
Current portion of convertible debentures payable, net of discount of $197,226 in 2011 and $0 

in 2010  

Line of credit and accrued interest  
Current portion of related party notes payable  
Derivative liabilities  

Total current liabilities  

Related party notes payable and accrued interest, net of current portion  
Convertible debentures payable, net of current portion and discount of $8,842 in 2011 and 

$728,109 in 2010, respectively  
Total liabilities  

Commitments and contingencies  
Stockholders’ equity (deficit):  

Common stock, $0.001 par value; 250,000,000 shares authorized; 27,504,583 and 8,136,619 

shares issued and outstanding at March 31, 2011 and 2010, respectively  

Additional paid-in capital  
Accumulated deficit  

Total stockholders’ equity (deficit)  

Total liabilities and stockholders’ equity (deficit)  

March 31, 

2011 

2010 

$  9,278,443     
91,169     
55,794     
44,224     
528,045     
   9,997,675     
669,580     
354,854     
9,358     

$  3,629,886   
90,404   
81,036   
—  
104,014   
   3,905,340   
559,241   
311,965   
—  

$  11,031,467     

$  4,776,546   

$ 

506,887     
402,746     

$ 

823,653   
312,002   

   1,979,402     
90,388     
102,000     
156,497     
   3,237,920     
   1,423,412     

200,000   
90,388   
150,000   
334,363   
   1,910,406   
   1,478,256   

421,726     
   5,083,058     

   2,302,459   
   5,691,121   

27,505     
   58,016,991     
  (52,096,087 )   
   5,948,409     

8,137   
   45,021,097   
  (45,943,809 ) 
(914,575 ) 

$  11,031,467     

$  4,776,546   

See accompanying notes.  

F-3  

   
  
  
    
    
    
  
  
  
  
  
  
    
  
  
    
    
    
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
    
    
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
    
    
  
  
    
    
    
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF OPERATIONS  

Revenues  
Cost of revenues  

Gross loss  
Operating expenses:  

Selling, general and administrative  
Research and development  

Total operating expenses  

Loss from operations  
Other (expense) income:  

Interest income  
Interest expense  
Loss on sale of property and equipment  
Change in fair value of derivative liabilities  

Total other expense, net  

Loss before income taxes  

Income taxes  

Net loss  

Net loss per common share, basic and diluted  

Years Ended March 31, 
2010 
2011 
117,956   
$ 
475,504     
717,710   
   1,302,988     

$ 

(827,484 )   

(599,754 ) 

   4,320,461     
449,129     

   3,312,635   
284,847   

   4,769,590     
   (5,597,074 )   

   3,597,482   
   (4,197,236 ) 

15,571     
(618,765 )   
—    
49,590     

8,164   
   (7,028,684 ) 
(9,184 ) 
   5,576,979   

(553,604 )   

   (1,452,725 ) 

   (6,150,678 )   

   (5,649,961 ) 

1,600     

1,600   

$  (6,152,278 )   

$  (5,651,561 ) 

$ 

(0.46 )   

$ 

(1.13 ) 

Basic and diluted weighted average common shares outstanding  

   13,301,769     

   5,011,057   

See accompanying notes.  

F-4  

   
  
  
    
    
    
  
  
  
  
  
  
    
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
  
  
  
    
    
    
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
   
  
    
    
    
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
Table of Contents  

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY (DEFICIT)  

CRYOPORT, INC.  

Balance at March 31, 2009  
Cumulative effect related to adoption of new 

accounting principle  

Issuance of common stock for conversion of 

convertible notes payable including accrued 
interest  

Issuance of common stock for conversion of 

convertible debentures and accrued interest  

Reclassification of derivative liability to 

additional paid-in capital upon conversion of 
convertible notes and debentures  
Reclassification of derivative liability to 

additional paid-in capital upon effectively 
fixing conversion feature and warrant price  

Estimated fair value of warrants issued as 

commission for debt financing  
Issuance of common stock for services  
Exercise of warrants for cash, net  
Cashless exercise of warrants and stock options  
Issuance of units in public offering, net of offering 

costs of $1,257,904  

Share-based compensation related to stock options 
and warrants issued to consultants, employees 
and directors  

Fractional share adjustment for stock split  
Net loss  

Balance at March 31, 2010  
Issuance of common stock for conversion of 

convertible debentures  

Reclassification of derivative liability to 

additional paid-in capital  

Reduction of accrued offering costs in connection 

with February 2010 financing  
Issuance of common stock for services  
Exercise of warrants and options for cash  
Cashless exercise of warrants  
Issuance of units in private placement offering, 

net of offering costs of $1,776,605  

Share-based compensation related to stock options 
and warrants issued to consultants, employees 
and directors  

Net loss  

Common Stock 

Shares 

Amount 

Additional 
Paid-in 
Capital 

Accumulated       

Deficit 

Total 
Stockholders’    
Equity (Deficit)   

4,186,194      

$ 

4,186      

$ 

25,854,265      

$ 

(30,634,355 )   

$ 

(4,775,904 ) 

—     

—     

(4,217,730 )   

(9,657,893 )   

(13,875,623 ) 

519,186      

519      

1,459,682      

1,236,316      

1,237      

4,267,446      

—     

—     

1,460,201   

4,268,683   

—     

—     

—     
33,490      
479,033      
15,753      

—     

2,728,459      

—     

2,728,459   

—     

—     
33      
479      
16      

9,009,329      

63,396      
166,061      
1,359,989      
(16 )   

—     

—     
—     
—     
—     

—     

9,009,329   

63,396   
166,094   
1,360,468   
—  

3,742,097   

1,666,667      

1,667      

3,740,430      

—     
(20 )   
—     

—     
—     
—     

589,786      
—     
—     

—     
—     
(5,651,561 )   

589,786   
—  
(5,651,561 ) 

8,136,619      

$ 

8,137      

$ 

45,021,097      

$ 

(45,943,809 )   

$ 

(914,575 ) 

66,666      

—     

—     
13,636      
279,094      
114,061      

67      

—     

—     
14      
279      
114      

199,933      

128,276      

29,067      
23,985      
212,924      
(114 )   

18,894,507      

18,894      

11,430,665      

—     

—     

—     
—     
—     
—     

—     

200,000   

128,276   

29,067   
23,999   
213,203   
—  

11,449,559   

—     
—     

—     
—     

971,158      
—     

—     
(6,152,278 )   

971,158   
(6,152,278 ) 

Balance at March 31, 2011  

27,504,583      

$ 

27,505      

$ 

58,016,991      

$ 

(52,096,087 )   

$ 

5,948,409   

See accompanying notes.  

F-5  

   
  
  
     
     
     
     
     
     
     
     
     
  
  
  
     
     
     
     
     
     
     
  
  
  
     
     
  
  
     
     
     
     
   
  
     
     
     
     
     
     
     
     
     
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
     
     
     
     
     
     
     
     
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
     
     
     
     
     
     
     
     
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF CASH FLOWS  

OPERATING ACTIVITIES  

Net loss  
Adjustments to reconcile net loss to net cash used in operating activities:  

Depreciation and amortization  
Amortization of deferred financing costs  
Amortization of debt discount  
Fair value of stock issued to consultants  
Share-based compensation related to stock options and warrants issued to consultants, 

employees and directors  

Change in fair value of derivative instruments  
Loss on sale of assets  
Loss on disposal of cryogenic shippers  
Interest accrued on restricted cash  
Changes in operating assets and liabilities:  

Accounts receivable  
Inventories  
Other assets  
Accounts payable and accrued expenses  
Accrued warranty costs  
Accrued compensation and related expenses  
Accrued interest  

Net cash used in operating activities  

INVESTING ACTIVITIES  

Decrease in restricted cash  
Purchases of intangible assets  
Purchases of property and equipment  

Net cash used in investing activities  
FINANCING ACTIVITIES  

Proceeds from issuance of common stock, net of cash paid for issuance costs  
Proceeds from borrowings under convertible notes  
Repayment of convertible debentures payable  
Repayment of deferred financing costs  
Repayment of related party notes payable  
Repayments of note payable to officer  
Payment of fees associated with the exercise of warrants  
Proceeds from exercise of options and warrants  
Net cash provided by financing activities  

Net change in cash and cash equivalents  
Cash and cash equivalents, beginning of year  
Cash and cash equivalents, end of year  

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION  

Cash paid during the year for:  
Interest  
Income taxes  

F-6  

Years Ended March 31, 
2010 
2011 

$  (6,152,278 )   

$  (5,651,561 ) 

245,477     
—    
522,041     
—    

150,093   
159,516   
   6,417,346   
166,094   

477,620     
(49,590 )   
—    
6,517     
(765 )   

865,895   
   (5,576,979 ) 
9,184   
21,285   
649   

25,242     
16,004     
(155,851 )   
(109,728 )   
—    
306,744     
57,156     
   (4,811,411 )   

(78,490 ) 
81,012   
(50,219 ) 
209,907   
(18,743 ) 
105,822   
335,830   
   (2,853,359 ) 

—    
(124,050 )   
(341,400 )   
(465,450 )   

10,000   
(116,948 ) 
(31,926 ) 
(138,874 ) 

   11,571,286     
—    
(423,372 )   
(275,699 )   
(160,000 )   
—    
—    
213,203     
   10,925,418     
   5,648,557     
   3,629,886     
$  9,278,443     

   4,046,863   
   1,321,500   
—  
(92,520 ) 
(120,000 ) 
(143,950 ) 
(76,632 ) 
   1,437,100   
   6,372,361   
   3,380,128   
249,758   
$  3,629,886   

39,568     
1,600     

13,875   
1,600   

   
  
  
    
    
    
  
  
  
  
  
  
    
  
  
    
    
    
  
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
    
    
  
  
    
    
    
  
  
  
  
    
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF CASH FLOWS (CONTINUED)  

SUPPLEMENTAL DISCLOSURE OF NON-CASH INVESTING AND FINANCING 

ACTIVITIES:  

Offering costs in connection with equity financing included in accounts payable  
Settlement of accounts payable with shares of common stock  
Reduction of accrued offering costs in connection with February 2010 financing  
Conversion of debt to common stock  
Reclassification of embedded conversion feature to equity upon conversion  
Cashless exercise of warrants and stock options  
Fair value of options issued to employee in lieu of cash bonus  
Cumulative effect of accounting change to accumulated deficit for derivative liabilities  
Cumulative effect of accounting change to additional paid-in capital for derivative liabilities  
Reclassification of inventory to property and equipment  
Addition of principal due to debt modifications  
Reclassification of derivative liabilities to additional paid-in capital upon fixing conversion 

feature and warrant price  

Estimated fair value of warrants issued to related party in connection with an advisory services 

agreement  

Reclassification of property and equipment to inventories  
Cumulative effect of accounting change to debt discount for derivative liabilities  
Debt discount in connection with convertible debt financing  

Years Ended March 31, 
2010 
2011 

$ 
$ 
$ 
$ 
$ 
$ 
$ 
$ 
$ 
$ 
$ 

$ 

$ 
$ 
$ 
$ 

121,727     
23,999     
29,067     
200,000     
—    
114     
216,000     
—    
—    
—    
—    

304,766   
$ 
—  
$ 
$ 
—  
$  5,728,884   
$  2,728,459   
16   
$ 
$ 
—  
$  9,657,893   
$  4,217,730   
449,229   
$ 
646,369   
$ 

128,276     

$  9,009,329   

302,769     
60,228     
—    
—    

$ 
—  
—  
$ 
$  2,595,095   
$  1,080,201   

See accompanying notes.  

F-7  

   
  
  
    
    
    
  
  
  
  
  
  
    
  
  
    
    
    
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS  

Note 1. Organization and Summary of Significant Accounting Policies  

The Company  

CryoPort,  Inc.  (the  “Company”  or  “we”)  is  a  provider  of  an  innovative  cold  chain  frozen  shipping  system  dedicated  to 
providing superior, affordable cryogenic shipping solutions that ensure the safety, status and temperature of high value, temperature 
sensitive  materials.  The  Company  has  developed  cost-effective  reusable  cryogenic  transport  containers  (referred  to  as  “shippers”) 
capable of transporting biological, environmental and other temperature sensitive materials at temperatures below minus 150° Celsius. 
These  dry  vapor  shippers  are  one  of  the  first  significant  alternatives  to  dry  ice  shipping  and  achieve  10-plus  day  holding  times 
compared to one to two day holding times with dry ice (assuming no re-icing during transit). The Company’s value proposition comes 
from both providing  safe transportation and an  environmentally friendly, long  lasting shipper, and through  its  value-added  services 
that offer a simple hassle-free solution for its customers. These value-added services include an internet-based web portal that enables 
the customer to conveniently initiate scheduling, shipping and tracking of the progress and status of a shipment, and provides in-transit 
temperature  and  custody  transfer  monitoring  services  of  the  shipper.  Our  service  also  provides  a  fully  ready  charged  shipper 
containing all freight bills, customs documents and regulatory paperwork for the entire journey of the shipper to its customers at their 
pick up location.  

The Company’s principal focus has been the further development and commercial launch of CryoPort Express ® Portal, an 
innovative  IT  solution  for  shipping  and  tracking  high-value  specimens  through  overnight  shipping  companies,  and  it’s  CryoPort 
Express ® Shipper, a dry vapor cryogenic shipper for the transport of biological and pharmaceutical materials. A dry vapor cryogenic 
shipper is a container that uses liquid nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, 
to  provide  storage  temperatures  below  minus  150°  Celsius.  The  dry  vapor  shipper  is  designed  using  innovative,  proprietary,  and 
patented technology which prevents spillage of liquid nitrogen and pressure build up as the liquid nitrogen evaporates. A proprietary 
foam retention system is employed to ensure that liquid nitrogen stays inside the vacuum container, even when placed upside-down or 
on its side as is often the case when in the custody of a shipping company. Biological specimens are stored in a specimen chamber, 
referred  to  as  a  “well”  inside  the  containers  and  refrigeration  is  provided  by  harmless  cold  nitrogen  gas  evolving  from  the  liquid 
nitrogen  entrapped  within  the  foam  retention  system  surrounding  the  well.  Biological  specimens  transported  using  our  cryogenic 
shipper can include clinical samples, diagnostics, live cell pharmaceutical products (such as cancer vaccines, semen and embryos, and 
infectious  substances)  and  other  items  that  require  and/or  are  protected  through  continuous  exposure  to  frozen  or  cryogenic 
temperatures (less than minus 150° Celsius).  

The Company  entered into its first  strategic relationship with a  global courier on January 13, 2010 with Federal Express 
Corporation (“FedEx”) pursuant to which the Company leases to FedEx such number of its cryogenic shippers that FedEx, from time 
to time, orders for its customers. Under this agreement, FedEx has the right to and shall, on a non-exclusive basis, promote market and 
sell transportation of the Company’s shippers and its related value-added goods and services, such as its data logger, web portal and 
planned CryoPort Express ® Smart Pak System. On January 24, 2011 we announced that FedEx had launched its deep frozen shipping 
solution  using  our  CryoPort  Express  ®  Dry  Shipper.  On  September 2,  2010,  the  Company  entered  into  an  agreement  with  DHL 
Express  (USA),  Inc.  (“DHL”)  that  gives  DHL  life  science  customers  direct  access  to  the  Company’s  web-based  order  entry  and 
tracking  portal  to  order  the  CryoPort  Express  ®  Shipper  and  receive  preferred  DHL  shipping  rates.  The  agreement  covers  DHL 
shipping  discounts  that  may  be  used  to  support  the  Company’s  customers  using  the  CryoPort  Express  ®  shipping  solution.  In 
connection  with  the  agreement,  the  Company  has  integrated  its  proprietary  web  portal  to  DHL’s  tracking  and  billing  systems  to 
provide DHL life science customers with a seamless way of shipping their critical biological material worldwide. The IT integration 
with DHL was completed during the Company’s fourth quarter of fiscal year 2011.  

Basis of Presentation  

The  accompanying  consolidated  financial  statements  have  been  prepared  in  accordance  with  accounting  principles 

generally accepted in the United States of America (“U.S”) (“GAAP”).  

Reverse Stock Split  

On February 5, 2010, we effected a 10-for-1 reverse stock split of all of our issued and outstanding shares of common stock 
(the  “Reverse  Stock  Split”)  by  filing  a  Certificate  of  Amendment  to  Amended  and  Restated  Articles  of  Incorporation  with  the 
Secretary of State of Nevada. The par value and number of authorized shares of our common stock remained unchanged. The number 
of shares and per share amounts included in the consolidated financial statements and the accompanying notes have been adjusted to 
reflect the Reverse Stock Split retroactively. Unless otherwise indicated, all references to number of shares, per share amounts and 
earnings per share information contained in this report give effect to the Reverse Stock Split.  

F-8  

   
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Principles of Consolidation  

The  consolidated  financial  statements  include  the  accounts  of  CryoPort,  Inc.  and  its  wholly  owned  subsidiary,  CryoPort 

Systems, Inc. All intercompany accounts and transactions have been eliminated.  

Use of Estimates  

The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and 
assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the 
financial statements and the reported amounts of revenues and expenses during the reporting periods. Actual results could differ from 
estimated amounts. The Company’s significant estimates include allowances for doubtful accounts and sales returns, recoverability of 
long-lived  assets,  allowance  for  inventory  obsolescence,  deferred  taxes  and  their  accompanying  valuations,  valuation  of  derivative 
liabilities and valuation of common stock, warrants and stock options issued for products or services.  

Fair Value of Financial Instruments  

The  Company’s  financial  instruments  consist  of  cash  and  cash  equivalents,  restricted  cash,  accounts  receivable,  related-
party notes payable, a line of credit, convertible notes payable, accounts payable and accrued expenses. The carrying value for all such 
instruments approximates fair value at March 31, 2011 and 2010. The difference between the fair value and recorded values of the 
related party notes payable is not significant. The Company’s restricted cash is carried at amortized cost which approximates fair value 
at March 31, 2011 and 2010.  

Cash and Cash Equivalents  

The Company considers highly liquid investments with original maturities of 90 days or less to be cash equivalents.  

Concentrations of Credit Risk  

The Company maintains its cash accounts in financial institutions. Accounts at these institutions are insured by the Federal 
Deposit  Insurance  Corporation  (“FDIC”)  with  basic  deposit  coverage  limits  up  to  $250,000  per  owner.  In  addition  to  the  basic 
insurance  deposit  coverage,  the  FDIC  is  providing  temporary  unlimited  coverage  for  noninterest-bearing  transaction  accounts  from 
December 31, 2010 through December 31, 2012. At March 31, 2011 and 2010, the Company had $8,701,410 and $3,490,116 which 
exceeded  the  FDIC  insurance  limit,  respectively,  of  cash  balances,  including  restricted  cash.  The  Company  performs  ongoing 
evaluations of these institutions to limit its concentration risk exposure.  

Restricted cash  

The  Company  has  invested  cash  in  a  one  year  restricted  certificate  of  deposit  bearing  interest  at  1%  which  serves  as 
collateral for borrowings under a line of credit agreement (see Note 6). At March 31, 2011 and 2010, the balance in the certificate of 
deposit was $91,169 and $90,404, respectively.  

Customers  

The Company grants credit to customers within the U.S. and to a limited number of international customers and does not 
require collateral. Revenues from international customers are generally secured by advance payments except for a limited number of 
established  foreign  customers.  The  Company  generally  requires  advance  or  credit  card  payments  for  initial  revenues  from  new 
customers. The Company’s ability to collect receivables is affected by economic fluctuations in the geographic areas and industries 
served  by  the  Company.  Reserves  for  uncollectible  amounts  are  provided  based  on  past  experience  and  a  specific  analysis  of  the 
accounts, which management believes is sufficient. Accounts receivable at March 31, 2011 and 2010 are net of reserves for doubtful 
accounts of approximately $9,100 and $1,500, respectively. Although the Company expects to collect amounts due, actual collections 
may differ from the estimated amounts.  

The Company has foreign revenues primarily in Europe, Canada, India and Australia. During fiscal years 2011 and 2010, 
the Company had foreign revenues of approximately $232,000 and $67,000, respectively, which constituted approximately 51% and 
56% of total revenues, respectively.  

The  majority  of  the  Company’s  customers  are  in  the  biotechnology,  pharmaceutical  and  life  science  industries. 
Consequently,  there  is  a  concentration  of  receivables  within  these  industries,  which  is  subject  to  normal  credit  risk.  At  March 31, 
2011, annual revenues from three customers accounted for 68% of our total revenues. At March 31, 2010, annual net revenues from 
two  customers  accounted  for  51%  of  our  total  revenues.  The  Company  maintains  reserves  for  bad  debt  and  such  losses,  in  the 
aggregate, historically have not exceeded our estimates.  

Inventories  

The Company’s inventories consist of $37,739 in raw material and $6,485 in finished goods, which represents accessories 
that are sold and shipped to customers along with pay-per-use containers and not returned to the Company with the containers at the 
culmination of the customer’s shipping cycle.  

Inventories  are  stated  at  the  lower  of  cost  or  current  estimated  market  value.  Cost  is  determined  using  the  standard  cost 
method  which  approximates  the  first-in,  first-to-expire  method.  Inventories  are  reviewed  periodically  for  slow-moving  or  obsolete 
status.  The  Company  write  downs  the  carrying  value  of  its  inventories  to  reflect  situations  in  which  the  cost  of  inventories  is  not 
expected to be recovered. Once established, write-downs of inventories are considered permanent adjustments to the cost basis of the 
obsolete  or  excess  inventories.  Raw  materials  and  finished  goods  include  material  costs  less  reserves  for  obsolete  or  excess 
inventories. The Company evaluates the current level of inventories considering historical trends and other factors, and based on the 
evaluation,  records  adjustments  to  reflect  inventories  at  its  net  realizable  value. These  adjustments  are  estimates,  which  could vary 
significantly  from  actual  results  if  future  economic  conditions,  customer  demand,  competition  or  other  relevant  factors  differ  from 
expectations. These estimates require us to make assessments about future demand for the Company’s products in order to categorize 
the  status  of  such  inventories  items  as  slow-moving,  obsolete  or  in  excess-of-need.  These  estimates  are  subject  to  the  ongoing 
accuracy of the Company’s forecasts of market conditions, industry trends, competition and other factors.  

In fiscal year 2010, the Company changed its operations and now provides shipping containers to its customers and charges 
a fee in exchange for the use of the container. The Company’s arrangements are similar to the accounting standard for leases since 
they  convey  the  right  to  use  the  containers  over  a  period  of  time.  The  Company  retains  title  to  the  containers  and  provides  its 
customers the use of the container for a specified shipping cycle. At the culmination of the customer’s shipping cycle, the container is 
returned to the Company. As a result, during the fiscal year 2010, the Company reclassified the containers from inventory to fixed 
assets upon commencement of the per-use container program.  

F-9  

   
Table of Contents  

Property and Equipment  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Property and equipment are recorded at cost. Cryogenic shippers, which comprise of 84% of the Company’s net property 
and  equipment  balance  at  March 31,  2011,  are  depreciated  using  the  straight-line  method  over  their  estimated  useful  lives  of  three 
years.  Equipment  and  furniture  are  depreciated  using  the  straight-line  method  over  their  estimated  useful  lives  (generally  three  to 
seven years) and leasehold improvements are amortized using the straight-line method over the estimated useful life of the asset or the 
lease term, whichever is shorter. Equipment acquired under capital leases is amortized over the estimated useful life of the assets or 
term of the lease, whichever is shorter and included in depreciation expense.  

Betterments,  renewals  and  extraordinary  repairs  that  extend  the  lives  of  the  assets  are  capitalized;  other  repairs  and 
maintenance charges are expensed as incurred. The cost and related accumulated depreciation and amortization applicable to assets 
retired are removed from the accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets are comprised of patents and trademarks and software development costs. The Company capitalizes costs 
of obtaining patents and trademarks which are amortized, using the straight-line method over their estimated useful life of five years. 
The Company capitalizes certain costs related to software developed for internal use. Software development costs incurred during the 
preliminary or maintenance project stages are expensed as incurred, while costs incurred during the application development stage are 
capitalized and amortized using the straight-line method over the estimated useful life of the software, which is five years. Capitalized 
costs include purchased materials and costs of services including the valuation of warrants issued to consultants.  

Long-lived Assets  

If indicators of impairment exist, we assess the recoverability of the affected long-lived assets by determining whether the 
carrying  value  of  such  assets  can  be  recovered  through  undiscounted  future  operating  cash  flows.  If  impairment  is  indicated,  we 
measure  the  amount of such impairment  by  comparing the  fair  value  to  the carrying value.  We  believe  the future cash flows  to  be 
received from the long-lived assets will exceed the assets’ carrying value, and accordingly, we have not recognized any impairment 
losses through March 31, 2011.  

Deferred Financing Costs  

Deferred  financing  costs  represent  costs  incurred  in  connection  with  the  issuance  of  the  convertible  notes  payable  and 
private equity financing. Deferred financing costs related to the issuance of debt are being amortized over the term of the financing 
instrument  using  the  effective  interest  method  while  deferred  financing  costs  from  equity  financings  are  netted  against  the  gross 
proceeds received from the equity financings.  

During the year  ended March 31, 2011,  the  Company incurred $465,023  of offering costs in connection with the  private 
placement that closed in August 2010 and October 2010 and $1,311,582 of offering costs from the private placement that closed in 
February 2011; both of which were charged to paid-in capital and netted against the proceeds received in the private placements. As of 
March  31,  2011,  offering  costs  of $121,727 related  to  the  February 2011  private  placement  were included  in accounts payable and 
accrued expenses in the accompanying consolidated balance sheet.  

During the year ended March 31, 2010, the Company completed a public offering of units consisting of 1,666,667 shares of 
common stock and 1,666,667 warrants to purchase one share of common stock at an exercise price of $3.30, for gross proceeds of 
$5,000,001 and net proceeds of approximately $3,742,097 (the “February 2010 Public Offering”). Each unit consisting of one share, 
together with one warrant to purchase one share, was priced at $3.00. In connection with this public offering the Company incurred 
financing costs of $1,257,904, which consisted primarily of placement agent fees, accounting, legal and filing fees and were netted 
against the proceeds of the offering upon completion.  

During the year ended March 31, 2010, and in connection with the issuance of convertible notes payable (see Note 8), the 
Company  paid  financing  costs,  which  consisted  primarily  of  placement  agent  fees,  accounting,  legal  and  filing  fees,  and  were 
amortized over the life of the debt. Amortization of deferred financing costs using the effective interest method was $0 and $159,516 
for the years ended March 31, 2011 and 2010, respectively, and were included in interest expense in the accompanying consolidated 
statements  of  operations.  Additionally,  during  the  year  ended  March  31,  2011,  the  Company  made  payments  of  $275,699  in 
connection with the deferred financing fees related to the February 2010 Public Offering, which were included in accounts payable 
and accrued expenses in the accompanying consolidated balance sheet at March 31, 2010.  

Accrued Warranty Costs  

Estimated costs of the Company’s standard warranty were included with products at no additional cost to the customer for a 
period up to one year and were recorded as accrued warranty costs at the time of product sale. Costs related to servicing the standard 

warranty were charged to the accrual as incurred.  

Convertible Debentures  

If a conversion feature of conventional convertible debt is not accounted for as a derivative instrument and provides for a 
rate  of  conversion  that  is  below  market  value,  this  feature  is  characterized  as  a  beneficial  conversion  feature  (“BCF”).  A  BCF  is 
recorded by the Company as a debt discount. The convertible debt is recorded net of the discount related to the BCF. The Company 
amortizes the discount to interest expense over the life of the debt using the effective interest rate method.  

Derivative Liabilities  

Effective April 1, 2009, certain of the Company’s issued and outstanding common stock purchase warrants and embedded 
conversion  features  previously  treated  as  equity  pursuant  to  the  derivative  treatment  exemption  were  no  longer  afforded  equity 
treatment,  and  the  fair  value  of  these  common  stock  purchase  warrants  and  embedded  conversion  features,  some  of  which  have 
exercise price reset features and some that were issued with convertible debt, were reclassified from equity to liability status as if these 
warrants were treated as a derivative liability since their date of issue. The common stock purchase warrants were not issued with the 
intent of effectively hedging any future cash flow, fair value of any asset, liability or any net investment in a foreign operation. The 
warrants  do  not  qualify  for  hedge  accounting,  and  as  such,  all  future  changes  in  the  fair  value  of  these  warrants  are  recognized 
currently in earnings until such time as the warrants are exercised, expire or the related rights have been waived. These common stock 
purchase  warrants do  not  trade  in  an active  securities  market,  and  as  such, the  Company  estimates  the  fair  value  of these  warrants 
using the Black-Scholes option pricing model (“Black-Scholes”) (see Note 9).  

F-10  

   
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Commitments and Contingencies  

The  Company  is  subject  to  routine  claims  and  litigation  incidental  to  our  business.  In  the  opinion  of  management,  the 

resolution of such claims is not expected to have a material adverse effect on our operating results or financial position.  

Income Taxes  

The  Company  accounts  for  income  taxes  under  the  provision  of  the  Financial  Accounting  Standards  Board  (“FASB”) 
Accounting  Standards  Codification  (“ASC”)  740,  Income  Taxes  ,  or  ASC  740.  As  of  March 31,  2011  and  2010,  there  were  no 
unrecognized tax benefits included in the accompanying consolidated balance sheets that would, if recognized, affect the effective tax 
rates. Based on the weight of available evidence, the Company’s management has determined that it is more likely than not that the 
net deferred tax assets will not be realized. Therefore, the Company has recorded a full valuation allowance against the net deferred 
tax assets. The Company’s income tax provision consists of state minimum taxes.  

The Company’s policy is to recognize interest and/or penalties related to income tax matters in income tax expense. The 
Company had no accrual for interest or penalties on its consolidated balance sheets at March 31, 2011 and 2010, respectively and has 
not recognized interest and/or penalties in the consolidated statement of operations for the years ended March 31, 2011 and 2010. The 
Company is subject to taxation in the U.S. and various state jurisdictions. As of March 31, 2011, the Company is no longer subject to 
U.S.  federal  examinations  for  years  before  2007  per  Note  14  and  for  California  franchise  and  income  tax  examinations  for  years 
before 2006 per Note 14. However, to the extent allowed by law, the taxing authorities may have the right to examine prior periods 
where net operating losses were generated and carried forward, and make adjustments up to the amount of the net operating loss carry 
forward amount. The Company is not currently under examination by U.S. federal or state jurisdictions.  

Supply Concentration Risks  

The component parts for our products are primarily manufactured at third party manufacturing facilities. The Company also 
has a warehouse at our corporate offices in Lake Forest, California, where the Company is capable of manufacturing certain parts and 
fully  assembles its  products.  Most  of  the  components  that  the Company  uses  in  the  manufacture  of  its  products are  available from 
more  than  one  qualified  supplier.  For  some  components,  however,  there  are  relatively  few  alternate  sources  of  supply  and  the 
establishment  of  additional  or  replacement  suppliers  may  not  be  accomplished  immediately,  however,  the  Company  has  identified 
alternate qualified suppliers which the Company believes could replace existing suppliers. Should this occur, the Company believes 
that  with  its  current  level  of  shippers  and  production  rate  the  Company  has  enough  to  cover  a  four  to  six  week  gap  in  maximum 
disruption of production.  

There are no specific agreements with any manufacturer nor are there any long term commitments to any manufacturer. The 
Company believes that any of the manufactures currently used by it could be replaced within a short period of time as none have a 
proprietary component or a substantial capital investment specific to its products.  

Revenue Recognition  

The Company provides shipping containers to their customers and charges a fee in exchange for the use of the container. 
The Company’s arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a 
period of time. The Company retains title to the containers and provides its customers the use of the container for a specified shipping 
cycle. At the culmination of the customer’s shipping cycle, the container is returned to the Company.  

The Company recognizes revenue for the use of the shipper at the time of the delivery of the shipper to the end user of the 
enclosed materials, and at the time that collectability is reasonably certain. Revenue is based on gross net of discounts and allowances. 

Accounting for Shipping and Handling Revenue, Fees and Costs  

The  Company  classifies  amounts  billed  for  shipping  and  handling  as  revenue.  Shipping  and  handling  fees  and  costs  are 

included in cost of sales in the accompanying consolidated statements of operations.  

Research and Development Expenses  

Expenditures  relating  to  research  and  development  are  expensed  in  the  period  incurred.  Research  and  development 
expenses to date have consisted primarily of costs associated with the continually improving the features of the CryoPort Express  ® 
System including the web based customer service portal and the CryoPort Express  ® Shippers. Further, these efforts are expected to 
lead to the introduction of shippers of varying sizes based on market requirements, constructed of lower cost materials and utilizing 
high volume manufacturing methods that will make it practical to provide the cryogenic packages offered by the CryoPort Express ® 
System.  Other  research  and  development  effort  has  been  directed  toward  improvements  to  the  liquid  nitrogen  retention  system  to 
render  it  more  reliable  in  the  general  shipping  environment  and  to  the  design  of  the  outer  packaging.  Alternative  phase  change 
materials in place of liquid nitrogen may be used to increase the potential markets these shippers can serve such as ambient and 2-8°C 

markets.  

Stock-based Compensation  

The  Company  recognizes  compensation  expense  for  all  stock-based  awards  made  to  employees  and  directors.  The  fair 
value  of  stock-based  awards  is  estimated  at  grant  date  using  Black-Scholes  and  the  portion  that  is  ultimately  expected  to  vest  is 
recognized as compensation cost over the requisite service period.  

Since stock-based compensation is recognized only for those awards that are ultimately expected to vest, the Company has 
applied  an  estimated  forfeiture  rate  to  unvested  awards  for  the  purpose  of  calculating  compensation  cost.  These  estimates  will  be 
revised, if necessary, in future periods if actual forfeitures differ from estimates. Changes in forfeiture estimates impact compensation 
cost in the period in which the change in estimate occurs. The estimated forfeiture rates at March 31, 2011 and 2010 was zero as the 
Company has not had a significant history of forfeitures and does not expect forfeitures in the future.  

The Company uses Black-Scholes to estimate the fair value of stock-based awards. The determination of fair value using 
Black-Scholes is affected by its stock price as well as assumptions regarding a number of complex and subjective variables, including 
expected stock price volatility, risk-free interest rate, expected dividends and projected employee stock option exercise behaviors.  

At March 31, 2011, there was $286,821 of total unrecognized compensation cost related to non-vested stock options, which 

is expected to be recognized over a remaining weighted average vesting period of approximately 1.83 years.  

The Company’s stock-based compensation plans are discussed further in Note 11.  

F-11  

   
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Issuance of Stock for Non-Cash Consideration  

The  Company  accounts  for  equity  issuances  to  non-employees  in  accordance  with  accounting  guidance  for  equity 
instruments that are issued to other than employees for acquiring, or in conjunction with selling, goods and services. All transactions 
in which goods or services are the consideration received for the issuance of equity instruments are accounted for based on the fair 
value  of  the  consideration  received  or  the  fair  value  of  the  equity  instrument  issued,  whichever  is  more  reliably  measurable.  The 
measurement date used to determine the fair value of the equity instrument issued is the earlier of the date on which the third-party 
performance is complete or the date on which it is probable that performance will occur. See Note 12 for more details.  

Basic and Diluted Loss Per Share  

Basic loss per common share is computed based on the weighted average number of shares outstanding during the period. 
Diluted  loss  per  share  is  computed  by  dividing  net  loss  by  the  weighted  average  shares  outstanding  assuming  all  dilutive  potential 
common shares were issued. For the years ended March 31, 2011 and 2010, the Company was in a loss position and the basic and 
diluted loss per share are the same since the effect of stock options, warrants and convertible notes payable on loss per share was anti-
dilutive and thus not included in the diluted loss per share calculation. The impact under the treasury stock method of dilutive stock 
options  and  warrants  and  the  if-converted  method  of  convertible  debt  would  have  resulted  in  weighted  average  common  shares 
outstanding of 16,088,589 and 8,472,977 for the years ended March 31, 2011 and 2010, respectively.  

In addition, in computing the dilutive effect of convertible  securities, the numerator is adjusted  to  add back the after-tax 

amount of interest, if any, recognized in the period associated with any convertible debt.  

Segment Reporting  

We currently operate in only one segment.  

Subsequent Events  

The Company has evaluated subsequent events through the filing date of this Form 10-K and determined that no subsequent 
events have occurred that would require recognition in the consolidated financial statements or disclosure in the notes thereto other 
than as discussed in the accompanying notes.  

F-12  

   
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

New Accounting Pronouncements  

In August 2010, the FASB issued Accounting Standards Update (“ASU”) No. 2010-05, Measuring Liabilities at Fair Value, 
or ASU 2010-05, which amends ASC 820 to provide clarification of a circumstance in which a quoted price in an active market for an 
identical liability is not available. A reporting entity is required to measure fair value using one or more of the following methods: 1) a 
valuation  technique  that  uses  a)  the  quoted  price  of  the  identical  liability  when  traded  as  an  asset  or  b)  quoted  prices  for  similar 
liabilities (or similar liabilities when traded as assets) and/or 2) a valuation technique that is consistent with the principles of ASC 820. 
ASU  2010-05  also  clarifies  that  when  estimating  the  fair  value  of  a  liability,  a  reporting  entity  is  not  required  to  adjust  to  include 
inputs relating to the existence of transfer restrictions on that liability. The adoption did not have a material impact on our consolidated 
financial statements.  

In August 2010, the FASB issued an exposure draft on lease accounting that would require entities to recognize assets and 
liabilities arising from lease contracts on the balance sheet. The proposed exposure draft states that lessees and lessors should apply a 
“right-of-use model” in accounting for all leases. Under the proposed model, lessees would recognize an asset for the right to use the 
leased asset, and a liability for the obligation to make rental payments over the lease term. The lease term is defined as the longest 
possible term that is “more likely than not” to occur. The accounting by a lessor would reflect its retained exposure to the risks or 
benefits of the underlying leased asset. A lessor would recognize an asset representing its right to receive lease payments based on the 
expected term of the lease. Comments on this exposure draft were due by December 15, 2010 and the final standard is expected to be 
issued in the second quarter of 2011. The Company does not expect the proposed standard, as currently drafted, will have a material 
impact on its consolidated financial statements.  

Note 2. Inventories  

Inventories consist of the following:  

Raw materials  
Finished goods  

   March 31,       March 31,    

2011 

2010 

$ 

$ 

37,739     
6,485     
44,224     

$ 

$ 

—  
—  
—  

The  Company’s  inventories  consists  of  accessories  that  are  sold  and  shipped  to  customers  along  with  pay-per-use 
containers  and  are  not  returned  to  the  Company  along  with  the  containers  at  the  culmination  of  the  customer’s  shipping  cycle. 
Inventories  are  stated  at  the  lower  of  standard  cost  or  current  estimated  market  value.  Cost  is  determined  using  the  standard  cost 
method which approximates the first-in, first-to-expire method.  

Note 3. Property and Equipment  

Equipment and leasehold improvements and related accumulated depreciation and amortization are as follows:  

Cryogenic shippers  
Furniture and fixtures  
Machinery and equipment  
Leasehold improvements  

Less accumulated depreciation and amortization  

March 31, 

$ 

2011 
689,757     
3,284     
355,303     
19,426     

   1,067,770     
(398,190 )   
669,580     

$ 

2010 
449,734   
3,284   
340,169   
19,426   

812,613   
(253,372 ) 
559,241   

$ 

$ 

During  its  early  years,  the  Company’s  limited  revenue  was  derived  from  the  sale  of  our  reusable  product  line.  The 
Company’s current business plan focuses on per-use leasing of shipping containers and added-value services that will be used by us to 
provide an end-to-end and cost-optimized shipping solutions.  

Total depreciation and amortization expense related to property and equipment amounted to $164,316 and $80,746 for the 

years ended March 31, 2011 and 2010, respectively.  

   
  
  
    
    
    
  
  
  
  
    
  
   
  
    
    
    
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
  
  
  
  
  
  
  
  
    
    
    
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
   
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
  
  
  
  
  
  
F-13  

Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 4. Intangible Assets  

Intangible assets are comprised of patents and trademarks and software developed for internal uses. The gross book values 

and accumulated amortization as of March 31, 2011 and 2010 were as follows:  

Patents and trademarks  
Software development costs  

Less accumulated amortization  

March 31, 

2011 

2010 

$ 

91,354     
479,131     
570,485     
(215,631 )   

$ 

91,354   
355,081   
446,435   
(134,470 ) 

$ 

354,854     

$ 

311,965   

Amortization  expense  for  intangible  assets  for  the  years  ended  March 31,  2011  and  2010  was  $81,161  and  $69,347, 

respectively. All of the Company’s intangible assets are subject to amortization.  

Years Ending March 31, 

2012  
2013  
2014  
2015  
2016  

Patents and     
   Trademarks     

Software 

Total 
Intangibles   

$ 

$ 

8,533     
8,533     
8,506     
7,460     
7,047     

$ 

95,804     
95,804     
77,116     
29,253     
16,798     

104,337   
104,337   
85,622   
36,713   
23,845   

$ 

40,079     

$ 

314,775     

$ 

354,854   

F-14  

   
  
  
    
    
    
  
  
  
  
  
  
    
  
   
  
    
    
    
  
  
  
  
  
    
  
  
  
  
  
  
   
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
   
  
    
  
  
  
  
  
  
  
  
    
    
    
    
    
  
  
  
    
    
  
    
   
  
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
    
    
    
    
    
  
   
  
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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 5. Fair Value Measurements  

The  Company  determines  the  fair  value  of  its  derivative  instruments  using  a  three-level  hierarchy  for  fair  value 
measurements  which  these  assets and liabilities  must be grouped,  based on  significant levels  of  observable or unobservable  inputs. 
Observable  inputs  reflect market data  obtained  from  independent sources,  while  unobservable inputs  reflect  the Company’s market 
assumptions. This hierarchy requires the use of observable market data when available. These two types of inputs have created the 
following fair-value hierarchy:  

Level  1  —  Valuations based  on  unadjusted  quoted  market  prices  in active  markets  for identical  securities. Currently the 

Company does not have any items classified as Level 1.  

Level 2 — Valuations based on observable inputs (other than Level 1 prices), such as quoted prices for similar assets at the 

measurement date; quoted prices in markets that are not active; or other inputs that are observable, either directly or indirectly.  

Level  3  —  Valuations  based  on  inputs  that  are  unobservable  and  significant  to  the  overall  fair  value  measurement,  and 
involve  management  judgment.  The  Company  uses  the  Black-Scholes  option  pricing  model  to  determine  the  fair  value  of  the 
instruments. If the inputs used to measure fair value fall in different levels of the fair value hierarchy, a financial security’s hierarchy 
level is based upon the lowest level of input that is significant to the fair value measurement.  

The following table presents the Company’s warrants measured at fair value on a recurring basis as of March 31, 2011 and 

March 31, 2010 classified using the valuation hierarchy:  

Derivative Liabilities  

Level 3 

Level 3 

   Carrying Value      Carrying Value   
   March 31, 2011      March 31, 2010   

   $ 

156,497      $ 

334,363   

The following table provides a reconciliation of the beginning and ending balances for the Company’s derivative liabilities 

measured at fair value using Level 3 inputs:  

Balance at April 1  
Cumulative effect of change in accounting principle (see Note 9)  
Derivative liability added — warrants  
Derivative liability added — conversion option  
Reclassification of conversion feature to equity upon conversions of notes  
Reclassification of conversion feature and warrants to equity upon modification of terms (no 

longer derivative instruments)  

Change in fair value  
Reclassification of warrants to equity upon fixing exercise price  

Balance at March 31,  

$ 

2011 
334,363     
—    
—    
—    
—    

2010 

$ 
—  
   16,470,718   
389,781   
788,631   
   (2,728,459 ) 

—    
(49,590 )   
(128,276 )   

   (9,009,329 ) 
   (5,576,979 ) 
—  

$ 

156,497     

$ 

334,363   

F-15  

   
  
  
     
    
     
  
  
  
    
  
  
  
   
  
     
    
     
  
    
  
  
  
  
  
  
  
  
    
    
    
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
  
  
  
  
  
  
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Note 6. Line of Credit  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

On  November 5,  2007,  the  Company  secured  financing  for  a  $200,000  one-year  revolving  line  of  credit  (the  “Line”) 
secured  by  a  $200,000  certificate  of  deposit  with  a  financial  institution.  On  November 6,  2008,  the  Company  secured  a  one-year 
renewal  of  the  Line  for  a  reduced  amount  of  $100,000  which  is  secured  by  a  $100,000  certificate  of  deposit  with  a  financial 
institution.  During  October 2010,  the  Company  secured  a  one-year  renewal  of  the  Line  for  a  reduced  amount  of  $90,000  which  is 
secured by a $90,000 certificate of deposit with a financial institution. All borrowings under the revolving line of credit bear variable 
interest based either the prime rate plus 1.5% per annum (totaling 4.75% as of March 31, 2011) or 5.0%, whichever is higher. The 
Company  utilizes  the  funds  advanced  from  the  Line  for  capital  equipment  purchases  to  support  the  commercialization  of  the 
Company’s CryoPort Express ® One-Way Shipper. As of March 31, 2011 and 2010, the outstanding balance of the Line was $90,388, 
including  accrued  interest  of  $388.  No  funds  were  drawn  against  the  Line  during  the  years  ended  March 31,  2011  or  2010.  The 
Company recorded interest expense of $4,563 and $4,094 for the years ended March 31, 2011 and 2010, respectively.  

Note 7. Related Party Transactions  

Related Party Notes Payable  

As of March 31, 2011 and 2010, the Company had aggregate principal balances of $849,500 and $1,009,500, respectively, 
in  outstanding  unsecured  indebtedness  owed  to  five  related  parties,  including  four  former  members  of  the  board  of  directors, 
representing working capital advances made to the Company from February 2001 through March 2005. These notes bear interest at 
the  rate  of  6%  per  annum and  provide  for  aggregate  monthly  principal  payments  which  began  April 1,  2006  of  $2,500,  and  which 
increased by an aggregate of $2,500 every nine months to a maximum of $10,000 per month. As of March 31, 2011, the aggregate 
principal payments totaled $10,000 per month. Any remaining unpaid principal and accrued interest is due at maturity on March 1, 
2015.  

Related-party interest expense under these notes was $57,156 and $64,496 for the years ended March 31, 2011 and 2010, 
respectively.  Accrued  interest  related  to  these  notes,  which  is  included  in  related  party  notes  payable  in  the  accompanying 
consolidated balance sheets, amounted to $675,912 and $618,756 as of March 31, 2011 and 2010, respectively.  

Scheduled maturities of related party debt as of March 31, 2011 are as follows:  

Years Ending March 31:  
2012  
2013  
2014  
2015  

Note Payable to Former Officer  

$ 

102,000   
96,000   
96,000   
   1,231,412   

$  1,525,412   

In August 2006, Peter Berry, the Company’s former Chief Executive Officer, agreed to convert his deferred salaries to a 
long-term note payable. Interest of 6% per annum on the outstanding principal balance of the note began to accrue on January 1, 2008. 
Under the terms of this note, the Company began to make monthly payments of $3,000 to Mr. Berry in January 2007. The note and a 
portion  of  the  accrued  interest  were  paid  in  March 2010  and  the  remaining  accrued  interest  of  $11,996  was  paid  in  full  in 
August 2010. Interest expense related to this note was $11,996 and $8,133 for the years ended March 31, 2011 and 2010, respectively. 
In February 2009, Mr. Berry resigned his position as Chief Executive Officer and on July 30, 2009. Mr. Berry resigned his position 
from the Board.  

Consulting Agreement with Former Officer  

On  March 1,  2009,  the  Company  entered  into  a  Consulting  Agreement  with  Peter  Berry,  the  Company’s  former  Chief 
Executive  Officer.  Mr. Berry  provided  the  Company  with  consulting  services  as  an  independent  contractor,  for  a  ten  (10) month 
period from March 1, 2009 through December 31, 2009, as an advisor to the Chief Executive Officer and the Board of Directors.  

Related-party  consulting  fees  for  these  services  were  $0  and  $292,010  for  the  years  ended  March 31,  2011  and  2010, 

respectively.  

Advisory Services Agreement with Former Officer  

On  March 7,  2011  the  Company  entered  into  a  one-year  Advisory  Services  Agreement  with  Marc  Grossman  M.D.  to 
provide strategic business advisory services including identifying and introducing customers, advising on sales and marketing plans 

  
  
    
  
  
    
  
  
  
  
  
  
  
    
  
  
  
   
  
    
  
   
  
    
  
  
  
and providing financial advice. Dr. Grossman is a former officer of the Company and is one of the five related parties to 
which CryoPort has an outstanding unsecured debt obligation. For these services, Dr. Grossman was paid a fee of $125,000, which is 
to be amortized over the term of the agreement, and issued a warrant to purchase 200,000 shares of the Company’s common stock at 
an exercise price of $0.77 per share and vested upon issuance. The fair value of this warrant was $302,769 of which the Company 
recorded $277,538 as another current asset and recognized $25,231 in selling, general and administrative expense for the year ended 
March 31, 2011 in the accompanying consolidated financial statements.  

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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Related Party Legal Services  

Since June 2005, the Company had retained the legal services of Gary C. Cannon, Attorney at Law, for a monthly retainer 
fee. From June 2005 to May 2009, Mr. Cannon also served as the Company’s Secretary and a member of the Company’s Board of 
Directors.  Mr. Cannon  continued  to  serve  as  Corporate  Legal  Counsel  for  the  Company  and  served  as  a  member  of  the  Advisory 
Board.  In  December 2007,  Mr. Cannon’s  monthly  retainer  for  legal  services  was  increased  from  $6,500  per  month  to  $9,000  per 
month. The total amount paid to Mr. Cannon for retainer fees and out-of-pocket expenses for the year ended March 31, 2011 and 2010 
was $0 and $34,350, respectively. Board fees expensed for Mr. Cannon were $0 and $5,388 for the years ended March 31, 2011 and 
2010,  respectively.  At  March 31,  2011  and  2010,  $0  and  $7,788,  respectively,  of  deferred  board  fees  was  included  in  accrued 
compensation and related expenses. During the year ended March 31, 2010, Mr. Cannon was granted a total of 2,557 warrants with an 
average exercise price of $5.90 per share. All warrants granted to Mr. Cannon were issued with an exercise price of greater than or 
equal to the stock price of the Company’s shares on the grant date. On May 4, 2009, Mr. Cannon resigned from the Company’s Board 
of Directors and in July 2009 Mr. Cannon was given 30 days notice that he was terminated as the general legal counsel and advisor to 
the Company.  

Consulting Agreement with Officer  

On July 29, 2009, the Board of Directors of the Company appointed Ms. Catherine M. Doll, a consultant, to the offices of 

Chief Financial Officer, Treasurer and Assistant Corporate Secretary, which became effective on August 20, 2009.  

Ms. Doll  is  the  owner  and  chief  executive  officer  of  The  Gilson  Group,  LLC.  The  Gilson  Group,  LLC  provided  the 
Company  financial  and  accounting  consulting  services  including,  SEC  and  financial  reporting  including  the  filing  of  the  S-1, 
budgeting and forecasting and finance and accounting systems implementations and conversions.  

Related-party consulting fees for these services were $437,796 and $234,650 for the years ended March 31, 2011 and 2010, 
respectively. On October 9, 2009, the Compensation and Governance Committee granted Ms. Doll an option to purchase 2,000 shares 
of common stock at an  exercise price of  $4.50 per share (the closing price of the  Company’s stock on the date of grant) valued at 
$8,480  as  calculated  using  Black-Scholes  and  is  included  in  selling,  general  and  administrative  expense  in  the  accompanying 
consolidated  statements  of  operations.  The  assumptions  used  under  Black-Scholes  included:  a  risk  free  rate  of  2.36%;  volatility  of 
182%; an expected exercise term of 4.25 years; and no annual dividend rate. The right to exercise the stock options vested as to 33 
1/3% of the underlying shares of common stock upon grant, with the remaining underlying shares vesting in equal installments on the 
first and second anniversary of the grant date.  

Note 8. Convertible Debentures Payable  

The Company’s convertible debenture balances are shown below:  

October 2007 Debentures  
May 2008 Debentures  

Debt discount  
Total convertible debentures, net of discount  

   March 31,       March 31,    

2011 
$  2,607,196     
—    
   2,607,196     
(206,068 )   
$  2,401,128     

2010 
$  3,150,975   
79,593   
   3,230,568   
(728,109 ) 
$  2,502,459   

Short-term:  
Current portion of convertible debentures payable, net of discount of $197,226 in 2011 and $0 in 

2010, respectively  

Long-term:  
Convertible debentures payable, net of current portion and discount of $8,842 in 2011 and 

$728,109 in 2010, respectively  

Total convertible debentures, net of discount  

   1,979,402     

200,000   

421,726     
$  2,401,128     

   2,302,459   
$  2,502,459   

During the years ended March 31, 2011 and 2010, the Company recognized an aggregate of $522,041 and $6,417,346 in 
interest  expense,  respectively,  due  to  amortization  of  debt  discount  related  to  the  warrants  and  embedded  conversion  features 
associated with the Company’s outstanding convertible debentures.  

October 2007 and May 2008 Debentures  

The  Company  issued  convertible  debentures  in  October 2007  (the  “October 2007  Debentures”)  and  in  May 2008  (the 
“May 2008  Debentures,”  and  together  with  the  October 2007  Debentures,  the  “Debentures”).  The  Debentures  were  issued  to  four 

  
  
    
    
    
  
  
  
  
    
  
  
  
  
  
    
  
  
  
  
  
  
   
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
    
    
  
  
    
    
    
  
  
  
  
    
    
    
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
institutional investors  and  had  an  outstanding  principal balance  of  $2,607,196 and $3,230,568  as  of  March 31, 2011  and 
2010,  respectively.  In  addition,  in  October 2007  and  May 2008,  the  Company  issued  to  these  institutional  investors  warrants  to 
purchase, as of March 31, 2011, an aggregate of 3,055,097 shares of the Company’s common stock (the “Debenture Warrants”). As 
collateral to secure our repayment obligations to the holders of the Debentures we have granted such holders a first priority security 
interest in generally all of our assets, including our intellectual property.  

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Table of Contents  

Fiscal Year 2010 Activity  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

During the year ended March 31, 2010, the Company converted interest payments due on the Debentures totaling $171,253 

into 42,814 shares of common stock using the conversion rate of $4.00.  

In  May 2009,  approximately  $713,000  of  the  October 2007  Debentures  was  converted  by  a  note  holder.  Using  the 
conversion rate  of $5.10 per share per the terms of the debenture, 139,804 shares  of common stock were  issued to the investor. In 
addition, the fair value of $593,303 related to the conversion feature was reclassified from the liability for derivative instruments to 
additional paid-in capital (see Note 10) and accelerated the recognition of $508,886 of unamortized debt discount as interest expense.  

On  July 30,  2009,  the  Company  entered  into  a  Consent,  Waiver  and  Agreement  with  the  holders  of  the  Debentures  (the 
“July Agreement”). Pursuant to the terms of the July Agreement, the Holders (i) consented to the Company’s issuance of convertible 
notes  and  warrants  in  connection  with  a  bridge  financing  of  up  to  $1,500,000  which  commenced  in  March 2009  (the  “Bridge 
Financing”),  and (ii)  waived,  as  it relates to  the  Bridge Financing,  a covenant  contained  in the  Debentures  not  to  incur  any further 
indebtedness, except as otherwise permitted by the Debentures. This Bridge Financing is more particularly described below under the 
caption  “Private Placement  Debentures.”  In addition,  in connection with  the  July Agreement,  the  Company and Holders confirmed 
that (i) the exercise price of the Debenture Warrants had been reduced, pursuant to the terms of the Debenture Warrants, to $5.10 as a 
result  of  the  Bridge  Financing,  and  (ii) as  a  result  of  the  foregoing  decrease  in  the  exercise  price,  pursuant  to  the  terms  of  the 
Debenture  Warrants,  the  number  of  shares  underlying  the  Debenture  Warrants  held  by  Holders  of  the  Debentures  had  been 
proportionally  increased  by  404,350  pursuant to the  terms of the warrant agreements. As a result of  the foregoing adjustments,  the 
Company recognized a loss in other expense due to the change in fair value of derivative liabilities of $1,608,540 and a corresponding 
increase to the liability for derivative instruments.  

On  September 17,  2009,  the  Company  entered  into  an  Amendment  to  Debentures  and  Warrants,  Agreement  and  Waiver 
(the  “September  Amendment”)  with  the  holders  of  the  Company’s  outstanding  Debentures  and  associated  Debenture  Warrants  to 
purchase  common  stock,  as  such  Debentures  and  Debenture  Warrants  have  been  amended.  The  effective  date  of  the  September 
Amendment was September 1, 2009. The purpose of the September Amendment was to restructure the Company’s obligations under 
the  outstanding  Debentures  in  order  to  reduce  the  amount  of  the  required  monthly  principal  payment  and  temporarily  defer  the 
commencement  of  monthly  principal  payments  (which  was  scheduled  to  commence  September 1,  2009)  and  ceased  the  continuing 
interest payments for a period time. The following is a summary of the material terms of the September Amendment:  

1. The Company was required to obtain stockholder approval of an amendment to its Amended and Restated Articles of 
Incorporation to increase the number of authorized shares of its common stock to 250,000,000. Such approval was obtained 
at  the  shareholders’  meeting  on  October 9,  2009,  and  an  amendment  was  filed  with  the  Nevada  Secretary  of  State  on 
November 2, 2009.  

2. As of September 1, 2009, the principal amount of the Debentures was increased by $482,792, which was added to the 
outstanding principal balances and $403,214 was recorded as a debt discount and is being amortized over the remaining life 
of the Debentures. The increase reflected all accrued and unpaid interest as of such date, plus all interest that would have 
accrued on the principal amount (as increased as of September 1, 2009, to reflect the then accrued but unpaid interest) from 
September 1,  2009,  to  July 1,  2010  (the  maturity  date  of  the  Debentures).  The  Company  had  no  obligation  under  the 
Debentures  to  make  further  payments  of  interest,  and  interest  ceased  to  accrue,  during  the  period  September 1,  2009  to 
July 1, 2010.  

3.  The  conversion  price  of  the  Debentures  was  decreased  from  $5.10  per  share  to  $4.50  per  share,  which  resulted  in  an 
increase in the number shares of common stock which the Debentures may be converted into, an increase in the liability for 
derivative instruments of $802,200 and a corresponding loss was recorded in other expense, net due to the change in fair 
value of derivatives.  

4.  The  commencement  of  the  Company’s  obligation  to  make  monthly  payments  of  principal  was  deferred  from 
September 1, 2009, to January 1, 2010, at which time the Company was to make monthly pro rata payments to the Holders 
in  the  aggregate  amount  of  $200,000  with  a  balloon  payment  due  on  the  maturity  date  of  July 1,  2010.  Prior  to  the 
Amendment, the Company was obligated to repay the entire outstanding principal amount of the debentures in twelve equal 
monthly  payments  commencing  on  August 1,  2009.  On  January 12,  2010,  the  Company  entered  into  an  Amendment  to 
Debentures and Warrants, Agreement and Waiver with the Holders of the Company Debentures, which was subsequently 
amended in February 2010 as discussed below.  

5. The Holders’ existing right to maintain a fully diluted ownership equal to 31.5% has been increased by the Amendment 
to a fully diluted ownership of 34.5%.  

   
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Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

6. The exercise price of the outstanding Debenture Warrants was decreased from $5.10 per share to $4.50 per share, which 
also  resulted  in  a corresponding  pro  rata  increase in  the number  of  shares  that  would  be  purchased  upon  exercise  of  the 
Debenture  Warrants  to  an  aggregate  of  3,055,095  shares.  The  reduction  in  exercise  price  of  the  Debenture  Warrants  to 
$4.50 per share and the 359,423 share increase in the number of Debenture Warrants resulted in an increase in the liability 
for derivative instruments of $1,679,990 and a corresponding loss was recorded in other expense, net due to the change in 
fair value of derivative liabilities.  

7. The following additional covenants were added to the Debentures (replacing similar covenants which had terminated as 
of June 30, 2009) and remained in full force so long as any of the Debentures remain outstanding (the “Covenant Period”):  

a.  The  Company  was  to  maintain  a  total  cash  balance  of  no  less  than  $100,000  at  all  times  during  the  Covenant 
Period;  

b. The Company was to have an average monthly operating cash burn of no more than $500,000 during the Covenant 
Period. Operating cash burn was defined by taking net income (or loss), added back all non-cash items, and excluded 
changes in assets, liabilities and financing activities;  

c.  The  Company  was  to  have  a  minimum  current  ratio  of  0.5  to  1  at  all  times  during  the  Covenant  Period.  This 
calculation was to be made by excluding the current portion of the convertible notes payable and accrued interest, and 
liability from derivative instruments from current liability for the current ratio;  

d. Accounts payable was not to exceed $750,000 at any time during the Covenant Period;  

e. Accrued salaries was not to exceed $350,000 at any time during the Covenant Period; and  

f. The Company was not make any revisions to the terms of the existing contractual agreements for the Notes Payable 
to Former Officer, Related Party Notes Payable and the Line of Credit (as each is referred to in the Company’s Form 
10-Q for the period ended June 30, 2009); other than the previous amendment to the payment terms of a note payable 
to the Company’s former CEO.  

8. The Company was not to deliver a redemption notice with respect to the outstanding Debentures until such time as the 
closing  price  of  the  Company’s  common  stock  shall  have  exceeded  $7.00  (as  adjusted  for  stock  splits  or  similar 
transactions) for ten consecutive trading days prior to the delivery of the redemption notice.  

On September 22, 2009, the holders of the October 2007 Debentures converted $100,000 of principal into 22,222 shares of 
the Company’s common stock at a conversion price of $4.50. As a result of the conversion, the Company reclassified $52,799 of the 
derivative liability related to the embedded conversion feature to additional paid-in capital and accelerated the recognition of $41,277 
of unamortized debt discount as interest expense.  

On  October 9,  2009,  the  holders  of  the  October 2007  Debentures  converted  $90,000  principal  into  20,000  shares  of  the 
Company’s  common  stock  at  a  conversion  price  of  $4.50.  As  a  result  of  the  conversion,  the  Company  reclassified  $37,001  of  the 
derivative liability related to the embedded conversion feature to additional paid-in capital and accelerated the recognition of $33,708 
of unamortized debt discount as interest expense.  

On November 17, 2009, the holders of the October 2007 Debentures converted $180,000 principal into 40,000 shares of the 
Company’s  common  stock  at  a  conversion  price  of  $4.50.  As  a  result  of  the  conversion,  the  Company  reclassified  $80,368  of  the 
derivative liability related to the embedded conversion feature to additional paid-in capital and accelerated the recognition of $59,262 
of unamortized debt discount as interest expense.  

On November 24, 2009, the holders of the October 2007 Debentures converted $100,000 principal into 22,222 shares of the 
Company’s  common  stock  at  a  conversion  price  of  $4.50.  As  a  result  of  the  conversion,  the  Company  reclassified  $38,224  of  the 
derivative liability related to the embedded conversion feature to additional paid-in capital and accelerated the recognition of $32,034 
of unamortized debt discount as interest expense.  

On January 11, 2010, the holders of the October 2007 Debentures converted $100,000 principal into 22,222 shares of the 
Company’s  common  stock  at  a  conversion  price  of  $4.50.  As  a  result  of  the  conversion,  the  Company  reclassified  $88,001  of  the 
derivative liability related to the embedded conversion feature to additional paid-in capital and accelerated the recognition of $25,989 
of unamortized debt discount as interest expense.  

On January 15, 2010, the holders of the October 2007 Debentures converted $100,000 principal into 22,222 shares of the 
Company’s common stock at a conversion price of $4.50. As a result of the conversion, the Company reclassified $114,693 of the 
derivative liability related to the embedded conversion feature to additional paid-in capital and accelerated the recognition of $25,451 
of unamortized debt discount as interest expense.  

On February 19, 2010, the Company entered into an Amended and Restated Amendment Agreements with the holders of 
the Company’s Debentures (as hereinafter defined), which was amended on February 23, 2010 (collectively, the “2010 Amendment”), 
pursuant to which the Company amended and restated the amendment agreements entered into on January 12, 2010 and February 1, 
2010  with  the  holders.  Pursuant  to  the  2010  Amendment,  the  debenture  holders  confirmed  their  prior  agreement  to  defer  until 
March 1, 2010 the Company’s obligation to make the January 1, 2010 and February 1, 2010 debenture amortization payments (each in 
the aggregate amount of $200,000) and their consent to the Company’s recent 10-to-1 reverse stock split. The following is a summary 
of the material terms of the 2010 Amendment:  

• 

• 

  each holder converted $1,357,215 in principal amount of the outstanding principal balance of such holder’s debenture in 
exchange for a number of shares of common stock determined by dividing such principal amount by the unit offering price 
in  the  Company’s  equity  financing  on  February 25, 2010  (see  Note  10).  Based  on the  public  offering price  of  $3.00 per 
unit, each holder received a total of 452,405 shares of common stock upon conversion. As a result of the conversion of an 
aggregate of $2,714,430 outstanding principal, the Company reclassified a portion of the derivative liability related to the 
conversion feature of the Debentures of $1,450,605 to additional paid-in capital and accelerated the recognition of $554,720 
of debt discount as interest expense;  

  with respect to the remaining outstanding balance of the debentures after the foregoing conversions, the Company is not 
obligated to make any principal or interest payments until March 1, 2011, at which time the Company will be obligated to 
start making monthly principal payments of $200,000 for a period of seventeen (17) months with a final balloon payment 
due on August 1, 2012. In addition, the future interest of $163,573 (in the aggregate) that would accrue on the outstanding 
principal balance from July 1, 2010 (the date to which accrued interest was previously added to principal) to March 1, 2011 
was  added  to  the  current  principal  balance  of  the  debentures  with  a  corresponding  increase  to  the  debt  discount  to  be 
amortized  over  the  remaining  life  of  the  debt.  Interest  payments  over  the  remaining  term  are  to  accrue  and  become  due 
quarterly;  

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Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

• 

  the conversion price of the remaining outstanding balance of each debenture was reset to $3.00 based on the public offering 

price;  

• 

• 

• 

• 

  the exercise price of the warrants currently held by the debenture holders was reset to $3.30 per share which is equal to the 
exercise price of the warrants included as part of the units sold in the public offering (110% of the unit offering price) and 
the exercise period was extended to January 1, 2015;  

  the termination of certain anti-dilution provisions contained in the debentures and warrants held by the debenture holders 
and their right to maintain a fully-diluted ownership of our common stock equal to 34.5%, which, along with the reset of 
the  conversion  price  to  $3.00  per  share  and  warrant  exercise  price  to  $3.30  per  share,  resulted  in  the  reclassification  of 
$9,009,329  of  derivative  liability  related  to  the  embedded  conversion  features  and  warrants  to  additional  paid-in  capital 
since the modification to the terms of the warrants no longer required derivative accounting;  

  the termination of certain financial covenants as described above; and  

  each executed a lock-up agreement covering a period of 180 days following the effective date of the registration statement; 
provided, however, that in the event that on any trading day during the lock-up period the trading price of the Company’s 
common stock exceeds 200% of the offering price of the units, then each holder may sell at sales prices equal to or greater 
than 200% of such unit offering price a number of shares of common stock on that trading day (such day referred to as an 
“Open Trading Day”) equal to up to 10% of the aggregate trading volume of the Company’s common stock on the primary 
market on which it is trading on such Open Trading Day, and (ii) in the event on any trading day during the lock-up period 
the  trading  price  of  the  Company’s  common  stock  exceeds  300%  of  the  unit  offering  price  (also referred  to  as  an  Open 
Trading Day), each holder may sell at sales prices equal to or greater than 300% of such unit offering price an unlimited 
number of shares of common stock on such Open Trading Day. Sales under the foregoing clause (ii) on any particular Open 
Trading Day shall not be aggregated with sales under the foregoing clause (i) on the same Open Trading Day for purposes 
of calculating the 10% limitation under clause (i).  

Fiscal Year 2011 Activity  

During January 2011, the holders of the October 2007 Debentures converted $200,000 principal into 66,666 shares of the 
Company’s common stock at a conversion price of $3.00 per share per the terms of the Debentures. For the year ending March 31, 
2011 aggregate principal payments were $343,779.  

As of March 31, 2011, the May 2008 Debentures were paid in full. For the year ending March 31, 2011 aggregate principal 

payments were $79,593.  

Private Placement Debentures  

Fiscal Year 2010 Activity  

In  March 2009,  the  Company  entered  into  an  Agency  Agreement  with  a  broker  to  raise  capital  in  a  private  placement 
offering of one-year convertible debentures pursuant to Regulation D of the Securities Act of 1933 and the Rules promulgated there 
under  (the  “Private  Placement  Debentures”).  As  of  March 31,  2010,  the  Company  had  received  total  gross  proceeds  of  $1,381,500 
under this private placement offering of convertible debentures which included gross proceeds of $1,321,500 raised during the year 
ended March 31, 2010. The Company had the option to make principal redemptions on the maturity dates of the debentures in shares 
of common stock at a conversion price of  $5.10 per share.  At any time, holders were able to convert the debentures into shares of 
common stock at the conversion price of $5.10. The conversion price was subject to adjustment in the event the Company issued its 
next equity financing of at least $2,500,000 at a price below $5.10 per share. Per the terms of the convertible debenture agreements, 
the notes had a term of one year from issuance and were redeemable by the Company with two days notice. The notes bore interest at 
8%  per  annum  and  were  convertible  into  shares  of  the  Company’s  common  stock  at  a  conversion  rate  of  $5.10  per  share.  In 
connection  with  the  Private  Placement  Debentures,  the  Company  issued  to  investors  an  aggregate  of  54,177  five-year  warrants  to 
purchase  shares  of  the  Company’s  common  stock  at  $5.10  per  share  (the  “Private  Placement  Warrants”),  which  included  51,824 
warrants issued to investors during the year ended March 31, 2010, and were accounted for as derivative liabilities (see Note 9). The 
Company had determined the aggregate fair value of the issued warrants as of the dates of each grant, based on Black-Scholes, to be 
approximately $291,570 for the year ended March 31, 2010. The exercise price of the warrants was subject to adjustment in the event 
the Company issued its next equity financing of at least $2,500,000 at a price below $5.10 per share. In connection with the issuance 
of the Private Placement Debentures, the Company recognized a debt discount and derivative liability at the dates of issuance in the 
aggregate  amount  of  $1,125,772  related  to  the  fair  value  of  the  warrants  and  embedded  conversion  features,  which  included 
$1,080,201 of debt discount recorded during the year ended March 31, 2010 comprised of $788,631 related to the fair value of the 
embedded  conversion  features  and  $291,570  related  to  the  fair  value  of  the  warrants.  Prior  to  conversion  (see  below),  the  debt 
discount  was  amortized  to  interest  expense  over  the  life  of  the  debentures  and  the  derivative  liability  was  revalued  each  reporting 
period with changes in fair value recognized in earnings.  

  
  
  
  
  
  
  
  
  
On  February 25,  2010,  immediately  prior  to  the  Company’s  public  offering,  the  holders  of  the  Private  Placement 
Debentures  converted  the  principal  balance  of  $1,381,500  and  accrued  interest  of  $78,701  into  519,187  shares  of  the  Company’s 
common  stock  at  a  conversion  price  of  $2.81  in  prepayment  of  all  amounts  due.  As  a  result  of  the  conversion,  the  Company 
reclassified  the  derivative  liability  related  to  the  conversion  feature  of  the  Private  Placement  Debentures  of  $273,465  to  additional 
paid-in capital and recognized the remaining debt discount of approximately $331,002 as interest expense. In addition, pursuant to the 
anti-dilution provisions contained in the Private Placement Warrant agreements, the exercise price of the Private Placement Warrants 
was  reset  from  $5.10  per  share  to  $2.81  per  share  and  the  Company  recorded  a  loss  of  $2,756  in  other  expense,  net  and  a 
corresponding  increase  in  derivative  liabilities.  The  derivative  liabilities  balance  of  $128,276  related  to  the  Company’s  Private 
Placement Warrants was reclassified to additional paid-in capital in 2011 (see Note 9). During the year ended March 31, 2010, the 
Company issued 16,253 warrants with an exercise price of $5.10 per share for commissions due in connection with the Company’s 
Private Placement Debentures. The Company determined the aggregate fair value of the issued warrants, based on the Black-Scholes 
pricing model, to be $63,396, or $3.90 per share as of the effective date of grant, and was recorded in equity with a corresponding 
charge to deferred financing fees to be amortized to interest expense over the remaining life of the debt. The remaining balance of 
$21,132 was charged to interest expense upon conversion of the Private Placement Debentures in February 2010.  

During  the  year  ended  March 31,  2010,  the  Company  recognized  an  aggregate  of  $1,125,772  in  interest  expense  due  to 
amortization of debt discount related to the warrants and embedded conversion features associated with the Company’s outstanding 
Private Placement Debentures.  

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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Convertible debentures mature in fiscal years ending after March 31, 2011 as follows:  

Years Ending March 31,  
2012  
2013  

Note 9. Derivative Liabilities  

Amount 

$  2,176,628   
430,568   

$  2,607,196   

The Company’s derivative liabilities balance as of March 31, 2011 and 2010 was $156,497 and $334,363, respectively.  

During 2010, the Company adopted a new accounting guidance which requires certain instruments to be accounted for as 
derivative liabilities. In accordance with this guidance, the Company’s outstanding warrants to purchase shares of common stock and 
embedded  conversion  features  in  convertible  notes  payable  previously  treated  as  equity  were  no  longer  afforded  equity  treatment 
because these instruments have reset or ratchet provisions that are triggered in the event the Company raises additional capital at a 
lower price, among other adjustments. As such, effective April 1, 2009 the Company reclassified the fair value of these common stock 
purchase warrants and embedded conversion features, from equity to liability status as if these warrants and conversion features were 
treated as derivative liabilities since their dates of issuance or modification. Any change in fair value subsequent to April 1, 2009 is 
recorded as non-operating, non-cash income or expense at each reporting date. If the fair value of the derivatives was higher at the 
subsequent balance sheet date, the Company recorded a non-operating, non-cash charge. If the fair value of the derivatives was lower 
at the subsequent balance sheet date, the Company recorded non-operating, non-cash income. The cumulative effect at April 1, 2009 
to  record,  at  fair  value,  a  liability  for  the  warrants  and  embedded  conversion  features,  and  related  adjustments  to  discounts  on 
convertible notes of $2,595,095, resulted in an aggregate reduction to equity of $13,875,623 consisting of a reduction to additional 
paid-in  capital  of  $4,217,730  and  an  increase  in  the  accumulated  deficit  of  $9,657,893  to  reflect  the  adoption  of  new  accounting 
guidance.  

Fiscal Year 2010 Activity  

In July 2009, as a result of the July Agreement, the exercise price of the Debenture Warrants was decreased from $6.00 per 
share to $5.10 per share, which resulted in an increase in the liability for derivative instruments of $1,608,540 and a corresponding 
loss was recorded in other expense, net due to the change in fair value of derivative liabilities (see Note 8).  

In September 2009, as a result of the September Amendment, the conversion price of the Debentures and the exercise price 
of the Debenture Warrants  was  decreased  from $5.10 per  share to $4.50 per  share,  pursuant to the  terms of the Debentures,  which 
resulted  in  an  aggregate increase in the liability for derivative instruments of  $1,679,990 and  a corresponding loss was recorded  in 
other  expense,  net  due  to  the  change  in  fair  value  of  derivative  liabilities.  In  addition,  the  conversion  price  of  the  Debentures  was 
decreased from $5.10 per share to $4.50 per share, which resulted in an increase in the number shares of common stock which the 
Debentures may be converted into, an increase in the liability for derivative instruments of $802,200 and a corresponding loss was 
recorded in other expense, net and included in the change in fair value of derivative liabilities (see Note 8).  

In February 2010, as a result of the conversion of all outstanding amounts due under the Private Placement Debentures, the 
Company  reclassified  the  derivative  liability  for  the  embedded  conversion  feature  of  $273,465  to  additional  paid-in  capital.  In 
addition,  pursuant  to  the  anti-dilution  provisions  contained  in  the  Private  Placement  Warrant  agreements,  the  exercise  price  of  the 
Private Placement Warrants was reset from $5.10 per share to $2.81 per share. The Company recorded an increase in the liability for 
derivative instrument of $2,756 and a corresponding loss was recorded in other expense, net and included in the change in fair value of 
derivative liabilities. The Company determined the aggregate fair value of the warrants, based on Black-Scholes, to be $98,786 as of 
March 31, 2010. See Note 8 for a discussion of the fair value of the warrants and embedded conversion features as of the dates of 
issuance.  

In February 2010, as a result of the 2010 Amendment, the exercise price of the Debenture Warrants was decreased from 
$4.50 per share to $3.30 per share, pursuant to the terms of the Debentures, which resulted in an increase in the liability for derivative 
instruments  of  $231,093  and  a  corresponding  loss  was  recorded  in  other  expense,  net  due  to  the  change  in  fair  value  of  derivative 
liabilities. In addition, the conversion price of the Debentures was decreased from $4.50 per share to $3.00 per share which resulted in 
an  increase in  the number of  shares of  common  stock which  the  Debentures may be  converted  into,  an increase  in the  liability for 
derivative instrument of $1,376,043 and a corresponding loss was recorded in other expense, net and included in the change in fair 
value of derivative liabilities (see Note 8).  

   
  
  
    
  
  
  
  
   
  
    
  
  
    
  
  
  
  
    
  
  
  
   
  
    
  
   
  
    
  
  
  
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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

In February 2010, as a result of the 2010 Amendment and partial conversion of the Debentures, the Company reclassified a 
portion  of  the derivative  liability  related to  the  conversion feature  of  the Debentures of $1,653,299  to additional paid in  capital. In 
addition,  due  to  the  modification  of  the  terms  of  the  Debentures,  the  remaining  derivative  liabilities  for  the  embedded  conversion 
features and warrants of $9,009,329 was reclassified to additional paid-in capital as they no longer require derivative treatment (see 
Note 8).  

During the year ended March 31, 2010, the Company issued to various placement agents in lieu of cash fees an aggregate of 
20,000  warrants  to  purchase  shares  of  the  Company’s  common  stock  with  a  fair  value  of  $87,448.  The  exercise  prices  of  these 
warrants are equal to $3.30, as reset from $5.10 on February 25, 2010 pursuant to the anti-dilution provisions contained in the warrant 
agreements and an additional 10,909 warrant shares were issued for an aggregate total of 30,909 warrants. The Company determined 
the aggregate fair value of the issued warrants, based on Black-Scholes, to be $55,961 as of March 31, 2010. Since the exercise price 
of the warrants is subject to adjustment in the event the Company issues the next equity financing, the warrants are accounted for as a 
derivative liability.  

During the year ended March 31, 2010, the Company modified the terms of an aggregate of 54,676 warrants to purchase 
shares of the Company’s common stock which were previously issued to various placement agents in lieu of cash fees. On April 5, 
2009, in connection with the termination  of a consulting  agreement,  the  Company modified the terms of 54,676 warrants issued in 
October 2007  and  May 2008.  The  exercise  price  of  the  warrants  was  reduced  from  $8.40  per  share  to  $6.00  per  share  and  the 
expiration  date  was  extended  to  5 years  from  the  date  of  modification.  As  a  result  of  the  modification,  the  Company  recognized 
expense  of  $10,763  in  other  expense,  net  based  on  the  change  in  the  Black-Scholes  fair  value  before  and  after  modification.  On 
February 25, 2010, the exercise price of the warrants was reduced from $6.00 per share to $3.30 per share pursuant to the anti-dilution 
provisions contained in the warrant agreements and an additional 44,735 warrant shares were issued, for an aggregate total of 99,411 
warrant shares. The Company recorded an increase in the liability for derivative instrument of $5,225 and a corresponding loss was 
recorded in other expense, net and included in the change in fair value of derivative liabilities. The Company determined the aggregate 
fair  value  of  the  issued  warrants,  based  on  Black-Scholes,  to  be  $179,616  as  of  March 31,  2010.  Since  the  exercise  price  of  the 
warrants  is  subject  to  adjustment  in  the  event  the  Company  issues  the  next  equity  financing,  the  warrants  are  accounted  for  as  a 
derivative liability.  

Fiscal Year 2011 Activity  

During  the  year  ended  March 31,  2011,  it  was  determined  that  the  anti-dilution  provisions  contained  in  the  Private 
Placement Warrants issued  in connection with the Private  Placement Debentures were  no  longer afforded  treatment  as  a derivative 
liability due to the equity financing in February 2010, thus the Company reclassified the derivative liability of $128,276 to additional 
paid-in capital.  

During  the  year  ended  March 31,  2011,  the  Company  issued  an  aggregate  of  36,371  warrants  to  purchase  shares  of  the 
Company’s common stock pursuant to the anti-dilution provisions contained in the warrant agreements which were previously issued 
to various placement agents in lieu of cash fees. On August 20, 2010, in connection with the August 2010 private placement closing, 
the exercise price of the warrants was reduced from $3.30 per share to $3.20 per share and the Company issued an additional 4,073 
warrants.  On  February 4,  2011,  in  connection  with  the  February 2011  private  placement,  the  exercise  price  of  the  warrants  was 
reduced  from $3.20  per  share  to $2.81  per share  and the Company  issued an additional 18,657 warrants. On  February 14, 2011,  in 
connection with the February 2011 private placement, the exercise price of the warrants was reduced from $2.81 per share to $2.58 per 
share  and  the  Company  issued  an  additional  13,641  warrants.  Since  the  exercise  price  of  the  warrants  is  subject  to  additional 
adjustment in the event the Company issues dilutive equity securities, as described in the original warrant agreements, the warrants are 
accounted for as a derivative liability.  

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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

During the years ended March 31, 2011 and 2010, the Company recognized aggregate gains of $49,590 and $5,576,979, 
respectively,  due  to  the  change  in  fair  value  of  its  derivative  instruments.  See  Note  5  for  the  components  of  changes  in  derivative 
liabilities. The Company’s common stock purchase warrants do not trade in an active securities market, and as such, the Company 
estimated the fair value of these warrants using the Black-Scholes option pricing model using the following assumptions:  

Expected dividends  
Expected term (in years)  
Risk-free interest rate  
Expected volatility  

   March 31, 

   March 31, 

2011 
— 
3.01 – 4.22 

2010 
— 
3.50 – 5.00 

   0.64% – 1.79%    1.42% – 2.69% 
178% – 204% 

128% – 189%   

Historical volatility was computed using daily pricing observations for recent periods that correspond to the remaining term 
of the warrants, which had an original term of five years from the date of issuance. The expected life is based on the remaining term of 
the warrants. The risk-free interest rate is based on U.S. Treasury securities with a maturity corresponding to the remaining term of the 
warrants.  

The  Company  estimated  the  fair  value  of  the  embedded  conversion  features  related  to  its  convertible  debentures  using 

Black-Scholes using the following assumptions:  

Expected dividends  
Expected term (in years)  
Risk-free interest rate  
Expected volatility  

March 31, 
2010 
— 
0.09 – 2.43 
0.06% – 1.65%   
81% – 150%    

Historical volatility was computed using daily pricing observations for recent periods that correspond to the remaining life 
of  the  related  debentures.  The  expected  life  is  based  on  the  remaining  term  of  the  related  debentures.  The  risk-free  interest  rate  is 
based on U.S. Treasury securities with a maturity corresponding to the remaining term of the related debentures.  

Note 10. Stockholders’ Equity  

Common Stock  

The  Company’s  authorized  capital  consists  of  250,000,000  shares  of  common  stock,  $0.001  par  value  per  share.  On 
February 5,  2010,  the  Company  filed  a  Certificate  of  Amendment  to  Amended  and  Restated  Articles  of  Incorporation  with  the 
Secretary of State of the State  of Nevada to  effect a 10-to-1 reverse stock split  of the Company’s issued and outstanding shares of 
common  stock.  As  of  March 31,  2011  and  2010,  27,504,583  and  8,136,619  shares  of  common  stock  were  issued  and  outstanding, 
respectively.  

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Table of Contents  

Fiscal Year 2010 Activity  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

In May 2009, $713,000 of the October 2007 Debentures was converted by the note holders. Using the conversion rate of 

$5.10 per share per the terms of the Debenture, 139,804 shares of registered common stock were issued to the investors.  

On September 28, 2009, the Company issued 2,353 shares of common stock, in lieu of $12,000 in fees paid for services 

performed by Carpe DM, Inc., which were issued at a value of $5.10 per share.  

In July 2009, the Company engaged an agent to solicit the holders of certain warrants to exercise their rights to purchase 
shares of the Company’s common stock. Pursuant to the terms of the engagement, the Company agreed to pay the agent compensation 
of 5%  of  the gross  proceeds totaling $76,632, which is included  equity  and netted against  the gross  proceeds in the  accompanying 
consolidated balance sheet at March 31, 2010. In addition, the Company issued to the agent a warrant to purchase a number of shares 
of  the  Company’s  common  stock  equal  to  5%  of  the  number  of  shares  issued  in  the  exercise  of  the  warrants,  or  a  total  of  23,952 
warrants with a fair value of $98,256 or $4.10 per share. The warrant has an exercise price of $5.10 and will permit the agent or its 
designees  to  purchase  shares  of  common  stock  on  or  prior  to  October 1,  2014.  The  fair  value  of  warrants  has  been  recorded  as  an 
offset  to  additional  paid-in  capital  on  the  accompanying  consolidated  balance  sheets.  During  the  year  ended  March 31,  2010,  the 
Company  issued  479,033  shares  of  its  common  stock  for  gross  cash  proceeds  of  $1,437,100  from  the  exercise  of  warrants  which 
resulted from the solicitation.  

During July 2009, the Company entered into the July Agreement with the holders of the Company’s Debentures (see Note 
8).  Pursuant  to  the  terms  of  the  July  Agreement,  the  Holders  (i)  consented  to  the  Company’s  issuance  of  convertible  notes  and 
warrants in connection with the Bridge Financing of up to $1,500,000 which commenced in March 2009, and (ii) waived, as it relates 
to the Bridge Financing, a covenant contained in the Debentures not to incur any further indebtedness, except as otherwise permitted 
by  the  Debentures.  This  Bridge  Financing  is  more  particularly  described  in  Note  8  above  under  the  caption  “Private  Placement 
Debentures.” In addition, in connection with the July Agreement, the Company and Holders confirmed that (i) the exercise price of the 
warrants  issued to  the Holders  in connection  with  their  purchase  of  the  Debentures  had  been  reduced,  pursuant  to the  terms  of  the 
warrants, to $5.10 as a result of the Bridge Financing, and (ii) as a result of the foregoing decrease in the exercise price, pursuant to 
the terms of the warrants, the number of shares underlying the warrants held by Holders of the Debentures had been proportionally 
increased by 404,350 pursuant to the terms of the warrant agreements (see Note 8).  

In  August 2009,  the  Company  issued  warrants  to  purchase  600  shares  of  common  stock  in  lieu  of  payment  to  Gary  C. 
Cannon, who then served as Corporate Legal Counsel for the Company and as a member of the Advisory Board, to purchase shares of 
the Company’s common stock at an exercise price of $5.10 per share with a five year term. The exercise prices of these warrants are 
greater than or equal to the stock price of the Company’s shares as of the date of grant. The fair market value of the warrants based on 
Black-Scholes of $2,799 was recorded as consulting and compensation  expense  and included  in selling,  general  and  administrative 
expenses during the year ended March 31, 2010. In July 2009, Mr. Cannon was given a 30 day notice of his termination as general 
legal counsel and advisor to the Company. During November 2009, the Company issued 4,314 shares of common stock to Mr. Cannon 
in lieu of payment for services for a total expense of $22,000 which has been included in selling, general and administrative expenses.  

Effective  September 1,  2009,  in  connection  with  the  September  Amendment  with  the  holders  of  the  Debentures,  the 
exercise price of the Debenture Warrants was reduced to $4.50 per share which resulted in a proportionate increase in the number of 
shares that may be purchased upon the exercise of such warrants of 359,423 shares (see Note 8).  

In September 2009, $100,000 of the October 2007 Debentures was converted by the note holder. Using the conversion rate 

of $4.50 per share per the terms of the Debentures, 22,222 share of registered common stock were issued to the investor.  

On October 30, 2009, the Company issued 5,881 shares of common stock, in lieu of fees paid for services performed by the 

Board of Directors. These shares were issued at a value of $4.30 per share, for a total value of $25,288.  

During October and November 2009, the holders of the October 2007 Debentures converted $370,000 principal into 82,222 

shares of the Company’s common stock at a conversion price of $4.50 per share per the terms of the Debentures (See Note 8).  

During January, 2010, the holders of the October 2007 Debentures converted $200,000 principal into 44,444 shares of the 

Company’s common stock at a conversion price of $4.50 per share per the terms of the Debentures (see Note 8).  

On February 19, 2010, we entered into the 2010 Amendment with the holders of our Debentures (see Note 8). Pursuant to 
the 2010 Amendment, the holders each converted $1,357,215 in principal amount of the outstanding principal balance of such holder’s 
debenture in exchange for a number of shares of common stock determined by dividing such principal amount by the unit offering 
price.  Based  on  the  public  offering  price  of  $3.00  per  unit,  each  holder  received  a  total  of  452,405  shares  of  common  stock  upon 
conversion. The conversion price of the remaining outstanding balance of each debenture was reset to $3.00 based on the Company’s 
public offering price. As a result of the conversion of an aggregate of $2,714,430 outstanding principal, the Company reclassified a 
portion  of  the derivative liability related  to  the conversion  feature  of  the Debentures  of  $1,450,605 to  additional  paid-in  capital.  In 

addition, pursuant to the 2010 Amendment, certain anti-dilution provisions contained in the debentures and warrants held 
by the debenture holders were terminated along with the right to maintain a fully-diluted ownership of our common stock equal to 
34.5%,  which  resulted  in  the  reclassification  of  $9,009,329  of  derivative  liability  related  to  the  embedded  conversion  features  and 
warrants to additional paid-in capital. Pursuant to the terms of the 2010 Amendment, the exercise price of the warrants currently held 
by  the  debenture  holders  was  reset  to  equal  the  exercise  price  of  the  warrants  included  as  part  of  the  units  sold  in  the  Company’s 
public offering (110% of the unit offering price or $3.30 per share) and the exercise period was extended to January 1, 2015.  

On February 25, 2010 the Company completed a public offering of units consisting of 1,666,667 shares of the Company’s 
common stock and 1,666,667 warrants to purchase one share of the Company’s common stock for gross proceeds of $5,000,001 and 
net cash proceeds of approximately $3,742,097. Each unit consisting of one share, together with one warrant to purchase one share, 
was priced at $3.00. The warrants issued as part of the offering have an exercise price of $3.30 and a term of 5 years. In addition, the 
Company  issued  a  warrant  to  purchase  83,333  shares  of  the  Company’s  common  stock  to  the  underwriter’s  representative  at  an 
exercise  price of $3.75 with a 5 year term and have a  fair value of  $199,043 based on Black-Scholes. Pursuant to the offering, the 
Company issued to an investment banker warrants to purchase 17,500 shares of the Company’s common stock with a fair value of 
$41,939, which represented 7% of the warrants issued to the holders of the Company’s Debentures participating in the public offering, 
at an exercise price of $3.30 per share and a 5 year term.  

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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

During  the  year  ended  March 31,  2010,  the  Company  issued  to  the  purchasers  of  the  Private  Placement  Debentures 
warrants  to  purchase  an  aggregate  of  51,824  shares  of  common  stock  at  an  initial  exercise  price  of  $5.10.  In  February 2010, 
immediately  prior  to  the  Company’s  public  offering,  the  holders  of  the  Private  Placement  Debentures  converted  the  aggregate 
principal balance of $1,381,500 and accrued interest of $78,701 into 519,186 shares of the Company’s common stock at a conversion 
price of $2.81 in prepayment of all amounts due. As a result of the conversion of all outstanding amounts, the Company reclassified 
the derivative liability for the embedded conversion feature of $273,465 to additional paid-in capital. In addition, pursuant to the anti-
dilution provisions contained in the Private Placement Warrant agreements, the exercise price of the Private Placement Warrants was 
reset from $5.10 per share to $2.81 per share (see Notes 8 and 9).  

On March 23, 2010, the Company issued warrants to purchase 15,000 shares of the Company’s common stock with a fair 
value of $27,426 to an agent for continued shareholder support at an exercise price of $1.91 per share. The warrants were recorded in 
equity with a corresponding charge to general and administrative expense.  

During the year ended March 31, 2010, the Company issued 20,000 warrants to purchase shares of the Company’s common 
stock to various placement agents. The warrants were issued in April 2009 with a fair value of $87,448 and an exercise price of $5.10 
and were classified as derivative liabilities. The exercise price of these warrants was reset to $3.30 per share from $5.10 per share on 
February 25,  2010  pursuant  to  the  anti-dilution  provisions  contained  in  the  warrant  agreements,  and  an  additional  10,909  warrant 
shares were issued for an aggregate total of 30,909 warrants (see Note 9).  

During  the  year  ended  March 31,  2010,  the  Company  modified  the  terms  of  54,676  warrants  to  purchase  shares  of  the 
Company’s common stock which were previously issued to various placement agents and currently classified as derivative liabilities. 
In  April 2009,  the  exercise  price  of  the warrants  was  reduced  from  $8.40  per  share  to  $6.00  per  share  and  the  expiration  date  was 
extended to 5 years from the date of modification. On February 25, 2010, the exercise price of the warrants was reduced from $6.00 
per  share  to  $3.30  per  share  pursuant  to  the  anti-dilution  provisions  contained  in  the  warrant  agreements  and  an  additional  44,735 
warrant shares were issued, for an aggregate total of 99,411 warrant shares. See Note 9 for a discussion of the accounting impact.  

During the year ended March 31, 2010, the Company issued 4,719 shares of common stock upon the cashless exercise of a 
total of 11,640 warrants at an average exercise price of $2.80 per share and 11,034 shares of common stock upon the cashless exercise 
of a total of 11,900 options at an average exercise price of $0.40 per share.  

During  the  year  ended  March 31,  2010,  the  Company  issued  20,942  shares  of  common  stock  the  resale  of  which  was 
registered pursuant to Form S-8 in lieu of fees paid for services performed by consultants. On April 13, 2009 and June 11, 2009, the 
Company  filed  the  related  Forms  S-8  with  the  SEC.  These  shares  were  issued  at  a  value  of  $5.10  per  share  with  a  total  value  of 
$106,806 which has been included in selling, general and administrative expenses for the year ended March 31, 2010.  

During the year ended March 31, 2010, the Company converted interest payments due on the Debentures totaling $171,253 

into 42,814 shares of common stock using the conversion rate of $4.00 per share.  

During the year ended March 31, 2010, a total of 21,000 warrants and 190,553 stock options with a weighted average fair 

value of $3.53 per share were granted to employees and directors (see Note 11).  

During the year ended March 31, 2010, the Company issued 16,253 warrants with a fair value of $63,396 or $3.90 per share 

for commissions due in connection with the Company’s Private Placement Debentures (see Note 8).  

Fiscal Year 2011 Activity  

In April 2010, the Company issued 13,636 shares of unrestricted common stock in lieu of fees paid to various consultants 
for services incurred in fiscal year 2010 pursuant to the Company’s Form S-8 filed on April 27, 2010. These shares were issued at a 
value of $1.76 per share for a total cost of $23,999 which is included in accounts payable and accrued expenses and selling, general 
and administrative expense as of and for the year ended March 31, 2010 in the accompanying consolidated financial statements.  

In May 2010, the Company granted 40,000 warrants to a consultant to purchase shares of the Company’s common stock 
with an  exercise price  of  $1.89.  Of  the  40,000  warrants, 20,000 warrants  with  a  fair  value  of $36,030  vested upon  issuance  and  is 
included in selling, general and administrative expenses in the accompanying consolidated statements of operations. The remaining 
20,000 shares vest upon completion of certain key milestones (see Note 12).  

F-25  

   
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

During  August 2010,  the  Company  closed  its  first  round  of  a  private  placement  financing  to  institutional  and  accredited 
investors resulting in the issuance of units consisting of 4,699,550 shares of common stock and warrants to purchase 4,699,550 shares 
of common stock at an exercise price of $0.77 per share, for gross cash proceeds of $3,289,701 and net cash proceeds of $2,990,953. 
Each unit consisting of one share of common stock, together with one warrant to purchase one share of common stock, was priced at 
$0.70.  Certain  investors  that  had  invested  in  the  Company’s  public  offering  that  was  completed  on  February 25,  2010  were  issued 
additional warrants with the same terms to purchase an aggregate of 448,333 shares of common stock in connection with this private 
placement. The fair market value of the warrants issued to prior investors of $307,794 was based on Black-Scholes and recorded to 
additional paid-in capital and offset against the proceeds of the financing with no net effect on equity. In connection with the closing 
of  this  first  round  of  financing,  the  Company  paid  a  7%  fee  to  the  placement  agents  of  $230,279  and  issued  warrants  to  purchase 
657,940 shares of the Company’s common stock, at an exercise price of $0.77, which are immediately exercisable and have a term of 
five years. The fair  market value of the warrants issued to the placement agents of $449,938 was  based on Black-Scholes and was 
recorded  to  additional  paid-in  capital  and  offset  against  the  proceeds  of  the  financing  with  no  net  effect  on  equity.  The  Company 
incurred additional legal and accounting fees of $36,207 in connection with the first round of financing.  

During September 2010, the Company received a $29,067 credit for financing fees which were reclassed to additional paid-

in capital during the year ended March 31, 2010, and offset against the proceeds related to the February 2010 public offering.  

On October 14, 2010, the Company closed on its second round of a private placement financing of its securities to certain 
institutional and accredited investors that commenced in August 2010. In connection with the second closing of the private placement 
financing, the Company received aggregate gross proceeds of $583,001 and net cash proceeds of $416,726. The investors purchased 
an aggregate of 832,868 units priced at $0.70 per unit, with each unit consisting of one share of common stock and one warrant to 
purchase one share of common stock at an exercise price of $0.77 per share. The warrants are immediately exercisable and have a 
term of five years. In connection with this second round of financing, the Company paid a 7% fee to the placement agents of $40,811 
and issued a warrant to purchase 116,602 shares of Common Stock at an exercise price of $0.77 per share, which are immediately 
exercisable and have a term of five years. The fair market value of the warrants issued to the placement agents of $85,719 was based 
on Black-Scholes and was recorded to additional paid-in capital and offset against the proceeds of the financing with no net effect on 
equity. The Company incurred additional legal and accounting fees of $122,964 in connection with the second round of financing.  

Pursuant to the Registration Rights Agreement, on October 19, 2010, the Company filed a registration statement on Form 
S-1 with the Securities and Exchange Commission (“SEC”) registering the resale of the 12,287,711 shares of common stock issued to 
the  investors  that  participated  in  both  the  first  closing  of  the  private  placement  during  August 2010  and  the  second  closing  of  the 
private placement during October 2010, and the shares of common stock underlying the warrants issued to the investors and placement 
agents in both closings. The registration statement was declared effective by the SEC on December 29, 2010.  

During January 2011, the holders of the October 2007 Debentures converted $200,000 principal into 66,666 shares of the 

Company’s common stock at a conversion price of $3.00 per share per the terms of the Debentures (see Note 8).  

On February 4, 2011, the Company consummated the first closing of a private placement to accredited investors resulting in 
the issuance of units consisting of 6,335,318 shares of common stock and warrants to purchase 6,335,318 shares of common stock at 
an exercise price of $0.77, for gross cash proceeds of $4,434,722. On February 14, 2011, the Company completed the second closing 
of  this  same  private  placement  resulting  in  the  issuance  of  units  consisting  of  7,026,771  shares  of  common  stock  and  warrants  to 
purchase 7,026,771 shares of common stock at an exercise price of $0.77, for gross cash proceeds of $4,918,740. In both closings, 
each unit consisting of one share, together with one warrant to purchase one share, was priced at $0.70 for aggregate gross proceeds of 
$9,353,462. Aggregate net proceeds which reflect placement agent fees, legal and accounting fees were $8,041,880. In addition, as 
part of the compensation to the selling agents, warrants to purchase 2,393,826 shares of common stock were issued to the agents. The 
warrants issued to the investors and selling agents are immediately exercisable and have a term of five years. The fair market value of 
the warrants issued to the placement agents of $2,153,397 was based on Black-Scholes and was recorded to additional paid-in capital 
and  offset  against  the  proceeds  of  the  financing  with  no  net  effect  on  equity.  The  Company  was  obligated  to  file  a  registration 
statement with the SEC registering the resale of the shares of common stock issued to the investors and the shares of common stock 
underlying the warrants issued to the investors within ninety (90) days following the close of the transaction.  

On March 4, 2011, the Company granted a warrant to a related party (see Note 7) to purchase 200,000 shares of common 
stock  with  an  exercise  price  of  $0.77  valued  at  $302,769  as  calculated  using  Black  Scholes.  The  assumptions  used  under  Black-
Scholes included: a risk free rate of 2.17%; volatility of 179%; a term of 5.01 years; and no annual dividend rate. The warrant was 
issued pursuant to a one year consulting agreement and vested upon issuance. The Company recorded $277,538 as an other current 
asset and recognized $25,231 in selling, general and administrative expense for the year ended March 31, 2011 in the accompanying 
consolidated financial statements.  

Pursuant to the Registration Rights Agreement, on April 22, 2011, the Company filed a registration statement on Form S-1 
with  the  SEC  registering  the  resale  of  40,943,178  shares  of  common  stock  issued  to  the  investors  that  participated  in  the 
February 2011 private placement, the private placement which occurred during August 2010 and October 2010, the shares of common 
stock underlying the warrants issued to the investors and placement agents in both private placements and the underlying shares of 

common  stock  which  will  be  issued  upon  exercise  of  the  publicly  traded  warrants  that  were  issued  as  part of  the  public 

offering of units the occurred in February 2010.  

F-26  

   
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

During the year ended March 31, 2011, the Company issued 36,371 warrants to purchase shares of the Company’s common 
stock to various placement agents pursuant to the anti-dilution provisions contained in their original warrant agreements (see Note 9). 
The  anti-dilution  provisions  were  triggered  as  a  result  of  the  Company’s  private  placements  which  occurred  in  August 2010  and 
February 2011. An aggregate of 166,691 placement agent warrants were classified as derivative liabilities at March 31, 2011, and had 
a fair value of $156,497 and an exercise price of $2.58 (reduced from an exercise price of $3.30 at March 31, 2010).  

During  the  year  ended  March 31,  2011,  the  Company  reclassified  $128,276  of  derivative  liability  related  to  the  Private 

Placement Warrants to additional paid-in capital (see Note 9).  

During the year ended March 31, 2011, the Company issued 274,500 shares of common stock upon the exercise of warrants 
at an exercise price of $0.77 per share and 4,594 shares of common stock upon the exercise of options at an exercise price of $0.40 per 
share.  

During the year ended March 31, 2011, the Company issued 114,061 shares of common stock upon the cashless exercise of 

a total of 209,525 warrants at an exercise price of $0.77 per share.  

During the year ended March 31, 2011, stock options to purchase a total of 1,296,832 shares of the Company’s common 
stock with a weighted average value of $0.69 per share were granted to employees and directors. Included in this amount were stock 
options to purchase 362,232 shares of the Company’s common stock issued to the Company’s Chief Executive Officer in lieu of a 
cash bonus for fiscal year 2010. As of and for the year ended March 31, 2010, this bonus was included in accrued compensation and 
related  expenses  and  selling,  general  and  administrative  expenses  in  the  accompanying  consolidated  financial  statements  (see  Note 
11).  

Warrants Outstanding:  

A  summary  of  the  Company’s  warrant  activity  (other  than  those  warrants  issued  to  the  Company’s  employees,  officers, 
directors and related consultants presented in the Stock Compensation Plan Section below) and related information during the 2011 
fiscal year follows:  

Outstanding at April 1, 2010  
Granted  
Exercised  
Forfeited  
Expired  

Outstanding at March 31, 2011  

Exercisable  

   Number of Shares     
5,227,677     
22,787,582     
(388,561 )   
(95,464 )   
(21,420 )   

Weighted- 
Average 
Exercise Price     
3.43     
$ 
0.78     
$ 
0.77     
$ 
0.77     
$ 
6.99     
$ 

Remaining 
Contractual 
Life (Years) 

Aggregate 
Intrinsic Value   
$   

279,953   

27,509,814     

$ 

27,489,814     

$ 

1.27     

1.27     

4.55     

$ 

14,003,125   

4.54     

$ 

14,003,125   

At March 31, 2010 the number of unvested warrants was 20,000. The following summary information reflects outstanding 

warrants to purchase shares of the Company’s common stock as of March 31, 2011 and other related details:  

Year of Grant 
(as of March 31) 

2008  
2009  
2010  
2011  

Warrants Outstanding 

     Remaining   
     Contractual   
   Exercise Price    Number Outstanding      Life (Years)   

   $1.50 – $15.00   
   $2.81 – $8.50   
   $1.91 – $5.10   
   $0.77 – $2.74   

1,777,153     
659,881     
2,769,223     
22,303,557     
27,509,814     

3.69   
3.60   
3.81   
4.73   

F-27  

   
  
  
     
    
    
    
    
    
    
  
  
  
     
    
    
    
    
  
  
  
     
    
    
    
  
  
    
  
  
    
    
  
  
  
    
    
    
  
  
  
  
      
  
  
  
  
      
  
    
  
  
  
      
  
    
    
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
    
    
    
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
    
    
    
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
     
    
    
  
  
  
  
  
  
  
  
     
  
  
  
     
   
  
  
  
  
      
  
    
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
   
  
  
  
  
  
    
    
  
  
  
  
  
  
  
    
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 11. Stock Compensation Plan  

The  Company  accounts  for  share-based  payments  to  employees  and  directors  in  accordance  with  share-based  payment 
accounting literature which requires all share-based payments to employees and directors, including grants of employee stock options 
and warrants, to be recognized in the consolidated financial statements based upon their fair values. The Company uses Black-Scholes 
to estimate the grant-date fair value of share-based awards. Fair value is determined at the date of grant. The consolidated financial 
statement  effect  of  forfeitures  is  estimated  at  the  time  of  grant  and  revised,  if  necessary,  if  the  actual  effect  differs  from  those 
estimates. The estimated average forfeiture rate for the years ended March 31, 2011 and 2010 was zero, as the Company has not had a 
significant history of forfeitures and does not expect forfeitures in the future.  

Cash flows resulting from the tax benefits resulting from tax deductions in excess of the compensation cost recognized for 
those options or warrants to be classified as financing cash flows. Due to the Company’s loss position, there were no such tax benefits 
during the years ended March 31, 2011 and 2010.  

Plan Descriptions  

The  Company  maintains  two  stock  option  plans,  the  2002  Stock  Incentive  Plan  (the  “2002  Plan”)  and  the  2009  Stock 
Incentive Plan (the “2009 Plan”). The 2002 Plan provides for grants of incentive stock options and nonqualified options to employees, 
directors and consultants of the Company to purchase the Company’s shares at the fair value, as determined by management and the 
board of directors, of such shares on the grant date. The options are subject to various vesting conditions and generally vest over a 
three-year  period  beginning  on  the  grant  date  and  have  seven  to  ten-year  term.  The  2002  Plan  also  provides  for  the  granting  of 
restricted shares of common stock subject to vesting requirements. The Company is authorized to issue up to 500,000 shares under this 
plan and has 318,136 shares available for future issuances as of March 31, 2011.  

On  October 9,  2009,  the  Company’s  stockholders  approved  and  adopted  the  2009  Plan,  which  had  previously  been 
approved by the Company’s Board of Directors on August 31, 2009. The 2009 Plan provides for the grant of incentive stock options, 
nonqualified  stock  options,  restricted  stock  rights,  restricted  stock,  performance  share  units,  performance  shares,  performance  cash 
awards,  stock  appreciation  rights,  and  stock  grant  awards  (collectively,  “Awards”)  to  employees,  officers,  non-employee  directors, 
consultants  and  independent  contractors  of  the  Company.  The  2009  Plan  also  permits  the  grant  of  awards  that  qualify  for  the 
“performance-based compensation” exception to the $1,000,000 limitation on the deduction of compensation imposed by Section 162
(m) of the  Internal Revenue Code. A total  of  1,200,000 shares of the Company’s common stock  are authorized for  the granting of 
Awards under the 2009 Plan. The number of shares available for future awards, as well as the terms of outstanding awards, is subject 
to adjustment as provided in the 2009 Plan for stock splits, stock dividends, recapitalizations and other similar events. Awards may be 
granted under the 2009 Plan until October 9, 2019 or until all shares available for awards under the 2009 Plan have been purchased or 
acquired.  The  Company  is  authorized  to  issue  up  to  1,200,000  shares  under  this  plan  and  has  209,724  shares  available  for  future 
issuances as of March 31, 2011.  

In  addition  to  the  stock  options  issued  pursuant  to  the  Company’s  two  stock  option  plans,  the  Company  has  granted 
warrants  to  employees,  officers,  non-employee  directors,  consultants  and  independent  contractors.  The  warrants  are  generally  not 
subject to vesting requirements and have ten-year terms.  

As of March 31, 2011, a total of 136,401 and 976,640 shares of common stock were reserved for issuance under the 2002 
and  2009  Stock  Plans,  respectively,  and  a  total  of  312,855  shares  of  common  stock  were  reserved  for  issuance  upon  exercise  of 
outstanding warrants. A summary of the Company’s employee and director stock option and warrant activity and related information 
during the 2011 fiscal year follows:  

   Number of     Weighted- Average     

Remaining 

     Aggregate 

Shares 

     Exercise Price 

     Contractual Life      Intrinsic Value   

Outstanding at April 1, 2010  
Granted  
Exercised  
Canceled  

   555,203     $ 
   1,296,832     $ 
(4,594 )   $ 
   (421,545 )   $ 

Outstanding and expected to vest at March 31, 2011  
Exercisable at March 31, 2011  

   1,425,896     $ 
   993,396     $ 

6.22           
0.72           
0.40           
1.11           

2.75        
3.55        

     $   

4,594   

7.75      $ 
7.15      $ 

709,703   
418,573   

F-28  

   
  
  
    
         
          
          
  
  
  
  
  
  
  
  
          
  
  
  
       
  
          
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
    
         
          
          
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

The  following  summary  information  reflects  stock  options  and  warrants  outstanding,  vesting  and  related  details  as  of 

March 31, 2011:  

Year of Grant 
(as of March 31) 
2003  
2004  
2005  
2007  
2008  
2009  
2010  
2011  

Stock Options and Warrants Outstanding 

Remaining      
     Contractual     
Number 
   Exercise Price    Outstanding      Life (Years)     
2.59     
3.26     
2.30     
5.45     
6.77     
7.71     
6.07     
8.53     

$10.00 
6.00 
0.40 – 6.00 
2.80 – 10.00    
7.50 – 10.80    
5.10 – 10.50    
4.30 – 8.30 
0.66-2.00 

5,000     
20,000     
22,201     
111,335     
88,780     
91,740     
107,008     
979,832     
   1,425,896     

Vested and   
Exercisable   
5,000   
20,000   
22,201   
111,335   
88,780   
91,740   
84,008   
570,332   
993,396   

The Company uses Black-Scholes to recognize the value of stock-based compensation expense for all share-based payment 
awards. Determining the appropriate fair-value model and calculating the fair value of stock-based awards at the grant date requires 
considerable judgment, including estimating stock price volatility, expected option life and forfeiture rates. The Company develops 
estimates  based  on  historical  data  and  market  information,  which  can  change  significantly  over  time.  Black-Scholes  requires  the 
Company to make several key judgments including:  

• 

• 

• 

• 

• 

  The expected option term reflects the application of the simplified method set out in SAB No. 107 Share-Based Payment 
(SAB  107),  which  was  issued  in  March 2005.  In  December 2007,  the  SEC  released  Staff  Accounting  Bulletin  No. 110 
(SAB 110), which extends the use of the “simplified” method, under certain circumstances, in developing an estimate of 
expected term of “plain vanilla” share options. Accordingly, the Company has utilized the average of the contractual term 
of the options and the weighted average vesting period for all options and warrants to calculate the expected option term.  

  Estimated volatility also reflects the historical volatility pattern of the Company’s share price.  

  The dividend yield is based on the Company’s historical pattern of dividends as well as expected dividend patterns.  

  The  risk-free  rate  is  based  on  the  implied  yield  of  U.S.  Treasury  notes  as  of  the  grant  date  with  a  remaining  term 

approximately equal to the expected term.  

  Estimated forfeiture rate of 0% per year is based on the Company’s historical forfeiture activity of unvested stock options. 
The  Company  used  the  following  assumptions  for  stock  options  and  warrants  granted  during  the  years  ended  March 31, 
2011 and 2010:  

Risk-free interest rate  
Expected volatility  
Expected life (in years)  
Expected dividend yield  

Years Ended March 31, 
2010 
2011 

   0.77% – 3.32%    1.38% – 3.04% 
179% – 197% 
3.50 – 6.02 
N/A 

142% – 179%   
3.50 – 6.48 
N/A 

F-29  

   
  
  
  
  
    
    
    
    
    
  
  
  
  
  
  
  
  
  
  
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
    
  
  
  
   
  
  
  
  
      
  
    
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

For the years ended March 31, 2011 and 2010, the weighted-average fair value of the Company’s stock option and warrant 

grants are as follows:  

Grant Year 

March 31, 2011  
March 31, 2010  

     Weighted 
Average 

     Fair Value of   
     Options and   
     Warrants 

Granted 

   1,296,832     
211,553     

$ 
$ 

0.69   
3.53   

There were no warrants and 1,296,832 stock options granted to employees and directors during the year ended March 31, 
2011, and 21,000 warrants and 190,553 stock options for an aggregate of 211,553 shares granted to employees and directors during 
the year ended March 31, 2010. In connection with the warrants and options granted and the vesting of prior warrants issued, during 
the years ended March 31, 2011 and 2010, the Company recorded total charges of $396,696 and $559,561, respectively, which have 
been  included  in  selling,  general  and  administrative  expenses  in  the  accompanying  consolidated  statements  of  operations.  The 
Company issues new shares from its authorized shares upon exercise of warrants or options.  

As of March 31, 2011, there was $286,821 of total unrecognized compensation cost, related to non-vested stock options and 

warrants, which is expected to be recognized over a remaining weighted average vesting period of 1.83 years.  

The aggregate intrinsic value of stock options and warrants exercised during the years ended March 31, 2011 and 2010 was 

$4,594 and $79,964, respectively.  

Note 12. Equity Instruments Issued to Non-Employees for Acquiring Goods or Services  

Issuances  of  the  Company’s  common  stock  for  acquiring  goods  or  services  are  measured  at  the  fair  value  of  the 
consideration  received  or  the  fair value  of  the equity  instruments issued, whichever  is  more reliably measurable. The measurement 
date for the fair value of the equity instruments issued to consultants or vendors is determined at the earlier of (I) the date at which a 
commitment for performance to earn the equity instruments is reached (a “performance commitment” which would include a penalty 
considered to be of a magnitude that is a sufficiently large disincentive for nonperformance) or (ii) the date at which performance is 
complete. When it is appropriate for the Company to recognize the cost of a transaction during financial reporting periods prior to the 
measurement date, for purposes of recognition of costs during those periods the equity instrument is measured at the then-current fair 
values at each of those interim financial reporting dates.  

On May 11, 2010, the Company granted an aggregate of 40,000 warrants to purchase shares of the Company’s common 
stock at an exercise price of $1.89 to a consultant for services to be rendered through March 31, 2011 or until the related deliverables 
are met. Of the total warrants, 20,000 warrants vested upon issuance with a fair value of $36,090; the assumptions used under Black-
Scholes included: a risk free rate of 2.26%, volatility of 177%, an expected exercise term of 5.0 years and no annual dividend rate. The 
remaining 20,000 warrants will vest based upon attainment of certain deliverables and are valued accordingly at each interim reporting 
date  until  the  deliverables  are  completed.  The  Company  recognized  an  aggregate  of  $55,693  in  selling,  general  and  administrative 
expense related to these warrants for the year ended March 31, 2011 in the accompanying consolidated statements of operations.  

On March 4, 2011, the Company granted a warrant to a related party to purchase 200,000 shares of common stock with an 
exercise  price  of  $0.77  valued  at  $302,769  as  calculated  using  the  Black  Scholes  option  pricing  model.  The  warrant  was  issued 
pursuant to a one year consulting agreement and vested upon issuance. The assumptions used under Black-Scholes included: a risk 
free rate of 2.17%, volatility of 179%, a term of 5.01 years and no annual dividend rate. The Company recorded $277,538 as an other 
current  asset  and  recognized  $25,231  in  selling,  general  and  administrative  expense  for  the  year  ended  March 31,  2011  in  the 
accompanying consolidated financial statements.  

F-30  

   
  
  
    
    
    
  
  
  
    
  
  
  
    
    
  
  
  
    
  
  
    
  
  
   
  
    
    
    
  
  
  
  
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 13. Commitments and Contingencies  

Lease Commitments  

On July 2, 2007, the Company entered into a lease agreement with Viking Investors — Barents Sea, LLC (Lessor) for a 
building with approximately 11,881 square feet of manufacturing and office space located at 20382 Barents Sea Circle, Lake Forest, 
CA, 92630. The lease agreement is for a period of two years with renewal options for three, one-year periods, beginning September 1, 
2007. The lease required base lease payments of approximately $10,000 per month plus operating expenses. In connection with the 
lease agreement, the Company issued to the lessor a warrant to purchase 1,000 shares of common stock at an exercise price of $15.50 
per share for a period of two years, valued at $15,486 as calculated using the Black Scholes option pricing model. The assumptions 
used under Black-Scholes included: a risk free rate of 4.75%; volatility of 293%; an expected exercise term of 5 years; and no annual 
dividend rate. The Company capitalized and amortized the value of the warrant over the life of the lease and recorded the unamortized 
value of the warrant in other assets. For the years ended March 31, 2011 and 2010, the Company recognized warrant amortization of 
$0  and  $2,970,  respectively.  As  of  March 31,  2010  the  fair  value  of  the  warrant  was  fully  amortized.  On  August 24,  2009,  the 
Company entered into the second amendment to the lease for its manufacturing and office space. The amendment extended the lease 
for twelve months from the end of the existing lease term with a right to cancel the lease with a minimum of 120 day written notice at 
anytime as of November 30, 2009. In June 2010, Company entered into the third amendment to the lease for its manufacturing and 
office space. The amendment extended the lease for sixty months commencing July 1, 2010, with a right to cancel the lease with a 
minimum of 120 day written notice at anytime as of December 31, 2012, and adjusted the base lease payments to a range over the life 
of the agreement of $7,010 per month to $8,911 per month plus operating expenses.  

On April 11, 2011, the Company entered into an office service agreement with Regis Management Group, LLC (Lessor) 
for six (6) executive offices located at 402 West Broadway, San Diego, CA 92101. The office service agreement is for a six-month 
period ending October 31, 2011 and is subject to automatic renewal unless terminated with 90 days prior notice. The office service 
agreements require aggregate base lease payments of approximately $9,250 per month.  

Total rental expense was $170,358 and $144,728 for the years ended March 31, 2011 and 2010, respectively.  

Future annual minimum payments under operating leases are as follows:  

Years Ending March 31:  
2012  
2013  
2014  
2015  
2016  

Consulting and Engineering Services  

$ 

156,979   
96,153   
99,084   
104,793   
26,733   

$ 

483,742   

Effective  November 1,  2010,  the  Company  entered  into  a  Second  Amendment  to  Master  Consulting  and  Engineering 
Services Agreement (the “Second Amendment”) with KLATU Networks, LLC (“KLATU”), which amended the Master Consulting 
and  Engineering  Services  Agreement  between  the  parties  dated  as  of  October 9,  2007  (the  “Agreement”),  as  amended  by  the  First 
Amendment to Master Consulting and Engineering Services Agreement between the parties dated as of April 23, 2009. The parties 
entered into the Second Amendment to clarify their mutual intent and understanding that all license rights granted to the Company 
under the Agreement, as amended, shall survive any termination or expiration of the Agreement. In addition, in recognition that the 
Company has paid KLATU less than the market rate for comparable services, the Second Amendment provides that if the Company 
terminates  the  Agreement  without  cause,  which  the  Company  has  no  intention  of  doing,  or  liquidates,  KLATU  shall  be  entitled  to 
receive additional consideration for its services provided from the commencement of the Agreement through such date of termination, 
which additional compensation shall not be less than $2 million plus two times the “cost of work” (as defined in the Agreement). Any 
such additional compensation would be payable in three equal installments within 12 months following the date the amount of such 
additional compensation is determined.  

The  Master  Consulting  and  Engineering  Services  Agreement  dated  October 9,  2007,  as  amended  on  April 23,  2009  and 
November 1,  2010,  between  CryoPort,  Inc.  and  KLATU  Networks,  LLC  provides  a  framework  for  KLATU  to  provide  services  to 
CryoPort. The agreement provides for one year terms ending on December 31 of each year, but it automatically renews for one year 
periods unless otherwise terminated. CryoPort can terminate the agreement upon 30 days notice. If CryoPort terminates the agreement, 
it  has  to  pay  KLATU  a  termination  fee  that  will  not  be  less  than  $2,000,000  plus  two  times  the  cost  of  work  (as  defined  in  the 
agreement) performed by KLATU under the agreement.  

  
  
    
  
  
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
   
  
    
  
   
  
    
  
  
  
Litigation  

The Company may become a party to product litigation in the normal course of business. The Company accrues for open 
claims based on its historical experience and available insurance coverage. In the opinion of management, there are no legal matters 
involving the Company that would have a material adverse effect upon the Company’s financial condition or results of operations.  

Indemnities and Guarantees  

The  Company  has  made  certain  indemnities  and  guarantees,  under  which  it  may  be  required  to  make  payments  to  a 
guaranteed or indemnified party, in relation to certain actions or transactions. The guarantees and indemnities do not provide for any 
limitation of the  maximum potential future  payments  the  Company could  be obligated  to make. Historically, the  Company has  not 
been obligated nor incurred any payments for these obligations and, therefore, no liabilities have been recorded for these indemnities 
and guarantees in the accompanying consolidated balance sheets.  

The  Company  indemnifies  its  directors,  officers,  employees  and  agents,  as  permitted  under  the  laws  of  the  States  of 
California and Nevada. In connection with its facility lease, the Company has indemnified its lessor for certain claims arising from the 
use of the facility. The duration of the guarantees and indemnities varies, and is generally tied to the life of the agreement.  

In connection with the Company’s agreement with FedEx pursuant to which the Company leases to FedEx its cryogenic 
shippers,  the  Company  has  agreed  to  indemnify  and  hold  harmless  FedEx,  its  directors,  officers,  employees  and  agents  from  and 
against  any  and  all  claims,  demands,  causes  of  action,  losses,  damages,  judgments,  injuries  and  liabilities,  including  payment  of 
attorney’s  fees.  In  addition,  the  Company  has  agreed  to  indemnify,  defend  and  hold  harmless  FedEx,  its  Affiliates  (including  the 
corporate patent company), directors, officers, employees and agents from and against any and all Claims by third parties based on an 
allegation that the use of the Company’s shippers infringes on any United States or foreign intellectual property right of such third 
parties, including any potential royalty payments and other costs and damages, reasonable attorneys’ fees and out-of-pocket expenses 
reasonably incurred by FedEx. The duration of these indemnities survive the termination or expiration of the agreement.  

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Note 14. Income Taxes  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Significant components of the Company’s deferred tax assets as of March 31, 2011 and 2010 are shown below:  

Deferred tax asset:  

Net operating loss carryforward  
Research credits  
Expenses recognized for granting of options and warrants  
Accrued expenses and reserves  
Valuation allowance  

2011 

2010 

$  8,661,000     
28,000     
927,000     
41,000     
   (9,657,000 )   
—    
$ 

$  10,938,000   
24,000   
800,000   
104,000   
  (11,866,000 ) 
—  
$ 

Based on the weight of available evidence, the Company’s management has determined that it is more likely than not that 
the  net  deferred  tax  assets  will  not  be  realized.  Therefore,  the  Company  has  recorded  a  full  valuation  allowance  against  the  net 
deferred tax assets. The Company’s income tax provision consists of state minimum taxes.  

The  income  tax  provision  differs  from  that  computed  using  the  federal  statutory  rate  applied  to  income  before  taxes  as 

follows:  

Computed tax benefit at federal statutory rate  
State tax, net of federal benefit  
Warrant MTM Adjustment  
Permanent items and other  
Valuation allowance  

2011 
$  (2,091,000 )   
(307,000 )   
(17,000 )   
   4,625,600     
   (2,209,000 )   
1,600     
$ 

2010 
$  (1,920,000 ) 
(645,000 ) 
—  
   (3,226,400 ) 
   5,793,000   
1,600   
$ 

At March 31, 2011, the Company has federal and state net operating loss carryforwards of approximately $21,743,000 and 
$21,706,000 which will begin to expire in 2020 and 2014, respectively, unless previously utilized. At March 31, 2011, the Company 
has  federal  and  California  research  and  development  tax  credits  of  approximately  $17,000  and  $16,000,  respectively.  The  federal 
research tax credit begins to expire in 2026 unless previously utilized and the California research tax credit has no expiration date.  

Utilization of the net operating loss and research and development carryforwards might be subject to a substantial annual 
limitation due to ownership change limitations that may have occurred or that could occur in the future, as required by Section 382 of 
the  Internal  Revenue  Code  of  1986,  as  amended  (the  “Code”),  as  well  as  similar  state  and  foreign  provisions.  These  ownership 
changes may limit the amount of NOL and R&D credit carryforwards that can be utilized annually to offset future taxable income and 
tax,  respectively.  In  general,  an  “ownership  change”  as  defined  by  Section 382  of  the  Code  results  from  a  transaction  or  series  of 
transactions over a three-year period resulting in an ownership change of more than 50 percentage points of the outstanding stock of a 
company  by  certain  stockholders  or  public  groups.  Since  the  Company’s  formation,  the  Company  has  raised  capital  through  the 
issuance  of  capital  stock  on  several  occasions  which,  combined  with  the  purchasing  stockholders’  subsequent  disposition  of  those 
shares,  may  have  resulted  in  such  an  ownership  change,  or  could  result  in  an  ownership  change  in  the  future  upon  subsequent 
disposition.  

The  Company  has  not  completed  a  study  to  assess  whether  an  ownership  change  has  occurred.  If  the  Company  has 
experienced an ownership change, utilization of the NOL or R&D credit carryforwards would be subject to an annual limitation under 
Section 382  of  the  Code,  which  is  determined  by  first  multiplying  the  value  of  the  Company’s  stock  at  the  time  of  the  ownership 
change by the applicable long-term, tax-exempt rate, and then could be subject to additional adjustments, as required. Any limitation 
may result in expiration of a portion of the NOL or R&D credit carryforwards before utilization. Further, until a study is completed 
and any limitation is known, no amounts are being considered as an uncertain tax position or disclosed as an unrecognized tax benefit. 
Due  to  the  existence  of  the  valuation  allowance,  future  changes  in  the  Company’s  unrecognized  tax  benefits  will  not  impact  its 
effective tax rate. Any carryforwards that will expire prior to utilization as a result of such limitations will be removed from deferred 
tax assets with a corresponding reduction of the valuation allowance.  

FASB  ASC  Topic  740,  Income  Taxes  ,  which  clarifies  the  accounting  for  uncertainty  in  income  taxes  recognized  in  the 
financial statements, provides that a tax benefit from an uncertain tax position may be recognized when it is more likely than not that 
the  position  will  be  sustained  upon  examination,  including  resolutions  of  any  related  appeals  or  litigation  processes,  based  on  the 
technical  merits.  Income  tax  positions  must  meet  a  more  likely  than  not  recognition  threshold.  The  Company  did  not  record  any 
unrecognized  tax  benefits  upon  adoption  of  Accounting  for  Uncertainty  in  Income  Taxes.  The  Company’s  policy  is  to  recognize 
interest and penalties that would be assessed in relation to the settlement value of unrecognized tax benefits as a component of income 
tax expense.  

  
  
    
    
    
  
  
  
    
  
  
    
    
    
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
  
  
  
  
  
  
  
  
    
    
    
  
  
  
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
   
  
    
  
  
  
  
  
  
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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

The Company does not have any unrecognized tax benefits that will significantly decrease or increase within 12 months of 

March 31, 2011. The Company is subject taxation in the US and the state of California.  

As  of  March 31,  2011,  the  Company  is  no  longer  subject  to  U.S.  federal  examinations  for  years  before  2007  and  for 
California franchise and income tax examinations before 2006. However, to the extent allowed by law, the taxing authorities may have 
the  right to  examine  prior  periods  where net  operating  losses  were  generated  and  carried  forward,  and  make  adjustments  up  to  the 
amount  of  the  net  operating  loss  carry  forward  amount.  The  Company  is  not  currently  under  examination  by  U.S.  federal  or  state 
jurisdictions.  

Note 15. Quarterly Results of Operations (unaudited)  

The following table sets forth a summary of our unaudited quarterly operating results for each of the last eight quarters in 
the period ended March 31, 2011. This data has been derived from our unaudited consolidated interim financial statements which, in 
our opinion, have been prepared on substantially the same basis as the audited financial statements contained elsewhere in this report 
and include all normal recurring adjustments necessary for a fair presentation of the financial information for the periods presented. 
These unaudited quarterly results should be read in conjunction with our financial statements and notes thereto included elsewhere in 
this report. The operating results in any quarter are not necessarily indicative of the results that may be expected for any future period 
(in thousands except earnings per share).  

   Mar. 31,      Dec. 31,      Sept. 30,      June 30,      Mar. 31,      Dec. 31,      Sept. 30,      June 30,   

2011 

2010      

2010 

2010 

2010 

(Unaudited) 

2009      

2009 

2009 

Quarter Ended 

Revenues:  

   $ 

100      $ 

100      $ 

124      $ 

152      $ 

75      $ 

21      $ 

8      $ 

14   

Cost of revenues  

274     

257     

378     

395     

259     

133     

177     

149   

Gross loss  

(174 )   

(157 )   

(254 )   

(243 )   

(184 )   

(112 )   

(169 )   

(135 ) 

Research and 

development  
Selling, general and 
administrative  

107     

105     

115     

122     

15     

89     

93     

   1,182     

   1,081     

   1,114     

943     

   1,114     

690     

779     

Total operating expenses     

   1,289     

   1,186     

   1,229     

   1,065     

   1,129     

779     

872     

88   

729   

817   

Loss from operations  
Other income (expense), 

net  

Income (loss) before 
income taxes  

   (1,463 )   

   (1,343 )   

   (1,483 )   

   (1,308 )   

   (1,313 )   

(891 )   

   (1,041 )   

(952 ) 

(394 )   

(114 )   

(27 )   

(19 )   

747     

   3,342     

   (6,144 )   

602   

   (1,857 )   

   (1,457 )   

   (1,510 )   

   (1,327 )   

(566 )   

   2,451     

   (7,185 )   

(350 ) 

Income taxes  

—    

   —    

—    

2     

—    

   —    

2     

—  

Net income (loss)  

   $  (1,857 )    $ (1,457 )    $  (1,510 )    $  (1,329 )    $ 

(566 )    $  2,451      $  (7,187 )    $ 

(350 ) 

Net income (loss) per 
common share:  

Basic  
Weighted average 
common shares 
outstanding:  

Basic  

Diluted  

(0.09 )   

(0.11 )   

(0.15 )   

(0.16 )   

(0.09 )   

0.50     

(1.56 )   

(0.08 ) 

   21,346     

   13,565     

   10,269     

   8,146     

   6,242     

   4,912     

   4,615     

   4,294   

   21,346     

   13,565     

   10,269     

   8,146     

   6,242     

   6,577     

   4,615     

   4,294   

  
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
    
    
    
    
    
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
  
  
  
  
  
  
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
     
    
    
    
     
    
    
    
     
    
    
    
     
    
    
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS—(Continued)  

Note 16. Subsequent Events  

On  April 4,  2011,  CryoPort,  Inc.  (the  “Company”)  named  Mark  Englehart,  53,  as  the  Company’s  Chief  Commercial 
Officer. Mr. Englehart has more than 30 years of marketing, sales and product commercialization experience in the pharmaceutical, 
biotechnology and contract research organization industries.  

On  May 25,  2011,  the  Board  of  Directors  of  CryoPort,  Inc.  (the  “Company”),  elected  Karen  M.  Muller  to  the  Board  of 
Directors to fill the vacancy created by the recent passing of Mr. Hank Bonde. Ms. Muller was expected to be appointed to the Audit 
Committee, Compensation Committee and Governance and Nominating Committee of the Board of Directors on June 23, 2011.  

In April 2011, the Company issued 171,428 shares of common stock upon the exercise of warrants at an average exercise 

price of $0.77 per share for total gross proceeds of $132,000.  

In April 2011, the Company issued 36,090 shares of common stock upon the cashless exercise of a total of 85,714 warrants 

at an average exercise price of $0.77 per share.  

F-34  

   
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Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused 

this Report to be signed on its behalf by the undersigned, thereunto duly authorized.  

SIGNATURES  

Dated: June 27, 2011  

  CRYOPORT, INC. 

By: 

/s/ LARRY G. STAMBAUGH 
Larry G. Stambaugh, 
  President & Chief Executive Officer, and Director 

POWER OF ATTORNEY  

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Larry G. 
Stambaugh, President and Chief Executive  Officer, and Catherine M. Doll, Chief Financial Officer, and each of them, his true and 
lawful attorneys-in-fact and agents, with the full power of substitution and re-substitution, for him and in his name, place and stead, in 
any  and  all  capacities,  to  sign  any  amendments  to  this  report,  and  to  file  the  same,  with  exhibits  thereto  and  other  documents  in 
connection  therewith,  with  the  Securities and Exchange Commission, granting unto each said attorney-in-fact  and  agent  full power 
and authority to do and perform each and every act in person, hereby ratifying and confirming all that said attorney-in-fact and agent, 
or either of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.  

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on 
behalf of the Registrant and in the capacities and on the dates indicated:  

Signature 

/s/ Larry G. Stambaugh 
Larry G. Stambaugh  

/s/ Catherine M. Doll 
Catherine M. Doll  

/s/ Carlton M. Johnson 
Carlton M. Johnson  

/s/ Adam Michelin 
Adam Michelin  

/s/ Karen M. Muller 
Karen M. Muller  

Capacity 

President & Chief Executive Officer (Principal Executive 
Officer), and Director 

Date 

June 27, 2011 

Chief Financial Officer (Principal Financial and Principal 
Accounting Officer) 

June 27, 2011 

Director  

Director  

Director  

31  

June 27, 2011 

June 27, 2011 

June 27, 2011 

   
  
    
    
    
  
    
   
    
    
    
  
  
   
  
  
   
    
    
  
  
  
  
  
  
  
   
  
  
  
  
   
  
  
   
  
  
  
  
   
  
  
   
  
  
  
  
   
  
  
   
  
  
  
  
   
  
  
   
  
  
  
  
   
  
  
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Exhibit 
No. 

   Description 

EXHIBIT INDEX  

3.1   

3.2   

3.3   

3.4   

3.4.1   

3.4.2   

3.4.3   

3.5   

3.6   

3.7   

3.8   

3.9   

3.10   

3.11   

3.12   

3.13   

3.14   

Corporate Charter for G.T.5-Limited issued by the State of Nevada on March 15, 2005. Incorporated by reference 
to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Articles of Incorporation for G.T.5-Limited filed with the State of Nevada in May 25, 1990. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Amendment to Articles of Incorporation of G.T.5-Limited increasing the authorized shares of common stock from 
5,000,000 to 100,000,000 shares of common stock filed with the State of Nevada on October 12, 2004. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Amendment to Articles of Incorporation changing the name of the corporation from G.T.5-Limited to CryoPort, 
Inc. filed with the State of Nevada on March 16, 2005. Incorporated by reference to CryoPort’s Registration 
Statement on Form 10-SB/A4 dated February 23, 2006.  

Amended and Restated Articles of Incorporation dated October 19, 2008. Incorporated by reference to CryoPort’s 
Current Report on Form 8-K filed October 19, 2007.  

Certificate of Amendment to Articles of Incorporation filed with the State of Nevada on November 2, 2009. 
Incorporated by reference to CryoPort’s Amendment No. 1 to Form S-1/A Registration Statement dated 
January 12, 2010.  

Certificate of Amendment to Amended and Restated Articles of Incorporation filed with the State of Nevada on 
February 3, 2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K filed on February 5, 2010.  

Amended and Restated By-Laws of CryoPort, Inc. adopted by the Board of Directors on June 22, 2005 and 
amended by the Certificate of Amendment of Amended and Restated Bylaws of CryoPort, Inc. adopted by the 
Board of Directors on October 9, 2009. Incorporated by reference to CryoPort’s Amendment No. 1 to Form S-1/A 
Registration Statement dated January 12, 2010.  

Articles of Incorporation of CryoPort Systems, Inc. filed with the State of California on December 11, 2000, 
including Corporate Charter for CryoPort Systems, Inc. issued by the State of California on December 13, 2000. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

By-Laws of CryoPort Systems, Inc. adopted by the Board of Directors on December 11, 2000. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

CryoPort, Inc. Stock Certificate Specimen. Incorporated by reference to CryoPort’s Registration Statement on 
Form 10-SB/A4 dated February 23, 2006.  

Code of Conduct for CryoPort, Inc. Incorporated by reference to CryoPort’s Registration Statement on Form 10-
SB/A4 dated February 23, 2006.  

Code of Ethics for Senior Officers of CryoPort, Inc. and subsidiaries. Incorporated by reference to CryoPort’s 
Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Statement of Policy on Insider Trading. Incorporated by reference to CryoPort’s Registration Statement on 
Form 10-SB/A4 dated February 23, 2006.  

CryoPort, Inc. Audit Committee Charter, under which the Audit Committee will operate, adopted by the Board of 
Directors on August 19, 2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 
dated February 23, 2006.  

CryoPort Systems, Inc. 2002 Stock Incentive Plan adopted by the Board of Directors on October 1, 2002. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Stock Option Agreement ISO — Specimen adopted by the Board of Directors on October 1, 2002. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

   
  
  
  
  
  
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
32  

Table of Contents  

Exhibit 
No. 

3.15   

3.16   

   Description 

Stock Option Agreement NSO — Specimen adopted by Board of Directors on October 1, 2002. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Warrant Agreement — Specimen adopted by the Board of Directors on October 1, 2002. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

3.17   

   Patents and Trademarks  

3.17.1   

3.17.2   

3.17.3   

3.17.4   

3.17.5   

3.17.6   

3.17.7   

4.1   

4.1.1   

4.1.2   

CryoPort Systems, Inc. Patent #6,467,642 information sheet and Assignment to CryoPort Systems, Inc. document. 
On File with CryoPort.  

CryoPort Systems, Inc. Patent #6,119,465 information sheet and Assignment to CryoPort Systems, Inc. document. 
On File with CryoPort.  

CryoPort Systems, Inc. Patent #6,539,726 information sheet and Assignment to CryoPort Systems, Inc. document. 
On File with CryoPort.  

CryoPort Systems, Inc. Trademark #7, 583, 478,7 information sheet and Assignment to CryoPort Systems, Inc. 
document. On File with CryoPort.  

CryoPort Systems, Inc. Trademark #7, 586, 797, 8 information sheet and Assignment to CryoPort Systems, Inc. 
document. On File with CryoPort.  

CryoPort Systems, Inc. Trademark #7,748,667,3 information sheet and Assignment to CryoPort Systems, Inc. 
document. On File with CryoPort.  

CryoPort Systems, Inc. Trademark #7,737,454,1 information sheet and Assignment to CryoPort Systems, Inc. 
document. On File with CryoPort.  

Form of Debenture — Original Issue Discount 8% Secured Convertible Debenture dated September 28, 2007. 
Incorporated by reference to CryoPort’s Registration Statement on Form SB-2 dated November 9, 2007.  

Amendment to Convertible Debenture dated February 19, 2008. Incorporated by reference to CryoPort’s Current 
Report on Form 8- K dated March 7, 2008 and referred to as Exhibit 10.1.10.  

Amendment to Convertible Debenture dated April 30, 2008. CryoPort’s Current Report on Form 8-K dated 
April 30, 2008 and referred to as Exhibit 10.1.11.  

4.1.2.1   

Annex to Amendment to Convertible Debenture dated April 30, 2008. CryoPort’s Current Report on Form 8-K 
dated April 30, 2008 and referred to as Exhibit 10.1.11.1.  

4.1.3   

4.1.4   

4.1.5   

4.1.6   

4.1.7   

Amendment to Convertible Debenture dated August 29, 2008. Incorporated by reference to CryoPort’s Current 
Report on Form 8-K dated August 29, 2008.  

Amendment to Convertible Debenture effective January 27, 2009 and dated February 20, 2009. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated February 19, 2009.  

Amendment to Debentures and Warrants with Enable Growth Partners LP, Enable Opportunity Partners LP, 
Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated 
September 1, 2009. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated September 17, 
2009.  

Amendment to Debentures and Warrants, Agreement and Waiver with Enable Growth Partners LP, Enable 
Opportunity Partners LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and 
CryoPort Inc. dated January 12, 2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated 
January 15, 2010.  

Amendment Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified 
Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated February 1, 2010. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated February 3, 2010.  

  
  
  
  
  
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
4.1.8   

Amended and Restated Amendment Agreements with Enable Growth Partners LP, Enable Opportunity Partners 
LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated 
February 19, 2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated February 26, 2010. 

33  

   
  
  
Table of Contents  

Exhibit 
No. 

4.1.9   

4.2   

4.3   

4.4   

4.5   

4.6   

4.7   

4.8   

4.9   

4.10   

4.11   

4.12   

4.13   

4.14   

4.15   

10.1.1   

10.1.2   

10.1.3   

10.1.4   

   Description 

First Amendment to Amended and Restated Amendment Agreements with Enable Growth Partners LP, Enable 
Opportunity Partners LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and 
CryoPort Inc. dated February 23, 2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated February 26, 2010.  

Form of Common Stock Purchase Warrant dated September 28, 2007. Incorporated by reference to CryoPort’s 
Registration Statement on Form SB-2 dated November 9, 2007.  

Original Issue Discount 8% Secured Convertible Debenture dated May 30, 2008. Incorporated by reference to 
CryoPort’s Current Report on Form 8-K dated June 9, 2008.  

Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on 
Form 8-K dated June 9, 2008  

Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on 
Form 8-K dated June 9, 2008  

Form of Warrant and Warrant Certificate in connection with the February 25, 2010 public offering. Incorporated 
by reference to CryoPort’s Amendment No. 5 to Form S-1/A Registration Statement dated February 9, 2010.  

Form of Securities Purchase Agreement in connection with the August to October 2010 private placement. 
Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010.  

Form of First Amendment to Security Purchase Agreement in connection with the August to October 2010 private 
placement. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010.  

Form of Securities Purchase Agreement (Continuation of the Placement) in connection with the August to 
October 2010 private placement. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 
dated October 19, 2010.  

Registration Rights Agreement in connection with the August to October 2010 private placement. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010.  

Form of Joinder to Registration Rights Agreement in connection with the August to October 2010 private 
placement. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010.  

Form of Securities Purchase Agreement in connection with the February 2011 private placement. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-1 dated April 1, 2011.  

Form of Registration Rights Agreement in connection with the February 2011 private placement. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-1 dated April 1, 2011.  

Form of Warrant in connection with the August to October 2010 private placement. Incorporated by reference to 
CryoPort’s Registration Statement on Form S-1/A dated April 22, 2011.  

Form of Warrant in connection with the February 2011 private placement. Incorporated by reference to CryoPort’s 
Registration Statement on Form S-1/A dated April 22, 2011.  

Stock Exchange Agreement associated with the merger of G.T.5-Limited and CryoPort Systems, Inc. signed on 
March 15, 2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated 
February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and D. Petreccia executed on August 26, 2005. Incorporated 
by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and J. Dell executed on September 1, 2005. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and M. Grossman executed on August 25, 2005. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

  
  
  
  
  
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
10.1.5   

10.1.6   

10.1.7   

10.1.8   

Commercial Promissory Note between CryoPort, Inc. and P. Mullens executed on September 2, 2005. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Commercial Promissory Note between CryoPort, Inc. and R. Takahashi executed on August 25, 2005. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

Exclusive and Representation Agreement between CryoPort Systems, Inc. and CryoPort Systems, Ltda. executed 
on August 9, 2001. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated 
February 23, 2006 and referred to as Exhibit 10.1.8.  

Secured Promissory Note and Loan Agreement between Ventana Group, LLC and CryoPort, Inc. dated May 12, 
2006. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006 
and referred to as Exhibit 10.1.9.  

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Table of Contents  

Exhibit 
No. 

10.2   

10.2.1   

10.3   

10.4   

10.4.1   

10.5   

10.6   

10.7   

10.8   

10.9   

10.10   

10.11   

10.12   

10.13   

10.14   

10.15   

10.16   

   Description 

Business Alliance Agreement dated April 27, 2007, by CryoPort, Inc. and American Biologistics Company LLC. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated April 27, 2007 and referred to as 
Exhibit 10.3.  

Corrected Business Alliance Agreement dated April 27, 2007, by CryoPort, Inc. and American Biologistics 
Company LLC. Incorporated by reference to CryoPort’s Current Report on Form 8-K/A dated May 2, 2007 and 
referred to as Exhibit 10.3.1.  

Consultant Agreement dated April 18, 2007 between CryoPort, Inc. and Malone and Associates, LLC. 
Incorporated by reference to CryoPort’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 
and referred to as Exhibit 10.4.  

Lease Agreement dated June 26, 2007 between CryoPort, Inc. and Viking Investors — Barents Sea LLC. 
Incorporated by reference to CryoPort’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 
and referred to as Exhibit 10.5.  

Second Amendment To Lease: Renewal dated August 24, 2009, between CryoPort, Inc. and Viking Inventors-
Barents Sea LLC. Incorporated by reference to CryoPort’s Amendment No. 1 to Form S-1/A Registration 
Statement dated January 12, 2010.  

Securities Purchase Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration 
Statement on Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.6.  

Registration Rights Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration 
Statement on Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.7.  

Security Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on 
Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.8.  

Sitelet Agreement between FedEx Corporate Services, Inc. and CryoPort Systems, Inc. dated January 23, 2008. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated February 1, 2008 and referred to as 
Exhibit 10.9.  

Securities Purchase Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on 
Form 8-K dated June 9, 2008 and referred to as Exhibit 10.10.  

Registration Rights Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on 
Form 8-K dated June 9, 2008 and referred to as Exhibit 10.11.  

Waiver dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated June 9, 
2008 and referred to as Exhibit 10.12.  

Security Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated June 9, 2008 and referred to as Exhibit 10.13.  

Board of Directors Agreement between Larry G. Stambaugh and CryoPort, Inc. dated December 10, 2008. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated December 5, 2008 and referred to as 
Exhibit 10.15.  

Rental Agreement with FedEx Corporate Services and CryoPort, Inc. dated May 15, 2009 (CryoPort has filed a 
Confidential Treatment Request under Rule 24b-5 of the Exchange Act, for parts of this document). Incorporated 
by reference to CryoPort’s Annual Report on Form 10-K for the year ended March 31, 2009 and referred to as 
Exhibit 10.16.  

Settlement Agreement and Mutual Release with Dee Kelly and CryoPort, Inc. dated July 24, 2009. Incorporated 
by reference to CryoPort’s Current Report on Form 8-K dated July 20, 2009 and referred to as Exhibit 10.14.  

Consent, Waiver and Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce 
Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. and its subsidiary 
dated July 30, 2009. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated July 29, 2009 and 
referred to as Exhibit 10.15.  

  
  
  
  
  
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
10.17   

Employment Agreement with Larry G. Stambaugh and CryoPort, Inc. dated August 1, 2009. Incorporated by 
reference to CryoPort’s Current Report dated August 21, 2009 and referred to as Exhibit 10.19.  

35  

   
  
    
  
   
  
  
Table of Contents  

Exhibit 
No. 

10.18   

10.19   

10.20   

10.21   

10.22   

10.23   

10.24   

10.25   

10.26   

10.27   

10.28   

10.29   

10.30   

10.31   

10.32   

10.33   

   Description 

Letter Accepting Consulting Agreement dated October 1, 2007 with Carpe DM, Inc. and CryoPort, Inc. 
Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated March 25, 2009 and 
referred to as Exhibit 10.1.  

Master Consulting and Engineering Services Agreement dated October 9, 2007 with KLATU Networks, LLC and 
CryoPort, Inc. Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated March 25, 
2009 and referred to as Exhibit 10.2.  

Investment Banker Termination Agreement dated April 6, 2009 with Bradley Woods & Co. Ltd., SEPA Capital 
Corp., Edward Fine, and CryoPort, Inc. Incorporated by reference to CryoPort, Inc.’s Registration Statement on 
Form S-8 dated April 13, 2009 and referred to as Exhibit 10.1.  

Attorney-Client Retainer Agreement with Gary Curtis Cannon and CryoPort, Inc. dated December 1, 2007. 
Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated June 11, 2009 and 
referred to as Exhibit 10.3.  

CryoPort, Inc., 2009 Stock Incentive Plan. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated October 9, 2009 and referred to as Exhibit 10.21.  

CryoPort, Inc., Form Incentive Stock Option Award Agreement under the CryoPort, Inc., 2009 Stock Incentive 
Plan. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated October 9, 2009 and referred to 
as Exhibit 10.22.  

Warrant issued to Rodman & Renshaw, LLC in connection with the February 25, 2010 public offering. 
Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010.  

Form of Non-Qualified Stock Option Award Agreement under the CryoPort, Inc. 2009 Stock Incentive Plan. 
Incorporated by reference to CryoPort’s Registration Statement on Form S-8 dated April 27, 2010.  

Underwriting Agreement with Rodman & Renshaw, LLC and CryoPort in connection with the February 25, 2010 
public offering. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 
2010.  

Letter of Engagement with Maxim Group, LLC and CryoPort dated as of June 16, 2010. Incorporated by reference 
to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010.  

Second Amendment to Engagement Agreement with Maxim Group, LLC. Incorporated by reference to CryoPort’s 
Registration Statement on Form S-1 dated October 19, 2010.  

Selling Agency Agreement for CryoPort, Inc. Stock and Warrants with Emergent Financial Group, Inc. and 
CryoPort dated as of July 27, 2010. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 
dated October 19, 2010.  

Addendum to Selling Agency Agreement for CryoPort, Inc. Stock and Warrants with Emergent Financial Group, 
Inc. and CryoPort dated as of August 31, 2010. Incorporated by reference to CryoPort’s Registration Statement on 
Form S-1 dated October 19, 2010.  

Agreement dated as of January 13, 2010, between CryoPort, Inc. and Federal Express Corporation. Incorporated 
by reference to CryoPort’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2010.**  

First Amendment to Master Consulting and Engineering Services Agreement dated as of April 23, 2009, between 
CryoPort, Inc. and KLATU Networks, LLC. Incorporated by reference to CryoPort’s Registration Statement on 
Form S-1 dated October 19, 2010.  

Second Amendment to Master Consulting and Engineering Services Agreement dated as of November 1, 2010, 
between CryoPort, Inc. and KLATU Networks, LLC. Incorporated by reference to CryoPort’s Registration 
Statement on Form S-1 dated October 19, 2010.  

10.34   

Selling Agency Agreement between CryoPort, Inc. and Emergent Financial Group, Inc. dated as of February 4, 
2011. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated April 1, 2011.  

  
  
  
  
  
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
  
  
  
    
  
   
10.35   

Consent to Appointment of Co-Agent Agreement between CryoPort, Inc. and Emergent Financial Group, Inc. 
dated as of February 10, 2011. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated 
April 1, 2011.  

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Table of Contents  

Exhibit 
No. 

10.36   

   Description 

Letter Agreement between CryoPort, Inc. and Maxim Group LLC dated February 11, 2011. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-1 dated April 1, 2011.  

13.1   

   Consolidated Financial Statements and related Notes thereto.*  

21   

   Subsidiaries of Registrant*  

23.1   

   Consent of Independent Registered Public Accounting Firm — KMJ Corbin & Company LLP.*  

31.1   

   Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer.*  

31.2   

   Rule 13a-14(a)/15d-14(a) Certification of Chief Financial Officer.*  

32.1   

   Certification Pursuant to U.S.C. §1350 of Chief Executive Officer.*  

32.2   

   Certification Pursuant to U.S.C. §1350 of Chief Financial Officer.*  

  Filed herewith.  

* 
**    Portions omitted pursuant to a request for confidential treatment filed separately with the Commission.  

37  

   
  
  
  
  
  
  
  
  
    
  
   
  
  
  
    
  
   
  
  
    
  
   
  
  
    
  
   
  
  
    
  
   
  
  
    
  
   
  
  
    
  
   
  
  
    
  
   
  
  
  
     
  
CryoPort Systems, Inc.  

CRYOPORT, INC.  
Subsidiaries of Registrant  

EXHIBIT 21 

   
   
Consent of Independent Registered Public Accounting Firm  

We consent to the incorporation by reference in the Registration Statement No. 333-166327 on Form S-8 of our report dated June 27, 
2011,  with  respect  to  the  consolidated  financial  statements  of  CryoPort,  Inc.  included  in  this  Annual  Report  on  Form  10-K  of 
CryoPort, Inc. for the years ended March 31, 2011 and 2010.  

EXHIBIT 23.1 

/s/ KMJ Corbin & Company, LLP  

Costa Mesa, California  
June 27, 2011  

   
   
Certification of Chief Executive Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

EXHIBIT 31.1 

I, Larry G. Stambaugh, certify that:  

1. I have reviewed this annual report on Form 10-K of CryoPort, Inc.;  

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact 
necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with 
respect to the period covered by this report;  

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all 
material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in 
this report;  

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as 
defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act 
Rules 13a-15(f) and 15d-15(f)) for the registrant and have:  

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our 
supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us 
by others within those entities, particularly during the period in which this report is being prepared;  

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed 
under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial 
statements for external purposes in accordance with generally accepted accounting principles;  

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions 

about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such 
evaluation; and  

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the 
registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, 
or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and  

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial 
reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the 
equivalent functions):  

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting 
which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; 
and  

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the 

registrant’s internal control over financial reporting.  

Dated: June 27, 2011  

Signed: 

/s/ LARRY G. STAMBAUGH 
Larry G. Stambaugh 
  President & Chief Executive Officer, and Director 

   
   
  
    
    
    
  
  
   
  
  
   
    
    
Certification of Chief Financial Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

EXHIBIT 31.2 

I, Catherine M. Doll, certify that:  

1. I have reviewed this annual report on Form 10-K of CryoPort, Inc.;  

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact 
necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with 
respect to the period covered by this report;  

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all 
material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in 
this report;  

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as 
defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act 
Rules 13a-15(f) and 15d-15(f)) for the registrant and have:  

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our 
supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us 
by others within those entities, particularly during the period in which this report is being prepared;  

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed 
under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial 
statements for external purposes in accordance with generally accepted accounting principles;  

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions 

about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such 
evaluation; and  

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the 
registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, 
or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and  

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial 
reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the 
equivalent functions):  

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting 
which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; 
and  

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the 

registrant’s internal control over financial reporting.  

Dated: June 27, 2011  

Signed: 

/s/ CATHERINE M. DOLL 
Catherine M. Doll 
  Chief Financial Officer 

   
   
  
    
    
    
  
  
   
  
  
   
    
    
Certification Pursuant to U.S.C. §1350 of Chief Executive Officer  

I, Larry G. Stambaugh., President and Chief Executive Officer of CryoPort, Inc. (the “Company”), certify, pursuant to Rule 13

(a)-14(b) or Rule 15(d)-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2011 (the “Report”) fully complies 
with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of 
operations of the Company.  

EXHIBIT 32.1 

Dated: June 27, 2011  

/s/ Larry G. Stambaugh 
Larry G. Stambaugh, Chairman,  
Chief Executive Officer  

A signed original of this written statement required by Section 906 has been provided to CryoPort, Inc. and will be retained 

by CryoPort, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.  

This Certification is being furnished pursuant to Rule 15(d) and shall not be deemed “filed” for purposes of Section 18 of 

the Exchange Act (15 U.S.C. 78r), or otherwise subject to the liability of that section. This Certification shall not be deemed 
incorporated by reference into any filing under the Securities Act or the Exchange Act, except to the extent that the Company 
specifically incorporates it by reference.  

   
   
  
  
  
   
  
  
  
  
Certification Pursuant to U.S.C. §1350 of Chief Financial Officer  

I, Catherine M. Doll Chief Financial Officer of CryoPort, Inc. (the “Company”), certify, pursuant to Rule 13(a)-14(b) or Rule 15

(d)-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2011 (the “Report”) fully complies 
with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of 
operations of the Company.  

EXHIBIT 32.2 

Dated: June 27, 2011  

/s/ Catherine M. Doll 
Catherine M. Doll,  
Chief Financial Officer, Chief Accounting Officer  

A signed original of this written statement required by Section 906 has been provided to CryoPort, Inc. and will be retained 

by CryoPort, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.  

This Certification is being furnished pursuant to Rule 15(d) and shall not be deemed “filed” for purposes of Section 18 of 

the Exchange Act (15 U.S.C. 78r), or otherwise subject to the liability of that section. This Certification shall not be deemed 
incorporated by reference into any filing under the Securities Act or the Exchange Act, except to the extent that the Company 
specifically incorporates it by reference.