Quarterlytics / Industrials / Integrated Freight & Logistics / Cryoport, Inc.

Cryoport, Inc.

cyrx · NASDAQ Industrials
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Ticker cyrx
Exchange NASDAQ
Sector Industrials
Industry Integrated Freight & Logistics
Employees 1090
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FY2013 Annual Report · Cryoport, Inc.
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UNITED STATES  
SECURITIES AND EXCHANGE COMMISSION  
Washington, D.C. 20549  

  FORM 10-K  

(Mark One)  
  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 

For the fiscal year ended March 31, 2013  

(cid:1)  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 

OR  

For the transition period from                 to                   

Commission file number: 001-34632  

CRYOPORT, INC.  

(Exact name of Registrant as specified in its charter)  

Nevada 
(State or other jurisdiction of  
incorporation or organization)  

20382 Barents Sea Circle,  
Lake Forest, California  
(Address of principal executive offices) 

88-0313393 
(I.R.S. Employer  
Identification No.)  

92630  
(Zip Code) 

(949) 470-2300  
(Registrant’s telephone number, including area code)  

Securities registered pursuant to Section 12(b) of the Act:    

Title of Each Class 
Common Stock, $0.001 par value 

Name of Each Exchange on Which Registered 
OTC Market 

Securities registered pursuant to Section 12(g) of the Act:  
Common Stock, $0.001  
Warrants to Purchase Common Stock  

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes   (cid:1)     No     

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.    Yes   (cid:1)     No     

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act 
of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject 
to such filing requirements for the past 90 days.    Yes        No   (cid:1)  

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data 
File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or 
for such shorter period that the registrant was required to submit and post such files).    Yes        No   (cid:1)  

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405) is not contained herein, and will not 
be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this 
Form 10-K or any amendment to this Form 10-K.     

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting 
company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. 
(check one):  

Large accelerated filer 

Non-accelerated filer 

(cid:1) 

(cid:1) 

Accelerated filer 

Smaller reporting company 

(cid:1) 

 

   
   
   
    
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
   
  
  
  
  
  
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).    Yes   (cid:1)     No     

The aggregate market value of Common Stock held by non-affiliates as of September 30, 2012 was $7,151,190 (1)  

Number of shares of Common Stock outstanding as of June 17, 2013: 38,260,628  

DOCUMENTS INCORPORATED BY REFERENCE  

Part III of this report incorporates certain information by reference from the registrant’s proxy statement for the annual meeting of stockholders, 
which proxy statement will be filed no later than 120 days after the close of the registrant’s fiscal year ended March 31, 2013.  

(1)  Excludes 2,004,677 shares of common stock held by directors and officers, and any stockholder whose ownership exceeds five percent of 

the shares outstanding as of September 30, 2012. 

   
   
   
   
   
   
   
    
  
  
  
CRYOPORT, INC.  

Fiscal Year 2013 10-K Annual Report  

Table of Contents  

PART I 

Item 1 Business 
Item 1A Risk Factors 
Item 1B Unresolved Staff Comments 
Item 2 Properties 
Item 3 Legal Proceedings 
Item 4 Mine Safety Disclosures 

PART II 

Item 5 Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities 
Item 6 Selected Financial Data 
Item 7 Management’s Discussion and Analysis of Financial Condition and Results of Operations 
Item 7A Quantitative and Qualitative Disclosures About Market Risk 
Item 8 Financial Statements and Supplementary Data 
Item 9 Changes in and Disagreements with Accountants on Accounting and Financial Disclosures 
Item 9A Controls and Procedures 
Item 9B Other Information 

Item 10 Directors, Executive Officers and Corporate Governance 
Item 11 Executive Compensation 
Item 12 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters 
Item 13 Certain Relationships and Related Transactions, and Director Independence 
Item 14 Principal Accountant Fees and Services 

PART III 

Item 15 Exhibits and Consolidated Financial Statement Schedules 
Signatures 

PART IV 

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PART I  

In this Annual Report, the terms “we”, “us”, “our”, “Company” and “Cryoport” refer to Cryoport, Inc., and our wholly owned subsidiary, 
Cryoport Systems, Inc. This Annual Report contains forward-looking statements that involve risks and uncertainties. The inclusion of forward-
looking statements should not be regarded as a representation by us or any other person that the objectives or plans will be achieved because our 
actual results may differ materially from any forward-looking statement. The words “may,” “should,” “plans,” “believe,” “anticipate,” 
“estimate,” “expect,” their opposites and similar expressions are intended to identify forward-looking statements, but the absence of these words 
does not necessarily mean that a statement is not forward-looking. We caution readers that such statements are not guarantees of future 
performance or events and are subject to a number of factors that may tend to influence the accuracy of the statements, including but not limited 
to, those risk factors outlined in the section titled “Risk Factors” as well as those discussed elsewhere in this Annual Report. You should not 
unduly rely on these forward-looking statements, which speak only as of the date of this Annual Report. We undertake no obligation to publicly 
revise any forward-looking statement to reflect circumstances or events after the date of this Annual Report or to reflect the occurrence of 
unanticipated events. You should, however, review the factors and risks we describe in the reports that we file from time to time with the 
Securities and Exchange Commission (“SEC”) after the date of this Annual Report.  

In addition, we own or have rights to the registered trademark Cryoport ® (both alone and with a design logo) and Cryoport Express ® (both 
alone and with a design logo). All other Company names, registered trademarks, trademarks and service marks included in this Annual Report 
are trademarks, registered trademarks, service marks or trade names of their respective owners.  

Item 1. 

BUSINESS 

Overview  

We provide leading edge frozen shipping logistics solutions to the biotechnology and life science industries. Since 2011, through the 
completion of the combination of purpose-built proprietary hardware, software information technologies and developed logistics knowhow 
known as “total turnkey management” we have provided logistics management for frozen shipping to these industries. Our solutions are 
disruptive to “old technologies” and provide reliable, economic alternatives to existing products and services utilized for frozen shipping in 
biotechnology and life sciences including stem cells, cell lines, vaccines, diagnostic materials, semen and embryos for in-vitro fertilization, cord 
blood, bio-pharmaceuticals, infectious substances and other items that require continuous exposure to frozen or cryogenic temperatures. Our 
solutions contribute to the reliability, efficiency, and effectiveness of clinical trials.  

Cryoport Express ® Solutions include a cloud-based logistics management software branded as the Cryoportal TM . The Cryoportal 

supports the management of the entire shipment process through a single interface which includes initial order input, document preparation, 
customs clearance, courier management, shipment tracking, issue resolution, and delivery. Cryoport’s total turnkey logistics solutions offer 
reliability, cost effectiveness, and convenience, while the use of recyclable and reusable components provides “green”, environmentally friendly 
solutions. The Cryoportal provides an array of unique information dashboards and validation documentation for every shipment.  

Integral to our logistics solutions are the Cryoport Liquid Nitrogen Dry Vapor Shippers (Cryoport Express ® Shippers), which are cost-

effective and reusable cryogenic transport containers (patented vacuum flasks) utilizing innovative liquid nitrogen (LN2) “dry vapor” 
technology. Cryoport Express ® Shippers are non-hazardous, IATA (International Air Transport Association) certified, and validated to maintain 
stable temperatures below minus 150° Celsius for a 10-plus day dynamic shipment period. The Company currently features two Cryoport 
Express ® Shipper models, the Standard Dry Shipper (holding up to approximately 75-2.0 ml vials) and the High Volume Dry Shipper (holding 
up to approximately 500-2.0 ml vials).  

The Cryoport Express ® Solutions include recording and retaining a fully documented “chain-of-custody” and, at the client’s option, 
“chain-of-condition” for every shipment, helping ensure that quality, safety, efficacy, and stability of shipped commodities are maintained. This 
recorded and archived information allows our customers to meet the exacting requirements necessary for scientific work and for regulatory 
purposes. Cryoport Express ® Solutions can be used by customers, as a “turnkey” solution, through direct access to the cloud-based Cryoportal, 
or by contacting Cryoport Client Care for order entry tasks. Cryoport provides 24/7/365 logistics services through its Client Care team and also 
provides complete training and process management services to support each client’s specific requirements.  

From 2011 through 2012, the Cryoport Express ® Solution was the Company’s principal focus for development and commercialization. 
During the last month’s of 2012, the Company’s approach to the market was enhanced to include a comprehensive solutions orientation and it 
expanded its service offering to address the various broader market needs in the biotechnology and life science industries. Today, as a solutions 
provider, Cryoport tailors its frozen logistics solutions to client requirements. In addition to custom solutions, the Company’s primary customer 
facing solutions offerings are as follows:  

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•  Cryoport Express ® Solution 

The fully outsourced turnkey logistics solution described above.  

•  Customer-Staged Solution 

Cryoport ships an inventory of Cryoport Express ® Shippers to the customer (uncharged and in bulk) enabling the customer to 
charge the shippers at their facility, process their orders through the Cryoportal which permits Cryoport Client Care to oversee 
the logistics of each shipment and the return of the shippers to Cryoport for cleaning, testing and refurbishing. Cryoport Client 
Care provides the 24/7/365 logistics services utilizing its Cryoportal logistics platform.  

•  Customer-Managed Solution 

Cryoport ships a fully charged Cryoport Express ® Shipper(s) to the customer enabling the customer to utilize its internal 
expertise to manage all or a portion of the logistics services. As with the above solutions, the shippers are returned to Cryoport 
for cleaning, testing and refurbishing within a pre-determined time period.  

•  Customer Integrated Logistics 

The Cryoport logistics team provides a tailored and full range of logistics support solutions. In addition to tailoring a 
management solution, the robust, enterprise grade Cryoportal is used to provide complete logistics services while enabling the 
customer to utilize their own packaging solutions or Cryoport Express ® Shippers. Cryoport can provide onsite logistics 
personnel allowing the customer to fully outsource their cold chain logistics needs to Cryoport and focus on its core 
competencies.  

•  Distribution Partnerships 

“Powered by Cryoport” is an important partnership arrangements with integrators, freight forwarders and other logistics 
providers, enabling partners to expand their solutions offering by adding the total Cryoport Express ® Shipper solution to their 
customer offering.  

One of our distribution partners is Federal Express Corporation (“FedEx”). We have an agreement with FedEx to provide frozen shipping 
logistics services through the combination of our purpose-built proprietary technologies and turnkey management processes. FedEx markets and 
sells Cryoport’s services for frozen temperature-controlled cold chain transportation as its FedEx ® Deep Frozen Shipping Solution, on a non-
exclusive basis and at its sole expense. During fiscal year 2013, the Company worked closely with FedEx to further align its sales efforts and 
accelerate penetration within FedEx’s biotechnology and life sciences customer base through improved processes, sales incentives, joint 
customer calls and more frequent communication at the sales and executive level. In addition, the Company has developed a FedEx branded 
portal, which is “powered by the Cryoport”, for use by FedEx and its customers giving them access to the full capabilities of our logistics 
management platform.  

In January 2013, we entered into a master agreement (“FedEx Agreement”) with FedEx renewing these services and providing FedEx with 

a non-exclusive license and right to use a customized version of our Cryoportal for the management of shipments made by FedEx customers. 
The FedEx Agreement became effective on January 1, 2013 and, unless sooner terminated as provided in the FedEx Agreement, expires on 
December 31, 2015.  

Pursuant to an agreement with DHL Express (USA), Inc. (“DHL”), DHL biotechnology and life science customers have direct access to 

our cloud-based order entry and tracking portal to order Cryoport Express ® Dry Shippers and receive preferred DHL shipping rates. The 
agreement covers DHL shipping discounts that may be used to support our customers using the Cryoport Express ® Solutions. In connection with 
the agreement, we have integrated our proprietary Cryoportal to DHL’s tracking and billing systems to provide DHL biotechnology and life 
science customers with a seamless way (“powered by Cryoport”) of shipping their critical biological material worldwide.  

In December 2012, we signed an agreement with Pfizer Inc. relating to Zoetis Inc. (formerly the animal health business unit of Pfizer Inc.) 

pursuant to which we were engaged to manage frozen shipments of a key poultry vaccine. Under this arrangement, the Company is providing 
on-site logistics personnel and its logistics management platform, the Cryoportal TM , to manage shipments from the Zoetis manufacturing site in 
the United States to domestic customers as well as various international distribution centers. As part of its logistics management services, the 
Company will analyze shipping data and processes to further streamline Zoetis’ logistics, ensuring products arrive at their destinations in 
specified conditions, on-time and with the optimum uses of resources. The Company manages Zoetis’ total fleet of dewar flask shippers used for 
this purpose, including liquid nitrogen shippers.  

We offer our solutions to companies in the biotechnology and life sciences industries and specific verticals including manufacturers of 
stem cells and cell lines, diagnostic laboratories, bio-pharmaceuticals, contract research organizations, in-vitro fertilization, cord blood, vaccines, 
tissue, animal husbandry, and other producers of commodities requiring reliable frozen solutions for logistics problems. These companies 
operate within heavily regulated environments and as such, changing vendors and distribution practices typically require a number of steps, 
which may include the audit of our facilities, review of our procedures, qualifying us as a vendor, and performing test shipments. This process 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
can take up to nine months or longer to complete prior to a potential customer adopting one or more of the Cryoport Express ® Solutions.  

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Corporate History and Structure  

We are a Nevada corporation originally incorporated under the name G.T.5-Limited (“GT5”) on May 25, 1990. In connection with a 

Share Exchange Agreement, on March 15, 2005 we changed our name to Cryoport, Inc. and acquired all of the issued and outstanding shares of 
common stock of Cryoport Systems, Inc., a California corporation, in exchange for 2,410,811 shares of our common stock (which represented 
approximately 81% of the total issued and outstanding shares of common stock following the close of the transaction). Cryoport Systems, Inc., 
which was originally formed in 1999 as a California limited liability company, and subsequently reorganized into a California corporation on 
December 11, 2000, remains the operating company under Cryoport, Inc. Our principal executive offices are located at 20382 Barents Sea 
Circle, Lake Forest, CA 92630. The telephone number of our principal executive offices is (949) 470-2300, and our main corporate website is 
www.Cryoport.com. The information on, or that can be accessed through our website is not part of this Annual Report.  

The company became public by a reverse merger with a “shell” company in May 2005. Over time the Company has transitioned from 

being a development company to a fully operational public company, providing cold chain logistics solutions to the biotechnology and life 
sciences industries, globally.  

Since fiscal year 2011 the Company has taken significant steps towards commercialization of the Cryoport Express™ logistics solutions in 

validating, perfecting and expanding its features. The Company has now managed shipments of its Cryoport Express Shippers through its 
Cryoportal into and out of approximately 58 countries, handling a vast array of different biological products and specimens.  

During fiscal year 2012, the Company completed the external validation of its Cryoport Express Standard Shipper to ISTA 7E standards 

and introduced the Cryoport Express High Volume Shipper in response to customer demand. The Company also set up its European distribution 
depot in Holland to better serve its customer base and support sales efforts in Europe.  

During fiscal year 2013, the Company elected Jerrell Shelton President and CEO, realigned its sales team and introduced a solutions sales 
and operating strategy. In addition, and as part of its global expansion plans, the Company set up its Asian distribution depot in Singapore. The 
Company also formed a Commercial Advisory Board (CAB) with Bill Taaffe, a founding member of ICON Clinical Research becoming its first 
member.  

In April 2013, Richard G. Rathmann was appointed to the Company’s Board of Directors.  As a venture fund manager, investor and 

advisor to life science companies over the past 20 years, Rathmann brings new experience and insights to the Board.  

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Cryoport Express ® Solutions  

Cryoport Express ® Solutions consist of the Cryoportal, a cloud-based logistics management software which programmatically assists in 
the management of all aspects of the logistics operations including the Cryoport Express ® Shippers and the Cryoport Express ® Smart Pak data 
logger. The Cryoportal is capable of producing Cryoport Express ® Analytics which reports shipment performance metrics and evaluates 
temperature-monitoring data collected by the data logger during shipment. Cryoport Express ® Solutions are focused on improving the reliability 
of frozen shipping while reducing our clients’ overall operating costs. This is accomplished by providing a complete end-to-end solution for the 
transport and monitoring of frozen or cryogenically preserved biological or pharmaceutical materials shipped primarily though integrators and 
specialty couriers. Certain of the intellectual property underlying our Cryoport Express ® Solutions (other than that related to the Cryoport 
Express ® Shippers) has been, and continues to be, developed under a contract with an outside software development company, with the 
underlying technology licensed to us for exclusive use in our field of use.  

Cryoportal  

The Cryoportal is used by Cryoport, our customers and our business partners to automate the entry of orders, prepare customs 
documentation and to facilitate status and location monitoring of shipped orders while in transit. It is used by Cryoport to assist in managing 
logistics operations and to reduce administrative costs typically provisioned through manual labor relating to order-entry, order processing, 
preparation of shipping documents and back-office accounting. It is also used to support the high level of customer service expected by the 
industry. Certain features of the Cryoportal reduce operating costs and facilitate the scaling of Cryoport’s business, but more importantly they 
offer significant value to the customer in terms of cost avoidance and risk mitigation. Examples of these features include automation of order 
entry, development of Key Performance Indicators (“KPI”) to support our efforts for continuous process improvements in our business, and 
programmatic exception monitoring to detect and sometimes anticipate delays in the shipping process, often before the customer or the shipping 
company becomes aware of them.  

The Cryoportal also serves as the communications center for the management, collection and analysis of Smart Pak data collected from 

Smart Pak data loggers in the field. Data is converted into pre-designed reports containing valuable and often actionable information that 
becomes the quality control standard or “pedigree” of the shipment. This information can be utilized by Cryoport to provide valuable feedback to 
the customer relating to their shipments.  

The Cryoportal was developed as a carrier-agnostic system, allowing the customer and the Cryoport Client Care team the use of multiple 

integrators, freight forwarders or couriers depending on the specific requirements and customer preferences. To increase operational efficiencies 
the Cryoportal has already been integrated with the tracking systems of two major integrators and is planning to integrate with other key logistics 
providers.  

The Cryportal was developed for time- and temperature-sensitive shipments that are required to maintain specific temperatures, such as 

ambient (between 20 and 25°C), chilled (between 2 and 8°C) or frozen (minus 10°C or less all the way down to cryogenic temperatures) to 
ensure that the shipped specimen is not subject to degradation or out of its designated “safe” range. While our current focus is on frozen 
shipments within the biotechnology and life sciences industries using the logistics solutions described herein, the use of the Cryoportal can and 
may be extended into other temperature ranges.  

The Cryoport Express ® Shippers  

Our Cryoport Express ® Shippers are cryogenic dry vapor shippers capable of maintaining cryogenic temperatures of minus 150° Celsius 

or below for a dynamic shipping period of 10 or more days. A dry cryogenic shipper is a device that uses liquid nitrogen contained inside a 
vacuum insulated bottle which serves as a refrigerant to provide stable storage temperatures below minus 150° Celsius. Our Cryoport Express ® 
Shippers are designed to ensure that there is no pressure build up as the liquid nitrogen evaporates or spillage of liquid nitrogen. We have 
developed a proprietary retention system to ensure that liquid nitrogen stays inside the vacuum container, which allows the shipper to be 
designated as a dry shipper meeting International Air Transport Association (“IATA”) requirements. Biological or pharmaceutical specimens are 
stored in a specimen chamber, referred to as a “well” inside the container, refrigeration is provided by cold nitrogen gas evolving from the liquid 
nitrogen entrapped within the retention system. Specimens that may be transported using our cryogenic shipper include live cell scientific or 
pharmaceutical commodities such as cancer vaccines, diagnostic materials, semen, eggs and embryos, infectious substances and other items that 
require continuous exposure to frozen or cryogenic temperatures (e.g., temperatures below minus 150° Celsius).  

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We currently offer two sizes of dry vapor shippers, the Cryoport Express ® Standard Shipper with a storage capacity of up to 75 0.2ml 

vials and the Cryoport Express ® High Volume Shipper which was introduced in January of 2012 with a capacity of up to 500 0.2ml vials.  

The technology underlying the Cryoport Express ® Shipper was developed by modifying and advancing technology from our first 
generation of reusable cryogenic dry shippers. While our Cryoport Express ® Shippers share many of the characteristics and basic design details 
of our earlier shippers, we are manufacturing our Cryoport Express ® Shippers from alternative, lower cost and lower weight materials, which 
reduces overall operating costs. We maintain ongoing development efforts related to our shippers which are principally focused on material 
properties, particularly those properties related to the low temperature requirement, the vacuum retention characteristics, such as the permeability 
of the materials, and lower cost and lower weight materials in an effort to meet the market needs for achieving a lower cost frozen and cryogenic 
shipping solution. Other advances additional to the development work on the cryogenic container include both an improved liquid nitrogen 
retention system and a secondary protective, spill proof packaging system. This secondary packaging system, contains a low cost outer 
packaging that lends itself to disposability, and it is made of recyclable materials. Further, it adds an additional liquid nitrogen retention 
capability to further assure compliance with IATA and ICAO regulations that prohibit egress of liquid nitrogen from the shipping package. 
ICAO stands for the International Civil Aviation Organization, which is a United Nations organization that develops regulations for the safe 
transport of dangerous goods by air.  

Cryoport Express ® Standard Shippers  

The Cryoport Express ® Standard Shippers are lightweight, low-cost, re-usable dry vapor liquid nitrogen storage containers that we believe 

combine the best features of packaging, cryogenics and high vacuum technology. A Cryoport Express ® Standard Shipper is composed of an 
aluminum metallic dewar flask, with a well for holding the biological material in the inner chamber. The dewar flask, or “thermos bottle,” is an 
example of a practical device in which the conduction, convection and radiation of heat are reduced as much as possible. The inner chamber of 
the shipper is surrounded by a high surface, low-density material which retains the liquid nitrogen in-situ by absorption, adsorption and surface 
tension. Absorption is defined as the taking up of matter in bulk by other matter, as in the dissolving of a gas by a liquid, whereas adsorption is 
the surface retention of solid, liquid or gas molecules, atoms or ions by a solid or liquid. This material absorbs liquid nitrogen several times 
faster than currently used materials, while providing the shipper with a hold time and capacity to transport biological materials safely and 
conveniently. The annular space between the inner and outer dewar chambers is evacuated to a very high vacuum (10-6 Torr). The specimen-
holding chamber has a primary cap to enclose the specimens, and a removable and replaceable secondary cap to further enclose the specimen-
holding container and to contain the liquid nitrogen. The entire dewar vessel is then wrapped in a plurality of insulating and cushioning materials 
and placed in a disposable outer packaging made of recyclable material. The Cryoport Express ® Standard Shipper has a storage capacity of up to 
75 0.2ml vials.  

Cryoport Express ® High Volume Shippers  

The Cryoport Express ® High Volume Shipper also uses a dry vapor liquid nitrogen (LN2) technology to maintain below -150° C 
temperatures with a dynamic shipping endurance of 10 days. The Cryoport Express ® High Volume Shipper is based on the same dry vapor 
technology as Cryoport’s original standard dry shipper and utilizes an absorbent material to hold LN2, thus providing the extended endurance 
time and IATA validation as a non-hazardous shipping container. The high volume dry shipper is reusable and recyclable, making it a highly 
sustainable and cost effective method of transporting life science materials. The Cryoport Express ® High Volume Shipper has a storage capacity 
of up to 500 0.2ml vials.  

We believe Cryoport Express ® Solutions are the best and most cost effective solution available in the biotechnology and life sciences 
markets and satisfy customer needs and scientific and regulatory requirements relating to the shipment of time- and temperature-critical, frozen 
and refrigerated transport of biological materials, such as stem cells, cell lines, pharmaceutical clinical trial samples, gene biotechnology, 
infectious materials handling, animal and human reproduction markets. Due to our proprietary technology and innovative design, our shippers 
are less prone to losing functional hold time when not kept in an upright position than the competing products because our proprietary dry vapor 
technology and innovative design prevent the spilling or leakage of the liquid nitrogen when the container is tipped or on its side which would 
otherwise adversely affect the functional hold time of the shipper.  

An important feature of our Cryoport Express ® Shippers is their compliance with the stringent packaging requirements of IATA Packing 
Instructions 602 and 650, respectively. These specifications include meeting internal pressure (hydraulic) and drop performance requirements.  

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The Cryoport Express ® Smart Pak  

Temperature monitoring is a high value feature from our customers’ perspective as it is an effective and reliable method to determine that 

the shipment materials were not damaged or did not experience degradation during shipment due to temperature fluctuations. Our Smart Pak 
System is a self-contained automated data logger capable of recording cryogenic temperatures of samples shipped in our Cryoport Express® 
Shippers. The data-logging temperature probe is in the vapor plug of the shipper for the most accurate reading. The temperature mapping 
includes both the temperature inside the chamber (which is closest to the actual biomaterial) and the external temperature. This reading, 
combined with the mapping of every shipment check-in point, provides a holistic view of the complete shipping process. At the client’s election, 
shipments can have a full chain-of-custody and chain-of-condition with both data monitoring and analysis available.  

Chain-of-Condition  

Data monitoring starts with a custom built data logger. The data logger can be set up to report during the shipment and/or after the 
shipment. For those shipments involving biologics, clinical trials or any other material that needs to be verified before receiving, the information 
recorded by the data logger can be downloaded to the data station onsite. Alternatively, Cryoport can upload the temperature data from the data 
logger for analysis to the Cryoportal upon return of the shipper. The Cryoportal also acts as the data repository for all shipment and temperature 
information, which the customer can access remotely through the internet. Chain of condition service is available at the client’s election.  

Chain-of-Custody  

When overlaid with the carrier check-ins, the data monitor and analysis also provides a chain of custody. The report from the data monitor 

serves as analysis for temperature monitoring of the entire shipment as well as a tampering warning. If the client has elected to have chain of 
condition monitoring, each time the container is opened there is a temperature record. The report will identify outlier temperature excursions 
such as opening the shipment in customs or tampering and allow for more conclusive investigations to ensure specimen shipped were not 
adversely impacted during shipment.  

Cryoport Express ® Analytics  

The Cryoportal is an important information technology element of our business strategy and has been designed to support planned future 
features to allow for an expansion of our solutions offering. Analytics is a term used by IT professionals to refer to performance benchmarks or 
Key Performance Indicators (KPI’s) that management utilizes to measure performance against desired standards. Examples for analytics tracked 
through the Cryoportal include time-based metrics for order processing time and on-time deliveries by our shipping partners, as well as profiling 
shipping lanes to determine average transit times and predicting potential shipping exceptions based on historical metrics. The analytical results 
are being utilized by Cryoport to render consultative and proactive customer services.  

Biological Material Holders  

A patented containment bag is used in connection with the shipment of infectious or dangerous goods using the Cryoport Express® 
Shippers. Up to 75 cryovials (polypropylene vials with high-density polyethylene closures), set on aluminum canes are placed into an absorbent 
pouch, which is designed to absorb the entire contents of all the vials in the event of leakage. This pouch is then placed in a watertight Tyvek bag 
(secondary packaging) capable of withstanding cryogenic temperatures, and then sealed. This bag is then placed into the well of the cryogenic 
shipper.  

Other Product Candidates and Development Activities  

We are continuing our research and development efforts to further refine our current technology as well as explore opportunities with 

partners to offer complementary packaging solutions for frozen temperature (- 10° Celsius or less), chilled temperature (2° to 8° Celsius) and 
ambient temperature (between 20° and 25° Celsius) shipping markets.  

We also continue to further expand the functionality of our Cryoportal, to ensure a high level of effectiveness and efficiency in the cold 

chain logistics process and to allow for intelligent and easy data monitoring and analysis.  

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Government Regulation  

The shipping of diagnostic specimens, infectious substances and dangerous goods, whether via air or ground, falls under the jurisdiction of 

many state, federal and international agencies. The quality of the containers, packaging materials and insulation that protect a specimen 
determine whether or not it will arrive in a usable condition. Many of the regulations for transporting dangerous goods in the United States are 
determined by international rules formulated under the auspices of the United Nations. For example, the ICAO is the United Nations 
organization that develops regulations (Technical Instructions) for the safe transport of dangerous goods by air. If shipment is by air, compliance 
with the rules established by IATA is required. IATA is a trade association made up of airlines and air cargo couriers that publishes annual 
editions of the IATA Dangerous Goods Regulations. These regulations interpret and add to the ICAO Technical Instructions to reflect industry 
practices. Additionally, the CDC has regulations (published in the Code of Federal Regulations) for interstate shipping of specimens, and OSHA 
also addresses the safe handling of Class 6.2 Substances. Our Cryoport Express ® Shippers meet Packing Instructions 602 and 650 and are 
certified for the shipment of Class 6.2 Dangerous Goods per the requirements of the ICAO Technical Instructions for the Safe Transport of 
Dangerous Goods by Air and IATA. Our present and planned future versions of the Cryoport Smart Pak data logger will likely be subject to 
regulation by Federal Aviation Administration (“FAA”), Federal Communications Commission (“FCC”), Food and Drug Administration 
(“FDA”), International Air Association (“IATA”) and possibly other agencies which may be difficult to determine on a global basis.  

We are also subject to numerous other federal, state and local laws relating to such matters as safe working conditions, manufacturing 
practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. We may incur significant 
costs to comply with such laws and regulations now or in the future.  

Manufacturing and Raw Materials  

Manufacturing . Due to our adequate levels of dewar inventories for the coming year, manufacturing is currently suspended. The 
component parts for our shippers are primarily manufactured at third party manufacturing facilities. We also have a warehouse at our facility in 
Lake Forest, California, where we are capable of manufacturing certain parts and to fully assemble our shipppers. Most of the components that 
we use in the manufacture of our shippers are available from more than one qualified supplier. For some components, however, there are 
relatively few alternate sources of supply and the establishment of additional or replacement suppliers may not be accomplished immediately, 
however, we have identified alternate qualified suppliers. Should this occur, we believe that with our current level of inventory of shippers we 
have enough inventory to cover our forecasted demand. There are no specific agreements with any manufacturer nor are there any long term 
commitments to any manufacturer. We believe that most of the manufacturers currently used by us could be replaced within a short period of 
time as none have a proprietary component or a substantial capital investment specific to our shippers.  

Our production and manufacturing process incorporates innovative technologies developed for aerospace and other industries which are 

cost effective, easier to use and more functional than the traditional dry ice devices and other methods currently used for the shipment of 
temperature-sensitive materials. Our manufacturing process uses non-hazardous cleaning solutions, which are provided and disposed of by a 
supplier approved by the Environmental Protection Agency (the “EPA”). EPA compliance costs for us are therefore negligible.  

Cryoport Express ® High Volume Shippers are purchased from a third party and modified using our proprietary technology and know-

how.  

Raw Materials . Various common raw materials are used in the manufacture of our shippers and in the development of our technologies. 

These raw materials are generally available from several alternate distributors and manufactures. We have not experienced any significant 
difficulty in obtaining these raw materials and we do not consider raw material availability to be a significant factor in our business.  

Patents and Proprietary Rights  

In order to remain competitive, we must develop and maintain protection on the proprietary aspects of our technologies. We rely on a 

combination of patents, copyrights, trademarks, trade secret laws and confidentiality agreements to protect our intellectual property rights. We 
currently own three registered United States trademarks and three issued United States patents primarily covering various aspects of our 
products. In addition, we have filed a patent application for various aspects of our shipper and web-portal, which includes, in part, various 
aspects of our business model referred to as the Cryoport Express ® System, and we intend to file additional patent applications to strengthen our 
intellectual property rights. The technology covered by the above indicated issued patents relates to matters specific to the use of liquid nitrogen 
shippers in connection with the shipment of biological materials. The concepts include those of disposability, package configuration details, 
liquid nitrogen retention systems, systems related to thermal performance, systems related to packaging integrity, and matters generally relevant 
to the containment of liquid nitrogen. Similarly, the trademarks mentioned relate to the cryogenic temperature shipping activity. Issued patents 
and trademarks currently owned by us include:  

Type: 
Patent 
Patent 
Patent 
Trademark 
Trademark 
Trademark 

Issued 

   Expiration    
No. 
6,467,642      Oct. 22, 2002   Oct. 21, 2022   
6,119,465      Sep. 19, 2000   Sep. 18, 2020   
6,539,726      Apr. 1, 2003    Mar 31, 2023   
N/A   
N/A   
N/A   

     7,583,478,7      Oct. 8, 2002   
     7,748,667,3      Feb. 3, 2009   
     7,737,454,1     Mar. 17, 2009   

   
   
   
   
   
   
   
   
     
   
   
  
  
    
    
    
    
7 

   
Our success depends in part upon our ability to develop proprietary products and technologies and to obtain patent coverage for these 

products and technologies. We intend to file trademark and patent applications covering any newly developed products, methods and 
technologies. However, there can be no guarantee that any of our pending or future filed applications will be issued as patents. There can be no 
guarantee that the U.S. Patent and Trademark Office or some third party will not initiate an interference proceeding involving any of our pending 
applications or issued patents. Finally, there can be no guarantee that our issued patents or future issued patents, if any, will provide adequate 
protection from competition.  

Patents provide some degree of protection for our proprietary technology. However, the pursuit and assertion of patent rights involve 
complex legal and factual determinations and, therefore, are characterized by significant uncertainty. In addition, the laws governing patent 
issuance and the scope of patent coverage continue to evolve. Moreover, the patent rights we possess or are pursuing generally cover our 
technologies to varying degrees. As a result, we cannot ensure that patents will issue from any of our patent applications, or that any of its issued 
patents will offer meaningful protection. In addition, our issued patents may be successfully challenged, invalidated, circumvented or rendered 
unenforceable so that our patent rights may not create an effective barrier to competition. Moreover, the laws of some foreign countries may not 
protect our proprietary rights to the same extent, as do the laws of the United States. There can be no assurance that any patents issued to us will 
provide a legal basis for establishing an exclusive market for our products or provide us with any competitive advantages, or that patents of 
others will not have an adverse effect on our ability to do business or to continue to use our technologies freely.  

We may be subject to third parties filing claims that our technologies or products infringe on their intellectual property. We cannot predict 

whether third parties will assert such claims against us or whether those claims will hurt our business. If we are forced to defend against such 
claims, regardless of their merit, we may face costly litigation and diversion of management’s attention and resources. As a result of any such 
disputes, we may have to develop, at a substantial cost, non-infringing technology or enter into licensing agreements. These agreements may be 
unavailable on terms acceptable to it, or at all, which could seriously harm our business or financial condition.  

We also rely on trade secret protection of our intellectual property. We attempt to protect trade secrets by entering into confidentiality 
agreements with third parties, employees and consultants, although, in the past, we have not always obtained such agreements. It is possible that 
these agreements may be breached, invalidated or rendered unenforceable, and if so, our trade secrets could be disclosed to our competitors. 
Despite the measures we have taken to protect our intellectual property, parties to such agreements may breach confidentiality provisions in our 
contracts or infringe or misappropriate our patents, copyrights, trademarks, trade secrets and other proprietary rights. In addition, third parties 
may independently discover or invent competitive technologies, or reverse engineer our trade secrets or other technology. Therefore, the 
measures we are taking to protect our proprietary technology may not be adequate.  

Customers and Distribution  

As a result of growing globalization, including such areas as biotechnology and life science, clinical trials, distribution of pharmaceutical 
products and reproductive medicine, the requirement for effective and reliable solutions for keeping clinical samples, pharmaceutical products 
and other specimen at frozen temperatures takes on added significance due to more complex shipping routes, extended shipping times, custom 
delays and logistics challenges. Today, such specimens are traditionally shipped in styrofoam cardboard insulated containers packed with dry 
ice, gel/freezer packs or a combination thereof. The current dry ice solutions have limitations that severely limit their effective use for both short 
and long-distances (e.g., international). Conventional dry ice shipments often require labor-intensive “re-icing” operations resulting in higher 
labor and shipping costs.  

With proper marketing and sales initiatives, we believe our patented cryogenic shippers and the Cryoportal logistics management platform 

make us well positioned to take advantage of the growing demand for effective and efficient international transport of temperature sensitive 
materials resulting from continued globalization. Of particular significance is the trend within the life sciences and biotechnology industries 
toward globalization. We believe that pharmaceutical companies conducting clinical trials in foreign countries represent a growing opportunity 
for Cryoport.  

We provide domestic shipping solutions in situations where specimen must be kept at cryogenic temperatures and in regions where there is 

a high priority placed on maintaining the integrity of materials shipped at cryogenic temperatures.  

Pharmaceutical Clinical Trials . Every United States based pharmaceutical company developing a new drug must seek drug development 

protocol approval by the FDA. These clinical trials are to, among other things, test the safety and efficacy of the potential new drug. A 
significant amount of clinical trial activity is managed by a number of large Clinical Research Organizations (“CROs”).  

8 

   
   
   
   
   
   
   
   
   
   
  
In connection with the clinical trials, due to globalization, the companies can be enrolled from all over the world and may regularly submit 
a blood or other specimen at the local hospital, doctor’s office or laboratory. These samples are then sent to specified testing laboratories, which 
may be local or in another country. The testing laboratories will typically set the requirements for the storage and shipment of blood specimens. 
In addition, drugs used by the patients may require frozen shipping to the sites of the clinical trials. While both domestic and international 
shipping of these specimens is accomplished using dry ice today, international shipments especially present several problems, as dry ice, under 
the best of circumstances, can only provide freezing for one to two days, in the absence of re-icing (which is quite costly). Because shipments of 
packages internationally can take longer than one to two days or be delayed due to flight cancellations, incorrect destinations, labor problems, 
ground logistics, customs delays and safety reasons, dry ice is not always a reliable and/or cost effective option. Clinical trial specimens are often 
irreplaceable because each one represents clinical data at a prescribed point in time, in a series of specimens on a given patient, who may be 
participating in a trial for years. Sample integrity during the shipping process is vital to retaining the maximum number of patients in each trial. 
Our shippers are ideally suited for this market, as our longer hold time ensures that specimens can be sent over long distances with minimal 
concern that they will arrive in a condition that will cause their exclusion from the trial. There are also many instances in domestic shipments 
where Cryoport Express ® Shippers will provide higher reliability and be cost effective.  

Furthermore, the IATA requires that all airborne shipments of laboratory specimens be transmitted in either IATA Instruction 650 or 602 

certified packaging. We have developed and obtained IATA certification of our Cryoport Express ® System, which is ideally suited for this 
market, in particular due to the elimination of the cost to return the reusable shipper.  

Biotechnology and Diagnostic Companies . The biotechnology market includes basic and applied research and development in diverse 
areas such as stem cells, cloning, gene therapy, DNA tumor vaccines, tissue engineering, genomics, and blood products. Companies participating 
in the foregoing fields rely on the frozen transport of specimens in connection with their research and development efforts, for which our 
Cryoport Express ® Shippers are ideally suited.  

Central Laboratories. With the increase and globalization of clinical studies and trials, logistics has become more complex and ensuring 
sample integrity has become more challenging. International courier costs are now consuming a significant portion of global protocol budgets. 
We believe laboratories performing the testing of samples collected during the conduct of these global multi-site studies are looking for reliable 
state-of-the-art logistics solutions.  

Pharmaceutical Distribution . The current focus for the Cryoport Express ® System also includes the area of pharmaceutical distribution. 

There are a significant number of therapeutic drugs and vaccines currently or anticipated soon to be, undergoing clinical trials. After the FDA 
approves them for commercial marketing, it will be necessary for the manufacturers to have a reliable and economical method of distribution to 
the physician who will administer the product to the patient. It is likely that the most efficient and reliable method of distribution will be to ship a 
single dosage to the administering physician. These drugs are typically identified to individual patients and therefore will require a complete 
tracking history from the manufacturer to the patient. The most reliable method of doing this is to ship a unit dosage specifically for each patient. 
If such drugs require maintenance at frozen or cryogenic temperatures, each such shipment will require a frozen or cryogenic shipping package. 
Cryoport can provide the technology to meet this anticipated need.  

9 

   
   
   
   
   
   
  
Fertility Clinics and In Vitro Fertilization (“IVF”) . Maintaining cryogenic temperatures during shipping and transfer of in vitro 
fertilization specimens like eggs, sperm, or embryos is critical for cell integrity in order to retain viability, stabilize the cells, and ensure 
reproducible results and successful IVF treatment. There are approximately 3,000 fertility clinics worldwide. Cryoport anticipates that this 
market will continue to grow; in the United States alone, the fertility market has grown to over $4.0 billion with over 1.3 million women seeking 
treatment each year. In the worldwide market, it is reported that there are over one billion IVF cycles per year and growing.  

Sales and Marketing  

We currently have two senior sales directors and one area sales manager in the United States, one senior sales director in Europe, one 
inside sales representative for IVF and a part time senior director of marketing promoting the use of our Cryoport Express ® System on a direct 
basis. Given the global nature of our business, our sales and marketing initiatives should more thoroughly cover the Americas, Europe and Asia. 
For the fiscal year ended March 31, 2013, no customers account for more than 10% of total revenues.  

Our geographical revenues for the fiscal year ended March 31, 2013 were as follows:  

USA 
Europe 
Asia 
Rest of World 

58.2 % 
20.2 % 
14.4 % 
7.2 % 

We renewed our agreement with FedEx and plan to further expand our revenues and marketing efforts through the establishment of 

additional strategic partnerships with global integrators and freight forwarders and, subject to available financial resources, the hiring of 
additional marketing and sales personnel.  

Cryoport Operations Centers  

In addition to the services provided through our facility in Lake Forest, California, we have contracted with third parties to run our 
European Operations Center (located in Leiden, Holland) and Asian Operations Center (located in Singapore). The operations centers provide 
warehousing, shipping, receiving, refurbishing and recycling services for our shipping containers. This approach is a cost-effective way to 
initiate operations outside of the US and allows us to scale up as our business grows globally. In March 2013, we shut down a small third-party 
operations center in New Delhi, India without impact on our business or customers.  

Industry and Competition  

Our products and services are sold into a rapidly growing segment of the logistics industry focused on the temperature sensitive packaging 

and shipping of biological materials. Expenditures for “value added” packaging for frozen transport have been increasing for the past several 
years and, due in part to continued globalization, are expected to continue to increase even more in the future as more domestic and international 
biotechnology firms introduce pharmaceutical products that require continuous refrigeration at cryogenic temperatures. We believe this will 
require a greater dependence on passively controlled temperature transport systems (i.e., systems having no external power source). In addition, 
we expect that industry standards and regulations will be introduced globally, requiring more comprehensive tracking and validation of shipping 
temperatures.  

We believe that growth in the following markets has resulted in the need for increased reliability, efficiencies and greater flexibility in the 

temperature sensitive segment of the logistics market:  

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

gene and stem cell biotechnology; 

cell lines; 

vaccine production; 

commercial drug product distribution; 

clinical trials, including transport of tissue culture samples; 

diagnostic specimens; 

infectious sample materials; 

inter/intra-laboratory diagnostic testing; 

temperature-sensitive specimens; 

biological samples, in general; 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
    
    
    
    
• 

environmental sampling; 

10 

   
   
• 

• 

IVF; and 

animal husbandry. 

Many of the biological products in these above markets require transport in a frozen state as well as the need for shipping containers which 
have the ability to maintain a frozen, cryogenic environment (e.g., minus 150° Celsius) for a period ranging from two to ten days (depending on 
the distance and mode of shipment). These products include stem cells, semen, embryo, tissue, tissue cultures, cultures of viruses and bacteria, 
enzymes, DNA materials, vaccines, certain pharmaceutical products, etc.  

The following comparisons apply only to the hardware portion of our solutions; our entire solutions integrate hardware, software and cold 

chain logistics know-how tailored to client requirements.  

Cryoport Express Shippers (Liquid Nitrogen Dry Vapor) compared to Dry Ice Shipments  

One problem faced by many companies operating in these specialized markets is the limited number of cryogenic shipping systems 
serving their needs. The currently adopted protocol and the most common method for packaging frozen transport in these industries is the use of 
solid-state carbon dioxide (dry ice). Dry ice is and has been used extensively in shipping to maintain a frozen state for a period of one to four 
days. Dry ice is used in the transport of many biological products, such as pharmaceuticals, laboratory specimens and certain infectious 
materials. The common approach to shipping these items via ground freight is to pack the product in a container, such as an expanded 
polystyrene (styrofoam) box or a molded polyurethane box, with a variable quantity of dry ice. The box is taped or strapped shut and shipped to 
its destination with freight charges based on its initial shipping weight. All dry ice shipping is considered dangerous goods shipping, requiring 
extra packaging steps and adding costs. It gives off carbon dioxide and sublimates unevenly and in short duration.  

With respect to shipments via specialized courier services, there is no standardized method or device currently in use for the purpose of 
transporting temperature-sensitive frozen biological specimens. One common method for courier transport of biological materials is to place 
frozen specimens, refrigerated specimens, and ambient specimens into a compartmentalized container, similar in size to a 55 quart Coleman or 
Igloo cooler. The freezer compartment in the container is loaded with a quantity of dry ice at minus 78° Celsius, while the refrigerated 
compartment at 8° Celsius utilizes ice substitutes.  

Two manufacturers of the polystyrene and polyurethane containers frequently used in the shipping and courier transport of dry ice frozen 

specimens are Insulated Shipping Containers, Inc. and Tegrant (formerly SCA Thermosafe). When these containers are used with dry ice, the 
average sublimation rate (e.g., the rate at which dry ice turns from a solid to a gaseous state) in a container with a 1 1 / 2 inch wall thickness is 
slightly less than three pounds per 24 hours. Other existing refrigerant systems employ the use of gel packs and ice substitutes for temperature 
maintenance. Gels and eutectic solutions (phase changing materials) with a wide range of phasing temperatures have been developed in recent 
years to meet the needs of products with varying specific temperature control requirements.  

The use of dry ice and ice substitutes, however, regardless of external packaging used, are frequently inadequate because they do not 
provide low enough storage temperatures and, in the case of dry ice, last for only a few days without re-icing. As a result, companies run the risk 
of increased costs due to lost specimens and additional shipping charges due to the need to re-ice.  

Some of the other disadvantages to using dry ice for shipping or transporting temperature sensitive products are as follows:  

• 

• 

• 

• 

• 

availability of a dry ice source; 

handling and storage of the dry ice; 

cost of the dry ice; 

compliance with local, state and federal regulations relating to the storage and use of dry ice; 

dangerous goods shipping regulations; 

•  weight of containers when packed with dry ice; 

• 

• 

• 

securing a shipping container with a high enough R-value (which is a measure of thermal resistance) to hold the dry ice and product 
for the required time period; 

securing a shipping container that meets the requirements of IATA, the DOT, the CDC, and other regulatory agencies; and 

emission of greenhouse gases (primarily carbon dioxide) into the environment. 

Due to the limitations of dry ice, specimens that require frozen shipping are more securely shipped at true cryogenic temperatures using a 

service such as liquid nitrogen dry vapor shippers (Cryoport Express Shippers) , or liquid nitrogen shippers where the specimen is kept over 
actual liquid nitrogen. However, liquid nitrogen is hazardous and has many pitfalls including safety and expense.  

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
11 

   
Cryoport Express Shippers (Liquid Nitrogen Dry Vapor) compared to Liquid Nitrogen Dewars/Tanks  

There are distinct disadvantages when using liquid nitrogen compared to the dry vapor liquid nitrogen used in Cryoport Express ® 
Shippers. Liquid nitrogen dewars/tanks are classified as dangerous goods and cannot be shipped as parcel. In addition, the liquid nitrogen has to 
be disposed of prior to returning the dewar/tank to its origin. These issues add additional procedural steps and costs to the shipment. In addition, 
there is a risk of liquid nitrogen leakage if the dewar/tank tips to the side during transport, which can cause bodily injury and compromise the 
specimen being shipped. Due to the use of our proprietary technology, our Cryoport Express ® Shippers are not prone to leakage when on their 
side or inverted, thereby protecting the integrity of our shipper’s hold time and being safe for handling.  

While both, liquid nitrogen dry vapor and liquid nitrogen shippers provide solutions to the issues encountered when shipping with dry ice, 

liquid nitrogen shippers have some draw backs. For example, the cost for a liquid nitrogen shipper typically can range from $650 to $4,000 per 
unit, which can substantially limit their use for the transport of many common biologics, particularly with respect to small quantities such as is 
the case with direct to the physician drug delivery. Because of the initial cost and limited production of these containers, they are designed to be 
reusable. However, the cost of returning these containers can be significant, particularly in international markets, because most applications 
require only one-way shipping. In addition, the logistics support of cryogenic shippers requires more sophisticated logistics management and 
discipline to ensure shippers are returned and recycled, especially for international shipments, which many companies do not have in place.  

Cryoport’s solutions are totally comprehensive and integrated for maximum reliability, economy and total effectiveness. Cryoport’s total 

logistics solution enables life sciences companies to utilize the superior liquid nitrogen dry vapor technology without having to make capital 
investments or developing in-house logistics expertise and systems by offering a complete solution which includes the cloud-based Cryoportal 
logistics management platform, the temperature monitoring system and the 24/7/365 logistics support. Cryoport allows the customer to 
outsource logistics and focus on its core competencies while maintaining visibility of all shipping related information.  

Within our intended biotechnology and life sciences markets for Cryoport Express ® Shippers, there is limited known direct competition. 

We compete with liquid nitrogen and dry ice solutions by reason of the improved and integrated hardware and software technology in our 
products including our comprehensive logistics management software and through the use of our service enabled business model. The Cryoport 
Express ® Solution provides a simple and cost effective solution for the frozen or cryogenic transport of biotech and life sciences materials. The 
Cryoportal assist the management, scheduling and shipping of the Cryoport Express ® Shippers removing the burdens associated with other 
methods.  

Traditional dry ice shippers and liquid nitrogen tank suppliers, such as MVE/Chart Industries, Taylor Wharton and Air Liquide, offer 

various models of dry vapor liquid nitrogen shippers that are not as cost efficient for multi-use and multi-shipment purposes due to their 
significantly greater unit costs and unit weight (which may substantially increase the shipping cost). On the other hand, they are more established 
and have larger organizations and have greater financial, operational, sales and marketing resources, have a broad manufactured product offering 
of other liquid nitrogen products and experience in research and development than we do.  

Factors that we believe give us a competitive advantage are attributable to our software and shipping container which allows our shipper to 

retain liquid nitrogen when placed in non-upright positions, the overall “leak- proofness” of our package which determines compliance with 
shipping regulations and the overall weight and volume of the package which determines shipping costs, and our business model represented by 
the merged integration of our shipper with Cryoportal and Smart Pak datal ogger into a seamless shipping, tracking and monitoring solution.  

Other companies that offer potentially competitive products include Industrial Insulation Systems, which offers cryogenic transport units 

and has partnered with Marathon Products Inc., a manufacturer and global supplier of wireless temperature data collecting devices used for 
documenting environmentally sensitive products through the cold chain and Kodiak Thermal Technologies, Inc. which offers, among other 
containers, a repeat use active-cool container that uses free piston stirling cycle technology. While not having their own shipping devices, 
BioStorage Technologies is potentially a competitive company through their management services offered for cold-chain logistics and long-term 
biomaterial storage. Cryogena offers a single use disposable LN2 shipper with better performance than dry ice, but it does not perform as well 
and is not as cost-effective as the Cryoport solution when all costs are considered. In addition, BioMatrica, Inc. is developing and offering 
technology that stabilizes biological samples and research materials at room temperature. They presently offer these technologies primarily to 
research and academic institutions; however, their technology may eventually enter the broader cold-chain market.  

12 

   
   
   
   
   
   
   
   
   
  
Research and Development  

Our research and development efforts are focused on continually improving the features of our Cryoport Express ® Solutions including the 

cloud-based Cryoportal and the Cryoport Express ® Shippers. These efforts are expected to lead to the introduction of shippers of varying sizes 
based on market requirements, constructed of lower cost materials and utilizing high volume manufacturing methods that will make it practical 
to provide the cryogenic packages offered by the Cryoport Express ® System. Alternative phase change materials in place of liquid nitrogen may 
be used to increase the potential markets these shippers can serve such as ambient and 2-8°C markets. Our research and development 
expenditures for the fiscal years ended March 31, 2013 and 2012 were $425,446 and $491,849, respectively with the largest portion being spent 
on software maintenance and development.  

Employees  

As of June 17, 2013, we had seventeen full-time employees, one consultant and two temporary employees.  

Insurance  

We currently maintain general liability insurance, with coverage in the amount of $1 million per occurrence, subject to a $2 million annual 

limitation. Claims may be made against us that exceed these limits. In fiscal year 2013, we did not experience any claims against our 
professional liability insurance. Our liability policy is an “occurrence” based policy. Thus, our policy is complete when we purchased it and 
following cancellation of the policy it continues to provide coverage for future claims based on conduct that took place during the policy term. 
However, our insurance may not protect us against liability because our policies typically have various exceptions to the claims covered and also 
require us to assume some costs of the claim even though a portion of the claim may be covered. In addition, if we expand into new markets, we 
may not be aware of the need for, or be able to obtain insurance coverage for such activities or, if insurance is obtained, the dollar amount of any 
liabilities incurred could exceed our insurance coverage. A partially or completely uninsured claim, if successful and of significant magnitude, 
could have a material adverse effect on our business, financial condition and results of operations.  

We also maintain product liability insurance with coverage in the amount of $1,000,000 per year. In addition, we currently maintain cargo 

insurance for shipments for one customer, with coverage of up to $10,000 per shipment.  

ITEM 1A.  RISK FACTORS 

This Annual Report on Form 10-K contains forward-looking information based on our current expectations. Because our actual results 
may differ materially from any forward-looking statements made by or on behalf of Cryoport, this section includes a discussion of important 
factors that could affect our actual future results, including, but not limited to, our potential product and service revenues, acceptance of our 
products and services, expenses, net income(loss) and earnings(loss) per common share.  

Risks Related to Our Business  

We have incurred significant losses to date and may continue to incur losses.  

We have incurred net losses in each fiscal year since we commenced operations. The following table represents net losses incurred for 

each of our last two fiscal years:  

Fiscal Year Ended March 31, 2013 
Fiscal Year Ended March 31, 2012 

   Net Loss 
  $ 
  $ 

6,382,433   
7,832,928   

As of March 31, 2013, we had an accumulated deficit of $66,311,448. While we expect to continue to derive revenues from our current 

products and services, in order to achieve and sustain profitable operations, we must successfully commercialize and launch our Cryoport 
Express ® solution, significantly expand our market presence and increase revenues. We may continue to incur losses in the future and may 
never generate revenues sufficient to become profitable or to sustain profitability. Continuing losses may impair our ability to raise the additional 
capital required to continue and expand our operations.  

Our auditors have expressed doubt about our ability to continue as a going concern.  

The Report of Independent Registered Public Accounting Firm to our March 31, 2013 consolidated financial statements includes an 
explanatory paragraph stating that the recurring losses and negative cash flows from operations since inception and our cash and cash equivalent 
balance at March 31, 2013 raise substantial doubt about our ability to continue as a going concern. The consolidated financial statements do not 
include any adjustments that might result from the outcome of this uncertainty.  

If we are unable to obtain additional funding, we may have to reduce or discontinue our business operations.  

As of June 17, 2013, we had cash and cash equivalents of $146,057. We have expended substantial funds developing and commercializing 

our Cryoport Express ® Solutions and for general operating expenses. As a result, we have historically experienced negative cash flows from 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
operations and we expect to continue to experience negative cash flows from operations in the future. Therefore, our ability to continue 

and expand our operations is highly dependent on the amount of cash and cash equivalents on hand combined with our ability to raise additional 
capital to fund future operations.  

13 

We are currently funding our operations through short-term bridge financing and plan to raise additional funds through an equity or debt 

offering to cover general working capital needs and sales and marketing initiatives to expand our customer base and increase revenues. If we are 
not able to raise sufficient funds and our projected revenues and cash-inflows are reduced or delayed, we may not have sufficient capital to 
operate through the secondquarter of our fiscal year 2014 or beyond. We are currently exploring various arrangements with respect to securing 
additional funding. However, there can be no assurance that any additional financing on commercially reasonable terms, or at all, will be 
available when needed. The inability to obtain additional capital may reduce our ability to continue to conduct our business operations. Any 
additional equity financing will involve substantial dilution to our then existing stockholders. The uncertainties surrounding our future cash 
inflows have raised substantial doubt regarding our ability to continue as a going concern.  

If we are not successful in establishing strategic relationships with global couriers, we may not be able to successfully increase revenues 
and cash flow which could adversely affect our operations.  

We believe that establishing strategic relationships with global couriers, such as our agreements with FedEx and DHL can drive growth. 

Such relationships will enable us to provide a seamless, end-to-end shipping solution to customers and allow us to leverage the couriers’ 
established express, ground and freight infrastructures and penetrate new markets with minimal investment. Further, we expect that the global 
couriers will utilize their sales forces to promote and sell our frozen shipping services. If we are not successful in launching our relationship with 
FedEx or DHL or establishing additional relationships with global couriers, our sales and marketing efforts will be significantly impacted and 
anticipated revenue growth will be delayed which could adversely impact on our operations.  

Our agreements with FedEx and DHL may not result in a significant increase in our revenues or cash flow.  

In January 2013, we entered into a master agreement with FedEx , renewing FedEx’s right to on a non-exclusive basis, promote, market 

and sell transportation of our shippers and our related value-added goods and services and providing FedEx with a non-exclusive license and 
right to use a customized version of our Cryoportal for the management of shipments made by FedEx customers. Because our agreement with 
FedEx does not contain any requirement that FedEx lease a minimum number of shippers from us during the term of the agreement, we may not 
experience a significant increase in our revenues or cash flows as a result of this agreement. On September 2, 2010, we entered into an 
agreement with DHL that will give DHL life sciences customers direct access to our web-based order entry and tracking portal to order our 
Cryoport Express ® Shippers and preferred DHL shipping rates. Although the agreement provides shipping discounts that may be used to support 
our customers using our Cryoport Express ® Solution, DHL will not be promoting, marketing or selling transportation of our shippers or 
services, which may not lead to any increase in our revenues.  

Current economic conditions and capital markets are in a period of disruption and instability which could adversely affect our ability to 
access the capital markets, and thus adversely affect our business and liquidity.  

The current economic conditions and financial crisis have had, and will continue to have, a negative impact on our ability to access the 
capital markets, and thus have a negative impact on our business and liquidity. The shortage of liquidity and credit combined with substantial 
losses in worldwide equity markets could lead to an extended worldwide recession. We may face significant challenges if conditions in the 
capital markets do not improve and we do not achieve positive cash flow from operations. Our ability to access the capital markets may be 
severely restricted at a time when we need to access such markets, which could have a negative impact on our business plans, including the 
commercialization and launch of our Cryoport Express ® Solution and other research and development activities. Even if we are able to raise 
capital, it may not be at a price or on terms that are favorable to us. We cannot predict the occurrence of future financial disruptions or how long 
the current market conditions may continue.  

The sale of substantial shares of our common stock may depress our stock price.  

As of June 17, 2013, there were 38,260,628 shares of our common stock outstanding. Substantially all of these shares of common stock are 

eligible for trading in the public market. The market price of our common stock may decline if our stockholders sell a large number of shares of 
our common stock in the public market, or the market perceives that such sales may occur.  

14 

   
   
   
   
   
   
   
   
   
  
We could also issue up to 44,663,099 shares of our common stock including shares to be issued upon the exercise of outstanding warrants 

and options or reserved for future issuance under our stock incentive plans, as further described in the following table:  

Common stock issuable upon exercise of outstanding warrants 
Common stock issuable upon exercise of outstanding options or reserved for future incentive 

awards under our stock incentive plans 

Total 

Number of  
Shares of  
Common Stock 
Issuable or  
Reserved for  
Issuance 

37,027,198   

7,635,901   

44,663,099   

Of the total options and warrants outstanding as of March 31, 2013, options and warrants exercisable for an aggregate of 2,626,977 shares 
of common stock would be considered dilutive to the value of our stockholders’ interest in Cryoport because we would receive upon exercise of 
such options and warrants an amount per share that is less than the market price of our common stock on March 31, 2013.  

We will have difficulty increasing our revenues if we experience delays, difficulties or unanticipated costs in establishing the sales, 
distribution and marketing capabilities necessary to successfully commercialize our products.  

We are continuing to develop sales, distribution and marketing capabilities in the Americas, Europe and Asia. It will be expensive and 

time-consuming for us to develop a global marketing and sales network. Moreover, we may choose, or find it necessary, to enter into additional 
strategic collaborations to sell, market and distribute our products. We may not be able to provide adequate incentive to our sales force or to 
establish and maintain favorable distribution and marketing collaborations with other companies to promote our products. In addition, any third 
party with whom we have established a marketing and distribution relationship may not devote sufficient time to the marketing and sales of our 
products thereby exposing us to potential expenses in exiting such distribution agreements. We, and any of our third party collaborators, must 
also market our products in compliance with federal, state, local and international laws relating to the provision of incentives and inducements. 
Violation of these laws can result in substantial penalties. Therefore, if we are unable to successfully motivate and expand our marketing and 
sales force and further develop our sales and marketing capabilities, or if our distributors fail to promote our products, we will have difficulty 
increasing our revenues.  

Our ability to grow and compete in our industry will be hampered if we are unable to retain the continued service of our key professionals 
or to identify, hire and retain additional qualified professionals.  

A critical factor to our business is our ability to attract and retain qualified professionals including key employees and consultants. We are 

continually at risk of losing current professionals or being unable to hire additional professionals as needed. If we are unable to attract new 
qualified employees, our ability to grow will be adversely affected. If we are unable to retain current employees or strategic consultants, our 
financial condition and ability to maintain operations may be adversely affected.  

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We are dependent on new products and services, the lack of which would harm our competitive position.  

Our future revenue stream depends to a large degree on our ability to bring new products and services to market on a timely basis. We 

must continue to make significant investments in research and development in order to continue to develop new products and services, enhance 
existing products and services, and achieve market acceptance of such products and services. We may incur problems in the future in innovating 
and introducing new products and services. Our development stage products and services may not be successfully completed or, if developed, 
may not achieve significant customer acceptance. If we are unable to successfully define, develop and introduce new, competitive products and 
services and enhance existing products and services, our future results of operations would be adversely affected. Development and 
manufacturing schedules for technology products and services are difficult to predict, and we might not achieve timely initial customer 
shipments of new products or launch of services. The timely availability of these products and services and their acceptance by customers are 
important to our future success. A delay in new or enhanced product or service introductions could have a significant impact on our results of 
operations.  

Because of these risks, our research and development efforts may not result in any commercially viable products or services. If significant 

portions of these development efforts are not successfully completed, or any new or enhanced products or services are not commercially 
successful, our business, financial condition and results of operations may be materially harmed.  

If we successfully develop products and/or services, but those products and/or services do not achieve and maintain market acceptance, 
our business will not be profitable.  

The degree of acceptance of our Cryoport Express ® Solutions and/or Cryoport Express ® Shippers, or any future product or services, by 

our current target markets, and any other markets to which we attempt to sell our products and services, and our profitability and growth will 
depend on a number of factors including, among others:  

• 

• 

• 

• 

• 

• 

our shippers’ ability to perform and preserve the integrity of the materials shipped; 

relative convenience and ease of use of our shipper and/or Cryoportal; 

availability of alternative products; 

pricing and cost effectiveness; 

effectiveness of our or our collaborators’ sales and marketing strategy; and 

the adoption cycles of our targeted customers. 

If any products or services we may develop do not achieve market acceptance, then we may not generate sufficient revenue to achieve or 

maintain profitability.  

In addition, even if our products and services achieve market acceptance, we may not be able to maintain that market acceptance over time 
if new products or services are introduced that are more favorably received than our products and services, are more cost effective, or render our 
products obsolete.  

The product adoption cycle of our target customers tends to be very lengthy, which continues to adversely affect our ability to increase 
revenues.  

We offer our solution primarily to companies in the life sciences industry. These companies operate within a heavily regulated 
environment and as such, changing vendors and distribution practices typically require a number of steps which may include the audit of our 
facilities, review of our procedures, qualifying us as a vendor, and performing test shipments. This process can take several months or longer to 
complete prior to a company fully adopting the Cryoport Express ® Solution. In addition, any such adoption may be on a gradual basis such that 
the customer progressively ramps up use of our Cryoport Express ® Solution following adoption. The slow adoption process continues to 
adversely affect our ability to increase revenues.  

We are dependent on an outside party for the continued development of our Cryoportal  

Our proprietary Cryoportal is a software system used by our customers and business partners to automate the entry of orders, prepare 

customs documentation and facilitate status and location monitoring of shipped orders while in transit. The continued development of this 
system is contracted with an outside software development company. If this developer becomes unable or unwilling to continue work on 
scheduled projects, and an alternative developer cannot be secured, we may not be able to implement needed enhancements to the system. 
Furthermore, if we terminate our agreement with this developer and cannot reach an agreement or fail to fulfill an agreement for the termination, 
we could lose our license to use this software. Failure to proceed with enhancements or the loss of our license for the system would adversely 
affect our ability to generate new business and serve existing customers, resulting in a reduction in revenue.  

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
16 

Our success depends, in part, on our ability to obtain patent protection for our products and business model, preserve our trade secrets, 
and operate without infringing the proprietary rights of others.  

Our policy is to seek to protect our proprietary position by, among other methods, filing United States patent applications related to our 

technology, inventions and improvements that are important to the development of our business. We have three issued U.S. patents and one 
recently filed provisional patent application, all relating to various aspects of our products and services. Our patents or provisional patent 
application may be challenged, invalidated or circumvented in the future or the rights granted may not provide a competitive advantage. We 
intend to vigorously protect and defend our intellectual property. Costly and time-consuming litigation brought by us may be necessary to 
enforce our patents and to protect our trade secrets and know-how, or to determine the enforceability, scope and validity of the proprietary rights 
of others.  

We also rely upon trade secrets, technical know-how and continuing technological innovation to develop and maintain our competitive 

position. In the past our employees, consultants, advisors and suppliers have not always executed confidentiality agreements and invention 
assignment and work for hire agreements in connection with their employment, consulting, or advisory relationships. Consequently, we may not 
have adequate remedies available to us to protect our intellectual property should one of these parties attempt to use our trade secrets or refuse to 
assign any rights he or she may have in any intellectual property he or she developed for us. Additionally, our competitors may independently 
develop substantially equivalent proprietary information and techniques or otherwise gain access to our proprietary technology, or we may not 
be able to meaningfully protect our rights in unpatented proprietary technology.  

We cannot assure you that our current and potential competitors and other third parties have not filed (or in the future will not file) patent 

applications for (or have not received or in the future will not receive) patents or obtain additional proprietary rights that will prevent, limit or 
interfere with our ability to make, use or sell our products either in the United States or internationally. In the event we are required to license 
patents issued to third parties, such licenses may not be available or, if available, may not be available on terms acceptable to us. In addition, we 
cannot assure you that we would be successful in any attempt to redesign our products or processes to avoid infringement or that any such 
redesign could be accomplished in a cost-effective manner. Accordingly, an adverse determination in a judicial or administrative proceeding or 
failure to obtain necessary licenses could prevent us from manufacturing and selling our products or offering our services, which would harm our 
business.  

We are not aware of any third party that is infringing any of our patents or trademarks nor do we believe that we are infringing on the 

patents or trademarks of any other person or organization.  

Our products may contain errors or defects, which could result in damage to our reputation, lost revenues, diverted development resources 
and increased service costs and litigation.  

Our products must meet stringent requirements and we must develop our products quickly to keep pace with the rapidly changing market. 
Products and services as sophisticated as ours could contain undetected errors or defects, especially when first introduced or when new models 
or versions are released. In general, our products may not be free from errors or defects after commercial shipments have begun, which could 
result in damage to our reputation, lost revenues, diverted development resources, increased customer service and support costs, and litigation. 
The costs incurred in correcting any product errors or defects may be substantial and could adversely affect our business, results of operations 
and financial condition.  

If we experience manufacturing delays or interruptions in production, then we may experience customer dissatisfaction and our 
reputation could suffer.  

If we fail to produce enough shippers at our own manufacturing facility or at a third party manufacturing facility, or if we fail to complete 

our shipper recycling processes as planned, we may be unable to deliver shippers to our customers on a timely basis, which could lead to 
customer dissatisfaction and could harm our reputation and ability to compete. We currently acquire various component parts for our shippers 
from various independent manufacturers in the United States. We would likely experience significant delays or cessation in producing our 
shippers if a labor strike, natural disaster or other supply disruption were to occur at any of our main suppliers. If we are unable to procure a 
component from one of our manufacturers, we may be required to enter into arrangements with one or more alternative manufacturing 
companies which may cause delays in producing our shippers. In addition, because we depend on third party manufacturers, our profit margins 
may be lower, which will make it more difficult for us to achieve profitability. To date, we have not experienced any material delay that has 
adversely impacted our operations. As our business develops and the quantity of production increases, it becomes more likely that such problems 
could arise.  

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Because we rely on a limited number of suppliers, we may experience difficulty in meeting our customers’ demands for our products in a 
timely manner or within budget.  

We currently purchase key components of our products from a variety of outside sources. Some of these components may only be 
available to us through a few sources, however, management has identified alternative materials and suppliers should the need arise. We 
generally do not have long-term agreements with any of our suppliers. Consequently, in the event that our suppliers delay or interrupt the supply 
of components for any reason, we could potentially experience higher product costs and longer lead times in order fulfillment.  

Our Cryoportal may be subject to intentional disruption that could adversely impact our reputation and future revenues.  

We have implemented our Cryoportal which is used by our customers and business partners to automate the entry of orders, prepare 
customs documentation and facilitate status and location monitoring of shipped orders while in transit. Although we believe we have sufficient 
controls in place to prevent intentional disruptions, we could be a target of cyber attacks specifically designed to impede the performance of the 
Cryoportal. Similarly, experienced computer programmers may attempt to penetrate our Cryoportal in an effort to search for and misappropriate 
proprietary or confidential information or cause interruptions of our services. Because the techniques used by such computer programmers to 
access or sabotage networks change frequently and may not be recognized until launched against a target, we may be unable to anticipate these 
techniques. Our activities could be adversely affected and our reputation, brand and future sales harmed if these intentionally disruptive efforts 
are successful.  

Our products and services may expose us to liability in excess of our current insurance coverage.  

Our products and services involve significant risks of liability, which may substantially exceed the revenues we derive from them. We 

cannot predict the magnitude of these potential liabilities.  

We currently maintain general liability insurance, with coverage in the amount of $1 million per occurrence, subject to a $2 million annual 
limitation, and product liability insurance with a $1 million annual coverage limitation. Claims may be made against us that exceed these limits.  

Our liability policy is an “occurrence” based policy. Thus, our policy is complete when we purchased it and following cancellation of the 
policy it continues to provide coverage for future claims based on conduct that took place during the policy term. However, our insurance may 
not protect us against liability because our policies typically have various exceptions to the claims covered and also require us to assume some 
costs of the claim even though a portion of the claim may be covered. In addition, if we expand into new markets, we may not be aware of the 
need for, or be able to obtain insurance coverage for such activities or, if insurance is obtained, the dollar amount of any liabilities incurred could 
exceed our insurance coverage. A partially or completely uninsured claim, if successful and of significant magnitude, could have a material 
adverse effect on our business, financial condition and results of operations.  

Complying with certain regulations that apply to shipments using our products can limit our activities and increase our cost of operations. 

Shipments using our products and services are subject to various regulations in the countries in which we operate. For example, shipments 

using our products may be required to comply with the shipping requirements promulgated by the Centers for Disease Control (“CDC”), the 
Occupational Safety and Health Organization (“OSHA”), the Department of Transportation (“DOT”) as well as rules established by the 
International Air Transportation Association (“IATA”) and the International Civil Aviation Organization (“ICAO”). Additionally, our data 
logger may be subject to regulation and certification by the Food and Drug Administration (“FDA”), Federal Communications Commission 
(“FCC”), and Federal Aviation Administration (“FAA”). We will need to ensure that our products and services comply with relevant rules and 
regulations to make our products and services marketable, and in some cases compliance is difficult to determine. Significant changes in such 
regulations could require costly changes to our products and services or prevent use of our shippers for an extended period of time while we seek 
to comply with changed regulations. If we are unable to comply with any of these rule or regulations or fail to obtain any required approvals, our 
ability to market our products and services may be adversely affected. In addition, even if we are able to comply with these rules and regulations, 
compliance can result in increased costs. In either event, our financial results and condition may be adversely affected. We depend on our 
business partners and unrelated and frequently unknown third party agents in foreign countries to act on our behalf to complete the importation 
process and to make delivery of our shippers to the final user. The failure of these third parties to perform their duties could result in damage to 
the contents of the shipper resulting in customer dissatisfaction or liability to us, even if we are not at fault.  

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If we cannot compete effectively, we will lose business.  

Our products, services and solutions are positioned to be competitive in the cold-chain logistics market. While there are technological and 

marketing barriers to entry, we cannot guarantee that the barriers we are capable of producing will be sufficient to defend the market share we 
wish to gain against current and future competitors. Our principal competitive considerations in our market include:  

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

financial resources to allocate to proper marketing and an appropriate sales effort; 

acceptance of our solutions business model; 

acceptance of our services including per use fee structures; 

keeping up technologically with ongoing development of enhanced features and benefits 

reductions in the manufacturing cost of competitors’ products; 

the ability to develop and maintain and expand distribution channels; 

establishing our brand name; 

our ability to deliver our products to our customers when requested; 

our timing of introductions of new solutions, products and services; and 

financial resources to support working capital needs and required capital investments. 

Current and prospective competitors have substantially greater resources, more customers, longer operating histories, greater name 
recognition and more established relationships in the industry. As a result, these competitors may be able to develop and expand their networks 
and product offerings more quickly, devote greater resources to the marketing and sale of their products and adopt more aggressive pricing 
policies. In addition, these competitors have entered and will likely continue to enter into business relationships to provide additional products 
competitive to those we provide or plan to provide.  

We may not be able to compete with our competitors in the industry because many of them have greater resources than we do.  

We expect to continue to experience significant and increasing levels of competition in the future. In addition, there may be other 
companies which are currently developing competitive products and services or which may in the future develop technologies and products that 
are comparable, superior or less costly than our own. For example, some cryogenic equipment manufacturers with greater resources currently 
have solutions for storing and transporting cryogenic liquid and gasses and may develop storage solutions that compete with our products. 
Additionally, some specialty couriers with greater resources currently provide dry ice transportation and may develop other products in the 
future, both of which compete with our products. A competitor that has greater resources than us may be able to bring its product to market faster 
than we can and offer its product at a lower price than us to establish market share. We may not be able to successfully compete with a 
competitor that has greater resources and such competition may adversely affect our business.  

Risks Relating to Our Current Financing Arrangements  

Certain of our existing stockholders own and have the right to acquire a substantial number of shares of common stock.  

As of June 17, 2013, our directors, executive officers and beneficial owners of 5% or more of our outstanding common stock beneficially 

owned 9,365,085 shares of common stock (without regard to beneficial ownership limitations contained in certain warrants) assuming their 
exercise of all outstanding warrants, options or approximately 20.1% of our outstanding common stock. Of these shares of common stock, 
2,857,139 shares, or approximately 7.0% of our common stock, will be beneficially owned by CNH Partners, LLC, and 2,500,428 shares, or 
approximately 6.2% of our outstanding common stock, will be beneficially owned by Emergent Financial Group (each calculated without regard 
to the shares of common stock that may be acquired by the other upon the exercise of its warrants and conversion of debt). As such, the 
concentration of beneficial ownership of our common stock may have the effect of delaying or preventing a change in control of Cryoport and 
may adversely affect the voting or other rights of other holders of our common stock.  

Our stock and warrant price is and will continue to be volatile.  

The market price of our common stock has been and, along with the warrants is likely to be, highly volatile and could fluctuate widely in 

price in response to various factors, many of which are beyond our control, including, but not limited to:  

• 

technological innovations or new products and services by us or our competitors; 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
• 

• 

• 

• 

additions or departures of key personnel; 

sales of our common stock; 

our ability to integrate operations, technology, products and services; 

our ability to execute our business plan; 

19 

   
   
   
   
• 

• 

• 

• 

• 

operating results below expectations; 

loss of any strategic relationship; 

industry developments; 

economic and other external factors; and 

period-to-period fluctuations in our financial results. 

You may consider any one of these factors to be material. The price of our common stock and warrants may fluctuate widely as a result of 

any of the above listed factors. In addition, the securities markets have from time to time experienced significant price and volume fluctuations 
that are unrelated to the operating performance of particular companies. These market fluctuations may also materially and adversely affect the 
market price of our common stock and warrants.  

If equity research analysts do not publish research or reports about our business or if they issue unfavorable commentary or downgrade 
our common stock and warrants, the price of our common stock and warrants could decline.  

The trading market for our common stock and warrants relies in part on the research and reports that equity research analysts publish about 

us and our business. We do not control these analysts. The price of our common stock and warrants could decline if one or more equity analyst 
downgrades our stock or if analysts issue other unfavorable commentary or cease publishing reports about us or our business.  

We have not paid dividends on our common stock in the past and do not expect to pay dividends in the foreseeable future. Any return on 
investment may be limited to the value of our common stock.  

We have never paid cash dividends on our common stock and do not anticipate paying cash dividends in the foreseeable future. The 
payment of dividends on our common stock will depend on our earnings, financial condition and other business and economic factors affecting 
us at such time as the Board of Directors may consider the payment of any such dividends. If we do not pay dividends, our common stock may 
be less valuable because a return on your investment will only occur if the price of our common stock appreciates.  

We need additional capital, and the sale of additional shares of common stock or other equity securities could result in additional dilution 
to our stockholders.  

Our current cash and cash equivalents and anticipated cash flow from operations are insufficient to meet our cash needs. We require 
additional cash resources to fund our operations and may require additional funds in the future due to changed business conditions or other future 
developments, including any investments or acquisitions we may decide to pursue. The sale of additional equity securities, or debt securities 
convertible into equity securities, could result in additional dilution to our stockholders. The incurrence of indebtedness would result in increased 
debt service obligations and could result in operating and financing covenants that would restrict our operations.  

Our Articles of Incorporation allows our Board of Directors to issue up to 2,500,000 shares of “blank check” preferred stock.  

Our Articles of Incorporation allows our Board of Directors to issue up to 2,500,000 shares of “blank check” preferred stock, without 

action by our stockholders. Such shares of preferred stock may be issued on terms determined by our Board of Directors, and may have rights, 
privileges and preferences superior to those of our common stock. Without limiting the foregoing, (i) such shares of preferred stock could have 
liquidation rights that are senior to the liquidation preference applicable to our common stock, (ii) such shares of preferred stock could have 
voting or conversion rights, which could adversely affect the voting power of the holders of our common stock and (iii) the ownership interest of 
holders of our common stock will be diluted following the issuance of any such shares of preferred stock. In addition the issuance of such shares 
of blank check preferred stock could have the effect of discouraging, delaying or preventing a change of control of our Company.  

Provisions in our bylaws and Nevada law might discourage, delay or prevent a change of control of our Company or changes in our 
management and, as a result, may depress the trading price of our common stock.  

Provisions of our bylaws and Nevada law may discourage, delay or prevent a merger, acquisition or other change in control that 
stockholders may consider favorable, including transactions in which you might otherwise receive a premium for your shares of our common 
stock. The relevant bylaw provisions may also prevent or frustrate attempts by our stockholders to replace or remove our management. These 
provisions include advance notice requirements for stockholder proposals and nominations, and the ability of our Board of Directors to make, 
alter or repeal our bylaws.  

Absent approval of our Board of Directors, our bylaws may only be amended or repealed by the affirmative vote of the holders of at least a 

majority of our outstanding shares of capital stock entitled to vote.  

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In addition, Section 78.438 of the Nevada Revised Statutes prohibits a publicly-held Nevada corporation from engaging in a business 

combination with an interested stockholder (generally defined as a person which together with its affiliates owns, or within the last three years 
has owned, 10% of our voting stock, for a period of three years after the date of the transaction in which the person became an interested 
stockholder) unless the business combination is approved in a prescribed manner.  

The existence of the foregoing provisions and other potential anti-takeover measures could limit the price that investors might be willing to 
pay in the future for shares of our common stock. They could also deter potential acquirers of our Company, thereby reducing the likelihood that 
you could receive a premium for your common stock in an acquisition.  

Even though we are not incorporated in California, we may become subject to a number of provisions of the California General 
Corporation Law.  

Section 2115(b) of the California Corporations Code imposes certain requirements of California corporate law on corporations organized 
outside California that, in general, are doing more than 50% of their business in California and have more than 50% of their outstanding voting 
securities held of record by persons residing in California. While we are not currently subject to Section 2115(b), we may become subject to it in 
the future.  

The following summarizes some of the principal differences which would apply if we become subject to Section 2115(b).  

Under both Nevada and California law, cumulative voting for the election of directors is permitted. However, under Nevada law 

cumulative voting must be expressly authorized in the Articles of Incorporation and our Amended and Restated Articles of Incorporation do not 
authorize cumulative voting. If we become subject to Section 2115(b), we may be required to permit cumulative voting if any stockholder 
properly requests to cumulate his or her votes.  

Under Nevada law, directors may be removed by the stockholders only by the vote of two-thirds of the voting power of the issued and 
outstanding stock entitled to vote. However, California law permits the removal of directors by the vote of only a majority of the outstanding 
shares entitled to vote. If we become subject to Section 2115(b), the removal of a director may be accomplished by a majority vote, rather than a 
vote of two-thirds, of the stockholders entitled to vote.  

Under California law, the corporation must take certain steps to be allowed to provide for greater indemnification of its officers and 
directors than is provided in the California Corporation Code. If we become subject to Section 2115(b), our ability to indemnify our officers and 
directors, to the extent permitted in our Articles of Incorporation, Bylaws and under Nevada law, may be limited by California law.  

Nevada law permits distributions to stockholders as long as, after the distribution, (i) the corporation would be able to pay its debts as they 
become due and (ii) the corporation’s total assets are at least equal to its liabilities and preferential dissolution obligations. Under California law, 
distributions may be made to stockholders as long as the corporation would be able to pay its debts as they mature and either (i) the corporation’s 
retained earnings equals or exceeds the amount of the proposed distributions, or (ii) after the distributions, the corporation’s tangible assets are at 
least 125% of its liabilities and the corporation’s current assets are at least equal to its current liabilities (or, 125% of its current liabilities if the 
corporation’s average operating income for the two most recently completed fiscal years was less than the average of the interest expense of the 
corporation for those fiscal years). If we become subject to Section 2115(b), we will have to satisfy more stringent financial requirements to be 
able to pay dividends to our stockholders. Additionally, stockholders may be liable to the corporation if we pay dividends in violation of 
California law.  

California law permits a corporation to provide “supermajority vote” provisions in its Articles of Incorporation, which would require 
specific actions to obtain greater than a majority of the votes, but not more than 66 2 / 3 percent. Nevada law does not permit supermajority vote 
provisions. If we become subject to Section 2115(b), it is possible that our stockholders would vote to amend our Articles of Incorporation and 
require a supermajority vote for us to take specific actions.  

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Under California law, in a disposition of substantially of all the corporation’s assets, if the acquiring party is in control of or under 
common control with the disposing corporation, the principal terms of the sale must be approved by 90 percent of the stockholders. Although 
Nevada law does contain certain rules governing interested stockholder business combinations, it does not require similar stockholder approval. 
If we become subject to Section 2115(b), we may have to obtain the vote of a greater percentage of the stockholders to approve a sale of our 
assets to a party that is in control of, or under common control with, us.  

California law places certain additional approval rights in connection with a merger if all of the shares of each class or series of a 

corporation are not treated equally or if the surviving or parent party to a merger represents more than 50 percent of the voting power of the other 
corporation prior to the merger. Nevada law does not require such approval. If we become subject to Section 2115(b), we may have to obtain a 
the vote of a greater percentage of the stockholders to approve a merger that treats shares of a class or series differently or where a surviving or 
parent party to the merger represents more than 50% of the voting power of the other corporation prior to the merger.  

California law requires the vote of each class to approve a reorganization or a conversion of a corporation into another entity. Nevada law 
does not require a separate vote for each class. If we become subject to Section 2115(b), we may have to obtain the approval of each class if we 
desire to reorganize or convert into another type of entity.  

California law provides greater dissenters’ rights to stockholders than Nevada law. If we become subject to Section 2115(b), more 

stockholders may be entitled to dissenters’ rights, which may limit our ability to merge with another entity or reorganize.  

Our stock is deemed to be penny stock.  

Our stock is currently traded on the OTCQB, operated by the OTC Markets Group, Inc., and is subject to the “penny stock rules” adopted 
pursuant to Section 15(g) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). The penny stock rules apply to companies 
not listed on a national exchange whose common stock trades at less than $5.00 per share or which have tangible net worth of less than 
$5,000,000 ($2,000,000 if the company has been operating for three or more years). Such rules require, among other things, that brokers who 
trade “penny stock” to persons other than “established customers” complete certain documentation, make suitability inquiries of investors and 
provide investors with certain information concerning trading in the security, including a risk disclosure document and quote information under 
certain circumstances. Penny stocks sold in violation of the applicable rules may entitle the buyer of the stock to rescind the sale and receive a 
full refund from the broker.  

Many brokers have decided not to trade “penny stock” because of the requirements of the penny stock rules and, as a result, the number of 
broker-dealers willing to act as market makers in such securities is limited. In the event that we remain subject to the “penny stock rules” for any 
significant period, there may develop an adverse impact on the market, if any, for our securities. Because our securities are subject to the “penny 
stock rules,” investors will find it more difficult to dispose of our securities. Further, for companies whose securities are traded in the OTC 
Bulletin Board, it is more difficult: (i) to obtain accurate quotations, (ii) to obtain coverage for significant news events because major wire 
services, such as the Dow Jones News Service, generally do not publish press releases about such companies, and (iii) to obtain needed capital.  

If we fail to maintain effective internal controls over financial reporting, the price of our common stock may be adversely affected.  

Our internal controls over financial reporting may have weaknesses and conditions that could require correction or remediation, the 
disclosure of which may have an adverse impact on the price of our common stock. We are required to establish and maintain appropriate 
internal controls over financial reporting. Failure to establish those controls (or any failure of those controls once established) could adversely 
impact our public disclosures regarding our business, financial condition or results of operations. In addition, management’s assessment of 
internal controls over financial reporting may identify weaknesses and conditions that need to be addressed in our internal controls over financial 
reporting or other matters that may raise concerns for investors. Any actual or perceived weaknesses and conditions that need to be addressed in 
our internal control over financial reporting and disclosure of management’s assessment of our internal controls over financial reporting may 
have an adverse impact on the price of our common stock.  

Standards for compliance with Section 404 of the Sarbanes-Oxley Act of 2002 are uncertain, and if we fail to comply in a timely manner, 
our business could be harmed and our stock price could decline.  

Rules adopted by the SEC pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 require an annual assessment of our internal 

controls over financial reporting. The standards that must be met for management to assess the internal controls over financial reporting as 
effective are evolving and complex, and require significant documentation, testing, and possible remediation to meet the detailed standards. We 
expect to continue to incur significant expenses and to devote resources to continued Section 404 compliance on an ongoing basis. It is difficult 
for us to predict how long it will take or how costly it will be to complete the assessment of the effectiveness of our internal controls over 
financial reporting and to remediate any deficiencies in our internal controls. As a result, we may not be able to complete the assessment and 
remediation process on a timely basis. In the event that our Chief Executive Officer or Chief Financial Officer determine that our internal 
controls over financial reporting are not effective as defined under Section 404, we cannot predict how regulators will react or how the market 
price of our common stock will be affected; however, we believe that there is a risk that investor confidence and share value may be negatively 
impacted.  

22 

   
   
   
   
   
   
   
   
   
   
   
   
  
If we fail to remain current in our reporting requirements, our securities could be removed from the OTC Bulletin Board, which would 
limit the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in the secondary market.  

Companies trading on the OTCQB must be reporting issuers under Section 12 of the Exchange Act, and must be current in their reports 

under Section 13, in order to maintain price quotation privileges on the OTC Bulletin Board. If we fail to remain current on our reporting 
requirements, we could be removed from the OTC Bulletin Board. As a result, the market liquidity for our securities could be severely adversely 
affected by limiting the ability of broker-dealers to sell our securities and the ability of stockholders to sell their securities in the secondary 
market.  

ITEM 1B.  UNRESOLVED STAFF COMMENTS 

Not applicable.  

ITEM 2. 

PROPERTIES 

We do not own real property. We currently lease two facilities, with approximately 12,000 square feet of corporate, research and 

development, and warehouse facilities, located in Lake Forest, California (“Lake Forest Facility”) and approximately 4,100 square feet of 
corporate offices located in San Diego, California (“San Diego Facility”). In June 2010, the Company entered into a third amendment to the 
Lake Forest Facility lease and extended the lease for sixty months commencing July 1, 2010 with a right to cancel the lease with a minimum of 
120 day written notice at any time after December 31, 2012. On November 28, 2011, the Company entered into a lease agreement for the 
corporate offices in San Diego for a thirty six month period ending December 31, 2014.  

The Company currently makes base lease payments of approximately $17,000 per month, due at the beginning of each month. We believe 
that these facilities are adequate, suitable and of sufficient capacity to support our immediate needs. Additional space may be required, however, 
as we expand our research and development, manufacturing and selling and marketing activities.  

ITEM 3. 

LEGAL PROCEEDINGS 

In the ordinary course of business, we are at times subject to various legal proceedings and disputes, including product liability claims. We 

currently are not aware of any such legal proceedings or claim that we believe will have, individually or in the aggregate, a material adverse 
effect on our business, operating results or cash flows. It is our practice to accrue for open claims based on our historical experience and 
available insurance coverage.  

ITEM 4.  MINE SAFETY DISCLOSURES 

Not applicable.  

23 

   
   
   
   
   
   
   
   
   
   
   
   
  
PART II  

ITEM 5.  MARKET  FOR  REGISTRANT’S  COMMON  EQUITY,  RELATED  STOCKHOLDERS’  MATTERS  AND  ISSUER 

PURCHASES OF EQUITY SECURITIES 

Market Information  

(a) Market Information. Presently, our common stock is quoted on the OTCQB, operated by the OTC Markets Group, Inc. under the 
symbol CYRX. On June 17, 2013, the last reported sale of our common stock was $0.24. The following table shows the high and low sales price 
of our common stock for the two fiscal years ended March 31, 2013 and 2012.  

Fiscal Year 2013 
Quarter Ended March 31, 2013 
Quarter Ended December 31, 2012 
Quarter Ended September 30, 2012 
Quarter Ended June 30, 2012 
Fiscal Year 2012 
Quarter Ended March 31, 2012 
Quarter Ended December 31, 2011 
Quarter Ended September 30, 2011 
Quarter Ended June 30, 2011 

Common Stock  
Sales Price 

High 

Low 

  $ 
  $ 
  $ 
  $ 

  $ 
  $ 
  $ 
  $ 

0.61     $ 
0.39     $ 
0.51     $ 
0.70     $ 

0.90     $ 
1.24     $ 
1.73     $ 
1.60     $ 

0.33   
0.11   
0.19   
0.37   

0.60   
0.65   
0.96   
0.85   

(b) Holders. As of June 17, 2013, the number of stockholders of record of the Company’s common stock was 146.  

(c) Dividends. No dividends on common stock have been declared or paid by the Company. The Company intends to employ all available 

funds for the development of its business and, accordingly, does not intend to pay any cash dividends in the foreseeable future.  

(d) Securities Authorized for Issuance Under Equity Compensation. The information included under Item 12 of Part III of this Annual 

Report is hereby incorporated by reference into this Item 5 of Part II of this Annual Report.  

(e) Recent Sale of Unregistered Securities . The following is a summary of transactions by the Company during period covered by this 
report involving the issuance and sale of the Company’s securities that were not registered under the Securities Act of 1933, as amended (the 
“Securities Act”) and that have not previously been included in a Quarterly Report on Form 10-Q or in a Current Report on Form 8-K. All 
securities sold by the Company were sold to individuals, trusts or others who were accredited investors as defined under Regulation D under the 
Securities Act, as amended.  

In the fourth quarter of fiscal 2013, the Company issued to certain accredited investors unsecured convertible promissory notes (the 
“Bridge Notes”) in the original principal amount of $1,294,500. The Bridge Notes accrue interest at a rate of 15% per annum from date of 
issuance until January 31, 2013 and at a rate of 5% per annum from February 1, 2013 through the date of payment, in each case on a non-
compounding basis. All principal and interest under the Bridge Notes will be due on December 31, 2013. In the event the Company designated 
and issued preferred stock while the Bridge Notes were outstanding, the Bridge Notes were convertible into shares of such preferred stock at a 
conversion rate equal to the price per share paid to the Company in connection with the issuance of such preferred stock at the option of the 
holder of the Bridge Notes.  

Effective on April 19, 2013, the Company amended the Bridge Notes whereby in the event that the Company issues one or more types of 
equity securities (a “Transaction”) before the maturity of the Bridge Notes, the holder may elect to convert all or a portion of the principal and 
accrued interest into shares of such equity securities issued in a Transaction at a conversion rate equal to the price per share paid to the Company 
in connection with the issuances. The Company is required to notify the holder of a Transaction within 10 days of each Transaction and the 
holder has the option until the later of (a) ten (10) days after such notices or (b) December 15, 2013 to elect in writing to convert.  

In April 2012, the Company issued a warrant to purchase 30,000 shares of the Company’s common stock at an exercise price of $0.50 per 

share to a consultant for services rendered to the Company.  

24 

   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
    
  
    
        
    
    
        
    
ITEM 6. 

SELECTED FINANCIAL DATA 

The following selected financial data has been derived from audited consolidated financial statements of the Company for each of the five 

years in the period ended March 31, 2013. These selected financial summaries should be read in conjunction with the financial information 
contained for each of the two years in the period ended March 31, 2013, included in the consolidated financial statements and notes thereto, 
Management’s Discussion and Analysis of Results of Operations and Financial Condition, and other information provided elsewhere herein.  

Years Ended March 31,  
(in thousands, except per share data)  

2013 

2012 

2011 

2010 

2009 

  $ 

1,101     $ 

556     $ 

476     $ 

118     $ 

35   

Consolidated Statement of Operations Data: 
Revenues 

Cost of revenues 
Gross loss 

Selling, general and administrative 
Research and development 
Total operating expenses 

Loss from operations 
Other (expense) income: 
Interest income 
Interest expense 
Loss on sale of fixed assets 
Loss on extinguishment of debt 
Change in fair value of derivative liabilities 

1,588       
(487 )     
5,412       
425       
5,837       
(6,324 )     

-      
(72 )     
—      
—      
16       
(6,380 )     
2       
(6,382 )   $ 
(0.17 )   $ 

1,392       
(836 )     
6,106       
492       
6,598       
(7,434 )     

12       
(528 )     
—      
—      
119       
(7,831 )     
2       
(7,833 )   $ 
(0.27 )   $ 

1,303       
(827 )     
4,321       
449       
4,770       
(5,597 )     

16       
(619 )     
—      
—      
50       
(6,150 )     
2       
(6,152 )   $ 
(0.46 )   $ 

718       
(600 )     
3,313       
284       
3,597       
(4,197 )     

8       
(7,029 )     
(9 )     
—      
5,577       
(5,650 )     
2       
(5,652 )   $ 
(1.13 )   $ 

546   
(511 ) 
2,387   
297   
2,684   
(3,195 ) 

32   
(2,693 ) 
—  
(10,847 ) 
—  
(16,703 ) 
2   
(16,705 ) 
(4.05 ) 

Net loss before income taxes 
Income taxes 
Net loss 
Net loss per common share, basic and diluted 
Weighted average shares used in computing net loss per common share, 

  $ 
  $ 

basic and diluted 

37,761       

28,975       

13,302       

5,011       

4,124   

Consolidated Balance Sheet Data: 
Cash, cash equivalents 
Working capital (deficit) 
Total assets 
Convertible notes and accrued interest, net 
Other long-term obligations 
Accumulated deficit 
Total stockholders’ equity (deficit) 

As of March 31,  
(in thousands)  

2013 

2012 

2011 

2010 

2009 

  $ 

563     $ 
(1,539 )     
1,756       
1,305       
1,322       
(66,311 )     
(2,063 )     

4,618     $ 
4,024       
6,214       
338       
1,375       
(59,929 )     
3,730       

9,278     $ 
6,760       
11,031       
2,401       
1,423       
(52,096 )     
5,948       

3,630     $ 
1,995       
4,777       
2,502       
1,478       
(45,944 )     
(915 )     

250   
(3,693 ) 
1,573   
3,883   
1,601   
(30,634 ) 
(4,776 ) 

25 

   
   
   
   
   
   
   
  
  
  
    
    
    
    
  
    
        
        
        
        
    
  
    
        
        
        
        
    
    
    
    
    
    
    
    
        
        
        
        
    
    
    
    
    
    
    
    
    
  
  
    
    
    
    
  
    
        
        
        
        
    
    
    
    
    
    
    
ITEM 7.  MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS 

This Annual Report on Form 10-K contains forward-looking statements that have been made pursuant to the provisions of the Private 

Securities Litigation Reform Act of 1995 and concern matters that involve risks and uncertainties that could cause actual results to differ 
materially from those projected in the forward-looking statements. Discussions containing forward-looking statements may be found in the 
material set forth under “Business,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and in other 
sections of this Form 10-K. Words such as “may,” “will,” “should,” “could,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” 
“potential,” “continue” or similar words are intended to identify forward-looking statements, although not all forward-looking statements contain 
these words. Although we believe that our opinions and expectations reflected in the forward-looking statements are reasonable as of the date of 
this Annual Report on Form 10-K, we cannot guarantee future results, levels of activity, performance or achievements, and our actual results 
may differ substantially from the views and expectations set forth in this Annual Report on Form 10-K. We expressly disclaim any intent or 
obligation to update any forward-looking statements after the date hereof to conform such statements to actual results or to changes in our 
opinions or expectations. Readers are urged to carefully review and consider the various disclosures made by us, which attempt to advise 
interested parties of the risks, uncertainties, and other factors that affect our business, set forth in detail in Item 1A of Part I, under the heading 
“Risk Factors.”  

The following discussion and analysis should be read in conjunction with our consolidated financial statements and the related notes to 

those statements contained elsewhere in this Annual Report on Form 10-K.  

General Overview  

We provide leading edge frozen shipping logistics solutions to the biotechnology and life science industries. Since 2008, through the 
combination of purpose-built proprietary hardware and software technologies and logistics knowhow known as “total turnkey management” we 
have provided total logistics management to the biotechnology and life sciences industries. Our solutions are disruptive to “old technologies” 
and provide reliable, economic alternatives to currently existing products and services utilized for frozen shipping in biotechnology and life 
sciences including stem cells, cell lines, vaccines, diagnostic materials, semen and embryos for in-vitro fertilization, cord blood, bio-
pharmaceuticals, infectious substances and other items that require continuous exposure to frozen or cryogenic temperatures. In addition, our 
solutions can contribute to the reliability, efficiency, and effectiveness of clinical trials.  

Cryoport Express ® Solutions include a cloud-based logistics management software branded as the Cryoportal TM . The Cryoportal 

supports the management of the entire shipment process through a single interface which includes initial order input, document preparation, 
customs clearance, courier management, shipment tracking, issue resolution, and delivery. Cryoport’s total turnkey logistics solutions offer 
reliability, cost effectiveness, and convenience, while the use of recyclable and reusable components provides “green”, environmentally friendly 
solutions. The Cryoportal provides an array of unique information dashboards and validation documentation for each and every shipment.  

Integral to our logistics solutions are the Cryoport Liquid Nitrogen Dry Vapor Shippers (Cryoport Express ® Shippers) which are cost-

effective and reusable cryogenic transport containers (patented vacuum flasks) utilizing innovative liquid nitrogen (LN2) “dry vapor” 
technology. Cryoport Express ® Shippers are non-hazardous, IATA (International Air Transport Association) certified, and validated to maintain 
stable temperatures below minus 150° Celsius for a 10-plus day dynamic shipment period. The Company currently features two Cryoport 
Express ® Shipper models, the Standard Dry Shipper (holding up to approximately 75-2.0 ml vials) and the High Volume Dry Shipper (holding 
up to approximately 500-2.0 ml vials).  

Cryoport Express ® Solutions include recording and retaining a fully documented “chain-of-custody” and, at the client’s option, “chain-of-
condition” for every shipment, helping ensure that quality, safety, efficacy, and stability of shipped commodities are maintained. This recorded 
and archived information allows our customers to meet the exacting requirements necessary for scientific work and for regulatory purposes. 
Cryoport Express ® Solutions can be used by customers, as a “turnkey” solution, through direct access to the cloud-based Cryoportal, or by 
contacting Cryoport client Care for order entry tasks. Cryoport provides 24/7/365 logistics services through its Client Care team and also 
provides complete training and process management services to support each client’s specific requirements.  

Since 2010, Cryoport Express ® Solutions have been the Company’s principal focus for development and commercialization. During fiscal 

year 2013, the Company approach to the market was adjusted to a solutions orientation and it expanded its service offering to address specific 
market needs in the biotechnology and life science industries. As a solutions provider, Cryoport tailors frozen logistics solutions to client 
requirements. In addition to custom solutions, the Company’s primary customer facing solutions offerings are as follows:  

•  Cryoport Express ® Solution 

The fully outsourced turnkey logistics solution described herein.  

•  Customer-Staged Solution 

Cryoport ships an inventory of Cryoport Express ® Shippers to the customer (uncharged and in bulk) enabling the customer to 
charge the shippers at their facility, process their orders through the Cryoportal which permits Cryoport Client Care to oversee 
the each shipment and the return the shippers to Cryoport for cleaning, testing and refurbishing. Cryoport Client Care provides 
the 24/7/365 logistics services utilizing its Cryoportal logistics platform.  

   
   
   
   
   
   
   
   
   
   
   
   
   
  
26 

   
•  Customer-Managed Solution 

Cryoport ships a fully charged Cryoport Express ® Shipper(s) to the customer enabling the customer to utilize its internal 
expertise to manage all or a portion of the logistics services. As with the above solutions, the shippers are returned to Cryoport 
for cleaning, testing and refurbishing within a pre-determined time period.  

•  Customer Integrated Logistics 

The Cryoport logistics team provides a tailored and full range of logistics support solutions. In addition to tailoring a 
management solution, the robust, enterprise grade Cryoportal is used to provide complete logistics services while enabling the 
customer to utilize their own packaging solutions or Cryoport Express ® Shippers. Cryoport can provide onsite logistics 
personnel allowing the customer to fully outsource their cold chain logistics needs to Cryoport and focus on its core 
competencies.  

•  Distribution Partnerships 

“Powered by Cryoport” is an important partnership arrangements with integrators, freight forwarders and other logistics 
providers, enabling partners to expand their solutions offering by adding the total Cryoport Express ® Shipper solution to their 
customer offering.  

We offer our solutions to companies in the biotechnology and life sciences industries and specific verticals including manufacturers of 

stem cells and cell lines, diagnostic laboratories, bio-pharmaceuticals, in-vitro fertilization, cord blood, vaccines, tissue, animal husbandry, and 
other producers of commodities requiring reliable frozen solutions for logistics problems.  

27 

   
   
   
   
   
   
   
   
  
These companies operate within heavily regulated environments and as such, changing vendors and distribution practices typically 

require a number of steps, which may include the audit of our facilities, review of our procedures, qualifying us as a vendor, and performing test 
shipments. This process can take up to nine to eighteen months or longer to complete prior to a potential customer adopting Cryoport Express ® 
Solutions.  

Going Concern  

As reported in the Report of Independent Registered Public Accounting Firm to our March 31, 2013 and 2012 consolidated financial 

statements, we have incurred recurring losses and negative cash flows from operations since inception. These factors, among others, raise 
substantial doubt about our ability to continue as a going concern.  

There are significant uncertainties, which may negatively affect our operations. These are principally related to (i) the expected ramp up of 
revenues of Cryoport Express ® Solutions, (ii) the lack of firm purchasing commitments from our customers due to the on-demand nature of our 
business, (iii) the success in bringing additional products to market in response to customer demands, and (iv) risks associated with scaling 
company operations to meet demand. Moreover, there is no assurance as to when, if ever, we will be able to conduct our operations on a 
profitable basis. Our limited historical revenues for our reusable product, limited revenues to date of our Cryoport Express ® Solutions and the 
lack of any purchase requirements in our existing distribution agreements, make it difficult to identify any trends in our business prospects.  

While we increased revenue year-over-year by 98% to $1.1 million for the fiscal year ended March 31, 2013, our revenue is still 

significantly lower than our operating expenses during the year and we have no assurance of the level of future revenues. We incurred a net loss 
of $6.4 million and used cash of $4.8 million in our operating activities during the year ended March 31, 2013. We had negative working capital 
of $1.5 million, and had cash and cash equivalents of $0.6 million at March 31, 2013.  

We currently fund our operations through short-term bridge financing (see Note 8 of the notes to the consolidated financial statements) and 
plan to raise additional funds through an equity offering to cover general working capital needs and sales and marketing initiatives to expand our 
customer base and increase sales. There is no assurance that funds can be secured or if these funds would allow us to continue our operations 
until more significant revenues can be generated or more funding can be secured. These matters raise substantial doubt about our ability to 
continue as a going concern.  

Results of Operations  

The following table sets forth, for the periods indicated, certain information derived from our consolidated statements of operations.  

Revenues 
Cost of revenues 
Gross loss 
Operating expenses: 
Selling, general and administrative 
Research and development 
Total operating expenses 
Loss from operations 
Other income (expense): 
Interest income 
Interest expense 
Change in fair value of derivative liabilities 
Total other expense, net 
Loss before income taxes 
Income taxes 
Net loss 
Net loss available to common stockholders per common share: 
Basic and diluted loss per common share 

28 

2013  
(‘000) 

2012  
(‘000) 

1,101     $ 
1,588       
(487 )     

5,412       
425       
5,837       
(6,324 )     

-      
(72 )     
16       
(56 )     
(6,380 )     
2       
(6,382 )   $ 

556   
1,392   
(836 ) 

6,106   
492   
6,598   
(7,434 ) 

12   
(528 ) 
119   
(397 ) 
(7,831 ) 
2   
(7,833 ) 

(0.17 )   $ 

(0.27 ) 

  $ 

  $ 

  $ 

   
   
   
   
   
   
   
   
   
   
  
  
  
    
  
    
    
    
        
    
    
    
    
    
    
        
    
    
    
    
    
    
    
    
        
    
Weighted average common shares outstanding: 
Basic and diluted 

Years ended March 31, 2013 and 2012:  

2013  
(‘000) 

2012  
(‘000) 

37,761       

28,975   

Revenues . Revenues were $1,100,539 for the year ended March 31, 2013, as compared to $555,637 for the year ended March 31, 2012. 
The $544,902 or 98.1% increase is primarily driven by an increase in the number of customers utilizing our services as well as an increase in 
volume of certain customers compared to the prior year. We generated revenues from customers in all of our target life sciences markets, such as 
biotech and diagnostic companies, pharmaceutical companies, central laboratories, contract research organizations, the reproductive medicine 
market/in vitro fertilization market, and research institutions. Five customers generated in excess of $50,000 in revenues during fiscal 2013 
compared to only two customers in the prior year. The number of customers that shipped multiple times during the year more than doubled, 
compared the prior year. The increase in revenues is partially the result of positive responses to targeted telemarketing activities and email 
marketing campaigns to the in-vitro-fertilization/reproductive medicine market to broaden the awareness of our solution in this space. In 
addition, the increase in revenues was also due, in part, to the commencement of the implementation of our first customer integrated solution in 
February of 2013, whereby we were engaged to manage shipments of a specific vaccine from the manufacturing site in the United States to both, 
domestic customers and international distribution centers.  

Gross loss and cost of revenues . Gross loss for the year ended March 31, 2013 was 44% of revenues, or $487,284, as compared to 151% 

of revenues, or $836,823, for the prior year. Cost of revenues for the year ended March 31, 2013 was 144% of revenues, or $1,587,823 as 
compared to 251% of revenues, or $1,392,460, for the prior year. Our cost of revenues are primarily comprised of freight charges, payroll and 
related expenses related to our operations center in California, third-party charges for our European and Asian operations centers in Holland and 
Singapore, depreciation expenses of our Cryoport Express® Shippers and supplies and consumables used for our solutions. The increase in cost 
of revenues is primarily due to freight charges from the growth in shipments. The cost of revenues exceeded revenues due to fixed costs and 
plant underutilization.  

Selling, general and administrative expenses . Selling, general and administrative expenses were $5,411,728 for the year ended March 31, 
2013, as compared to $6,106,006 for the prior year. The $694,278 decrease reflects the decrease in consulting expenses, headcount, in particular 
a temporary decrease in the sales and marketing department due to the replacement of certain sales representatives, and the resignation of our 
Chief Executive Officer in April 2012, who was not replaced until November 2012, partly offset by stock-based compensation expenses for 
stock option grants issued to three members of the Company’s board of directors as compensation for their services as members of the Office of 
the Chief Executive Officer during that interim period.  

Research and development expenses . Research and development expenses were $425,446 for the year ended March 31, 2013, as 

compared to $491,849 for the prior year. Our research and development efforts are focused on continually improving the features of the Cryoport 
Express ® Solution, with the primary focus on further expanding the capabilities of our cloud-based logistics management platform, the 
Cryoportal TM . We use an outside software development company to provide these services.  

Interest expense . Interest expense was $72,861 for the year ended March 31, 2013, as compared to $527,753 for the prior year. Interest 

expense for the year ended March 31, 2013 included, stated interest expense on the convertible debt of $13,018, amortization of the debt 
discount and deferred financing costs of $17,514, and accrued interest on our related party notes payable of $42,216. Interest expense for the 
prior 2012 included the value on warrants issued to convertible debt holders of $156,999, stated interest expense on the convertible debt of 
$122,824, amortization of the debt discount of $197,225, and accrued interest on our related party notes payable of $48,036.  

Interest income . Interest income was zero for the year ended March 31, 2013 as compared to $11,940 for the prior year.  

Change in fair value of derivative liabilities . The gain on the change in fair value of derivative liabilities was $16,486 for the year ended 
March 31, 2013, compared to a gain of $119,163 for the prior year. The gain for the year ended March 31, 2013 was the result of a decrease in 
the value of our warrant derivatives, due primarily to a decrease in our stock price.  

Net loss . As a result of the factors described above, net loss for the year ended March 31, 2013 decreased by $1,450,495 to $6,382,433 or 
($0.17) per share compared to a net loss of $7,832,928 or ($0.27) per share for the prior year. The decrease of net loss per share compared to the 
prior year is a result of the decrease in the net loss as described above and the increase in the weighted average common shares outstanding from 
29.0 million to 37.8 million. This increase is primarily due to common stock issued in connection with the Company’s private placements late in 
fiscal 2012.  

Liquidity and Capital Resources  

As of March 31, 2013, the Company had cash and cash equivalents of $563,104 and negative working capital of $1,539,103. As of 
March 31, 2012, the Company had cash and cash equivalents of $4,617,535 and working capital of $4,024,120. Historically, we have financed 
our operations primarily through sales of our debt and equity securities. From March 2005 through March 2013, we have received net proceeds 
of approximately $34.1 million from sales of our common stock and the issuance of promissory notes, warrants and debt.  

   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
    
  
    
        
    
    
29 

   
For the year ended March 31, 2013, we used $4,785,144 of cash for operations primarily as a result of the net loss of $6,382,433 including 

non-cash expenses of $693,180 for the fair value of stock options and warrants. Net operating losses decreased as a result of a decrease in 
headcount. Offsetting the cash impact of our net operating loss (excluding non-cash items) was an increase in accounts payable and accrued 
expenses of $443,562. Net cash used in operating activities also was offset by $2,525 for other working capital uses.  

Net cash used in investing activities totaled $178,682 during the year ended March 31, 2013, and was attributable to the purchase of 

property and equipment of $156,200 and the purchase of intangible assets of $22,482.  

Net cash provided by financing activities totaled $909,395 during the year ended March 31, 2013, and resulted primarily from net 
proceeds received from issuance of convertible debt during the fourth quarter of fiscal 2013 in the amount of $1,294,500. This was partially 
offset by the payment of financing costs of $206,305, repayment of related party notes of $96,000 and repayment of convertible debt of $82,800. 

As discussed in Note 1 of the accompanying consolidated financial statements, there exists substantial doubt regarding the Company’s 
ability to continue as a going concern. As discussed above, the Company completed a private placement in March of 2012 and received proceeds 
from issuance of convertible debt as bridge financing in the fourth quarter of fiscal 2013. The funds raised are being used for working capital 
purposes and to continue our sales efforts to advance the Company’s commercialization of the Cryoport Express ® Solutions. As discussed in 
Note 16 of the accompanying audited consolidated financial statements, the Company issued additional unsecured convertible promissory notes 
in principal amount of $608,751 in the first quarter of fiscal 2014. However, the Company’s management recognizes that the Company will need 
to obtain additional capital to fund its operations and until sustained profitable operations are achieved. Management is currently working on 
such funding alternatives in order to secure sufficient operating capital through the end of fiscal year 2014. In addition, management will 
continue to review its operations for further cost reductions to extend the time that the Company can operate with its current cash on hand and 
additional bridge financing and to utilize third parties for services such as its international recycling and refurbishment centers to provide for 
greater flexibility in aligning operational expenses with the changes in sales volumes.  

Additional funding plans may include obtaining additional capital through equity and/or debt funding sources; however, no assurance can 

be given that additional capital, if needed, will be available when required or upon terms acceptable to the Company.  

Contractual Obligations  

The following table summarizes our contractual obligations as of March 31, 2013, and the effects such obligations are expected to have on 

liquidity and cash flow in future periods (in thousands):  

Operating Lease Obligations 
Bridge Notes 
Other Long-term Debt Obligations 
Total 

Payments Due by Period 

Total  

Less than 1  
Year  

1-3 Years       

3-5 Years       

More than  
5 Years  

  $ 

  $ 

433     $ 
1,305       
1,418       
3,156     $ 

213     $ 
1,305       
96       
1,614     $ 

220     $ 
—      
1,322       
1,542     $ 

—    $ 
—      
—      
—    $ 

—  
—  
—  
—  

Impact of Inflation . From time to time, Cryoport experiences price increases from third party manufacturers and these increases cannot 

always be passed on to Cryoport’s customers. While these price increases have not had a material impact on CryoPort’s historical operations or 
profitability in the past, they could affect revenues in the future.  

Critical Accounting Policies and Estimates  

Management’s discussion and analysis of financial condition and results of operations, as well as disclosures included elsewhere in this 

Annual Report, are based upon our consolidated financial statements, which have been prepared in accordance with U.S. generally accepted 
accounting principles. Our significant accounting policies are described in the notes to the audited consolidated financial statements contained 
elsewhere in this Annual Report. Included within these policies are our “critical accounting policies.” Critical accounting policies are those 
policies that are most important to the preparation of our consolidated financial statements and require management’s most subjective and 
complex judgment due to the need to make estimates about matters that are inherently uncertain. Although we believe that our estimates and 
assumptions are reasonable, actual results may differ significantly from these estimates. Changes in estimates and assumptions based upon actual 
results may have a material impact on our results of operations and/or financial condition.  

30 

    
   
    
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
    
    
  
    
    
We believe that the critical accounting policies that most impact the consolidated financial statements are as described below.  

Revenue Recognition  

Per Use Revenues  

We provide shipping containers to our customers and charge a fee in exchange for the use of the container. Our arrangements are similar to 

the accounting standard for leases since we convey the right to use the containers over a period of time. We retain title to the containers and 
provide our customers the use of the container for a specified shipping cycle. At the culmination of the customer’s shipping cycle, the container 
is returned to us.  

We recognize revenue for the use of the shipper at the time of the delivery of the shipper to the end user of the enclosed materials, and at 

the time that collectability is reasonably certain. Revenue is based on gross net of discounts and allowances.  

We also provide logistics support and management to some customers, which may include onsite logistics personnel. Revenue is 

recognized for these services as services are rendered and at the time that collectability is reasonably certain.  

Inventory  

The Company writes down its inventories for estimated obsolescence or unmarketable inventory equal to the difference between the cost 

of inventory and the estimated market value based upon assumptions about future demand, future pricing and market conditions. Inventory 
reserve costs are subject to estimates made by the Company based on historical experience, inventory quantities, age of inventory and any known 
expectations for product changes. If actual future demands, future pricing or market conditions are less favorable than those projected by 
management, additional inventory write-downs may be required and the differences could be material. Such differences might significantly 
impact cash flows from operating activities. Once established, write-downs are considered permanent adjustments to the cost basis of the 
obsolete or unmarketable inventories.  

Our business plan focuses on per-use leasing of the shipping container and value-added services that will be used by us to provide an end-

to-end and cost-optimized shipping solution. We provide shipping containers to our customers and charge a fee in exchange for the use of the 
container. Our arrangements are similar to the accounting standard for leases since we convey the right to use the containers over a period of 
time. We retain title to the containers and provide our customers the use of the container for a specified shipping cycle. At the culmination of the 
customer’s shipping cycle, the container is returned to us. The Company’s current inventory consists of accessories that are sold and shipped to 
customers along with loaned containers and not returned to the Company with the containers at the culmination of the customer’s shipping cycle. 

Property and Equipment  

Property and equipment are stated at cost, net of accumulated depreciation and amortization. Depreciation and amortization of fixed assets 

are provided using the straight-line method over the following useful lives:  

Cryoport Express ® Shippers 
Furniture and fixtures 
Machinery and equipment 
Leasehold improvements 

3 years 
7 years 
5-7 years 
Lesser of lease term or estimated useful life 

Betterments, renewals and extraordinary repairs that extend the lives of the assets are capitalized; other repairs and maintenance charges 

are expensed as incurred. The cost and related accumulated depreciation and amortization applicable to assets retired are removed from the 
accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets comprise patents and trademarks and software development costs. The Company capitalizes costs of obtaining patents 

and trademarks which are amortized, using the straight-line method over their estimated useful life of five years. The Company capitalizes 
certain costs related to software developed for internal use. Software development costs incurred during the preliminary or maintenance project 
stages are expensed as incurred, while costs incurred during the application development stage are capitalized and amortized using the straight-
line method over the estimated useful life of the software, which is five years. Capitalized costs include purchased materials and costs of services 
including the valuation of warrants issued to consultants.  

31 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
Long-Lived Assets  

The Company assesses the recoverability of its long-lived assets by determining whether the depreciation and amortization of long-lived 

assets over their remaining lives can be recovered through projected undiscounted cash flows. The amount of long-lived asset impairment is 
measured based on fair value and is charged to operations in the period in which long-lived asset impairment is determined by management. 
Manufacturing fixed assets are subject to obsolescence potential as result of changes in customer demands, manufacturing process changes and 
changes in materials used. The Company is not currently aware of any such changes that would cause impairment to the value of its 
manufacturing fixed assets.  

Stock-based Compensation  

We recognize compensation costs for all stock-based awards made to employees and directors. The fair value of stock-based awards is 

estimated at grant date using an option pricing model and the portion that is ultimately expected to vest is recognized as compensation cost over 
the requisite service period.  

We use the Black-Scholes option-pricing model to estimate the fair value of stock-based awards. The determination of fair value using the 

Black-Scholes option-pricing model is affected by our stock price as well as assumptions regarding a number of complex and subjective 
variables, including expected stock price volatility, risk-free interest rate, expected dividends and projected employee stock option exercise 
behaviors. We estimate the expected term based on the contractual term of the awards and employees’ exercise and expected post-vesting 
termination behavior.  

Derivative Liabilities  

Our issued and outstanding common stock purchase warrants previously treated as equity pursuant to the derivative treatment exemption 
were no longer afforded equity treatment, and the fair value of these common stock purchase warrants, some of which have exercise price reset 
features and some that were issued with convertible debt, was reclassified from equity to liability status as if these warrants were treated as a 
derivative liability since their date of issue. The common stock purchase warrants were not issued with the intent of effectively hedging any 
future cash flow, fair value of any asset, liability or any net investment in a foreign operation. The warrants do not qualify for hedge accounting, 
and as such, all future changes in the fair value of these warrants will be recognized currently in earnings until such time as the warrants are 
exercised or expire. These common stock purchase warrants do not trade in an active securities market, and as such, we estimate the fair value of 
these warrants using the Black-Scholes option pricing model.  

Convertible Debentures  

If a conversion feature of conventional convertible debt is not accounted for as a derivative instrument and provides for a rate of 

conversion that is below market value, this feature is characterized as a beneficial conversion feature (“BCF”). A BCF is recorded by the 
Company as a debt discount. In those circumstances, the convertible debt will be recorded net of the discount related to the BCF. The Company 
amortizes the discount to interest expense over the life of the debt using the effective interest method.  

Deferred Financing Costs  

Deferred financing costs represent costs incurred in connection with the issuance of the convertible notes payable and private equity 
financing. Deferred financing costs are being amortized over the term of the financing instrument on a straight-line basis, which approximates 
the effective interest method or netted against the gross proceeds received from equity financing.  

Income Taxes  

We account for income taxes under the provision of the Financial Accounting Standards Board (“FASB”) Accounting Standards 

Codification (“ASC”) 740, Income Taxes , or ASC 740. As of March 31, 2013 and 2012, there were no unrecognized tax benefits included in the 
accompanying balance sheets that would, if recognized, affect the effective tax rates. Based on the weight of available evidence, the Company’s 
management has determined that it is more likely than not that the net deferred tax assets will not be realized. Therefore, the Company has 
recorded a full valuation allowance against the net deferred tax assets. The Company’s income tax provision consists of state minimum taxes.  

Our practice is to recognize interest and/or penalties related to income tax matters in income tax expense. We had no accrual for interest or 

penalties on our consolidated balance sheets at March 31, 2013 and 2012, respectively and have not recognized interest and/or penalties in the 
consolidated statement of operations for the year ended March 31, 2013. We are subject to taxation in the United States and various state 
jurisdictions. As of March 31, 2013, the Company is no longer subject to U.S. federal examinations for years before 2009 and for California 
franchise and income tax examinations before 2008. However, to the extent allowed by law, the taxing authorities may have the right to examine 
prior periods where net operating losses were generated and carried forward, and make adjustments up to the amount of the net operating loss 
carry forward amount. The Company is not currently under examination by U.S. federal or state jurisdictions.  

32 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
ITEM 7A.       QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK  

Changes in United States interest rates would affect the interest earned on our cash and cash equivalents and interest expense on our 

revolving credit facility.  

Based on our overall cash and cash equivalents interest rate exposure at March 31, 2013, a near-term change in interest rates, based on 

historical movements, would not have a material adverse effect on our financial position or results of operations.  

We have operated primarily in the United States. Accordingly, we have not had any significant exposure to foreign currency rate 

fluctuations.  

ITEM 8.        FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA  

Reference is made to the consolidated financial statements included in this Report at pages F-3 through F-31.  

ITEM 9.        CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL 

DISCLOSURES  

None.  

ITEM 9A.        CONTROLS AND PROCEDURES  

(a) Evaluation of Disclosure Controls and Procedures. The term “disclosure controls and procedures” (defined in Rule 13a-15(e) under 

the Securities and Exchange Act of 1934 (the “Exchange Act”) refers to the controls and other procedures of a company that are designed to 
ensure that information required to be disclosed by a company in the reports that it files under the Exchange Act is recorded, processed, 
summarized and reported within the required time periods. Under the supervision and with the participation of our management, including our 
Chief Executive Officer and Chief Financial Officer, we have conducted an evaluation of the effectiveness of the design and operation of our 
disclosure controls and procedures, as of March 31, 2013. Based on this evaluation, our Chief Executive Officer and Chief Financial Officer 
concluded that our disclosure controls and procedures were effective as of March 31, 2013 to ensure the timely disclosure of required 
information in our Securities and Exchange Commission filings.  

Because of inherent limitations, internal control over financial reporting may not prevent or detect misstatements. In addition, the design of 
any system of control is based upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will 
succeed in achieving its stated goals under all future events, no matter how remote. Accordingly, even effective internal control over financial 
reporting can only provide reasonable assurance of achieving their control objectives.  

(b) Management’s Report on Internal Control Over Financial Reporting. Management’s Report on Internal Control Over Financial 

Reporting which appears on the following page is incorporated herein by this reference.  

(c) Changes in Internal Control over Financial Reporting. There have been no changes in our internal control over financial reporting 

during the fourth quarter of the fiscal year ended March 31, 2013 that have materially affected, or are reasonably likely to materially affect, our 
internal control over financial reporting.  

ITEM 9B.        OTHER INFORMATION  

None.  

CRYOPORT, INC.  
MANAGEMENT’S REPORT ON  
INTERNAL CONTROL OVER FINANCIAL REPORTING  

The management of the Company is responsible for establishing and maintaining effective internal control over financial reporting and for 

the assessment of the effectiveness of internal control over financial reporting. The Company’s internal control over financial reporting is a 
process designed, as defined in Rule 13a-15(f) under the Securities and Exchange Act of 1934, to provide reasonable assurance regarding the 
reliability of financial reporting and the preparation of consolidated financial statements for external purposes in accordance with generally 
accepted accounting principles.  

The Company’s internal control over financial reporting is supported by written policies and procedures that:  

• 

pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the 
Company’s assets; 

33 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
     
   
   
   
   
  
• 

• 

provide reasonable assurance that transactions are recorded as necessary to permit preparation of consolidated financial statements in 
accordance with generally accepted accounting principles, and that receipts and expenditures of the Company are being made only 
in accordance with authorizations of the Company’s management and directors; and 

provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the 
Company’s assets that could have a material effect on the consolidated financial statements. 

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any 

evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that 
the degree of compliance with the policies or procedures may deteriorate.  

In connection with the preparation of the Company’s annual consolidated financial statements, management of the Company has 

undertaken an assessment of the effectiveness of the Company’s internal control over financial reporting based on criteria established in Internal 
Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (“the COSO 
Framework”). Management’s assessment included an evaluation of the design of the Company’s internal control over financial reporting and 
testing of the operational effectiveness of the Company’s internal control over financial reporting.  

Based on this assessment, management has concluded that the Company’s internal control over financial reporting was effective as of 

March 31, 2013.  

By: 

By: 

/s/ JERRELL W. SHELTON  
Jerrell W. Shelton, 
Chief Executive Officer and Director 

/s/ ROBERT STEFANOVICH  
Robert Stefanovich, 
Chief Financial Officer 

June 25, 2013  

34 

   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
ITEM 10.        DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE  

PART III  

The information required by this Item regarding our directors, executive officers and committees of our board of directors is incorporated 

by reference to the information set forth under the captions “Election of Directors” and “Executive Compensation and Related Matters” in our 
2013 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 2013 (the “2013 Definitive Proxy 
Statement”).  

Information required by this Item regarding Section 16(a) reporting compliance is incorporated by reference to the information set forth 

under the caption “Section 16(a) Beneficial Ownership Reporting Compliance” in our 2013 Definitive Proxy Statement.  

Information required by this Item regarding our code of ethics is incorporated by reference to the information set forth under the caption 

“Corporate Governance” in Part I of this Annual Report on Form 10-K.  

ITEM 11.        EXECUTIVE COMPENSATION  

The information required by this Item is incorporated by reference to the information set forth under the caption “Executive Compensation 
and Related Matters” in our 2013 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended March 31, 2013.  

ITEM 12.       SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED 

STOCKHOLDER MATTERS  

The information required by this Item is incorporated by reference to the information set forth under the caption “Security Ownership of 
Directors and Executive Officers and Certain Beneficial Owners” in our 2013 Definitive Proxy Statement to be filed within 120 days after the 
end of our fiscal year ended March 31, 2013.  

ITEM 13.        CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE  

The information required by this Item is incorporated by reference to the information set forth under the captions “Certain Relationships 

and Related Transactions” and “Compensation Committee Interlocks and Insider Participation” in our 2013 Definitive Proxy Statement to be 
filed within 120 days after the end of our fiscal year ended March 31, 2013.  

ITEM 14.        PRINCIPAL ACCOUNTANT FEES AND SERVICES  

The information required by this Item is incorporated by reference to the information set forth under the caption “Independent Registered 

Public Accounting Firm Fees” in our 2013 Definitive Proxy Statement to be filed within 120 days after the end of our fiscal year ended 
March 31, 2013.  

35 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
ITEM  15: Exhibits and Financial Statement Schedules.  

(a) Financial Statements  

(1) Index to Consolidated Financial Statements  

PART IV  

The financial statements required by this item are submitted in a separate section beginning on page F-1 of this report.  

Report of Independent Registered Public Accounting Firm 
Consolidated Balance Sheets at March 31, 2013 and 2012 
Consolidated Statements of Operations the years ended March 31, 2013 and 2012 
Consolidated Statements of Stockholders’ (Deficit) Equity for the years ended March 31, 2013 and 2012 
Consolidated Statements of Cash Flows for the years ended March 31, 2013 and 2012 
Notes to Consolidated Financial Statements 

2. 

Financial Statement Schedules 

F-2 
F-3 
F-4 
F-5 
F-6 
F-7 

All financial statement schedules are omitted because they were not required or the required information is included in the Consolidated 
Financial Statements and the related Notes thereto.  

3. 

Exhibit Index 

See Exhibit Index  

36 

   
   
   
   
   
   
   
   
   
   
   
  
CRYOPORT, INC.  
INDEX TO CONSOLIDATED FINANCIAL STATEMENTS  

Report of Independent Registered Public Accounting Firm 
Consolidated Balance Sheets as of March 31, 2013 and 2012 
Consolidated Statements of Operations for the years ended March 31, 2013 and 2012 
Consolidated Statements of Stockholders’ (Deficit) Equity for the years ended March 31, 2013 and 2012 
Consolidated Statements of Cash Flows for the years ended March 31, 2013 and 2012 
Notes to Consolidated Financial Statements 

37 

Page 
F-2 
F-3 
F-4 
F-5 
F-6 
F-7 

     
   
   
  
  
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

To the Board of Directors of  
CryoPort, Inc.  

We have audited the accompanying consolidated balance sheets of CryoPort, Inc. (the “Company”) as of March 31, 2013 and 2012, and the 
related consolidated statements of operations, stockholders’ (deficit) equity and cash flows for the years then ended. These consolidated financial 
statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these consolidated financial 
statements based on our audits.  

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards 
require that we plan and perform the audits to obtain reasonable assurance about whether the consolidated financial statements are free of 
material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the consolidated 
financial statements. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial 
reporting. Our audits included consideration of internal control over financial reporting as a basis for designing audit procedures that are 
appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over 
financial reporting. Accordingly, we express no such opinion. An audit also includes assessing the accounting principles used and significant 
estimates made by management, as well as evaluating the overall consolidated financial statement presentation. We believe that our audits 
provide a reasonable basis for our opinion.  

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial position 
of CryoPort, Inc. at March 31, 2013 and 2012, and the results of its operations and its cash flows for the years then ended in conformity with 
accounting principles generally accepted in the United States of America.  

The accompanying consolidated financial statements have been prepared assuming the Company will continue as a going concern. As described 
in Note 1 to the consolidated financial statements, the Company has incurred recurring operating losses and has had negative cash flows from 
operations since inception. Although the Company has cash and cash equivalents of $563,104 at March 31, 2013, management has estimated that 
cash on hand, which include proceeds from convertible bridge notes received in the fourth quarter of fiscal 2013, will only be sufficient to allow 
the Company to continue its operations into the second quarter of fiscal 2014. These matters raise substantial doubt about the Company’s ability 
to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The consolidated financial 
statements do not include any adjustments to reflect possible future effects on the recoverability and classification of assets or the amount and 
classification of liabilities that may result from the outcome of this uncertainty.  

/s/ KMJ Corbin & Company LLP  

Costa Mesa, California  
June 25, 2013  

F- 2 

    
   
   
   
   
   
   
   
   
  
CRYOPORT, INC.  

CONSOLIDATED BALANCE SHEETS  

Current assets: 

ASSETS 

Cash and cash equivalents 
Restricted cash 
Accounts receivable, net of allowances of $8,700 in 2013 and $5,500 in 2012 
Inventories 
Other current assets 

Total current assets 

Property and equipment, net 
Intangible assets, net 
Deposits and other assets 
Total assets 

Current liabilities: 

LIABILITIES AND STOCKHOLDERS’ (DEFICIT) EQUITY 

Accounts payable and accrued expenses 
Accrued compensation and related expenses 
Convertible debentures payable and accrued interest, net of discount of $8,843 in 2012 
Current portion of related party notes payable 
Derivative liabilities 

Total current liabilities 

Related party notes payable and accrued interest, net of current portion 

Total liabilities 

Commitments and contingencies 
Stockholders’ (deficit) equity: 

Preferred stock, $0.001 par value, 2,500,000 shares authorized, none issued and  

outstanding 

Common stock, $0.001 par value; 250,000,000 shares authorized; 37,760,628  shares issued and 

outstanding at March 31, 2013 and 2012 

Additional paid-in capital 
Accumulated deficit 

Total stockholders’ (deficit) equity 

Total liabilities and stockholders’ (deficit) equity 

See accompanying notes to consolidated financial statements.  

F- 3 

  $ 

  $ 

  $ 

March 31, 

2013 

2012 

563,104     $ 
-      
217,097       
39,212       
138,892       
958,305       
505,485       
272,263       
19,744       
1,755,797     $ 

858,709     $ 
217,432       
1,304,419       
96,000       
20,848       
2,497,408       
1,321,664       

4,617,535   
251,368   
146,124   
51,754   
65,970   
5,132,751   
682,021   
379,083   
19,744   
6,213,599   

401,399   
235,996   
337,902   
96,000   
37,334   
1,108,631   
1,375,448   

3,819,072       

2,484,079   

—      

—  

37,761       
64,210,412       
(66,311,448 )     
(2,063,275 )     
1,755,797     $ 

37,761   
63,620,774   
(59,929,015 ) 
3,729,520   
6,213,599   

  $ 

    
   
   
   
   
  
  
  
  
  
  
    
  
    
        
    
    
        
    
    
    
    
    
    
    
    
    
    
        
    
    
        
    
    
    
    
    
    
    
  
  
  
    
  
  
    
    
    
        
    
    
        
    
    
    
    
    
    
CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF OPERATIONS  

Revenues 
Cost of revenues 
Gross loss 
Operating expenses: 

Selling, general and administrative 
Research and development 
Total operating expenses 

Loss from operations 
Other (expense) income: 

Interest income 
Interest expense 
Change in fair value of derivative liabilities 
Total other expense, net 

Loss before provision for income taxes 
Provision for income taxes 
Net loss 
Net loss per common share, basic and diluted 
Basic and diluted weighted average common shares outstanding 

  $ 

Years Ended March 31, 
2013 
2012 
1,100,539     $ 
1,587,823       
(487,284 )     

555,637   
1,392,460   
(836,823 ) 

5,411,728       
425,446       
5,837,174       

6,106,006   
491,849   
6,597,855   

(6,324,458 )     

(7,434,678 ) 

-      
(72,861 )     
16,486       
(56,375 )     
(6,380,833 )     
1,600       
(6,382,433 )   $ 
(0.17 )   $ 
37,760,628       

11,940   
(527,753 ) 
119,163   
(396,650 ) 
(7,831,328 ) 
1,600   
(7,832,928 ) 
(0.27 ) 
28,974,843   

  $ 
  $ 

See accompanying notes to consolidated financial statements.  

F- 4 

    
   
   
   
   
  
  
  
  
  
  
    
  
    
    
    
        
    
    
    
    
  
  
  
    
  
  
    
    
    
        
    
    
    
    
    
    
    
    
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ (DEFICIT) EQUITY  

CRYOPORT, INC.  

Preferred Stock 

Common Stock 

Shares 

Amount 

Balance at April 1, 2011 
Exercise of warrants for cash 
Cashless exercise of warrants 
Offering costs in connection with the February 2011 private 

placement offering 

Estimated fair value of common stock warrants issued to 

convertible debenture holders 

Issuance of units in private placement offering, net of offering 

costs of $572,255 

Stock-based compensation related to stock options and 
warrants issued to consultants, employees and  
directors 

Net loss 
Balance at March 31, 2012 
Offering costs in connection with the February 2012 private 

placement offering 

Stock-based compensation related to stock options and 
warrants issued to consultants, employees and  
directors 

Net loss 
Balance at March 31, 2013 

—      $ 
—        
—        

—        

—        

—        

—        
—        
—        

—        

—        
—        
—      $ 

Shares 
27,504,604       $ 
742,380         
36,090         

Amount 

27,505       $ 
742         
36         

Total 

Additional 
Paid-in 
Capital 
58,016,991       $ 
570,888         
(36 )       

      Accumulated        Stockholders’    
      (Defict) Equity   
5,948,409   
571,630   
—  

Deficit 
(52,096,087 )     $ 
—        
—        

—        

—        

—        

(36,543 )       

—        

(36,543 ) 

—        

156,999         

—        

156,999   

—        
—        
—        

—        

—        

—        

9,477,554         

9,478         

4,630,922         

—        

4,640,400   

—        
—        
—        

—        

—        
—        
37,760,628         

—        
—        
37,761         

281,553         
—        
63,620,774         

—        
(7,832,928 )       
(59,929,015 )       

281,553   
(7,832,928 ) 
3,729,520   

—        

—        

(103,542 )       

—        

(103,542 ) 

—        
—        
—        

—        
—        
37,760,628       $ 

—        
—        
37,761       $ 

693,180         
—        
64,210,412       $ 

—        
(6,382,433 )       
(66,311,448 )     $ 

693,180   
(6,382,433 ) 
(2,063,275 ) 

See accompanying notes to consolidated financial statements.   

F- 5 

    
   
    
   
   
  
  
  
     
     
     
  
     
  
  
  
  
     
  
     
  
     
  
     
  
  
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
CRYOPORT, INC.  

CONSOLIDATED STATEMENTS OF CASH FLOWS  

Years Ended March 31,  

2013  

2012  

  $ 

(6,382,433 )   $ 

(7,832,928 ) 

OPERATING ACTIVITIES 

Net loss 
Adjustments to reconcile net loss to net cash used in operating activities: 

Depreciation and amortization 
Amortization of debt discount and deferred financing costs 
Fair value of warrants issued to convertible debenture holders 
Fair value of stock options and warrants issued to consultants, employees 

and directors 

Change in fair value of derivative instruments 
Loss on write-off of intangible assets 
Loss on disposal of cryogenic shippers 
Interest accrued on restricted cash 
Changes in operating assets and liabilities: 

Accounts receivable 
Inventories 
Other assets 
Accounts payable and accrued expenses 
Accrued compensation and related expenses 
Accrued interest 

Net cash used in operating activities 

INVESTING ACTIVITIES 

Purchases of intangible assets 
Purchases of property and equipment 

Net cash used in investing activities 

FINANCING ACTIVITIES 

Proceeds from issuance of common stock, net of cash paid for issuance costs 
Proceeds from  issuance of convertible debt 
Repayment of convertible debt 
Repayment of offering and deferred financing costs 
Repayment of related party notes payable 
Restricted cash – convertible debenture holder escrow account funds 
Proceeds from release of restricted cash 
Payment on line of credit 
Proceeds from exercise of options and warrants 
Net cash provided by financing activities 

Net change in cash and cash equivalents 
Cash and cash equivalents, beginning of year 
Cash and cash equivalents, end of year 
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION 

Cash paid during the year for: 
Interest 
Income taxes 

SUPPLEMENTAL DISCLOSURE OF NON-CASH INVESTING AND FINANCING 

ACTIVITIES: 

Offering costs in connection with equity financing included in accounts payable 

Deferred financing costs in connection with convertible debt payable included in accounts 

payable 

Release of restricted cash for repayment of convertible debentures payable 

Cashless exercise of warrants and stock options 

  $ 

  $ 

  $ 

  $ 

  $ 

See accompanying notes to consolidated financial statements.  

393,959       
17,514       
-      

693,180       
(16,486 )     
17,046       
51,033       
-      

(70,973 )     
12,542       
34,912      
443,568       
(18,564 )     
39,558       
(4,785,144 )     

(22,482 )     
(156,200 )     

(178,682 )     

-      
1,294,500       
(82,800 )     
(206,305 )     
(96,000 )     
-      
-      
-      
-      
909,395       
(4,054,431 )     
4,617,535       
563,104     $ 

343,029   
197,225   
156,999   

559,091   
(119,163 ) 
-  
8,362   
(274 ) 

(90,330 ) 
(7,530 ) 
174,151   
(62,241 ) 
(166,750 ) 
60,225   
(6,780,134 ) 

(125,420 ) 
(262,641 ) 

(388,061 ) 

4,718,880   
-  
(2,273,028 ) 
(158,270 ) 
(102,000 ) 
(251,368 ) 
91,443   
(90,000 ) 
571,630   
2,507,287   
(4,660,908 ) 
9,278,443   
4,617,535   

15,676       
1,600       

113,305   
1,600   

53,747     $ 

78,480   

38,475     $ 

251,368     $ 

—    $ 

—  

—  

36   

   
   
   
   
   
  
  
  
  
  
  
  
  
    
        
    
    
        
    
    
    
    
    
    
    
    
    
    
        
    
    
    
    
    
    
    
    
    
        
    
    
    
  
  
  
    
  
  
    
    
    
        
    
    
    
    
    
    
    
    
    
    
    
    
    
    
        
    
    
        
    
    
    
    
        
    
  
  
  
    
  
  
    
  
    
        
    
  
    
        
    
F- 6 

CRYOPORT, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS  

Note 1. Organization and Summary of Significant Accounting Policies  

The Company  

Cryoport, Inc. (the “Company”, “Cryoport” or “we”) serves the biotech industries providing comprehensive solutions for frozen cold chain 

logistics, primarily in the life science industries. Its solutions are novel, new and reliable alternatives to currently existing products and services 
utilized for frozen shipping of bio-pharmaceuticals and biologics, including stem cells, cell lines, vaccines, diagnostic materials, semen and 
embryos for in-vitro fertilization, cord blood, bio-pharmaceuticals, infectious substances and other items that require continuous exposure to 
frozen or cryogenic temperatures. Cryoport’s solutions can contribute to both the efficiency and effectiveness of clinical trials.  

The Cryoport Express ® Solution includes a web-based logistics platform branded as the Cryoportal TM (formerly referred to as the 
Cryoport Express ® Portal). The Cryoportal manages customer ordering, tracking, customs documentation, and communication through a single 
interface as well as enabling the monitoring of a shipment’s location and integrity throughout the entire shipping process. In addition, the 
Cryoportal provides an array of information dashboards and validation documentation for every shipment.  

Integral to this solution are also, in part, the Cryoport Liquid Nitrogen Dry Vapor Shippers (Cryoport Express ® Shippers) which are cost-

effective and reusable cryogenic transport containers (patented vacuum flasks) utilizing innovative liquid nitrogen (LN2) based technology. 
Cryoport Express ® Shippers are non-hazardous, IATA (International Air Transport Association) certified, and are validated to maintain stable 
temperatures below minus 150° Celsius for a 10-plus day dynamic shipment period. The Company currently features two Cryoport Express 
Shipper models, the Standard Dry Shipper (holding up to approximately 75-2.0 ml vials) and the High Volume Dry Shipper (holding up to 
approximately 500-2.0 ml vials).  

The Cryoport Express ® Solutions provide a fully documented “chain-of-custody” and at customer request “chain-of-condition” for every 
shipment, helping ensure that quality, safety, efficacy, and stability of shipped commodities are maintained. Cryoport Express ® Solutions can be 
used by customers, as a “turnkey” solution, through direct access to the cloud-based Cryoportal, or by contacting Cryoport client Care for order 
entry tasks. Cryoport provides 24/7/365 logistics services through its Client Care team and also provides complete training and process 
management services to support each customer’s requirements.  

Cryoport Express ® Solutions have been the Company’s principal focus for development and commercialization. In addition, during the 

first half of fiscal year 2013, the Company expanded its solutions to address specific market needs in the biotechnology and life science 
industries. The primary Cryoport solutions offerings are as follows:  

•  Cryoport Express ® Solution 

The fully outsourced turn-key logistics solution described above.  

•  Customer-Staged Solution 

Cryoport ships an inventory of Cryoport Express ® Shippers to the customer (uncharged and in bulk) enabling the customer to 
charge the shippers at their facility, process their orders through the Cryoportal which Cryoport Client Care to oversee each 
shipment and return the shippers to Cryoport for cleaning, testing and refurbishing. Cryoport provides the 24/7/365 logistics 
services utilizing its Cryoportal logistics platform.  

•  Customer-Managed Solution 

Cryoport ships a fully charged Cryoport Express ® Shipper(s) to the customer enabling the customer to utilize their internal 
expertise to manage all or a portion of the logistics services. As with the above solutions, the shippers are returned to Cryoport 
for cleaning, testing and refurbishing within a pre-determined time period.  

•  Customer Integrated Logistics 

The Cryoport logistics team provides a tailored and full range of logistics support solutions. In addition to tailoring a 
management solution, the robust, enterprise-grade Cryoportal is used to provide complete logistics services while enabling the 
customer to utilize their own packaging solutions or Cryoport Express ® Shippers. Cryoport can provide onsite logistics 
personnel, allowing the customer to fully outsource their cold chain logistics needs component to Cryoport to focus on its core 
competencies.  

•  Distribution Partnerships 

“Powered by Cryoport” are important partnership arrangements with integrators, freight forwarders and other logistics 

    
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
providers, enabling partners to expand their solutions offering by adding the total Cryoport Express® Solution to their 
customer offering.  

F- 7 

   
One of our distribution partnership solutions engagements involves an agreement with Federal Express Corporation (“FedEx”) to provide 

frozen shipping logistics services through the combination of our purpose built proprietary technologies and turnkey management processes. 
FedEx markets and sells Cryoport’s services for frozen temperature-controlled cold chain transportation as its FedEx ® Deep Frozen Shipping 
Solution, on a non-exclusive basis and at its sole expense. During fiscal year 2013, the Company worked closely with FedEx to further align its 
sales efforts and accelerate penetration within FedEx’s life sciences customer base through improved processes, sales incentives, joint customer 
calls and more frequent communication at the sales and executive level. In addition, the Company has developed a FedEx branded portal, which 
is “powered by the Cryoport”, for use by FedEx and its customers giving them access to the full capabilities of our logistics management 
platform.  

During the fourth quarter of fiscal 2013, the Company entered into a master agreement (“FedEx Agreement”) with FedEx renewing these 

services and providing FedEx with a non-exclusive license and right to use a customized version of our Cryoportal for the management of 
shipments made by FedEx customers. The Agreement was effective on January 1, 2013 and, unless sooner terminated as provided in the FedEx 
Agreement, expires on December 31, 2015.  

The Company continues its agreement with another global courier, DHL Express (USA), Inc. (“DHL”) that gives DHL life science 

customers direct access to the Company’s web-based order entry and tracking portal to order CryoPort Express ® Dry Shippers and receive 
preferred DHL shipping rates. The agreement covers DHL shipping discounts that may be used to support the Company’s customers using 
Cryoport Express ® Solutions. In connection with the agreement, the Company has integrated its proprietary web portal to DHL’s tracking and 
billing systems to provide DHL life science customers with a seamless way of shipping their critical biological material worldwide.  

In December 2012, we signed an agreement with Pfizer Inc. relating to Zoetis Inc. (formerly the animal health business unit of Pfizer Inc., 
“Zoetis”) pursuant to which we were engaged to manage frozen shipments of a key poultry vaccine. Under this arrangement, the Company will 
provide on-site logistics personnel and its logistics management platform, the Cryoportal TM , to manage shipments from the Zoetis 
manufacturing site in the United States to domestic customers as well as various international distribution centers. As part of its logistics 
management services, the Company will analyze shipping data and processes to further streamline Zoetis’ logistics, ensuring products arrive to 
their destinations in specified conditions, on-time and with the optimum uses of resources. Initially, the Company will manage Zoetis’ total fleet 
of dewar flask shippers used for this purpose, including liquid nitrogen shippers.  

We offer our solutions to companies in the biotechnology and life science industries and are targeting specific verticals including biotech 
and diagnostic companies, pharmaceutical companies, central laboratories, contract research organizations, the reproductive medicine market/in 
vitro fertilization market, and research institutions. These companies operate within a heavily regulated environment and as such, changing 
vendors and distribution practices typically require a number of steps, which may include the audit of our facilities, review of our procedures, 
qualifying us as a vendor, and performing test shipments. This process can take six to eighteen months or longer to complete prior to a potential 
customer adopting the Cryoport Express ® Solution.  

Going Concern  

The consolidated financial statements have been prepared using the accrual method of accounting in accordance with accounting principles 

generally accepted in the United States of America (“U.S.”) (“GAAP”) and have been prepared on a going concern basis, which contemplates 
the realization of assets and the settlement of liabilities in the normal course of business. We have sustained operating losses since our inception 
and have used substantial amounts of working capital in our operations. Further, at March 31, 2013, we had an accumulated deficit of 
$66,311,448 and we had a net loss of $6,382,433 and we used cash in operations of $4,785,144 during the year ended March 31, 2013. These 
factors raise substantial doubt about our ability to continue as a going concern.  

We expect to continue to incur substantial additional operating losses from costs related to the commercialization of our Cryoport Express 

® Solutions and do not expect that revenues from operations will be sufficient to satisfy our funding requirements in the near term. We believe 
that our cash resources at March 31, 2013, together with the revenues generated from our services, the continued focus on cost reductions of 
non-sales generating costs will be sufficient to sustain our planned operations into the second quarter of fiscal year 2014; however, we must 
obtain additional capital to fund operations thereafter and for the achievement of sustained profitable operations. We are currently working on 
funding alternatives in order to secure sufficient operating capital to allow us to continue to operate as a going concern.  

Future capital requirements will depend upon many factors, including the success of our commercialization efforts and the level of 
customer adoption of our Cryoport Express ® Solutions as well as our ability to establish additional collaborative arrangements. We cannot make 
any assurances that the sales ramp together with cost reduction measures will lead to achievement of sustained profitable operations or that any 
additional financing will be completed on a timely basis, on acceptable terms or at all. Management’s inability to successfully achieve significant 
revenue increases or its cost reduction strategies, or to complete any other financing will adversely impact our ability to continue as a going 
concern. To address this issue, the Company has instituted cost containment measures and is seeking additional capitalization to properly fund its 
efforts to become a self-sustaining financially viable entity.    

F- 8 

   
   
   
   
   
   
   
   
   
   
  
Basis of Presentation  

The accompanying consolidated financial statements have been prepared in accordance with GAAP.  

Principles of Consolidation  

The consolidated financial statements include the accounts of CryoPort, Inc. and its wholly owned subsidiary, CryoPort Systems, Inc. All 

intercompany accounts and transactions have been eliminated.  

Use of Estimates  

The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions 
that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements 
and the reported amounts of revenues and expenses during the reporting periods. Actual results could differ from estimated amounts. The 
Company’s significant estimates include allowances for doubtful accounts, recoverability of long-lived assets, allowance for inventory 
obsolescence, deferred taxes and their accompanying valuations, valuation of derivative liabilities and valuation of common stock, warrants and 
stock options issued for products or services.  

Fair Value of Financial Instruments  

The Company’s financial instruments consist of cash and cash equivalents, restricted cash, accounts receivable, related-party notes 
payable, convertible notes payable, accounts payable and accrued expenses. The carrying value for all such instruments approximates fair value 
at March 31, 2013 and 2012. The difference between the fair value and recorded values of the related party notes payable is not significant. The 
Company’s restricted cash is carried at amortized cost which approximates fair value at March 31, 2013 and 2012.  

Cash and Cash Equivalents  

The Company considers highly liquid investments with original maturities of 90 days or less to be cash equivalents.  

Concentrations of Credit Risk  

The Company maintains its cash accounts in financial institutions. Accounts at these institutions are insured by the Federal Deposit 
Insurance Corporation (“FDIC”) with basic deposit insurance coverage limits up to $250,000 per owner. At March 31, 2013 and 2012, the 
Company had approximately $214,000 and $0, respectively, which exceeded the FDIC insurance limit, of cash balances, including restricted 
cash. The Company performs ongoing evaluations of these institutions to limit its concentration risk exposure.  

Restricted Cash  

In conjunction with the private placement in February 2012, the Company was required to deposit $444,168 into an escrow account 

representing the total future principal payments due to one the convertible debenture holders (see Note 8). At March 31, 2012, $251,368 
remained in escrow and was disbursed to the note holder during the first quarter of fiscal year 2013. Previously, the Company also invested cash 
in a one year restricted certificate of deposit bearing interest at 1% which served as collateral for borrowings under a line of credit agreement 
(see Note 6). During 2012 the Company repaid the line of credit and the previously restricted cash balances were released to the Company.  

Customers  

The Company grants credit to customers within the U.S. and to a limited number of international customers and does not require collateral. 
Revenues from international customers are generally secured by advance payments except for a limited number of established foreign customers. 
The Company generally requires advance or credit card payments for initial revenues from new customers. The Company’s ability to collect 
receivables is affected by economic fluctuations in the geographic areas and industries served by the Company. Reserves for uncollectible 
amounts are provided based on past experience and a specific analysis of the accounts, which management believes is sufficient. Accounts 
receivable at March 31, 2013 and 2012 are net of reserves for doubtful accounts of $8,700 and $5,500, respectively. Although the Company 
expects to collect amounts due, actual collections may differ from the estimated amounts.  

The Company has foreign revenues primarily in Europe, Japan, Canada, India and Australia. During fiscal years 2013 and 2012, the 
Company had foreign revenues of approximately $460,000 and $301,000, respectively, which constituted approximately 42% and 54% of total 
revenues, respectively.  

F- 9 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
The majority of the Company’s customers are in the biotechnology, pharmaceutical and life science industries. Consequently, there is a 

concentration of receivables within these industries, which is subject to normal credit risk. At March 31, 2013, no customers accounted for more 
than 10% of revenues. At March 31, 2012, annual revenues from two major customers accounted for 26% of our total revenues. The Company 
maintains reserves for bad debt and such losses, in the aggregate, historically have not exceeded our estimates.  

Inventories  

The Company’s inventories consist of accessories that are sold and shipped to customers along with pay-per-use containers that are not 
returned to the Company along with the containers at the culmination of the customer’s shipping cycle . Inventories are stated at the lower of 
cost or current estimated market value. Cost is determined using the standard cost method which approximates the first-in, first-to-expire 
method. Inventories are reviewed periodically for slow-moving or obsolete status. The Company writes down the carrying value of its 
inventories to reflect situations in which the cost of inventories is not expected to be recovered. Once established, write-downs of inventories are 
considered permanent adjustments to the cost basis of the obsolete or excess inventories. Raw materials and finished goods include material 
costs less reserves for obsolete or excess inventories. The Company evaluates the current level of inventories considering historical trends and 
other factors, and based on the evaluation, records adjustments to reflect inventories at its net realizable value. These adjustments are estimates, 
which could vary significantly from actual results if future economic conditions, customer demand, competition or other relevant factors differ 
from expectations. These estimates require us to make assessments about future demand for the Company’s products in order to categorize the 
status of such inventories items as slow-moving, obsolete or in excess-of-need. These estimates are subject to the ongoing accuracy of the 
Company’s forecasts of market conditions, industry trends, competition and other factors.  

Property and Equipment  

The Company provides shipping containers to its customers and charges a fee in exchange for the use of the container. The Company’s 

arrangements are similar to the accounting standard for leases since they convey the right to use the container over a period of time. The 
Company retains the title to the containers and provides its customers the use of the container for a specific shipping cycle. At the culmination of 
the customer’s shipping cycle, the container is returned to the Company. As a result, the Company classifies the containers as fixed assets for the 
per-use container program.  

Property and equipment are recorded at cost. Cryogenic shippers, which comprise of 87% and 84% of the Company’s net property and 

equipment balance at March 31, 2013 and 2012, respectively, are depreciated using the straight-line method over their estimated useful lives of 
three years. Equipment and furniture are depreciated using the straight-line method over their estimated useful lives (generally three to seven 
years) and leasehold improvements are amortized using the straight-line method over the estimated useful life of the asset or the lease term, 
whichever is shorter. Equipment acquired under capital leases is amortized over the estimated useful life of the assets or term of the lease, 
whichever is shorter and included in depreciation expense.  

Betterments, renewals and extraordinary repairs that extend the lives of the assets are capitalized; other repairs and maintenance charges 

are expensed as incurred. The cost and related accumulated depreciation and amortization applicable to assets retired are removed from the 
accounts, and the gain or loss on disposition is recognized in current operations.  

Intangible Assets  

Intangible assets are comprised of patents and trademarks and software development costs. The Company capitalizes costs of obtaining 

patents and trademarks, which are amortized, using the straight-line method over their estimated useful life of five years. The Company 
capitalizes certain costs related to software developed for internal use. Software development costs incurred during the preliminary or 
maintenance project stages are expensed as incurred, while costs incurred during the application development stage are capitalized and amortized 
using the straight-line method over the estimated useful life of the software, which is five years. Capitalized costs include purchased materials 
and costs of services including the valuation of warrants issued to consultants.  

Long-lived Assets  

If indicators of impairment exist, we assess the recoverability of the affected long-lived assets by determining whether the carrying value 

of such assets can be recovered through undiscounted future operating cash flows. If impairment is indicated, we measure the amount of such 
impairment by comparing the fair value to the carrying value. We believe the future cash flows to be received from the long-lived assets will 
exceed the assets’ carrying value, and accordingly, we have not recognized any impairment losses through March 31, 2013.  

F- 10 

   
   
   
   
   
   
   
   
   
   
   
   
  
Deferred Financing Costs  

Deferred financing costs represent costs incurred in connection with the issuance of the convertible notes payable and private equity 
financing. Deferred financing costs related to the issuance of debt are being amortized over the term of the financing instrument using the 
effective interest method while deferred financing costs from equity financings are netted against the gross proceeds received from the equity 
financings.  

During the year ended March 31, 2013 and 2012, the Company incurred $103,542 and $572,255, respectively of offering costs in 
connection with the private placement that closed in February and March 2012, which were charged to additional paid-in capital and netted 
against the proceeds received in the private placements. As of March 31, 2013 and 2012, offering costs of $53,747 and$78,480, respectively, 
related to the private placement were included in accounts payable and accrued expenses in the accompanying consolidated balance sheets.  

In connection with the convertible debt financing in the fourth quarter of 2013, the Company incurred financing costs which were 
capitalized and are being amortized over the term of the convertible notes payable using the straight-line method which approximates the 
effective interest method (see Note 8).  

During the year ended March 31, 2011, the Company incurred $465,023 of offering costs in connection with the private placement that 
closed in August and October 2010 and $1,311,582 of offering costs from the private placement that closed in February 2011; both of which 
were charged to additional paid-in capital and netted against the proceeds received in the private placements. During the year ended March 31, 
2012, the Company made payments of $158,270 for offering costs and financing fees related to the February 2011 private placement of which 
$121,727 was included in accounts payable and accrued expenses as of March 31, 2011.  

Convertible Debentures  

If a conversion feature of conventional convertible debt is not accounted for as a derivative instrument and provides for a rate of 

conversion that is below market value, this feature is characterized as a beneficial conversion feature (“BCF”). A BCF is recorded by the 
Company as a debt discount. The convertible debt is recorded net of the discount related to the BCF. The Company amortizes the discount to 
interest expense over the life of the debt using the effective interest rate method.  

Derivative Liabilities  

Certain of the Company’s issued and outstanding common stock purchase warrants which have exercise price reset features are treated as 
derivatives for accounting purposes. The common stock purchase warrants were not issued with the intent of effectively hedging any future cash 
flow, fair value of any asset, liability or any net investment in a foreign operation. The warrants do not qualify for hedge accounting, and as such, 
all future changes in the fair value of these warrants are recognized currently in earnings until such time as the warrants are exercised, expire or 
the related rights have been waived. These common stock purchase warrants do not trade in an active securities market, and as such, the 
Company estimates the fair value of these warrants using the Black-Scholes option pricing model (“Black-Scholes”) (see Note 9).  

Commitments and Contingencies  

The Company is subject to routine claims and litigation incidental to our business. In the opinion of management, the resolution of such 

claims is not expected to have a material adverse effect on our operating results or financial position.  

Income Taxes  

The Company accounts for income taxes under the provision of the Financial Accounting Standards Board (“FASB”) Accounting 
Standards Codification (“ASC”) 740, Income Taxes , or ASC 740. The Company is a subchapter “C” corporation and files a federal income tax 
return. The Company files state income tax returns in California.  

Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those 

temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is 
recognized in income in the period that includes the enactment date. A valuation allowance is provided for certain deferred tax assets if it is more 
likely than not that the Company will not realize tax assets through future operations. Based on the weight of available evidence, the Company’s 
management has determined that it is more likely than not that the net deferred tax assets will not be realized. Therefore, the Company has 
recorded a full valuation allowance against the net deferred tax assets. The Company’s income tax provision consists of state minimum taxes.  

ASC 740, which clarifies the accounting for uncertainty in income taxes recognized in the financial statements, provides that a tax benefit 
from an uncertain tax position may be recognized when it is more likely than not that the position will be sustained upon examination, including 
resolutions of any related appeals or litigation processes, based on the technical merits. Income tax positions must meet a more likely than not 
recognition threshold. As of March 31, 2013 and 2012, there were no unrecognized tax benefits included in the accompanying consolidated 
balance sheets that would, if recognized, affect the effective tax rates. It is not anticipated that there will be a significant change in the 
unrecognized tax benefits over the next twelve months.  

F- 11 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
The Company’s policy is to recognize interest and/or penalties related to income tax matters in income tax expense. The Company had no 

accrual for interest or penalties on its consolidated balance sheets at March 31, 2013 and 2012, respectively and has not recognized interest 
and/or penalties in the consolidated statement of operations for the years ended March 31, 2013 and 2012. The Company is subject to taxation in 
the U.S. and various state jurisdictions. As of March 31, 2013, the Company is no longer subject to U.S. federal examinations for years before 
2009 and for California franchise and income tax examinations for years before 2008. However, to the extent allowed by law, the taxing 
authorities may have the right to examine prior periods where net operating losses were generated and carried forward, and make adjustments up 
to the amount of the net operating loss carry forward amount. The Company is not currently under examination by U.S. federal or state 
jurisdictions.  

Supply Concentration Risks  

The component parts for our products are primarily manufactured at third party manufacturing facilities. The Company also has a 
warehouse at our corporate offices in Lake Forest, California, where the Company is capable of manufacturing certain parts and fully assembles 
its products. Most of the components that the Company uses in the manufacture of its products are available from more than one qualified 
supplier. For some components, however, there are relatively few alternate sources of supply and the establishment of additional or replacement 
suppliers may not be accomplished immediately, however, the Company has identified alternate qualified suppliers which the Company believes 
could replace existing suppliers. Should this occur, the Company believes that with its current level of shippers and production rate the Company 
has enough to cover a four to six week gap in maximum disruption of production.  

There are no specific agreements with any manufacturer nor are there any long term commitments to any manufacturer. The Company 

believes that any of the manufactures currently used by it could be replaced within a short period of time as none have a proprietary component 
or a substantial capital investment specific to its products.  

Revenue Recognition  

The Company provides shipping containers to their customers and charges a fee in exchange for the use of the container. The Company’s 

arrangements are similar to the accounting standard for leases since they convey the right to use the containers over a period of time. The 
Company retains title to the containers and provides its customers the use of the container for a specified shipping cycle. At the culmination of 
the customer’s shipping cycle, the container is returned to the Company.  

The Company recognizes revenue for the use of the shipper at the time of the delivery of the shipper to the end user of the enclosed 

materials, and at the time that collectability is reasonably certain. Revenue is based on gross net of discounts and allowances.  

The Company also provides logistics support and management to some customers, which may include onsite logistics personnel. Revenue 

is recognized for these services as services are rendered and at the time that collectability is reasonably certain.  

Accounting for Shipping and Handling Revenue, Fees and Costs  

The Company classifies amounts billed for shipping and handling as revenue. Shipping and handling fees and costs are included in cost of 

sales in the accompanying consolidated statements of operations.  

Research and Development Expenses  

Expenditures relating to research and development are expensed in the period incurred. Research and development expenses to date have 
consisted primarily of costs associated with the continually improving the features of the CryoPort Express ® Solution including the web based 
customer service portal and the CryoPort Express ® Shippers. Further, these efforts are expected to lead to the introduction of shippers of varying 
sizes based on market requirements, constructed of lower cost materials and utilizing high volume manufacturing methods that will make it 
practical to provide the cryogenic packages offered by the CryoPort Express ® Solution. Other research and development effort has been directed 
toward improvements to the liquid nitrogen retention system to render it more reliable in the general shipping environment and to the design of 
the outer packaging. Alternative phase change materials in place of liquid nitrogen may be used to increase the potential markets these shippers 
can serve such as ambient and 2-8°C markets.  

F- 12 

   
   
   
   
   
   
   
   
   
   
   
   
  
Stock-based Compensation  

The Company accounts for stock-based payments to employees and directors in accordance with stock-based payment accounting 
guidance which requires all stock-based payments to employees and directors, including grants of employee stock options and warrants, to be 
recognized based upon their fair values. The fair value of stock-based awards is estimated at grant date using Black-Scholes and the portion that 
is ultimately expected to vest is recognized as compensation cost over the requisite service period.  

Since stock-based compensation is recognized only for those awards that are ultimately expected to vest, the Company has applied an 

estimated forfeiture rate to unvested awards for the purpose of calculating compensation cost. These estimates will be revised, if necessary, in 
future periods if actual forfeitures differ from estimates. Changes in forfeiture estimates impact compensation cost in the period in which the 
change in estimate occurs. The estimated forfeiture rates at March 31, 2013 and 2012 was zero as the Company has not had a significant history 
of forfeitures and does not expect significant forfeitures in the future.  

Cash flows from the tax benefits resulting from tax deductions in excess of the compensation cost recognized for those options or warrants 

are classified as financing cash flows. Due to the Company’s loss position, there were no such tax benefits during years ended March 31, 2013 
and 2012.  

The Company uses Black-Scholes to estimate the fair value of stock-based awards. The determination of fair value using Black-Scholes is 

affected by its stock price as well as assumptions regarding a number of complex and subjective variables, including expected stock price 
volatility, risk-free interest rate, expected dividends and projected employee stock option exercise behaviors.  

The Company’s stock-based compensation plans are discussed further in Note 11.  

Equity Instruments Issued to Non-Employees for Acquiring Goods or Services  

Issuances of the Company’s common stock for acquiring goods or services are measured at the fair value of the consideration received or 

the fair value of the equity instruments issued, whichever is more reliably measurable. The measurement date for the fair value of the equity 
instruments issued to consultants or vendors is determined at the earlier of (i) the date at which a commitment for performance to earn the equity 
instruments is reached (a “performance commitment” which would include a penalty considered to be of a magnitude that is a sufficiently large 
disincentive for nonperformance) or (ii) the date at which performance is complete. When it is appropriate for the Company to recognize the cost 
of a transaction during financial reporting periods prior to the measurement date, for purposes of recognition of costs during those periods, the 
equity instrument is measured at the then-current fair values at each of those interim financial reporting dates (see Note 12).  

Basic and Diluted Loss Per Share  

Basic loss per common share is computed based on the weighted average number of shares outstanding during the period. Diluted loss per 
share is computed by dividing net loss by the weighted average shares outstanding assuming all dilutive potential common shares were issued. In 
addition, in computing the dilutive effect of convertible securities, the numerator is adjusted to add back the after-tax amount of interest, if any, 
recognized in the period with any convertible debt. For the years ended March 31, 2013 and 2012, the Company was in a loss position and the 
basic and diluted loss per share are the same since the effect of stock options, warrants and convertible notes payable on loss per share was anti-
dilutive and thus not included in the diluted loss per share calculation. The impact under the treasury stock method of dilutive stock options and 
warrants and the if-converted method of convertible debt would have resulted in weighted average common shares outstanding of approximately 
38,172,000 and 34,128,000 for the years ended March 31, 2013 and 2012, respectively.  

Segment Reporting  

We currently operate in only one segment.  

Note 2. Inventories  

Inventories consist of the following:  

Raw materials 
Finished goods 

March 31,  
2013 

March 31,  
2012 

  $ 

  $ 

28,533     $ 
10,679       
39,212     $ 

32,559   
19,195   
51,754   

F- 13 

    
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
    
  
    
  
The Company’s inventories consists of accessories that are sold and shipped to customers along with pay-per-use containers and are not 

returned to the Company along with the containers at the culmination of the customer’s shipping cycle. Inventories are stated at the lower of 
standard cost or current estimated market value. Cost is determined using the standard cost method which approximates the first-in, first-to-
expire method.  

Note 3. Property and Equipment  

Equipment and leasehold improvements and related accumulated depreciation and amortization are as follows:  

Cryogenic shippers 
Furniture and fixtures 
Machinery and equipment 
Leasehold improvements 

Less accumulated depreciation and amortization 

March 31, 

2013 

2012 

962,565     $ 
30,746       
380,526       
30,913       
1,404,750       
(899,265 )     
505,485     $ 

882,471   
30,746   
377,919   
30,913   
1,322,049   
(640,028 ) 
682,021   

  $ 

  $ 

The Company’s current business plan focuses on per-use leasing of shipping containers and added-value services that will be used by us to 

provide an end-to-end and cost-optimized shipping solutions.  

Total depreciation and amortization expense related to property and equipment amounted to $281,703 and $241,838 for the years ended 

March 31, 2013 and 2012, respectively.  

Note 4. Intangible Assets  

Intangible assets are comprised of patents and trademarks and software developed for internal uses. The gross book values and 

accumulated amortization as of March 31, 2013 and 2012 were as follows:  

Patents and trademarks 
Software development costs 

Less accumulated amortization 

March 31, 

2013 

2012 

154,214     $ 
547,127       
701,341       
(429,078 )     
272,263     $ 

131,856   
564,049   
695,905   
(316,822 ) 
379,083   

  $ 

  $ 

Amortization expense for intangible assets for the years ended March 31, 2013 and 2012 was $112,256 and $101,191, respectively. All of 

the Company’s intangible assets are subject to amortization.  

Years Ending March 31,  
2014 
2015 
2016 
2017 
2018 

Note 5. Fair Value Measurements  

Patents and  
Trademarks  

Software  

Total  
Intangibles  

  $ 

  $ 

21,078     $ 
20,034       
19,617       
19,617       
19,617       
99,963     $ 

90,715     $ 
42,851       
30,153       
8,581       
-      
172,300     $ 

111,793   
62,885   
49,770   
28,198   
19,167   
272,263   

The Company determines the fair value of its derivative instruments using a three-level hierarchy for fair value measurements which these 

assets and liabilities must be grouped, based on significant levels of observable or unobservable inputs. Observable inputs reflect market data 
obtained from independent sources, while unobservable inputs reflect the Company’s market assumptions. This hierarchy requires the use of 
observable market data when available. These two types of inputs have created the following fair-value hierarchy:  

Level 1 — Valuations based on unadjusted quoted market prices in active markets for identical securities. Currently the Company does not 

have any items classified as Level 1.  

F- 14 

    
   
   
   
   
   
   
   
   
   
   
    
   
   
   
  
  
  
  
  
  
    
  
    
    
    
  
    
    
  
  
  
  
  
  
    
  
    
  
    
    
  
  
    
    
  
    
    
    
    
  
Level 2 — Valuations based on observable inputs (other than Level 1 prices), such as quoted prices for similar assets at the measurement 

date; quoted prices in markets that are not active; or other inputs that are observable, either directly or indirectly.  

Level 3 — Valuations based on inputs that are unobservable and significant to the overall fair value measurement, and involve 

management judgment. The Company uses the Black-Scholes option pricing model to determine the fair value of the instruments. If the inputs 
used to measure fair value fall in different levels of the fair value hierarchy, a financial security’s hierarchy level is based upon the lowest level 
of input that is significant to the fair value measurement.  

The following table presents the Company’s warrants measured at fair value on a recurring basis as of March 31, 2013 and 2012 classified 

using the valuation hierarchy:  

Derivative Liabilities 

Level 3  
Carrying Value 
March 31, 2013     
  $ 

20,848     $ 

Level 3  
Carrying Value 
March 31, 2012   
37,334   

The following table provides a reconciliation of the beginning and ending balances for the Company’s derivative liabilities measured at 

fair value using Level 3 inputs:  

Balance at April 1, 
Change in fair value 
Balance at March 31, 

Note 6. Line of Credit  

2013 

2012 

37,334     $ 
(16,486 )     
20,848     $ 

156,497   
(119,163 ) 
37,334   

  $ 

  $ 

During October 2010, the Company secured a one-year renewal of the line of credit (the “Line”) for $90,000 which was secured by a 
$90,000 certificate of deposit with a financial institution. On August 23, 2011 the Company paid the entire balance in full and the line has been 
terminated. All borrowings under the Line bore variable interest based on either the prime rate plus 1.5% per annum or 5.0%, whichever was 
higher. The Company utilized the funds advanced from the Line for capital equipment purchases to support the commercialization of the 
Company’s CryoPort Express ® Dry Shipper. No funds were drawn against the Line during the years ended March 31, 2013 and 2012. The 
Company recorded interest expense of $0 and $1,725 for the years ended March 31, 2013 and 2012, respectively, related to the Line.  

Note 7. Related Party Transactions  

Related Party Notes Payable  

As of March 31, 2013 and 2012, the Company had aggregate principal balances of $651,500 and $747,500, respectively, in outstanding 

unsecured indebtedness owed to four related parties, including former members of the Company’s board of directors, representing working 
capital advances made to the Company from February 2001 through March 2005. These notes bear interest at the rate of 6% per annum and 
provide for aggregate monthly principal payments which began April 1, 2006 of $2,500, and which increased by an aggregate of $2,500 every 
nine months to a maximum of $10,000 per month. As of March 31, 2013, the aggregate principal payments totaled $8,000 per month. Any 
remaining unpaid principal and accrued interest is due at maturity on various dates through March 1, 2015.  

Related-party interest expense under these notes was $42,216 and $48,036 for the years ended March 31, 2013 and 2012, respectively. 

Accrued interest related to these notes, which is included in related party notes payable in the accompanying consolidated balance sheets, 
amounted to $766,164 and $723,948 as of March 31, 2013 and 2012, respectively.  

Scheduled maturities of related party notes payable, including accrued interest, as of March 31, 2013 are as follows:  

Years Ending March 31: 
2014 
2015 

  $ 

  $ 

96,000   
1,321,664   
1,417,664   

F- 15 

   
   
   
   
   
   
   
   
   
   
   
   
   
   
    
  
  
  
  
  
    
  
    
    
    
    
  
Advisory Services Agreement with Former Officer  

On March 7, 2011 the Company entered into a one-year Advisory Services Agreement with Marc Grossman M.D. to provide strategic 

business advisory services including identifying and introducing customers, advising on sales and marketing plans and providing financial 
advice. Dr. Grossman is a former officer of the Company and is one of the four related parties to which CryoPort has an outstanding unsecured 
debt obligation. For these services, Dr. Grossman was paid a fee of $125,000, which was amortized over the term of the agreement, and issued a 
warrant to purchase 200,000 shares of the Company’s common stock at an exercise price of $0.77 per share, a five year life and vested upon 
issuance (see Note 12).  

Consulting Agreement with Officer  

On July 29, 2009, the Board of Directors of the Company appointed Ms. Catherine M. Doll, a consultant, to the offices of Chief Financial 

Officer, Treasurer and Assistant Corporate Secretary, which became effective on August 20, 2009. Ms. Doll resigned the offices of Chief 
Financial Officer, Treasurer and Assistant Corporate Secretary on June 27, 2011, effective immediately following the Company’s filing of its 
Form 10-K for the fiscal year ended March 31, 2011. Ms. Doll is the owner and chief executive officer of The Gilson Group, LLC. The Gilson 
Group, LLC provided financial and accounting consulting services, including SEC and financial reporting, budgeting and forecasting to the 
Company. Related-party consulting fees for all services provided by The Gilson Group, LLC, were approximately $0 and $76,000 for the years 
ended March 31, 2013 and 2012, respectively.  

Note 8. Convertible Debentures Payable  

The Company’s convertible debenture principal balances are shown below:  

Convertible Debt 
Debt discount 
Total convertible debentures, net 

Convertible debentures payable and accrued interest, net of discount of $0 in 2013 and $8,843 in 2012 

March 31,  
2013 
1,294,500     $ 
-      
1,294,500     $ 
1,304,419     $ 

  $ 

  $ 
  $ 

March 31,  
2012 

334,168   
(8,843 ) 
325,325   
337,902   

F- 16 

   
   
   
   
   
   
   
   
  
  
  
    
  
    
During the years ended March 31, 2013 and 2012, the Company recognized an aggregate of $8,843 and $197,225 in interest expense, 
respectively, due to amortization of debt discount related to the warrants and beneficial conversion features associated with the Company’s 
outstanding convertible debentures. During the year ended March 31, 2013 and 2012, the Company recorded interest expense of $13,018 and 
$122,825, respectively, related to the stated interest associated with the Debentures, of which $9,919 and $12,577 is included in convertible 
debentures payable and accrued interest in the accompanying consolidated balance sheets as of March 31, 2013 and 2012, respectively.  

October 2007 and May 2008 Debentures  

The Company issued convertible debentures in October 2007 (the “October 2007 Debentures”) and in May 2008 (the “May 2008 
Debentures,” and together with the October 2007 Debentures, the “Debentures”). The Debentures were issued to four institutional investors and 
had an outstanding principal balance of $0 and $334,168 as of March 31, 2013 and 2012, respectively. In addition, in October 2007 and May 
2008, the Company issued to these institutional investors warrants to purchase, as of March 31, 2013, an aggregate of 3,055,097 shares of the 
Company’s common stock (the “Debenture Warrants”). As collateral to secure our repayment obligations to the holders of the Debentures we 
had granted such holders a first priority security interest in generally all of our assets, including our intellectual property.  

The October 2007 Debentures were convertible into shares of the Company’s common stock at a price of $3.00 per share and bore interest 

at 8% per annum. The Company had been obligated to make principal or additional interest payments since March 1, 2011 with respect to the 
outstanding balances of the October 2007 Debentures. The Company made monthly principal payments of $200,000 and quarterly interest 
payments. The October 2007 Debentures were fully repaid in June 2012.  

As of March 31, 2011, the May 2008 Debentures were paid in full.  

Because the consummation of the private placement in February 2012 would have triggered defaults under the Company’s October 2007 
Debentures, prior to the initial close of the private placement, the Company obtained a waiver from the holders of the October 2007 Debentures 
with respect to such defaults and their consent to the private placement. In consideration for such waiver and consent, the Company, at the initial 
close, issued to the holders of the October 2007 Debentures warrants to purchase an aggregate of 280,000 shares of the Company’s common 
stock at an exercise price of $0.69 per share. The warrants have terms identical to the warrants issued to the investors in the private placement 
(see Note 10).  

2013 Bridge Notes  

In the fourth quarter of fiscal 2013, the Company issued to certain accredited investors unsecured convertible promissory notes (the 
“Bridge Notes”) in the original principal amount of $1,294,500, pursuant to the terms of subscription agreements and letters of investment intent. 

The Bridge Notes accrue interest at a rate of 15% per annum from date of issuance until January 31, 2013 and at a rate of 5% per annum 

from February 1, 2013 through the date of payment, in each case on a non-compounding basis. All principal and interest under the Bridge Notes 
will be due on December 31, 2013. Debt financing costs of $116,505 comprised of agent commissions were recorded in other current assets and 
are being amortized to interest expense under the straight-line method which approximates the effective interest method over the term of the 
notes. During the year ended March 31, 2013, the Company amortized $8,671 to interest expense.  

In the event the Company designated and issued preferred stock while the Bridge Notes were outstanding, the Bridge Notes were 

convertible into shares of such preferred stock at a conversion rate equal to the price per share paid to the Company in connection with the 
issuance of such preferred stock at the option of the holder of the Bridge Notes. The Company was unable to value the conversion feature of 
these Bridge Notes given the absence of a conversion rate the convertability of the Bridge Notes being contingent on the completion of a 
preferred stock transaction.  

Effective on April 19, 2013, the Company amended the Bridge Notes whereby in the event that the Company issues one or more types of 
equity securities (a “Transaction”) before the maturity of the Bridge Notes, the holder may elect to convert all or a portion of the principal and 
accrued interest into shares of such equity securities issued in a Transaction at a conversion rate equal to the price per share paid to the Company 
in connection with the issuances. The Company is required to notify the Bridge Notes holder of a Transaction within 10 days of each Transaction 
and the Bridge Notes holder has the option until the later of (a) ten (10) days after such notices or (b) December 15, 2013 to elect in writing to 
convert the Bridge Notes.  

  Note 9. Derivative Liabilities  

In accordance with current accounting guidance, certain of the Company’s outstanding warrants to purchase shares of common stock are 

treated as derivatives because these instruments have reset or ratchet provisions in the event the Company raises additional capital at a lower 
price, among other adjustments. As such, the fair value of these common stock purchase warrants were treated as derivative liabilities since their 
date of issuance or modification. Changes in fair value are recorded as non-operating, non-cash income or expense at each reporting date. If the 
fair value of the derivatives is higher at the subsequent balance sheet date, the Company will record a non-operating, non-cash charge. If the fair 
value of the derivatives is lower at the subsequent balance sheet date, the Company will record non-operating, non-cash income. As of March 31, 
2013 and 2012 the Company had derivative warrant liabilities of $20,848 and $37,334, respectively.  

F- 17 

    
   
   
   
   
   
   
   
   
   
   
   
   
   
  
During the years ended March 31, 2013 and 2012, the Company issued an aggregate of 0 and 10,289 warrants to purchase shares of the 
Company’s common stock, respectively, pursuant to the anti-dilution provisions contained in the warrant agreements which were previously 
issued to various placement agents in lieu of cash fees. On August 20, 2010, in connection with the August 2010 private placement closing, the 
exercise price of the warrants was reduced from $3.30 per share to $3.20 per share and the Company issued an additional 4,073 warrants. On 
February 4, 2011, in connection with the February 2011 private placement, the exercise price of the warrants was reduced from $3.20 per share 
to $2.81 per share and the Company issued an additional 18,657 warrants. On February 14, 2011, in connection with the February 2011 private 
placement, the exercise price of the warrants was reduced from $2.81 per share to $2.58 per share and the Company issued an additional 13,641 
warrants. On February 22, February 28, and March 7, 2012, in connection with the February 2012 private placement, the Company issued an 
additional 6,721, 2,843 and 725 warrants, respectively, and the exercise price of the warrants was reduced from $2.58 per share to $2.48 per 
share, $2.48 per share to $2.44 per share and $2.44 per share to $2.43 per share, respectively. Since the exercise price of the warrants is subject 
to additional adjustment in the event the Company issues dilutive equity securities, as described in the original warrant agreements, the warrants 
are accounted for as derivative liabilities. During the years ended March 31, 2013 and 2012, the Company recognized aggregate gains of $16,486 
and $119,163, respectively, due to the change in fair value of its derivative instruments. See Note 5 for the components of changes in derivative 
liabilities. The Company’s common stock purchase warrants do not trade in an active securities market, and as such, the Company estimated the 
fair value of these warrants using Black-Scholes using the following assumptions:  

Expected dividends 
Expected term (in years) 
Risk-free interest rate 
Expected volatility 

March 31,  
2013  
— 
1.01 – 1.81 

March 31,  
2012  
— 
2.01 – 2.81 

   0.14% – 0.33% 
129% – 158% 

   0.33% – 0.81% 
124% – 132% 

Historical volatility was computed using daily pricing observations for recent periods that correspond to the remaining term of the 
warrants, which had an original term of five years from the date of issuance. The expected life is based on the remaining term of the warrants. 
The risk-free interest rate is based on U.S. Treasury securities with a maturity corresponding to the remaining term of the warrants.  

Note 10. Stockholders’ Equity  

Preferred Stock  

On September 22, 2011, the Company’s stockholders approved an amendment to the Company’s Amended and Restated Articles of 

Incorporation to authorize a class of undesignated or “blank check” preferred stock, which had previously been approved by the Company’s 
Board of Directors on July 19, 2011, consisting of 2,500,000 shares at $0.001 par value per share. Shares of preferred stock may be issued in one 
or more series, with such rights, preferences, privileges and restrictions as shall be fixed by the Company’s Board of Directors.  

Common Stock  

The Company’s authorized capital consists of 250,000,000 shares of common stock, $0.001 par value per share. As of March 31, 2013 and 

2012, 37,760,628 shares of common stock were issued and outstanding.  

Fiscal Year 2012 Activity  

In February and March 2012, the Company conducted a private placement of units totaling 9,477,554 at a purchase price of $0.55 per unit 
(the “February 2012 Private Placement”) for total proceeds of $4,640,400, net of offering costs of $572,255. Each unit consisted of one share of 
common stock and one warrant to purchase one share of common stock at an exercise price of $0.69 per share. Each warrant is fully exercisable 
six months from the date of issuance for a period of five years from the date of issuance. All units were purchased by accredited or institutional 
investors under three closings; first closing of 6,795,572 units on February 22, 2012, second closing of 2,032,937 units on February 28, 2012 and 
a third closing of 649,045 units on March 7, 2012.  

F- 18 

   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Craig-Hallum Capital Group LLC acted as the lead placement agent, and Emergent Financial Group, Inc. and Maxim Group LLC served 

as co-placement agents in this transaction and received, in the aggregate, commissions of $450,245, plus reimbursement of out-of-pocket 
expenses of $43,530, and 248,375 warrants to purchase shares of the Company’s common stock at an exercise price of $0.69 per share. The 
warrants have terms identical to the warrants issued to the investors in the February 2012 Private Placement. The fair value of the warrants 
issued to the placement agents of $152,579 was based on Black-Scholes and was recorded to additional paid-in capital and offset against the 
proceeds of the financing with no net effect on equity. The Company also incurred $103,542 and $78,480 of issuance costs including legal, 
accounting and printer fees related to this transaction during the years ended March 31, 2013 and 2012, respectively. The placement agent 
expenses and issuance costs have been offset against the proceeds of the financing in additional paid-in capital.  

Because the consummation of the February 2012 Private Placement would have triggered defaults under the Company’s October 2007 
Debentures, prior to the initial close of the February 2012 Private Placement, the Company obtained a waiver from the holders of the October 
2007 Debentures with respect to such defaults and their consent to the February 2012 Private Placement. In consideration for such waiver and 
consent, the Company, at the initial close, issued to the holders of the October 2007 Debentures warrants to purchase an aggregate of 280,000 
shares of the Company’s common stock at an exercise price of $0.69 per share. The warrants have terms identical to the warrants issued to the 
investors in the February 2012 Private Placement. The fair value of the warrants issued to the convertible debenture holders of $156,999 was 
based on Black-Scholes and was recorded to additional paid-in capital and interest expense in the accompanying consolidated statement of 
operations.  

During the year ended March 31, 2012, the Company received cash proceeds of $571,630 from the exercise of warrants to purchase 

742,380 shares of the Company’s common stock at an average exercise price of $0.77 per share.  

During the year ended March 31, 2012, the Company issued 36,090 shares of common stock upon the cashless exercise of a total of 

85,714 warrants at an exercise price of $0.77 per share.  

Warrants  

A summary of the Company’s warrant activity (other than those warrants issued to the Company’s employees, officers, directors and 

related consultants presented in Note 11 below) and related information during the 2013 fiscal year follows:  

Outstanding at April 1, 2012 
Granted 
Exercised 
Forfeited 
Expired 
Outstanding at March 31, 2013 
Exercisable 

  Number of Shares     
36,831,648     $ 
30,000     $ 
—    $ 
(123,376 )   $ 
(23,929 )   $ 
36,714,343     $ 
36,711,843     $ 

Weighted-  
Average  
Exercise Price     
1.12       
0.50       
—      
0.77       
8.89       
1.12       
1.12       

Remaining 
Contractual 
Life (Years)     

Aggregate  
Intrinsic Value   

2.92     $ 
2.92     $ 

600   
600   

The following summary information reflects outstanding warrants to purchase shares of the Company’s common stock as of March 31, 

2013 and other related details:  

Year of Grant  
(as of March 31) 
2008 
2009 
2010 
2011 
2012 
2013 

Warrants Outstanding  

   Exercise Price  
  $ 
  $ 
  $ 
  $ 
  $ 
  $ 

3.30       
2.81 – $  8.50       
1.91 – $  5.10       
0.77 – $  2.43       
0.69 – $  1.38       
0.50       

Number  
Outstanding  

Remaining  
Contractual  
Life (Years)  

1,728,326       
659,883       
2,769,219       
21,465,729       
10,061,186       
30,000       
36,714,343       

1.75   
1.60   
1.80   
2.73   
3.90   
1.07   

F- 19 

   
   
   
   
   
   
   
   
   
   
  
  
    
        
    
    
        
    
    
        
    
    
        
    
    
        
    
    
    
  
  
  
    
  
  
  
    
        
    
Note 11. Stock Compensation Plan  

Plan Descriptions  

The Company maintains three stock incentive plans, the 2002 Stock Incentive Plan (the “2002 Plan”), the 2009 Stock Incentive Plan (the 

“2009 Plan”) and the 2011 Stock Incentive Plan (the “2011 Plan”). The 2002 Plan provides for grants of incentive stock options and 
nonqualified options to employees, directors and consultants of the Company to purchase the Company’s shares at the fair value, as determined 
by management and the board of directors, of such shares on the grant date. The options are subject to various vesting conditions and generally 
vest over a three-year period beginning on the grant date and have seven to ten-year term. The 2002 Plan also provides for the granting of 
restricted shares of common stock subject to vesting requirements. The Company is authorized to issue up to 500,000 shares under this plan and 
has no shares available for future issuances as the 2002 Plan has expired.  

On October 9, 2009, the Company’s stockholders approved and adopted the 2009 Plan, which had previously been approved by the 
Company’s Board of Directors on August 31, 2009. The 2009 Plan provides for the grant of incentive stock options, nonqualified stock options, 
restricted stock rights, restricted stock, performance share units, performance shares, performance cash awards, stock appreciation rights, and 
stock grant awards (collectively, “Awards”) to employees, officers, non-employee directors, consultants and independent contractors of the 
Company. The 2009 Plan also permits the grant of awards that qualify for the “performance-based compensation” exception to the $1,000,000 
limitation on the deduction of compensation imposed by Section 162(m) of the Internal Revenue Code. A total of 1,200,000 shares of the 
Company’s common stock are authorized for the granting of Awards under the 2009 Plan. The number of shares available for future Awards, as 
well as the terms of outstanding Awards, is subject to adjustment as provided in the 2009 Plan for stock splits, stock dividends, recapitalizations 
and other similar events. Awards may be granted under the 2009 Plan until the sooner of October 9, 2019 or until all shares available for Awards 
under the 2009 Plan have been purchased or acquired. The Company is authorized to issue up to 1,200,000 shares under this plan and as of 
March 31, 2013, the Company has 299,741 shares available for future Awards under the 2009 Plan.  

On September 22, 2011, the Company’s stockholders approved and adopted the 2011 Plan, which had previously been approved by the 

Company’s Board of Directors on July 19, 2011. The 2011 Plan provides for the grant of Awards to employees, officers, non-employee directors 
and consultants of the Company. The Company’s Compensation Committee has the authority to determine the type of Award as well as the 
amount, terms and conditions of each Award under the 2011 Plan, subject to the limitations and other provisions of the 2011 Plan. A total of 
2,300,000 shares of the Company’s common stock are authorized for the granting of Awards under the 2011 Plan. The number of shares 
available for Awards, as well as the terms of outstanding Awards, is subject to adjustment as provided in the 2011 Plan for stock splits, stock 
dividends, recapitalizations and other similar events. Awards may be granted under the 2011 Plan until September 21, 2021 or until all shares 
available for Awards under the 2011 Plan have been purchased or acquired unless the stockholders of the Company vote to approve an extension 
of the 2011 Plan prior to such expiration date. As of March 31, 2013, the Company has 2,240,418 shares available for future Awards under the 
2011 Plan.  

In addition to the stock options issued pursuant to the Company’s three stock incentive plans, the Company has granted warrants to 

employees, officers, non-employee directors, consultants and independent contractors. The warrants are generally not subject to vesting 
requirements and have ten-year terms.  

On November 5, 2012, the Company’s board of directors appointed Jerrell W. Shelton to serve as our President and Chief Executive 
Officer, effective as of November 5, 2012. In connection with Mr. Shelton’s appointment as our President and Chief Executive Officer, the 
Company entered into an employment agreement with Mr. Shelton, which the parties executed on November 5, 2012. Included in the agreement 
was a stock option grant of 1,650,000 options to purchase common stock of which 650,000 were issued under the 2011 stock option plan and 
1,000,000 were issued outside of a plan. The fair value of the options granted under the plan was $109,980 and the fair value of options granted 
outside of a plan was $169,200. The options vest monthly over six months in equal six month installments.  

As of March 31, 2013, a total of 149,537, 886,623 and 3,059,582 shares of common stock were reserved for issuance upon exercise of 
outstanding stock options under the 2002, 2009 and 2011 Plans, respectively, 1,000,000 were issued outside of a Plan and a total of 312,855 
shares of common stock were reserved for issuance upon exercise of outstanding warrants. A summary of the Company’s employee and director 
stock option and warrant activity and related information during the 2013 fiscal year follows:  

Outstanding at April 1, 2012 
Granted 
Exercised 
Canceled 
Outstanding and expected to vest at March 31, 2013 
Exercisable at March 31, 2013 

F- 20 

Number of  
Shares  

Weighted-   
Average  
Exercise  Price     
2.48       
0.29       
—      
0.98       
0.93       
1.14       

1,667,988     $ 
4,063,109     $ 
—    $ 
(322,500 )   $ 
5,408,597     $ 
3,857,129     $ 

Remaining  
Contractual Life     

Aggregate  
Intrinsic Value   

8.48     $ 
8.12     $ 

955,778   
688,397   

   
   
   
   
   
   
   
   
   
   
  
  
  
    
    
        
    
    
        
    
    
        
    
    
        
    
    
    
 The following summary information reflects stock options and warrants outstanding, vesting and related details as of March 31, 2013:  

Year of Grant  
(as of March 31) 
2004 

2005 

2007 

2008 

2009 

2010 

2011 

2012 

2013 

  Exercise Price     
$ 6.00 
$ 0.40 –
 $6.00 
$ 2.80 –
 $10.00 
$ 7.50 –
 $10.80 
$ 5.10 –
 $10.50 
$ 4.30 –
 $8.30 
$ 0.66 –
 $1.89 
$ 0.86 –
 $1.45 
$ 0.17 –
 $0.62 

     Stock Options and Warrants Outstanding    
Remaining  
Contractual  
Life (Years)     
0.50       

Number  
Outstanding     
20,000       

Vested and  
Exercisable    
20,000   

22,200       

1.34       

22,200   

111,335       

3.44       

111,335   

88,780       

4.76       

88,780   

91,740       

2.87       

91,105   

101,601       

4.06       

101,601   

754,832       

6.30       

754,832   

165,000       

8.30       

60,000   

4,053,109       
5,408,597       

9.43       

2,607,276   
3,857,129   

The Company uses Black-Scholes to recognize the value of stock-based compensation expense for all stock-based payment awards. 

Determining the appropriate fair-value model and calculating the fair value of stock-based awards at the grant date requires considerable 
judgment, including estimating stock price volatility, expected option life and forfeiture rates. The Company develops estimates based on 
historical data and market information, which can change significantly over time. Black-Scholes requires the Company to make several key 
judgments including:  

• 

• 

• 

• 

• 

the expected option term reflects the application of the simplified method set out in Staff Accounting Bulletin No. 107 Share-Based 
Payment (SAB 107), which was issued in March 2005. In December 2007, the SEC released SAB 110, which extends the use of the 
“simplified” method, under certain circumstances, in developing an estimate of expected term of “plain vanilla” share options. 
Accordingly, the Company has utilized the average of the contractual term of the options and the weighted average vesting period 
for all options and warrants to calculate the expected option term. 

estimated volatility also reflects the historical volatility pattern of the Company’s share price. 

the dividend yield is based on the Company’s historical pattern of dividends as well as expected dividend patterns. 

the risk-free rate is based on the implied yield of U.S. Treasury notes as of the grant date with a remaining term approximately equal 
to the expected term. 

estimated forfeiture rate of 0% per year is based on the Company’s historical forfeiture activity of unvested stock options. The 
Company used the following assumptions for stock options and warrants granted during the years ended March 31, 2013 and 2012: 

Risk-free interest rate 
Expected volatility 
Expected life (in years) 
Expected dividend yield 

Years Ended March 31,  

2013 
0.63% – 2.22% 
124% – 166% 
2.57 – 10.00 
N/A 

2012 
1.15% – 2.87% 
164% – 173% 
5.91 – 7.44 
N/A 

For the years ended March 31, 2013 and 2012, the weighted-average fair value of the Company’s stock option and warrant grants are as 

follows:  

Grant Year 
March 31, 2013 
March 31, 2012 

Weighted  
Average  
Fair Value of  
Options 

0.26   
1.24   

Granted 

4,063,109     $ 
450,000     $ 

   
   
   
   
   
   
   
   
   
   
   
   
  
  
    
  
      
  
      
  
      
  
      
  
      
  
      
  
      
  
      
  
      
  
    
  
      
        
  
  
  
  
  
      
  
  
      
  
  
      
  
  
      
  
  
      
  
  
    
  
    
    
F- 21 

There were 4,063,109 stock options granted to employees and directors during the year ended March 31, 2013, and 450,000 stock options 

granted to employees and directors during the year ended March 31, 2012. In connection with the options granted and the vesting of prior 
options and warrants issued to employees and directors, during the years ended March 31, 2013 and 2012, the Company recorded total charges 
of $675,439 and $262,844, respectively, which have been included in selling, general and administrative expenses in the accompanying 
consolidated statements of operations. The Company issues new shares from its authorized shares upon exercise of warrants or options.  

As of March 31, 2013, there was $425,086 of total unrecognized compensation cost, related to non-vested stock options, which is expected 

to be recognized over a remaining weighted average vesting period of 1.94 years.  

There were no employee or director stock options and warrants exercised during the years ended March 31, 2013 and 2012.  

Note 12. Equity Instruments Issued to Non-Employees for Acquiring Goods or Services  

During April 2012, the Company issued a warrant to purchase 30,000 shares of the Company’s common stock at an exercise price of $0.50 

per share and a two year life to a consultant for services rendered. The Company recognized $8,546 in expense related to this warrant for the 
year ended March 31, 2013.  

During December 2011, the Company issued a warrant to purchase 155,844 shares of the Company’s common stock at an exercise price of 

$0.77 per share and a five year life to a consultant for services to be rendered over two years. The consultant terminated his services in May 
2012. The Company recognized $8,084 and $16,112 in expense related to this warrant for the years ended March 31, 2013 and 2012, 
respectively.  

During July 2011, the Company issued a warrant to purchase 10,000 shares of the Company’s common stock at an exercise price of $1.20 

per share and a five year life to a consultant for services to be rendered within one year. The Company recognized $8,297 in expense related to 
this warrant for the year ended March 31, 2012.  

During April 2011, the Company issued a warrant to purchase 2,500 shares of the Company’s common stock at an exercise price of $1.38 
per share and a five year life to a consultant for services to be rendered over three years. The Company recognized $1,111 and $966 in expense 
related to this warrant for the years ended March 31, 2013 and 2012, respectively.  

On March 7, 2011, the Company entered into an Advisory Services Agreement with Marc Grossman M.D. to provide strategic business 

advice for which he was issued a fully-vested warrant to purchase 200,000 shares of the Company’s common stock at an exercise price of $0.77 
per share and five year life, in addition to a fee of $125,000. The fair value of this warrant was $302,769 as calculated using Black-Scholes and 
was recorded as an other current asset. For the years ended March 31, 2013 and 2012, the Company recognized $0 and $277,538, respectively, in 
expense related to this warrant and is included in selling, general and administrative in the accompanying consolidated statements of operations.  

Note 13. Commitments and Contingencies  

Lease Commitments  

We currently lease two facilities, with approximately 11,900 square feet of corporate, research and development, and warehouse facilities, 

located in Lake Forest, California (“Lake Forest Facility”) and approximately 4,100 square feet of corporate facilities located in San Diego, 
California (“San Diego Facility”). In June 2010, the Company entered into a third amendment to the Lake Forest Facility lease and extended the 
lease for sixty months commencing July 1, 2010 with a right to cancel the lease with a minimum of 120 day written notice at any time after 
December 31, 2012 and adjusted the base lease payments to a range over the life of the agreement of $7,010 per month to $8,911 per month, plus 
operating expenses. On April 11, 2011, the Company entered into an office service agreement with Regis Management Group, LLC (Lessor) for 
six (6) executive offices in San Diego which the Company terminated effective December 31, 2011. Aggregate base lease payments for these 
offices were approximately $9,250 per month. On November 28, 2011, the Company entered into a lease agreement for the San Diego Facility 
for a thirty six month period ending December 31, 2014. Base lease payments range over the life of the agreement of $8,621 per month to $9,442 
per month, plus operating expenses.  

Total rental expense was approximately $204,000 and $235,000 for the years ended March 31, 2013 and 2012, respectively.  

Future annual minimum payments under operating leases are as follows:  

Years Ending March 31:  
2014 
2015 
2016 
2017 
2018 

  $ 

  $ 

212,949   
192,966   
26,733   
—  
—  
432,648   

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
    
    
    
    
  
F- 22 

Consulting and Engineering Services  

Effective November 1, 2010, the Company entered into a Second Amendment to Master Consulting and Engineering Services Agreement 

(the “Second Amendment”) with KLATU Networks, LLC (“KLATU”), which amended the Master Consulting and Engineering Services 
Agreement between the parties dated as of October 9, 2007 (the “Agreement”), as amended by the First Amendment to Master Consulting and 
Engineering Services Agreement between the parties dated as of April 23, 2009. The parties entered into the Second Amendment to clarify their 
mutual intent and understanding that all license rights granted to the Company under the Agreement, as amended, shall survive any termination 
or expiration of the Agreement. In addition, in recognition that the Company has paid KLATU less than the market rate for comparable services, 
the Second Amendment provides that if the Company terminates the Agreement without cause, which the Company has no intention of doing, or 
liquidates, KLATU shall be entitled to receive additional consideration for its services provided from the commencement of the Agreement 
through such date of termination, which additional compensation shall not be less than $2 million plus two times the “cost of work” (as defined 
in the Agreement). Any such additional compensation would be payable in three equal installments within 12 months following the date the 
amount of such additional compensation is determined. If KLATU terminates that agreement, no such payments are payable.  

The agreement provides for one year terms ending on December 31 of each year, but it automatically renews for one year periods unless 
otherwise terminated. Consulting fees for services provided by KLATU were $401,142 and $494,408 for the years ended March 31, 2013 and 
2012, respectively.  

Litigation  

The Company may become a party to product litigation in the normal course of business. The Company accrues for open claims based on 
its historical experience and available insurance coverage. In the opinion of management, there are no legal matters involving the Company that 
would have a material adverse effect upon the Company’s financial condition or results of operations.  

Indemnities and Guarantees  

The Company has made certain indemnities and guarantees, under which it may be required to make payments to a guaranteed or 
indemnified party, in relation to certain actions or transactions. The guarantees and indemnities do not provide for any limitation of the 
maximum potential future payments the Company could be obligated to make. Historically, the Company has not been obligated nor incurred 
any payments for these obligations and, therefore, no liabilities have been recorded for these indemnities and guarantees in the accompanying 
consolidated balance sheets.  

The Company indemnifies its directors, officers, employees and agents, as permitted under the laws of the States of California and 
Nevada. In connection with its facility leases, the Company has indemnified its lessors for certain claims arising from the use of the facilities. 
The duration of the guarantees and indemnities varies, and is generally tied to the life of the agreement.  

Note 14. Income Taxes  

Significant components of the Company’s deferred tax assets as of March 31, 2013 and 2012 are shown below:  

Deferred tax asset: 

Net operating loss carryforward 
Research credits 
Expenses recognized for granting of options and warrants 
Accrued expenses and reserves 
Valuation allowance 

F- 23 

2013  

2012  

51,000       
1,319,000       
32,000       

  $  13,505,000     $  11,536,000   
32,000   
1,046,000   
(25,000 ) 
     (14,907,000 )      (12,589,000 ) 
—  
—    $ 
  $ 

   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
    
  
    
        
    
    
    
    
  
Based on the weight of available evidence, the Company’s management has determined that it is more likely than not that the net deferred 

tax assets will not be realized. Therefore, the Company has recorded a full valuation allowance against the net deferred tax assets. The 
Company’s income tax provision consists of state minimum taxes.  

The income tax provision differs from that computed using the federal statutory rate applied to income before taxes as follows:  

Computed tax benefit at federal statutory rate 
State tax, net of federal benefit 
Warrant MTM Adjustment 
Interest Expense 
Permanent items and other 
Valuation allowance 

2013 
(2,169,000 )   $ 
(359,000 )     
(6,000 )     
1,000       
215,600       
2,319,000       
1,600     $ 

2012 
(2,662,000 ) 
(426,000 ) 
(41,000 ) 
163,000   
35,600   
2,932,000   
1,600   

  $ 

  $ 

At March 31, 2013, the Company has federal and state net operating loss carryforwards of approximately $34,244,000 and $31,907,000 

which will begin to expire in 2020, unless previously utilized, and as of 2012 have already begun to for state carryforwards. At March 31, 2013, 
the Company has federal and California research and development tax credits of approximately $18,000 and $51,000, respectively. The federal 
research tax credit begins to expire in 2026 unless previously utilized and the California research tax credit has no expiration date.  

Utilization of the net operating loss and research and development carryforwards might be subject to a substantial annual limitation due to 
ownership change limitations that may have occurred or that could occur in the future, as required by Section 382 of the Internal Revenue Code 
of 1986, as amended (the “Code”), as well as similar state and foreign provisions. These ownership changes may limit the amount of NOL and 
R&D credit carryforwards that can be utilized annually to offset future taxable income and tax, respectively. In general, an “ownership change” 
as defined by Section 382 of the Code results from a transaction or series of transactions over a three-year period resulting in an ownership 
change of more than 50 percentage points of the outstanding stock of a company by certain stockholders or public groups. Since the Company’s 
formation, the Company has raised capital through the issuance of capital stock on several occasions which, combined with the purchasing 
stockholders’ subsequent disposition of those shares, may have resulted in such an ownership change, or could result in an ownership change in 
the future upon subsequent disposition.  

The Company has not completed a study to assess whether an ownership change has occurred. If the Company has experienced an 
ownership change, utilization of the NOL or R&D credit carryforwards would be subject to an annual limitation under Section 382 of the Code, 
which is determined by first multiplying the value of the Company’s stock at the time of the ownership change by the applicable long-term, tax-
exempt rate, and then could be subject to additional adjustments, as required. Any limitation may result in expiration of a portion of the NOL or 
R&D credit carryforwards before utilization. Further, until a study is completed and any limitation is known, no amounts are being considered as 
an uncertain tax position or disclosed as an unrecognized tax benefit. Due to the existence of the valuation allowance, future changes in the 
Company’s unrecognized tax benefits will not impact its effective tax rate. Any carryforwards that will expire prior to utilization as a result of 
such limitations will be removed from deferred tax assets with a corresponding reduction of the valuation allowance.  

F- 24 

   
   
   
   
   
   
   
  
  
  
    
  
    
    
    
    
    
  
Note 15. Quarterly Results of Operations (unaudited)  

The following table sets forth a summary of our unaudited quarterly operating results for each of the last eight quarters in the period ended 

March 31, 2013. This data has been derived from our unaudited consolidated interim financial statements which, in our opinion, have been 
prepared on substantially the same basis as the audited consolidated financial statements contained elsewhere in this report and include all 
normal recurring adjustments necessary for a fair presentation of the financial information for the periods presented. These unaudited quarterly 
results should be read in conjunction with our consolidated financial statements and notes thereto included elsewhere in this report. The 
operating results in any quarter are not necessarily indicative of the results that may be expected for any future period (in thousands except 
earnings per share).  

Mar. 31,  
2013 

Dec. 31,  
2012 

Sept. 30,  
2012 

June 30,  
2012 

Mar. 31,  
2012 

Dec. 31,  
2011 

Sept. 30,  
2011 

June 30,  
2011 

Quarter Ended 

  $ 

Revenues: 
Cost of revenues 
Gross loss 
Research and development 
Selling, general and 
administrative 

Total operating expenses 
Loss from operations 
Other (expense) income, net     
Loss before income taxes 
Income taxes 
Net loss 
  $ 
Net loss per common share:      

Basic and diluted 

Weighted average common 
shares outstanding: 

Basic 
Diluted 

Note 16. Subsequent Events  

368     $ 
521       
(153 )     
120       

1,408       
1,528       
(1,681 )     
(36 )     
(1,717 )     
—      
(1,717 )   $ 

307     $ 
369       
(62 )     
94       

1,393       
1,487       
(1,549 )     
(18 )     
(1,567 )     
—      
(1,567 )   $ 

234     $ 
345       
(111 )     
102       

1,341       
1,443       
(1,554 )     
3      
(1,551 )     
2       
(1,553 )   $ 

unaudited 
191     $ 
354       
(163 )     
109       

1,269       
1,378       
(1,541 )     
(5 )     
(1,546 )     
—      
(1,546 )   $ 

177     $ 
330       
(153 )     
145       

1,173       
1,318       
(1,471 )     
(198 )     
(1,669 )     
—      
(1,669 )   $ 

144     $ 
345       
(201 )     
121       

1,740       
1,861       
(2,062 )     
(18 )     
(2,080 )     
—      
(2,080 )   $ 

111     $ 
364       
(253 )     
125       

1,564       
1,689       
(1,942 )     
(88 )     
(2,030 )     
—      
(2,030 )   $ 

124   
355   
(231 ) 
101   

1,628   
1,729   
(1,960 ) 
(92 ) 
(2,052 ) 
2   
(2,054 ) 

(0.05 )     

(0.04 )     

(0.04 )     

(0.04 )     

(0.06 )     

(0.07 )     

(0.07 )     

(0.07 ) 

37,761       
37,761       

37,761       
37,761       

37,761       
37,761       

37,761       
37,761       

32,014       
32,014       

28,247       
28,247       

27,967       
27,967       

27,690   
27,690   

In the first quarter of fiscal year 2014, the Company issued to certain accredited investors an additional $608,751 in Bridge Notes with the 
same terms as described under Note 8. These additional Bridge Notes include $100,000 from one of our Board Members, Richard Rathmann. As 
of June 17, 2013 the total principal amount of the Bridge Notes was $1,903,251.  

In May 2013, the Company issued 500,000 shares of common stock upon the exercise of options at an exercise price of $0.20 per share for 

total gross proceeds of $100,000.  

F- 25 

   
   
   
   
   
   
   
  
  
  
  
  
  
    
    
    
    
    
    
    
  
  
    
      
      
    
      
      
      
  
    
    
    
    
    
    
    
    
        
        
        
        
        
        
        
    
    
    
        
        
        
        
        
        
        
    
    
    
SIGNATURES  

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to 

be signed on its behalf by the undersigned, thereunto duly authorized.  

Dated: June 25, 2013 

CRYOPORT, INC. 

By: 

/S/ JERRELL W. SHELTON  
Jerrell W. Shelton 

   Chief Executive Officer and 
   Director 

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the 
Registrant and in the capacities and on the dates indicated:  

Signature  

Title  

Date  

/s/ JERRELL W. SHELTON  

   Chief Executive Officer and Director (Principal Executive 

June 25, 2013 

Jerrell W. Shelton 

Officer) 

/s/ ROBERT S. STEFANOVICH  

   Chief Financial Officer (Principal Financial and Accounting 

June 25, 2013 

Robert S. Stefanovich 

/s/ ADAM M. MICHELIN   
Adam M. Michelin 

/s/ KAREN M. MULLER   
Karen M. Muller 

/s/ RICHARD G. RATHMANN   
Richard G. Rathmann 

/s/ STEPHEN E. WASSERMAN  
Stephen E. Wasserman 

Officer) 

   Director 

   Director 

   Director 

   Director 

38 

June 25, 2013 

June 25, 2013 

June 25, 2013 

June 25, 2013 

   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
   
  
   
  
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Exhibit No.    

3.1 

3.2 

3.3 

EXHIBIT INDEX    

Description    

   Amended and Restated Articles of Incorporation of the Company, as amended.  Incorporated by reference to Exhibit 3.1 to 

the Company’s Quarterly Report on Form 10-Q for the Quarter Ended September 30, 2012. 

   Amended and Restated Bylaws of the Company.  Incorporated by reference to Exhibit 3.2 of the Company’s Current Report 

on Form 8-K dated October 23, 2012. 

   Cryoport Systems, Inc. 2002 Stock Incentive Plan adopted by the Board of Directors on October 1, 2002.  Incorporated by 

reference to Exhibit 3.13 to the Company’s Registration Statement on Form 10-SB/A2 dated January 26, 2006. 

4.1.1 

   Form of Debenture—Original Issue Discount 8% Secured Convertible Debenture dated September 28, 2007. Incorporated 

by reference to Cryoport’s Registration Statement on Form SB-2 dated November 9, 2007. 

4.1.2 

   Amendment to Convertible Debenture dated February 19, 2008. Incorporated by reference to Cryoport’s Current Report on 

Form 8-K dated March 7, 2008 and referred to as Exhibit 10.1.10. 

4.1.3 

   Amendment to Convertible Debenture dated April 30, 2008. Incorporated by reference to Cryoport’s Current Report on 

Form 8-K dated April 30, 2008 and referred to as Exhibit 10.1.11. 

4.1.4 

   Annex to Amendment to Convertible Debenture dated April 30, 2008. Incorporated by reference to Cryoport’s Current 

Report on Form 8-K dated April 30, 2008 and referred to as Exhibit 10.1.11.1. 

4.1.5 

   Amendment to Convertible Debenture dated August 29, 2008. Incorporated by reference to Cryoport’s Current Report on 

Form 8-K dated August 29, 2008. 

4.1.6 

   Amendment to Convertible Debenture effective January 27, 2009 and dated February 20, 2009. Incorporated by reference to 

Cryoport’s Current Report on Form 8-K dated February 19, 2009. 

4.1.7 

   Amendment to Debentures and Warrants with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce 

Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and Cryoport Inc. dated September 1, 2009. 
Incorporated by reference to Cryoport’s Current Report on Form 8-K dated September 17, 2009. 

4.1.8 

   Amendment to Debentures and Warrants, Agreement and Waiver with Enable Growth Partners LP, Enable Opportunity 
Partners LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and Cryoport Inc. dated 
January 12, 2010. Incorporated by reference to Cryoport’s Current Report on Form 8-K dated January 15, 2010. 

4.1.9 

   Amendment Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified Strategy 

Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and Cryoport Inc. dated February 1, 2010. Incorporated by reference 
to Cryoport’s Current Report on Form 8-K dated February 3, 2010. 

4.1.10 

   Amended and Restated Amendment Agreements with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce 

Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and Cryoport Inc. dated  
February 19, 2010. Incorporated by reference to Cryoport’s Current Report on Form 8-K dated February 26, 2010. 

4.1.11 

   First Amendment to Amended and Restated Amendment Agreements with Enable Growth Partners LP, Enable Opportunity 
Partners LP, Pierce Diversified Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and Cryoport Inc. dated 
February 23, 2010. Incorporated by reference to Cryoport’s Current Report on Form 8-K dated February 26, 2010. 

4.2 

   Form of Common Stock Purchase Warrant dated September 28, 2007. Incorporated by reference to Cryoport’s Registration 

Statement on Form SB-2 dated November 9, 2007. 

39 

   
   
     
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Exhibit No. 

Description 

4.3 

4.4 

4.5 

4.6 

4.7 

4.8 

4.9 

4.10 

4.11 

4.12 

4.13 

4.14 

4.15 

4.16 

4.17 

4.18 

4.19 

   Original Issue Discount 8% Secured Convertible Debenture dated May 30, 2008. Incorporated by reference to Cryoport’s 

Current Report on Form 8-K dated June 9, 2008. 

   Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to Cryoport’s Current Report on Form 8-

K dated June 9, 2008 

   Common Stock Purchase Warrant dated May 30, 2008. Incorporated by reference to Cryoport’s Current Report on Form 8-

K dated June 9, 2008 

   Form of Warrant and Warrant Certificate in connection with the February 25, 2010 public offering. Incorporated by 

reference to Cryoport’s Amendment No. 5 to Form S-1/A Registration Statement dated February 9, 2010. 

   Form of Securities Purchase Agreement in connection with the August to October 2010 private placement. Incorporated by 

reference to Cryoport’s Registration Statement on Form S-1 dated October 19, 2010. 

   Form of First Amendment to Security Purchase Agreement in connection with the August to October 2010 private 
placement. Incorporated by reference to Cryoport’s Registration Statement on Form S-1 dated October 19, 2010. 

   Form of Securities Purchase Agreement (Continuation of the Placement) in connection with the August to October 2010 

private placement. Incorporated by reference to Cryoport’s Registration Statement on Form S-1 dated  
October 19, 2010. 

   Registration Rights Agreement in connection with the August to October 2010 private placement. Incorporated by reference 

to Cryoport’s Registration Statement on Form S-1 dated October 19, 2010. 

   Form of Joinder to Registration Rights Agreement in connection with the August to October 2010 private placement. 

Incorporated by reference to Cryoport’s Registration Statement on Form S-1 dated October 19, 2010. 

   Form of Securities Purchase Agreement in connection with the February 2011 private placement. Incorporated by reference 

to Cryoport’s Registration Statement on Form S-1 dated April 1, 2011. 

   Form of Registration Rights Agreement in connection with the February 2011 private placement. Incorporated by reference 

to Cryoport’s Registration Statement on Form S-1 dated April 1, 2011. 

   Form of Warrant in connection with the August to October 2010 private placement. Incorporated by reference to Cryoport’s 

Registration Statement on Form S-1/A dated April 22, 2011. 

   Form of Warrant in connection with the February 2011 private placement. Incorporated by reference to Cryoport’s 

Registration Statement on Form S-1/A dated April 22, 2011. 

   Form of Securities Purchase Agreement. Incorporated by reference to Cryoport’s Current Report of Form 8-K filed with the 

SEC on February 24, 2012. 

   Form of Registration Rights Agreement. Incorporated by reference to Cryoport’s Current Report of Form 8-K filed with the 

SEC on February 24, 2012. 

   Form of Warrant. Incorporated by reference to Cryoport’s Current Report of Form 8-K filed with the SEC on February 24, 

2012. 

   Warrant issued to Rodman & Renshaw, LLC in connection with the February 25, 2010 public offering. Incorporated by 

reference to CryoPort’s Registration Statement on Form S-1 dated October 19, 2010. 

10.1.1 

   Commercial Promissory Note between Cryoport, Inc. and D. Petreccia executed on August 26, 2005. Incorporated by 

reference to Cryoport’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

10.1.2 

   Commercial Promissory Note between Cryoport, Inc. and J. Dell executed on September 1, 2005. Incorporated by reference 

to Cryoport’s Registration Statement on Form 10-SB/A4 dated February 23, 2006.  

10.1.3 

   Commercial Promissory Note between Cryoport, Inc. and P. Mullens executed on September 2, 2005. Incorporated by 

reference to Cryoport’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

10.1.4 

   Commercial Promissory Note between Cryoport, Inc. and R. Takahashi executed on August 25, 2005. Incorporated by 

reference to Cryoport’s Registration Statement on Form 10-SB/A4 dated February 23, 2006. 

    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
40 

   
Exhibit No. 

10.5.1 

10.5.2 

10.5.3 

10.6 

10.7 

10.9 

Description 

   Lease Agreement dated June 26, 2007 between CryoPort, Inc. and Viking Investors—Barents Sea LLC. Incorporated by 
reference to Cryoport’s Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007 and referred to as Exhibit 
10.5. 

   Second Amendment To Lease: Renewal dated August 24, 2009, between CryoPort, Inc. and Viking Inventors-Barents Sea 
LLC. Incorporated by reference to Cryoport’s Amendment No. 1 to Form S-1/A Registration Statement dated January 12, 
2010. 

   Third Amendment to Lease: Renewal dated June 8, 2010 between Viking Investors Barents Sea, LLC.*  

   Securities Purchase Agreement dated September 27, 2007. Incorporated by reference to Cryoport’s Registration Statement 

on Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.6. 

   Registration Rights Agreement dated September 27, 2007. Incorporated by reference to Cryoport’s Registration Statement 

on Form SB-2 dated November 9, 2007 and referred to as Exhibit 10.7. 

   Security Agreement dated September 27, 2007. Incorporated by reference to Cryoport’s Registration Statement on Form SB-

2 dated November 9, 2007 and referred to as Exhibit 10.8. 

10.10 

   Securities Purchase Agreement dated May 30, 2008. Incorporated by reference to Cryoport’s Current Report on Form 8-K 

dated June 9, 2008 and referred to as Exhibit 10.10. 

10.11 

   Registration Rights Agreement dated May 30, 2008. Incorporated by reference to Cryoport’s Current Report on Form 8-K 

dated June 9, 2008 and referred to as Exhibit 10.11. 

10.12 

   Waiver dated May 30, 2008. Incorporated by reference to Cryoport’s Current Report on Form 8-K dated June 9, 2008 and 

referred to as Exhibit 10.12. 

10.13 

   Security Agreement dated May 30, 2008. Incorporated by reference to Cryoport’s Current Report on Form 8-K dated June 9, 

2008 and referred to as Exhibit 10.13. 

41 

   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Exhibit No. 

Description 

10.14 

   Consent, Waiver and Agreement with Enable Growth Partners LP, Enable Opportunity Partners LP, Pierce Diversified 

Strategy Master Fund LLC, Ena, BridgePointe Master Fund Ltd. and Cryoport Inc. and its subsidiary dated July 30, 2009. 
Incorporated by reference to Cryoport’s Current Report on Form 8-K dated July 29, 2009 and referred to as Exhibit 10.15. 

10.15.1 

10.15.2 

   Master Consulting and Engineering Services Agreement dated October 9, 2007 with KLATU Networks, LLC and CryoPort, 
Inc. Incorporated by reference to Cryoport, Inc.’s Registration Statement on Form S-8 dated March 25, 2009 and referred to 
as Exhibit 10.2. 

   First Amendment to Master Consulting and Engineering Services Agreement dated as of April 23, 2009, between CryoPort, 
Inc. and KLATU Networks, LLC. Incorporated by reference to Cryoport’s Registration Statement on Form S-1/A dated 
December 17, 2010 and referred to as Exhibit 10.32. 

10.15.3 

   Second Amendment to Master Consulting and Engineering Services Agreement dated as of November 1, 2010, between 

CryoPort, Inc. and KLATU Networks, LLC. Incorporated by reference to Cryoport’s Registration Statement on Form S-1/A 
dated December 17, 2010 and referred to as Exhibit 10.33. 

10.16 

   Stock Option Agreement ISO under the 2002 Stock Incentive Plan of Cryoport Systems, Inc. Incorporated by reference to 

Exhibit 3.14 to the Company’s Registration Statement on Form 10-SB/A2 dated January 26, 2006. 

10.17 

   Stock Option Agreement NSO under the 2002 Stock Incentive Plan of Cryoport Systems, Inc. Incorporated by reference to 

Exhibit 3.15 to the Company’s Registration Statement on Form 10-SB/A2 dated January 26, 2006. 

10.18 

   2009 Stock Incentive Plan of the Company.  Incorporated by reference to Exhibit 10.21 of the Company’s Current Report on 

Form 8-K dated October 9, 2009 and referred to as Exhibit 10.21. 

10.19 

   Form Incentive Stock Option Award Agreement under the 2009 Stock Incentive Plan of the Company. Incorporated by 

reference to Exhibit 10.22 of the Company’s Current Report on Form 8-K dated October 9, 2009. 

10.20 

   Form of Non-Qualified Stock Option Award Agreement under the 2009 Stock Incentive Plan of the Company. Incorporated 

by reference to Exhibit 10.25 of the Company’s Registration Statement on Form S-8 dated April 27, 2010. 

10.21 

   2011 Stock Incentive Plan (as amended and restated).  Incorporated by reference to Exhibit B of the Company’s Definitive 

Proxy Statement on Schedule 14A filed with the SEC on July 30, 2012. 

10.22 

   Form of Stock Option Award Agreement. Incorporated by reference to Exhibit 10.37 to Registrant’s Current Report on 

Form 8-K filed with the SEC on September 27, 2011. 

10.23 

   Form of Non-Qualified Stock Option Award Agreement. Incorporated by reference to Exhibit 10.38 to Registrant’s Current 

Report on Form 8-K filed with the SEC on September 27, 2011. 

10.24 

10.25 

10.26 

   Form of Convertible Promissory Note.* 

   Form of Amendment to Convertible Promissory Note.* 

   Form of Convertible Promissory Note.* 

42 

   
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Exhibit No. 

Description 

10.27 

10.28 

10.29 

21 

23.1 

31.1 

31.2 

32.1 

32.2 

Employment Agreement between the Company and Jerrell Shelton.  Incorporated by reference to the Company’s Current 
Report on Form 8-K filed on November 6, 2012 and referred to as Exhibit 10.45. 

Stock Option Agreement dated November 5, 2012 between the Company and Jerrell Shelton.* 

Master Agreement between the Company and Federal Express Corporation dated January 1, 2013.**  Incorporated by 
reference to the Company’s Current Report on Form 8-K filed on January 8, 2013 and referred to as Exhibit 10.1. 

   Subsidiaries of Registrant* 

   Consent of Independent Registered Public Accounting Firm—KMJ Corbin & Company LLP.* 

   Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer.* 

   Rule 13a-14(a)/15d-14(a) Certification of Chief Financial Officer.* 

   Certification Pursuant to U.S.C. §1350 of Chief Executive Officer.* 

   Certification Pursuant to U.S.C. §1350 of Chief Financial Officer.* 

101.INS*** 

   XBRL Instance Document.* 

101.SCH*** 

   XBRL Taxonomy Extension Schema Document.* 

101.CAL*** 

   XBRL Taxonomy Extension Calculation Linkbase Document.* 

101.DEF*** 

   XBRL Taxonomy Extension Definition Linkbase Document.* 

101.LAB*** 

   XBRL Taxonomy Extension Label Linkbase Document.* 

101.PRE*** 

   XBRL Taxonomy Extension Presentation Linkbase Document.* 

Filed herewith 
Portions omitted pursuant to a request for confidential treatment filed separately with the Commission. 

* 
** 
***  Pursuant to applicable securities laws and regulations, we are deemed to have complied with the reporting obligation relating to the 

submission of interactive data files in such exhibits and are not subject to liability under any anti-fraud provisions of the federal securities 
laws as long as we have made a good faith attempt to comply with the submission requirements and promptly amend the interactive data 
files after becoming aware that the interactive data files fail to comply with the submission requirements. Users of this data are advised 
that, pursuant to Rule 406T, these interactive data files are deemed not filed and otherwise are not subject to liability. 

43 

   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
I 

PARTIES 

THIRD AMENDMENT TO LEASE: RENEWAL  

This amendment is executed in Lake Forest, California, on June 8th, 2010, by and between VIKING INVESTROS BARENTS SEA, 
LLC, ("Lessor"}, and CRYOPORT SYSTEMS, INC. ("Lessee''). for the property known as 20382 Barents Sea Circle, Lake Forest, 
California.  

II 

RECITALS 

Lessor and Lessee being parties to that certain lease dated June 26, 2007. attached hereto as Exhibit "A". hereby express their mutual 
desire to extend the lease per the terms and conditions of this Third Amendment To Lease: Renewal.  

Exhibit 10.5.3 

III 

AMENDMENTS 

·'LEASE TERM": The lease term shall be extended for an additional sixty (60) months.  
commencing July 1, 2010 and shall expire June 30, 2015.  

"RENT" shall hereinafter be paid as follows:  

July 1, 2010 - June 30, 201 1: Base rent shall be $7,010 NNN per month.  
July 1. 2011 -June 30. 2012; Base rent shall be $7,247 NNN per month.  
July 1. 2012- June 30, 2013; Base rent shall be $7,604 NNN per month.  
July 1, 2013 - June 30, 2014; Base rent shall be $8,198 NNN per month.  
July 1. 2014 - June 30, 2015; Base rent shall be $8,911 NNN per month.  

In addition to the Base Rent Lessee shall be responsible for additional NNN charges according to the provisions of the original lease. 
The NNN charges shall not increase by more than 2% compounded annually. Furthermore, Lessee shall not be liable to pay an increase 
in property taxes triggered by a possible sale of the property.  

"CANCELLATION CLAUSE": Lessee shall have the right to cancel the lease with a minimum of 120 day written notice at anytime as 
of December 31, 2012. In the event Lessee does exercise its option to cancel the lease. Lessee shall reimburse Lessor of the unearned 
leasing commissions paid to Cresa Partners.  

·'LANDLORD'S OBLIGATION"; Lessor shall be responsible, during the initial term and any extensions thereto, for all capital repairs 
or replacements (as defined by generally accepted accounting principles) related to the these systems. Any ongoing maintenance 
charges shall be part of the NNN charges payable by Lessee.  

"TENANT IMPROVEMENTS": Lessor shall as soon as reasonably possible steam clean the existing carpet, apply touch-up paint 
where necessary in the office area and Lessor shall repair the moisture seepage problem in the downstairs office area.  

''OPTION TO EXTEND"; Lessee shall have one (1) three (3) year Option to Extend. The extension rental rate and terms shall be at the 
then prevailing market terms and conditions for comparable space in comparable buildings in the vicinity. Lessee shall give Lessor a 
minimum of one hundred eighty (180) days prior written notice.  

  
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
"ASSIGNMENT AND SUBLETTING"; Lessee shall have the right to sublease or assign any portion of the entire space to any 

related entity, parent company, subsidiary or affiliate without Lessor's consent. Lessee shall have the right to sublease or assign any 
portion of the space to any other subtenant with Lessor's written consent, which shall not be unreasonably withheld or delayed. Lessor 
shall have no right to recapture said space and all proceeds attributable to any assignment or sublease shall inure to the benefit of 
Lessee.  

IV 

INCORPORATION 

Except as modified herein, all other terms and conditions of the lease between the parties above described, as attached hereto, shall 
continue in full force and effect.  

In Witness Whereof, Lessor and Lessee have executed this amendment as of the day and year first above written.  

LESSOR: VIKING INVESTORS BARENTS SEA LLC  

/S/ Jan-Erik Palm 
Jan-Erik Palm, Managing Member 

LESSEE: CRYOPORT SYSTEMS, INC.  

By: 

/s/ Bret Bollinger 

Bret Bollinger, VP of Operations 

    
   
   
   
    
   
    
    
    
   
  
  
  
  
  
  
  
THE ISSUANCE OF THIS PROMISSORY NOTE, AND THE SECURITIES INTO WHICH IT IS CONVERTIBLE (COLLECTIVELY, THE 
“ SECURITIES ”), HAVE NOT BEEN REGISTERED WITH THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION OR 
THE  SECURITIES  COMMISSION  OF  ANY  STATE.  THE  SECURITIES  ARE  BEING  OFFERED  PURSUANT  TO  CLAIMED 
EXEMPTIONS  FROM  REGISTRATION  UNDER  REGULATION  D  PROMULGATED  UNDER  THE  SECURITIES  ACT  OF  1933,  AS 
AMENDED  (THE  “  ACT”  ).  THE  SECURITIES  ARE  “  RESTRICTED  SECURITIES  ”  AND  MAY  NOT  BE  OFFERED  OR  RESOLD 
UNLESS THE  SECURITIES  ARE REGISTERED  UNDER  THE ACT, OR  ELIGIBLE TO  BE OFFERED OR  SOLD  PURSUANT TO  AN 
APPLICABLE  EXEMPTION  FROM  SUCH  REGISTRATION  REQUIREMENTS.  THE  COMPANY  MAY  REQUIRE  THAT  IT  BE 
PROVIDED WITH OPINION OF COUNSEL OR OTHER SUCH INFORMATION AS IT MAY REASONABLY REQUIRE TO CONFIRM 
THAT SUCH EXEMPTIONS ARE AVAILABLE. FURTHER, HEDGING TRANSACTIONS INVOLVING THE SECURITIES MAY NOT 
BE MADE EXCEPT IN COMPLIANCE WITH THE ACT.  

Exhibit 10.24 

CRYOPORT, INC.  

US $[________] 

This Promissory Note (the “ Note ”) is issued as of __________, 201_ by CRYOPORT, INC ., a Nevada corporation (the “ Company ”), 
to  _____________________________________  (together  with  its  permitted  successors  and  assigns,  the  “  Holder  ”)  with  an  address 
of_______________________________ pursuant to exemptions from registration under the Securities Act of 1933, as amended.  

ARTICLE I.  

Section 1.01 Principal and Interest . The Company hereby promises to pay the principal sum of US $[________] pursuant to the terms 
hereof and to pay interest to the Holder on such principal balance from the date hereof. From the date hereof until January 31, 2013, interest shall 
accrue at the rate of fifteen percent (15%) per annum and from February 1, 2013 through the date of payment, interest shall accrue at the rate of 
five percent (5%) per annum.  

Section 1.02 Maturity Date . All unpaid principal and accrued interest hereunder shall be paid on December 31, 2013.  

Section 1.03 Optional Conversion to Preferred Stock . The Company is currently in negotiations with prospective investors for the 
issuance by the Company of preferred shares which are contemplated to be convertible into common stock of the Company. The terms of such 
preferred shares have yet to be established and there can be no assurance that such preferred shares will be issued. In the event, however, that the 
Company shall authorize and offer preferred shares while the Note is outstanding, the Company will provide written notice to the Holder of the 
offer of such shares and the Holder shall have the option during the ten days following such notice to elect to convert all or a portion of the 
principal and accrued interest under this Note into the offered shares. The Company shall not issue fractional shares upon a conversion. If the 
application of the Conversion price shall contemplate issuance of less than a half share, such fractional share shall not be issued and no payment 
shall be made to the converting Holder and should such application result in the issuance of a half or greater fractional share, such fractional 
share shall be rounded up to the next full share.  

Section 2.01 No Prepayment . This Note may not be prepaid by the Company without the express written consent of the Holder.  

ARTICLE II.  

   
   
   
   
  
   
   
   
   
   
   
   
  
Section 2.02 Pari Passu With Other Notes . The payment of this Note and other similar notes issued for up to an aggregate principal 
sum of $3,000,000 shall be made in full by the Company and if the Company is unable to fully repay all such notes, then payment shall be on a 
pari passu basis.  

ARTICLE III.  

Section 3.01 Re-issuance of Note . Should the Holder elect to convert a part, but not all, of the unpaid principal amount then owing to 
the Holder under this Note, then the Company shall reissue a new Note in the same form as this Note to reflect the new principal amount and the 
accrued unpaid interest which was not converted.  

Section 3.02 Notices . Notices regarding this Note shall be sent to the parties at the following addresses, unless a party notifies the other 

parties, in writing, of a change of address:  

If to the Holder, to: 

If to the Company: 

Cryoport, Inc. 
20382 Barents Sea Circle 
Lake Forest, CA 92101 

Section 3.03 Governing Law . This Note shall be deemed to be made under and shall be construed in accordance with the laws of the 

state of Nevada without giving effect to the principals of conflict of laws thereof.  

Section 3.04 Severability . The invalidity of any of the provisions of this Note shall not invalidate or otherwise affect any of the other 

provisions of this Note, which shall remain in full force and effect.  

Section 3.05 Entire Agreement and Amendments . This Note represents the entire agreement between the parties hereto with respect 
to the subject matter hereof and there are no representations, warranties or commitments, except as set forth herein. This Note may be amended 
only by an instrument in writing executed by the parties hereto.  

Section 3.06. No Waiver, Cumulative Remedies . No failure to exercise and no delay in exercising, on the part any party, any right, 
remedy, power or privilege hereunder, shall operate as a waiver thereof, nor shall any single or partial exercise of any right, remedy, power or 
privilege  hereunder  preclude  any  other  or  further  exercise  thereof  or  the  exercise  of  any  other  right,  remedy,  power  or  privilege.  The  rights, 
remedies, powers and privileges herein provided are cumulative and not exhaustive of any rights, remedies, powers and privileges provided by 
law.  

Section 3.07 Waiver of Trial by Jury . To the extent permitted by applicable Law, each of the parties irrevocably waives all right of 

trial by jury in any action, proceeding or counterclaim arising out of or in connection with this Note or any matter arising hereunder.  

Section .3.08 Legal Holidays . In any case where the date on which any payment is due to any Holder shall not be a business day, then 
any such payment need not be made on such date, but may be made on the next succeeding business day with the same force and effect as if 
made on the date on which nominally due, and no interest shall accrue for the period from and after any such nominal date.  

   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
IN WITNESS WHEREOF, with the intent to be legally bound hereby, the Company as executed this Note as of the date first written 

above.  

CRYOPORT, INC. 

By: 

a duly authorized officer 

   
   
    
   
  
  
  
  
  
  
  
  
  
  
  
  
  
AMENDMENT TO PROMISSORY NOTE  

Exhibit 10.25 

This  Amendment  to  Promissory  Note  (the  “  Amendment  ”)  amends  that  certain  Promissory  Note  issued  by  CRYOPORT,  INC.,  a 
Nevada corporation (the “ Company ”), dated as of the date, to the holder, and in the original principal amount as set forth on the signature page 
hereto (the “ Note ”).  

For valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:  

1. 

Section 1.03 of the Note is hereby deleted and replaced with the following: 

Section  1.03  Conversion  to  Equity  Options  .  The  Company  is  currently  in  negotiations  with  prospective  investors  for  the 
issuance by the Company of equity securities. These securities may be common stock or preferred stock and may or may not involve 
the issuance of warrants to purchase equity in the Company. The terms of such equity securities have yet to be established and there can 
be no assurance that such equity securities will be issued. In the event, however, that the Company shall issue one or more types of 
equity  securities  (a  “  Transaction  ”)  before  the  maturity  of  this  Note,  the  Company  shall  in  each  event  notify  the  Holder  in  writing 
within ten (10) days of such issuance of the terms of the Transaction and the Holder shall have the option until the later of (a) ten (10) 
days after such notice or (b) December 15, 2013 to elect in writing to convert all or a portion of the principal and accrued interest under 
this Note into the equity securities that were issued by the Company on the same terms that the Company issued said securities in such 
Transaction.  The  Company  shall  not  issue  fractional  shares  upon  a  conversion.  If  the  application  of  the  Conversion  price  shall 
contemplate issuance of less than a half share, such fractional share shall not be issued and no payment shall be made to the converting 
Holder and should such application result in the issuance of a half or greater fractional share, such fractional share shall be rounded up 
to the next full share.  

2.          This Amendment may be executed in any number of counterparts, each of which shall be an original, but all of which together shall 
constitute one instrument. Facsimile and/or other electronically transmitted signatures shall be effective for all purposes.  

3.          Other than as set forth in this Amendment, all of the terms and conditions of the Note shall continue in full force and effect.  

[The remainder of this page has been intentionally left blank.]  

IN WITNESS WHEREOF, the parties hereto have executed this Amendment to Promissory Note as of the date set first set forth above.  

   
   
    
   
   
   
   
   
   
   
   
  
Dated:     

, 2013 

CRYOPORT, INC. 

By:     

a duly authorized officer 

Agreed and acknowledged:  

Signature 

Date of Promissory Note : 

, 2013 

Holder : 

Original Principal Amount : 

   
   
   
   
    
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
THE ISSUANCE OF THIS PROMISSORY NOTE, AND THE SECURITIES INTO WHICH IT IS CONVERTIBLE (COLLECTIVELY, THE 
“ SECURITIES ”), HAVE NOT BEEN REGISTERED WITH THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION OR 
THE  SECURITIES  COMMISSION  OF  ANY  STATE.  THE  SECURITIES  ARE  BEING  OFFERED  PURSUANT  TO  CLAIMED 
EXEMPTIONS  FROM  REGISTRATION  UNDER  REGULATION  D  PROMULGATED  UNDER  THE  SECURITIES  ACT  OF  1933,  AS 
AMENDED  (THE  “  ACT”  ).  THE  SECURITIES  ARE  “  RESTRICTED  SECURITIES  ”  AND  MAY  NOT  BE  OFFERED  OR  RESOLD 
UNLESS THE  SECURITIES  ARE REGISTERED  UNDER  THE ACT, OR  ELIGIBLE TO  BE OFFERED OR  SOLD  PURSUANT TO  AN 
APPLICABLE  EXEMPTION  FROM  SUCH  REGISTRATION  REQUIREMENTS.  THE  COMPANY  MAY  REQUIRE  THAT  IT  BE 
PROVIDED WITH OPINION OF COUNSEL OR OTHER SUCH INFORMATION AS IT MAY REASONABLY REQUIRE TO CONFIRM 
THAT SUCH EXEMPTIONS ARE AVAILABLE. FURTHER, HEDGING TRANSACTIONS INVOLVING THE SECURITIES MAY NOT 
BE MADE EXCEPT IN COMPLIANCE WITH THE ACT.  

Exhibit 10.26 

CRYOPORT, INC.  

US $[________] 

This Promissory Note (the “ Note ”) is issued as of __________ __, 2013 by CRYOPORT, INC ., a Nevada corporation (the “ Company 
”),  to  _____________________________________  (together  with  its  permitted  successors  and  assigns,  the  “  Holder  ”)  with  an  address 
of_______________________________ pursuant to exemptions from registration under the Securities Act of 1933, as amended.  

ARTICLE I.  

Section 1.01 Principal and Interest . The Company hereby promises to pay the principal sum of US $[________] pursuant to the terms 
hereof  and  to  pay  interest  to  the  Holder  on  such  principal  balance  from  the  date  hereof.  From  the  date  hereof  through  the  date  of  payment, 
interest shall accrue at the rate of five percent (5%) per annum.  

Section 1.02 Maturity Date . All unpaid principal and accrued interest hereunder shall be paid on December 31, 2013.  

Section 1.03 Conversion to Equity Options . The Company is currently in negotiations with prospective investors for the issuance by 
the Company of equity securities. These securities may be common stock or preferred stock and may or may not involve the issuance of warrants 
to purchase equity in the Company. The terms of such equity securities have yet to be established and there can be no assurance that such equity 
securities will be issued. In the event, however, that the Company shall issue one or more types of equity securities (a “ Transaction ”) before the 
maturity of this Note, the Company shall in each event notify the Holder in writing within ten (10) days of such issuance of the terms of the 
Transaction and the Holder shall have the option until the later of (a) ten (10) days after such notice or (b) December 15, 2013 to elect in writing 
to convert all or a portion of the principal and accrued interest under this Note into the equity securities that were issued by the Company on the 
same terms that the Company issued said securities in such Transaction. The Company shall not issue fractional shares upon a conversion. If the 
application of the Conversion price shall contemplate issuance of less than a half share, such fractional share shall not be issued and no payment 
shall be made to the converting Holder and should such application result in the issuance of a half or greater fractional share, such fractional 
share shall be rounded up to the next full share.  

   
   
   
   
  
   
   
   
   
   
  
ARTICLE II.  

Section 2.01 No Prepayment . This Note may not be prepaid by the Company without the express written consent of the Holder.  

Section 2.02 Pari Passu With Other Notes . The payment of this Note and other similar notes issued for up to an aggregate principal 
sum of $3,000,000 shall be made in full by the Company and if the Company is unable to fully repay all such notes, then payment shall be on a 
pari passu basis.  

ARTICLE III.  

Section 3.01 Re-issuance of Note . Should the Holder elect to convert a part, but not all, of the unpaid principal amount then owing to 
the Holder under this Note, then the Company shall reissue a new Note in the same form as this Note to reflect the new principal amount and the 
accrued unpaid interest which was not converted.  

Section 3.02 Notices . Notices regarding this Note shall be sent to the parties at the following addresses, unless a party notifies the other 

parties, in writing, of a change of address:  

If to the Holder, to: 

If to the Company: 

Cryoport, Inc. 
20382 Barents Sea Circle 
Lake Forest, CA 92101 

Section 3.03 Governing Law . This Note shall be deemed to be made under and shall be construed in accordance with the laws of the 

state of Nevada without giving effect to the principals of conflict of laws thereof.  

Section 3.04 Severability . The invalidity of any of the provisions of this Note shall not invalidate or otherwise affect any of the other 

provisions of this Note, which shall remain in full force and effect.  

Section 3.05 Entire Agreement and Amendments . This Note represents the entire agreement between the parties hereto with respect 
to the subject matter hereof and there are no representations, warranties or commitments, except as set forth herein. This Note may be amended 
only by an instrument in writing executed by the parties hereto.  

Section 3.06. No Waiver, Cumulative Remedies . No failure to exercise and no delay in exercising, on the part any party, any right, 
remedy, power or privilege hereunder, shall operate as a waiver thereof, nor shall any single or partial exercise of any right, remedy, power or 
privilege  hereunder  preclude  any  other  or  further  exercise  thereof  or  the  exercise  of  any  other  right,  remedy,  power  or  privilege.  The  rights, 
remedies, powers and privileges herein provided are cumulative and not exhaustive of any rights, remedies, powers and privileges provided by 
law.  

Section 3.07 Waiver of Trial by Jury . To the extent permitted by applicable Law, each of the parties irrevocably waives all right of 

trial by jury in any action, proceeding or counterclaim arising out of or in connection with this Note or any matter arising hereunder.  

   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
Section .3.08 Legal Holidays . In any case where the date on which any payment is due to any Holder shall not be a business day, then 
any such payment need not be made on such date, but may be made on the next succeeding business day with the same force and effect as if 
made on the date on which nominally due, and no interest shall accrue for the period from and after any such nominal date.  

IN WITNESS WHEREOF, with the intent to be legally bound hereby, the Company as executed this Note as of the date first written 

above.  

CRYOPORT, INC. 

By: 

a duly authorized officer 

   
   
   
    
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
STOCK OPTION AGREEMENT  

Exhibit 10.28 

This  Stock  Option  Agreement  (“Agreement”)  is  between  CryoPort,  Inc.  (“Company”)  and  Jerrell  Shelton  (the  “Optionee”),  and  is 

effective as of the 5th day of November , 2012 (“Grant Date”).  

RECITALS  

A.         The Company is granting the option to purchase shares of the Company’s Common Stock contained in this Agreement pursuant 
to  the  terms  of  that  certain  Employment  Agreement  between  Optionee  and  the  Company  dated  November  5,  2012  (the  “Employment 
Agreement”).  

B.         The Employment Agreement and the grant of the option to purchase shares of the Company’s Common Stock contained in this 
Agreement has been approved by the Board of Directors of the Company (the “Board”) and by the Compensation Committee of the Board of 
Directors of the Company (the “Committee”) pursuant to the Unanimous Written Consent of the Board and Committee dated November 5, 2012. 

AGREEMENT  

In consideration of the mutual covenants and conditions hereinafter set forth and for other good and valuable consideration, the receipt 

and sufficiency of which are hereby acknowledged, the Company and the Optionee agree as follows:  

2.          Grant of Option . Subject to the terms of this Agreement, the Company grants to the Optionee the right and option to purchase 
from the Company all or any part of an aggregate of 1,000,000 shares of the Common Stock of the Company (“Option”). The Option granted 
under this Agreement is not intended to be an “incentive stock option” under Section 422 of the Internal Revenue Code of 1986, as amended 
(the “Code”).  

3.          Purchase Price . The purchase price under this Agreement is $0.20 per share of Common Stock of the Company (“Stock”), 

which is equal to the fair market value of a share of Stock on the Grant Date.  

4.          Vesting of Option . The Option shall vest and be exercisable according to the following schedule:  

1/6 of the option vests on the 5 th of each month for six months beginning on 12/5/2012 and ending on 5/5/2013;  

provided, that, pursuant to Section 12 below, such vesting will be accelerated in the event of a Change of Control (as defined in Section 12).  

5.          Exercise of Option . This Option may be exercised, to the extent vested (under Section 4 above), in whole or in part at any time 
before the Option expires by delivery of a written notice of exercise (under Section 7 below) and payment of the purchase price in cash or such 
other method permitted by the Committee under Section 6 and communicated to the Optionee before the date the Optionee exercises the Option.  

   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
6.          Payment . The Committee may determine methods other than cash by which the exercise price of the Option may be paid, the 
form of payment, including, without limitation, cash, promissory note, shares of Stock held for longer than six months (through actual tender or 
by  attestation),  any  net-issuance  arrangement  or  other  property  acceptable  to  the  Committee  (including  broker-assisted  “cashless  exercise”
arrangements), and the methods by which shares of Stock shall be delivered or deemed to be delivered to the Optionee.  

7.          Method of Exercising Option . Subject to the terms of this Agreement, the Option may be exercised by timely delivery to the 
Company of written notice, which notice shall be effective on the date received by the Company. The notice shall state the Optionee’s election to 
exercise the Option and the number of underlying shares in respect of which an election to exercise has been made. Such notice shall be signed 
by the Optionee, or if the Option is exercised by a person or persons other than the Optionee because of the Optionee’s death, such notice must 
be signed by such other person or persons and shall be accompanied by proof acceptable to the Company of the legal right of such person or 
persons to exercise the Option.  

8.          Term of Option . The Option granted under  this Agreement  expires at  the earlier of (a) ten (10) years from the Grant Date, 
through and including the normal close of business of the Company on the tenth (10 th ) anniversary of the Grant Date, and (b) five (5) years after 
the resignation and/or removal of the Optionee as Chief Executive Officer of the Company, through and including the normal close of business 
of the Company on the fifth (5 th ) anniversary of such anniversary or removal.  

8.           Tax Withholding . Unless otherwise provided by the Committee prior to the vesting of Option, the Optionee shall satisfy any 
federal, state, local or foreign employment or income taxes due upon the vesting of Option (or otherwise) by having the Company withhold from 
those  shares  of  Stock  that  the  Optionee  would  otherwise  be  entitled  to  receive,  a  number  of  shares  having  a  fair  market  value  equal  to  the 
minimum  statutory  amount  necessary  to  satisfy  the  Company’s  applicable  federal,  state,  local  and  foreign  income  and  employment  tax 
withholding obligations. Any such withholding shall be subject to the provisions of applicable law and to any conditions the Committee may 
determine  to  be  necessary  to  comply  with  Rule 16b-3  or  its  successors  under  the  Exchange  Act.  In  lieu  of,  and  subject  to,  the  above,  the 
Committee  may  also  permit the  Optionee  to satisfy  any  federal, state,  local,  or foreign  employment  or  income  taxes  due  upon  the  vesting  of 
Option (or otherwise) by (i) personal check or other cash equivalent acceptable to the Company, (ii) permitting the Optionee to execute a same 
day sale of Stock pursuant to procedures approved by the Company, or (iii) such other method as approved by the Committee, all in accordance 
with applicable Company policies and procedures and applicable law.  

9.           Nontransferability  .  The  Option  granted  by  this  Agreement  shall  not  be  transferable  by  the  Optionee  or  any  other  person 

claiming through the Optionee, either voluntarily or involuntarily, except by will or the laws of descent and distribution.  

10.          Nonstatutory  Stock  Option  .  The  Option  granted  hereunder  is  a  nonstatutory  (non-qualified)  stock  option,  and  is  not  an 

“incentive stock option” pursuant to the Code.  

11.         Stock Certificates . Notwithstanding anything herein to the contrary, the Company shall not be required to issue or deliver any 
certificates evidencing shares of Stock pursuant to the exercise of the Option, unless and until the Committee has determined, with advice of 
counsel, that the issuance and delivery of such certificates is in compliance with all applicable laws, regulations of governmental authorities and, 
if  applicable,  the  requirements  of  any  exchange  or  quotation  system  on  which  the  shares  of  Stock  are  listed,  quoted  or  traded.  All  Stock 
certificates delivered pursuant to this Agreement are subject to any stop-transfer orders and other restrictions as the Committee deems necessary 
or advisable to comply with Federal, state, or foreign jurisdiction, securities or other laws, rules and regulations and the rules of any national 
securities exchange or automated quotation system on which the Stock is listed, quoted, or traded. The Committee may place legends on any 
Stock certificate to reference restrictions applicable to the Stock. In addition to the terms and conditions provided herein, the Board may require 
that the Optionee make such reasonable covenants, agreements, and representations as the Board, in its discretion, deems advisable in order to 
comply with any such laws, regulations, or requirements.  

   
   
   
   
   
   
   
   
   
  
  
12.          Change in Control . Notwithstanding any other provision herein to the contrary, upon a Change in Control, the entire Option 

shall automatically become immediately vested and/or exercisable and that all restrictions relating to the Option shall lapse.  

a.            “Change in Control” means any one or more of the following events:  

(i)         The date that any one person, or more than one person acting as a group (as determined in accordance with 
Treasury  Regulation Section 1.409A-3(i)(5)),  acquires  ownership  of  stock  of  the  Company  that,  together  with  stock  held  by  such  person  or 
group, constitutes more than 50% of the total fair market value or total voting power of the stock of the Company. If any one person or more 
than one person acting as a group is considered to own more than 50% of the total fair market value or total voting power of the stock of the 
Company, the acquisition of additional stock by the same person or persons will not be considered to be a “Change of Control.” This paragraph 
(i) only  applies  when  there  is  a  transfer  of  stock  of  the  Company  (or  issuance  of  stock  of  the  Company)  and  stock  in  the  Company  remains 
outstanding after the transaction;  

(ii)         The date that any one person, or more than one person acting as a group (as determined in accordance with 
Treasury  Regulation Section 1.409A-3(i)(5)),  acquires  (or  has  acquired  during  the  12-month  period  ending  on  the  date  of  the  most  recent 
acquisition by such person or persons) assets from the Company that have a total gross fair market value equal to or more than 40% of the total 
gross fair market value of all of the assets of the Company immediately prior to such acquisition or acquisitions. For this purpose, “gross fair 
market  value”  means  the  value  of the  assets  of  the  Company,  or  the  value of the  assets  being disposed  of,  determined  without regard  to  any 
liabilities associated with such assets; or  

(iii)         The  date  that  any  person,  or  more  than  one  person  acting  as  a  group  (as  determined  in  accordance  with 
Treasury Regulation 1.409A-3(i)(5)), acquires (or has acquired during the 12-month period ending on the most recent acquisition by such person 
or persons) ownership of stock of Company possessing 30% or more of the total voting power of the stock of Company.  

The transfer of stock or assets of the Company in connection with a bankruptcy filing by or against the Company under Title 11 of the United 
States Code will not be considered to be a Change of Control for purposes of this Agreement. Additionally, a transaction shall not constitute a 
Change in Control if its sole purpose is to change the state of the Company’s incorporation or to create a holding company that will be owned in 
substantially the same proportions by the persons who held the Company’s securities immediately before such transaction.  

13.           Waiver  and  Modification  .  The  provisions  of  this  Agreement  may  not  be  waived  or  modified  unless  such  waiver  or 

modification is in writing and signed by a representative of the Committee.  

14.           Adjustments  .  In  the  event  of  any  change  in  the  outstanding  shares  of  Stock  by  reason  of  a  stock  dividend  or  split, 
recapitalization, merger, consolidation, combination, exchange of shares, or other similar corporate change, the aggregate number of shares of 
Stock  subject  to  the  Option  and  its  stated  exercise  price  shall  be  adjusted  appropriately  by  the  Committee,  whose  determination  shall  be 
conclusive; provided, however, that fractional shares shall be rounded to the nearest whole share. Moreover, in the event of such transaction or 
event, the Committee, in its discretion, may provide in substitution for the Option such alternative consideration (including cash) as it, in good 
faith, may determine to be equitable under the circumstances and may require in connection therewith the surrender of the Option so replaced. 
Further,  with  respect  to  any  Option  that  otherwise  satisfies  the  requirements  of  the  stock  rights  exception  to  Section 409A  of  the  Code,  any 
adjustment  pursuant  to  this  Section 14  shall  be  made  consistent  with  the  requirements  of  the  final  regulations  promulgated  pursuant  to 
Section 409A of the Code.  

   
   
   
   
   
   
   
   
   
  
  
15.          Requirements of Law  

a.          Securities Act . The Company shall not be required to deliver any shares of Stock pursuant to the vesting of the Option 
if, in the opinion of counsel for the Company, such issuance would violate the Securities Act of 1933 or any other applicable federal or state 
securities laws or regulations. The granting of the Option and the issuance of shares and/or cash under this Agreement shall be subject to all 
applicable laws, rules, and regulations, and to such approvals by any governmental agencies or national securities exchanges as may be required. 
The  Company  shall  be  under  no  obligation  to  register  pursuant  to  the  Securities  Act  of  1933,  as  amended,  any  of  the  shares  of  Stock  paid 
pursuant  to  the  Agreement.  If  the  shares  of  Stock  paid  pursuant  to  the  Agreement  may  in  certain  circumstances  be  exempt  from  registration 
pursuant to the Securities Act of 1933, as amended, the Company may restrict the transfer of such shares in such manner as it deems advisable to 
ensure the availability of any such exemption.  

b.           Securities  Law  Compliance  .  If  Optionee  is  obligated  to  file  reports  pursuant  to  Section 16  of  the  Exchange  Act, 
transactions pursuant  to this  Agreement are  intended to comply  with all  applicable  conditions of Rule 16b-3 or  its successors pursuant to  the 
Securities Exchange Act of 1934. Notwithstanding any other provision herein, the Committee may impose such conditions on the exercise of the 
Option as may be required to satisfy the requirements of Rule 16b-3 or its successors pursuant to the Securities Exchange Act of 1934. To the 
extent any provision herein or action by the Committee fails to so comply, it shall be void to the extent permitted by law and voidable as deemed 
advisable by the Committee.  

c.          Restrictions . The Committee shall impose such restrictions on the Option as it may deem advisable, including without 
limitation, restrictions under applicable federal securities law, under the requirements of any Stock exchange upon which the Stock is then listed 
and under any blue sky or state securities laws applicable to such Option.  

16.          Section 409A of the Code .  

a.          General Compliance . If this Agreement is subject to Section 409A of the Code, the Company intends (but cannot and 
does  not  guarantee)  that  this  Agreement  complies  fully  with  and  meets  all  of  the  requirements  of  Section 409A  of  the  Code  or  an  exception 
thereto.  To  the  extent  necessary  to  comply  with  Section 409A  of  the  Code,  this  Agreement  may  be  modified,  replaced  or  terminated  in  the 
discretion of the Committee. Notwithstanding any provision of this Agreement to the contrary, in the event that the Committee determines that 
this Agreement is or may become subject to Section 409A of the Code, the Company may adopt such amendments to this Agreement, without 
the consent of Optionee, or adopt other policies and procedures (including amendments, policies and procedures with retroactive effective dates), 
or take any other action that the Committee determines to be necessary or appropriate to either comply with Section 409A of the Code or to 
exclude or exempt this Agreement from the requirements of Section 409A of the Code.  

b.           Delay  for  Specified  Employees  .  If,  at  the  time  of  Optionee’s  “separation  of  service”  the  Company  has  any  Stock 
which is publicly traded on an established securities market or otherwise, and if the Optionee is considered to be a “specified employee” to the 
extent any payment or consideration under this Agreement is subject to the requirements of Section 409A of the Code and is payable upon the 
Optionee’s  “separation  from  service,”  such  payment  shall  not  commence  prior  to  the  first  business  day  following  the  date  which  is  six 
(6) months after the Optionee’s “separation from service” (or if earlier than the end of the six (6) month period, the date of the Optionee’s death). 
Any amounts that would have been distributed during such six (6) month period will be distributed on the day following the expiration of the six 
(6) month period.  

   
   
   
   
   
   
   
   
  
  
c.          Prohibition on Acceleration or Deferral . Under no circumstances may the time or schedule of any payment for any 
amount under this Agreement that is subject to the requirements of Section 409A of the Code be accelerated or subject to further deferral except 
as otherwise permitted or required pursuant to regulations and other guidance issued pursuant to Section 409A of the Code. If the Company fails 
to  make  any  payment  pursuant  to  the  payment  provisions  applicable  to  this  Agreement  that  is  subject  to  Section 409A  of  the  Code,  either 
intentionally or unintentionally, within the time period specified in such provisions, but the payment is made within the same calendar year, such 
payment  will  be  treated as made within  the  time  period specified in  the provisions.  In  addition, in  the  event  of  a dispute  with respect  to  any 
payment, such payment may be delayed in accordance with the regulations and other guidance issued pursuant to Section 409A of the Code.  

17.          Voting and Other Shareholder Related Rights . The Optionee will have no voting rights or any other rights as a shareholder 

of the Company with respect to any Option until exercised by the Optionee.  

18.          Governing Law . This Agreement shall be interpreted and administered under the laws of the State of Nevada.  

19.          Amendments . This Agreement may be amended only by a written agreement executed by the Company and the Optionee.  

IN WITNESS WHEREOF, the Company has caused this Agreement to be executed by its duly authorized representative and Optionee 

has signed this Agreement, and this Agreement shall be effective as of the day and year first written above.  

November 5, 2012 
Date 

CryoPort, Inc. 

By: 
Name: 
Title: 

/s/ Robert Stefanovich 
Robert Stefanovich 
Chief Financial Officer 

/s/ Jerrell W. Shelton 
Optionee 

   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
Cryoport Systems, Inc.  

CRYOPORT, INC.  
Subsidiaries of Registrant  

EXHIBIT 21 

   
  
   
   
  
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

We consent to the incorporation by reference in the Registration Statement No. 333-166327 on Form S-8 of our report dated June 25, 2013 
(which includes an explanatory paragraph regarding Cryoport, Inc.’s ability to continue as a going concern), with respect to the consolidated 
financial statements of Cryoport, Inc. included in this Annual Report on Form 10-K of Cryoport, Inc. for the years ended March 31, 2013 and 
2012.  

Exhibit 23.1 

/s/ KMJ Corbin & Company LLP 

Costa Mesa, California 
June 25, 2013 

   
  
   
   
   
   
  
  
  
  
  
  
EXHIBIT 31.1 

I, Jerrell Shelton, certify that:  

1. I have reviewed this annual report on Form 10-K of Cryoport, Inc.;  

Certification of Chief Executive Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make 
the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by 
this report;  

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects 
the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;  

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in 
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 
15d-15(f)) for the registrant and have:  

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our 
supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others 
within those entities, particularly during the period in which this report is being prepared;  

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our 

supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for 
external purposes in accordance with generally accepted accounting principles;  

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the 

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and  

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most 

recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to 
materially affect, the registrant’s internal control over financial reporting; and  

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, 
to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):  

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are 

reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and  

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal 

control over financial reporting.  

Dated: June 25, 2013 

Signed:     /s/ JERRELL SHELTON 
   Jerrell Shelton 
   Chief Executive Officer and Director 

   
  
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
Certification of Chief Financial Officer  
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002  

EXHIBIT 31.2 

I, Robert Stefanovich, certify that:  

1. I have reviewed this annual report on Form 10-K of Cryoport, Inc.;  

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make 
the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by 
this report;  

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects 
the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;  

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in 
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 
15d-15(f)) for the registrant and have:  

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our 
supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others 
within those entities, particularly during the period in which this report is being prepared;  

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our 

supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for 
external purposes in accordance with generally accepted accounting principles;  

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the 

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and  

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most 

recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to 
materially affect, the registrant’s internal control over financial reporting; and  

5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to 
the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):  

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are 

reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and  

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal 

control over financial reporting.  

Dated: June 25, 2013 

Signed:     /s/ ROBERT STEFANOVICH 

   Robert Stefanovich 
   Chief Financial Officer 

   
  
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
  
  
  
  
  
  
  
  
Certification Pursuant to U.S.C. §1350 Chief Executive Officer  

I, Jerrell Shelton, Chief Executive Officer of Cryoport, Inc. (the “Company”), certify, pursuant to Rule 13(a)-14(b) or Rule 15(d)-14(b) of 

the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2013 (the “Report”) fully complies with the 
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the 
Company.  

EXHIBIT 32.1 

Dated: June 25, 2013  

/s/ Jerrell Shelton 
Jerrell Shelton, Chief Executive Officer and Director 

A signed original of this written statement required by Section 906 has been provided to Cryoport, Inc. and will be retained by Cryoport, 

Inc. and furnished to the Securities and Exchange Commission or its staff upon request.  

This Certification is being furnished pursuant to Rule 15(d) and shall not be deemed “filed” for purposes of Section 18 of the Exchange 

Act (15 U.S.C. 78r), or otherwise subject to the liability of that section. This Certification shall not be deemed incorporated by reference into any 
filing under the Securities Act or the Exchange Act, except to the extent that the Company specifically incorporates it by reference.  

   
  
   
   
   
   
   
   
   
   
   
  
  
  
Certification Pursuant to U.S.C. §1350 of Chief Financial Officer  

I, Robert Stefanovich, Chief Financial Officer of Cryoport, Inc. (the “Company”), certify, pursuant to Rule 13(a)-14(b) or Rule 15(d)-14

(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:  

(1) the Annual Report on Form 10-K of the Company for the fiscal year ended March 31, 2013 (the “Report”) fully complies with the 
requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 780(d)); and  

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the 
Company.  

EXHIBIT 32.2 

Dated: June 25, 2013  

/s/ Robert Stefanovich 
Robert Stefanovich, Chief Financial Officer 

A signed original of this written statement required by Section 906 has been provided to Cryoport, Inc. and will be retained by Cryoport, 

Inc. and furnished to the Securities and Exchange Commission or its staff upon request.  

This Certification is being furnished pursuant to Rule 15(d) and shall not be deemed “filed” for purposes of Section 18 of the Exchange 

Act (15 U.S.C. 78r), or otherwise subject to the liability of that section. This Certification shall not be deemed incorporated by reference into any 
filing under the Securities Act or the Exchange Act, except to the extent that the Company specifically incorporates it by reference.