Cytokinetics Annual Report 2016

Plain-text annual report

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549 Form 10-K (Mark One) ☑ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2016or ☐TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934From the transition period from to Commission file number: 000-50633CYTOKINETICS, INCORPORATED(Exact name of registrant as specified in its charter) Delaware 94-3291317(State or other jurisdiction ofincorporation or organization) (I.R.S. EmployerIdentification No.) 280 East Grand AvenueSouth San Francisco, CA 94080(Address of principal executive offices) (Zip Code)(650) 624-3000(Registrant’s telephone number, including area code)Securities registered pursuant to Section 12(b) of the Act: Title of each class Name of each exchange on which registeredCommon Stock, $0.001 par value The NASDAQ Capital MarketSecurities registered pursuant to Section 12(g) of the Act:NoneIndicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☑Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ☐ No ☑Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filingrequirements for the past 90 days. Yes ☑ No ☐Indicate by check mark whether the Registrant has submitted electronically and posted on its corporate Website, if any, every Interactive Data Filerequired to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorterperiod that the registrant was required to submit and post such files). Yes ☑ No ☐Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405 of this chapter) is not contained herein, andwill not be contained, to the best of the Registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of thisForm 10-K or any amendment to this Form 10-K. ☑Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. Seethe definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. Large accelerated filer ☐ Accelerated filer ☑ Non-accelerated filer ☐ Smaller reporting company ☐(Do not check if a smaller reporting company)Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☑The aggregate market value of the voting and non-voting common equity held by non-affiliates was $375.5 million, computed by reference to the lastsales price of $9.49 as reported by the NASDAQ Market as of June 30, 2016. This calculation does not reflect a determination that certain persons areaffiliates of the Registrant for any other purpose. The number of shares of common stock held by non-affiliates excluded 130,998 shares of common stockheld by directors, officers and affiliates of directors. The number of shares owned by affiliates of directors was determined based upon information suppliedby such persons and upon Schedules 13D and 13G, if any, filed with the SEC. Exclusion of shares held by any person should not be construed to indicate thatsuch person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, that such person iscontrolled by or under common control with the Registrant, or that such persons are affiliates for any other purpose.The number of shares outstanding of the Registrant’s common stock on February 23, 2017 was 41,729,549 shares.DOCUMENTS INCORPORATED BY REFERENCEPortions of the Registrant’s Proxy Statement for its 2017 Annual Meeting of Stockholders to be filed with the Securities and Exchange Commission, nolater than 120 days after the end of the fiscal year, are incorporated by reference into Part III of this Annual Report on Form 10-K. Table of ContentsCYTOKINETICS, INCORPORATEDFORM 10-KYear Ended December 31, 2016INDEX Page PART I Item 1. Business 3 Item 1A. Risk Factors 27 Item 1B. Unresolved Staff Comments 56 Item 2. Properties 56 Item 3. Legal Proceedings 56 Item 4. Mine Safety Disclosures 57 PART II Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities 58 Item 6. Selected Financial Data 60 Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations 61 Item 7A. Quantitative and Qualitative Disclosures About Market Risk 85 Item 8. Financial Statements and Supplementary Data 87 Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure 130 Item 9A. Controls and Procedures 130 Item 9B. Other Information 131 PART III Item 10. Directors, Executive Officers and Corporate Governance 132 Item 11. Executive Compensation 132 Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters 132 Item 13. Certain Relationships and Related Transactions, and Director Independence 132 Item 14. Principal Accounting Fees and Services 133 PART IV Item 15. Exhibits and Financial Statement Schedules 134 Item 16. Form 10-K Summary 140 Signatures 141 Table of ContentsPART IThis report contains forward-looking statements indicating expectations about future performance and other forward-looking statements within themeaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), Section 21E of the Securities Exchange Act of 1934, as amended(the “Exchange Act”), and the Private Securities Litigation Reform Act of 1995, that involve risks and uncertainties. We intend that such statements beprotected by the safe harbor created thereby. Forward-looking statements involve risks and uncertainties and our actual results and the timing of events maydiffer significantly from the results discussed in the forward-looking statements. Examples of such forward-looking statements include, but are not limited to,statements about or relating to: • guidance concerning revenues, research and development expenses and general and administrative expenses for 2017; • the sufficiency of existing resources to fund our operations for at least the next 12 months; • our capital requirements and needs for additional financing; • the initiation, design, conduct, enrollment, progress, timing and scope of clinical trials and development activities for our drug candidatesconducted by ourselves or our partners, Amgen Inc. (“Amgen”) and Astellas Pharma Inc. (“Astellas”), including the anticipated timing for initiationof clinical trials, anticipated rates of enrollment for clinical trials and anticipated timing of results becoming available or being announced fromclinical trials; • the results from the clinical trials, the non-clinical studies and chemistry, manufacturing, and controls (“CMC”) activities of our drug candidates andother compounds, and the significance and utility of such results; • anticipated interactions with regulatory authorities; • the further development of tirasemtiv for the potential treatment of amyotrophic lateral sclerosis (“ALS”); • the expected acceptability by regulatory authorities of the effects of tirasemtiv on slow vital capacity or other measures of clinical benefit related torespiratory function in patients with ALS as Phase 3 clinical trial endpoints to support the registration of tirasemtiv as a treatment for ALS; • our and our partners’ plans or ability to conduct the continued research and development of our drug candidates and other compounds; • the advancement of omecamtiv mecarbil in Phase 3 clinical development; • our expected roles in research, development or commercialization under our strategic alliances with Amgen and Astellas; • the properties and potential benefits of, and the potential market opportunities for, our drug candidates and other compounds, including thepotential indications for which they may be developed; • the sufficiency of the clinical trials conducted with our drug candidates to demonstrate that they are safe and efficacious; • our receipt of milestone payments, royalties, reimbursements and other funds from current or future partners under strategic alliances, such as withAmgen or Astellas; • our ability to continue to identify additional potential drug candidates that may be suitable for clinical development; • our plans or ability to commercialize drugs with or without a partner, including our intention to develop sales and marketing capabilities; • the focus, scope and size of our research and development activities and programs; 1Table of Contents • the utility of our focus on the biology of muscle function, and our ability to leverage our experience in muscle contractility to other musclefunctions; • our ability to protect our intellectual property and to avoid infringing the intellectual property rights of others; • future payments and other obligations under loan and lease agreements; • potential competitors and competitive products; • retaining key personnel and recruiting additional key personnel; and • the potential impact of recent accounting pronouncements on our financial position or results of operations.Such forward-looking statements involve risks and uncertainties, including, but not limited to: • further clinical development of tirasemtiv for the potential treatment of ALS will require significant additional funding and we may be unable toobtain such additional funding on acceptable terms, if at all; • the U.S. Food and Drug Administration (“FDA”) and/or other regulatory authorities may not accept effects on respiratory function, including slowvital capacity, as appropriate clinical trial endpoints to support the registration of tirasemtiv for the treatment of ALS; • Amgen’s decisions with respect to the timing, design and conduct of research and development activities for omecamtiv mecarbil and relatedcompounds, including decisions to postpone or discontinue research or development activities relating to omecamtiv mecarbil and relatedcompounds; • Astellas’ decisions with respect to the timing, design and conduct of research and development activities for CK-2127107 and other skeletal muscleactivators, including decisions to postpone or discontinue research or development activities relating to CK-2127107 and other skeletal muscleactivators, as well as Astellas’ decisions with respect to its option to enter into a global collaboration for the development and commercialization oftirasemtiv; • our ability to enter into strategic partnership agreements for any of our programs on acceptable terms and conditions or in accordance with ourplanned timelines; • our ability to obtain additional financing on acceptable terms, if at all; • our receipt of funds and access to other resources under our current or future strategic alliances; • difficulties or delays in the development, testing, manufacturing or commercialization of our drug candidates; • difficulties or delays, or slower than anticipated patient enrollment, in our or partners’ clinical trials; • difficulties or delays in the manufacture and supply of clinical trial materials; • failure by our contract research organizations, contract manufacturing organizations and other vendors to properly fulfill their obligations orotherwise perform as expected; • results from non-clinical studies that may adversely impact the timing or the further development of our drug candidates and other compounds; • the possibility that the FDA or foreign regulatory agencies may delay or limit our or our partners’ ability to conduct clinical trials or may delay orwithhold approvals for the manufacture and sale of our products; • changing standards of care and the introduction of products by competitors or alternative therapies for the treatment of indications we target thatmay limit the commercial potential of our drug candidates; • difficulties or delays in achieving market access and reimbursement for our drug candidates and the potential impacts of health care reform; 2Table of Contents • changes in laws and regulations applicable to drug development, commercialization or reimbursement; • the uncertainty of protection for our intellectual property, whether in the form of patents, trade secrets or otherwise; • potential infringement or misuse by us of the intellectual property rights of third parties; • activities and decisions of, and market conditions affecting, current and future strategic partners; • accrual information provided by our contract research organizations (“CROs”), contract manufacturing organizations (“CMOs”), and other vendors; • potential ownership changes under Internal Revenue Code Section 382; and • the timeliness and accuracy of information filed with the U.S. Securities and Exchange Commission (the “SEC”) by third parties.In addition, such statements are subject to the risks and uncertainties discussed in the “Risk Factors” section and elsewhere in this document. Suchstatements speak only as of the date on which they are made, and, except as required by law, we undertake no obligation to update any forward-lookingstatement to reflect events or circumstances after the date on which the statement is made or to reflect the occurrence of unanticipated events. New factorsemerge from time to time, and it is not possible for us to predict which factors will arise. In addition, we cannot assess the impact of each factor on ourbusiness or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements.Item 1. BusinessWhen used in this report, unless otherwise indicated, “Cytokinetics,” “the Company,” “we,” “our” and “us” refers to Cytokinetics, Incorporated.CYTOKINETICS, and our logo used alone and with the mark CYTOKINETICS, are registered service marks and trademarks of Cytokinetics. Other servicemarks, trademarks and trade names referred to in this report are the property of their respective owners.OverviewWe were incorporated in Delaware in August 1997 as Cytokinetics, Incorporated. We are a late-stage biopharmaceutical company focused on thediscovery and developments of first-in-class muscle activators as potential treatment for debilitating diseases in which muscle performance is compromisedand/or declining. Our research and development activities relating to the biology of muscle function have evolved from our knowledge and expertiseregarding the cytoskeleton, a complex biological infrastructure that plays a fundamental role within every human cell. Our most advanced research anddevelopment programs relate to the biology of muscle function and are directed to small molecule modulators of the contractility of skeletal or cardiacmuscle. We are also conducting earlier-stage research directed to other compounds with the potential to modulate muscle contractility and other musclefunctions.Our lead drug candidate from our skeletal muscle contractility program, tirasemtiv (formerly known as CK-2017357), is a fast skeletal troponinactivator. We retain exclusive rights to tirasemtiv, subject to Astellas’ exercise of its option for a license to tirasemtiv (“Option on Tirasemtiv” see “Astellas’Option on Tirasemtiv” below). We conducted a Phase 2 clinical development program for tirasemtiv, including a Phase 2b clinical trial in patients with ALS,known as BENEFIT-ALS (Blinded Evaluation of Neuromuscular Effects and Functional Improvement with Tirasemtiv in ALS). Based on the results ofBENEFIT-ALS, we started a Phase 3 clinical development program for tirasemtiv in patients with ALS in July 2015 known as VITALITY-ALS (VentilatoryInvestigation of Tirasemtiv and Assessment of Longitudinal Indices after Treatment for a Year in ALS). Tirasemtiv has been granted orphan drug designationand fast track status by the FDA and orphan medicinal product designation by the European Medicines Agency, in each case for the potential treatment ofALS. 3Table of ContentsWe are also developing CK-2127107, a structurally distinct fast skeletal troponin activator, under a strategic alliance with Astellas. In June 2013, weexecuted a license and collaboration agreement with Astellas (the “Original Astellas Agreement”), that was amended and restated in December 2014 (the“2014 Astellas Agreement”) and further amended in 2016 (the “2016 Astellas Amendment”) collectively with the 2014 Astellas Agreement, the “CurrentAstellas Agreement.” The 2016 Astellas Amendment, which became effective in September 2016, expanded our collaboration to include the development ofCK-2127107 for the potential treatment of ALS, as well as the possible development in ALS of other fast skeletal regulatory activators licensed to Astellasunder the 2014 Astellas Agreement. The 2016 Astellas Amendment also extended the existing joint research program focused on the discovery of additionalnext-generation skeletal muscle activators through 2017, including sponsored research at Cytokinetics. Finally, under the 2016 Astellas Amendment, theCompany granted Astellas the Option on Tirasemtiv, an option to enter into a pre-negotiated agreement for a global collaboration for the development andcommercialization of tirasemtiv.Astellas holds an exclusive license to develop and commercialize CK-2127107 worldwide, subject to our development and commercializationparticipation rights. Under this strategic alliance, Cytokinetics conducted five Phase 1 clinical trials of CK-2127107 and started a Phase 2 clinical trial ofCK-2127107 in patients with spinal muscular atrophy (SMA) in December 2015. CK-2127107 is also being evaluated for the potential use in otherindications associated with muscle weakness. Astellas, in collaboration with Cytokinetics, started a Phase 2 clinical trial of CK-2127107 in patients withchronic obstructive pulmonary disease (“COPD”) in June 2016. We are also conducting joint research with Astellas directed to next-generation skeletalmuscle activators. Further details regarding our strategic alliance with Astellas can be found below in Item 1 of this report under “Research and DevelopmentPrograms — Skeletal Muscle Contractility Program — CK-2127107 and Other Skeletal Muscle Activators — Astellas Strategic Alliance.”Our lead drug candidate from our cardiac muscle contractility program, omecamtiv mecarbil (formerly known as CK-1827452), is a novel cardiacmuscle myosin activator that is being developed under a strategic alliance with Amgen. Amgen holds an exclusive, worldwide license to omecamtiv mecarbiland related compounds, subject to Cytokinetics’ specified development and commercialization rights. Amgen has also entered an alliance with Servier forexclusive commercialization rights in Europe as well as the Commonwealth of Independent States (“CIS”), including Russia. Servier contributes funding fordevelopment and provides strategic support to the program.Omecamtiv mecarbil has been the subject of an extensive Phase 1 and Phase 2 clinical trials program. An intravenous formulation of omecamtivmecarbil was studied in a Phase 2b clinical trial known as ATOMIC-AHF (Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute HeartFailure), which was designed to evaluate the safety and efficacy of omecamtiv mecarbil in patients with left ventricular systolic dysfunction who arehospitalized with acute heart failure. In October 2015, we announced the results of COSMIC-HF (Chronic Oral Study of Myosin Activation to IncreaseContractility in Heart Failure), the last planned Phase 2 trial of omecamtiv mecarbil to be completed prior to the decision regarding the advancement of thisdrug candidate to Phase 3. COSMIC-HF was designed to assess the pharmacokinetics and tolerability of omecamtiv mecarbil dosed orally in patients withheart failure and left ventricular systolic dysfunction and its effects on echocardiographic measures of cardiac function. In December 2016, we announced theactivation of the first trial site for a Phase 3 cardiovascular outcomes clinical trial of omecamtiv mecarbil conducted by Amgen, GALACTIC-HF (GlobalApproach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure). Cytokinetics and Amgen are also planning a potentialexercise performance/cardiac function clinical trial to be conducted by Cytokinetics; Amgen will be responsible for reimbursing us for the out-of-pocketdevelopment costs associated with this clinical trial. Further details regarding our strategic alliance with Amgen can be found below in Item 1 of this reportunder “Research and Development Programs — Cardiac Muscle Contractility Program — Amgen Strategic Alliance.”All of our drug candidates have demonstrated evidence of potentially clinically relevant pharmacodynamic activity in humans. In 2017, we expect tocontinue to focus on translating the observed pharmacodynamic activity of these compounds into potentially meaningful clinical benefits for patients. 4Table of ContentsFollowing is a summary of the planned clinical development activities for our drug candidates: DrugCandidate(Mechanism of Action) Partnership Status PotentialIndication(s) Current Stage of Development Development Status andPlanned Development ActivitiesSkeletal Muscle Contractility ProgramTirasemtiv(fast skeletaltroponin activator) Cytokinetics (1) ALS Phase 3 • We completed enrollment in a Phase 3 clinical trial oftirasemtiv in patients with ALS in the third quarter of2016 and began an open-label extension trial in thefourth quarter of 2016 for patients who have completedthe Phase 3 trial.CK-2127107(fast skeletaltroponin activator) Partneredwith Astellas SMA Phase 2/Phase 1b • We continued enrollment of Cohort 1 of a Phase 2clinical trial in patients with SMA. We anticipate that thetrial will complete enrollment and report data in thesecond half of 2017. COPD • Astellas initiated a Phase 2 clinical trial in patients withCOPD in the second quarter of 2016. ALS • We anticipate that we will begin a Phase 2 clinical trial inpatients with ALS mid-2017. Frailty • We anticipate that Astellas will begin a Phase 1b clinicaltrial in elderly patients with limited mobility in the firsthalf of 2017.Cardiac Muscle Contractility ProgramOmecamtiv mecarbil(cardiac muscle myosinactivator) Partneredwith Amgen heart failure(oral administration) Phase 3 • Amgen started GALACTIC-HF, a Phase 3 cardiovascularoutcomes clinical trial in patients with heart failure withreduced ejection fraction in December 2016. (1)Cytokinetics developing independently, subject to Astellas’ option on tirasemtivAll of our drug candidates have arisen from our cytoskeletal research activities. Our focus on the biology of the cytoskeleton distinguishes us fromother biopharmaceutical companies, and potentially positions us to discover and develop novel therapeutics that may be useful for the treatment of severediseases and medical conditions. Each of our drug candidates has a novel mechanism of action compared to currently marketed drugs, which we believevalidates our focus on the cytoskeleton as a productive area for drug discovery. We intend to leverage our experience in muscle contractility in order toexpand our current pipeline, and expect to identify additional potential drug candidates that may be suitable for clinical development.Corporate StrategyWe are a late-stage biopharmaceutical company focused on the discovery and development and commercialization of first-in-class muscle activators aspotential treatment for debilitating diseases in which 5Table of Contentsmuscle performance is compromised and/or declining. As a leader in muscle biology and the mechanics of muscle performance, the company is developingsmall molecule drug candidates specifically engineered to increase muscle function and contractility. Over the next 5 years, our goal is to discover, developand commercialize novel drug products that modulate muscle function in ways that may benefit people living with serious diseases or medical conditions,with the intent of establishing a fully integrated biopharmaceutical company.The five key components of our Corporate Strategy, “Vision 2020: Empowering Our Future,” are: • Conduct late-stage clinical development of novel, first-in-class muscle activators for the potential treatment of ALS, SMA, heart failure and otherdiseases impacting muscle function. As we enter 2017, our portfolio consists of three products that are in mid-late stage clinical development inthree therapeutic areas, namely ALS, SMA and heart failure. We believe that by focusing on these disease areas characterized by well-organizedphysician-investigator groups, significant unmet clinical needs, and strong patient and disease advocacy, we may enhance our effectiveness inenrolling and conducting clinical trials that may answer important questions about the dosing, tolerability, pharmacokinetics andpharmacodynamics as well as the potential safety and efficacy of our drug candidates. We believe that our considered clinical trial designs and well-executed development programs can improve our ability to realize value from our and our partners’ clinical development activities. As we advanceour drug candidates into later-stage clinical development, we extensively evaluate previous clinical trial designs and results to assess key learningsthat may be applied to our late-stage clinical development activities. We believe this may result in more successful later-stage clinical developmentactivities that may increase the likelihood of achieving our objectives to develop effective therapies that may address the needs of people livingwith these devastating diseases. • Collaborate with patient communities to support the urgent development of new medicines for diseases of impaired muscle function with pressingunmet medical needs. Central to our corporate strategy are the people living with a disease or medical condition characterized by impaired musclefunction. We focused our development and commercialization activities on diseases that lack effective therapies and, in some cases, those with noapproved medicines. We recognize that by applying our extensive knowledge of muscle biology towards the development of novel therapies for thepeople living with these diseases, not only patients but their caregivers and families, we aim to improve their lives. As such, we need to collaboratewith these individuals and their communities to ensure our therapeutics are addressing their urgent needs and that we understand and appreciate theissues associated with these diseases and conditions. We work collaboratively with entities, such as patient advocacy groups, that are focused onpolicies, guidelines and practices to accelerate development and commercialization of novel therapies, where possible and appropriate, and onensuring that the voice of their constituency is heard. • Mature our company’s operations to enable development, registration and commercialization of muscle biology drug candidates across NorthAmerica and Europe. With a focus on disease areas for which there are serious unmet medical needs, we direct our activities to potentialcommercial opportunities in concentrated and tractable customer segments, such as hospital specialists and disease-specific centers of excellence,which may be addressed by a smaller, targeted sales force. In preparing for the potential commercialization of our drug candidates directed to thesemarkets, we are focusing our activities on a broad range of issues facing patients and payors, including the principal drivers of clinical andeconomic burdens associated with these diseases. We also seek to focus on opportunities that the multiple constituencies and stakeholders for thesemarkets may recognize as creating value. Accordingly, targeting unmet medical needs in these areas may provide us competitive opportunities andsupport development of a franchise in diseases involving muscle weakness, wasting and fatigue. In these markets, we believe that a company withlimited resources may be able to compete effectively against larger, more established companies with greater financial and commercial resources.For these opportunities, we intend to develop clinical development and sales and marketing capabilities in North America and Europe with the goalof becoming a fully integrated biopharmaceutical company. 6Table of Contents • Advance next-generation skeletal and cardiac muscle activator compounds into clinical development by leveraging existing researchcollaborations. We take a purpose-driven approach by leveraging our extensive muscle biology expertise to engineer compounds with specificcharacteristics aimed at treating diseases that impact muscle function. By increasing muscle strength and performance, the potential treatments weare developing may preserve and extend independence and self-reliance in people suffering from debilitating diseases. We have established selectstrategic alliances to support our drug development programs while preserving significant development and commercialization rights. We believethat such alliances may allow us to obtain financial support and to capitalize on the therapeutic area expertise and resources of our partners that canpotentially accelerate the development and commercialization of our drug candidates. Where we deem appropriate, we plan to retain certain rightsto participate in the development of drug candidates and commercialization of potential drugs arising from our programs and alliances, so that wecan expand and capitalize on our own internal development capabilities and build our commercialization capabilities. • Progress proprietary research programs focused on muscle into development under new collaborations. We believe that our extensiveunderstanding of muscle biology and our proprietary research technologies should enable us to discover and potentially to develop drug candidateswith novel mechanisms of action that may offer potential benefits not provided by existing drugs and which may have application across a broadarray of diseases and medical conditions. We expect that we may be able to leverage our expertise in muscle contractility to expand programsrelated to other areas of muscle function and which may extend to the potential treatment of other serious medical diseases and conditions.Progressing related programs in parallel may afford us an opportunity to build a broader business that could benefit from multiple products thatserve related clinical and commercial needs associated with impaired muscle function, muscle weakness and fatigue. In addition, this strategy mayenable us to diversify certain technical, financial and operating risks by advancing several drug candidates in parallel.Research and Development ProgramsOur long-standing interest in the cytoskeleton has led us to focus our research and development activities on the biology of muscle function and, inparticular, small molecule modulation of muscle contractility. We believe that our expertise in the modulation of muscle contractility is an importantdifferentiator for us. Our preclinical and clinical experience in muscle contractility may position us to discover and develop additional novel therapies thathave the potential to improve the health of patients with severe and debilitating diseases or medical conditions.Small molecules that affect muscle contractility may have several applications for a variety of serious diseases and medical conditions. For example,certain diseases and medical conditions associated with muscle weakness may be amenable to treatment by enhancing the contractility of skeletal muscle.Similarly, heart failure is a disease often characterized by impaired cardiac muscle contractility which may be treated by modulating the contractility ofcardiac muscle. Because the modulation of the contractility of different types of muscle, such as cardiac and skeletal muscle, may be relevant to multiplediseases or medical conditions, we believe we can leverage our expertise in these areas to more efficiently discover and develop potential drug candidatesthat modulate the applicable muscle type for multiple indications.We are currently developing a number of small molecule compounds arising from our muscle contractility programs.Tirasemtiv is our lead drug candidate from our skeletal muscle contractility program. Potential indications for which this drug candidate may be usefulinclude skeletal muscle weakness associated with neuromuscular diseases, such as ALS. We have conducted a Phase 2 clinical trials program for tirasemtiv,and completed enrollment in a Phase 3 clinical development program of this drug candidate in patients with ALS in August 7Table of Contents2016. We retain exclusive rights to tirasemtiv, subject to Astellas’ exercise of its option on tirasemtiv (see “Astellas’ Option on Tirasemtiv” below).CK-2127107, another drug candidate from this program, is partnered with Astellas world-wide for the potential treatment of SMA and potentially otherneuromuscular and non-neuromuscular indications associated with muscle weakness. We conducted a Phase 1 clinical trials program for CK-2127107 underthis collaboration. We started a Phase 2 clinical trial of CK-2127107 in patients with SMA in December 2015. Astellas, in collaboration with Cytokinetics,started a Phase 2 clinical trial of CK-2127107 in patients with COPD in June 2016 and the Company anticipates they will initiate a Phase 1b clinical trial ofCK-2127107 in elderly patients with limited mobility in the first half of 2017. We anticipate that we will initiate a Phase 2 clinical trial in patients with ALSmid-2017. Cytokinetics and Astellas continue to evaluate other indications which may be suitable for CK-2127107 or other skeletal sarcomere activatorsunder the collaboration.Omecamtiv mecarbil, our novel cardiac muscle myosin activator, is partnered with Amgen world-wide. Phase 2 clinical trials were conducted with bothintravenous and oral formulations of omecamtiv mecarbil. An intravenous formulation of omecamtiv mecarbil was studied in ATOMIC-AHF, a Phase 2bclinical trial in patients with acute heart failure, and an oral formulation of omecamtiv mecarbil was studied in COSMIC-HF, a Phase 2 clinical trial inpatients with heart failure. In December 2016, we announced the start of GALACTIC-HF, a Phase 3 clinical trial which is being conducted by Amgen incollaboration with Cytokinetics. Amgen holds an exclusive, worldwide license to omecamtiv mecarbil and related compounds, subject to Cytokinetics’specified development and commercialization rights. Amgen has also entered into an alliance with Servier for exclusive commercialization rights in Europeas well as the CIS, including Russia.We are continuing to conduct discovery, characterization and lead optimization activities for other compounds with the potential to modulate musclecontractility and other muscle functions.Research and Development Expense. Our research and development expenses were $59.9 million, $46.4 million and $44.4 million for 2016, 2015and 2014, respectively.Skeletal Muscle Contractility ProgramOverviewOur skeletal muscle contractility program is focused on the activation of the skeletal sarcomere, the basic unit of skeletal muscle contraction. Theskeletal sarcomere is a highly ordered cytoskeletal structure composed of skeletal muscle myosin, actin, and a set of regulatory proteins, which include thetroponins and tropomyosin. This program leverages our expertise developed in our ongoing discovery and development of cardiac sarcomere activators,including the cardiac muscle myosin activator omecamtiv mecarbil.We believe that our skeletal sarcomere activators may lead to new therapeutic options for diseases and medical conditions associated with aging,muscle weakness and wasting and neuromuscular dysfunction. The clinical effects of muscle weakness and wasting, fatigue and loss of mobility can rangefrom decreased quality of life to, in some instances, life-threatening complications. By directly improving skeletal muscle function, a small moleculeactivator of the skeletal sarcomere potentially could enhance functional performance and quality of life in patients suffering from diseases or medicalconditions characterized or complicated by muscle weakness or wasting. These may include diseases and medical conditions associated with skeletal muscleweakness or wasting, such as ALS, claudication, myasthenia gravis, sarcopenia (general frailty associated with aging), post-surgical rehabilitation andcachexia in connection with heart failure or cancer.Tirasemtiv is our lead drug candidate from this program. We retain exclusive rights to tirasemtiv, subject to Astellas’ exercise of its Option onTirasemtiv. We conducted a Phase 2 clinical development program for tirasemtiv, and we started a Phase 3 clinical development program for this drugcandidate in patients with ALS in 8Table of ContentsJuly 2015. In collaboration with Astellas, we are also developing another drug candidate from this program, CK-2127107, for potential indications associatedwith muscle weakness. We started a Phase 2 clinical trial for CK-2127107 in patients with SMA in December 2015. Astellas, in collaboration withCytokinetics, started a Phase 2 clinical trial of CK-2127107 in patients with chronic obstructive pulmonary disease in June 2016. Tirasemtiv andCK-2127107 are structurally distinct and selective small molecules that activate the fast skeletal troponin complex in the sarcomere by increasing itssensitivity to calcium, leading to an increase in skeletal muscle contractility. Each of tirasemtiv and CK-2127107 has demonstrated pharmacological activityin preclinical models and evidence of potentially clinically relevant pharmacodynamic effects in humans. We are evaluating other potential indications forwhich tirasemtiv and CK-2127107 may be useful.TirasemtivTirasemtiv, a fast skeletal troponin activator, is the lead drug candidate from our skeletal muscle contractility program. We conducted three “evidenceof effect” Phase 2a clinical trials, and a Phase 2b clinical trial of tirasemtiv in patients with ALS. The evidence of effect clinical trials were randomized,double-blind, placebo-controlled, three-period cross-over studies of single doses of tirasemtiv administered to patients with impaired muscle function. Thesestudies were intended to translate the mechanism of action of tirasemtiv into potentially clinically relevant pharmacodynamic effects. The results from thePhase 2b clinical trial, BENEFIT-ALS, of tirasemtiv in patients with ALS showed that effects observed on slow vital capacity (“SVC”), a measure of thestrength of the skeletal muscles responsible for breathing, in patients treated with tirasemtiv were robust and potentially clinically meaningful and supportedfurther evaluation of tirasemtiv in a Phase 3 clinical trial.Tirasemtiv Clinical DevelopmentVITALITY-ALS: In July 2015, we started VITALITY-ALS, a Phase 3 clinical trial designed to assess the effects of tirasemtiv versus placebo on slowvital capacity and other measures of respiratory function in patients with ALS. VITALITY-ALS is designed to confirm and extend the results observed inBENEFIT-ALS.VITALITY-ALS is a multi-national, randomized, double-blind, placebo-controlled trial that was originally designed to enroll 445 patients withpossible, probable or definite ALS diagnosed within 24 months, and with a baseline vital capacity > 70 % of predicted, based on age, sex, and height.Patients may be enrolled whether, or not they are on riluzole therapy. The primary endpoint of the trial will assess change from baseline in SVC, to beassessed after 24 weeks of double-blind, placebo-controlled treatment. Secondary endpoints include time to decline from baseline in percent predicted SVCby 20 percentage points or the onset of respiratory insufficiency or death; time to decline from baseline in percent predicted SVC to £ 50 percent predictedor the onset of respiratory insufficiency or death; time to first occurrence of any use of assisted ventilation or death; time to decline in any of the threerespiratory domains of the ALSFRS-R or death; and change in the Mega-Score of muscle strength.Patients enrolled in VITALITY-ALS received two-weeks of open-label treatment with tirasemtiv administered at 250 mg/day and were randomized todouble-blind treatment with placebo or one of three target tirasemtiv dose levels (250 mg/day, 375 mg/day, 500 mg/day) in a 3:2:2:2 ratio for a total of 48weeks of randomized, double-blind, placebo-controlled treatment. Then in a four-week double-blind, tirasemtiv withdrawal phase, patients on tirasemtiv arerandomized either to continue the double-blind tirasemtiv dose they were receiving or to be withdrawn to placebo in a 1:1 ratio. Patients who had beenreceiving placebo during the 48 weeks of double-blind, placebo-controlled treatment will continue to receive placebo. VITALITY-ALS is being conducted in81 centers in 11 countries in North America and Europe and includes most of the sites which participated in BENEFIT-ALS.The design of VITALITY-ALS addresses certain observations from BENEFIT-ALS. VITALITY-ALS provides for a longer open label phase (one week inBENEFIT-ALS versus two weeks in VITALITY-ALS) prior 9Table of Contentsto patient randomization. The longer open label phase in VITALITY-ALS provides more time for patients to acclimate to potential side effects of tirasemtivto potentially reduce the rate of early termination on study medication post randomization as compared to BENEFIT-ALS. In addition, VITALITY-ALSrandomizes patients to three different target dose levels to evaluate the potential effect of dose on the safety, tolerability and efficacy of tirasemtiv. Patients inBENEFIT-ALS were randomized to one target dose level of 500 mg/day and investigators were encouraged to up-titrate patients to their maximally tolerateddose levels. In addition, in VITALITY-ALS, patients are up-titrated more slowly (two weeks at each dose level before up-titration in VITALITY-ALS versusone week in BENEFIT-ALS). We believe these and other design changes in VITALITY-ALS may decrease the rate of early terminations on tirasemtiv afterrandomization compared to the rate we observed after randomization in BENEFIT-ALS.In January 2016, we amended the protocol of VITALITY-ALS to provide for an increase in the number of patients to be enrolled in the clinical trialfrom approximately 445 patients to approximately 600 patients. Increasing the number of patients enrolled in VITALITY-ALS will increase the statisticalpower to detect a difference in the primary efficacy endpoint (change from baseline in SVC at 24 weeks) between tirasemtiv and placebo.In July 2015, we were awarded a $1.5 million grant from The ALS Association (the “ALSA Grant”) to support the conduct of VITALITY-ALS as well asthe collection of clinical data and plasma samples from patients in VITALITY-ALS in order to help advance the discovery of potentially useful biomarkers inALS. The grant provides funding for collaboration among Cytokinetics, The ALS Association and the Barrow Neurological Institute to enable plasmasamples collected from patients enrolled in VITALITY-ALS to be added to The Northeastern ALS Consortium (NEALS) Repository, a resource for theacademic research community to identify biomarkers that may help to assess disease progression and underlying disease mechanisms in ALS. In 2015,Cytokinetics achieved its first milestone under the ALSA Grant which triggered a payment of $0.5 million in accordance with the ALSA Grant. We recorded$0.1 million as grant revenue as qualified expenses were incurred and approved by management.In August 2016, we announced the completion of patient enrollment in VITALITY-ALS. We convened the second Data Monitoring CommitteeMeeting for VITALITY-ALS to review unblinded safety and efficacy data; and the Committee recommended continuing the trial without modifications to theprotocol.In October 2016, we initiated VIGOR-ALS (Ventilatory Investigations in Global Open-Label Research in ALS), an open-label extension clinical trialdesigned to assess the long-term safety and tolerability of tirasemtiv, in patients with ALS who have completed their participation in VITALITY-ALS.VIGOR-ALS will provide supplemental data on the effects of the long-term use of tirasemtiv.Prior Clinical Experience with TirasemtivBENEFIT-ALS: In 2012, we initiated BENEFIT-ALS, a Phase 2b, multi-national, double-blind, randomized, placebo-controlled, clinical trialdesigned to evaluate the safety, tolerability and efficacy of tirasemtiv in patients with ALS.In 2014, BENEFIT-ALS results were presented at the 66th Annual Meeting of the American Academy of Neurology. BENEFIT-ALS did not achieve itsprimary efficacy endpoint, the mean change from baseline in the ALS Functional Rating Scale in its revised form (ALSFRS-R; p = 0.11). Treatment withtirasemtiv resulted in a statistically significant and potentially clinically meaningful reduction in the decline of slow vital capacity (SVC), a measure of thestrength of the skeletal muscles responsible for breathing. SVC has been shown to be an important predictor of disease progression and survival in prior trialsof patients with ALS. At week 12, the decline in SVC from baseline was -3.12 for patients receiving tirasemtiv versus -8.66 for those receiving placebo (p <0.0001). From week 0 to week 12, the slope of decline in SVC measured as percentage points per day was -0.0394 for patients receiving tirasemtiv versus-0.0905 for those receiving placebo (p = 0.0006). 10Table of ContentsThe analyses of other pre-specified secondary efficacy endpoints in BENEFIT-ALS produced mixed results. The muscle strength mega-score, a measureof strength combining the data from several muscle groups in each patient, declined more slowly on tirasemtiv versus placebo. The difference in the rate ofdecline for sniff nasal inspiratory pressure (SNIP) was not statistically significant); however, SNIP decreased more on tirasemtiv compared with placebo in astatistically significant manner at 4 and 12 weeks. No differences in maximum voluntary ventilation and hand grip fatigue were observed on tirasemtiv versusplacebo.Serious adverse events (SAEs) during double-blind treatment were more frequent on tirasemtiv than on placebo (9.0% vs. 5.4%). The most commonSAE was respiratory failure which occurred in 1 patient on tirasemtiv and 3 patients on placebo. Confusional state and delirium occurred in 2 patients ontirasemtiv and no patients on placebo. More patients on tirasemtiv withdrew from the trial following randomization than on placebo (99 vs. 33 patients,respectively). Adverse events more common on tirasemtiv than on placebo (>10% difference) were dizziness, fatigue, and nausea.Tirasemtiv Presentations and PublicationsIn January 2016, in collaboration with Knopp Biosciences, we presented exploratory analyses of data from patients with ALS combined from threedifferent sources: First, the placebo data from EMPOWER, the Phase 3 clinical trial of Knopp’s dexpramipexole in patients with ALS, second, the placebodata from Cytokinetics’ Phase 2b study of tirasemtiv in patients with ALS, BENEFIT-ALS, and finally, Pooled Resource Open-Access ALS Clinical Trials(“PRO-ACT”) database. These combined databases included multiple observations of SVC over time from over 900 patients with ALS. Our analyses of thiscombined database demonstrated that the rate of decline of SVC predicts the risk of meaningful clinical events, including a decline in any one of the threerespiratory questions of the ALSFRS-R, as well as the time to the first occurrence of respiratory insufficiency, tracheostomy or death.In March 2016, we announced a research collaboration with Origent Data Sciences, Inc. (“Origent”) to refine and prospectively validate an Origentcomputer model to predict the course of ALS disease progression leveraging placebo data from Cytokinetics’ clinical trials of tirasemtiv and data from otherALS trials in the PRO-ACT database. Funded by Origent’s receipt of a grant from The ALS Association, this joint research program will enable the firstprospective validation of the predictive model in a clinical trial setting. The data presented showed that FVC measurements could be used to predict SVCvalues of ALS patients using a machine-based learning technique. Previously, the Origent models predicting both function and survival of ALS patients havebeen validated using their internal and retrospective external datasets.Also in March 2016, the results of BENEFIT-ALS were published in a manuscript titled, “A randomized, placebo-controlled, double-blind phase IIbtrial evaluating the safety and efficacy of tirasemtiv in patients with amyotrophic lateral sclerosis,” in the Amyotrophic Lateral Sclerosis and FrontotemporalDegeneration journal. Results from this trial were first presented at the Annual Meeting of the American Academy of Neurology in 2014.Tirasemtiv Strategic and Commercial PlanningIn 2016, we continued preparing for the potential commercialization of tirasemtiv in North America and Europe. These activities included interactionswith manufacturers, and corporate development and commercial planning activities to support various scenarios. We expect to continue to engageextensively with ALS experts, both neuromuscular and pulmonary, and with payors, regulatory authorities and patient advocacy groups as we develop plansfor the potential commercialization of tirasemtiv as a treatment for patients living with ALS. These commercialization plans will include market assessmentand corporate development activities to support the launch of tirasemtiv in North America and Europe, if appropriate.Background on ALS Market. Limited options exist for the treatment of patients with ALS, which affects as many as 30,000 Americans, with anestimated 5,600 new cases diagnosed each year in the U.S. Based on our 11Table of Contentsprimary market research, the per capita prevalence and incidence appears similar in the major European markets. ALS is 20% more common in men thanwomen; however, with increasing age, the prevalence becomes more equal between men and women. The life expectancy of an ALS patient averages two tofive years from the time of diagnosis, mostly due to respiratory issues. Of the patients diagnosed with ALS, 5 to 10% have a family history of the disease(familial ALS) and remaining 90 to 95% have the sporadic form. The majority of patients with ALS in the U.S. and Europe receive treatment at a concentratednumber of multidisciplinary centers that specialize in the unique needs of these patients. In the U.S., there are approximately 156 ALS multidisciplinaryclinics, according to either the ALS Association or the Muscular Dystrophy Association. For most patients with ALS, death is usually due to respiratoryfailure because of diminished strength in the skeletal muscles responsible for breathing. We believe that there is a need for novel therapies to address theurgent unmet medical issues of this patient population which could be addressed by a small, targeted sales force. If tirasemtiv is approved by regulatoryauthorities in the U.S. or Europe for commercialization for ALS, we believe that we may be able to independently commercialize tirasemtiv in theseconcentrated markets.CK-2127107 and Other Skeletal Muscle ActivatorsAstellas Strategic AllianceCK-2127107, a next-generation fast skeletal troponin activator, is being developed jointly by Cytokinetics and Astellas. In 2013, we formed acollaboration with Astellas with the primary objective of advancing novel therapies for diseases and medical conditions associated with muscle impairmentand weakness. Under the collaboration, we exclusively licensed to Astellas rights to co-develop and potentially co-commercialize CK-2127107 innon-neuromuscular indications. In 2014, we and Astellas agreed to expand the collaboration to include certain neuromuscular indications, including SMA,and to advance CK-2127107 into Phase 2 clinical development, initially in SMA. In connection with the expanded collaboration, we and Astellas agreed toextend the joint research program through 2016. In 2016, Cytokinetics and Astellas further amended the collaboration agreement to expand ourcollaboration to include the development of CK-2127107 for the potential treatment of ALS, as well as the possible development in ALS of other fast skeletalregulatory activators previously licensed by us to Astellas. The 2016 Astellas Amendment became effective in September 2016. The 2016 AstellasAmendment also extends the existing joint research program focused on the discovery of additional next-generation skeletal muscle activators through 2017,and includes sponsored research at Cytokinetics. Finally, under the 2016 Astellas Amendment, we granted Astellas the Option on Tirasemtiv, as describedabove.Addition of ALS as an Added Indication (CK-2127107 and other fast skeletal activators)In connection with the execution of the 2016 Astellas Amendment, we received a non-refundable upfront amendment fee of $35 million. In addition,we received an accelerated $15 million milestone payment that would have been payable upon the initiation of the first Phase 2 clinical trial of CK-2127107as the lead compound in ALS, as if such milestone had been achieved upon the execution of the 2016 Astellas Amendment.We and Astellas are collaborating to develop CK-2127107 in ALS. Astellas is primarily responsible for the development of CK-2127107 in ALS, butwe will conduct the Phase 2 clinical trial of CK-2127107 in ALS and will share in the operational responsibility for later clinical trials. Subject to specifiedguiding principles, decision making will be by consensus, subject to escalation and, if necessary, Astellas’ final decision making authority on thedevelopment (including regulatory affairs), manufacturing, medical affairs and commercialization of CK-2127107 and other fast skeletal regulatoryactivators in ALS. We and Astellas share equally the costs of developing CK-2127107 in ALS for potential registration and marketing authorization in theU.S. and Europe, provided that (i) Astellas has agreed to solely fund Phase 2 development costs of CK-2127107 in ALS subject to a right to recoup our shareof such costs plus a 100% premium by reducing future milestone and royalty payments to us and (ii) we may defer (but not eliminate) a portion of ourco-funding obligation for development activities after Phase 2 for up to 18 months, subject to certain conditions. We have the right to co-fund our share ofsuch Phase 2 development costs on a current basis, in which case there would not be a premium due to 12Table of ContentsAstellas. Cytokinetics will also receive approximately $41.8 million in additional sponsored research and development funding through 2018 whichincludes Astellas’ funding of Cytokinetics’ conduct of the Phase 2 clinical development of CK-2127107 in ALS (approximately $36.6 million) as well as thecontinuing research collaboration (approximately $5.2 million).Based on the achievement of pre-specified criteria, Cytokinetics may receive over $600.0 million in milestone payments relating to the developmentand commercial launch of collaboration products, including up to $112.0 million (of which Cytokinetics has now received $17.0 million) relating to earlydevelopment of CK-2127107 and for later-stage development and commercial launch milestones for CK-2127107 in non-neuromuscular indications, andover $100.0 million in development and commercial launch milestones for CK-2127107 in each of SMA and other neuromuscular indications. Cytokineticsmay also receive up to $200.0 million in payments for achievement of pre-specified sales milestones related to net sales of all collaboration products underthe Current Astellas Agreement. If Astellas commercializes any collaboration products, we will also receive royalties on sales of such collaboration products,including royalties ranging from the high single digits to the high teens on sales of products containing CK-2127107. We can co-fund certain developmentcosts for CK-2127107 and other compounds in exchange for increased milestone payments and royalties; such royalties may increase under certain scenariosto exceed twenty percent. In addition to the foregoing development, commercial launch and sales milestones, Cytokinetics may also receive payments for theachievement of pre-specified milestones relating to the joint research program.Cytokinetics retains an option to conduct early-stage development for certain agreed indications at its initial expense, subject to reimbursement ifdevelopment continues under the collaboration. Cytokinetics also retains an option to co-promote collaboration products containing fast skeletal troponinactivators for neuromuscular indications in the U.S., Canada and Europe, in addition to its option to co-promote other collaboration products in the U.S. andCanada. Astellas will reimburse Cytokinetics for certain expenses associated with its co-promotion activities.In December 2014, we and Astellas entered into the 2014 Astellas Agreement pursuant to which we received a non-refundable upfront payment of$30.0 million. Concurrently, we entered into a common stock purchase agreement with Astellas, which provided for the sale of 2,040,816 shares of ourcommon stock to Astellas at a price per share of $4.90 and an aggregate purchase price of $10.0 million. Pursuant to this agreement, Astellas agreed to certaintrading and other restrictions with respect to our common stock. Concurrently, Cytokinetics earned a $15.0 million milestone payment relating to Astellas’decision to advance CK-2127107 into Phase 2 clinical development. Cytokinetics was also eligible to potentially receive over $20.0 million inreimbursement of sponsored research and development activities during the two years of the collaboration following the execution of the 2014 AstellasAgreement.CK-2127107 Clinical DevelopmentSMA Clinical Development: Cytokinetics in collaboration with Astellas is conducting a Phase 2 clinical development program. Cytokinetics started aPhase 2 clinical trial of CK-2127107 in patients with SMA (CY 5021) in December 2015. The clinical trial is designed to assess effects of CK-2127107 onmultiple measures of muscle function in both ambulatory and non-ambulatory patients with SMA, a severe, genetic neuromuscular disease that leads todebilitating muscle wasting and progressive, often fatal, muscle weakness. The primary objective of this double-blind, randomized, placebo-controlledclinical trial is to determine the potential pharmacodynamic effects of a suspension formulation of CK-2127107 following multiple oral doses in patientswith Type II, Type III, or Type IV SMA. Secondary objectives are to evaluate the safety, tolerability and pharmacokinetics of CK-2127107. The trial willenroll seventy-two patients in two sequential, ascending dose cohorts (two cohorts of 36 patients each, stratified half ambulatory and half non-ambulatory).The first cohort of patients received 150 mg of CK-2127107 dosed twice daily for eight weeks; the second cohort of patients will receive 450 mg ofCK-2127107 dosed twice daily or a lower dose, depending on the data 13Table of Contentsfrom the first cohort. At the conclusion of the trial, approximately 24 patients will have been randomized to placebo, approximately 24 patients to 150 mg ofCK-2127107 twice daily and approximately 24 patients to 450 mg of CK-2127107 twice daily (or a lower dose, pending the review of data from the firstcohort). In each of these three treatment groups of approximately 24 patients each, roughly half will be ambulatory and half will be non-ambulatory. Multipleassessments of skeletal muscle function and fatigability will be performed including respiratory assessments, upper limb strength and functionality fornon-ambulatory patients, as well as six-minute walk and timed-up-and-go for ambulatory patients.We continue enrollment patients with SMA in this Phase 2 clinical trial, in collaboration with Astellas. We anticipate that the trial will completeenrollment and report data in the second half of 2017.COPD Clinical Development: In June 2016, Astellas, in collaboration with Cytokinetics, started a Phase 2 clinical trial of CK-2127107 in patients withCOPD. Astellas is conducting this randomized, double-blind, placebo controlled two period crossover clinical trial designed to assess the effect ofCK-2127107 on physical function in patients with COPD. The trial is expected to enroll approximately 40 patients in the United States and is designed toassess the effect of CK-2127107 compared to placebo on exercise tolerance. Additionally, the trial will assess the cardiopulmonary and neuromuscular effectof CK-2127107 relative to placebo and the effect of CK-2127107 on resting spirometry relative to placebo. The safety, tolerability and pharmacokinetics ofCK-2127107 also will be assessed. We expect Astellas to continue enrollment in this Phase 2 clinical trial of CK-2127107 in patients with COPD in 2017.ALS Clinical Development: We anticipate that we will begin a Phase 2 clinical trial of CK-2127107 in patients with ALS mid-2017.Frailty Clinical Development: We anticipate that Astellas will begin a Phase 1b clinical trial of CK-2127107 in elderly patients with limited mobilityin the first half of 2017.Prior Clinical Experience with CK-2127107We completed five Phase 1 clinical trials evaluating safety, tolerability and pharmacokinetics and pharmacodynamics of CK-2127107 in both oraltablet and liquid suspension formulations in healthy volunteers. The Phase 1 clinical trials demonstrated that CK-2127107 appeared well-tolerated in healthyvolunteers and that exposures generally increased across the dose ranges studied. CK-2127107 increased the response of muscle to neuromuscular input in adose and plasma concentration related fashion in healthy volunteers consistent with preclinical observations.CK-2127107 Commercial MarketBackground on SMA Market: Spinal muscular atrophy (“SMA”) is a severe neuromuscular disease that occurs in 1 in every 6,000 to 10,000 livebirths each year resulting in a prevalence of 10,000 to 25,000 patients in the U.S., and is one of the most common fatal genetic disorders. SMA manifests invarious degrees of severity as progressive muscle weakness resulting in respiratory and mobility impairment. There are four types of SMA, distinguished bythe time of the initial onset of muscle weakness and the severity of related symptoms: Type I (severe), Type II (intermediate), Type III (juvenile) and Type IV(adult onset). Life expectancy and disease severity varies by type of SMA from Type I, who have the worst prognosis and a life expectancy of approximatelytwo years from birth, to Type IV, who have a normal life span but with gradual weakness in the proximal muscles of the extremities resulting in mobilityissues. Type II, III and IV patients are often characterized by their ambulatory status as it is an important driver of clinical decisions and care, and constitute50% of the incident patient population but as much as 90% of the prevalent patient population. Few treatment options exist for these patients, resulting in ahigh unmet need for new therapeutic options to ameliorate symptoms, improve muscle function and modify disease progression. 14Table of ContentsOngoing Research in Skeletal Muscle ActivatorsOur research on the direct activation of skeletal muscle continues in two areas. We are conducting translational research in preclinical models ofdisease and muscle function with fast skeletal troponin activators to explore the potential clinical applications of this novel mechanism in diseases orconditions associated with skeletal muscle dysfunction. We also intend to conduct preclinical research on other chemically and pharmacologically distinctmechanisms to activate the skeletal sarcomere.We advanced a next-generation skeletal muscle activator into IND-enabling studies in 2016 and earned a $2.0 million milestone payment. We areconducting a joint research program with Astellas directed to the discovery of next-generation skeletal muscle activators. Under the 2016 AstellasAmendment, the joint research program will continue through 2017 and Astellas will reimburse us for certain research activities we perform.Cardiac Muscle Contractility ProgramOverviewOur cardiac muscle contractility program is focused on the cardiac sarcomere, the basic unit of muscle contraction in the heart. The cardiac sarcomere isa highly ordered cytoskeletal structure composed of cardiac muscle myosin, actin and a set of regulatory proteins. This program is currently directed towardsthe discovery and development of small molecule cardiac muscle myosin activators with the goal of developing novel drugs to treat acute and chronic heartfailure. Cardiac muscle myosin is the cytoskeletal motor protein in the cardiac muscle cell. It is directly responsible for converting chemical energy into themechanical force, resulting in cardiac muscle contraction. This program is based on the hypothesis that activators of cardiac muscle myosin may addresscertain adverse properties of existing positive inotropic agents. Current positive inotropic agents, such as beta-adrenergic receptor agonists or inhibitors ofphosphodiesterase activity, increase the concentration of intracellular calcium, thereby increasing cardiac sarcomere contractility. The effect on calciumlevels, however, also has been linked to potentially life-threatening side effects. In contrast, our novel cardiac muscle myosin activators work by a mechanismthat directly stimulates the activity of the cardiac muscle myosin motor protein, without increasing the intracellular calcium concentration. They acceleratethe rate-limiting step of the myosin enzymatic cycle and shift it in favor of the force-producing state. Rather than increasing the velocity of cardiaccontraction, this mechanism instead lengthens the systolic ejection time, which results in increased cardiac function in a potentially more oxygen-efficientmanner.Amgen Strategic Alliance.In December 2006, we entered into a collaboration and option agreement with Amgen to discover, develop and commercialize novel small moleculetherapeutics, including omecamtiv mecarbil, that activate cardiac muscle contractility for potential applications in the treatment of heart failure (the “AmgenAgreement”). The agreement granted Amgen an option to obtain an exclusive license worldwide, except Japan, to develop and commercialize omecamtivmecarbil and other drug candidates arising from the collaboration. In May 2009, Amgen exercised its option. As a result, Amgen became responsible for thedevelopment and commercialization of omecamtiv mecarbil and related compounds at its expense worldwide (excluding Japan), subject to our developmentand commercialization participation rights. Amgen reimburses us for certain research and development activities we perform under the collaboration.In June 2013, Cytokinetics and Amgen executed an amendment to the Amgen Agreement to include Japan, resulting in a worldwide collaboration (the“Amgen Agreement Amendment”). Under the terms of the Amgen Agreement Amendment, we received a non-refundable upfront license fee of $15.0 millionin June 2013. Under the Amgen Agreement Amendment, we conducted a Phase 1 pharmacokinetic study intended to support inclusion of Japan in a potentialPhase 3 clinical development program and potential global registration dossier for omecamtiv mecarbil. Amgen reimbursed us for the costs of this study. Inaddition, we are eligible to receive additional pre-commercialization milestone payments relating to the development of omecamtiv mecarbil in 15Table of ContentsJapan of up to $50.0 million, and royalties on sales of omecamtiv mecarbil in Japan. In conjunction with the Amgen Agreement Amendment, we also enteredinto a common stock purchase agreement which provided for the sale of 1,404,100 shares of our common stock to Amgen at a price per share of $7.12 and anaggregate purchase price of $10.0 million which was received in June 2013. Pursuant to this agreement, Amgen agreed to certain trading and otherrestrictions with respect to our common stock.Under the Amgen Agreement as amended we are eligible for potential additional pre-commercialization and commercialization milestone payments ofover $600.0 million in the aggregate on omecamtiv mecarbil and other potential products arising from research under the collaboration, and royalties thatescalate based on increasing levels of annual net sales of products commercialized under the agreement. The Amgen Agreement also provides for us toreceive increased royalties by co-funding Phase 3 development costs of omecamtiv mecarbil and other drug candidates under the collaboration. In February2017, we agreed to exercise our option to co-invest $40.0 million in the Phase 3 development program of omecamtiv mecarbil. As a result, we are eligible toreceive an incremental royalty of up to 4% on increasing worldwide sales of omecamtiv mecarbil outside of Japan. Exercising and fully co-funding ouroption will afford us the right to co-promote omecamtiv mecarbil in institutional care settings in North America, with reimbursement by Amgen for certainsales force activities.In July 2013, Amgen announced that it had granted an option to commercialize omecamtiv mecarbil in Europe to Servier, with Cytokinetics’ consent,pursuant to an Option, License and Collaboration Agreement (the “Servier Agreement”).In August 2016, we entered into a Letter Agreement with Amgen and Servier (the “Letter Agreement”), which (i) expands the territory of the sublicenseto Servier to include specified countries in the CIS, including Russia and (ii) provides that, if Amgen’s rights under the Amgen Agreement, as amended, areterminated with respect to the territory of such sublicense, the sublicensed rights previously granted by Amgen to Servier under the Servier Agreement willremain in effect and become a direct license or sublicense of such rights by us to Servier, on substantially the same terms as set forth in the Servier Agreement,including but not limited to Servier’s payment of its share of agreed development costs and future milestone and royalty payments to us. The LetterAgreement does not otherwise modify our rights and obligations under the Amgen Agreement, as amended, or create any additional financial obligations ofCytokinetics, unless we otherwise agree in writing.In September 2016, Amgen and Servier announced Servier’s decision to exercise its option to commercialize omecamtiv mecarbil in Europe as well asthe CIS, including Russia. The option and related commercialization sublicense to Servier is subject to the terms and conditions of the Amgen Agreement.Amgen remains responsible for the performance of its obligations under the Amgen Agreement, as amended, relating to Europe and the CIS, including thepayment of milestones and royalties relating to the development and commercialization of omecamtiv mecarbil in Europe and the CIS.Omecamtiv MecarbilOur lead drug candidate from this program is omecamtiv mecarbil, a novel cardiac muscle myosin activator. We expect omecamtiv mecarbil to bedeveloped as a potential treatment across the continuum of care in heart failure both for use in the hospital setting and for use in the outpatient setting.Omecamtiv Mecarbil Clinical DevelopmentGALACTIC-HF is a Phase 3 cardiovascular outcomes clinical trial of omecamtiv mecarbil which is being conducted by Amgen, in collaboration withCytokinetics. Coincident with the start of the trial, Amgen made a $26.7 million milestone payment to Cytokinetics. The primary objective of this double-blind, randomized, placebo-controlled multicenter clinical trial is to determine if treatment with omecamtiv mecarbil when added to standard of care issuperior to standard of care plus placebo in reducing the risk of cardiovascular death or heart failure events in patients with high risk chronic heart failure andreduced ejection fraction. GALACTIC-HF is 16Table of Contentsbeing conducted under a Special Protocol Assessment (“SPA”) with the U.S. FDA. GALACTIC-HF is planned to enroll approximately 8,000 symptomaticchronic heart failure patients in over 900 sites in 35 countries who are either currently hospitalized for a primary reason of heart failure or have had ahospitalization or admission to an emergency room for heart failure within one year prior to screening. In order to be eligible to participate in GALACTIC-HFpatients should have an LVEF £ 35%, be NYHA class II to IV, and have an elevated BNP or NT-proBNP. Patients will be randomized to either placebo oromecamtiv mecarbil with dose titration up to a maximum dose of 50 mg twice daily based on the plasma concentration of omecamtiv mecarbil after initiationof drug therapy. The primary endpoint is a composite of time to cardiovascular death or first heart failure event, which is defined as either a hospitalizationfor heart failure or other urgent treatment for worsening heart failure. Secondary endpoints include time to cardiovascular death; patient reported outcomes asmeasured by the Kansas City Cardiomyopathy Questionnaire Total Symptom Score; time to first heart failure hospitalization; and all-cause death.Cytokinetics and Amgen are also planning a potential exercise performance/cardiac function clinical trial to be conducted by Cytokinetics. Amgenwill be responsible for reimbursing us for the out-of-pocket development costs associated with this clinical trial.In April 2016, we announced the start of a Phase 2 clinical trial of omecamtiv mecarbil in Japanese subjects with chronic heart failure and reducedejection fraction and we expect data from this trial in Q3 2017.Prior Clinical Experience with Omecamtiv MecarbilCOSMIC-HF. COSMIC-HF is a Phase 2, double-blind, randomized, placebo-controlled, multicenter, clinical trial designed to assess thepharmacokinetics and tolerability of omecamtiv mecarbil dosed orally in patients with heart failure and left ventricular systolic dysfunction as well as itseffects on echocardiographic measures of cardiac function. COSMIC-HF was conducted by Amgen in collaboration with Cytokinetics. The study began withtwo dose escalation cohorts of 40 patients each, randomized 1:1:1:1 to placebo or one of three different modified release oral formulations of omecamtivmecarbil for seven days. The omecamtiv mecarbil dose in the first of these two dose escalation cohorts was 25 mg twice daily; in the second, it was 50 mgtwice daily. The purpose of the dose escalation cohorts was to select one of the three modified release oral formulations of omecamtiv mecarbil for furtherevaluation in a larger group of patients treated for a longer period of time.The expansion phase of COSMIC-HF was designed to evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of the modifiedrelease oral formulation omecamtiv mecarbil selected based on the results of the two dose escalation cohorts in 448 patients with chronic heart failure and leftventricular systolic dysfunction. Patients were randomized 1:1:1 to receive either placebo or treatment with omecamtiv mecarbil 25 mg twice daily or a dosetitration group where 25 mg twice daily dosing could be increased to 50 mg twice daily depending on plasma concentrations of omecamtiv mecarbil aftertwo weeks of treatment with the 25 mg dose.In November 2015, we announced the results from the expansion phase of COSMIC-HF (Chronic Oral Study of Myosin Activation to IncreaseContractility in Heart Failure) that were presented at the American Heart Association Scientific Sessions 2015 in Orlando, Florida. Data from the expansionphase showed that dose titration controlled patient exposure to omecamtiv mecarbil. Approximately 60 percent of patients in the dose titration groupescalated dosing to 50 mg twice daily. The study met its primary pharmacokinetics objective.Following 20 weeks of treatment, statistically significant improvements were observed in pre-specified secondary endpoint measures of cardiacfunction in the dose titration group, compared to placebo. Systolic ejection time increased by 25.0 msec (p<0.001), stroke volume increased by 3.63 mL(p=0.022) and heart rate decreased by 2.97 beats per min (p=0.007). Left ventricular end-systolic and end-diastolic dimensions decreased by 1.79 mm(p=0.003) and 1.29 mm (p=0.013), respectively, and were associated with statistically significant reductions in left ventricular end-systolic and end-diastolicvolumes. N-terminal pro-brain natriuretic peptide (NT-proBNP) decreased by 970 pg/mL (p=0.007). Additionally, in the 25 mg twice daily group, there were 17Table of Contentsstatistically significant increases in systolic ejection time and stroke volume and a decrease in NT-proBNP. All changes are from baseline compared toplacebo. The pharmacodynamic effects of omecamtiv mecarbil were generally dose dependent and larger in patients that received oral dosing with 50 mgtwice daily.Adverse events (AEs), including serious AEs, in patients on omecamtiv mecarbil were comparable to placebo. The incidence of adjudicated deaths(2.7 percent died on placebo, 1.4 percent died on omecamtiv mecarbil), myocardial infarction (1.34 percent on placebo, 0.34 percent on omecamtiv mecarbil)and unstable angina (0 percent on placebo, 0.34 percent on omecamtiv mecarbil) was similar. Other cardiac AEs were generally balanced between placeboand active treatment groups. In the omecamtiv mecarbil groups, compared to placebo, cardiac troponin increased by 0.001 ng/mL and 0.006 ng/mL (medianchange from baseline at week 20) in the 25 mg twice daily group and dose titration group, respectively. Events of increased troponin (n=278 across alltreatment groups) were independently adjudicated and none were determined to be myocardial ischemia or infarction.ATOMIC-AHF. ATOMIC-AHF (Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure) was an international,randomized, double-blind, placebo-controlled, Phase 2b clinical trial of intravenous omecamtiv mecarbil in patients with left ventricular systolic dysfunctionhospitalized with acutely decompensated heart failure, completed in 2013. The primary efficacy endpoint of dyspnea symptom response was not met;however, the study demonstrated favorable trends between the dose and plasma concentration of omecamtiv mecarbil and dyspnea response. Rates of adverseevents (AEs), serious AEs, adjudicated deaths and hospitalizations were similar between omecamtiv mecarbil and placebo groups. Omecamtiv mecarbil wasnot associated with an increased incidence of tachyarrhythmias nor were heart rate or blood pressure adversely affected.Nine Phase 1 clinical trials of omecamtiv mecarbil have been conducted in healthy subjects: five conducted by Cytokinetics and four conducted byAmgen in collaboration with Cytokinetics. Cytokinetics has also conducted two Phase 2a clinical trials of omecamtiv mecarbil. These clinical trials weredesigned to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of both intravenous and oral formulations in a diversity ofpatients, including patients with stable heart failure and patients with ischemic cardiomyopathy. In these trials, omecamtiv mecarbil exhibited generallylinear, dose-proportional pharmacokinetics across the dose ranges studied. The adverse effects observed at intolerable doses in humans appeared similar tothe adverse findings which occurred in preclinical safety studies at similar plasma concentrations. These effects are believed to be related to the mechanism ofaction of this drug candidate which, at intolerable doses, resulted in an excessive prolongation of the systolic ejection time (i.e., the time in which the heart iscontracting). However, these effects resolved promptly with discontinuation of the infusions of omecamtiv mecarbil.Ongoing Research in Cardiac Muscle Contractility. We continued our joint research program with Amgen directed to next-generation compounds in our cardiac muscle contractility program in 2016. Weexpect to continue our joint research program with Amgen in 2017. Under the Amgen Agreement, Amgen reimburses us for certain research activities weperform.Presentations and PublicationsIn March 2016, the manuscript, “Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure, The ATOMIC-AHFStudy,” was published in the Journal of the American College of Cardiology. Results from this trial were first presented at the European Society ofCardiology Meeting in 2013.In September 2016, additional results from COSMIC-HF were presented in a Rapid Fire Abstract Session at the Heart Failure Society of AmericaScientific Meeting in Orlando, Florida. The results showed that omecamtiv mecarbil may improve symptoms in patients with moderate to severe heart failuresymptoms versus placebo after 20 weeks of double-blind treatment, as measured by the Kansas City Cardiomyopathy Questionnaire Total 18Table of ContentsSymptom Score (TSS), one of the sub-domains of a self-administered questionnaire that measures quality-of-life in patients with heart failure. At week 20, theTSS was increased (with increases in the score reflecting improvement) in a dose-related fashion, with a 4.9 point improvement in the PK-guided dosetitration group (p=0.03). This improvement was greater among patients who were moderately to severely symptomatic at baseline, with the largest magnitudein the PK-guided dose titration treatment group (6.5, p=0.09). Patients who were asymptomatic or mildly symptomatic had modest improvements in the TSS.In November 2016, the results from COSMIC-HF were published in The Lancet. Results from this trials were first presented at a Late-Breaking ClinicalTrial session at the American Heart Association (AHA) Scientific Sessions in 2015.Omecamtiv Mecarbil Heart Failure MarketBackground on Heart Failure Market. Heart failure is a widespread and debilitating syndrome affecting millions of people in the United States. Thehigh and rapidly growing prevalence of heart failure translates into significant hospitalization rates and associated societal costs. About 6.4 million people inthe United States have heart failure, resulting in nearly one million hospital discharges with the primary diagnosis of heart failure and approximately 300,000deaths each year. For people over 65 years of age, heart failure incidences approach 10 per 1000 and approximately 50% of people diagnosed with heartfailure will die within 5 years of diagnosis. These numbers are increasing due to the aging of the U.S. population and an increased likelihood of survivalfollowing acute myocardial infarctions. The costs to society attributable to the prevalence of heart failure are high, especially as many chronic heart failurepatients suffer repeated acute episodes. Despite currently available therapies, readmission rates for heart failure patients remain high. In general, the mortalityfollowing hospitalization for patients with heart failure is 10.4% at 30 days, 22% at one year and 42.3% at 5 years, despite the availability of therapeuticalternatives for treatment of these patients. These poor outcomes in the setting of current therapies points to the need for novel therapeutics that may offerfurther reductions in morbidity and mortality. The annual cost of heart failure to the U.S. health care system is estimated to be $32 billion and is predicted togrow 120% to almost $70 billion by the year 2030. Today, a portion of that cost is attributable to drugs used to treat each of chronic and acute heart failure.Approximately 70% of those costs are due to hospitalization, home health and physician care. In the U.S., Medicare is one of the largest payors for heartfailure related costs. Approximately 50% of Medicare beneficiaries with heart failure are concentrated in the top 20% of the hospital referral regions in theU.S. New drug therapies that could reduce the number of hospitalizations could decrease the cost to the health care system.Beyond Muscle ContractilityWe developed preclinical expertise in the mechanics of skeletal, cardiac and smooth muscle that extends from proteins to tissues to intact animalmodels. Our translational research in muscle contractility has enabled us to better understand the potential impact of small molecule compounds that increaseskeletal or cardiac muscle contractility and to apply those findings to the further evaluation of our drug candidates in clinical populations. In addition tocontractility, other major functions of muscle play a role in certain diseases that could benefit from novel mechanism treatments. Accordingly, our knowledgeof muscle contractility may serve as an entry point to the discovery of novel treatments for disorders involving muscle functions other than musclecontractility. We are leveraging our current understandings of muscle biology to investigate new ways of modulating these other aspects of muscle functionfor other potential therapeutic applications.Intellectual PropertyOur policy is to seek patent protection for the technologies, inventions and improvements that we develop that we consider important to theadvancement of our business. As of December 31, 2016, we owned or co-owned or licensed 87 issued U.S. patents, over 310 issued patents in various foreignjurisdictions, and over 190 additional pending U.S. and foreign patent applications. We also rely on trade secrets, technical know-how 19Table of Contentsand continuing innovation to develop and maintain our competitive position. Our commercial success will depend on obtaining and maintaining patentprotection and trade secret protection for our drug candidates and technologies and our successfully defending these patents against third-party challenges.We will only be able to protect our technologies from unauthorized use by third parties to the extent that valid and enforceable patents cover them or wemaintain them as trade secrets.With regard to our drug candidates directed to muscle biology targets, we have a U.S. patent covering omecamtiv mecarbil and U.S. patents coveringour skeletal muscle sarcomere activators including, but not limited to, tirasemtiv and CK-2127107, each of which will expire in 2027, 2027 and 2031,respectively, unless extended or otherwise adjusted. We also have issued patents in various foreign jurisdictions and additional U.S. and foreign patentapplications pending for each of our drug candidates. It is not known or determinable whether other patents will issue from any of our other pendingapplications or what the expiration dates would be for any other patents that do issue.All of our drug candidates are still in clinical development and have not yet been approved by the FDA. If any of these drug candidates is approved,then pursuant to federal law, we may apply for an extension of the U.S. patent term for one patent covering the approved drug, which could extend the term ofthe applicable patent by up to a maximum of five additional years.The degree of future protection of our proprietary rights is uncertain because legal means may not adequately protect our rights or permit us to gain orkeep our competitive advantage. Due to evolving legal standards relating to the patentability, validity and enforceability of patents covering pharmaceuticalinventions and the claim scope of these patents, our ability to enforce our existing patents and to obtain and enforce patents that may issue from any pendingor future patent applications is uncertain and involves complex legal, scientific and factual questions. The standards that the U.S. Patent and TrademarkOffice and its foreign counterparts use to grant patents are not always applied predictably or uniformly and are subject to change. To date, no consistentpolicy has emerged regarding the breadth of claims allowed in biotechnology and pharmaceutical patents. Thus, we cannot be sure that any patents will issuefrom any pending or future patent applications owned by or licensed to us. Even if patents do issue, we cannot be sure that the claims of these patents will beheld valid or enforceable by a court of law, will provide us with any significant protection against competitive products, or will afford us a commercialadvantage over competitive products. For example: • we or our licensors might not have been the first to make the inventions covered by each of our pending patent applications and issued patents; • we or our licensors might not have been the first to file patent applications for the inventions covered by our pending patent applications and issuedpatents; • others may independently develop similar or alternative technologies or duplicate any of our technologies without infringing our intellectualproperty rights; • some or all of our or our licensors’ pending patent applications may not result in issued patents or the claims that issue may be narrow in scope andnot provide us with competitive advantages; • our and our licensors’ issued patents may not provide a basis for commercially viable drugs or therapies or may be challenged and invalidated bythird parties; • our or our licensors’ patent applications or patents may be subject to interference, opposition or similar administrative proceedings that may resultin a reduction in their scope or their loss altogether; • we may not develop additional proprietary technologies or drug candidates that are patentable; or • the patents of others may prevent us or our partners from discovering, developing or commercializing our drug candidates.The defense and prosecution of intellectual property infringement suits, interferences, oppositions and related legal and administrative proceedings arecostly, time-consuming to pursue and divert resources. The outcome of these types of proceedings is uncertain and could significantly harm our business. 20Table of ContentsOur ability to commercialize drugs depends on our ability to use, manufacture and sell those drugs without infringing the patents or other proprietaryrights of third parties. U.S. and foreign issued patents and pending patent applications owned by third parties exist that may be relevant to the therapeuticareas and chemical compositions of our drug candidates. While we are aware of certain relevant patents and patent applications owned by third parties, theremay be issued patents or pending applications of which we are not aware that could cover our drug candidates. Because patent applications are often notpublished immediately after filing, there may be currently pending applications, unknown to us, which could later result in issued patents that our activitieswith our drug candidates could infringe.The development of our drug candidates and the commercialization of any resulting drugs may be impacted by patents of companies engaged incompetitive programs with significantly greater resources. This could result in the expenditure of significant legal fees and management resources.We also rely on trade secrets to protect our technology, especially where we do not believe patent protection is appropriate or obtainable. However,trade secrets are often difficult to protect, especially outside of the United States. While we believe that we use reasonable efforts to protect our trade secrets,our employees, consultants, contractors, partners and other advisors may unintentionally or willfully disclose our trade secrets to competitors. Enforcing aclaim that a third party illegally obtained and is using our trade secrets would be expensive and time-consuming, and the outcome would be unpredictable.Even if we are able to maintain our trade secrets as confidential, our competitors may independently develop information that is equivalent or similar to ourtrade secrets.We seek to protect our intellectual property by requiring our employees, consultants, contractors and other advisors to execute nondisclosure andinvention assignment agreements upon commencement of their employment or engagement, through which we seek to protect our intellectual property.Agreements with our employees also preclude them from bringing the proprietary information or materials of third parties to us. We also requireconfidentiality agreements or material transfer agreements from third parties that receive our confidential information or materials.For further details on the risks relating to our intellectual property, please see the risk factors under Item 1A of this report, including, but not limited to,the risk factors entitled “Our success depends substantially upon our ability to obtain and maintain intellectual property protection relating to our drugcandidates and research technologies” and “If we are sued for infringing third party intellectual property rights, it will be costly and time-consuming, and anunfavorable outcome would have a significant adverse effect on our business.”Government RegulationThe FDA and comparable regulatory agencies in state and local jurisdictions and in foreign countries impose substantial requirements upon theclinical development, manufacture, marketing and distribution of drugs. These agencies and other federal, state and local entities regulate research anddevelopment activities and the testing, manufacture, quality control, labeling, storage, record keeping, approval, advertising and promotion of our drugcandidates and drugs.In the United States, the FDA regulates drugs under the Federal Food, Drug and Cosmetic Act and implementing regulations. The process required bythe FDA before our drug candidates may be marketed in the United States generally involves the following: • completion of extensive preclinical laboratory tests, preclinical animal studies and formulation studies, all performed in accordance with the FDA’sgood laboratory practice regulations; • submission to the FDA of an investigational new drug application (“IND”), which must become effective before clinical trials may begin; 21Table of Contents • performance of adequate and well-controlled clinical trials to establish the safety and efficacy of the drug candidate for each proposed indication inaccordance with good clinical practices; • submission of a new drug application (“NDA”) to the FDA, which must usually be accompanied by payment of a substantial user fee; • satisfactory completion of an FDA preapproval inspection of the manufacturing facilities at which the product is produced to assess compliancewith current good manufacturing practice (“cGMP”) regulations and FDA audits of select clinical investigator sites to assess compliance with goodclinical practices (“GCP”); and • FDA review and approval of the NDA prior to any commercial marketing, sale or shipment of the drug.Similar regulatory procedures generally apply in countries outside of the United States. This testing and approval process requires substantial time,effort and financial resources, and we cannot be certain that any approvals for our drug candidates will be granted on a timely basis, if at all.Nonclinical tests include laboratory evaluation of product chemistry, formulation and stability, and studies to evaluate toxicity and pharmacokineticsin animals. The results of nonclinical tests, together with manufacturing information and analytical data, are submitted as part of an IND application to theFDA. The IND automatically becomes effective 30 days after receipt by the FDA, unless the FDA, within the 30-day period, raises concerns or questions aboutthe conduct of the clinical trial, including concerns that human research subjects may be exposed to unreasonable health risks. In such a case, the INDsponsor and the FDA must resolve any outstanding concerns before the clinical trial can begin. Our submission of an IND or a foreign equivalent, or those ofour collaborators, may not result in authorization from the FDA or its foreign equivalent to commence a clinical trial. A separate submission to an existingIND must also be made for each successive clinical trial conducted during product development. Further, an independent institutional review board (“IRB”)or its foreign equivalent for each medical center proposing to conduct the clinical trial must review and approve the plan for any clinical trial before itcommences at that center and it must monitor the clinical trial until completed. The FDA, the IRB or their foreign equivalents, or the clinical trial sponsormay suspend a clinical trial at any time on various grounds, including a finding that the subjects or patients are being exposed to an unacceptable health risk.Clinical Trials. For purposes of an NDA or equivalent submission and approval, clinical trials are typically conducted in the following threesequential phases, which may overlap: • Phase 1: Phase 1 includes the initial introduction of a drug candidate into humans. These studies may be conducted in patients, but are usuallyconducted in healthy volunteer subjects. These studies are designed to determine the metabolic and pharmacologic actions of the drug candidate inhumans, the side effects associated with increasing doses, and, if possible, to gain early evidence on effectiveness. During Phase 1, sufficientinformation about the drug candidate’s pharmacokinetics and pharmacological effects should be obtained to permit the design of well-controlled,scientifically valid, Phase 2 trials. • Phase 2: Phase 2 includes the early controlled clinical studies conducted to obtain some preliminary data on the effectiveness of the drugcandidate for a particular indication or indications in patients with the disease or condition. This phase of testing also helps determine the commonshort-term side effects and risks associated with the drug candidate. These clinical trials are generally conducted in a limited patient population toidentify possible adverse effects and safety risks, to make an initial determination of potential efficacy of the drug candidate for specific targetedindications and to determine dose tolerance and optimal dosage. Multiple Phase 2 clinical trials may be conducted by the sponsor to obtaininformation prior to beginning larger and more expensive Phase 3 clinical trials. Phase 2a clinical trials generally are designed to study thepharmacokinetic or pharmacodynamic properties and to conduct a preliminary assessment of safety of the drug candidate over a measured doseresponse range. In some cases, a sponsor may decide to conduct a Phase 2b clinical trial, which is a second, typically larger, 22Table of Contents confirmatory Phase 2 trial that could, if positive and accepted by a regulatory authority, support approval of a drug candidate. • Phase 3: If the Phase 2 clinical trials demonstrate that a dose range of the drug candidate is potentially effective and has an acceptable safetyprofile, Phase 3 clinical trials are then undertaken in large patient populations to further evaluate dosage, to provide substantial evidence of clinicalefficacy and to further test for safety in an expanded and diverse patient population at multiple, geographically dispersed clinical trial sites. Phase 3trials are also intended to provide an adequate basis for extrapolating the results to the general population and transmitting that information in thedrug labeling. Phase 3 studies usually include several hundred to several thousand people, and are usually longer in duration than Phase 2 trials.At any time during the conduct of a clinical trial, the FDA or a foreign equivalent can impose a clinical hold on the trial if it believes the trial is unsafeor that the protocol is clearly deficient in design in meeting its stated objectives, which requires the conduct of the trial to cease until the clinical hold isremoved. In some cases, the FDA or foreign equivalent may condition approval of marketing approval for a drug candidate on the sponsor’s agreement toconduct additional clinical trials to further assess the drug’s safety and effectiveness after marketing approval, known as Phase 4 clinical trials.The clinical trials we conduct for our drug candidates, both before and after approval, and the results of those trials, are generally required to beincluded in a clinical trials registry database that is available and accessible to the public via the internet. A failure by us to properly participate in theclinical trial database registry could subject us to significant civil monetary penalties.Health care providers in the United States, including research institutions from which we or our partners obtain patient information, are subject toprivacy rules under the Health Insurance Portability and Accountability Act of 1996 and state and local privacy laws. In the European Union, these entitiesare subject to the Directive 95/46-EC of the European Parliament on the protection of individuals with regard to the processing of personal data andindividual European Union member states implementing additional legislation. Other countries have similar privacy legislation. We could face substantialpenalties if we knowingly receive individually identifiable health information from a health care provider that has not satisfied the applicable privacy laws.In addition, certain privacy laws and genetic testing laws may apply directly to our operations and/or those of our partners and may impose restrictions on theuse and dissemination of individuals’ health information and use of biological samples.New Drug/Marketing Approval Application. The results of drug candidate development, preclinical testing and clinical trials are submitted to theFDA as part of an NDA. The NDA also must contain extensive manufacturing information. In addition, the FDA may require that a proposed Risk Evaluationand Mitigation Strategy, also known as a REMS, be submitted as part of the NDA if the FDA determines that it is necessary to ensure that the benefits of thedrug outweigh its risks. Similar, and in some cases additional, requirements apply in foreign jurisdictions for marketing approval applications for drugs inthose jurisdictions. The FDA may refer the NDA to an advisory committee for review, evaluation and recommendation as to whether the application shouldbe approved. The FDA often, but not always, follows the advisory committee’s recommendations. The FDA may deny approval of an NDA by issuing acomplete response letter if the applicable regulatory criteria are not satisfied, or it may require additional clinical data, including data in a pediatricpopulation, or an additional Phase 3 clinical trial or impose other conditions that must be met in order to secure final approval for an NDA.Even if such data are submitted, the FDA may ultimately decide that the NDA does not satisfy the criteria for approval. Data from clinical trials are notalways conclusive and the FDA may interpret data differently than we or our partners do. Once issued, the FDA or foreign equivalent may withdraw a drugapproval if ongoing regulatory requirements are not met or if safety problems occur after the drug reaches the market. In addition, the FDA or its foreigncounterparts may require further testing, including Phase 4 clinical trials, and surveillance or restrictive distribution programs to monitor the effect ofapproved drugs which have been commercialized. The 23Table of ContentsFDA and its foreign counterparts have the power to prevent or limit further marketing of a drug based on the results of these post-marketing programs. Drugsmay be marketed only for the approved indications and in accordance with the provisions of the approved label. Further, if there are any modifications to adrug, including changes in indications, labeling or manufacturing processes or facilities, we may be required to submit and obtain prior FDA approval of anew NDA or NDA supplement, or the foreign equivalent, which may require us to develop additional data or conduct additional preclinical studies andclinical trials.Satisfaction of FDA regulations and requirements or similar requirements of state, local and foreign regulatory agencies typically takes several years.The actual time required may vary substantially based upon the type, complexity and novelty of the drug candidate or disease. Typically, if a drug candidateis intended to treat a chronic disease, as is the case with some of our drug candidates, safety and efficacy data must be gathered over an extended period oftime. Government regulation may delay or prevent marketing of drug candidates for a considerable period of time and impose costly procedures upon ouractivities. The FDA or any other regulatory agency may not grant approvals for new indications for our drug candidates on a timely basis, if at all. Even if adrug candidate receives regulatory approval, the approval may be significantly limited to specific disease states, patient populations and dosages orrestrictive distribution programs. Further, even after regulatory approval is obtained, later discovery of previously unknown problems with a drug may resultin restrictions on the drug or even complete withdrawal of the drug from the market. Delays in obtaining, or failures to obtain, regulatory approvals for any ofour drug candidates would harm our business. In addition, we cannot predict what future U.S. or foreign governmental regulations may be implemented.Orphan Drug Designation. Some jurisdictions, including the United States, may designate drugs for relatively small patient populations as orphandrugs. The FDA grants orphan drug designation to drugs intended to treat a rare disease or condition, which is generally a disease or condition that affectsfewer than 200,000 individuals in the United States. For example, the FDA has granted tirasemtiv an orphan drug designation for the treatment of ALS. Inaddition, the European Medicines Agency has granted tirasemtiv orphan medicinal product status for the treatment of ALS.An FDA orphan drug designation does not shorten the duration of the regulatory review and approval process. If a drug candidate that has an orphandrug designation receives the first FDA marketing approval for the indication for which the designation was granted, then the approved drug is entitled toorphan drug exclusivity. This means that the FDA may not approve another company’s application to market the same drug for the same indication for aperiod of seven years, except in certain circumstances, such as a showing of clinical superiority to the drug with orphan exclusivity or if the holder of theorphan drug designation cannot assure the availability of sufficient quantities of the orphan drug to meet the needs of patients with the disease or conditionfor which the designation was granted. Competitors may receive approval of different drugs or biologics for the indications for which the orphan drug hasexclusivity.Fast Track Designation. Fast track is a process designed by the FDA to facilitate the development and expedite the review of drugs to treat seriousdiseases and fill an unmet medical need. Tirasemtiv has been granted fast track designation by the FDA for the treatment of ALS. Although fast trackdesignation does not affect the standards for approval, the benefits of this designation include scheduled meetings to seek FDA input into developmentplans, the option of submitting an NDA in sections rather than all components simultaneously, and the potential eligibility for priority review if supported byclinical data.Other Regulatory Requirements. Any drugs manufactured or distributed by us or our partners pursuant to FDA approvals or their foreign counterpartsare subject to continuing regulation by the applicable regulatory authority, including recordkeeping requirements and reporting of adverse experiencesassociated with the drug. Drug manufacturers and their subcontractors are required to register their establishments with the FDA and other applicableregulatory authorities, and are subject to periodic unannounced inspections by these regulatory authorities for compliance with ongoing regulatoryrequirements, including cGMPs, which impose certain procedural and documentation requirements upon us and our third-party manufacturers. Failure tocomply with 24Table of Contentsthe statutory and regulatory requirements can subject a manufacturer to possible legal or regulatory action, such as warning letters, suspension ofmanufacturing, seizure of product, injunctive action or possible civil penalties. We cannot be certain that we or our present or future third-partymanufacturers or suppliers will be able to comply with the cGMP regulations and other ongoing FDA and other regulatory requirements. If our present orfuture third-party manufacturers or suppliers are not able to comply with these requirements, the FDA or its foreign counterparts may halt our or our partners’clinical trials, require us to recall a drug from distribution, or withdraw approval of the NDA for that drug.For further details on the risks relating to government regulation of our business, please see the risk factors under Item 1A of this report, including, butnot limited to, the risk factor entitled “The regulatory approval process is expensive, time-consuming and uncertain and may prevent our partners or us fromobtaining approvals to commercialize some or all of our drug candidates.”CompetitionWe compete in the segments of the pharmaceutical, biotechnology and other related markets that address neuromuscular and cardiovascular diseasesand other diseases relating to muscle dysfunction, each of which is highly competitive. We face significant competition from most pharmaceutical companiesand biotechnology companies that are also researching and selling products designed to address cardiovascular diseases and diseases and medical conditionsassociated with skeletal muscle weakness and wasting. Many of our competitors have significantly greater financial, manufacturing, marketing and drugdevelopment resources than we do. Large pharmaceutical companies in particular have extensive experience in clinical testing and in obtaining regulatoryapprovals for drugs. These companies also have significantly greater research capabilities than we do. In addition, many universities and private and publicresearch institutes are active in research of neuromuscular and cardiovascular diseases and other diseases where there is muscle dysfunction, some in directcompetition with us.We believe that our ability to successfully compete will depend on, among other things: • our drug candidates’ efficacy, safety and tolerability; • the speed and cost-effectiveness with which we develop our drug candidates; • the selection of suitable indications for which to develop our drug candidates; • the successful completion of clinical development and laboratory testing of our drug candidates; • the timing and scope of any regulatory approvals we or our partners obtain for our drug candidates; • our or our partners’ ability to manufacture and sell commercial quantities of our approved drugs to meet market demand; • acceptance of our drugs by physicians and other health care providers; • the willingness of third party payors to provide reimbursement for the use of our drugs; • our ability to protect our intellectual property and avoid infringing the intellectual property of others; • the quality and breadth of our technology; • our employees’ skills and our ability to recruit and retain skilled employees; • our cash flows under existing and potential future arrangements with licensees, partners and other parties; and • the availability of substantial capital resources to fund development and commercialization activities.Our competitors may develop drug candidates and market drugs that are less expensive and more effective than our future drugs or that may render ourdrugs obsolete. Our current or future competitors may also 25Table of Contentscommercialize competing drugs before we or our partners can launch any drugs developed from our drug candidates. These organizations also compete withus to attract qualified personnel and potential parties for acquisitions, joint ventures or other strategic alliances.If tirasemtiv is approved for marketing by the FDA or other regulatory authorities for the treatment of ALS, it may then compete with other potentialnew therapies for ALS that are currently being developed by companies such as Neuraltus Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc. (in collaborationwith Biogen), Genervon Biopharmaceuticals, LLC, Orion Pharmaceuticals, Orphazyme, Mitsubishi Tanabe Pharma Corporation, Eisai Co., Ltd., Genentech,Inc. Edison Pharma, Q Therapeutics, AB Science, VM Biopharm, Mallinckrodt Pharmaceuticals, Chronos Therapeutics, and MediciNova, Inc. In addition,BrainStorm Cell Therapeutics and Neuralstem, Inc. are each conducting clinical development of stem cell therapies for the potential treatment of ALS.Tirasemtiv may also compete with Riluteck (riluzole), manufactured by Sanofi, Marindale Pharma, and Italfarmaco and several generics manufacturersincluding Apotex Corp, Glenmark Generics, and Sun Pharmaceuticals.If CK-2127107 is approved by the FDA or other regulatory authorities for the potential treatment of SMA, potential competitors include Roche (incollaboration with PTC Therapeutics), AveXis, Inc., Pfizer Inc., Ionis Pharmaceuticals, Inc. (in collaboration with Biogen) which is being marketed asSpinraza, Novartis AG, and Bioblast Pharma, Ltd. Drugs that could compete with CK-2127107 could also compete against tirasemtiv in ALS or otherneuromuscular diseases, should the appropriate clinical trials be conducted. If CK-2127107 is approved by the FDA for the potential treatment ofnon-neuromuscular indications associated with muscle weakness, potential competitors include Ligand Pharmaceuticals, Inc., GTx, Inc., RegeneronPharmaceuticals, Inc. (in collaboration with Sanofi), Eli Lilly & Company, Acceleron Pharma, Stealth Biotherapeutics, Scholar Rock, vTv Therapeutics,Summit Therapeutics, Pfizer Inc., and Novartis (in collaboration with Morphosys AG).If omecamtiv mecarbil is approved for marketing by the FDA or other regulatory authorities for the treatment of heart failure, it would compete againstother drugs used for the treatment of chronic heart failure. These include generic drugs, such as milrinone, dobutamine or digoxin and branded drugs such asNatrecor (nesiritide), Corlanor (ivabradine), and Entresto (LCZ696). Omecamtiv mecarbil could also potentially compete against other novel drug candidatesand therapies in development, such as those being developed by ARCA biopharma, Inc., Novartis, Bayer, Capricor Therapeutics, Inc., Cardiorentis AG, OnoPharmaceutical Company, Juventas Therapeutics, ARMGO Pharma, Inc, Trevena, Inc. in partnership with Forest Laboratories, Inc. (acquired by Allergan, Plc),Stealth Biotherapeutics, Cardioxyl Pharmaceuticals, Inc., Zensun Sci & Tech, Ltd., and Tenax Therapeutics (formerly known as Oxygen Biotherapeutics,Inc.). In addition, there are a number of medical devices both marketed and in development for the potential treatment of heart failure.EmployeesAs of December 31, 2016, our workforce consisted of 127 full-time employees, 32 of whom hold Ph.D. or M.D. degrees, or both, and 32 of whom holdother advanced degrees. Of our total full-time employees, 86 are engaged in research and development and 41 are engaged in business and new productdevelopment, finance and administration functionsWe have no collective bargaining agreements with our employees, and we have not experienced any work stoppages. We believe that our relationswith our employees are good.Investor InformationWe file electronically with the SEC our annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K pursuant toSection 13 or 15(d) of the Exchange Act. The public may read or copy any materials we file with the SEC at the SEC’s Public Reference Room at 100 F Street,NE, Washington, DC 20549. The public may obtain information on the operation of the Public Reference Room by calling the SEC at 26Table of Contents1-800-SEC-0330. The SEC maintains an Internet site that contains reports, proxy and information statements, and other information regarding issuers that fileelectronically with the SEC. The address of that site is www.sec.gov.You may obtain a free copy of our annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K and amendments tothose reports on the day of filing with the SEC on our website at www.cytokinetics.com or by contacting the Investor Relations Department at our corporateoffices by calling 650-624-3060. The information found on our website is not part of this or any other report filed with or furnished to the SEC.Item 1A. Risk FactorsIn evaluating our business, you should carefully consider the following risks in addition to the other information in this report. Any of the followingrisks could materially and adversely affect our business, results of operations, financial condition or your investment in our securities, and many are beyondour control. The risks and uncertainties described below are not the only ones facing us. Additional risks and uncertainties not presently known to us, orthat we currently see as immaterial, may also adversely affect our business.Risks Related To Our BusinessWe have a history of significant losses and may not achieve or sustain profitability and, as a result, you may lose all or part of your investment.We have generally incurred operating losses in each year since our inception in 1997, due to costs incurred in connection with our research anddevelopment activities and general and administrative costs associated with our operations. Our drug candidates are all in early through late-stage clinicaltesting, and we and our partners must conduct significant additional clinical trials before we and our partners can seek the regulatory approvals necessary tobegin commercial sales of our drugs. We expect to incur increasing losses for at least several more years, as we continue our research activities and conductdevelopment of, and seek regulatory approvals for, our drug candidates, and commercialize any approved drugs. If our drug candidates fail or do not gainregulatory approval, or if our drugs do not achieve market acceptance, we will not be profitable. If we fail to become and remain profitable, or if we are unableto fund our continuing losses, you could lose all or part of your investment.We will need substantial additional capital in the future to sufficiently fund our operations.We have consumed substantial amounts of capital to date, and our operating expenditures will increase over the next several years if we expand ourresearch and development activities. We have funded all of our operations and capital expenditures with proceeds from private and public sales of our equitysecurities, strategic alliances with Amgen, Astellas and others, long term debt, equipment financings, interest on investments, government grants and othergrants. We believe that our existing cash and cash equivalents, short-term investments and interest earned on investments should be sufficient to meet ourprojected operating requirements for at least the next 12 months. We have based this estimate on assumptions that may prove to be wrong, and we couldutilize our available capital resources sooner than we currently expect. Because of the numerous risks and uncertainties associated with the development ofour drug candidates and other research and development activities, including risks and uncertainties that could impact the rate of progress of ourdevelopment activities, we are unable to estimate with certainty the amounts of capital outlays and operating expenditures associated with these activities.For the foreseeable future, our operations will require significant additional funding, in large part due to our research and development expenses andthe absence of any revenues from product sales. For example, we will require significant additional funding to enable us to conduct further development oftirasemtiv for the potential treatment of ALS, including any additional Phase 3 clinical trials that may be required by regulatory authorities 27Table of Contentsto receive marketing approval for tirasemtiv. Until we can generate a sufficient amount of product revenue, we expect to raise future capital through strategicalliance and licensing arrangements, public or private equity offerings and debt financings. We do not currently have any commitments for future fundingother than reimbursements, milestone and royalty payments that we may receive under our collaboration agreements with Amgen and Astellas. We may notreceive any further funds under those agreements. Our ability to raise funds may be adversely impacted by current economic conditions. As a result of theseand other factors, we do not know whether additional financing will be available when needed, or that, if available, such financing would be on termsfavorable to our stockholders or us.To the extent that we raise additional funds through strategic alliances or licensing and other arrangements with third parties, we will likely have torelinquish valuable rights to our technologies, research programs or drug candidates, or grant licenses on terms that may not be favorable to us. To the extentthat we raise additional funds by issuing equity securities, our stockholders will experience additional dilution and our share price may decline. To the extentthat we raise additional funds through debt financing, the financing may involve covenants that restrict our business activities. In addition, funding from anyof these sources, if needed, may not be available to us on favorable terms, or at all, or in accordance with our planned timelines.If we cannot raise the funds we need to operate our business, we will need to delay or discontinue certain research and development activities. Forexample, if we cannot raise the funds necessary to enable the conduct of further development for tirasemtiv for the potential treatment of ALS, our ability tocontinue the development of tirasemtiv will be delayed or suspended. If we delay or discontinue research and development activities, our stock price may benegatively affected.Covenants in our loan and security agreement restrict our business and operations in many ways and if we do not effectively manage our covenants, ourfinancial conditions and results of operations could be adversely affected. In addition, our operations may not provide sufficient revenue to meet thecondition required in order to access the final loan available under the agreement and may also not provide sufficient cash to meet the repaymentobligations of our debt incurred under the loan and security agreement.Our loan and security agreement with Oxford Finance LLC and Silicon Valley Bank provides for up to $40.0 million in term loans due on October 1,2020, of which $30.0 million in term loans has been borrowed to date. All of our current and future assets, except for intellectual property, are secured for ourborrowings under the loan and security agreement. The loan and security agreement requires that we comply with certain covenants applicable to us,including among other things, covenants restricting dispositions, changes in business, management, ownership or business locations, mergers or acquisitions,indebtedness, encumbrances, distributions, investments, transactions with affiliates and subordinated debt, any of which could restrict our business andoperations, particularly our ability to respond to changes in our business or to take specified actions to take advantage of certain business opportunities thatmay be presented to us. Our failure to comply with any of the covenants could result in a default under the loan and security agreement, which could permitthe lenders to declare all or part of any outstanding borrowings to be immediately due and payable, or to refuse to permit additional borrowings under theloan and security agreement. If we are unable to repay those amounts, the lenders under the loan and security agreement could proceed against the collateralgranted to them to secure that debt, which would seriously harm our business. In addition, should we be unable to comply with these covenants or if wedefault on any portion of our outstanding borrowings, the lenders can also impose a 5.0% penalty and restrict access to additional borrowings under the loanand security agreement. Moreover, our ability to access the final $10.0 million under the loan and security agreement is subject to our ability to achievecertain conditions, including certain clinical development milestones or an equity financing milestone, which conditions we may not be able to meet. Inaddition, although we expect to borrow additional funds under the loan and security agreement, before we do so, we must first satisfy ourselves that we willhave access to future alternate sources of capital, including cash flow from our own operations, equity capital markets or debt capital markets in order torepay any principal borrowed, which we may be unable to do, in which case, our liquidity and ability to fund our operations may be substantially impaired. 28Table of ContentsWe have never generated, and may never generate, revenues from commercial sales of our drugs and we will not have drugs to market for at leastseveral years, if ever.We currently have no drugs for sale and we cannot guarantee that we will ever develop or obtain approval to market any drugs. To receive marketingapproval for any drug candidate, we must demonstrate that the drug candidate satisfies rigorous standards of safety and efficacy to the FDA in the UnitedStates and other regulatory authorities abroad. We and our partners will need to conduct significant additional research and preclinical and clinical testingbefore we or our partners can file applications with the FDA or other regulatory authorities for approval of any of our drug candidates. In addition, to competeeffectively, our drugs must be easy to use, cost-effective and economical to manufacture on a commercial scale, compared to other therapies available for thetreatment of the same conditions. We may not achieve any of these objectives. Currently, our only drug candidates in clinical development are tirasemtiv forthe potential treatment of ALS, CK-2127107 for the potential treatment of SMA, COPD, ALS and potentially other neuromuscular and non-neuromuscularindications associated with muscle weakness and omecamtiv mecarbil for the potential treatment of heart failure. We cannot be certain that the clinicaldevelopment of these or any future drug candidates will be successful, that they will receive the regulatory approvals required to commercialize them, thatthey will ultimately be accepted by prescribers or reimbursed by insurers or that any of our other research programs will yield a drug candidate suitable forclinical testing or commercialization. Our commercial revenues, if any, will be derived from sales of drugs that we do not expect to be commercially marketedfor at least several years, if at all. The development of any one or all of these drug candidates may be discontinued at any stage of our clinical trials programsand we may not generate revenue from any of these drug candidates.Clinical trials may fail to demonstrate the desired safety and efficacy of our drug candidates, which could prevent or significantly delay completion ofclinical development and regulatory approval.Prior to receiving approval to commercialize any of our drug candidates, we or our partners must adequately demonstrate to the satisfaction of FDA andforeign regulatory authorities that the drug candidate is sufficiently safe and effective with substantial evidence from well-controlled clinical trials. We or ourpartners will need to demonstrate efficacy in clinical trials for the treatment of specific indications and monitor safety throughout the clinical developmentprocess and following approval. None of our drug candidates have yet met the safety and efficacy standards required for regulatory approval forcommercialization and they may never do so. In addition, for each of our preclinical compounds, we or our partners must adequately demonstrate satisfactorychemistry, formulation, stability and toxicity in order to submit an investigational new drug application (“IND”) to the FDA, or an equivalent application inforeign jurisdictions, that would allow us to advance that compound into clinical trials. Furthermore, we or our partners may need to submit separate INDs (orforeign equivalent) to different divisions within the FDA (or foreign regulatory authorities) in order to pursue clinical trials in different therapeutic areas.Each new IND (or foreign equivalent) must be reviewed by the new division before the clinical trial under its jurisdiction can proceed, entailing all the risksof delay inherent to regulatory review. If our or our partners’ current or future preclinical studies or clinical trials are unsuccessful, our business will besignificantly harmed and our stock price could be negatively affected.All of our drug candidates are prone to the risks of failure inherent in drug development. Preclinical studies may not yield results that wouldadequately support the filing of an IND (or a foreign equivalent) with respect to our potential drug candidates. Even if the results of preclinical studies for adrug candidate are sufficient to support such a filing, the results of preclinical studies do not necessarily predict the results of clinical trials. As an example,because the physiology of animal species used in preclinical studies may vary substantially from other animal species and from humans, it may be difficult toassess with certainty whether a finding from a study in a particular animal species will result in similar findings in other animal species or in humans. For anyof our drug candidates, the results from Phase 1 clinical trials in healthy volunteers and clinical results from Phase 1 and 2 trials in patients are not necessarilyindicative of the results of later and larger clinical trials that are necessary to establish whether the drug candidate is safe and effective for the applicableindication. Likewise, interim results from a clinical trial may not be indicative of the final results from that trial, and results from early Phase 2 29Table of Contentsclinical trials may not be indicative of the results from later clinical trials. For example, early Phase 2 clinical trials of tirasemtiv in patients with ALS showedencouraging dose-related trends in measurements of the ALS Functional Rating Scale in its revised form (ALSFRS-R), a clinically validated instrumentdesigned to measure disease progression and changes in functional status, for patients receiving tirasemtiv compared to those receiving placebo. However,BENEFIT-ALS, a Phase 2b clinical trial of tirasemtiv in patients with ALS, did not achieve its primary efficacy endpoint, the mean change from baseline inthe ALSFRS-R for patients receiving tirasemtiv compared to those receiving placebo.In addition, while the clinical trials of our drug candidates are designed based on the available relevant information, such information may notaccurately predict what actually occurs during the course of the trial itself, which may have consequences for the conduct of an ongoing clinical trial or forthe eventual results of that trial. For example, the number of patients planned to be enrolled in a placebo-controlled clinical trial is determined in part byestimates relating to expected treatment effect and variability about the primary endpoint. These estimates are based upon earlier nonclinical and clinicalstudies of the drug candidate itself and clinical trials of other drugs thought to have similar effects in a similar patient population. If information gainedduring the conduct of the trial shows these estimates to be inaccurate, we may elect to adjust the enrollment accordingly, which may cause delays incompleting the trial, additional expense or a statistical penalty to apply to the evaluation of the trial results.Furthermore, in view of the uncertainties inherent in drug development, such clinical trials may not be designed with focus on indications, patientpopulations, dosing regimens, endpoints, safety, efficacy or pharmacokinetic parameters or other variables that will provide the necessary safety or efficacydata to support regulatory approval to commercialize the resulting drugs. For example, we believe that effects on respiratory function, including slow vitalcapacity (SVC), may be appropriate as a clinical endpoint for tirasemtiv; however, regulatory authorities may not accept these effects as a clinical endpoint tosupport registration of tirasemtiv for the treatment of ALS. Clinical trials of our drug candidates are designed based on guidance or advice from regulatoryagencies, which is subject to change during the development of the drug candidate at any time. Such a change in a regulatory agency’s guidance or advicemay cause that agency to deem results from trials to be insufficient to support approval of the drug candidate and require further clinical trials of that drugcandidate to be conducted. In addition, individual patient responses to the dose administered of a drug may vary in a manner that is difficult to predict. Also,the methods we select to assess particular safety, efficacy or pharmacokinetic parameters may not yield the same statistical precision in estimating our drugcandidates’ effects as may other methodologies. Even if we believe the data collected from clinical trials of our drug candidates are promising, these data maynot be sufficient to support approval by the FDA or foreign regulatory authorities. Non-clinical and clinical data can be interpreted in different ways.Accordingly, the FDA or foreign regulatory authorities could interpret these data in different ways from us or our partners, which could delay, limit or preventregulatory approval.Administering any of our drug candidates or potential drug candidates may produce undesirable side effects, also known as adverse events. Toxicitiesand adverse events observed in preclinical studies for some compounds in a particular research and development program may also occur in preclinicalstudies or clinical trials of other compounds from the same program. Potential toxicity issues may arise from the effects of the active pharmaceuticalingredient itself or from impurities or degradants that are present in the active pharmaceutical ingredient or could form over time in the formulated drugcandidate or the active pharmaceutical ingredient. These toxicities or adverse events could delay or prevent the filing of an IND (or a foreign equivalent) withrespect to our drug candidates or potential drug candidates or cause us, our partners or the FDA or foreign regulatory authorities to modify, suspend orterminate clinical trials with respect to any drug candidate at any time during the development program. Further, the administration of two or more drugscontemporaneously can lead to interactions between them, and our drug candidates may interact with other drugs that trial subjects are taking. For example,co-administration of tirasemtiv and riluzole (an approved treatment for ALS) approximately doubles the average maximum riluzole plasma level. If theadverse events are severe or frequent enough to outweigh the potential efficacy of a drug candidate, the FDA or other regulatory authorities could denyapproval 30Table of Contentsof that drug candidate for any or all targeted indications. Even if one or more of our drug candidates were approved for sale as drugs, the occurrence of even alimited number of toxicities or adverse events when used in large populations may cause the FDA or foreign regulatory authorities to impose restrictions on,or stop, the further marketing of those drugs. Indications of potential adverse events or toxicities which do not seem significant during the course of clinicaltrials may later turn out to actually constitute serious adverse events or toxicities when a drug is used in large populations or for extended periods of time.We have observed certain adverse events in the clinical trials conducted with our drug candidates. For example, in BENEFIT-ALS, adverse events ofdizziness, fatigue, nausea, confusional state, muscle spasms, somnolence (sleepiness), decreased appetite, headache, insomnia, dyspnea (difficulty breathing)and dysathria (difficulty speaking) occurred more frequently during treatment with tirasemtiv than with placebo. In addition, weight loss was significantlygreater in patients with gastrointestinal adverse events (e.g., nausea and decreased appetite), which occurred more frequently on tirasemtiv than on placebo.In clinical trials of omecamtiv mecarbil, adverse events of chest discomfort, palpitations, dizziness and feeling hot, increases in heart rate, declines in bloodpressure, electrocardiographic changes consistent with acute myocardial ischemia and transient rises in the MB fraction of creatine kinase and cardiactroponins I and T, which are indicative of myocardial infarction were observed during treatment with omecamtiv mecarbil.In addition, clinical trials of tirasemtiv and omecamtiv mecarbil enroll patients who typically suffer from serious diseases which put them at increasedrisk of death. These patients may die while receiving our drug candidates. In such circumstances, it may not be possible to exclude with certainty a causalrelationship to our drug candidate, even though the responsible clinical investigator may view such an event as not study drug-related.Any failure or significant delay in completing preclinical studies or clinical trials for our drug candidates, or in receiving and maintaining regulatoryapproval for the sale of any resulting drugs, may significantly harm our business and negatively affect our stock price.The failure of a number of Phase 3 clinical trials evaluating other compounds as potential treatments for patients with ALS may suggest an increasedrisk that our planned Phase 3 clinical development program of tirasemtiv in patients with ALS will also fail.The FDA has not approved any drug for the treatment of ALS since its approval of riluzole in 1995. In recent years, a number of Phase 3 clinical trialsof potential treatments for ALS have failed to demonstrate the requisite efficacy for approval or for their continued development. These include Biogen’s trialof dexpramipexole, known as EMPOWER, the National Institute of Neurological Disorders and Stroke’s trial of ceftriaxone, and Trophos SA’s trial ofolesoxime. Tirasemtiv, like these compounds, may fail in Phase 3 clinical development if it does not show a statistically significant level of clinical efficacyor if the adverse event profile is too great compared to it benefits. Further, even if we believe the data collected from our planned Phase 3 clinicaldevelopment program of tirasemtiv are promising and should support approval, the FDA or other regulatory authorities may not deem these data to besufficient to support approval.We have never before conducted a Phase 3 clinical trial nor submitted an application for marketing authorization to regulatory authorities, and may beunable to do so for tirasemtiv or any other drug candidates we are developing.We are conducting VITALITY-ALS, a Phase 3 clinical trial, designed to assess the effects of tirasemtiv versus placebo on slow vital capacity (“SVC”)and other measure of respiratory function in patients with ALS. Conducting Phase 3 clinical trials and submitting a successful application for marketingauthorization is complex, time consuming and expensive. We have not previously conducted a Phase 3 clinical trial and have limited experience inpreparing, submitting and prosecuting a marketing authorization. Consequently, we may be unable to effectively and efficiently execute and complete thetrial in a manner that leads to the submission to 31Table of Contentsand approval by regulatory authorities of a marketing application for tirasemtiv. We may require more time and incur greater costs than our competitors andmay not succeed in obtaining regulatory approvals of products that we develop. Failure to commence or complete, or delays in, our planned clinical trials,would prevent us from or delay us in commercializing tirasemtiv, and other product candidates we are developing.Neither the FDA nor European regulatory authorities has accepted the primary endpoint in our Phase 3 clinical trial in patients with ALS (astatistically significant reduction in the decline in SVC) as a sufficient measure of clinical significance alone to support regulatory approval oftirasemtiv for the treatment of ALS.To commercialize tirasemtiv, we must first demonstrate to the satisfaction of the FDA or foreign regulatory authorities that tirasemtiv is sufficiently safeand effective. To date, neither the FDA nor European regulatory authorities has indicated that the primary endpoint that we have specified in our Phase 3clinical trial in patients with ALS (change from baseline to 24 weeks in SVC) is, in and of itself, a sufficient measure of clinical significance to establish theefficacy of tirasemtiv. Our Phase 3 clinical trial will also be measuring secondary endpoints of respiratory function and patient condition to provide furtherevidence of the potential clinical significance of a treatment effect. However, there is no assurance as to which of these secondary endpoints (if any) will beaffected even if treatment with tirasemtiv achieves the primary efficacy objective of the trial. Further, there is no assurance as to whether regulatoryauthorities would accept the outcome of the trial as being a sufficient demonstration of clinical efficacy even if the primary endpoint and all secondaryendpoints are achieved. We will continue interactions with regulatory authorities regarding the appropriate assessment(s) of the clinical meaningfulness andpotential efficacy of therapy in the ALS population. If the results of our Phase 3 clinical trial in ALS are not sufficient to persuade regulatory authorities ofthe safety and efficacy of tirasemtiv, either because of a failure to achieve pre-specified endpoints or because the authorities do not accept such endpoints asbeing sufficient, then we would be required to conduct successfully one or more additional Phase 3 clinical trials, prior to receiving marketing authorization,which would be expensive, time consuming and uncertain.It is not known whether the FDA or other regulatory authorities would accept a single Phase 3 clinical trial as being adequate to support marketingapproval of tirasemtiv, even if the results of such trial are positive.The conventional standard for granting marketing authorization of a new investigational medicine is the demonstration of safety and efficacy in twolarge, well-controlled Phase 3 clinical trials. The Phase 3 trial of tirasemtiv in ALS that we are currently conducting will be the first Phase 3 trial of this drugcandidate. In the case of diseases with high unmet medical need, such as ALS, regulatory authorities may exercise their discretion to approve a newpharmaceutical on the basis of a single outcomes trial (sometimes subject to the conduct of subsequent confirmatory trial(s)). However, this is always withinthe judgment of the regulatory authorities and is dependent on their assessment of the degree of success achieved in the clinical trial as balanced by thepotential risks associated with treatment. In addition, the design of the Phase 3 clinical trial, VITALITY-ALS, may not provide conclusive data on the mostsafe and effective dose of tirasemtiv in patients with ALS that meets the satisfaction of regulatory authorities, thereby requiring us to conduct another Phase 3trial. Even if our first Phase 3 trial of tirasemtiv shows positive results, and provides all necessary data to determine appropriate dosing, regulatory authoritiesmay nonetheless require us to successfully conduct one or more additional Phase 3 clinical trials prior to receiving marketing authorization, which would beexpensive, time consuming and uncertain.Clinical trials are expensive, time-consuming and subject to delay.Clinical trials are subject to rigorous regulatory requirements and are very expensive, difficult and time-consuming to design and implement. Thelength of time and number of trial sites and patients required for clinical trials vary substantially based on the type, complexity, novelty, intended use of thedrug candidate and safety concerns. We estimate that the clinical trials of our current drug candidates will each continue for several more years. However, theclinical trials for all or any of our drug candidates may take significantly longer to 32Table of Contentscomplete. The commencement and completion of our or our partners’ clinical trials could be delayed or prevented by many factors, including, but not limitedto: • delays in obtaining, or inability to obtain, regulatory or other approvals to commence and conduct clinical trials in the manner we or our partnersdeem necessary for the appropriate and timely development of our drug candidates and commercialization of any resulting drugs; • delays in identifying and reaching agreement, or inability to identify and reach agreement, on acceptable terms, with prospective clinical trial sitesand other entities involved in the conduct of our or our partners’ clinical trials; • delays or additional costs in developing, or inability to develop, appropriate formulations of our drug candidates for clinical trial use, including anappropriate modified release oral formulation for omecamtiv mecarbil; • slower than expected rates of patient recruitment and enrollment, including as a result of competition for patients with other clinical trials; limitednumbers of patients that meet the enrollment criteria; patients’, investigators’ or trial sites’ reluctance to agree to the requirements of a protocol; orthe introduction of alternative therapies or drugs by others; • for those drug candidates that are the subject of a strategic alliance, delays in reaching agreement with our partner as to appropriate developmentstrategies; • a regulatory authority may require changes to a protocol for a clinical trial that then may require approval from regulatory agencies in otherjurisdictions where the trial is being conducted; • an institutional review board (“IRB”) or its foreign equivalent may require changes to a protocol that then require approval from regulatory agenciesand other IRBs and their foreign equivalents, or regulatory authorities may require changes to a protocol that then require approval from the IRBs ortheir foreign equivalents; • for clinical trials conducted in foreign countries, the time and resources required to identify, interpret and comply with foreign regulatoryrequirements or changes in those requirements, and political instability or natural disasters occurring in those countries; • lack of effectiveness of our drug candidates during clinical trials; • unforeseen safety issues; • inadequate supply, or delays in the manufacture or supply, of clinical trial materials; • uncertain dosing issues; • failure by us, our partners, or clinical research organizations, investigators or site personnel engaged by us or our partners to comply with goodclinical practices and other applicable laws and regulations, including those concerning informed consent; • inability or unwillingness of investigators or their staffs to follow clinical protocols; • failure by our clinical research organizations, clinical manufacturing organizations and other third parties supporting our or our partners’ clinicaltrials to fulfill their obligations; • inability to monitor patients adequately during or after treatment; • introduction of new therapies or changes in standards of practice or regulatory guidance that render our drug candidates or their clinical trialendpoints obsolete; and • results from non-clinical studies that may adversely impact the timing or further development of our drug candidates.We do not know whether planned clinical trials will begin on time, or whether planned or currently ongoing clinical trials will need to be restructuredor will be completed on schedule, if at all. Significant delays in clinical 33Table of Contentstrials will impede our ability to commercialize our drug candidates and generate revenue and could significantly increase our development costs.We depend on Amgen for the conduct and funding of the development and commercialization of omecamtiv mecarbil.Under our strategic alliance, Amgen holds an exclusive worldwide license to our drug candidate omecamtiv mecarbil. As a result, Amgen is responsiblefor the development and obtaining and maintaining regulatory approval of omecamtiv mecarbil for the potential treatment of heart failure worldwide.While we announced in September 2016 that Amgen was advancing omecamtiv mecarbil into Phase 3 clinical development, we do not control thedevelopment activities being conducted or that may be conducted in the future by Amgen, including, but not limited to, the timing of initiation, terminationor completion of clinical trials, the analysis of data arising out of those clinical trials or the timing of release of data concerning those clinical trials, whichmay impact our ability to report on Amgen’s results. Amgen may conduct these activities more slowly or in a different manner than we would if we controlledthe development of omecamtiv mecarbil. Amgen is responsible for filing future applications with the FDA and other regulatory authorities for approval ofomecamtiv mecarbil and will be the owner of marketing approvals issued by the FDA or other regulatory authorities for omecamtiv mecarbil, subject toServier’s exclusive rights for the commercialization of omecamtiv mecarbil in Europe, as well as the CIS, including Russia. If the FDA or other regulatoryauthorities approve omecamtiv mecarbil, Amgen will also be responsible for the marketing and sale of the resulting drug, subject to our right to co-promoteomecamtiv mecarbil in North America if we exercise our option to co-fund Phase 3 development costs of omecamtiv mecarbil under the collaboration andsubject to Servier’s exclusive rights for the commercialization of omecamtiv mecarbil in Europe, as well as the CIS, including Russia. However, we cannotcontrol whether Amgen will devote sufficient attention and resources to the development of omecamtiv mecarbil or will proceed in an expeditious manner,even if we do exercise our option to co-fund the development of omecamtiv mecarbil. Even if the FDA or other regulatory agencies approve omecamtivmecarbil, Amgen or Servier may elect not to proceed with the commercialization of the resulting drug in one or more countries.If the results of one or more clinical trials with omecamtiv mecarbil do not meet Amgen’s expectations at any time, Amgen may elect to terminatefurther development of omecamtiv mecarbil or certain of the potential clinical trials for omecamtiv mecarbil, even if the actual number of patients treated atthat time is relatively small. In addition, Amgen generally has discretion to elect whether to pursue or abandon the development of omecamtiv mecarbil andmay terminate our strategic alliance for any reason upon six months prior notice. With our consent, Amgen granted Servier an option to commercializeomecamtiv mecarbil in Europe and the CIS, including Russia, which Servier decided to exercise. In August 2016, we entered into a letter agreement withAmgen and Servier, which provides that if Amgen’s rights to omecamtiv mecarbil are terminated with respect to the territory subject to Servier’s sublicense,the sublicensed rights previously granted by Amgen to Servier with respect to omecamtiv mecarbil, will remain in effect and become a direct license orsublicense of such rights by us to Servier, on substantially the same terms as those in the Option, License and Collaboration Agreement between Amgen andServier. If Amgen abandons omecamtiv mecarbil, it would result in a delay in or could prevent us from commercializing omecamtiv mecarbil, and woulddelay and could prevent us from obtaining revenues for this drug candidate. In addition, we would be required to provide Servier with a direct license orsublicense and the rights to commercialize omecamtiv mecarbil in Europe and the CIS, including Russia on terms that were not negotiated by us. There canbe no assurance that we would be able to negotiate and enter into a definitive agreement with Servier on terms favorable or acceptable to us, or at all.Disputes may arise between us and Amgen, which may delay or cause the termination of any omecamtiv mecarbil clinical trials, result in significantlitigation or cause Amgen to act in a manner that is not in our best interest. The costs associated with the continuing development of omecamtiv mecarbilmay cause Amgen to reconsider the terms of its investment and seek to amend or terminate our collaboration agreement or to suspend the development ofomecamtiv mecarbil. If development of omecamtiv mecarbil does not progress for these or 34Table of Contentsany other reasons, we would not receive further milestone payments or royalties on product sales from Amgen with respect to omecamtiv mecarbil. If Amgenabandons development of omecamtiv mecarbil prior to regulatory approval or if it elects not to proceed with commercialization of the resulting drugfollowing regulatory approval, we would have to seek a new partner for development or commercialization, curtail or abandon that development orcommercialization, or undertake and fund the development of omecamtiv mecarbil or commercialization of the resulting drug ourselves. If we seek a newpartner but are unable to do so on acceptable terms, or at all, or do not have sufficient funds to conduct the development or commercialization of omecamtivmecarbil ourselves, we would have to curtail or abandon that development or commercialization, which could harm our business.We depend on Astellas for the conduct and funding of the development and commercialization of CK-2127107.In December 2014, we expanded our strategic alliance with Astellas focused on the research, development and commercialization of skeletal muscleactivators, other than tirasemtiv and certain related compounds. The primary objective of the strategic alliance is to advance novel therapies for indicationsassociated with muscle weakness.Under this strategic alliance, we have granted Astellas an exclusive license to co-develop and commercialize CK-2127107 for potential application inspinal muscular atrophy (SMA) and potentially other indications worldwide. We have initiated a Phase 2 clinical trial of patients with SMA and in June2016, Astellas, in collaboration with us, initiated a Phase 2 clinical trial of CK-2127107 in patients with COPD.In September 2016, we expanded our collaboration with Astellas and granted Astellas an option to enter into a pre-negotiated agreement for a globalcollaboration for the development and commercialization of tirasemtiv, including worldwide commercialization rights for Astellas outside ourcommercialization territory in North America, Europe and other select countries. In addition, under this 2016 expansion, we will collaborate with Astellas todevelop CK-2127107 in ALS. Astellas will be primarily responsible for the development of CK-2127107 in ALS, and the Company will conduct the Phase 2clinical trial of CK-2127107 in ALS.We do not control the development activities that may be conducted by Astellas, including, but not limited to, the timing of initiation, termination orcompletion of clinical trials, the analysis of data arising out of those clinical trials or the timing of release of data concerning those clinical trials, which mayimpact our ability to report on Astellas’ results. Astellas may conduct these activities more slowly or in a different manner than we would. In general, Astellasis responsible for filing future applications with the FDA or other regulatory authorities for approval of CK-2127107 and will be the owner of any marketingapprovals issued by the FDA or other regulatory authorities for CK-2127107. If the FDA or other regulatory authorities approve CK-2127107, Astellas willalso be responsible for the marketing and sale of the resulting drug, subject to our right to co-promote the drug in the United States, Canada and, forneuromuscular indications, Europe. However, we cannot control whether Astellas will devote sufficient attention and resources to the development ofCK-2127107 or will proceed in an expeditious manner. Even if the FDA or other regulatory agencies approve CK-2127107, Astellas may elect not to proceedwith the commercialization of the resulting drug in one or more countries.If the results of one or more clinical trials with CK-2127107 do not meet Astellas’ expectations at any time, Astellas may elect to terminate furtherdevelopment of CK-2127107 or certain of the potential clinical trials for CK-2127107, even if the actual number of patients treated at that time is relativelysmall. In addition, Astellas generally has discretion to elect whether to pursue or abandon the development of CK-2127107. Astellas may terminate ourstrategic alliance in whole or in part for any reason upon six months prior notice at any time following expiration of the strategic alliance’s research term,which will expire December 31, 2017. If Astellas abandons CK-2127107, it would result in a delay in or could prevent us from further developing orcommercializing CK-2127107, and would delay and could prevent us from obtaining revenues for this drug candidate. Disputes may arise between us andAstellas, which may delay or cause the termination of any CK-2127107 clinical trials, result in significant litigation or cause Astellas to act in a manner thatis not in our 35Table of Contentsbest interest. If development of CK-2127107 does not progress for these or any other reasons, we would not receive further milestone payments or royalties onproduct sales from Astellas with respect to CK-2127107. If Astellas abandons development of CK-2127107 prior to regulatory approval or if it elects not toproceed with commercialization of the resulting drug following regulatory approval, we would have to seek a new partner for development orcommercialization, curtail or abandon that development or commercialization, or undertake and fund the development of CK-2127107 or commercializationof the resulting drug ourselves. If we seek a new partner but are unable to do so on acceptable terms, or at all, or do not have sufficient funds to conduct thedevelopment or commercialization of CK-2127107 ourselves, we would have to curtail or abandon that development or commercialization, which couldharm our business.The successful development of CK-2127107 in ALS under our expanded collaboration with Astellas could reduce the commercial potential oftirasemtiv, and our share of the costs of developing CK-2127107 in ALS could limit our ability to pay for other programs, including tirasemtiv.Tirasemtiv is the lead drug candidate from our skeletal muscle contractility program. We have completed a Phase 2 clinical development program fortirasemtiv, and started a Phase 3 clinical development program for tirasemtiv in patients with ALS in July 2015. In collaboration with Astellas, we are alsodeveloping CK-2127107 for potential indications associated with muscle weakness and in 2016 we expanded our collaboration with Astellas to developCK-2127107 in ALS. We expect that we will commence a Phase 2 clinical development program of CK-2127107 with Astellas in ALS in 2017.Since we will be developing both tirasemtiv and CK-2127107 for ALS, if both drugs are successfully developed and commercialized, they wouldpotentially compete with one another in the same indication. If approved for commercial sale, the commercial launch of CK-2127107 following thecommercial launch of tirasemtiv could negatively affect the sales of tirasemtiv. Successful development of CK-2127107 in ALS, or CK-2127107 data thatAstellas views as positive, may reduce the likelihood that Astellas will exercise its option to develop and commercialize tirasemtiv, in which case we wouldnot receive any of the payments from Astellas associated with the option exercise, and our ability to commercially launch tirasemtiv in markets outside ofNorth America and Europe may be diminished.In addition, Astellas and Cytokinetics will share equally the costs of developing CK-2127107 in ALS for potential registration and marketingauthorization in the U.S. and Europe, provided that (i) Astellas has agreed to solely fund Phase 2 development costs of CK-2127107 in ALS subject to a rightto recoup our share of such costs plus a 100% premium by reducing future milestone and royalty payments to the Company and (ii) we may defer (but noteliminate) a portion of our co-funding obligation for development activities after Phase 2 for up to 18 months, subject to certain conditions. We will,however, be required to fund one half the cost of any Phase 3 development of CK-2127107 in ALS with limited ability to defer or offset such costs. Ourone-half share of the costs of any Phase 3 clinical trial of CK-2127107 in ALS could be significant, and could negatively impact our ability to finance otherprograms, including potentially limiting our ability to pay for the development and/or commercial launch of tirasemtiv.If we do not enter into strategic alliances for our unpartnered drug candidates or research and development programs or fail to successfully maintainour current or future strategic alliances, we may have to reduce, delay or discontinue our advancement of our drug candidates and programs or expandour research and development capabilities and increase our expenditures.Drug development is complicated and expensive. We currently have limited financial and operational resources to carry out drug development. Ourstrategy for developing, manufacturing and commercializing our drug candidates currently requires us to enter into and successfully maintain strategicalliances with pharmaceutical companies or other industry participants to advance our programs and reduce our expenditures on each program. Accordingly,the success of our development activities depends in large part on our current and future strategic partners’ performance, over which we have little or nocontrol. 36Table of ContentsOur ability to commercialize drugs that we develop with our partners and that generate royalties from product sales depends on our partners’ abilities toassist us in establishing the safety and efficacy of our drug candidates, obtaining and maintaining regulatory approvals and achieving market acceptance ofthe drugs once commercialized. Our partners may elect to delay or terminate development of one or more drug candidates, independently develop drugs thatcould compete with ours or fail to commit sufficient resources to the marketing and distribution of drugs developed through their strategic alliances with us.Our partners may not proceed with the development and commercialization of our drug candidates with the same degree of urgency as we would because ofother priorities they face. In addition, new business combinations or changes in a partner’s business strategy may adversely affect its willingness or ability tocarry out its obligations under a strategic alliance.If we are not able to successfully maintain our existing strategic alliances or establish and successfully maintain additional strategic alliances, we willhave to limit the size or scope of, or delay or discontinue, one or more of our drug development programs or research programs, or undertake and fund theseprograms ourselves. Alternatively, if we elect to continue to conduct any of these drug development programs or research programs on our own, we will needto expand our capability to conduct clinical development by bringing additional skills, technical expertise and resources into our organization. This wouldrequire significant additional funding, which may not be available to us on acceptable terms, or at all.To the extent we elect to fund the development of a drug candidate, such as tirasemtiv, CK-2127107, or omecamtiv mecarbil, or the commercializationof a drug at our expense, we will need substantial additional funding.The discovery, development and commercialization of new drugs is costly. As a result, to the extent we elect to fund the development of a drugcandidate, such as tirasemtiv, CK-2127107 or omecamtiv mecarbil, or the commercialization of a drug, we will need to raise additional capital to: • fund clinical trials and seek regulatory approvals; • expand our development capabilities; • engage third party manufacturers for such drug candidate or drug; • build or access commercialization capabilities; • implement additional internal systems and infrastructure; • maintain, defend and expand the scope of our intellectual property; and • hire and support additional management and scientific personnel.Our future funding requirements will depend on many factors, including, but not limited to: • the rate of progress and costs of our or our partners’ clinical trials and other research and development activities; • the costs and timing of seeking and obtaining regulatory approvals; • the costs associated with establishing manufacturing and commercialization capabilities; • the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights; • the costs of acquiring or investing in businesses, products and technologies; • the effect of competing technological and market developments; and • the status of, payment and other terms, and timing of any strategic alliance, licensing or other arrangements that we have entered into or mayestablish. 37Table of ContentsUntil we can generate a sufficient amount of product revenue to finance our cash requirements, which we may never do, we expect to continue tofinance our future cash needs primarily through strategic alliances, public or private equity offerings and debt financings. We cannot be certain thatadditional funding will be available on acceptable terms, or at all. If we are not able to secure additional funding when needed, we may have to delay, reducethe scope of or eliminate one or more of our clinical trials or research and development programs or future commercialization initiatives.We depend on contract research organizations (“CROs”) to conduct our clinical trials and have limited control over their performance. If these CROsdo not successfully carry out their contractual duties or meet expected deadlines, or if we lose any of our CROs, we may not be able to obtain regulatoryapproval for or commercialize our product candidates on a timely basis, if at all.We have used and intend to continue to use a limited number of CROs within and outside of the United States to conduct clinical trials of our drugcandidates, such as tirasemtiv, CK-2127107 and omecamtiv mecarbil, and related activities. We do not have control over many aspects of our CROs’activities, and cannot fully control the amount, timing or quality of resources that they devote to our programs. CROs may not assign as high a priority to ourprograms or pursue them as diligently as we would if we were undertaking these programs ourselves. The activities conducted by our CROs therefore may notbe completed on schedule or in a satisfactory manner. CROs may also give higher priority to relationships with our competitors and potential competitorsthan to their relationships with us. Outside of the United States, we are particularly dependent on our CROs’ expertise in communicating with clinical trialsites and regulatory authorities and ensuring that our clinical trials and related activities and regulatory filings comply with applicable laws.Our CROs’ failure to carry out development activities on our behalf as agreed and in accordance with our and the FDA’s or other regulatory agencies’requirements and applicable U.S. and foreign laws, or our failure to properly coordinate and manage these activities, could increase the cost of our operationsand delay or prevent the development, approval and commercialization of our drug candidates. For example, in June 2013, we learned from our datamanagement vendor for BENEFIT-ALS that a programming error in the electronic data capture system controlling study drug assignment caused 58 patientsinitially randomized to and treated with tirasemtiv to receive placebo instead at a certain trial visit and for the remainder of the trial. In order to maintain theoriginally intended statistical power of the trial, we amended the protocol to permit enrollment of approximately 680 patients, or 180 patients in addition tothe 500 patients allowed under the existing protocol. This protocol amendment resulted in additional costs and delays in conducting BENEFIT-ALS. Further,for the quarter ended September 30, 2016, we determined that there was an error in the accounting for the recognition of clinical research and developmentexpenses related to the information received from one of our CROs, which resulted in a restatement of our clinical research and development expenses,related clinical accrual accounts and related financial disclosures as of and for the three and nine month periods ended September 30, 2016. In addition, if aCRO fails to perform as agreed, our ability to collect damages may be contractually limited. If we fail to effectively manage the CROs carrying out thedevelopment of our drug candidates or if our CROs fail to perform as agreed, the commercialization of our drug candidates will be delayed or prevented. Inmany cases, our CROs have the right to terminate their agreements with us in the event of an uncured material breach. Identifying, qualifying and managingperformance of third-party service providers can be difficult, time consuming and cause delays in our development programs. In addition, there is a naturaltransition period when a new CRO commences work and the new CRO may not provide the same type or level of services as the original provider. If any ofour relationships with our third-party CROs terminate, we may not be able to enter into arrangements with alternative CROs or to do so timely or oncommercially reasonable terms. 38Table of ContentsWe have no manufacturing capacity and depend on our strategic partners and contract manufacturers to produce our clinical trial materials, includingour drug candidates, and anticipate continued reliance on contract manufacturers for the development and commercialization of our potential drugs.We do not currently operate manufacturing facilities for clinical or commercial production of our drug candidates. We have limited experience in drugformulation and manufacturing, and we lack the resources and the capabilities to manufacture any of our drug candidates on a clinical or commercial scale.Amgen has assumed responsibility to conduct these activities for the ongoing development of omecamtiv mecarbil worldwide. Following our conduct of theearly development of CK-2127107, including the ongoing Phase 2 clinical trial in patients with SMA, Astellas will assume primary responsibility to conductthe manufacturing for the ongoing development of CK-2127107 worldwide. For tirasemtiv, we rely on a limited number of contract manufacturers. Inparticular, we rely on single-source contract manufacturers for the active pharmaceutical ingredient and the drug product supply for our clinical trials, as wellas other materials required to conduct our clinical trials. We expect to rely on contract manufacturers to supply all future drug candidates for which weconduct development, as well as other materials required to conduct our clinical trials. If any of our existing or future contract manufacturers fail to performsatisfactorily, it could delay development or regulatory approval of our drug candidates or commercialization of our drugs, producing additional losses anddepriving us of potential product revenues. In addition, if a contract manufacturer fails to perform as agreed, our ability to collect damages may becontractually limited.Our drug candidates require precise high-quality manufacturing. The failure to achieve and maintain high manufacturing standards, including failureto detect or control anticipated or unanticipated manufacturing errors or the frequent occurrence of such errors, could result in patient injury or death,discontinuance or delay of ongoing or planned clinical trials, delays or failures in product testing or delivery, cost overruns, product recalls or withdrawalsand other problems that could seriously hurt our business. Contract drug manufacturers often encounter difficulties involving production yields, qualitycontrol and quality assurance and shortages of qualified personnel. These manufacturers are subject to stringent regulatory requirements, including the FDA’scurrent good manufacturing practices regulations and similar foreign laws and standards. Each contract manufacturer must pass a pre-approval inspectionbefore we can obtain marketing approval for any of our drug candidates and following approval will be subject to ongoing periodic unannouncedinspections by the FDA, the U.S. Drug Enforcement Agency and other regulatory agencies, to ensure strict compliance with current good manufacturingpractices and other applicable government regulations and corresponding foreign laws and standards. We seek to ensure that our contract manufacturerscomply fully with all applicable regulations, laws and standards. However, we do not have control over our contract manufacturers’ compliance with theseregulations, laws and standards. If one of our contract manufacturers fails to pass its pre-approval inspection or maintain ongoing compliance at any time, theproduction of our drug candidates could be interrupted, resulting in delays or discontinuance of our clinical trials, additional costs and potentially lostrevenues. In addition, failure of any third party manufacturers or us to comply with applicable regulations, including pre- or post-approval inspections andthe current good manufacturing practice requirements of the FDA or other comparable regulatory agencies, could result in sanctions being imposed on us.These sanctions could include fines, injunctions, civil penalties, failure of regulatory authorities to grant marketing approval of our products, delay,suspension or withdrawal of approvals, license revocation, product seizures or recalls, operational restrictions and criminal prosecutions, any of which couldsignificantly and adversely affect our business.In addition, our existing and future contract manufacturers may not perform as agreed or may not remain in the contract manufacturing business for thetime required to successfully produce, store and distribute our drug candidates. If a natural disaster, business failure, strike or other difficulty occurs, we maybe unable to replace these contract manufacturers in a timely or cost-effective manner and the production of our drug candidates would be interrupted,resulting in delays and additional costs.Switching manufacturers or manufacturing sites would be difficult and time-consuming because the number of potential manufacturers is limited. Inaddition, before a drug from any replacement manufacturer or 39Table of Contentsmanufacturing site can be commercialized, the FDA and, in some cases, foreign regulatory agencies, must approve that site. These approvals would requireregulatory testing and compliance inspections. A new manufacturer or manufacturing site also would have to be educated in, or develop substantiallyequivalent processes for, production of our drugs and drug candidates. It may be difficult or impossible to transfer certain elements of a manufacturingprocess to a new manufacturer or for us to find a replacement manufacturer on acceptable terms quickly, or at all, either of which would delay or prevent ourability to develop drug candidates and commercialize any resulting drugs.We may not be able to successfully manufacture our drug candidates in sufficient quality and quantity, which would delay or prevent us fromdeveloping our drug candidates and commercializing resulting approved drugs, if any.To date, our drug candidates have been manufactured in quantities adequate for preclinical studies and early through late-stage clinical trials. In orderto conduct large scale clinical trials for a drug candidate and for commercialization of the resulting drug if that drug candidate is approved for sale, we willneed to manufacture some drug candidates in larger quantities. We may not be able to successfully repeat or increase the manufacturing capacity for any ofour drug candidates, whether in collaboration with third-party manufacturers or on our own, in a timely or cost-effective manner or at all. If a contractmanufacturer makes improvements in the manufacturing process for our drug candidates, we may not own, or may have to share, the intellectual propertyrights to those improvements. Significant changes or scale-up of manufacturing may require additional validation studies, which are costly and whichregulatory authorities must review and approve. In addition, quality issues may arise during those changes or scale-up activities because of the inherentproperties of a drug candidate itself or of a drug candidate in combination with other components added during the manufacturing and packaging process, orduring shipping and storage of the finished product or active pharmaceutical ingredients. If we are unable to successfully manufacture of any of our drugcandidates in sufficient quality and quantity, the development of that drug candidate and regulatory approval or commercial launch for any resulting drugsmay be delayed or there may be a shortage in supply, which could significantly harm our business. In addition, data demonstrating the stability of both drugsubstance and drug product, using the commercial manufacturing process and at commercial scale, are required for marketing applications. Failure to producedrug substance and drug products in a timely manner and obtain stability data could result in delay of submission of marketing applications.The mechanisms of action of our drug candidates are unproven, and we do not know whether we will be able to develop any drug of commercial value.We have discovered and are currently developing drug candidates that have what we believe are novel mechanisms of action directed againstcytoskeletal targets, and intend to continue to do so. Because no currently approved drugs appear to operate via the same biochemical mechanisms as ourcompounds, we cannot be certain that our drug candidates will result in commercially viable drugs that safely and effectively treat the indications for whichwe intend to develop them. The results we have seen for our compounds in preclinical models may not translate into similar results in humans, and results ofearly clinical trials in humans may not be predictive of the results of larger clinical trials that may later be conducted with our drug candidates. Even if we aresuccessful in developing and receiving regulatory approval for a drug candidate for the treatment of a particular disease, we cannot be certain that it will beaccepted by prescribers or be reimbursed by insurers or that we will also be able to develop and receive regulatory approval for that or other drug candidatesfor the treatment of other diseases. If we or our partners are unable to successfully develop and commercialize our drug candidates, our business will bematerially harmed.Our success depends substantially upon our ability to obtain and maintain intellectual property protection relating to our drug candidates, compoundsand research technologies.We own, or hold exclusive licenses to, a number of U.S. and foreign patents and patent applications directed to our drug candidates, compounds andresearch technologies. Our success depends on our ability to obtain 40Table of Contentspatent protection both in the United States and in other countries for our drug candidates, their methods of manufacture and use, and our technologies. Ourability to protect our drug candidates, compounds and technologies from unauthorized or infringing use by third parties depends substantially on our abilityto obtain and enforce our patents. If our issued patents and patent applications, if granted, do not adequately describe, enable or otherwise provide coverageof our technologies and drug candidates, including tirasemtiv, CK-2127107 and omecamtiv mecarbil, we or our licensees would not be able to exclude othersfrom developing or commercializing these drug candidates. Furthermore, the degree of future protection of our proprietary rights is uncertain because legalmeans may not adequately protect our rights or permit us to gain or keep our competitive advantage.Due to evolving legal standards relating to the patentability, validity and enforceability of patents covering pharmaceutical inventions and the claimscope of these patents, our ability to enforce our existing patents and to obtain and enforce patents that may issue from any pending or future patentapplications is uncertain and involves complex legal, scientific and factual questions. The standards which the U.S. Patent and Trademark Office and itsforeign counterparts use to grant patents are not always applied predictably or uniformly and are subject to change. To date, no consistent policy has emergedregarding the breadth of claims allowed in biotechnology and pharmaceutical patents. Thus, we cannot be sure that any patents will issue from any pendingor future patent applications owned by or licensed to us. Even if patents do issue, we cannot be sure that the claims of these patents will be held valid orenforceable by a court of law, will provide us with any significant protection against competitive products, or will afford us a commercial advantage overcompetitive products. In particular: • we or our licensors might not have been the first to make the inventions covered by each of our pending patent applications and issued patents; • we or our licensors might not have been the first to file patent applications for the inventions covered by our pending patent applications and issuedpatents; • others may independently develop similar or alternative technologies or duplicate any of our technologies without infringing our intellectualproperty rights; • some or all of our or our licensors’ pending patent applications may not result in issued patents or the claims that issue may be narrow in scope andnot provide us with competitive advantages; • our and our licensors’ issued patents may not provide a basis for commercially viable drugs or therapies or may be challenged and invalidated bythird parties; • our or our licensors’ patent applications or patents may be subject to interference, opposition or similar administrative proceedings that may resultin a reduction in their scope or their loss altogether; • we may not develop additional proprietary technologies or drug candidates that are patentable; or • the patents of others may prevent us or our partners from discovering, developing or commercializing our drug candidates.Patent protection is afforded on a country-by-country basis. Some foreign jurisdictions do not protect intellectual property rights to the same extent asin the United States. Many companies have encountered significant difficulties in protecting and defending intellectual property rights in foreignjurisdictions. Some of our development efforts are performed in countries outside of the United States through third party contractors. We may not be able toeffectively monitor and assess intellectual property developed by these contractors. We therefore may not be able to effectively protect this intellectualproperty and could lose potentially valuable intellectual property rights. In addition, the legal protection afforded to inventors and owners of intellectualproperty in countries outside of the United States may not be as protective of intellectual property rights as in the United States. Therefore, we may be unableto acquire and protect intellectual property developed by these contractors to the same extent as if these development activities were being conducted in theUnited States. If we encounter difficulties in protecting our intellectual property rights in foreign jurisdictions, our business prospects could be substantiallyharmed. 41Table of ContentsWe rely on intellectual property assignment agreements with our corporate partners, employees, consultants, scientific advisors and other collaboratorsto grant us ownership of new intellectual property that is developed. These agreements may not result in the effective assignment to us of that intellectualproperty. As a result, our ownership of key intellectual property could be compromised.Changes in either the patent laws or their interpretation in the United States or other countries may diminish the value of our intellectual property orour ability to obtain patents. For example, the America Invents Act of 2011 may affect the scope, strength and enforceability of our patent rights in the UnitedStates or the nature of proceedings which may be brought by us related to our patent rights in the United States.If one or more products resulting from our drug candidates is approved for sale by the FDA and we do not have adequate intellectual propertyprotection for those products, competitors could duplicate them for approval and sale in the United States without repeating the extensive testing required ofus or our partners to obtain FDA approval. Regardless of any patent protection, under current law, an application for a generic version of a new chemicalentity cannot be approved until at least five years after the FDA has approved the original product. When that period expires, or if that period is altered, theFDA could approve a generic version of our product regardless of our patent protection. An applicant for a generic version of our product may only berequired to conduct a relatively inexpensive study to show that its product is bioequivalent to our product, and may not have to repeat the lengthy andexpensive clinical trials that we or our partners conducted to demonstrate that the product is safe and effective. In the absence of adequate patent protectionfor our products in other countries, competitors may similarly be able to obtain regulatory approval in those countries of generic versions of our products.We also rely on trade secrets to protect our technology, particularly where we believe patent protection is not appropriate or obtainable. However, tradesecrets are often difficult to protect, especially outside of the United States. While we endeavor to use reasonable efforts to protect our trade secrets, our or ourpartners’ employees, consultants, contractors or scientific and other advisors may unintentionally or willfully disclose our information to competitors. Inaddition, confidentiality agreements, if any, executed by those individuals may not be enforceable or provide meaningful protection for our trade secrets orother proprietary information in the event of unauthorized use or disclosure. Pursuing a claim that a third party had illegally obtained and was using our tradesecrets would be expensive and time-consuming, and the outcome would be unpredictable. Even if we are able to maintain our trade secrets as confidential, ifour competitors independently develop information equivalent or similar to our trade secrets, our business could be harmed.If we are not able to defend the patent or trade secret protection position of our technologies and drug candidates, then we will not be able to excludecompetitors from developing or marketing competing drugs, and we may not generate enough revenue from product sales to justify the cost of developmentof our drugs or to achieve or maintain profitability.If we are sued for infringing third party intellectual property rights, it will be costly and time-consuming, and an unfavorable outcome could have asignificant adverse effect on our business.Our ability to commercialize drugs depends on our ability to use, manufacture and sell those drugs without infringing the patents or other proprietaryrights of third parties. Numerous U.S. and foreign issued patents and pending patent applications owned by third parties exist in the therapeutic areas inwhich we are developing drug candidates and seeking new potential drug candidates. In addition, because patent applications can take several years to issue,there may be currently pending applications, unknown to us, which could later result in issued patents that our activities with our drug candidates couldinfringe. There may also be existing patents, unknown to us, that our activities with our drug candidates could infringe.Other future products of ours may be impacted by patents of companies engaged in competitive programs with significantly greater resources. Furtherdevelopment of these products could be impacted by these patents and result in significant legal fees. 42Table of ContentsIf a third party claims that our actions infringe its patents or other proprietary rights, we could face a number of issues that could seriously harm ourcompetitive position, including, but not limited to: • infringement and other intellectual property claims that, even if meritless, can be costly and time-consuming to litigate, delay the regulatoryapproval process and divert management’s attention from our core business operations; • substantial damages for past infringement which we may have to pay if a court determines that our drugs or technologies infringe a third party’spatent or other proprietary rights; • a court prohibiting us from selling or licensing our drugs or technologies unless the holder licenses the patent or other proprietary rights to us,which it is not required to do; and • if a license is available from a holder, we may have to pay substantial royalties or grant cross-licenses to our patents or other proprietary rights.If any of these events occur, it could significantly harm our business and negatively affect our stock price.We may undertake infringement or other legal proceedings against third parties, causing us to spend substantial resources on litigation and exposingour own intellectual property portfolio to challenge.Third parties may infringe our patents. To prevent infringement or unauthorized use, we may need to file infringement suits, which are expensive andtime-consuming. In an infringement proceeding, a court may decide that one or more of our patents is invalid, unenforceable, or both. In this case, thirdparties may be able to use our technology without paying licensing fees or royalties. Even if the validity of our patents is upheld, a court may refuse to stopthe other party from using the technology at issue on the ground that the other party’s activities are not covered by our patents. Policing unauthorized use ofour intellectual property is difficult, and we may not be able to prevent misappropriation of our proprietary rights, particularly in countries where the lawsmay not protect such rights as fully as in the United States. In addition, third parties may affirmatively challenge our rights to, or the scope or validity of, ourpatent rights.We may become involved in disputes with our strategic partners over intellectual property ownership, and publications by our research collaboratorsand clinical investigators could impair our ability to obtain patent protection or protect our proprietary information, either of which would have asignificant impact on our business.Inventions discovered under our current or future strategic alliance agreements may become jointly owned by our strategic partners and us in somecases, and the exclusive property of one of us in other cases. Under some circumstances, it may be difficult to determine who owns a particular invention orwhether it is jointly owned, and disputes could arise regarding ownership or use of those inventions. These disputes could be costly and time-consuming, andan unfavorable outcome could have a significant adverse effect on our business if we were not able to protect or license rights to these inventions. Inaddition, our research collaborators and clinical investigators generally have contractual rights to publish data arising from their work. Publications by ourresearch collaborators and clinical investigators relating to our research and development programs, either with or without our consent, could benefit ourcurrent or potential competitors and may impair our ability to obtain patent protection or protect our proprietary information, which could significantly harmour business.We may be subject to claims that we or our employees have wrongfully used or disclosed trade secrets of their former employers.Many of our employees were previously employed at universities or other biotechnology or pharmaceutical companies, including our competitors orpotential competitors. Although no claims against us are currently pending, we may be subject to claims that these employees or we have inadvertently orotherwise used or disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to 43Table of Contentsdefend against these claims. If we fail in defending these claims, in addition to paying monetary damages, we may lose valuable intellectual property rightsor personnel. A loss of key research personnel or their work product could hamper or prevent our ability to develop and commercialize certain potentialdrugs, which could significantly harm our business. Even if we are successful in defending against these claims, litigation could result in substantial costsand distract management.Our competitors may develop drugs that are less expensive, safer or more effective than ours, which may diminish or eliminate the commercial successof any drugs that we may commercialize.We compete with companies that have developed drugs or are developing drug candidates for cardiovascular diseases, diseases and conditionsassociated with muscle weakness or wasting and other diseases for which our drug candidates may be useful treatments. For example, if tirasemtiv is approvedfor marketing by the FDA or other regulatory authorities for the treatment of ALS, it may then compete with other potential new therapies for ALS that arecurrently being developed by companies such as Neuraltus Pharmaceuticals, Inc., which is developing NP001; Ionis Pharmaceuticals, Inc., (in collaborationwith Biogen Inc.), which is developing Ionis-SOD1Rx; AB Science, which is developing masitinib; Mitsubishi Tanabe Pharma Corporation, which isdeveloping Radicut (edaravone); Eisai Co. Ltd., which is developing mecobalamin; Orion Pharma (UK) Ltd., which is developing levosimendan; GenervonBiopharmaceuticals, LLC, which is developing GM604; Q Therapeutics, which is developing Q Cells; Genentech, Inc., which is developing GCD-0134;MediciNova, Inc. which is developing ibudilast, Edison Pharma which is developing EPI-589, and VM BioPharm which is developing VM202. In addition,BrainStorm Cell Therapeutics and Neuralstem, Inc. are each conducting clinical development of stem cell therapies for the potential treatment of ALS.Tirasemtiv may also compete with Rilutek (riluzole), manufactured by Sanofi and several generics manufacturers including Apotex Corp., GlenmarkGenerics, and Sun Pharmaceuticals.If CK-2127107 is approved by the FDA or other regulatory authorities for the potential treatment of SMA, potential competitors include Roche (incollaboration with PTC Therapeutics and Trophos SA), AveXis, Inc., Pfizer Inc., Ionis Pharmaceuticals, Inc., (in collaboration with Biogen Inc.) which ismarketed as Spinraza, Novartis AG and Bioblast Pharma, Ltd. Drugs that could compete with CK-2127107 could also compete against tirasemtiv in ALS orother neuromuscular diseases, should the appropriate clinical trials be conducted. If CK-2127107 is approved by the FDA for the potential treatment ofnon-neuromuscular indications associated with muscle weakness, potential competitors include Regeneron Pharmaceuticals, Inc. (in collaboration withSanofi), Eli Lilly and Company, Acceleron Pharma, Stealth Biotherapeutics, Scholar Rock, vTv Therapeutics, Summit Therapeutics, Pfizer Inc., and Novartis(in collaboration with Morphosys AG).If omecamtiv mecarbil is approved for marketing by the FDA or other regulatory authorities for the treatment of heart failure, it would compete againstother drugs used for the treatment of acute and chronic heart failure. These include generic drugs, such as milrinone, dobutamine or digoxin and brandeddrugs such as Natrecor (nesiritide), Corlanor (ivabradine), and Entresto. Omecamtiv mecarbil could also potentially compete against other novel drugcandidates and therapies in development, such as those being developed by ARCA biopharma, Inc.; Novartis; Bayer, Capricor Therapeutics, Inc.,Cardiorentis AG, Ono Pharmaceutical Company, Juventas Therapeutics, ARMGO Pharma, Inc, Trevena, Inc. in partnership with Forest Laboratories, Inc.,Stealth Biotherapeutics, Cardioxyl Pharmaceuticals, Inc., Zensun Sci & Tech, Ltd., and Tenax Therapeutics (formerly known as Oxygen Biotherapeutics,Inc.). In addition, there are a number of medical devices both marketed and in development for the potential treatment of heart failure.Our competitors may: • develop drug candidates and market drugs that are less expensive or more effective than our future drugs; • commercialize competing drugs before we or our partners can launch any drugs developed from our drug candidates; • hold or obtain proprietary rights that could prevent us from commercializing our products; 44Table of Contents • initiate or withstand substantial price competition more successfully than we can; • more successfully recruit skilled scientific workers and management from the limited pool of available talent; • more effectively negotiate third-party licenses and strategic alliances; • take advantage of acquisition or other opportunities more readily than we can; • develop drug candidates and market drugs that increase the levels of safety or efficacy that our drug candidates will need to show in order to obtainregulatory approval; or • introduce therapies or market drugs that render the market opportunity for our potential drugs obsolete.We will compete for market share against large pharmaceutical and biotechnology companies and smaller companies that are collaborating with largerpharmaceutical companies, new companies, academic institutions, government agencies and other public and private research organizations. Many of thesecompetitors, either alone or together with their partners, may develop new drug candidates that will compete with ours. Many of these competitors have largerresearch and development programs or substantially greater financial resources than we do. Our competitors may also have significantly greater experiencein: • developing drug candidates; • undertaking preclinical testing and clinical trials; • building relationships with key customers and opinion-leading physicians; • obtaining and maintaining FDA and other regulatory approvals of drug candidates; • formulating and manufacturing drugs; and • launching, marketing and selling drugs.If our competitors market drugs that are less expensive, safer or more efficacious than our potential drugs, or that reach the market sooner than ourpotential drugs, we may not achieve commercial success. In addition, the life sciences industry is characterized by rapid technological change. If we fail tostay at the forefront of technological change, we may be unable to compete effectively. Our competitors may render our technologies obsolete by improvingexisting technological approaches or developing new or different approaches, potentially eliminating the advantages in our drug discovery process that webelieve we derive from our research approach and proprietary technologies.We have been granted orphan designations in the U.S. and in the E.U. for tirasemtiv; however, there can be no guarantee that we will receive orphanapproval for tirasemtiv, nor that we will be able to prevent third parties from developing and commercializing products that are competitive totirasemtiv.We have been granted orphan drug designation in the U.S. by the FDA and orphan medicinal product designation by the European Medicines Agency,in each case for tirasemtiv for the potential treatment of ALS. In the U.S., upon approval from the FDA of an NDA, products granted orphan drug approval aregenerally provided with seven years of marketing exclusivity in the U.S., meaning the FDA will generally not approve applications for other productcandidates for the same orphan indication that contain the same active ingredient. Even if we are the first to obtain approval of an orphan product and aregranted exclusivity in the U.S., there are limited circumstances under which a later competitor product may be approved for the same indication during theseven-year period of marketing exclusivity, such as if the later product is shown to be clinically superior to our product or due to an inability to assure asufficient quantity of the orphan drug.Orphan medicinal product status in Europe Union can provide up to 10 years of marketing exclusivity, meaning that another application for marketingauthorization of a later similar medicinal product for the same 45Table of Contentstherapeutic indication will generally not be approved in the European Union. Although we may have drug candidates that may obtain orphan drugexclusivity in Europe, the orphan approval and associated exclusivity period may be modified for several reasons, including a significant change to theorphan medicinal product designations or approval criteria after-market authorization of the orphan product (e.g., product profitability exceeds the criteria fororphan drug designation), problems with the production or supply of the orphan drug or a competitor drug, although similar, is safer, more effective orotherwise clinically superior than the initial orphan drug.We are not guaranteed to maintain orphan status for tirasemtiv or to receive orphan status for tirasemtiv for any other indication or for any of our otherdrug candidates for any indication. If our drug candidates that are granted orphan status were to lose their status as orphan drugs or the marketing exclusivityprovided for them in the U.S. or the European Union, our business and results of operations could be materially adversely affected. While orphan status forany of our products, if granted or maintained, would provide market exclusivity in the U.S. and the European Union for the time periods specified above, wewould not be able to exclude other companies from manufacturing and/or selling products using the same active ingredient for the same indication beyondthe exclusivity period applicable to our product on the basis of orphan drug status. Moreover, we cannot guarantee that another company will not receiveapproval before we do of an orphan drug application in the U.S. or the European Union for a product candidate that has the same active ingredient or is asimilar medicinal product for the same indication as any of our drug candidates for which we plan to file for orphan designation and status. If that were tohappen, our orphan drug applications for our drug candidate for that indication may not be approved until the competing company’s period of exclusivityhas expired in the U.S. or the European Union, as applicable. Further, application of the orphan drug regulations in the U.S. and Europe is uncertain, and wecannot predict how the respective regulatory bodies will interpret and apply the regulations to our or our competitors’ products.Our failure to attract and retain skilled personnel could impair our drug development and commercialization activities.Our business depends on the performance of our senior management and key scientific and technical personnel. The loss of the services of any memberof our senior management or key scientific or technical staff may significantly delay or prevent the achievement of drug development and other businessobjectives by diverting management’s attention to transition matters and identifying suitable replacements. We also rely on consultants and advisors to assistus in formulating our research and development strategy. All of our consultants and advisors are either self-employed or employed by other organizations,and they may have conflicts of interest or other commitments, such as consulting or advisory contracts with other organizations, that may affect their abilityto contribute to us. In addition, if and as our business grows, we will need to recruit additional executive management and scientific and technical personnel.There is intense competition for skilled executives and employees with relevant scientific and technical expertise, and this competition is likely to continue.Our inability to attract and retain sufficient scientific, technical and managerial personnel could limit or delay our product development activities, whichwould adversely affect the development of our drug candidates and commercialization of our potential drugs and growth of our business.Any future workforce and expense reductions may have an adverse impact on our internal programs and our ability to hire and retain skilled personnel.Our future success will depend in large part upon our ability to attract and retain highly skilled personnel. In light of our continued need for fundingand cost control, we may be required to implement future workforce and expense reductions, which could further limit our research and developmentactivities. For example, in October 2011, we reduced our workforce by approximately 18% in order to reduce expenses and to focus resources primarily onour later-stage development programs for tirasemtiv and omecamtiv mecarbil and certain other research and development programs also directed to musclebiology. These headcount reductions and the cost control measures we have implemented may negatively affect our productivity and limit our research and 46Table of Contentsdevelopment activities. We may have difficulty retaining and attracting such personnel as a result of a perceived risk of future workforce reductions. Inaddition, the implementation of any additional workforce or expense reduction programs may divert the efforts of our management team and other keyemployees, which could adversely affect our business.We may expand our development and clinical research capabilities and, as a result, we may encounter difficulties in managing our growth, which coulddisrupt our operations.We may have growth in our expenditures, the number of our employees and the scope of our operations, in particular with respect to those drugcandidates that we elect to develop or commercialize independently or together with a partner. To manage our anticipated future growth, we must continue toimplement and improve our managerial, operational and financial systems, expand our facilities and continue to recruit and train additional qualifiedpersonnel. Due to our limited resources, we may not be able to effectively manage the expansion of our operations or recruit and train additional qualifiedpersonnel. The physical expansion of our operations may lead to significant costs and may divert our management and business development resources. Anyinability to manage growth could delay the execution of our business plans or disrupt our operations.We currently have no sales or marketing capabilities and, if we are unable to enter into or maintain strategic alliances with marketing partners or todevelop our own sales and marketing capabilities, we may not be successful in commercializing our potential drugs.We currently have no sales, marketing or distribution capabilities. We plan to commercialize drugs that can be effectively marketed and sold inconcentrated markets that do not require a large sales force to be competitive. To achieve this goal, we will need to establish our own specialized sales forceand marketing organization with technical expertise and supporting distribution capabilities. Developing such an organization is expensive and time-consuming and could delay a product launch. In addition, we may not be able to develop this capacity efficiently, cost-effectively or at all, which couldmake us unable to commercialize our drugs. If we determine not to market our drugs on our own, we will depend on strategic alliances with third parties, suchas Amgen and Astellas, which have established distribution systems and direct sales forces to commercialize them. If we are unable to enter into sucharrangements on acceptable terms, we may not be able to successfully commercialize these drugs. To the extent that we are not successful in commercializingany drugs ourselves or through a strategic alliance, our product revenues and business will suffer and our stock price would decrease.Our internal computer systems, or those of our CROs, CMOs, or other contractors or consultants, may fail or suffer security breaches, which could resultin a material disruption of our drug development programs.Despite the implementation of security measures, our internal computer systems and those of our CROs, CMOs, and other contractors and consultantsare vulnerable to damage from computer viruses, unauthorized access, natural disasters, terrorism, war and telecommunication and electrical failures. Whilewe have not experienced any such system failure, accident or security breach to date, if such an event were to occur and cause interruptions in our operations,it could result in a material disruption of our drug development programs. For example, the loss of clinical study data from completed or ongoing clinicalstudies for any of our drug candidates could result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce thedata. To the extent that any disruption or security breach were to result in a loss of or damage to our data or applications, or inappropriate disclosure ofconfidential or proprietary information, we could incur liability and the further development of our product candidates could be delayed. 47Table of ContentsWe are obligated to develop and maintain proper and effective internal control over financial reporting. In the future, we may not complete ourexecution of our internal control over financial reporting in a timely manner, or these internal controls may not be determined to be effective, whichmay result in additional material misstatements in our consolidated financial statements and may adversely affect investor confidence in our companyand, as a result, the value of our common stock.We are required, pursuant to Section 404 of the Sarbanes-Oxley Act, to furnish a report by management on, among other things, the effectiveness of ourinternal control over financial reporting.Complying with Section 404 requires a rigorous compliance program as well as adequate time and resources. We may not be able to complete ourinternal control evaluation, testing and any required remediation in a timely fashion. Additionally, if we identify one or more material weaknesses in ourinternal control over financial reporting, we will not be able to assert that our internal controls are effective. For example, our management concluded that ourinternal controls over financial reporting were not effective as of September 30, 2016, because a material weakness existed in our internal control overfinancial reporting related to research and development expenses associated with the review of clinical trial expenses incurred under our clinical researchorganization trial agreements, including in part, our review of information received from third party service providers that is used in the operation of thiscontrol. Even though we remediated this material weakness as of December 31, 2016, if other material weaknesses are identified in the future or we are notable to comply with the requirements of Section 404 in a timely manner, our reported financial results could be materially misstated, we would receive anadverse opinion regarding our internal controls over financial reporting from our independent registered public accounting firm, and we could be subject toinvestigations or sanctions by regulatory authorities, which would require additional financial and management resources, and the value of our commonstock could decline. In addition, because we have concluded that our internal control over financial reporting were not effective as of September 30, 2016,and to the extent we identify future weaknesses or deficiencies, there could be material misstatements in our consolidated financial statements and we couldfail to meet our financial reporting obligations. As a result, our ability to obtain additional financing, or obtain additional financing on favorable terms,could be materially and adversely affected which, in turn, could materially and adversely affect our business, our financial condition and the value of ourcommon stock. If we are unable to assert that our internal control over financial reporting is effective in the future, or if our independent registered publicaccounting firm is unable to express an opinion or expresses an adverse opinion on the effectiveness of our internal controls in the future, investor confidencein the accuracy and completeness of our financial reports could be further eroded, which would have a material adverse effect on the price of our commonstock.Our reported financial results may be adversely affected by changes in accounting principles generally accepted in the U.S.We prepare our financial statements in conformity with accounting principles generally accepted in the U.S. These accounting principles are subject tointerpretation by the Financial Accounting Standards Board (“FASB”) and the Securities and Exchange Commission. A change in these policies orinterpretations could have a significant effect on our reported financial results, may retroactively affect previously reported results, could cause unexpectedfinancial reporting fluctuations, and may require us to make costly changes to our operational processes and accounting systems. In May 2014, the FASBissued ASU 2014-09, Revenue from Contracts with Customers which supersedes nearly all existing U.S. GAAP revenue recognition guidance. The newstandard will become effective for us on January 1, 2018. Early application is permitted to the original effective date of January 1, 2017. Although we arecontinuing to assess all potential impacts of the standard on our financial statements or disclosures, it could change the way we account for certain of ourrevenue transactions, including the timing of recognition of our license and collaboration revenues. Adoption of the standard could have a significant impacton our financial statements and may retroactively affect the accounting treatment of transactions completed before adoption. See “Note 1 — RecentAccounting Pronouncements” for additional discussion of the accounting changes. 48Table of ContentsRisks Related To Our IndustryThe regulatory approval process is expensive, time-consuming and uncertain and may prevent our partners or us from obtaining approvals tocommercialize some or all of our drug candidates.The research, testing, manufacturing, selling and marketing of drugs are subject to extensive regulation by the FDA and other regulatory authorities inthe United States and other countries, and regulations differ from country to country. Neither we nor our partners are permitted to market our potential drugsin the United States until we receive approval of a new drug application (“NDA”) from the FDA. Neither we nor our partners have received NDA or othermarketing approval for any of our drug candidates.Obtaining NDA approval is a lengthy, expensive and uncertain process. In addition, failure to comply with FDA and other applicable foreign and U.S.regulatory requirements may subject us to administrative or judicially imposed sanctions. These include warning letters, civil and criminal penalties,injunctions, product seizure or detention, product recalls, total or partial suspension of production, and refusal to approve pending NDAs or supplements toapproved NDAs.Regulatory approval of an NDA or NDA supplement is never guaranteed, and the approval process typically takes several years and is extremelyexpensive. The FDA and foreign regulatory agencies also have substantial discretion in the drug approval process, and the guidance and advice issued bysuch agencies is subject to change at any time. Despite the time and efforts exerted, failure can occur at any stage, and we may encounter problems that causeus to abandon clinical trials or to repeat or perform additional preclinical testing and clinical trials. The number and focus of preclinical studies and clinicaltrials that will be required for approval by the FDA and foreign regulatory agencies varies depending on the drug candidate, the disease or condition that thedrug candidate is designed to address, and the regulations applicable to any particular drug candidate. In addition, the FDA may require that a proposed RiskEvaluation and Mitigation Strategy, also known as a REMS, be submitted as part of an NDA if the FDA determines that it is necessary to ensure that thebenefits of the drug outweigh its risks. The FDA and foreign regulatory agencies can delay, limit or deny approval of a drug candidate for many reasons,including, but not limited to: • they might determine that a drug candidate is not safe or effective; • they might not find the data from nonclinical testing and clinical trials sufficient and could request that additional trials be performed; • they might not approve our, our partner’s or the contract manufacturer’s processes or facilities; or • they might change their approval policies or adopt new regulations.Even if we receive regulatory approval to manufacture and sell a drug in a particular regulatory jurisdiction, other jurisdictions’ regulatory authoritiesmay not approve that drug for manufacture and sale. If we or our partners fail to receive and maintain regulatory approval for the sale of any drugs resultingfrom our drug candidates, it would significantly harm our business and negatively affect our stock price.If we or our partners receive regulatory approval for our drug candidates, we or they will be subject to ongoing obligations to and continued regulatoryreview by the FDA and foreign regulatory agencies, and may be subject to additional post-marketing obligations, all of which may result in significantexpense and limit commercialization of our potential drugs.Any regulatory approvals that we or our partners receive for our drug candidates may be subject to limitations on the indicated uses for which the drugmay be marketed or require potentially costly post-marketing follow-up studies or compliance with a REMS. In addition, if the FDA or foreign regulatoryagencies approves any of our drug candidates, the labeling, packaging, adverse event reporting, storage, advertising, promotion and record-keeping for thedrug will be subject to extensive regulatory requirements. The subsequent discovery of previously unknown problems with the drug, including adverseevents of unanticipated severity or frequency, or 49Table of Contentsthe discovery that adverse events or toxicities observed in preclinical research or clinical trials that were believed to be minor actually constitute much moreserious problems, may result in restrictions on the marketing of the drug or withdrawal of the drug from the market.The FDA and foreign regulatory agencies may change their policies and additional government regulations may be enacted that could prevent or delayregulatory approval of our drug candidates. We cannot predict the likelihood, nature or extent of adverse government regulation that may arise from futurelegislation or administrative action, either in the United States or abroad. If we are not able to maintain regulatory compliance, we might not be permitted tomarket our drugs and our business would suffer.If physicians and patients do not accept our drugs, we may be unable to generate significant revenue, if any.Even if our drug candidates obtain regulatory approval, the resulting drugs, if any, may not gain market acceptance among physicians, healthcarepayors, patients and the medical community. Even if the clinical safety and efficacy of drugs developed from our drug candidates are established for purposesof approval, physicians may elect not to recommend these drugs for a variety of reasons including, but not limited to: • introduction of competitive drugs to the market; • clinical safety and efficacy of alternative drugs or treatments; • cost-effectiveness; • availability of coverage and reimbursement from health maintenance organizations and other third-party payors; • convenience and ease of administration; • prevalence and severity of adverse events; • other potential disadvantages relative to alternative treatment methods; or • insufficient marketing and distribution support.If our drugs fail to achieve market acceptance, we may not be able to generate significant revenue and our business would suffer.The coverage, reimbursement status and pricing of newly approved drugs is uncertain and failure to obtain adequate coverage and reimbursementcould limit our ability to market any drugs we may develop and decrease our ability to generate revenue.Even if one or more of our drug candidates is approved for sale, the commercial success of our drugs in both domestic and international markets will besubstantially dependent on whether third-party coverage and reimbursement is available for our drugs by the medical profession for use by their patients,which is highly uncertain. Medicare, Medicaid, health maintenance organizations and other third-party payors are increasingly attempting to containhealthcare costs by limiting both coverage and the level of reimbursement of new drugs. As a result, they may not cover or provide adequate payment for ourdrugs. They may not view our drugs as cost-effective and reimbursement may not be available to consumers or may be insufficient to allow our drugs to bemarketed on a competitive basis. If we are unable to obtain adequate coverage and reimbursement for our drugs, our ability to generate revenue will beadversely affected. Likewise, current and future legislative or regulatory efforts to control or reduce healthcare costs or reform government healthcareprograms could result in lower prices or rejection of coverage and reimbursement for our potential drugs. Changes in coverage and reimbursement policies orhealthcare cost containment initiatives that limit or restrict reimbursement for any of our drug candidates that are approved could cause our potential futurerevenues to decline. In January 2017, Congress voted to adopt a budget resolution for fiscal year 2017, or the Budget Resolution, that authorizes the 50Table of Contentsimplementation of legislation that would repeal portions of Affordable Care Act. The Budget Resolution is not a law; however, it is widely viewed as the firststep toward the passage of legislation that would repeal certain aspects of Affordable Care Act. Further, on January 20, 2017, President Trump signed anExecutive Order directing federal agencies with authorities and responsibilities under Affordable Care Act to waive, defer, grant exemptions from, or delaythe implementation of any provision of Affordable Care Act that would impose a fiscal or regulatory burden on states, individuals, healthcare providers,health insurers, or manufacturers of pharmaceuticals or medical devices. Congress also could consider subsequent legislation to replace elements ofAffordable Care Act that are repealed.We may be subject to costly product liability or other liability claims and may not be able to obtain adequate insurance.The use of our drug candidates in clinical trials may result in adverse events. We cannot predict all the possible harms or adverse events that may resultfrom our clinical trials. We currently maintain limited product liability insurance. We may not have sufficient resources to pay for any liabilities resultingfrom a personal injury or other claim excluded from, or beyond the limit of, our insurance coverage. Our insurance does not cover third parties’ negligence ormalpractice, and our clinical investigators and sites may have inadequate insurance or none at all. In addition, in order to conduct clinical trials or otherwisecarry out our business, we may have to contractually assume liabilities for which we may not be insured. If we are unable to look to our own or a third party’sinsurance to pay claims against us, we may have to pay any arising costs and damages ourselves, which may be substantial.In addition, if we commercially launch drugs based on our drug candidates, we will face even greater exposure to product liability claims. This riskexists even with respect to those drugs that are approved for commercial sale by the FDA and foreign regulatory agencies and manufactured in licensed andregulated facilities. We intend to secure additional limited product liability insurance coverage for drugs that we commercialize, but may not be able toobtain such insurance on acceptable terms with adequate coverage, or at reasonable costs. Even if we are ultimately successful in product liability litigation,the litigation would consume substantial amounts of our financial and managerial resources and may create adverse publicity, all of which would impair ourability to generate sales of the affected product and our other potential drugs. Moreover, product recalls may be issued at our discretion or at the direction ofthe FDA and foreign regulatory agencies, other governmental agencies or other companies having regulatory control for drug sales. Product recalls aregenerally expensive and often have an adverse effect on the reputation of the drugs being recalled and of the drug’s developer or manufacturer.We may be required to indemnify third parties against damages and other liabilities arising out of our development, commercialization and otherbusiness activities, which could be costly and time-consuming and distract management. If third parties that have agreed to indemnify us against damagesand other liabilities arising from their activities do not fulfill their obligations, then we may be held responsible for those damages and other liabilities.Our relationships with customers, healthcare providers, clinical trial sites and professionals and third-party payors will be subject to applicable anti-kickback, fraud and abuse and other laws and regulations, which could expose us to criminal sanctions, civil penalties, contractual damages,reputational harm and diminished profits and future earnings.Healthcare providers, physicians and third-party payors play a primary role in the recommendation and prescription of any drug candidates for whichwe may obtain marketing approval. Our arrangements with customers, healthcare providers and professionals and third-party payors may expose us to broadlyapplicable fraud and abuse and other healthcare laws and regulations that may constrain the business or financial arrangements and relationships throughwhich we develop, and may market, sell and distribute, our products for 51Table of Contentswhich we obtain marketing approval. Restrictions under applicable federal and state healthcare laws and regulations, include, but are not limited to, thefollowing: • The federal healthcare anti-kickback statute prohibits, among other things, persons from knowingly and willfully soliciting, offering, receiving orproviding remuneration, directly or indirectly, in cash or in kind, to induce or reward either the referral of an individual for, or the purchase, order orrecommendation of, any good or service, for which payment may be made under federally funded healthcare programs such as Medicare andMedicaid. This statute has been broadly interpreted to apply to manufacturer arrangements with prescribers, purchasers and formulary managers,among others. Several other countries, including the United Kingdom, have enacted similar anti-kickback, fraud and abuse, and healthcare laws andregulations. • The federal False Claims Act imposes civil penalties, including civil whistleblower or qui tam actions, against individuals or entities for knowinglypresenting, or causing to be presented, to the federal government, claims for payment that are false or fraudulent or making a false statement toavoid, decrease or conceal an obligation to pay money to the federal government. The government and qui tam relators have brought False ClaimsAct actions against pharmaceutical companies on the theory that their practices have caused false claims to be submitted to the government. Thereis also a separate false claims provision imposing criminal penalties. • The federal Health Insurance Portability and Accountability Act of 1996, or HIPAA, as amended by the Health Information Technology forEconomic and Clinical Health Act, imposes criminal and civil liability for executing a scheme to defraud any healthcare benefit program. HIPAAalso imposes obligations, including mandatory contractual terms, with respect to safeguarding the privacy, security and transmission of individuallyidentifiable health information. HIPAA also imposes criminal liability for knowingly and willfully falsifying, concealing or covering up a materialfact or making any materially false statement in connection with the delivery of or payment for healthcare benefits, items or services. • The federal Physician Payments Sunshine Act requires manufacturers of drugs, devices, biologics and medical supplies to report to the Departmentof Health and Human Services information related to payments and other transfers of value made to or at the request of covered recipients, such asphysicians and teaching hospitals, and physician ownership and investment interests in such manufacturers. Payments made to physicians andresearch institutions for clinical trials are included within the ambit of this law. • Analogous state laws and regulations, such as state anti-kickback and false claims laws, may apply to sales or marketing arrangements and claimsinvolving healthcare items or services reimbursed by non-governmental third-party payors, including private insurers, and some state laws requirepharmaceutical companies to comply with the pharmaceutical industry’s voluntary compliance guidelines and the relevant compliance guidancepromulgated by the federal government in addition to requiring drug manufacturers to report information related to payments to physicians andother health care providers or marketing expenditures.Efforts to ensure that our business arrangements with third parties will comply with applicable healthcare laws and regulations will involve substantialcosts. It is possible that governmental authorities will conclude that our business practices may not comply with current or future statutes, regulations or caselaw involving applicable fraud and abuse or other healthcare laws and regulations. If our operations are found to be in violation of any of these laws or anyother governmental regulations that may apply to us, we may be subject to significant civil, criminal and administrative penalties, damages, fines, exclusionfrom government funded healthcare programs, such as Medicare and Medicaid, and the curtailment or restructuring of our operations. Exclusion, suspensionand debarment from government funded healthcare programs would significantly impact our ability to commercialize, sell or distribute any drug. If any of thephysicians or other providers or entities with whom we expect to do business are found to be not in compliance with applicable laws, they may be subject tocriminal, civil or administrative sanctions, including exclusions from government funded healthcare programs. 52Table of ContentsIn addition, health care providers in the United States, including research institutions from which we or our partners obtain patient information, aresubject to privacy rules under HIPAA and state and local privacy laws. In the European Union, these entities are subject to the Directive 95/46-EC of theEuropean Parliament on the protection of individuals with regard to the processing of personal data and individual European Union member statesimplementing additional legislation. Other countries have similar privacy legislation. We could face substantial penalties if we knowingly receiveindividually identifiable health information from a health care provider that has not satisfied the applicable privacy laws. In addition, certain privacy lawsand genetic testing laws may apply directly to our operations and/or those of our partners and may impose restrictions on the use and dissemination ofindividuals’ health information and use of biological samples.Responding to any claims relating to improper handling, storage or disposal of the hazardous chemicals and radioactive and biological materials weuse in our business could be time-consuming and costly.Our research and development processes involve the controlled use of hazardous materials, including chemicals and radioactive and biologicalmaterials. Our operations produce hazardous waste products. We cannot eliminate the risk of accidental contamination or discharge and any resultant injuryfrom those materials. Federal, state and local laws and regulations govern the use, manufacture, storage, handling and disposal of hazardous materials. Wemay be sued for any injury or contamination that results from our or third parties’ use of these materials. Compliance with environmental laws and regulationsis expensive, and current or future environmental regulations may impair our research, development and production activities.Our facilities in California are located near an earthquake fault, and an earthquake or other types of natural disasters, catastrophic events or resourceshortages could disrupt our operations and adversely affect our results.All of our facilities and our important documents and records, such as hard and electronic copies of our laboratory books and records for our drugcandidates and compounds and our electronic business records, are located in our corporate headquarters at a single location in South San Francisco,California near active earthquake zones. If a natural disaster, such as an earthquake or flood, a catastrophic event such as a disease pandemic or terroristattack, or a localized extended outage of critical utilities or transportation systems occurs, we could experience a significant business interruption. Ourpartners and other third parties on which we rely may also be subject to business interruptions from such events. In addition, California from time to time hasexperienced shortages of water, electric power and natural gas. Future shortages and conservation measures could disrupt our operations and cause expense,thus adversely affecting our business and financial results.Risks Related To an Investment in Our SecuritiesWe expect that our stock price will fluctuate significantly, and you may not be able to resell your shares at or at or above your investment price.The stock market, particularly in recent years, has experienced significant volatility, particularly with respect to pharmaceutical, biotechnology andother life sciences company stocks, which often does not relate to the operating performance of the companies represented by the stock. Factors that couldcause volatility in the market price of our common stock include, but are not limited to: • announcements concerning any of the clinical trials for our drug candidates, such as tirasemtiv for the potential treatment of ALS, CK-2127107 forthe potential treatment of SMA, COPD, ALS or other indications associated with muscle weakness and omecamtiv mecarbil for the potentialtreatment of heart failure (including, but not limited to, the timing of initiation or completion of such trials and the results of such trials, and delaysor discontinuations of such trials, including delays resulting from slower than expected or suspended patient enrollment or discontinuationsresulting from a failure to meet pre-defined clinical end points); • announcements concerning our strategic alliance with Amgen or Astellas or future strategic alliances; 53Table of Contents • failure or delays in entering additional drug candidates into clinical trials; • failure or discontinuation of any of our research programs; • issuance of new or changed securities analysts’ reports or recommendations; • failure or delay in establishing new strategic alliances, or the terms of those alliances; • market conditions in the pharmaceutical, biotechnology and other healthcare-related sectors; • actual or anticipated fluctuations in our quarterly financial and operating results; • developments or disputes concerning our intellectual property or other proprietary rights; • introduction of technological innovations or new products by us or our competitors; • issues in manufacturing, packaging, labeling and distribution of our drug candidates or drugs; • market acceptance of our drugs; • third-party healthcare coverage and reimbursement policies; • FDA or other U.S. or foreign regulatory actions affecting us or our industry; • litigation or public concern about the safety of our drug candidates or drugs; • additions or departures of key personnel; • substantial sales of our common stock by our existing stockholders, whether or not related to our performance; • automated trading activity by algorithmic and high-frequency trading programs; and • volatility in the stock prices of other companies in our industry or in the stock market generally.These and other external factors may cause the market price and demand for our common stock to fluctuate substantially, which may limit or preventinvestors from readily selling their shares of common stock and may otherwise negatively affect the liquidity of our common stock. In addition, when themarket price of a stock has been volatile, holders of that stock have instituted securities class action litigation against the company that issued the stock. Ifany of our stockholders brought a lawsuit against us, we could incur substantial costs defending the lawsuit. Such a lawsuit could also divert ourmanagement’s time and attention.If the ownership of our common stock continues to be highly concentrated, it may prevent you and other stockholders from influencing significantcorporate decisions and may result in conflicts of interest that could cause our stock price to decline.As of February 23, 2017, our executive officers, directors and their affiliates beneficially owned or controlled approximately 10.8% of the outstandingshares of our common stock (after giving effect to the exercise of all outstanding vested and unvested options, restricted stock units and warrants).Accordingly, these executive officers, directors and their affiliates, acting as a group, will have substantial influence over the outcome of corporate actionsrequiring stockholder approval, including the election of directors, any merger, consolidation or sale of all or substantially all of our assets or any othersignificant corporate transactions. These stockholders may also delay or prevent a change of control of us, even if such a change of control would benefit ourother stockholders. The significant concentration of stock ownership may adversely affect the trading price of our common stock due to investors’ perceptionthat conflicts of interest may exist or arise.Volatility in the stock prices of other companies may contribute to volatility in our stock price.The stock market in general, and the NASDAQ stock exchanges and the market for technology companies in particular, have experienced significantprice and volume fluctuations that have often been unrelated or 54Table of Contentsdisproportionate to the operating performance of those companies. Further, there has been particular volatility in the market prices of securities of early stageand clinical stage life sciences companies. These broad market and industry factors may seriously harm the market price of our common stock, regardless ofour operating performance. In the past, following periods of volatility in the market price of a company’s securities, securities class action litigation has oftenbeen instituted. A securities class action suit against us could result in substantial costs, potential liabilities and the diversion of management’s attention andresources, and could harm our reputation and business.Our common stock is thinly traded and there may not be an active, liquid trading market for our common stock.There is no guarantee that an active trading market for our common stock will be maintained on NASDAQ, or that the volume of trading will besufficient to allow for timely trades. Investors may not be able to sell their shares quickly or at the latest market price if trading in our stock is not active or iftrading volume is limited. In addition, if trading volume in our common stock is limited, trades of relatively small numbers of shares may have adisproportionate effect on the market price of our common stock.Our stockholders will experience substantial additional dilution if outstanding options or warrants are exercised for common stock.As of February 23, 2017, there were 4,205,072 shares of common stock issuable upon the exercise of warrants, having a weighted average exercise priceof $5.31 per share, and 5,294,149 shares of common stock issuable upon the exercise of stock options outstanding, having a weighted average exercise priceof $10.14 per share. The exercise of outstanding options or warrants for common stock would be substantially dilutive to the outstanding shares of commonstock. Any dilution or potential dilution may cause our stockholders to sell their shares, which would contribute to a downward movement in the stock priceof our common stock.Ownership changes may limit our ability to use our net operating losses and tax credits in the future.In general, under Section 382 of the Internal Revenue Code (“Section 382”), a corporation that undergoes an ‘ownership change’ is subject tolimitations on its ability to utilize its pre-change net operating losses and tax credits to offset future taxable income. We have performed a Section 382analysis as of December 31, 2016 and do not believe that we have experienced an ownership change since 2006. A portion of our existing net operatinglosses and tax credits are subject to limitations arising from previous ownership changes. Future changes in our stock ownership, some of which are outside ofour control, could result in an ownership change under Section 382 and result in additional limitations. We intend to continue to monitor public filings madeby third parties with the SEC to assess whether an ownership change under Section 382 has occurred. Our ability to accurately assess any such ownershipchange is limited by the timeliness and accuracy of these public filings.Evolving regulation of corporate governance and public disclosure may result in additional expenses, use of resources and continuing uncertainty.Changing laws, regulations and standards relating to corporate governance and public disclosure, including the Sarbanes-Oxley Act of 2002, theDodd-Frank Wall Street Reform and Consumer Protection Act of 2010 and new SEC regulations and NASDAQ Stock Market LLC rules create uncertainty forpublic companies. We regularly evaluate and monitor developments with respect to new and proposed laws, regulations and standards. We cannot accuratelypredict or estimate the amount of the additional costs we may incur in connection with complying with such laws, regulations and standards or the timing ofthese costs. For example, compliance with the internal control requirements of Section 404 of the Sarbanes-Oxley Act has to date required us to commitsignificant resources to document and test the adequacy of our internal control over financial reporting. We can provide no assurance as to conclusions ofmanagement or by our independent registered public accounting firm with respect to the effectiveness of our internal control over financial reporting in thefuture. In addition, the SEC 55Table of Contentshas adopted regulations that require us to file corporate financial statement information in an interactive data format known as XBRL. We may incursignificant costs and need to invest considerable resources to remain in compliance with these regulations.These new or changed laws, regulations and standards are subject to varying interpretations, in many cases due to their lack of specificity, and, as aresult, their application in practice may evolve over time as new guidance is provided by regulatory and governing bodies. This could result in continuinguncertainty regarding compliance matters and higher costs necessitated by ongoing revisions to disclosure and governance practices.We intend to maintain high standards of corporate governance and public disclosure. As a result, we intend to invest the resources necessary to complywith evolving laws, regulations and standards, and this investment may result in increased general and administrative expenses and a diversion ofmanagement time and attention from revenue-generating activities to compliance activities. If our efforts to comply with new or changed laws, regulationsand standards differ from the activities intended by regulatory or governing bodies, due to ambiguities related to practice or otherwise, regulatory authoritiesmay initiate legal proceedings against us, which could be costly and time-consuming, and our reputation and business may be harmed.We have never paid dividends on our capital stock, and we do not anticipate paying any cash dividends in the foreseeable future.We have paid no cash dividends on any of our classes of capital stock to date and we currently intend to retain our future earnings, if any, to fund thedevelopment and growth of our businesses. In addition, the terms of existing or any future debts may preclude us from paying these dividends.Item 1B. Unresolved Staff CommentsNone.Item 2. PropertiesOur facilities consist of approximately 81,587 square feet of research and office space. We lease 50,195 square feet located at 280 East Grand Avenue,and 31,392 square feet at 256 East Grand Avenue, in South San Francisco, California until 2018 with an option to renew the lease for an additional threeyears. We believe that these facilities are suitable and adequate for our current needs.Item 3. Legal ProceedingsOn November 28, 2014, Pharm-Olam International, Ltd. (“Pharm-Olam”) filed a lawsuit in the U.S. District Court for the Middle District of NorthCarolina, captioned Pharm-Olam International, Ltd. v. Cytokinetics, Inc. and Datatrak International, Inc., Civil Action No. 1:14-cv-01000 (the “NorthCarolina Lawsuit”) in connection with its performance as the Contract Research Organization for the BENEFIT-ALS clinical trial. On September 16, 2015,the U.S. District Court for the Middle District of North Carolina dismissed the North Carolina lawsuit.On December 1, 2014, we filed a lawsuit in the U.S. District Court for the Northern District of California, captioned Cytokinetics, Inc. v. Pharm-OlamInternational, Ltd., Case No. 3:14-cv-05256-JCS (the “California Lawsuit”). This lawsuit alleged fraudulent inducement, breach of contract and negligenceby Pharm-Olam in connection with its performance as the Contract Research Organization for the BENEFIT-ALS clinical trial. We sought monetary damagesfrom Pharm-Olam. Pharm-Olam answered the complaint on March 24, 2015. Datatrak International, Inc. (“Datatrak”) filed a motion to intervene as a newparty plaintiff on June 5, 2015, which the court granted on July 1, 2015. Datatrak sought a declaratory judgment that the indemnification provision of theagreement between Pharm-Olam and Datatrak did not require Datatrak to indemnify Pharm-Olam for the claims asserted against Pharm-Olam by Cytokinetics. 56Table of ContentsOn or around June 7, 2016, the Company, Pharm-Olam, and Datatrak entered into a Settlement Agreement and Mutual Waiver and General Release ofAll Claims in the California Lawsuit, thereby resolving all disputes among the parties. The Settlement Agreement includes no admission of liability orwrongdoing by any party. The Court granted the parties’ joint request for dismissal with prejudice on July 11, 2016. Refer to Note 10, “Commitments andContingencies” in the Notes to the Audited Condensed Consolidated Financial Statements and the settlement agreement in June 2016.Item 4. Mine Safety DisclosuresNot applicable. 57Table of ContentsPART II Item 5.Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity SecuritiesPrior to our initial public offering on April 29, 2004, there was no public market for our common stock. Our common stock was quoted under thesymbol “CYTK” on the NASDAQ Global Market from the date of our initial public offering through December 19, 2012, and has since been quoted on theNASDAQ Capital Market. The following table sets forth the high and low closing sales price per share of our common stock as reported on the NASDAQGlobal Market or NASDAQ Capital Market, as applicable, for the periods indicated. Closing Sale Price High Low 2015: First Quarter $8.17 $6.25 Second Quarter $7.43 $5.51 Third Quarter $7.79 $6.01 Fourth Quarter $12.95 $6.60 2016: First Quarter $10.60 $6.17 Second Quarter $9.49 $7.18 Third Quarter $12.26 $8.55 Fourth Quarter $12.55 $8.83 On February 23, 2017, the last reported sale price for our common stock on the NASDAQ Capital Market was $10.15 per share. We currently expect toretain future earnings, if any, for use in the operation and expansion of our business and have not paid and do not in the foreseeable future anticipate payingany cash dividends. As of February 23, 2017, there were 60 holders of record of our common stock. 58Table of ContentsEquity Compensation InformationInformation regarding our equity compensation plans and the securities authorized for issuance thereunder is set forth in Part III, Item 12.Comparison of Historical Cumulative Total Return Among Cytokinetics, Incorporated, the NASDAQ Stock Market (U.S.) Index and the NASDAQBiotechnology Index (*) (*)The above graph shows the cumulative total stockholder return of an investment of $100 in cash from December 31, 2011 through December 31, 2016for: (i) our common stock; (ii) the NASDAQ Stock Market (U.S.) Index; and (iii) the NASDAQ Biotechnology Index. All values assume reinvestment ofthe full amount of all dividends. Stockholder returns over the indicated period should not be considered indicative of future stockholder returns. 12/31/11 12/31/12 12/31/13 12/31/14 12/31/15 12/31/16 Cytokinetics, Incorporated $100.00 $68.75 $112.85 $139.06 $181.60 $210.94 NASDAQ Composite Index $100.00 $115.91 $160.32 $181.80 $192.21 $206.63 NASDAQ Biotechnology Index $100.00 $131.91 $218.45 $292.93 $326.39 $255.62 The information contained under this caption “Comparison of Historical Cumulative Total Return Among Cytokinetics, Incorporated, the NASDAQStock Market (U.S.) Index and the NASDAQ Biotechnology Index” shall not be deemed to be soliciting material or to be filed with the SEC, nor shall suchinformation be incorporated by reference into any future filing under the Securities Act or the Exchange Act, except to the extent that we specificallyincorporate it by reference into such filing.Sales of Unregistered SecuritiesOn December 26, 2014, we sold 2,040,816 shares of our common stock at a price per share of $4.90 and an aggregate purchase price of $10.0 million toAstellas.We relied on the exemption from registration contained in Section 4(2) of the Securities Act, and Regulation D, Rule 506 thereunder, in connectionwith the issuance and sale of the common stock to Astellas. 59Table of ContentsItem 6. Selected Financial DataThe following selected financial data should be read in conjunction with Item 7, “Management’s Discussion and Analysis of Financial Condition andResults of Operations” and Item 8, “Financial Statements and Supplemental Data” of this report on Form 10-K. Year Ended December 31, 2016 2015 2014 2013 2012 (In thousands, except per share amounts) Statement of Operations Data: Revenues: Research and development revenues from related parties, net (1) $42,994 $14,665 $19,538 $2,019 $4,177 Research and development, grant and other revenues 1,242 75 17,566 7,547 3,382 License revenues from related parties (1) 62,171 13,918 — 17,230 — License revenues — — 9,836 3,852 — Total revenues 106,407 28,658 46,940 30,648 7,559 Operating expenses: Research and development 59,897 46,398 44,426 49,450 35,643 General and administrative 27,823 19,667 17,268 15,092 12,429 Restructuring charges (reversals) — — — — (56) Total operating expenses 87,720 66,065 61,694 64,542 48,016 Operating income (loss) 18,687 (37,407) (14,754) (33,894) (40,457) Interest and other income (expense), net (2,234) (94) 108 177 87 Income (loss) before income taxes 16,453 (37,501) (14,646) (33,717) (40,370) Income tax provision (benefit) — — — — — Net income (loss) 16,453 (37,501) (14,646) (33,717) (40,370) Deemed dividend related to beneficial conversion feature of convertible preferred stock — — — — (1,307) Net income (loss) allocable to common stockholders: $16,453 $(37,501) $(14,646) $(33,717) $(41,677) Net income (loss) per share allocable to common stockholders:(2) Basic $0.41 $(0.97) $(0.41) $(1.24) $(2.30) Diluted $0.39 $(0.97) $(0.41) $(1.24) $(2.30) Weighted average shares used in computing net income (loss) per share allocable to common stockholders:(3) Basic 39,943 38,814 35,709 27,275 18,107 Diluted 42,561 38,814 35,709 27,275 18,107 As of December 31, 2016 2015 2014 2013 2012 (In thousands) Balance Sheet Data: Cash and cash equivalents, and investments $163,921 $111,621 $83,228 $80,230 $74,000 Working capital 125,375 81,458 107,276 52,634 69,322 Total assets 170,142 115,237 132,968 83,188 77,551 Long-term debt 27,381 14,639 — — — Accumulated deficit (518,291) (534,744) (497,243) (482,597) (448,880) Total stockholders’ equity(2) 94,361 68,590 92,064 54,442 70,085 (1)Revenues from related parties consisted of revenues recognized under our research and development arrangements with related parties, includingAmgen and Astellas. See Note 7, “Related Parties and Related Party Transactions” in the Notes to Consolidated Financial Statements for furtherdetails. 60Table of Contents(2)On June 24, 2013, we effected a one-for-six reverse stock split of our common stock through an amendment to our amended and restated certificate ofincorporation (the “COI Amendment”). As of the effective time of the reverse stock split, every six shares of our issued and outstanding commonstock were converted into one issued and outstanding share of common stock, without any change in par value per share. The reverse stock splitaffected all shares of our common stock outstanding immediately prior to the effective time of the reverse stock split, as well as the number of sharesof common stock available for issuance under equity incentive plans. In addition, the reverse stock split effected a reduction in the number of sharesof common stock issuable upon the conversion of shares of preferred stock or upon the exercise of stock options or warrants outstanding immediatelyprior to the effectiveness of the reverse stock split. No fractional shares were issued as a result of the reverse stock split. Stockholders who wouldotherwise have been entitled to receive a fractional share received cash payments in lieu thereof. In addition, the COI Amendment reduced thenumber of authorized shares of common stock to 81.5 million. All references to shares of common stock and per share data for all periods presented in the accompanying selected financial data have been adjustedto reflect the reverse stock split on a retroactive basis. (3)In June 2012, we issued to various investors (i) 9,320,176 shares of common stock for a purchase price of $4.56 per share, (ii) 23,026 shares of SeriesB convertible preferred stock for a purchase price of $760.00 per share, and (iii) warrants to purchase 7,894,704 shares of common stock at an exerciseprice of $5.28 per share, for aggregate gross proceeds of approximately $60.0 million. In 2012, we sold 432,724 shares of common stock throughMLV for net proceeds of $2.8 million. In June 2013, we sold 1,404,100 shares of common stock to Amgen at a price per share of $7.12 and anaggregate purchase price of $10.0 million, pursuant to the Amgen Agreement Amendment. In 2013, we sold 1,170,583 shares of common stockthrough MLV for net proceeds of $7.5 million. In January, 2014 we sold 364,103 shares of common stock through MLV for net proceeds of$2.4 million. In February 2014, we sold 5,031,250 shares of common stock through an underwritten public offering at a price per share of $8.00 andnet proceeds of $37.5 million. In December 2014, we sold 2,040,816 shares of common stock to Astellas at a price per share of $4.90 and an aggregatepurchase price of $10.0 million. The 1,114,168 warrants issued in 2011 to Deerfield, expired unexercised on April 20, 2015. In 2015, we sold 808,193shares of common stock through Cantor pursuant to the CE Offering Sales Agreement for net proceeds of $8.7 million. From January 1, 2017 toFebruary 23, 2017, we sold 185,215 shares of common stock through Cantor pursuant to the CE Offering Sales Agreement for net proceeds of$2,1 million. See Note 11, “Stockholders’ Equity” in the Notes to Consolidated Financial Statements for further details.Item 7. Management’s Discussion and Analysis of Financial Condition and Results of OperationsThis discussion and analysis should be read in conjunction with our financial statements and accompanying notes included elsewhere in this report.Operating results are not necessarily indicative of results that may occur in future periods.OverviewWe were incorporated in Delaware in August 1997 as Cytokinetics, Incorporated. We are a late-stage biopharmaceutical company focused on thediscovery and development of first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromisedand/or declining. Our research and development activities relating to the biology of muscle function have evolved from our knowledge and expertiseregarding the cytoskeleton, a complex biological infrastructure that plays a fundamental role within every human cell. Our most advanced research anddevelopment programs relate to the biology of muscle function and are directed to small molecule modulators of the contractility of skeletal or cardiacmuscle. We are also conducting earlier-stage research directed to other compounds with the potential to modulate muscle contractility and other musclefunctions, such as growth, energetics and metabolism.Our drug candidates currently in clinical development are our fast skeletal troponin activators tirasemtiv and CK-2127107, and our cardiac muscleactivator omecamtiv mecarbil. Tirasemtiv is being evaluated for the 61Table of Contentspotential treatment of amyotrophic lateral sclerosis (“ALS”). CK-2127107 is being evaluated for the potential treatment of spinal muscle atrophy (“SMA”)and chronic obstructive pulmonary disease (“COPD”) and for potential use in other indications associated with muscle weakness (including ALS) under astrategic alliance with Astellas Pharma Inc. (“Astellas”) established in 2013 and expanded in 2014 and 2016. Omecamtiv mecarbil is being evaluated for thepotential treatment of heart failure under a strategic alliance with Amgen established in 2006.Muscle Contractility ProgramsSkeletal Muscle Contractility ProgramTirasemtiv is our lead drug candidate from this program. We retain exclusive rights to tirasemtiv, subject to Astellas’ exercise of its option for a licenseto tirasemtiv (see “Astellas’ Option on Tirasemtiv” below). We conducted a Phase 2 clinical development program for tirasemtiv, and we started a Phase 3clinical development program for this drug candidate in patients with ALS in July 2015 known as VITALITY-ALS (Ventilatory Investigation of Tirasemtivand Assessment of Longitudinal Indices after Treatment for a Year in ALS). Tirasemtiv has been granted orphan drug designation and fast track status by theFDA and orphan medicinal product designation by the European Medicines Agency, in each case for the potential treatment of ALS.In collaboration with Astellas, we are also developing another drug candidate from this program, CK-2127107, for potential indications associatedwith muscle weakness. We started a Phase 2 clinical trial for CK-2127107 in patients with SMA in December 2015. Astellas, in collaboration withCytokinetics, started a Phase 2 clinical trial of CK-2127107 in patients with COPD in June 2016. Tirasemtiv and CK-2127107 are structurally distinct andselective small molecules that activate the fast skeletal troponin complex in the sarcomere by increasing its sensitivity to calcium, leading to an increase inskeletal muscle contractility. Each of tirasemtiv and CK-2127107 has demonstrated pharmacological activity in preclinical models and evidence ofpotentially clinically relevant pharmacodynamic effects in humans. We are evaluating other potential indications for which tirasemtiv and CK-2127107 maybe useful.TirasemtivFurther details regarding tirasemtiv and VITALITY-ALS can be found in Item 1 of this report under “Research and Development Programs — SkeletalMuscle Contractility Program — Tirasemtiv.”The clinical trials program for tirasemtiv may proceed for several years, and we will not be in a position to generate any revenues or material net cashflows from sales of this drug candidate until the program is successfully completed, regulatory approval is achieved, and the drug is commercialized.Tirasemtiv is at too early a stage of development for us to predict if or when this may occur. Our expenditures are expected to increase as we continue toprogress tirasemtiv towards potential registration.CK-2127107 and Other Skeletal Muscle ActivatorsAstellas Strategic Alliance. CK-2127107 is being developed jointly by Cytokinetics and Astellas.In July 2016, we entered into the 2016 Astellas Amendment collectively with the 2014 Astellas Agreement, the “Current Astellas Agreement.”Astellas holds an exclusive license to develop and commercialize CK-2127107 worldwide, subject to our development and commercializationparticipation rights. Under this strategic alliance, Cytokinetics conducted five Phase 1 clinical trials of CK-2127107 and started a Phase 2 clinical trial ofCK-2127107 in patients with spinal muscular atrophy (“SMA”) in December 2015. CK-2127107 is also being evaluated for the potential use in otherindications associated with muscle weakness. Astellas, in collaboration with Cytokinetics, started a Phase 2 62Table of Contentsclinical trial of CK-2127107 in patients with COPD in June 2016 and we anticipate Astellas will initiate a Phase 1b clinical trial of CK-2127107 in elderlypatients with limited mobility in the first half of 2017. We are also conducting joint research with Astellas directed to next-generation skeletal muscleactivators.Further details regarding our strategic alliance with Astellas can be found in Item 1 of this report under “Research and Development Programs —Skeletal Muscle Contractility Program — CK-2127107 and Other Skeletal Muscle Activators — Astellas Strategic Alliance.”During the years ended December 31, 2016, 2015, and 2014, the Company recorded license revenue of $62.2 million, $13.9 million and $9.8 millionrespectively, reimbursement of sponsored research and development activities of $13.1 million, $12.2 million, and $15.4 million, respectively, and milestonerevenues of $2.0 million, zero and $17.0 million, in connection with our strategic alliance with Astellas. Refer to Note 7, “Related Parties and Related PartyTransactions” in the Notes to Consolidated Financial Statements, for the accounting treatment, including the allocation of consideration to the units ofaccounting, and the revenue recognition of License Revenue and Research and Development Revenue, under the 2016 Astellas Amendment.The clinical trials programs for CK-2127107 may proceed for several years, and we will not be in a position to generate any revenues or material netcash flows from sales of this drug candidate until the program is successfully completed, regulatory approval is achieved, and the drug is commercialized.CK-2127107 is at too early a stage of development for us to predict if or when this may occur. Our expenditures will increase if Astellas terminatesdevelopment of CK-2127107 or related compounds and we elect to develop them independently, or if we conduct early-stage development for certain agreedindications at our initial expense, subject to reimbursement if development continues under the collaboration.Ongoing Research in Skeletal Muscle Activators.Our research on the direct activation of skeletal muscle continues in two areas. We are conducting translational research in preclinical models ofdisease and muscle function with fast skeletal troponin activators to explore the potential clinical applications of this novel mechanism in diseases orconditions associated with skeletal muscle dysfunction. We also intend to conduct preclinical research on other chemically and pharmacologically distinctmechanisms to activate the skeletal sarcomere. We advanced a next generation skeletal muscle activator into IND-enabling studies in 2016 and earned a$2.0 million milestone payment. We are conducting a joint research program with Astellas directed to the discovery of next-generation skeletal muscleactivators. Under the 2016 Astellas Amendment, the joint research program will continue through 2017 and Astellas will reimburse us for certain researchactivities.Research and Development Expenses. We recorded research and development expenses for activities relating to our skeletal muscle contractilityprogram of approximately $53.7 million, $36.3 million and $32.9 million in the years ended December 31, 2016, 2015 and 2014, respectively. Werecognized research and development revenue from Astellas of $15.1 million, $12.2 million, and $32.4 million in the years ended December 31, 2016, 2015and 2014, respectively, consisting of milestone payments, and reimbursements of full-time employee equivalents (“FTEs”) and other expenses. We anticipatethat our expenditures relating to the research and development of compounds in our skeletal muscle contractility program will increase significantly if and aswe advance tirasemtiv, CK-2127107 or other compounds from this program into and through development.Cardiac Muscle Contractility ProgramOur lead drug candidate from our cardiac muscle contractility program, omecamtiv mecarbil (formerly known as CK-1827452), is a novel cardiacmuscle myosin activator that is being developed under a strategic alliance with Amgen. In June 2013, we expanded this collaboration to include Japan. As aresult, Amgen holds an exclusive, worldwide license to omecamtiv mecarbil and related compounds, subject to Cytokinetics’ 63Table of Contentsspecified development and commercialization rights. Amgen has also entered an alliance with Servier for exclusive commercialization rights in Europe aswell as the Commonwealth of Independent States (“CIS”), including Russia. In December 2016, we announced the activation of the first trial site for a Phase 3cardiovascular outcomes clinical trial of omecamtiv mecarbil being conducted by Amgen in collaboration with Cytokinetics, GALACTIC-HF (GlobalApproach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure). We are continuing our joint research with Amgendirected to next-generation compounds in our cardiac muscle contractility program in 2017.Further details regarding our strategic alliance with Amgen can be found in Item 1 of this report under “Research and Development Programs —Cardiac Muscle Contractility Program — Amgen Strategic Alliance.”During the years ended December 31, 2016, 2015 and 2014, we recorded $1.2 million, $2.5 million and $4.5 million, respectively, in reimbursement ofsponsored research and development activities, respectively and milestone revenues of $26.7 million, zero and zero, relating to the Amgen Agreement.During the years ended December 31, 2016, 2015 and 2014, we recorded zero license revenue under the Amgen Agreement. See our consolidated financialstatements for a further discussion of our revenue recognition policy under our agreement with Amgen. Refer to Note 7, “Related Parties and Related PartyTransactions” in the Notes to Consolidated Financial Statements, for the accounting treatment, under the Amgen agreement.Omecamtiv Mecarbil Clinical DevelopmentGALACTIC-HF is a Phase 3 cardiovascular outcomes clinical trial of omecamtiv mecarbil which is being conducted by Amgen, in collaboration withCytokinetics. Coincident with the start of the trial, Amgen made a $26.7 million milestone payment to Cytokinetics in December 2016. The primaryobjective of this double-blind, randomized, placebo-controlled multicenter clinical trial is to determine if treatment with omecamtiv mecarbil when added tostandard of care is superior to standard of care plus placebo in reducing the risk of cardiovascular death or heart failure events in patients with high riskchronic heart failure and reduced ejection fraction. GALACTIC-HF will be conducted under a Special Protocol Assessment (“SPA”) with the U.S. FDA.GALACTIC-HF is planned to enroll approximately 8,000 symptomatic chronic heart failure patients in over 800 sites in 34 countries who are either currentlyhospitalized for a primary reason of heart failure or have had a hospitalization or admission to an emergency room for heart failure within one year prior toscreening. In order to be eligible to participate in GALACTIC-HF patients should have an LVEF £ 35%, be NYHA class II to IV, and have an elevated BNP orNT-proBNP. Patients will be randomized to either placebo or omecamtiv mecarbil with dose titration up to a maximum dose of 50 mg twice daily based onthe plasma concentration of omecamtiv mecarbil after initiation of drug therapy. The primary endpoint is a composite of time to cardiovascular death or firstheart failure event, which is defined as either a hospitalization for heart failure or other urgent treatment for worsening heart failure. Secondary endpointsinclude time to cardiovascular death; patient reported outcomes as measured by the Kansas City Cardiomyopathy Questionnaire Total Symptom Score; timeto first heart failure hospitalization; and all-cause death.Cytokinetics and Amgen are also planning a potential exercise performance/cardiac function clinical trial to be conducted by Cytokinetics. Amgenwill be responsible for reimbursing us for the out-of-pocket development costs associated with this clinical trial.Further details regarding the clinical development of omecamtiv mecarbil can be found in Item 1 of this report under “Research and DevelopmentPrograms — Cardiac Muscle Contractility Program — Omecamtiv Mecarbil”Ongoing Research in Cardiac Muscle Contractility. We continued our joint research program with Amgen directed to next-generation compoundsin our cardiac muscle contractility program in 2016. We expect to continue our joint research program with Amgen into 2017. Under the Amgen Agreement,Amgen will reimburse us for certain research activities we perform. 64Table of ContentsThe clinical trials program for omecamtiv mecarbil may proceed for several years, and we will not be in a position to generate any revenues or materialnet cash flows from sales of this drug candidate until the program is successfully completed, regulatory approval is achieved, and the drug is commercialized.Omecamtiv mecarbil is at too early a stage of development for us to predict if or when this may occur. We funded all research and development costsassociated with this program prior to Amgen’s option exercise in May 2009. We anticipate that our expenditures relating to the research and development ofcompounds in our cardiac muscle contractility program will increase if we participate in the future advancement of omecamtiv mecarbil through clinicaldevelopment. Our expenditures will also increase if Amgen terminates development of omecamtiv mecarbil or related compounds and we elect to developthem independently, or if we elect to co-fund later-stage development of omecamtiv mecarbil or other compounds in our cardiac muscle contractility programunder our collaboration and option agreement with Amgen.Research and Development Expenses. We recorded research and development expenses for activities relating to our cardiac muscle contractilityprogram of approximately $8.1 million, $5.8 million and $7.4 million in the years ended December 31, 2016, 2015 and 2014, respectively. We recognizednet research and development revenue from Amgen of $1.2 million, $2.5 million and $4.5 million in the years ended December 31, 2016, 2015 and 2014,respectively, consisting of reimbursements of FTEs and other expenses offset by a payment related to Cytokinetics’ option to co-fund the Phase 3development program of omecamtiv mecarbil for an increased royalty percentage. We anticipate that our expenditures relating to the research anddevelopment of compounds in our cardiac muscle contractility program will increase if we participate in the future advancement of omecamtiv mecarbilthrough clinical development. We also anticipate incurring future payments related to the co-investment option for which we provided notice of exercise in2016 that will be offset against research and development revenues.Beyond Muscle ContractilityWe have developed preclinical expertise in the mechanics of skeletal, cardiac and smooth muscle that extends from proteins to tissues to intact animalmodels. Our translational research in muscle contractility has enabled us to better understand the potential impact of small molecule compounds that increaseskeletal or cardiac muscle contractility and to apply those findings to the further evaluation of our drug candidates in clinical populations. In addition tocontractility, the other major functions of muscle play a role in certain diseases that could benefit from novel mechanism treatments. Accordingly, ourknowledge of muscle contractility may serve as an entry point to the discovery of novel treatments for disorders involving muscle functions other thanmuscle contractility. We are leveraging our current understandings of muscle biology to investigate new ways of modulating these other aspects of musclefunction for other potential therapeutic applications.Development RisksThe successful development of any of our drug candidates is highly uncertain. We cannot estimate with certainty or know the exact nature, timing andcosts of the activities necessary to complete the development of any of our drug candidates or the date of completion of these development activities due tonumerous risks and uncertainties, including, but not limited to: • the results of clinical trials of our drug candidates conducted by us or our partners may not support the further clinical development of those drugcandidates; • further clinical development of tirasemtiv for the potential treatment of ALS will require significant additional funding and we may be unable toobtain such additional funding on acceptable terms, if at all; • the FDA and/or other regulatory authorities may not accept effects on respiratory function, including SVC, as appropriate clinical trial endpoints tosupport the registration of tirasemtiv for the treatment of ALS; 65Table of Contents • the FDA and/or other regulatory authorities may not accept the data from the clinical trials of tirasemtiv as sufficient to determine the safest andmost effective dose of tirasemtiv for the treatment of ALS; • decisions made by Amgen with respect to the development of omecamtiv mecarbil and by Astellas with respect to the development of CK-2127107; • the uncertainty of the timing of the initiation and completion of patient enrollment and treatment in our or our partners’ clinical trials; • the possibility of delays in the collection of clinical trial data and the uncertainty of the timing of the analyses of our clinical trial data after thesetrials have been initiated and completed; • our potential inability to obtain additional funding and resources for our development activities on acceptable terms, if at all, including, but notlimited to, our potential inability to obtain or retain partners to assist in the design, management, conduct and funding of clinical trials; • failure by our clinical trial sites, clinical research organizations, clinical manufacturing organizations and other third parties supporting our or ourpartners’ clinical trials to fulfill their obligations or otherwise perform as expected; • delays or additional costs in manufacturing of our drug candidates for clinical trial use, including developing appropriate formulations of our drugcandidates; • the uncertainty of clinical trial results, including variability in patient response; • the uncertainty of obtaining FDA or other foreign regulatory agency approval required for the clinical investigation of our drug candidates; • the uncertainty related to the development of commercial scale manufacturing processes and qualification of a commercial scale manufacturingfacility; • the possibility that results from non-clinical studies may adversely impact the timing or further development of our drug candidates; and • possible delays in the characterization, formulation and manufacture, packaging, labeling and distribution of drug candidates and other compounds.If we fail to complete the development of any of our drug candidates in a timely manner, it could have a material adverse effect on our operations,financial position and liquidity. In addition, any failure by us or our partners to obtain, or any delay in obtaining, regulatory approvals for our drugcandidates could have a material adverse effect on our results of operations. A further discussion of the risks and uncertainties associated with completing ourprograms as planned, or at all, and certain consequences of failing to do so are discussed further in the risk factors entitled “We will need substantialadditional capital in the future to sufficiently fund our operations,” “We have never generated, and may never generate, revenues from commercial sales ofour drugs and we may not have drugs to market for at least several years, if ever,” “Clinical trials may fail to demonstrate the desired safety and efficacy of ourdrug candidates, which could prevent or significantly delay completion of clinical development and regulatory approval” and “Clinical trials are expensive,time-consuming and subject to delay,” and other risk factors.Financial OverviewRevenuesOur current revenue sources are limited, and we do not expect to generate any revenue from product sales for several years, if at all. We have recognizedrevenues from our strategic alliances with Amgen, Astellas, and MyoKardia, Inc. (“MyoKardia”) and grant revenues from The ALS Association (the “ALSA”). 66Table of ContentsThe following table summarizes the sources of our revenue for the years ended December 31, 2016, 2015 and 2014, respectively, as follows (inthousands): Years Ended December 31, 2016 2015 2014 Astellas License revenues $62,171 $13,918 $9,836 Research and development revenues 15,111 12,184 32,391 Total Revenues from Astellas 77,282 26,102 42,227 Amgen Research and development revenues, net 27,882 2,481 4,538 Total Revenues from Amgen 27,882 2,481 4,538 MyoKardia - Research and development revenues 150 — 100 ALSA - Grant Revenue 1,085 75 — Other Revenue 8 — 75 Total revenues $106,407 $28,658 $46,940 AstellasIn June 2013, we entered into a license and collaboration agreement with Astellas (the “Original Astellas Agreement”), that was amended and restatedin December 2014 (the “2014 Astellas Agreement”).Refer to Item 1, “Business — Skeletal Muscle Contractility Program — CK-2127107 — Astellas Strategic Alliance” for further details regarding thecollaboration agreements.In July 2013, we received an upfront payment of $16.0 million in connection with the execution of the Original Astellas Agreement. The OriginalAstellas Agreement provided for us to potentially receive over $24.0 million in reimbursement of sponsored research and development activities during theinitial two years of the collaboration and for research and early and late stage development milestone payments based on various research and clinicalmilestones. We determined the license and the research and development services relating to the Original Astellas Agreement are a single unit of accountingas the license was determined to not have stand-alone value. Accordingly, we are recognizing this revenue using the proportional performance model. During2014, revenue from reimbursement of research and development activities also included $2.0 million in research and development milestone fees and$15.0 million in milestone fees in connection with the decision made by Astellas to advance CK-2127107 into Phase 2 clinical development.In January 2015, we received an upfront license fee payment of $30.0 million in connection with the execution of the 2014 Astellas Agreement. Also,in conjunction with the execution of the 2014 Astellas Agreement, we entered into a common stock purchase agreement pursuant to which we sold 2,040,816shares of our common stock to Astellas at a price per share of $4.90. The aggregate purchase price of $10.0 million was received in December 2014. Wedetermined the fair value of the stock issued to Astellas to be $9.1 million. The $0.9 million excess of cash received over fair value of was deferred and willbe recognized as revenue as services are performed over approximately 24 months. We determined that the license and the research and development servicesrelating to the 2014 Astellas Agreement are a single unit of accounting as the license was determined to not have stand-alone value. Accordingly, we arerecognizing this revenue using the proportional performance model over the initial research term of the 2014 Astellas Agreement.Concurrently with the execution of the 2014 Astellas Agreement and related common stock purchase agreement, we received $15.0 million as amilestone payment relating to Astellas’ decision to advance CK-2127107 into Phase 2 clinical development. We were also eligible to potentially receiveover $20.0 million in reimbursement of sponsored research and development activities during the two years of the collaboration following the execution ofthe 2014 Astellas Agreement. 67Table of ContentsIn 2016, Cytokinetics and Astellas further amended the collaboration agreement to expand the collaboration to include the development ofCK-2127107 (“2016 Astellas Amendment”) for the potential treatment of ALS, as well as the possible development in ALS of other fast skeletal regulatoryactivators previously licensed by Cytokinetics to Astellas. The 2016 Astellas Amendment became effective in September 2016. In connection with the 2016Astellas Amendment, we received a non-refundable upfront amendment fee of $35.0 million. In addition, we received the accelerated payment of a$15.0 million milestone for the initiation of the first Phase 2 clinical trial of CK-2127107 as the lead compound in ALS that was otherwise provided for in the2014 Astellas Agreement, as if such milestone had been achieved upon the execution of the 2016 Astellas Amendment. We determined that the ALS licenseand the additional research and development services relating to the 2016 Astellas Amendment each have stand-alone value. We have recognized$50.0 million license revenue related to the ALS license on the effective date of the arrangement while the allocated consideration for the research anddevelopment services will be recognized over the development term on a proportional basis. During 2016, revenue from reimbursement of research anddevelopment activities also included $2.0 million in research and development milestone fees.Refer to Note 7, “Related Parties and Related Party Transactions” in the Notes to Consolidated Financial Statements for further details regarding theaccounting treatment under this collaboration agreement.Under the Current Astellas Agreement, additional research and early and late state development milestone payments which are based on variousresearch and clinical milestones, including the initiation of certain clinical studies, the submission for approval of a drug candidate to certain regulatoryauthorities for marketing approval and the commercial launch of collaboration products could total over $600.0 million, including up to $95.0 millionrelating to CK-2127107 in non-neuromuscular indications, and over $100.0 million related to CK-2127107 in each of SMA and other neuromuscularindications. Additionally, $200.0 million in commercial milestones could be received under the Current Astellas Agreement provided certain sales targets aremet. Due to the nature of drug development, including the inherent risk of development and approval of drug candidates by regulatory authorities, it is notpossible to estimate if and when these milestone payments could become due.In the event Astellas commercializes any collaboration products, the Company will receive royalties on sales of such collaboration products, includingroyalties ranging from the high single digits to the high teens on sales of products containing CK-2127107. We can co-fund certain development costs forCK-2127107 and other compounds in exchange for increased milestone payments and royalties; such royalties may increase under certain scenarios toexceed twenty percent. Under the Current Astellas Agreement, we retain an option to co-promote collaboration products containing fast skeletal troponinactivators for neuromuscular indications in the U.S., Canada and Europe, in addition to its option to co-promote other collaboration products in the U.S. andCanada as provided for in the Original Astellas Agreement. Astellas will reimburse us for certain expenses associated with its co-promotion activities.In connection with the execution of the 2016 Astellas Amendment, the Company received a $15.0 million non-refundable option fee for the grant ofthe Option on Tirasemtiv in October 2016. Prior to Astellas’ exercise of the option, the Company will continue the development of tirasemtiv, including theVITALITY-ALS trial, at its own expense to support regulatory approval in the U.S., EU and certain other jurisdictions and will retain the final decisionmaking authority on the development of tirasemtiv.AmgenIn June 2013, we and Amgen executed an amendment (the “Amgen Agreement Amendment”) to the Amgen Agreement to include Japan, resulting in aworldwide collaboration.Further details regarding our strategic alliance with Amgen can be found in Item 1 of this report under “Research and Development Programs —Cardiac Muscle Contractility Program — Amgen Strategic Alliance.” 68Table of ContentsWe have received reimbursements from Amgen for certain research and development activities during 2016, 2015 and 2014, which we recorded asrevenue as the related expenses were incurred. We may be eligible to receive further reimbursements from Amgen for certain research and developmentactivities, which we will record as revenue if and when the related expenses are incurred. We record amounts received in advance of performance as deferredrevenue. Revenues related to the reimbursement of FTEs were based on negotiated rates intended to approximate the costs for our FTEs.Refer to Note 7, “Related Parties and Related Party Transactions” in the Notes to Consolidated Financial Statements for further details regarding theaccounting treatment under this collaboration agreement.Under the Amgen Agreement, as amended, the Company is eligible to receive over $300.0 million in additional development milestone paymentswhich are based on various clinical milestones, including the initiation of certain clinical studies, the submission of a drug candidate to certain regulatoryauthorities for marketing approval and the receipt of such approvals. Additionally, the Company is eligible to receive up to $300.0 million in commercialmilestone payments provided certain sales targets are met. Due to the nature of drug development, including the inherent risk of development and approvalof drug candidates by regulatory authorities, it is not possible to estimate if and when these milestone payments would become due. The achievement of eachof these milestones is dependent solely upon the results of Amgen’s development and commercialization activities and therefore none of these milestoneswas deemed to be substantive.In December 2016, we received a $26.7 million milestone payment from Amgen coincident with the start of GALACTIC-HF. The $26.7 millionmilestone payment from Amgen was recognized as revenue for the year ended December 31, 2016. We recognized no revenue for milestones achieved underthe Amgen Agreement during the years ended December 31, 2015 and 2014. Also in December 2016, we provided notice of our exercise of our option toco-invest in the Phase 3 development program of omecamtiv mecarbil in exchange for increased royalties from Amgen on worldwide sales of omecamtivmecarbil outside Japan.MyoKardiaIn August 2012, we entered into a collaboration agreement with MyoKardia. Under an agreed research plan, scientists from MyoKardia and our FTEsconducted research focused on small molecule therapeutics that inhibit cardiac sarcomere proteins. We provided MyoKardia access to certain researchfacilities, and provided FTEs and other resources at agreed reimbursement rates that approximated our costs. We were the primary obligor in the collaborationarrangement, and accordingly, we recorded expense reimbursements from MyoKardia as research and development revenue. The research plan ended asplanned in August 2013. In October 2016, we received a $0.2 million milestone payment from MyoKardia for the initiation of first Phase IIa clinical trial.ALSA GrantIn July 2015, we were awarded a $1.5 million grant from The ALS Association (the “ALSA Grant”) to support the conduct of VITALITY-ALS as well asthe collection of clinical data and plasma samples from patients in VITALITY-ALS in order to help advance the discovery of potentially useful biomarkers inALS. The grant provides funding for collaboration among Cytokinetics, The ALS Association and the Barrow Neurological Institute to enable plasmasamples collected from patients enrolled in VITALITY-ALS to be added to The Northeastern ALS Consortium (NEALS) Repository, a resource for theacademic research community to identify biomarkers that may help to assess disease progression and underlying disease mechanisms in ALS. In August2015, we achieved the first milestone under the ALSA Grant which triggered a payment of $0.5 million in accordance with the ALSA Grant and in 2016, weachieved a second milestone which triggered a payment of $0.3 million in accordance with the ALSA Grant. We recorded grant revenue as qualified expenseswere incurred and approved by management.Because a substantial portion of our revenues for the foreseeable future will depend on achieving development and other pre-commercializationmilestones under our strategic alliances with Amgen and Astellas, our results of operations may vary substantially from year to year. 69Table of ContentsIf one or more of our drug candidates is approved for sale as a drug, we expect that our future revenues will most likely be derived from royalties onsales from drugs licensed to Amgen and Astellas under our respective strategic alliances and from those licensed to future partners, and from direct sales ofour drugs.Research and DevelopmentWe incur research and development expenses associated with both partnered and our own research activities. We expect to incur research anddevelopment expenses for the clinical development of tirasemtiv. We expect to incur research and development expenses for CK-2127107 in accordancewith agreed upon research and development plans with Astellas. We expect to incur research and development expenses for omecamtiv mecarbil and othernext-generation compounds in our cardiac muscle contractility program in accordance with agreed upon research and development plans with Amgen.Research and development expenses related to any development and commercialization activities we elect to fund consist primarily of employeecompensation, supplies and materials, costs for consultants and contract research and manufacturing, facilities costs and depreciation of equipment.General and Administrative ExpensesGeneral and administrative expenses consist primarily of compensation for employees in executive and administrative functions, including, but notlimited to, finance, human resources, legal, business and commercial development and strategic planning. Other significant costs include facilities costs,consulting costs and professional fees for accounting and legal services, including legal services associated with obtaining and maintaining patents andregulatory compliance.Stock CompensationThe following table summarizes stock-based compensation related to stock options, restricted stock awards, restricted stock units, and employee stockpurchases for 2016, 2015 and 2014 (in thousands): Years Ended December 31, 2016 2015 2014 Research and development $4,252 $1,828 $1,361 General and administrative 2,894 2,739 1,969 Stock-based compensation included in operating expenses $7,146 $4,567 $3,330 As of December 31, 2016, there was $8.4 million of unrecognized compensation cost related to unvested stock options, which is expected to berecognized over a weighted-average period of 2.4 years and $3.1 million of unrecognized compensation cost related to unvested restricted stock units,including the performance stock units (PSU’s), which is expected to be recognized over a weighted-average period of 1.2 years. 70Table of ContentsResults of OperationsYears ended December 31, 2016, 2015 and 2014Revenues Years Ended December 31, Increase(Decrease) 2016 2015 2014 2016 2015 (In millions) Research and development revenues from related parties, net $43.0 $14.7 $19.5 $28.3 $(4.8) Research and development, grant and other revenues 1.2 0.1 17.6 1.1 (17.5) License revenues from related parties 62.2 13.9 — 48.3 13.9 License revenues — — 9.8 — (9.8) Total revenues $106.4 $28.7 $46.9 $77.7 $(18.2) Research and development revenues from related parties refers to research and development revenues from our strategic alliances with Astellas andAmgen. Revenues from Astellas, which became a related party in December 2014, were $15.1 million, $12.2 million, and $15.0 million for years endedDecember 31, 2016, 2015 and 2014, respectively, and consisted of reimbursements of internal costs for certain full-time employee equivalents, and otherresearch and development expenses. Revenues from Astellas in 2016 and 2014 included $2.0 million and $15.0 million in milestone revenues, respectively.All research and development revenues from Astellas, prior to it becoming a related party are classified in research and development, grant and otherrevenues. Revenues from Amgen were $27.9 million, $2.5 million and $4.5 million in 2016, 2015 and 2014, respectively. Revenue from Amgen in 2016included $26.7 million in a milestone payment, and $0.6 million in reimbursement of internal costs for certain full-time employee equivalents, partiallyoffset by a payment of $1.3 million related to the option to co-fund Phase 3 development of omecamtiv mecarbil for an increased royalty percentage.Revenue from Amgen in 2015 and 2014 consisted of reimbursement of internal costs for certain full-time employee equivalents, and recognition of allocatedconsideration relating to the Amgen Agreement Amendment.Research and development, grant and other revenues in 2016 and 2015 consisted primarily of $1.1 million and $0.1 million of research anddevelopment revenues from our collaboration with ALSA, respectively. Research and development, grant and other revenues in 2014 consisted primarily ofrevenues from our strategic alliance with Astellas, prior to becoming a related party in December 2014, including $15.4 million of research and developmentreimbursement revenues and $2.0 million in milestone revenues from our collaboration with Astellas, as well as $0.1 million in revenue from ourcollaboration with MyoKardia.License revenues from related parties refers to license revenues from our strategic alliances with Astellas and Amgen. License revenues from Astellas,which became a related party in December 2014, were $62.2 million and $13.9 million in 2016 and 2015, respectively. License revenue from Astellas in2016 consisted of the recognition of the $50.0 million upfront license fee received from Astellas under the 2016 Astellas Amendment, and the recognition ofa portion of the $30.0 million upfront license fee received from Astellas in January 2015. License revenue from Astellas in 2015 consisted of the recognitionof a portion of the $30.0 million upfront license fee received from Astellas in January 2015 and the recognition of a portion of the $16.0 million upfrontlicense fee received from Astellas in July 2013. The upfront license fees were recognized using the proportional performance model.License revenues refers to license revenues from our collaboration with Astellas, prior to it becoming a related party in December 2014. Licenserevenues from Astellas included $9.8 million in 2014 of the $16.0 million upfront license fee received from Astellas in July 2013 in connection with theexecution of the Original Astellas Agreement. We recognized this revenue over the term of the research and development services using the proportionalperformance model. 71Table of ContentsResearch and development expenses Years Ended December 31, Increase(Decrease) 2016 2015 2014 2016 2015 (In millions) Research and development expenses $59.9 $46.4 $44.4 $13.5 $2.0 The increase in research and development expenses in 2016 compared to 2015 was primarily due to an increase of $12.1 million in outsourced clinicalcosts, $4.5 million in personnel related expenses and non-cash stock compensation expense, and $0.8 million in outsourced research costs, partially offset bya decrease of $4.2 million in outsourced preclinical costs mainly associated with clinical manufacturing activities. The increase in outsourced clinical costswas comprised of an increase of $16.6 million in outsourced clinical costs mainly associated with VITALITY-ALS, offset by a $4.5 million litigationsettlement in June 2016 from a contract research organization for BENEFIT-ALS. The increase in research and development expenses in 2015 compared to2014 was primarily due to an increase of $2.0 million in outsourced preclinical costs, an increase of $1.8 million in personnel related expenses due toincreased headcount, and an increase of $0.4 million in lab expenses, partially offset by a decrease of $2.1 million in outsourced clinical costs associatedwith the completion of BENEFIT-ALS in the second quarter of 2014.The following presents our research and development expenses by program: Years Ended December 31, Increase(Decrease) 2016 2015 2014 2016 2015 (In millions) Cardiac muscle contractility $8.1 $5.8 $7.4 $2.3 $(1.6) Skeletal muscle contractility 49.2 36.3 32.9 12.9 3.4 Smooth muscle contractility — 0.2 — (0.2) 0.2 All other research programs 2.6 4.1 4.1 (1.5) — Total research and development expenses $59.9 $46.4 $44.4 $13.5 $2.0 From a program perspective, the $13.5 million increase in research and development spending in 2016 compared to 2015 was primarily due toincreased spending of $12.9 million for our skeletal muscle contractility program, which included our skeletal muscle contractility program for tirasemtiv forthe treatment of ALS and the clinical program for CK-2127107 under our collaboration with Astellas, and a $2.3 million increase in our cardiac musclecontractility program under our collaboration with Amgen, partially offset by decreased spending of $1.5 million in our other research and preclinicalprograms. The $2.0 million increase in research and development spending in 2015 compared to 2014 was primarily due to increased spending of$3.4 million for our skeletal muscle contractility program, which included our skeletal muscle contractility program for tirasemtiv for the treatment of ALS,and the clinical program for CK-2127107 under our collaboration with Astellas, and a $0.2 million increase in our other research and preclinical programs,partially offset by decreased spending of $1.6 million for our cardiac muscle contractility program under our collaboration with Amgen.Clinical development timelines, the likelihood of success and total completion costs vary significantly for each drug candidate and are difficult toestimate. We anticipate that we will determine on an ongoing basis which research and development programs to pursue and how much funding to direct toeach program, taking into account the scientific and clinical success of each drug candidate. The lengthy process of seeking regulatory approvals andsubsequent compliance with applicable regulations requires the expenditure of substantial resources. Any failure by us to obtain and maintain, or any delayin obtaining, regulatory approvals could cause our research and development expenditures to increase and, in turn, could have a material adverse effect onour results of operations. 72Table of ContentsWe expect our research and development expenditures to increase significantly in 2017 compared to 2016. We expect to continue the Phase 3 clinicaldevelopment of our drug candidate tirasemtiv for the potential treatment of ALS. Under our strategic alliance with Astellas, we expect to continuedevelopment of our drug candidate CK-2127107 for the potential treatment of SMA and potentially other diseases and medical conditions associated withmuscle weakness or wasting. Under our strategic alliance with Amgen, we expect to continue the Phase 3 development of our drug candidate omecamtivmecarbil for the potential treatment of heart failure.General and administrative expenses Years Ended December 31, Increase(Decrease) 2016 2015 2014 2016 2015 (In millions) General and administrative expenses $27.8 $19.7 $17.3 $8.1 $2.4 General and administrative expenses increased $8.1 million in 2016 compared to 2015 was primarily due to increased spending of $4.2 million inpersonnel-related expenses due to increased headcount and non-cash stock compensation expense, an increase of $1.7 million in corporate and patent legalfees, and an increase of $1.7 million in outsourced costs related to commercial development, grants and sponsorships, and accounting and finance andrecruitment related costs. The increase of $2.4 million in 2015 compared to 2014 was primarily due to increased spending of $1.4 million for personnel-related costs due to increased headcount and increased spending of $0.8 million for outside services mainly related to commercial development. We expectthat general and administrative expenses in 2017 will increase significantly compared to 2016, mainly due to increased headcount.Interest expenseInterest expense for the years ended December 31, 2016 and 2015 primarily consisted of interest expense related to the loan and security agreementwith Oxford Finance LLC and Silicon Valley Bank entered into in October 2015. Interest expense increased in 2016 compared to 2015 due to interestexpense related to the long-term debt obligations which commenced in fourth quarter 2015.Interest and Other Income, netInterest and other income, net for the years ended December 31, 2016, 2015 and 2014, primarily consisted of interest income generated from theCompany’s cash, cash equivalents and investments. In 2016 and 2015, interest income also included net gains realized upon disposal of equipment. 73Table of ContentsLiquidity and Capital ResourcesOur financial condition is summarized as follows: As of December 31, Increase(Decrease) 2016 2015 2016 Financial assets: Cash and cash equivalents $66.9 $65.1 $1.8 Short-term investments 89.4 46.4 43.0 Long-term investments 7.6 0.2 7.4 Total cash, cash equivalents and marketable securities $163.9 $111.7 $52.2 Borrowings: Current portions of long-term debt $2.5 $— $2.5 Long-term debt 27.4 14.6 12.8 Total borrowings $29.9 $14.6 $15.3 Working capital: Current assets $158.6 $113.1 $45.5 Current liabilities (33.3) (31.6) (1.7) Total working capital $125.3 $81.5 $43.8 From August 5, 1997, our date of inception, through December 31, 2016, we funded our operations through the sale of equity securities, non-equitypayments from collaborators, long term debt, capital equipment financings, grants and interest income. Due to our substantial research and developmentexpenditures, we have generated significant operating losses since our inception. Our expenditures are primarily related to research and developmentactivities. As of December 31, 2016, we had available cash, cash equivalents and investments of $163.9 million.Equity SecuritiesWe have received net proceeds from the sale of equity securities of $500.0 million from August 5, 1997, the date of our inception, throughDecember 31, 2016, excluding sales of equity to Amgen, Astellas, and GlaxoSmithKline (“GSK”). Included in these proceeds are $94.0 million received uponclosing of the initial public offering of our common stock in May 2004. In connection with execution of our collaboration and license agreement with GSKin 2001, GSK made a $14.0 million equity investment in us. GSK made additional equity investments in us in 2003 and 2004 of $3.0 million and$7.0 million, respectively. In January 2007, in connection with the execution of the Amgen Agreement, we received net proceeds of $32.9 million from astock purchase agreement with Amgen. In June 2013, in conjunction with the Amgen Agreement Amendment, we sold 1,404,100 shares of common stock toAmgen for an aggregate purchase price of $10.0 million. In December 2014, in connection with the 2014 Astellas Agreement, we sold 2,040,816 shares ofcommon stock to Astellas for an aggregate purchase price of $10.0 million.Collaboration PartnersOn a cumulative basis through December 31, 2016, we have received $160.7 million in non-equity payments from Amgen, $169.1 million innon-equity payments from Astellas, and $54.5 million in non-equity payments from GSK, in each case related to our strategic alliances.Original Astellas AgreementIn June 2013, we entered into the Original Astellas Agreement (see Note 7, “Related Party Research and Development Arrangements” in the Notes toConsolidated Financial Statements). In July 2013, we received an 74Table of Contentsupfront non-refundable license payment of $16.0 million in connection with the execution of the Original Astellas Agreement. Pursuant to that agreement wewere eligible to potentially receive over $24.0 million in reimbursement of sponsored research and development activities during the initial two years of thecollaboration. In addition, the agreement also provided for payments for the achievement of pre-specified milestones relating to the joint research anddevelopment program.2014 Astellas AgreementIn December 2014, we entered into the 2014 Astellas Agreement, which superseded the Original Astellas Agreement (see Note 7, “Related PartyResearch and Development Arrangements” in the Notes to Consolidated Financial Statements). Under the terms of the 2014 Astellas Agreement, we receiveda non-refundable upfront license fee of $30.0 million in January 2015. In conjunction with the 2014 Astellas Agreement, we also entered into a commonstock purchase agreement pursuant to which we sold 2,040,816 shares common stock to Astellas at a price per share of $4.90. The aggregate purchase price of$10.0 million was received in December 2014. We determined the fair value of the stock issued to Astellas to be $9.1 million. The excess of cash receivedover fair value of $0.9 million was deferred and will be recognized as revenue as services are performed over approximately 24 months.We were eligible to potentially receive over $20.0 million in reimbursement of sponsored research and development activities during the two years ofthe collaboration following execution of the 2014 Astellas Agreement.2016 Astellas Amendment (Inclusion of ALS as an Added Indication and Option on Tirasemtiv)The 2016 Amendment to the 2014 Astellas Agreement (“2016 Astellas Amendment”) became effective in September 2016 (collectively with the 2014Astellas Agreement, the “Current Astellas Agreement”). Under the 2016 Astellas Amendment, we granted Astellas an option to enter into a pre-negotiatedagreement for a global collaboration for the development and commercialization of tirasemtiv. If Astellas exercises the option, Astellas will receive exclusiveworldwide commercialization rights for Astellas outside Cytokinetics’ commercialization territory in North America, Europe and other select countries. Inaddition, the 2016 Astellas Amendment expands our collaboration with Astellas to include the development of CK-2127107 for the potential treatment ofALS, as well as other fast skeletal regulatory activators licensed to Astellas under the 2014 Astellas Agreement. Finally, the 2016 Astellas Amendmentextends the existing joint research program focused on the discovery of additional next-generation skeletal muscle activators through 2017, includingsponsored research at Cytokinetics.In connection with the execution of the 2016 Astellas Amendment, we received a $15.0 million non-refundable option fee for the grant of the Optionon Tirasemtiv. Prior to Astellas’ exercise of the option, we will continue the development of tirasemtiv, including VITALITY-ALS, at our own expense tosupport regulatory approval in the U.S., EU and certain other jurisdictions and will retain the final decision making authority on the development oftirasemtiv. If Astellas exercises the option, we will grant Astellas an exclusive license to develop and commercialize tirasemtiv outside Cytokinetics’ owncommercialization territory of North America, Europe and other select countries. Each party would be primarily responsible for the further development oftirasemtiv in its territory and have the exclusive right to commercialize tirasemtiv in its territory.Also in connection with the execution of the 2016 Astellas Amendment, we received a non-refundable upfront amendment fee of $35.0 million. Wealso received the accelerated payment of a $15.0 million milestone payment for the initiation of the first Phase 2 clinical trial of CK-2127107 as the leadcompound in ALS that was otherwise provided for in the 2014 Astellas Agreement, as if such milestone had been achieved upon the execution of the 2016Astellas Amendment. The parties will share equally the costs of developing CK-2127107 in ALS for the potential registration and marketing authorization inthe U.S. and Europe, provided that (i) Astellas has agreed to solely fund Phase 2 development costs of CK-2127107 in ALS, subject to a right to recoupCytokinetics’ share of such costs plus a 100% premium by reducing future milestone and royalty 75Table of Contentspayments to Cytokinetics, and (ii) Cytokinetics may defer (but not eliminate) a portion of its co-funding obligation for development activities after Phase 2for up to 18 months, subject to certain conditions. Cytokinetics has the right to co-fund its share of such Phase 2 development costs on a current basis, inwhich case there would not be a premium due to Astellas. We are also eligible to receive up to approximately $41.8 million in additional sponsored researchand development funding through 2018 which includes Astellas’ funding of Cytokinetics’ conduct of the Phase 2 clinical development of CK-2127107 inALS (approximately $36.6 million) as well as the continuing research collaboration (approximately $5.2 million). In 2016, 2015, and 2014, we recognizedrevenue of $77.3 million, 26.1 million, and $42.2 million, respectively relating to the Current Astellas Agreement.Under the Current Astellas Agreement, based on the achievement of pre-specified criteria, Cytokinetics may receive over $600.0 million in milestonepayments relating to the development and commercial launch of collaboration products, including up to $95.0 million relating to CK-2127107 innon-neuromuscular indications, and over $100.0 million in development and commercial launch milestones for CK-2127107 in each of SMA, ALS and otherneuromuscular indications. Cytokinetics may also receive up to $200.0 million in payments for achievement of pre-specified sales milestones related to netsales of all collaboration products under the Current Astellas Agreement. If Astellas commercializes any collaboration products, Cytokinetics will alsoreceive royalties on sales of such collaboration products, including royalties ranging from the high single digits to the high teens on sales of productscontaining CK-2127107. Cytokinetics can co-fund certain development costs for CK-2127107 and other compounds in exchange for increased milestonepayments and royalties; such royalties may increase under certain scenarios to exceed twenty percent. In addition to the foregoing development, commerciallaunch and sales milestones, Cytokinetics may also receive payments for the achievement of pre-specified milestones relating to the joint research program.If Astellas exercises its option for a global collaboration for the development and commercialization of tirasemtiv, Cytokinetics will receive an optionexercise payment ranging from $25.0 million (if exercise occurs following receipt of data from the VITALITY-ALS trial) to $80.0 million (if exercise occursfollowing receipt of FDA approval) and a milestone payment of $30.0 million from Astellas associated with Cytokinetics’ initiation of the open-labelextension trial for tirasemtiv (VIGOR-ALS). Cytokinetics will be responsible for the development costs of tirasemtiv during the option period, but if Astellas’exercises the option after the defined review period following receipt of data from VITALITY-ALS, Astellas will at the time of option exercise reimburseCytokinetics for a share of any additional costs incurred after such review period.If Astellas exercises the option for tirasemtiv, the parties will share the future development costs of tirasemtiv in North America, Europe and certainother countries (with Cytokinetics bearing 75% of such shared costs and Astellas bearing 25% of such costs), and Astellas will be solely responsible for thedevelopment costs of tirasemtiv specific to its commercialization territory. Contingent upon the successful development of tirasemtiv, we may receivemilestone payments up to $100.0 million for the initial indication and up to $50.0 million for each subsequent indication. If tirasemtiv is commercialized,Astellas will pay us royalties (at rates ranging from the mid-teens to twenty percent) on sales of tirasemtiv in Astellas’ territory, and we will pay Astellasroyalties (at rates up to the mid-teens) on sales of tirasemtiv in our commercialization territory, in each case subject to various possible adjustments.Amgen Agreement AmendmentIn June 2013, we entered into the Amgen Agreement Amendment, which expanded our strategic alliance to include Japan (see Note 7, “Related PartyResearch and Development Arrangements” in the Notes to Consolidated Financial Statements). Under the terms of the Amgen Agreement Amendment, wereceived a non-refundable upfront license fee of $15 million in June 2013. In conjunction with the Amgen Agreement Amendment, we also entered into acommon stock purchase agreement pursuant to which we sold 1,404,100 shares common stock to Amgen at a price per share of $7.12. The aggregate purchaseprice of $10.0 million was received in June 2013. We determined the fair value of the stock issued to Amgen to be $7.5 million. The excess 76Table of Contentsof cash received over fair value of $2.5 million was deferred and was recognized as revenue as services were performed over approximately 12 months.Under the Amgen Agreement as amended, we are eligible for potential additional pre-commercialization and commercialization milestone payments ofover $600.0 million in the aggregate on omecamtiv mecarbil and other potential products arising from research under the collaboration, and royalties thatescalate based on increasing levels of annual net sales of products commercialized under the agreement. In December 2016, we provided notice of our initialexercise of our option to co-invest at the $10.0 million level in the Phase 3 development program of omecamtiv mecarbil in exchange for an incrementalroyalty from Amgen of up to 1% on increasing worldwide sales of omecamtiv mecarbil outside Japan. In February 2017, we agreed to increase our co-fundingto $40 million, which will make us eligible to receive an incremental royalty of up to 4% on increasing worldwide sales of omecamtiv mecarbil outside ofJapan and afford us the right to co-promote omecamtiv mecarbil in institutional care settings in North America, with reimbursement by Amgen for certainsales force activities.Royalty Purchase AgreementIn February 2017, we entered into a Royalty Purchase Agreement (“Royalty Agreement”) with RPI Finance Trust (“RPI”), an entity related to RoyaltyPharma. Under the Royalty Agreement, we sold a portion of our right to receive royalties on future net sales of omecamtiv mecarbil (and potentially othercompounds with the same mechanism of action) under the Amgen Agreement (as amended) to RPI for a payment of $90.0 million and an investment in ourcommon stock of $10.0 million pursuant to a concurrently executed Common Stock Purchase Agreement with RPI. See Note 15 – “Subsequent Events” in theNotes to Consolidated Financial Statements for additional information.February 2014 Public OfferingOn February 25, 2014, we closed an underwritten public offering for the issuance and sale of 5,031,250 shares of our common stock. The grossproceeds from this public offering were $40.3 million and net proceeds were $37.5 million, after deducting the underwriting discount and offering expenses.Cantor FitzgeraldOn September 4, 2015, we entered into a $40.0 million Controlled Equity Offering Sales Agreement (“CE Offering”) with Cantor Fitzgerald & Co.,pursuant to which we issue and sold, through December 31, 2016, 808,193 shares for total net proceeds of approximately $8.7 million. Through February 23,2017, we issued and sold 993,408 shares for total net proceeds of approximately $11.0 million and $28.7 million remains available to us under the September2015 Registration Statement.Warrants issued in June 2012 Public OfferingsOn June 20, 2012, we entered into underwriting agreements for two separate, concurrent offerings of our securities (the “June 2012 Public Offerings”).The warrants issued in the June 2012 Public Offerings became exercisable upon issuance and will remain exercisable until June 25, 2017. In August 2016,warrants to purchase 104,533 shares of our common stock at an exercise price of $5.28 per share were exercised in accordance with the June 2012 PublicOfferings underwriting agreements. In September 2016, we issued 690,580 shares of common stock related to cashless exercise of warrants. As ofDecember 31, 2016, warrants to purchase 4,104,966 shares of our common stock were outstanding and exercisable.October 2015 Loan AgreementOn October 19, 2015 and February 10, 2016, we entered into a loan and security agreement (the “Loan Agreement”) with Oxford Finance LLC(“Oxford,”) as the collateral agent and a lender, and Silicon Valley Bank 77Table of Contents(“SVB,”) as a lender (Oxford and SVB collectively the “Lenders”) to fund our working capital and other general corporate needs, for Term A and Term B,respectively. We can, in our sole discretion, draw down an additional $10.0 million under the Loan Agreement from the Lenders, at any time prior toMarch 31, 2017, subject to Cytokinetics’ satisfaction of specified conditions precedent related to the earlier of (i) the occurrence of an equity even asdescribed in the Loan Agreement, or (ii) specified results from VITALITY-ALS, the Company’s Phase 3 trial of tirasemtiv, each as specified in the LoanAgreement. As of December 31, 2016 we received $29.9 million from these loan and security agreements for Term A and Term B, net of issuance cost. Note 9,“Long-Term Debt” of the Notes to Consolidated Financial Statements for further details.Sources and Uses of CashOur cash, cash equivalents and investments totaled $163.9 million at December 31, 2016, compared to $111.6 million at December 31, 2015. Theincrease of $52.3 million was primarily due to the receipt of $65.0 million from Astellas in October 2016, receipt of a $26.7 million milestone payment fromAmgen in December 2016, and net proceeds received from the Loan Agreement of $14.9 million and other net cash provided by operations.Net cash provided by operating activities was $37.0 million in the year ended December 31, 2016 and was largely due to the receipt of $65.0 millionfrom Astellas in October 2016, the receipt of a $26.7 million milestone payment from Amgen in December 2016, partially offset by cash used by operationsdue to the ongoing research and development activities, and general and administrative spend to support those activities. Net income for the year endedDecember 31, 2016 included non-cash stock based compensation of $7.1 million. At December 31, 2016, deferred revenue of $23.1 million related primarilyto the deferral of revenue for Astellas’ Option on Tirasemtiv.Net cash provided by operating activities was $4.9 million in the year ended December 31, 2015 and was largely due to the receipt of $45.0 millionfrom Astellas in January 2015, partially offset by cash used by operations due to the ongoing research and development activities. The net loss for the yearended December 31, 2015 included non-cash stock based compensation of $4.6 million. At December 31, 2015, deferred revenue of $20.9 million relatedprimarily to the deferral of revenue for Astellas based on the proportional performance model.Net cash used in operating activities was $44.8 million in the year ended December 31, 2014 and was largely due to the ongoing research anddevelopment activities and recognition of deferred revenue for which payment had been received in prior periods. The net loss for the year endedDecember 31, 2014 included non-cash stock based compensation of $3.3 million. At December 31, 2014, deferred revenue of $33.6 million related largely tothe deferral of revenue for Astellas based on the proportional performance model.Net cash used in investing activities of $52.1 million in the year ended December 31, 2016 was primarily due to purchases of investments of$145.2 million and purchases of property and equipment of $1.6 million, partially offset by cash proceeds from the maturities of investments of$94.6 million. Net cash provided by investing activities of $16.1 million in the year ended December 31, 2015 was primarily due to proceeds from thematurity of investments of $132.2 million which exceeded purchases of investments by $16.6 million, partially offset by cash used by investing activities forpurchases of property and equipment. Net cash used in investing activities of $4.0 million in the year ended December 31, 2014 was primarily due topurchases of investments, which exceeded proceeds from the maturity of investments by $2.9 million, and purchases of property and equipment.Net cash provided by financing activities was $16.9 million in the year ended December 31, 2016 was primarily due to net proceeds from the LoanAgreement of $14.9 million, proceeds from common stock purchases under our Employee Stock Purchase Plan of $0.9 million, proceeds from common stockissuances from warrant exercises of $0.6 million, and net proceeds from issuances of restricted stock to employees and 78Table of Contentsemployee stock option exercises of $0.4 million. Net cash provided by financing activities was $23.9 million in the year ended December 31, 2015 wasprimarily due to net proceeds from the Loan Agreement of $14.9 million, net proceeds pursuant to the CE Offering of $8.7 million, and net proceeds fromissuances of restricted stock to employees and employee stock option exercises of $0.4 million. Net cash provided by financing activities was $48.9 millionin the year ended December 31, 2014 and primarily consisted of net proceeds of $37.5 million from the February 2014 public offering, net proceeds of$2.4 million from sales of our common stock pursuant to the MLV Agreement and proceeds of $9.1 million from the sale of common stock to Astellas.Shelf Registration StatementsIn November 2013, we filed a shelf registration statement with the SEC, which was declared effective in December 2013 (the “December 2013 Shelf”).The December 2013 Shelf allowed us to issue common stock and preferred stock, and/or warrants to purchase any of such securities with a total value of up to$150.0 million. This shelf expired when the January 2017 Shelf became effective.In September 2015, we filed a registration statement on Form S-3 with the SEC, which was declared effective in September 2015 (the “September 2015Registration Statement”) in conjunction with the CE Offering with Cantor Fitzgerald & Co. Pursuant to the terms of the CE Offering we may offer and sell,from time to time through Cantor Fitzgerald, shares of our common stock, having an aggregate offering price of up to $40.0 million. As of December 31,2016, 808,193 shares of common stock were sold pursuant the CE Offering for total net proceeds of approximately $8.7 million. As of February 23, 2017,$28.7 million remains available to us under the September 2015 Registration Statement.In December 2016, we filed a registration statement on Form S-3 with the SEC, which was declared effective in January 2017 (the “January 2017Shelf”). The January 2017 Shelf registered up to $200.0 million of our common stock and preferred stock, and/or warrants to purchase any of such securities.The specific terms any offering pursuant to under the January 2017 Shelf will be established at the time of such offering.Contractual Obligations and CommitmentsOur contractual obligations for the next five years and thereafter are as follows (in thousands): Payments Due by Period 2017 2018-2019 2020-2021 Beyond Total Long-term debt(1) $2,500 $20,000 $7,500 $— $30,000 Interest obligation on long-term debt(2) $2,268 $2,725 $1,438 $— $6,431 Operating lease obligations(3) $3,703 $1,860 $— $— $5,563 Co-investment option(4) $5,000 $3,750 $— $— $8,750 Total obligations $13,471 $28,335 $8,938 $— $47,744 (1)For further discussion regarding long-term debt, see Note 9, “Long-Term Debt” of the Notes to Consolidated Financial Statements. (2)Interest obligation on long-term debt has been calculated based on the interest rate applicable as of December 31, 2016. (3)Our long-term commitment under operating lease relates to payments under our facility lease in South San Francisco, California, which expires in2018. (4)In February 2017, the Company provided notice to Amgen of its further exercise of its co-invest option in the additional amount of $30.0 million (i.e.to fully co-invest $40.0 million) in the Phase 3 development program of omecamtiv mecarbil under the Amgen Agreement. For further discussionregarding co-investment option, see Note 7, “Related Parties and Related Party Transaction” of the Notes to Consolidated Financial Statements. 79Table of ContentsIn future periods, we expect to incur substantial costs as we continue to expand our research programs and related research and development activities.We plan to continue development of our fast skeletal troponin activator tirasemtiv for the potential treatment of ALS. We plan to continue development ofour fast skeletal troponin activator CK-2127107 for the potential treatment of SMA, COPD, ALS and potentially other diseases and conditions related toskeletal muscle weakness or wasting and research of potential next-generation compounds as part of our strategic alliance with Astellas. We plan to continueto support the development of our cardiac muscle myosin activator omecamtiv mecarbil for the potential treatment of heart failure and the research ofpotential next-generation compounds as part of our strategic alliance with Amgen. We expect to incur significant research and development expenses as weadvance the research and development of compounds from our other muscle biology programs through research to candidate selection.Our future capital uses and requirements depend on numerous factors. These factors include, but are not limited to, the following: • the initiation, progress, timing, scope and completion of preclinical research, non-clinical development, chemistry, manufacturing, and controls(CMC), and clinical trials for our drug candidates and other compounds; • the time and costs involved in obtaining regulatory approvals; • delays that may be caused by requirements of regulatory agencies; • Amgen’s decisions with regard to funding of development and commercialization of omecamtiv mecarbil or other compounds for the potentialtreatment of heart failure under our collaboration; • Astellas’ decisions with regard to funding of development and commercialization of CK-2127107 or other skeletal muscle activators under ourcollaboration; • our level of funding for the development of current or future drug candidates; • the number of drug candidates we pursue; • the costs involved in filing and prosecuting patent applications and enforcing or defending patent claims; • our ability to establish and maintain selected strategic alliances required for the development of drug candidates and commercialization of ourpotential drugs; • our plans or ability to expand our drug development capabilities, including our capabilities to conduct clinical trials for our drug candidates; • our plans or ability to engage third party manufacturers for our drug candidates and potential drugs; • our plans or ability to build or access sales and marketing capabilities and to achieve market acceptance for potential drugs; • the expansion and advancement of our research programs; • the hiring of additional employees and consultants; • the expansion of our facilities; • the acquisition of technologies, products and other business opportunities that require financial commitments; and • our revenues, if any, from successful development of our drug candidates and commercialization of potential drugs.We have incurred an accumulated deficit of $518.3 million since inception and there can be no assurance that we will attain profitability. We aresubject to risks common to clinical-stage companies including, but not limited to, development of new drug candidates, dependence on key personnel, andthe ability to obtain 80Table of Contentsadditional capital as needed to fund our future plans. Our liquidity will be impaired if sufficient additional capital is not available on terms acceptable to us,if at all. To date, we have funded our operations primarily through sales of our common stock and convertible preferred stock, contract payments under ourcollaboration agreements, debt financing arrangements, grants and interest income. Until we achieve profitable operations, we intend to continue to fundoperations through payments from strategic collaborations, additional sales of equity securities, grants and debt financings. We have never generatedrevenues from commercial sales of our drugs and may not have drugs to market for at least several years, if ever. Our success is dependent on our ability toobtain additional capital by entering into new strategic collaborations and/or through equity or debt financings, and ultimately on our and our collaborators’ability to successfully develop and market one or more of our drug candidates. We cannot be certain that sufficient funds will be available from suchcollaborators or financings when needed or on satisfactory terms. Additionally, there can be no assurance that any of drugs based on our drug candidates willbe accepted in the marketplace or that any future products can be developed or manufactured at an acceptable cost. These factors could have a materialadverse effect on our future financial results, financial position and cash flows.Based on the current status of our development plans, we believe that our existing cash and cash equivalents, investments and interest earned oninvestments will be sufficient to meet our projected operating requirements for at least the next 12 months. If, at any time, our prospects for internallyfinancing our research and development programs decline, we may decide to reduce research and development expenses by delaying, discontinuing orreducing our funding of development of one or more of our drug candidates or of other research and development programs. Alternatively, we might raisefunds through strategic relationships, public or private financings or other arrangements. There can be no assurance that funding, if needed, will be availableon attractive terms, or at all, or in accordance with our planned timelines. Furthermore, financing obtained through future strategic relationships may requireus to forego certain commercialization and other rights to our drug candidates. Similarly, any additional equity financing may be dilutive to stockholdersand debt financing, if available, may involve restrictive covenants. Our failure to raise capital as and when needed could have a negative impact on ourfinancial condition and our ability to pursue our business strategy.Off-balance Sheet ArrangementsWe are not party to any off-balance sheet arrangements that have, or are reasonably likely to have, a material current or future effect on our financialcondition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources.Critical Accounting Policies and EstimatesOur discussion and analysis of our financial condition and results of operations are based on our financial statements, which have been prepared inaccordance with accounting principles generally accepted in the United States. The preparation of these financial statements requires us to make estimatesand judgments that affect the reported amounts of assets, liabilities and expenses and related disclosure of contingent assets and liabilities. We review ourestimates on an ongoing basis. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable under thecircumstances. Actual results may differ from these estimates under different assumptions or conditions. While our significant accounting policies aredescribed in more detail in the notes to our financial statements included in this Annual Report on Form 10-K, we believe the following accounting policiesto be critical to the judgments and estimates used in the preparation of our financial statements.InvestmentsAvailable-for-sale investments. Our investments consist of U.S. Treasury securities, and money market funds. We designate all investments asavailable-for-sale. Therefore, they are reported at fair value, with unrealized gains and losses recorded in accumulated other comprehensive income. SeeNote 4, “Cash 81Table of ContentsEquivalents and Investments” in the Notes to Consolidated Financial Statements for further detailed discussion. Investments with original maturities greaterthan three months and remaining maturities less than one year are classified as short-term investments. Investments with remaining maturities greater than oneyear are classified as long-term investments. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretion ofdiscounts to maturity. Such amortization is included in interest income. Realized gains and losses and declines in value judged to be other-than-temporary, ifany, on available-for-sale securities are included in other income or expense. Interest and dividends on securities classified as available-for-sale are includedin Interest and Other, net.Other-than-temporary impairment. All of our available-for-sale investments are subject to a periodic impairment review. We recognize an impairmentcharge when a decline in the fair value of our investments below the cost basis is judged to be other-than-temporary. Factors considered by management inassessing whether an other-than-temporary impairment has occurred include: the nature of the investment; whether the decline in fair value is attributable tospecific adverse conditions affecting the investment; the financial condition of the investee; the severity and the duration of the impairment; and whether wehave the intent and ability to hold the investment to maturity. When we determine that an other-than-temporary impairment has occurred, the investment iswritten down to its market value at the end of the period in which we determine that an other-than-temporary decline occurred.Revenue RecognitionWe recognize revenue when the following criteria have been met: persuasive evidence of an arrangement exists; delivery has occurred or services havebeen rendered; the fee is fixed or determinable; and collectability is reasonably assured. Determination of whether persuasive evidence of an arrangementexists and whether delivery has occurred or services have been rendered are based on management’s judgments regarding the fixed nature of the fee chargedfor research performed and milestones met, and the collectability of those fees. Should changes in conditions cause management to determine these criteriaare not met for certain future transactions, revenue recognized for any reporting period could be adversely affected.Revenue under our license and collaboration arrangements is recognized based on the performance requirements of the contract. Research anddevelopment revenues, which are earned under agreements with third parties for agreed research and development activities, may include non-refundablelicense fees, research and development funding, cost reimbursements and contingent milestones and royalties. The Company’s collaborations prior toJanuary 1, 2011 with multiple elements were evaluated and divided into separate units of accounting if certain criteria are met, including whether thedelivered element has stand-alone value to the customer and whether there was vendor-specific objective and reliable evidence (“VSOE”) of the fair value ofthe undelivered items. The consideration the Company received was allocated among the separate units based on their respective fair values, and theapplicable revenue recognition criteria were applied to each of the separate units. The consideration the Company received was combined and recognized asa single unit of accounting when criteria for separation were not met. On January 1, 2011, ASC Topic 605-25, Revenue Recognition — Multiple-ElementArrangements (“ASC 605-25”) on the recognition of revenues for agreements with multiple deliverables became effective and applies to any agreements theCompany entered into on or after January 1, 2011. Under this updated guidance, revenue is allocated to each element using a selling price hierarchy, wherethe selling price for an element is based on VSOE if available; third-party evidence (“TPE”), if available and VSOE is not available; or the best estimate ofselling price, if neither VSOE nor TPE is available.Upfront, non-refundable licensing payments are assessed to determine whether or not the licensee is able to obtain stand-alone value from the license.Where the license does not have stand-alone value, non-refundable license fees are recognized as revenue as we perform under the applicable agreement.Where the level of effort is relatively consistent over the performance period, we recognize total fixed or determined revenue on a straight-line basis over theestimated period of expected performance. Where the license has stand-alone value, we recognize total license revenue at the time all revenue recognitioncriteria have been met. 82Table of ContentsAlso on January 1, 2011, ASC Topic 605-28, Revenue Recognition — Milestone Method (“ASC 605-28”) became effective and established themilestone method as an acceptable method of revenue recognition for certain contingent event-based payments under research and developmentarrangements. Under the milestone method, a payment that is contingent upon the achievement of a substantive milestone is recognized in its entirety in theperiod in which the milestone is achieved. A milestone is an event (i) that can be achieved based in whole or in part on either our performance or on theoccurrence of a specific outcome resulting from our performance, (ii) for which there is substantive uncertainty at the date the arrangement is entered into thatthe event will be achieved, and (iii) that would result in additional payments being due to us. The determination that a milestone is substantive is based onmanagement’s judgment and is made at the inception of the arrangement. Milestones are considered substantive when the consideration earned from theachievement of the milestone is (i) commensurate with either our performance to achieve the milestone or the enhancement of value of the item delivered as aresult of a specific outcome resulting from our performance to achieve the milestone, (ii) relates solely to past performance and (iii) is reasonable relative toall deliverables and payment terms in the arrangement.Other contingent event-based payments received for which payment is either contingent solely upon the passage of time or the results of acollaborative partner’s performance are not considered milestones under ASC 605-28. Such payments will be recognized as revenue when all of the followingcriteria are met: (i) persuasive evidence of an arrangement exists, (ii) delivery has occurred or services have been rendered, (iii) price is fixed or determinable,(iv) and collectability is reasonably assured.We account for milestone payments under the provisions of ASC 605-28. We consider an event to be a milestone if there is substantive uncertainty atthe date the arrangement is entered into that the event will be achieved, if the event can only be achieved with our performance, and if the achievement of theevent results in payment to us. If we determine a milestone is substantive, we recognize revenue when payment is earned and becomes payable. For amilestone to be considered substantive, it must be achieved with our performance, be reasonable relative to the terms of the arrangement and becommensurate with our effort to achieve the milestone or commensurate with the enhanced value of the delivered item(s) as a result of the milestoneachievement. If we determine a milestone is not substantive, we defer the payment and recognize revenue over the estimated period of performance as wecomplete our performance obligations, if any.Research and development revenues and cost reimbursements are based upon negotiated rates for our FTEs and actual out-of-pocket costs. FTE ratesare negotiated rates that are based upon our costs, and which we believe approximate fair value. Any amounts received in advance of performance arerecorded as deferred revenue. None of the revenues recognized to date are refundable if the relevant research effort is not successful. In revenue arrangementsin which both parties make payments to each other, we evaluate the payments to determine whether payments made by us will be recognized as a reduction ofrevenue or as expense. Revenue we recognize may be reduced by payments made to the other party under the arrangement unless we receive a separate andidentifiable benefit in exchange for the payments and we can reasonably estimate the fair value of the benefit received. In arrangements in which we are theprimary obligor, we record expense reimbursements from the other party as research and development revenue. If we are not the primary obligor, we recordpayments as a reduction of revenue.Funds received from third parties under grant arrangements are recorded as revenue if we are deemed to be the principal participant in the grantarrangement as the activities under the grant are part of our development programs. If we are not the principal participant, the grant funds are recorded as areduction to research and development expense. Grant funds received are not refundable and are recognized when the related qualified research anddevelopment costs are incurred and when there is reasonable assurance that the funds will be received. Funds received in advance are recorded as deferredrevenue. 83Table of ContentsPreclinical Study and Clinical Trial AccrualsA substantial portion of our preclinical studies and all of our clinical trials have been performed utilizing third-party contract research organizations(“CROs”) and other vendors. For preclinical studies, the significant factors used in estimating accruals include the percentage of work completed to date andcontract milestones achieved. For clinical trial expenses, the significant factors used in estimating accruals include the number of patients enrolled, durationof enrollment and percentage of work completed to date. We monitor patient enrollment levels and related activities to the extent possible through internalreviews, correspondence and status meetings with CROs and review of contractual terms. Our estimates are dependent on the timeliness and accuracy of dataprovided by our CROs and other vendors. If we have incomplete or inaccurate data, we may under- or overestimate activity levels associated with variousstudies or clinical trials at a given point in time. In this event, we could record adjustments to research and development expenses in future periods when theactual activity levels become known.Stock-Based CompensationWe apply the accounting guidance for stock compensation, which establishes the accounting for share-based payment awards made to employees anddirectors, including employee stock options and employee stock purchases. Under this guidance, stock-based compensation cost is measured at the grant datebased on the calculated fair value of the award, and is recognized as an expense on a straight-line basis over the employee’s requisite service period,generally the vesting period of the award.Under the guidance for stock compensation for non-employees, we measure the fair value of the award each period until the award is fully vested.Compensation cost for restricted stock awards that contain performance conditions is based on the grant date fair value of the award and compensationexpense is recorded over the implicit or explicit requisite service period based on management’s best estimate as to whether it is probable that the sharesawarded are expected to vest.As required under the accounting rules, we review our valuation assumptions at each grant date and, as a result, from time to time we will likely changethe valuation assumptions we use to value stock based awards granted in future periods. The assumptions used in calculating the fair value of share-basedpayment awards represent management’s best estimates at the time, but these estimates involve inherent uncertainties and the application of managementjudgment. As a result, if conditions change and we use different assumptions, our stock-based compensation expense could be materially different in thefuture. In addition, we are required to estimate the expected forfeiture rate and recognize expense only for those shares expected to vest. If our actualforfeiture rate is materially different from our estimate, the stock-based compensation expense could be significantly different from what we have recorded inthe current period.Income TaxesWe account for income taxes under the asset and liability method. Under this method, deferred tax assets and liabilities are determined based on thedifference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences areexpected to affect taxable income. Valuation allowances are established when necessary to reduce the deferred tax assets to the amounts expected to berealized. We did not record an income tax provision in the years ended December 31, 2016, 2015 or 2014 because we either had net taxable losses in theseperiods or was able to utilize tax attributes to offset taxable income.Based upon the weight of available evidence, which includes our historical operating performance, reported cumulative net losses since inception,expected future losses, and difficulty in accurately forecasting our future results, we maintained a full valuation allowance on the net deferred tax assets as ofDecember 31, 2016, 2015 and 2014. The valuation allowance was determined pursuant to the accounting guidance for income taxes, which 84Table of Contentsrequires an assessment of both positive and negative evidence when determining whether it is more likely than not that deferred tax assets are recoverable.We intend to maintain a full valuation allowance on the U.S. deferred tax assets until sufficient positive evidence exists to support reversal of the valuationallowance. The valuation allowance decreased by $2.2 million in 2016 and increased by $13.9 million in 2015 and $1.0 million in 2014.We also follow the accounting guidance that defines the threshold for recognizing the benefits of tax return positions in the financial statements as“more-likely-than-not” to be sustained by the taxing authorities based solely on the technical merits of the position. If the recognition threshold is met, thetax benefit is measured and recognized as the largest amount of tax benefit that, in our judgment, is greater than 50% likely to be realized.Interest accrued related to unrecognized tax benefits and penalties was zero for 2016, 2015 and 2014. We account for interest related to unrecognizedtax benefits and penalties by classifying both as income tax expense in the financial statements in accordance with the accounting guidance for uncertaintyin income taxes. We do not expect our unrecognized tax benefits to change materially over the next twelve months.The significant jurisdictions in which we file income tax returns are the United States and the state of California. For jurisdictions in which tax filingsare made, we are subject to income tax examination for all fiscal years since inception. The IRS’s Large Business and International Division concluded itsaudit of the 2009 tax year with no material adjustments. However, in general, the statute of limitations for tax liabilities for these years remains open for thepurpose of adjusting the amounts of the losses and credits carried forward from those years. We believe that we maintain adequate reserves for uncertain taxpositions.In general, under Section 382 of the Internal Revenue Code (“Section 382”), a corporation that undergoes an ‘ownership change’ is subject tolimitations on its ability to utilize its pre-change net operating losses (“NOLs”) and tax credits to offset future taxable income. We have performed aSection 382 analysis and do not believe that we have experienced an ownership change since 2006. A portion of our existing NOLs and tax credits aresubject to limitations arising from previous ownership changes. Future changes in our stock ownership, some of which are outside of our control, could resultin an ownership change under Section 382 and result in additional limitations.Recent Accounting PronouncementsSee “Recent Accounting Pronouncements” in Note 1, “Organization and Significant Accounting Policies” in the Notes to Consolidated FinancialStatements for a discussion of recently adopted accounting pronouncements and accounting pronouncements not yet adopted, and their expected impact onour financial position and results of operations.Item 7A. Quantitative and Qualitative Disclosures About Market RiskInterest Rate and Market RiskInvestmentsOur exposure to market risk is limited to interest rate sensitivity, which is affected by changes in the general level of U.S. interest rates, particularlybecause the majority of our investments are in short-term debt securities. The primary objective of our investment activities is to preserve principal while atthe same time maximizing the income we receive without significantly increasing risk. We are exposed to the impact of interest rate changes and changes inthe market values of our investments. Our interest income is sensitive to changes in the general level of U.S. interest rates. Our exposure to market rate risk forchanges in interest rates relates primarily to our investment portfolio. We have not used derivative financial instruments in our investment portfolio. Weinvest the majority of our excess cash in U.S. Treasuries and, by policy, limit the amount of credit exposure in any one issuer and investment class, with theexception of obligations of the U.S. Treasury and federal agencies, for which there are no such limits. We protect and preserve our invested funds byattempting to limit default, market 85Table of Contentsand reinvestment risk. Investments in both fixed-rate and floating-rate interest-earning instruments carry a degree of interest rate risk. Fixed-rate securitiesmay have their fair market value adversely impacted due to a rise in interest rates, while floating-rate securities may produce less income than expected ifinterest rates fall. Due in part to these factors, our future investment income may fall short of expectations due to changes in interest rates. To minimize risk,we maintain our portfolio of cash and cash equivalents and short- and long-term investments in a variety of interest-bearing instruments, includingU.S. government and agency securities, high grade municipal and U.S. bonds and money market funds. Our investment portfolio of short- and long-terminvestments is subject to interest rate risk, and will fall in value if market interest rates increase.Our cash and cash equivalents are invested in highly liquid securities with maturities of three months or less at the time of purchase. Consequently, wedo not consider our cash and cash equivalents to be subject to significant interest rate risk and have therefore excluded them from the table below. We do nothave any foreign currency or derivative financial instruments.The table below presents the principal amounts and weighted average interest rates by year of maturity for our investment portfolio (dollars inthousands): 2017 Fair Value atDecember 31,2016 Assets: Investments, Short Term $89,375 $89,375 Average interest rate 0.6% Investments — U.S. Treasury, Long Term $7,496 $7,496 Average interest rate 0.8% Long Term DebtPrincipal payments on our Loan Agreement are paid in 36 equal installments beginning on October 2017 with the outstanding balance to be repaid inOctober 2020. The loan bears interest at a rate of 7.5% per annum. The outstanding borrowings carry a fixed interest rate, however, changes in market interestrates may affect the fair value of the loan, but do not impact earnings or cash flows. The net carrying value of the Loan Agreement as of December 31, 2016 is$29.9 million and approximates fair value. Borrowings under the Loan Agreement as of December 31, 2016 totaled $30 million with a weighted averageinterest rate of 7.5%.The following are the future payments under the terms of the Loan Agreement: 2017 $4,768 2018 11,743 2019 10,982 2020 8,938 Total minimum payments 36,431 Less: Interest and final payment (6,431) Notes payable, gross $30,000 86Table of ContentsItem 8. Financial Statements and Supplementary Data CYTOKINETICS, INCORPORATEDINDEX TO FINANCIAL STATEMENTS Page Report of Independent Registered Public Accounting Firm 88 Consolidated Balance Sheets 89 Consolidated Statement of Operations and Comprehensive Income (Loss) 90 Consolidated Statements of Stockholders’ Equity 91 Consolidated Statements of Cash Flows 92 Notes to Consolidated Financial Statements 93 87Table of ContentsREPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMTo the Board of Directors and Stockholders of Cytokinetics, Incorporated:In our opinion, the accompanying consolidated balance sheets and the related consolidated statements of operations and comprehensive income (loss),of stockholders’ equity and of cash flows present fairly, in all material respects, the financial position of Cytokinetics, Incorporated and its subsidiary as ofDecember 31, 2016 and 2015, and the results of their operations and their cash flows for each of the three years in the period ended December 31, 2016 inconformity with accounting principles generally accepted in the United States of America. Also in our opinion, the Company maintained, in all materialrespects, effective internal control over financial reporting as of December 31, 2016, based on criteria established in Internal Control — IntegratedFramework 2013 issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). The Company’s management is responsiblefor these financial statements, for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal controlover financial reporting, included in Management’s Report on Internal Control over Financial Reporting appearing under Item 9A. Our responsibility is toexpress opinions on these financial statements and on the Company’s internal control over financial reporting based on our integrated audits. We conductedour audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan andperform the audits to obtain reasonable assurance about whether the financial statements are free of material misstatement and whether effective internalcontrol over financial reporting was maintained in all material respects. Our audits of the financial statements included examining, on a test basis, evidencesupporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management,and evaluating the overall financial statement presentation. Our audit of internal control over financial reporting included obtaining an understanding ofinternal control over financial reporting, assessing the risk that a material weakness exists, and testing and evaluating the design and operating effectivenessof internal control based on the assessed risk. Our audits also included performing such other procedures as we considered necessary in the circumstances. Webelieve that our audits provide a reasonable basis for our opinions.A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financialreporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’sinternal control over financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail,accurately and fairly reflect the transactions and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions are recorded asnecessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of thecompany are being made only in accordance with authorizations of management and directors of the company; and (iii) provide reasonable assuranceregarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on thefinancial statements.Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of anyevaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degreeof compliance with the policies or procedures may deteriorate./s/ PRICEWATERHOUSECOOPERS LLPSan Jose, CaliforniaMarch 6, 2017 88Table of ContentsCYTOKINETICS, INCORPORATEDCONSOLIDATED BALANCE SHEETS December 31, 2016 2015 (In thousands, exceptshare and per share data) ASSETS Current assets: Cash and cash equivalents $66,874 $65,076 Short-term investments 89,375 46,366 Related party accounts receivable 24 12 Prepaid and other current assets 2,360 1,653 Total current assets 158,633 113,107 Long-term investments 7,672 179 Property and equipment, net 3,637 1,751 Other assets 200 200 Total assets $170,142 $115,237 LIABILITIES AND STOCKHOLDERS’ EQUITY Current liabilities: Accounts payable $4,236 $2,238 Accrued liabilities 18,047 8,421 Deferred revenue, current 8,060 20,858 Current portion of long-term debt 2,500 — Short-term portion of deferred rent and interest payable 415 132 Total current liabilities 33,258 31,649 Long-term debt 27,381 14,639 Deferred revenue, non-current 15,000 — Long-term portion of deferred rent 142 359 Total liabilities 75,781 46,647 Commitments and contingencies (Note 10) Stockholders’ equity: Preferred stock, $0.001 par value: Authorized: 10,000,000 shares; Issued and outstanding: Series A Convertible Preferred Stock — zero shares at December 31, 2016 and December 31, 2015 — — Common stock, $0.001 par value: Authorized: 163,000,000 shares at December 31, 2016 and 81,500,000 shares at December 31, 2015; Issued and outstanding: 40,646,595 shares at December 31, 2016 and 39,581,692 shares at December 31, 2015 41 40 Additional paid-in capital 612,474 603,145 Accumulated other comprehensive income 137 149 Accumulated deficit (518,291) (534,744) Total stockholders’ equity 94,361 68,590 Total liabilities and stockholders’ equity $170,142 $115,237 The accompanying notes are an integral part of these consolidated financial statements. 89Table of ContentsCYTOKINETICS, INCORPORATEDCONSOLIDATED STATEMENT OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) Years Ended December 31, 2016 2015 2014 (In thousands, except per share data) Revenues: Research and development revenues from related parties, net $42,994 $14,665 $19,538 Research and development, grant and other revenues 1,242 75 17,566 License revenues from related parties 62,171 13,918 — License revenues — — 9,836 Total revenues 106,407 28,658 46,940 Operating expenses: Research and development 59,897 46,398 44,426 General and administrative 27,823 19,667 17,268 Total operating expenses 87,720 66,065 61,694 Operating income (loss) 18,687 (37,407) (14,754) Interest expense (2,698) (268) — Interest and other income, net 464 174 108 Income (loss) before income taxes 16,453 (37,501) (14,646) Income tax benefit — — — Net income (loss) $16,453 $(37,501) $(14,646) Net income (loss) per share — basic $0.41 $(0.97) $(0.41) Net income (loss) per share — diluted $0.39 $(0.97) $(0.41) Weighted-average number of shares used in computing net income (loss) per share — basic 39,943 38,814 35,709 Weighted-average number of shares used in computing net income (loss) per share — diluted 42,561 38,814 35,709 Other comprehensive income (loss): Unrealized gains (losses) on available-for-sale securities, net (12) 153 (11) Comprehensive income (loss) $16,441 $(37,348) $(14,657) The accompanying notes are an integral part of these consolidated financial statements. 90Table of ContentsCYTOKINETICS, INCORPORATEDCONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY Common Stock AdditionalPaid-In AccumulatedOtherComprehensiveIncome Accumulated TotalStockholders’ Shares Amount Capital (Loss) Deficit Equity (In thousands, except share and per share data) Balance, December 31, 2013 30,681,624 $31 $537,001 $7 $(482,597) $54,442 Issuance of common stock upon exercise of stock options for cash at $6.00 per share 390 — 2 — — 2 Issuance of common stock pursuant to ESPP at a weighted price of $3.38 per share 19,726 — 67 — — 67 Issuance of common stock upon vesting of restricted stock units, net of taxes withheld 11,704 — (96) — — (96) Issuance of common stock upon exercise of warrants 510,125 1 5 — — 6 Issuance of common stock to MLV at $6.64-$6.79 per share, net of commission andissuance costs of $74 364,103 — 2,376 — — 2,376 Issuance of common stock to collaborative partner for $4.90 per share, net of issuancecosts of $8 2,040,816 2 9,100 — — 9,102 Issuance of common stock pursuant to February 2014 public offerings at $8.00 per share,net of issuance costs of $2,800 5,031,250 5 37,487 — — 37,492 Stock-based compensation — — 3,330 — — 3,330 Other comprehensive loss — — — (11) — (11) Net loss — — — — (14,646) (14,646) Balance, December 31, 2014 38,659,738 $39 $589,272 $(4) $(497,243) $92,064 Issuance of common stock upon exercise of stock options at a weighted price of $6.22 pershare 68,635 — 427 — — 427 Issuance of common stock pursuant to ESPP at a weighted price of $3.24 per share 21,167 — 69 — — 69 Issuance of common stock upon vesting of restricted stock units, net of taxes withheld 23,725 — (144) — — (144) Issuance of common stock upon exercise of warrants 234 — — — — — Issuance of common stock under CE Offering at $7.00-$12.68 per share, net ofcommission and issuance costs of $205 808,193 1 8,672 — — 8,673 Issuance of warrants pursuant to the Loan Agreement — — 282 — — 282 Stock-based compensation — — 4,567 — — 4,567 Other comprehensive income — — — 153 — 153 Net loss — — — — (37,501) (37,501) Balance, December 31, 2015 39,581,692 $40 $603,145 $149 $(534,744) $68,590 Issuance of common stock upon exercise of stock options at a weighted price of $6.75 pershare 74,556 — 503 — — 503 Issuance of common stock pursuant to ESPP at a weighted price of $7.08 per share 129,604 — 917 — — 917 Issuance of common stock upon vesting of restricted stock units, net of taxes withheld 25,745 — (135) — — (135) Issuance of common stock upon exercise of warrants 834,998 1 610 — — 611 Issuance of warrants pursuant to the Loan Agreement — — 288 — — 288 Stock-based compensation — — 7,146 — — 7,146 Other comprehensive loss — — — (12) — (12) Net income — — — — 16,453 16,453 Balance, December 31, 2016 40,646,595 $41 $612,474 $137 $(518,291) $94,361 The accompanying notes are an integral part of these consolidated financial statements. 91Table of ContentsCYTOKINETICS, INCORPORATEDCONSOLIDATED STATEMENTS OF CASH FLOWS Years Ended December 31, 2016 2015 2014 (In thousands) Cash flows from operating activities: Net income (loss) $16,453 $(37,501) $(14,646) Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: Depreciation and amortization of property and equipment 741 589 490 Gain on disposal of equipment (18) (18) — Non-cash interest expense 534 3 — Stock-based compensation 7,146 4,567 3,330 Gain on sale of investments — (3) (6) Changes in operating assets and liabilities: Related party accounts receivable (12) 46,634 (46,641) Prepaid and other assets (707) (396) 274 Accounts payable 1,698 755 (2,178) Accrued and other liabilities 8,945 2,995 (2,865) Deferred revenue 2,202 (12,742) 17,399 Net cash provided by (used in) operating activities 36,982 4,883 (44,843) Cash flows from investing activities: Purchases of investments (145,158) (115,566) (107,043) Proceeds from sales and maturities of investments 94,645 132,190 104,098 Purchases of property and equipment (1,596) (562) (1,104) Proceeds from sales of property and equipment 33 1 — Net cash provided by (used in) investing activities (52,076) 16,063 (4,049) Cash flows from financing activities: Proceeds from public offerings of common stock, net of issuance costs — 8,673 48,971 Proceeds from long term debt, net of debt discount and issuance costs 14,996 14,890 — Proceeds (payments) from stock based award activities and warrants, net 1,896 352 (22) Net cash provided by financing activities 16,892 23,915 48,949 Net increase in cash and cash equivalents 1,798 44,861 57 Cash and cash equivalents, beginning of period 65,076 20,215 20,158 Cash and cash equivalents, end of period $66,874 $65,076 $20,215 The accompanying notes are an integral part of these consolidated financial statements. 92Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTSNote 1 — Organization and Significant Accounting PoliciesOrganizationCytokinetics, Incorporated (the “Company”, “we” or “our”) was incorporated under the laws of the state of Delaware on August 5, 1997. The Companyis a late stage biopharmaceutical company focused on the discovery and development of novel small molecule therapeutics that modulate muscle functionfor the potential treatment of serious diseases and medical conditions.The Company’s financial statements contemplate the conduct of the Company’s operations in the normal course of business. The Company hasincurred an accumulated deficit of $518.3 million since inception and there can be no assurance that the Company will attain profitability. The Companyhad net income of $16.4 million and net cash provided by operations of $37.0 million for the year ended December 31, 2016. Cash, cash equivalents andinvestments increased to $163.9 million at December 31, 2016 from $111.6 million at December 31, 2015. The Company anticipates that it will haveoperating losses and net cash outflows in future periods.The Company is subject to risks common to late stage biopharmaceutical companies including, but not limited to, development of new drugcandidates, dependence on key personnel, and the ability to obtain additional capital as needed to fund its future plans. The Company’s liquidity will beimpaired if sufficient additional capital is not available on terms acceptable to the Company. To date, the Company has funded its operations primarilythrough sales of its common stock and convertible preferred stock, contract payments under its collaboration agreements, debt financing arrangements,government grants and interest income. Until it achieves profitable operations, the Company intends to continue to fund operations through payments fromstrategic collaborations, additional sales of equity securities, grants and debt financings. The Company has never generated revenues from commercial salesof its drugs and may not have drugs to market for at least several years, if ever. The Company’s success is dependent on its ability to enter into new strategiccollaborations and/or raise additional capital and to successfully develop and market one or more of its drug candidates. As a result, the Company maychoose to raise additional capital through equity or debt financings to continue to fund its operations in the future. The Company cannot be certain thatsufficient funds will be available from such a financing or through a collaborator when required or on satisfactory terms. Additionally, there can be noassurance that the Company’s drug candidates will be accepted in the marketplace or that any future products can be developed or manufactured at anacceptable cost. These factors could have a material adverse effect on the Company’s future financial results, financial position and cash flows.Based on the current status of its research and development plans, the Company believes that its existing cash, cash equivalents and investments willbe sufficient to fund its cash requirements for at least the next 12 months. If, at any time, the Company’s prospects for financing its research and developmentprograms decline, the Company may decide to reduce research and development expenses by delaying, discontinuing or reducing its funding of one or moreof its research or development programs. Alternatively, the Company might raise funds through strategic collaborations, public or private financings or otherarrangements. Such funding, if needed, may not be available on favorable terms, or at all. The financial statements do not include any adjustments that mightresult from the outcome of this uncertainty.Use of EstimatesThe preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to makeestimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of thefinancial statements and the 93Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.Basis of PresentationThe consolidated financial statements include the accounts of Cytokinetics and its wholly owned subsidiary and have been prepared in accordancewith U.S. generally accepted accounting principles (“US GAAP”). Intercompany transactions and balances have been eliminated in consolidation.Concentration of Credit Risk and Other Risks and UncertaintiesFinancial instruments that potentially subject the Company to concentrations of risk consist principally of cash and cash equivalents, investments,long term debt and accounts receivable.The Company’s cash, cash equivalents and investments are invested in deposits with three major financial institutions in the United States. Deposits inthese banks may exceed the amount of insurance provided on such deposits. The Company has not experienced any realized losses on its deposits of cash,cash equivalents or investments.The economic turmoil in the United States in recent years, the extraordinary volatility in the stock markets and other current negative macroeconomicindicators could negatively impact the Company’s ability to raise the funds necessary to support its business and may materially adversely affect its business,operating results and financial condition.The Company performs an ongoing credit evaluation of its strategic partners’ financial conditions and generally does not require collateral to secureaccounts receivable from its strategic partners. The Company’s exposure to credit risk associated with non-payment will be affected principally by conditionsor occurrences within Amgen Inc. (“Amgen”) and Astellas Pharma Inc. (“Astellas”), its strategic partners. Approximately 26%, 9% and 10% of total revenuesfor the years ended December 31, 2016, 2015 and 2014, respectively, were derived from Amgen. There were no accounts receivable due from Amgen atDecember 31, 2016 and 2015. Approximately 73%, 91% and 90% of total revenues for the years ended December 31, 2016, 2015 and 2014, respectively,were derived from Astellas. There were no accounts receivable due from Astellas at December 31, 2016 and 2015. See also Note 7, “Related PartyTransactions,” regarding the collaboration agreements with Amgen and Astellas.Drug candidates developed by the Company may require approvals or clearances from the U.S. Food and Drug Administration (“FDA”) or internationalregulatory agencies prior to commercial sales. There can be no assurance that the Company’s drug candidates will receive any of the required approvals orclearances. If the Company was to be denied approval or clearance or any such approval or clearance was to be delayed, it would have a material adverseimpact on the Company.The Company’s operations and employees are located in the United States. In the year ended December 31, 2016, 27% of the Company’s revenueswere received from entities located in the United States and 73% were received from a Japanese entity. In the year ended December 31, 2015, 9% of theCompany’s revenues were received from entities located in the United States and 91% were received from a Japanese entity. In the year ended December 31,2014, 10% of the Company’s revenues were received from entities located in the United States and 90% were received from a Japanese entity. 94Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Cash and Cash EquivalentsThe Company considers all highly liquid investments with a maturity of three months or less at the time of purchase to be cash equivalents.InvestmentsAvailable-for-sale investments. The Company’s investments consist of U.S. Treasury securities, and money market funds. The Company designatesall investments as available-for-sale and therefore reports them at fair value, based on quoted marked prices, with unrealized gains and losses recorded inaccumulated other comprehensive loss. The cost of securities sold is based on the specific-identification method. Investments with original maturities greaterthan three months and remaining maturities of one year or less are classified as short-term investments. Investments with remaining maturities greater thanone year are classified as long-term investments. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretionof discounts to maturity. Such amortization is included in interest income. Recognized gains and losses and declines in value judged to be other-than-temporary, if any, on available-for-sale securities are included in other income or expense. Interest and dividends on securities classified as available-for-saleare included in Interest and other, net.Other-than-temporary impairment. All of the Company’s available-for-sale investments are subject to a periodic impairment review. The Companyrecognizes an impairment charge when a decline in the fair value of its investments below the cost basis is judged to be other-than-temporary. Factorsconsidered by management in assessing whether an other-than-temporary impairment has occurred include: the nature of the investment; whether the declinein fair value is attributable to specific adverse conditions affecting the investment; the financial condition of the investee; the severity and the duration of theimpairment; and whether the Company has the intent and ability to hold the investment to maturity. When the Company determines that an other-than-temporary impairment has occurred, the investment is written down to its market value at the end of the period in which it is determined that an other-than-temporary decline has occurred.Fair Value of Financial InstrumentsThe fair value of financial instruments reflects the amounts that would be received upon the sale of an asset or paid to transfer a liability in an orderlytransaction between market participants at the measurement date.Cash, accounts payable and accrued liabilities are carried at cost, which approximates fair value given their short-term nature. Marketable securitiesand cash equivalents, are carried at fair value.Property and Equipment, netProperty and equipment are stated at cost less accumulated depreciation and are depreciated on a straight-line basis over the estimated useful lives ofthe related assets, which are generally three years for computer equipment and software, five years for laboratory equipment and office equipment, and sevenyears for furniture and fixtures. Amortization of leasehold improvements is computed using the straight-line method over the shorter of the remaining leaseterm or the estimated useful life of the related assets, typically ranging from three to seven years. Upon sale or retirement of assets, the costs and relatedaccumulated depreciation and amortization are removed from the balance sheet and the resulting gain or loss is reflected in operations. Maintenance andrepairs are charged to operations as incurred. 95Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Impairment of Long-lived AssetsIn accordance with the accounting guidance for the impairment or disposal of long-lived assets, the Company reviews long-lived assets, includingproperty and equipment, for impairment whenever events or changes in business circumstances indicate that the carrying amount of the assets may not befully recoverable. Under the accounting guidance, an impairment loss would be recognized when estimated undiscounted future cash flows expected to resultfrom the use of the asset and its eventual disposition are less than its carrying amount. Impairment, if any, is measured as the amount by which the carryingamount of a long-lived asset exceeds its fair value.Revenue RecognitionThe accounting guidance for revenue recognition requires that the following criteria must be met before revenue can be recognized: (i) persuasiveevidence of an arrangement exists; (ii) delivery has occurred or services have been rendered; (iii) the fee is fixed or determinable; and (iv) collectability isreasonably assured. Determination of whether persuasive evidence of an arrangement exists and whether delivery has occurred or services have been renderedare based on management’s judgments regarding the fixed nature of the fee charged for research performed and milestones met, and the collectability of thosefees. Should changes in conditions cause management to determine these criteria are not met for certain future transactions, revenue recognized for anyreporting period could be adversely affected.Revenue under the Company’s license and collaboration arrangements is recognized based on the performance requirements of the contract. Researchand development revenues, which are earned under agreements with third parties for agreed research and development activities, may include non-refundablelicense fees, research and development funding, cost reimbursements and contingent milestones and royalties. The Company’s collaborations prior toJanuary 1, 2011 with multiple elements were evaluated and divided into separate units of accounting if certain criteria are met, including whether thedelivered element has stand-alone value to the customer and whether there was vendor-specific objective and reliable evidence (“VSOE”) of the fair value ofthe undelivered items. The consideration the Company received was allocated among the separate units based on their respective fair values, and theapplicable revenue recognition criteria were applied to each of the separate units. The consideration the Company received was combined and recognized asa single unit of accounting when criteria for separation were not met. On January 1, 2011, ASC Topic 605-25, Revenue Recognition — Multiple-ElementArrangements (“ASC 605-25”) on the recognition of revenues for agreements with multiple deliverables became effective and applies to any agreements theCompany entered into on or after January 1, 2011. Under this updated guidance, revenue is allocated to each element using a selling price hierarchy, wherethe selling price for an element is based on VSOE if available; third-party evidence (“TPE”), if available and VSOE is not available; or the best estimate ofselling price, if neither VSOE nor TPE is available.Upfront, non-refundable licensing payments are assessed to determine whether or not the licensee is able to obtain stand-alone value from the license.Where the license does not have stand-alone value, non-refundable license fees are recognized as revenue as the Company performs under the applicableagreement. Where the level of effort is relatively consistent over the performance period, the Company recognizes total fixed or determined revenue on astraight-line basis over the estimated period of expected performance. Where the license has stand-alone value, the Company recognizes total license revenueat the time all revenue recognition criteria have been met.ASC Topic 605-28, Revenue Recognition — Milestone Method (“ASC 605-28”), established the milestone method as an acceptable method of revenuerecognition for certain contingent event-based payments under research and development arrangements. Under the milestone method, a payment that iscontingent upon the 96Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. A milestone is an event (i) that can beachieved based in whole or in part on either the Company’s performance or on the occurrence of a specific outcome resulting from the Company’sperformance, (ii) for which there is substantive uncertainty at the date the arrangement is entered into that the event will be achieved, and (iii) that wouldresult in additional payments being due to the Company. The determination that a milestone is substantive is judgmental and is made at the inception of thearrangement. Milestones are considered substantive when the consideration earned from the achievement of the milestone is (i) commensurate with either theCompany’s performance to achieve the milestone or the enhancement of value of the item delivered as a result of a specific outcome resulting from theCompany’s performance to achieve the milestone, (ii) relates solely to past performance and (iii) is reasonable relative to all deliverables and payment termsin the arrangement.Other contingent event-based payments received for which payment is either contingent solely upon the passage of time or the results of acollaborative partner’s performance are not considered milestones under ASC 605-28. Such payments will be recognized as revenue when all of the followingcriteria are met: (i) persuasive evidence of an arrangement exists, (ii) delivery has occurred or services have been rendered, (iii) price is fixed or determinable,and (iv) collectability is reasonably assured.The Company accounts for milestone payments under the provisions of ASC 605-28. The Company considers an event to be a milestone if there issubstantive uncertainty at the date the arrangement is entered into that the event will be achieved, if the event can only be achieved with the Company’sperformance, and if the achievement of the event results in payment to the Company. If the Company determines a milestone is substantive, the Companyrecognizes revenue when payment is earned and becomes payable. For a milestone to be considered substantive, it must be achieved with the Company’sperformance, be reasonable relative to the terms of the arrangement and be commensurate with the Company’s effort to achieve the milestone orcommensurate with the enhanced value of the delivered item(s) as a result of the milestone achievement. If the Company determines a milestone is notsubstantive, the Company defers the payment and recognizes revenue over the estimated remaining period of performance as the Company completes itsperformance obligations, if any.Research and development revenues and cost reimbursements are based upon negotiated rates for the Company’s full-time employee equivalents(“FTE”) and actual out-of-pocket costs. FTE rates are negotiated rates that are based upon the Company’s costs, and which the Company believesapproximate fair value. Any amounts received in advance of performance are recorded as deferred revenue. None of the revenues recognized to date arerefundable if the relevant research effort is not successful. In revenue arrangements in which both parties make payments to each other, the Companyevaluates the payments in accordance with the accounting guidance for arrangements under which consideration is given by a vendor to a customer,including a reseller of the vendor’s products, to determine whether payments made by us will be recognized as a reduction of revenue or as expense. Inaccordance with this guidance, revenue recognized by the Company may be reduced by payments made to the other party under the arrangement unless theCompany receives a separate and identifiable benefit in exchange for the payments and the Company can reasonably estimate the fair value of the benefitreceived. In arrangements in which the Company is the primary obligor, the Company records expense reimbursements from the other party as research anddevelopment revenue. If the Company is not the primary obligor, the Company records payments as a reduction of revenue.Funds received from third parties under grant arrangements are recorded as revenue if the Company is deemed to be the principal participant in thegrant arrangement as the activities under the grant are part of the Company’s development program. If the Company is not the principal participant, the grantfunds are recorded as 97Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) a reduction to research and development expense. Grant funds received are not refundable and are recognized when the related qualified research anddevelopment costs are incurred and when there is reasonable assurance that the funds will be received. Funds received in advance are recorded as deferredrevenue.Preclinical Studies and Clinical Trial AccrualsA substantial portion of the Company’s preclinical studies and all of the Company’s clinical trials have been performed by third-party contract researchorganizations (“CROs”) and other vendors. For preclinical studies, the significant factors used in estimating accruals include the percentage of workcompleted to date and contract milestones achieved. For clinical trial expenses, the significant factors used in estimating accruals include the number ofpatients enrolled, duration of enrollment and percentage of work completed to date. The Company monitors patient enrollment levels and related activities tothe extent practicable through internal reviews, correspondence and status meetings with CROs, and review of contractual terms. The Company’s estimatesare dependent on the timeliness and accuracy of data provided by its CROs and other vendors. If the Company has incomplete or inaccurate data, it mayunder- or overestimate activity levels associated with various studies or trials at a given point in time. In this event, it could record adjustments to researchand development expenses in future periods when the actual activity level becomes known.Research and Development ExpendituresResearch and development costs are charged to operations as incurred. Research and development expenses consist primarily of clinical manufacturingcosts, preclinical study expenses, consulting and other third party costs, employee compensation, supplies and materials, allocation of overhead andoccupancy costs, facilities costs and depreciation of equipment.Income TaxesThe Company accounts for income taxes under the asset and liability method. Under this method, deferred tax assets and liabilities are determinedbased on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which thedifferences are expected to affect taxable income. Valuation allowances are established when necessary to reduce deferred tax assets to the amounts expectedto be realized.The Company also follows the accounting guidance that defines the threshold for recognizing the benefits of tax return positions in the financialstatements as “more-likely-than-not” to be sustained by the taxing authorities based solely on the technical merits of the position. If the recognitionthreshold is met, the tax benefit is measured and recognized as the largest amount of tax benefit that, in the Company’s judgment, is greater than 50% likelyto be realized.Comprehensive Income (Loss)The Company follows the accounting standards for the reporting and presentation of comprehensive income (loss) and its components in a continuousstatement of comprehensive income (loss). Comprehensive income (loss) includes all changes in stockholders’ equity during a period from non-ownersources. Comprehensive income (loss) for each of the years ended December 31, 2016, 2015, and 2014 was equal to net loss adjusted for unrealized gains andlosses on investments. 98Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Segment ReportingThe Company has determined that it operates in only one segment — the discovery and development of first-in-class muscle activator therapies.Stock-Based CompensationThe Company accounts for stock-based payment awards made to employees and directors, including employee stock options and employee stockpurchases by measuring the stock-based compensation cost at the grant date based on the calculated fair value of the award, and recognizing expense on astraight-line basis over the employee’s requisite service period, generally the vesting period of the award. Stock compensation for non-employees is measuredat the fair value of the award for each period until the award is fully vested. Compensation cost for restricted stock awards that contain performanceconditions is based on the grant date fair value of the award and compensation expense is recorded over the implicit or explicit requisite service period basedon management’s best estimate as to whether it is probable that the shares awarded are expected to vest.The Company reviews the valuation assumptions at each grant date and, as a result, from time to time it will likely change the valuation assumptions ituses to value stock based awards granted in future periods. The assumptions used in calculating the fair value of share-based payment awards representmanagement’s best estimates at the time, but these estimates involve inherent uncertainties and the application of management judgment. As a result, ifconditions change and the management uses different assumptions, the Company’s stock-based compensation expense could be materially different in thefuture. In addition, the Company is required to estimate the expected forfeiture rate and recognize expense only for those shares expected to vest. If the actualforfeiture rate is materially different from management’s estimate, stock-based compensation expense could be significantly different from what has beenrecorded in the current period.Recent Accounting PronouncementsIn August 2016, the FASB issued ASU 2016-15, ‘Statement of cash flows (Topic 230): Classification of certain cash receipts and cash payments’.ASU 2016-15 issued guidance to clarify how certain cash receipts and payments should be presented in the statement of cash flows. ASU 2016-15 is effectivefor annual and interim reporting periods beginning after December 15, 2017 and early adoption is permitted. The Company does not expect the adoption ofthis standard to have a material effect on its financial statements or disclosures.In June 2016, the FASB issued ASU 2016-13, ‘Financial Instruments — Credit Losses — Measurement of Credit Losses on Financial Instruments.ASU 2016-13 changes the impairment model for most financial assets and certain other instruments. ASU 2016-13 is effective for annual and interimreporting periods beginning after December 15, 2019. The Company is in the process of evaluating the impact the adoption of this standard would have onits financial statements and disclosures.In March 2016, the FASB issued ASU 2016-09, Stock compensation (Topic 718). ASU 2016-09 simplifies various aspects of accounting for share-basedpayments and presentation in the financial statements. ASU 2016-09 is effective for annual and interim reporting periods beginning after December 15, 2016and early adoption is permitted. We do not anticipate the adoption to have a material effect on our financial statements.In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). ASU 2016-02 requires management to record right-to-use asset and leaseliability on the statement of financial position for operating leases. ASU 2016-02 is effective for annual and interim reporting periods beginning on or afterDecember 15, 2018 and modified retrospective approach is required. Adoption of this new standard is not expected to have a material impact on theCompany’s consolidated financial statements. 99Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) In January 2016, the FASB issued ASU 2016-01, Financial instruments (Subtopic 825-10). ASU 2016-01 requires management to measure equityinvestments at fair value with changes in fair value recognized in net income. ASU 2016-01 is effective for annual and interim reporting periods beginningon or after December 15, 2017 and early adoption is not permitted. The Company does not expect the adoption of ASU 2016-01 to have a material effectupon its financial statements or disclosures.In August 2014, the FASB issued ASU 2014-15, Presentation of Financial Statements — Going Concern (Subtopic 205-40): Disclosure ofUncertainties about an Entity’s Ability to Continue as a Going Concern. ASU 2014-15 requires management to assess an entity’s ability to continue as agoing concern, and to provide related footnote disclosures in certain circumstances. ASU 2014-15 is effective for annual and interim reporting periodsbeginning on or after December 15, 2016 and early adoption is permitted. The Company adopted this new standard for the year ended December 31, 2016,and adoption did not have a material impact on the Company’s consolidated financial statements. In June 2014, the FASB issued ASU 2014-12, StockCompensation (Topic 718) an amendment to its accounting guidance related to stock-based compensation. The amendment requires that a performancetarget that could be achieved after the requisite service period be treated as a performance condition that affects vesting, rather than a condition that affectsthe grant-date fair value. ASU 2014-12 is effective for annual and interim periods beginning after December 15, 2015. Early adoption is permitted. Theamendment can be applied on a prospective basis to all share-based payments granted or modified on or after the effective date. Entities will also be providedan option to apply the guidance on a modified retrospective basis to existing awards. The Company adopted this new standard for the year endedDecember 31, 2016, and adoption did not have a material impact on the Company’s consolidated financial statements.In May 2014, the FASB issued ASU 2014-09, Revenue from Contracts with Customers (Topic 606), which requires an entity to recognize the amount ofrevenue to which it expects to be entitled for the transfer of promised goods or services to customers. The ASU will replace most existing revenue recognitionguidance in U.S. GAAP when it becomes effective. In March 2016, the FASB amended the principal-versus-agent implementation guidance and illustrationsin the new standard. In April 2016, the FASB amended the guidance on identifying performance obligations and the implementation guidance on licensingin the new standard. In May 2016, the FASB amended the guidance on collectability, noncash consideration, presentation of sales tax and transition in thenew standard. In December 2016, the FASB issued ASU No. 2016-20, Technical Corrections and Improvements to Topic 606, Revenue from Contracts withCustomers, which amends certain narrow aspects of the guidance issued in ASU 2014-09. The new standard will become effective starting on January 1, 2018.Early application is permitted to the original effective date of January 1, 2017. The Company will adopt the standard on January 1, 2018. The standardpermits the use of either the modified retrospective method or full retrospective approach for all periods presented. While the Company is continuing toassess all potential impacts of the standard, the Company believes the most significant accounting impact will relate to the timing of the recognition of ourlicense, collaboration, and milestone revenues. 100Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Note 2 — Net Income (Loss) Per ShareBasic net income (loss) per share is computed by dividing net income (loss) by the weighted average number of vested common shares outstandingduring the period. Diluted net income (loss) per share is computed by giving effect to all potentially dilutive common shares, including outstanding stockoptions, unvested restricted stock, warrants, convertible preferred stock and shares issuable under the Company’s Employee Stock Purchase Plan (“ESPP”), byapplying the treasury stock method. The following is the calculation of basic and diluted net income (loss) per share (in thousands, except per share data): Years Ended December 31, 2016 2015 2014 Net income (loss) $16,453 $(37,501) $(14,646) Weighted-average shares used in computing net income (loss) per share — basic 39,943 38,814 35,709 Effect of dilutive securities: Warrants to purchase common stock 2,019 — — Options to purchase common stock 409 — — Restricted stock units 181 — — Shares issuable related to the ESPP 9 — — Dilutive potential common shares 2,618 — — Weighted-average shares used in computing net income (loss) per share — diluted 42,561 38,814 35,709 Net income (loss) per share — basic $0.41 $(0.97) $(0.41) Net income (loss) per share — diluted $0.39 $(0.97) $(0.41) The following instruments were excluded from the computation of diluted net income (loss) per share for the periods presented because their effectwould have been antidilutive (in thousands): December 31, 2016 2015 2014 Options to purchase common stock 3,688 4,835 3,298 Warrants to purchase common stock — 5,641 6,691 Restricted and Performance stock units — 757 63 Shares issuable related to the ESPP — 16 15 Total shares 3,688 11,249 10,067 Note 3 — Supplementary Cash Flow DataSupplemental cash flow information was as follows (in thousands): Years EndedDecember 31, 2016 2015 2014 Cash paid for interest $1,899 $94 $— Cash paid for income taxes 1 1 1 Significant non-cash investing and financing activities: Debt discount netted against proceeds from long term debt, recorded in equity 288 282 — Interest paid on the long-term debt, at inception 63 41 — Purchases of property and equipment through accounts payable (320) (147) 170 Purchases of property and equipment through accrued liabilities (747) (2) 27 101Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Note 4 — Cash Equivalents and InvestmentsCash Equivalents and Available for Sale InvestmentsThe amortized cost and fair value of cash equivalents and available for sale investments at December 31, 2016 and 2015 were as follows (inthousands): December 31, 2016 AmortizedCost UnrealizedGains UnrealizedLosses FairValue MaturityDates Cash equivalents — U. S. Treasury securities and money market funds $55,658 $— $— $55,658 Short-term investments — U.S. Treasury securities $89,396 $2 $(23) $89,375 1/2017 — 12/2017 Long-term investments — Equity and U.S. Treasury securities $7,513 $176 $(17) $7,672 2/2018 — 3/2018 December 31, 2015 AmortizedCost UnrealizedGains UnrealizedLosses FairValue MaturityDates Cash equivalents — money market funds $63,136 $— $— $63,136 Short-term investments — U.S. Treasury securities $46,395 $1 $(30) $46,366 2/2016 —8/2016 Long-term investments — equity securities $— $179 $— $179 As of December 31, 2016 and December 31, 2015, the Company’s U.S. Treasury securities classified as short-term investments had unrealized losses ofapproximately $23,000 and $30,000, respectively. The net unrealized loss at December 31, 2016 and December 31, 2015 was primarily caused by increasesin short-term interest rates subsequent to the purchase dates of the related securities. At December 31, 2016 there were no investments that had been in acontinuous unrealized loss position for 12 months or longer. The Company collected the contractual cash flows on its U.S. Treasury securities that maturedfrom January 1, 2017 through February 23, 2017 and expects to be able to collect all contractual cash flows on the remaining maturities of its U.S. Treasurysecurities.Interest income was as follows (in thousands): Years EndedDecember 31, 2016 2015 2014 Interest income $449 $156 $101 Note 5 — Fair Value MeasurementsThe Company follows the fair value accounting guidance to value its financial assets and liabilities. Fair value is defined as the price that would bereceived for assets when sold or paid to transfer a liability in an orderly transaction between market participants at the measurement date (exit price). TheCompany utilizes market data or assumptions that the Company believes market participants would use in pricing the asset or liability, includingassumptions about risk and the risks inherent in the inputs to the valuation technique. These inputs can be readily observable, market corroborated orgenerally unobservable.The Company primarily applies the market approach for recurring fair value measurements and endeavors to utilize the best information reasonablyavailable. Accordingly, the Company utilizes valuation techniques that 102Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible, and considers the security issuers’ and the third-party insurers’ credit risk in its assessment of fair value.The Company classifies the determined fair value based on the observability of those inputs. Fair value accounting guidance establishes a fair valuehierarchy that prioritizes the inputs used to measure fair value. The hierarchy gives the highest priority to unadjusted quoted prices in active markets foridentical assets or liabilities (Level 1 measurement) and the lowest priority to unobservable inputs (Level 3 measurement). The three defined levels of the fairvalue hierarchy are as follows:Level 1 — Observable inputs, such as quoted prices in active markets for identical assets or liabilities;Level 2 — Inputs, other than the quoted prices in active markets, that are observable either directly or through corroboration with observable marketdata; andLevel 3 — Unobservable inputs, for which there is little or no market data for the assets or liabilities, such as internally-developed valuation models.Financial assets measured at fair value on a recurring basis as of December 31, 2016 and 2015 are classified in the table below in one of the threecategories described above (in thousands): December 31, 2016 Fair Value Measurements Using AssetsAt Fair Value Level 1 Level 2 Level 3 Assets: Money market funds $52,657 $— $— $52,657 U.S. Treasury securities 99,872 — — 99,872 Equity securities 176 — — 176 Total $152,705 $— $— $152,705 Amounts included in: Cash and cash equivalents $55,658 $— $— $55,658 Short-term investments 89,375 — — 89,375 Long-term investments 7,672 — — 7,672 Total $152,705 $— $— $152,705 December 31, 2015 Fair Value Measurements Using AssetsAt Fair Value Level 1 Level 2 Level 3 Assets: Money market funds $63,136 $— $— $63,136 U.S. Treasury securities 46,366 — — 46,366 Equity securities 179 — — 179 Total $109,681 $— $— $109,681 Amounts included in: Cash and cash equivalents $63,136 $— $— $63,136 Short-term investments 46,366 — — 46,366 Long-term investments 179 — — 179 Total $109,681 $— $— $109,681 103Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) The valuation technique used to measure fair value for the Company’s Level 1 assets is a market approach, using prices and other relevant informationgenerated by market transactions involving identical assets. As of December 31, 2016 and 2015, the Company had no financial assets measured at fair valueon a recurring basis using significant Level 2 or Level 3 inputs. The carrying amount of the Company’s accounts receivable and accounts payableapproximates fair value due to the short-term nature of these instruments.Long Term Debt:As of December 31, 2016 and December 31, 2015, the fair value of the long-term debt, payable in installments through year ended 2020, approximatedits carrying value of $29.9 million and $14.6 million, respectively, because it is carried at a market observable interest rate, which are considered Level 2.Note 6 — Balance Sheet ComponentsProperty and equipment balances were as follows (in thousands): December 31, 2016 2015 Property and equipment, net: Laboratory equipment $16,742 $15,713 Computer equipment and software 2,699 2,510 Office equipment, furniture and fixtures 856 945 Leasehold improvements 4,458 3,425 Total property and equipment 24,755 22,593 Less: Accumulated depreciation and amortization (21,118) (20,842) Total property and equipment, net $3,637 $1,751 Depreciation expense was $0.7 million, $0.6 million and $0.5 million for the years ended December 31, 2016, 2015 and 2014 respectively.Accrued liabilities were as follows (in thousands): December 31, 2016 2015 Accrued liabilities: Clinical and preclinical costs $10,092 $3,446 Bonus 3,800 2,720 Other payroll related 1,888 1,464 Other accrued expenses 1,595 791 Leasehold improvements 672 — Total accrued liabilities $18,047 $8,421 Interest receivable on cash equivalents and investments of $0.2 million and $0.2 million is included in prepaid and other current assets atDecember 31, 2016 and 2015, respectively.The Company sponsors a 401(k) defined contribution plan covering all employees. In 2016, 2015 and 2014, employer contributions to the 401(k) planwere $0.5 million, $0.4 million and $0.3 million, respectively. 104Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Note 7 — Related Parties and Related Party TransactionsResearch and Development ArrangementsAmgen Inc. (“Amgen”)In December 2006, the Company entered into a collaboration and option agreement with Amgen to discover, develop and commercialize novel smallmolecule therapeutics, including omecamtiv mecarbil, that activate cardiac muscle contractility for potential applications in the treatment of heart failure(the “Amgen Agreement”). The agreement granted Amgen an option to obtain an exclusive license worldwide, except Japan, to develop and commercializeomecamtiv mecarbil and other drug candidates arising from the collaboration. In May 2009, Amgen exercised its option. As a result, Amgen becameresponsible for the development and commercialization of omecamtiv mecarbil and related compounds at its expense worldwide (excluding Japan), subjectto the Company’s development and commercialization participation rights. Amgen reimburses the Company for certain research and development activitiesit performs under the collaboration.In June 2013, Cytokinetics and Amgen executed an amendment to the Amgen Agreement to include Japan, resulting in a worldwide collaboration (the“Amgen Agreement Amendment”). Under the terms of the Amgen Agreement Amendment, the Company received a non-refundable upfront license fee of$15.0 million in June 2013. Under the Amgen Agreement Amendment, the Company conducted a Phase 1 pharmacokinetic study intended to supportinclusion of Japan in a potential Phase 3 clinical development program and potential global registration dossier for omecamtiv mecarbil. Amgen reimbursedthe Company for the costs of this study. In addition, the Company is eligible to receive additional pre-commercialization milestone payments relating to thedevelopment of omecamtiv mecarbil and royalties on sales of omecamtiv mecarbil in Japan.In conjunction with the Amgen Agreement Amendment, the Company also entered into a common stock purchase agreement which provided for thesale of 1,404,100 shares of its common stock to Amgen at a price per share of $7.12 and an aggregate purchase price of $10.0 million, which was received inJune 2013. The Company determined the fair value of the stock issued to Amgen to be $7.5 million. The excess of cash received over fair value of$2.5 million was initially deferred and allocated between the license and services based on their relative selling prices using best estimate of selling price.The allocated consideration was recognized as revenue as revenue criteria were satisfied, or as services were performed over approximately 12 months.Pursuant to this agreement, Amgen agreed to certain trading and other restrictions with respect to the Company’s common stock.The Company determined that the license to the Japan territory granted under the Amgen Agreement Amendment was a separate, non-contingentdeliverable under the amendment. The Company determined that the license has stand-alone value based on Amgen’s internal product developmentcapabilities since all relevant manufacturing know-how related to omecamtiv mecarbil was previously delivered to Amgen.In October 2013, the Company determined that the revenue recognition requirements under ASC 605-10 had been met and accordingly, recognized$17.2 million in license revenue attributable to the Amgen Agreement Amendment in the fourth quarter of 2013. In year ended December 31, 2014, theCompany recognized the remaining $0.3 million of the previously deferred consideration attributable to the Amgen Agreement Amendment as research anddevelopment revenues from related parties.Amgen and the Company continued the research program in 2016. Under the amended Amgen Agreement, the Company is entitled to receivereimbursements of internal costs of certain full-time employee equivalents during 2016, as well as potential additional milestone payments related to theresearch activities.Under the Amgen Agreement, as amended, the Company is eligible to receive over $300.0 million in additional development milestone paymentswhich are based on various clinical milestones, including the 105Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) initiation of certain clinical studies, the submission of a drug candidate to certain regulatory authorities for marketing approval and the receipt of suchapprovals. Additionally, the Company is eligible to receive up to $300.0 million in commercial milestone payments provided certain sales targets are met.Due to the nature of drug development, including the inherent risk of development and approval of drug candidates by regulatory authorities, it is notpossible to estimate if and when these milestone payments would become due. The achievement of each of these milestones is dependent solely upon theresults of Amgen’s development and commercialization activities.During the year ended December 31, 2016, the Company recognized $26.7 million in development milestone payments related to the start ofGALACTIC-HF, the Phase 3 cardiovascular outcomes clinical trial of omecamtiv mecarbil which is being conducted by Amgen as the Company has noremaining deliverables under the Amgen Agreement. During the years ended December 31, 2015 and 2014, no milestones were achieved under the AmgenAgreement.The Amgen Agreement also provides for the Company to receive increased royalties by co-funding Phase 3 development costs of omecamtiv mecarbiland other drug candidates under the collaboration. If the Company elects to co-fund such costs at the $40.0 million level, it would be entitled to co-promotethe co-funded drug in North America and participate in agreed commercialization activities in institutional care settings, at Amgen’s expense.In July 2013, Amgen announced that it had granted an option to commercialize omecamtiv mecarbil in Europe to Servier, with the Company’s consent,pursuant to an Option, License and Collaboration Agreement (the “Servier Agreement”).In August 2016, the Company entered into a Letter Agreement with Amgen and Servier (the “Letter Agreement”), which (i) expands the territory of thesublicense to Servier to include specified countries in the Commonwealth of Independent States (“CIS”) and (ii) provides that, if Amgen’s rights under theAmgen Agreement, as amended, are terminated with respect to the territory of such sublicense, the sublicensed rights previously granted by Amgen to Servierunder the Servier Agreement will remain in effect and become a direct license or sublicense of such rights by us to Servier, on substantially the same terms asset forth in the Servier Agreement, including but not limited to Servier’s payment of its share of agreed development costs and future milestone and royaltypayments to us. The Letter Agreement does not otherwise modify our rights and obligations under the Amgen Agreement, as amended, or create anyadditional financial obligations of the Company, unless we otherwise agree in writing.In September 2016, Amgen and Servier announced Servier’s decision to exercise its option to commercialize omecamtiv mecarbil in Europe as well asthe CIS, including Russia. The option and related commercialization sublicense to Servier is subject to the terms and conditions of the Amgen Agreement.Amgen remains responsible for the performance of its obligations under the Amgen Agreement relating to Europe and the CIS, including the payment ofmilestones and royalties relating to the development and commercialization of omecamtiv mecarbil in Europe and the CIS.In December 2016, the Company provided notice of its exercise of its option under the Amgen Agreement to co-invest in the Phase 3 developmentprogram of omecamtiv mecarbil at the level of $10.0 million in exchange for an incremental royalty from Amgen of up to 1% on increasing worldwide salesof omecamtiv mecarbil outside Japan. The payment of $10.0 million is due to Amgen in eight quarterly installments with the first payment due at the time ofproviding notice of the option exercise and is contingent on Amgen continuing the Phase 3 development program of omecamtiv mecarbil. As ofDecember 31, 2016, the Company recorded a payment of $1.3 million as a reduction in collaboration revenue, related to the option to co-invest in thePhase 3 development program of omecamtiv mecarbil, as it concluded the benefit to be received in exchange for the 106Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) co-investment payment to Amgen, was not sufficiently separable from Amgen Agreement. In February 2017, the Company provided notice of its furtherexercise of its co-invest option in the additional amount of $30.0 million (i.e. to fully co-invest $40.0 million) in the Phase 3 development program ofomecamtiv mecarbil. See Note 15 — “Subsequent Events” in the Notes to Consolidated Financial Statements for additional information.Pursuant to the Amgen Agreement, the Company has recognized research and development revenue from Amgen for reimbursements of internal costsof certain full-time employee equivalents, supporting a collaborative research program directed to the discovery of next-generation cardiac sarcomereactivator compounds and of other costs related to that research program. These reimbursements were recorded as research and development revenues fromrelated parties. During the years ended December 31, 2016, 2015 and 2014, the Company recorded net research and development revenue from Amgen of$27.9 million, $2.5 million and $4.5 million, respectively, under the Amgen Agreement. There were no accounts receivable due from Amgen during the yearsended December 31, 2016 and 2015.Revenue from Amgen was as follows (in thousands): Years Ended December 31, 2016 2015 2014 Research and development revenues from related parties, net: Reimbursement of internal costs $2,466 $2,460 $4,260 Research and development milestone fees 26,666 — — Co-invest option payment (1,250) — — Allocated consideration — 21 278 Total Research and development revenues from related parties, net 27,882 2,481 4,538 Total net revenues from Amgen $27,882 $2,481 $4,538 There were no accounts receivable due from Amgen at December 31, 2016 and 2015.Astellas Pharma Inc. (“Astellas”)Original Astellas Agreement (Non-neuromuscular license)In June 2013, the Company entered into a license and collaboration agreement with Astellas (the “Original Astellas Agreement”). The primaryobjective of the collaboration with Astellas is to advance novel therapies for diseases and medical conditions associated with muscle weakness.Under the Original Astellas Agreement, the Company granted Astellas an exclusive license to co-develop and jointly commercialize CK-2127107, afast skeletal troponin activator, for potential application in non-neuromuscular indications worldwide. The Company was primarily responsible for theconduct of Phase 1 clinical trials and certain Phase 2 readiness activities for CK-2127107 and Astellas was primarily responsible for the conduct ofsubsequent development and commercialization activities for CK-2127107.In July 2013, the Company received an upfront, non-refundable license fee of $16.0 million in connection with the execution of the Original AstellasAgreement. Under the agreement, the Company was eligible to potentially receive over $24.0 million in reimbursement of sponsored research anddevelopment activities during the initial two years of the collaboration. The Original Astellas Agreement also provided for research and early and late stagedevelopment milestone payments based on various research and clinical milestones, including the initiation of certain clinical studies, the submission forapproval of a drug candidate to certain regulatory authorities for marketing approval and the commercial launch of collaboration products, and royalties onsales of commercialized products. 107Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) At the inception of the Original Astellas Agreement, the Company deferred revenue related to the Original Astellas Agreement in accordance with ASC605-25. The Company evaluated whether the delivered elements under the arrangement have value on a stand-alone basis. Upfront, non-refundable licensingpayments are assessed to determine whether or not the licensee is able to obtain stand-alone value from the license. Where this is not the case, the Companydoes not consider the license deliverable to be a separate unit of accounting, and the revenue for the license fee is deferred and recognized in conjunctionwith the other deliverables that constitute the combined unit of accounting.The Company determined that the license and the research and development services are a single unit of accounting as the license was determined tonot have stand-alone value. Accordingly, the Company is recognizing this revenue using the proportional performance model over the initial research term ofthe Original Astellas Agreement. During the years ended December 31, 2016, 2015 and 2014, the Company recorded zero, $2.3 million and $9.8 million,respectively, in license revenue based on the proportional performance model under the Original Astellas Agreement. No license revenue remains deferredunder the Original Astellas Agreement as of December 31, 2016.Pursuant to the Original Astellas Agreement, the Company recognized research and development revenue from Astellas for reimbursements of internalcosts of certain full-time employee equivalents, supporting collaborative research and development programs, and of other costs related to those programs.During the years ended December 31, 2016, 2015 and 2014, the Company recorded research and development revenue from Astellas of zero, $3.5 million and$15.4 million, respectively, under the Original Astellas Agreement.2014 Astellas Agreement (Expansion to include neuromuscular indications)In December 2014, the Company entered into an amended and restated license and collaboration agreement with Astellas (the “2014 AstellasAgreement”). This agreement superseded the Original Astellas Agreement. The 2014 Astellas Agreement expanded the objective of the collaboration ofadvancing novel therapies for diseases and medical conditions associated with muscle weakness to include spinal muscular atrophy (“SMA”) and potentiallyother neuromuscular indications for CK-2127107 and other fast skeletal troponin activators, in addition to the non-neuromuscular indications provided for inthe Original Astellas Agreement.Under the 2014 Astellas Agreement, the Company received a non-refundable upfront license fee of $30.0 million in January 2015. Concurrently, theCompany received $15.0 million as a milestone payment relating to Astellas’ decision to advance CK-2127107 into Phase 2 clinical development. Under the2014 Astellas Agreement, the Company is conducting the initial Phase 2 clinical trial of CK-2127107 in patients with SMA.The Company determined that the license and the research and development services relating to the 2014 Astellas Agreement are a single unit ofaccounting as the license was determined to not have stand-alone value. Accordingly, the Company is recognizing this revenue over the research term of the2014 Astellas Agreement using the proportional performance model.During the years ended December 31, 2016 and 2015, the Company recorded $12.1 million and $11.6 million, respectively, in license revenue basedon the proportional performance model under the 2014 Astellas Agreement. No such revenues were recognized during the year ended December 31, 2014. Asof December 31, 2016, $7.2 million license revenue remains deferred under the 2014 Astellas Agreement. Pursuant to the 2014 Astellas Agreement, theCompany recognized research and development revenue from Astellas for reimbursements of internal costs of certain full-time employee equivalents,supporting collaborative research and development programs, and of other costs related to those programs. The Company was eligible to potentially 108Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) receive over $20.0 million in reimbursement of sponsored research and development activities during the two years of the collaboration following theexecution of the 2014 Astellas Agreement. During the years ended December 31, 2016 and 2015, the Company recorded research and development revenuefrom Astellas of $13.0 million and $8.7 million, respectively, under the 2014 Astellas Agreement. No such revenues were recognized during the year endedDecember 31, 2014.In conjunction with the 2014 Astellas Agreement, the Company also entered into a common stock purchase agreement which provided for the sale of2,040,816 shares of its common stock to Astellas at a price per share of $4.90 and an aggregate purchase price of $10.0 million which was received inDecember 2014. Pursuant to this agreement, Astellas agreed to certain trading and other restrictions with respect to the Company’s common stock. TheCompany determined the fair value of the stock issued to Astellas to be $9.1 million. The excess of cash received over fair value of $0.9 million was deferredalong with the license and research and development services. Allocated consideration will be recognized as revenue for the single unit of accounting above,as services are performed following the proportional performance model over the research term of the 2014 Astellas Agreement. Following the common stockpurchase, Astellas was determined to be a related party. As such, all revenue earned following the common stock purchase is classified as related partyrevenue.2016 Astellas Amendment (Inclusion of ALS as an Added Indication and Option on Tirasemtiv)In 2016, Cytokinetics and Astellas further amended the collaboration agreement to expand our collaboration to include the development ofCK-2127107 for the potential treatment of ALS (“2016 Astellas Amendment”), as well as the possible development in ALS of other fast skeletal regulatoryactivators previously licensed by us to Astellas. The 2016 Astellas Amendment became effective in September 2016 (collectively with the 2014 AstellasAgreement, the “Current Astellas Agreement”).Under the 2016 Astellas Amendment, the Company granted Astellas the Option on Tirasemtiv. If Astellas exercises the option, Astellas will receiveexclusive worldwide commercialization rights outside of the Company’s commercialization territory of North America, Europe and other select countries.Tirasemtiv is the Company’s fast skeletal troponin activator being evaluated in the ongoing Phase 3 clinical trial, VITALITY-ALS, in people living withamyotrophic lateral sclerosis (“ALS”).In addition, the 2016 Astellas Amendment expands the Company’s collaboration with Astellas to include the development of CK-2127107, a next-generation fast skeletal troponin activator, for the potential treatment of ALS, as well the possible development in ALS of other fast skeletal regulatoryactivators licensed to Astellas under the 2014 Astellas Agreement (“ALS License”). Finally, the 2016 Astellas Amendment extends the existing joint researchprogram focused on the discovery of additional next-generation skeletal muscle activators through 2017, including sponsored research at Cytokinetics.Astellas’ Option on TirasemtivIn connection with the execution of the 2016 Astellas Amendment, the Company received a $15.0 million non-refundable option fee for the grant ofthe Option on Tirasemtiv in October 2016. Prior to Astellas’ exercise of the option, the Company will continue the development of tirasemtiv, including theVITALITY-ALS trial, at its own expense to support regulatory approval in the U.S., EU and certain other jurisdictions and will retain the final decisionmaking authority on the development of tirasemtiv. If Astellas exercises the option, the Company will grant Astellas an exclusive license to develop andcommercialize tirasemtiv outside the Company’s own commercialization territory of North America, Europe and other select countries (“License ontirasemtiv”) under a tirasemtiv License and Collaboration Agreement (“tirasemtiv License Agreement”). Each party would be 109Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) primarily responsible for the further development of tirasemtiv in its territory and have the exclusive right to commercialize tirasemtiv in its territory.If Astellas exercises its option for a global collaboration for the development and commercialization of tirasemtiv, the Company will receive an optionexercise payment ranging from $25.0 million (if exercise occurs following receipt of data from the VITALITY-ALS trial) to $80.0 million (if exercise occursfollowing receipt of FDA approval) and a milestone payment of $30.0 million from Astellas associated with the Company’s initiation of the open-labelextension trial for tirasemtiv (VIGOR-ALS). The Company will be responsible for the development costs of tirasemtiv during the option period, but if Astellasexercises the option after the defined review period following receipt of data from VITALITY-ALS, Astellas will at the time of option exercise reimburse theCompany for a share of any additional costs incurred after such review period.If Astellas exercises the option for tirasemtiv, the parties will share the future development costs of tirasemtiv in North America, Europe and certainother countries (with Cytokinetics bearing 75% of such shared costs and Astellas bearing 25% of such costs), and Astellas will be solely responsible for thedevelopment costs of tirasemtiv specific to its commercialization territory. Contingent upon the successful development of tirasemtiv, the Company mayreceive milestone payments up to $100.0 million for the initial indication and up to $50.0 million for each subsequent indication. If tirasemtiv iscommercialized, Astellas will pay the Company royalties (at rates ranging from the mid-teens to twenty percent) on sales of tirasemtiv in Astellas’ territory,and the Company will pay Astellas royalties (at rates up to the mid-teens) on sales of tirasemtiv in the Company’s territory, in each case subject to variouspossible adjustments.The Company concluded that the option to obtain the License on Tirasemtiv is a substantive option, and is therefore not considered a deliverable atthe execution of the 2016 Astellas Amendment. The Company determined that the Tirasemtiv License Agreement is contingent upon the exercise of theOption on Tirasemtiv, and is therefore not effective during the periods presented, since the option has not been exercised as of the latest balance sheet date. Inaddition, the Company did evaluate the consideration set to be received for the License on Tirasemtiv in relation to the fair value of the License ontirasemtiv, and determined that it was not being provided at a significant incremental discount.The Company further determined that the Option Fee of $15.0 million was deemed to be a prepayment towards the License on tirasemtiv, and thereforedeferred revenue recognition either until the option is exercised, or until the option expires unexercised. If the Option on Tirasemtiv expires unexercised, the$15.0 million received would be added to the 2016 Astellas Amendment consideration, to be allocated to the units of accounting. The Option on Tirasemtivexpires, if not exercised by Astellas, following the receipt of the approval letter for tirasemtiv from the FDA.Prior to Astellas’ exercise of the option, the Company will continue the development of tirasemtiv, including the VITALITY-ALS trial, at its ownexpense to support regulatory approval in the U.S., EU and certain other jurisdictions, and the Company has complete discretion to continue to conductclinical trials, and will retain the final decision making authority on the development of tirasemtiv. Therefore, the Company concluded that there was noobligation related to any development services during the option period.Addition of ALS as an Added Indication (CK-2127107 and other fast skeletal activators)In connection with the execution of the 2016 Astellas Amendment, the Company received a non-refundable upfront amendment fee of $35 million. Inaddition, the Company received an accelerated $15.0 million milestone payment that would have been payable upon the initiation of the first Phase 2clinical trial of CK-2127107 as the lead compound in ALS, as if such milestone had been achieved upon the execution of the 2016 Astellas Amendment. 110Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) The Company and Astellas are collaborating to develop CK-2127107 in ALS. Astellas is primarily responsible for the development of CK-2127107 inALS, but the Company will conduct the Phase 2 clinical trial of CK-2127107 in ALS and will share in the operational responsibility for later clinical trials.Subject to specified guiding principles, decision making will be by consensus, subject to escalation and, if necessary, Astellas’ final decision makingauthority on the development (including regulatory affairs), manufacturing, medical affairs and commercialization of CK-2127107 and other fast skeletalregulatory activators in ALS. The Company and Astellas will share equally the costs of developing CK-2127107 in ALS for potential registration andmarketing authorization in the U.S. and Europe, provided that (i) Astellas has agreed to solely fund Phase 2 development costs of CK-2127107 in ALSsubject to a right to recoup the Company’s share of such costs plus a 100% premium by reducing future milestone and royalty payments to the Company and(ii) the Company may defer (but not eliminate) a portion of its co-funding obligation for development activities after Phase 2 for up to 18 months, subject tocertain conditions. The Company has the right to co-fund its share of such Phase 2 development costs on a current basis, in which case there would not be apremium due to Astellas. Cytokinetics will also receive approximately $41.8 million in additional sponsored research and development funding through2018 which includes Astellas’ funding of Cytokinetics’ conduct of the Phase 2 clinical development of CK-2127107 in ALS (approximately $36.6 million)as well as the continuing research collaboration (approximately $5.2 million).Pursuant to the 2016 Astellas Amendment, the Company and Astellas will collaborate to develop CK-2127107 in ALS. Astellas will be primarilyresponsible for the development of CK-2127107 in ALS, but the Company will conduct the Phase 2 clinical trial of CK-2127107 in ALS and will share in theoperational responsibility for later clinical trials. Subject to specified guiding principles, decision making will be by consensus, subject to escalation and, ifnecessary, Astellas’ final decision making authority on the development (including regulatory affairs), manufacturing, medical affairs and commercializationof CK-2127107 and other fast skeletal regulatory activators in ALS.The Company determined that the deliverables under the 2016 Astellas Amendment included (1) the ALS License, (2) CK-2127107 developmentservices in ALS through Phase 2 activities (“ALS Development Services”), and (3) research services added (“Additional Research Services”). Deliverablesthat do not provide standalone value have been combined with other deliverables to form a unit of accounting that collectively has standalone value, withrevenue being recognized on the combined unit of accounting, rather than the individual deliverables. There are no rights of return provisions for thedelivered items in the Current Astellas Agreement.The Company considered the 2016 Astellas Amendment to be a modification of the 2014 Astellas Agreement. The remaining deliverables under the2014 Astellas Agreement are: (1) the SMA license; (2) Research Services in connection with the Research Plan (through 2016); and (3) SMA DevelopmentServices in connection with the Development Plan. The Company evaluated the components and consideration of the 2016 Astellas Amendment againstother Phase 2 collaboration arrangements, and determined that the new 2016 deliverables had standalone value and are delivered at fair value. Therefore noreallocation of consideration to the 2014 deliverables was performed.The Company concluded that there are two units of accounting; the ALS License, and the Additional Research Services and ALS DevelopmentServices (“Research and ALS Development Services”). The Company also determined that the ALS License has standalone value since (1) Astellas received aworldwide license for ALS, to perform further research in the field of ALS, to develop and use CK-2127107 to make, have make, sell or otherwisecommercialize CK-2127107 in ALS; (2) Astellas has the right to sublicense the rights to CK-2127107 in ALS to a third party; and (3) Astellas has thetechnical capabilities to advance further development on CK-2127107 in ALS, without the continued involvement of the Company. 111Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Arrangement Consideration under the 2016 Astellas Amendment related to CK-2127107 and research is comprised of the following (in millions): ArrangementConsideration Amendment Fee $35.0 Accelerated milestone payment 15.0 Total Upfront Consideration 50.0 Additional Research Services 5.1 ALS Development Services 39.1 Total Committed Consideration 44.2 Total Consideration $94.2 The Company allocated the $50.0 million in upfront consideration along with the $44.2 million in then committed research and developmentconsideration, among the two units of accounting, on a relative fair value basis, using the best estimated selling price (“BESP”). The BESP of the ALSLicense was determined using a discounted cash flow, risk adjusted for probability of success; while the BESP of the research and development services weredetermined using estimated research and development cost, included in the research and development programs approved by Astellas. Based on thisallocation of consideration, the Company stands to recognize $74.9 million in license revenue and $19.3 in research and development revenue, under the2016 Astellas Amendment. Since the upfront consideration of $50.0 million is less than the allocated consideration of the ALS License, the Companyrecognized $50.0 million in license revenue on the Amendment Effective Date, in September 2016, and record the remaining $24.9 million as an allocationfrom research and development services, when those services are performed.Allocation of arrangement consideration, and revenue recognition (in millions): AllocatedConsideration UpfrontRevenueRecognition RevenueRecognitionoverPerformancePeriod Units of Accounting: ALS License $74.9 $50.0 $24.9 Research and ALS Development Services 19.3 — 19.3 Total consideration $94.2 $50.0 $44.2 During the year ended December 31, 2016, the Company recorded $50.1 million in license revenue under the 2016 Astellas Amendment.The Company will recognize the research and development services using the proportional performance model over the initial development term,through the completion of the ALS Development Services. Pursuant to the 2016 Astellas Amendment, the Company receives payment for research anddevelopment revenue from Astellas for reimbursements of internal costs of certain full-time employee equivalents, supporting collaborative research anddevelopment programs, and of other costs related to those programs.During the year ended December 31, 2016, the Company recorded $0.1 million research and development revenue from Astellas, under the 2016Astellas Amendment. 112Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) The Company believes that each of the milestones related to research under the Current Astellas Agreement is substantive and can only be achievedwith the Company’s past and current performance and each milestone will result in additional payments to the Company. During the year endedDecember 31, 2016, the Company recorded $2.0 million in milestone revenue for research under this agreement, related to the initiation of IND-enablingstudies for a fast skeletal muscle activator. The Company is eligible to receive up to $2.0 million in research milestone payments under the collaboration foreach future potential drug candidate.The achievement of each of the late stage development milestones and the commercialization milestones are dependent solely upon the results ofAstellas’ development activities and therefore these milestones were not deemed to be substantive.Under the Current Astellas Agreement, additional research and early and late state development milestone payments which are based on variousresearch and clinical milestones, including the initiation of certain clinical studies, the submission for approval of a drug candidate to certain regulatoryauthorities for marketing approval and the commercial launch of collaboration products could total over $600.0 million, including up to $95.0 millionrelating to CK-2127107 in non-neuromuscular indications, and over $100.0 million related to CK-2127107 in each of SMA, ALS and other neuromuscularindications. Additionally, $200.0 million in commercial milestones could be received under the Current Astellas Agreement provided certain sales targets aremet. Due to the nature of drug development, including the inherent risk of development and approval of drug candidates by regulatory authorities, it is notpossible to estimate if and when these milestone payments could become due.In the event Astellas commercializes any collaboration products, the Company will receive royalties on sales of such collaboration products, includingroyalties ranging from the high single digits to the high teens on sales of products containing CK-2127107. Cytokinetics can co-fund certain developmentcosts for CK-2127107 and other compounds in exchange for increased milestone payments and royalties; such royalties may increase under certain scenariosto exceed twenty percent. Under the Current Astellas Agreement, Cytokinetics retains an option to co-promote collaboration products containing fast skeletaltroponin activators for neuromuscular indications in the U.S., Canada and Europe, in addition to its option to co-promote other collaboration products in theU.S. and Canada as provided for in the Original Astellas Agreement. Astellas will reimburse Cytokinetics for certain expenses associated with itsco-promotion activities.Research and development revenue from Astellas was as follows (in thousands): Year EndedDecember 31,2016 Year EndedDecember 31,2015 Year EndedDecember 31,2014 License Revenues from Related Parties $62,171 $13,918 $9,835 Research and development revenues with related parties: Reimbursement of internal costs 6,111 6,210 — Reimbursement of other costs 6,999 5,974 — Research and development milestone fees 2,000 — 15,000 Total research and development revenue with related parties from Astellas $15,110 $12,184 $15,000 Research and development revenues: Reimbursement of internal costs — — 8,939 Reimbursement of other costs — — 6,452 Research and development milestone fees — — 2,000 Total research and development revenue from Astellas — — 17,391 Total Revenue from Astellas $77,281 $26,102 $42,226 113Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) At December 31, 2016 and December 31, 2015, the Company had $23.1 million and $20.4 million, respectively, of deferred revenue under the CurrentAstellas Agreement, reflecting the unrecognized portion of the license revenue, option fee and payment of expenses. There were no accounts receivable duefrom Astellas at December 31, 2016 and 2015.Note 8 — Other Research and Development Revenue Arrangements GrantsIn July 2015, The ALS Association (the “ALSA Grant”) awarded to the Company a $1.5 million grant to support the conduct of VITALITY-ALS as wellas the collection of clinical data and plasma samples from patients in VITALITY-ALS in order to help advance the discovery of potentially useful biomarkersin ALS. On August 28, 2015 the Company achieved its first milestone under the ALSA Grant which triggered a payment of $0.5 million in accordance withthe ALSA Grant. The Company recorded $1.1 million and $0.1 million, as grant revenue as qualified expenses were incurred, for years ended December 31,2016 and 2015, respectively. At December 31, 2016, the Company had no deferred revenue under the ALSA Grant, reflecting the unrecognized portion of thegrant revenue.Total grant revenues were as follows (in thousands): Years EndedDecember 31, 2016 2015 2014 ALSA grant revenue $1,084 $75 $— Other grant revenue — — 75 Total grant revenue $1,084 $75 $75 MyoKardia, Inc.In August 2012, the Company entered into a collaboration agreement with MyoKardia, Inc. Under an agreed research plan, scientists from MyoKardiaand our FTEs conduct research focused on small molecule therapeutics that inhibit cardiac sarcomere proteins. The Company provided to MyoKardia accessto certain research facilities, and continues to provide FTEs and other resources at agreed reimbursement rates that approximate our costs. The research planterminated as planned in August 2013. The Company may receive development milestone payments which are based on various clinical milestones.Research and development revenue from MyoKardia was as follows (in thousands): Years Ended December 31, 2016 2015 2014 Research and development milestone fees $150 $— $100 Research and development revenue from Myokardia $150 $— $100 114Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Note 9 — Long-Term DebtLong-term debt and unamortized debt discount balances are as follows (in thousands): December 31, 2016 2015 Notes payable, gross $30,000 $15,000 Less: Unamortized debt discount (472) (389) Accretion of final exit fee 353 28 Carrying value of notes payable 29,881 14,639 Less: Current portion of long-term debt (2,500) — Long-term debt $27,381 $14,639 In October 2015, the Company entered into a loan and security agreement (the “Loan Agreement”) with Oxford Finance LLC (“Oxford,”) as thecollateral agent and a lender, and Silicon Valley Bank (“SVB,”) as a lender (Oxford and SVB collectively the “Lenders”) to fund its working capital and othergeneral corporate needs. The Loan Agreement provided for (1) term loans of up to $40.0 million in aggregate, (2) warrants to purchase 65,189 shares of theCompany’s common stock at an exercise price of $6.90 per share under the first term loan, and (3) additional warrants to purchase shares of the Company’scommon stock to be based on the amount of the additional term loans and a price per share determined on the day of funding in accordance with the GrantAgreement, which is also the exercise price per share for the warrants.The Company drew down $15.0 million in funds under the Loan Agreement in October 2015 at the time of the first draw down, and at that time, couldat its sole discretion draw down an additional $25.0 million under the Loan Agreement in two term loans, provided certain specified conditions stipulated inthe Loan Agreement are met preceding those draws.During February 2016, the Company drew down an additional $15.0 million in funds under the Loan Agreement and issued warrants to purchase68,285 shares of the Company’s common stock at an exercise price of $6.59 per share under the second term loan. As of December 31, 2016, there were133,474 warrants outstanding and exercisable and are classified under stockholder’s equity. In January 2017, the Company issued 33,368 shares of commonstock related to the cashless exercise of 16,126 warrants issued under the Loan Agreement. As of December 31, 2016 the Company received $29.8 millionfrom this loan and security agreement, net of issuance cost. The Company can at its sole discretion draw down an additional $10.0 million under the LoanAgreement from the Lenders, at any time prior to March 31, 2017, subject to the Company’s satisfaction of specified conditions precedent related to theearlier of (i) the occurrence of an equity event as described in the Loan Agreement, or (ii) specified results from the Company’s VITALITY-ALS Phase 3 trialof tirasemtiv, each as specified in the Loan Agreement. The Company is required to repay the outstanding principal in 36 equal installments beginningOctober 2017 and is due in full in in October 2020. The first and second term loans bear interest at a rate of 7.5% per annum, respectively. The remaining termloans, if drawn, will bear interest at a rate fixed at the time of draw, equal to the greater of (i) 7.50% and (ii) the sum of the three month U.S. LIBOR rate plus7.31%. The Company is required to make a final payment fee of 4.00% of the amounts of the Term Loans drawn payable on the earlier of (i) the prepaymentof the Term Loans or (ii) the Maturity Date. The loan carries prepayment penalties of 3% and 2% for prepayment within one and two years, respectively, ofthe loan origination and 1% thereafter. The warrants issued in the Loan Agreement became exercisable upon issuance and will remain exercisable for fiveyears from issuance or the closing of a merger consolidation transaction in which the Company is not the surviving entity.In accordance with the accounting guidance, the Company allocated a portion of the gross proceeds from each draw down under the Loan Agreementto the underlying warrants, using the relative fair value method. This 115Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) resulted in the allocation of $0.6 million of the draw down proceeds to the warrants, which was accounted for as debt discount. Debt discount is beingamortized over the term of the debt, and recorded in interest expense in the statement of operations. The fair value of the warrants was determined using theBlack-Scholes pricing model and are classified as equity.The Loan Agreement contains customary representations and warranties and customary affirmative and negative covenants applicable to the Companyand its subsidiaries, including, among other things, restrictions on dispositions, changes in business, management, ownership or business locations, mergersor acquisitions, indebtedness, encumbrances, distributions, investments, transactions with affiliates and subordinated debt. The Agreement also includescustomary events of default, including but not limited to the nonpayment of principal or interest, violations of covenants, material adverse changes,attachment, levy, restraint on business, cross-defaults on material indebtedness, bankruptcy, material judgments, misrepresentations, subordinated debt,governmental approvals, lien priority and delisting. Upon an event of default, the Lenders may, among other things, accelerate the loans and foreclose on thecollateral. The Company’s obligations under the Agreement are secured by substantially all of the Company’s current and future assets, other than itsintellectual property.The Company recorded interest expense related to the long-term debt of $2.7 million and $0.3 million for the years ended December 31, 2016 and2015, respectively. Included in interest expense for this period was interest on principal, amortization of the debt discount and debt issuance costs, and theaccretion of the final exit fee. For the years ended December 31, 2016 and 2015, the effective interest rate on the amounts borrowed under the Agreement,including the amortization of the debt discount and issuance cost, and the accretion of the final payment, was 9.3%.Future minimum payments under the Loan, as of December 31, 2016 are as follows (in thousands): 2017 $4,768 2018 11,743 2019 10,982 2020 8,938 Total minimum payments 36,431 Less: Interest and final payment (6,431) Notes payable, gross $30,000 Note 10 — Commitments and ContingenciesCommitmentsOperating LeaseThe Company leases office space and equipment under a non-cancelable operating lease that expires in 2018, with an option to extend the lease for anadditional three-year period. The lease terms provide for rental payments on a graduated scale and the Company’s payment of certain operating expenses.During March 2016, the Company amended the lease agreement to include certain additional operating expenses, related to the replacement of two boilers.The Company recognizes rent expense on a straight-line basis over the lease period.Rent expense was as follows (in thousands): Years Ended December 31, 2016 2015 2014 Rent expense $3,448 $3,297 $3,338 116Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) As of December 31, 2016, future minimum lease payments under noncancelable operating leases were as follows (in thousands): 2017 $3,703 2018 1,860 2019 — 2020 — 2021 — Thereafter — Total $5,563 Co-investment optionIn December 2016, the Company has agreed to exercise its option to co-invest $10.0 million in the Phase 3 development program of omecamtivmecarbil under the Amgen Agreement with Amgen. In connection with exercising its co-investment option at $10.0 million, the Company will be eligible toreceive an incremental royalty of up to 1% on increasing worldwide net sales of omecamtiv mecarbil outside of Japan. The payment of $10.0 million is due toAmgen in eight quarterly installments with the first payment due at the time of providing notice of the option exercise and is contingent on Amgencontinuing the Phase 3 development program of omecamtiv mecarbil.As of December 31, 2016, future minimum payments due to Amgen were as follows (in thousands): 2017 $5,000 2018 3,750 Total $8,750 In February 2017, the Company provided notice of its further exercise of its co-invest option in the additional amount of $30.0 million (i.e. to fullyco-invest $40.0 million) in the Phase 3 development program of omecamtiv mecarbil. See Note 15 – “Subsequent Events.”ContingenciesIn the ordinary course of business, the Company may provide indemnifications of varying scope and terms to vendors, lessors, business partners andother parties with respect to certain matters, including, but not limited to, losses arising out of the Company’s breach of such agreements, services to beprovided by or on behalf of the Company, or from intellectual property infringement claims made by third parties. In addition, the Company has entered intoindemnification agreements with its directors and certain of its officers and employees that will require the Company, among other things, to indemnify themagainst certain liabilities that may arise by reason of their status or service as directors, officers or employees. The Company maintains director and officerinsurance, which may cover certain liabilities arising from its obligation to indemnify its directors and certain of its officers and employees, and formerofficers and directors in certain circumstances. The Company maintains product liability insurance and comprehensive general liability insurance, which maycover certain liabilities arising from its indemnification obligations. It is not possible to determine the maximum potential amount of exposure under theseindemnification obligations due to the limited history of prior indemnification claims and the unique facts and circumstances involved in each particularindemnification obligation. Such indemnification 117Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) obligations may not be subject to maximum loss clauses. Management is not currently aware of any matters that could have a material adverse effect on thefinancial position, results of operations or cash flows of the Company.In December 2014, the Company filed a lawsuit alleging fraudulent inducement, breach of contract and negligence on the part of a contract researchorganization for BENEFIT-ALS. The Company was seeking monetary damages. On June 7, 2016 the Company entered into a settlement agreement with thecontract research organization for $4.5 million. The Company received payment related to the settlement agreement in July 2016 and the full settlementamount was classified as a reduction of R&D expense in June 2016.Note 11 — Stockholders’ EquityPreferred StockAs of December 31, 2016 and 2015, respectively, there were 10,000,000 shares of preferred stock authorized and no shares outstanding.Common StockAs of December 31, 2016 and 2015, respectively, there were 163,000,000 shares and 81,500,000 shares of common stock authorized and 40,646,595and 39,581,692 shares outstanding.Accumulated Other Comprehensive Income (Loss)Comprehensive income (loss) is comprised of net income (loss) and other comprehensive income (loss). Other comprehensive income (loss) iscomprised of unrealized holding gains and losses on the Company’s available-for-sale securities that are excluded from net loss and reported separately instockholders’ equity.In 2016 and 2015, the Company recorded insignificant amounts of unrealized gains (losses) in available-for-sale securities in accumulated othercomprehensive loss.Common Stock OutstandingIn June 2011, the Company entered into an At-The-Market Issuance Sales Agreement (the “MLV Agreement”) with McNicoll, Lewis & Vlak LLC(“MLV”), pursuant to which the Company sold, through December 31, 2014, 2,397,278 shares of common stock through MLV for net proceeds ofapproximately $15.2 million.On June 25, 2012, pursuant to the June 2012 Public Offerings, in aggregate the Company issued to various investors (i) 9,320,176 shares of commonstock for a purchase price of $4.56 per share, (ii) 23,026 shares of the Series B Preferred Stock for a purchase price of $760.00 per share, and (iii) warrants topurchase 7,894,704 shares of the Company’s common stock at an exercise price of $5.28 per share, for aggregate gross proceeds of approximately$60.0 million. After issuance costs of approximately $4.0 million, the net proceeds from the June 2012 Public Offerings were approximately $56.0 million.Through December 31, 2016, the Company issued 4,104.966 shares of common stock related to exercises of warrants in accordance with the June 2012Public Offerings.In conjunction with the Amgen Agreement Amendment (see Note 7), in June 2013, Amgen purchased 1,404,100 shares of the Company’s commonstock at a price per share of $7.12 and an aggregate purchase price of $10.0 million, which was received in June 2013. Under the terms of this agreement,Amgen agreed to certain 118Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) trading and other restrictions with respect to the Company’s common stock. The Company determined the fair value of the stock issued to Amgen to be$7.5 million. The excess of cash received over fair value of $2.5 million was deferred and is being allocated between the license and services based on theirrelative selling prices using best estimate of selling price.In February 2014, the Company closed an underwritten public offering for the issuance and sale of 5,031,250 shares of its common stock. The grosspublic offering proceeds were approximately $40.3 million. The net proceeds from the sale of the shares were approximately $37.5 million, after deductingthe underwriting discount and offering expenses.In December 2014, the Company also entered into a common stock purchase agreement which provided for the sale of 2,040,816 shares of its commonstock to Astellas at a price per share of $4.90 and an aggregate purchase price of $10.0 million, which was received in December 2014.On September 4, 2015, the Company entered into an Committed Equity Offering (an “CE Offering”) that is an at-the-market issuance sales agreement(the “Cantor Fitzgerald Agreement”) with Cantor Fitzgerald & Co. (“Cantor Fitzgerald”), pursuant to which the Company may issue and sell shares ofcommon stock having an aggregate offering price of up to $40.0 million, from time to time through Cantor Fitzgerald as its sales agent. The issuance and saleof these shares by the Company under the Cantor Fitzgerald Agreement, if any, are subject to the continued effectiveness of its registration statement on FormS-3, which was declared effective by the SEC on September 17, 2015.Sales of the Company’s common stock, through Cantor Fitzgerald, will be made on The NASDAQ Global Market by means of ordinary brokers’transactions at market prices or as otherwise agreed to by the Company and Cantor Fitzgerald. Subject to the terms and conditions of the Cantor FitzgeraldAgreement, Cantor Fitzgerald will use commercially reasonable efforts to sell the Company’s common stock from time to time, based upon our instructions(including any price, time or size limits or other customary parameters or conditions we may impose). The Company is not obligated to make any sales ofcommon stock under the Cantor Fitzgerald Agreement. The offering of shares of common stock pursuant to the Cantor Fitzgerald Agreement will terminateupon the earlier of (1) the sale of all common stock subject to the Cantor Fitzgerald Agreement or (2) termination of the Cantor Fitzgerald Agreement. TheCantor Fitzgerald Agreement may be terminated by Cantor Fitzgerald at any time upon ten days’ notice to the Company or may be terminated by theCompany at any time upon five day’ s notice to Cantor Fitzgerald, or by Cantor Fitzgerald at any time in certain circumstances, including the occurrence of amaterial adverse change in the Company’s business. The Company will pay Cantor Fitzgerald a commission rate equal to 3.0% of the gross proceeds of thesales price per share of any common stock sold through Cantor Fitzgerald under the Cantor Fitzgerald Agreement. The Company has also provided CantorFitzgerald with customary indemnification and contribution rights. As of December 31, 2016, 808,193 shares have been issued through Cantor Fitzgeraldunder the Cantor Fitzgerald Agreement for total net proceeds of approximately $8.9 million. Through February 23, 2017, the Company issued and sold993,408 shares for total net proceeds of approximately $11.0 million and $28.7 million remains available to us under the September 2015 RegistrationStatement.WarrantsAs of December 31, 2016, the Company had warrants outstanding to purchase 4.2 million shares of the Company’s common stock.In June 2012, warrants were issued pursuant to the June 2012 underwriting agreements the Company entered into in connection with two separate,concurrent offerings for our securities (the “June 2012 Public 119Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Offerings”). In accordance with the accounting guidance for valuing stock and warrants when stock is issued in conjunction with other securities, and thestock and other securities are to be accounted for as equity, the Company allocated the gross purchase proceeds using the relative fair value method. Foraccounting purposes, the June 2012 Public Offerings were considered to be one transaction. The fair value of the common stock issued in the June 2012Public Offerings was calculated based on the closing price of the stock on the commitment date as quoted on The NASDAQ Global Market.In October 2015, warrants to purchase 65,189 shares of the Company’s common stock at an exercise price of $6.90 per share were issued in accordancewith the Loan Agreement. Refer to Note 9 “Long-Term Debt”, for further details regarding the Loan Agreement.In February 2016, warrants to purchase 68,285 shares of the Company’s common stock at an exercise price of $6.59 per share were issued in accordancewith the Loan Agreement. The Company valued the warrants as of the date of issuance at $288,000 using the Black-Scholes option pricing model and thefollowing assumptions: a contractual term of five years, a risk-free interest rate of 1.7%, volatility of 75%, and the fair value of the Company’s common stockof $7.00.In August 2016, warrants to purchase 104,533 shares of the Company’s common stock at an exercise price of $5.28 per share were cash exercised inaccordance with the June 2012 public offerings underwriting agreements.In September 2016, the Company issued 690,580 shares of common stock related to cashless exercises of warrants in accordance with the June 2012public offerings.In December 2016, the Company issued 28,569 shares of common stock related to cashless exercises of warrants in accordance with the June 2012public offerings.Outstanding warrants as of December 31, 2016 were as follows: Numberof Shares ExercisePrice ExpirationDate Issued 6/25/2012 4,104,966 $5.28 06/25/17 Issued 10/19/2015 65,189 $6.90 10/19/20 Issued 02/10/2016 68,285 $6.59 02/10/21 Equity Incentive PlanTotal employee stock-based compensation expenses were $7.1 million, $4.6 million and $3.3 million for the years ended December 31, 2016, 2015and 2014, respectively.Stock Option Plans2004 PlanIn January 2004, the Board of Directors adopted the 2004 Equity Incentive Plan (the “2004 Plan”), which was approved by the stockholders inFebruary 2004. The 2004 Plan provides for the granting of incentive stock options, nonstatutory stock options, restricted stock, stock appreciation rights,stock performance units and stock performance shares to employees, directors and consultants. Under the 2004 Plan, options may be granted at prices notlower than 100% of the fair market value of the common stock on the date of grant for nonstatutory stock options and incentive stock options and may begranted for terms of up to ten years from the date of grant. 120Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Options granted to new employees generally vest 25% after one year and monthly thereafter over a period of four years. Options granted to existingemployees generally vest monthly over a period of four years. At the May 2013 Annual Meeting of Stockholders, the number of shares of common stockauthorized for issuance under the 2004 Plan was increased by 2,000,000. At the May 2015 Annual Meeting of Stockholders, the number of shares of commonstock authorized for issuance under the 2004 Plan was increased by 3,130,000. As of December 31, 2016, there were 1,588,300 shares of common stockreserved for issuance under the 2004 Plan.Stock OptionsActivity under the Equity Incentive Plan was as follows: SharesAvailable forGrant of Optionor Award Stock OptionsOutstanding WeightedAverage ExercisePrice per Share -Stock Options WeightedAverage RemainingContractual Life AggregateIntrinsicValue(in thousands) Balance at December 31, 2013 2,161,829 2,449,365 $15.15 Options granted (944,831) 944,831 8.80 Restricted stock units granted (43,500) — — Options exercised — (390) 6.00 Options forfeited/expired 95,980 (95,980) 39.74 Restricted stock units forfeited 1,000 — — Balance at December 31, 2014 1,270,478 3,297,826 $12.62 Increase in authorized shares 3,130,000 — — Options granted (1,175,730) 1,175,730 7.62 Restricted stock units granted (739,000) — — Options exercised — (68,635) 6.22 Options forfeited/expired 326,762 (326,762) 16.83 Restricted stock units forfeited 3,500 — — Balance at December 31, 2015 2,816,010 4,078,159 $10.94 Options granted (1,446,675) 1,446,675 7.10 Restricted stock units granted (47,000) — — Options exercised — (74,556) 6.75 Options forfeited/expired 257,465 (257,465) 24.25 Restricted stock units forfeited 8,500 — — Balance at December 31, 2016 1,588,300 5,192,813 $9.27 6.83 $21,294 Exercisable at December 31, 2016 3,364,286 $10.24 5.83 $12,771 Vested and expected to vest as ofDecember 31, 2016 5,147,387 $9.29 6.81 $21,075 Total intrinsic value of stock options exercised was $202,000, $94,000, and $1,000 during the years ended December 31, 2016, 2015 and 2014,respectively. The intrinsic value is calculated as the difference between the market value at the date of exercise and the exercise price of the shares. Themarket value as of December 31, 2016 was $12.15 per share as reported by NASDAQ. The weighted average grant date fair value of stock options granted was$4.77, $5.35 and $6.01 per share during the years ended December 31, 2016, 2015 and 2014, respectively.The number of option shares vested was 970,241, 713,078 and 601,647 in 2016, 2015 and 2014, respectively. The grant date fair value of optionshares vested was $4.9 million, $3.6 million and $3.0 million in 2016, 2015 and 2014, respectively. 121Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Restricted Stock UnitsRestricted stock unit activity was as follows: Number ofShares WeightedAverage AwardDate Fair Valueper Share Restricted stock units outstanding at December 31, 2013 41,663 $6.00 Restricted stock units granted 43,500 9.65 Restricted stock units vested (20,833) 6.00 Restricted stock units forfeited (1,000) 6.00 Unvested restricted stock units outstanding at December 31, 2014 63,330 8.51 Restricted stock units granted 54,000 7.96 Restricted stock units vested (42,078) 7.82 Restricted stock units forfeited (3,500) 8.68 Unvested restricted stock units outstanding at December 31, 2015 71,752 8.49 Restricted stock units granted 47,000 6.67 Restricted stock units vested (45,750) 8.69 Restricted stock units forfeited (8,500) 7.20 Unvested restricted stock units outstanding at December 31, 2016 64,502 7.19 Restricted stock activities were limited to non-executive employees for years ended December 31, 2016 and 2015.For the years ended December 31, 2016, 2015 and 2014, the total fair value of restricted stock units vested was $0.4 million, $0.3 million and$0.1 million, respectively. The Company measures compensation expense for restricted stock units at fair value on the grant date and recognizes the expenseover the expected vesting period. The fair value for restricted stock units is based on the closing price of the Company’s common stock on the grant date.Unvested restricted stock units are subject to repurchase at no cost to the Company.Restricted Stock Units that Contain Performance ConditionsPerformance stock unit activity was as follows: Number ofShares WeightedAverage AwardDate Fair Valueper Share Performance stock units outstanding at December 31, 2014 — $— Restricted stock units granted 685,000 7.00 Restricted stock units vested — — Restricted stock units forfeited — — Unvested restricted stock units outstanding at December 31, 2015 685,000 7.00 Restricted stock units granted — — Restricted stock units vested — — Restricted stock units forfeited — — Unvested restricted stock units outstanding at December 31, 2016 685,000 $7.00 122Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) During the year ended December 31, 2015, the Company granted 685,000 performance stock unit awards with a grant date fair value of $7.00 per sharethat contain performance conditions. As of December 31, 2016, all these performance stock units remain unvested.No performance stock units vested during the years ended December 31, 2016, 2015 and 2014 respectively. The Company measures compensationexpense for performance stock units at fair value on the grant date and recognizes the expense over the expected vesting period once it is probable that theperformance conditions will be achieved. The fair value for performance stock units is based on the closing price of the Company’s common stock on thegrant date. Unvested performance stock awards are subject to repurchase at no cost to the Company.Stock-Based CompensationThe Company applies the accounting guidance for stock compensation, which establishes accounting for share-based payment awards made toemployees, non-employees and directors, including employee stock options and employee stock purchases. Under this guidance, stock-based compensationcost is measured at the grant date based on the calculated fair value of the award, and is recognized as an expense on a straight-line basis over the employee’srequisite service period, generally the vesting period of the award.The following table summarizes stock-based compensation related to stock options, restricted stock awards, restricted stock unit, and employee stockpurchases (in thousands): Years Ended December 31, 2016 2015 2014 Research and development $4,252 $1,828 $1,361 General and administrative 2,894 2,739 1,969 Stock-based compensation included in operating expenses $7,146 $4,567 $3,330 Valuation AssumptionsEmployee Stock-Based CompensationThe Company uses the Black-Scholes option pricing model to determine the fair value of stock option grants to employees and directors and employeestock purchase plan shares. The key input assumptions used to estimate fair value of these awards include the exercise price of the award, the expected optionterm, the expected volatility of the Company’s stock over the option’s expected term, the risk-free interest rate over the option’s expected term, and theCompany’s expected dividend yield, if any.The fair value of share-based payments was estimated on the date of grant using the Black-Scholes option pricing model based on the followingweighted average assumptions: Year EndedDecember 31, 2016 Year EndedDecember 31, 2015 Year EndedDecember 31, 2014 EmployeeStock Options ESPP EmployeeStock Options ESPP EmployeeStock Options ESPP Risk-free interest rate 1.9% 0.5% 1.7% 0.3% 1.9% 0.2% Volatility 74.0% 74.0% 79.4% 75.3% 77.1% 86.0% Expected term in years 6.44 0.50 6.38 0.56 6.30 1.25 Expected dividend yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 123Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) The risk-free interest rate that the Company uses in the option pricing model is based on the U.S. Treasury zero-coupon issues with remaining termssimilar to the expected terms of the options. The Company does not anticipate paying dividends in the foreseeable future and therefore uses an expecteddividend yield of zero in the option pricing model. The Company is required to estimate forfeitures at the time of grant and revise those estimates insubsequent periods if actual forfeitures differ from those estimates. Historical data is used to estimate pre-vesting option forfeitures and record stock-basedcompensation expense only on those awards that are expected to vest.The Company uses its own historical exercise activity and extrapolates the life cycle of options outstanding to arrive at its estimated expected term fornew option grants. The Company uses its own volatility history based on its stock’s trading history for the expected term. The Company measurescompensation expense for awards of restricted stock and restricted stock units at fair value on the date of grant and recognizes the expense over the expectedvesting period. The fair value for restricted stock and restricted stock unit awards is based on the closing price of the Company’s common stock on the date ofgrant.As of December 31, 2016, there was $8.5 million of unrecognized compensation cost related to unvested stock options, which is expected to berecognized over a weighted-average period of 2.4 years, and there was $3.1 million of unrecognized compensation cost related to unvested restricted stockand performance stock units, which is expected to be recognized over a weighted-average period of 1.2 years. The fair value for restricted stock units is basedon the closing price of the Company’s common stock on the grant date.Non-employee Stock-Based CompensationThe Company records stock option grants to non-employees, excluding directors, at their fair value on the measurement date. The measurement ofstock-based compensation is subject to adjustment as the underlying equity instruments vest.There were no stock option grants to non-employees in the years ended December 31, 2016, 2015 or 2014. When terminating, if employees continue toprovide service to the Company as consultants and their grants are permitted to continue to vest, the expense associated with the continued vesting of therelated stock options is classified as non-employee stock compensation expense after the status change.In connection with services rendered by non-employees, the Company recorded stock-based compensation expense of $147,000, $27,000, and$50,000 in 2016, 2015 and 2014, respectively.ESPPIn January 2004, the Board of Directors adopted the 2004 ESPP, which was approved by the stockholders in February 2004. Under the 2004 ESPP,statutory employees may purchase common stock of the Company up to a specified maximum amount through payroll deductions. The stock is purchasedsemi-annually at a price equal to 85% of the fair market value at certain plan-defined dates. The 2004 ESPP was terminated in October 2015.In May 2015, the Board of Directors adopted the 2015 ESPP, which was approved by the stockholders in May 2015. The first purchase period underthe 2015 ESPP commenced on November 2, 2015. Under the 2015 ESPP, statutory employees may purchase common stock of the Company up to a specifiedmaximum amount through payroll deductions. The stock is purchased semi-annually at a price equal to 85% of the fair market value at certain plan-defineddates. 124Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) The Company issued 129,604, 21,167and 19,726 shares of common stock during 2016, 2015 and 2014, respectively, pursuant to the 2004 ESPP at anaverage price of $7.08, $3.24 and $3.38 per share, in 2016, 2015 and 2014, respectively.At December 31, 2016 the Company had 519,339 shares of common stock reserved for issuance under the 2015 ESPP.Note 12 — Income TaxesThe Company accounts for income taxes under the asset and liability method. Under this method, deferred tax assets and liabilities are determinedbased on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which thedifferences are expected to affect taxable income. Valuation allowances are established when necessary to reduce the deferred tax assets to the amountsexpected to be realized. The Company did not record an income tax provision in the years ended December 31, 2016, 2015, or 2014 because the Companyeither had net taxable losses in these periods or was able to utilize tax attributes to offset taxable income.For financial statement purposes, income (loss) before taxes includes the following components (in thousands): Years EndedDecember 31, 2016 2015 2014 United States $16,453 $(37,501) $(14,646) Foreign — — — Total $16,453 $(37,501) $(14,646) The Company recorded the following income tax provision as follows (in thousands): Years EndedDecember 31, 2016 2015 2014 Current: Federal $— $— $— State — — — Total $— $— $— Deferred: Federal $— $— $— State — — — Total $— $— $— 125Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Deferred income taxes reflect the net tax effect of temporary differences between the carrying amounts of assets and liabilities for financial reportingpurposes and the amounts used for income tax purposes. The significant components of the Company’s deferred tax assets and liabilities were as follows (inthousands): As of December 31, 2016 2015 2014 Deferred tax assets: Depreciation and amortization $766 $769 $780 Capitalized R&D 11,675 13,150 15,176 Reserves and accruals 10,258 12,899 6,217 Net operating losses 146,961 153,251 148,184 Tax credits 46,998 38,742 34,543 Total deferred tax assets 216,658 218,811 204,900 Less: Valuation allowance (216,658) (218,811) (204,900) Net deferred tax assets $— $— $— Realization of deferred tax assets is dependent upon future earnings, if any, the timing and amount of which are uncertain. Based upon the weight ofavailable evidence, which includes the Company’s historical operating performance, reported cumulative net losses since inception, expected future losses,and difficulty in accurately forecasting the Company’s future results, the Company maintained a full valuation allowance on the net deferred tax assets as ofDecember 31, 2016, 2015 and 2014. The valuation allowance was determined pursuant to the accounting guidance for income taxes, which requires anassessment of both positive and negative evidence when determining whether it is more likely than not that deferred tax assets are recoverable. The Companyintends to maintain a full valuation allowance on the U.S. deferred tax assets until sufficient positive evidence exists to support reversal of the valuationallowance. The valuation allowance decreased by $2.2 million in 2016 and increased by $13.9 million in 2015 and $1.0 million in 2014.As a result of certain realization requirements of accounting guidance for stock compensation, the table of deferred tax assets and liabilities shownabove does not include certain deferred tax assets at December 31, 2016, 2015 and 2014 that arose directly from tax deductions related to equitycompensation in excess of compensation recognized for financial reporting. Approximately $2.0 million of Federal and California net operating losses arerelated to tax stock option deductions in excess of book deductions. This amount will be credited to stockholders’ equity when it is realized.The following are the Company’s valuation and qualifying accounts (in thousands): Balance atBeginning ofPeriod Charged toExpenses Charged toOther Accounts Deductions Balance atEnd of Period Year Ended December 31, 2014: Deferred tax valuation allowance $203,863 $1,037 — — $204,900 Year Ended December 31, 2015: Deferred tax valuation allowance $204,900 $13,911 — — $218,811 Year Ended December 31, 2016: Deferred tax valuation allowance $218,811 $(2,153) — — $216,658 126Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) The following is a reconciliation of the statutory federal income tax rate to the Company’s effective tax rate: Years EndedDecember 31, 2016 2015 2014 Tax at federal statutory tax rate 34% (34)% (34)% State income tax, net of federal tax benefit 2% 0% (1)% State Apportionment (7)% 0% 28% Tax credits (net) (32)% (7)% (7)% Deferred tax assets (utilized) not benefited (15)% 37% 7% Stock-based compensation 7% 2% 5% NOL Expiration 9% 2% 2% Other 2% 0% 0% Total 0% 0% 0% The Company had federal net operating loss carryforwards of approximately $388.1 million and apportioned state net operating loss carryforwards ofapproximately $249.9 million before federal benefit at December 31, 2016. If not utilized, the federal and state operating loss carryforwards will begin toexpire in various amounts beginning 2020 and 2017, respectively. The net operating loss carryforwards include deductions for stock options.The Company had general business credit of approximately $44.4 million and $13.6 million for federal and state income tax purposes, respectively, atDecember 31, 2016. Amounts are comprised of Research and Development Credits and Orphan Drug Credits. If not utilized, the federal carryforwards willexpire in various amounts beginning in 2021. The California state credit can be carried forward indefinitely. Since its filing of its 2011 tax return, theCompany has claimed the orphan drug credit. For qualifying expenses, the orphan drug credit offers an increased benefit relative to the research anddevelopment credit taken in years prior.As required by California state law, the Company apportions income to California based on a “market-based” sourcing approach. Accordingly, theCompany’s California apportionment formula is sensitive to changes in the source of the Company’s mix of revenue.In general, under Section 382 of the Internal Revenue Code (“Section 382”), a corporation that undergoes an ‘ownership change’ is subject tolimitations on its ability to utilize its pre-change net operating losses and tax credits to offset future taxable income. The Company has performed a section382 analysis for the year ended December 31, 2016 and has not experienced an ownership change since 2006. A portion of the Company’s existing netoperating losses and tax credits are subject to limitations arising from previous ownership changes. Future changes in the Company’s stock ownership, someof which are outside of our control, could result in an ownership change under Section 382 and result in additional limitations.Section 59(e) of the Internal Revenue Code allows a Company to capitalize R&D expenses. The Company did not elect to capitalize R&D expenses inits 2014 tax return as they did not anticipate an ownership change under Section 382. For 2016 and 2015, the Company anticipates foregoing the election inits 2016 and 2015 tax return, respectively, as they do not anticipate an ownership change under Section 382.The Company follows the accounting guidance that prescribes a comprehensive model for how companies should recognize, measure, present, anddisclose in their financial statements uncertain tax positions taken or expected to be taken on a tax return. Tax positions are initially recognized in thefinancial statements when it is 127Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) more likely than not that the position will be sustained upon examination by the tax authorities. Such tax positions are initially and subsequently measuredas the largest amount of tax benefit that is greater than 50% likely of being realized upon ultimate settlement with the tax authority assuming full knowledgeof the position and relevant facts.The significant jurisdictions in which the Company files income tax returns are the United States and California. For jurisdictions in which tax filingsare made, the Company is subject to income tax examination for all fiscal years since inception. The IRS’s Large Business and International Divisionconcluded its audit of the 2009 tax year with no material adjustments. However, in general, the statute of limitations for tax liabilities for all years remainsopen for the purpose of adjusting the amounts of the losses and credits carried forward from those years.The following table summarizes the activity related to our gross unrecognized tax benefits (in thousands): Years EndedDecember 31, 2016 2015 Balance at the beginning of the year $6,715 $6,274 Decrease related to prior year tax positions 5 — Increase related to current year tax positions 845 441 Balance at the end of the year $7,565 $6,715 Included in the balance of unrecognized tax benefits as of December 31, 2016, 2015 and 2014 are $6.3 million, $5.5 million and $5.1 million of taxbenefits, respectively, that, if recognized, would result in adjustments to other tax accounts, primarily deferred taxes.The Company recognizes interest accrued related to unrecognized tax benefits and penalties as income tax expense. Related to the unrecognized taxbenefits noted above, the Company did not accrue any penalties or interest during 2016, 2015 or 2014. The Company does not expect its unrecognized taxbenefit to change materially over the next twelve months.Note 13 — Interest and Other Income, NetInterest and other income, net for the years ended December 31, 2016, 2015 and 2014, primarily consisted of interest income generated from theCompany’s cash, cash equivalents and investments. In 2015, interest income also included net gains realized upon disposal of equipment. 128Table of ContentsCYTOKINETICS, INCORPORATEDNOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued) Note 14 — Quarterly Financial Data (Unaudited)Quarterly results were as follows (in thousands, except per share data): FirstQuarter SecondQuarter ThirdQuarter FourthQuarter 2016 Total revenues $8,421 $5,802 $59,047 $33,138 Net income (loss) (12,455) (11,611) 33,362 7,157 Net income (loss) per share — basic $(0.31) $(0.29) $0.84 $0.18 Net income (loss) per share —diluted $(0.31) $(0.29) $0.77 $0.16 2015 Total revenues $4,414 $6,542 $7,945 $9,757 Net loss (8,872) (10,551) (8,849) (9,229) Net (loss) per share — basic and diluted $(0.23) $(0.27) $(0.23) $(0.24) Note 15 — Subsequent EventsOn February 1, 2017, the Company entered into a Royalty Purchase Agreement (the “Royalty Agreement”) with RPI Finance Trust (“RPI”), an entityrelated to Royalty Pharma. Under the Royalty Agreement, the Company sold a 4.5 percent royalty on potential worldwide sales of omecamtiv mecarbil (andpotentially other compounds with the same mechanism of action) that are subject to the Amgen Agreement (as amended) to RPI for a payment of$90.0 million. The royalty rate purchased may increase up to an additional 1 percent under certain circumstances. In addition, RPI has agreed to purchase$10.0 million of Cytokinetics’ common stock pursuant to a concurrently executed Common Stock Purchase Agreement with RPI.In February 2017, the Company provided notice to Amgen of its further exercise of its co-invest option in the additional amount of $30.0 million (i.e.to co-invest $40.0 million) in the Phase 3 development program of omecamtiv mecarbil under the Amgen Agreement. As a result, the Company is eligible toreceive an incremental royalty of up to 4% on increasing worldwide sales of omecamtiv mecarbil outside of Japan. Exercising its option and fully co-funding$40.0 million will afford the Company the right to co-promote omecamtiv mecarbil in institutional care settings in North America, with reimbursement byAmgen for certain sales force activities.From January 1, 2017 to February 23, 2017, the Company sold 185,215 shares pursuant to its CE offering with a weighted average sale price of $11.24for net proceeds of $2.1 million. 129Table of ContentsItem 9. Changes in and Disagreements With Accountants on Accounting and Financial DisclosureNone.Item 9A. Controls and ProceduresEvaluation of Disclosure Controls and Procedures. Our management evaluated, with the participation and under the supervision of our ChiefExecutive Officer and our Chief Financial Officer, the effectiveness of our disclosure controls and procedures (as defined in Rule 13a-15(e) under theExchange Act) as of the end of the period covered by this Annual Report on Form 10-K. Based on this evaluation, our Chief Executive Officer and our ChiefFinancial Officer have concluded that the Company’s disclosure controls and procedures were effective as of December 31, 2016.Management’s Report on Internal Control over Financial Reporting. Our management is responsible for establishing and maintaining adequateinternal control over financial reporting (as defined in Rule 13a-15(f) under the Exchange Act). Our management assessed the effectiveness of our internalcontrol over financial reporting as of December 31, 2016. In making this assessment, our management used the criteria set forth by the Committee ofSponsoring Organizations of the Treadway Commission in Internal Control-Integrated Framework 2013. Our management has concluded that, as ofDecember 31, 2016, our internal control over financial reporting is effective based on these criteria.Our independent registered public accounting firm, PricewaterhouseCoopers LLP, has audited the effectiveness of our internal control over financialreporting as of December 31, 2016, as stated in their report, which is included herein.Remediation of Previously Reported Material Weakness. A material weakness is a deficiency, or combination of deficiencies, in internal control overfinancial reporting, such that there is a reasonable possibility that a material misstatement of the annual or interim financial statements will not be preventedor detected on a timely basis. Management previously identified the following material weakness as of September 30, 2016:We did not maintain effective internal controls over the accounting for the completeness, accuracy and presentation and disclosure of clinical researchand development expenses and related clinical accrual accounts due to a design deficiency in the review of clinical trial expenses incurred under our clinicalresearch organization trial agreements, including in part, our review of information received from third party service providers that is used in the operation ofthis control. This material weakness resulted in the restatement of our clinical research and development expenses, related clinical accrual accounts andrelated financial disclosures as of and for the three and nine month periods ended September 30, 2016.In response to the material weakness described above, the Company developed a comprehensive remediation plan to address the material weakness.The remediation included the enhancement of review procedures around monthly fluctuation analysis over clinical research and development expenses andrelated clinical accruals, as well as the implementation of internal controls over the review of information received from third party service providers that areused in the operation of the control.During the quarter ended December 31, 2016, management tested the design and operating effectiveness of this new control and found it to be effectiveand concluded that the material weakness described above was remediated as of December 31, 2016.Changes in Internal Control over Financial Reporting. The changes described in “Remediation of Previously Reported Material Weaknesses”above, were changes in our internal control over financial reporting that occurred during the quarter ended December 31, 2016 that have materially affected,or are reasonably likely to materially affect, our internal control over financial reporting. 130Table of ContentsInherent Limitations on Effectiveness of Controls. Our management, including our Chief Executive Officer and Chief Financial Officer, does notexpect that our disclosure controls and procedures or our internal controls, will prevent all error and all fraud. A control system, no matter how well conceivedand operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control systemmust reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Because of the inherentlimitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, withinCytokinetics have been detected.Item 9B. Other InformationNone. 131Table of ContentsPART IIIItem 10. Directors, Executive Officers and Corporate GovernanceThe information regarding our directors and executive officers, our director nominating process and our audit committee is incorporated by referencefrom our definitive Proxy Statement for our 2016 Annual Meeting of Stockholders, where it appears under the headings “Board of Directors” and “ExecutiveOfficers.”Section 16(a) Beneficial Ownership Reporting ComplianceThe information regarding our Section 16 beneficial ownership reporting compliance is incorporated by reference from our definitive Proxy Statementdescribed above, where it appears under the headings “Section 16(a) Beneficial Ownership Reporting Compliance.”Code of EthicsWe have adopted a Code of Ethics that applies to all directors, officers and employees of the Company. We publicize the Code of Ethics throughposting the policy on our website, www.cytokinetics.com. We will disclose on our website any waivers of, or amendments to, our Code of Ethics within fourbusiness days following the date of such amendment or waiver.Item 11. Executive CompensationThe information required by this Item is incorporated by reference from our definitive Proxy Statement referred to in Item 10 above, where it appearsunder the headings “Executive Compensation” and “Compensation Committee Interlocks and Insider Participation.” Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder MattersThe information required by this Item regarding security ownership of certain beneficial owners and management is incorporated by reference from ourdefinitive Proxy Statement referred to in Item 10 above, where it appears under the heading “Security Ownership of Certain Beneficial Owners andManagement.”The following table summarizes the securities authorized for issuance under our equity compensation plans as of December 31, 2016: Plan Category Number of Securitiesto be IssuedUpon Exercise ofOutstanding Options,Warrants and Rights Weighted AverageExercise Price ofOutstanding Options,Warrants and Rights Number of SecuritiesRemaining Availablefor Future IssuanceUnder EquityCompensation Plans Equity compensation plans approved by stockholders 3,364,286 $10.25 2,107,699(1) Equity compensation plans not approved by stockholders — — — Total 3,364,286 $10.25 2,107,699 (1)Includes 519,399 shares of common stock reserved for issuance under the Employee Stock Purchase Plan.Item 13. Certain Relationships and Related Transactions, and Director IndependenceThe information required by this Item is incorporated by reference from our definitive Proxy Statement referred to in Item 10 above where it appearsunder the headings “Certain Business Relationships and Related Party Transactions” and “Board of Directors.” 132Table of ContentsItem 14. Principal Accounting Fees and ServicesThe information required by this Item is incorporated by reference from our definitive Proxy Statement referred to in Item 10 above, where it appearsunder the heading “Principal Accountant Fees and Services.” 133Table of ContentsPART IVItem 15. Exhibits and Financial Statement Schedules(a) The following documents are filed as part of this Form 10-K: (1) Financial Statements (included in Part II of this report): • Report of Independent Registered Public Accounting Firm • Consolidated Balance Sheets • Consolidated Statements of Comprehensive Loss • Consolidated Statements of Stockholders’ Equity • Consolidated Statements of Cash Flows • Notes to Consolidated Financial Statements (2) Financial Statement Schedules:None — All financial statement schedules are omitted because the information is inapplicable or presented in the notes to the financialstatements. (3) Exhibits: Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith 3.1 Amended and Restated Certificate of Incorporation. S-3 333-174869 June 13, 2011 3.1 3.2 Certificate of Amendment of Amended and RestatedCertificate of Incorporation. 10-Q 000-50633 August 4, 2011 3.2 3.3 Certificate of Amendment of Amended and RestatedCertificate of Incorporation. 8-K 000-50633 June 25, 2013 5.1 3.4 Certificate of Amendment of Amended and RestatedCertificate of Incorporation 8-K 000-50633 May 20, 2016 3.1 3.5 Amended and Restated Bylaws. S-1 333-112261 April 29, 2004 3.2 4.1 Specimen Common Stock Certificate. 10-Q 000-50633 May 9, 2007 4.1 4.2 Form of Warrant 10-Q 000-50633 August 6, 2012 4.6 4.3 Form of Common Stock Warrant Issued Pursuant to thatcertain Loan and Security Agreement, dated as of October 19,2015, by and among the Company, Oxford Finance LLC andSilicon Valley Bank 10-K 000-50633 March 3, 2016 4.6 10.1+ Amended and Restated 2004 Equity Incentive Plan 10-Q 000-50633 August 5, 2015 10.2 134Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith 10.2+ 2004 Employee Stock Purchase Plan 10-Q 000-50633 August 7, 2013 10.3 10.3+ 2015 Employee Stock Purchase Plan 10-Q 000-50633 August 5, 2015 10.42 10.4 Build-to-Suit Lease, dated May 27, 1997, by and betweenBritannia Pointe Grand Limited Partnership and Metaxen, LLC S-1 333-112261 April 29, 2004 10.5 10.5 First Amendment to Lease, dated April 13, 1998, by and betweenBritannia Pointe Grand Limited Partnership and Metaxen, LLC S-1 333-112261 January 27, 2004 10.6 10.6 Sublease Agreement, dated May 1, 1998, by and between theCompany and Metaxen, LLC S-1 333-112261 January 27, 2004 10.7 10.7 Sublease Agreement, dated March 1, 1999, by and betweenMetaxen, LLC and Exelixis Pharmaceuticals, Inc. S-1 333-112261 January 27, 2004 10.8 10.8 Assignment and Assumption Agreement and Consent, datedJuly 11, 1999, by and among Exelixis Pharmaceuticals, Metaxen,LLC, Xenova Group PLC and Britannia Pointe Grande LimitedPartnership S-1 333-112261 January 27, 2004 10.9 10.9 Second Amendment to Lease, dated July 11, 1999, by andbetween Britannia Pointe Grand Limited Partnership and ExelixisPharmaceuticals, Inc. S-1 333-112261 January 27, 2004 10.10 10.10 First Amendment to Sublease Agreement, dated July 20, 1999, byand between the Company and Metaxen S-1 333-112261 January 27, 2004 10.11 10.11 Agreement and Consent, dated July 20, 1999, by and amongExelixis Pharmaceuticals, Inc., the Company and Britannia PointeGrand Limited Partnership S-1 333-112261 January 27, 2004 10.12 10.12 Amendment to Agreement and Consent, dated July 31, 2000, byand between the Company, Exelixis, Inc., and Britannia PointeGrande Limited Partnership S-1 333-112261 January 27, 2004 10.13 135Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith 10.13 Assignment and Assumption of Lease, dated September 28,2000, by and between the Company and Exelixis, Inc. S-1 333-112261 January 27, 2004 10.14 10.14 Sublease Agreement, dated September 28, 2000, by and betweenthe Company and Exelixis, Inc. S-1 333-112261 January 27, 2004 10.15 10.15* Collaboration and Option Agreement, dated as of December 29,2006, by and between the Company and Amgen Inc. 10-K 000-50633 March 12, 2007 10.63 10.16 Form of Indemnification Agreement between the Company andeach of its directors and executive officers 10-Q 000-50633 August 5, 2008 10.1 10.17*+ Scientific Advisory Board Consulting Agreement, dated April 1,2008, by and between the Company and James H. Sabry 8-K 000-50633 April 2, 2008 10.66 10.18+ Amended and Restated Executive Employment Agreement,dated May 21, 2007, by and between the Company and RobertBlum 10-Q 000-50633 August 5, 2008 10.69 10.19+ Form of Executive Employment Agreement between theCompany and its executive officers 10-Q 000-50633 August 5, 2008 10.68 10.20* Amendment No. 1, dated June 17, 2008, to the Collaborationand Option Agreement by and between the Company andAmgen Inc. 10-K 000-50633 March 12, 2009 10.62 10.21* Amendment No. 2, dated September 30, 2008, to theCollaboration and Option Agreement by and between theCompany and Amgen Inc. 10-K 000-50633 March 12, 2009 10.63 10.22* Amendment No. 3, dated October 31, 2008, to the Collaborationand Option Agreement by and between the Company andAmgen Inc. 10-K 000-50633 March 12, 2009 10.65 10.23* Amendment No. 4, dated February 20, 2009, to theCollaboration and Option Agreement by and between theCompany and Amgen Inc. 10-K 000-50633 March 12, 2009 10.67 136Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith 10.24+ Form of Amendment No. 1 to Amended and Restated ExecutiveEmployment Agreements 10-K 000-50633 March 12, 2009 10.68 10.25 Third Amendment to Lease, dated December 10, 2010, by andbetween the Company and Britannia Pointe Grand LimitedPartnership 10-K 000-50633 March 11, 2011 10.65 10.26* Amendment No. 5, dated November 1, 2010, to theCollaboration and Option Agreement by and between theCompany and Amgen Inc. 10-K 000-50633 March 11, 2011 10.66 10.27* Consulting Agreement between the Company and David J.Morgans, dated November 1, 2011 10-K 000-50633 March 13, 2012 10.42 10.28* Amendment No. 1, dated May 1, 2012, to ConsultingAgreement between the Company and David J. Morgans, datedNovember 1, 2011 10-Q 000-50633 May 4, 2012 10.43 10.29* Amendment No. 2, dated October 30, 2012 to ConsultingAgreement between the Company and David J. Morgans, datedNovember 1, 2011 10-K 000-50633 March 15, 2013 10.44 10.30+ 2015 Compensation Information for the Company’s NamedExecutive Officers 8-K 000-50633 March 2, 2015 10.1 10.31+ Form of Option Agreement 10-K 000-50633 March 15, 2013 10.46 10.32+ Form of Restricted Stock Unit Award Agreement 10-K 000-50633 March 15, 2013 10.47 10.33 Common Stock Purchase Agreement dated June 11, 2013, byand between the Company and Amgen Inc. 8-K 000-50633 June 12, 2013 10.48 10.34* Amendment No. 6, dated June 11, 2013, to the Collaborationand Option Agreement by and between the Company andAmgen Inc. 10-Q 000-50633 August 7, 2013 10.46 10.35+ Form of Executive Employment Agreement between theCompany and its executive officers 10-K 000-50633 March 7, 2014 10.39 10.36 Common Stock Purchase Agreement by and between theCompany and Astellas Pharma Inc. dated December 22, 2014 8-K 000-50633 December 23, 2014 10.46 137Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith10.37* Amended and Restated License and CollaborationAgreement, dated December 22, 2014, by and between theCompany and Astellas Pharma Inc. 10-K 000-50633 March 6, 2015 10.40 10.38* Amendment No. 7, dated March 19, 2015, to theCollaboration and Option Agreement by and between theCompany and Amgen Inc. 10-Q 000-50633 May 4, 2015 10.41 10.39 Controlled Equity Offering Sales Agreement, dated as ofSeptember 4, 2015, by and between the Company and CantorFitzgerald & Co. 8-K 000-50633 September 4, 2015 10.43 10.40* Loan and Security Agreement, dated as of October 19, 2015,by and among the Company, Oxford Finance LLC andSilicon Valley Bank 10-K 000-50633 March 3, 2016 10.40 10.41 Fourth Amendment to Build to Suit Lease, dated March 1,2016, by and between the Company and Britannia PointeGrand Limited Partnership 10-Q 000-50633 May 5, 2016 10.41 10.42* Amendment to the Amended and Restated License andCollaboration Agreement between the Company and AstellasPharma Inc., dated July 27, 2016 10-Q/A 000-50633 January 20, 2017 10.42 10.43* Letter of Agreement by and between the Company andAmgen Inc. and Les Laboratoires Servier and Institut deRecherches Internationales Servier, dated August 29, 2016 10-Q 000-50633 November 3, 2016 10.43 10.44** Royalty Purchase Agreement by and between the Companyand RPI Finance Trust, dated February 1, 2017 X10.45 Common Stock Purchase Agreement by and between theCompany and RPI Finance Trust, dated February 1, 2017 X23.1 Consent of Independent registered public accounting firm X 138Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form FileNo. FilingDate Exh.No. FiledHerewith24.1 Power of Attorney (included in the signature page to thisreport) X31.1 Certification of Principal Executive Officer pursuant toSection 302 of the Sarbanes-Oxley Act of 2002 X31.2 Certification of Principal Financial Officer pursuant toSection 302 of the Sarbanes-Oxley Act of 2002 X 32.1 Certifications of the Principal Executive Officer and thePrincipal Financial Officer pursuant to Section 906 of theSarbanes-Oxley Act of 2002 (18 U.S.C. Section 1350) (1) X101.INS XBRL Instance Document X101.SCH XBRL Taxonomy Extension Schema Document X101.CAL XBRL Taxonomy Extension Calculation LinkbaseDocument X101.DEF XBRL Taxonomy Extension Definition LinkbaseDocument X101.LAB XBRL Taxonomy Extension Label Linkbase Document X101.PRE XBRL Taxonomy Extension Presentation LinkbaseDocument X *Portions of this Exhibit are subject to a confidential treatment order. **Registrant has requested confidential treatment for portions of this Exhibit. +Management contract or compensatory plan. (1)This certification accompanies the Form 10-K to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to beincorporated by reference into any filing of the Registrant under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, asamended (whether made before or after the date of the Form 10-K), irrespective of any general incorporation language contained in such filing.(b) ExhibitsThe exhibits listed under Item 15(a)(3) hereof are filed as part of this Form 10-K, other than Exhibit 32.1 which shall be deemed furnished. 139Table of Contents(c) Financial Statement SchedulesNone — All financial statement schedules are omitted because the information is inapplicable or presented in the notes to the financial statements.Item 16. Form 10-K SummaryNone. 140Table of ContentsSIGNATURESPursuant to the requirements of Section 13 or 15(d) of the Securities and Exchange Act of 1934, the registrant has duly caused this report to be signedon its behalf by the undersigned, thereunto duly authorized. CYTOKINETICS, INCORPORATEDBy: /S/ ROBERT I. BLUM Robert I. BlumPresident, Chief Executive Officer and DirectorDated: March 6, 2017POWER OF ATTORNEYKNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Robert I. Blum and SharonA. Barbari, and each of them, his true and lawful attorneys-in-fact, each with full power of substitution, for him in any and all capacities, to sign anyamendments to this Annual Report on Form 10-K and to file the same, with exhibits thereto and other documents in connection therewith, with the Securitiesand Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact or their substitute or substitutes may do or cause to be doneby virtue hereof.Pursuant to the requirements of the Securities and Exchange Act of 1934, this report has been signed below by the following persons on behalf of theregistrant and in the capacities and on the dates indicated. Signature Title Date/s/ ROBERT I. BLUM Robert I. Blum President, Chief Executive Officer andDirector (Principal Executive Officer) March 6, 2017/s/ SHARON A. BARBARISharon A. Barbari Executive Vice President, Finance and Chief FinancialOfficer (Principal Financial and Accounting Executive) March 6, 2017/s/ L. PATRICK GAGE, PH.D.L. Patrick Gage, Ph.D. Chairman of the Board of Directors March 6, 2017/s/ SANTO J. COSTASanto J. Costa Director March 6, 2017/s/ JOHN T. HENDERSON, M.B. CH.B.John T. Henderson, M.B. Ch.B. Director March 6, 2017/s/ EDWARD KAYE, M.D.Edward Kaye, M.D. Director March 6, 2017/s/ B. LYNNE PARSHALL, ESQ.B. Lynne Parshall, Esq. Director March 6, 2017/s/ SANDFORD D. SMITHSandford D. Smith Director March 6, 2017/s/ WENDELL WIERENGA, PH.D.Wendell Wierenga, Ph.D. Director March 6, 2017 141Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith 3.1 Amended and Restated Certificate of Incorporation. S-3 333-174869 June 13, 2011 3.1 3.2 Certificate of Amendment of Amended and Restated Certificate ofIncorporation. 10-Q 000-50633 August 4, 2011 3.2 3.3 Certificate of Amendment of Amended and Restated Certificate ofIncorporation. 8-K 000-50633 June 25, 2013 5.1 3.4 Certificate of Amendment of Amended and Restated Certificate ofIncorporation 8-K 000-50633 May 20, 2016 3.1 3.5 Amended and Restated Bylaws. S-1 333-112261 April 29, 2004 3.2 4.1 Specimen Common Stock Certificate. 10-Q 000-50633 May 9, 2007 4.1 4.2 Form of Warrant to Purchase Common Stock, originally issuedJune 25, 2012 10-Q 000-50633 August 6, 2012 4.6 4.3 Form of Common Stock Warrant Issued Pursuant to that certainLoan and Security Agreement, dated as of October 19, 2015, byand among the Company, Oxford Finance LLC and SiliconValley Bank 10-K 000-50633 March 3, 2016 4.6 10.1+ Amended and Restated 2004 Equity Incentive Plan 10-Q 000-50633 August 5, 2015 10.2 10.2+ 2004 Employee Stock Purchase Plan 10-Q 000-50633 August 7, 2013 10.3 10.3+ 2015 Employee Stock Purchase Plan 10-Q 000-50633 August 5, 2015 10.42 10.4 Build-to-Suit Lease, dated May 27, 1997, by and betweenBritannia Pointe Grand Limited Partnership and Metaxen, LLC S-1 333-112261 April 29, 2004 10.5 10.5 First Amendment to Lease, dated April 13, 1998, by and betweenBritannia Pointe Grand Limited Partnership and Metaxen, LLC S-1 333-112261 January 27, 2004 10.6 10.6 Sublease Agreement, dated May 1, 1998, by and between theCompany and Metaxen, LLC S-1 333-112261 January 27, 2004 10.7 10.7 Sublease Agreement, dated March 1, 1999, by and betweenMetaxen, LLC and Exelixis Pharmaceuticals, Inc. S-1 333-112261 January 27, 2004 10.8 10.8 Assignment and Assumption Agreement and Consent, datedJuly 11, 1999, by and among Exelixis Pharmaceuticals, Metaxen,LLC, Xenova Group PLC and Britannia Pointe Grande LimitedPartnership S-1 333-112261 January 27, 2004 10.9 142Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith10.9 Second Amendment to Lease, dated July 11, 1999, by and betweenBritannia Pointe Grand Limited Partnership and ExelixisPharmaceuticals, Inc. S-1 333-112261 January 27, 2004 10.10 10.10 First Amendment to Sublease Agreement, dated July 20, 1999, by andbetween the Company and Metaxen S-1 333-112261 January 27, 2004 10.11 10.11 Agreement and Consent, dated July 20, 1999, by and among ExelixisPharmaceuticals, Inc., the Company and Britannia Pointe GrandLimited Partnership S-1 333-112261 January 27, 2004 10.12 10.12 Amendment to Agreement and Consent, dated July 31, 2000, by andbetween the Company, Exelixis, Inc., and Britannia Pointe GrandeLimited Partnership S-1 333-112261 January 27, 2004 10.13 10.13 Assignment and Assumption of Lease, dated September 28, 2000, byand between the Company and Exelixis, Inc. S-1 333-112261 January 27, 2004 10.14 10.14 Sublease Agreement, dated September 28, 2000, by and between theCompany and Exelixis, Inc. S-1 333-112261 January 27, 2004 10.15 10.15* Collaboration and Option Agreement, dated as of December 29, 2006,by and between the Company and Amgen Inc. 10-K 000-50633 March 12, 2007 10.63 10.16 Form of Indemnification Agreement between the Company and eachof its directors and executive officers 10-Q 000-50633 August 5, 2008 10.1 10.17*+ Scientific Advisory Board Consulting Agreement, dated April 1, 2008,by and between the Company and James H. Sabry 8-K 000-50633 April 2, 2008 10.66 10.18+ Amended and Restated Executive Employment Agreement, datedMay 21, 2007, by and between the Company and Robert Blum 10-Q 000-50633 August 5, 2008 10.69 10.19+ Form of Executive Employment Agreement between the Company andits executive officers 10-Q 000-50633 August 5, 2008 10.68 10.20* Amendment No. 1, dated June 17, 2008, to the Collaboration andOption Agreement by and between the Company and Amgen Inc. 10-K 000-50633 March 12, 2009 10.62 143Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith10.21* Amendment No. 2, dated September 30, 2008, to the Collaborationand Option Agreement by and between the Company and Amgen Inc. 10-K 000-50633 March 12, 2009 10.63 10.22* Amendment No. 3, dated October 31, 2008, to the Collaboration andOption Agreement by and between the Company and Amgen Inc. 10-K 000-50633 March 12, 2009 10.65 10.23* Amendment No. 4, dated February 20, 2009, to the Collaboration andOption Agreement by and between the Company and Amgen Inc. 10-K 000-50633 March 12, 2009 10.67 10.24+ Form of Amendment No. 1 to Amended and Restated ExecutiveEmployment Agreements 10-K 000-50633 March 12, 2009 10.68 10.25 Third Amendment to Lease, dated December 10, 2010, by and betweenthe Company and Britannia Pointe Grand Limited Partnership 10-K 000-50633 March 11, 2011 10.65 10.26* Amendment No. 5, dated November 1, 2010, to the Collaboration andOption Agreement by and between the Company and Amgen Inc. 10-K 000-50633 March 11, 2011 10.66 10.27* Consulting Agreement between the Company and David J. Morgans,dated November 1, 2011 10-K 000-50633 March 13, 2012 10.42 10.28* Amendment No. 1, dated May 1, 2012, to Consulting Agreementbetween the Company and David J. Morgans, dated November 1, 2011 10-Q 000-50633 May 4, 2012 10.43 10.29* Amendment No. 2, dated October 30, 2012 to Consulting Agreementbetween the Company and David J. Morgans, dated November 1, 2011 10-K 000-50633 March 15, 2013 10.44 10.30+ 2015 Compensation Information for the Company’s Named ExecutiveOfficers 8-K 000-50633 March 2, 2015 10.1 10.31+ Form of Option Agreement 10-K 000-50633 March 15, 2013 10.46 10.32+ Form of Restricted Stock Unit Award Agreement 10-K 000-50633 March 15, 2013 10.47 10.33 Common Stock Purchase Agreement dated June 11, 2013, by andbetween the Company and Amgen Inc. 8-K 000-50633 June 12, 2013 10.48 144Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form File No. Filing Date Exh.No. FiledHerewith10.34* Amendment No. 6, dated June 11, 2013, to the Collaboration andOption Agreement by and between the Company and Amgen Inc. 10-Q 000-50633 August 7, 2013 10.46 10.35+ Form of Executive Employment Agreement between the Companyand its executive officers 10-K 000-50633 March 7, 2014 10.39 10.36 Common Stock Purchase Agreement by and between the Companyand Astellas Pharma Inc. dated December 22, 2014 8-K 000-50633 December 23, 2014 10.46 10.37* Amended and Restated License and Collaboration Agreement,dated December 22, 2014, by and between the Company andAstellas Pharma Inc. 10-K 000-50633 March 6, 2015 10.40 10.38* Amendment No. 7, dated March 19, 2015, to the Collaboration andOption Agreement by and between the Company and Amgen Inc. 10-Q 000-50633 May 4, 2015 10.41 10.39 Controlled Equity Offering Sales Agreement, dated as ofSeptember 4, 2015, by and between the Company and CantorFitzgerald & Co. 8-K 000-50633 September 4, 2015 10.43 10.40* Loan and Security Agreement, dated as of October 19, 2015, by andamong the Company, Oxford Finance LLC and Silicon ValleyBank 10-K 000-50633 March 3, 2016 4.6 10.41 Fourth Amendment to Build to Suit Lease, dated March 1, 2016, byand between the Company and Britannia Pointe Grand LimitedPartnership 10-Q 000-50633 May 5, 2016 10.41 10.42* Amendment to the Amended and Restated License andCollaboration Agreement between the Company and AstellasPharma Inc., dated July 27, 2016 10-Q/A 000-50633 January 20, 2017 10.42 10.43* Letter of Agreement by and between the Company and Amgen Inc.and Les Laboratoires Servier and Institut de RecherchesInternationales Servier, dated August 29, 2016 10-Q 000-50633 November 3, 2016 10.43 10.44** Royalty Purchase Agreement by and between the Company andRPI Finance Trust, dated February 1, 2017 X 145Table of Contents Incorporated by Reference ExhibitNo. Exhibits Form FileNo. FilingDate Exh.No. FiledHerewith10.45 Common Stock Purchase Agreement by and between the Company and RPI Finance Trust,dated February 1, 2017 X23.1 Consent of Independent registered public accounting firm X24.1 Power of Attorney (included in the signature page to this report) X31.1 Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-OxleyAct of 2002 X31.2 Certification of Principal Financial Officer pursuant to Section 302 of the Sarbanes-OxleyAct of 2002 X32.1 Certifications of the Principal Executive Officer and the Principal Financial Officer pursuantto Section 906 of the Sarbanes-Oxley Act of 2002 (18 U.S.C. Section 1350) (1) X101.INS XBRL Instance Document X101.SCH XBRL Taxonomy Extension Schema Document X101.CAL XBRL Taxonomy Extension Calculation Linkbase Document X101.DEF XBRL Taxonomy Extension Definition Linkbase Document X101.LAB XBRL Taxonomy Extension Label Linkbase Document X101.PRE XBRL Taxonomy Extension Presentation Linkbase Document X *Portions of this Exhibit are subject to a confidential treatment order. **Registrant has requested confidential treatment for portions of this Exhibit. +Management contract or compensatory plan. (1)This certification accompanies the Form 10-K to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to beincorporated by reference into any filing of the Registrant under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, asamended (whether made before or after the date of the Form 10-K), irrespective of any general incorporation language contained in such filing.(b) ExhibitsThe exhibits listed under Item 15(a)(3) hereof are filed as part of this Form 10-K, other than Exhibit 32.1 which shall be deemed furnished.(c) Financial Statement SchedulesNone — All financial statement schedules are omitted because the information is inapplicable or presented in the notes to the financial statements. 146EXHIBIT 10.44CONFIDENTIALEXECUTION VERSION[ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities andExchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.ROYALTY PURCHASE AGREEMENTBY AND BETWEENCYTOKINETICS, INCORPORATEDANDRPI FINANCE TRUSTDATED AS OF FEBRUARY 1, 2017TABLE OF CONTENTS Page ARTICLE 1 PURCHASE, SALE AND ASSIGNMENT OF THE ROYALTY 1Section 1.1 Purchase, Sale and Assignment 1Section 1.2 Purchase Price 1Section 1.3 No Assumed Obligations, Etc. 1Section 1.4 True Sale 2Section 1.5 Stock Purchase Agreement 2ARTICLE 2 CLOSING 2Section 2.1 Closing 2Section 2.2 Payment of Purchase Price 2Section 2.3 Closing Certificates 3Section 2.4 Bill of Sale 3Section 2.5 [Reserved] 3Section 2.6 Lender Consent 3Section 2.7 Licensee Consent 3Section 2.8 Form W8-BEN 3ARTICLE 3 REPRESENTATIONS AND WARRANTIES 4Section 3.1 Seller’s Representations and Warranties 4Section 3.2 The Buyer’s Representations and Warranties 10Section 3.3 No Implied Representations and Warranties 11ARTICLE 4 CONDITIONS TO CLOSING 12Section 4.1 Conditions to the Buyer’s Obligations 12Section 4.2 Conditions to the Seller’s Obligations 13ARTICLE 5 COVENANTS 14Section 5.1 Disclosures 14Section 5.2 Payments Received In Error; Interest Payments 14Section 5.3 Royalty Reduction 15Section 5.4 Royalty Reports; Other Information; Notices 15Section 5.5 Inspections and Audits of Licensee 16Section 5.6 Amendment of License Agreement 16Section 5.7 Maintenance of License Agreement; Efforts to Commercialize 16Section 5.8 Enforcement of License Agreement 17Section 5.9 Termination of License Agreement; Seller Product Opportunity 17Section 5.10 Preservation of Rights 18Section 5.11 Enforcement; Infringement Claims 18Section 5.12 Efforts to Consummate Transactions 19Section 5.13 Sale of Royalty to Third Party 19Section 5.14 Further Assurances 19ARTICLE 6 INDEMNIFICATION 20Section 6.1 General Indemnity 20Section 6.2 Notice of Claims 20Section 6.3 Limitations on Liability 20Section 6.4 Third Party Claims 21Section 6.5 Exclusive Remedy 21ARTICLE 7 TERMINATION 22Section 7.1 Grounds for Termination 22Section 7.2 Automatic Termination 22Section 7.3 Survival 22 (i)ARTICLE 8 CONFIDENTIALITY 22Section 8.1 Confidentiality 22Section 8.2 Authorized Disclosure 23ARTICLE 9 MISCELLANEOUS 24Section 9.1 Definitions 24Section 9.2 Certain Interpretations 30Section 9.3 Headings 31Section 9.4 Notices 31Section 9.5 Expenses 32Section 9.6 Assignment 32Section 9.7 Amendment and Waiver 32Section 9.8 Entire Agreement 33Section 9.9 No Third Party Beneficiaries 33Section 9.10 Governing Law 33Section 9.11 JURISDICTION; VENUE 33Section 9.12 Severability 34Section 9.13 Specific Performance 34Section 9.14 Trustee Capacity of Wilmington Trust Company 34Section 9.15 Relationship of Parties 35Section 9.16 Counterparts 35Index of Exhibits Exhibit A: Stock Purchase AgreementExhibit B: Form of Bill of Sale (ii)CONFIDENTIALEXECUTION VERSION[ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the securities andexchange commission pursuant to rule 24b-2 of the securities exchange act of 1934, as amended.ROYALTY PURCHASE AGREEMENTThis ROYALTY PURCHASE AGREEMENT, dated as of February 1, 2017 (this “Agreement”), is made and entered into by and between Cytokinetics,Incorporated, a Delaware corporation (the “Seller”), on the one hand, and RPI Finance Trust, a Delaware statutory trust (the “Buyer”), on the other hand.W I T N E S S E T H:WHEREAS, pursuant to the License Agreement and following Licensee’s exercise of the Licensee Option, the Seller granted to Licensee an exclusive,royalty bearing license under the Intellectual Property to, among other things, sell the Compounds, including CK-452, and Licensee, in partial considerationfor such license, agreed to pay the Royalty to the Seller;WHEREAS, the Seller exercised its Co-Invest Option in respect of CK-452 in the amount of $10,000,000, and may in the future exercise its Co-InvestOption in respect of CK-452 for up to an additional $30,000,000; andWHEREAS, the Buyer desires to purchase the Purchased Royalty (a portion of the Royalty) from the Seller, and the Seller desires to sell the PurchasedRoyalty to the Buyer.NOW THEREFORE, in consideration of the representations, warranties, covenants and agreements set forth herein and for good and valuableconsideration, the receipt and adequacy of which are hereby acknowledged, the Seller and the Buyer hereby agree as follows:ARTICLE 1PURCHASE, SALE AND ASSIGNMENT OF THE ROYALTYSection 1.1 Purchase, Sale and Assignment. Upon the terms and subject to the conditions of this Agreement, at the Closing, the Seller shall sell,transfer, assign and convey to the Buyer, and the Buyer shall purchase, acquire and accept from the Seller, all of the Seller’s right, title and interest in and tothe Purchased Royalty.Section 1.2 Purchase Price. The purchase price to be paid to the Seller for the sale, transfer, assignment and conveyance of the Seller’s right, titleand interest in and to the Purchased Royalty to the Buyer is NINETY MILLION DOLLARS ($90,000,000) (the “Purchase Price”).Section 1.3 No Assumed Obligations, Etc. Notwithstanding any provision in this Agreement to the contrary, the Buyer is purchasing, acquiringand accepting only the Purchased Royalty and is not assuming any liability or obligation of the Seller of whatever nature, whether presently in existence orarising or asserted hereafter, under the License Agreement or otherwise. Except as specifically set forth herein in respect of the Purchased Royalty purchased,acquired and accepted hereunder, the Buyer does not, by such purchase, acquisition and acceptance, acquire any other contract rights of the Seller under theLicense Agreement or any other assets of the Seller.Section 1.4 True Sale. It is the intention of the parties hereto that the sale, transfer, assignment and conveyance contemplated by this Agreementconstitute a sale of the Purchased Royalty from the Seller to the Buyer and not a financing transaction, borrowing or loan. Accordingly, the Seller shall treatthe sale, transfer, assignment and conveyance of the Purchased Royalty as a sale of an “account” or a “payment intangible” (as appropriate) in accordancewith the UCC, and the Seller hereby authorizes the Buyer (at Buyer’s cost and expense) to file financing statements (and continuation statements with respectto such financing statements when applicable) naming the Seller as the debtor and the Buyer as the secured party in respect of the Purchased Royalty. Not inderogation of the foregoing statement of the intent of the parties hereto in this regard, and for the purpose of providing additional assurance to the Buyer inthe event that, despite the intent of the parties hereto, the sale, transfer, assignment and conveyance contemplated hereby is hereafter held not to be a sale, theSeller does hereby grant to the Buyer, as security for the obligations of the Seller hereunder, a first priority security interest in all right, title and interest of theSeller in, to and under the Purchased Royalty and any “proceeds” (as such term is defined in the UCC) thereof, and the Seller does hereby authorize theBuyer, from and after the Closing, to file such financing statements (and continuation statements with respect to such financing statements when applicable)as may be necessary to perfect such security interest. Following the termination of this Agreement, upon the Seller’s request, the Buyer shall, at the expense ofthe Seller, file a UCC-3 termination statement terminating the security interest granted in this Section.Section 1.5 Stock Purchase Agreement. Simultaneous with the execution and delivery of this Agreement, each of the Seller and the Buyer shalldeliver to the other party hereto a duly executed Stock Purchase Agreement, in the form attached hereto as Exhibit A (the “Stock Purchase Agreement”)ARTICLE 2CLOSINGSection 2.1 Closing. The Closing shall take place on the third Business Day after the date on which the conditions set forth in Article 4 havebeen satisfied, or at such other place, time and date as the parties hereto may mutually agree. Subject to the provisions of Article 7, failure to consummate thesale, transfer, assignment and conveyance of the Purchased Royalty as provided in this Article 2 on the date and at the place determined pursuant to thisSection 2.1 shall not result in a termination of this Agreement and shall not relieve either party hereto of any of its respective obligations hereunder.Section 2.2 Payment of Purchase Price. At the Closing, the Buyer shall deliver (or cause to be delivered) payment of the Purchase Price to theSeller by wire transfer of immediately available funds to one or more accounts specified by the Seller in writing. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.2Section 2.3 Closing Certificates.(a) Seller’s Closing Certificate.(i) At the Closing, the Seller shall deliver to the Buyer a certificate of the Secretary or an Assistant Secretary of the Seller, dated theClosing Date, certifying as to (i) the incumbency of the officer of the Seller executing this Agreement, (ii) the copies of Seller’s certificate ofincorporation, bylaws and resolutions adopted by the Seller’s board of directors authorizing the execution and delivery by the Seller of thisAgreement and the consummation by the Seller of the transactions contemplated hereby and (iii) the copies of all the documentation (except forSchedule 3.1(j), to the extent required by the Licensee Consent) Delivered by the Seller at the Closing.(ii) At the Closing, to the extent Schedule 3.1(j) cannot be included in the certificate delivered to the Buyer under Section 2.3(a)(i), theSeller shall deliver to counsel for the Buyer a certificate of the Secretary or an Assistant Secretary of the Seller, dated the Closing Date, certifyingas to Schedule 3.1(j).(b) Buyer’s Closing Certificate. At the Closing, the Buyer shall deliver to the Seller a certificate of an authorized person of the owner trustee ofthe Buyer, dated the Closing Date, certifying as to the incumbency of the officers executing this Agreement on behalf of the Buyer.Section 2.4 Bill of Sale. At the Closing, upon confirmation of the receipt of the Purchase Price, the Seller shall deliver to the Buyer a dulyexecuted bill of sale evidencing the sale, transfer, assignment and conveyance of the Purchased Royalty, substantially in the form attached hereto asExhibit B (the “Bill of Sale”).Section 2.5 [Reserved]Section 2.6 Lender Consent. At the Closing, the Seller shall deliver to the Buyer a duly executed agreement from Lender consenting to the saleof the Purchased Royalty pursuant to this Agreement and the grant of the Buyer’s security interest under Section 1.4 and terminating Lender’s securityinterest in the Purchased Royalty and the related account or payment intangible Delivered by the Seller (the “Lender Consent”).Section 2.7 Licensee Consent. At the Closing, the Seller shall deliver to the Buyer a duly executed agreement from Licensee in the formDelivered by the Seller (the “Licensee Consent”).Section 2.8 Form W8-BEN. At the Closing, the Buyer shall deliver to the Seller a valid, properly executed IRS Form W8-BEN certifying that theBuyer is exempt from U.S. federal withholding tax with respect to any and all payments of in respect of the Purchased Royalty. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.3ARTICLE 3REPRESENTATIONS AND WARRANTIESSection 3.1 Seller’s Representations and Warranties. The Seller represents and warrants to the Buyer that as of the date hereof:(a) Existence; Good Standing. The Seller is a corporation duly incorporated, validly existing and in good standing under the laws of the State ofDelaware. The Seller is duly licensed or qualified to do business and is in corporate good standing in each jurisdiction in which the nature of the businessconducted by it or the character or location of the properties and assets owned, leased or operated by it makes such licensing or qualification necessary,except where the failure to be so licensed or qualified and in corporate good standing has not and would not reasonably be expected to have, eitherindividually or in the aggregate, a Material Adverse Effect.(b) Authorization. The Seller has all requisite corporate power and authority to execute, deliver and perform its obligations under thisAgreement. The execution, delivery and performance of this Agreement, and the consummation of the transactions contemplated hereby, have been dulyauthorized by all necessary corporate action on the part of the Seller.(c) Enforceability. This Agreement has been duly executed and delivered by an authorized officer of the Seller and constitutes the valid andbinding obligation of the Seller, enforceable against the Seller in accordance with its terms, except as may be limited by applicable Bankruptcy Laws or bygeneral principles of equity (whether considered in a proceeding in equity or at law).(d) No Conflicts. The execution, delivery and performance by the Seller of this Agreement and the consummation of the transactionscontemplated hereby do not and shall not (i) contravene or conflict with the certificate of incorporation or bylaws of the Seller, (ii) contravene or conflictwith or constitute a material default under any law or Judgment binding upon or applicable to the Seller, (iii) contravene or conflict with or constitute adefault under the License Agreement or the Loan Agreement or (iv) except as would not reasonably be expected to result in a Material Adverse Effect,contravene or conflict with or constitute a material default under any other material contract or other material agreement binding upon or applicable to theSeller.(e) Consents. Except for the consents that have been obtained on or prior to the Closing or filings required by the federal securities laws or stockexchange rules, no consent, approval, license, order, authorization, registration, declaration or filing with or of any Governmental Entity or other Person isrequired to be done or obtained by the Seller in connection with (i) the execution and delivery by the Seller of this Agreement, (ii) the performance by theSeller of its obligations under this Agreement or (iii) the consummation by the Seller of any of the transactions contemplated by this Agreement. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.4(f) No Litigation. There is no action, suit, investigation or proceeding pending before any Governmental Entity or, to the Knowledge of theSeller, threatened to which the Seller is a party that, individually or in the aggregate would, if determined adversely, reasonably be expected to prevent oradversely affect (i) the ability of the Seller to enter into and to perform its obligations under this Agreement, (ii) the Seller’s rights under the LicenseAgreement or (iii) after the Closing, the Buyer’s rights with respect to the Purchased Royalty.(g) Compliance with Laws. The Seller is not in violation of, and to the Knowledge of the Seller, the Seller is not under investigation with respectto nor has the Seller been threatened to be charged with or given notice of any violation of, any law or Judgment applicable to the Seller, which violationwould reasonably be expected to adversely affect the Seller’s rights under the License Agreement or, after the Closing, the Buyer’s rights with respect to thePurchased Royalty hereunder.(h) License Agreement. The License Agreement has been Delivered by the Seller and is a true, correct and complete copy of the LicenseAgreement. As of the date hereof, Licensee has not sent, and the Seller has not received, any payments payable by Licensee to the Seller pursuant toSection 13.4 of the License Agreement.(i) No Other Agreements. Except as set forth on Schedule 3.1(h)(i) of the Disclosure Schedule, the License Agreement is the onlyagreement, instrument, arrangement, waiver or understanding between the Seller (or any predecessor or Affiliate thereof), on the one hand, andLicensee (or any predecessor or Affiliate thereof), on the other hand, relating to the subject matter thereof, and there are no other agreements,instruments, arrangements, waivers or understandings between the Seller (or any predecessor or any Affiliate thereof), on the one hand, andLicensee (or any predecessor or Affiliate thereof), on the other hand, that relate to the License Agreement, the Licensed Patents, the LicenseePatents, the Compounds (including the Development or Commercialization thereof) or the Royalty. A true, correct and complete copy of each ofthe agreements, instruments, arrangements or understandings set forth on Schedule 3.1(h)(i) of the Disclosure Schedule has been Delivered by theSeller prior to the date hereof. The Licensee Security Agreement Delivered by the Seller is a true, correct and complete copy of the LicenseeSecurity Agreement and has terminated by its terms. Except as set forth on Schedule 3.1(h)(i) of the Disclosure Schedule, the Seller has notproposed or received any proposal, to amend or waive any provision of the License Agreement with respect to the Licensed Patents, LicenseePatents, the Compounds in development under the License Agreement or the Royalty. The License Agreement has not been modified byLicensee or the Seller pursuant to Section 18.8.4 of the License Agreement.(ii) Licenses/Sublicenses. Except as set forth on Schedule 3.1(h)(ii) of the Disclosure Schedule, to the Knowledge of the Seller, there are nolicenses or sublicenses entered into by Licensee or any other Person (or any predecessor or Affiliate thereof) in respect of Licensee’s rights andobligations under the License Agreement (including any Intellectual Property), including pursuant to Section 9.6 of the License Agreement. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.5(iii) Validity and Enforceability of Agreements. The License Agreement is a valid and binding obligation of the Seller and Licensee. TheLicense Agreement is enforceable against each of the parties thereto in accordance with its terms, except as may be limited by applicableBankruptcy Laws or by general principles of equity (whether considered in a proceeding in equity or at law). The Seller has not received anynotice in connection with the License Agreement challenging the validity, enforceability or interpretation of any provision of such agreement,including the obligation to pay any portion of the Royalty without set-off of any kind.(iv) CK-452. CK-452 is being developed as a [ * ]. Pursuant to the License Agreement, Licensee is obligated to pay royalties on Net Salesof CK-452 and any other Compound. [ * ].(v) No Liens or Assignments by the Seller. Except as set forth in Schedule 3.1(h)(v) of the Disclosure Schedule, the Seller has not, except ascontemplated hereby, conveyed, assigned or in any other way transferred or granted any liens upon or security interests with respect to all or anyportion of its right, title and interest in and to the Royalty, the Intellectual Property, the Compounds or the License Agreement.(vi) No Termination. The Seller has not (A) given Licensee any notice of termination of the License Agreement (whether in whole or inpart) or any notice expressing any intention or desire to terminate the License Agreement or (B) received any notice of termination of the LicenseAgreement (whether in whole or in part) or any notice expressing any intention or desire to terminate either the License Agreement. To theKnowledge of the Seller, no event has occurred that would give rise to the expiration of the License Agreement.(vii) No Breaches or Defaults. There is and has been no material breach or default under any provision of the License Agreement either bythe Seller (or any predecessor thereof) or, to the Knowledge of the Seller, by Licensee (or any predecessor thereof), and there is no event thatupon notice or the passage of time, or both, would reasonably be expected to give rise to any material breach or default either by the Seller or, tothe Knowledge of the Seller, by the other party to the License Agreement.(viii) Payments Made. The Seller has received from Licensee the full amount of the payments due and payable under Sections 13.1 and13.2 of the License Agreement, the Phase III Initiation Milestone Event for a [ * ] under Section 13.3.1 of the License Agreement andSection 2(d) of Amendment No. 6. To the Knowledge of the Seller, other than such payments and any payments for FTEs (as such term is definedin the License Agreement) made pursuant to Section 13.6 of the License Agreement, payments for transfer of materials and reimbursement ofcosts as otherwise agreed by Licensee, the Seller has received no other payments under the License Agreement. All such payments were made byLicensee to the Seller without any Royalty Reduction and, in all material respects, when due. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.6(ix) No Assignments by Licensee. Except for the sublicense granted pursuant to that certain Option, License and Collaboration Agreementamong Licensee and Les Laboratoires Servier and Institut de Recherches Internationales Servier (the “Sublicensee”), dated as of June 27, 2013(the “Existing Sublicense”), the Seller has not been notified of any assignment or other transfer by Licensee of any of its rights or obligationsunder the License Agreement, and to the Knowledge of the Seller, other than to the Sublicensee, Licensee has not sublicensed, assigned orotherwise transferred any of its rights or obligations under the License Agreement to any Person.(x) No Indemnification Claims. The Seller has not notified Licensee or any other Person of any claims for indemnification under theLicense Agreement nor has the Seller received any claims for indemnification under the License Agreement, whether pursuant to Article 17thereof or otherwise.(xi) No Royalty Reductions. To the Knowledge of the Seller, the amount of the Royalty is not subject to any claim against the Sellerpursuant to any right of set-off, counterclaim, credit, reduction or deduction by contract or otherwise pursuant to the License Agreement,including Sections 8.8, 8.9, [ * ] and [ * ] of the License Agreement (a “Royalty Reduction”). To the Knowledge of the Seller, no event orcondition exists that, upon notice or passage of time or both, would reasonably be expected to permit Licensee to claim, or have the right toclaim, a Royalty Reduction.(xii) Audits. The Seller has not initiated, pursuant to Section 13.11 of the License Agreement or otherwise, any inspection or audit ofbooks of accounts or other records pertaining to Net Sales, the calculation of royalties or other amounts payable to the Seller under the LicenseAgreement.(xiii) Options. Licensee duly exercised, and has not sought to revoke its exercise of, the Licensee Option. A true, correct and completecopy of the notice of such exercise of the Licensee Option has been Delivered by the Seller to Buyer. The Seller has as of the date hereofprovided to Licensee notice of the Seller’s decision to exercise the Co-Invest Option with respect to CK-452 for $10,000,000 pursuant to theterms of the License Agreement. The Seller has not sought to revoke its exercise of such Co-Invest Option. A true, correct and complete copy ofthe notice of such exercise of the Co-Invest Option has been Delivered by the Seller to Buyer.(xiv) Subject Transactions. Neither the Seller nor Licensee has undergone a Subject Transaction. The Seller has not received any noticefrom Licensee of Licensee’s contemplation or intent to undergo a Subject Transaction and the Seller has not sent any notice to Licensee of theSeller’s contemplation or intent to undergo a Subject Transaction. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.7(i) Title to Royalty. The Seller has good and marketable title to the Royalty free and clear of all Liens (other than Permitted Liens). Uponpayment of the Purchase Price by the Buyer, the Buyer shall have acquired, subject to the terms and conditions set forth in this Agreement and the LicenseAgreement, good and marketable title to the Purchased Royalty, free and clear of all Liens (other than Liens created by the Buyer).(j) Intellectual Property. Schedule 3.1(j) has been Delivered by the Seller to Buyer’s counsel.(i) Schedule 3.1(j)(i)(A) and (B) of the Disclosure Schedule lists all of the Licensed Patents with respect to the Compounds in Developmentor Commercialization under the License Agreement as of the date of this Agreement (the “Existing In-Development Patents”). The Seller is thesole owner of, and has the sole interest in, all of the Existing In-Development Patents listed in Schedule 3.1(j)(i)(A) under the heading “Solely-Owned Patents” and is the joint owner with Licensee of all of the Existing In-Development Patents listed in Schedule 3.1(j)(i)(B) under theheading “Joint Patent Rights”. Except as set forth on Schedule 3.1(j)(i), (x) to the Knowledge of the Seller, the Seller and Licensee collectivelyare the sole owners of, and collectively have the sole interest in, the Joint Patent Rights with respect to the Compounds in Development orCommercialization under the License Agreement as of the date of this Agreement, and (y) to the Knowledge of the Seller, each of the Seller andLicensee have an undivided one-half interest in each of the Joint Patent Rights with respect to the Compounds in Development orCommercialization under the License Agreement as of the date of this Agreement, and (z) the Seller is the sole owner of, and has the sole interestin, its undivided half interest in each of the Joint Patent Rights with respect to the Compounds in Development or Commercialization under theLicense Agreement as of the date of this Agreement. Schedule 3.1(j)(i)(C) of the Disclosure Schedule contains a true, correct and complete copyof the most recent list of Licensee Patents with respect to the Compounds in Development or Commercialization under the License Agreement asof the date of this Agreement. Schedule 3.1(j)(i) of the Disclosure Schedule specifies as to each of the Existing In-Development Patents andLicensee Patents with respect to the Compounds in Development or Commercialization under the License Agreement as of the date of thisAgreement, as applicable, the jurisdictions by or in which each such patent right has issued as a patent or a patent application has been filed,including the respective application numbers.(ii) Except as set forth in Schedule 3.1(j)(ii) of the Disclosure Schedule, there are no pending or, to the Knowledge of the Seller, threatenedlitigations, interferences, reexamination, oppositions or like procedures involving any Licensed Patent. Except as set forth in Schedule 3.1(j)(ii)of the Disclosure Schedule, to the Knowledge of the Seller, there are no pending or threatened litigations, interferences, reexamination,oppositions or like procedures involving any Licensee Patent. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.8(iii) All of the issued Licensed Patents are in full force and effect and have not lapsed, expired or otherwise terminated. Except as set forthin Schedule 3.1(j)(iii) of the Disclosure Schedule, to the Knowledge of the Seller, the issued Existing In-Development Patents are valid andenforceable. The Seller has not received any written notice relating to the lapse, expiration or other termination of any of the Licensed Patents orany written legal opinion that alleges that any of the issued Licensed Patents is invalid or unenforceable. The Seller has not received any noticefrom Licensee indicating that any of the issued Licensee Patents are not in full force and effect or have lapsed, expired or otherwise terminated.The Seller has not received any notice from Licensee indicating that Licensee has received any written notice relating to the lapse, expiration orother termination of any of the Licensee Patents or any written legal opinion that alleges that any of the issued Licensee Patents is invalid orunenforceable. To the Knowledge of Seller, Seller and Licensee have complied in all respects with the duty of candor and good faith, whichincludes the duty of disclosure under 37 C.F.R. § 1.65, in the prosecution of the Existing In-Development Patents before the U.S. Patent andTrademark Office.(iv) There is no Person who is or claims to be an inventor under any of the Existing In-Development Patents who is not a named inventorthereof. To the Knowledge of the Seller, there is no Person who is or claims to be an inventor under any of the Licensee Patents with respect tothe Compounds in Development or Commercialization under the License Agreement as of the date of this Agreement who is not a namedinventor thereof.(v) The Seller has not received any written notice of any claim by any Person regarding a challenge of inventorship or ownership of, therights of the Seller in and to, or the patentability, validity or enforceability of, any Licensed Patent, or asserting that the development,manufacture, importation, sale, offer for sale or use of any Compound infringes any patent or other intellectual property rights. The Seller has notreceived any notice from Licensee indicating that Licensee has received any written notice of any claim by any Person regarding a challenge ofinventorship or ownership of, the rights of the Seller or Licensee in and to, or the patentability, validity or enforceability of, any Licensed Patent,or asserting that the development, manufacture, importation, sale, offer for sale or use of any Compound infringes any Third Party patent or otherintellectual property rights.(vi) The Seller has not received any written notice from Licensee or any other Person, or given any written notice to, Licensee stating that aThird Party asserts that a Patent Right or other right owned by it is infringed by the manufacture, use, sale, offer for sale or import of anyCompound in the Territory or otherwise. To the Knowledge of the Seller, no intellectual property rights of any Third Party have been, or are orshall be infringed, violated or misused by the manufacture, use, offer for sale, importation, sale or import of CK-452. There are no Known PatentClaims (as defined in the License Agreement). Except as set forth in Schedule 3.1(j)(vi), the Seller has not in-licensed any intellectual property [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.9right covering the manufacture, use, sale, offer for sale or import of CK-452. That Exclusive License Agreement between The Regents of theUniversity of California, The Board of Trustees of the Leland Stanford Junior University and the Seller, dated as of April 21, 1998, as modifiedSeptember 1, 2000, is terminated and of no further force or effect and none of the patents or other intellectual property rights previously licensedto the Seller thereunder included any Patent Rights or know-how right the scope of which would cover the making, using, selling, offering forsale or import of any Compound.(vii) To the Knowledge of the Seller, except set forth in Schedule 3.1(j)(vii) of the Disclosure Schedule, and except for activities conductedby the Licensee in accordance with the License Agreement or Sublicensee in accordance with Existing Sublicense, no Third Party is making,using, selling, offering for sale, importing or exporting a product that infringes any Licensed Patent or any other patent right (including anyLicensee Patent) that contains any claim the scope of which would cover the making, using, selling, offering for sale or import of anyCompound.(viii) All required maintenance fees, annuities and like payments with respect to the Licensed Patents have been paid timely.(k) UCC Representation and Warranties. The Seller’s exact legal name is, and for the immediately preceding ten years has been, “Cytokinetics,Incorporated”. The Seller is, and for the prior ten years has been, incorporated in the State of Delaware.(l) Brokers’ Fees. Except as set forth in Schedule 3.1(l) of the Disclosure Schedule, there is no investment banker, broker, finder, financial advisoror other intermediary who has been retained by or is authorized to act on behalf of the Seller who might be entitled to any fee or commission in connectionwith the transactions contemplated by this Agreement.(m) Term Loan Facility. The Seller is in material compliance with all of its obligations under the Term Loan Facility.Section 3.2 The Buyer’s Representations and Warranties. The Buyer represents and warrants to the Seller that as of the date hereof:(a) Existence; Good Standing. The Buyer is a statutory trust duly organized, validly existing and in good standing under the laws of the State ofDelaware.(b) Authorization. The Buyer has the requisite trust right, power and authority to execute, deliver and perform its obligations under thisAgreement. The execution, delivery and performance of this Agreement, and the consummation of the transactions contemplated hereby, have been dulyauthorized by all necessary action on the part of the Buyer. Wilmington Trust is duly authorized to execute and deliver this Agreement on behalf of Buyer. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.10(c) Enforceability. This Agreement has been duly executed and delivered by an authorized person of the owner trustee of the Buyer andconstitutes the valid and binding obligation of the Buyer, enforceable against the Buyer in accordance with its terms, except as may be limited by applicableBankruptcy Laws or by general principles of equity (whether considered in a proceeding in equity or at law).(d) No Conflicts. The execution, delivery and performance by the Buyer of this Agreement do not and shall not (i) contravene or conflict with theorganizational documents of the Buyer, (ii) contravene or conflict with or constitute a default under any material provision of any law binding upon orapplicable to the Buyer or (iii) contravene or conflict with or constitute a default under any material contract or other material agreement or Judgmentbinding upon or applicable to the Buyer.(e) Consents. No consent, approval, license, order, authorization, registration, declaration or filing with or of any Governmental Entity or otherPerson is required to be done or obtained by the Buyer in connection with (i) the execution and delivery by the Buyer of this Agreement, (ii) the performanceby the Buyer of its obligations under this Agreement, other than the filing of financing statement(s) in accordance with Section 1.4, or (iii) the consummationby the Buyer of any of the transactions contemplated by this Agreement.(f) No Litigation. There is no action, suit, investigation or proceeding pending or, to the knowledge of the Buyer, threatened before anyGovernmental Entity to which the Buyer is a party that would, if determined adversely, reasonably be expected to prevent or materially and adversely affectthe ability of the Buyer to perform its obligations under this Agreement.(g) Financing. The Buyer has sufficient cash on hand to pay the entire Purchase Price. The Buyer acknowledges that its obligations under thisAgreement are not contingent on obtaining financing.(h) Brokers’ Fees. There is no investment banker, broker, finder, financial advisor or other intermediary who has been retained by or is authorizedto act on behalf of the Buyer who might be entitled to any fee or commission in connection with the transactions contemplated by this Agreement.Section 3.3 No Implied Representations and Warranties. EXCEPT AS EXPRESSLY SET FORTH IN SECTION 3.1, THE SELLER MAKES NOREPRESENTATION OR WARRANTY, EXPRESSED OR IMPLIED, AT LAW OR IN EQUITY IN RESPECT OF THE LICENSE AGREEMENT, ANYLICENSED PATENTS, THE PURCHASED ROYALTY, THE ROYALTY OR THE TRANSACTIONS CONTEMPLATED HEREBY, INCLUDING WITHRESPECT TO MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE, AND ANY SUCH OTHER REPRESENTATIONS ORWARRANTIES ARE HEREBY EXPRESSLY DISCLAIMED. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.11ARTICLE 4CONDITIONS TO CLOSINGSection 4.1 Conditions to the Buyer’s Obligations. The obligations of the Buyer to consummate the transactions contemplated hereunder on theClosing Date are subject to the satisfaction or waiver, at or prior to the Closing Date, of each of the following conditions precedent:(a) The Seller shall have performed and complied in all material respects with all agreements, covenants, obligations and conditions required tobe performed and complied by it under this Agreement at or prior to the Closing Date, and the Buyer shall have received a certificate executed by a dulyauthorized officer of the Seller on the Closing Date certifying on behalf of the Seller to the effect of the foregoing.(b) The representations and warranties of the Seller contained in Section 3.1 shall be true and correct in all material respects as of the ClosingDate as though made at and as of the Closing Date, except to the extent any such representation or warranty expressly speaks as of a particular date, in whichcase it shall be true and correct in all material respects as of such date; provided, that to the extent that any such representation or warranty is qualified by theterm “material,” such representation or warranty (as so written, including the term “material”) shall be true and correct in all respects as of the Closing Date orsuch other date, as applicable, and the Buyer shall have received a certificate executed by an authorized person of the owner trustee of the Seller on theClosing Date certifying on behalf of the Seller to the effect of the foregoing.(c) There shall not have been issued and be in effect any Judgment of any Governmental Entity enjoining, preventing or restricting theconsummation of the transactions contemplated by this Agreement.(d) There shall not have been instituted or be pending any action or proceeding by any Governmental Entity or any other Person (i) challengingor seeking to make illegal, to delay materially or otherwise directly or indirectly to restrain or prohibit the consummation of the transactions contemplatedhereby, (ii) seeking to obtain material damages in connection with the transactions contemplated hereby or (iii) seeking to restrain or prohibit the Buyer’sreceipt of the Purchased Royalty.(e) The Seller shall have delivered to the Buyer the duly executed Bill of Sale, Stock Purchase Agreement and Lender Consent.(f) The Buyer shall have received the closing certificate(s) of the Seller as provided by Section 2.3(a).(g) The Licensee Consent Delivered by the Seller shall have been duly executed by the Seller and Licensee.(h) At the Closing, the Seller shall deliver to Buyer an opinion of the Seller’s counsel, dated as of the Closing Date in form and substancereasonably acceptable to Buyer.(i) All conditions to the consummation of the transactions under the Stock Purchase Agreement shall have been satisfied, except for suchconditions as will, by their terms, be satisfied simultaneous with such consummation and except for the occurrence of the Closing. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.12Section 4.2 Conditions to the Seller’s Obligations. The obligations of the Seller to consummate the transactions contemplated hereunder on theClosing Date are subject to the satisfaction or waiver, at or prior to the Closing Date, of each of the following conditions precedent:(a) The Buyer shall have performed and complied in all material respects with all agreements, covenants, obligations and conditions required tobe performed and complied by it under this Agreement at or prior to the Closing Date, and the Seller shall have received a certificate executed by a dulyauthorized representative of the Buyer on the Closing Date certifying on behalf of the Buyer to the effect of the foregoing.(b) The representations and warranties of the Buyer contained in Section 3.2 shall be true and correct in all material respects as of the ClosingDate as though made at and as of the Closing Date, except to the extent any such representation or warranty expressly speaks as of a particular date, in whichcase it shall be true and correct in all material respects as of such date; provided, that to the extent that any such representation or warranty is qualified by theterm “material,” such representation or warranty (as so written, including the term “material”) shall be true and correct in all respects as of the Closing Date orsuch other date, as applicable, and the Buyer shall have received a certificate executed by a duly authorized officer of the Buyer on the Closing Datecertifying on behalf of the Buyer to the effect of the foregoing.(c) There shall not have been issued and be in effect any Judgment of any Governmental Entity enjoining, preventing or restricting theconsummation of the transactions contemplated by this Agreement.(d) There shall not have been instituted or be pending any action or proceeding by any Governmental Entity or any other Person (i) challengingor seeking to make illegal, to delay materially or otherwise directly or indirectly to restrain or prohibit the consummation of the transactions contemplatedhereby, (ii) seeking to obtain material damages in connection with the transactions contemplated hereby or (iii) seeking to restrain or prohibit the Buyer’sreceipt of the Purchased Royalty.(e) The Seller shall have received the closing certificate of the Buyer as provided by Section 2.3(b).(f) The Buyer shall have delivered to the Seller the duly executed Stock Purchase Agreement.(g) All conditions to the consummation of the transactions under the Stock Purchase Agreement shall have been satisfied, except for suchconditions as will, by their terms, be satisfied simultaneous with such consummation and except for the occurrence of the Closing. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.13ARTICLE 5COVENANTSSection 5.1 Disclosures; Update.(a) The parties shall agree upon the Press Release to be issued announcing this Agreement. Except for the Press Release, the Current Report onForm 8-K describing the material terms of the Agreement and the transaction contemplated by the Agreement or any other public announcement usingsubstantially the same text as such press release or Form 8-K, neither the Buyer nor the Seller shall, and each party hereto shall cause its respectiveRepresentatives, Affiliates and Affiliates’ Representatives not to, issue a press release or other public announcement or otherwise make any public disclosurewith respect to this Agreement or the subject matter hereof without the prior written consent of the other party hereto (which consent shall not beunreasonably withheld or delayed), except as may be required by applicable law or stock exchange rule (in which case the party hereto required to make thepress release or other public announcement or disclosure shall allow the other party hereto reasonable time to comment on such press release or other publicannouncement or disclosure in advance of such issuance); provided that no review or consent shall be required with respect to disclosures by either party ofthe Agreement and the transaction in such party’s periodic reports filed with the Securities and Exchange Commission or of disclosures otherwise previouslyapproved pursuant to this Section 5.1(a).(b) During the Royalty Term, Seller shall provide semi-annually a list in the form of Schedule 3.1(j)(i) to Buyer’s counsel of all Licensed Patentscovering Compounds in Development or Commercialization under the License Agreement as of such date.Section 5.2 Payments Received In Error; Payment Deferral; Interest Payments. If any payment of the Purchased Royalty is made to the Seller, theSeller shall pay over to the Buyer, promptly (and in any event within [ * ] after the receipt thereof, the amount of such payment received by wire transfer to anaccount designated in writing by the Buyer. The Seller agrees that, in the event any payment of the Purchased Royalty is paid to the Seller, the Seller shall(i) until paid to the Buyer, hold such payment received in trust for the benefit of the Buyer and (ii) have no right, title or interest in such payment and that itshall not pledge or otherwise grant any security interest therein. If the Licensee defers payment of the Purchased Royalty in accordance with Exhibit B to theLicensee Consent because of its uncertainty as to the amount of such payment to which the Buyer is entitled, then Buyer and Seller shall promptly meet anddiscuss in good faith the preparation and delivery of joint instructions from the parties to Licensee to make such payments that have been deferred. If a sumpayable under this Agreement shall be overdue for [ * ], the party obligated to make such payment shall additionally pay to the party to whom such paymentis owed interest on the sum outstanding at the rate equal to the lesser of (i) prime rate for the date that payment was due, as published by The Wall StreetJournal, Eastern U.S. edition, plus [ * ]; and (ii) the highest rate permitted by law shall apply; provided that a delay in payment by Licensee of any payment tothe Buyer (other than a delay as a result of any act or failure to act by the Seller) shall not be deemed an overdue payment by the Seller to the Buyer. Thepayment of such interest shall not prevent the party to whom such payment is made from exercising any other rights it may have as a consequence of thelateness of any payment. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.14Section 5.3 Royalty Reduction. If Licensee exercises any right of set-off, counterclaim, credit, reduction or deduction by contract or otherwiseagainst any payment of the Royalty, such set-off, counterclaim, credit, reduction or deduction shall not reduce the applicable amount of the PurchasedRoyalty otherwise payable to Buyer, and if such set-off, counterclaim, credit, reduction or deduction reduces the Royalty payable under the LicenseAgreement to less than the full amount of the Purchased Royalty, then Seller shall promptly (and in any event within [ * ] following the payment of thePurchased Royalty affected by such set-off, counterclaim, credit, reduction or deduction) make a true-up payment to Buyer such that Buyer receives the fullamount of such Purchased Royalty payments that would be payable for the Purchased Royalty had such set-off, counterclaim, credit, reduction or deductionnot occurred.Section 5.4 Royalty Reports; Other Information; Notices; Update Meetings.(a) Promptly after receipt by the Seller of (i) notice from the Buyer that the Buyer has not received any Royalty Report for a Compound withrespect to which Net Sales have been made or (ii) any other notice, correspondence or report (other than any of [ * ]) provided by Licensee under the LicenseAgreement related to the Royalty, Licensed Patents claiming or covering any Compound in Development or Commercialization, the Licensee Patentsclaiming or covering any Compound in Development or Commercialization, or Compounds in Development or being Commercialized, the Seller shallprovide or shall cause to be provided to the Buyer, a copy of such Royalty Report, notice, correspondence or other report. For clarity, disclosure or access toany patent documentation, including notices, correspondence or reports provided hereunder related to the Licensed Patents or Licensee Patents, shall belimited to Buyer’s counsel to the extent required under the Licensee Consent.(b) The Seller shall not send any written correspondence to Licensee that would reasonably be expected to result in a Material Adverse Effectwithout the prior written consent of the Buyer. Following the reasonable request of the Buyer, the Seller shall promptly send to Licensee notices orcorrespondence related to the Royalty or any Compound in Development or Commercialization as requested by the Buyer.(c) Once during each calendar quarter from and after the Closing Date (other than any calendar quarter in which an Annual Update Meetingoccurs), the Buyer Representatives and the Seller Representatives shall have a telephonic meeting (each a “Quarterly Update Meeting”) to discuss materialdevelopments in the development and commercialization of the Compounds then in Development or being Commercialized by Licensee (other than any of [* ]) and the Seller since the Closing or the last Quarterly Update Meeting. Once during each twelve (12)-month period from and after the Closing Date, theBuyer Representatives and the Seller Representative shall meet in person at the Seller’s offices or such other place as the Seller and the Buyer mutually agree(each an “Annual Update Meeting”) to discuss material developments in the development and commercialization of the Compounds then in Development orCommercialization by Licensee (other than any of [ * ]) and Seller since the Closing or the last Annual Update Meeting. Each of the Buyer and the Sellershall bear its own costs and expenses related to such meetings and Buyer acknowledges that the receipt of information from such meetings shall bemaintained as confidential pursuant to this Agreement and may include material, non-public information which prohibits trading while in possession of ormisuse of such information under applicable securities laws. For clarity, disclosure or access to any patent documentation, including notices, correspondenceor reports provided hereunder related to the Licensed Patents or Licensee Patents, shall be limited to Buyer’s counsel to the extent required under theLicensee Consent. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.15(d) Seller shall use commercially reasonable efforts to respond to any reasonable inquiries of the Buyer related to the Royalty or to anyCompound then in Development or being Commercialized under the License Agreement and shall promptly provide any additional development andcommercialization information related thereto (other than any of [ * ]) reasonably requested by the Buyer. For clarity, disclosure and access to any patentdocumentation, including correspondence or reports provided hereunder related to the Licensed Patents or Licensee Patents, shall be limited to Buyer’scounsel to the extent required under the Licensee Consent.Section 5.5 Inspections and Audits of Licensee. At the written request of the Buyer, the Seller shall, to the extent permitted under Section 13.11of the License Agreement, cause an inspection or audit by an independent public accounting firm to be made for the purpose of determining the correctnessof royalty payments with respect to the Compounds made under the License Agreement. With respect to any such inspection, the Seller shall, for purposesSection 13.11 of the License Agreement, select such independent public accounting firm as the Buyer shall recommend and is reasonably acceptable to theSeller for such purpose (as long as such independent certified public accountant is reasonably acceptable to Licensee as required by Section 13.11 of theLicense Agreement). All of the expenses of any inspection or audit requested by the Buyer hereunder (including the fees and expenses of such independentpublic accounting firm designated for such purpose) that would otherwise be borne by the Seller pursuant to the License Agreement shall instead be borne (ifand as such expenses are incurred) by the Buyer and the Seller according to their Pro-Rata Share.Section 5.6 Amendment of License Agreement. The Seller shall not, without the Buyer’s prior written consent, execute or agree to execute anyalteration, amendment, change or addition (a “Modification”) of or to any provision of the License Agreement that would reasonably be expected to result ina Material Adverse Effect. Subject to the foregoing, promptly, and in any event within five (5) Business Days, following receipt by the Seller of a fullyexecuted Modification to the License Agreement related to the Licensed Patents, Licensee Patents, Compounds or Royalty, the Seller shall furnish a copy ofsuch Modification to the Buyer.Section 5.7 Maintenance of License Agreement; Efforts to Commercialize.(a) The Seller shall comply in all material respects with its obligations under the License Agreement related to the Licensed Patents, LicenseePatents, Compounds and Royalty and shall not take any action or forego any action that would reasonably be expected to result in a Material Adverse Effect.Promptly, and in any event within [ * ], after receipt of any (written or oral) notice from Licensee of an alleged material breach by the Seller (pursuant toSection 18.5 of the License Agreement or otherwise), the Seller shall give notice thereof to the Buyer, including delivering the Buyer a copy of any suchwritten notice. The Seller shall use its commercially reasonable efforts to cure any breaches by it under the License Agreement and shall give written notice tothe Buyer upon curing any such breach. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.16(b) The Seller hereby agrees to use its commercially reasonable efforts to take, or cause to be taken, all actions and to do, or cause to be done, allthings reasonably necessary to obligate Licensee to Commercialize CK-452 and in good faith to consider Commercialization of any other Compounds inaccordance with the terms of the License Agreement.Section 5.8 Enforcement of License Agreement.(a) Notice of Breaches by Licensee. Promptly (and in any event within five (5) Business Days) after the Seller becomes aware of, or comes tobelieve in good faith that there has been, a breach of the License Agreement by Licensee that could reasonably be expected to result in a Material AdverseEffect, the Seller shall provide notice of such breach to the Buyer. In addition, the Seller shall provide to the Buyer a copy of any written notice of breach oralleged breach of the License Agreement delivered by the Seller to Licensee as soon as practicable and in any event not less than five (5) Business Daysfollowing such delivery.(b) Enforcement of License Agreement. In the case of any breach by Licensee referred to in Section 5.8(a), the Seller shall consult with the Buyerregarding the timing, manner and conduct of any enforcement of Licensee’s obligations under the License Agreement. The Seller may and, if requested inwriting by the Buyer, [ * ].(c) Allocation of Proceeds and Costs of Enforcement. All costs and expenses (including attorneys’ fees and expenses) of any enforcementpursuant to Section 5.8(b), shall be borne by the Buyer and Seller in accordance with each party’s Pro-Rata Share. The Proceeds resulting from anyenforcement of Licensee’s obligations under the License Agreement undertaken pursuant to Section 5.8(b), after deduction of all costs and expenses(including attorneys’ fees and expenses) actually incurred by the Buyer or Seller in connection with such enforcement, shall be paid to the Buyer and Sellerin accordance with each party’s Pro-Rata Share. The Buyer and Seller shall fund, each in accordance with its respective Pro-Rata Share, any retainers,advances, and regular invoices required or sent by the counsel employed for such enforcement (such amounts to be credited or deducted from the actualamounts owed by the either Buyer or Seller under the immediately preceding sentence) and each party shall reimburse the other party for such party’s costs orexpenses that are not satisfied out of the Proceeds of such enforcement and are in excess of such party’s Pro-Rata Share. Nothing contained herein shall limitthe Buyer from retaining, at its expense, separate outside counsel who shall be permitted, where reasonably practical, to consult with the lead counselselected by the Seller for such enforcement.Section 5.9 Termination of License Agreement; Seller Product Opportunity.(a) The Seller shall not exercise any right to terminate the License Agreement, or agree with Licensee to terminate the License Agreement, exceptwith the prior written consent of the Buyer.(b) If Licensee terminates the License Agreement pursuant to Section 18.2 thereof or otherwise, then the Seller shall (i) as permitted under theLicense Agreement, request from Licensee all of the rights in the Program and license(s) contemplated by Section 18.3 of the [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.17License Agreement, (ii) use commercially reasonable efforts to maintain the Existing Sublicense in effect and (iii) continue to use commercially reasonableefforts to Commercialize the Compounds, which may include licensing or otherwise transferring the Program to a new biopharmaceutical enterprise.Following any such termination, the Seller (or upon the request of the Buyer, the Seller’s licensee or transferee, if applicable) shall enter into an agreementwith the Buyer to preserve the Buyer’s rights under this Agreement, including the Buyer’s rights in and to the Purchased Royalty, mutatis mutandis, in anysubsequent license agreement with respect to any Compound to be Commercialized by a Third Party or in connection with direct sales by the Seller of anyCompound. If certain of Licensee’s rights under the License Agreement are terminated in connection with the terms of the Letter Agreement but Sellerreceives royalties from a Third Party or sells directly any Compound that is to be Commercialized, the Seller shall (i) in the case of a license to a Third Party,provide in the agreement with such Third Party that the Buyer shall be entitled to substantially the same rights to payment from such Third Party as the Buyerhad from Licensee under this Agreement prior to such termination and (ii) in the case of direct sales by the Seller, the Seller shall pay to the Buyer theamounts to which Buyer would have been entitled from a Third Party if the Seller had instead entered into an agreement with a Third Party.(c) If the Seller identifies any CK Product Opportunity in respect of a Compound, then the Seller shall promptly notify the Buyer thereof and theSeller shall enter into an agreement with the Buyer to preserve the Buyer’s rights under this Agreement, including the Buyer’s rights in and to the PurchasedRoyalty, mutatis mutandis, in respect of such CK Product Opportunity, whether under any subsequent license agreement or in respect of direct sales by theSeller.Section 5.10 Preservation of Rights. The Seller shall not hereafter sell, transfer, hypothecate, assign or in any manner convey or mortgage, pledgeor grant a security interest or other encumbrance of any kind in any of its interest in any portion of the Licensed Patents or the License Agreement, if suchaction is would reasonably be expected to result in a Material Adverse Effect.Section 5.11 Enforcement; Infringement Claims. The Seller shall promptly inform the Buyer of (x) any actual and continuing infringement ofany of the Licensed Patents or any other Patent Right covering Compounds then in Development or being Commercialized under the License Agreement ofwhich Seller becomes aware arising from the making, using, selling, offering for sale or import of any compound by a Third Party, in any case where suchinfringement would reasonably be expected to result in a Material Adverse Effect, or (y) any Third Party patent right of which Seller becomes aware that theuse, sale, offer for sale or import that any Compound then in Development or being Commercialized under the License Agreement infringes where suchinfringement would reasonably be expected to result in a Material Adverse Effect. Buyer and the Seller agree to enter into a joint defense and/or commoninterest agreement in customary form promptly after learning of any of the matters contemplated by the preceding sentence. After entering into such jointdefense and/or common interest agreement, the Seller shall provide to Buyer’s counsel a copy of any written notice of any suspected infringement of any ofthe Licensed Patents or any other Patent Right (including the Licensee Patents) delivered under Section 21.12 of the License Agreement or otherwise as soonas practicable and in any event not less than five (5) Business Days following entry into such joint defense and/or common interest agreement. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.18(a) If the Seller has the right to initiate an enforcement action as set forth in Section 8.10 of the License Agreement and if such infringementwould have a Material Adverse Effect, then if requested in writing by the Buyer, Seller shall promptly, and in any event within five (5) Business Days afterreceipt of such request, exercise such right, as reasonably instructed by the Buyer and, if requested by the Buyer, the Seller shall employ such counselreasonably acceptable to the Seller as the Buyer shall recommend for such purpose.(b) The Seller shall agree to assign to the Buyer its Pro-Rata Share of recoveries recovered in respect of any enforcement action underSection 8.10 of the License Agreement and allocated to the Seller thereunder (after deduction of any costs and expenses (including attorneys’ fees andexpenses) incurred by the Seller in connection with any such action). All costs and expenses (including attorneys’ fees and expenses) incurred by the Seller inconnection with any enforcement action pursuant to the License Agreement (other than any costs and expenses of the Seller that are satisfied out of theamounts recovered in such enforcement) shall be borne by the Buyer and the Seller in accordance with each party’s respective Pro-Rata Share. Each of theBuyer and the Seller shall (i) fund any retainers or advances required by the counsel employed by the Seller for any such enforcement (such amounts to becredited or deducted from the actual amounts owed by the either party under the immediately preceding sentence) in accordance with such party’s Pro-RataShare and (ii) reimburse the other party for such party’s costs or expenses that are not satisfied out of the Proceeds of such enforcement and are in excess ofsuch party’s Pro-Rata Share. Nothing contained herein shall limit the Buyer from retaining, at its expense, separate outside counsel who shall be permitted,where reasonably practical, to consult with the lead counsel selected by the Seller for such enforcement. Prior to taking any actions pursuant to Sections 8.9or Section 8.10 of the License Agreement, including assuming the defense of any Third Party claims or consenting to the settlement of such claims, the Sellershall consult with the Buyer with respect to any such action, defense, settlement or consent.Section 5.12 Efforts to Consummate Transactions. Subject to the terms and conditions of this Agreement, each of the Seller and the Buyer shalluse its commercially reasonable efforts to take, or cause to be taken, all actions and to do, or cause to be done, all things reasonably necessary underapplicable law to consummate the transactions contemplated by this Agreement. Each of the Buyer and the Seller agrees to execute and deliver such otherdocuments, certificates, agreements and other writings and to take such other actions as may be reasonably necessary in order to consummate the transactionscontemplated by this Agreement.Section 5.13 [ * ].Section 5.14 Further Assurances. After the Closing, the Seller and the Buyer agree to execute and deliver such other documents, certificates,agreements and other writings and to take such other actions as may be reasonably necessary in order to give effect to the transactions contemplated by thisAgreement. The Seller shall, upon the written request of the Buyer, record and file, at the Buyer’s expense, financing statements (and continuation statements [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.19with respect to such financing statements when applicable) with respect to the Purchased Royalty meeting the requirements of applicable state law in suchmanner and in such jurisdictions as are necessary or appropriate to perfect the sale, transfer, assignment and conveyance of the Purchased Royalty to theBuyer.ARTICLE 6INDEMNIFICATIONSection 6.1 General Indemnity. Subject to Section 6.3, from and after the Closing:(a) the Seller hereby agrees to indemnify, defend and hold harmless the Buyer and its Affiliates and its and their directors, managers, trustees,officers, agents and employees (the “Buyer Indemnified Parties”) from, against and in respect of all Losses suffered or incurred by the Buyer IndemnifiedParties to the extent arising out of or resulting from (i) any breach of any of the representations or warranties (in each case, when made) of the Seller in thisAgreement and (ii) any breach of any of the covenants or agreements of the Seller in this Agreement; and(b) the Buyer hereby agrees to indemnify, defend and hold harmless the Seller and its Affiliates and its and their directors, officers, agents andemployees (the “Seller Indemnified Parties”) from, against and in respect of all Losses suffered or incurred by the Seller Indemnified Parties to the extentarising out of or resulting from (i) any breach of any of the representations or warranties (in each case, when made) of the Buyer in this Agreement or (ii) anybreach of any of the covenants or agreements of the Buyer in this Agreement.Section 6.2 Notice of Claims. If either a Buyer Indemnified Party, on the one hand, or a Seller Indemnified Party, on the other hand (such BuyerIndemnified Party on the one hand and such Seller Indemnified Party on the other hand being hereinafter referred to as an “Indemnified Party”), has sufferedor incurred any Losses for which indemnification may be sought under this Article 6, the Indemnified Party shall so notify the other party from whomindemnification is sought under this Article 6 (the “Indemnifying Party”) promptly in writing describing such Loss, the amount or estimated amount thereof,if known or reasonably capable of estimation, and the method of computation of such Loss, all with reasonable particularity and containing a reference to theprovisions of this Agreement in respect of which such Loss shall have occurred. If any claim, action, suit or proceeding is asserted or instituted by or againstLicensee or a Third Party with respect to which an Indemnified Party intends to claim any Loss under this Article 6, such Indemnified Party shall promptlynotify the Indemnifying Party of such claim, action, suit or proceeding and tender to the Indemnifying Party the defense of such claim, action, suit orproceeding. A failure by an Indemnified Party to give notice and to tender the defense of such claim, action, suit or proceeding in a timely manner pursuant tothis Section 6.2 shall not limit the obligation of the Indemnifying Party under this Article 6, except to the extent such Indemnifying Party is actuallyprejudiced thereby.Section 6.3 Limitations on Liability. No party hereto shall be liable for any consequential, punitive, special or incidental damages (and no claimfor indemnification hereunder shall be asserted) as a result of any breach or violation of any covenant or agreement of such party (including under this Article6) in or pursuant to this Agreement. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.20Section 6.4 Third Party Claims. Upon providing notice to an Indemnifying Party by an Indemnified Party pursuant to Section 6.2 of thecommencement of any action, suit or proceeding against such Indemnified Party by Licensee or a Third Party with respect to which such Indemnified Partyintends to claim any Loss under this Article 6, such Indemnifying Party shall have the right to defend such claim, at such Indemnifying Party’s expense andwith counsel of its choice reasonably satisfactory to the Indemnified Party. If the Indemnifying Party assumes the defense of such claim, the Indemnified Partyshall, at the request of the Indemnifying Party, use commercially reasonable efforts to cooperate in such defense; provided, that the Indemnifying Party shallbear the Indemnified Party’s reasonable out-of-pocket costs and expenses incurred in connection with such cooperation. So long as the Indemnifying Party isconducting the defense of such claim as provided in this Section 6.4, the Indemnified Party may retain separate co-counsel at its expense and may participatein the defense of such claim, and neither the Indemnified Party nor the Indemnifying Party shall consent to the entry of any Judgment or enter into anysettlement with respect to such claim without the prior written consent of the other unless such Judgment or settlement (a) provides for the payment by theIndemnifying Party of money as sole relief (if any) for the claimant (other than customary and reasonable confidentiality obligations relating to such claim,Judgment or settlement), (b) results in the full and general release of the Indemnified Party from all liabilities arising out of, relating to or in connection withsuch claim and (c) does not involve a finding or admission of any violation of any law, rule, regulation or Judgment, or the rights of any Person, and has noeffect on any other claims that may be made against the Indemnified Party. In the event the Indemnifying Party does not or ceases to conduct the defense ofsuch claim as so provided, (i) the Indemnified Party may defend against, and consent to the entry of any Judgment or enter into any settlement with respect to,such claim in any manner it may reasonably deem to be appropriate, (ii) subject to the limitations set forth in Section 6.3, the Indemnifying Party shallreimburse the Indemnified Party promptly and periodically for the reasonable out-of-pocket costs of defending against such claim, including reasonableattorneys’ fees and expenses against reasonably detailed invoices, and (iii) the Indemnifying Party shall remain responsible for any Losses the IndemnifiedParty may suffer as a result of such claim to the full extent provided in this Article 6.Section 6.5 Exclusive Remedy. Except as set forth in Section 9.13, from and after Closing, the rights of the parties hereto pursuant to (andsubject to the conditions of) this Article 6 shall be the sole and exclusive remedy of the parties hereto and their respective Affiliates with respect to anyclaims (whether based in contract, tort or otherwise) resulting from or relating to any breach of the representations, warranties covenants and agreements madeunder this Agreement or any certificate, document or instrument delivered hereunder, and each party hereto hereby waives, to the fullest extent permittedunder applicable law, and agrees not to assert after Closing, any other claim or action in respect of any such breach. Notwithstanding the foregoing, claims forcommon law fraud shall not be waived or limited in any way by this Article 6. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.21ARTICLE 7TERMINATIONSection 7.1 Grounds for Termination. This Agreement may be terminated at any time prior to the Closing:(a) by mutual written agreement of the Buyer and the Seller; or(b) by the Buyer upon notice in writing to the Seller at any time after March 31, 2017, if by such date the Closing shall not have beenconsummated for any reason other than a material breach by the Buyer of any of its representations, warranties, covenants, agreements or obligations underthis Agreement.Section 7.2 Automatic Termination. Unless earlier terminated as provided in Section 7.1, this Agreement shall continue in full force and effectuntil 60 days after such time as Licensee (or any other applicable Third Party) is no longer obligated to make any payments of the Royalty, at which pointthis Agreement shall automatically terminate, except with respect to any rights that shall have accrued prior to such termination.Section 7.3 Survival. Notwithstanding anything to the contrary in this Article 7, the following provisions shall survive termination of thisAgreement: Section 1.4 (True Sale), Section 5.1 (Disclosures), Article 6 (Indemnification), Article 8 (Confidentiality) and Article 9 (Miscellaneous).Termination of the Agreement shall not relieve any party of liability in respect of breaches under this Agreement by any party on or prior to termination.ARTICLE 8CONFIDENTIALITYSection 8.1 Confidentiality. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing by the parties, the partieshereto agree that, for the term of the License Agreement and for [ * ] thereafter, each party (the “Receiving Party”) shall keep confidential and shall notpublish or otherwise disclose and shall not use for any purpose other than as provided for in this Agreement (which includes the exercise of any rights or theperformance of any obligations hereunder) any information furnished to it by or on behalf of the other party (the “Disclosing Party”) pursuant to thisAgreement (including any and all information provided by Amgen pursuant to the Amgen Agreement) or the Non-Disclosure Agreement effectiveDecember 19, 2014, as amended, between RP Management, LLC, on behalf of the Buyer, and the Seller under which the terms of the transaction and thisAgreement were negotiated (the “Confidentiality Agreement”) (such information, “Confidential Information” of the Disclosing Party) except for that portionof such information that:(a) was already known to the Receiving Party, other than under an obligation of confidentiality, at the time of disclosure by the Disclosing Party;(b) was generally available to the public or otherwise part of the public domain at the time of its disclosure to the Receiving Party; [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.22(c) became generally available to the public or otherwise part of the public domain after its disclosure and other than through any act or omissionof the Receiving Party or its Representatives in breach of this Agreement;(d) is independently developed by the Receiving Party or any of its Affiliates without the use of the Confidential Information;(e) was disclosed to the Receiving Party other than under an obligation of confidentiality, by a Third Party who had no obligation to theDisclosing Party not to disclose such information to others; or(f) is subsequently disclosed to the Receiving Party on a non-confidential basis by a Third Party without obligations of confidentiality withrespect thereto.Section 8.2 Authorized Disclosure. Either party may disclose Confidential Information to the extent such disclosure is reasonably necessary inthe following situations:(a) prosecuting or defending litigation;(b) complying with applicable laws and regulations, including regulations promulgated by a global stock market or securities exchanges;(c) complying with a valid order of a court of competent jurisdiction or other Governmental Entity;(d) for regulatory, tax or customs purposes;(e) for audit purposes, provided that each recipient of Confidential Information must be bound by customary obligations of confidentiality andnon-use prior to any such disclosure;(f) disclosure to its Affiliates and Representatives on a need to know basis, provided that each recipient of Confidential Information must bebound by customary obligations of confidentiality and non-use prior to any such disclosure;(g) upon the prior written consent of the Disclosing Party; or(h) disclosure to potential licensees, investors and other sources of funding, including debt financing or co-investors, and their respectiveaccountants, financial advisors and other professional representatives, provided, that such disclosure shall be made only to the extent customarily required toconsummate such investment or financing transaction and that each recipient of Confidential Information must be bound by customary obligations ofconfidentiality and non-use prior to any such disclosure;provided that in the event the Receiving Party is required to make a disclosure of the Disclosing Party’s Confidential Information pursuant to Section 8.2(a),(b), (c) or (d)), it will, except where impracticable, give reasonable advance written notice to the Disclosing Party of such disclosure and use [ * ] to secureconfidential treatment of such information. For clarity, any use or [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.23disclosure of Confidential Information disclosed under the Confidentiality Agreement that is authorized under this Article 8 shall not be restricted by, or bedeemed a violation of, the Confidentiality Agreement. In any event, the Buyer shall not file or assist any Third Party in filing any patent application basedupon or using the Confidential Information of Seller provided hereunder.Notwithstanding anything set forth in this Agreement, including Section 8.2, patent and patent-related material and documentation may be only disclosed toor accessed by Buyer’s counsel, without further disclosure to Buyer or its Representatives.ARTICLE 9MISCELLANEOUSSection 9.1 Definitions. As used in this Agreement, the following terms shall have the following meanings:“Affiliate” means, with respect to any particular Person, any other Person directly or indirectly controlling, controlled by or under common controlwith such particular Person.“Agreement” is defined in the preamble.“[ * ]” is defined in Section 5.13.“[ * ]” is defined in Section 5.13.“Amendment No. 2” is defined in the definition of License Agreement.“Amendment No. 5” is defined in the definition of License Agreement.“Amendment No. 6” is defined in the definition of License Agreement.“Annual Update Meeting” is defined in Section 5.4(b).“Bankruptcy Laws” means, collectively, bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, fraudulent transfer or othersimilar laws affecting the enforcement of creditors’ rights generally.“Bill of Sale” is defined in Section 2.4.“Business Day” means any day other than (i) a Saturday or Sunday or (ii) a day on which banking institutions located in New York are permitted orrequired by applicable law or regulation to remain closed.“Buyer” is defined in the preamble.“Buyer Representatives” shall mean the up to three (3) individuals Buyer designates to attend the Annual Update Meetings and the Quarterly UpdateMeetings. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.24“Buyer Indemnified Parties” is defined in Section 6.1(a).“[ * ]” has the meaning assigned such term in Section 1.7 of the License Agreement.“CK-452” has the meaning assigned such term in Section 1.9 of the License Agreement, currently known as omecamtiv mecarbil that is the subject ofdevelopment under the License Agreement.“CK Intellectual Property” has the meaning assigned such term in Section 1.10 of the License Agreement, as supplemented by the meaning assignedsuch term in Amendment No. 2.“CK Product Opportunity” has the meaning assigned such term in Section 4.6.1.3 of the License Agreement.“Closing” means the closing of the sale, transfer, assignment and conveyance of the Purchased Royalty hereunder.“Closing Date” means the date on which the Closing occurs.“Co-Invest Option” has the meaning assigned such term in Section 1.6 of the License Agreement.“Commercialization” means [ * ], and shall include [ * ]. When used as a verb, “Commercialize” shall mean to engage in Commercialization.“Compound” means a Compound within the meaning of Section 1.21 of the License Agreement that, [ * ] (a) [ * ]; or (b) [ * ].“Delivered by the Seller” shall mean such documentation as is attached to the certificate(s) delivered at the Closing pursuant to Section 2.3(a) and iscertified true, correct and complete by the Secretary or Assistant Secretary of the Seller pursuant to such certificates.“Development” shall mean [ * ].“Disclosure Schedule” means the Disclosure Schedule, dated as of the date hereof, delivered to the Buyer or Buyer’s counsel by the Seller concurrentlywith the execution of this Agreement.“Existing In-Development Patents” is defined in Section 3.1(j)(i)“Existing Sublicense” is defined in Section 3.1(h)(ix).“Governmental Entity” means any: (i) nation, principality, republic, state, commonwealth, province, territory, county, municipality, district or otherjurisdiction of any nature; (ii) federal, state, local, municipal, foreign or other government; (iii) governmental or quasi-governmental authority of any nature(including any governmental division, subdivision, department, agency, bureau, branch, office, commission, council, board, instrumentality, officer, official,representative, organization, unit, body or other entity and any court, arbitrator or other tribunal); (iv) multi-national organization or body; or (v) individual,body or other entity exercising, or entitled to exercise, any executive, legislative, judicial, administrative, regulatory, police, military or taxing authority orpower of any nature. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.25“Indemnified Party” is defined in Section 6.2.“Indemnifying Party” is defined in Section 6.2.“Initiation” has the meaning set forth in Section 1.40 of the License Agreement.“Intellectual Property” shall mean the collectively the CK Intellectual Property and Joint Patent Rights with respect to Compounds.“Joint Patent Rights” has the meaning assigned such term in Section 1.43 of the License Agreement, including any Research Patent Rights deemedincluded in Joint Patent Rights pursuant to Amendment No. 5 with respect to Compounds.“Judgment” means any judgment, order, writ, injunction, citation, award or decree of any nature.“Knowledge of the Seller” means actual knowledge after due inquiry.“Lender” is defined in the definition of Loan Agreement.“Letter Agreement” is defined in the definition of License Agreement.“License Agreement” means that certain Collaboration and Option Agreement by and between Licensee and the Seller dated December 29, 2006, asamended by that certain Amendment No. 1 to Collaboration and Option Agreement dated June 23, 2008, as amended by that certain Amendment Number 2to Collaboration and Option Agreement dated September 30, 2008 (“Amendment No. 2”), as amended by that certain Amendment Number 3 to Collaborationand Option Agreement dated October 31, 2008, as amended by that certain Amendment No. 4 to Collaboration and Option Agreement dated February 20,2009, as amended by that certain Amendment No. 5 to Collaboration and Option Agreement dated November 1, 2010 (“Amendment No. 5”), as amended bythat certain Amendment No. 6 to Collaboration and Option Agreement dated June 11, 2013 (“Amendment No. 6”), as amended by that certain AmendmentNo. 7 to Collaboration and Option Agreement dated March 19, 2015, as amended by that certain Letter of Agreement dated August 29, 2016, by and amongLicensee, the Seller, Les Laboratoires Servier and Institut de Recherches Internationales Servier (“Letter Agreement”), as amended by that certain AmendmentNo. 8 to Collaboration and Option Agreement dated November 30, 2016, as amended by the letter dated January 27, 2012 modifying the Compound Criteria,and as amended by the Licensee Consent.“Licensed Patents” means the Patent Rights (including any provisionals, divisionals, continuations, continuations-in-part, inventor’s certificates,reissues, reexaminations, extensions or other governmental actions which extend any of the subject matter of a Patent Right, and any substitutions,confirmations, registrations or additions of or to any of the foregoing) licensed, in whole or in part, to Licensee under the License Agreement with respect toCompounds. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.26“Licensee” means Amgen Inc., a Delaware corporation.“Licensee Consent” is defined in Section 2.7.“Licensee Patents” has the meaning assigned to the term “Amgen Patent Rights” in Section 1.5 of the License Agreement, as supplemented by the term“Amgen Intellectual Property” in Amendment No. 2.“Licensee Option” has the meaning assigned to the term “Amgen Option” in Section 1.4 of the License Agreement.“Licensee Security Agreement” means the Security Agreement dated December 29, 2006.“Lien” means any mortgage, lien, pledge, charge, adverse claim, security interest, encumbrance or restriction of any kind, including any restriction onuse, transfer or exercise of any other attribute of ownership of any kind.“Loan Agreement” means that certain Loan and Security Agreement, dated as of October 19, 2015, by and among Oxford Finance, LLC, as collateralagent and as lender thereunder, Silicon Valley Bank, as lender thereunder, the other lenders party thereto from time to time (collectively and individually,“Lender”) and the Seller.“Loss” means any and all Judgments, damages, losses, claims, costs, liabilities and expenses, including reasonable fees and out-of-pocket expenses ofcounsel; provided, however, that “Loss” shall not include any consequential, punitive, special or incidental damages.“Marketing Approval” means the approval of a new drug application (as such term is used under the Federal Food, Drug, and Cosmetic Act) or otherapplicable pharmaceutical approval submission to the U.S. Food and Drug Administration, or any successor agency thereto, for marketing approval suchagency necessary for the Commercialization of a pharmaceutical product in the United States.“Material Adverse Effect” means (A) any event, occurrence, fact, condition or change that, individually or in the aggregate, adversely affects in anymaterial respect any one or more of the following: (i) the Purchased Royalty (including the timing, amount, or duration thereof) or any payment due to Buyerhereunder set forth in this Agreement; (ii) CK-452 or any Compound then being developed or Commercialized; (iii) the ability of the Seller to perform itsobligations under this Agreement; (iv) the validity or enforceability of this Agreement or the rights and remedies of the Buyer hereunder; (v) the legal andcontractual obligations of the Seller under, or the legal obligations of the Licensee to pay the Purchased Royalty to the Buyer pursuant to, the terms of thisAgreement; or (vi) the ability of the Seller to perform any of its obligations under the License Agreement with respect to CK-452 or any Compounds; or (B) [* ].“Modification” is defined in Section 5.6.“Net Sales” shall have the meaning assigned such term in Section 1.48 of the License Agreement. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.27“Patent Right” has the meaning assigned such term in Section 1.50 of the License Agreement.“Permitted Liens” means any (i) mechanic’s, materialmen’s, and similar liens for amounts not yet due and payable or (ii) statutory liens for taxes not yetdue and payable or for taxes that the taxpayer is contesting in good faith.“Person” means any individual, firm, corporation, company, partnership, limited liability company, trust, joint venture, association, estate, trust,Governmental Entity or other entity, enterprise, association or organization.“Phase III Trial” shall have the meaning assigned such term in Section 1.51.4 of the License Agreement.“Press Release” means a joint press release describing this Agreement and the transactions contemplated by this Agreement that is mutually agreed byBuyer and Seller.“Pro-Rata Share” means [ * ].“Proceeds” means any amounts actually recovered by the Seller as a result of any settlement or resolution of any actions, suits, proceedings, claims ordisputes related to the License Agreement with respect to the Compounds.“Program” means the program to research, develop, manufacture, and Commercialize the Compounds for the treatment of heart failure.“Purchase Price” is defined in Section 1.2.“Purchased Royalty” means the right to receive the percentage of the Net Sales of all Compounds, including CK-452 (omecamtiv mecarbil), during theRoyalty Term in each country in the Territory through and including December 31, 2035 at the applicable royalty rate set forth in the table below: If Marketing Approval for CK-452 (omecamtiv mecarbil) is received Royalty Rate (1)(2)Prior to [ * ] 4.5%After [ * ] [ * ]%After [ * ] [ * ]%After [ * ] [ * ]%After [ * ] [ * ]%After [ * ] 5.5%(1)If one or more marketing approvals are received outside the U.S. for the first Compound prior to receipt of Marketing Approval for the first Compound,then the Royalty Rate applicable prior to receipt of the Marketing Approval shall be the Royalty Rate in the table escalating [ * ] until MarketingApproval is obtained. (2)[ * ]. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.28together with a portion of any payments to the Seller under the License Agreement made in lieu of Royalties under the License Agreement, which portion isdetermined on the basis of the financial equivalent of the applicable Royalty Rate multiplied by the Net Sales with respect to which such “in lieu of”payments were made, and any overdue interest on such Royalties payable to Seller by Licensee pursuant to Section 13.16 of the License Agreement. To theextent that payments are made to the Seller under the License Agreement in lieu of Royalties, the parties shall discuss in good faith the meaning of “financialequivalent” herein.“Quarterly Update Meeting” is defined in Section 5.4(b).“Representative” means, with respect to any Person, (i) any direct or indirect stockholder, member or partner of such Person and (ii) any manager,director, officer, employee, agent, advisor or other representative (including attorneys, accountants, consultants, bankers, financial advisors and actual andpotential lenders and investors) of such Person.“Research Patent Rights” shall have the meaning assigned such term in Amendment No. 5 with respect to Compounds.“Royalty” means all payments payable by Licensee to the Seller pursuant to Section 13.4 of the License Agreement (including payments pursuant toSection 2(c)(ii) of Amendment No. 6) with respect to all Compounds in the Territory from and after the Closing Date and any payments to the Seller under theLicense Agreement in lieu of such payments with respect to all Compounds, and any overdue interest on such royalty amounts payable to the Seller pursuantto Section 13.16 of the License Agreement. The Purchased Royalty is a portion of the Royalty.“Royalty Reduction” is defined in Section 3.1(h)(xi).“Royalty Reports” means the quarterly reports deliverable by Licensee pursuant to Section 13.4.6 of the License Agreement.“Royalty Term” shall have the meaning assigned such term in Section 1.60 of the License Agreement.“Seller” is defined in the preamble.“Seller Indemnified Parties” is defined in Section 6.1(b).“Seller Representative” means one member from the Seller’s representatives then serving on one of the Joint Steering Committee, JointCommercialization Committee or Joint Development Committee (as each such term is defined in the License Agreement) designated by the Buyer to attendthe Annual Update Meetings and the Quarterly Update Meetings.“Subject Transaction” has the meaning assigned such term in Section 2.9 of the License Agreement.“Sublicensee” is defined in Section 3.1(h)(ix). [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.29“Term Loan Facility” means that certain term loan facility for up to $40,000,000 principal amount pursuant to the Loan Agreement.“Territory” means the entire world.“Third Party” has the meaning assigned such term in Section 1.64 of the License Agreement.“Transfer” means any sale, transfer, hypothecation, assignment, any manner of conveyance or the granting of a Lien (other than a Permitted Lien).“UCC” means Article 9 of the Uniform Commercial Code of the State of Delaware, as in effect from time to time.Section 9.2 Certain Interpretations. Except where expressly stated otherwise in this Agreement, the following rules of interpretation apply to thisAgreement:(a) “either” and “or” are not exclusive and “include,” “includes” and “including” are not limiting and shall be deemed to be followed by thewords “without limitation;”(b) “extent” in the phrase “to the extent” means the degree to which a subject or other thing extends, and such phrase does not mean simply “if;”(c) “hereof,” “hereto,” “herein” and “hereunder” and words of similar import when used in this Agreement refer to this Agreement as a whole andnot to any particular provision of this Agreement;(d) references to a Person are also to its permitted successors and assigns;(e) definitions are applicable to the singular as well as the plural forms of such terms;(f) unless otherwise indicated, references to an “Article”, “Section” or “Exhibit” refer to an Article or Section of, or an Exhibit to, this Agreement,and references to a “Schedule” refer to the corresponding part of the Disclosure Schedule;(g) references to “$” or otherwise to dollar amounts refer to the lawful currency of the United States;(h) references to an agreement or other document include references to any annexes, exhibits and schedules attached thereto excluding anyamendments, restatements, reformations, supplements or other modifications after the date hereof;(i) references to a law include any amendment or modification to such law and any rules and regulations issued thereunder, whether suchamendment or modification is made, or issuance of such rules and regulations occurs, before or after the date of this Agreement; and [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.30(j) references to Sections and Articles in the License Agreement that include the term “Compound” or “Compounds” shall be deemed to meanCompound (or Compounds) as defined in this Agreement.Section 9.3 Headings. The table of contents and the descriptive headings of the several Articles and Sections of this Agreement and the Exhibitsand Schedules are for convenience only, do not constitute a part of this Agreement and shall not control or affect, in any way, the meaning or interpretation ofthis Agreement.Section 9.4 Notices. All notices and other communications under this Agreement shall be in writing and shall be by email with PDF attachment,facsimile, courier service or personal delivery to the following addresses, or to such other addresses as shall be designated from time to time by a party heretoin accordance with this Section 9.4:If to the Seller, to it at:Cytokinetics, Incorporated280 East Grand AvenueSouth San Francisco, CA 94080Attn: General CounselTelephone: (650) 624-2925Facsimile: (650) 624-3010Email: cmcdowell@cytokinetics.comwith another copy to:Cooley LLP3175 Hanover St.Palo Alto, CA 94304Attention: Glen SatoTelephone: (650) 843-5502Facsimile: (650) 849-7400Email: gsato@cooley.comIf to the Buyer, to it at:RPI Finance Trustc/o RP Management, LLC110 East 59th St, 33rd FloorNew York, NY 10022Attention: George LloydTelephone: (212) 883-2280E-mail: glloyd@royaltypharma.comFacsimile: (212) 883-2260 [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.31with a copy to:Goodwin Procter LLP100 Northern AvenueBoston, Massachusetts 02210Attention: Arthur McGivernTelephone: 617-570-1971Facsimile: (617) 523-1231Email: AMcGivern@goodwinlaw.comAll notices and communications under this Agreement shall be deemed to have been duly given (i) when delivered by hand, if personally delivered, (ii) whenreceived by a recipient, if sent by email, (iii) when sent, if sent by facsimile, with an acknowledgement of sending being produced by the sending facsimilemachine or (iv) one Business Day following sending within the United States by overnight delivery via commercial one-day overnight courier service.Section 9.5 Expenses. Except as otherwise provided herein, all fees, costs and expenses (including any legal, accounting and banking fees)incurred in connection with the preparation, negotiation, execution and delivery of this Agreement and to consummate the transactions contemplated herebyshall be paid by the party hereto incurring such fees, costs and expenses.Section 9.6 Assignment. The Seller shall not sell, assign or otherwise transfer all or any portion of its interest in the Licensed Patents, the LicenseAgreement or this Agreement to any Third Party or the Licensee by operation of law, merger, change of control, or otherwise, unless in connection therewith(a) such Person acquires all of the Sellers’ interest in all of the Licensed Patents, the License Agreement and this Agreement and (b) prior to closing any suchtransaction, the Seller causes such Person to deliver a writing to the Buyer in which (i) if such Person is not the Licensee, such Person assumes all of theobligations of the Seller to the Buyer under this Agreement, and (ii) if such Person is the Licensee, the Licensee assumes all of the obligations of the Seller tothe Buyer hereunder and agrees to pay the Purchased Royalty directly to the Buyer notwithstanding any subsequent termination of the License Agreement bythe Licensee. The preceding sentence shall not prohibit, restrict or limit Seller from entering into an additional Royalty monetization transaction; providedthat such additional Royalty monetization does not conflict with the other terms and conditions of this Agreement or the License Agreement. Subject to thefirst sentence of this Section 9.6, this Agreement shall be binding upon, inure to the benefit of and be enforceable by, the parties hereto and their respectivepermitted successors and assigns. The Buyer may assign this Agreement, provided that the Buyer promptly thereafter notifies the Seller and any such assigneepromptly thereafter agrees in writing to be bound by this Agreement and the applicable terms of the License Agreement (including the consent to enter intothis Agreement), and in any event such assignment shall be of the Agreement in its entirety. Any purported assignment in violation of this Section 9.6 shallbe null and void.Section 9.7 Amendment and Waiver.(a) This Agreement may be amended, modified or supplemented only in a writing signed by each of the parties hereto. Any provision of thisAgreement may be waived only in a writing signed by the party hereto granting such waiver. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.32(b) No failure or delay on the part of any party hereto in exercising any right, power or remedy hereunder shall operate as a waiver thereof, norshall any single or partial exercise of any such right, power or remedy preclude any other or further exercise thereof or the exercise of any other right, power orremedy. No course of dealing between the parties hereto shall be effective to amend, modify, supplement or waive any provision of this Agreement.Section 9.8 Entire Agreement. This Agreement, the Exhibits annexed hereto and the Disclosure Schedule constitute the entire understandingbetween the parties hereto with respect to the subject matter hereof and supersede all other understandings and negotiations with respect thereto. As of thedate hereof, the Confidentiality Agreement is hereby terminated without further force and effect, superseded by Article 8 of this Agreement and allconfidential information disclosed pursuant to such agreement shall be deemed Confidential Information of the applicable party hereunder, and allobligations between the parties relating to confidentiality shall be governed by Article 8 of this Agreement.Section 9.9 No Third Party Beneficiaries. This Agreement is for the sole benefit of the Seller and the Buyer and their permitted successors andassigns and nothing herein expressed or implied shall give or be construed to give to any Person, other than the parties hereto and such successors andassigns, any legal or equitable rights hereunder.Section 9.10 Governing Law. This Agreement shall be governed by, and construed in accordance with, the laws of the State of New York withoutgiving effect to any choice or conflict of law provision or rule that would cause the application of the laws of any other jurisdiction.Section 9.11 JURISDICTION; VENUE.(a) EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY AND UNCONDITIONALLY SUBMITS, FOR ITSELF AND ITS RESPECTIVEPROPERTY AND ASSETS, TO THE EXCLUSIVE JURISDICTION OF ANY NEW YORK STATE COURT OR FEDERAL COURT OF THE UNITED STATESOF AMERICA SITTING IN NEW YORK COUNTY, NEW YORK, AND ANY APPELLATE COURT THEREOF, IN ANY ACTION OR PROCEEDINGARISING OUT OF OR RELATING TO THIS AGREEMENT, OR FOR RECOGNITION OR ENFORCEMENT OF ANY JUDGMENT IN RESPECT THEREOF,AND THE BUYER AND THE SELLER HEREBY IRREVOCABLY AND UNCONDITIONALLY AGREE THAT ALL CLAIMS IN RESPECT OF ANY SUCHACTION OR PROCEEDING MAY BE HEARD AND DETERMINED IN ANY SUCH NEW YORK STATE COURT OR, TO THE FULLEST EXTENTPERMITTED BY APPLICABLE LAW, IN SUCH FEDERAL COURT. THE BUYER AND THE SELLER HEREBY AGREE THAT A FINAL JUDGMENT INANY SUCH ACTION OR PROCEEDING SHALL BE CONCLUSIVE AND MAY BE ENFORCED IN OTHER JURISDICTIONS BY SUIT ON THEJUDGMENT OR IN ANY OTHER MANNER PROVIDED BY APPLICABLE LAW. EACH OF THE BUYER AND THE SELLER HEREBY SUBMITS TO THEEXCLUSIVE PERSONAL JURISDICTION AND VENUE OF SUCH NEW YORK STATE AND FEDERAL COURTS. THE BUYER AND THE SELLERAGREE, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, THAT PROCESS MAY BE SERVED ON THE BUYER OR THE SELLER INTHE SAME MANNER THAT NOTICES MAY BE GIVEN PURSUANT TO SECTION 9.4 HEREOF. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.33(b) EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES, TO THE FULLEST EXTENT IT MAYLEGALLY AND EFFECTIVELY DO SO, ANY OBJECTION THAT IT MAY NOW OR HEREAFTER HAVE TO THE LAYING OF VENUE OF ANY ACTIONOR PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT IN ANY NEW YORK STATE OR FEDERAL COURT. EACH OF THE BUYERAND THE SELLER HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, THE DEFENSE OF ANINCONVENIENT FORUM TO THE MAINTENANCE OF SUCH ACTION OR PROCEEDING IN ANY SUCH COURT.Section 9.12 Severability. If any term or provision of this Agreement shall for any reason be held to be invalid, illegal or unenforceable in anysituation in any jurisdiction, then, to the extent that the economic and legal substance of the transactions contemplated hereby is not affected in a mannerthat is materially adverse to either party hereto, all other terms and provisions of this Agreement shall nevertheless remain in full force and effect and theenforceability and validity of the offending term or provision shall not be affected in any other situation or jurisdiction.Section 9.13 Specific Performance. Each of the parties acknowledges and agrees that the other party may be damaged irreparably in the eventany of the provisions of this Agreement are not performed in accordance with their specific terms or otherwise are breached or violated. Accordingly, each ofthe parties agrees that, without posting bond or other undertaking, the other party will be entitled to seek an injunction or injunctions to prevent breaches orviolations of the provisions of this Agreement and to enforce specifically this Agreement and the terms and provisions hereof in any action, suit or otherproceeding instituted in any court of the United States or any state thereof having jurisdiction over the parties and the matter in addition to any other remedyto which it may be entitled, at law or in equity.Section 9.14 Trustee Capacity of Wilmington Trust Company. Notwithstanding anything contained herein to the contrary, it is expresslyunderstood and agreed by the parties hereto that (i) this Agreement is executed and delivered by Wilmington Trust Company, not individually or personallybut solely in its trustee capacity, in the exercise of the powers and authority conferred and vested in it under the trust deed of the Buyer, (ii) each of therepresentations, undertakings and agreements herein made on the part of the Buyer is made and intended not as a personal representation, undertaking andagreement by Wilmington Trust Company but is made and intended for the purpose of binding only the Buyer and (iii) under no circumstances shallWilmington Trust Company be personally liable for the payment of any indebtedness or expenses of the Buyer or be liable for the breach or failure of anyobligation, representation, warranty or covenant made or undertaken by the Buyer under this Agreement or any related documents. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.34Section 9.15 Relationship of Parties. The relationship between the Buyer and the Seller is solely that of purchaser and seller, and neither theBuyer nor the Seller has any fiduciary or other special relationship with the other party or any of its Affiliates. This Agreement is not a partnership or similaragreement, and nothing contained herein shall be deemed to constitute the Buyer and the Seller as a partnership, an association, a joint venture or any otherkind of entity or legal form for any purposes, including any Tax purposes. The Buyer and the Seller agree that they shall not take any inconsistent positionwith respect to such treatment in a filing with any Governmental Entity.Section 9.16 Counterparts. This Agreement may be executed in any number of counterparts and by the parties hereto in separate counterparts,each of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. Copies ofexecuted counterparts transmitted by telecopy, facsimile or other similar means of electronic transmission, including “PDF,” shall be considered originalexecuted counterparts, provided receipt of such counterparts is confirmed.[Signature Page Follows] [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.35IN WITNESS WHEREOF, the parties hereto have caused this Royalty Purchase Agreement to be executed and delivered by their respectiverepresentatives thereunto duly authorized as of the date first above written. CYTOKINETICS, INCORPORATEDBy: /s/ Robert I. Blum Name: Robert I. Blum Title: President & CEORPI FINANCE TRUSTBy: Wilmington Trust Company, not in its individualcapacity but solely in its capacity as owner trusteeBy: /s/ Beverly D. Capers Name: Beverly D. Capers Title: Assistant Vice President[SIGNATURE PAGE TO THE ROYALTY PURCHASE AGREEMENT]Exhibit A: Stock Purchase Agreement [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.Exhibit BFORM OF BILL OF SALEThis BILL OF SALE is dated as of February 1, 2017 (the “Closing Date”) by Cytokinetics Incorporated, a Delaware corporation (the “Seller”), in favorof RPI Finance Trust, a Delaware statutory trust (the “Buyer”).RECITALSWHEREAS, the Seller and the Buyer are parties to that certain Royalty Purchase Agreement, dated as of the Closing Date (the “Agreement”), pursuantto which, among other things, the Seller agrees to sell, assign, transfer, convey and grant to the Buyer, and the Buyer agrees to purchase, acquire and acceptfrom the Seller, all of the Seller’s right, title and interest in, to and under the Purchased Royalty, for the consideration described in the Agreement; andWHEREAS, the parties hereto now desire to carry out the purposes of the Agreement by the execution and delivery of this instrument evidencing theBuyer’s purchase, acquisition and acceptance of the Purchased Royalty;NOW, THEREFORE, in consideration of the premises and the mutual agreements set forth in the Agreement and of other good and valuableconsideration, the receipt and adequacy of which are hereby acknowledged, the parties hereto agree as follows: 1.The Seller, by this Bill of Sale, does hereby sell, assign, transfer, convey and grant to the Buyer, and the Buyer does hereby purchase, acquire andaccept, the Purchased Royalty. 2.The parties hereto acknowledge that the Buyer is not assuming any of the liabilities or obligations of Seller. 3.This Bill of Sale (i) is made pursuant to, and is subject to the terms of, the Agreement, nothing herein shall be deemed to modify, expand or limitin any way the terms of the Agreement including any of the representations, warranties, covenants and obligations of the parties thereunder and(ii) shall be binding upon and inure to the benefit of the Seller, the Buyer and their respective successors and permitted assigns, for the uses andpurposes set forth and referred to above, effective immediately upon its delivery to the Buyer. 4.In the event of any conflict or inconsistency between the terms, provisions and conditions of this Bill of Sale and the Agreement, the terms,provisions and conditions of the Agreement shall control. 5.THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORKWITHOUT GIVING EFFECT TO ANY CHOICE OR CONFLICT OF LAW PROVISION OR RULE THAT WOULD CAUSE THE APPLICATIONOF THE LAWS OF ANY OTHER JURISDICTION. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED. 6.This Bill of Sale may be executed in any number of counterparts, each of which so executed shall be deemed to be an original, but all of suchcounterparts shall together constitute but one and the same instrument. 7.Notwithstanding anything contained herein to the contrary, it is expressly understood and agreed by the parties hereto that (i) this Bill of Sale isexecuted and delivered by Wilmington Trust Company, not individually or personally but solely in its trustee capacity, in the exercise of thepowers and authority conferred and vested in it under the trust deed of the Buyer, (ii) each of the representations, undertakings and agreementsherein made on the part of the Buyer is made and intended not as a personal representation, undertaking and agreement by Wilmington TrustCompany but is made and intended for the purpose of binding only the Buyer and (iii) under no circumstances shall Wilmington Trust Companybe personally liable for the payment of any indebtedness or expenses of the Buyer or be liable for the breach or failure of any obligation,representation, warranty or covenant made or undertaken by the Buyer under this Agreement or any related documents. 8.The following terms as used herein shall have the following respective meanings: (a.)“Agreement” is defined in the recitals. (b.)“Bill of Sale” is defined in the preamble. (c.)“Buyer” is defined in the preamble. (d.)“CK-452” has the meaning assigned such term in Section 1.9 of the License Agreement, currently known as omecamtiv mecarbil that isthe subject of development under the License Agreement. (e.)“Closing” means the closing of the sale, transfer, assignment and conveyance of the Purchased Royalty hereunder. (f.)“Closing Date” is defined in the preamble. (g.)“Compound” means a Compound within the meaning of Section 1.21 of the License Agreement that, [ * ]: (a) [ * ]; or (b) [ * ]. (h.)“License Agreement” means that certain Collaboration and Option Agreement by and between Licensee and the Seller datedDecember 29, 2006, as amended by that certain Amendment No. 1 to Collaboration and Option Agreement dated June 23, 2008, asamended by that certain Amendment Number 2 to Collaboration and Option Agreement dated September 30, 2008, as amended by thatcertain Amendment Number 3 to [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED. Collaboration and Option Agreement dated October 31, 2008, as amended by that certain Amendment No. 4 to Collaboration and OptionAgreement dated February 20, 2009, as amended by that certain Amendment No. 5 to Collaboration and Option Agreement datedNovember 1, 2010, as amended by that certain Amendment No. 6 to Collaboration and Option Agreement dated June 11, 2013, asamended by that certain Amendment No. 7 to Collaboration and Option Agreement dated March 19, 2015, as amended by that certainLetter of Agreement dated August 29, 2016, by and among Licensee, the Seller, Les Laboratoires Servier and Institut de RecherchesInternationales Servier, as amended by that certain Amendment No. 8 to Collaboration and Option Agreement dated November 30, 2016,as amended by the letter dated January 27, 2012 modifying the Compound Criteria, and as amended by the Licensee Consent. (i.)“Licensee” means Amgen Inc., a Delaware corporation. (j.)“Licensee Consent” means the duly executed agreement from Licensee in the form Delivered by the Seller to the Buyer at the Closing. (k.)“Marketing Approval” means the approval of a new drug application (as such term is used under the Federal Food, Drug, and CosmeticAct) or other applicable pharmaceutical approval submission to the U.S. Food and Drug Administration, or any successor agency thereto,for marketing approval such agency necessary for the Commercialization of a pharmaceutical product in the United States. (l.)“Net Sales” shall have the meaning assigned such term in Section 1.48 of the License Agreement. (m.)“Purchased Royalty” means the right to receive the percentage of the Net Sales of all Compounds, including CK-452 (omecamtivmecarbil), during the Royalty Term in each country in the Territory through and including December 31, 2035 at the applicable royaltyrate set forth in the table below: If Marketing Approval for CK-452 (omecamtiv mecarbil) is received Royalty Rate (1)(2)Prior to [ * ] 4.5%After [ * ] [ * ]%After [ * ] [ * ]%After [ * ] [ * ]%After [ * ] [ * ]%After [ * ] 5.5% [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.(1) If one or more marketing approvals are received outside the U.S. for the first Compound prior to receipt of Marketing Approval for thefirst Compound, then the Royalty Rate applicable prior to receipt of the Marketing Approval shall be the Royalty Rate in the tableescalating [ * ] until Marketing Approval is obtained.(2) [ * ].together with a portion of any payments to the Seller under the License Agreement made in lieu of Royalties under the LicenseAgreement, which portion is determined on the basis of the financial equivalent of the applicable Royalty Rate multiplied by the NetSales with respect to which such “in lieu of” payments were made, and any overdue interest on such Royalties payable to Seller byLicensee pursuant to Section 13.16 of the License Agreement. To the extent that payments are made to the Seller under the LicenseAgreement in lieu of Royalties, the parties shall discuss in good faith the meaning of “financial equivalent” herein. (n.)“Royalty” means all payments payable by Licensee to the Seller pursuant to Section 13.4 of the License Agreement (including paymentspursuant to Section 2(c)(ii) of Amendment No. 6) with respect to all Compounds in the Territory from and after the Closing Date and anypayments to the Seller under the License Agreement in lieu of such payments with respect to all Compounds, and any overdue interest onsuch royalty amounts payable to the Seller pursuant to Section 13.16 of the License Agreement. The Purchased Royalty is a portion ofthe Royalty. (o.)“Royalty Term” shall have the meaning assigned such term in Section 1.60 of the License Agreement. (p.)“Seller” is defined in the preamble. (q.)“Territory” means the entire world. [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.IN WITNESS WHEREOF, the parties hereto have caused this Bill of Sale to be executed and delivered by their respective representatives thereuntoduly authorized as of the date first above written. CYTOKINETICS, INCORPORATEDBy: /s/ Robert I. Blum Name: Robert I. Blum Title: President & CEORPI FINANCE TRUSTBy: Wilmington Trust Company, not in its individualcapacity but solely in its capacity as owner trusteeBy: /s/ Beverly D. Capers Name: Beverly D. Capers Title: Assistant Vice President [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED ANDFILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED.Exhibit 10.45ConfidentialCYTOKINETICS, INCORPORATEDCOMMON STOCK PURCHASE AGREEMENTTHIS COMMON STOCK PURCHASE AGREEMENT (the “Agreement”) is made as of February 1, 2017 (the “Execution Date”) by and betweenCytokinetics, Incorporated, a Delaware corporation (the “Company”), and RPI Finance Trust, a Delaware statutory trust (the “Investor”).RECITALSWHEREAS, the Company and the Investor have entered into that certain Royalty Purchase Agreement by and between the Company and the Investorof even date herewith (the “Royalty Purchase Agreement”);WHEREAS, pursuant to terms set forth in this Agreement the Company desires to sell to the Investor, and the Investor desires to purchase from theCompany, shares of the Company’s common stock, par value $0.001 per share (the “Common Stock”);NOW, THEREFORE, in consideration of the premises and mutual covenants herein contained, and for other good and valuable consideration, thereceipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows:SECTION 1Purchase and Sale of Shares1.1 Sale of Shares. Subject to the terms and conditions hereof and of the Royalty Purchase Agreement, the Company will issue and sell to the Investor,and the Investor will purchase from the Company, at the Closing (as defined below), 875,656 shares of Common Stock (the “Shares”) for a total purchaseprice of Nine Million Nine Hundred Ninety-Nine Thousand Nine Hundred Ninety-One Dollars and Fifty-Two Cents ($9,999,991.52) (the “AggregatePurchase Price”).1.2 Closing. The purchase and sale of the Shares shall take place at a closing (the “Closing”) to be held at the offices of Cooley LLP, 3175 HanoverStreet, Palo Alto, California 94304-1130, on the Closing Date set forth in the Royalty Purchase Agreement, or such other time as agreed by both parties (the“Closing Date”). At the Closing, the Company will deliver or cause to be delivered to the Investor a certificate or certificates representing the Shares that theInvestor is purchasing and, concurrently, the Investor shall pay the Aggregate Purchase Price by (a) check payable to the Company, (b) wire transfer inaccordance with the Company’s instructions, or (c) any combination of the foregoing. 1Confidential SECTION 2Representations and Warranties of the CompanyExcept as set forth on the Schedule of Exceptions attached hereto as Exhibit A, the Company hereby represents and warrants the following as of theExecution Date:2.1 Organization and Good Standing and Qualifications. The Company is a corporation duly organized, validly existing and in good standing underthe laws of the State of Delaware and has all requisite power and authority to own, lease, operate and occupy its properties and to carry on its business as nowbeing conducted. Except as set forth on the Schedule of Exceptions, the Company does not own more than 50% of the outstanding capital stock of or controlany other business entity. The Company is duly qualified as a foreign corporation to do business and is in good standing in every jurisdiction in which thenature of the business conducted or property owned or leased by it makes such qualification necessary, other than those in which the failure so to qualify orbe in good standing would not have a Material Adverse Effect. For purposes of this Agreement, “Material Adverse Effect” shall mean any event or conditionthat would reasonably be likely to have a material adverse effect on the business, operations, properties or financial condition of the Company and itsconsolidated subsidiaries, taken as a whole, or adversely affect in any material respect the ability of the Company to perform its obligations, or Investor’srights, under the Royalty Purchase Agreement; provided, that none of the following shall constitute a “Material Adverse Effect”: the effects of conditions orevents that are generally applicable to the capital, financial, banking or currency markets and the biotechnology industry, and changes in the market price ofthe Common Stock.2.2 Authorization. (i) The Company has the requisite corporate power and authority to enter into and perform its obligations under this Agreement;(ii) the execution and delivery of this Agreement by the Company, the consummation by the Company of the transactions contemplated hereby and therebyand the issuance, sale and delivery of the Shares have been duly authorized by all necessary corporate action and no further consent or authorization of theCompany or its Board of Directors or stockholders is required; and (iii) the Agreement has been duly executed and delivered and constitutes a valid andbinding obligation of the Company enforceable against the Company in accordance with its terms, except as such enforceability may be limited byapplicable bankruptcy, securities, insolvency, or similar laws relating to, or affecting generally the enforcement of, creditors’ rights and remedies, orindemnification or by other equitable principles of general application.2.3 Valid Issuance of Shares. The issuance of the Shares has been duly authorized by all requisite corporate action. When the Shares are issued, soldand delivered in accordance with the terms of this Agreement for the consideration expressed herein, the Shares will be duly and validly issued andoutstanding, fully paid, and nonassessable, and will be free of all liens and restrictions on transfer other than restrictions on transfer under this Agreement andunder applicable state and federal securities laws and except as set forth in this Agreement the Investor shall be entitled to all rights accorded to a holder ofshares of Common Stock. The Company has reserved a sufficient number of shares of Common Stock for issuance to the Investor in accordance with theCompany’s obligations under this Agreement. 2Confidential 2.4 No Conflict. The execution, delivery and performance of this Agreement, and any other document or instrument contemplated hereby, by theCompany and the consummation by the Company of the transactions contemplated hereby, do not: (i) violate any provision of the Certificate or Bylaws,(ii) conflict with, or constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights oftermination, amendment, acceleration or cancellation of, any material agreement, mortgage, deed of trust, indenture, note, bond, license, lease agreement,instrument or obligation to which the Company is a party where such default or conflict would constitute a Material Adverse Effect, (iii) create or impose alien, charge or encumbrance on any property of the Company under any agreement or any commitment to which the Company is a party or by which theCompany is bound, which would constitute a Material Adverse Effect, (iv) result in a violation of any federal, state, local or foreign statute, rule, regulation,order, writ, judgment or decree (including federal and state securities laws and regulations) applicable to the Company or any of its subsidiaries or by whichany property or asset of the Company are bound or affected where such violation would constitute a Material Adverse Effect, or (v) require any consent of anythird-party that has not been obtained pursuant to any material contract to which the Company is subject or to which any of its assets, operations ormanagement may be subject where the failure to obtain any such consent would constitute a Material Adverse Effect. The Company is not required underfederal, state or local law, rule or regulation to obtain any consent, authorization or order of, or make any filing or registration with, any court orgovernmental agency in order for it to execute, deliver or perform any of its obligations under this Agreement or issue and sell the Shares in accordance withthe terms hereof (other than any filings that may be required to be made by the Company with the Securities and Exchange Commission (the “Commission”),the National Association of Securities Dealers, Inc./Nasdaq or state securities commissions subsequent to the Closing); provided that, for purposes of therepresentation made in this sentence, the Company is assuming and relying upon the accuracy of the relevant representations and agreements of the Investorherein.2.5 Compliance. The Company is not, and the execution and delivery of this Agreement and the consummation of the transactions contemplatedherewith will not cause the Company to be (i) in violation or default of any provision of any instrument, mortgage, deed of trust, loan, contract, commitmentfiled with the Commission Documents (as defined below), (ii) in violation of any provision of any judgment, decree, order or obligation to which it is a partyor by which it or any of its properties or assets are bound, or (iii) in violation of any federal, state or, to its knowledge, local statute, rule or governmentalregulation, in the case of each of clauses (i), (ii) and (iii), which would have a Material Adverse Effect.2.6 Capitalization. As of December 14, 2016 (the “Reference Date”), a total of 40,615,610 shares of Common Stock were issued and outstanding,increased as set forth in the next sentence. Other than in the ordinary course of business, the Company has not issued any capital stock since the ReferenceDate other than pursuant to (i) employee benefit plans disclosed in the Commission Documents, and (ii) outstanding warrants, options or other securitiesdisclosed in the Commission Documents. The outstanding shares of capital stock of the Company have been duly and validly issued and are fully paid andnonassessable, were not issued in violation of any preemptive rights or similar rights to subscribe for or purchase securities, and, for those shares issued untilthe Closing, have been issued in compliance with all federal and state securities laws, in 3Confidential each case except as would not reasonably be expected to have a Material Adverse Effect. Except as set forth in the Commission Documents, there are nooutstanding rights (including, without limitation, preemptive rights), warrants or options to acquire, or instruments convertible into or exchangeable for, anyunissued shares of capital stock or other equity interest in the Company, or any contract, commitment, agreement, understanding or arrangement of any kindto which the Company is a party and relating to the issuance or sale of any capital stock of the Company, any such convertible or exchangeable securities orany such rights, warrants or options. Without limiting the foregoing, no preemptive right, co-sale right, right of first refusal, registration right, or other similarright exists with respect to the Shares or the issuance and sale thereof. There are no shareholder agreements, voting agreements or other similar agreementswith respect to the voting of the Shares to which the Company is a party or, to the knowledge of the Company, between or among any of the Company’sshareholders.2.7 Commission Documents, Financial Statements. The Company’s Common Stock is registered pursuant to Section 12(b) or 12(g) of the SecuritiesExchange Act of 1934, as amended (the “Exchange Act”), and during the past twelve (12) months the Company has timely filed all reports, schedules, forms,statements and other documents required to be filed by it with the Commission pursuant to the reporting requirements of the Exchange Act, includingmaterial filed pursuant to Section 13(a) or 15(d) of the Exchange Act (all of the foregoing, including filings incorporated by reference therein, being referredto herein as the “Commission Documents”). The Company’s Common Stock is currently listed or quoted on the NASDAQ Market. The Company is not inviolation of the listing requirements of the NASDAQ Market and has no knowledge of any facts that would reasonably lead to delisting or suspension of itscommon stock from NASDAQ in the foreseeable future. As of its date, each Commission Document filed within the past twelve (12) months for the year endedDecember 31, 2016 complied in all material respects with the requirements of the Exchange Act and the rules and regulations of the Commissionpromulgated thereunder applicable to such document, and, as of its date, after giving effect to the information disclosed and incorporated by referencetherein, no such Commission Document within the past twelve (12) months contained any untrue statement of a material fact or omit to state a material factrequired to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading.As of their respective dates, the financial statements of the Company included in the Commission Documents filed with the Commission during the pasttwelve months complied as to form and substance in all material respects with applicable accounting requirements and the published rules and regulations ofthe Commission or other applicable rules and regulations with respect thereto. Such financial statements have been prepared in accordance with generallyaccepted accounting principles (“GAAP”) applied on a consistent basis during the periods involved (except (i) as may be otherwise indicated in suchfinancial statements or the notes thereto or (ii) in the case of unaudited interim statements, to the extent they may not include footnotes or may be condensedor summary statements), and fairly present in all material respects the financial position of the Company as of the dates thereof and the results of operationsand cash flows for the periods then ended (subject, in the case of unaudited statements, to normal year-end audit adjustments). 4Confidential 2.8 Internal Controls and Procedures. The Company maintains disclosure controls and procedures as such terms are defined in, and required by, Rule13a-15 and Rule 15d-15 under the Exchange Act. Such disclosure controls and procedures are effective as of the latest date of management’s evaluation ofsuch disclosure controls and procedures as set forth in the Commission Documents to ensure that all material information required to be disclosed by theCompany in the reports that it files or furnishes under the Exchange Act is recorded, processed, summarized and reported within the time periods specified inthe rules and forms of the Commission. The Company maintains a system of internal controls over financial reporting sufficient to provide reasonableassurance that (i) transactions are executed in accordance with management’s general or specific authorizations; and (ii) transactions are recorded asnecessary to permit preparation of financial statements in conformity with GAAP.2.9 Material Adverse Change. Except as disclosed in the Commission Documents, since September 30, 2016, no event or series of events has or haveoccurred that would, individually or in the aggregate, have a Material Adverse Effect on the Company.2.10 No Undisclosed Liabilities. To the Company’s knowledge, neither the Company nor any of its subsidiaries has any liabilities, obligations, claimsor losses (whether liquidated or unliquidated, secured or unsecured, absolute, accrued, contingent or otherwise) that would be required to be disclosed on abalance sheet of the Company or any of its subsidiaries (including the notes thereto) in conformity with GAAP and are not disclosed in the CommissionDocuments, other than those incurred in the ordinary course of the Company’s or its subsidiaries’ respective businesses since September 30, 2016.2.11 No Undisclosed Events or Circumstances. Except for the transactions contemplated by this Agreement and the Royalty Purchase Agreement, noevent or circumstance has occurred or exists with respect to the Company, its subsidiaries, or their respective businesses, properties, operations or financialcondition, which, under applicable law, rule or regulation, requires public disclosure or announcement by the Company but which has not been so publiclyannounced or disclosed and which, individually or in the aggregate, would have a Material Adverse Effect on the Company.2.12 Actions Pending. There is no action, suit, claim, investigation or proceeding pending or, to the knowledge of the Company, threatened against theCompany or any subsidiary which questions the validity of this Agreement or the transactions contemplated hereby or any action taken or to be takenpursuant hereto. Except as set forth in the Commission Documents or as previously disclosed in writing to the Investor, there is no action, suit, claim,investigation or proceeding pending or, to the knowledge of the Company, threatened, against or involving the Company, any subsidiary, or any of theirrespective properties or assets that could be reasonably expected to have a Material Adverse Effect on the Company. Except as set forth in the CommissionDocuments or as previously disclosed in writing to the Investor, no judgment, order, writ, injunction or decree or award has been issued by or, to theknowledge of the Company, requested of any court, arbitrator or governmental agency which could be reasonably expected to result in a Material AdverseEffect. 5Confidential 2.13 Compliance with Law. The businesses of the Company and its subsidiaries have been and are presently being conducted in accordance with allapplicable federal, state and local governmental laws, rules, regulations and ordinances, except as would not reasonably be expected to cause a MaterialAdverse Effect. The Company and each of its subsidiaries have all franchises, permits, licenses, consents and other governmental or regulatory authorizationsand approvals necessary for the conduct of its business as now being conducted by it, except for such franchises, permits, licenses, consents and othergovernmental or regulatory authorizations and approvals, the failure to possess which, individually or in the aggregate, could not reasonably be expected tohave a Material Adverse Effect.2.14 Exemption from Registration, Valid Issuance. Subject to, and in reliance on, the representations, warranties and covenants made herein by theInvestor, the issuance and sale of the Shares in accordance with the terms and on the bases of the representations and warranties set forth in this Agreement,may and shall be properly issued pursuant to Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), Regulation D promulgatedpursuant to the Act (“Regulation D”) and/or any other applicable federal and state securities laws. The sale and issuance of the Shares pursuant to, and theCompany’s performance of its obligations under, this Agreement will not (i) result in the creation or imposition of any liens, charges, claims or otherencumbrances upon the Shares or any of the assets of the Company, or (ii) entitle the holders of any outstanding shares of capital stock of the Company topreemptive or other rights to subscribe to or acquire the Shares or other securities of the Company.2.15 Transfer Taxes. All stock transfer or other taxes (other than income taxes) which are required to be paid in connection with the sale and transfer ofthe Shares to be sold to Investor hereunder will be, or will have been, fully paid or provided for by the Company and all laws imposing such taxes will be orwill have been fully complied with.2.16 Investment Company. The Company is not and, after giving effect to the offering and sale of the Shares, will not be an “investment company” asdefined in the Investment Company Act of 1940, as amended.2.17 Brokers. Except as expressly set forth in this Agreement or the Royalty Purchase Agreement, no brokers, finders or financial advisory fees orcommissions will be payable by the Company or any of its subsidiaries in respect of the transactions contemplated by this Agreement or the RoyaltyPurchase Agreement.SECTION 3Representations and Warranties of the InvestorThe Investor hereby represents and warrants the following as of the date hereof and as of the Closing Date:3.1 Experience. The Investor is experienced in evaluating companies such as the Company, has such knowledge and experience in financial andbusiness matters that the Investor is capable of evaluating the merits and risks of the Investor’s prospective investment in the Company, and has the ability tobear the economic risks of the investment. 6Confidential 3.2 Investment. The Investor is acquiring the Shares for investment for the Investor’s own account and not with the view to, or for resale in connectionwith, any distribution thereof. The Investor understands that the Shares have not been and will not be registered under the Securities Act by reason of aspecific exemption from the registration provisions of the Securities Act which depends upon, among other things, the bona fide nature of the investmentintent as expressed herein. The Investor further represents that it does not have any contract, undertaking, agreement or arrangement with any person to sell,transfer or grant participation to any third person with respect to any of the Shares.3.3 Rule 144. The Investor acknowledges that the Shares must be held indefinitely unless subsequently registered under the Securities Act or anexemption from such registration is available. The Investor is aware of the provisions of Rule 144 promulgated under the Securities Act which permit limitedresale of shares purchased in a private placement subject to the satisfaction of certain conditions. In connection therewith, the Investor acknowledges that theCompany will make a notation on its stock books regarding the restrictions on transfers set forth in this Section 3, subject to Section 7.2, and will transfer theShares on the books of the Company only to the extent not inconsistent herewith and therewith.3.4 Access to Information. The Investor has received and reviewed information about the Company and has had an opportunity to discuss theCompany’s business, management and financial affairs with its management and to review the Company’s facilities. The Investor has had a full opportunityto ask questions of and receive answers from the Company, or any person or persons acting on behalf of the Company, concerning the terms and conditions ofan investment in the Shares. The Investor is not relying upon, and has not relied upon, any statement, representation or warranty made by any person, exceptfor the statements, representations and warranties contained in this Agreement and the Royalty Purchase Agreement.3.5 Authorization. This Agreement when executed and delivered by the Investor will constitute a valid and legally binding obligation of the Investor,enforceable in accordance with its terms, subject to: (i) judicial principles respecting election of remedies or limiting the availability of specific performance,injunctive relief, and other equitable remedies; and (ii) bankruptcy, insolvency, reorganization, moratorium or other similar laws now or hereafter in effectgenerally relating to or affecting creditors’ rights.3.6 Investor Status. The Investor acknowledges that it is either (i) an institutional “accredited investor” as defined in Rule 501(a) of Regulation D ofthe Securities Act (an “Institutional Accredited Investor”) or (ii) a “qualified institutional buyer” as defined in Rule 144A of the Securities Act, as indicatedon Schedule A hereto, and the Investor shall submit to the Company such further assurances of such status as may be reasonably requested by the Company.3.7 No Inducement. The Investor was not induced to participate in the offer and sale of the Shares by the filing of any registration statement inconnection with any public offering of the Company’s securities, and the Investor’s decision to purchase the Shares hereunder was not influenced by theinformation contained in any such registration statement. 7Confidential SECTION 4Conditions to Investor’s Obligations at ClosingThe obligations of the Investor under this Agreement are subject to the fulfillment on or before the Closing of each of the following conditions, any ofwhich may be waived in writing by the Investor (except to the extent not permitted by law):4.1 No Injunction, etc. No preliminary or permanent injunction or other binding order, decree or ruling issued by a court or governmental agency shallbe in effect which shall have the effect of preventing the consummation of the transactions contemplated by this Agreement. No action or claim shall bepending before any court or quasi-judicial or administrative agency of any federal, state, local or foreign jurisdiction or before any arbitrator wherein anunfavorable injunction, judgment, order, decree, ruling or charge would be reasonably likely to (i) prevent consummation of any of the transactionscontemplated by this Agreement, (ii) cause any of the transactions contemplated by this Agreement to be rescinded following consummation or (iii) have theeffect of making illegal the purchase of, or payment for, any of the Shares by the Investor.4.2 Representations and Warranties. The representations and warranties of the Company contained in Section 2 shall have been true and correct in allmaterial respects (except for such representations and warranties that are qualified by “materiality” or “Material Adverse Effect” which shall be true andcorrect in all respects) on and as of the Execution Date with the same effect as though such representations and warranties had been made on and as of suchdate.4.3 Performance. The Company shall have performed and complied with all covenants, agreements, obligations and conditions contained in thisAgreement that are required to be performed or complied with by it on or before the Execution Date.4.4 Compliance Certificate. A duly authorized officer of the Company shall deliver to the Investor at the Closing a certificate stating that theconditions specified in Sections 4.2 and 4.3 have been fulfilled and certifying and attaching the Company’s Certificate of Incorporation, Bylaws andauthorizing Board of Directors resolutions with respect to this Agreement, the Royalty Purchase Agreement and the transactions contemplated hereby andthereby.4.5 Securities Laws. The offer and sale of the Shares to the Investor pursuant to this Agreement shall be exempt from the registration requirements ofthe Securities Act and the registration and/or qualification requirements of all applicable state securities laws.4.6 Authorizations. All authorizations, approvals or permits, if any, of any governmental authority or regulatory body that are required in connectionwith the lawful issuance and sale of the Shares pursuant to this Agreement shall have been duly obtained and shall be effective on and as of the Closing.4.7 Legal Opinion. The Investor shall have received a legal opinion from Cooley LLP in form and substance reasonably acceptable to the Investor. 8Confidential 4.8 Purchase of Royalty. The transactions under the Royalty Purchase Agreement shall have been consummated.SECTION 5Conditions to the Company’s Obligations at ClosingThe obligations of the Company to the Investor under this Agreement are subject to the fulfillment on or before the Closing of each of the followingconditions by the Investor:5.1 Representations and Warranties. The representations and warranties of the Investor contained in Section 3 shall be true and correct in all materialrespects (except for such representations and warranties that are qualified by materiality which shall be true and correct in all respects) on and as of theClosing with the same effect as though such representations and warranties had been made on and as of the Closing.5.2 Securities Law Compliance. The offer and sale of the Shares to the Investor pursuant to this Agreement shall be exempt from the registrationrequirements of the Securities Act and the registration and/or qualification requirements of all applicable state securities laws.5.3 Authorization. All authorizations, approvals or permits, if any, of any governmental authority or regulatory body that are required in connectionwith the lawful issuance and sale of the Shares pursuant to this Agreement shall have been duly obtained and shall be effective on and as of the Closing.5.4 Purchase of Royalty. The transactions under the Royalty Purchase Agreement shall have been consummated.SECTION 6Investor Covenants6.1 Trading Restrictions.(a) Definitions.(i) “Affiliate” shall have the meaning set forth in Rule 12b-2 of the regulations promulgated under the Securities Exchange Act of 1934,as amended.(ii) “Restriction Period” shall mean the period commencing on the Closing Date and continuing until the one year anniversary of theClosing Date. 9Confidential (iii) “Significant Event” shall mean any of the following not involving a violation of this Section 6: (A) the public announcement of aproposal or intention to acquire, or the acquisition, by any person or 13D Group of beneficial ownership of Voting Securities representing 15% or more of thethen outstanding Voting Securities; (B) the public announcement of a proposal or intention to commence, or the commencement, by any person or 13DGroup of a tender or exchange offer to acquire Voting Securities which, if successful, would result in such person or 13D Group owning, when combined withany other Voting Securities owned by such person or 13D Group, 15% or more of the then outstanding Voting Securities; or (C) the entry into by theCompany, or the public announcement by the Company of an intention or determination to enter into, any merger, sale or other business combinationtransaction, or an agreement therefor, pursuant to which the outstanding shares of capital stock of the Company would be converted into cash, otherconsideration or securities of another person or 13D Group or 50% or more of the then outstanding shares of capital stock of the Company would be ownedby persons other than the then current holders of shares of capital stock of the Company, or which would result in all or a substantial portion of theCompany’s assets being sold to any person or 13D Group.(iv) “Voting Securities” shall mean at any time shares of any class of capital stock of the Company which are then entitled to votegenerally in the election of directors.(v) “13D Group” shall mean, with respect to the Voting Securities of the Company, any group of persons formed for the purpose ofacquiring, holding, voting or disposing of such Voting Securities which would be required under Section 13(d) of the Exchange Act and the rules andregulations thereunder to file a statement on Schedule 13D with the Commission as a “person” within the meaning of Section 13(d)(3) of the Exchange Act ifsuch group beneficially owned Voting Securities representing more than 5% of the total combined voting power of all such Voting Securities thenoutstanding.(b) Restriction Period No Sell. The Investor agrees that during the Restriction Period, neither the Investor nor any of its Affiliates shall offer, sell,contract to sell, pledge, grant any option to purchase, make any short sale or otherwise dispose of in any manner, either directly or indirectly (“Sale” or“Sell”), any Shares, or any securities of the Company issued as a dividend or distribution on, or involving a recapitalization or reorganization with respect to,such Shares (collectively, “Covenant Shares”), other than transfers of securities between and among the Company and any one or more of its Affiliates.Without limiting the Company’s obligations under Section 7.2, the Company shall use commercially reasonable efforts to permit the Shares to be eligible forclearance and settlement through the facilities of The Depository Trust Company immediately following the termination of the Restriction Period.(c) Occurrence of Significant Event. The restrictions contained in Section 6.1(b) shall be suspended and shall not apply to or otherwise restrictthe Investor’s actions in respect of the Company’s securities for so long as a Significant Event has occurred and is continuing.6.2 Invalid Transfers. Any sale, assignment or other transfer of Covenant Shares by the Investor or any of its Affiliates, as applicable, contrary to theprovisions of this Section 6 shall be null and void, and the transferee shall not be recognized by the Company as the holder or owner of the Covenant Sharessold, assigned, or transferred for any purpose (including, without limitation, voting or dividend rights), unless and until the Investor or such Affiliate, asapplicable, has satisfied the requirements of this Section 6 with respect to such sale. The Investor shall provide the Company 10Confidential with written evidence that such requirements have been met or waived, prior to it or its Affiliates consummating any sale, assignment or other transfer ofsecurities, and no Covenant Shares shall be transferred on the books of the Company until such written evidence has been received by the Company from theInvestor. The Company, or, at the instruction of the Company, the transfer agent of the Company, may place a legend on any certificate representingCovenant Shares stating that such shares are subject to the restrictions contained in this Agreement; provided that the Company shall remove, or instruct thetransfer agent to remove, such legend upon the expiration of the Restriction Period. Upon delivery by the Investor of the written evidence required above, theCompany agrees to facilitate the timely preparation and delivery (but in no event longer than three (3) trading days) of certificates representing the CovenantShares to be sold by the Investor or any Affiliate free of any restrictive legends and in such denominations and registered in such names as the Investor orsuch Affiliate may request in connection with such sale.6.3 Performance by Affiliates. The Investor shall remain responsible for and guarantee its Affiliates’ performance in connection with this Agreement,and shall cause each such Affiliate to comply fully with the provisions of this Agreement in connection with such performance. The Investor hereby expresslywaives any requirement that the Company exhaust any right, power or remedy, or proceed directly against such an Affiliate, for any obligation orperformance hereunder, prior to proceeding directly against the Investor.SECTION 7Resales7.1 Rule 144 Reporting. With a view to making available to the Investor the benefits of certain rules and regulations of the Commission which maypermit the sale of the Shares to the public without registration, the Company agrees to use commercially reasonable efforts to:(a) Make and keep public information available, as those terms are understood and defined in Rule 144 promulgated under the Securities Act;(b) File with the Commission in a timely manner all reports and other documents required of the Company under the Exchange Act; and(c) Furnish the Investor forthwith upon request (i) a written statement by the Company as to its compliance with the public informationrequirements of said Rule 144, (ii) a copy of the most recent annual or quarterly report of the Company, and (iii) such other reports and documents as may bereasonably requested in availing the Investor of any rule or regulation of the Commission permitting the sale of any such securities without registration. 11Confidential 7.2 Restrictive Legend. The certificates representing the Shares, when issued, will bear a restrictive legend in substantially the following form:“THE SECURITIES EVIDENCED OR CONSTITUTED HEREBY HAVE BEEN ISSUED WITHOUT REGISTRATION UNDER THE SECURITIES ACTOF 1933, AS AMENDED (THE “ACT”) AND MAY NOT BE SOLD, OFFERED FOR SALE, TRANSFERRED, PLEDGED OR HYPOTHECATED WITHOUTREGISTRATION UNDER THE ACT UNLESS EITHER (i) THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL, IN FORM AND SUBSTANCEREASONABLY SATISFACTORY TO THE COMPANY, TO THE EFFECT THAT REGISTRATION IS NOT REQUIRED IN CONNECTION WITH SUCHDISPOSITION OR (ii) THE SALE OF SUCH SECURITIES IS MADE PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 144.”The legend set forth in this Section 7.2 and the related notation in the Company’s stock books shall be removed and the Company shall issue acertificate without such legend or any other legend to the holder of the Shares or issue to such holder by electronic delivery at the applicable balance accountat the Depository Trust Company, if (i) the Shares are registered for resale under the Securities Act, (ii) the Shares are sold or transferred in compliance with toRule 144, or (iii) the Shares are eligible for sale under Rule 144, without the requirement for the Company to be in compliance with the current publicinformation required under Rule 144. Following Rule 144 becoming available for the resale of Shares, without the requirement for the Company to be incompliance with the current public information required under Rule 144, the Company shall (at the Company’s expense), upon the written request ofInvestor, cause its counsel to issue to the Company’s transfer agent a legal opinion authorizing the issuance of a certificate representing the Shares withoutany restrictive or other legends, if requested by such transfer agent.SECTION 8IndemnificationEach party (an “Indemnifying Party”) hereby indemnifies and holds harmless the other party, such other party’s respective officers, directors,employees, consultants, representatives and advisers, and any and all Affiliates (as defined in Section 6.1(a)) of the foregoing (each of the foregoing, an“Indemnified Party”) from and against all losses, liabilities, costs, damages and expense (including reasonable legal fees and expenses) (collectively,“Losses”) suffered or incurred by any such Indemnified Party to the extent arising from, connected with or related to (i) breach of any representation orwarranty of such Indemnifying Party in this Agreement; and (ii) breach of any covenant or undertaking of any Indemnifying Party in this Agreement. If anevent or omission (including, without limitation, any claim asserted or action or proceeding commenced by a third party) occurs which an Indemnified Partyasserts to be an indemnifiable event pursuant to this Section 8, the Indemnified Party will provide written notice to the Indemnifying Party, setting forth thenature of the claim and the basis for indemnification under this Agreement. The Indemnified Party will give such written notice to the Indemnifying Partyimmediately after it becomes aware of the existence of any such event or occurrence. Such notice will be a condition precedent to any obligation of theIndemnifying Party to act under this Agreement but will not relieve it of its obligations under the indemnity except to the extent that the failure to provideprompt notice as provided in this Agreement prejudices the Indemnifying Party with respect to the transactions contemplated by this Agreement and to thedefense of the liability. In case any such action is brought by a third party against any Indemnified Party and it notifies the Indemnifying Party of thecommencement thereof, the Indemnifying Party will be entitled to participate therein and, to the 12Confidential extent that it wishes, to assume the defense and settlement thereof with counsel reasonably selected by it and, after notice from the Indemnifying Party to theIndemnified Party of such election so to assume the defense and settlement thereof, the Indemnifying Party will not be liable to the Indemnified Party for anylegal expenses of other counsel or any other expenses subsequently incurred by such Indemnified Party in connection with the defense thereof, provided,however, that an Indemnified Party shall have the right to employ separate counsel at the expense of the Indemnifying Party if (i) the employment thereof hasbeen specifically authorized in writing by the Indemnifying Party; or (ii) representation of both parties by the same counsel would be inappropriate due toactual or potential conflicts of interests between such parties (which such judgment shall be made in good faith after consultation with counsel). TheIndemnified Party agrees to cooperate fully with (and to provide all relevant documents and records and make all relevant personnel available to) theIndemnifying Party and its counsel, as reasonably requested, in the defense of any such asserted claim at no additional cost to the Indemnifying Party. NoIndemnifying Party will consent to the entry of any judgment or enter into any settlement with respect to any such asserted claim without the prior writtenconsent of the Indemnified Party, not to be unreasonably withheld or delayed, (a) if such judgment or settlement does not include as an unconditional termthereof the giving by each claimant or plaintiff to each Indemnified Party of a release from all liability in respect to such claim or (b) if, as a result of suchconsent or settlement, injunctive or other equitable relief would be imposed against the Indemnified Party or such judgment or settlement could materiallyand adversely affect the business, operations or assets of the Indemnified Party. No Indemnified Party will consent to the entry of any judgment or enter intoany settlement with respect to any such asserted claim without the prior written consent of the Indemnifying Party, not to be unreasonably withheld ordelayed. If an Indemnifying Party makes a payment with respect to any claim under the representations or warranties set forth herein and the IndemnifiedParty subsequently receives from a third party or under the terms of any insurance policy a sum in respect of the same claim, the receiving party will repay tothe other party such amount that is equal to the sum subsequently received.SECTION 9Miscellaneous9.1 Governing Law. This Agreement shall be governed in all respects by the laws of the State of New York as applied to agreements entered into andperformed entirely in the State of New York by residents thereof.9.2 Survival. The representations, warranties, covenants and agreements made herein shall survive any investigation made by the Investor and theClosing.9.3 Successors, Assigns. Except as otherwise provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the successors,assigns, heirs, executors and administrators of the parties hereto. This Agreement may not be assigned by either party without the prior written consent of theother; except that either party may assign this Agreement to an Affiliate (as defined in Section 6.1(a)) of such party or to any third party that acquires all orsubstantially all of such party’s business, whether by merger, sale of assets or otherwise. 13Confidential 9.4 Notices. All notices and other communications required or permitted hereunder shall be in writing and shall be sent by facsimile (receipt confirmed)or mailed by registered or certified mail, postage prepaid, return receipt requested, or otherwise delivered by hand or by messenger, addressedif to the Investor, at the following address:RPI Finance Trustc/o RP Management, LLC110 East 59th St, 33rd FloorNew York, NY 10022Attention: George LloydTelephone: (212) 883-2280E-mail: glloyd@royaltypharma.comFacsimile: (212) 883-2260with a copy to:Goodwin Procter LLP100 Northern AvenueBoston, Massachusetts 02210Attention: Arthur McGivernTelephone: 617-570-1971Facsimile: (617) 523-1231Email: AMcGivern@goodwinlaw.comif to the Company, at the following address:Cytokinetics, Incorporated280 E Grand AveSouth San Francisco, CA 94080Attention: General CounselFacsimile: (650) 624-3010with a copy to:Cooley LLP3175 Hanover St.Palo Alto, CA 94304Attention: Michael TentaTelephone: (650) 843-5636Facsimile: (650) 849-7400Email: mtenta@cooley.com 14Confidential or at such other address as one party shall have furnished to the other party in writing. All notices and communications under this Agreement shall be deemedto have been duly given (i) when delivered by hand, if personally delivered, (ii) when received by a recipient, if sent by email, (iii) when sent, if sent byfacsimile, with an acknowledgement of sending being produced by the sending facsimile machine or (iv) one Business Day following sending within theUnited States by overnight delivery via commercial one-day overnight courier service.9.5 Expenses. Each of the Company and the Investor shall bear its own expenses and legal fees incurred on its behalf with respect to this Agreementand the transactions contemplated hereby.9.6 Finder’s Fees. Each of the Company and the Investor shall indemnify and hold the other harmless from any liability for any commission orcompensation in the nature of a finder’s fee, placement fee or underwriter’s discount (including the costs, expenses and legal fees of defending against suchliability) for which the Company or the Investor, or any of its respective partners, employees, or representatives, as the case may be, is responsible.9.7 Counterparts. This Agreement may be executed in counterparts, each of which shall be enforceable against the party actually executing thecounterpart, and all of which together shall constitute one instrument.9.8 Severability. In the event that any provision of this Agreement becomes or is declared by a court of competent jurisdiction to be illegal,unenforceable or void, this Agreement shall continue in full force and effect without said provision; provided that no such severability shall be effective if itmaterially changes the economic benefit of this Agreement to any party.9.9 Entire Agreement. This Agreement and the Royalty Purchase Agreement, including the exhibits and schedules attached hereto and thereto,constitute the full and entire understanding and agreement among the parties with regard to the subjects hereof and thereof. No party shall be liable or boundto any other party in any manner with regard to the subjects hereof or thereof by any warranties, representations or covenants except as specifically set forthherein or therein.9.10 Waiver. The failure of either party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall notconstitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other party. None of the terms, covenantsand conditions of this Agreement can be waived except by the written consent of the party waiving compliance.9.11 Trustee Capacity of Wilmington Trust Company. Notwithstanding anything contained herein to the contrary, it is expressly understood andagreed by the parties hereto that (i) this Agreement is executed and delivered by Wilmington Trust Company, not individually or personally but solely in itstrustee capacity, in the exercise of the powers and authority conferred and vested in it under the trust deed of the Investor, (ii) each of the representations,undertakings and agreements herein made on the part of the Investor is made and intended not as a personal representation, undertaking and agreement byWilmington Trust Company but is made and intended 15Confidential for the purpose of binding only the Investor and (iii) under no circumstances shall Wilmington Trust Company be personally liable for the payment of anyindebtedness or expenses of the Investor or be liable for the breach or failure of any obligation, representation, warranty or covenant made or undertaken bythe Investor under this Agreement or any related documents[SIGNATURE PAGES FOLLOW] 16Confidential IN WITNESS WHEREOF, the parties have executed this Common Stock Purchase Agreement as of the date first set forth above. CYTOKINETICS, INCORPORATEDBy: /s/ Robert I. BlumName: Robert I. BlumTitle: President and CEO RPI FINANCE TRUSTBy: Wilmington Trust Company, not in its individualcapacity but solely in its capacity as owner trusteeBy: /s/ Beverly D. CapersName: Beverly D. CapersTitle: Assistant Vice President Confidential Schedule AThe Investor is an institutional “accredited investor” as defined in Rule 501(a) of Regulation D of the Securities Act. Confidential EXHIBIT ASchedule of ExceptionsNone. Exhibit 23.1CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMWe hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (Nos. 333-206795 and 333-215147) and Form S-8 (Nos.333-115146, 333-125973, 333-133323, 333-136524, 333-140963, 333-149713, 333-152850, 333-161116, 333-168520, 333-176089, 333-183091,333-190458 and 333-206101) of Cytokinetics, Incorporated of our report dated March 6, 2017 relating to the financial statements and the effectiveness ofinternal control over financial reporting, which appears in this Form 10-K./s/ PricewaterhouseCoopers LLPSan Jose, CAMarch 6, 2017Exhibit 31.1PRINCIPAL EXECUTIVE OFFICER CERTIFICATION PURSUANT TOSECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Robert I. Blum, certify that:1. I have reviewed this Annual Report on Form 10-K of Cytokinetics, Incorporated;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for theregistrant and have:a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensurethat material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularlyduring the period in which this report is being prepared;b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under oursupervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposesin accordance with generally accepted accounting principles;c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectivenessof the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscalquarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, theregistrant’s internal control over financial reporting; and5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to theregistrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonablylikely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control overfinancial reporting. By: /s/ Robert I. Blum Robert I. Blum, President, Chief Executive Officer and Director (Principal Executive Officer)Date: March 6, 2017Exhibit 31.2PRINCIPAL FINANCIAL OFFICER CERTIFICATION PURSUANT TOSECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Sharon A. Barbari, certify that:1. I have reviewed this Annual Report on Form 10-K of Cytokinetics, Incorporated;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for theregistrant and have:a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensurethat material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularlyduring the period in which this report is being prepared;b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under oursupervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposesin accordance with generally accepted accounting principles;c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectivenessof the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscalquarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, theregistrant’s internal control over financial reporting; and5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to theregistrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonablylikely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control overfinancial reporting. By: /s/ Sharon A. Barbari Sharon A. Barbari, Executive Vice President, Finance and ChiefFinancial Officer (Principal Financial Officer)Date March 6, 2017Exhibit 32.1CEO and CFO CERTIFICATIONS PURSUANT TORULE 13a-14(b) AND SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002(18 U.S.C. Section 1350)Pursuant to the requirement set forth in Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and Section 1350 ofChapter 63 of Title 18 of the United States Code (18 U.S.C. §1350), Robert I. Blum, Chief Executive Officer of Cytokinetics, Incorporated (the “Company”),and Sharon A. Barbari, Chief Financial Officer of the Company, each hereby certifies that, to the best of his or her knowledge:1. The Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2016, and to which this certification is attached as Exhibit 32.1 (the“Annual Report”), fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and2. The information contained in this Annual Report fairly presents, in all material respects, the financial condition and results of operations of the Company. By: /s/ Robert I. Blum Robert I. Blum, President, Chief Executive Officer and Director (Principal Executive Officer)By: /s/ Sharon A. Barbari Sharon A. Barbari, Executive Vice President, Finance and Chief Financial Officer (Principal Financial Officer)Date: March 6, 2017This certification accompanies the Form 10-K to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to beincorporated by reference into any filing of Cytokinetics, Incorporated under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934,as amended (whether made before or after the date of the Form 10-K), irrespective of any general incorporation language contained in such filing.

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