Quarterlytics / Industrials / Integrated Freight & Logistics / Cryoport, Inc.

Cryoport, Inc.

cyrx · NASDAQ Industrials
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Exchange NASDAQ
Sector Industrials
Industry Integrated Freight & Logistics
Employees 1090
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FY2012 Annual Report · Cryoport, Inc.
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Table of Contents  

UNITED STATES  
SECURITIES AND EXCHANGE COMMISSION  
Washington, D.C. 20549  

FORM 10-K  

(Mark One)  
 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT 

OF 1934 
For the fiscal year ended March 31, 2012  

OR  

(cid:1) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE 

ACT OF 1934 

For the transition period from                 to                   

Commission file number: 001-34632  

CRYOPORT, INC.  

(Exact name of Registrant as specified in its charter)  

Nevada 
(State or other jurisdiction of  
incorporation or organization)  

20382 Barents Sea Circle,  
Lake Forest, California  
(Address of principal executive offices) 

88-0313393 
(I.R.S. Employer  
Identification No.)  

92630 
(Zip Code) 

(949) 470-2300  
(Registrant’s telephone number, including area code)  

Securities registered pursuant to Section 12(b) of the Act:  

Title of Each Class 
Common Stock, $0.001 par value 

Name of Each Exchange on Which Registered 
OTC Market 

Securities registered pursuant to Section 12(g) of the Act:  
Common Stock, $0.001  
Warrants to Purchase Common Stock  

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes   (cid:1)     No     

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.    Yes   (cid:1)     No     

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act 
of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject 
to such filing requirements for the past 90 days.    Yes        No   (cid:1)  

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data 
File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or 
for such shorter period that the registrant was required to submit and post such files).    Yes        No   (cid:1)  

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405) is not contained herein, and will not 
be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this 
Form 10-K or any amendment to this Form 10-K.     

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting 
company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. 
(check one):  

      
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
Large accelerated filer    (cid:1) 
   (cid:1) 

Non-accelerated filer 

   (cid:1) 
   Accelerated filer 
   Smaller reporting company      

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).    Yes   (cid:1)     No     

The aggregate market value of Common Stock held by non-affiliates as of September 30, 2011 was $30,910,665 (1)  

Number of shares of Common Stock outstanding as of June 19, 2012: 37,760,628  

DOCUMENTS INCORPORATED BY REFERENCE  

Part III of this report incorporates certain information by reference from the registrant’s proxy statement for the annual meeting of stockholders, 
which proxy statement will be filed no later than 120 days after the close of the registrant’s fiscal year ended March 31, 2012.  

(1)  Excludes 1,254,235 shares of common stock held by directors and officers, and any stockholder whose ownership exceeds five percent of 

the shares outstanding as of September 30, 2011. 

   
   
   
         
  
Table of Contents  

Item 1 Business  
Item 1A Risk Factors  
Item 1B Unresolved Staff Comments  
Item 2 Properties  
Item 3 Legal Proceedings  
Item 4 Mine Safety Disclosures  

CRYOPORT, INC.  

Fiscal Year 2012 10-K Annual Report  

Table of Contents  

PART I 

PART II 

Item  5 Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities  
Item 6 Selected Financial Data  
Item 7 Management’s Discussion and Analysis of Financial Condition and Results of Operations  
Item 7A Quantitative and Qualitative Disclosures About Market Risk  
Item 8 Financial Statements and Supplementary Data  
Item 9 Changes in and Disagreements with Accountants on Accounting and Financial Disclosures  
Item 9A Controls and Procedures  
Item 9B Other Information  

Item 10 Directors, Executive Officers and Corporate Governance  
Item 11 Executive Compensation  
Item  12 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters  
Item 13 Certain Relationships and Related Transactions, and Director Independence  
Item 14 Principal Accountant Fees and Services  

PART III 

Item 15 Exhibits and Consolidated Financial Statement Schedules  
Signatures  

PART IV 

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PART I  

In this Annual Report, the terms “we”, “us”, “our”, “Company” and “CryoPort” refer to CryoPort, Inc., and our wholly owned subsidiary, 
CryoPort Systems, Inc. This Annual Report contains forward-looking statements that involve risks and uncertainties. The inclusion of forward-
looking statements should not be regarded as a representation by us or any other person that the objectives or plans will be achieved because our 
actual results may differ materially from any forward-looking statement. The words “may,” “should,” “plans,” “believe,” “anticipate,” 
“estimate,” “expect,” their opposites and similar expressions are intended to identify forward-looking statements, but the absence of these words 
does not necessarily mean that a statement is not forward-looking. We caution readers that such statements are not guarantees of future 
performance or events and are subject to a number of factors that may tend to influence the accuracy of the statements, including but not limited 
to, those risk factors outlined in the section titled “Risk Factors” as well as those discussed elsewhere in this Annual Report. You should not 
unduly rely on these forward-looking statements, which speak only as of the date of this Annual Report. We undertake no obligation to publicly 
revise any forward-looking statement to reflect circumstances or events after the date of this Annual Report or to reflect the occurrence of 
unanticipated events. You should, however, review the factors and risks we describe in the reports that we file from time to time with the 
Securities and Exchange Commission (“SEC”) after the date of this Annual Report.  

In addition, we own or have rights to the registered trademark CryoPort  (both alone and with a design logo) and CryoPort Express  (both alone 
® 
and with a design logo). All other Company names, registered trademarks, trademarks and service marks included in this Annual Report are 
trademarks, registered trademarks, service marks or trade names of their respective owners.  

® 

Item 1. 

BUS INESS 

Overview  

We are a provider of an innovative cold chain frozen shipping system dedicated to providing superior, affordable cryogenic shipping 
solutions that ensure the stable transportation temperature, of high value, temperature sensitive materials. We have developed cost effective 
reusable cryogenic transport containers (referred to as a “shipper”) capable of transporting biological, environmental and other temperature 
sensitive materials at temperatures below minus 150° Celsius. These dry vapor shippers and shipping system are one of the first significant 
alternatives to dry ice shipping and achieve 10-plus day holding times compared to one to two day holding times typically achieved with dry ice.  

Our value proposition comes from both providing stable temperatures during transportation with an environmentally friendly, long lasting 

shipper, and through our value added monitoring of transportation services that offer a simple hassle-free solution for our customers. These 
value-added services include an internet-based web portal that enables the customer to initiate scheduling, shipping and tracking of the progress 
and status of a shipment, and provides in-transit temperature and custody transfer monitoring services of the shipper. The CryoPort service also 
provides a fully ready charged shipper containing all freight bills, customs documents and regulatory paperwork for the entire journey of the 
shipper to our customers at their pickup and delivery locations.  

® 

Our principal focus has been the commercialization of our solution as well as further development of our CryoPort Express  Portal, an 
innovative IT solution for shipping and tracking high-value specimens through overnight shipping companies and specialty couriers, and our 
CryoPort Express  Shippers, dry vapor cryogenic shippers for the transport of biological and pharmaceutical materials. A dry vapor cryogenic 
shipper is a container that uses liquid nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide 
stable storage temperatures below minus 150° Celsius. The dry vapor shipper is designed using innovative, proprietary, and patented technology 
which prevents spillage of liquid nitrogen and pressure build up as the liquid nitrogen evaporates. A proprietary retention system is employed to 
ensure that liquid nitrogen is retained inside the vacuum container, even when placed upside-down or on its side, as is often the case when in the 
custody of a shipping company. Biological specimens are stored in a specimen chamber, referred to as a “well,” inside the container and 
refrigeration is provided by non-hazardous cold nitrogen gas evolving from the liquid nitrogen entrapped within the retention system 
surrounding the well. Biological specimens transported using our cryogenic shipper can include clinical samples, diagnostics, live cell 
pharmaceutical products (such as cancer vaccines, semen and embryos, infectious substances) and other items that require and/or are protected 
through continuous exposure to frozen or cryogenic temperatures.  

® 

During our early years, our limited revenue was derived from the sale of our reusable product line. Our current business plan focuses on 

per-use leasing of the shipping container and added-value services that will be used by us to provide an end-to-end and cost-optimized shipping 
solution to life science companies moving pharmaceutical and biological samples in clinical trials and pharmaceutical distribution.  

We entered into our first strategic relationship with a global courier on January 13, 2010 when we signed an agreement with Federal 

Express Corporation (“FedEx”) pursuant to which we lease to FedEx such number of our cryogenic shippers that FedEx, from time to time, 
orders for its customers. Under this agreement, FedEx has the right to, on a non-exclusive basis, promote market and sell transportation of our 
shippers and related value-added goods and services, such as our CryoPort  Portal and CryoPort Express  Smart Pak System. On January 24, 
2011 we announced that FedEx had launched its deep frozen shipping solution using our CryoPort Express  Dry Shipper. We have also 
integrated our web portal IT with FedEx’s IT to provide access to tracking and tracing scans  

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during FedEx shipping. On September 2, 2010, we entered into an agreement with DHL Express (USA), Inc. (“DHL”) that gives DHL life 
science customers direct access to our web-based order entry and tracking portal to order the CryoPort Express  Shipper and receive preferred 
DHL shipping rates. The agreement covers DHL shipping discounts that may be used to support our customers using the CryoPort Express 
shipping solution. In connection with the agreement, we have integrated our proprietary web portal to DHL’s tracking and billing systems. DHL 
life science customers now have a seamless way of shipping their critical biological material worldwide. The IT integration with DHL was 
completed during our fourth quarter of fiscal year 2011.  

® 

® 

Corporate History and Structure  

We are a Nevada corporation originally incorporated under the name G.T.5-Limited (“GT5”) on May 25, 1990. In connection with a Share 

Exchange Agreement, on March 15, 2005 we changed our name to CryoPort, Inc. and acquired all of the issued and outstanding shares of 
common stock of CryoPort Systems, Inc., a California corporation, in exchange for 2,410,811 shares of our common stock (which represented 
approximately 81% of the total issued and outstanding shares of common stock following the close of the transaction). CryoPort Systems, Inc., 
which was originally formed in 1999 as a California limited liability company, and subsequently reorganized into a California corporation on 
December 11, 2000, remains the operating company under CryoPort, Inc. Our principal executive offices are located 20382 Barents Sea Circle, 
Lake Forest, CA 92630. The telephone number of our principal executive offices is (619) 481-6800, and our main corporate website is 
www.cryoport.com. The information on, or that can be accessed through, our website is not part of this Annual Report.  

Our Products and Pipeline  

The CryoPort Express  System  

® 

The CryoPort Express  System consists of the CryoPort Express  Portal, which programmatically manages order entry and all aspects of 

® 

® 

® 

® 

shipping operations, CryoPort Express  Shippers, the CryoPort Express  Smart Pak data logger, and CryoPort Express  Analytics, which 
monitors shipment performance metrics and evaluates temperature-monitoring data collected by the data logger during shipment. The CryoPort 
Express  System is focused on improving the reliability of frozen shipping while reducing the customers’ overall operating costs. This is 
accomplished by providing a complete end-to-end solution for the transport and monitoring of frozen or cryogenically preserved biological or 
pharmaceutical materials shipped though overnight shipping companies and specialty couriers. Certain of the intellectual property underlying the 
CryoPort Express  System (other than that related to the CryoPort Express  Shippers, has been, and continues to be, developed under a contract 
with an outside software development company, with the underlying technology licensed to us for exclusive use in our field of use.  

® 

® 

® 

® 

In addition, we provide a containment bag which is used in connection with the shipment of infectious or dangerous goods using the 

CryoPort Express  Shippers and other accessories used in the shipment of biological and pharmaceutical specimens.  

® 

CryoPort Express  Portal  

® 

® 

The CryoPort Express  Portal is used by CryoPort, our customers and our business partners to automate the entry of orders, prepare 
customs documentation and to facilitate status and location monitoring of shipped orders while in transit It is used by CryoPort to manage 
shipping operations and to reduce administrative costs typically provisioned through manual labor relating to order-entry, order processing, 
preparation of shipping documents and back-office accounting. It is also used to support the high level of customer service expected by the 
industry. Certain features of the CryoPort Express  Portal reduce operating costs and facilitate the scaling of CryoPort’s business, but more 
importantly they offer significant value to the customer in terms of cost avoidance and risk mitigation. Examples of these features include 
automation of order entry, development of Key Performance Indicators (“KPI”) to support our efforts for continuous process improvements in 
our business, and programmatic exception monitoring to detect and sometimes anticipate delays in the shipping process, often before the 
customer or the shipping company becomes aware of them. In the future we will add rate and mode optimization and in-transit monitoring of 
temperature, location and state of health (discussed below), via wireless communications.  

® 

The CryoPort Express  Portal also serves as the communications nerve center for the management, collection and analysis of Smart Pak 

® 

data collected from Smart Pak data loggers in the field. Data is converted into pre-designed reports containing valuable and often actionable 
information that becomes the quality control standard or “pedigree” of the shipment. This information can be utilized by CryoPort to provide 
valuable feedback to the customer relating to their shipments.  

The CryPort Express  Portal was developed for shipments that are required to maintain specific temperatures, such as ambient (between 

® 

20 and 25°C), chilled (between 2 and 8°C) or frozen (minus 10°C or less) to ensure that the shipped specimen is not subject to degradation. Our 
current focus is on frozen shipments within the life sciences industry using the shippers described below.  

The CryoPort Express  Shippers  

® 

Our CryoPort Express  Shippers are cryogenic dry vapor shippers capable of maintaining cryogenic temperatures of minus 150° Celsius or 

® 

below for a period of 10 or more days. A dry cryogenic shipper is a device that uses liquid nitrogen contained inside a vacuum insulated bottle 
which serves as a refrigerant to provide stable storage temperatures below minus 150° Celsius. Our CryoPort Express  shippers are designed to 
ensure that there is no pressure build up as the liquid nitrogen evaporates or spillage of liquid  

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nitrogen. We have developed a proprietary retention system to ensure that liquid nitrogen stays inside the vacuum container, which allows the 
shipper to be designated as a dry shipper meeting International Air Transport Association (“IATA”) requirements. Biological or pharmaceutical 
specimens are stored in a specimen chamber, referred to as a “well”, inside the container and refrigeration is provided by cold nitrogen gas 
evolving from the liquid nitrogen entrapped within the retention system. Specimens that may be transported using our cryogenic shipper include 
live cell pharmaceutical products such as cancer vaccines, diagnostic materials, semen and embryos, infectious substances and other items that 
require continuous exposure to frozen or cryogenic temperatures (e.g., temperatures below minus 150° Celsius).  

We are currently offering two sizes of dry vapor shippers, the CryoPort Express  Standard Shipper with a storage capacity of up to 75 
0.2ml vials and the CryoPort Express  High Volume Shipper which was introduced in January of 2012 with a capacity of up to 500 0.2ml 
vials. The CryoPort Express  Standard Shipper  

® 

® 

® 

The technology underlying the CryoPort Express  Shipper was developed by modifying and advancing technology from our first 

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generation of reusable cryogenic dry shippers. While our CryoPort Express  Shippers share many of the characteristics and basic design details 
of our earlier shippers, we are manufacturing our CryoPort Express  Shippers from alternative, lower cost and lower weight materials, which 
reduces overall operating costs. We maintain ongoing development efforts related to our shippers which are principally focused on material 
properties, particularly those properties related to the low temperature requirement, the vacuum retention characteristics, such as the permeability 
of the materials, and lower cost and lower weight materials in an effort to meet the market needs for achieving a lower cost frozen and cryogenic 
shipping solution. Other advances additional to the development work on the cryogenic container include both an improved liquid nitrogen 
retention system and a secondary protective, spill proof packaging system. This secondary system, outer packaging has a low cost that lends 
itself to disposability, and it is made of recyclable materials. Further, it adds an additional liquid nitrogen retention capability to further assure 
compliance with IATA and ICAO regulations that prohibit egress of liquid nitrogen from the shipping package. IACO stands for the 
International Civil Aviation Organization, which is a United Nations organization that develops regulations for the safe transport of dangerous 
goods by air.  

The CryoPort Express  Standard Shippers are lightweight, low-cost, re-usable dry vapor liquid nitrogen storage containers that we believe 

® 

combine the best features of packaging, cryogenics and high vacuum technology. A CryoPort Express  Standard Shipper is composed of an 
aluminum metallic dewar flask, with a well for holding the biological material in the inner chamber. The dewar flask, or “thermos bottle,” is an 
example of a practical device in which the conduction, convection and radiation of heat are reduced as much as possible. The inner chamber of 
the shipper is surrounded by a high surface, low-density material which retains the liquid nitrogen in-situ by absorption, adsorption and surface 
tension. Absorption is defined as the taking up of matter in bulk by other matter, as in the dissolving of a gas by a liquid, whereas adsorption is 
the surface retention of solid, liquid or gas molecules, atoms or ions by a solid or liquid. This material absorbs liquid nitrogen several times faster 
than currently used materials, while providing the shipper with a hold time and capacity to transport biological materials safely and conveniently. 
The annular space between the inner and outer dewar chambers is evacuated to a very high vacuum (10-6 Torr). The specimen-holding chamber 
has a primary cap to enclose the specimens, and a removable and replaceable secondary cap to further enclose the specimen-holding container 
and to contain the liquid nitrogen. The entire dewar vessel is then wrapped in a plurality of insulating and cushioning materials and placed in a 
disposable outer packaging made of recyclable material. The CryoPort Express  Standard Shipper has a storage capacity of up to 75 0.2ml vials. 

® 

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The CryoPort Express  High Volume Shipper  
® 

The CryoPort Express  High Volume Shipper also uses a dry vapor liquid nitrogen (LN2) technology to maintain below -150° C 

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temperatures with a dynamic shipping endurance of 10 days. The High Volume dry shipper is based on the same dry vapor technology as 
CryoPort’s original standard dry shipper and utilizes an absorbent material to hold LN2, thus providing the extended endurance time and IATA 
validation as a non-hazardous shipping container. The High Volume dry shipper is reusable and recyclable, making it a highly sustainable and 
cost effective method of transporting life science materials. The CryoPort Express  High Volume Shipper has a storage capacity of up to 500 
0.2ml vials.  

® 

We believe the CryoPort solution is the best and most cost effective solution available in the market that satisfies customer needs and 
regulatory requirements relating to the shipment of temperature-critical, frozen and refrigerated transport of biological materials, such as the 
pharmaceutical clinical trials, gene biotechnology, infectious materials handling, and animal and human reproduction markets. Due to our 
proprietary technology and innovative design, our shippers are less prone to losing functional hold time when not kept in an upright position than 
the competing products because such proprietary technology and innovative design prevent the spilling or leakage of the liquid nitrogen when 
the container is tipped or on its side which would adversely affect the functional hold time of the container.  

An important feature of the CryoPort Express  Shippers is their compliance with the stringent packaging requirements of IATA Packing 

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Instructions 602 and 650, respectively. These instructions include the internal pressure (hydraulic) and drop performance requirements.  

The CryoPort Express  Smart Pak  

® 

Temperature monitoring is a high value feature from our customers’ perspective as it is an effective and reliable method to determine that 
the shipment materials were not damaged or degraded during shipment due to temperature fluctuations. Phase II of our Smart Pak System which 
is a self-contained automated data logger capable of recording the internal and external temperatures of samples shipped in our CryoPort Express 
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Shippers was launched in fiscal year 2010 and is currently used in every shipment.  

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Phase III of our Smart Pak System consists of developing and rolling out a smart chip with wireless connectivity to enable our customers to 

monitor a shipper’s location, specimen temperature and overall state of health via our web portal. A key feature of the Phase III product is 
automatic downloading of data which requires no customer intervention. We are currently developing the requirements for Phase III.  

CryoPort Express  Analytics  

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Our continued development of the CryoPort Express  Portal is a strategic element of our business strategy and the CryoPort Express 

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Portal system has been designed to support planned future features with this thought in mind. Analytics is a term used by IT professionals to 
refer to performance benchmarks or Key Performance Indicators (KPI’s) that management utilizes to measure performance against desired 
standards. Examples include time-based metrics for order processing time and on-time deliveries by our shipping partners, as well as profiling 
shipping lanes to determine average transit times and predicting an exception if a shipment is taking longer than it should based on historical 
metrics. The analytical results are being utilized by CryoPort to render consultative customer services.  

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Biological Material Holders  

We have also developed a patented containment bag which is used in connection with the shipment of infectious or dangerous goods using 
the CryoPort Express  Shippers. Up to five vials, watertight primary receptacles are placed onto aluminum holders and up to fifteen holders (75 
vials) are placed into an absorbent pouch which is designed to absorb the entire contents of all the vials in the event of leakage. This pouch 
containing up to 75 vials is then placed in a watertight secondary packaging Tyvek bag capable of withstanding cryogenic temperatures, and then 
sealed. This bag is then placed into the well of the cryogenic shipper.  

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Other Product Candidates and Development Activities  

We are continuing our research and development efforts which are expected to lead to the introduction of additional dry vapor shippers, 
including a smaller size unit constructed of lower cost materials and utilizing high volume manufacturing methods. We are also exploring the use 
of alternative phase change materials in place of liquid nitrogen in order to seek entry into the ambient temperature (between 20° and 25° 
Celsius) and chilled temperature (2° to 8° Celsius) shipping markets.  

Government Regulation  

The shipping of diagnostic specimens, infectious substances and dangerous goods, whether via air or ground, falls under the jurisdiction of 

many state, federal and international agencies. The quality of the containers, packaging materials and insulation that protect a specimen 
determine whether or not it will arrive in a usable condition. Many of the regulations for transporting dangerous goods in the United States are 
determined by international rules formulated under the auspices of the United Nations. For example, the ICAO is the United Nations 
organization that develops regulations (Technical Instructions) for the safe transport of dangerous goods by air. If shipment is by air, compliance 
with the rules established by IATA is required. IATA is a trade association made up of airlines and air cargo couriers that publishes annual 
editions of the IATA Dangerous Goods Regulations. These regulations interpret and add to the ICAO Technical Instructions to reflect industry 
practices. Additionally, the CDC has regulations (published in the Code of Federal Regulations) for interstate shipping of specimens, and OSHA 
also addresses the safe handling of Class 6.2 Substances. Our CryoPort Express  Shippers meet Packing Instructions 602 and 650 and are 
certified for the shipment of Class 6.2 Dangerous Goods per the requirements of the ICAO Technical Instructions for the Safe Transport of 
Dangerous Goods by Air and IATA. Our present and planned future versions of the CryoPort Smart Pak data logger will likely be subject to 
regulation by Federal Aviation Administration (“FAA”), Federal Communications Commission (“FCC”), Food and Drug Administration 
(“FDA”), International Air Association (“IATA”) and possibly other agencies which may be difficult to determine on a global basis.  

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We are also subject to numerous other federal, state and local laws relating to such matters as safe working conditions, manufacturing 
practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. We may incur significant 
costs to comply with such laws and regulations now or in the future.  

Manufacturing and Raw Materials  

Manufacturing . The component parts for our products are primarily manufactured at third party manufacturing facilities. We also have a 
warehouse at our facility in Lake Forest, California, where we are capable of manufacturing certain parts and fully assemble our products. Most 
of the components that we use in the manufacture of our products are available from more than one qualified supplier. For some components, 
however, there are relatively few alternate sources of supply and the establishment of additional or replacement suppliers may not be 
accomplished immediately, however, we have identified alternate qualified suppliers which we believe could replace existing suppliers. Should 
this occur, we believe that with our current level of dewars and production rate we have enough to cover a four to six week gap in maximum 
disruption of production. There are no specific agreements with any manufacturer nor are there any long term commitments to any manufacturer. 
We believe that most of the manufactures currently used by us could be replaced within a short period of time as none have a proprietary 
component or a substantial capital investment specific to our products.  

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Our production and manufacturing process incorporates innovative technologies developed for aerospace and other industries which are 

cost effective, easier to use and more functional than the traditional dry ice devices and other methods currently used for the shipment of 
temperature-sensitive materials. Our manufacturing process uses non-hazardous cleaning solutions which are provided and disposed of by a 
supplier approved by the Environmental Protection Agency (the “EPA”). EPA compliance costs for us are therefore negligible.  

The CryoPort Express  High Volume Shipper is purchased from a third party and modified using our proprietary technology and know-

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how.  

Raw Materials . Various common raw materials are used in the manufacture of our products and in the development of our technologies. 

These raw materials are generally available from several alternate distributors and manufactures. We have not experienced any significant 
difficulty in obtaining these raw materials and we do not consider raw material availability to be a significant factor in our business.  

Patents and Proprietary Rights  

In order to remain competitive, we must develop and maintain protection on the proprietary aspects of our technologies. We rely on a 

combination of patents, copyrights, trademarks, trade secret laws and confidentiality agreements to protect our intellectual property rights. We 
currently own three registered United States trademarks and three issued United States patents primarily covering various aspects of our 
products. In addition, we have filed a patent application for various aspects of our shipper and web-portal, which includes, in part, various 
aspects of our business model referred to as the CryoPort Express  System, and we intend to file additional patent applications to strengthen our 
intellectual property rights. The technology covered by the above indicated issued patents relates to matters specific to the use of liquid nitrogen 
dewars in connection with the shipment of biological materials. The concepts include those of disposability, package configuration details, liquid 
nitrogen retention systems, systems related to thermal performance, systems related to packaging integrity, and matters generally relevant to the 
containment of liquid nitrogen. Similarly, the trademarks mentioned relate to the cryogenic temperature shipping activity. Issued patents and 
trademarks currently owned by us include:  

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Type: 
Patent  
Patent  
Patent  
Trademark  
Trademark  
Trademark  

No. 
   6,467,642       
   6,119,465       
   6,539,726       
  7,583,478,7       
  7,748,667,3       
  7,737,454,1       

Issued 
  Oct. 22, 2002       
  Sep. 19, 2000       
   Apr. 1, 2003       
   Oct. 8, 2002       
   Feb. 3, 2009       
  Mar. 17, 2009       

Expiration 
  Oct. 21, 2022    
  Sep. 18, 2020    
  Mar 31, 2023    
N/A    
N/A    
N/A    

Our success depends to a significant degree upon our ability to develop proprietary products and technologies and to obtain patent 

coverage for these products and technologies. We intend to file trademark and patent applications covering any newly developed products, 
methods and technologies. However, there can be no guarantee that any of our pending or future filed applications will be issued as patents. 
There can be no guarantee that the U.S. Patent and Trademark Office or some third party will not initiate an interference proceeding involving 
any of our pending applications or issued patents. Finally, there can be no guarantee that our issued patents or future issued patents, if any, will 
provide adequate protection from competition.  

Patents provide some degree of protection for our proprietary technology. However, the pursuit and assertion of patent rights involve 
complex legal and factual determinations and, therefore, are characterized by significant uncertainty. In addition, the laws governing patent 
issuance and the scope of patent coverage continue to evolve. Moreover, the patent rights we possess or are pursuing generally cover our 
technologies to varying degrees. As a result, we cannot ensure that patents will issue from any of our patent applications, or that any of its issued 
patents will offer meaningful protection. In addition, our issued patents may be successfully challenged, invalidated, circumvented or rendered 
unenforceable so that our patent rights may not create an effective barrier to competition. Moreover, the laws of some foreign countries may not 
protect our proprietary rights to the same extent, as do the laws of the United States. There can be no assurance that any patents issued to us will 
provide a legal basis for establishing an exclusive market for our products or provide us with any competitive advantages, or that patents of 
others will not have an adverse effect on our ability to do business or to continue to use our technologies freely.  

We may be subject to third parties filing claims that our technologies or products infringe on their intellectual property. We cannot predict 

whether third parties will assert such claims against us or whether those claims will hurt our business. If we are forced to defend against such 
claims, regardless of their merit, we may face costly litigation and diversion of management’s attention and resources. As a result of any such 
disputes, we may have to develop, at a substantial cost, non-infringing technology or enter into licensing agreements. These agreements may be 
unavailable on terms acceptable to it, or at all, which could seriously harm our business or financial condition.  

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We also rely on trade secret protection of our intellectual property. We attempt to protect trade secrets by entering into confidentiality 
agreements with third parties, employees and consultants, although, in the past, we have not always obtained such agreements. It is possible that 
these agreements may be breached, invalidated or rendered unenforceable, and if so, our trade secrets could be disclosed to our competitors. 
Despite the measures we have taken to protect our intellectual property, parties to such agreements may breach confidentiality provisions in our 
contracts or infringe or misappropriate our patents, copyrights, trademarks, trade secrets and other proprietary rights. In addition, third parties 
may independently discover or invent competitive technologies, or reverse engineer our trade secrets or other technology. Therefore, the 
measures we are taking to protect our proprietary technology may not be adequate.  

Customers and Distribution  

As a result of growing globalization, including with respect to such areas as life science clinical trials and distribution of pharmaceutical 
products, the requirement for effective solutions for keeping certain clinical samples and pharmaceutical products at frozen temperatures takes 
on added significance due to extended shipping times, custom delays and logistics challenges. Today, such goods are traditionally shipped in 
styrofoam cardboard insulated containers packed with dry ice, gel/freezer packs or a combination thereof. The current dry ice solutions have 
limitations that severely limit their effective and efficient use for both short and long-distances (e.g., international). Conventional dry ice 
shipments often require labor intensive “re-icing” operations resulting in higher labor and shipping costs.  

We believe our patented cryogenic shippers make us well positioned to take advantage of the growing demand for effective and efficient 

international transport of temperature sensitive materials resulting from continued globalization. Of particular significance is the trend within the 
pharmaceutical and biotechnology industries toward globalization. We believe this presents a new and unique opportunity for pharmaceutical 
companies, particularly early or developmental stage companies, to conduct some of their clinical trials in foreign countries where the cost may 
be cheaper and/or because the foreign countries significantly larger population provides a larger pool of potential patients suffering from the 
indication that the drug candidate is being designed to treat. We also provide domestic shipping solutions in situations and regions where there is 
a high priority placed on maintaining the integrity of materials shipped at cryogenic temperatures and where we can be cost effective.  

To date, most of our customers have been in the pharmaceutical or medical industries. As we initially focus our efforts to increase 
revenues, we believe that the primary target customers for our CryoPort Express  System are concentrated in the following markets, for the 
following reasons:  

® 

• 

• 

• 

• 

• 

   Pharmaceutical clinical trials / contract research organizations;  
   Gene biotechnology;  
   Transport of infectious materials and dangerous goods;  
   Pharmaceutical distribution; and  
   Fertility clinics/artificial insemination.  

Pharmaceutical Clinical Trials . Every pharmaceutical company developing a new drug must be approved by the FDA who conducts 
clinical trials to, among other things, test the safety and efficacy of the potential new drug. Presently, a significant amount of clinical trial activity 
is managed by a number of large Clinical Research Organizations (“CROs”). Due to the growing downsizing trend in the pharmaceutical 
industry, CROs are going to obtain an increasing share of the clinical trial market.  

In connection with the clinical trials, due to globalization the companies may enroll patients from all over the world who regularly submit a 

blood or other specimen at the local hospital, doctor’s office or laboratory. These samples are then sent to specified testing laboratories, which 
may be local or in another country. The testing laboratories will typically set the requirements for the storage and shipment of blood specimens. 
In addition, several of the drugs used by the patients require frozen shipping to the sites of the clinical trials. While both domestic and 
international shipping of these specimens is accomplished using dry ice today, international shipments especially present several problems, as 
dry ice, under the best of circumstances, can only provide freezing for one to two days, in the absence of re-icing (which is quite costly). Because 
shipments of packages internationally can take longer than one to two days or be delayed due to flight cancellations, incorrect destinations, labor 
problems, ground logistics, customs delays and safety reasons, dry ice is not always a reliable and cost effective option. Clinical trial specimens 
are often irreplaceable because each one represents clinical data at a prescribed point in time, in a series of specimens on a given patient, who 
may be participating in a trial for years. Sample integrity during the shipping process is vital to retaining the maximum number of patients in 
each trial. Our shippers are ideally suited for this market, as our longer hold time ensures that specimens can be sent over long distances with 
minimal concern that they will arrive in a condition that will cause their exclusion from the trial. There are also many instances in domestic 
shipments where the CryoPort Express  Shipper will provide higher reliability and be cost effective.  

® 

Furthermore, the IATA requires that all airborne shipments of laboratory specimens be transmitted in either IATA Instruction 650 or 602 

certified packaging. We have developed and obtained IATA certification of the CryoPort Express  System, which is ideally suited for this 
market, in particular due to the elimination of the cost to return the reusable shipper.  

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Gene Biotechnology . The gene biotechnology market includes basic and applied research and development in diverse areas such as stem 
cells, cloning, gene therapy, DNA tumor vaccines, tissue engineering, genomics, and blood products. Companies participating in the foregoing 
fields rely on the frozen transport of specimens in connection with their research and development efforts, for which our CryoPort Express 
Shippers are ideally suited.  

® 

Transport of Infectious Materials and Dangerous Goods . The transport of infectious materials must be classified as such and must 

maintain strict adherence to regulations that protect public safety while maintaining the viability of the material being shipped. Some blood 
products are considered infective and must be treated as such. Pharmaceutical companies, private research laboratories and hospitals ship tissue 
cultures and microbiology specimens, which are also potentially infectious materials, between a variety of entities, including private and public 
health reference laboratories. Almost all specimens in this infectious materials category require either a refrigerated or a frozen environment. We 
believe our CryoPort Express  Shippers are ideally suited to meet the shipping requirements of this market.  

® 

Partly in response to the attack on the World Trade Center and the anthrax scare, government officials and health care professionals are 
focusing renewed attention on the possibility of attacks involving biological and chemical weapons such as anthrax, smallpox and sarin gas. 
Efforts expended on research and development to counteract biowarfare agents requires the frozen transport of these agents to and from facilities 
conducting the research and development. Vaccine research, including methods of vaccine delivery, also requires frozen transport. We believe 
our CryoPort Express  Shippers are ideally suited to this type of research and development.  

® 

Pharmaceutical Distribution . The current focus for the CryoPort Express  System also includes the area of pharmaceutical distribution. 

® 

There are a significant number of therapeutic drugs and vaccines currently or soon to be, undergoing clinical trials. After the FDA approves them 
for commercial marketing, it will be necessary for the manufacturers to have a reliable and economical method of distribution to the physician 
who will administer the product to the patient. Although there are not now a large number of drugs requiring cryogenic transport, there are a 
number in the development pipeline. It is likely that the most efficient and reliable method of distribution will be to ship a single dosage to the 
administering physician. These drugs are typically identified to individual patients and therefore will require a complete tracking history from 
the manufacturer to the patient. The most reliable method of doing this is to ship a unit dosage specifically for each patient. Because the drugs 
require maintenance at frozen or cryogenic temperatures, each such shipment will require a frozen or cryogenic shipping package. CryoPort 
anticipates being in a position to service that need.  

Fertility Clinics and In Vitro Fertilization (“IVF”) . Maintaining cryogenic temperatures during shipping and transfer of in vitro 

fertilization specimens like eggs, sperm, or embryos is critical for cell integrity in order to retain viability, stabilize the cells, and ensure 
reproducible results and successful IVF treatment. We estimate that artificial insemination procedures in the United States account for at least 
50,000 doses of semen annually. Since relatively few sperm banks provide donor semen, frozen shipping is almost always involved. CryoPort 
anticipates that this market will continue to increase as this practice gains acceptance in new areas of the world.  

In addition to the above markets, our longer-term plans include expanding into new markets including, the diagnostics, food, 

environmental, semiconductor and petroleum industries.  

Sales and Marketing  

We currently have two senior sales directors in the United States, one senior sales director in Europe, one inside sales representative and a 
senior director of marketing promoting the use of our CryoPort Express  System on a direct basis in addition to the sales and marketing efforts 
® 
provided by our strategic partner FedEx. Given the global nature of our business, our sales and marketing initiatives cover the Americas, Europe 
and Asia. For the fiscal year ended March 31, 2012, net revenues from three major customers accounted for 31% of our total net revenues.  

Our geographical revenues for the fiscal year ended March 31, 2012 were as follows:  

USA  
Europe  
Asia  
Rest of World  

  45.8 %  
  30.8 %  
  12.1 %  
  11.3 %  

We recently entered into an agreement with FedEx and we plan to further expand our revenues and marketing efforts through the 

establishment of additional strategic relationships with global couriers and, subject to available financial resources, the hiring of additional sales 
and marketing personnel.  

CryoPort Operations Centers  

In addition to the services provided through our facility in Lake Forest, California, we have contracted with a third party to establish a 

European operations center in Leiden, the Netherlands in November 2011 to support the expansion of our CryoPort Express dry shipping 
solution in Europe. The European operations center provides warehousing, shipping, receiving, refurbishing and recycling services for our 
shipping containers. This approach is a cost-effective way to initiate operations in Europe and scale up as our business grows throughout that 
region. We also have a small operations center in New Delhi, India and established an operations center in Singapore for the Asia region during 
fiscal year 2012.  

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Industry and Competition  

Our products and services are sold into a rapidly growing niche of the packaging industry focused on the temperature sensitive packaging 

and shipping of biological materials. Expenditures for “value added” packaging for frozen transport have been increasing for the past several 
years and, due in part to continued globalization, are expected to continue to increase even more in the future as more domestic and international 
biotechnology firms introduce pharmaceutical products that require continuous refrigeration at cryogenic temperatures. We believe this will 
require a greater dependence on passively controlled temperature transport systems (i.e., systems having no external power source).  

We believe that growth in the following markets has resulted in the need for increased efficiencies and greater flexibility in the temperature 

sensitive packaging market:  

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

   Pharmaceutical clinical trials, including transport of tissue culture samples;  
   Pharmaceutical commercial product distribution;  
   Transportation of diagnostic specimens;  
   Transportation of infectious materials;  
   Intra laboratory diagnostic testing;  
   Transport of temperature-sensitive specimens by courier;  
   Analysis of biological samples;  
   Environmental sampling;  
   Gene and stem cell biotechnology and vaccine production; and  
   Food engineering.  

Many of the biological products in these above markets require transport in a frozen state as well as the need for shipping containers which 
have the ability to maintain a frozen, cryogenic environment (e.g., minus 150° Celsius) for a period ranging from two to ten days (depending on 
the distance and mode of shipment). These products include semen, embryo, tissue, tissue cultures, cultures of viruses and bacteria, enzymes, 
DNA materials, vaccines and certain pharmaceutical products. In some instances, transport of these products requires temperatures at, or 
approaching, minus 196° Celsius.  

One problem faced by many companies operating in these specialized markets is the limited number of cryogenic shipping systems serving 

their needs, particularly in the areas of pharmaceutical companies conducting clinical trials. The currently adopted protocol and the most 
common method for packaging frozen transport in these industries is the use of solid state carbon dioxide (dry ice). Dry ice is used extensively in 
shipping to maintain a frozen state for a period of one to four days. Dry ice is used in the transport of many biological products, such as 
pharmaceuticals, laboratory specimens and certain infectious materials that do not require true cryogenic temperatures. The common approach to 
shipping these items via ground freight is to pack the product in a container, such as an expanded polystyrene (styrofoam) box or a molded 
polyurethane box, with a variable quantity of dry ice. The box is taped or strapped shut and shipped to its destination with freight charges based 
on its initial shipping weight. All dry ice shipping is considered dangerous goods shipping.  

With respect to shipments via specialized courier services, there is no standardized method or device currently in use for the purpose of 
transporting temperature-sensitive frozen biological specimens. One common method for courier transport of biological materials is to place 
frozen specimens, refrigerated specimens, and ambient specimens into a compartmentalized container, similar in size to a 55 quart Coleman or 
Igloo cooler. The freezer compartment in the container is loaded with a quantity of dry ice at minus 78° Celsius, while the refrigerated 
compartment at 8° Celsius utilizes ice substitutes.  

Two manufacturers of the polystyrene and polyurethane containers frequently used in the shipping and courier transport of dry ice frozen 

specimens are Insulated Shipping Containers, Inc. and Tegrant (formerly SCA Thermosafe). When these containers are used with dry ice, the 
average sublimation rate (e.g., the rate at which dry ice turns from a solid to a gaseous state) in a container with a 1  /  inch wall thickness is 
slightly less than three pounds per 24 hours. Other existing refrigerant systems employ the use of gel packs and ice substitutes for temperature 
maintenance. Gels and eutectic solutions (phase changing materials) with a wide range of phasing temperatures have been developed in recent 
years to meet the needs of products with varying specific temperature control requirements.  

1 

2 

The use of dry ice and ice substitutes, however, regardless of external packaging used, are frequently inadequate because they do not 
provide low enough storage temperatures and, in the case of dry ice, last for only a few days without re-icing. As a result, companies run the risk 
of increased costs due to lost specimens and additional shipping charges due to the need to re-ice.  

Some of the other disadvantages to using dry ice for shipping or transporting temperature sensitive products are as follows:  

• 

• 

• 

• 

• 

   Availability of a dry ice source;  
   Handling and storage of the dry ice;  
   Cost of the dry ice;  
   Compliance with local, state and federal regulations relating to the storage and use of dry ice;  
   Dangerous goods shipping regulations;  

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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   Weight of containers when packed with dry ice;  

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• 

• 

• 

   Securing a shipping container with a high enough R-value (which is a measure of thermal resistance) to hold the dry ice and product 
for the required time period;  
   Securing a shipping container that meets the requirements of IATA, the DOT, the CDC, and other regulatory agencies; and  
   The emission of green house gases into the environment.  

Due to the limitations of dry ice, shipment of specimens at true cryogenic temperatures is best accomplished using liquid nitrogen dry 

vapor shippers, or by shipping over actual liquid nitrogen. While such shippers provide solutions to the issues encountered when shipping with 
dry ice, they too are experiencing some criticisms by users or potential users. For example, the cost for these products typically can range from 
$650 to $3,000 per unit, which can substantially limit their use for the transport of many common biologics, particularly with respect to small 
quantities such as is the case with direct to the physician drug delivery. Because of the initial cost and limited production of these containers, 
they are designed to be reusable. However, the cost of returning these heavy containers can be significant, particularly in international markets, 
because most applications require only one-way shipping. We expect to provide a cost effective solution compared to dry ice. We believe we 
will provide an overall cost savings of 10% to 20% for international and specialty shipments compared to dry ice, while at the same time 
providing a higher level of support and related services.  

Another problem with these existing systems relates to the hold time of the unit in a normal, upright position versus the hold time when the 

unit is placed on its side or inverted. If a container is laying on its side or is inverted the liquid nitrogen is prone to leaking out of the container 
due to a combination of factors, including a shift in the equilibrium height of the liquid nitrogen in the absorbent material and the relocation of 
the point of gravity, which affects the hold time and compromises the dependability of the dry shipper, particularly when used in circumstances 
requiring lengthy shipping times. Due to the use of our proprietary technology, our CryoPort Express  Shippers are not prone to leakage when 
on their side or inverted, thereby protecting the integrity of our shipper’s hold time.  

® 

Within our intended markets for our CryoPort Express  Shippers, there is limited known competition. We intend to become competitive 

® 

® 

® 

by reason of our improved technology in our products and through the use of our service enabled business model. The CryoPort Express 
® 
System provides a simple and cost effective solution for the frozen or cryogenic transport of biological or pharmaceutical materials. This 
solution uses our innovative dewar and is supported by the CryoPort Express  Portal, our web-based order-entry system, which manages the 
scheduling and shipping of the CryoPort Express  Shippers. In addition, the traditional dry ice shippers and suppliers, such as MVE/Chart 
Industries, Taylor Wharton and Air Liquide, offer various models of dry vapor liquid nitrogen shippers that are not cost efficient for multi-use 
and multi-shipment purposes due to their significantly greater unit costs and unit weight (which may substantially increase the shipping cost). On 
the other hand, they are more established and have larger organizations and have greater financial, operational, sales and marketing resources 
and experience in research and development than we do. Factors that we believe give us a competitive advantage are attributable to our shipping 
container which allows our shipper to retain liquid nitrogen when placed in non-upright positions, the overall “leak- proofness” of our package 
which determines compliance with shipping regulations and the overall weight and volume of the package which determines shipping costs, and 
our business model represented by the merged integration of our shipper with CryoPort Express  Portal and Smart Pak datalogger into a 
seamless shipping, tracking and monitoring solution. Other companies that offer potentially competitive products include Industrial Insulation 
Systems, which offers cryogenic transport units and has partnered with Marathon Products Inc., a manufacturer and global supplier of wireless 
temperature data collecting devices used for documenting environmentally sensitive products through the cold chain and Kodiak Thermal 
Technologies, Inc. which offers, among other containers, a repeat use active-cool container that uses free piston stirling cycle technology. While 
not having their own shipping devices, BioStorage Technologies is potentially a competitive company through their management services 
offered for cold-chain logistics and long term biomaterial storage. Cryogena offers a single use disposable LN2 shipper with better performance 
than dry-ice, but it does not perform as well and is not as cost-effective as the CryoPort solution when all costs are considered. In addition, 
BioMatrica, Inc. is developing and offering technology that stabilizes biological samples and research materials at room temperature. They 
presently offer these technologies primarily to research and academic institutions, however, their technology may eventually enter the broader 
cold-chain market.  

® 

Research and Development  

Our research and development efforts are focused on continually improving the features of the CryoPort Express  System including the 

® 

web based customer service portal and the CryoPort Express  Shippers. Further these efforts are expected to lead to the introduction of shippers 
of varying sizes based on market requirements, constructed of lower cost materials and utilizing high volume manufacturing methods that will 
make it practical to provide the cryogenic packages offered by the CryoPort Express  System. Other research and development effort has been 
directed toward improvements to the liquid nitrogen retention system to render it more reliable in the general shipping environment and to the 
design of the outer packaging. Alternative phase change materials in place of liquid nitrogen may be used to increase the potential markets these 
shippers can serve such as ambient and 2-8°C markets. Our research and development expenditures for the fiscal years ended March 31, 2012 
and 2011 were $491,849 and $449,129, respectively.  

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Employees  

As of June 19, 2012, we had nineteen full-time employees and three consultants.  

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Insurance  

We currently maintain general liability insurance, with coverage in the amount of $1 million per occurrence, subject to a $2 million annual 

limitation. Claims may be made against us that exceed these limits. In fiscal year 2012, we did not experience any claims against our 
professional liability insurance.  

Our liability policy is an “occurrence” based policy. Thus, our policy is complete when we purchased it and following cancellation of the 
policy it continues to provide coverage for future claims based on conduct that took place during the policy term. However, our insurance may 
not protect us against liability because our policies typically have various exceptions to the claims covered and also require us to assume some 
costs of the claim even though a portion of the claim may be covered. In addition, if we expand into new markets, we may not be aware of the 
need for, or be able to obtain insurance coverage for such activities or, if insurance is obtained, the dollar amount of any liabilities incurred could 
exceed our insurance coverage. A partially or completely uninsured claim, if successful and of significant magnitude, could have a material 
adverse effect on our business, financial condition and results of operations.  

We also maintain product liability insurance with coverage in the amount of $1,000,000 per year.  

ITEM 1A.  RISK FACTORS 

This Annual Report on Form 10-K contains forward-looking information based on our current expectations. Because our actual results 
may differ materially from any forward-looking statements made by or on behalf of CryoPort, this section includes a discussion of important 
factors that could affect our actual future results, including, but not limited to, our potential product and service revenues, acceptance of our 
products and services, expenses, net income(loss) and earnings(loss) per common share.  

Risks Related to Our Business  

We have incurred significant losses to date and may continue to incur losses.  

We have incurred net losses in each fiscal year since we commenced operations. The following table represents net losses incurred for each 

of our last two fiscal years:  

Fiscal Year Ended March 31, 2012  
Fiscal Year Ended March 31, 2011  

Net Loss 
$ 7,832,928    
$ 6,152,278    

As of March 31, 2012, we had an accumulated deficit of $59,929,015. While we expect to continue to derive revenues from our current 

® 

products and services, in order to achieve and sustain profitable operations, we must successfully commercialize and launch our CryoPort 
Express  System, significantly expand our market presence and increase revenues. We may continue to incur losses in the future and may never 
generate revenues sufficient to become profitable or to sustain profitability. Continuing losses may impair our ability to raise the additional 
capital required to continue and expand our operations.  

Our auditors have expressed doubt about our ability to continue as a going concern.  

The Report of Independent Registered Public Accounting Firm to our March 31, 2012 consolidated financial statements includes an 
explanatory paragraph stating that the recurring losses and negative cash flows from operations since inception and our cash and cash equivalent 
balance at March 31, 2012 raise substantial doubt about our ability to continue as a going concern. The consolidated financial statements do not 
include any adjustments that might result from the outcome of this uncertainty.  

If we are unable to obtain additional funding, we may have to reduce or discontinue our business operations.  

As of June 19, 2012, we had cash and cash equivalents of $3,260,715. We have expended substantial funds on the research and 

development of our products and IT systems. As a result, we have historically experienced negative cash flows from operations and we expect to 
continue to experience negative cash flows from operations in the future. Therefore, our ability to continue and expand our operations is highly 
dependent on the amount of cash and cash equivalents on hand combined with our ability to raise additional capital to fund our future operations. 

We anticipate, based on currently proposed plans and assumptions relating to our ability to market and sell our products (but not including 
any additional strategic relationships with global couriers), that our cash on hand, together with projected cash flows, will satisfy our operational 
and capital requirements at least through the fourth quarter of our fiscal year 2013. There are a number of uncertainties associated with our 
financial projections that could reduce or delay our future projected revenues and cash-inflows, including, but not limited to, our ability to 
increase our customer base and revenues, manage and leverage our relationship with FedEx and enter into strategic relationships with additional 
global couriers. If our projected revenues and cash-inflows are reduced or delayed, we may not have sufficient capital to operate through the 
fourth quarter of our fiscal year 2013 unless we raise more capital. Additionally, if we are unable to realize satisfactory revenue in the near 
future, we will be required to seek additional financing to continue our operations beyond that period. We will also require additional financing 
to expand into other markets and further develop  

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and market our products. We have no current arrangements with respect to any additional financing. Consequently, there can be no assurance 
that any additional financing on commercially reasonable terms, or at all, will be available when needed. The inability to obtain additional 
capital may reduce our ability to continue to conduct business operations. Any additional equity financing may involve substantial dilution to our 
then existing stockholders. In addition, raising additional funding may be complicated by certain provisions in the securities purchase 
agreements and related transaction documents, as amended, entered into in connection with our prior convertible debenture financings. The 
uncertainties surrounding our future cash inflows have raised substantial doubt regarding our ability to continue as a going concern.  

If we are not successful in establishing strategic relationships with global couriers, we may not be able to successfully increase revenues 
and cashflow which could adversely affect our operations.  

We believe that our near term success is best achieved by establishing strategic relationships with global couriers, such as our recent 
agreements with FedEx and DHL. Such relationships will enable us to provide a seamless, end-to-end shipping solution to customers and allow 
us to leverage the couriers’ established express, ground and freight infrastructures and penetrate new markets with minimal investment. Further, 
we expect that the global couriers will utilize their sales forces to promote and sell our frozen shipping services. If we are not successful in 
launching our relationship with FedEx or DHL or establishing additional relationships with global couriers, our sales and marketing efforts will 
be significantly impacted and anticipated revenue growth will be substantially delayed which could have an adverse affect on our operations.  

Our agreements with FedEx and DHL may not result in a significant increase in our revenues or cashflow.  

On January 13, 2010, we entered into an agreement with FedEx pursuant to which we lease to FedEx such number of our cryogenic 
shippers that FedEx shall, from time to time, order for its customers. FedEx has the right to on a non-exclusive basis, promote, market and sell 
transportation of our shippers and our related value-added goods and services, such as our web portal and CryoPort Express  Smart Pak System. 
Because our agreement with FedEx does not contain any requirement that FedEx lease a minimum number of shippers from us during the term 
of the agreement, we may not experience a significant increase in our revenues or cashflows as a result of this agreement. On September 2, 2010, 
we entered into an agreement with DHL that will give DHL life sciences customers direct access to our web-based order entry and tracking 
portal to order our CryoPort Express  Shippers and preferred DHL shipping rates. Although the agreement provides shipping discounts that may 
be used to support our customers using our CryoPort Express  shipping solution, DHL will not be promoting, marketing or selling transportation 
of our shippers or services, which may not lead to any increase in our revenues.  

® 

® 

® 

Current economic conditions and capital markets are in a period of disruption and instability which could adversely affect our ability to 
access the capital markets, and thus adversely affect our business and liquidity.  

The current economic conditions and financial crisis have had, and will continue to have, a negative impact on our ability to access the 
capital markets, and thus have a negative impact on our business and liquidity. The shortage of liquidity and credit combined with substantial 
losses in worldwide equity markets could lead to an extended worldwide recession. We may face significant challenges if conditions in the 
capital markets do not improve and we do not achieve positive cash flow from operations. Our ability to access the capital markets may be 
severely restricted at a time when we need to access such markets, which could have a negative impact on our business plans, including the 
commercialization and launch of our CryoPort Express  System and other research and development activities. Even if we are able to raise 
capital, it may not be at a price or on terms that are favorable to us. We cannot predict the occurrence of future financial disruptions or how long 
the current market conditions may continue.  

® 

The sale of substantial shares of our common stock may depress our stock price.  

As of June 19, 2012, there were 37,760,628 shares of our common stock outstanding. Substantially all of these shares of common stock are 
eligible for trading in the public market. The market price of our common stock may decline if our stockholders sell a large number of shares of 
our common stock in the public market, or the market perceives that such sales may occur.  

We could also issue up to 41,104,926 shares of our common stock including shares to be issued upon conversion of the outstanding 
balance of our convertible debentures and upon the exercise of outstanding warrants and options or reserved for future issuance under our stock 
incentive plans, as further described in the following table:  

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Common stock issuable upon conversion of the outstanding balance of our 

convertible debentures  

Common stock issuable upon exercise of outstanding warrants  
Common stock issuable upon exercise of outstanding options or reserved for 

future incentive awards under our stock incentive plans  

Total  

12  

Number of  
Shares of  
Common Stock 

Issuable or  
Reserved for  
Issuance 

19,522    
  37,144,503    

   3,940,901    
  41,104,926    

   
  
   
 
  
   
  
   
   
   
    
   
  
   
   
    
   
  
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Of the total options and warrants outstanding as of June 19, 2012, options and warrants exercisable for an aggregate of 14,701 shares of 
common stock would be considered dilutive to the value of our stockholders’ interest in CryoPort because we would receive upon exercise of 
such options and warrants an amount per share that is less than the market price of our common stock on June 19, 2012.  

We will have difficulty increasing our revenues if we experience delays, difficulties or unanticipated costs in establishing the sales, 
distribution and marketing capabilities necessary to successfully commercialize our products.  

We are continuing to develop sales, distribution and marketing capabilities in the Americas, Europe and Asia. It will be expensive and 
time-consuming for us to develop a global marketing and sales network. Moreover, we may choose, or find it necessary, to enter into additional 
strategic collaborations to sell, market and distribute our products. We may not be able to provide adequate incentive to our sales force or to 
establish and maintain favorable distribution and marketing collaborations with other companies to promote our products. In addition, any third 
party with whom we have established a marketing and distribution relationship may not devote sufficient time to the marketing and sales of our 
products thereby exposing us to potential expenses in exiting such distribution agreements. We, and any of our third party collaborators, must 
also market our products in compliance with federal, state, local and international laws relating to the provision of incentives and inducements. 
Violation of these laws can result in substantial penalties. Therefore, if we are unable to successfully motivate and expand our marketing and 
sales force and further develop our sales and marketing capabilities, or if our distributors fail to promote our products, we will have difficulty 
increasing our revenues.  

Our ability to grow and compete in our industry will be hampered if we are unable to retain the continued service of our key professionals 
or to identify, hire and retain additional qualified professionals.  

A critical factor to our business is our ability to attract and retain qualified professionals including key employees and consultants. We are 

continually at risk of losing current professionals or being unable to hire additional professionals as needed. If we are unable to attract new 
qualified employees, our ability to grow will be adversely affected. If we are unable to retain current employees or strategic consultants, our 
financial condition and ability to maintain operations may be adversely affected.  

If we are unable to retain a new chief executive officer in a timely manner, our business and operations could be adversely affected.  

Our former chief executive officer, Larry Stambaugh, resigned on April 5, 2012. Presently the duties of the chief executive officer are 

being fulfilled by the members of our board of directors while our board of directors searches for a qualified replacement chief executive 
officer. In the event that our board of directors does not find a suitable replacement chief executive officer in a timely manner, the lack of a 
permanent full-time chief executive officer could have an adverse effect on business and operations and impair our ability to increase revenues.  

We are dependent on new products and services, the lack of which would harm our competitive position.  

Our future revenue stream depends to a large degree on our ability to bring new products and services to market on a timely basis. We 
must continue to make significant investments in research and development in order to continue to develop new products and services, enhance 
existing products and services, and achieve market acceptance of such products and services. We may incur problems in the future in innovating 
and introducing new products and services. Our development stage products and services may not be successfully completed or, if developed, 
may not achieve significant customer acceptance. If we are unable to successfully define, develop and introduce new, competitive products and 
services and enhance existing products and services, our future results of operations would be adversely affected. Development and 
manufacturing schedules for technology products and services are difficult to predict, and we might not achieve timely initial customer 
shipments of new products or launch of services. The timely availability of these products and services and their acceptance by customers are 
important to our future success. A delay in new or enhanced product or service introductions could have a significant impact on our results of 
operations.  

Because of these risks, our research and development efforts may not result in any commercially viable products or services. If significant 

portions of these development efforts are not successfully completed, or any new or enhanced products or services are not commercially 
successful, our business, financial condition and results of operations may be materially harmed.  

If we successfully develop products and/or services, but those products and/or services do not achieve and maintain market acceptance, 
our business will not be profitable.  

The degree of acceptance of our CryoPort Express  Shippers and/or CryoPort Express  System, or any future product or services, by our 
current target markets, and any other markets to which we attempt to sell our products and services, and our profitability and growth will depend 
on a number of factors including, among others:  

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   our shippers’ ability to perform and preserve the integrity of the materials shipped;  
   relative convenience and ease of use of our shipper and/or web portal;  
   availability of alternative products;  

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   pricing and cost effectiveness;  
   effectiveness of our or our collaborators’ sales and marketing strategy; and  
   the adoption cycles of our targeted customers.  

If any products or services we may develop do not achieve market acceptance, then we may not generate sufficient revenue to achieve or 

maintain profitability.  

In addition, even if our products and services achieve market acceptance, we may not be able to maintain that market acceptance over time 
if new products or services are introduced that are more favorably received than our products and services, are more cost effective, or render our 
products obsolete.  

The product adoption cycle of our target customers tends to be very lengthy, which continues to adversely affect our ability to increase 
revenues.  

We offer our solution primarily to companies in the life sciences industry. These companies operate within a heavily regulated 
environment and as such, changing vendors and distribution practices typically require a number of steps which may include the audit of our 
facilities, review of our procedures, qualifying us as a vendor, and performing test shipments. This process can take several months or longer to 
complete prior to a company fully adopting the Cryoport Express solution. In addition, any such adoption may be on a gradual basis such that the 
customer progressively ramps up use of our Cryoport Express solution following adoption. The slow adoption process continues to adversely 
affect our ability to increase revenues.  

We are dependent on an outside party for the continued development of our CryoPort Express  Portal  

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Our proprietary CryoPort Express  Portal is a software system used by our customers and business partners to automate the entry of 

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orders, prepare customs documentation and facilitate status and location monitoring of shipped orders while in transit. The continued 
development of this system is contracted with an outside software development company. If this developer becomes unable or unwilling to 
continue work on scheduled projects, and an alternative developer cannot be secured, we may not be able to implement needed enhancements to 
the system. Furthermore, if we terminate our agreement with this developer and cannot reach an agreement or fail to fulfill an agreement for the 
termination, we could lose our license to use this software. Failure to proceed with enhancements or the loss of our license for the system would 
adversely affect our ability to generate new business and serve existing customers, resulting in a reduction in revenue.  

Our success depends, in part, on our ability to obtain patent protection for our products and business model, preserve our trade secrets, 
and operate without infringing the proprietary rights of others.  

Our policy is to seek to protect our proprietary position by, among other methods, filing United States patent applications related to our 

technology, inventions and improvements that are important to the development of our business. We have three issued U.S. patents and one 
recently filed provisional patent application, all relating to various aspects of our products and services. Our patents or provisional patent 
application may be challenged, invalidated or circumvented in the future or the rights granted may not provide a competitive advantage. We 
intend to vigorously protect and defend our intellectual property. Costly and time-consuming litigation brought by us may be necessary to 
enforce our patents and to protect our trade secrets and know-how, or to determine the enforceability, scope and validity of the proprietary rights 
of others.  

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We also rely upon trade secrets, technical know-how and continuing technological innovation to develop and maintain our competitive 

position. In the past our employees, consultants, advisors and suppliers have not always executed confidentiality agreements and invention 
assignment and work for hire agreements in connection with their employment, consulting, or advisory relationships. Consequently, we may not 
have adequate remedies available to us to protect our intellectual property should one of these parties attempt to use our trade secrets or refuse to 
assign any rights he or she may have in any intellectual property he or she developed for us. Additionally, our competitors may independently 
develop substantially equivalent proprietary information and techniques or otherwise gain access to our proprietary technology, or we may not 
be able to meaningfully protect our rights in unpatented proprietary technology.  

We cannot assure you that our current and potential competitors and other third parties have not filed (or in the future will not file) patent 

applications for (or have not received or in the future will not receive) patents or obtain additional proprietary rights that will prevent, limit or 
interfere with our ability to make, use or sell our products either in the United States or internationally. In the event we are required to license 
patents issued to third parties, such licenses may not be available or, if available, may not be available on terms acceptable to us. In addition, we 
cannot assure you that we would be successful in any attempt to redesign our products or processes to avoid infringement or that any such 
redesign could be accomplished in a cost-effective manner. Accordingly, an adverse determination in a judicial or administrative proceeding or 
failure to obtain necessary licenses could prevent us from manufacturing and selling our products or offering our services, which would harm our 
business.  

We are not aware of any third party that is infringing any of our patents or trademarks nor do we believe that we are infringing on the 

patents or trademarks of any other person or organization.  

Our products may contain errors or defects, which could result in damage to our reputation, lost revenues, diverted development resources 
and increased service costs and litigation.  

Our products must meet stringent requirements and we must develop our products quickly to keep pace with the rapidly changing market. 
Products and services as sophisticated as ours could contain undetected errors or defects, especially when first introduced or when new models 
or versions are released. In general, our products may not be free from errors or defects after commercial shipments have begun, which could 
result in damage to our reputation, lost revenues, diverted development resources, increased customer service and support costs, and litigation. 
The costs incurred in correcting any product errors or defects may be substantial and could adversely affect our business, results of operations 
and financial condition.  

If we experience manufacturing delays or interruptions in production, then we may experience customer dissatisfaction and our 
reputation could suffer.  

If we fail to produce enough shippers at our own manufacturing facility or at a third party manufacturing facility, or if we fail to complete 

our shipper recycling processes as planned, we may be unable to deliver shippers to our customers on a timely basis, which could lead to 
customer dissatisfaction and could harm our reputation and ability to compete. We currently acquire various component parts for our shippers 
from various independent manufacturers in the United States. We would likely experience significant delays or cessation in producing our 
shippers if a labor strike, natural disaster or other supply disruption were to occur at any of our main suppliers. If we are unable to procure a 
component from one of our manufacturers, we may be required to enter into arrangements with one or more alternative manufacturing 
companies which may cause delays in producing our shippers. In addition, because we depend on third party manufacturers, our profit margins 
may be lower, which will make it more difficult for us to achieve profitability. To date, we have not experienced any material delay that has 
adversely impacted our operations. As our business develops and the quantity of production increases, it becomes more likely that such problems 
could arise.  

Because we rely on a limited number of suppliers, we may experience difficulty in meeting our customers’ demands for our products in a 
timely manner or within budget.  

We currently purchase key components of our products from a variety of outside sources. Some of these components may only be 
available to us through a few sources, however, management has identified alternative materials and suppliers should the need arise. We 
generally do not have long-term agreements with any of our suppliers. Consequently, in the event that our suppliers delay or interrupt the supply 
of components for any reason, we could potentially experience higher product costs and longer lead times in order fulfillment.  

Our CryoPort Express  Portal may be subject to intentional disruption that could adversely impact our reputation and future revenues.  

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We have implemented our CryoPort Express  Portal which is used by our customers and business partners to automate the entry of orders, 

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prepare customs documentation and facilitate status and location monitoring of shipped orders while in transit. Although we believe we have 
sufficient controls in place to prevent intentional disruptions, we could be a target of attacks specifically designed to impede the performance of 
the CryoPort Express  Portal. Similarly, experienced computer programmers may attempt to penetrate our CryoPort Express  Portal in an effort 
to search for and misappropriate proprietary or confidential information or cause interruptions of our services. Because the techniques used by 
such computer programmers to access or sabotage networks change frequently and may not be recognized until launched against a target, we 
may be unable to anticipate these techniques. Our activities could be adversely affected and our reputation, brand and future sales harmed if 
these intentionally disruptive efforts are successful.  

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Our products and services may expose us to liability in excess of our current insurance coverage.  

Our products and services involve significant risks of liability, which may substantially exceed the revenues we derive from them. We 

cannot predict the magnitude of these potential liabilities.  

We currently maintain general liability insurance, with coverage in the amount of $1 million per occurrence, subject to a $2 million annual 
limitation, and product liability insurance with a $1 million annual coverage limitation. Claims may be made against us that exceed these limits.  

Our liability policy is an “occurrence” based policy. Thus, our policy is complete when we purchased it and following cancellation of the 
policy it continues to provide coverage for future claims based on conduct that took place during the policy term. However, our insurance may 
not protect us against liability because our policies typically have various exceptions to the claims covered and also require us to assume some 
costs of the claim even though a portion of the claim may be covered. In addition, if we expand into new markets, we may not be aware of the 
need for, or be able to obtain insurance coverage for such activities or, if insurance is obtained, the dollar amount of any liabilities incurred could 
exceed our insurance coverage. A partially or completely uninsured claim, if successful and of significant magnitude, could have a material 
adverse effect on our business, financial condition and results of operations.  

Complying with certain regulations that apply to shipments using our products can limit our activities and increase our cost of operations. 

Shipments using our products and services are subject to various regulations in the countries in which we operate. For example, shipments 

using our products may be required to comply with the shipping requirements promulgated by the Centers for Disease Control (“CDC”), the 
Occupational Safety and Health Organization (“OSHA”), the Department of Transportation (“DOT”) as well as rules established by the 
International Air Transportation Association (“IATA”) and the International Civil Aviation Organization (“ICAO”). Additionally, our data 
logger may be subject to regulation and certification by the Food and Drug Administration (“FDA”), Federal Communications Commission 
(“FCC”), and Federal Aviation Administration (“FAA”). We will need to ensure that our products and services comply with relevant rules and 
regulations to make our products and services marketable, and in some cases compliance is difficult to determine. Significant changes in such 
regulations could require costly changes to our products and services or prevent use of our shippers for an extended period of time while we seek 
to comply with changed regulations. If we are unable to comply with any of these rule or regulations or fail to obtain any required approvals, our 
ability to market our products and services may be adversely affected. In addition, even if we are able to comply with these rules and regulations, 
compliance can result in increased costs. In either event, our financial results and condition may be adversely affected. We depend on our 
business partners and unrelated and frequently unknown third party agents in foreign countries to act on our behalf to complete the importation 
process and to make delivery of our shippers to the final user. The failure of these third parties to perform their duties could result in damage to 
the contents of the shipper resulting in customer dissatisfaction or liability to us, even if we are not at fault.  

If we cannot compete effectively, we will lose business.  

Our products, services and solutions are positioned to be competitive in the cold-chain shipping market. While there are technological and 

marketing barriers to entry, we cannot guarantee that the barriers we are capable of producing will be sufficient to defend the market share we 
wish to gain against current and future competitors. The principal competitive factors in this market include:  

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   acceptance of our business model and a per use consolidated fee structure;  
   ongoing development of enhanced technical features and benefits;  
   reductions in the manufacturing cost of competitors’ products;  
   the ability to maintain and expand distribution channels;  
   brand name;  
   the ability to deliver our products to our customers when requested;  
   the timing of introductions of new products and services; and  
   financial resources.  

Current and prospective competitors have substantially greater resources, more customers, longer operating histories, greater name 
recognition and more established relationships in the industry. As a result, these competitors may be able to develop and expand their networks 
and product offerings more quickly, devote greater resources to the marketing and sale of their products and adopt more aggressive pricing 
policies. In addition, these competitors have entered and will likely continue to enter into business relationships to provide additional products 
competitive to those we provide or plan to provide.  

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We may not be able to compete with our competitors in the industry because many of them have greater resources than we do.  

We expect to continue to experience significant and increasing levels of competition in the future. In addition, there may be other 

companies which are currently developing competitive products and services or which may in the future develop technologies and products that 
are comparable, superior or less costly than our own. For example, some cryogenic equipment manufacturers with greater resources currently 
have solutions for storing and transporting cryogenic liquid and gasses and may develop storage solutions that compete with our products. 
Additionally, some specialty couriers with greater resources currently provide dry ice transportation and may develop other products in the 
future, both of which compete with our products. A competitor that has greater resources than us may be able to bring its product to market faster 
than we can and offer its product at a lower price than us to establish market share. We may not be able to successfully compete with a 
competitor that has greater resources and such competition may adversely affect our business.  

Risks Relating to Our Current Financing Arrangements  

Certain provisions in our existing financing agreements have and may continue to make it more difficult for us to raise capital.  

In connection with our issuance of convertible debentures in October 2007 and May 2008, we executed securities purchase agreements 
pursuant to which such debentures were issued. Pursuant to such securities purchase agreements, for so long as the holders of the debentures 
own any securities of the Company acquired in connection with the securities purchase agreements (such as warrants issued in connection 
therewith), we may not enter into Variable Rate Transactions (as defined in the debentures) without the consent of the holders of the debentures. 
A Variable Rate Transaction includes transactions in which we issue or sell any equity securities that are convertible into, exchangeable or 
exercisable for, or include the right to receive additional shares of our common stock at a conversion, exercise or exchangeable rate or other 
price that is based upon and/or varies with the trading prices of or quotations for the shares of our common stock at any time after the initial 
issuance of such equity securities. This negative covenant, unless waived, has and may continue to make it more difficult to accomplish capital 
raising transactions.  

Certain of our existing stockholders own and have the right to acquire a substantial number of shares of common stock.  

As of June 19, 2012, our directors, executive officers and beneficial owners of 5% or more of our outstanding common stock beneficially 

owned 9,799,261 shares of common stock (without regard to beneficial ownership limitations contained in certain warrants) assuming their 
exercise of all outstanding warrants, options and conversion of all convertible debt; or approximately 21.7% of our outstanding common stock. 
Of these shares of common stock, 3,377,768 shares, or approximately 8.3% of our common stock, will be beneficially owned by CNH Partners, 
LLC, 2,455,549 shares, or approximately 6.1% of our outstanding common stock, will be beneficially owned by Emergent Financial Group and 
3,636,364, or approximately 9.2% of our outstanding common stock will be beneficially owned by James E. Flynn (each calculated without 
regard to the shares of common stock that may be acquired by the other upon the exercise of its warrants and conversion of debt). As such, the 
concentration of beneficial ownership of our common stock may have the effect of delaying or preventing a change in control of CryoPort and 
may adversely affect the voting or other rights of other holders of our common stock.  

Our stock and warrant price is and will continue to be volatile.  

The market price of our common stock has been and, along with the warrants is likely to be, highly volatile and could fluctuate widely in 

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price in response to various factors, many of which are beyond our control, including, but not limited to:  
   technological innovations or new products and services by us or our competitors;  
   additions or departures of key personnel;  
   sales of our common stock;  
   our ability to integrate operations, technology, products and services;  
   our ability to execute our business plan;  
   operating results below expectations;  
   loss of any strategic relationship;  
   industry developments;  

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   economic and other external factors; and  
   period-to-period fluctuations in our financial results.  

You may consider any one of these factors to be material. The price of our common stock and warrants may fluctuate widely as a result of 
any of the above listed factors. In addition, the securities markets have from time to time experienced significant price and volume fluctuations 
that are unrelated to the operating performance of particular companies. These market fluctuations may also materially and adversely affect the 
market price of our common stock and warrants.  

If equity research analysts do not publish research or reports about our business or if they issue unfavorable commentary or downgrade 
our common stock and warrants, the price of our common stock and warrants could decline.  

The trading market for our common stock and warrants relies in part on the research and reports that equity research analysts publish about 

us and our business. We do not control these analysts. The price of our common stock and warrants could decline if one or more equity analyst 
downgrades our stock or if analysts issue other unfavorable commentary or cease publishing reports about us or our business.  

We have not paid dividends on our common stock in the past and do not expect to pay dividends in the foreseeable future. Any return on 
investment may be limited to the value of our common stock.  

We have never paid cash dividends on our common stock and do not anticipate paying cash dividends in the foreseeable future. The 
payment of dividends on our common stock will depend on our earnings, financial condition and other business and economic factors affecting 
us at such time as the Board of Directors may consider the payment of any such dividends. In addition, we may not pay any dividends without 
obtaining the prior consent of the holders of our Debentures. If we do not pay dividends, our common stock may be less valuable because a 
return on your investment will only occur if the price of our common stock appreciates.  

We may need additional capital, and the sale of additional shares of common stock or other equity securities could result in additional 
dilution to our stockholders.  

We believe that our current cash and cash equivalents and anticipated cash flow from operations will be sufficient to meet our anticipated 

cash needs through the fourth quarter of our fiscal year 2013. We may, however, require additional cash resources due to changed business 
conditions or other future developments, including any investments or acquisitions we may decide to pursue. If our resources are insufficient to 
satisfy our cash requirements, we may seek to sell additional equity or debt securities or obtain a credit facility. The sale of additional equity 
securities, or debt securities convertible into equity securities, could result in additional dilution to our stockholders. The incurrence of 
indebtedness would result in increased debt service obligations and could result in operating and financing covenants that would restrict our 
operations.  

Our Articles of Incorporation allows our Board of Directors to issue up to 2,500,000 shares of “blank check” preferred stock.  

Our Articles of Incorporation allows our Board of Directors to issue up to 2,500,000 shares of “blank check” preferred stock, without 

action by our stockholders. Such shares of preferred stock may be issued on terms determined by our Board of Directors, and may have rights, 
privileges and preferences superior to those of our common stock. Without limiting the foregoing, (i) such shares of preferred stock could have 
liquidation rights that are senior to the liquidation preference applicable to our common stock, (ii) such shares of preferred stock could have 
voting or conversion rights, which could adversely affect the voting power of the holders of our common stock and (iii) the ownership interest of 
holders of our common stock will be diluted following the issuance of any such shares of preferred stock. In addition the issuance of such shares 
of blank check preferred stock could have the effect of discouraging, delaying or preventing a change of control of our company.  

Provisions in our bylaws and Nevada law might discourage, delay or prevent a change of control of our company or changes in our 
management and, as a result, may depress the trading price of our common stock.  

Provisions of our bylaws and Nevada law may discourage, delay or prevent a merger, acquisition or other change in control that 
stockholders may consider favorable, including transactions in which you might otherwise receive a premium for your shares of our common 
stock. The relevant bylaw provisions may also prevent or frustrate attempts by our stockholders to replace or remove our management. These 
provisions include advance notice requirements for stockholder proposals and nominations, and the ability of our Board of Directors to make, 
alter or repeal our bylaws.  

Absent approval of our Board of Directors, our bylaws may only be amended or repealed by the affirmative vote of the holders of at least a 

majority of our outstanding shares of capital stock entitled to vote.  

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In addition, Section 78.438 of the Nevada Revised Statutes prohibits a publicly-held Nevada corporation from engaging in a business 

combination with an interested stockholder (generally defined as a person which together with its affiliates owns, or within the last three years 
has owned, 10% of our voting stock, for a period of three years after the date of the transaction in which the person became an interested 
stockholder) unless the business combination is approved in a prescribed manner.  

The existence of the foregoing provisions and other potential anti-takeover measures could limit the price that investors might be willing to 
pay in the future for shares of our common stock. They could also deter potential acquirers of our company, thereby reducing the likelihood that 
you could receive a premium for your common stock in an acquisition.  

Even though we are not incorporated in California, we may become subject to a number of provisions of the California General 
Corporation Law.  

Section 2115(b) of the California Corporations Code imposes certain requirements of California corporate law on corporations organized 
outside California that, in general, are doing more than 50% of their business in California and have more than 50% of their outstanding voting 
securities held of record by persons residing in California. While we are not currently subject to Section 2115(b), we may become subject to it in 
the future.  

The following summarizes some of the principal differences which would apply if we become subject to Section 2115(b).  

Under both Nevada and California law, cumulative voting for the election of directors is permitted. However, under Nevada law 

cumulative voting must be expressly authorized in the Articles of Incorporation and our Amended and Restated Articles of Incorporation do not 
authorize cumulative voting. If we become subject to Section 2115(b), we may be required to permit cumulative voting if any stockholder 
properly requests to cumulate his or her votes.  

Under Nevada law, directors may be removed by the stockholders only by the vote of two-thirds of the voting power of the issued and 
outstanding stock entitled to vote. However, California law permits the removal of directors by the vote of only a majority of the outstanding 
shares entitled to vote. If we become subject to Section 2115(b), the removal of a director may be accomplished by a majority vote, rather than a 
vote of two-thirds, of the stockholders entitled to vote.  

Under California law, the corporation must take certain steps to be allowed to provide for greater indemnification of its officers and 
directors than is provided in the California Corporation Code. If we become subject to Section 2115(b), our ability to indemnify our officers and 
directors, to the extent permitted in our Articles of Incorporation, Bylaws and under Nevada law, may be limited by California law.  

Nevada law permits distributions to stockholders as long as, after the distribution, (i) the corporation would be able to pay its debts as they 
become due and (ii) the corporation’s total assets are at least equal to its liabilities and preferential dissolution obligations. Under California law, 
distributions may be made to stockholders as long as the corporation would be able to pay its debts as they mature and either (i) the corporation’s 
retained earnings equals or exceeds the amount of the proposed distributions, or (ii) after the distributions, the corporation’s tangible assets are at 
least 125% of its liabilities and the corporation’s current assets are at least equal to its current liabilities (or, 125% of its current liabilities if the 
corporation’s average operating income for the two most recently completed fiscal years was less than the average of the interest expense of the 
corporation for those fiscal years). If we become subject to Section 2115(b), we will have to satisfy more stringent financial requirements to be 
able to pay dividends to our stockholders. Additionally, stockholders may be liable to the corporation if we pay dividends in violation of 
California law.  

California law permits a corporation to provide “supermajority vote” provisions in its Articles of Incorporation, which would require 
specific actions to obtain greater than a majority of the votes, but not more than 66  /  percent. Nevada law does not permit supermajority vote 
provisions. If we become subject to Section 2115(b), it is possible that our stockholders would vote to amend our Articles of Incorporation and 
require a supermajority vote for us to take specific actions.  

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Under California law, in a disposition of substantially of all the corporation’s assets, if the acquiring party is in control of or under common 
control with the disposing corporation, the principal terms of the sale must be approved by 90 percent of the stockholders. Although Nevada law 
does contain certain rules governing interested stockholder business combinations, it does not require similar stockholder approval. If we 
become subject to Section 2115(b), we may have to obtain the vote of a greater percentage of the stockholders to approve a sale of our assets to a 
party that is in control of, or under common control with, us.  

California law places certain additional approval rights in connection with a merger if all of the shares of each class or series of a 

corporation are not treated equally or if the surviving or parent party to a merger represents more than 50 percent of the voting power of the other 
corporation prior to the merger. Nevada law does not require such approval. If we become subject to Section 2115(b), we may have to obtain a 
the vote of a greater percentage of the stockholders to approve a merger that treats shares of a class or series differently or where a surviving or 
parent party to the merger represents more than 50% of the voting power of the other corporation prior to the merger.  

California law requires the vote of each class to approve a reorganization or a conversion of a corporation into another entity. Nevada law 
does not require a separate vote for each class. If we become subject to Section 2115(b), we may have to obtain the approval of each class if we 
desire to reorganize or convert into another type of entity.  

California law provides greater dissenters’ rights to stockholders than Nevada law. If we become subject to Section 2115(b), more 

stockholders may be entitled to dissenters’ rights, which may limit our ability to merge with another entity or reorganize.  

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Our stock is deemed to be penny stock.  

Our stock is currently traded on the OTCQB, operated by the OTC Markets Group, Inc., and is subject to the “penny stock rules” adopted 
pursuant to Section 15(g) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). The penny stock rules apply to companies 
not listed on a national exchange whose common stock trades at less than $5.00 per share or which have tangible net worth of less than 
$5,000,000 ($2,000,000 if the company has been operating for three or more years). Such rules require, among other things, that brokers who 
trade “penny stock” to persons other than “established customers” complete certain documentation, make suitability inquiries of investors and 
provide investors with certain information concerning trading in the security, including a risk disclosure document and quote information under 
certain circumstances. Penny stocks sold in violation of the applicable rules may entitle the buyer of the stock to rescind the sale and receive a 
full refund from the broker.  

Many brokers have decided not to trade “penny stock” because of the requirements of the penny stock rules and, as a result, the number of 
broker-dealers willing to act as market makers in such securities is limited. In the event that we remain subject to the “penny stock rules” for any 
significant period, there may develop an adverse impact on the market, if any, for our securities. Because our securities are subject to the “penny 
stock rules,” investors will find it more difficult to dispose of our securities. Further, for companies whose securities are traded in the OTC 
Bulletin Board, it is more difficult: (i) to obtain accurate quotations, (ii) to obtain coverage for significant news events because major wire 
services, such as the Dow Jones News Service, generally do not publish press releases about such companies, and (iii) to obtain needed capital.  

If we fail to maintain effective internal controls over financial reporting, the price of our common stock may be adversely affected.  

Our internal controls over financial reporting may have weaknesses and conditions that could require correction or remediation, the 
disclosure of which may have an adverse impact on the price of our common stock. We are required to establish and maintain appropriate 
internal controls over financial reporting. Failure to establish those controls (or any failure of those controls once established) could adversely 
impact our public disclosures regarding our business, financial condition or results of operations. In addition, management’s assessment of 
internal controls over financial reporting may identify weaknesses and conditions that need to be addressed in our internal controls over financial 
reporting or other matters that may raise concerns for investors. Any actual or perceived weaknesses and conditions that need to be addressed in 
our internal control over financial reporting and disclosure of management’s assessment of our internal controls over financial reporting may 
have an adverse impact on the price of our common stock.  

Standards for compliance with Section 404 of the Sarbanes-Oxley Act of 2002 are uncertain, and if we fail to comply in a timely manner, 
our business could be harmed and our stock price could decline.  

Rules adopted by the SEC pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 require an annual assessment of our internal controls 

over financial reporting. The standards that must be met for management to assess the internal controls over financial reporting as effective are 
evolving and complex, and require significant documentation, testing, and possible remediation to meet the detailed standards. We expect to 
continue to incur significant expenses and to devote resources to continued Section 404 compliance on an ongoing basis. It is difficult for us to 
predict how long it will take or how costly it will be to complete the assessment of the effectiveness of our internal controls over financial 
reporting and to remediate any deficiencies in our internal controls. As a result, we may not be able to complete the assessment and remediation 
process on a timely basis. In the event that our Principal Executive Officer or Chief Financial Officer determine that our internal controls over 
financial reporting are not effective as defined under Section 404, we cannot predict how regulators will react or how the market price of our 
common stock will be affected; however, we believe that there is a risk that investor confidence and share value may be negatively impacted.  

If we fail to remain current in our reporting requirements, our securities could be removed from the OTC Bulletin Board, which would 
limit the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in the secondary market.  

Companies trading on the OTCQB must be reporting issuers under Section 12 of the Exchange Act, and must be current in their reports 

under Section 13, in order to maintain price quotation privileges on the OTC Bulletin Board. If we fail to remain current on our reporting 
requirements, we could be removed from the OTC Bulletin Board. As a result, the market liquidity for our securities could be severely adversely 
affected by limiting the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in the secondary 
market.  

ITEM 1B.  UNRESOLVED STAFF COMMENTS 

Not applicable.  

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ITEM 2. 

PROPERTIES 

We do not own real property. We currently lease two facilities, with approximately 12,000 square feet of corporate, research and 

development, and warehouse facilities, located in Lake Forest, California (“Lake Forest Facility”) and approximately 4,100 square feet of 
corporate offices located in San Diego, California (“San Diego Facility”). In June 2010, the Company entered into a third amendment to the 
Lake Forest Facility lease and extended the lease for sixty months commencing July 1, 2010 with a right to cancel the lease with a minimum of 
120 day written notice at any time after December 31, 2012. On November 28, 2011, the Company entered into a lease agreement for the 
corporate offices in San Diego for a thirty six month period ending December 31, 2014.  

The Company currently makes base lease payments of approximately $16,000 per month, due at the beginning of each month. We believe 
that these facilities are adequate, suitable and of sufficient capacity to support our immediate needs. Additional space may be required, however, 
as we expand our research and development, manufacturing and selling and marketing activities.  

ITEM 3. 

LEGAL PROCEEDINGS 

In the ordinary course of business, we are at times subject to various legal proceedings and disputes, including product liability claims. We 

currently are not aware of any such legal proceedings or claim that we believe will have, individually or in the aggregate, a material adverse 
effect on our business, operating results or cash flows. It is our practice to accrue for open claims based on our historical experience and 
available insurance coverage.  

ITEM 4.  MINE SAFETY DISCLOSURES 

Not applicable.  

PART II  

ITEM 5.  MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDERS’ MATTERS AND ISSUER 

PURCHASES OF EQUITY SECURITIES 

Market Information  

(a) Market Information. Presently, our common stock is quoted on the OTCQB, operated by the OTC Markets Group, Inc. under the 
symbol CYRX. On June 19, 2012, the last reported sale of our common stock was $0.58. The following table shows the high and low sales price 
of our common stock for the two fiscal years ended March 31, 2012 and 2011.  

Fiscal Year 2012  
Quarter Ended March 31, 2012  
Quarter Ended December 31, 2011  
Quarter Ended September 30, 2011  
Quarter Ended June 30, 2011  
Fiscal Year 2011  
Quarter Ended March 31, 2011  
Quarter Ended December 31, 2010  
Quarter Ended September 30, 2010  
Quarter Ended June 30, 2010  

Common Stock  
Sales Price 

High        

Low    

$ 0.90       
$ 1.24       
$ 1.73       
$ 1.60       

$ 1.69       
$ 0.95       
$ 1.50       
$ 2.20       

$ 0.60    
$ 0.65    
$ 0.96    
$ 0.85    

$ 0.51    
$ 0.43    
$ 0.66    
$ 1.31    

(b) Holders. As of June 19, 2012, the number of stockholders of record of the Company’s common stock was 202.  

(c) Dividends. No dividends on common stock have been declared or paid by the Company. The Company intends to employ all available 

funds for the development of its business and, accordingly, does not intend to pay any cash dividends in the foreseeable future.  

(d) Securities Authorized for Issuance Under Equity Compensation. The information included under Item 12 of Part III of this Annual 

Report is hereby incorporated by reference into this Item 5 of Part II of this Annual Report.  

(e) Recent Sale of Unregistered Securities . The following is a summary of transactions by the Company during the past quarter involving 
the issuance and sale of the Company’s securities that were not registered under the Securities Act of 1933, as amended (the “Securities Act”). 
All securities sold by the Company were sold to individuals, trusts or others who were accredited investors as defined under Regulation D under 
the Securities Act, as amended.  

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In February and March 2012, the Company conducted a private placement of units totaling 9,477,554 at a purchase price of $0.55 per unit 
(the “February 2012 Private Placement”) for total proceeds of $4,640,400, net of offering costs of $572,255. Each unit consisted of one share of 
common stock and one warrant to purchase one share of common stock at an exercise price of $0.69 per share. Each warrant is fully exercisable 
six months from the date of issuance for a period of five years from the date of issuance. All units were purchased by accredited or institutional 
investors under three closings; first closing of 6,795,572 units on February 22, 2012, second closing of 2,032,937 units on February 28, 2012 and 
a third closing of 649,045 units on March 7, 2012.  

Craig-Hallum Capital Group LLC acted as the lead placement agent, and Emergent Financial Group, Inc. and Maxim Group LLC served as 

co-placement agents in this transaction and received, in the aggregate, commissions of $450,245, plus reimbursement of out-of-pocket expenses 
of $43,530, and 248,375 warrants to purchase shares of the Company’s common stock at an exercise price of $0.69 per share. The warrants have 
terms identical to the warrants issued to the investors in the February 2012 Private Placement. The fair value of the warrants issued to the 
placement agents of $152,579 was based on Black-Scholes and was recorded to additional paid-in capital and offset against the proceeds of the 
financing with no net effect on equity. The Company also incurred $78,480 of issuance costs including legal, accounting and printer fees related 
to this transaction. The placement agent expenses and issuance costs have been offset against the proceeds of the financing.  

Because the consummation of the February 2012 Private Placement would have triggered defaults under the Company’s October 2007 
Debentures, prior to the initial close of the February 2012 Private Placement, the Company obtained a waiver from the holders of the October 
2007 Debentures with respect to such defaults and their consent to the February 2012 Private Placement. In consideration for such waiver and 
consent, the Company, at the initial close, issued to the holders of the October 2007 Debentures warrants to purchase an aggregate of 280,000 
shares of the Company’s common stock at an exercise price of $0.69 per share. The warrants have terms identical to the warrants issued to the 
investors in the February 2012 Private Placement. The fair value of the warrants issued to the convertible debenture holders of $156,999 was 
based on Black-Scholes and was recorded to additional paid-in capital and interest expense in the accompanying consolidated statement of 
operations.  

ITEM 6. 

SELECTED FINANCIAL DATA 

The following selected financial data has been derived from audited consolidated financial statements of the Company for each of the five 

years in the period ended March 31, 2012. These selected financial summaries should be read in conjunction with the financial information 
contained for each of the two years in the period ended March 31, 2012, included in the consolidated financial statements and notes thereto, 
Management’s Discussion and Analysis of Results of Operations and Financial Condition, and other information provided elsewhere herein.  

Years Ended March 31,  
(in thousands, except per share data)  

2012 

2011 

2010 

2009 

2008 

Consolidated Statement of Operations Data:  
Revenues  
Cost of revenues  
Gross loss  

Selling, general and administrative  
Research and development  
Total operating expenses  

Loss from operations  
Other (expense) income:  
Interest income  
Interest expense  
Loss on sale of fixed assets  
Loss on extinguishment of debt  
Change in fair value of derivative liabilities  

Net loss before income taxes  
Income taxes  
Net loss  
Net loss per common share, basic and diluted  
Weighted average shares used in computing net loss per common share, basic and 

diluted  

556       $ 

476       $  118       $ 

    $ 
       1,392      
(836 )    
       6,106      
492      
       6,598      
       (7,434 )    

   1,303      
(827 )    
   4,321      
449      
   4,770      
   (5,597 )    

718      
(600 )    
   3,313      
284      
   3,597      
  (4,197 )    

35       $ 
546      
(511 )    
   2,387      
297      
   2,684      
   (3,195 )    

84    
386    
(302 )  
   2,551    
166    
   2,717    
  (3.019 )  

16      
(619 )    
   —        
   —        
50      
   (6,150 )    
2      

12      
(528 )    
       —        
       —        
119      
       (7,831 )    
2      

50    
  (1,593 )  
   —      
   —      
   —      
  (4,562 )  
2    
    $ (7,833 )     $ (6,152 )     $ (5,652 )     $ (16,705 )     $ (4,564 )  
(4.05 )     $  (1.16 )  
    $  (0.27 )     $  (0.46 )     $  (1.13 )     $ 

32      
   (2,693 )    
   —        
  (10,847 )    
   —        
  (16,703 )    
2      

8      
  (7,029 )    
(9 )    
   —        
   5,577      
  (5,650 )    
2      

      28,975      

  13,302      

   5,011      

   4,124      

   3,943    

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Consolidated Balance Sheet Data:  
Cash, cash equivalents  
Working capital (deficit)  
Total assets  
Convertible notes, net  
Other long-term obligations  
Accumulated deficit  
Total stockholders’ equity (deficit)  

As of March 31,  
(in thousands)  

2012 

2011 

2010 

2009 

2008 

$  4,618      
   4,024      
   6,214      
338      
   1,375      
  (59,929 )    
   3,730      

$  9,278      
   6,760      
   11,031      
   2,401      
   1,423      
  (52,096 )    
   5,948      

$  3,630      
   1,995      
   4,777      
   2,502      
   1,478      
  (45,944 )    
(915 )    

250      
$ 
   (3,693 )    
   1,573      
   3,883      
   1,601      
  (30,634 )    
   (4,776 )    

$  2,231    
981    
   3,461    
902    
   1,711    
  (13,929 )  
   —      

ITEM 7.  MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS 

This Annual Report on Form 10-K contains forward-looking statements that have been made pursuant to the provisions of the Private 

Securities Litigation Reform Act of 1995 and concern matters that involve risks and uncertainties that could cause actual results to differ 
materially from those projected in the forward-looking statements. Discussions containing forward-looking statements may be found in the 
material set forth under “Business,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and in other 
sections of this Form 10-K. Words such as “may,” “will,” “should,” “could,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” 
“potential,” “continue” or similar words are intended to identify forward-looking statements, although not all forward-looking statements contain 
these words. Although we believe that our opinions and expectations reflected in the forward-looking statements are reasonable as of the date of 
this Annual Report on Form 10-K, we cannot guarantee future results, levels of activity, performance or achievements, and our actual results 
may differ substantially from the views and expectations set forth in this Annual Report on Form 10-K. We expressly disclaim any intent or 
obligation to update any forward-looking statements after the date hereof to conform such statements to actual results or to changes in our 
opinions or expectations. Readers are urged to carefully review and consider the various disclosures made by us, which attempt to advise 
interested parties of the risks, uncertainties, and other factors that affect our business, set forth in detail in Item 1A of Part I, under the heading 
“Risk Factors.”  

The following discussion and analysis should be read in conjunction with our consolidated financial statements and the related notes to 

those statements contained elsewhere in this Annual Report on Form 10-K.  

General Overview  

We are a provider of an innovative cold chain frozen shipping system dedicated to providing superior, affordable cryogenic shipping 
solutions that ensure the stable transportation temperature, of high value, temperature sensitive materials. We have developed cost effective 
reusable cryogenic transport containers (referred to as a “shipper”) capable of transporting biological, environmental and other temperature 
sensitive materials at temperatures below minus 150° Celsius. These dry vapor shippers are one of the first significant alternatives to dry ice 
shipping and achieve 10-plus day holding times compared to one to two day holding times with dry ice.  

Our value proposition comes from providing both stable temperatures during transportation and an environmentally friendly, long lasting 

shipper, and through our value added monitoring of transportation services that offer a simple, hassle-free solution for our customers. These 
value-added services include an internet-based web portal that enables the customer to initiate scheduling, shipping and tracking of the progress 
and status of a shipment, and provides in-transit temperature and custody transfer monitoring services of the shipper. The CryoPort service also 
provides a fully ready charged shipper containing all freight bills, customs documents and regulatory paperwork for the entire journey of the 
shipper to our customers at their pick up location.  

Our principal focus has been the commercialization of our solution as well as the further development of our CryoPort Express  Portal, an 

® 

® 

innovative IT solution for shipping and tracking high-value specimens through overnight shipping companies and specialty couriers, and our 
CryoPort Express  Shippers, a dry vapor cryogenic shipper for the transport of biological and pharmaceutical materials. A dry vapor cryogenic 
shipper is a container that uses liquid nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide 
stable storage temperatures below minus 150° Celsius. The dry vapor shipper is designed using innovative, proprietary, and patented technology 
which prevents spillage of liquid nitrogen and pressure build up as the liquid nitrogen evaporates. A proprietary retention system is employed to 
ensure that liquid nitrogen is retained inside the vacuum container, even when placed upside-down or on its side, as is often the case when in the 
custody of a shipping company. Biological specimens are stored in a specimen chamber, referred to as a “well,” inside the container and 
refrigeration is provided by non-hazardous cold nitrogen gas evolving from the liquid nitrogen entrapped within the retention system 
surrounding the well. Biological specimens transported using our cryogenic shipper can include clinical samples, diagnostics, live cell 
pharmaceutical products (such as cancer vaccines, semen and embryos, infectious substances) and other items that require and/or are protected 
through continuous exposure to frozen or cryogenic temperatures.  

We offer our solution to companies in the life sciences industry. These companies operate within a heavily regulated environment and as 

such, changing vendors and distribution practices typically require a number of steps which may include the audit of our facilities, review of our 
procedures, qualifying us as a vendor, and performing test shipments. This process can take several months or longer to complete prior to a 
company fully adopting the Cryoport Express solution.  

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During our early years, our limited revenue was derived from the sale of our reusable product line. Our current business plan focuses on 

per- use leasing of the shipping container and added-value services that will be used by us to provide an end-to-end and cost-optimized shipping 
solution to life science companies moving pharmaceutical and biological samples in clinical trials and pharmaceutical distribution.  

We have incurred losses since inception and had an accumulated deficit of $59,929,015 through March 31, 2012.  

Going Concern  

As reported in the Report of Independent Registered Public Accounting Firm to our March 31, 2012 and 2011 consolidated financial 
statements, we have incurred recurring losses and negative cash flows from operations since inception. These factors, among others, raise 
substantial doubt about our ability to continue as a going concern.  

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There are significant uncertainties which may negatively affect our operations. These are principally related to (i) the expected ramp up of 

® 

revenues of the new CryoPort Express  System, (ii) the absence of any commitment or firm orders from key customers in our target markets, 
(iii) the success in bringing additional products currently under development to market with our key customers, and (iv) risks associated with 
scaling company operations to meet demand. Moreover, there is no assurance as to when, if ever, we will be able to conduct our operations on a 
profitable basis. Our limited historical revenues for our reusable product, limited introductory revenues to date of the CryoPort Express  System 
and the lack of any purchase requirements in our existing distribution agreements, make it impossible to identify any trends in our business 
prospects.  

® 

We have not generated significant revenues from operations and have no assurance of any future revenues. We generated revenues from 

operations of $555,637, incurred a net loss of $7,832,928 and used cash of $6,780,134 in our operating activities during the year ended 
March 31, 2012. We had working capital of $4,024,120, and had cash and cash equivalents of $4,617,535 at March 31, 2012.  

Currently management has projected that cash on hand, including the gross proceeds from our private placement in February and March 
2012, will be sufficient to allow us to continue our operations into the fourth quarter of our fiscal year 2013 until more significant revenues can 
be generated or more funding can be secured. These matters raise substantial doubt about our ability to continue as a going concern.  

Results of Operations  

The following table sets forth, for the periods indicated, certain information derived from our consolidated statements of operations.  

Revenues  
Cost of revenues  
Gross loss  
Cost and expenses:  
Selling, general and administrative  
Research and development  
Total cost and expenses  
Loss from operations  
Other income (expense):  
Interest income  
Interest expense  
Loss on sale of property and equipment  
Change in fair value of derivative liabilities  
Total other expense, net  
Loss before income taxes  
Income taxes  
Net loss  
Net loss available to common stockholders per common 

share:  

Basic and diluted loss per common share  
Weighted average common shares outstanding:  
Basic and diluted  

2012  
(‘000) 

Years Ended March 31, 
2011  
(‘000) 

2010  
(‘000) 

$ 

$ 

$ 

556      
1,392      
(836 )    

6,106      
492      
6,598      
(7,434 )    

12      
(528 )    
—        
119      
397      
(7,831 )    
2      
(7,833 )    

(0.27 )    

$ 

$ 

$ 

476      
1,303      
(827 )    

4,321      
449      
4,770      
(5,597 )    

16      
(619 )    
—        
50      
(553 )    
(6,150 )    
2      
(6,152 )    

$ 

$ 

118    
718    
(600 )  

3,312    
285    
3,597    
(4,197 )  

8    
(7,029 )  
(9 )  
5,577    
(1,453 )  
(5,650 )  
2    
(5,652 )  

(0.46 )    

$ 

(1.13 )  

  28,974,843      

  13,301,769      

  5,011,057    

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Years ended March 31, 2012 and 2011:  

Revenues . Revenues were $555,637 for the year ended March 31, 2012, as compared to $475,504 for the year ended March 31, 2011, 

representing an increase of 16.9%. The number of customers ordering during the year compared to the previous year increased by 145% due to 
the increase in sales force and resulting sales activities as well as an increase in one-time shipments related to in-vitro fertilization procedures in 
the international market. The increase in revenue attributable to the increase in new customers was significantly offset by a decrease in revenue 
derived from one customer (1% in fiscal year 2012 as compared to 36% in the prior year), as one of this customer’s products no longer required 
the cryogenic shipping method during the current period.  

Gross loss and cost of revenues . Gross loss for the year ended March 31, 2012 was 151% of revenues, or $836,823, as compared to 174% 

of revenues, or $827,484, for the prior year. Cost of revenues for the year ended March 31, 2012 was 251% of revenues, or $1,392,460 as 
compared to 274% of revenues, or $1,302,988, for the prior year. The cost of revenues exceeded revenues due to fixed manufacturing costs and 
plant underutilization.  

Selling, general and administrative expenses . Selling, general and administrative expenses were $6,106,006 for the year ended March 31, 
2012, as compared to $4,320,461 for the prior year. The $1,785,545 increase reflects the addition of twelve new employees (ten in the sales and 
marketing department), recruiting fees for these new hires, and consulting costs for promotional activities. The increase in headcount, in 
particular in the sales, marketing and client services department, reflects the Company’s focus on promoting the use of its CryoPort Express 
System and expanding its customer base through a direct inside and field sales team.  

® 

Research and development expenses . Research and development expenses were $491,849 for the year ended March 31, 2012, as compared 
® 

to $449,129 for the prior year. Our research and development efforts are focused on continually improving the features of the CryoPort Express 
System including the web based customer service portal and the CryoPort Express  Shippers.  

® 

Interest expense . Interest expense was $527,753 for the year ended March 31, 2012, as compared to $618,765 for the prior year. Interest 

expense for the year ended March 31, 2012 included the value on warrants issued to convertible debt holders of $156,999, stated interest expense 
on the convertible debt of $122,824, amortization of the debt discount of $197,225, and accrued interest on our related party notes payable of 
$48,036. Interest expense for the prior year included amortization of the debt discount of $522,041, accrued interest on our related party notes 
payable of $57,156 and interest expense on our convertible debentures of $19,233.  

Interest income . Interest income was $11,940 for the year ended March 31, 2012 as compared to $15,571 for the prior year.  

Change in fair value of derivative liabilities . The gain on the change in fair value of derivative liabilities was $119,163 for the year ended 
March 31, 2012, compared to a gain of $49,590 for the prior year. The gain for the year ended March 31, 2012 was the result of a decrease in the 
value of our warrant derivatives, due primarily to a decrease in our stock price.  

Net loss . As a result of the factors described above, net loss for the year ended March 31, 2012 increased by $1,680,650 to $7,832,928 or 
($0.27) per share compared to a net loss of $6,152,278 or ($0.46) per share for the prior year. The decrease of net loss per share compared to the 
prior year is a result of the increase in the weighted average common shares outstanding from 13.3 million to 29.0 million. This increase is 
primarily due to common stock issued in connection with the Company’s private placements in fiscal 2012.  

Liquidity and Capital Resources  

As of March 31, 2012, the Company had cash and cash equivalents of $4,617,535 and working capital of $4,024,120. As of March 31, 

2011, the Company had cash and cash equivalents of $9,278,443 and working capital of $6,759,755. Historically, we have financed our 
operations primarily through sales of our debt and equity securities. From March 2005 through March 2012, we have received net proceeds of 
approximately $32.8 million from sales of our common stock and the issuance of promissory notes, warrants and debt.  

In February and March 2012, the Company conducted a private placement of units totaling 9,477,554 at a purchase price of $0.55 per unit 
(the “February 2012 Private Placement”) for total proceeds of $4,640,400, net of offering costs of $572,255. Each unit consisted of one share of 
common stock and one warrant to purchase one share of common stock at an exercise price of $0.69 per share. Each warrant is fully exercisable 
six months from the date of issuance for a period of five years from the date of issuance.  

For the year ended March 31, 2012, we used $6,780,134 of cash for operations primarily as a result of the net loss of $7,832,928 including 

non-cash expenses of $717,090 for the fair value of stock options and warrants. Net operating losses increased as a result of an increase in 
headcount and overall commercial activity.  

Net cash used in investing activities totaled $388,061 during the year ended March 31, 2012, and was attributable to the purchase of 

property and equipment of $262,641 and the purchase of intangible assets of $125,420.  

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Net cash provided by financing activities totaled $2,507,287 during the year ended March 31, 2012, and resulted primarily from net 
proceeds received from the private placement completed during the fourth quarter of fiscal 2012 in the amount of $4,640,400 and cash exercises 
of warrants in the amount of $571,630. This was partially offset by the repayment of the convertible debentures in the amount of $2,273,028, the 
transfer of $251,368 into escrow in conjunction with the private placement representing the total future principal payments due to one of the 
convertible debenture holders and the payment of deferred financing costs of $158,270.  

As discussed in Note 1 of the accompanying consolidated financial statements, there exists substantial doubt regarding the Company’s 
ability to continue as a going concern. As discussed above, the Company completed a private placement in March of 2012. The funds raised will 
be used for working capital purposes and to continue our sales efforts to advance the Company’s commercialization of the CryoPort Express 
Solution. Management has estimated that cash on hand as of March 31, 2012 and forecasted sales will be sufficient to allow the Company to 
continue its operations through the end of fiscal 2013. However, the Company’s management recognizes that the Company may need to obtain 
additional capital, if forecasted sales targets are not met. Management’s plans to extend the cash runway include a reduction in non-sales 
generating expenses and the use of third parties for services such as its recycling and refurbishment centers. This will provide for greater 
flexibility in aligning operational expenses with the sales ramp. Such plans also may include obtaining additional capital through equity and/or 
debt funding sources; however, no assurance can be given that additional capital, if needed, will be available when required or upon terms 
acceptable to the Company.  

® 

Contractual Obligations  

The following table summarizes our contractual obligations as of March 31, 2012, and the effects such obligations are expected to have on 

liquidity and cash flow in future periods (in thousands):  

Operating Lease Obligations  
Convertible Debentures  
Other Long-term Debt Obligations  
Total  

Payments Due by Period 

Total        
$  620       
   347       
  1,471       
$ 2,438       

Less than 1 
Year 

$ 

$ 

187       
347       
96       
630       

1-3 Years       
$  433       
   —         
   1,375       
$ 1,808       

3-5 Years       
$  —         
   —         
   —         
$  —         

More than 
5 Years    
$  —      
   —      
   —      
$  —      

Impact of Inflation . From time to time, CryoPort experiences price increases from third party manufacturers and these increases cannot 

always be passed on to CryoPort’s customers. While these price increases have not had a material impact on CryoPort’s historical operations or 
profitability in the past, they could affect revenues in the future.  

Critical Accounting Policies and Estimates  

Management’s discussion and analysis of financial condition and results of operations, as well as disclosures included elsewhere in this 
Annual Report, are based upon our consolidated financial statements, which have been prepared in accordance with U.S. generally accepted 
accounting principles. Our significant accounting policies are described in the notes to the audited consolidated financial statements contained 
elsewhere in this Annual Report. Included within these policies are our “critical accounting policies.” Critical accounting policies are those 
policies that are most important to the preparation of our consolidated financial statements and require management’s most subjective and 
complex judgment due to the need to make estimates about matters that are inherently uncertain. Although we believe that our estimates and 
assumptions are reasonable, actual results may differ significantly from these estimates. Changes in estimates and assumptions based upon actual 
results may have a material impact on our results of operations and/or financial condition.  

We believe that the critical accounting policies that most impact the consolidated financial statements are as described below.  

Revenue Recognition  

Per Use Revenues  

We recognize revenues from product sales when there is persuasive evidence that an arrangement exists, when title has passed, the price is 

fixed or determinable, and we are reasonably assured of collecting the resulting receivable. The Company records a provision for claims based 
upon historical experience. Actual claims in any future period may differ from the Company’s estimates. During its early years, the Company’s 
limited revenue was derived from the sale of our reusable product line. The Company’s current business plan focuses on per-use leasing of the 
shipping container and value-added services that will be used by us to provide an end-to-end and cost-optimized shipping solution.  

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The Company provides shipping containers to their customers and charges a fee in exchange for the use of the container. The Company’ 

arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a period of time. The 
Company retains title to the containers and provides its customers the use of the container for a specified shipping cycle. At the culmination of 
the customer’s shipping cycle, the container is returned to the Company. As a result of our new business plan, during the quarter ended 
September 30, 2009, the Company reclassified the containers from inventory to fixed assets upon commencement of the loaned-container 
program.  

Inventory  

The Company writes down its inventories for estimated obsolescence or unmarketable inventory equal to the difference between the cost of 

inventory and the estimated market value based upon assumptions about future demand, future pricing and market conditions. Inventory reserve 
costs are subject to estimates made by the Company based on historical experience, inventory quantities, age of inventory and any known 
expectations for product changes. If actual future demands, future pricing or market conditions are less favorable than those projected by 
management, additional inventory write-downs may be required and the differences could be material. Such differences might significantly 
impact cash flows from operating activities. Once established, write-downs are considered permanent adjustments to the cost basis of the 
obsolete or unmarketable inventories.  

During its early years, the Company’s limited revenue was derived from the sale of our reusable product line. The Company’s current 
business plan focuses on per-use leasing of the shipping container and value-added services that will be used by us to provide an end-to-end and 
cost-optimized shipping solution. The Company provides shipping containers to its customers and charges a fee in exchange for the use of the 
container. The Company’ arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a 
period of time. The Company retains title to the containers and provides its customers the use of the container for a specified shipping cycle. At 
the culmination of the customer’s shipping cycle, the container is returned to the Company. As a result of our current business plan, during fiscal 
year 2010, the Company reclassified the containers from inventory to fixed assets upon commencement of the loaned-container program. The 
Company’s current inventory consists of accessories that are sold and shipped to customers along with loaned containers and not returned to the 
Company with the containers at the culmination of the customer’s shipping cycle.  

Property and Equipment  

Property and equipment are stated at cost, net of accumulated depreciation and amortization. Depreciation and amortization of fixed assets 

are provided using the straight-line method over the following useful lives:  

Cryogenic Shippers  
Furniture and fixtures  
Machinery and equipment  
Leasehold improvements  

3 years    
7 years    
5-7 years    
  Lesser of lease term or estimated useful life    

Betterments, renewals and extraordinary repairs that extend the lives of the assets are capitalized; other repairs and maintenance charges 

are expensed as incurred. The cost and related accumulated depreciation and amortization applicable to assets retired are removed from the 
accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets comprise patents and trademarks and software development costs. The Company capitalizes costs of obtaining patents 

and trademarks which are amortized, using the straight-line method over their estimated useful life of five years. The Company capitalizes 
certain costs related to software developed for internal use. Software development costs incurred during the preliminary or maintenance project 
stages are expensed as incurred, while costs incurred during the application development stage are capitalized and amortized using the straight-
line method over the estimated useful life of the software, which is five years. Capitalized costs include purchased materials and costs of services 
including the valuation of warrants issued to consultants.  

Long-Lived Assets  

The Company assesses the recoverability of its long-lived assets by determining whether the depreciation and amortization of long-lived 

assets over their remaining lives can be recovered through projected undiscounted cash flows. The amount of long-lived asset impairment is 
measured based on fair value and is charged to operations in the period in which long-lived asset impairment is determined by management. 
Manufacturing fixed assets are subject to obsolescence potential as result of changes in customer demands, manufacturing process changes and 
changes in materials used. The Company is not currently aware of any such changes that would cause impairment to the value of its 
manufacturing fixed assets.  

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Stock-based Compensation  

We recognize compensation costs for all stock-based awards made to employees and directors. The fair value of stock-based awards is 
estimated at grant date using an option pricing model and the portion that is ultimately expected to vest is recognized as compensation cost over 
the requisite service period.  

We use the Black-Scholes option-pricing model to estimate the fair value of stock-based awards. The determination of fair value using the 

Black-Scholes option-pricing model is affected by our stock price as well as assumptions regarding a number of complex and subjective 
variables, including expected stock price volatility, risk-free interest rate, expected dividends and projected employee stock option exercise 
behaviors. We estimate the expected term based on the contractual term of the awards and employees’ exercise and expected post-vesting 
termination behavior.  

At March 31, 2012, there was $306,600 of total unrecognized compensation cost related to non-vested stock options, which is expected to 

be recognized over a remaining weighted average vesting period of 2.35 years.  

Derivative Liabilities  

Our issued and outstanding common stock purchase warrants and embedded conversion features previously treated as equity pursuant to 
the derivative treatment exemption were no longer afforded equity treatment, and the fair value of these common stock purchase warrants and 
embedded conversion features, some of which have exercise price reset features and some that were issued with convertible debt, from equity to 
liability status as if these warrants were treated as a derivative liability since their date of issue. The common stock purchase warrants were not 
issued with the intent of effectively hedging any future cash flow, fair value of any asset, liability or any net investment in a foreign operation. 
The warrants do not qualify for hedge accounting, and as such, all future changes in the fair value of these warrants will be recognized currently 
in earnings until such time as the warrants are exercised or expire. These common stock purchase warrants do not trade in an active securities 
market, and as such, we estimate the fair value of these warrants using the Black-Scholes option pricing model.  

Convertible Debentures  

If a conversion feature of conventional convertible debt is not accounted for as a derivative instrument and provides for a rate of 

conversion that is below market value, this feature is characterized as a beneficial conversion feature (“BCF”). A BCF is recorded by the 
Company as a debt discount. In those circumstances, the convertible debt will be recorded net of the discount related to the BCF. The Company 
amortizes the discount to interest expense over the life of the debt using the effective interest method.  

Deferred Financing Costs  

Deferred financing costs represent costs incurred in connection with the issuance of the convertible notes payable and private equity 
financing. Deferred financing costs are being amortized over the term of the financing instrument on a straight-line basis, which approximates 
the effective interest method or netted against the gross proceeds received from equity financing.  

Income Taxes  

We account for income taxes under the provision of the Financial Accounting Standards Board (“FASB”) Accounting Standards 

Codification (“ASC”) 740, Income Taxes , or ASC 740. As of March 31, 2012 and 2011, there were no unrecognized tax benefits included in the 
accompanying balance sheets that would, if recognized, affect the effective tax rates. Based on the weight of available evidence, the Company’s 
management has determined that it is more likely than not that the net deferred tax assets will not be realized. Therefore, the Company has 
recorded a full valuation allowance against the net deferred tax assets. The Company’s income tax provision consists of state minimum taxes.  

Our practice is to recognize interest and/or penalties related to income tax matters in income tax expense. We had no accrual for interest or 

penalties on our consolidated balance sheets at March 31, 2012 and 2011, respectively and have not recognized interest and/or penalties in the 
consolidated statement of operations for the year ended March 31, 2012. We are subject to taxation in the United States and various state 
jurisdictions. As of March 31, 2012, the Company is no longer subject to U.S. federal examinations for years before 2008 and for California 
franchise and income tax examinations before 2007. However, to the extent allowed by law, the taxing authorities may have the right to examine 
prior periods where net operating losses were generated and carried forward, and make adjustments up to the amount of the net operating loss 
carry forward amount. The Company is not currently under examination by U.S. federal or state jurisdictions.  

29  

   
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New Accounting Pronouncements  

In June 2011, the FASB updated the accounting guidance on alignment of disclosures for GAAP and the International Financial Reporting 
Standards, or IFRS, by updating Topic 820 entitled “Amendments to Achieve Common Fair Value Measurement and Disclosure Requirements 
in U.S. GAAP and IFRS”, relating to presentation of fair value measurements reported in financial statements. The updated guidance requires 
companies to align fair value measurement and disclosure requirements between GAAP and IFRS. The updated guidance became effective for 
our fiscal 2012 year. The adoption of this guidance did not have a material impact on our financial position or results of operations.  

ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK 

Changes in United States interest rates would affect the interest earned on our cash and cash equivalents and interest expense on our 

revolving credit facility.  

Based on our overall cash and cash equivalents interest rate exposure at March 31, 2012, a near-term change in interest rates, based on 

historical movements, would not have a material adverse effect on our financial position or results of operations.  

We have operated primarily in the United States. Accordingly, we have not had any significant exposure to foreign currency rate 

fluctuations.  

ITEM 8. 

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA 

Reference is made to the consolidated financial statements included in this Report at pages F-3 through F-31.  

ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL 

DISCLOSURES 

None.  

ITEM 9A.  CONTROLS AND PROCEDURES 

(a) Evaluation of Disclosure Controls and Procedures. The term “disclosure controls and procedures” (defined in Rule 13a-15(e) under the 

Securities and Exchange Act of 1934 (the “Exchange Act”) refers to the controls and other procedures of a company that are designed to ensure 
that information required to be disclosed by a company in the reports that it files under the Exchange Act is recorded, processed, summarized 
and reported within the required time periods. Under the supervision and with the participation of our management, including our principal 
executive officer and chief financial officer, we have conducted an evaluation of the effectiveness of the design and operation of our disclosure 
controls and procedures, as of March 31, 2012. Based on this evaluation, our principal executive officer and chief financial officer concluded 
that our disclosure controls and procedures were effective as of March 31, 2012 to ensure the timely disclosure of required information in our 
Securities and Exchange Commission filings.  

Because of inherent limitations, internal control over financial reporting may not prevent or detect misstatements. In addition, the design of 
any system of control is based upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will 
succeed in achieving its stated goals under all future events, no matter how remote. Accordingly, even effective internal control over financial 
reporting can only provide reasonable assurance of achieving their control objectives.  

(b) Management’s Report on Internal Control Over Financial Reporting. Management’s Report on Internal Control Over Financial 

Reporting which appears on the following page is incorporated herein by this reference.  

(c) Changes in Internal Control over Financial Reporting. There have been no changes in our internal control over financial reporting 

during the fourth quarter of the fiscal year ended March 31, 2012 that have materially affected, or are reasonably likely to materially affect, our 
internal control over financial reporting.  

ITEM 9B.  OTHER INFORMATION 

None.  

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CRYOPORT, INC.  
MANAGEMENT’S REPORT ON  
INTERNAL CONTROL OVER FINANCIAL REPORTING  

The management of the Company is responsible for establishing and maintaining effective internal control over financial reporting and for 

the assessment of the effectiveness of internal control over financial reporting. The Company’s internal control over financial reporting is a 
process designed, as defined in Rule 13a-15(f) under the Securities and Exchange Act of 1934, to provide reasonable assurance regarding the 
reliability of financial reporting and the preparation of consolidated financial statements for external purposes in accordance with generally 
accepted accounting principles.  

The Company’s internal control over financial reporting is supported by written policies and procedures that:  

• 

• 

• 

   pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the 
Company’s assets;  
   provide reasonable assurance that transactions are recorded as necessary to permit preparation of consolidated financial statements in 
accordance with generally accepted accounting principles, and that receipts and expenditures of the Company are being made only in 
accordance with authorizations of the Company’s management and directors; and  
   provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the 
Company’s assets that could have a material effect on the consolidated financial statements.  

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any 
evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that 
the degree of compliance with the policies or procedures may deteriorate.  

In connection with the preparation of the Company’s annual consolidated financial statements, management of the Company has 

undertaken an assessment of the effectiveness of the Company’s internal control over financial reporting based on criteria established in Internal 
Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (“the COSO 
Framework”). Management’s assessment included an evaluation of the design of the Company’s internal control over financial reporting and 
testing of the operational effectiveness of the Company’s internal control over financial reporting.  

Based on this assessment, management has concluded that the Company’s internal control over financial reporting was effective as of 

March 31, 2012.  

By:   /s/ ROBERT STEFANOVICH  

  Robert Stefanovich, 
  Chief Financial Officer and Principal Executive Officer 

June 27, 2012  

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PART III  

ITEM 10.  DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE 

The information required by this Item regarding our directors, executive officers and committees of our board of directors is incorporated 
by reference to the information set forth under the captions “Election of Directors” and “Executive Compensation and Related Matters” in our 
2012 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 2012 (the “2012 Definitive Proxy 
Statement”).  

Information required by this Item regarding Section 16(a) reporting compliance is incorporated by reference to the information set forth 

under the caption “Section 16(a) Beneficial Ownership Reporting Compliance” in our 2012 Definitive Proxy Statement.  

Information required by this Item regarding our code of ethics is incorporated by reference to the information set forth under the caption 

“Corporate Governance” in Part I of this Annual Report on Form 10-K.  

ITEM 11.  EXECUTIVE COMPENSATION 

The information required by this Item is incorporated by reference to the information set forth under the caption “Executive Compensation 
and Related Matters” in our 2012 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 2012.  

I TEM 12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED 

STOCKHOLDER MATTERS 

The information required by this Item is incorporated by reference to the information set forth under the caption “Security Ownership of 
Directors and Executive Officers and Certain Beneficial Owners” in our 2012 Definitive Proxy Statement to be filed within 120 days after the 
end of our fiscal year ended March 31, 2012.  

I TEM 13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE 

The information required by this Item is incorporated by reference to the information set forth under the captions “Certain Relationships 
and Related Transactions” and “Compensation Committee Interlocks and Insider Participation” in our 2012 Definitive Proxy Statement to be 
filed within 120 days after the end of our fiscal year ended March 31, 2012.  

ITEM 14.  PRINCIPAL ACCOUNTANT FEES AND SERVICES 

The information required by this Item is incorporated by reference to the information set forth under the caption “Independent Registered 

Public Accounting Firm Fees” in our 2012 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended 
March 31, 2012.  

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I TEM 15:  Exhibits and Financial Statement Schedules. 

(a) Financial Statements  

(1) Index to Consolidated Financial Statements  

PART IV  

The financial statements required by this item are submitted in a separate section beginning on page F-1 of this report.  

Report of Independent Registered Public Accounting Firm  
Consolidated Balance Sheets at March 31, 2012 and 2011  
Consolidated Statements of Operations the years ended March 31, 2012 and 2011  
Consolidated Statements of Stockholders’ Equity for each years ended March 31, 2012 and 2011  
Consolidated Statements of Cash Flows for the years ended March 31, 2012 and 2011  
Notes to Consolidated Financial Statements  

2. 

Financial Statement Schedules 

  F-2    
  F-3    
  F-4    
  F-5    
  F-6    
  F-8    

All financial statement schedules are omitted because they were not required or the required information is included in the Consolidated 
Financial Statements and the related Notes thereto.  

3. 

Exhibit Index 

See Exhibit Index  

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CRYOPORT, INC.  

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS  

Report of Independent Registered Public Accounting Firm  
Consolidated Balance Sheets as of March 31, 2012 and 2011  
Consolidated Statements of Operations for the years ended March 31, 2012 and 2011  
Consolidated Statements of Stockholders’ Equity for the years ended March 31, 2012 and 2011  
Consolidated Statements of Cash Flows for the years ended March 31, 2012 and 2011  
Notes to Consolidated Financial Statements  

    Page   
  F-2    
  F-3    
  F-4    
  F-5    
  F-6    
  F-8    

   
  
   
   
   
   
   
   
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To the Board of Directors of  
CryoPort, Inc.  

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

We have audited the accompanying consolidated balance sheets of CryoPort, Inc. (the “Company”) as of March 31, 2012 and 2011, and the 
related consolidated statements of operations, stockholders’ equity and cash flows for the years then ended. These consolidated financial 
statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these consolidated financial 
statements based on our audits.  

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards 
require that we plan and perform the audits to obtain reasonable assurance about whether the consolidated financial statements are free of 
material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the consolidated 
financial statements. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial 
reporting. Our audits included consideration of internal control over financial reporting as a basis for designing audit procedures that are 
appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over 
financial reporting. Accordingly, we express no such opinion. An audit also includes assessing the accounting principles used and significant 
estimates made by management, as well as evaluating the overall consolidated financial statement presentation. We believe that our audits 
provide a reasonable basis for our opinion.  

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial position 
of CryoPort, Inc. at March 31, 2012 and 2011, and the results of its operations and its cash flows for the years then ended in conformity with 
accounting principles generally accepted in the United States of America.  

The accompanying consolidated financial statements have been prepared assuming the Company will continue as a going concern. As described 
in Note 1 to the consolidated financial statements, the Company has incurred recurring operating losses and has had negative cash flows from 
operations since inception. Although the Company has working capital of $4,024,120 and cash & cash equivalents of $4,617,535 at March 31, 
2012, management has estimated that cash on hand, which include proceeds from the offering received in the fourth quarter of fiscal 2012, will 
only be sufficient to allow the Company to continue its operations only into the fourth quarter of fiscal 2013. These matters raise substantial 
doubt about the Company’s ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. 
The consolidated financial statements do not include any adjustments to reflect possible future effects on the recoverability and classification of 
assets or the amount and classification of liabilities that may result from the outcome of this uncertainty.  

/s/ KMJ Corbin & Company LLP  

Costa Mesa, Califomia  
June 15, 2012  

F-2  

   
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CRYOPORT, INC.  

CONSOLIDATED BALANCE SHEETS  

ASSETS 

Current assets:  

Cash and cash equivalents  
Restricted cash  
Accounts receivable, net of allowances of $5,500 in 2012 and $9,100 in 2011  
Inventories  
Other current assets  

Total current assets  

Property and equipment, net  
Intangible assets, net  
Deposits and other assets  
Total assets  

Current liabilities:  

LIABILITIES AND STOCKHOLDERS’ EQUITY 

Accounts payable and accrued expenses  
Accrued compensation and related expenses  
Current portion of convertible debentures payable and accrued interest, net of discount of $8,843 

in 2012 and $197,226 in 2011, respectively  

Line of credit and accrued interest  
Current portion of related party notes payable  
Derivative liabilities  

Total current liabilities  

Related party notes payable and accrued interest, net of current portion  
Convertible debentures payable, net of current portion and discount of $0 in 2012 and $8,842 in 

2011, respectively  
Total liabilities  

Commitments and contingencies  
Stockholders’ equity:  

Additional paid-in capital  
Accumulated deficit  

Preferred stock, $0.001 par value, 2,500,000 shares authorized, none issued and outstanding  
Common stock, $0.001 par value; 250,000,000 shares authorized; 37,760,628 and 27,504,604 

shares issued and outstanding at March 31, 2012 and 2011, respectively  

Total stockholders’ equity  

Total liabilities and stockholders’ equity  

See accompanying notes to consolidated financial statements.  

F-3  

March 31, 

2012 

2011 

$  4,617,535      
251,368      
146,124      
51,754      
65,970      
   5,132,751      
682,021      
379,083      
19,744      
$  6,213,599      

$  9,278,443    
91,169    
55,794    
44,224    
528,045    
   9,997,675    
669,580    
354,854    
9,358    
$ 11,031,467    

$ 

401,399      
235,996      

$ 

506,887    
402,746    

337,902      
—        
96,000      
37,334      
   1,108,631      
   1,375,448      

   1,979,402    
90,388    
102,000    
156,497    
   3,237,920    
   1,423,412    

—        
   2,484,079      

421,726    
   5,083,058    

—        

—      

37,761      
   63,620,774      
  (59,929,015 )    
   3,729,520      
$  6,213,599      

27,505    
   58,016,991    
  (52,096,087 )  
   5,948,409    
$ 11,031,467    

   
   
  
   
  
  
   
     
  
   
  
   
  
   
   
  
  
   
  
  
   
  
  
   
  
  
   
    
    
  
  
    
   
  
   
   
  
  
   
  
  
   
  
  
   
    
    
  
  
    
   
  
   
   
    
    
  
  
    
   
  
   
  
   
  
   
   
  
  
   
  
   
  
  
   
  
  
   
  
  
   
    
    
  
  
    
   
  
   
   
   
  
  
   
    
    
  
  
    
   
  
   
   
    
    
  
  
    
   
  
   
  
   
  
  
   
  
  
   
   
   
    
    
  
  
    
   
  
   
   
    
    
  
  
    
   
  
   
   
    
    
  
  
    
   
  
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CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF OPERATIONS  

Revenues  
Cost of revenues  
Gross loss  
Operating expenses:  

Selling, general and administrative  
Research and development  
Total operating expenses  

Loss from operations  
Other (expense) income:  
Interest income  
Interest expense  
Change in fair value of derivative liabilities  
Total other expense, net  

Loss before provision for income taxes  
Provision for income taxes  
Net loss  
Net loss per common share, basic and diluted  
Basic and diluted weighted average common shares outstanding  

Years Ended March 31, 

2012 
555,637      
$ 
   1,392,460      
(836,823 )    

2011 
475,504    
$ 
   1,302,988    
(827,484 )  

   6,106,006      
491,849      
   6,597,855      
   (7,434,678 )    

   4,320,461    
449,129    
   4,769,590    
   (5,597,074 )  

11,940      
(527,753 )    
119,163      
(396,650 )    
   (7,831,328 )    
1,600      
$ (7,832,928 )    
$ 
(0.27 )    
  28,974,843      

15,571    
(618,765 )  
49,590    
(553,604 )  
   (6,150,678 )  
1,600    
$ (6,152,278 )  
$ 
(0.46 )  
  13,301,769    

See accompanying notes to consolidated financial statements.  

F-4  

   
   
  
   
  
  
   
     
  
   
   
   
    
    
  
  
    
    
  
   
  
  
   
    
    
  
  
    
    
  
   
  
   
   
  
  
   
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
   
  
   
  
  
   
  
  
   
  
  
   
    
    
  
  
    
    
  
   
  
  
   
    
    
  
  
    
    
  
   
   
  
  
   
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
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CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY  

CRYOPORT, INC.  

Balance at April 1, 2010  
Issuance of common stock for conversion of 

convertible debentures  

Reclassification of derivative liability to 

additional paid-in capital  

Reduction of accrued offering costs in 

connection with February 2010 financing  

Issuance of common stock for services  
Exercise of warrants and options for cash  
Cashless exercise of warrants  
Issuance of units in private placement offering, 

net of offering costs of $1,776,605  
Share-based compensation related to stock 

options and warrants issued to consultants, 
employees and directors  

Net loss  
Balance at March 31, 2011  
Exercise of warrants for cash  
Cashless exercise of warrants  
Offering costs in connection with the February 

2011 private placement offering  

Estimated fair value of common stock warrants 
issued to convertible debenture holders  
Issuance of units in private placement offering, 

net of offering costs of $572,255  

Share-based compensation related to stock 

options and warrants issued to consultants, 
employees and directors  

Net loss  
Balance at March 31, 2012  

Preferred Stock 

Common Stock 

   Shares       Amount      
   —         $  —        

Shares 

      Amount       

   8,136,640       $  8,137       $ 45,021,097       $ (45,943,809 )     $ 

Additional  
Paid-in  
Capital 

Accumulated  
Deficit 

Total  
Stockholders’  
Equity 
(914,575 )  

   —        

   —        

66,666      

67      

199,933      

—        

200,000    

   —        

   —        

—        

   —        

128,276      

—        

128,276    

   —        
   —        
   —        
   —        

   —        
   —        
   —        
   —        

—        
13,636      
279,094      
114,061      

   —        
14      
279      
114      

29,067      
23,985      
212,924      
(114 )    

—        
—        
—        
—        

29,067    
23,999    
213,203    
—      

   —        

   —        

  18,894,507      

  18,894      

  11,430,665      

—        

  11,449,559    

   —        
   —        
   —        
   —        
   —        

   —        
   —        
   —        
   —        
   —        

—        
—        
  27,504,604      
742,380      
36,090      

   —        
   —        
  27,505      
742      
36      

971,158      
—        
  58,016,991      
570,888      
(36 )    

—        
   (6,152,278 )    
  (52,096,087 )    
—        
—        

971,158    
   (6,152,278 )  
   5,948,409    
571,630    
—      

   —        

   —        

—        

   —        

(36,543 )    

—        

(36,543 )  

   —        

   —        

—        

   —        

156,999      

—        

156,999    

   —        

   —        

   9,477,554      

   9,478      

   4,630,922      

—        

   4,640,400    

   —        
   —        
   —        
   —        
   —         $  —        

—        
—        

281,553    
   (7,832,928 )  
  37,760,628       $ 37,761       $ 63,620,774       $ (59,929,015 )     $  3,729,520    

—        
   (7,832,928 )    

281,553      
—        

   —        
   —        

See accompanying notes to consolidated financial statements.  

F-5  

   
   
  
  
     
     
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
    
  
  
    
   
  
  
    
    
  
  
    
   
  
  
    
    
  
  
   
    
  
  
    
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
    
    
  
  
    
   
  
  
    
    
  
  
    
   
  
  
    
    
  
  
   
    
  
  
    
    
  
  
  
    
    
  
  
    
   
  
  
    
    
  
  
    
   
  
  
    
    
  
  
   
    
  
  
    
    
  
Table of Contents  

CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF CASH FLOWS  

OPERATING ACTIVITIES  

Net loss  
Adjustments to reconcile net loss to net cash used in operating activities:  

Depreciation and amortization  
Amortization of debt discount  
Fair value of warrants issued to convertible debenture holders  
Fair value of stock options and warrants issued to consultants, employees and directors  
Change in fair value of derivative instruments  
Loss on disposal of cryogenic shippers  
Interest accrued on restricted cash  
Changes in operating assets and liabilities:  

Accounts receivable  
Inventories  
Other assets  
Accounts payable and accrued expenses  
Accrued compensation and related expenses  
Accrued interest  

Net cash used in operating activities  

INVESTING ACTIVITIES  

Purchases of intangible assets  
Purchases of property and equipment  
Net cash used in investing activities  

FINANCING ACTIVITIES  

Proceeds from issuance of common stock, net of cash paid for issuance costs  
Repayment of convertible debentures payable  
Repayment of deferred financing costs  
Repayment of related party notes payable  
Restricted cash – convertible debenture holder escrow account funds  
Proceeds from release of restricted cash  
Payment on line of credit  
Proceeds from exercise of options and warrants  
Net cash provided by financing activities  

Net change in cash and cash equivalents  
Cash and cash equivalents, beginning of year  
Cash and cash equivalents, end of year  
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION  

Cash paid during the year for:  
Interest  
Income taxes  

F-6  

Years Ended March 31, 

2012 

2011 

$ (7,832,928 )    

$ (6,152,278 )  

343,029      
197,225      
156,999      
559,091      
(119,163 )    
8,362      
(274 )    

245,477    
522,041    
—      
477,620    
(49,590 )  
6,517    
(765 )  

(90,330 )    
(7,530 )    
174,151      
(62,241 )    
(166,750 )    
60,225      
  (6,780,134 )    

25,242    
16,004    
(155,851 )  
(109,728 )  
306,744    
57,156    
   (4,811,411 )  

(125,420 )    
(262,641 )    
(388,061 )    

(124,050 )  
(341,400 )  
(465,450 )  

   4,718,880      
  (2,273,028 )    
(158,270 )    
(102,000 )    
(251,368 )    
91,443      
(90,000 )    
571,630      
   2,507,287      
  (4,660,908 )    
   9,278,443      
$ 4,617,535      

  11,571,286    
(423,372 )  
(275,699 )  
(160,000 )  
—      
—      
—      
213,203    
  10,925,418    
   5,648,557    
   3,629,886    
$  9,278,443    

113,305      
1,600      

39,568    
1,600    

   
   
  
   
  
  
   
     
  
   
  
   
   
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
    
   
  
  
    
    
  
   
   
    
   
  
  
    
    
  
   
  
   
  
  
   
  
  
   
    
   
  
  
    
    
  
   
  
  
   
    
   
  
  
    
    
  
   
  
   
   
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
    
   
  
  
    
    
  
   
   
    
   
  
  
    
    
  
   
   
   
    
   
  
  
    
    
  
   
   
    
   
  
  
    
    
  
   
  
   
  
   
  
  
   
    
   
  
  
    
    
  
   
  
  
   
    
   
  
  
    
    
  
Table of Contents  

CONSOLIDATED STATEMENTS OF CASH FLOWS (CONTINUED)  

CRYOPORT, INC.  

SUPPLEMENTAL DISCLOSURE OF NON-CASH INVESTING AND FINANCING ACTIVITIES:  
Offering costs in connection with equity financing included in accounts payable  
Settlement of accounts payable with shares of common stock  
Reduction of accrued offering costs in connection with February 2010 financing  
Conversion of debt to common stock  
Cashless exercise of warrants and stock options  
Fair value of options issued to employee in lieu of cash bonus  
Reclassification of derivative liabilities to additional paid-in capital upon fixing conversion feature and warrant 

price  

Estimated fair value of warrants issued to related party in connection with an advisory services agreement  
Reclassification of property and equipment to inventories  

Years Ended March 31, 
2011 
2012 

$ 78,480       
$  —         
$  —         
$  —         
$ 
36       
$  —         

$ 121,727    
$  23,999    
$  29,067    
$ 200,000    
$ 
114    
$ 216,000    

$  —         
$  —         
$  —         

$ 128,276    
$ 302,769    
$  60,228    

See accompanying notes to consolidated financial statements.  

F-7  

   
   
  
   
  
  
   
      
  
   
   
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
   
   
    
   
  
   
    
    
  
Table of Contents  

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS  

Note 1. Organization and Summary of Significant Accounting Policies  

The Company  

CryoPort, Inc. (the “Company” or “we”) is a provider of an innovative cold chain frozen shipping system dedicated to providing superior, 

affordable cryogenic shipping solutions that ensure the safety, status and temperature of high value, temperature sensitive materials. The 
Company has developed cost-effective reusable cryogenic transport containers (referred to as a “shipper”) capable of transporting biological, 
environmental and other temperature sensitive materials at temperatures below minus 150° Celsius. These dry vapor shippers are one of the first 
significant alternatives to using dry ice and achieve 10-plus day holding times compared to one to two day holding times with dry ice (assuming 
no re-icing during transit). The Company’s value proposition comes from both providing safe transportation and an environmentally friendly, 
long lasting shipper, and through its value-added services that offer a simple hassle-free solution for its customers. These value-added services 
include an internet-based web portal that enables the customer to conveniently initiate scheduling, shipping and tracking of the progress and 
status of a shipment, and provide in-transit temperature and custody transfer monitoring of the shipper. Our service also provides a fully ready 
charged shipper containing all freight bills, customs documents and regulatory paperwork for the entire journey of the shipper to its customers at 
their pick up location.  

The Company’s principal focus has been the further development and commercial launch of CryoPort Express  Portal, an innovative IT 

® 

solution for shipping and tracking high-value specimens through overnight shipping companies, and it’s CryoPort Express  Shipper, a dry vapor 
cryogenic shipper for the transport of biological and pharmaceutical materials. A dry vapor cryogenic shipper is a container that uses liquid 
nitrogen in dry vapor form, which is suspended inside a vacuum insulated bottle as a refrigerant, to provide storage temperatures below minus 
150° Celsius. The dry vapor shipper is designed using innovative, proprietary, and patented technology which prevents spillage of liquid 
nitrogen and pressure build up as the liquid nitrogen evaporates. A proprietary retention system is employed to ensure that liquid nitrogen stays 
inside the vacuum container, even when placed upside-down or on its side as is often the case when in the custody of a shipping company. 
Biological specimens are stored in a specimen chamber, referred to as a “well” inside the containers and refrigeration is provided by non-
hazardous cold nitrogen gas evolving from the liquid nitrogen entrapped within the retention system surrounding the well. Biological specimens 
transported using our cryogenic shipper can include clinical samples, diagnostics, live cell pharmaceutical products (such as cancer vaccines, 
semen and embryos, and infectious substances) and other items that require and/or are protected through continuous exposure to frozen or 
cryogenic temperatures (less than minus 150° Celsius).  

® 

The Company entered into its first strategic relationship with the global courier Federal Express Corporation (“FedEx”) on January 13, 

2010 pursuant to which the Company leases to FedEx such number of its cryogenic shippers that FedEx, from time to time, orders for FedEx’s 
customers. Under this agreement, FedEx has the right to and shall, on a non-exclusive basis, promote market and sell transportation of the 
Company’s shippers and its related value-added goods and services, such as its data logger, web portal and planned CryoPort Express  Smart 
Pak System. On January 24, 2011 we announced that FedEx had launched its deep frozen shipping solution using our CryoPort Express  Dry 
Shipper. On September 2, 2010, the Company entered into an agreement with another global courier, DHL Express (USA), Inc. (“DHL”), that 
gives DHL life science customers direct access to the Company’s web-based order entry and tracking portal to order the CryoPort Express  Dry 
Shipper and receive preferred DHL shipping rates. The agreement covers DHL shipping discounts that may be used to support the Company’s 
customers using the CryoPort Express  shipping solution. In connection with the agreement, the Company has integrated its proprietary web 
portal to DHL’s tracking and billing systems to provide DHL life science customers with a seamless way of shipping their critical biological 
material worldwide. The IT integration with DHL was completed during the Company’s fourth quarter of fiscal year 2011.  

® 

® 

® 

® 

F-8  

   
Table of Contents  

We offer our solution to companies in the life sciences industry. These companies operate within a heavily regulated environment and as 

such, changing vendors and distribution practices typically require a number of steps which may include the audit of our facilities, review of our 
procedures, qualifying us as a vendor, and performing test shipments. This process can take several months or longer to complete prior to a 
company fully adopting the Cryoport Express  solution.  

® 

Going Concern  

The consolidated financial statements have been prepared using the accrual method of accounting in accordance with accounting principles 

generally accepted in the United States of America (“U.S.”) (“GAAP”) and have been prepared on a going concern basis, which contemplates 
the realization of assets and the settlement of liabilities in the normal course of business. We have sustained operating losses since our inception 
and have used substantial amounts of working capital in our operations. Further, at March 31, 2012, we had an accumulated deficit of 
$(59,929,015), we had a net loss of $(7,832,928) and we used cash in operations of $(6,780,134) during the year ended March 31, 2012. These 
factors raise substantial doubt about our ability to continue as a going concern.  

We expect to continue to incur substantial additional operating losses from costs related to the commercialization of our CryoPort Express 
solution. We believe that our working capital at March 31, 2012 of approximately $4.0 million, together with the revenues generated from our 

® 
services, the continued focus on cost reductions of non-sales generating costs and the net proceeds from the recent private placement in fiscal 
2012, are sufficient to sustain our planned operations into the fourth quarter of 2013; however, we cannot assure you of this and we may require 
additional debt or equity financing in the future to maintain operations.  

Future capital requirements will depend upon many factors, including the success of our commercialization efforts and the level of 
customer adoption of our CryoPort Express  Solution as well as our ability to establish additional collaborative arrangements. We cannot make 
any assurances that the sales ramp together with cost reduction measures will lead to achievement of sustained profitable operations or that any 
additional financing will be completed on a timely basis, on acceptable terms or at all. Management’s inability to successfully achieve significant 
sales increases or its cost reduction strategies, or to complete any other financing will adversely impact our ability to continue as a going 
concern.  

® 

Basis of Presentation  

The accompanying consolidated financial statements have been prepared in accordance with GAAP.  

Principles of Consolidation  

The consolidated financial statements include the accounts of CryoPort, Inc. and its wholly owned subsidiary, CryoPort Systems, Inc. All 

intercompany accounts and transactions have been eliminated.  

Use of Estimates  

The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions 
that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements 
and the reported amounts of revenues and expenses during the reporting periods. Actual results could differ from estimated amounts. The 
Company’s significant estimates include allowances for doubtful accounts and sales returns, recoverability of long-lived assets, allowance for 
inventory obsolescence, deferred taxes and their accompanying valuations, valuation of derivative liabilities and valuation of common stock, 
warrants and stock options issued for products or services.  

Fair Value of Financial Instruments  

The Company’s financial instruments consist of cash and cash equivalents, restricted cash, accounts receivable, related-party notes 

payable, a line of credit, convertible notes payable, accounts payable and accrued  

F-9  

   
Table of Contents  

expenses. The carrying value for all such instruments approximates fair value at March 31, 2012 and 2011. The difference between the fair value 
and recorded values of the related party notes payable is not significant. The Company’s restricted cash is carried at amortized cost which 
approximates fair value at March 31, 2012 and 2011.  

Cash and Cash Equivalents  

The Company considers highly liquid investments with original maturities of 90 days or less to be cash equivalents.  

Concentrations of Credit Risk  

The Company maintains its cash accounts in financial institutions. Accounts at these institutions are insured by the Federal Deposit 
Insurance Corporation (“FDIC”) with basic deposit coverage limits up to $250,000 per owner. In addition to the basic insurance deposit 
coverage, the FDIC is providing temporary unlimited coverage for noninterest-bearing transaction accounts from December 31, 2010 through 
December 31, 2012. At March 31, 2012 and 2011, the Company had approximately $0 and $8,701,000 which exceeded the FDIC insurance 
limit, respectively, of cash balances, including restricted cash. The Company performs ongoing evaluations of these institutions to limit its 
concentration risk exposure.  

Restricted cash  

In conjunction with the private placement in February 2012, the Company was required to deposit $444,168 into an escrow account 

representing the total future principal payments due to one the convertible debenture holders (see Note 8). At March 31, 2012, $251,368 
remained in escrow and will be disbursed to the note holder during the first quarter of fiscal year 2013. Previously, the Company also invested 
cash in a one year restricted certificate of deposit bearing interest at 1% which serves as collateral for borrowings under a line of credit 
agreement (see Note 6). During 2012 the Company repaid the line of credit and the previously restricted cash balances were released to the 
Company. At March 31, 2011, the balance in the certificate of deposit was $91,169.  

Customers  

The Company grants credit to customers within the U.S. and to a limited number of international customers and does not require collateral. 
Revenues from international customers are generally secured by advance payments except for a limited number of established foreign customers. 
The Company generally requires advance or credit card payments for initial revenues from new customers. The Company’s ability to collect 
receivables is affected by economic fluctuations in the geographic areas and industries served by the Company. Reserves for uncollectible 
amounts are provided based on past experience and a specific analysis of the accounts, which management believes is sufficient. Accounts 
receivable at March 31, 2012 and 2011 are net of reserves for doubtful accounts of approximately $5,500 and $9,100, respectively. Although the 
Company expects to collect amounts due, actual collections may differ from the estimated amounts.  

The Company has foreign revenues primarily in Europe, Japan, Canada, India and Australia. During fiscal years 2012 and 2011, the 
Company had foreign revenues of approximately $301,000 and $232,000, respectively, which constituted approximately 54% and 51% of total 
revenues, respectively.  

The majority of the Company’s customers are in the biotechnology, pharmaceutical and life science industries. Consequently, there is a 

concentration of receivables within these industries, which is subject to normal credit risk. At March 31, 2012, annual revenues from three 
customers accounted for 31% of our total revenues. At March 31, 2011 annual revenues from three customers accounted for 68% of our total 
revenues. The Company maintains reserves for bad debt and such losses, in the aggregate, historically have not exceeded our estimates.  

F-10  

   
Table of Contents  

Inventories  

Inventories are stated at the lower of cost or current estimated market value. Cost is determined using the standard cost method which 
approximates the first-in, first-to-expire method. Inventories are reviewed periodically for slow-moving or obsolete status. The Company write 
downs the carrying value of its inventories to reflect situations in which the cost of inventories is not expected to be recovered. Once established, 
write-downs of inventories are considered permanent adjustments to the cost basis of the obsolete or excess inventories. Raw materials and 
finished goods include material costs less reserves for obsolete or excess inventories. The Company evaluates the current level of inventories 
considering historical trends and other factors, and based on the evaluation, records adjustments to reflect inventories at its net realizable value. 
These adjustments are estimates, which could vary significantly from actual results if future economic conditions, customer demand, competition 
or other relevant factors differ from expectations. These estimates require us to make assessments about future demand for the Company’s 
products in order to categorize the status of such inventories items as slow-moving, obsolete or in excess-of-need. These estimates are subject to 
the ongoing accuracy of the Company’s forecasts of market conditions, industry trends, competition and other factors.  

Property and Equipment  

The Company provides shipping containers to its customers and charges a fee in exchange for the use of the container. The Company’s 

arrangements are similar to the accounting standard for leases since they convey the right to use the container over a period of time. The 
Company retains the title to the containers and provides its customers the use of the container for a specific shipping cycle. At the culmination of 
the customer’s shipping cycle, the container is returned to the Company. As a result, the Company classifies the containers as fixed assets for the 
per-use container program.  

Property and equipment are recorded at cost. Cryogenic shippers, which comprise of 84% of the Company’s net property and equipment 
balance at March 31, 2012 and 2011 are depreciated using the straight-line method over their estimated useful lives of three years. Equipment 
and furniture are depreciated using the straight-line method over their estimated useful lives (generally three to seven years) and leasehold 
improvements are amortized using the straight-line method over the estimated useful life of the asset or the lease term, whichever is shorter. 
Equipment acquired under capital leases is amortized over the estimated useful life of the assets or term of the lease, whichever is shorter and 
included in depreciation expense.  

Betterments, renewals and extraordinary repairs that extend the lives of the assets are capitalized; other repairs and maintenance charges 

are expensed as incurred. The cost and related accumulated depreciation and amortization applicable to assets retired are removed from the 
accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets are comprised of patents and trademarks and software development costs. The Company capitalizes costs of obtaining 

patents and trademarks which are amortized, using the straight-line method over their estimated useful life of five years. The Company 
capitalizes certain costs related to software developed for internal use. Software development costs incurred during the preliminary or 
maintenance project stages are expensed as incurred, while costs incurred during the application development stage are capitalized and amortized 
using the straight-line method over the estimated useful life of the software, which is five years. Capitalized costs include purchased materials 
and costs of services including the valuation of warrants issued to consultants.  

Long-lived Assets  

If indicators of impairment exist, we assess the recoverability of the affected long-lived assets by determining whether the carrying value 

of such assets can be recovered through undiscounted future operating  

F-11  

   
Table of Contents  

cash flows. If impairment is indicated, we measure the amount of such impairment by comparing the fair value to the carrying value. We believe 
the future cash flows to be received from the long-lived assets will exceed the assets’ carrying value, and accordingly, we have not recognized 
any impairment losses through March 31, 2012.  

Deferred Financing Costs  

Deferred financing costs represent costs incurred in connection with the issuance of the convertible notes payable and private equity 
financing. Deferred financing costs related to the issuance of debt are being amortized over the term of the financing instrument using the 
effective interest method while deferred financing costs from equity financings are netted against the gross proceeds received from the equity 
financings.  

During the year ended March 31, 2012, the Company incurred $572,255 of offering costs in connection with the private placement that 
closed in February and March 2012, which were charged to additional paid-in capital and netted against the proceeds received in the private 
placements. As of March 31, 2012, offering costs of $78,480 related to the private placement were included in accounts payable and accrued 
expenses in the accompanying consolidated balance sheet.  

During the year ended March 31, 2011, the Company incurred $465,023 of offering costs in connection with the private placement that 
closed in August and October 2010 and $1,311,582 of offering costs from the private placement that closed in February 2011; both of which 
were charged to additional paid-in capital and netted against the proceeds received in the private placements. During the year ended March 31, 
2012, the Company made payments of $158,270 for offering costs and financing fees related to the February 2011 private placement of which 
$121,727 is included in accounts payable and accrued expenses as of March 31, 2011 in the accompanying consolidated balance sheet.  

Convertible Debentures  

If a conversion feature of conventional convertible debt is not accounted for as a derivative instrument and provides for a rate of 

conversion that is below market value, this feature is characterized as a beneficial conversion feature (“BCF”). A BCF is recorded by the 
Company as a debt discount. The convertible debt is recorded net of the discount related to the BCF. The Company amortizes the discount to 
interest expense over the life of the debt using the effective interest rate method.  

Derivative Liabilities  

Certain of the Company’s issued and outstanding common stock purchase warrants which have exercise price reset features are treated as 

derivatives for accounting purposes. The common stock purchase warrants were not issued with the intent of effectively hedging any future cash 
flow, fair value of any asset, liability or any net investment in a foreign operation. The warrants do not qualify for hedge accounting, and as such, 
all future changes in the fair value of these warrants are recognized currently in earnings until such time as the warrants are exercised, expire or 
the related rights have been waived. These common stock purchase warrants do not trade in an active securities market, and as such, the 
Company estimates the fair value of these warrants using the Black-Scholes option pricing model (“Black-Scholes”) (see Note 9).  

Commitments and Contingencies  

The Company is subject to routine claims and litigation incidental to our business. In the opinion of management, the resolution of such 

claims is not expected to have a material adverse effect on our operating results or financial position.  

Income Taxes  

The Company accounts for income taxes under the provision of the Financial Accounting Standards Board (“FASB”) Accounting 

Standards Codification (“ASC”) 740, Income Taxes , or ASC 740. The Company is a  

F-12  

   
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subchapter “C” corporation and files a federal income tax return. The Company files state income tax returns in California.  

Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those 

temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is 
recognized in income in the period that includes the enactment date. A valuation allowance is provided for certain deferred tax assets if it is more 
likely than not that the Company will not realize tax assets through future operations. Based on the weight of available evidence, the Company’s 
management has determined that it is more likely than not that the net deferred tax assets will not be realized. Therefore, the Company has 
recorded a full valuation allowance against the net deferred tax assets. The Company’s income tax provision consists of state minimum taxes.  

ASC 740, which clarifies the accounting for uncertainty in income taxes recognized in the financial statements, provides that a tax benefit 
from an uncertain tax position may be recognized when it is more likely than not that the position will be sustained upon examination, including 
resolutions of any related appeals or litigation processes, based on the technical merits. Income tax positions must meet a more likely than not 
recognition threshold. As of March 31, 2012 and 2011, there were no unrecognized tax benefits included in the accompanying consolidated 
balance sheets that would, if recognized, affect the effective tax rates. It is not anticipated that there will be a significant change in the 
unrecognized tax benefits over the next twelve months.  

The Company’s policy is to recognize interest and/or penalties related to income tax matters in income tax expense. The Company had no 

accrual for interest or penalties on its consolidated balance sheets at March 31, 2012 and 2011, respectively and has not recognized interest 
and/or penalties in the consolidated statement of operations for the years ended March 31, 2012 and 2011. The Company is subject to taxation in 
the U.S. and various state jurisdictions. As of March 31, 2012, the Company is no longer subject to U.S. federal examinations for years before 
2008 and for California franchise and income tax examinations for years before 2007. However, to the extent allowed by law, the taxing 
authorities may have the right to examine prior periods where net operating losses were generated and carried forward, and make adjustments up 
to the amount of the net operating loss carry forward amount. The Company is not currently under examination by U.S. federal or state 
jurisdictions.  

Supply Concentration Risks  

The component parts for our products are primarily manufactured at third party manufacturing facilities. The Company also has a 

warehouse at our corporate offices in Lake Forest, California, where the Company is capable of manufacturing certain parts and fully assembles 
its products. Most of the components that the Company uses in the manufacture of its products are available from more than one qualified 
supplier. For some components, however, there are relatively few alternate sources of supply and the establishment of additional or replacement 
suppliers may not be accomplished immediately, however, the Company has identified alternate qualified suppliers which the Company believes 
could replace existing suppliers. Should this occur, the Company believes that with its current level of shippers and production rate the Company 
has enough to cover a four to six week gap in maximum disruption of production.  

There are no specific agreements with any manufacturer nor are there any long term commitments to any manufacturer. The Company 

believes that any of the manufactures currently used by it could be replaced within a short period of time as none have a proprietary component 
or a substantial capital investment specific to its products.  

Revenue Recognition  

The Company provides shipping containers to their customers and charges a fee in exchange for the use of the container. The Company’s 

arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a period of time. The 
Company retains title to the containers and provides its  

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customers the use of the container for a specified shipping cycle. At the culmination of the customer’s shipping cycle, the container is returned to 
the Company.  

The Company recognizes revenue for the use of the shipper at the time of the delivery of the shipper to the end user of the enclosed 

materials, and at the time that collectability is reasonably certain. Revenue is based on gross net of discounts and allowances.  

Accounting for Shipping and Handling Revenue, Fees and Costs  

The Company classifies amounts billed for shipping and handling as revenue. Shipping and handling fees and costs are included in cost of 

sales in the accompanying consolidated statements of operations.  

Research and Development Expenses  

Expenditures relating to research and development are expensed in the period incurred. Research and development expenses to date have 

consisted primarily of costs associated with the continually improving the features of the CryoPort Express  System including the web based 
customer service portal and the CryoPort Express  Shippers. Further, these efforts are expected to lead to the introduction of shippers of varying 
sizes based on market requirements, constructed of lower cost materials and utilizing high volume manufacturing methods that will make it 
practical to provide the cryogenic packages offered by the CryoPort Express  System. Other research and development effort has been directed 
toward improvements to the liquid nitrogen retention system to render it more reliable in the general shipping environment and to the design of 
the outer packaging. Alternative phase change materials in place of liquid nitrogen may be used to increase the potential markets these shippers 
can serve such as ambient and 2-8°C markets.  

® 

® 

® 

Stock-based Compensation  

The Company accounts for stock-based payments to employees and directors in accordance with stock-based payment accounting 
guidance which requires all stock-based payments to employees and directors, including grants of employee stock options and warrants, to be 
recognized based upon their fair values. The fair value of stock-based awards is estimated at grant date using Black-Scholes and the portion that 
is ultimately expected to vest is recognized as compensation cost over the requisite service period.  

Since stock-based compensation is recognized only for those awards that are ultimately expected to vest, the Company has applied an 

estimated forfeiture rate to unvested awards for the purpose of calculating compensation cost. These estimates will be revised, if necessary, in 
future periods if actual forfeitures differ from estimates. Changes in forfeiture estimates impact compensation cost in the period in which the 
change in estimate occurs. The estimated forfeiture rates at March 31, 2012 and 2011 was zero as the Company has not had a significant history 
of forfeitures and does not expect significant forfeitures in the future.  

Cash flows from the tax benefits resulting from tax deductions in excess of the compensation cost recognized for those options or warrants 

are classified as financing cash flows. Due to the Company’s loss position, there were no such tax benefits during years ended March 31, 2012 
and 2011.  

The Company uses Black-Scholes to estimate the fair value of stock-based awards. The determination of fair value using Black-Scholes is 

affected by its stock price as well as assumptions regarding a number of complex and subjective variables, including expected stock price 
volatility, risk-free interest rate, expected dividends and projected employee stock option exercise behaviors.  

The Company’s stock-based compensation plans are discussed further in Note 11.  

Equity Instruments Issued to Non-Employees for Acquiring Goods or Services  

Issuances of the Company’s common stock for acquiring goods or services are measured at the fair value of the consideration received or 

the fair value of the equity instruments issued, whichever is more reliably  

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measurable. The measurement date for the fair value of the equity instruments issued to consultants or vendors is determined at the earlier of 
(i) the date at which a commitment for performance to earn the equity instruments is reached (a “performance commitment” which would 
include a penalty considered to be of a magnitude that is a sufficiently large disincentive for nonperformance) or (ii) the date at which 
performance is complete. When it is appropriate for the Company to recognize the cost of a transaction during financial reporting periods prior to 
the measurement date, for purposes of recognition of costs during those periods, the equity instrument is measured at the then-current fair values 
at each of those interim financial reporting dates (see Note 12).  

Basic and Diluted Loss Per Share  

Basic loss per common share is computed based on the weighted average number of shares outstanding during the period. Diluted loss per 
share is computed by dividing net loss by the weighted average shares outstanding assuming all dilutive potential common shares were issued. In 
addition, in computing the dilutive effect of convertible securities, the numerator is adjusted to add back the after-tax amount of interest, if any, 
recognized in the period with any convertible debt. For the years ended March 31, 2012 and 2011, the Company was in a loss position and the 
basic and diluted loss per share are the same since the effect of stock options, warrants and convertible notes payable on loss per share was anti-
dilutive and thus not included in the diluted loss per share calculation. The impact under the treasury stock method of dilutive stock options and 
warrants and the if-converted method of convertible debt would have resulted in weighted average common shares outstanding of approximately 
34,128,000 and 16,089,000 for the years ended March 31, 2012 and 2011, respectively.  

Segment Reporting  

We currently operate in only one segment.  

New Accounting Pronouncements  

In June 2011, the FASB updated the accounting guidance on alignment of disclosures for U.S. GAAP and the International Financial 
Reporting Standards, or IFRS, by updating Topic 820 entitled “Amendments to Achieve Common Fair Value Measurement and Disclosure 
Requirements in U.S. GAAP and IFRS”, relating to presentation of fair value measurements reported in financial statements. The updated 
guidance requires companies to align fair value measurement and disclosure requirements between U.S. GAAP and IFRS. The updated guidance 
is effective beginning in our fiscal 2013 year and earlier adoption is not permitted. The adoption of this guidance is not expected to have a 
material impact on our financial position or results of operations.  

Note 2. Inventories  

Inventories consist of the following:  

Raw materials  
Finished goods  

March 31, 

March 31, 

2012 
$ 32,559       
  19,195       
$ 51,754       

2011 
$ 37,739    
   6,485    
$ 44,224    

The Company’s inventories consists of accessories that are sold and shipped to customers along with pay-per-use containers and are not 

returned to the Company along with the containers at the culmination of the customer’s shipping cycle. Inventories are stated at the lower of 
standard cost or current estimated market value. Cost is determined using the standard cost method which approximates the first-in, first-to-
expire method.  

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Note 3. Property and Equipment  

Equipment and leasehold improvements and related accumulated depreciation and amortization are as follows:  

Cryogenic shippers  
Furniture and fixtures  
Machinery and equipment  
Leasehold improvements  

Less accumulated depreciation and amortization  

March 31, 

2012 
$  882,471      
30,746      
   377,919      
30,913      
  1,322,049      
   (640,028 )    
$  682,021      

2011 
$  689,757    
3,284    
   355,303    
19,426    
  1,067,770    
   (398,190 )  
$  669,580    

The Company’s current business plan focuses on per-use leasing of shipping containers and added-value services that will be used by us to 

provide an end-to-end and cost-optimized shipping solutions.  

Total depreciation and amortization expense related to property and equipment amounted to $241,838 and $164,316 for the years ended 

March 31, 2012 and 2011, respectively.  

Note 4. Intangible Assets  

Intangible assets are comprised of patents and trademarks and software developed for internal uses. The gross book values and 

accumulated amortization as of March 31, 2012 and 2011 were as follows:  

Patents and trademarks  
Software development costs  

Less accumulated amortization  

March 31, 

2012 
$ 131,856      
   564,049      
   695,905      
  (316,822 )    
$ 379,083      

2011 
$  91,354    
   479,131    
   570,485    
  (215,631 )  
$ 354,854    

Amortization expense for intangible assets for the years ended March 31, 2012 and 2011 was $101,191 and $81,161, respectively. All of 

the Company’s intangible assets are subject to amortization.  

Years Ending March 31, 
2013  
2014  
2015  
2016  
2017  

Patents and 
Trademarks       
$  16,634       
   16,607       
   15,560       
   15,146       
   15,146       
$  79,093       

Software        
$ 112,787       
   94,099       
   46,236       
   33,785       
   13,083       
$ 299,990       

Total  
Intangibles   
$ 129,421    
  110,706    
   61,796    
   48,931    
   28,229    
$ 379,083    

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Note 5. Fair Value Measurements  

The Company determines the fair value of its derivative instruments using a three-level hierarchy for fair value measurements which these 

assets and liabilities must be grouped, based on significant levels of observable or unobservable inputs. Observable inputs reflect market data 
obtained from independent sources, while unobservable inputs reflect the Company’s market assumptions. This hierarchy requires the use of 
observable market data when available. These two types of inputs have created the following fair-value hierarchy:  

Level 1 — Valuations based on unadjusted quoted market prices in active markets for identical securities. Currently the Company does not 

have any items classified as Level 1.  

Level 2 — Valuations based on observable inputs (other than Level 1 prices), such as quoted prices for similar assets at the measurement 

date; quoted prices in markets that are not active; or other inputs that are observable, either directly or indirectly.  

Level 3 — Valuations based on inputs that are unobservable and significant to the overall fair value measurement, and involve 

management judgment. The Company uses the Black-Scholes option pricing model to determine the fair value of the instruments. If the inputs 
used to measure fair value fall in different levels of the fair value hierarchy, a financial security’s hierarchy level is based upon the lowest level 
of input that is significant to the fair value measurement.  

The following table presents the Company’s warrants measured at fair value on a recurring basis as of March 31, 2012 and 2011 classified 

using the valuation hierarchy:  

Derivative Liabilities  

Level 3  
Carrying Value 

Level 3  
Carrying Value 

March 31, 2012       
37,334       
$ 

March 31, 2011   
156,497    
$ 

The following table provides a reconciliation of the beginning and ending balances for the Company’s derivative liabilities measured at fair 

value using Level 3 inputs:  

Balance at April 1,  
Change in fair value  
Reclassification of warrants to additional paid-in capital  
Balance at March 31,  

2012 
$ 156,497      
  (119,163 )    
—        
$  37,334      

2011 
$ 334,363    
   (49,590 )  
  (128,276 )  
$ 156,497    

Note 6. Line of Credit  

During October 2010, the Company secured a one-year renewal of the line of credit (the “Line”) for $90,000 which was secured by a 
$90,000 certificate of deposit with a financial institution. On August 23, 2011 the Company paid the Line balance in full. The certificate of 
deposit was closed and the proceeds of $91,443 were recorded as cash and cash equivalents in September 2011. All borrowings under the Line 
bore variable interest based on either the prime rate plus 1.5% per annum or 5.0%, whichever was higher. The Company utilized the funds 
advanced from the Line for capital equipment purchases to support the commercialization of the Company’s CryoPort Express  Dry Shipper. As 
of March 31, 2011, the outstanding balance of the Line was $90,388, including accrued interest of $388. No funds were drawn against the Line 
during the years ended March 31, 2012 and 2011. The Company recorded interest expense of $1,725 and $4,563 for the years ended March 31, 
2012 and 2011, respectively, related to the Line.  

® 

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Note 7. Related Party Transactions  

Related Party Notes Payable  

As of March 31, 2012 and 2011, the Company had aggregate principal balances of $747,500 and $849,500, respectively, in outstanding 

unsecured indebtedness owed to four related parties, including former members of the Company’s board of directors, representing working 
capital advances made to the Company from February 2001 through March 2005. These notes bear interest at the rate of 6% per annum and 
provide for aggregate monthly principal payments which began April 1, 2006 of $2,500, and which increased by an aggregate of $2,500 every 
nine months to a maximum of $10,000 per month. As of March 31, 2012, the aggregate principal payments totaled $8,000 per month. Any 
remaining unpaid principal and accrued interest is due at maturity on various dates through March 1, 2015.  

Related-party interest expense under these notes was $48,036 and $57,156 for the years ended March 31, 2012 and 2011, respectively. 

Accrued interest related to these notes, which is included in related party notes payable in the accompanying consolidated balance sheets, 
amounted to $723,948 and $675,912 as of March 31, 2012 and 2011, respectively.  

Scheduled maturities of related party notes payable, including accrued interest, as of March 31, 2012 are as follows:  

Years Ending March 31:  
2013  
2014  
2015  

96,000    
96,000    
  1,279,448    
$ 1,471,448    

Note Payable to Former Officer  

In August 2006, Peter Berry, the Company’s former Chief Executive Officer, agreed to convert his deferred salaries to a long-term note 
payable. Under the terms of this note, the Company began to make monthly payments of $3,000 to Mr. Berry in January 2007. Interest of 6% per 
annum on the outstanding principal balance of the note began to accrue on January 1, 2008. The note and a portion of the accrued interest were 
paid in March 2010 and the remaining accrued interest of $11,996 was paid in full in August 2010. Interest expense related to this note was 
$11,996 for the year ended March 31, 2011.  

Advisory Services Agreement with Former Officer  

On March 7, 2011 the Company entered into a one-year Advisory Services Agreement with Marc Grossman M.D. to provide strategic 

business advisory services including identifying and introducing customers, advising on sales and marketing plans and providing financial 
advice. Dr. Grossman is a former officer of the Company and is one of the four related parties to which CryoPort has an outstanding unsecured 
debt obligation. For these services, Dr. Grossman was paid a fee of $125,000, which was amortized over the term of the agreement, and issued a 
warrant to purchase 200,000 shares of the Company’s common stock at an exercise price of $0.77 per share and vested upon issuance (see Note 
12).  

Consulting Agreement with Officer  

On July 29, 2009, the Board of Directors of the Company appointed Ms. Catherine M. Doll, a consultant, to the offices of Chief Financial 

Officer, Treasurer and Assistant Corporate Secretary, which became effective on August 20, 2009. Ms. Doll resigned the offices of Chief 
Financial Officer, Treasurer and Assistant Corporate Secretary on June 27, 2011, effective immediately following the Company’s filing of its 
Form 10-K for the fiscal year ended March 31, 2011. Ms. Doll is the owner and chief executive officer of The Gilson Group, LLC. The  

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Gilson Group, LLC provides financial and accounting consulting services, including SEC and financial reporting, budgeting and forecasting to 
the Company. Related-party consulting fees for all services provided by The Gilson Group, LLC, were approximately $76,000 and $438,000 for 
the years ended March 31, 2012 and 2011, respectively.  

Note 8. Convertible Debentures Payable  

The Company’s convertible debenture principal balances are shown below:  

October 2007 Debentures  
Debt discount  
Total convertible debentures, net  
Short-term:  
Current portion of convertible debentures payable and accrued interest, net of discount of $8,843 in 2012 and 

$197,226 in 2011, respectively  

Long-term:  
Convertible debentures payable, net of current portion and discount of $0 in 2012 and $8,842 in 2011, 

respectively  

Total convertible debentures, net  

March 31,  
2012 
$ 334,168      
(8,843 )    
$ 325,325      

March 31,  
2011 
$ 2,607,196    
   (206,068 )  
$ 2,401,128    

$ 337,902      

$ 1,979,402    

   —        
$ 337,902      

   421,726    
$ 2,401,128    

During the years ended March 31, 2012 and 2011, the Company recognized an aggregate of $197,225 and $522,041 in interest expense, 

respectively, due to amortization of debt discount related to the warrants and beneficial conversion features associated with the Company’s 
outstanding convertible debentures. During the year ended March 31, 2012, the Company recorded interest expense of $122,825 related to the 
stated interest associated with the Debentures, of which $12,577 is included in accrued interest in the accompanying consolidated balance sheet.  

October 2007 and May 2008 Debentures  

The Company issued convertible debentures in October 2007 (the “October 2007 Debentures”) and in May 2008 (the “May 2008 

Debentures,” and together with the October 2007 Debentures, the “Debentures”). The Debentures were issued to four institutional investors and 
had an outstanding principal balance of $334,168 and $2,607,196 as of March 31, 2012 and 2011, respectively. In addition, in October 2007 and 
May 2008, the Company issued to these institutional investors warrants to purchase, as of March 31, 2012, an aggregate of 3,055,097 shares of 
the Company’s common stock (the “Debenture Warrants”). As collateral to secure our repayment obligations to the holders of the Debentures we 
have granted such holders a first priority security interest in generally all of our assets, including our intellectual property.  

The October 2007 Debentures are convertible into shares of the Company’s common stock at a price of $3.00 per and share bear interest at 

8% per annum. The Company has been obligated to make principal or additional interest payments since March 1, 2011 with respect to the 
outstanding balances of the October 2007 Debentures. The Company is making monthly principal payments of $200,000 and quarterly interest 
payments. The October 2007 Debentures are scheduled to be fully repaid by June 2012.  

As of March 31, 2011, the May 2008 Debentures were paid in full.  

Because the consummation of the private placement in February 2012 would have triggered defaults under the Company’s October 2007 
Debentures, prior to the initial close of the private placement, the Company obtained a waiver from the holders of the October 2007 Debentures 
with respect to such defaults and their  

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consent to the private placement. In consideration for such waiver and consent, the Company, at the initial close, issued to the holders of the 
October 2007 Debentures warrants to purchase an aggregate of 280,000 shares of the Company’s common stock at an exercise price of $0.69 per 
share. The warrants have terms identical to the warrants issued to the investors in the private placement (see Note 10).  

Note 9. Derivative Liabilities  

In accordance with current accounting guidance, certain of the Company’s outstanding warrants to purchase shares of common stock and 
embedded conversion features in convertible notes payable are treated as derivatives because these instruments have reset or ratchet provisions 
in the event the Company raises additional capital at a lower price, among other adjustments. As such, the fair value of these common stock 
purchase warrants and embedded conversion features were treated as derivative liabilities since their date of issuance or modification. Changes 
in fair value are recorded as non-operating, non-cash income or expense at each reporting date. If the fair value of the derivatives is higher at the 
subsequent balance sheet date, the Company will record a non-operating, non-cash charge. If the fair value of the derivatives is lower at the 
subsequent balance sheet date, the Company will record non-operating, non-cash income. As of March 31, 2012 and 2011 the Company had 
derivative warrant liabilities of $37,334 and $156,497, respectively.  

During the year ended March 31, 2011, it was determined that the anti-dilution provisions contained in the warrants issued in connection 

with the private placement debentures in fiscal year 2010 were no longer afforded treatment as a derivative liability due to the equity financing in 
February 2010, thus the Company reclassified the derivative liability of $128,276 to additional paid-in capital.  

During the years ended March 31, 2012 and 2011, the Company issued an aggregate of 10,289 and 36,371 warrants to purchase shares of 
the Company’s common stock, respectively, pursuant to the anti-dilution provisions contained in the warrant agreements which were previously 
issued to various placement agents in lieu of cash fees. On August 20, 2010, in connection with the August 2010 private placement closing, the 
exercise price of the warrants was reduced from $3.30 per share to $3.20 per share and the Company issued an additional 4,073 warrants. On 
February 4, 2011, in connection with the February 2011 private placement, the exercise price of the warrants was reduced from $3.20 per share 
to $2.81 per share and the Company issued an additional 18,657 warrants. On February 14, 2011, in connection with the February 2011 private 
placement, the exercise price of the warrants was reduced from $2.81 per share to $2.58 per share and the Company issued an additional 13,641 
warrants. On February 22, February 28, and March 7, 2012, in connection with the February 2012 private placement, the Company issued an 
additional 6,721, 2,843 and 725 warrants respectively, and the exercise price of the warrants was reduced from $2.58 per share to $2.48 per 
share, $2.48 per share to $2.44 per share and $2.44 per share to $2.43 per share, respectively. Since the exercise price of the warrants is subject 
to additional adjustment in the event the Company issues dilutive equity securities, as described in the original warrant agreements, the warrants 
are accounted for as derivative liabilities.  

During the years ended March 31, 2012 and 2011, the Company recognized aggregate gains of $119,163 and $49,590, respectively, due to 
the change in fair value of its derivative instruments. See Note 5 for the components of changes in derivative liabilities. The Company’s common 
stock purchase warrants do not trade in an active securities market, and as such, the Company estimated the fair value of these warrants using 
Black-Scholes using the following assumptions:  

Expected dividends  
Expected term (in years)  
Risk-free interest rate  
Expected volatility  

March 31,  
2012 
—   
2.01 – 2.81 
0.33% – 0.81% 
124% – 132% 

March 31,  
2011 
—   
3.01 – 4.22 
0.64% – 1.79% 
128% – 189% 

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Historical volatility was computed using daily pricing observations for recent periods that correspond to the remaining term of the 
warrants, which had an original term of five years from the date of issuance. The expected life is based on the remaining term of the warrants. 
The risk-free interest rate is based on U.S. Treasury securities with a maturity corresponding to the remaining term of the warrants.  

Note 10. Stockholders’ Equity  

Preferred Stock  

On September 22, 2011, the Company’s stockholders approved an amendment to the Company’s Amended and Restated Articles of 

Incorporation to authorize a class of undesignated or “blank check” preferred stock, which had previously been approved by the Company’s 
Board of Directors on July 19, 2011, consisting of 2,500,000 shares at $0.001 par value per share. Shares of preferred stock may be issued in one 
or more series, with such rights, preferences, privileges and restrictions as shall be fixed by the Company’s Board of Directors.  

Common Stock  

The Company’s authorized capital consists of 250,000,000 shares of common stock, $0.001 par value per share. As of March 31, 2012 and 

2011, 37,760,628 and 27,504,604 shares of common stock were issued and outstanding, respectively.  

Fiscal Year 2011 Activity  

In April 2010, the Company issued 13,636 shares of unrestricted common stock in lieu of fees paid to various consultants for services 
incurred in fiscal year 2010 pursuant to the Company’s Form S-8 filed on April 27, 2010. These shares were issued at a value of $1.76 per share 
for a total cost of $23,999 which was included in accounts payable and accrued expenses and selling, general and administrative expense as of 
and for the year ended March 31, 2010.  

During August 2010, the Company closed its first round of a private placement financing to institutional and accredited investors resulting 

in the issuance of units consisting of 4,699,550 shares of common stock and warrants to purchase 4,699,550 shares of common stock at an 
exercise price of $0.77 per share, for gross cash proceeds of $3,289,701 and net cash proceeds of $2,990,953. Each unit consisting of one share 
of common stock, together with one warrant to purchase one share of common stock, was priced at $0.70. Certain investors that had invested in 
the Company’s public offering that was completed on February 25, 2010 were issued additional warrants with the same terms to purchase an 
aggregate of 448,333 shares of common stock in connection with this private placement. The fair market value of the warrants issued to prior 
investors of $307,794 was based on Black-Scholes and recorded to additional paid-in capital and offset against the proceeds of the financing 
with no net effect on equity. In connection with the closing of this first round of financing, the Company paid a 7% fee to the placement agents 
of $230,279 and issued warrants to purchase 657,940 shares of the Company’s common stock, at an exercise price of $0.77, which are 
immediately exercisable and have a term of five years. The fair market value of the warrants issued to the placement agents of $449,938 was 
based on Black-Scholes and was recorded to additional paid-in capital and offset against the proceeds of the financing with no net effect on 
equity. The Company incurred additional legal and accounting fees of $36,207 in connection with the first round of financing.  

During September 2010, the Company received a $29,067 credit for financing fees which were reclassed to additional paid-in capital 

during the year ended March 31, 2010, and offset against the proceeds related to the February 2010 public offering.  

On October 14, 2010, the Company closed on its second round of a private placement financing of its securities to certain institutional and 

accredited investors that commenced in August 2010. In connection with the second closing of the private placement financing, the Company 
received aggregate gross proceeds of $583,001  

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and net cash proceeds of $416,726. The investors purchased an aggregate of 832,868 units priced at $0.70 per unit, with each unit consisting of 
one share of common stock and one warrant to purchase one share of common stock at an exercise price of $0.77 per share. The warrants are 
immediately exercisable and have a term of five years. In connection with this second round of financing, the Company paid a 7% fee to the 
placement agents of $40,811 and issued a warrant to purchase 116,602 shares of Common Stock at an exercise price of $0.77 per share, which 
are immediately exercisable and have a term of five years. The fair market value of the warrants issued to the placement agents of $85,719 was 
based on Black-Scholes and was recorded to additional paid-in capital and offset against the proceeds of the financing with no net effect on 
equity. The Company incurred additional legal and accounting fees of $122,964 in connection with the second round of financing.  

Pursuant to the Registration Rights Agreement, on October 19, 2010, the Company filed a registration statement on Form S-1 with the 

Securities and Exchange Commission (“SEC”) registering the resale of the 12,287,711 shares of common stock issued to the investors that 
participated in both the first closing of the private placement during August 2010 and the second closing of the private placement during October 
2010, and the shares of common stock underlying the warrants issued to the investors and placement agents in both closings. The registration 
statement was declared effective by the SEC on December 29, 2010.  

During January 2011, the holders of the October 2007 Debentures converted $200,000 principal into 66,666 shares of the Company’s 

common stock at a conversion price of $3.00 per share per the terms of the Debentures.  

On February 4, 2011, the Company consummated the first closing of a private placement to accredited investors resulting in the issuance of 
units consisting of 6,335,318 shares of common stock and warrants to purchase 6,335,318 shares of common stock at an exercise price of $0.77, 
for gross cash proceeds of $4,434,722. On February 14, 2011, the Company completed the second closing of this same private placement 
resulting in the issuance of units consisting of 7,026,771 shares of common stock and warrants to purchase 7,026,771 shares of common stock at 
an exercise price of $0.77, for gross cash proceeds of $4,918,740. In both closings, each unit consisting of one share, together with one warrant 
to purchase one share, was priced at $0.70 for aggregate gross proceeds of $9,353,462. Aggregate net proceeds which reflect placement agent 
fees, legal and accounting fees were $8,041,880. In addition, as part of the compensation to the selling agents, warrants to purchase 2,393,826 
shares of common stock were issued to the agents. The warrants issued to the investors and selling agents are immediately exercisable and have 
a term of five years. The fair market value of the warrants issued to the placement agents of $2,153,397 was based on Black-Scholes and was 
recorded to additional paid-in capital and offset against the proceeds of the financing with no net effect on equity. The Company was obligated 
to file a registration statement with the SEC registering the resale of the shares of common stock issued to the investors and the shares of 
common stock underlying the warrants issued to the investors within ninety (90) days following the close of the transaction.  

Pursuant to the Registration Rights Agreement, on April 22, 2011, the Company filed a registration statement on Form S-1 with the SEC 

registering the resale of 40,943,178 shares of common stock issued to the investors that participated in the February 2011 private placement, the 
private placement which occurred during August 2010 and October 2010, the shares of common stock underlying the warrants issued to the 
investors and placement agents in both private placements and the underlying shares of common stock which will be issued upon exercise of the 
publicly traded warrants that were issued as part of the public offering of units the occurred in February 2010.  

During the year ended March 31, 2011, the Company reclassified $128,276 of derivative liability related to the private placement warrants 

issued in fiscal year 2010 to additional paid-in capital (see Note 9).  

During the year ended March 31, 2011, the Company issued 274,500 shares of common stock upon the exercise of warrants at an exercise 

price of $0.77 per share and 4,594 shares of common stock upon the exercise of options at an exercise price of $0.40 per share.  

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During the year ended March 31, 2011, the Company issued 114,061 shares of common stock upon the cashless exercise of a total of 

209,525 warrants at an exercise price of $0.77 per share.  

During the year ended March 31, 2011, stock options to purchase 362,232 shares of the Company’s common stock were issued to the 
Company’s former Chief Executive Officer in lieu of a cash bonus of $216,000 for fiscal year 2010. As of and for the year ended March 31, 
2010, this bonus was included in accrued compensation and related expenses and selling, general and administrative expenses.  

Fiscal Year 2012 Activity  

In February and March 2012, the Company conducted a private placement of units totaling 9,477,554 at a purchase price of $0.55 per unit 
(the “February 2012 Private Placement”) for total proceeds of $4,640,400, net of offering costs of $572,255. Each unit consisted of one share of 
common stock and one warrant to purchase one share of common stock at an exercise price of $0.69 per share. Each warrant is fully exercisable 
six months from the date of issuance for a period of five years from the date of issuance. All units were purchased by accredited or institutional 
investors under three closings; first closing of 6,795,572 units on February 22, 2012, second closing of 2,032,937 units on February 28, 2012 and 
a third closing of 649,045 units on March 7, 2012.  

Craig-Hallum Capital Group LLC acted as the lead placement agent, and Emergent Financial Group, Inc. and Maxim Group LLC served as 

co-placement agents in this transaction and received, in the aggregate, commissions of $450,245, plus reimbursement of out-of-pocket expenses 
of $43,530, and 248,375 warrants to purchase shares of the Company’s common stock at an exercise price of $0.69 per share. The warrants have 
terms identical to the warrants issued to the investors in the February 2012 Private Placement. The fair value of the warrants issued to the 
placement agents of $152,579 was based on Black-Scholes and was recorded to additional paid-in capital and offset against the proceeds of the 
financing with no net effect on equity. The Company also incurred $78,480 of issuance costs including legal, accounting and printer fees related 
to this transaction. The placement agent expenses and issuance costs have been offset against the proceeds of the financing.  

Because the consummation of the February 2012 Private Placement would have triggered defaults under the Company’s October 2007 
Debentures, prior to the initial close of the February 2012 Private Placement, the Company obtained a waiver from the holders of the October 
2007 Debentures with respect to such defaults and their consent to the February 2012 Private Placement. In consideration for such waiver and 
consent, the Company, at the initial close, issued to the holders of the October 2007 Debentures warrants to purchase an aggregate of 280,000 
shares of the Company’s common stock at an exercise price of $0.69 per share. The warrants have terms identical to the warrants issued to the 
investors in the February 2012 Private Placement. The fair value of the warrants issued to the convertible debenture holders of $156,999 was 
based on Black-Scholes and was recorded to additional paid-in capital and interest expense in the accompanying consolidated statement of 
operations.  

During the year ended March 31, 2012, the Company received cash proceeds of $571,630 from the exercise of warrants to purchase 

742,380 shares of the Company’s common stock at an average exercise price of $0.77 per share.  

During the year ended March 31, 2012, the Company issued 36,090 shares of common stock upon the cashless exercise of a total of 85,714 

warrants at an exercise price of $0.77 per share.  

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Warrants  

A summary of the Company’s warrant activity (other than those warrants issued to the Company’s employees, officers, directors and 

related consultants presented in Note 11 below) and related information during the 2012 fiscal year follows:  

Outstanding at April 1, 2011  
Granted  
Exercised  
Forfeited  
Expired  
Outstanding at March 31, 2012  
Exercisable  

Number of Shares      
   27,509,814      
   10,184,562      
(778,470 )    
(49,624 )    
(34,634 )    
   36,831,648      
   26,693,349      

Weighted-  
Average  
Exercise Price       
1.27       
$ 
0.69       
$ 
0.77       
$ 
0.77       
$ 
2.61       
$ 
1.12       
$ 
1.29       
$ 

Remaining 
Contractual 

Life (Years)       

Aggregate  
Intrinsic  
Value 

$ 

  434,266    

3.92       
3.54       

$  —      
$  —      

The following summary information reflects outstanding warrants to purchase shares of the Company’s common stock as of March 31, 

2012 and other related details:  

Year of Grant  
(as of March 31) 
2008  
2009  
2010  
2011  
2012  

Note 11. Stock Compensation Plan  

Plan Descriptions  

Warrants Outstanding 

Exercise Price 
$ 3.30 – $10.10      
$ 2.81 – $  8.50       
$ 1.91 – $  5.10       
$ 0.77 – $  2.43       
$ 0.69 – $  1.38       

Number  

Outstanding        
   1,752,257       
659,881       
   2,769,219       
  21,465,729       
  10,184,562       
  36,831,648       

Remaining 
Contractual 

Life (Years)   
2.72    
2.64    
2.80    
3.73    
4.80    

The Company maintains three stock incentive plans, the 2002 Stock Incentive Plan (the “2002 Plan”), the 2009 Stock Incentive Plan (the 

“2009 Plan”) and the 2011 Stock Incentive Plan (the “2011 Plan”). The 2002 Plan provides for grants of incentive stock options and nonqualified 
options to employees, directors and consultants of the Company to purchase the Company’s shares at the fair value, as determined by 
management and the board of directors, of such shares on the grant date. The options are subject to various vesting conditions and generally vest 
over a three-year period beginning on the grant date and have seven to ten-year term. The 2002 Plan also provides for the granting of restricted 
shares of common stock subject to vesting requirements. The Company is authorized to issue up to 500,000 shares under this plan and has 
268,750 shares available for future issuances as of March 31, 2012.  

On October 9, 2009, the Company’s stockholders approved and adopted the 2009 Plan, which had previously been approved by the 
Company’s Board of Directors on August 31, 2009. The 2009 Plan provides for the grant of incentive stock options, nonqualified stock options, 
restricted stock rights, restricted stock, performance share units, performance shares, performance cash awards, stock appreciation rights, and 
stock grant awards (collectively, “Awards”) to employees, officers, non-employee directors, consultants and independent contractors of the 
Company. The 2009 Plan also permits the grant of awards that qualify for the “performance-based compensation” exception to the $1,000,000 
limitation on the deduction of compensation  

F-24  

   
   
   
  
   
 
  
   
   
     
   
   
   
  
   
   
  
   
   
  
   
   
    
    
  
  
   
   
   
  
   
    
    
  
  
    
    
  
   
    
    
  
   
    
    
  
   
  
   
    
    
  
  
    
    
  
   
    
    
  
   
    
    
  
  
   
  
   
      
 
   
  
   
  
  
   
  
   
  
   
  
   
   
    
    
  
   
   
   
   
   
    
    
  
   
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imposed by Section 162(m) of the Internal Revenue Code. A total of 1,200,000 shares of the Company’s common stock are authorized for the 
granting of Awards under the 2009 Plan. The number of shares available for future Awards, as well as the terms of outstanding Awards, is 
subject to adjustment as provided in the 2009 Plan for stock splits, stock dividends, recapitalizations and other similar events. Awards may be 
granted under the 2009 Plan until the sooner of October 9, 2019 or until all shares available for Awards under the 2009 Plan have been 
purchased or acquired. The Company is authorized to issue up to 1,200,000 shares under this plan and as of March 31, 2012, the Company has 
23,491 shares available for future Awards under the 2009 Plan.  

On September 22, 2011, the Company’s stockholders approved and adopted the 2011 Plan, which had previously been approved by the 
Company’s Board of Directors on July 19, 2011. The 2011 Plan provides for the grant of Awards to employees, officers, non-employee directors 
and consultants of the Company. The Company’s Compensation Committee has the authority to determine the type of Award as well as the 
amount, terms and conditions of each Award under the 2011 Plan, subject to the limitations and other provisions of the 2011 Plan. A total of 
2,300,000 shares of the Company’s common stock are authorized for the granting of Awards under the 2011 Plan. The number of shares 
available for Awards, as well as the terms of outstanding Awards, is subject to adjustment as provided in the 2011 Plan for stock splits, stock 
dividends, recapitalizations and other similar events. Awards may be granted under the 2011 Plan until September 21, 2021 or until all shares 
available for Awards under the 2011 Plan have been purchased or acquired unless the stockholders of the Company vote to approve an extension 
of the 2011 Plan prior to such expiration date. As of March 31, 2012, the Company has 2,293,527 shares available for future Awards under the 
2011 Plan.  

In addition to the stock options issued pursuant to the Company’s three stock incentive plans, the Company has granted warrants to 

employees, officers, non-employee directors, consultants and independent contractors. The warrants are generally not subject to vesting 
requirements and have ten-year terms.  

As of March 31, 2012, a total of 185,787, 1,162,873 and 6,473 shares of common stock were reserved for issuance upon exercise of 
outstanding stock options under the 2002, 2009 and 2011 Stock Plans, respectively, and a total of 312,855 shares of common stock were 
reserved for issuance upon exercise of outstanding warrants. A summary of the Company’s employee and director stock option and warrant 
activity and related information during the 2012 fiscal year follows:  

Outstanding at April 1, 2011  
Granted  
Exercised  
Canceled  
Outstanding and expected to vest at March 31, 2012  
Exercisable at March 31, 2012  

Weighted-
 Average  
Exercise  
Price 
$  2.65       
$  1.27       
$  —         
$  1.53       
$  2.48       
$  3.03       

Number of  
Shares 
  1,525,896      
   450,000      
—        
   (307,908 )    
  1,667,988      
  1,242,978      

F-25  

Remaining  
Contractual  
Life 

Aggregate 

Intrinsic  
Value 

6.99       
6.36       

$  3,716    
$  3,716    

   
   
  
   
     
      
      
 
  
   
   
   
   
   
  
   
   
   
   
    
    
  
  
   
   
   
  
   
    
    
  
  
    
   
  
   
    
    
  
   
    
    
  
   
  
   
    
    
  
  
    
   
  
   
    
    
  
   
    
    
  
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The following summary information reflects stock options and warrants outstanding, vesting and related details as of March 31, 2012:  

Year of Grant  
(as of March 31) 
2003  
2004  
2005  
2007  
2008  
2009  
2010  
2011  
2012  

Exercise Price 
$10.00 
$6.00 
$0.40 – $6.00    
$2.80 – $10.00    
$7.50 – $10.80    
$5.10 – $10.50    
$4.30 – $8.30    
$0.61 – $1.89    
$0.86 – $1.45    

Stock Options and Warrants Outstanding 
Remaining 
Contractual 

Number  
Outstanding       
5,000       
20,000       
22,200       
   111,335       
88,780       
91,740       
   101,601       
  1,027,332       
   200,000       
  1,667,988       

Life (Years)       
0.67       
1.50       
2.33       
4.44       
5.57       
3.87       
5.06       
7.64       
9.27       

Vested and  
Exercisable    
5,000    
20,000    
22,200    
   111,335    
88,780    
91,740    
   101,601    
   778,130    
24,192    
  1,242,978    

The Company uses Black-Scholes to recognize the value of stock-based compensation expense for all stock-based payment awards. 
Determining the appropriate fair-value model and calculating the fair value of stock-based awards at the grant date requires considerable 
judgment, including estimating stock price volatility, expected option life and forfeiture rates. The Company develops estimates based on 
historical data and market information, which can change significantly over time. Black-Scholes requires the Company to make several key 
judgments including:  

• 

• 

• 

• 

• 

   The expected option term reflects the application of the simplified method set out in Staff Accounting Bulletin No. 107 Share-Based 
Payment (SAB 107), which was issued in March 2005. In December 2007, the SEC released SAB 110, which extends the use of the 
“simplified” method, under certain circumstances, in developing an estimate of expected term of “plain vanilla” share options. 
Accordingly, the Company has utilized the average of the contractual term of the options and the weighted average vesting period for 
all options and warrants to calculate the expected option term.  
   Estimated volatility also reflects the historical volatility pattern of the Company’s share price.  
   The dividend yield is based on the Company’s historical pattern of dividends as well as expected dividend patterns.  
   The risk-free rate is based on the implied yield of U.S. Treasury notes as of the grant date with a remaining term approximately equal 
to the expected term.  
   Estimated forfeiture rate of 0% per year is based on the Company’s historical forfeiture activity of unvested stock options. The 
Company used the following assumptions for stock options and warrants granted during the years ended March 31, 2012 and 2011:  

Risk-free interest rate  
Expected volatility  
Expected life (in years)  
Expected dividend yield  

F-26  

Years Ended March 31,  

2012  
1.15% – 2.87% 
164% – 173% 
5.91 – 7.44 
N/A 

2011  
0.77% – 3.32% 
142% – 179% 
3.50 – 6.48 
N/A 

   
   
   
   
   
   
   
   
  
   
  
   
  
   
   
 
   
   
  
  
  
   
   
  
  
  
   
  
  
  
   
  
   
  
  
  
   
  
  
  
   
  
   
  
   
  
  
   
   
    
    
  
   
   
    
    
  
   
   
   
   
   
    
    
  
   
   
    
    
  
  
  
  
  
  
  
   
  
   
   
   
   
   
   
   
   
   
   
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For the years ended March 31, 2012 and 2011, the weighted-average fair value of the Company’s stock option and warrant grants are as 

follows:  

Grant Year 
March 31, 2012  
March 31, 2011  

Weighted  
Average  
Fair Value of 

Options and 
Warrants 

$ 
$ 

1.24    
0.69    

Granted 
   450,000       
  1,296,832       

There were 450,000 stock options granted to employees and directors during the year ended March 31, 2012, and 1,296,832 stock options 

granted to employees and directors during the year ended March 31, 2011. In connection with the options granted and the vesting of prior 
options and warrants issued to employees and directors, during the years ended March 31, 2012 and 2011, the Company recorded total charges 
of $262,844 and $396,696, respectively, which have been included in selling, general and administrative expenses in the accompanying 
consolidated statements of operations. The Company issues new shares from its authorized shares upon exercise of warrants or options.  

As of March 31, 2012, there was $306,600 of total unrecognized compensation cost, related to non-vested stock options, which is expected 

to be recognized over a remaining weighted average vesting period of 2.35 years.  

There were no employee or director stock options and warrants exercised during the year ended March 31, 2012. The aggregate intrinsic 

value of stock options and warrants exercised during the year ended March 31, 2011 was $4,594.  

Note 12. Equity Instruments Issued to Non-Employees for Acquiring Goods or Services  

During December 2011, the Company issued a warrant to purchase 155,844 shares of the Company’s common stock at an exercise price of 

$0.77 per share and a five year life to a consultant for services to be rendered over two years. The Company recognized $16,112 in expense 
related to this warrant for the year ended March 31, 2012.  

During July 2011, the Company issued a warrant to purchase 10,000 shares of the Company’s common stock at an exercise price of $1.20 
per share and a five year life to a consultant for services to be rendered within one year. The Company recognized $8,297 in expense related to 
this warrant for the year ended March 31, 2012.  

During April 2011, the Company issued a warrant to purchase 2,500 shares of the Company’s common stock at an exercise price of $1.38 

per share and a five year life to a consultant for services to be rendered over three years. The Company recognized $966 in expense related to 
this warrant for the year ended March 31, 2012.  

On March 7, 2011, the Company entered into an Advisory Services Agreement with Marc Grossman M.D. to provide strategic business 

advice for which he was issued a fully-vested warrant to purchase 200,000 shares of the Company’s common stock at an exercise price of $0.77 
per share, in addition to a fee of $125,000. The fair value of this warrant was $302,769 as calculated using Black-Scholes and was recorded as an 
other current asset. For the years ended March 31, 2012 and 2011, the Company recognized $277,538 and $25,231, respectively, in expense 
related to this warrant and is included in selling, general and administrative in the accompanying consolidated statements of operations. As of 
March 31, 2012 and 2011 the remaining amount of $0 and $277,538, respectively, is included in other current assets in the accompanying 
consolidated balance sheets.  

On May 10, 2010, the Company issued warrants to purchase an aggregate of 40,000 shares of the Company’s common stock at an exercise 

price of $1.89 per share and a five year life to a consultant for services rendered through June 2011. The warrants vested as to 20,000 shares of 
common stock upon issuance with a fair  

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value of $36,090 and as to 20,000 shares of common stock upon attainment of certain deliverables and were valued accordingly at each interim 
reporting date until the deliverables were completed on June 8, 2011. Upon completion of the deliverable, the fair value was $12,937 which 
resulted in the Company reversing $6,666 in expense previously recorded in fiscal 2011. The Company recognized an aggregate of $55,693 in 
expense related to these warrants for the year ended March 31, 2011 and is included in selling, general and administrative expenses in the 
accompanying consolidated statement of operations.  

Note 13. Commitments and Contingencies  

Lease Commitments  

We currently lease two facilities, with approximately 11,900 square feet of corporate, research and development, and warehouse facilities, 

located in Lake Forest, California (“Lake Forest Facility”) and approximately 4,100 square feet of corporate facilities located in San Diego, 
California (“San Diego Facility”). In June 2010, the Company entered into a third amendment to the Lake Forest Facility lease and extended the 
lease for sixty months commencing July 1, 2010 with a right to cancel the lease with a minimum of 120 day written notice at any time after 
December 31, 2012 and adjusted the base lease payments to a range over the life of the agreement of $7,010 per month to $8,911 per month, plus 
operating expenses. On April 11, 2011, the Company entered into an office service agreement with Regis Management Group, LLC (Lessor) for 
six (6) executive offices in San Diego which the Company terminated effective December 31, 2011. Aggregate base lease payments for these 
offices were approximately $9,250 per month. On November 28, 2011, the Company entered into a lease agreement for the San Diego Facility 
for a thirty six month period ending December 31, 2014. Base lease payments range over the life of the agreement of $8,621 per month to $9,442 
per month, plus operating expenses.  

Total rental expense was approximately $235,000 and $170,000 for the years ended March 31, 2012 and 2011, respectively.  

Future annual minimum payments under operating leases are as follows:  

Years Ending March 31: 
2013  
2014  
2015  
2016  
2017  

$ 187,443    
  212,949    
  192,966    
   26,733    
   —      
$ 620,091    

Consulting and Engineering Services  

Effective November 1, 2010, the Company entered into a Second Amendment to Master Consulting and Engineering Services Agreement 

(the “Second Amendment”) with KLATU Networks, LLC (“KLATU”), which amended the Master Consulting and Engineering Services 
Agreement between the parties dated as of October 9, 2007 (the “Agreement”), as amended by the First Amendment to Master Consulting and 
Engineering Services Agreement between the parties dated as of April 23, 2009. The parties entered into the Second Amendment to clarify their 
mutual intent and understanding that all license rights granted to the Company under the Agreement, as amended, shall survive any termination 
or expiration of the Agreement. In addition, in recognition that the Company has paid KLATU less than the market rate for comparable services, 
the Second Amendment provides that if the Company terminates the Agreement without cause, which the Company has no intention of doing, or 
liquidates, KLATU shall be entitled to receive additional consideration for its services provided from the commencement of the Agreement 
through such date of termination, which additional compensation shall not be less than $2 million plus two times the “cost of work” (as defined 
in the Agreement). Any such additional compensation would be payable in three equal installments within 12 months following the date the 
amount of such additional compensation is determined.  

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The Master Consulting and Engineering Services Agreement dated October 9, 2007, as amended on April 23, 2009 and November 1, 2010, 
between CryoPort, Inc. and KLATU Networks, LLC provides a framework for KLATU to provide services to CryoPort. The agreement provides 
for one year terms ending on December 31 of each year, but it automatically renews for one year periods unless otherwise terminated. CryoPort 
can terminate the agreement upon 30 days notice. If CryoPort terminates the agreement, it has to pay KLATU a termination fee that will not be 
less than $2,000,000 plus two times the cost of work (as defined in the agreement) performed by KLATU under the agreement. Consulting fees 
for services provided by KLATU were $494,408 and $464,458 for the years ended March 31, 2012 and 2011, respectively.  

Litigation  

The Company may become a party to product litigation in the normal course of business. The Company accrues for open claims based on 
its historical experience and available insurance coverage. In the opinion of management, there are no legal matters involving the Company that 
would have a material adverse effect upon the Company’s financial condition or results of operations.  

Indemnities and Guarantees  

The Company has made certain indemnities and guarantees, under which it may be required to make payments to a guaranteed or 
indemnified party, in relation to certain actions or transactions. The guarantees and indemnities do not provide for any limitation of the 
maximum potential future payments the Company could be obligated to make. Historically, the Company has not been obligated nor incurred 
any payments for these obligations and, therefore, no liabilities have been recorded for these indemnities and guarantees in the accompanying 
consolidated balance sheets.  

The Company indemnifies its directors, officers, employees and agents, as permitted under the laws of the States of California and Nevada. 

In connection with its facility leases, the Company has indemnified its lessors for certain claims arising from the use of the facilities. The 
duration of the guarantees and indemnities varies, and is generally tied to the life of the agreement.  

In connection with the Company’s agreement with FedEx pursuant to which the Company leases to FedEx its cryogenic shippers, the 

Company has agreed to indemnify and hold harmless FedEx, its directors, officers, employees and agents from and against any and all claims, 
demands, causes of action, losses, damages, judgments, injuries and liabilities, including payment of attorney’s fees. In addition, the Company 
has agreed to indemnify, defend and hold harmless FedEx, its Affiliates (including the corporate patent company), directors, officers, employees 
and agents from and against any and all Claims by third parties based on an allegation that the use of the Company’s shippers infringes on any 
United States or foreign intellectual property right of such third parties, including any potential royalty payments and other costs and damages, 
reasonable attorneys’ fees and out-of-pocket expenses reasonably incurred by FedEx. The duration of these indemnities survive the termination 
or expiration of the agreement.  

Note 14. Income Taxes  

Significant components of the Company’s deferred tax assets as of March 31, 2012 and 2011 are shown below:  

Deferred tax asset:  

Net operating loss carryforward  
Research credits  
Expenses recognized for granting of options and warrants  
Accrued expenses and reserves  
Valuation allowance  

F-29  

2012 

2011 

$ 11,536,000      
32,000      
   1,046,000      
(25,000 )    
  (12,589,000 )    
—        
$ 

$ 8,661,000    
28,000    
927,000    
41,000    
  (9,657,000 )  
—      
$ 

   
   
  
   
     
  
   
  
   
   
  
  
   
  
   
  
  
   
   
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
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Based on the weight of available evidence, the Company’s management has determined that it is more likely than not that the net deferred 

tax assets will not be realized. Therefore, the Company has recorded a full valuation allowance against the net deferred tax assets. The 
Company’s income tax provision consists of state minimum taxes.  

The income tax provision differs from that computed using the federal statutory rate applied to income before taxes as follows:  

Computed tax benefit at federal statutory rate  
State tax, net of federal benefit  
Warrant MTM Adjustment  
Interest Expense  
Permanent items and other  
Valuation allowance  

2012 
$ (2,662,000 )    
(426,000 )    
(41,000 )    
163,000      
35,600      
   2,932,000      
1,600      
$ 

2011 
$ (2,091,000 )  
(307,000 )  
(17,000 )  
203,000    
   4,422,600    
  (2,209,000 )  
1,600    
$ 

At March 31, 2012, the Company has federal and state net operating loss carryforwards of approximately $29,044,000 and $28,452,000 

which will begin to expire in 2020 and 2012, respectively, unless previously utilized. At March 31, 2012, the Company has federal and 
California research and development tax credits of approximately $16,000 and $15,000, respectively. The federal research tax credit begins to 
expire in 2026 unless previously utilized and the California research tax credit has no expiration date.  

Utilization of the net operating loss and research and development carryforwards might be subject to a substantial annual limitation due to 
ownership change limitations that may have occurred or that could occur in the future, as required by Section 382 of the Internal Revenue Code 
of 1986, as amended (the “Code”), as well as similar state and foreign provisions. These ownership changes may limit the amount of NOL and 
R&D credit carryforwards that can be utilized annually to offset future taxable income and tax, respectively. In general, an “ownership change” 
as defined by Section 382 of the Code results from a transaction or series of transactions over a three-year period resulting in an ownership 
change of more than 50 percentage points of the outstanding stock of a company by certain stockholders or public groups. Since the Company’s 
formation, the Company has raised capital through the issuance of capital stock on several occasions which, combined with the purchasing 
stockholders’ subsequent disposition of those shares, may have resulted in such an ownership change, or could result in an ownership change in 
the future upon subsequent disposition.  

The Company has not completed a study to assess whether an ownership change has occurred. If the Company has experienced an 
ownership change, utilization of the NOL or R&D credit carryforwards would be subject to an annual limitation under Section 382 of the Code, 
which is determined by first multiplying the value of the Company’s stock at the time of the ownership change by the applicable long-term, tax-
exempt rate, and then could be subject to additional adjustments, as required. Any limitation may result in expiration of a portion of the NOL or 
R&D credit carryforwards before utilization. Further, until a study is completed and any limitation is known, no amounts are being considered as 
an uncertain tax position or disclosed as an unrecognized tax benefit. Due to the existence of the valuation allowance, future changes in the 
Company’s unrecognized tax benefits will not impact its effective tax rate. Any carryforwards that will expire prior to utilization as a result of 
such limitations will be removed from deferred tax assets with a corresponding reduction of the valuation allowance.  

F-30  

   
   
  
   
     
  
   
   
  
  
   
  
  
   
  
  
   
  
   
   
   
    
  
  
    
    
  
   
   
   
    
  
  
    
    
  
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Note 15. Quarterly Results of Operations (unaudited)  

The following table sets forth a summary of our unaudited quarterly operating results for each of the last eight quarters in the period ended 

March 31, 2012. This data has been derived from our unaudited consolidated interim financial statements which, in our opinion, have been 
prepared on substantially the same basis as the audited consolidated financial statements contained elsewhere in this report and include all 
normal recurring adjustments necessary for a fair presentation of the financial information for the periods presented. These unaudited quarterly 
results should be read in conjunction with our consolidated financial statements and notes thereto included elsewhere in this report. The 
operating results in any quarter are not necessarily indicative of the results that may be expected for any future period (in thousands except 
earnings per share).  

Mar. 31,  
2012 

Dec. 31,  
2011 

Sept. 30,  
2011 

June 30,  
2011 

Mar. 31,  
2011 

Quarter Ended 

Dec. 31,  
2010 

Sept. 30,  
2010 

June 30, 
2010 

Revenues:  
Cost of revenues  
Gross loss  
Research and development  
Selling, general and administrative  
Total operating expenses  
Loss from operations  
Other expense, net  
Loss before income taxes  
Income taxes  
Net loss  
Net loss per common share: Basic  
Weighted average common shares outstanding:    
Basic  
Diluted  

    $ 

177       $ 
330      
(153 )    
145      
   1,173      
   1,318      
   (1,471 )    
(198 )    
   (1,669 )    
   —        

unaudited 
124       $  152    
124       $ 
395    
378      
355      
(243 )  
(254 )    
(231 )    
122    
115      
101      
943    
   1,114      
   1,628      
   1,065    
   1,229      
   1,729      
  (1,308 )  
   (1,483 )    
   (1,960 )    
(19 )  
(27 )    
(92 )    
  (1,327 )  
   (1,510 )    
   (2,052 )    
2    
   —        
2      
    $ (1,669 )     $ (2,080 )     $ (2,030 )     $ (2,054 )     $ (1,857 )     $ (1,457 )     $ (1,510 )     $ (1,329 )  
   (0.16 )  

111       $ 
364      
(253 )    
125      
   1,564      
   1,689      
   (1,942 )    
(88 )    
   (2,030 )    
   —        

100       $ 
257      
(157 )    
105      
   1,081      
   1,186      
   (1,343 )    
(114 )    
   (1,457 )    
   —        

144       $ 
345      
(201 )    
121      
   1,740      
   1,861      
   (2,062 )    
(18 )    
   (2,080 )    
   —        

100       $ 
274      
(174 )    
107      
   1,182      
   1,289      
   (1,463 )    
(394 )    
   (1,857 )    
   —        

(0.15 )    

(0.06 )    

(0.07 )    

(0.07 )    

(0.11 )    

(0.07 )    

(0.09 )    

  32,014      
  32,014      

  28,247      
  28,247      

  27,967      
  27,967      

  27,690      
  27,690      

  21,346      
  21,346      

  13,565      
  13,565      

  10,269      
  10,269      

   8,146    
   8,146    

Note 16. Subsequent Events  

Effective April 5, 2012, Larry G. Stambaugh resigned as the Chief Executive Officer and Chairman of the Board of the Company and as a 
member of the Company’s Board of Directors. The Company also entered into a Separation Agreement and General Release of All Claims (the 
“Release Agreement”) with Mr. Stambaugh on April 5, 2012, that governs the terms of his departure and that provided for a mutual release 
between the Company and Mr. Stambaugh and for the following:  

•   The Company to pay Mr. Stambaugh a severance amount equal to $180,000 in a lump sum within ten  
(10) days after receipt of the Release Agreement; and 

• 

   The exercise period of the two stock options granted to Mr. Stambaugh on September 10, 2010, with exercise prices of $0.66 per 
share, was extended for a period of five (5) years from April 5, 2012 as to those underlying shares of common stock vested as of 
April 5, 2012, which amount to 362,232 and 210,000 shares of the Company’s common stock, respectively.  

F-31  

   
   
   
   
  
   
  
  
   
     
     
     
     
     
     
     
  
  
   
  
     
  
     
  
     
     
  
     
  
     
  
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
  
  
  
  
  
  
  
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
  
  
  
  
  
  
  
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
  
  
  
  
  
  
  
  
   
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
   
  
  
  
  
  
  
  
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
   
  
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
  
  
  
  
  
  
  
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
  
  
  
  
  
  
   
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
   
   
    
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
   
    
  
  
    
    
  
  
    
    
  
  
    
    
  
  
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Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to 

be signed on its behalf by the undersigned, thereunto duly authorized.  

SIGNATURES  

Dated: June 27, 2012 

   CRYOPORT, INC. 

   By:    / S / R OBERT S TEFANOVICH  
   Robert Stefanovich 
   Chief Financial Officer and 
   Principal Executive Officer 

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the 
Registrant and in the capacities and on the dates indicated:  

Signature  

/ S / S TEPHEN E. W ASSERMAN  
Stephen E. Wasserman 

/ S / R OBERT S. S TEFANOVICH  
Robert S. Stefanovich 

/ S / A DAM M. M ICHELIN  
Adam M. Michelin 

/ S / K AREN M. M ULLER  
Karen M. Muller 

Title  

    Director 

    Chief Financial Officer (Principal Financial and 

    Accounting Officer) and Principal Executive Officer 

    Director 

    Director 

Date  

June 27, 2012 

June 27, 2012 

June 27, 2012 

June 27, 2012 

   
   
   
   
  
  
  
  
  
  
  
  
   
  
  
   
  
  
   
  
  
   
  
  
   
  
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Exhibit No.    

EXHIBIT INDEX  

Description  

3.1 

3.2 

3.3 

3.4 

3.4.1 

3.4.2 

3.4.3 

3.5 

3.6 

3.7 

3.8 

3.9 

3.10 

3.11 

3.12 

3.13 

3.14 

3.15 

Corporate Charter for G.T.5-Limited issued by the State of Nevada on March 15, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Articles of Incorporation for G.T.5-Limited filed with the State of Nevada in May 25, 1990. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Amendment to Articles of Incorporation of G.T.5-Limited increasing the authorized shares of common stock from 5,000,000 
to 100,000,000 shares of common stock filed with the State of Nevada on October 12, 2004. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Amendment to Articles of Incorporation changing the name of the corporation from G.T.5-Limited to CryoPort, Inc. filed 
with the State of Nevada on March 16, 2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-
SB/A4 dated February 23, 2006. 

Amended and Restated Articles of Incorporation dated October 19, 2008. Incorporated by reference to CryoPort’s Current 
Report on Form 8-K filed October 19, 2007. 

Certificate of Amendment to Articles of Incorporation filed with the State of Nevada on November 2, 2009. Incorporated by 
reference to CryoPort’s Amendment No. 1 to Form S-1/A Registration Statement dated January 12, 2010. 

Certificate of Amendment to Amended and Restated Articles of Incorporation filed with the State of Nevada on February 3, 
2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K filed on February 5, 2010. 

Amended and Restated By-Laws of CryoPort, Inc. adopted by the Board of Directors on June 22, 2005 and amended by the 
Certificate of Amendment of Amended and Restated Bylaws of CryoPort, Inc. adopted by the Board of Directors on October 
9, 2009. Incorporated by reference to CryoPort’s Amendment No. 1 to Form S-1/A Registration Statement dated January 12, 
2010. 

Articles of Incorporation of CryoPort Systems, Inc. filed with the State of California on December 11, 2000, including 
Corporate Charter for CryoPort Systems, Inc. issued by the State of California on December 13, 2000. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

By-Laws of CryoPort Systems, Inc. adopted by the Board of Directors on December 11, 2000. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

CryoPort, Inc. Stock Certificate Specimen. Incorporated by reference to CryoPort’s Registration Statement on Form 10-
SB/A4 dated February 23, 2006. 

Code of Conduct for CryoPort, Inc. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 
dated February 23, 2006. 

Code of Ethics for Senior Officers of CryoPort, Inc. and subsidiaries. Incorporated by reference to CryoPort’s Registration 
Statement on Form 10-SB/A4 dated February 23, 2006. 

Statement of Policy on Insider Trading. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 
dated February 23, 2006. 

CryoPort, Inc. Audit Committee Charter, under which the Audit Committee will operate, adopted by the Board of Directors 
on August 19, 2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 
2006. 

CryoPort Systems, Inc. 2002 Stock Incentive Plan adopted by the Board of Directors on October 1, 2002. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Stock Option Agreement ISO—Specimen adopted by the Board of Directors on October 1, 2002. Incorporated by reference 
to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Stock Option Agreement NSO—Specimen adopted by Board of Directors on October 1, 2002. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
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Exhibit No.    

3.16 

3.17 

3.17.1 

3.17.2 

3.17.3 

3.17.4 

3.17.5 

3.17.6 

3.17.7 

4.1 

4.1.1 

4.1.2 

Description  

Warrant Agreement—Specimen adopted by the Board of Directors on October 1, 2002. Incorporated by reference to CryoPort’s 
Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Patents and Trademarks. On File with CryoPort. 

CryoPort Systems, Inc. Patent #6,467,642 information sheet and Assignment to CryoPort Systems, Inc. document. On File with 
CryoPort. 

CryoPort Systems, Inc. Patent #6,119,465 information sheet and Assignment to CryoPort Systems, Inc. document. On File with 
CryoPort. 

CryoPort Systems, Inc. Patent #6,539,726 information sheet and Assignment to CryoPort Systems, Inc. document. On File with 
CryoPort. 

CryoPort Systems, Inc. Trademark #7,583,478,7 information sheet and Assignment to CryoPort Systems, Inc. document. On 
File with CryoPort. 

CryoPort Systems, Inc. Trademark #7,586,797,8 information sheet and Assignment to CryoPort Systems, Inc. document. On 
File with CryoPort. 

CryoPort Systems, Inc. Trademark #7,748,667,3 information sheet and Assignment to CryoPort Systems, Inc. document. On 
File with CryoPort. 

CryoPort Systems, Inc. Trademark #7,737,454,1 information sheet and Assignment to CryoPort Systems, Inc. document. On 
File with CryoPort. 

Form of Debenture—Original Issue Discount 8% Secured Convertible Debenture dated September 28, 2007. Incorporated by 
reference to CryoPort’s Registration Statement on Form SB-2 dated November 9, 2007. 

Amendment to Convertible Debenture dated February 19, 2008. Incorporated by reference to CryoPort’s Current Report on 
Form 8-K dated March 7, 2008 and referred to as Exhibit 10.1.10. 

Amendment to Convertible Debenture dated April 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 
8-K dated April 30, 2008 and referred to as Exhibit 10.1.11. 

4.1.2.1 

Annex to Amendment to Convertible Debenture dated April 30, 2008. Incorporated by reference to CryoPort’s Current Report 
on Form 8-K dated April 30, 2008 and referred to as Exhibit 10.1.11.1. 

4.1.3 

4.1.4 

4.1.5 

4.1.6 

4.1.7 

4.1.8 

Amendment to Convertible Debenture dated August 29, 2008. Incorporated by reference to CryoPort’s Current Report on Form 
8-K dated August 29, 2008. 

Amendment to Convertible Debenture effective January 27, 2009 and dated February 20, 2009. Incorporated by reference to 
CryoPort’s Current Report on Form 8-K dated February 19, 2009. 

Amendment to Debentures and Warrants with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified 
Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated September 1, 2009. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated September 17, 2009. 

Amendment to Debentures and Warrants, Agreement and Waiver with Enable Growth Partners LP, Enable Opportunity 
Partners LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated 
January 12, 2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated January 15, 2010. 

Amendment Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified Strategy Master 
Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated February 1, 2010. Incorporated by reference to 
CryoPort’s Current Report on Form 8-K dated February 3, 2010. 

Amended and Restated Amendment Agreements with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce 
Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated February 19, 2010. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated February 26, 2010. 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
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Exhibit No.    

4.1.9 

4.2 

4.3 

4.4 

4.5 

4.6 

4.7 

4.8 

4.9 

4.10 

4.11 

4.12 

4.13 

4.14 

4.15 

4.16 

4.17 

4.18 

Description  

First Amendment to Amended and Restated Amendment Agreements with Enable Growth Partners LP, Enable Opportunity 
Partners LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. dated 
February 23, 2010. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated February 26, 2010. 

Form of Common Stock Purchase Warrant dated September 28, 2007. Incorporated by reference to CryoPort’s Registration 
Statement on Form SB-2 dated November 9, 2007. 

Original Issue Discount 8% Secured Convertible Debenture dated May 30, 2008. Incorporated by reference to CryoPort’s 
Current Report on Form 8-K dated June 9, 2008. 

Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated June 9, 2008 

Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated June 9, 2008 

Form of Warrant and Warrant Certificate in connection with the February 25, 2010 public offering. Incorporated by reference 
to CryoPort’s Amendment No. 5 to Form S-1/A Registration Statement dated February 9, 2010. 

Form of Securities Purchase Agreement in connection with the August to October 2010 private placement. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Form of First Amendment to Security Purchase Agreement in connection with the August to October 2010 private placement. 
Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Form of Securities Purchase Agreement (Continuation of the Placement) in connection with the August to October 2010 
private placement. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Registration Rights Agreement in connection with the August to October 2010 private placement. Incorporated by reference 
to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Form of Joinder to Registration Rights Agreement in connection with the August to October 2010 private placement. 
Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Form of Securities Purchase Agreement in connection with the February 2011 private placement. Incorporated by reference to 
CryoPort’s Registration Statement on Form S-1 dated April 1, 2011. 

Form of Registration Rights Agreement in connection with the February 2011 private placement. Incorporated by reference to 
CryoPort’s Registration Statement on Form S-1 dated April 1, 2011. 

Form of Warrant in connection with the August to October 2010 private placement. Incorporated by reference to CryoPort’s 
Registration Statement on Form S-1/A dated April 22, 2011. 

Form of Warrant in connection with the February 2011 private placement. Incorporated by reference to CryoPort’s 
Registration Statement on Form S-1/A dated April 22, 2011. 

Form of Securities Purchase Agreement. Incorporated by reference to CryoPort’s Current Report of Form 8-K filed with the 
SEC on February 24, 2012. 

Form of Registration Rights Agreement. Incorporated by reference to CryoPort’s Current Report of Form 8-K filed with the 
SEC on February 24, 2012. 

Form of Warrant. Incorporated by reference to CryoPort’s Current Report of Form 8-K filed with the SEC on February 24, 
2012. 

10.1.1 

Stock Exchange Agreement associated with the merger of G.T.5-Limited and CryoPort Systems, Inc. signed on March 15, 
2005. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
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Exhibit No.    

10.1.2 

10.1.3 

10.1.4 

10.1.5 

10.1.6 

10.1.7 

10.1.8 

10.2 

10.2.1 

10.3 

10.4 

10.4.1 

10.5 

10.6 

10.7 

10.8 

10.9 

10.10 

10.11 

Description  

Commercial Promissory Note between CryoPort, Inc. and D. Petreccia executed on August 26, 2005. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Commercial Promissory Note between CryoPort, Inc. and J. Dell executed on September 1, 2005. Incorporated by reference to 
CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Commercial Promissory Note between CryoPort, Inc. and M. Grossman executed on August 25, 2005. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Commercial Promissory Note between CryoPort, Inc. and P. Mullens executed on September 2, 2005. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Commercial Promissory Note between CryoPort, Inc. and R. Takahashi executed on August 25, 2005. Incorporated by 
reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

Exclusive and Representation Agreement between CryoPort Systems, Inc. and CryoPort Systems, Ltda. executed on August 9, 
2001. Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006 and 
referred to as Exhibit 10.1.8. 

Secured Promissory Note and Loan Agreement between Ventana Group, LLC and CryoPort, Inc. dated May 12, 2006. 
Incorporated by reference to CryoPort’s Registration Statement on Form 10-SB/A4 dated February 23, 2006 and referred to as 
Exhibit 10.1.9. 

Business Alliance Agreement dated April 27, 2007, by CryoPort, Inc. and American Biologistics Company LLC. Incorporated 
by reference to CryoPort’s Current Report on Form 8-K dated April 27, 2007 and referred to as Exhibit 10.3. 

Corrected Business Alliance Agreement dated April 27, 2007, by CryoPort, Inc. and American Biologistics Company LLC. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K/A dated May 2, 2007 and referred to as Exhibit 10.3.1. 

Consultant Agreement dated April 18, 2007 between CryoPort, Inc. and Malone and Associates, LLC. Incorporated by 
reference to CryoPort’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 and referred to as Exhibit 
10.4. 

Lease Agreement dated June 26, 2007 between CryoPort, Inc. and Viking Investors—Barents Sea LLC. Incorporated by 
reference to CryoPort’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 and referred to as Exhibit 
10.5. 

Second Amendment To Lease: Renewal dated August 24, 2009, between CryoPort, Inc. and Viking Inventors-Barents Sea 
LLC. Incorporated by reference to CryoPort’s Amendment No. 1 to Form S-1/A Registration Statement dated January 12, 
2010. 

Securities Purchase Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on 
Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.6. 

Registration Rights Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on 
Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.7. 

Security Agreement dated September 27, 2007. Incorporated by reference to CryoPort’s Registration Statement on Form SB-2 
dated November 9, 2007 and referred to as Exhibit 10.8. 

Sitelet Agreement between FedEx Corporate Services, Inc. and CryoPort Systems, Inc. dated January 23, 2008. Incorporated 
by reference to CryoPort’s Current Report on Form 8-K dated February 1, 2008 and referred to as Exhibit 10.9. 

Securities Purchase Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated June 9, 2008 and referred to as Exhibit 10.10. 

Registration Rights Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K 
dated June 9, 2008 and referred to as Exhibit 10.11. 

Waiver dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated June 9, 2008 and 
referred to as Exhibit 10.12. 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
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Exhibit No.    

Description  

10.12 

10.13 

10.14 

10.15 

10.16 

10.17 

10.18 

10.19 

10.20 

10.21 

10.22 

10.23 

10.24 

10.25 

10.26 

10.27 

10.28 

Security Agreement dated May 30, 2008. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated June 9, 
2008 and referred to as Exhibit 10.13. 

Board of Directors Agreement between Larry G. Stambaugh and CryoPort, Inc. dated December 10, 2008. Incorporated by 
reference to CryoPort’s Current Report on Form 8-K dated December 5, 2008 and referred to as Exhibit 10.15. 

Rental Agreement with FedEx Corporate Services and CryoPort, Inc. dated May 15, 2009 (CryoPort has filed a Confidential 
Treatment Request under Rule 24b-5 of the Exchange Act, for parts of this document). Incorporated by reference to 
CryoPort’s Annual Report on Form 10-K for the year ended March 31, 2009 and referred to as Exhibit 10.16. 

Settlement Agreement and Mutual Release with Dee Kelly and CryoPort, Inc. dated July 24, 2009. Incorporated by reference 
to CryoPort’s Current Report on Form 8-K dated July 20, 2009 and referred to as Exhibit 10.14. 

Consent, Waiver and Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified 
Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and CryoPort Inc. and its subsidiary dated July 30, 2009. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated July 29, 2009 and referred to as Exhibit 10.15. 

Employment Agreement with Larry G. Stambaugh and CryoPort, Inc. dated August 1, 2009. Incorporated by reference to 
CryoPort’s Current Report dated August 21, 2009 and referred to as Exhibit 10.19. 

Letter Accepting Consulting Agreement dated October 1, 2007 with Carpe DM, Inc. and CryoPort, Inc. Incorporated by 
reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated March 25, 2009 and referred to as Exhibit 10.1. 

Master Consulting and Engineering Services Agreement dated October 9, 2007 with KLATU Networks, LLC and CryoPort, 
Inc. Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated March 25, 2009 and referred to 
as Exhibit 10.2. 

Investment Banker Termination Agreement dated April 6, 2009 with Bradley Woods & Co. Ltd., SEPA Capital Corp., 
Edward Fine, and CryoPort, Inc. Incorporated by reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated 
April 13, 2009 and referred to as Exhibit 10.1. 

Attorney-Client Retainer Agreement with Gary Curtis Cannon and CryoPort, Inc. dated December 1, 2007. Incorporated by 
reference to CryoPort, Inc.’s Registration Statement on Form S-8 dated June 11, 2009 and referred to as Exhibit 10.3. 

CryoPort, Inc., 2009 Stock Incentive Plan. Incorporated by reference to CryoPort’s Current Report on Form 8-K dated 
October 9, 2009 and referred to as Exhibit 10.21. 

CryoPort, Inc., Form Incentive Stock Option Award Agreement under the CryoPort, Inc., 2009 Stock Incentive Plan. 
Incorporated by reference to CryoPort’s Current Report on Form 8-K dated October 9, 2009 and referred to as Exhibit 10.22. 

Warrant issued to Rodman & Renshaw, LLC in connection with the February 25, 2010 public offering. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Form of Non-Qualified Stock Option Award Agreement under the CryoPort, Inc. 2009 Stock Incentive Plan. Incorporated by 
reference to CryoPort’s Registration Statement on Form S-8 dated April 27, 2010. 

Underwriting Agreement with Rodman & Renshaw, LLC and CryoPort in connection with the February 25, 2010 public 
offering. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Letter of Engagement with Maxim Group, LLC and CryoPort dated as of June 16, 2010. Incorporated by reference to 
CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Second Amendment to Engagement Agreement with Maxim Group, LLC. Incorporated by reference to CryoPort’s 
Registration Statement on Form S-1 dated October 19, 2010. 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Table of Contents  

Exhibit No.    

Description  

10.29 

10.30 

10.31 

10.32 

10.33 

10.34 

10.35 

10.36 

10.37 

10.38 

10.39 

10.40 

10.41 

10.42 

10.43 

10.44 

21 

23.1 

Selling Agency Agreement for CryoPort, Inc. Stock and Warrants with Emergent Financial Group, Inc. and CryoPort dated as 
of July 27, 2010. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

Addendum to Selling Agency Agreement for CryoPort, Inc. Stock and Warrants with Emergent Financial Group, Inc. and 
CryoPort dated as of August 31, 2010. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated 
October 19, 2010. 

Agreement dated as of January 13, 2010, between CryoPort, Inc. and Federal Express Corporation. Incorporated by reference 
to CryoPort’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2010.** 

First Amendment to Master Consulting and Engineering Services Agreement dated as of April 23, 2009, between CryoPort, 
Inc. and KLATU Networks, LLC. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated October 
19, 2010. 

Second Amendment to Master Consulting and Engineering Services Agreement dated as of November 1, 2010, between 
CryoPort, Inc. and KLATU Networks, LLC. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 
dated October 19, 2010. 

Selling Agency Agreement between CryoPort, Inc. and Emergent Financial Group, Inc. dated as of February 4, 2011. 
Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated April 1, 2011. 

Consent to Appointment of Co-Agent Agreement between CryoPort, Inc. and Emergent Financial Group, Inc. dated as of 
February 10, 2011. Incorporated by reference to CryoPort’s Registration Statement on Form S-1 dated April 1, 2011. 

Letter Agreement between CryoPort, Inc. and Maxim Group LLC dated February 11, 2011. Incorporated by reference to 
CryoPort’s Registration Statement on Form S-1 dated April 1, 2011. 

2011 Stock Incentive Plan. Incorporated by reference to Registrant’s Definitive Proxy Statement with respect to the 2011 
Annual Meeting of Stockholders held on September 22, 2011, as filed with the SEC on August 15, 2011. 

Form of Stock Option Award Agreement. Incorporated by reference to Exhibit 10.37 to Registrant’s Current Report on 
Form 8-K filed with the SEC on September 27, 2011. 

Form of Non-Qualified Stock Option Award Agreement. Incorporated by reference to Exhibit 10.38 to Registrant’s Current 
Report on Form 8-K filed with the SEC on September 27, 2011. 

Engagement Letter dated January 25, 2012 between CryoPort, Inc. and Craig-Hallum Capital Group LLC. Incorporated by 
reference to Exhibit 10.40 to Registrant’s Registration Statement on Form S-1 dated March 23, 2012. 

Amendment to Engagement Letter dated February 13, 2012 between CryoPort, Inc. and Craig-Hallum Capital Group LLC. 
Incorporated by reference to Exhibit 10.41 to Registrant’s Registration Statement on Form S-1 dated March 23, 2012. 

Appointment of Co-Placement Agent dated February 7, 2012 between CryoPort, Inc. and Maxim Group LLC. Incorporated by 
reference to Exhibit 10.42 to Registrant’s Registration Statement on Form S-1 dated March 23, 2012. 

Appointment of Co-Placement Agent dated February 8, 2012 between CryoPort, Inc. and Emergent Financial Group, Inc. 
Incorporated by reference to Exhibit 10.43 to Registrant’s Registration Statement on Form S-1 dated March 23, 2012. 

Amendment to Appointment of Co-Placement Agent dated February 28, 2012 between CryoPort, Inc. and Emergent Financial 
Group, Inc. Incorporated by reference to Exhibit 10.44 to Registrant’s Registration Statement on Form S-1 dated March 23, 
2012. 

Subsidiaries of Registrant* 

Consent of Independent Registered Public Accounting Firm—KMJ Corbin & Company LLP.* 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Table of Contents  

Exhibit No. 

31.1 

32.1 

Rule 13a-14(a)/15d-14(a) Certification of Principal Executive Officer and Chief Financial Officer.* 

Certification Pursuant to U.S.C. §1350 of Principal Executive Officer and Chief Financial Officer.* 

Description  

101.INS***    

XBRL Instance Document.* 

101.SCH***   

XBRL Taxonomy Extension Schema Document.* 

101.CAL***   

XBRL Taxonomy Extension Calculation Linkbase Document.* 

101.DEF***   

XBRL Taxonomy Extension Definition Linkbase Document.* 

101.LAB***   

XBRL Taxonomy Extension Label Linkbase Document.* 

101.PRE***   

XBRL Taxonomy Extension Presentation Linkbase Document.* 

Filed herewith 

* 
**  Portions omitted pursuant to a request for confidential treatment filed separately with the Commission. 
***  Pursuant to applicable securities laws and regulations, we are deemed to have complied with the reporting obligation relating to the 

submission of interactive data files in such exhibits and are not subject to liability under any anti-fraud provisions of the federal securities 
laws as long as we have made a good faith attempt to comply with the submission requirements and promptly amend the interactive data 
files after becoming aware that the interactive data files fail to comply with the submission requirements. Users of this data are advised 
that, pursuant to Rule 406T, these interactive data files are deemed not filed and otherwise are not subject to liability. 

  
  
  
  
CryoPort Systems, Inc.  

CRYOPORT, INC.  
Subsidiaries of Registrant  

EXHIBIT 21 

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

We consent to the incorporation by reference in the Registration Statement No. 333-166327 on Form S-8 of our report dated June 15, 2012 
(which includes an explanatory paragraph regarding Cryoport, Inc.’s ability to continue as a going concern), with respect to the consolidated 
financial statements of Cryoport, Inc. included in this Annual Report on Form 10-K of Cryoport, Inc. for the years ended March 31, 2012 and 
2011.  

Exhibit 23.1 

/s/ KMJ Corbin & Company LLP  

Costa Mesa, California  
June 27, 2012  

Certification of Principal Executive Officer and Chief Financial Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

EXHIBIT 31.1 

I, Robert Stefanovich, certify that:  

1. I have reviewed this annual report on Form 10-K of CryoPort, Inc.;  

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make 
the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by 
this report;  

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects 
the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;  

4. I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15
(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:  

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under my 

supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to me by others 
within those entities, particularly during the period in which this report is being prepared;  

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under my 

supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for 
external purposes in accordance with generally accepted accounting principles;  

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report my conclusions about the 

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and  

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most 

recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to 
materially affect, the registrant’s internal control over financial reporting; and  

5. I have disclosed, based on my most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit 
committee of the registrant’s board of directors (or persons performing the equivalent functions):  

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are 

reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and  

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal 

control over financial reporting.  

Dated: June 27, 2012 

   Signed:    /s/ ROBERT STEFANOVICH 
   Robert Stefanovich 
   Principal Executive Officer and Chief Financial Officer 

   
  
  
  
  
  
Certification Pursuant to U.S.C. §1350 of Principal Executive Officer  
and Chief Financial Officer  

EXHIBIT 32.1 

I, Robert Stefanovich, Principal Executive Officer and Chief Financial Officer of CryoPort, Inc. (the “Company”), certify, pursuant to Rule 

13(a)-14(b) or Rule 15(d)-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2012 (the “Report”) fully complies with the 
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the 
Company.  

Dated: June 27, 2012  

/s/ Robert Stefanovich 
Robert Stefanovich, Principal Executive Officer and 
Chief Financial Officer 

A signed original of this written statement required by Section 906 has been provided to CryoPort, Inc. and will be retained by CryoPort, 

Inc. and furnished to the Securities and Exchange Commission or its staff upon request.  

This Certification is being furnished pursuant to Rule 15(d) and shall not be deemed “filed” for purposes of Section 18 of the Exchange 
Act (15 U.S.C. 78r), or otherwise subject to the liability of that section. This Certification shall not be deemed incorporated by reference into any 
filing under the Securities Act or the Exchange Act, except to the extent that the Company specifically incorporates it by reference.