Fluidigm Corporation Annual Report 2016

Plain-text annual report

FLUIDIGM CORP FORM 10-K (Annual Report) Filed 03/03/17 for the Period Ending 12/31/16 Address Telephone CIK Symbol SIC Code Industry 7000 SHORELINE COURT SUITE 100 SOUTH SAN FRANCISCO, CA 94080 6502666000 0001162194 FLDM 3826 - Laboratory Analytical Instruments Advanced Medical Equipment & Technology Sector Healthcare Fiscal Year 12/31 http://www.edgar-online.com © Copyright 2017, EDGAR Online, Inc. All Rights Reserved. Distribution and use of this document restricted under EDGAR Online, Inc. Terms of Use. UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549______________________________________FORM 10-K(Mark One)x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2016Or¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period from to Commission file number: 001-34180______________________________________FLUIDIGM CORPORATION(Exact name of registrant as specified in its charter)Delaware 77-0513190(State or other jurisdiction ofincorporation or organization) (I.R.S. EmployerIdentification Number)7000 Shoreline Court, Suite 100South San Francisco, California 94080(Address of principal executive offices) (Zip Code)(650) 266-6000Registrant’s telephone number, including area codeSecurities registered pursuant to Section 12(b) of the Act:Title of each class Name of each exchange on which registeredCommon Stock, $0.001 Par Value per Share The NASDAQ Global Select MarketPreferred Share Purchase Rights Securities registered pursuant to Section 12(g) of the Act:None______________________________________Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act of 1933, as amended. Yes ¨ No xIndicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934, asamended. Yes ¨ No xIndicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 duringthe preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for thepast 90 days. Yes x No ¨Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required tobe submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required tosubmit and post such files). Yes x No ¨Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the bestof the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to thisForm 10-K. xIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See thedefinitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.Large accelerated filer ¨ Accelerated filer xNon-accelerated filer ¨ (Do not check if a smaller reporting company) Smaller reporting company ¨Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨ No xAs of June 30, 2016, the last business day of the registrant’s most recently completed second fiscal quarter, the aggregate market value of voting and non-voting common equity held by non-affiliates of the registrant was approximately $262,199,821 (based on a closing sale price of $9.03 per share as reported for theNASDAQ Global Select Market on June 30, 2016). Shares of common stock held by each executive officer and director and by each other person who may bedeemed to be an affiliate of the Registrant have been excluded from this computation. The determination of affiliate status for this purpose is not necessarily aconclusive determination for other purposes.The number of shares of the registrant’s common stock, $0.001 par value per share, outstanding as of February 10, 2017 was 29,208,481.______________________________________DOCUMENTS INCORPORATED BY REFERENCEThe information called for by Part III of this Annual Report on Form 10-K will be included in an amendment to this Form 10-K or incorporated by referencefrom the registrant’s definitive Proxy Statement relating to its 2017 Annual Meeting of Stockholders. Fluidigm CorporationFiscal Year 2016Form 10-KAnnual Report______________________________________TABLE OF CONTENTS PagePART I ITEM 1. BUSINESS 1ITEM 1A. RISK FACTORS 15ITEM 1B. UNRESOLVED STAFF COMMENTS 40ITEM 2. PROPERTIES 40ITEM 3. LEGAL PROCEEDINGS 40ITEM 4. MINE SAFETY DISCLOSURE S 40 PART II ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS ANDISSUER PURCHASES OF EQUITY SECURITIES 41ITEM 6. SELECTED FINANCIAL DATA 43ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OFOPERATIONS 44ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK 57ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA 58ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIALDISCLOSURE 91ITEM 9A. CONTROLS AND PROCEDURES 91ITEM 9B. OTHER INFORMATION 91 PART III ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE 92ITEM 11. EXECUTIVE COMPENSATION 92ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATEDSTOCKHOLDER MATTERS 92ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE 92ITEM 14. PRINCIPAL ACCOUNTING FEES AND SERVICES 92 PART IV ITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES 93 iSpecial Note Regarding Forward-looking Statements and Industry DataThis Form 10-K contains forward-looking statements that are based on our management’s beliefs and assumptions and on information currently available toour management. The forward-looking statements are contained principally in the sections entitled “Business,” “Risk factors,” and “Management’s discussion andanalysis of financial condition and results of operations.” Forward-looking statements include information concerning our possible or assumed future results ofoperations, cash flow, sources of revenue, operating and other expenses, unit sales, business strategies, expansion of our business, financing plans, competitiveposition, industry environment, potential growth opportunities, and the effects of competition. Forward-looking statements include statements that are not historicalfacts and can be identified by terms such as “anticipates,” “believes,” “could,” “seeks,” “estimates,” “expects,” “intends,” “may,” “plans,” “potential,” “predicts,“projects,” “should,” “will,” “would,” or similar expressions and the negatives of those terms.Forward-looking statements involve known and unknown risks, uncertainties, and other factors that may cause our actual results, performance, orachievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. We discussthese risks in greater detail in the section entitled “Risk factors” and elsewhere in this Form 10-K. Given these uncertainties, you should not place undue relianceon these forward-looking statements.Forward-looking statements represent our management’s beliefs and assumptions only as of the date of this Form 10-K. Except as required by law, weassume no obligation to update these forward-looking statements, or to update the reasons actual results could differ materially from those anticipated in theseforward-looking statements, even if new information becomes available in the future. You should read this Form 10-K completely and with the understanding thatour actual future results may be materially different from what we expect.____________________________“Fluidigm,” the Fluidigm logo, “Access Array,” “Biomark,” “C1,” “Callisto,” “Cell-ID,” “CyTOF,” “D3,” “Delta Gene,” “Digital Array,” “Dynamic Array,”“EP1,” “FC1,” “Flex Six,” “Helios,” “High-Precision 96.96 Genotyping,” “Hyperion,” “Juno,” “Maxpar,” “MSL,” “Nanoflex” “Open App,” “Polaris,” “qdPCR37K,” “Script Builder,” “Script Hub,” “Singular,” “SNP Trace” and “SNP Type” are trademarks or registered trademarks of Fluidigm Corporation. Other servicemarks, trademarks and trade names referred to in this Form 10-K are the property of their respective owners.____________________________Unless the context requires otherwise, references in this Annual Report on Form 10-K to “Fluidigm,” the “Company,” “we,” “us,” and “our” refer toFluidigm Corporation and its subsidiaries.PART IITEM 1. BUSINESSOverviewWe create, manufacture, and market innovative technologies and tools for life sciences research. We sell instruments and consumables, including integratedfluidic circuits, or IFCs, assays and reagents, to academic institutions, clinical research laboratories, and biopharmaceutical, biotechnology, and agriculturalbiotechnology, or Ag-Bio, companies and contract research organizations, or CROs. Our technologies and tools are directed at the analysis of deoxyribonucleicacid, or DNA, ribonucleic acid, or RNA, and proteins in a variety of different sample types, from individual cells to bulk tissue.We were a pioneer in the application of microfluidics to enable high-throughput and highly-multiplexed polymerase chain reactions, or PCR, for geneticanalysis, as well as a field known as single-cell genomics, in which the genetic composition of individual cells is assayed. In February 2014, we purchased DVSSciences, Inc., whose mass cytometry system enables the highly-multiplexed analysis of cellular surface and intracellular proteins in both blood and tissue.Researchers have successfully employed our products to help achieve breakthroughs in a variety of fields, including single-cell gene and protein expression,gene regulation, genetic variation, cellular function and applied genetics. These breakthroughs include using our systems to help detect life-threatening mutationsin cancer cells, discover cancer associated biomarkers, analyze the genetic composition of individual stem cells and assess the quality of agricultural products, suchas seeds or livestock.Our TechnologyMulti-Layer Soft LithographyOur IFCs are manufactured using multi-layer soft lithography technology, or MSL technology, to create valves, chambers, channels and other fluidiccomponents on our IFCs that allow nanoliter quantities of fluids to be precisely manipulated within the IFC. We have developed commercial manufacturingprocesses to fabricate valves, channels, vias, and chambers with dimensions in the ten to 100 micron range, at high density and with high yields.Integrated Fluidic CircuitsOur IFCs incorporate several different types of technology that together enable us to use MSL technology to rapidly design and deploy new microfluidicapplications. The first level of our IFC technology is a library of components that perform basic microfluidic functions, such as pumps, mixers, single-cell capturechambers, separation columns, control logic, and reaction chambers. The second level of our IFC technology comprises the architectures we have designed toexploit our ability to conduct thousands of reactions on a single IFC. The third level of our IFC technology involves the interaction of our IFCs with the actuallaboratory environment. Our IFCs are built on specially designed input frames that are compatible with most commonly used laboratory systems.Instrumentation and SoftwareWe have developed instrumentation technology to load samples and reagents onto our IFCs and to control and monitor reactions within our IFCs. Our line ofIFC controllers consists of commercial pneumatic components and both custom and commercial electronics. They apply precise control of multiple pressures tomove fluid and control valve states in a microfluidic IFC.Our Biomark HD system includes our custom thermal cycler, the FC1 cycler, and a sophisticated fluorescence imaging system. Our EP1 instrument is afluorescence reader designed for end-point imaging, suitable for genotyping and digital PCR applications. Our C1 system combines the hardware elements of ourIFC controllers and FC1 cycler with sophisticated scripting and protocol control software to enable automation of single-cell capture and preparation forsubsequent analysis. Certain capabilities of the C1 system have been used to create our Juno system, which serves as a universal controller and cycler for ourDynamic Array IFCs. Our Callisto system integrates environmental regulation for long-term cell culture with the C1 control system. Our Polaris system combinesthe capabilities of all these instruments by incorporating thermal cycling, IFC control, environmental regulation, and imaging.1Our mass cytometry instrumentation technology includes a custom-designed inductively-coupled plasma ion source, ion-optical and vacuum systems, andinstrument control electronics. With our CyTOF 2 system and our Helios system, which is an enhanced version of our CyTOF 2 system, individual cells areatomized, ionized, and extracted. A time-of-flight mass analyzer separates atomic ions of different mass-to-charge ratios, providing information on temporaldistribution of ions.We have also developed specialized software to manage and analyze the unusually large amounts of data produced by our systems. Our bioinformatictoolset, the Singular software, facilitates the analysis and visualization of single-cell gene expression data. More recently, we extended the scope of the toolset toinclude DNA analysis tools. We also developed the C1 Script Builder software to enable customers to take full advantage of the flexibility of C1 IFC architectureby allowing them to program their own control scripts for the C1 system. We offer Fluidigm Cytobank, our cloud-based platform of analytical tools, for use withthe Helios/CyTOF 2 systems.Assays and ReagentsOur Delta Gene and single-nucleotide polymorphism type, or SNP Type, assay products consist of assay design and custom content delivery systems forgene expression and genotyping, respectively. These offerings provide low-cost alternatives to chemistries such as TaqMan, and allow customers to use IFCs inmore flexible ways. PCR assay reagents need to be specific to the gene targets of interest but the process of designing a set of assays may delay the implementationexperiments or require the use of expensive pre-designed assays. We have developed a process to provide customers with validated assays for their targets ofinterest.We also manufacture metal-conjugated antibodies for use with our Helios/CyTOF 2 system to allow detection of up to approximately 37 protein targetssimultaneously in a single cell. Our metal-conjugated antibodies are manufactured using metal-chelating polymers, which are produced using proprietarypolymerization processes and subsequent post-polymerization modifications.ProductsWe market innovative technologies and life-science tools, including preparatory and analytical instruments for High Throughput Genomics, Single CellGenomics, Mass Cytometry and consumables, including IFCs, assays, and reagents. Our primary product offerings are summarized in the table below:Product Product Description ApplicationsHigh Throughput Genomics Preparatory Instruments: Access Array System A modular, flexible system that automates amplicon-basedlibrary preparation of up to 480 amplicons across 48unique samples per processing run. The resulting barcodedlibraries are ready for targeted DNA sequencing on next-generation sequencing (NGS) platforms from Illumina®,Ion Torrent®, and other suppliers. Library preparation for targeted DNAsequencing on NGS systems. 2Product Product Description Applications Juno System An integrated system that automates the preparation ofamplicon-based libraries for targeted DNA next-generationsequencing, as well as the preparation of samples forgenomic analysis.Microfluidic processing automates parallel PCR-basedtarget enrichment, barcoding, and tagging of libraries foreach sample within the processing run. Multiplexingchemistry facilitates parallel amplification of up to 5000targets from each of 48 samples, or up to 2500 targets fromeach of 192.Additionally, Juno automates workflows for PCR-basedgene expression and genotyping by assembling andcontrolling reactions at the nanoliter scale, and enablingpreamplification within the IFC for the genotyping ofchallenging and low-concentration DNA samples. Library preparation for targeted DNAsequencing on NGS systems.End-Point PCR, SNP Genotyping andGene Expression Callisto System Integrated system with environmental control and IFC thatenables long term automated cell culture and combinatorialdosing on a single device. Stem Cell Reprogramming andDifferentiation Analytical Instruments: Biomark HD System Real-time PCR analytical instrument for high-throughputgene expression analysis, single-cell targeted geneexpression analysis, microRNA analysis, SNP genotyping,and digital PCR. SNP Genotyping, Digital PCR, and GeneExpression, including Single-CellTargeted Gene Expression EP1 System End-point PCR analytical instrument that performs high-throughput SNP genotyping and end-point digital PCR. SNP Genotyping and Digital PCR Integrated Fluidic Circuits (IFCs): Access Array IFC IFC that facilitates parallel amplification, barcoding, andtagging of 48 unique samples and designed to enablerecovery of reaction products from the IFC for sequencing. Library preparation for targeted DNAnext-generation sequencing Juno Genotyping IFC IFC that incorporate preamplification for genotyping ofchallenging and low-concentration DNA samples. Supportsgenotyping of up to 96 samples and 96 samples on a singlerun. Dynamic Array IFCs IFCs based on matrix architecture, allowing users to (i)individually assay up to 48 samples against up to 48assays, (ii) individually assay up to 96 samples against upto 96 assays, or (iii) individually assay up to 192 samplesagainst up to 24 assays. Real-time qPCR, End-Point PCR, SNPGenotyping and Gene Expression,including Single-Cell Targeted GeneExpression Digital Array IFCs IFCs based on partitioning architecture, allowing users todivide samples into up to 770 chambers in each of up to 48panels for up to 36,960 reactions per IFC. Digital PCR, Copy Number VariationandVariant Detection3Product Product Description Applications Flex Six IFC IFC that incorporates six 12 X 12 partitions that can beorganized in any configuration, in up to six separateexperimental runs. Gene Expression and SNP Genotyping Callisto IFC IFC that enables combinatorial dosing and culture of livecells. It enables simultaneous incubation of 32 independentcell chambers containing 100-1000 cells per chamber. Eachchamber can be dosed with up to 16 variables includingtranscription factors, RNA, viruses, bacteria or smallmolecules. Cell reprogramming and differentiation Assays and Reagents: Delta Gene and SNP Type Assays Custom designed assays for specific nucleic acid regions ofinterest, providing optimized assays, content, and servicesto users of Biomark and EP1 systems at lower cost ascompared to other commercially available chemistries. Gene Expression, Single-Cell TargetedGene Expression, and SNP Genotyping Access Array Target-Specific Primers andTargeted Sequencing Prep Primers Custom designed amplicon-library preparation assays foruse with Access Array IFCs on the Access Array or Junosystems. Targeted Sequencing withNext-Generation DNASequencing Targeted DNA Seq Library Assays Custom designed amplicon-library preparation assays foruse with LP IFCs on the Access Array or Juno systems. Single Cell Genomics Preparatory Instrument: C1 Single-Cell System Sample preparation system that rapidly and reliablyisolates and processes individual cells for genomicanalysis. Single-Cell Targeted Gene Expression,Single-Cell microRNA Analysis, Single-Cell mRNA Sequencing, Single-CellTargeted DNA Sequencing, Single-CellWhole Exome Sequencing, and Single-Cell Whole Genome DNA Sequencing,Single-Cell Epigenetics. Preparatory Analytical Instruments: Polaris System System and IFC that incorporate cell selection, isolation,imaging, dosing, culture, and processing of single cells fordownstream molecular biology preparation into a singleworkflow. Functional Genomics Using Single-CellmRNA Sequencing 4Product Product Description Applications C1 IFCs IFCs that capture up to 800 cells between 5-25 microns indiameter and then automatically process the cells for avariety of genomic analysis using thermal and pneumaticcontrols at nanoliter scale. Includes Open App IFC thatallows users to design their own custom assays on up to 96captured single cells. Single-Cell Targeted Gene Expression,Single-Cell microRNA Analysis, Single-Cell mRNA Sequencing, Single-CellTargeted DNA Sequencing, Single-CellWhole Exome DNA Sequencing, andSingle-Cell Whole Genome DNASequencing. Additional customer and 3 rd-party developed applications availablethrough Fluidigm Script Hub Polaris IFC IFC that selects, captures and cultures up to 48 single-cellsfor 24 hours or less. It integrates media exchange, dosingand time course studies followed by cell lysis, reversetranscriptons and library preparation for single cell mRNAsequencing. Functional Genomics of Single Cells Mass Cytometry Analytical Systems: Helios/CyTOF 2 System Mass cytometry instrument that performs high-parametersingle-cell protein analysis by analyzing cells labeled witha panel of reagents conjugated to stable metal isotopes. Single-Cell Protein Analysis Assays and Reagents: Maxpar Reagents Pre-conjugated metal-labeled antibodies for functional andphenotypic profiling of single cells, application specificpanel kits, and reagents for custom antibody labeling andnucleic acid staining. Single-Cell Protein Analysis 5We have announced the following new products, which we expect will be commercially available in the near future (as indicated below):Product Product Description Applications Imaging Mass Cytometer (IMC) instrument andreagents New platform instrument that enables simultaneousmeasurements of more than 35 proteins in complex tissuesamples, including formalin-fixed paraffin-embeddedtissues, deposited on a microscope slide, with spatialresolution provided by analysis of individual onemicrometer pixels. The platform consists of a laser ablationmodule, capable of generating non-overlapping single shotablation plumes at a frequency of 100 Hz and higher, andHelios system. The laser ablation module is compatiblewith existing Helios system installations. Research into system biology of solidtumors, such as breast cancer, pancreaticcancer, lung cancer Laser Ablation Module When connected to a Helios system, provides a solution forthe growing need to conduct high-parameter imaging tocomplement existing single-cell genomics and proteomicstechniques by providing spatial context. Spatial analysis of complex tissuesamples and smeared cells on slides. Market OpportunityThe current markets for our products include genomics and proteomics, predominantly among academic life science research customers, but also in variousapplied markets customers, such as clinical research laboratories, biopharmaceutical companies, biorepositories and agricultural biotechnology entities.Markets:GenomicsOne primary area of focus within life science research is genetic analysis, the study of genes and their functions. The hereditary material or nucleic acid of anorganism is often referred to as its genome, the protein-encoding regions of which are commonly known as genes. Analysis of variations in genomes, genes andgene activity in and between organisms can provide valuable insight into their health and functioning. Single-cell genomics is the study of the sequence andexpression of genes and their ultimate functions at the individual cell level.There are several forms of genetic analysis in use today, including genotyping, gene expression analysis and DNA sequencing.•Genotyping involves the analysis of DNA variations across individual genomes. There are multiple forms of variants, including single nucleotidepolymorphism, or SNPs, insertion-deletions and copy number variation. A common application of genotyping focuses on analyzing SNPs to determinewhether a SNP or group of SNPs are associated with a particular genetic trait, such as propensity for a disease.•Gene expression analysis involves measuring the levels of particular ribonucleic acid sequences known as messenger RNAs, or mRNAs, which havebeen transcribed from genes. Determining these levels is important because mRNAs are often translated by the cell into proteins, and may affect theactivity of the cell or the larger organism. •DNA sequencing is a process by which researchers are able to determine the particular order of nucleotide bases that comprise all or a portion of aparticular gene or genome, and typically improves with target enrichment, such as complex sample preparation and tagging processes. Researchers areincreasingly using next-generation DNA sequencers to rapidly and cost-effectively sequence portions of genomes, which is important for theidentification of genetic variations that correlate with particular phenotypes.6Gene expression and genotyping are studied through a combination of various technology platforms that characterize gene function and genetic variation.These platforms often rely on PCR, amplification to generate exponential copies of a DNA sample to provide sufficient signal to facilitate detection. Real-timequantitative PCR, or real-time qPCR, is a more advanced form of PCR that makes it possible to quantify the number of copies of DNA present in a sample.ProteomicsAnother focus within life science research is protein analysis, the study of proteins and their structures and functions. Proteins perform a vast array offunctions within living organisms, including catalyzing metabolic reactions, replicating DNA, signaling response to stimuli and transporting molecules from onelocation to another. Protein analysis is required to profile and understand cellular function as well as the interaction in tissues and other complexmicroenvironments.There are several forms of high-throughput protein analysis in use today, including mass spectrometry, traditional flow cytometry, immunohistochemistryand both suspension and imaging mass cytometry.•Mass spectrometry is an analytical chemistry technique that measures the mass-to-charge ratio in molecules using external electric and magnetic fields.Mass spectrometry techniques are limited to bulk samples and provide an understanding of global protein dynamics on a tissue or organism level, butdoes not alone enable researchers to analyze data at a single cell level.•Traditional flow cytometry utilizes a suspension of cells in a stream of fluid and passes them through an electronic detection apparatus to allowsimultaneous multi-parameter analysis of the physical and chemical characteristics of up to thousands of cells per second. Although traditional flowcytometry technologies are high-throughput with single-cell analysis capabilities, a key limitation is the use of fluorescent dyes to label antibodies fordetection. These fluorescent labels have emission spectra that typically overlap, making it challenging to optimize reagents to analyze many proteinmarkers at once. In general, the number of protein targets for conventional flow cytometry is less than about 10 with significant reagent optimizationoften involved.•Immunohistochemistry is a method by which cells in a tissue section are stained with antibodies and then imaged with a conventional or fluorescentmicroscope. Antibodies selected to bind to proteins of interest can be conjugated with either chromogenic or fluorescent labels, allowing cellular proteinsto be visualized in spatial context. Immunohistochemistry is used broadly throughout the life sciences industry, and in clinical diagnostics, to diagnoseand better understand the characteristics and relationship of cancerous versus normal cells in biopsy tissue. In general, the number of simultaneouslyimageable proteins is less than five, with researchers only able to achieve a higher-parameter resolution using serial sections (several adjacent sections ofthe same tissue) or other highly laborious, more serial staining methods.•Suspension mass cytometry is similar to traditional flow cytometry but is based primarily on antibodies using heavy metal isotope labels rather thanfluorescent labels for detection of proteins, enabling the significant expansion of the number of parameters analyzed per individual cell versusconventional flow cytometry technologies. With high-throughput, single-cell analysis capabilities and the ability to analyze more protein markers perindividual cell, researchers have more granular information, which allows them to identify and characterize even finer subpopulations of cells.•Imaging mass cytometry is similar to immunohistochemistry, but is also based primarily on antibodies using heavy metal isotope labels rather thanfluorescent or chromogenic labels for detection of proteins. This method enables a significant expansion of the number of parameters simultaneouslyanalyzed per tissue section rather than in adjacent sections or via serial staining protocols.Customer Types:Academic Life Science Research . A large portion of global life science research takes place in academic settings, including universities, publicly orphilanthropically funded institutes, research hospitals and government-funded agencies. The activities conducted by these customers spans the entire range ofproducts and services and are generally directed at producing new basic or translational biology insights for publication or presentation in peer-reviewed journalsand forums. Many of the key breakthroughs in biological science employed or modified by clinical research laboratories, biopharmaceutical and other appliedmarkets transpire first in the academic research setting.7Clinical Research Laboratories . Recent advances in genetic analysis technology are increasingly being used for clinical research applications. Techniquessuch as SNP genotyping, gene expression analysis, targeted DNA sequencing and other genetic correlation studies, have been developed to identify diseasesusceptibility and to diagnose, classify and monitor disease progression. Prognostics and diagnostics based on measuring these genetic markers have the potentialto be much more accurate and robust than conventional diagnostics. The validation and translation of prognostics and diagnostics into clinically available testsoften requires life science automation systems that are able to measure multiple biomarkers efficiently in a large number of patient samples.Biopharmaceuticals. Biopharmaceutical companies use production scale genomic and proteomic analytical methods in numerous phases of the discovery,development and the approval process of a therapeutic agent. These methods also may be used in companion diagnostics to attempt to reduce adverse events andidentify patient populations that may more effectively respond to a therapeutic agent.Biorepositories . Advancements in biology have led to an increased dependence on biorepositories to store genetic material for future testing and analysis.Flaws in the identity and quality of biorepository specimens are costly and result in erroneous data. To ensure sample integrity, biorepositories require cost-effective, simple and high-throughput techniques to identify DNA samples and ensure traceability throughout the banking and downstream analytical processes.Agricultural Biotechnology . Ag-Bio applies scientific techniques, including genetic analysis techniques, such as SNP genotyping and DNA sequencing, tostudy and improve desired characteristics in plants, animals and microorganisms. Genetic analysis techniques have become increasingly useful in Ag-Bioapplications, including wildlife population studies, agricultural quality control, and commercial genetic engineering and identification. Ag-Bio customers requiresystems that can quickly and accurately analyze a large number of samples, such as tissue from livestock populations or seeds from a production lot, in a high-throughput and cost-efficient manner.Fluidigm’s StrategyKey elements of our strategy include:•Offer innovative, differentiated products to researchers based on our microfluidic and mass cytometry technologies. Our microfluidic technologies enable a scalable and sensitive solution in fields requiring high-throughput genomic analysis, whether this be for the analysisof gene expression profiles, genotyping or library preparation in advance of gene sequencing. Microfluidic solutions also enable single-cell genomic analysisacross a broad menu of applications. Mass cytometry is a leading solution to analyze many cell-surface and intracellular proteins simultaneously in cellsuspensions and tissues. Our products enable innovative methods to characterize cells and other sample types not commonly achieved with other technologyanalogues.•Expand addressable markets through attention to assay content, workflow efficiency, software improvements, and desirable strategic partnerships . Our strategy devotes attention to building out applications, workflows and analytics to allow our customers better productivity, increasing the value of ourtoolsets. We have internally-developed and externally-partnered to enable our C1 system to enable the widest breadth of single-cell applications currently in themarketplace. Our content development strategy also includes our high-throughput genomics platforms for gene expression, genotyping and sequencing librarypreparations as well as our mass cytometry franchise. Our future assay development will leverage both in-house informatics as well as externally-partneredsolutions to drive towards sample-to-answer functionality across all our platforms.Marketing, Sales, Service and SupportWe distribute our systems through our direct sales force and support organizations located in North America, Europe, and Asia-Pacific, and throughdistributors or sales agents in several European, Latin American, Middle Eastern, and Asia-Pacific countries. Our sales and marketing efforts are targeted atlaboratory directors and principal investigators at leading companies and academic institutions who need reliable life science automation solutions or enabling newsingle-cell genomics and mass cytometry technologies for research or commercial purposes. 8Our sales process often involves numerous interactions and demonstrations with multiple people within an organization. Some potential customers conductin-depth evaluations of the system, including running experiments on our system and competing systems. In addition, in most countries, sales to academic orgovernmental institutions require participation in a tender process involving preparation of extensive documentation and a lengthy review process. As a result ofthese factors and the budget cycles of our customers, our sales cycle, the time from initial contact with a customer to our receipt of a purchase order, can often be12 months or longer.As of December 31, 2016 , we had 198 people employed in sales, technical support, and marketing, including 92 sales representatives and applicationsspecialists located in the field.CustomersWe sell our instruments to leading academic research institutions, clinical research laboratories, and biopharmaceutical, biotechnology and Ag-Biocompanies. No single customer represented more than 10% of our total revenue for 2016 , 2015 , or 2014 .ManufacturingOur manufacturing operations are primarily located in Singapore and Canada. Our facility in Singapore manufactures our genomics instruments, several ofwhich are assembled at facilities of our contract manufacturers in Singapore, with testing and calibration of the assembled products performed at our Singaporefacility. All of our IFCs for commercial sale and some IFCs for our research and development purposes are also fabricated at our Singapore facility. Our masscytometry instruments for commercial sale, as well as for internal research and development purposes, are manufactured at our facility in Canada. We alsomanufacture assays and reagents at our facilities in the United States.We rely on a limited number of suppliers for certain components and materials used in our products. Key components in our products that are supplied bysole or limited source suppliers include a specialized polymer and other specialized materials from which our IFC cores are fabricated, specialized custom cameralenses, fiber light guides, and other components required for the reader of our Biomark system; specialized pneumatic and electronic components for our C1, Juno,Callisto and Polaris systems, the electron multiplier detector included in, and the nickel sampler cone and certain metal isotopes used with, our Helios/CyTOF 2system; and certain raw materials for our Delta Gene and SNP Type assays and Access Array Target-Specific primers. The loss of a single or sole source supplierwould require significant time and effort to locate and qualify an alternative source of supply, if at all, and could adversely impact our business. For additionalinformation, please see the section entitled “Risk factors” in Part I, Item 1A of this Form 10-K.Research and DevelopmentWe have assembled experienced research and development teams at our South San Francisco, California, Markham, Ontario, Canada, and Singaporelocations with the scientific, engineering, software, bioinformatic, and process talent that we believe is required to grow our business.The largest component of our current research and development effort is in the areas of new products and new applications. We developed a high-throughputC1 IFC (HT IFC) for handling up to 800 medium sized cell types applied to the work-flows of the Fluidigm installed base instruments. In the area of masscytometry, we developed an initial prototype imaging mass cytometer instrument in 2016. The imaging mass cytometer system provides spatial resolution ofprotein expression in complex tissue samples at the single-cell level, quantitative measurement using metal isotope tags, and analysis of more than 35 proteins. Theimaging mass cytometer system is in early-access commercial availability, with later expanded commercial availability. We also invest significantly in researchand development efforts to expand our single-cell and production genomics applications. For example, we continue to develop various panel sets for cancerresearch for use with our systems.The second component of our research and development effort is to continuously develop new manufacturing processes and test methods to drive downmanufacturing cost, increase manufacturing throughput, widen fabrication process capability, and support new microfluidic devices and designs.Our research and development expenses were $38.4 million , $39.3 million, and $43.4 million in 2016, 2015, and 2014, respectively. As of December 31,2016 , 131 of our employees were engaged in research and development activities.9CompetitionThe life science markets are highly competitive and expected to grow more competitive with the increasing knowledge gained from ongoing research anddevelopment. We believe that the principal competitive factors in our target markets include cost of capital equipment and supplies; reputation among customers;innovation in product offerings; flexibility and ease of use; accuracy and reproducibility of results; and compatibility with existing laboratory processes, tools, andmethods.We compete with both established and development stage life science companies that design, manufacture, and market instruments for gene expressionanalysis, genotyping, other nucleic acid detection, protein expression analysis, and additional applications. In addition, a number of other companies and academicgroups are in the process of developing novel technologies for life science markets. Many of our competitors enjoy several competitive advantages over us,including significantly greater name recognition; greater financial and human resources; broader product lines and product packages; larger sales forces andeCommerce channels; larger and more geographically dispersed customer support organization; substantial intellectual property portfolios; larger and moreestablished customer bases and relationships; greater resources dedicated to marketing efforts; better established and larger scale manufacturing capability; andgreater resources and longer experience in research and development. For additional information, please see the section entitled “Risk factors” in Part I, Item 1A ofthis Form 10-K.To successfully compete with existing products and future technologies, we need to demonstrate to potential customers that the cost savings and performanceof our technologies and products, as well as our customer support capabilities, are superior to those of our competitors. To differentiate our company from other,larger enterprises, we need to introduce new and innovative offerings regularly and maintain a well-staffed commercial team “in the field” to successfullycommunicate the advantages of our products and overcome potential obstacles to acceptance of our products. In addition, ongoing collaborations and partnershipswith key opinion leaders are desirable to demonstrate both innovation and applicability of our products. Intellectual PropertyPatents We have developed a portfolio of issued patents and patent applications directed to commercial products and technologies in development. As ofDecember 31, 2016 , we owned or licensed over 600 patents and we had approximately 300 pending patent applications worldwide. Our patents have expirationdates ranging from 2017 to 2033.License AgreementsWe have entered into licenses for technologies from various companies and academic institutions. Microfluidic Technologies. Our core microfluidics technology originated at the California Institute of Technology, or Caltech, in the laboratory of ProfessorStephen Quake, who is a co-founder of Fluidigm. We license microfluidics technology from Caltech, Harvard University, and Caliper Life Sciences, Inc., whichsubsequently became a PerkinElmer company, referred to as Caliper.•We exclusively license from Caltech relevant patent filings relating to developed technologies that enable the production of specialized valves andpumps capable of controlling fluid flow at nanoliter volumes. The license agreement will terminate as to each country and licensed product uponexpiration of the last-to-expire patent covering licensed products in each country. The U.S. issued patents we have licensed from Caltech expirebetween 2017 and 2030.•We have entered into a co-exclusive license agreement with Harvard University for the license of relevant patent filings relating to microfluidictechnology. The license agreement will terminate with the last-to-expire of the licensed patents. The U.S. issued patents we have licensed from HarvardUniversity expire between 2019 and 2027.•In May 2011, we entered into a license agreement with Caliper to license Caliper’s existing patent portfolio in certain fields. The license agreement willterminate with the last-to-expire of the licensed patents. As later amended, the license agreement provides for certain royalty payments until mid-2018for our existing products at the time of amendment and their future equivalents.10Instrumentation and Digital PCR. On June 30, 2011, we settled litigation and entered into a series of patent cross-license and sub-license agreements withLife Technologies Corporation (now part of Thermo Fisher Scientific) and its subsidiary Applied Biosystems, LLC, referred to as Life. The agreements involve across-license concerning our imaging readers and other patent filings and certain of Life’s patent families relating to methods and instruments for conductingnucleic acid amplification, such as with PCR; a sub-license that provides us access to certain of Life’s digital PCR patents; and a sublicense that provides Lifeaccess to certain of our non-core technology patents licensed from Caltech. In July 2011, pursuant to the terms of the agreements, we paid Life $2.0 million inconnection with our exercise of an option to preclude Life from initiating litigation under its patents existing as of June 30, 2011 against our customers for twoyears and against our company, with respect to our current products and equivalent future products, for four years, subject to certain exceptions. The licenseagreement will terminate with the last-to-expire of the licensed patents, which is expected to be in 2028.Mass Cytometry. Some of the intellectual property rights covering our mass cytometry products were subject to a license agreement, referred to as theOriginal License Agreement, between Fluidigm Canada Inc., referred to as Fluidigm Canada, and PerkinElmer Health Sciences, Inc., referred to as PerkinElmer.Under the Original License Agreement, Fluidigm Canada received an exclusive, royalty bearing, worldwide license to certain patents owned by PerkinElmer in thefield of inductively coupled plasma, or ICP-based mass cytometry, including the analysis of elemental tagged materials in connection therewith, referred to as thePatents, and a non-exclusive license for reagents outside the field of ICP-based mass cytometry. On November 4, 2015, we entered into a patent purchaseagreement with PerkinElmer pursuant to which we purchased the Patents for a purchase price of $6.5 million and a patent assignment agreement pursuant to whichPerkinElmer transferred and assigned to us all rights, title, privileges, and interest in and to the Patents and the Original License Agreement. Accordingly, we haveno further financial obligations to PerkinElmer under the Original License Agreement. Contemporaneously with the purchase of the Patents, we entered into alicense agreement with PerkinElmer pursuant to which we granted PerkinElmer a worldwide, non-exclusive, fully paid-up license to the Patents in fields other than(i) ICP-based mass analysis of atomic elements associated with a biological material, including any elements that are unnaturally bound, directly or indirectly, tosuch biological material (Mass Analysis) and (ii) the development, design, manufacture, and use of equipment or associated reagents for such Mass Analysis. Thelicense will terminate on the last expiration date of the Patents, currently expected to be in December 2025, unless earlier terminated pursuant to the terms of thelicense agreement.Any loss, termination, or adverse modification of our licensed intellectual property rights could have a material adverse effect on our business, operatingresults, and financial condition. For additional information, please see the section entitled “Risk factors” in Part I, Item 1A of this Form 10-K.OtherIn addition to pursuing patents and licenses on key technologies, we have taken steps to protect our intellectual property and proprietary technology byentering into confidentiality agreements and intellectual property assignment agreements with our employees, consultants, corporate partners, and, when needed,our advisers.Government RegulationOur products are currently labeled and sold for research purposes only, and we sell them to academic institutions, life sciences and clinical researchlaboratories that conduct research, and biopharmaceutical and biotechnology companies for non-diagnostic and non-clinical purposes. Our products are notintended for use in clinical practice in the diagnosis of disease or other conditions, and they are labeled for research use only. Accordingly, they are subject only tolimited, specific regulation with respect to labeling by the U.S. Food and Drug Administration, or FDA. In particular, while FDA regulations require that researchuse only products be labeled, “For Research Use Only. Not for use in diagnostic procedures,” or RUO products, the regulations do not subject such products to theFDA’s broader pre- and post-market controls for medical devices.In November 2013, the FDA issued a final guidance document stating that merely including a labeling statement that the product is for research purposesonly will not necessarily render the device exempt from the FDA’s clearance, approval, or other regulatory requirements if the totality of circumstancessurrounding the distribution of the product indicate that the manufacturer knows its product is being used by customers for diagnostic uses or the manufacturerintends such a use. These circumstances may include, among other things, written or verbal marketing claims regarding a product’s performance in clinicalapplications and a manufacturer’s provision of technical support for such activities. In the future, certain of our products or related applications could becomesubject to regulation as medical devices by the FDA. If we11wish to label and market our products for use in performing clinical diagnostics, thus subjecting them to regulation by the FDA under premarket and postmarketcontrol as medical devices, unless an exemption applies, we would be required to obtain either prior 510(k) clearance or prior pre-market approval from the FDAbefore commercializing the product. The FDA classifies medical devices into one of three classes. Devices deemed to pose lower risk to the patient are placed ineither class I or II, which, unless an exemption applies, requires the manufacturer to submit a pre-market notification requesting FDA clearance for commercialdistribution pursuant to Section 510(k) of the FFDCA. This process, known as 510(k) clearance, requires that the manufacturer demonstrate that the device issubstantially equivalent to a previously cleared and legally marketed 510(k) device or a “pre-amendment” class III device for which pre-market approvalapplications, or PMAs, have not been required by the FDA. This FDA review process typically takes from four to twelve months, although it can take longer. Mostclass I devices are exempted from this 510(k) premarket submission requirement. Devices deemed by the FDA to pose the greatest risk, such as life-sustaining,life-supporting, or implantable devices, or those deemed not substantially equivalent to a legally marketed predicate device, are placed in class III. Class III devicestypically require PMA approval. To obtain PMA approval, an applicant must demonstrate the reasonable safety and effectiveness of the device based, in part, ondata obtained in clinical studies. PMA reviews generally last between one and two years, although they can take longer. Both the 510(k) and the PMA processescan be expensive and lengthy and may not result in clearance or approval. If we are required to submit our products for pre-market review by the FDA, we may berequired to delay marketing while we obtain premarket clearance or approval from the FDA. There would be no assurance that we could ever obtain such clearanceor approval.In some cases, our customers may use our RUO products in their own laboratory-developed tests, or LDTs, or in other FDA-regulated products for clinicaldiagnostic use. The FDA has historically exercised enforcement discretion in not enforcing the medical device regulations against LDTs and LDT manufacturers.However, on October 3, 2014, the FDA issued two draft guidance documents that set forth the FDA’s proposed risk-based framework for regulating LDTs, whichare designed, manufactured, and used within a single laboratory. In January 2017, the FDA announced that it would not issue final guidance on the oversight ofLDTs and LDT manufacturers, but would seek further public discussion on an appropriate oversight approach and give Congress an opportunity to develop alegislative solution. Any future legislative or administrative rule making or oversight of LDTs and LDT manufacturers if and when finalized, may impact the salesof our products and how customers use our products, and may require us to change our business model in order to maintain compliance with these laws.We would become subject to additional FDA requirements if our products are determined to be medical devices or if we elect to seek 510(k) clearance orprior pre-market approval. We would need to continue to invest significant time and other resources to ensure ongoing compliance with FDA quality systemregulations and other post-market regulatory requirements. For additional information, please see the section entitled “Risk factors” in Part I, Item 1A of this Form10-K.International sales of medical devices are subject to foreign government regulations, which vary substantially from country to country. Outside of the EU,regulatory approval needs to be sought on a country-by-country basis in order to market medical devices. Although there is a trend towards harmonization ofquality system, standards and regulations in each country may vary substantially which can affect timelines of introduction.Environmental MattersWe are subject to many federal, state, local, and foreign environmental regulations. To comply with applicable regulations, we have and will continue toincur significant expense and allocate valuable internal resources to manage compliance-related issues. In addition, such regulations could restrict our ability toexpand or equip our facilities, or could require us to acquire costly equipment or to incur other significant expenses to comply with the regulations. For example,the Restriction on the Use of Certain Hazardous Substances in Electrical and Electronic Equipment Directive, or RoHS, and the Waste Electrical and ElectronicEquipment Directive, or WEEE, enacted in the European Union, regulate the use of certain hazardous substances in, and require the collection, reuse, and recyclingof waste from, products we manufacture. Certain of our products sold in these countries are subject to RoHS and WEEE requirements. If we fail to comply withany present and future regulations, we could be subject to future fines, penalties, and restrictions, such as the suspension of manufacturing of our products or aprohibition on the sale of products we manufacture. For additional information, please see the section entitled “Risk factors” in Part I, Item 1A of this Form 10-K.Additionally, our research and development and manufacturing processes involve the controlled use of hazardous materials, including flammables, toxics,corrosives, and biologics. Our research and manufacturing operations produce hazardous biological and chemical waste products. We seek to comply withapplicable laws regarding the handling and disposal of such materials. The volume of such materials used or generated at our facilities is small. However, wecannot eliminate the risk of accidental contamination or discharge and any resultant injury from these materials. We do not12currently maintain separate environmental liability coverage and any such contamination or discharge could result in significant cost to us in penalties, damages,and suspension of our operations.Geographic Area InformationDuring the last three years, a majority of our revenue was generated within the United States and Europe and a majority of our long-lived assets were locatedwithin the United States, in Singapore and in Canada. Total revenue received from customers outside the United States totaled $51.8 million , or 49% of our totalrevenue, in 2016, compared to $59.3 million , or 52% of our total revenue, in 2015, and $56.8 million , or 49% of our total revenue, in 2014. Please see Note 12 toour audited consolidated financial statements for additional information regarding geographic areas.SeasonalityIn 2011, 2012, 2014 and 2015, our product revenue was higher in the fourth quarter of the year than in the first quarter of the next year reflecting numerousfactors, including, among others, seasonal variations in customer operations and customer budget and capital spending cycles. Although this was not the case in thefourth quarter of 2013 compared to the first quarter of 2014, this historical trend continued in 2014 and 2015 with a decrease in revenue in the first quarters of 2015and 2016, respectively.Raw MaterialsCertain raw materials used in our Delta Gene and SNP Type assays and Access Array target-specific primers are available from a limited number of sources.Additionally, certain metals used in our Maxpar reagents are available from a sole source. Currently, we do not have supply agreements with these suppliers. Whilewe generally attempt to keep our inventory at minimal levels, we purchase incremental inventory as circumstances warrant to protect our supply chain.EmployeesAs of December 31, 2016 , we had 589 employees, of which 131 work in research and development, 97 work in general and administrative, 163 work inmanufacturing, and 198 work in sales, technical support, and marketing. None of our employees are represented by a labor union nor are they subject to acollective bargaining agreement.Corporate and Available InformationWe were incorporated in California in May 1999 as Mycometrix Corporation, changed our name to Fluidigm Corporation in April 2001, and reincorporatedin Delaware in July 2007. Our principal executive offices are located at 7000 Shoreline Court, Suite 100, South San Francisco, California 94080. Our telephonenumber is (650) 266-6000. Our website address is www.fluidigm.com. We make available on our website, free of charge, our Annual Report on Form 10-K,Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and any amendments to those reports, as soon as reasonably practicable after we electronically filesuch material with, or furnish it to, the Securities and Exchange Commission, or SEC. Our SEC reports can be accessed through the investor relations page of ourwebsite located at http://investors.fluidigm.com/sec.cfm. Additionally, a copy of this Annual Report on Form 10-K is located at the SEC’s Public Reference Roomat 100 F Street, NE, Washington, D.C. 20549. Information on the operation of the Public Reference Room can be obtained by calling the SEC at 1-800-SEC-0330.We webcast our earnings calls and certain events we participate in or host with members of the investment community on our investor relations page of ourwebsite. Corporate governance information, including our board committee charters, code of ethics, and corporate governance principles, is also available on ourinvestor relations page of our website located at http://investors.fluidigm.com/corporate-governance.cfm.In addition to SEC filings, press releases, public conference calls, and webcasts, we use our website (www.fluidigm.com), corporate Twitter account(@Fluidigm), Facebook page (https://www.facebook.com/Fluidigm), and LinkedIn page (https://www.linkedin.com/company/fluidigm-corporation) as channels ofdistribution of information about our company, our products, our planned financial and other announcements, our attendance at upcoming investor and industryconferences, and other matters. It is possible that the information we post on our website and through these social media accounts could be deemed materialinformation. We may use these channels to comply with our disclosure obligations under Regulation FD. Therefore, investors should monitor our website and oursocial media accounts in addition to following our press releases, SEC filings, public conference calls, and webcasts. 13The contents of our website and the information we post through social media are not a part of, and are not incorporated by reference into, this AnnualReport on Form 10-K or any other report or document we file with the SEC. Any references to our websites are intended to be inactive textual references only.Executive OfficersThe following table sets forth the names, ages (as of February 10, 2017) and positions of our executive officers: Name Age PositionStephen Christopher Linthwaite 45 President, Chief Executive Officer, and DirectorVikram Jog 60 Chief Financial OfficerSteven C. McPhail 62 Chief Commercial OfficerNicholas Khadder 43 Senior Vice President, General Counsel, Chief Compliance Officer and SecretaryMai Chan (Grace) Yow 58 Executive Vice President, Worldwide Manufacturing and Managing Director of FluidigmSingapore Pte. Ltd.Jennifer Lee 53 Vice President, Controller, and Principal Accounting OfficerStephen Christopher Linthwaite joined Fluidigm as President and Chief Operating Officer in August 2016 and has served as our President, Chief ExecutiveOfficer, and Director since October 2016. From August 2003 to April 2016, Mr. Linthwaite held various managerial positions at Thermo Fisher Scientific Inc., alife sciences company, and prior to its acquisition by Thermo Fisher, at Life Technologies Corporation, a life sciences company, including President, GeneticSciences Division, from December 2014 to April 2016, President, Genetic Analysis Platform, from September 2011 to December 2014, and various othermanagerial positions at Invitrogen prior to the creation of Life Technologies through a merger of Invitrogen and Applied Biosystems. Prior to joining Invitrogen,Mr. Linthwaite held various strategic consulting roles. Mr. Linthwaite served on the board of directors of Claritas Genomics, Inc. from December 2014 to April2016. Mr. Linthwaite received a M.B.A. from the University of Virginia (Darden) School of Business, and a B.A. in Foreign Affairs from the University ofVirginia. Prior to business school, Mr. Linthwaite served on active duty in the U.S. Army as an armor officer. We believe that Mr. Linthwaite's extensive industryexperience with life sciences companies qualifies him to serve on our board.Vikram Jog has served as our Chief Financial Officer since February 2008. From April 2005 to February 2008, Mr. Jog served as Chief Financial Officer forXDx, Inc. (now CareDx, Inc.), a molecular diagnostics company. From March 2003 to April 2005, Mr. Jog was a Vice President of Applera Corporation, a lifescience company that is now part of Thermo Fisher Scientific, and Vice President of Finance for its related businesses, Celera Genomics and Celera Diagnostics.From April 2001 to March 2003, Mr. Jog was Vice President of Finance for Celera Diagnostics and Corporate Controller of Applera Corporation. Mr. Jog receiveda Bachelor of Commerce degree from Delhi University and an M.B.A. from Temple University. Mr. Jog is a member of the American Institute of Certified PublicAccountants.Steven C. McPhail joined Fluidigm as General Manager, Production Genomics in May 2015 and became our Chief Commercial Officer in August 2016.From December 2014 to March 2015, Mr. McPhail was vice president, special projects at Quintiles Transnational Corporation, a biopharmaceutical developmentand commercial outsourcing services firm. From February 2003 to August 2012, Mr. McPhail was President and Chief Executive Officer of Expression Analysis,Inc., a genomic services company that was acquired by Quintiles Transnational Corporation in August 2012, where Mr. McPhail was President of the post-acquisition operation until December 2014. Prior to Expression Analysis, Inc., Mr. McPhail held various staff and management positions at companies in thediagnostic, biotechnology, and medical device markets, including ArgoMed Inc., Xanthon, Inc., TriPath Imaging Inc., Dynex Technologies, Inc., and AbbottLaboratories. Mr. McPhail serves on the Board of Visitors of NC Children's Hospital and on the Board of Trustees of the Carolinas chapter of the Crohn's andColitis Foundation of America as well as ImproveCareNow, a quality improvement network designed to improve the care and outcomes of children withinflammatory bowel disease. Mr. McPhail received a B.S. in Biology from San Diego State University.Nicholas Khadder has served as our Senior Vice President, General Counsel, Chief Compliance Officer and Corporate Secretary since June 2016. From 2010to June 2016, Mr. Khadder held various positions at Amyris, Inc., an industrial biotechnology company, including senior vice president, general counsel andcorporate secretary from 2013 to June 2016, interim general counsel from July 2013 to December 2013 and assistant general counsel from October 2010 to July2013. Prior to joining Amyris, Mr. Khadder served in senior corporate counsel roles at LeapFrog Enterprises, Inc., an educational entertainment company, fromAugust 2008 to September 2010, and at Protiviti, Inc., an internal audit and risk consulting14firm, from June 2005 to July 2008. Before commencing his in-house legal career, Mr. Khadder was a corporate law associate at Fenwick & West LLP from 1998to 2005. Mr. Khadder received a J.D. from Berkeley Law (the University of California, Berkeley, School of Law) and a B.A. in English from the University ofCalifornia, Berkeley.Mai Chan (Grace) Yow has served as Executive Vice President, Worldwide Manufacturing of Fluidigm Singapore Pte. Ltd., our Singapore subsidiary, sinceFebruary 2012, and as Managing Director of Fluidigm Singapore Pte. Ltd. since March 2006. Ms. Yow served as Vice President, Worldwide Manufacturing, fromMarch 2006 to January 2012. From June 2005 to March 2006, Ms. Yow served as General Manager of Fluidigm Singapore Pte. Ltd. From August 2004 to May2005, Ms. Yow served as Vice President Engineering (Asia) for Kulicke and Soffa, a public semiconductor equipment manufacturer. From March 1991 to July2004, Ms. Yow served as Director, Assembly Operations, Plant Facilities and EHS, for National Semiconductor Singapore, a semiconductor fabrication subsidiaryof National Semiconductor Corporation. Ms. Yow received a B.E. in Electronic Engineering from Curtin University, a Certificate in Management Studies from theSingapore Institute of Management, and a Diploma in Electrical Engineering from Singapore Polytechnic.Jennifer Lee has served as Vice President, Controller, and Principal Accounting Officer since May 2016. From 1996 to May 2016, Ms. Lee held variousfinance leadership roles at Genentech, Inc., a biotechnology company that was acquired by Roche Holdings, Inc., in March 2009, including Director ofCommercial Finance from 2010 to May 2016, Director of General Audit from 2008 to 2009, Director of Collaborations Finance and Royalties from 2006 to 2008and Associate Director of External Reporting from 2000 to 2006. Prior to joining Genentech, Ms. Lee held staff and managerial roles at Pacific Gas and ElectricCompany and Arthur Andersen & Co. Ms. Lee received her B.S. in accounting from San Francisco State University and her M.B.A. from Golden Gate University.Ms. Lee is also a certified public accountant.ITEM 1A. RISK FACTORSWe operate in a rapidly changing environment that involves numerous uncertainties and risks. The following risks and uncertainties may have a materialand adverse effect on our business, financial condition, or results of operations. You should consider these risks and uncertainties carefully, together with all of theother information included or incorporated by reference in this Form 10-K. If any of the risks or uncertainties we face were to occur, the trading price of oursecurities could decline, and you may lose all or part of your investment.Risks Related to Fluidigm’s Business and StrategyOur financial results and revenue growth rates have varied significantly from quarter-to-quarter and year-to-year due to a number of factors, and asignificant variance in our operating results or rates of growth, if any, could lead to substantial volatility in our stock price.Our revenue, results of operations, and revenue growth rates have varied in the past and may continue to vary significantly from quarter-to-quarter or year-to-year. For example, in 2011, 2012, 2014 and 2015, we experienced higher sales in the fourth quarter than in the first quarter of the next fiscal year. Although thiswas not the case in the fourth quarter of 2013 compared to the first quarter of 2014, this seasonal historical trend continued in 2014 and 2015 with a decrease inrevenue in the first quarters of 2015 and 2016, respectively. Additionally, for the quarters ended March 31, 2015 and June 30, 2015, we experienced year-over-yearrevenue growth rates that were substantially lower than revenue growth rates experienced in other periods since our initial public offering, and we experienced ayear-over-year decline in revenue for the quarters ended September 30, 2016, June 30, 2016, September 30, 2015, and for the years ended December 31, 2016 and2015. We may experience substantial variability in our product mix from period-to-period as revenue from sales of our instruments relative to sales of ourconsumables may fluctuate or deviate significantly from expectations. Variability in our quarterly or annual results of operations, mix of product revenue, or ratesof revenue growth, if any, may lead to volatility in our stock price as research analysts and investors respond to these fluctuations. These fluctuations are due tonumerous factors that are difficult to forecast, including: fluctuations in demand for our products; changes in customer budget cycles and capital spending; seasonalvariations in customer operations; tendencies among some customers to defer purchase decisions to the end of the quarter; the large unit value of our systems;changes in our pricing and sales policies or the pricing and sales policies of our competitors; our ability to design, manufacture, market, sell, and deliver productsto our customers in a timely and cost-effective manner; quality control or yield problems in our manufacturing operations; our ability to timely obtain adequatequantities of the materials or components used in our products, which in certain cases are purchased through sole and single source suppliers; new productintroductions and enhancements by us and our competitors; unanticipated increases in costs or expenses; our complex, variable and, at times, lengthy sales cycle;global economic conditions; and fluctuations in foreign currency exchange rates. Additionally, we have certain customers who have historically placed large ordersin multiple quarters during a calendar year. A significant reduction in orders from one or more of these customers could adversely affect our revenue and operatingresults,15and if these customers defer or cancel purchases or otherwise alter their purchasing patterns, our financial results and actual results of operations could besignificantly impacted. Other unknown or unpredictable factors also could harm our results.The foregoing factors, as well as other factors, could materially and adversely affect our quarterly and annual results of operations and rates of revenuegrowth, if any. We have experienced significant revenue growth in the past but we may not achieve similar growth rates in future periods. You should not rely onour operating results for any prior quarterly or annual period as an indication of our future operating performance. If we are unable to maintain adequate revenuegrowth, our operating results could suffer and our stock price could decline. In addition, a significant amount of our operating expenses are relatively fixed due toour manufacturing, research and development, and sales and general administrative efforts. Any failure to adjust spending quickly enough to compensate for ashortfall relative to our anticipated revenue could magnify the adverse impact of such shortfalls on our results of operations. We expect that our sales will continueto fluctuate on an annual and quarterly basis and that our financial results for some periods may be below those projected by securities analysts, which couldsignificantly decrease the price of our common stock.The life science research and applied markets are highly competitive and subject to rapid technological change, and we may not be able to successfullycompete.The markets for our products are characterized by rapidly changing technology, evolving industry standards, changes in customer needs, emergingcompetition, new product introductions, and strong price competition. We compete with both established and development stage life science research companiesthat design, manufacture, and market instruments and consumables for gene expression analysis, single-cell targeted gene expression or protein expressionanalysis, single nucleotide polymorphism genotyping, or SNP genotyping, polymerase chain reaction, or PCR, digital PCR, other nucleic acid detection, flowcytometry, cell imaging, and additional applications using well established laboratory techniques, as well as newer technologies such as bead encoded arrays,microfluidics, nanotechnology, high-throughput DNA sequencing, microdroplets, and photolithographic arrays. Most of our current competitors have significantlygreater name recognition, greater financial and human resources, broader product lines and product packages, larger sales forces, larger existing installed bases,larger intellectual property portfolios, and greater experience and scale in research and development, manufacturing, and marketing than we do. For example,companies such as 10X Genomics, Inc., Affymetrix, Inc., Agena Bioscience, Inc., Agilent Technologies, Inc., Becton, Dickinson and Company, Bio-RadLaboratories, Inc., Cellular Research, Inc. (now a part of Becton, Dickinson and Company), Danaher Corporation, Illumina, Inc., Life Technologies Corporation(now part of Thermo Fisher Scientific Inc.), LGC Limited, Luminex Corporation, Millipore Corporation, NanoString Technologies, Inc., PerkinElmer, Inc.(through its acquisition of Caliper Life Sciences, Inc.), RainDance Technologies, Inc. (acquisition by Bio-Rad Laboratories, Inc. pending), Roche DiagnosticsCorporation, Sony Corporation, Thermo Fisher Scientific Inc., and WaferGen Bio-systems, Inc. have products that compete in certain segments of the market inwhich we sell our products. In addition, we have recently experienced increased competition in the single-cell genomics market, including new product releasesfrom 10X Genomics, Inc. and WaferGen Bio-systems, Inc., as well as the acquisition of Cellular Research by Becton Dickinson and Company and an announcedexclusive partnership between Illumina, Inc. and Bio-Rad Laboratories, Inc. In addition due to the release of our Imaging Mass Cytometry system, we now areexposed to competition from companies offering imaging-based systems, specialized reagents and/or services including Carl Zeiss Inc., Leica Biosystems, NikonCorporation, Olympus America Inc., Roche Diagnostics Corporation, PerkinElmer, Inc. Agilent Technologies, Inc. and Neogenomics (Multiomyx).Competitors may be able to respond more quickly and effectively than we can to new or changing opportunities, technologies, standards, or customerrequirements. In light of these advantages, even if our technology is more effective than the product or service offerings of our competitors, current or potentialcustomers might accept competitive products and services in lieu of purchasing our technology. We anticipate that we will face increased competition in the futureas existing companies and competitors develop new or improved products and as new companies enter the market with new technologies. Increased competition islikely to result in pricing pressures, which could reduce our profit margins and increase our sales and marketing expenses. In addition, mergers, consolidations, orother strategic transactions between two or more of our competitors, or between our competitor and one of our key customers, could change the competitivelandscape and weaken our competitive position, adversely affecting our business.Market opportunities may not develop as quickly as we expect, limiting our ability to successfully sell our products, or our product development andstrategic plans may change and our entry into certain markets may be delayed, if it occurs at all.The application of our technologies to high-throughput genomics, single-cell genomics and mass cytometry applications are emerging market opportunities.We believe these opportunities will take several years to develop or mature and we cannot be certain that these market opportunities will develop as we expect. Thefuture growth of our markets and the success of our products depend on many factors beyond our control, including recognition and acceptance by the scientificcommunity, and16the growth, prevalence, and costs of competing methods of genetic and protein analysis. If the market for single-cell genomics and production genomics do notdevelop as we expect, our business may be adversely affected. Additionally, our success in these markets may depend to a large extent on our ability tosuccessfully sell products using our technologies. If we are not able to successfully market and sell our products, or to achieve the revenue or margins we expect,our operating results may be harmed and we may not recover our product development and marketing expenditures. In addition, our product development andstrategic plans may change, which could delay or impede our entry into these markets.If our products fail to achieve and sustain sufficient market acceptance, our revenue will be adversely affected.Our success depends, in part, on our ability to develop and market products that are recognized and accepted as reliable, enabling and cost-effective. Most ofour potential customers already use expensive research systems in their laboratories and may be reluctant to replace those systems. Market acceptance of oursystems will depend on many factors, including our ability to convince potential customers that our systems are an attractive alternative to existing technologies.Compared to some competing technologies, our technology is relatively new, and most potential customers have limited knowledge of, or experience with, ourproducts. Prior to adopting our systems, some potential customers may need to devote time and effort to testing and validating our systems. Any failure of oursystems to meet these customer benchmarks could result in customers choosing to retain their existing systems or to purchase systems other than ours.In addition, it is important that our systems be perceived as accurate and reliable by the scientific and medical research community as a whole. Historically, asignificant part of our sales and marketing efforts has been directed at convincing industry leaders of the advantages of our systems and encouraging such leadersto publish or present the results of their evaluation of our system. If we are unable to continue to induce leading researchers to use our systems, or if suchresearchers are unable to achieve and publish or present significant experimental results using our systems, acceptance and adoption of our systems will be slowedand our ability to increase our revenue would be adversely affected.We may experience development or manufacturing problems or delays that could limit the growth of our revenue or increase our losses.We may encounter unforeseen situations in the manufacturing and assembly of our products that would result in delays or shortfalls in our production. Forexample, our production processes and assembly methods may have to change to accommodate any significant future expansion of our manufacturing capacity,which may increase our manufacturing costs, delay production of our products, reduce our product margin, and adversely impact our business.Additionally, all of our IFCs for commercial sale are manufactured at our facility in Singapore. Production of the elastomeric block that is at the core of ourIFCs is a complex process requiring advanced clean rooms, sophisticated equipment, and strict adherence to procedures. Any contamination of the clean room,equipment malfunction, or failure to strictly follow procedures can significantly reduce our yield in one or more batches. We have in the past experiencedvariations in yields due to such factors. A drop in yield can increase our cost to manufacture our IFCs or, in more severe cases, require us to halt the manufacture ofour IFCs until the problem is resolved. Identifying and resolving the cause of a drop in yield can require substantial time and resources.Furthermore, developing an IFC for a new application may require developing a specific production process for that type of IFC. While all of our IFCs areproduced using the same basic processes, significant variations may be required to ensure adequate yield of any particular type of IFC. Developing such a processcan be very time consuming, and any unexpected difficulty in doing so can delay the introduction of a product.If our manufacturing activities are adversely impacted, or if we are otherwise unable to keep up with demand for our products by successfully manufacturing,assembling, testing, and shipping our products in a timely manner, our revenue could be impaired, market acceptance for our products could be adversely affectedand our customers might instead purchase our competitors’ products.If our research and product development efforts do not result in commercially viable products within anticipated timelines, if at all, our business andresults of operations will be adversely affected.Our business is dependent on the improvement of our existing products, our development of new products to serve existing markets, and our development ofnew products to create new markets and applications that were previously not practical with existing systems. We intend to devote significant personnel andfinancial resources to research and development activities designed to advance the capabilities of our technology. We have developed design rules for theimplementation of our technology that are frequently revised to reflect new insights we have gained about the technology. In addition, we have17discovered that biological or chemical reactions sometimes behave differently when implemented on our systems rather than in a standard laboratory environment.Furthermore, many such reactions take place within the confines of single cells, which have also demonstrated unexpected behavior when grown and manipulatedwithin microfluidic environments. As a result, research and development efforts may be required to transfer certain reactions and cell handling techniques to oursystems. In the past, product development projects have been significantly delayed when we encountered unanticipated difficulties in implementing a process onour systems. We may have similar delays in the future, and we may not obtain any benefits from our research and development activities. Any delay or failure byus to develop and release new products or product enhancements would have a substantial adverse effect on our business and results of operations.Our products could have defects or errors, which may give rise to claims against us, adversely affect market adoption of our systems, and adversely affectour business, financial condition, and results of operations.Our systems utilize novel and complex technology and such systems may develop or contain undetected defects or errors. We cannot assure you that materialperformance problems, defects, or errors will not arise, and as we increase the density and integration of our systems, these risks may increase. We generallyprovide warranties that our systems will meet performance expectations and will be free from defects. The costs incurred in correcting any defects or errors may besubstantial and could adversely affect our operating margins. For example, we have experienced a performance issue with respect to certain IFCs used in our C1systems due to the presence of more than one cell in an IFC chamber. Although we have redesigned such C1 IFCs, we may experience additional unexpectedproduct defects or errors that could affect our ability to adequately address these performance issues.In manufacturing our products, including our systems, IFCs, and assays, we depend upon third parties for the supply of various components, many of whichrequire a significant degree of technical expertise to produce. In addition, we purchase certain products from third-party suppliers for resale. If our suppliers fail toproduce components to specification or provide defective products to us for resale and our quality control tests and procedures fail to detect such errors or defects,or if we or our suppliers use defective materials or workmanship in the manufacturing process, the reliability and performance of our products will becompromised.If our products contain defects, we may experience:•a failure to achieve market acceptance or expansion of our product sales;•loss of customer orders and delay in order fulfillment;•damage to our brand reputation;•increased cost of our warranty program due to product repair or replacement;•product recalls or replacements;•inability to attract new customers;•diversion of resources from our manufacturing and research and development departments into our service department; and•legal claims against us, including product liability claims, which could be costly and time consuming to defend and result in substantial damages.In addition, certain of our products are marketed for use with products sold by third parties. For example, our Access Array system is marketed as compatiblewith major next-generation DNA sequencing instruments. If such third-party products are not produced to specification, are produced in accordance with modifiedspecifications, or are defective, they may not be compatible with our products. In such case, the reliability and performance of our products may be compromised.The occurrence of any one or more of the foregoing could negatively affect our business, financial condition, and results of operations.18Our business depends on research and development spending levels of academic, clinical, and governmental research institutions, and biopharmaceutical,biotechnology, Ag-Bio companies and CRO's, a reduction in which could limit our ability to sell our products and adversely affect our business.We expect that our revenue in the foreseeable future will be derived primarily from sales of our systems and IFCs to academic institutions, clinical researchlaboratories that use our technology to develop tests, and biopharmaceutical, biotechnology, Ag-Bio companies and CRO's worldwide. Our success will dependupon their demand for and use of our products. Accordingly, the spending policies of these customers could have a significant effect on the demand for ourtechnology. These policies may be based on a wide variety of factors, including concerns regarding any future federal government budget sequestrations, theavailability of resources to make purchases, the spending priorities among various types of equipment, policies regarding spending during recessionary periods,and changes in the political climate. In addition, academic, governmental, and other research institutions that fund research and development activities may besubject to stringent budgetary constraints that could result in spending reductions, reduced allocations, or budget cutbacks, which could jeopardize the ability ofthese customers to purchase our products. Our operating results may fluctuate substantially due to reductions and delays in research and development expendituresby these customers. For example, reductions in capital and operating expenditures by these customers may result in lower than expected sales of our systems andIFCs. These reductions and delays may result from factors that are not within our control, such as:•changes in economic conditions;•natural disasters;•changes in government programs that provide funding to research institutions and companies;•changes in the regulatory environment affecting life science and Ag-Bio companies engaged in research and commercial activities;•differences in budget cycles across various geographies and industries;•market-driven pressures on companies to consolidate operations and reduce costs;•mergers and acquisitions in the life science and Ag-Bio industries; and•other factors affecting research and development spending.Any decrease in our customers’ budgets or expenditures, or in the size, scope, or frequency of capital or operating expenditures, could materially andadversely affect our operations or financial condition.If one or more of our manufacturing facilities become unavailable or inoperable, we will be unable to continue manufacturing our instruments, IFCs,assays and/or reagents and, as a result, our business will be harmed until we are able to secure a new facility.We manufacture all of our genomics analytical and preparatory instruments and integrated fluidic circuits, or IFCs, for commercial sale at our facility inSingapore, our mass cytometry instruments for commercial sale at our facility in Canada, and our assays and reagents for commercial sale at our facility in theUnited States. No other manufacturing facilities are currently available to us, particularly facilities of the size and scope required by our Singapore and Canadaoperations. Our facilities and the equipment we use to manufacture our instruments, IFCs, assays, and reagents would be costly to replace and could requiresubstantial lead time to repair or replace. Our facilities may be harmed or rendered inoperable by natural or man-made disasters, which may render it difficult orimpossible for us to manufacture our products for some period of time. If any of our facilities become unavailable to us, we cannot provide assurances that we willbe able to secure a new manufacturing facility on acceptable terms, if at all. The inability to manufacture our products, combined with our limited inventory ofmanufactured supplies, may result in the loss of customers or harm our reputation, and we may be unable to reestablish relationships with those customers in thefuture. Although we possess insurance for damage to our property and the disruption of our business, this insurance may not be sufficient to cover all of ourpotential losses and may not continue to be available to us on acceptable terms, or at all. If our manufacturing capabilities are impaired, we may not be able tomanufacture and ship our products in a timely manner, which would adversely impact our business.19We generate a substantial portion of our revenue internationally and are subject to various risks relating to such international activities, which couldadversely affect our sales and operating performance. In addition, any disruption or delay in the shipping or off-loading of our products, whetherdomestically or internationally, may have an adverse effect on our financial condition and results of operations.During the years 2016 , 2015 , and 2014 , approximately 49% , 52%, and 49%, respectively, of our product and service revenue was generated from sales tocustomers located outside of the United States. We believe that a significant percentage of our future revenue will come from international sources as we expandour international operations and develop opportunities in other countries. Engaging in international business inherently involves a number of difficulties and risks,including:•required compliance with existing and changing foreign regulatory requirements and laws that are or may be applicable to our business in the future,such as the RoHS and WEEE directives, which regulate the use of certain hazardous substances in, and require the collection, reuse, and recycling ofwaste from, products we manufacture;•required compliance with anti-bribery laws, such as the U.S. Foreign Corrupt Practices Act and U.K. Bribery Act, data privacy requirements, laborlaws, and anti-competition regulations;•export or import restrictions;•laws and business practices favoring local companies;•longer payment cycles and difficulties in enforcing agreements and collecting receivables through certain foreign legal systems;•unstable economic, political, and regulatory conditions;•potentially adverse tax consequences, tariffs, customs charges, bureaucratic requirements, and other trade barriers;•difficulties and costs of staffing and managing foreign operations; and•difficulties protecting or procuring intellectual property rights.If one or more of these risks occurs, it could require us to dedicate significant resources to remedy, and if we are unsuccessful in finding a solution, ourfinancial results will suffer.In addition, on June 23, 2016, the United Kingdom (U.K.) held a referendum in which voters approved an exit from the European Union, commonly referredto as “Brexit.” As a result of the referendum, it is expected that the British government will begin negotiating the terms of the U.K.’s withdrawal from theEuropean Union and the U.K.’s future relationships with European Union member states. Adverse consequences concerning Brexit or the European Union couldinclude deterioration in global economic conditions, instability in global financial markets, political uncertainty, volatility in currency exchange rates, or adversechanges in the cross-border agreements currently in place, any of which could have an adverse impact on our financial results in the future.A majority of our product sales are currently denominated in U.S. dollars and fluctuations in the value of the U.S. dollar relative to foreign currencies coulddecrease demand for our products and adversely impact our financial performance. For example, if the value of the U.S. dollar increases relative to foreigncurrencies, our products could become more costly to the international consumer and therefore less competitive in international markets, or if the value of the U.S.dollar decreases relative to the Singapore dollar or the Canadian dollar, it would become more costly in U.S. dollars for us to manufacture our products inSingapore and/or in Canada. Additionally, our expenses are generally denominated in the currencies of the countries in which our operations are located, which isprimarily in the United States, with a portion of expenses incurred in Singapore and Canada where a significant portion of our manufacturing operations arelocated. Our results of operations and cash flows are, therefore, subject to fluctuations due to changes in foreign currency exchange rates. The volatility ofexchange rates depends on many factors that we cannot forecast with reliable accuracy. We have experienced and will continue to experience fluctuations in ournet income or loss as a result of transaction gains or losses related to revaluing certain current asset and current liability balances that are denominated in currenciesother than the functional currency of the entities in which they are recorded. For example, for the years ended December 31, 2016, 2015, and 2014, we experiencedforeign currency losses of $1.5 million , $1.6 million, and $1.1 million, respectively. Fluctuations in currency exchange rates could have an adverse impact on ourfinancial results in the future.20We rely on shipping providers to deliver products to our customers globally. Labor, tariff, or World Trade Organization-related disputes, piracy, physicaldamage to shipping facilities or equipment caused by severe weather or terrorist incidents, congestion at shipping facilities, inadequate equipment to load, dock,and offload our products, energy-related tie-ups, or other factors could disrupt or delay shipping or off-loading of our products domestically and internationally.Such disruptions or delays may have an adverse effect on our financial condition and results of operations.We are dependent on single and sole source suppliers for some of the components and materials used in our products, and the loss of any of thesesuppliers could harm our business.We rely on single and sole source suppliers for certain components and materials used in our products. Additionally, several of our instruments areassembled at the facilities of contract manufacturers in Singapore. We do not have long term contracts with our suppliers of these components and materials or ourassembly service providers. The loss of a single or sole source supplier of any of the following components and/or materials would require significant time andeffort to locate and qualify an alternative source of supply, if at all:•The IFCs used in our microfluidic systems are fabricated using a specialized polymer, and other specialized materials, that are available from a limitednumber of sources. In the past, we have encountered quality issues that have reduced our manufacturing yield or required the use of additionalmanufacturing processes.•Specialized pneumatic and electronic components for our C1, Callisto, Juno, and Polaris systems are available from a limited number of sources.•The electron multiplier detector included in the Helios/CyTOF 2 systems and certain metal isotopes used with the Helios/CyTOF 2 systems arepurchased from sole source suppliers.•The movement stage included in the Imaging Mass Cytometer is purchased from a sole source supplier.•The nickel sampler cone used with the Helios/CyTOF 2 systems is purchased from single source suppliers and is available from a limited number ofsources.•The raw materials for our Delta Gene and SNP Type assays and Access Array target-specific primers are available from a limited number of sources.Our reliance on single and sole source suppliers and assembly service providers also subjects us to other risks that could harm our business, including thefollowing:•we may be subject to increased component or assembly costs;•we may not be able to obtain adequate supply or services in a timely manner or on commercially reasonable terms;•our suppliers or service providers may make errors in manufacturing or assembly of components that could negatively affect the efficacy of our productsor cause delays in shipment of our products; and•our suppliers or service providers may encounter capacity constraints or financial hardships unrelated to our demand for components or services, whichcould inhibit their ability to fulfill our orders and meet our requirements.We have in the past experienced quality control and supply problems with some of our suppliers, such as manufacturing errors, and may again experienceproblems in the future. We may not be able to quickly establish additional or replacement suppliers, particularly for our single source components, or assemblyservice providers. Any interruption or delay in the supply of components or materials or assembly of our instruments, or our inability to obtain components,materials, or assembly services from alternate sources at acceptable prices in a timely manner, could impair our ability to meet the demand of our customers andcause them to cancel orders or switch to competitive products.Our future success is dependent upon our ability to expand our customer base and introduce new applications.Our customer base is primarily composed of academic institutions, clinical research laboratories that use our technology to develop tests, andbiopharmaceutical, biotechnology, and agricultural biotechnology, or Ag-Bio, companies that perform analyses for research and commercial purposes. Our successwill depend, in part, upon our ability to increase our market share among these customers, attract additional customers outside of these markets, and market newapplications to existing and new21customers as we develop such applications. Attracting new customers and introducing new applications require substantial time and expense. For example, it maybe difficult to identify, engage, and market to customers who are unfamiliar with the current applications of our systems. Any failure to expand our existingcustomer base or launch new applications would adversely affect our ability to increase our revenue.We may not be able to develop new products or enhance the capabilities of our existing systems to keep pace with rapidly changing technology andcustomer requirements, which could have a material adverse effect on our business, revenue, financial condition, and operating results.Our success depends on our ability to develop new products and applications for our technology in existing and new markets, while improving theperformance and cost-effectiveness of our systems. New technologies, techniques, or products could emerge that might offer better combinations of price andperformance than our current or future product lines and systems. Existing markets for our products, including high-throughput genomics, single-cell genomics andmass cytometry, as well as potential markets for our products such as high-throughput DNA sequencing and molecular diagnostics applications, are characterizedby rapid technological change and innovation. It is critical to our success for us to anticipate changes in technology and customer requirements and to successfullyintroduce new, enhanced, and competitive technology to meet our customers’ and prospective customers’ needs on a timely and cost-effective basis. Developingand implementing new technologies will require us to incur substantial development costs and we may not have adequate resources available to be able tosuccessfully introduce new applications of, or enhancements to, our systems. We cannot guarantee that we will be able to maintain technological advantages overemerging technologies in the future. While we typically plan improvements to our systems, we may not be able to successfully implement these improvements. Ifwe fail to keep pace with emerging technologies, demand for our systems will not grow and may decline, and our business, revenue, financial condition, andoperating results could suffer materially. In addition, if we introduce enhanced systems but fail to manage product transitions effectively, customers may delay orforgo purchases of our systems and our operating results may be adversely affected by product obsolescence and excess inventory. Even if we successfullyimplement some or all of these planned improvements, we cannot guarantee that our current and potential customers will find our enhanced systems to be anattractive alternative to existing technologies, including our current products.We have incurred losses since inception, and we may continue to incur substantial losses for the foreseeable future.We have a limited operating history and have incurred significant losses in each fiscal year since our inception, including net losses of $76.0 million , $53.3million , and $52.8 million during the years 2016 , 2015 , and 2014 , respectively. As of December 31, 2016 , we had an accumulated deficit of $439.5 million .These losses have resulted principally from costs incurred in our research and development programs, and from our manufacturing costs and selling, general, andadministrative expenses. We believe that our continued investment in research and development, sales, and marketing is essential to our long-term competitiveposition and future growth. However, we recently implemented efficiency and cost-savings initiatives intended to stabilize our business operations and return togrowth. These initiatives have included targeted workforce reductions and optimizing our facilities and excess space. They may also include decreasing ordeferring capital expenditures and development activities. To the extent we are unable to invest sufficiently in these activities, it may impair our ability to develop,market and sell new and existing products. Until we are able to generate additional revenue to support our level of operating expenses, we will continue to incuroperating and net losses and negative cash flow from operations. Because of the numerous risks and uncertainties associated with our commercialization effortsand future product development, we are unable to predict when we will become profitable, and we may never become profitable. Even if we do achieveprofitability, we may not be able to sustain or increase our profitability.If we require additional funds in the future, we may not be able to obtain such funds on acceptable terms, or at all. If we raise funds by issuing equitysecurities, our stockholders may experience dilution. Debt financing, if available, may involve covenants restricting our operations or our ability to incur additionaldebt. Any additional debt or equity financing that we raise may contain terms that are not favorable to us or our stockholders. If we do not have, or are not able toobtain sufficient funds, we may have to delay development or commercialization of our products or license to third parties the rights to commercialize products ortechnologies that we would otherwise seek to commercialize. We may also have to reduce marketing, customer support, research and development or otherresources devoted to our products.Impairment of our goodwill or other intangible assets could materially and adversely affect our business, operating results, and financial condition.As of December 31, 2016 , we had approximately $190.6 million of goodwill and net intangible assets, including approximately $104.1 million of goodwilland $86.5 million of net intangible assets. These assets represent a significant portion of the assets recorded on our consolidated balance sheet and relate primarilyto our acquisition of DVS Sciences, Inc.,22or DVS, in February 2014. In addition, if in the future we acquire additional businesses, technologies, or other intangible assets, a substantial portion of the valueof such assets may be recorded as goodwill or intangible assets.The carrying amounts of goodwill and intangible assets are affected whenever events or changes in circumstances indicate that their carrying amounts maynot be recoverable. We review goodwill and indefinite lived intangible assets for impairment at least annually and more frequently under certain circumstances.Other intangible assets that are deemed to have finite useful lives will continue to be amortized over their useful lives but must be reviewed for impairment whenevents or changes in circumstances indicate that the carrying amount of these assets may not be recoverable. Events or changes in circumstances that could affectthe likelihood that we will be required to recognize an impairment charge include declines in our stock price or market capitalization, declines in our market shareor revenues, an increase in our losses, rapid changes in technology, failure to achieve the benefits of capacity increases and utilization, significant litigation arisingout of an acquisition, or other matters. In particular, these or other adverse events or changes in circumstances may affect the estimated undiscounted futureoperating cash flows expected to be derived from our goodwill and intangible assets. We have recently experienced substantial declines in our stock price, andcontinued weakness or further declines in our stock price increase the likelihood that we may be required to recognize impairment charges. Any impairmentcharges could have a material adverse effect on our operating results and net asset value in the quarter in which we recognize the impairment charge. We cannotprovide assurances that we will not in the future be required to recognize impairment charges. Our business operations are dependent upon our new senior management team and the ability of our other new employees to learn their new roles. If weare unable to recruit and retain key executives, scientists, and technical support personnel, we may be unable to achieve our goals.Our performance is substantially dependent on the performance of our senior management, which has substantially changed over the last year, including, forexample, the recent departures of our Chief Executive Officer, Gajus Worthington, and Executive Vice President, Research and Development and Marketing, MarcUnger. We have a new president and chief executive officer who started in August 2016, a new controller and principal accounting officer who started in May2016, a new general counsel who started in June 2016, and other new members of our senior management team. As new employees gain experience in their roles,we could experience inefficiencies or a lack of business continuity due to loss of historical knowledge and a lack of familiarity of new employees with businessprocesses, operating requirements, policies and procedures, and we may experience additional costs as new employees learn their roles and gain necessaryexperience. It is important to our success that these key employees quickly adapt to and excel in their new roles. If they are unable to do so, our business andfinancial results could be materially adversely affected. In addition, the loss of the services of any member of our senior management or our scientific or technicalsupport staff might significantly delay or prevent the development of our products or achievement of other business objectives by diverting management’s attentionto transition matters and identification of suitable replacements, if any, and could have a material adverse effect on our business. Our research and productdevelopment efforts could also be delayed or curtailed if we are unable to attract, train, and retain highly skilled employees, particularly, senior scientists andengineers. We do not maintain fixed term employment contracts or significant key man life insurance with any of our employees.Additionally, to expand our research and product development efforts, we need key scientists skilled in areas such as molecular and cellular biology, assaydevelopment, and manufacturing. We also need highly trained technical support personnel with the necessary scientific background and ability to understand oursystems at a technical level to effectively support potential new customers and the expanding needs of current customers. Competition for these people is intense.Because of the complex and technical nature of our systems and the dynamic market in which we compete, any failure to attract and retain a sufficient number ofqualified employees could materially harm our ability to develop and commercialize our technology.Our efficiency and cost-savings initiatives could be disruptive to our operations and adversely affect our results of operations and financial condition, andwe may not realize some or all of the anticipated benefits of these initiatives in the time frame anticipated or at all.Beginning in the first quarter of 2017, we implemented efficiency and cost-savings initiatives intended to stabilize our business operations and return to growth.We identified areas for cost efficiencies including targeted workforce reductions and optimizing our facilities, and reducing excess space. Other initiatives mayalso include decreasing or deferring capital expenditures and development activities. The implementation of these efficiency and cost-savings initiatives, includingthe impact of workforce reductions, could impair our ability to invest in developing, marketing and selling new and existing products, be disruptive to ouroperations, make it difficult to attract or retain employees, result in higher than anticipated charges, divert the attention of management, result in a loss ofaccumulated knowledge, impact our customer and supplier relationships, and otherwise adversely affect our results of operations and financial condition. Inaddition, our ability to23complete our efficiency and cost-savings initiatives and achieve the anticipated benefits within the expected time frame is subject to estimates and assumptions andmay vary materially from our expectations, including as a result of factors that are beyond our control. Furthermore, our efforts to stabilize our business and returnto growth may not be successful.To use our products, our Biomark, EP1, and Helios/CyTOF 2 systems in particular, customers typically need to purchase specialized reagents. Anyinterruption in the availability of these reagents for use in our products could limit our ability to market our products.Our products, our Biomark, EP1, and Helios/CyTOF 2 systems in particular, must be used in conjunction with one or more reagents designed to produce orfacilitate the particular biological or chemical reaction desired by the user. Many of these reagents are highly specialized and available to the user only from asingle supplier or a limited number of suppliers. Although we sell reagents for use with certain of our products, our customers may purchase these reagents directlyfrom third-party suppliers, and we have no control over the supply of those materials. In addition, our products are designed to work with these reagents as they arecurrently formulated. We have no control over the formulation of reagents sold by third-party suppliers, and the performance of our products might be adverselyaffected if the formulation of these reagents is changed. If one or more of these reagents were to become unavailable or were reformulated, our ability to marketand sell our products could be materially and adversely affected.In addition, the use of a reagent for a particular process may be covered by one or more patents relating to the reagent itself, the use of the reagent for theparticular process, the performance of that process, or the equipment required to perform the process. Typically, reagent suppliers, who are either the patent holdersor their authorized licensees, sell the reagents along with a license or covenant not to sue with respect to such patents. The license accompanying the sale of areagent often purports to restrict the purposes for which the reagent may be used. If a patent holder or authorized licensee were to assert against us or our customersthat the license or covenant relating to a reagent precluded its use with our systems, our ability to sell and market our products could be materially and adverselyaffected. For example, our Biomark system involves real-time quantitative PCR, or qPCR. Leading suppliers of reagents for real-time qPCR reactions include LifeTechnologies Corporation (now part of Thermo Fisher Scientific) and Roche Diagnostics Corporation, who are our direct competitors, and their licensees. Thesereal-time qPCR reagents are typically sold pursuant to limited licenses or covenants not to sue with respect to patents held by these companies. We do not have anycontractual supply agreements for these real-time qPCR reagents, and we cannot assure you that these reagents will continue to be available to our customers foruse with our systems, or that these patent holders will not seek to enforce their patents against us, our customers, or suppliers. Being regulated as a medical device manufacturer by the U.S. Food and Drug Administration, or FDA, and foreign regulatory authorities, and seekingapproval and/or clearance for our products, will take significant time and expense and may not result in FDA clearance or approval for the intended useswe believe are commercially attractive. If our products are successfully approved and/or cleared, we will be subject to ongoing and extensive regulatoryrequirements, which would increase our costs and divert resources away from other projects. If we fail to comply with these requirements, our businessand financial condition could be adversely impacted.Our products are currently labeled, promoted and sold to academic institutions, life sciences laboratories, biopharmaceutical, biotechnology, Ag-Biocompanies and CRO's for research use only, or RUO, and are not designed for, or intended to be used for, diagnostic tests or as medical devices as currentlymarketed. Before we can begin to label and market our products for use as, or in the performance of, clinical diagnostics in the United States, thereby subjectingthem to FDA regulation as medical devices, we would be required to obtain premarket 510(k) clearance or premarket approval (PMA) from the FDA, unless anexception applies.We have announced our plan to register with the FDA as a medical device manufacturer and list some of our products with the FDA pursuant to an FDAClass I listing for general purpose laboratory equipment. We are currently assessing when to make an initial registration. While this regulatory classification isexempt from certain FDA requirements, such as the need to submit a premarket notification commonly known as a 510(k), and most of the requirements of theFDA’s Quality System Regulations, or QSRs, we will be subject to ongoing FDA “general controls,” which include compliance with FDA regulations for labeling,inspections by the FDA, complaint evaluation, corrections and removals reporting, promotional restrictions, reporting adverse events or malfunctions for ourproducts, and general prohibitions against misbranding and adulteration.In addition, we plan to submit 510(k) premarket notifications to the FDA to obtain FDA clearance of certain of our products on a selected basis. Although weplan to submit 510(k) applications for certain of our products, it is possible that the FDA will take the position that a more burdensome premarket application, suchas a premarket approval application or a de novo application is required for some of our products. If such applications are required, greater time and investmentwould be required to obtain FDA approval. Even if the FDA agrees that a 510(k) is appropriate, FDA clearance can be expensive and24time consuming. It generally takes a significant amount of time to prepare a 510(k), including conducting appropriate testing on our products, and several monthsto years for the FDA to review a submission. Notwithstanding the effort and expense, FDA clearance or approval may be denied for some or all of our products.Even if we were to obtain regulatory approval or clearance, it may not be for the intended uses we believe are important or commercially attractive.If we receive regulatory clearance or approval for our products, we will be subject to ongoing FDA obligations and continued regulatory oversight andreview, including the general controls listed above and the FDA’s QSRs for our development and manufacturing operations. In addition, we may be required toobtain a new 510(k) clearance before we can introduce subsequent modifications or improvements to our products. We may also be subject to additional FDA post-marketing obligations, any or all of which would increase our costs and divert resources away from other projects. If we are not able to maintain regulatorycompliance with applicable laws, we may be prohibited from marketing our products for use as, or in the performance of, clinical diagnostics and/or may besubject to enforcement actions, including warning letters and adverse publicity, fines, injunctions, and civil penalties; recall or seizure of products; operatingrestrictions; and criminal prosecution.We intend to seek similar regulatory clearance or approval for our products in countries outside of the United States. Sales of our products outside the UnitedStates will be subject to foreign regulatory requirements, which vary greatly from country to country. As a result, the time required to obtain clearances orapprovals outside the United States may differ from that required to obtain FDA clearance or approval and we may not be able to obtain foreign regulatoryapprovals on a timely basis or at all. Clearance or approval by the FDA does not ensure approval by regulatory authorities in other countries, and approval by oneforeign regulatory authority does not ensure approval by regulatory authorities in other countries or by the FDA. In Europe, we will need to comply with theMedical Device Directive 93/42 EEC and/or the In Vitro Diagnostics Directive 98/79/EC, which are required to market medical devices in the European Union. Inaddition, the FDA regulates exports of medical devices. Failure to comply with these regulatory requirements or obtain and maintain required approvals, clearancesand certifications could impair our ability to commercialize our products for diagnostic use outside of the United States.Our products could become subject to regulation as medical devices by the FDA or other regulatory agencies before we have obtained regulatoryclearance or approval to market our products for diagnostic purposes, which would adversely impact our ability to market and sell our products andharm our business.As products that are currently labeled, promoted and intended for RUO, our products are not currently subject to regulation as medical devices by the FDAor comparable agencies of other countries. However, the FDA or comparable agencies of other countries could disagree with our conclusion that our products arecurrently intended for research use only or deem our current marketing and promotional efforts as being inconsistent with research use only products. For example,our customers may independently elect to use our research use only labeled products in their own laboratory developed tests, or LDTs, for clinical diagnostic use.The FDA has historically exercised enforcement discretion in not enforcing the medical device regulations against laboratories offering LDTs. However, onOctober 3, 2014, the FDA issued two draft guidance documents that set forth the FDA’s proposed risk-based framework for regulating LDTs, which are designed,manufactured, and used within a single laboratory. The draft guidance documents provide the anticipated details through which the FDA would propose toestablish an LDT oversight framework, including premarket review for higher-risk LDTs, such as those that have the same intended use as FDA-approved orcleared companion diagnostics currently on the market. In January, 2017, the FDA announced that it would not issue final guidance on the oversight of LDTs andLDT manufacturers, but would seek further public discussion on an appropriate oversight approach, and give Congress an opportunity to develop a legislativesolution. Any future legislative or administrative rule making or oversight of LDTs and LDT manufacturers, if and when finalized, may impact the sales of ourproducts and how customers use our products, and may require us to change our business model in order to maintain compliance with these laws. We cannotpredict how these various efforts will be resolved, how Congress or the FDA will regulate LDTs in the future, or how that regulatory system will impact ourbusiness.Additionally, on November 25, 2013, the FDA issued Final Guidance “Distribution of In Vitro Diagnostic Products Labeled for Research Use Only.” Theguidance emphasizes that the FDA will review the totality of the circumstances when it comes to evaluating whether equipment and testing components areproperly labeled as RUO. The final guidance states that merely including a labeling statement that the product is for research purposes only will not necessarilyrender the device exempt from the FDA’s clearance, approval, and other regulatory requirements if the circumstances surrounding the distribution of the productindicate that the manufacturer knows its product is, or intends for its product to be, used for clinical diagnostic purposes. These circumstances may include writtenor verbal marketing claims or links to articles regarding a product’s performance in clinical applications and a manufacturer’s provision of technical support forclinical applications.25If the FDA modifies its approach to our products labeled and intended for RUO, or otherwise determines our products or related applications should besubject to additional regulation as in vitro diagnostic devices based upon customers’ use of our products for clinical diagnostic or therapeutic purposes, before wehave obtained regulatory clearance or approval to market our products for diagnostic purposes, our ability to market and sell our products could be impeded andour business, prospects, results of operations and financial condition may be adversely affected. In addition, if the FDA determines that our products labeled forRUO were intended, based on a review of the totality of circumstances, for use in clinical investigation or diagnosis, those products could be consideredmisbranded or adulterated under the Federal Food, Drug, and Cosmetic Act and subject to recall and/or other enforcement action.Compliance or the failure to comply with current and future regulations affecting our products and business operations worldwide, such asenvironmental regulations enacted in the European Union, could cause us significant expense and adversely impact our business.We are subject to many federal, state, local, and foreign regulations relating to various aspects of our business operations. Governmental entities at all levelsare continuously enacting new regulations, and it is difficult to identify all applicable regulations and anticipate how such regulations will be implemented andenforced. We continue to evaluate the necessary steps for compliance with applicable regulations. To comply with applicable regulations, we have and willcontinue to incur significant expense and allocate valuable internal resources to manage compliance-related issues. In addition, such regulations could restrict ourability to expand or equip our facilities, or could require us to acquire costly equipment or to incur other significant expenses to comply with the regulations. Forexample, the Restriction on the Use of Certain Hazardous Substances in Electrical and Electronic Equipment Directive, or RoHS, and the Waste Electrical andElectronic Equipment Directive, or WEEE, enacted in the European Union, regulate the use of certain hazardous substances in, and require the collection, reuse,and recycling of waste from, products we manufacture. Certain of our products sold in these countries are subject to WEEE requirements may become subject toRoHS. These and similar regulations that have been or are in the process of being enacted in other countries may require us to redesign our products, use differenttypes of materials in certain components, or source alternative components to ensure compliance with applicable standards, and may reduce the availability of partsand components used in our products by negatively impacting our suppliers’ ability to source parts and components in a timely and cost-effective manner. Any such redesigns, required use of alternative materials, or limited availability of parts and components used in our products may detrimentally impact theperformance of our products, add greater testing lead times for product introductions, reduce our product margins, or limit the markets for our products, and if wefail to comply with any present and future regulations, we could be subject to future fines, penalties, and restrictions, such as the suspension of manufacturing ofour products or a prohibition on the sale of products we manufacture. Any of the foregoing could adversely affect our business, financial condition, or results ofoperations.If we fail to maintain effective internal control over financial reporting in the future, the accuracy and timing of our financial reporting may be impaired,which could adversely affect our business and our stock price.The Sarbanes-Oxley Act requires, among other things, that we maintain effective internal control over financial reporting and disclosure controls andprocedures. In particular, we must perform system and process evaluation and testing of our internal control over financial reporting to allow management to reporton the effectiveness of our internal control over financial reporting, as required by Section 404 of the Sarbanes-Oxley Act. Our testing may reveal deficiencies inour internal control over financial reporting that are deemed to be material weaknesses.Our compliance with Section 404 requires that we incur substantial accounting expense and expend significant management time on compliance-relatedissues. We currently do not have an internal audit group, and we continue to evaluate our need for additional accounting and financial staff with appropriate publiccompany experience and technical accounting knowledge. Moreover, if we do not comply with the requirements of Section 404, or if we or our independentregistered public accounting firm identify deficiencies in our internal control over financial reporting that are deemed to be material weaknesses, the market priceof our stock could decline and we could be subject to sanctions or investigations by the NASDAQ Global Select Market, or NASDAQ, the SEC or other regulatoryauthorities, which would require additional financial and management resources.26Our future capital needs are uncertain and we may need to raise additional funds in the future, which may cause dilution to stockholders or may be uponterms that are not favorable to us.We believe that our existing cash and cash equivalents will be sufficient to meet our anticipated cash requirements for at least the next 18 months. We havecontinued to experience losses and, if that trend continues, we may need to seek additional sources of financing. In addition, we may need to raise substantialadditional capital for various purposes, including:•expanding the commercialization of our products;•funding our operations;•furthering our research and development; and•acquiring other businesses or assets and licensing technologies. Our future funding requirements will depend on many factors, including:•market acceptance of our products;•the cost of our research and development activities;•the cost of filing and prosecuting patent applications;•the cost of defending any litigation including intellectual property, employment, contractual or other litigation;•the cost and timing of regulatory clearances or approvals, if any;•the cost and timing of establishing additional sales, marketing, and distribution capabilities;•the cost and timing of establishing additional technical support capabilities;•the effectiveness of our recent efficiency and cost-savings initiatives;•the effect of competing technological and market developments; and•the extent to which we acquire or invest in businesses, products, and technologies, although we currently have no commitments or agreements relating toany of these types of transactions.We cannot assure you that we will be able to obtain additional funds on acceptable terms, or at all. If we raise additional funds by issuing equity securities,our stockholders may experience dilution. Debt financing, if available, may involve covenants restricting our operations or our ability to incur additional debt. Anyadditional debt or equity financing that we raise may contain terms that are not favorable to us or our stockholders. If we raise additional funds throughcollaboration and licensing arrangements with third parties, it may be necessary to relinquish some rights to our technologies or our products, or grant licenses onterms that are not favorable to us. If we are unable to raise adequate funds, we may have to liquidate some or all of our assets, delay development orcommercialization of our products, or license to third parties the rights to commercialize products or technologies that we would otherwise seek to commercialize.We also may have to reduce marketing, customer support, or other resources devoted to our products, or cease operations. Any of these factors could harm ouroperating results.We are subject to risks related to taxation in multiple jurisdictions and if taxing authorities disagree with our interpretations of existing tax laws orregulations, our effective income tax rate could be adversely affected and we could have additional tax liability.We are subject to income taxes in both the United States and certain foreign jurisdictions. Significant judgments based on interpretations of existing tax lawsor regulations are required in determining the provision for income taxes. For example, we have made certain interpretations of existing tax laws or regulationsbased upon the operations of our business internationally and we have implemented intercompany agreements based upon these interpretations and related transferpricing analyses. If the U.S. Internal Revenue Service or other taxing authorities disagree with the positions, our effective income tax rate could be adverselyaffected and we could have additional tax liability, including interest and penalties. We recently completed a review of our European corporate structure and taxpositions and, based upon our existing business operations, we plan to restructure27our European intercompany transactions, which is likely to increase our income tax liability. From time to time, we may review our corporate structure and taxpositions in other international jurisdictions and such review may result in additional changes to how we structure our international business operations, which mayadversely impact our effective income tax rate. Our effective income tax rate could also be adversely affected by changes in the mix of earnings in tax jurisdictionswith different statutory tax rates, changes in the valuation of deferred tax assets and liabilities, changes in existing tax laws or tax rates, changes in the level of non-deductible expenses (including share-based compensation), changes in our future levels of research and development spending, mergers and acquisitions, or theresult of examinations by various tax authorities. Payment of additional amounts upon final adjudication of any disputes could have a material impact on ourresults of operations and financial position.Adverse conditions in the global economy and disruption of financial markets may significantly harm our revenue, profitability, and results of operations.The global credit and financial markets have in recent years experienced volatility and disruptions, including diminished liquidity and credit availability,increased concerns about inflation and deflation, and the downgrade of U.S. debt and exposure risks on other sovereign debts, decreased consumer confidence,lower economic growth, volatile energy costs, increased unemployment rates, and uncertainty about economic stability. Volatility and disruption of financialmarkets could limit our customers’ ability to obtain adequate financing or credit to purchase and pay for our products in a timely manner or to maintain operations,which could result in a decrease in sales volume that could harm our results of operations. General concerns about the fundamental soundness of domestic andinternational economies may also cause our customers to reduce their purchases. Changes in governmental banking, monetary, and fiscal policies to addressliquidity and increase credit availability may not be effective. Significant government investment and allocation of resources to assist the economic recovery ofsectors which do not include our customers may reduce the resources available for government grants and related funding for life science, Ag-Bio, and clinicalresearch and development. Continuation or further deterioration of these financial and macroeconomic conditions could significantly harm our sales, profitability,and results of operations.If we are unable to integrate future acquisitions successfully, our operating results and prospects could be harmed.In addition to our acquisition of DVS, we may make additional acquisitions to improve our product offerings or expand into new markets. Our futureacquisition strategy will depend on our ability to identify, negotiate, complete, and integrate acquisitions and, if necessary, to obtain satisfactory debt or equityfinancing to fund those acquisitions. Mergers and acquisitions are inherently risky, and any transaction we complete may not be successful. Our acquisition of DVSwas our first acquisition of another company. Any merger or acquisition we may pursue would involve numerous risks, including but not limited to the following:•difficulties in integrating and managing the operations, technologies, and products of the companies we acquire;•diversion of our management’s attention from normal daily operation of our business;•our inability to maintain the key business relationships and the reputations of the businesses we acquire;•our inability to retain key personnel of the acquired company;•uncertainty of entry into markets in which we have limited or no prior experience and in which competitors have stronger market positions;•our dependence on unfamiliar affiliates and customers of the companies we acquire;•insufficient revenue to offset our increased expenses associated with acquisitions;•our responsibility for the liabilities of the businesses we acquire, including those which we may not anticipate; and•our inability to maintain internal standards, controls, procedures, and policies.We may be unable to secure the equity or debt funding necessary to finance future acquisitions on terms that are acceptable to us. If we finance acquisitionsby issuing equity or convertible debt securities, our existing stockholders will likely experience dilution, and if we finance future acquisitions with debt funding,we will incur interest expense and may have to comply with financial covenants and secure that debt obligation with our assets.28If we are unable to manage our anticipated growth effectively, our business could be harmed.The rapid growth of our business over time has placed a significant strain on our managerial, operational, and financial resources and systems. To executeour anticipated growth successfully, we must continue to attract and retain qualified personnel and manage and train them effectively. We must also upgrade ourinternal business processes and capabilities to create the scalability that a growing business demands.We believe our facilities located in Singapore, Canada, and California, are sufficient to meet our short-term manufacturing needs. The current lease for ourmanufacturing facility in Singapore expires in June 2022. In the event that we need to add to our existing manufacturing space in Singapore or move ourmanufacturing facility to a new location in Singapore, such a move will involve significant expense and efforts in connection with the establishment of new cleanrooms and the recommissioning of key manufacturing equipment. In August 2015, we entered into a lease for new office, laboratory and warehouse space inCanada and relocated our Canada operations to the new space in April 2016. This Canada lease expires in March 2026. A move of any of our manufacturingfacilities may delay or otherwise adversely affect our manufacturing activities and business.Further, our anticipated growth will place additional strain on our suppliers and manufacturing facilities, resulting in an increased need for us to carefullymonitor quality assurance. Any failure by us to manage our anticipated growth effectively could have an adverse effect on our ability to achieve our developmentand commercialization goals.If we are unable to expand our direct sales and marketing force or distribution capabilities to adequately address our customers’ needs, our business maybe adversely affected.We may not be able to market, sell, and, distribute our products effectively enough to support our planned growth. We sell our products primarily throughour own sales force and through distributors in certain territories. Our future sales will depend in large part on our ability to develop and substantially expand ourdirect sales force and to increase the scope of our marketing efforts. Our products are technically complex and used for highly specialized applications. As a result,we believe it is necessary to develop a direct sales force that includes people with specific scientific backgrounds and expertise, and a marketing group withtechnical sophistication. Competition for such employees is intense. We may not be able to attract and retain personnel or be able to build an efficient and effectivesales and marketing force, which could negatively impact sales of our products and reduce our revenue and profitability.In addition, we may continue to enlist one or more sales representatives and distributors to assist with sales, distribution, and customer support globally or incertain regions of the world. If we do seek to enter into such arrangements, we may not be successful in attracting desirable sales representatives and distributors,or we may not be able to enter into such arrangements on favorable terms. If our sales and marketing efforts, or those of any third-party sales representatives anddistributors, are not successful, our technologies and products may not gain market acceptance, which would materially and adversely impact our businessoperations.Risks associated with a company-wide implementation of an enterprise resource planning, or ERP, system may adversely affect our business and resultsof operations or the effectiveness of internal control over financial reporting.We have been implementing a company-wide ERP system to handle the business and financial processes within our operations and corporate functions. ERPimplementations are complex and time-consuming projects that involve substantial expenditures on system software and implementation activities that cancontinue for several years. ERP implementations also require transformation of business and financial processes in order to reap the benefits of the ERP system.Our business and results of operations may be adversely affected if we experience operating problems and/or cost overruns during the ERP implementationprocess, or if the ERP system and the associated process changes do not give rise to the benefits that we expect. If we do not effectively implement the ERP systemas planned or if the system does not operate as intended, our business, results of operations, and internal controls over financial reporting may be adverselyaffected.Changes in accounting principles, or interpretations thereof, could have a significant impact on our financial position and results of operations.We prepare our consolidated financial statements in accordance with accounting principles generally accepted in the United States of America, referred to asU.S. GAAP. These principles are subject to interpretation by the SEC and various bodies formed to interpret and create appropriate accounting principles. Achange in these principles can have a significant effect on our reported results and may even retroactively affect previously reported transactions. Additionally, theadoption of new or revised accounting principles may require that we make significant changes to our systems, processes and controls.29For example, the U.S.-based Financial Accounting Standards Board, referred to as FASB, is currently working together with the International AccountingStandards Board, referred to IASB, on several projects to further align accounting principles and facilitate more comparable financial reporting between companieswho are required to follow U.S. GAAP under SEC regulations and those who are required to follow International Financial Reporting Standards outside of theUnited States. These efforts by the FASB and IASB may result in different accounting principles under U.S. GAAP that may result in materially different financialresults for us in areas including, but not limited to, principles for recognizing revenue and lease accounting. Additionally, significant changes to U.S. GAAPresulting from the FASB’s and IASB’s efforts may require that we change how we process, analyze and report financial information and that we change financialreporting controls. Additionally, the FASB issued new guidance relating to Revenue from Contracts with Customers which supersedes nearly all existing U.S.GAAP revenue recognition guidance. The new guidance will be effective for our fiscal year 2018. Although we are currently in the process of evaluating theimpact of this new guidance on our consolidated financial statements, it could change the way we account for certain of our sales transactions. Thus, adoption ofthe standard could have a significant impact on our financial statements and may retroactively affect the accounting treatment of transactions completed beforeadoption.It is not clear if or when these potential changes in accounting principles may become effective, whether we have the proper systems and controls in place toaccommodate such changes and the impact that any such changes may have on our financial position and results of operations.Our ability to use net operating loss carryforwards to offset future taxable income for U.S. federal income tax purposes and other tax benefits may belimited.Section 382 of the Internal Revenue Code of 1986, as amended, referred to as the “Code,” imposes an annual limitation on the amount of taxable income thatmay be offset if a corporation experiences an “ownership change” as defined in Section 382 of the Code. An ownership change occurs when a company’s “five-percent shareholders” (as defined in Section 382 of the Code) collectively increase their ownership in the company by more than 50 percentage points (by value)over a rolling three-year period. Additionally, various states have similar limitations on the use of state net operating losses, referred to as our NOL's, following anownership change .If we experience an ownership change, our ability to use our NOLs, any loss or deduction attributable to a “net unrealized built-in loss” and other taxattributes, which we refer to as tax benefits, could be substantially limited, and the timing of the usage of the tax benefits could be substantially delayed, whichcould significantly impair the value of the tax benefits. There is no assurance that we will be able to fully utilize the tax benefits and we could be required torecord an additional valuation allowance related to the amount of the tax benefits that may not be realized, which could adversely impact our results of operations.We believe that these tax benefits are a valuable asset for us. On November 21, 2016, our board of directors approved a Tax Benefit Preservation Plan, or taxbenefit preservation plan in an effort to protect our tax benefits during the effective period of the tax benefit preservation plan. The tax benefit preservation plan isexpected to be submitted to a stockholder vote at our 2017 annual meeting of stockholders. If our stockholders do not approve the tax benefit preservation plan, itwill expire. Although the tax benefit preservation plan is intended to reduce the likelihood of an “ownership change” that could adversely affect us, there is noassurance that the tax benefit preservation plan will prevent acquisitions in our common stock that could result in such an “ownership change.”The tax benefit preservation plan could make it more difficult for a third party to acquire, or could discourage a third party from acquiring, us or a largeblock of our common stock. A third party that acquires 4.99% or more of our common stock could suffer substantial dilution of its ownership interest under theterms of the tax benefit preservation plan through the issuance of common stock or common stock equivalents to all stockholders other than the acquiring person.The foregoing provisions may adversely affect the marketability of our common stock by discouraging potential investors from acquiring our stock. Inaddition, these provisions could delay or frustrate the removal of incumbent directors and could make a merger, tender offer or proxy contest involving us moredifficult, or impede an attempt to acquire a significant or controlling interest in us, even if such events might be beneficial to us and our stockholders.30Risks Related to Intellectual PropertyOur ability to protect our intellectual property and proprietary technology through patents and other means is uncertain.Our commercial success depends in part on our ability to protect our intellectual property and proprietary technologies. We rely on patent protection, whereappropriate and available, as well as a combination of copyright, trade secret, and trademark laws, and nondisclosure, confidentiality, and other contractualrestrictions to protect our proprietary technology. However, these legal means afford only limited protection and may not adequately protect our rights or permit usto gain or keep any competitive advantage. We apply for patents covering our products and technologies and uses thereof, as we deem appropriate. However, wemay fail to apply for patents on important products and technologies in a timely fashion or at all. Our pending U.S. and foreign patent applications may not issue aspatents or may not issue in a form that will be sufficient to protect our proprietary technology and gain or keep our competitive advantage. Any patents we haveobtained or do obtain may be subject to re-examination, reissue, opposition, or other administrative proceeding, or may be challenged in litigation, and suchchallenges could result in a determination that the patent is invalid or unenforceable. In addition, competitors may be able to design alternative methods or devicesthat avoid infringement of our patents. Both the patent application process and the process of managing patent disputes can be time consuming and expensive.Furthermore, the laws of some foreign countries may not protect our intellectual property rights to the same extent as do the laws of the United States, andmany companies have encountered significant problems in protecting and defending such rights in foreign jurisdictions. Proceedings to enforce our patent rights inforeign jurisdictions could result in substantial cost and divert our efforts and attention from other aspects of our business. Changes in either the patent laws or ininterpretations of patent laws in the United States or other countries may diminish the value of our intellectual property. We cannot predict the breadth of claimsthat may be allowed or enforced in our patents or in third-party patents. For example:•We might not have been the first to make the inventions covered by each of our pending patent applications;•We might not have been the first to file patent applications for these inventions;•The patents of others may have an adverse effect on our business; and•Others may independently develop similar or alternative products and technologies or duplicate any of our products and technologies.To the extent our intellectual property, including licensed intellectual property, offers inadequate protection, or is found to be invalid or unenforceable, ourcompetitive position and our business could be adversely affected.We may be involved in lawsuits to protect or enforce our patents and proprietary rights, to determine the scope, coverage and validity of others’proprietary rights, or to defend against third party claims of intellectual property infringement, any of which could be time-intensive and costly and mayadversely impact our business or stock price.Litigation may be necessary for us to enforce our patent and proprietary rights, determine the scope, coverage, and validity of others’ proprietary rights,and/or defend against third party claims of intellectual property infringement against us as well as against our suppliers, distributors, customers, and other entitieswith whom we do business. Litigation could result in substantial legal fees and could adversely affect the scope of our patent protection. The outcome of anylitigation or other proceeding is inherently uncertain and might not be favorable to us, and we might not be able to obtain licenses to technology that we require.Even if such licenses are obtainable, they may not be available at a reasonable cost. We could therefore incur substantial costs related to royalty payments forlicenses obtained from third parties, which could negatively affect our product margins or financial position. Further, we could encounter delays in productintroductions, or interruptions in product sales, as we develop alternative methods or products.As we move into new markets and applications for our products, incumbent participants in such markets may assert their patents and other proprietary rightsagainst us as a means of impeding our entry into such markets or as a means to extract substantial license and royalty payments from us. Our commercial successmay depend in part on our non-infringement of the patents or proprietary rights of third parties. Numerous significant intellectual property issues have beenlitigated, and will likely continue to be litigated, between existing and new participants in our existing and targeted markets. For example, some of our productsprovide for the testing and analysis of genetic material, and patent rights relating to genetic materials remain a developing area of patent law. A recent U.S.Supreme Court decision held, among other things, that claims to isolated genomic DNA occurring in nature are not patent eligible, while claims relating tosynthetic DNA may be patent eligible. We expect the31ruling will result in additional litigation in our industry. In addition, third parties may assert that we are employing their proprietary technology withoutauthorization. For example, on June 4, 2008 we received a letter from Applied Biosystems, Inc., a wholly-owned subsidiary of Life Technologies Corporation(now part of Thermo Fisher Scientific Inc. and collectively referred to as Life), asserting that our Biomark system for gene expression analysis infringes upon U.S.Patent No. 6,814,934, or the ‘934 patent, and its foreign counterparts in Europe and Canada. In June 2011, we resolved this dispute by entering into licenseagreements with Life which, among other matters, granted us a non-exclusive license to the ‘934 patent and its foreign counterparts.Our customers have been sued for various claims of intellectual property infringement in the past, and we expect that our customers will be involved inadditional litigation in the future. In particular, our customers may become subject to lawsuits claiming that their use of our products infringes third-party patentrights, and we could become subject to claims that we contributed to or induced our customer’s infringement. In addition, our agreements with some of oursuppliers, distributors, customers, and other entities with whom we do business may require us to defend or indemnify these parties to the extent they becomeinvolved in infringement claims against us, including the claims described above. We could also voluntarily agree to defend or indemnify third parties in instanceswhere we are not obligated to do so if we determine it would be important to our business relationships. If we are required or agree to defend or indemnify any ofthese third parties in connection with any infringement claims, we could incur significant costs and expenses that could adversely affect our business, operatingresults, or financial condition.We may be subject to damages resulting from claims that we or our employees have wrongfully used or disclosed alleged trade secrets of our employees’former employers or other institutions or third parties with whom such employees may have been previously affiliated.Many of our employees were previously employed at universities or other life science or Ag-Bio companies, including our competitors or potentialcompetitors. We are currently and may become in the future subject to claims that our employees or we have inadvertently or otherwise used or disclosed tradesecrets or other proprietary information of their former employers or other third parties or institutions with whom our employees may have been previouslyaffiliated. Litigation may be necessary to defend against these claims. For example, we are currently a defendant in litigation brought against us and one of ournon-executive employees by Thermo Fisher Scientific Inc. alleging, among other claims, misappropriation of proprietary information and breach of contractual andfiduciary obligations. The case is in its early stages, and we are unable to determine the ultimate outcome or estimate the range of potential losses. We intend todefend the case vigorously. If we fail in defending such claims, in addition to paying monetary damages, we may be subject to injunctive relief against us. A lossof key research personnel work product could hamper or prevent our ability to commercialize certain potential products or a loss of or inability to hire keymarketing, sales or research and development personnel could adversely affect our future product development, sales and revenues, any of which could severelyharm our business. Even if we are successful in defending against these claims, litigation could result in substantial costs and be a distraction to management.We depend on certain technologies that are licensed to us. We do not control these technologies and any loss of our rights to them could prevent us fromselling our products, which would have an adverse effect on our business.We rely on licenses in order to be able to use various proprietary technologies that are material to our business, including our core IFC, multi-layer softlithography, and mass cytometry technologies. In some cases, we do not control the prosecution, maintenance, or filing of the patents to which we hold licenses, orthe enforcement of these patents against third parties. Additionally, our business and product development plans anticipate and may substantially depend on futurein-license agreements with additional third parties, some of which are currently in the early discussion phase. For example, Fluidigm Canada Inc., or FluidigmCanada, an Ontario corporation and wholly-owned subsidiary of Fluidigm Sciences, was party to an interim license agreement, now expired, with Nodality, Inc., orNodality, under which Nodality granted Fluidigm Canada a worldwide, non-exclusive, research use only, royalty bearing license to certain cytometric reagents,instruments, and other products. We have had prior discussions with Nodality to reinstate the license agreement. We cannot provide assurances that we will be ableto reinstate the license agreement with Nodality or secure a new license agreement with Nodality or other third parties on acceptable terms, if at all.In-licensed intellectual property rights that are fundamental to the business being operated present numerous risks and limitations. For example, all or aportion of the license rights granted may be limited for research use only, and in the event we attempt to expand into diagnostic applications, we would be requiredto negotiate additional rights, which may not be available to us on commercially reasonable terms, if at all.Our rights to use the technology we license are also subject to the negotiation and continuation of those licenses. Certain of our licenses contain provisionsthat allow the licensor to terminate the license upon specific conditions. Our rights under the32licenses are subject to our continued compliance with the terms of the license, including the payment of royalties due under the license. Because of the complexityof our products and the patents we have licensed, determining the scope of the license and related royalty obligation can be difficult and can lead to disputesbetween us and the licensor. An unfavorable resolution of such a dispute could lead to an increase in the royalties payable pursuant to the license. If a licensorbelieved we were not paying the royalties due under the license or were otherwise not in compliance with the terms of the license, the licensor might attempt torevoke the license. If such an attempt were successful and the license is terminated, we might be barred from marketing, producing, and selling some or all of ourproducts, which would have an adverse effect on our business. Potential disputes between us and one of our existing licensors concerning the terms or conditionsof the applicable license agreement could result, among other risks, in substantial management distraction; increased expenses associated with litigation or effortsto resolve disputes; substantial customer uncertainty concerning the direction of our product lines; potential infringement claims against us and/or our customers,which could include efforts by a licensor to enjoin sales of our products; customer requests for indemnification by us; and, in the event of an adverse determination,our inability to operate our business as currently operated. Termination of material license agreements could prevent us from manufacturing and selling ourproducts unless we can negotiate new license terms or develop or acquire alternative intellectual property rights that cover or enable similar functionality. Any ofthese factors would be expected to have a material adverse effect on our business, operating results, and financial condition and could result in a substantial declinein our stock price.We are subject to certain manufacturing restrictions related to licensed technologies that were developed with the financial assistance of U.S.governmental grants.We are subject to certain U.S. government regulations because we have licensed technologies that were developed with U.S. government grants. Inaccordance with these regulations, these licenses provide that products embodying the technologies are subject to domestic manufacturing requirements. If thisdomestic manufacturing requirement is not met, the government agency that funded the relevant grant is entitled to exercise specified rights, referred to as “march-in rights,” which if exercised would allow the government agency to require the licensors or us to grant a non-exclusive, partially exclusive, or exclusive license inany field of use to a third party designated by such agency. All of our microfluidic systems revenue is dependent upon the availability of our IFCs, whichincorporate technology developed with U.S. government grants. All of our instruments, including microfluidic systems, and IFCs for commercial sale aremanufactured at our facility in Singapore. The federal regulations allow the funding government agency to grant, at the request of the licensors of such technology,a waiver of the domestic manufacturing requirement. Waivers may be requested prior to any government notification. We have assisted the licensors of thesetechnologies with the analysis of the domestic manufacturing requirement, and, in December 2008, the sole licensor subject to the requirement applied for a waiverof the domestic manufacturing requirement with respect to the relevant patents licensed to us by this licensor. In July 2009, the funding government agency grantedthe requested waiver of the domestic manufacturing requirement for a three-year period commencing in July 2009. In June 2012, the licensor requested a continuedwaiver of the domestic manufacturing requirement with respect to the relevant patents, but the government agency has not yet taken any action in response to thisrequest. If the government agency does not grant the requested waiver or the government fails to grant additional waivers of such requirement that may be soughtin the future, then the U.S. government could exercise its march-in rights with respect to the relevant patents licensed to us. In addition, the license agreementunder which the relevant patents are licensed to us contains provisions that obligate us to comply with this domestic manufacturing requirement. We are notcurrently manufacturing instruments and IFCs in the United States that incorporate the relevant licensed technology. If our lack of compliance with this provisionconstituted a material breach of the license agreement, the license of the relevant patents could be terminated or we could be compelled to relocate ourmanufacturing of microfluidic systems and IFCs to the United States to avoid or cure a material breach of the license agreement. Any of the exercise of march-inrights, the termination of our license of the relevant patents or the relocation of our manufacturing of microfluidic systems and IFCs to the United States couldmaterially adversely affect our business, operations and financial condition.We may be subject to information technology failures, including data protection breaches and cyber-attacks, that could disrupt our operations, damageour reputation and adversely affect our business, operations, and financial results.We rely on our information technology systems for the effective operation of our business and for the secure maintenance and storage of confidential datarelating to our business and third party businesses. Although we have implemented security controls to protect our information technology systems, experiencedprogrammers or hackers may be able to penetrate our security controls, and develop and deploy viruses, worms, and other malicious software programs thatcompromise our confidential information or that of third parties and cause a disruption or failure of our information technology systems. Any such compromise ofour information technology systems could result in the unauthorized publication of our confidential business or proprietary information, result in the unauthorizedrelease of customer, supplier or employee data, result in a violation of privacy or other laws, expose us to a risk of litigation, or damage our reputation. The costand operational consequences of implementing further data protection measures either as a response to specific breaches or as a result of evolving risks, could besignificant. In addition, our inability to use or access our information systems at critical points in time33could adversely affect the timely and efficient operation of our business. Any delayed sales, significant costs or lost customers resulting from these technologyfailures could adversely affect our business, operations, and financial results.Third parties with which we conduct business have access to certain portions of our sensitive data. In the event that these third parties do not properlysafeguard our data that they hold, security breaches could result and negatively impact our business, operations, and financial results.We are subject to certain obligations and restrictions relating to technologies developed in cooperation with Canadian government agencies.Some of our Canadian research and development is funded in part through government grants and by government agencies. The intellectual propertydeveloped through these projects is subject to rights and restrictions in favor of government agencies and Canadians generally. In most cases the governmentagency retains the right to use intellectual property developed through the project for non-commercial purposes and to publish the results of research conducted inconnection with the project. This may increase the risk of public disclosure of information relating to our intellectual property, including confidential information,and may reduce its competitive advantage in commercializing intellectual property developed through these projects. In certain projects, we have also agreed to usecommercially reasonable efforts to commercialize intellectual property in Canada, or more specifically in the province of Ontario, for the economic benefit ofCanada and the province of Ontario. These restrictions will limit our choice of business and manufacturing locations, business partners and corporate structure andmay, in certain circumstances, restrict our ability to achieve maximum profitability and cost efficiency from the intellectual property generated by these projects. Inone instance, a dispute with the applicable government funded entity may require mediation, which could lead to unanticipated delays in our commercializationefforts to that project. One of our Canadian government funded projects is also subject to certain limited “march-in” rights in favor of the government of theProvince of Ontario, under which we may be required to grant a license to our intellectual property, including background intellectual property developed outsidethe scope of the project, to a responsible applicant on reasonable terms in circumstances where the government determines that such a license is necessary in orderto alleviate emergency or extraordinary health or safety needs or for public use. In addition, we must provide reasonable assistance to the government in obtainingsimilar licenses from third parties required in connection with the use of its intellectual property. Instances in which the government of the Province of Ontario hasexercised similar “march-in” rights are rare; however, the exercise of such rights could materially adversely affect our business, operations and financial condition.Risks Related to Our Common StockOur stock price may fluctuate significantly, particularly if holders of substantial amounts of our stock attempt to sell, and holders may have difficultyselling their shares based on current trading volumes of our stock. In addition, numerous other factors could result in substantial volatility in the tradingprice of our stock.Our stock is currently traded on NASDAQ, but we can provide no assurance that we will be able to maintain an active trading market on NASDAQ or anyother exchange in the future. The trading volume of our stock tends to be low relative to our total outstanding shares, and we have several stockholders who holdsubstantial blocks of our stock. As of December 31, 2016, we had 29,207,654 shares of common stock outstanding, and stockholders holding at least 5% of ourstock, individually or with affiliated persons or entities, collectively beneficially owned or controlled approximately 77.9% of such shares. Sales of large numbersof shares by any of our large stockholders could adversely affect our trading price, particularly given our relatively small historic trading volumes. If stockholdersholding shares of our common stock sell, indicate an intention to sell, or if it is perceived that they will sell, substantial amounts of their common stock in thepublic market, the trading price of our common stock could decline. Moreover, if there is no active trading market or if the volume of trading is limited, holders ofour common stock may have difficulty selling their shares.In addition, the trading price of our common stock may be highly volatile and could be subject to wide fluctuations in response to various factors, some ofwhich are beyond our control. These factors include:•actual or anticipated quarterly variation in our results of operations or the results of our competitors;•announcements or communications by us or our competitors relating to, among other things, new commercial products, technological advances,significant contracts, commercial relationships, capital commitments, acquisitions or sales of businesses, and/or misperceptions in or speculation by themarket regarding such announcements or communications;34•issuance of new or changed securities analysts’ reports or recommendations for our stock;•developments or disputes concerning our intellectual property or other proprietary rights;•commencement of, or our involvement in, litigation;•market conditions in the life science, Ag-Bio, and CRO sectors;•failure to complete significant sales;•manufacturing disruptions that could occur if we were unable to successfully expand our production in our current or an alternative facility;•any future sales of our common stock or other securities in connection with raising additional capital or otherwise;•any major change to the composition of our board of directors or management; and•general economic conditions and slow or negative growth of our markets.The stock market in general, and market prices for the securities of technology-based companies like ours in particular, have from time to time experiencedvolatility that often has been unrelated to the operating performance of the underlying companies. These broad market and industry fluctuations may adverselyaffect the market price of our common stock regardless of our operating performance. In several recent situations where the market price of a stock has beenvolatile, holders of that stock have instituted securities class action litigation against the company that issued the stock. If any of our stockholders were to bring alawsuit against us, the defense and disposition of the lawsuit could be costly and divert the time and attention of our management and harm our operating results.If securities or industry analysts publish unfavorable research about our business or cease to cover our business, our stock price and/or trading volumecould decline.The trading market for our common stock may rely, in part, on the research and reports that equity research analysts publish about us and our business. Wedo not have any control of the analysts or the content and opinions included in their reports. The price of our stock could decline if one or more equity researchanalysts downgrade our stock or issue other unfavorable commentary or research. If one or more equity research analysts ceases coverage of our company or failsto publish reports on us regularly, demand for our stock could decrease, which in turn could cause our stock price or trading volume to decline.Anti-takeover provisions in our charter documents, our tax benefit preservation plan, and under Delaware law could make an acquisition of us, whichmay be beneficial to our stockholders, more difficult and may prevent attempts by our stockholders to replace or remove our current management andlimit the market price of our common stock.Provisions in our certificate of incorporation and bylaws may have the effect of delaying or preventing a change of control or changes in our management,including provisions that:•authorize our board of directors to issue, without further action by the stockholders, up to 10,000,000 shares of undesignated preferred stock;•require that any action to be taken by our stockholders be effected at a duly called annual or special meeting and not by written consent;•specify that special meetings of our stockholders can be called only by our board of directors, the chairman of the board, the chief executive officer orthe president;•establish an advance notice procedure for stockholder approvals to be brought before an annual meeting of our stockholders, including proposednominations of persons for election to our board of directors;•establish that our board of directors is divided into three classes, Class I, Class II, and Class III, with each class serving staggered three year terms;•provide that our directors may be removed only for cause;35•provide that vacancies on our board of directors may be filled only by a majority of directors then in office, even though less than a quorum;•specify that no stockholder is permitted to cumulate votes at any election of directors; and•require a super-majority of votes to amend certain of the above-mentioned provisions.These provisions may frustrate or prevent any attempts by our stockholders to replace or remove our current management by making it more difficult forstockholders to replace members of our board of directors, which is responsible for appointing the members of our management. In addition, because we areincorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporation Law, which limits the ability of stockholdersowning in excess of 15% of our outstanding voting stock to merge or combine with us.In addition, the tax benefit preservation plan that we adopted in November 2016 could make an acquisition of us more difficult. The risks associated with thetax benefit preservation plan are described in more detail above under the heading “ O ur ability to use net operating loss carryforwards to offset future taxableincome for U.S. federal income tax purposes and other tax benefits may be limited.”We have never paid cash dividends on our capital stock, and we do not anticipate paying any cash dividends in the foreseeable future.We have paid no cash dividends on any of our classes of capital stock to date and currently intend to retain our future earnings to fund the development andgrowth of our business. In addition, we may become subject to covenants under future debt arrangements that place restrictions on our ability to pay dividends. Asa result, capital appreciation, if any, of our common stock will be stockholders’ sole source of gain for the foreseeable future.Risks Related to Our Outstanding 2.75% Senior Convertible Notes due 2034Our outstanding 2.75% senior convertible notes due 2034 are effectively subordinated to our secured debt and any liabilities of our subsidiaries.Our outstanding 2.75% senior convertible notes due 2034, which we refer to as our “notes”, rank:•senior in right of payment to any of our indebtedness that is expressly subordinated in right of payment to the notes;•equal in right of payment to all of our liabilities that are not so subordinated;•effectively junior in right of payment to any of our secured indebtedness to the extent of the value of the assets securing such indebtedness; and•structurally junior to all indebtedness and other liabilities (including trade payables) of our subsidiaries.In February 2014, we completed our offering of notes with an aggregate outstanding principal amount of $201.3 million. In the event of our bankruptcy,liquidation, reorganization, or other winding up, our assets that secure debt ranking senior in right of payment to the notes will be available to pay obligations onthe notes only after the secured debt has been repaid in full from these assets, and the assets of our subsidiaries will be available to pay obligations on the notesonly after all claims senior to the notes have been repaid in full. There may not be sufficient assets remaining to pay amounts due on any or all of the notes thenoutstanding. The indenture governing the notes does not prohibit us from incurring additional senior debt or secured debt, nor does it prohibit our subsidiaries fromincurring additional liabilities.The notes are our obligations only and some of our operations are conducted through, and a portion of our consolidated assets are held by, oursubsidiaries.The notes are our obligations exclusively and are not guaranteed by any of our operating subsidiaries. A portion of our consolidated assets is held by oursubsidiaries. Accordingly, our ability to service our debt, including the notes, depends in part on the results of operations of our subsidiaries and upon the ability ofsuch subsidiaries to provide us with cash, whether in the form of dividends, loans, or otherwise, to pay amounts due on our obligations, including the notes. Oursubsidiaries are separate and distinct legal entities and have no obligation, contingent or otherwise, to make payments on the notes or to make any funds36available for that purpose. In addition, dividends, loans, or other distributions to us from such subsidiaries may be subject to contractual and other restrictions andare subject to other business and tax considerations.Recent and future regulatory actions and other events may adversely affect the trading price and liquidity of the notes.We expect that many investors in, and potential purchasers of, the notes will employ, or seek to employ, a convertible arbitrage strategy with respect to thenotes. Investors would typically implement such a strategy by selling short the common stock underlying the notes and dynamically adjusting their short positionwhile continuing to hold the notes. Investors may also implement this type of strategy by entering into swaps on our common stock in lieu of or in addition to shortselling the common stock. As a result, any specific rules regulating equity swaps or short selling of securities or other governmental action that interferes with theability of market participants to effect short sales or equity swaps with respect to our common stock could adversely affect the ability of investors in, or potentialpurchasers of, the notes to conduct the convertible arbitrage strategy that we believe they will employ, or seek to employ, with respect to the notes. This could, inturn, adversely affect the trading price and liquidity of the notes.The SEC and other regulatory and self-regulatory authorities have implemented various rules and taken certain actions, and may in the future adoptadditional rules and take other actions, that may impact those engaging in short selling activity involving equity securities (including our common stock). Suchrules and actions include Rule 201 of SEC Regulation SHO, the adoption by the Financial Industry Regulatory Authority, Inc. and the national securities exchangesof a “Limit Up-Limit Down” program, the imposition of market-wide circuit breakers that halt trading of securities for certain periods following specific marketdeclines, and the implementation of certain regulatory reforms required by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010. Althoughthe direction and magnitude of the effect that Regulation SHO, FINRA, securities exchange rule changes, and implementation of the Dodd-Frank Act may have onthe trading price and the liquidity of the notes will depend on a variety of factors, many of which cannot be determined at the date of this report, past regulatoryactions (such as certain emergency orders issued by the SEC in 2008 prohibiting short sales of stock of certain financial services companies) have had a significantimpact on the trading prices and liquidity of convertible debt instruments. Any governmental or regulatory action that restricts the ability of investors in, orpotential purchasers of, the notes to effect short sales of our common stock, borrow our common stock, or enter into swaps on our common stock or increases thecosts of implementing an arbitrage strategy could adversely affect the trading price and the liquidity of the notes.Volatility in the market price and trading volume of our common stock could adversely impact the trading price of the notes.The stock market in recent years has experienced significant price and volume fluctuations that have often been unrelated to the operating performance ofcompanies. The market price of our common stock could fluctuate significantly for many reasons, including in response to the risks described in this report, or forreasons unrelated to our operations, such as reports by industry analysts, investor perceptions or negative announcements by our customers, competitors orsuppliers regarding their own performance, as well as industry conditions and general financial, economic and political instability. The market price of ourcommon stock could also decline as a result of sales of a large number of shares of our common stock in the market, particularly sales by our directors, executiveofficers, employees, and significant stockholders, and the perception that these sales could occur may also depress the market price of our common stock. Adecrease in the market price of our common stock would likely adversely impact the trading price of the notes. The market price of our common stock could alsobe affected by possible sales of our common stock by investors who view the notes as a more attractive means of equity participation in us and by hedging orarbitrage trading activity that we expect to develop involving our common stock. This trading activity could, in turn, affect the trading price of the notes.We may still incur substantially more debt or take other actions which would intensify the risks discussed above.We are not restricted under the terms of the indenture governing the notes from incurring additional debt, securing existing or future debt, recapitalizing ourdebt, or taking a number of other actions that are not limited by the terms of the indenture governing the notes that could have the effect of diminishing our abilityto make payments on the notes when due. Any failure by us or any of our significant subsidiaries to make any payment at maturity of indebtedness for borrowedmoney in excess of $15 million or the acceleration of any such indebtedness in excess of $15 million would, subject to the terms of the indenture governing thenotes, constitute a default under the indenture. If the repayment of the related indebtedness were to be accelerated after any applicable notice or grace periods, wemay not have sufficient funds to repay the notes when required.We may not have the ability to raise the funds necessary to repurchase the notes upon specified dates or upon a fundamental change, and our future debtmay contain limitations on our ability to repurchase the notes.37Holders of the notes have the right to require us to repurchase all or a portion of their notes on certain dates or upon the occurrence of a fundamental changeat a repurchase price equal to 100% of the principal amount of the notes to be repurchased, plus accrued and unpaid interest, if any. We may not have enoughavailable cash or be able to obtain financing at the time we are required to make repurchases of notes surrendered therefor.In addition, our ability to repurchase the notes may be limited by law, regulatory authority, or agreements governing our future indebtedness. Our failure torepurchase notes at a time when the repurchase is required by the indenture would constitute a default under the indenture. A default under the indenture or thefundamental change itself could also lead to a default under agreements governing our future indebtedness. If the repayment of the related indebtedness were to beaccelerated after any applicable notice or grace periods, we may not have sufficient funds to repay the indebtedness and repurchase the notes when required.Holders of notes are not entitled to any rights with respect to our common stock, but they are subject to all changes made with respect to them to theextent our conversion obligation includes shares of our common stock.Holders of notes are not entitled to any rights with respect to our common stock (including, without limitation, voting rights and rights to receive anydividends or other distributions on our common stock) prior to the conversion date with respect to any notes they surrender for conversion, but they are subject toall changes affecting our common stock. For example, if an amendment is proposed to our certificate of incorporation or bylaws requiring stockholder approvaland the record date for determining the stockholders of record entitled to vote on the amendment occurs prior to the conversion date with respect to any notessurrendered for conversion, then the holder surrendering such notes will not be entitled to vote on the amendment, although such holder will nevertheless besubject to any changes affecting our common stock.We have made only limited covenants in the indenture governing the notes, and these limited covenants may not protect a noteholder's investment.The indenture governing the notes does not:•require us to maintain any financial ratios or specific levels of net worth, revenues, income, cash flows, or liquidity and, accordingly, does not protectholders of the notes in the event that we experience adverse changes in our financial condition or results of operations;•limit our subsidiaries’ ability to guarantee or incur indebtedness that would rank structurally senior to the notes;•limit our ability to incur additional indebtedness, including secured indebtedness;•restrict our subsidiaries’ ability to issue securities that would be senior to our equity interests in our subsidiaries and therefore would be structurallysenior to the notes;•restrict our ability to repurchase our securities;•restrict our ability to pledge our assets or those of our subsidiaries; or•restrict our ability to make investments or pay dividends or make other payments in respect of our common stock or our other indebtedness.Furthermore, the indenture governing the notes contains only limited protections in the event of a change of control. We could engage in many types oftransactions, such as acquisitions, refinancings, or certain recapitalizations, that could substantially affect our capital structure and the value of the notes and ourcommon stock but may not constitute a “fundamental change” that permits holders to require us to repurchase their notes or a “make-whole fundamental change”that permits holders to convert their notes at an increased conversion rate. For these reasons, the limited covenants in the indenture governing the notes may notprotect a noteholder's investment in the notes.38The increase in the conversion rate for notes converted in connection with a make-whole fundamental change or provisional redemption may notadequately compensate noteholders for any lost value of the notes as a result of such transaction or redemption.If a make-whole fundamental change occurs prior to February 6, 2021 or upon our issuance of a notice of provisional redemption, under certaincircumstances, we will increase the conversion rate by a number of additional shares of our common stock for notes converted in connection with such events. Theincrease in the conversion rate for notes converted in connection with such events may not adequately compensate noteholders for any lost value of the notes as aresult of such transaction or redemption. In addition, if the price of our common stock in the transaction is greater than $180.00 per share or less than $39.96 pershare (in each case, subject to adjustment), no additional shares will be added to the conversion rate. Moreover, in no event will the conversion rate per $1,000principal amount of notes as a result of this adjustment exceed 25.0250 shares of common stock, subject to adjustment.Our obligation to increase the conversion rate for notes converted in connection with such events could be considered a penalty, in which case theenforceability thereof would be subject to general principles of reasonableness and equitable remedies.The conversion rate of the notes may not be adjusted for all dilutive events.The conversion rate of the notes is subject to adjustment for certain events, including, but not limited to, the issuance of certain stock dividends on ourcommon stock, the issuance of certain rights or warrants, subdivisions, combinations, distributions of capital stock, indebtedness, or assets, cash dividends andcertain issuer tender or exchange offers. However, the conversion rate will not be adjusted for other events, such as a third-party tender or exchange offer or anissuance of common stock for cash, that may adversely affect the trading price of the notes or our common stock. An event that adversely affects the value of thenotes may occur, and that event may not result in an adjustment to the conversion rate.Some significant restructuring transactions may not constitute a fundamental change, in which case we would not be obligated to offer to repurchase thenotes.Upon the occurrence of a fundamental change, a holder of notes has the right to require us to repurchase the notes. However, the fundamental changeprovisions will not afford protection to holders of notes in the event of other transactions that could adversely affect the notes. For example, transactions such asleveraged recapitalizations, refinancings, restructurings, or acquisitions initiated by us may not constitute a fundamental change requiring us to repurchase thenotes. In the event of any such transaction, the holders would not have the right to require us to repurchase the notes, even though each of these transactions couldincrease the amount of our indebtedness, or otherwise adversely affect our capital structure or any credit ratings, thereby adversely affecting the holders of notes.In addition, absent the occurrence of a fundamental change or a make-whole fundamental change as described under changes in the composition of our boardof directors will not provide holders with the right to require us to repurchase the notes or to an increase in the conversion rate upon conversion.We cannot assure noteholders that an active trading market will develop or be maintained for the notes.We do not intend to apply to list our outstanding convertible notes on any securities exchange or to arrange for quotation on any automated dealer quotationsystem. In addition, the liquidity of the trading market in the notes and the market price quoted for the notes may be adversely affected by changes in the overallmarket for this type of security and by changes in our financial performance or prospects or in the prospects for companies in our industry generally. As a result,we cannot assure noteholders that an active trading market will develop or be maintained for the notes. If an active trading market does not develop or is notmaintained, the market price and liquidity of the notes may be adversely affected. In that case, noteholders may not be able to sell the notes at a particular time orat a favorable price.Any adverse rating of the notes may cause their trading price to fall.We do not intend to seek a rating on the notes. However, if a rating service were to rate the notes and if such rating service were to lower its rating on thenotes below the rating initially assigned to the notes or otherwise announces its intention to put the notes on credit watch, the trading price of the notes coulddecline.39Holders of notes may be subject to tax if we make or fail to make certain adjustments to the conversion rate of the notes even though they do not receive acorresponding cash distribution.The conversion rate of the notes is subject to adjustment in certain circumstances, including the payment of cash dividends. If the conversion rate is adjustedas a result of a distribution that is taxable to our common stockholders, such as a cash dividend, a noteholder may be deemed to have received a dividend subject toU.S. federal income tax without the receipt of any cash. In addition, a failure to adjust (or to adjust adequately) the conversion rate after an event that increases anoteholder's proportionate interest in us could be treated as a deemed taxable dividend to you. If a make-whole fundamental change occurs prior to February 6,2021 or we provide notice of a provisional redemption, under some circumstances, we will increase the conversion rate for notes converted in connection with themake-whole fundamental change or provisional redemption. Such increase may also be treated as a distribution subject to U.S. federal income tax as a dividend.For a non-U.S. holder, any deemed dividend would be subject to U.S. federal withholding tax at a 30% rate, or such lower rate as may be specified by anapplicable treaty, which may be set off against subsequent payments on the notes.Any conversions of the notes will dilute the ownership interest of our existing stockholders, including holders who had previously converted their notes.Any conversion of some or all of the notes will dilute the ownership interests of our existing stockholders. Any sales in the public market of our commonstock issuable upon such conversion could adversely affect prevailing market prices of our common stock. In addition, the existence of the notes may encourageshort selling by market participants because the conversion of the notes could depress the price of our common stock.ITEM 1B. UNRESOLVED STAFF COMMENTSNone. ITEM 2. PROPERTIESWe lease approximately 95,000 square feet of office and laboratory space at our headquarters in South San Francisco, California under a lease that expires inApril 2020. Additionally, we lease office, laboratory and manufacturing space in Singapore of approximately 52,000 square feet and in Ontario, Canada ofapproximately 44,000 square feet under leases that expire in June 2022 and March 2026, respectively. As of December 31, 2016 , we also leased office space inNorth Carolina, Japan, China, United Kingdom and France, with various expiration dates through March 2026. We believe that our existing office, laboratory, andmanufacturing space, together with additional space and facilities available on commercially reasonable terms, will be sufficient to meet our current needs through2017. In addition, we believe that our properties are in good condition and are adequate and suitable for their purposes.ITEM 3. LEGAL PROCEEDINGSOn December 21, 2015, Thermo Fisher Scientific, Inc. (“Thermo”) filed a complaint in the Circuit Court for the County of Kalamazoo of Michigan againstone of its former employees who had recently been hired by us alleging, among other claims, misappropriation of proprietary information and breach of contractualand fiduciary obligations to Thermo while still an employee of Thermo. On November 23, 2016, Thermo amended its complaint to add us as a party to thelitigation, making various commercial and employment-related claims and seeking damages and injunctive relief.Additionally, in the normal course of business, we are from time to time involved in legal proceedings or potential legal proceedings, including mattersinvolving employment, intellectual property, or others. Although the results of litigation and claims cannot be predicted with certainty, we currently believe thatthe final outcome of any currently pending matters would not have a material adverse effect on our business, operating results, financial condition, or cash flows.Regardless of the outcome, litigation can have an adverse impact on us because of defense and settlement costs, diversion of management resources, and otherfactors.ITEM 4. MINE SAFETY DISCLOSURESNot applicable.40PART II ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITYSECURITIESMarket for Our Common Stock; DividendsOur common stock began trading on the NASDAQ Global Select Market under the symbol “FLDM” on February 10, 2011. The following table sets forth therange of high and low closing sales prices of our common stock for the periods indicated: Year ended December 31, 2016 High LowFirst Quarter $10.12 $5.47Second Quarter $10.91 $8.20Third Quarter $10.72 $7.88Fourth Quarter $8.12 $4.34Year ended December 31, 2015 High LowFirst Quarter $45.54 $33.27Second Quarter $44.47 $23.39Third Quarter $23.60 $8.11Fourth Quarter $11.95 $7.38We had approximately 95 stockholders of record as of February 10, 2017; however, because many of our outstanding shares are held in accounts withbrokers and other institutions, we believe we have more beneficial owners. We have never declared or paid cash dividends on our common stock and do not expectto pay dividends on our common stock for the foreseeable future. Instead, we anticipate that all of our earnings in the foreseeable future will be used for theoperation and growth of our business.41Stock Performance GraphThe following performance graph shall not be deemed “soliciting material” or to be “filed” with the Securities and Exchange Commission for purposes ofSection 18 of the Securities Exchange Act of 1934, as amended, or the Exchange Act, or otherwise subject to the liabilities under that Section, and shall not bedeemed to be incorporated by reference into any filing of Fluidigm Corporation under the Securities Act or the Exchange Act.The following graph shows a comparison from December 31, 2011 through December 31, 2016 of the cumulative total return for our common stock, theNASDAQ Composite Total Return Index and the NASDAQ US Benchmark Medical Equipment Index, each of which assumes an initial investment of $100 andreinvestment of all dividends. Such returns are based on historical results and are not intended to suggest future performance.Sales of Unregistered SecuritiesNone.Issuer Purchases of Equity SecuritiesWe did not repurchase any shares of our common stock during the year ended December 31, 2016.42ITEM 6. SELECTED FINANCIAL DATAThe following selected financial data should be read in conjunction with the consolidated financial statements and related notes thereto appearing elsewherein this Form 10-K. We have derived the consolidated statement of operations data for the years ended December 31, 2016 , 2015 , and 2014 and consolidatedbalance sheet data as of December 31, 2016 and December 31, 2015 from audited consolidated financial statements included elsewhere in this Form 10-K. Theconsolidated statement of operations data for the years ended December 31, 2013 and December 31, 2012 and the consolidated balance sheet data as of December31, 2014, December 31, 2013 , and December 31, 2012 were derived from audited consolidated financial statements that are not included in this Form 10-K. Year Ended December 31, 2016 2015 2014 2013 2012 (in thousands, except per share amounts)Consolidated Statement of Operations Data: Total revenue $104,446 $114,712 $116,456 $71,183 $52,334Loss from operations (73,190) (50,155) (51,836) (18,653) (18,071)Net loss (75,985) (53,315) (52,830) (16,526) (19,024)Net loss per share, basic and diluted (2.62) (1.86) (1.90) (0.65) (0.86) December 31, 2016 2015 2014 2013 2012 (in thousands)Consolidated Balance Sheet Data: Cash, cash equivalents, and short and long-term investments $59,430 $101,465 $142,800 $86,286 $83,677Working capital (1) 76,334 123,433 133,440 89,354 91,500Total assets (2) 306,395 370,050 406,506 116,915 113,732Total long-term debt (2) 194,951 194,673 194,402 — —Total stockholders’ equity 53,233 114,901 150,419 96,414 100,657(1) Working capital excludes deferred revenue.(2) $1.1 million and $1.0 million of debt issuance costs of Convertible notes were previously included in Total assets reclassified to Total long-term debt as adeduction in December 31, 2014 and December 31, 2015, respectively.43ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONSThe following discussion and analysis should be read together with our consolidated financial statements and the notes to those statements includedelsewhere in this Form 10-K. This discussion contains forward-looking statements based on our current expectations, assumptions, estimates and projectionsabout Fluidigm and our industry. These forward-looking statements involve risks and uncertainties. Our actual results could differ materially from those indicatedin these forward-looking statements as a result of certain factors, as more fully described in “Risk factors” in Item 1A of this Form 10-K, in this Item 7, andelsewhere in this Form 10-K. Except as may be required by law, we undertake no obligation to update publicly any forward-looking statements for any reason,even if new information becomes available or other events occur in the future.OverviewWe create, manufacture, and market innovative technologies and tools for life sciences research. We sell instruments and consumables, including integratedfluidic circuits, or IFCs, assays and reagents, to academic institutions, clinical research laboratories, and biopharmaceutical, biotechnology, and agriculturalbiotechnology, or Ag-Bio, companies and contract research organizations or CROs. Our technologies and tools are directed at the analysis of DNA, RNA andproteins in a variety of different sample types, from individual cells to bulk tissue.We distribute our systems through our direct sales force and support organizations located in North America, Europe, and Asia-Pacific, and throughdistributors or sales agents in several European, Latin American, Middle Eastern, and Asia-Pacific countries. Our manufacturing operations are primarily located inSingapore, Canada and the United States. Our facility in Singapore manufactures our genomics instruments, several of which are assembled at facilities of ourcontract manufacturers in Singapore, with testing and calibration of the assembled products performed at our Singapore facility. All of our IFCs for commercialsale and some IFCs for our research and development purposes are also fabricated at our Singapore facility. Our Canada facility manufactures our mass cytometryinstruments. Our facility in the United States manufactures assays and reagents.Our total revenue was $104.4 million in 2016 , $114.7 million in 2015 , and $116.5 million in 2014 . We have incurred significant net losses since ourinception in 1999 and, as of December 31, 2016 , our accumulated deficit was $439.5 million .Due to our negative revenue growth in 2016 and 2015, we implemented certain operational efficiency and cost-savings initiatives beginning in the firstquarter of 2017 intended to align our resources with our product strategy, reduce our operating expenses, and manage our cash flows. These cost efficiencyinitiatives include targeted workforce reductions, optimizing our facilities, and reducing excess space. In addition, we may need to decrease or defer capitalexpenditures and development activities to further optimize our operations. Such measures may impair our ability to invest in developing, marketing and sellingnew and existing products. The efficiency and cost-savings initiatives are expected to reduce operating expenses and enable us to efficiently align our resources inareas providing the greatest benefit. If our efficiency and cost reduction efforts are unsuccessful, our cash position could be negatively impacted and we may,among other things, be required to seek other sources of financing.Critical Accounting Policies, Significant Judgments and EstimatesOur consolidated financial statements and the related notes included elsewhere in this Form 10-K are prepared in accordance with accounting principlesgenerally accepted in the United States. The preparation of these consolidated financial statements requires us to make estimates and assumptions that affect thereported amounts of assets, liabilities, revenue, costs, and expenses and related disclosures. We base our estimates on historical experience and on various otherassumptions that we believe to be reasonable under the circumstances. Changes in accounting estimates may occur from period to period. Accordingly, actualresults could differ significantly from the estimates made by our management. We evaluate our estimates and assumptions on an ongoing basis. To the extent thatthere are material differences between these estimates and actual results, our future financial statement presentation, financial condition, results of operations, andcash flows will be affected.We believe that the following critical accounting policies involve a greater degree of judgment and complexity than our other accounting policies.Accordingly, these are the policies we believe are the most critical to understanding and evaluating our consolidated financial condition and results of operations.Our accounting policies are more fully described in Note 2 of the notes to our audited consolidated financial statements.44Revenue RecognitionWe generate revenue from sales of our products and services, license agreements, and government grants. Our product revenue consists of sales ofinstruments and consumables, including IFCs, assays and reagents. Our service revenue consists of sales of post-warranty service contracts, preventivemaintenance plans, instrument parts, installation, and training.We recognize revenue when persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price to the customer isfixed or determinable, and collectability is reasonably assured. Revenue from the sales of our products that are not part of multiple element arrangements arerecognized when no significant obligation remains undelivered and collection is reasonably assured, which is generally when delivery has occurred. Deliveryoccurs when there is a transfer of title and risk of loss passes to the customer. Payments received in advance of revenue recognition are classified as deferredrevenue in the consolidated balance sheet.The evaluation of these revenue recognition criteria requires significant management judgment. For instance, we use judgment to assess collectability basedon factors such as the customer’s creditworthiness and past collection history, if applicable. If we determine that collection is not reasonably assured, revenuerecognition is deferred until receipt of payment. We also use judgment to assess whether a price is fixed or determinable by, among other things, reviewingcontractual terms and conditions related to payment.Certain of our sales contracts involve the delivery of multiple products or services within contractually binding arrangements. Multiple-deliverable salestransactions typically consist of the sale and delivery of one or more instruments and consumables together with one or more of our installation, training and/orcustomer support services. Significant judgment is sometimes required to determine the appropriate accounting for such arrangements, including whether thedeliverables specified in a multiple element arrangement should be treated as separate units of accounting for revenue recognition purposes and, if so, how therelated sales price should be allocated among the elements, when to recognize revenue for each element, and the period over which revenue should be recognized.For sales contracts that include multiple deliverables, we allocate the contract consideration at the inception of the contract to each unit of accounting basedupon their relative selling prices. We may use our best estimate of selling price for individual deliverables when vendor specific objective evidence or third-partyevidence is unavailable. A delivered item is considered to be a separate unit of accounting when it has value to the customer on a stand-alone basis.Our products are typically delivered within a short time frame, generally within one to three months, of the contract date. Service contracts are entered intofor terms of one to three years, following the expiration of the warranty period.Our products are generally sold without the right of return. Accruals are provided for estimated warranty expenses at the time the associated revenue isrecognized. We use judgment to estimate these accruals and, if we were to experience an increase in warranty claims or if costs of servicing our products underwarranty were greater than our estimates, our cost of product revenue could be adversely affected in future periods.License and royalty revenue from license agreements is recognized when received, which is generally in the quarter following the quarter in which thecorresponding sales occur.We have received grants from various governmental entities for research and related activities. Grants provide us with payments for certain types of researchand development activities performed over a contractually defined period. Grant revenue is recognized in the period during which the related costs are incurred,provided that the conditions under which the grants were provided have been met and we have only perfunctory obligations outstanding. Amounts received inadvance of revenue recognition are classified as deferred revenue in the consolidated balance sheets. Costs associated with grants are included in research anddevelopment expenses in the consolidated statements of operations.Changes in judgments and estimates regarding application of these revenue recognition guidelines as well as changes in facts and circumstances could resultin a change in the timing or amount of revenue recognized in future periods.Stock-Based CompensationWe recognize compensation for all stock-based awards, including stock options and restricted stock units, based on the grant date fair value of the award.The fair value of options on the grant date is estimated using the Black-Scholes option-pricing model, which requires the use of certain subjective assumptions,including expected term, volatility, risk-free interest rate and the fair value of our common stock. These assumptions generally require significant judgment. Stock-based45compensation cost for restricted stock units granted to employees is measured based on the closing fair market value of our common stock on the date of grant. Our board of directors sets the terms, conditions, and restrictions related to the grant of stock options and restricted stock units, including the number ofshares underlying the grants and the vesting criteria. With respect to performance-based stock awards, depending on the extent to which the vesting criteria aremet, our board of directors determines the number of shares that vest under the grants.The resulting costs of our equity awards, net of estimated forfeitures, are recognized over the period during which an employee is required to provide servicein exchange for the award, usually a time-based vesting period. We amortize the fair value of stock-based compensation on a straight-line basis over the requisiteservice periods. For performance-based stock awards, stock-based compensation expense is recognized over the requisite service period when the achievement ofeach individual performance milestone becomes probable.Our common stock has a limited trading history because our common stock was not publicly traded until our initial public offering, or IPO, in February2011. Accordingly, the expected volatility of our common stock is developed by combining data from our historical volatilities and historical volatilities ofunrelated public companies within the life sciences industry. When selecting our industry peer companies, we consider our stage of development, size, andfinancial leverage. These historical volatilities are weighted and combined to produce a single volatility factor. The risk-free interest rate is based on the U.S.Treasury yield in effect at the time of grant for zero coupon U.S. Treasury notes with maturities approximately equal to each grant’s expected life. We estimate theexpected lives of employee options using the “simplified” method as the midpoint of the expected time-to-vest and the contractual term.The calculated fair value of our stock options could change significantly if we determine that another method is more reasonable, or if another method forcalculating these input assumptions is prescribed by authoritative guidance. Higher volatility and longer expected lives result in an increase in stock-basedcompensation expense determined at the date of grant. Stock-based compensation expense affects our cost of product revenue, research and development expense,and selling, general and administrative expense.We estimate our forfeiture rate based on an analysis of our actual forfeitures and we will continue to evaluate the appropriateness of the forfeiture rate basedon actual forfeiture experience, analysis of employee turnover behavior, and other factors. Quarterly changes in the estimated forfeiture rate can have a significanteffect on reported stock-based compensation expense, as the cumulative effect of adjusting the rate is recognized in the period the forfeiture estimate is changed. Ifa revised forfeiture rate is higher than the previously estimated forfeiture rate, an adjustment is made that will result in a decrease to the stock-based compensationexpense recognized in the consolidated financial statements. If a revised forfeiture rate is lower than the previously estimated forfeiture rate, an adjustment is madethat will result in an increase to the stock-based compensation expense recognized in the consolidated financial statements. We will continue to use judgment inevaluating the expected term, volatility, and forfeiture rate related to our stock-based compensation.Historically, certain of our stock awards were granted to officers with vesting acceleration features based upon the achievement of certain performancemilestones. The timing of the attainment of these milestones affected the timing of expense recognition since we recognize compensation expense only for theportion of stock options that are expected to vest.We recorded stock-based compensation expense of $13.9 million , $16.8 million, and $20.9 million during 2016 , 2015 , and 2014 , respectively. As ofDecember 31, 2016 , we have $15.8 million of total unrecognized compensation cost related to stock-based compensation arrangements that is expected to berecognized over an average period of 2.3 years.Income TaxesWe use the asset and liability method to account for income taxes. Deferred tax assets and liabilities are recognized for the future tax consequencesattributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets andliabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recoveredor settled. Significant management judgment is required in determining our provision for income taxes, our deferred tax assets and liabilities, and any valuationallowance recorded against our deferred tax assets. Our provision for income taxes generally consists of tax expense/benefit related to current periodearnings/losses. As part of the process of preparing our consolidated financial statements, we continuously monitor the circumstances impacting the expectedrealization of our deferred tax assets for each jurisdiction. We consider all available evidence, including historical operating results in each jurisdiction,expectations and risks associated with estimates of future taxable income, and ongoing prudent and feasible tax planning strategies in assessing the need for a46valuation allowance. To the extent a deferred tax asset cannot be recognized, a valuation allowance is established to reduce our deferred tax assets to the amountthat is more likely than not to be realized. These deferred tax assets primarily consist of net operating loss carryforwards, research and development tax credits, andstock-based compensation. We intend to maintain such valuation allowance until sufficient evidence exists to support its reduction. Our deferred tax liabilitiesprimarily consist of book and tax basis differences in fixed assets and acquired identifiable intangible assets. We make estimates and judgments about our futuretaxable income that are based on assumptions that are consistent with our plans and estimates. Should the actual amounts differ from our estimates, the amount ofour valuation allowance could be materially impacted. Changes in these estimates may result in significant increases or decreases to our tax provision in a period inwhich such estimates are changed, which in turn would affect net income or loss.We recognize the financial statement effects of a tax position when it is more likely than not, based on the technical merits, that the position will be sustainedupon examination. Any interest and penalties related to uncertain tax positions will be reflected in the income tax provision.We have not provided for U.S. federal and state income taxes on any of our non-U.S. subsidiaries’ undistributed earnings as of December 31, 2016 becausesuch earnings are intended to be indefinitely reinvested. Upon distribution of such earnings in the form of dividends or otherwise, we believe there will be nomaterial U.S. federal and state income tax liability as there are sufficient amount of tax losses or other attributes. Undistributed earnings of our foreign subsidiariesamounted to approximately $2.7 million, as of December 31, 2016. If these earning were to be repatriated, approximately $46,000 of withholding taxes may bedue. However, since such subsidiaries’ earnings are permanently reinvested, no related deferred tax liabilities were accrued as of December 31, 2016.Effective January 1, 2010, we obtained approval for Pioneer Tax Status in Singapore. The Pioneer Tax Status allowed a full exemption from Singaporecorporate tax related to contract manufacturing activities through the effective period subject to the achievement of certain milestones. Effective January 1, 2015,our Pioneer Tax Status was replaced by a Development and Expansion Incentive, or DEI, which provides a reduced tax rate for qualifying income in Singaporethrough 2019, if certain milestones are met. Due to the lower mix of genomics production activities, we expect that we will not be able to fulfill the DEImilestones. Due to available capital allowances, we have not benefited from the reduced tax rate through December 31, 2016, and may not benefit from theincentive in future years if the incentive is withdrawn.Inventory ValuationWe record adjustments to inventory for potentially excess, obsolete, slow-moving, or impaired goods in order to state inventory at its net realizable value.The business environment in which we operate is subject to rapid changes in technology and customer demand. We regularly review inventory for excess andobsolete products and components, taking into account product life cycle and development plans, product expiration and quality issues, historical experience, andour current inventory levels. If actual market conditions are less favorable than anticipated, additional inventory adjustments could be required.Business CombinationsAssets acquired and liabilities assumed as part of a business acquisition are generally recorded at their fair value at the date of acquisition. The excess ofpurchase price over the fair value of assets acquired and liabilities assumed is recorded as goodwill. Determining fair value of identifiable assets, particularlyintangibles, and liabilities acquired also requires management to make estimates, which are based on all available information and in some cases assumptions withrespect to the timing and amount of future revenues and expenses associated with an asset. Accounting for business acquisitions requires management to makejudgments as to whether a purchase transaction is a multiple element contract, meaning that it includes other transaction components such as a settlement of apreexisting relationship. This judgment and determination affects the amount of consideration paid that is allocable to assets and liabilities acquired in the businesspurchase transaction.Long-lived Assets, including GoodwillGoodwill and intangible assets with indefinite lives are not subject to amortization, but are tested for impairment on an annual basis during the fourth quarteror whenever events or changes in circumstances indicate the carrying amount of these assets may not be recoverable. Screening for and assessing whetherimpairment indicators exist, or if events or changes in circumstances have occurred, including a decline in our stock price or market capitalization, declines in ourmarket shares or revenue, operating fundamentals, rapid changes in technology, competition, general economic conditions or other matters, requires significantjudgment. An impairment charge may occur as a result of future goodwill and intangible asset impairment tests. The decreases in revenue and stock price that haveoccurred and may occur in the future could make such impairment more likely to result. If impairment is deemed to exist, we would write-down the recorded valueof these intangible assets to47their fair values. If and when these write-downs occur, they could harm our results of operations. We first conduct an assessment of qualitative factors to determinewhether it is more likely than not that the fair value of our reporting unit is less than its carrying amount. If we determine that it is more likely than not that the fairvalue of our reporting unit is less than its carrying amount, we then conduct a two-step test for impairment of goodwill. In the first step, we compare the fair valueof our reporting unit to its carrying value. If the fair value of our reporting unit exceeds the carrying value of the net assets, goodwill is not considered impaired andno further analysis is required. If the carrying value of the net assets exceeds the fair value of the reporting unit, then the second step of the impairment test must beperformed in order to determine the implied fair value of the goodwill. If the carrying value of the goodwill exceeds the implied fair value, then an impairment lossequal to the difference would be recorded.We evaluate our finite lived intangible assets for indicators of possible impairment when events or changes in circumstances indicate the carrying amount ofan asset may not be recoverable. If any indicator of impairment exists, we assess the recoverability of the affected intangible assets by determining whether thecarrying value of the asset can be recovered through undiscounted future operating cash flows. If impairment is indicated, we estimate the asset’s fair value usingfuture discounted cash flows associated with the use of the asset, and adjust the carrying value of the asset accordingly.Results of OperationsThe following table presents our historical consolidated statements of operations data for the years ended December 31, 2016 , 2015 , and 2014 , and as apercentage of total revenue for the respective years (in thousands): Year Ended December 31, 2016 2015 2014Revenue: Total revenue $104,446 100 % $114,712 100 % $116,456 100 %Costs and expenses: Cost of product revenue 41,110 39 43,001 37 39,511 34Cost of service revenue 4,899 5 3,629 3 3,338 3Research and development 38,415 37 39,264 34 43,423 37Selling, general and administrative 93,212 89 82,959 72 71,324 62Acquisition-related expenses — — — — 10,696 9Gain on escrow settlement — — (3,986) (3) — —Total costs and expenses 177,636 170 164,867 143 168,292 145Loss from operations (73,190) (70) (50,155) (44) (51,836) (45)Interest expense (5,820) (6) (5,808) (4) (5,344) (4)Gain from sale of investment in Verinata — — 2,330 2 332 1Other expense, net (1,167) (1) (1,157) (1) (857) (1)Loss before income taxes (80,177) (77) (54,790) (47) (57,705) (49)Benefit from income taxes 4,192 4 1,475 1 4,875 4Net loss $(75,985) (73)% $(53,315) (46)% $(52,830) (45)%RevenueWe generate revenue primarily from sales of our products and services, license agreements, and government grants. Our product revenue consists of sales ofinstruments and consumables, including IFCs, assays and reagents. Our service revenue consists of post-warranty service contracts, preventive maintenance plans,instrument parts, installation and training. We have entered into license agreements and have received government grants to conduct research and developmentactivities.48The following table presents our revenue by source for each period presented (in thousands): Year Ended December 31, Change 2016 2015 2014 2016 2015Revenue: Instruments $46,834 $58,455 $60,233 (20)% (3)%Consumables 42,169 43,685 46,838 (3)% (7)%Product revenue 89,003 102,140 107,071 (13)% (5)%Service revenue 15,205 12,315 8,844 23 % 40 %License revenue 238 257 323 (7)% (20)%Grant revenue — — 218 — % (100)%Total revenue $104,446 $114,712 $116,456 (9)% (1)%The following table presents our total revenue by geographic area and as a percentage of total revenue by geographic area of our customers for each periodpresented (in thousands): Year Ended December 31, Change 2016 2015 2014 2016 2015United States $52,637 51% $55,404 48% $59,674 51% (5)% (7)%Europe 29,739 28% 36,772 32% 33,045 29% (19)% 11 %Asia-Pacific 18,478 18% 16,967 15% 19,810 17% 9 % (14)%Other 3,592 3% 5,569 5% 3,927 3% (36)% 42 %Total revenue $104,446 100% $114,712 100% $116,456 100% (9)% (1)%Our license and grant revenue is primarily generated in the United States.We sell our instruments to leading academic research institutions, clinical research laboratories, and biopharmaceutical, biotechnology and Ag-Biocompanies. Revenue from our five largest customers in each of the periods presented comprised 15%, 13%, and 15% of total revenue in 2016 , 2015 , and 2014 ,respectively.Total RevenueTotal revenue decrease d by $10.3 million , or 9% , to $104.4 million for 2016 , compared to $114.7 million for 2015 primarily due to a decrease of $13.1million in product revenue, partially offset by a $2.9 million increase in service revenue. Total revenue decreased in all geographic areas, except Asia-Pacific for2016 compared to 2015. The revenue decrease was predominantly in Europe due to lower instrument sales. The revenue increase in Asia-Pacific was largelyattributable to a $5.5 million, or 97%, increase in our revenue in China, offset by a reduction of sales in the rest of the region, primarily Japan, for 2016 comparedto 2015. We cannot provide any assurance that the revenue growth rate that we experienced in China in 2016 will continue.Total revenue decrease d by $1.7 million , or 1% , to $114.7 million for 2015 , compared to $116.5 million for 2014 primarily due to a decrease of $4.9million in product revenue, partially offset by a $3.5 million increase in service revenue. Unfavorable foreign exchange rates, primarily between the U.S. dollar andEuro, adversely affected total revenue from Europe by approximately $5.0 million in 2015.Due to the volatility in currency exchange rates, we have experienced and may in the future experience fluctuations in currency exchange rates which couldhave an adverse impact on our financial results in the future.Product RevenueProduct revenue decrease d by $13.1 million , or 13% , to $89.0 million for 2016 , compared to $102.1 million for 2015 . Product revenue decrease d by $4.9million , or 5% , to $102.1 million for 2015 compared to $107.1 million for 2014 .49Instrument revenue decreased by $11.6 million , or 20% , to $46.8 million for 2016 , compared to 2015, predominately due to lower unit sales across mostinstrument systems, primarily our genomic instruments and particularly our C1 systems.Instrument revenue decreased by $1.8 million , or 3% , to $58.5 million for 2015, compared to 2014, primarily due to decreases in unit sales of BioMark, C1and Access Array systems and, to a lesser extent, lower average selling prices, partially offset by growth in unit sales of Helios/CyTOF2 systems with relativelyhigher selling prices compared to genomic systems, and contributions from new products including Juno and Polaris. Changes in foreign exchange rates negativelyaffected instrument revenue by $3.6 million, or 6% in 2015 compared to 2014.Consumables revenue decreased by $1.5 million , or 3% , to $42.2 million for 2016, compared to 2015, largely attributable to decreased unit sales from IFCs,particularly Access Array IFCs, and to a lesser extent, lower average selling prices for most IFCs. The decrease was partially offset by increased sales from Heliosconsumables.Consumables revenue decreased by $3.2 million , or 7% , to $43.7 million for 2015, compared to 2014, primarily due to decreases in unit sales of IFCs, aswell as the negative effects of foreign exchange rates, which reduced consumables revenue by $2.3 million or 5% in 2015.We expect the average selling prices of our products to fluctuate over time based on market conditions, product mix, and currency fluctuations. In addition,our total revenue and product revenue declined in 2016 compared to 2015 and declined in 2015 compared to 2014, and we cannot provide assurance concerningfuture revenue growth, if any.Service RevenueService revenue increased by $2.9 million, or 23%, to $15.2 million for 2016 compared to 2015. Service revenue increased by $3.5 million, or 40%, to $12.3million for 2015 compared to 2014. The increases in both 2016 and 2015 were primarily due to an increase in instruments under post-warranty service contracts asa result of growth in our installed base. Changes in service contracts generally lag changes in our instrument revenue by one year. In addition, other fee-for-serviceofferings, including training, installation, parts, labor and preventive maintenance, increased during the periods.Grant and License RevenueGrant revenue consists of a grant from the California Institute for Regenerative Medicine (CIRM). Grant revenue was $0.2 million in 2014. There was nogrant revenue in 2015 and 2016. Our CIRM grant was awarded in 2011 in the amount of $1.9 million to be earned over a three-year period, which ended in April2014. The CIRM grant revenue was recognized as the related research and development services were performed and costs associated with the grants wererecognized as research and development expense during the period incurred.License revenue was $0.2 million in 2016 and $0.3 million for both 2015 and 2014.50Cost of Product and Service RevenueCost of product revenue includes manufacturing costs incurred in the production process, including component materials, labor and overhead, installation,packaging, and delivery costs. In addition, cost of product revenue includes amortization of developed technology and intangibles, royalty costs for licensedtechnologies included in our products, warranty, provisions for slow-moving and obsolete inventory, and stock-based compensation expense. Cost of servicerevenue includes direct labor hours, overhead and instrument parts. Costs related to license and grant revenue are included in research and development expense.The following table presents our cost of product and service revenue and product and service margins for each period presented (in thousands): Year Ended December 31, 2016 2015 2014Cost of product revenue $41,110 $43,001 $39,511Product margin 54% 58% 63%Cost of service revenue 4,899 3,629 3,338Service margin 68% 71% 62%Cost of product revenue decrease d by $1.9 million , or 4% , to $41.1 million for 2016 compared to $43.0 million for 2015 . Cost of product revenue increased by $3.5 million , or 9% , to $43.0 million for 2015 compared to $39.5 million for 2014 . Cost of product revenue includes the amortization of acquiredintangibles assets resulting from our acquisition of DVS, which was $11.2 million for both 2016 and 2015 . Cost of product revenue for 2014 includes $10.7million of amortization of developed technology and inventory fair value write-up resulting from our acquisition of DVS. Overall cost of product revenue as apercentage of product revenue was 46% for 2016 , 42% for 2015 , and 37% for 2014 , including 13%, 11% and 10%, respectively, of acquisition-relatedamortization expenses.Product margin declined 4 percentage points during 2016 compared to 2015, primarily driven by higher acquisition-related intangible amortization costs as apercentage of product revenue and, to a lesser extent, lower average selling prices for certain genomics instruments and lower consumables capacity utilization.Product margin declined 5 percentage points during 2015 compared to 2014 primarily due to lower consumables capacity utilization, lower instrument sellingprices across all instrument systems, higher acquisition-related amortization costs and higher IFC inventory reserves related to product transitions.Cost of service revenue increased by $1.3 million, or 35%, to $4.9 million for 2016, compared to $3.6 million for 2015. Cost of service revenue increased by$0.3 million, or 9%, to $3.6 million for 2015 compared to $3.3 million for 2014. Cost of service revenue as a percentage of service revenue was 32% for 2016,29% for 2015, and 38% for 2014.Service margin declined 3 percentage points during 2016 compared to 2015, mainly due to higher material and labor cost due to unfavorable product supportplan mix.Service margin increased 9 percentage points during 2015 compared to 2014, mainly due to increased post-warranty service contract revenue combined withrelatively lower growth in service costs.Operating Expenses51The following table presents our operating expenses for each period presented (in thousands): Year Ended December 31, 2016 vs. 2015change 2015 vs. 2014change 2016 2015 2014 Research and development $38,415 $39,264 $43,423 (2)% (10)%Selling, general and administrative 93,212 82,959 71,324 12 % 16 %Acquisition-related expenses — — 10,696 100 % — %Gain on escrow settlement — (3,986) — — % 100 %Total operating expenses $131,627 $118,237 $125,443 Research and DevelopmentResearch and development expense consists primarily of personnel and independent contractor costs, prototype and material expenses and other allocatedfacilities, and information technology expenses. We have made substantial investments in research and development since our inception. Our research anddevelopment efforts have focused primarily on enhancing our technologies and supporting development and commercialization of new and existing products andservices.Research and development expense decreased by $0.8 million , or 2% , to $38.4 million for 2016 compared to $39.3 million for 2015. Research anddevelopment expense decreased by $4.2 million , or 10%, to $39.3 million for 2015 compared to $43.4 million for 2014 . The decrease in research anddevelopment expense for 2016 was primarily due to a decrease in product materials and supplies of $1.8 million resulting from higher cost projects in the prioryear, including investments in our Imaging Mass Cytometry system. The decrease was partially offset by an increase in headcount and compensation related costsof $1.0 million. The decrease in research and development expense for 2015 was primarily due to a decrease in stock-based compensation expenses of $5.6 millionresulting from the vesting in 2014 of a substantial portion of equity awards in connection with the DVS acquisition according to the vesting terms, partially offsetby an increase in compensation related costs of $0.7 million and an increase in facilities costs of $0.6 million.We expect research and development expense to continue to decrease in 2017 as we implement efficiency and cost savings initiatives.Selling, General and AdministrativeSelling, general and administrative expense consists primarily of personnel costs for our sales and marketing, business development, finance, legal, humanresources and general management, as well as professional services, such as legal and accounting services.Selling, general and administrative expense increase d by $10.3 million , or 12% , to $93.2 million for 2016 compared to $83.0 million for 2015 . Selling,general and administrative expense increase d by $11.6 million , or 16% , to $83.0 million for 2015 compared to $71.3 million for 2014 . The increase for 2016was primarily due to higher headcount and compensation-related costs of $9.7 million and an increase in legal and outside services costs of $1.7 million. Theincrease was partially offset by a decrease in trade shows and marketing costs of $1.1 million. The increase for 2015 was primarily due to higher headcount andcompensation-related costs of $4.1 million, including an increase of $1.3 million in stock-based compensation; increased legal costs of $3.0 million and otheroutside services costs of $2.2 million, and increased facilities costs of $1.1 million. The increase in selling, general and administrative expense in both 2016 and2015 was mainly driven by investments in our global commercial infrastructure.We expect selling, general and administrative expense to decrease in 2017 as we implement efficiency and cost savings initiatives.Acquisition-Related ExpensesAcquisition-related expenses were $10.7 million for 2014 and primarily included accelerated vesting of certain DVS restricted stock and options, andconsulting, legal, and investment banking fees relating to our acquisition of DVS. There were no acquisition-related expenses in 2015 and 2016.52Gain on Escrow SettlementApproximately 885,000 shares of Fluidigm common stock were deposited into escrow, or Escrowed Shares, in connection with our acquisition of DVS inFebruary 2014. The Escrowed Shares comprised a portion of the merger consideration and were being held in escrow to secure indemnification obligations underthe merger agreement. Under the terms of the merger agreement, fifty percent (50.0%) of the aggregate shares subject to the indemnification escrow were eligiblefor release on March 13, 2015, or the Initial Release Date, and the balance of the shares were eligible for release on August 13, 2015, provided that in each caseshares would have continued to be held in escrow in amounts that we reasonably determined in good faith to be necessary to satisfy any claims for which we haddelivered a notice of claim which had not been fully resolved between us and the representative of the former stockholders of DVS, or Stockholder Representative.Prior to the Initial Release Date, we submitted escrow claim notices under the terms of the merger agreement, which were objected to by the StockholderRepresentative. In July 2015, we entered into a settlement agreement with the Stockholder Representative regarding the claims pursuant to which the parties agreedto release approximately 80% of the Escrowed Shares to the former stockholders of DVS, and the remaining approximately 20% of the Escrowed Shares, or170,107 shares, to us, which were canceled and returned to the status of authorized and unissued shares. On the settlement date, the 170,107 shares had a value ofapproximately $4.0 million, which was recorded to gain on escrow settlement during the quarter ended September 30, 2015.Interest Expense and Other Income and Expense, NetThe following table presents these items for each period presented (in thousands): Year Ended December 31, 2016 2015 2014Interest expense $(5,820) $(5,808) $(5,344)Gain from sale of investment in Verinata — 2,330 332Other income (expense), net (1,167) (1,157) (857)Total $(6,987) $(4,635) $(5,869)On February 4, 2014, we closed an underwritten public offering of $201.3 million aggregate principal amount of our 2.75% Senior Convertible Notes due 2034, orthe Notes. The Notes accrue interest at a rate of 2.75% per year, payable semi-annually in arrears on February 1 and August 1 of each year, commencing August 1,2014. The Notes will mature on February 1, 2034, unless earlier converted, redeemed, or repurchased in accordance with the terms of the Notes.Interest expense was $5.8 million for both 2016 and 2015 .Interest expense increase d to $5.8 million for 2015 , compared to $5.3 million for 2014 due to the accrual of interest under the terms of the Note, ascompared to a partial comparable period in 2014.Gain from Sale of Investment in VerinataIn February 2013, Illumina, Inc. acquired Verinata Health, Inc. (Verinata) for $350 million in cash and up to an additional $100 million in milestonepayments through December 2015. In March 2013, we received cash proceeds of $3.1 million in exchange for our ownership interest in Verinata, resulting in again of $1.8 million. During 2014, we received cash proceeds of $0.3 million from the escrow account related to the acquisition. We recorded these amounts as"Gain from sale of investment in Verinata" in the accompanying consolidated statements of operations for the years ended December 31, 2013 and 2014. The finalmilestones related to the sale of Verinata to Illumina were met in December 2015 and, accordingly, we recorded our share of these milestone payment obligationsin the amount of $2.3 million in Other Assets and Gain from sale of investment in Verinata in the accompanying consolidated statement of operations for the yearended December 31, 2015. In January 2016, we received payment of this amount.Other expense, net was $1.2 million for both 2016 and 2015 and $0.9 million for 2014. The expense was mainly associated with losses from revaluation ofcertain foreign currency denominated assets and liabilities.53Benefit from Income TaxesWe recorded a tax benefit of $4.2 million , or an effective tax rate benefit of 5.2% , for the year ended December 31, 2016. This tax benefit was primarilyattributable to amortization of our acquisition-related deferred tax liability, net income tax benefit from our foreign operations and release of unrecognized taxbenefits. We recorded a tax benefit of $1.5 million, or an effective tax rate benefit of 2.6%, for the year ended December 31, 2015. The tax benefit was principallydue to the amortization of our acquisition-related deferred tax liability, partially offset by net income tax expense from our foreign operations and unrecognized taxbenefits.We recorded a tax benefit of $4.9 million for the year ended December 31, 2014, which was primarily attributable to the amortization of our acquisition-related deferred tax liability and net income tax benefit from our foreign operations and release of valuation allowance on California deferred tax assets, as a resultof the deferred tax liability related to its acquired intellectual propertyLiquidity and Capital ResourcesSources of LiquidityAs of December 31, 2016 , our principal sources of liquidity consisted of $35.0 million of cash and cash equivalents and $24.4 million of short-term andlong-term investments. As of December 31, 2016 , our working capital (excluding deferred revenue) totaled $76.3 million .The following table presents our cash flow summary for each period presented (in thousands): Year Ended December 31, 2016 2015 2014Cash flow summary: Net cash used in operating activities $(39,098) $(34,696) $(22,623)Net cash provided by (used in) investing activities 45,102 25,744 (178,385)Net cash provided by financing activities 76 5,303 200,326Net increase (decrease) in cash and cash equivalents 5,928 (4,596) (1,548)Net Cash Used in Operating ActivitiesWe derive cash flows from operations primarily from cash collected from the sale of our products and services, license agreements, and grants from certaingovernment entities. Our cash flows from operating activities are also significantly influenced by our use of cash for operating expenses and working capital tosupport the business. We have historically experienced negative cash flows from operating activities as we have expanded our business and built our infrastructuredomestically and internationally, and this may continue in the future.Net cash used in operating activities was $39.1 million , $34.7 million , and $22.6 million in 2016 , 2015 , and 2014 , respectively. Net cash used in operatingactivities in 2016 of $39.1 million consisted of net loss of $76.0 million less non-cash adjustments of $32.1 million , plus net change in assets and liabilities of $4.8million . Non-cash items primarily included stock-based compensation expense of $13.9 million, amortization of developed technology of $11.2 million, anddepreciation and amortization of $6.7 million. The net change in assets and liabilities was primarily driven by a decrease in accounts receivable, offset by anincrease in inventory and a decrease in accounts payable.Net cash used in operating activities in 2015 of $34.7 million consisted of net loss of $53.3 million less non-cash adjustments of $26.9 million, plus netchange in assets and liabilities of $8.2 million. Non-cash items primarily included stock-based compensation expense of $16.8 million, amortization of developedtechnology of $11.2 million, and depreciation and amortization of $4.9 million, partially offset by a $4.0 million gain on escrow settlement and $2.3 million gainfrom the sale of investment in Verinata. The net change in assets and liabilities was primarily driven by an increase in inventory and accounts receivable, offset bya net decrease in liabilities.Net cash used in operating activities during 2014 resulted from a net loss of $52.8 million, adjusted for $38.1 million in non-cash adjustments and a $7.8million increase in net assets and liabilities. Significant non-cash items included stock-based compensation expense of $20.9 million, amortization of developedtechnology of $9.8 million, depreciation and amortization of54$4.1 million, and acquisition-related share-based awards acceleration expense of $2.6 million. The net change in assets and liabilities was driven primarily byhigher inventory and accounts receivables offset by a net increase in operating liabilities. Cash used in operating activities in 2014 included $8.0 million of cashoutflows related to the DVS acquisition.Net Cash Provided by (Used in) Investing ActivitiesOur primary investing activities consist of purchases, sales, and maturities of our short-term and long-term investments and to a much lesser extent, capitalexpenditures for manufacturing, laboratory, computer equipment and software to support our infrastructure and work force. We expect to continue to incur costsfor capital expenditures for demonstration units and loaner equipment to support our sales and service efforts, and computer equipment and software to support ourbusiness operations. However, as a result of our efficiency and cost-savings initiatives, we may decrease or defer certain capital expenditures and developmentactivities, while further optimizing our organization.Net cash provided by (used in) investing activities was $45.1 million, $25.7 million and ($178.4) million in 2016, 2015, and 2014, respectively. Net cashprovided by investing activities in 2016, included proceeds from sales and maturities of investments of $86.4 million and proceeds from the sale of investment inVerinata of $2.3 million, offset by purchases of investments of $38.6 million and capital expenditures of $5.1 million to support our commercial and manufacturingoperations.Net cash provided by investing activities in 2015, included proceeds from sales and maturities of investments of $103.3 million, offset by purchases ofinvestments of $67.0 million, purchase of patents from PerkinElmer and other intangibles of $6.7 million; and capital expenditures of $4.0 million to supportgrowth in our commercial and manufacturing operations.We used $178.4 million of cash in investing activities during 2014, including $113.2 million in connection with the DVS acquisition, net of acquired cash of$8.4 million classified as cash used in operating activities, purchases of investments of $132.6 million, and capital expenditures of $7.4 million primarily to supportgrowth in our manufacturing operations; partially offset by proceeds from sales and maturities of investments of $74.5 million, and additional proceeds of $0.3million from the 2013 sale of our investment in Verinata.Net Cash Provided by Financing ActivitiesWe generated cash from financing activities of $0.1 million during 2016 and $5.3 million during 2015 from proceeds received in connection with theexercise of options for our common stock.Net cash provided by financing activities was $200.3 million during 2014, consisting of net proceeds of $195.2 million from the issuance of the Notes, and$5.1 million from proceeds received in connection with the exercise of options for our common stock.Capital ResourcesAt December 31, 2016 and December 31, 2015 , our working capital, excluding deferred revenues, was $76.3 million and $123.4 million , respectively,including cash and cash equivalents of $35.0 million and $29.1 million , respectively, and short-term and long-term investments of $24.4 million and $72.3 million, respectively. On February 4, 2014, we closed an underwritten public offering of approximately $201.3 million aggregate principal amount of our Notes andreceived cash proceeds of $195.2 million, net of underwriting discounts. Debt issuance costs were approximately $1.1 million. We used $113.2 million of the netproceeds to fund the cash portion of the consideration paid by us in connection with our acquisition of DVS.We believe our existing cash, cash equivalents, and investments will be sufficient to meet our working capital and capital expenditure needs for at least thenext 18 months. However, we may experience lower than expected cash generated from operating activities or greater than expected capital expenditures, cost ofrevenue, or operating expenses, and we may need to raise additional capital to fund our operations, further our research and development activities, or acquire orinvest in a business. Our future funding requirements will depend on many factors, including market acceptance of our products, the cost of our research anddevelopment activities, the cost of filing and prosecuting patent applications, the cost associated with litigation or disputes relating to intellectual property rights orotherwise, the cost and timing of regulatory clearances or approvals, if any, the cost and timing of establishing additional sales, marketing, and distributioncapabilities, the cost and timing of establishing additional technical support capabilities, the effect of competing technological and market developments, and theeffectiveness of our efficiency and cost reduction initiatives. In the future, we may acquire businesses or technologies from third parties, and we may decide toraise additional capital through debt or equity financing to the extent we believe this is necessary to successfully complete these acquisitions.55If we require additional funds in the future, we may not be able to obtain such funds on acceptable terms, or at all. If we raise additional funds by issuingequity securities, our stockholders may experience dilution. Debt financing, if available, may involve covenants restricting our operations or our ability to incuradditional debt. Any debt or additional equity financing that we raise may contain terms that are not favorable to us or our stockholders. If we do not have, or arenot able to obtain, sufficient funds, we may have to delay development or commercialization of our products or license to third parties the rights to commercializeproducts or technologies that we would otherwise seek to commercialize. We also may have to reduce marketing, customer support, research and development, orother resources devoted to our products.Due to our negative revenue growth in 2016 and 2015, we implemented certain operational efficiency and cost-savings initiatives beginning in the firstquarter of 2017 intended to align our resources with our product strategy, reduce our operating expenses, and manage our cash flows. These cost efficiencyinitiatives include targeted workforce reductions, optimizing our facilities, and reducing excess space. In addition, we may need to decrease or defer capitalexpenditures and development activities to further optimize our operations; such measures may impair our ability to invest in developing, marketing and sellingnew and existing products. The efficiency and cost-savings initiatives are expected to reduce operating expenses by approximately $8 million in 2017 beforeseverances expense, and to enable us to more efficiently align our resources in areas providing the greatest benefit. If our efficiency and cost reduction efforts areunsuccessful, our cash position could be negatively impacted and we may, among other things, be required to seek other sources of financing.Off-Balance Sheet ArrangementsSince our inception, we have not had any off-balance sheet arrangements as defined in Item 303(a)(4) of the Securities and Exchange Commission’sRegulation S-K.Contractual Obligations and CommitmentsThe following summarizes our contractual obligations as of December 31, 2016 (in thousands): Payments Due by Period Total Less than 1Year 1-3 Years 3-5 Years ThereafterLong term debt obligations $295,796 $5,534 $11,069 $11,069 $268,124Operating lease obligations 20,033 4,285 9,2143,929 2,605Purchase obligations 4,182 4,177 5 — —Total $320,011 $13,996 $20,288 $14,998 $270,729Debt obligations include the principal amount of the Notes and interest payments to be made under the Notes. Although the Notes mature in 2034, they canbe converted into cash and shares of our common stock prior to maturity if certain conditions are met. See Note 7 to our consolidated financial statements foradditional information regarding the terms of the Notes.Our operating lease obligations relate to a lease for our current headquarters and leases for manufacturing and office space for our foreign subsidiaries.Purchase obligations consist of contractual and legally binding commitments to purchase goods and services.We lease facilities and equipment under non-cancelable lease agreements expiring at various times through 2026. Our lease payments are expensed on astraight-line basis over the life of the leases. Rental expense under operating leases, net of amortization of lease incentive, totaled $6.3 million, $5.2 million, and$4.0 million for 2016, 2015, and 2014, respectively.We have entered into several license and patent agreements. Under these agreements, we pay annual license maintenance fees, nonrefundable licenseissuance fees, and royalties as a percentage of net sales for the sale or sublicense of products using the licensed technology. Future payments related to theselicense agreements have not been included in the contractual obligations table above as the period of time over which the future license payments will be requiredto be made, and the amount of such payments, are indeterminable. We do not expect the license payments to be material in any particular year.56ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISKMarket risk represents the risk of loss that may impact our financial position due to adverse changes in financial market prices and rates. Our market riskexposure is primarily a result of fluctuations in foreign currency exchange rates and interest rates. We do not hold or issue financial instruments for tradingpurposes.Foreign Currency Exchange RiskAs we expand internationally our results of operations and cash flows will become increasingly subject to fluctuations due to changes in foreign currencyexchange rates. Our revenue is generally denominated in the local currency of the contracting party. Historically, the majority of our revenue has been denominatedin U.S. dollars. Our expenses are generally denominated in the currencies in which our operations are located, which is primarily in the United States, with aportion of expenses incurred in Singapore and Canada where our manufacturing facilities are located. Our results of operations and cash flows are, therefore,subject to fluctuations due to changes in foreign currency exchange rates. The volatility of exchange rates depends on many factors that we cannot forecast withreliable accuracy. We have experienced and will continue to experience fluctuations in our net income or loss as a result of transaction gains or losses related torevaluing certain current asset and current liability balances that are denominated in currencies other than the functional currency of the entities in which they arerecorded. For the years ended December 31, 2016 and 2015 , we experienced foreign currency losses of $1.5 million and $1.6 million, respectively. To date, wehave not entered into any foreign currency hedging contracts although we may do so in the future. As our international operations grow, we will continue toreassess our approach to manage our risk relating to fluctuations in currency rates. If foreign currency exchange rates had changed by 10% during the periodspresented, it would not have had a material impact on our financial position or results of operations.Interest Rate SensitivityWe had cash and cash equivalents of $35.0 million at December 31, 2016 . These amounts were held primarily in cash on deposit with banks and moneymarket funds which are short-term. We had $24.4 million in investments at December 31, 2016 held primarily in U.S. government agency securities. Thecontractual maturity periods of $24.4 million of our investments are within one year from December 31, 2016 . Cash and cash equivalents and investments are heldfor working capital purposes. Due to the short-term nature of these investments, we believe that we do not have any material exposure to changes in the fair valueof our investment portfolio as a result of changes in interest rates. Declines in interest rates, however, will reduce future investment income. If overall interest rateshad decreased by 10% during the periods presented, our interest income would not have been materially affected.Fair Value of Financial InstrumentsWe do not have material exposure to market risk with respect to investments. We do not use derivative financial instruments for speculative or tradingpurposes. We may adopt specific hedging strategies in the future.57ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATAIndex to Consolidated Financial Statements PageReport of PricewaterhouseCoopers - Independent Registered Public Accounting Firm59 Report of Ernst & Young - Independent Registered Public Accounting Firm60 Consolidated Balance Sheets61 Consolidated Statements of Operations62 Consolidated Statements of Comprehensive Loss63 Consolidated Statements of Stockholders' Equity64 Consolidated Statements of Cash Flows65 Notes to Consolidated Financial Statements6658Report of Independent Registered Public Accounting FirmTo the Board of Directors andStockholders of Fluidigm Corporation:In our opinion, the accompanying consolidated balance sheets and the related consolidated statements of operations, of comprehensive loss, of stockholders’equity, and of cash flows present fairly, in all material respects, the financial position of Fluidigm Corporation and its subsidiaries at December 31, 2016, andDecember 31, 2015, and the results of their operations and their cash flows for each of the two years in the period ended December 31, 2016 in conformity withaccounting principles generally accepted in the United States of America. In addition, in our opinion, the financial statement schedule listed in the accompanyingindex appearing under Item 15(2) presents fairly, in all material respects, the information set forth therein when read in conjunction with the related consolidatedfinancial statements. Also in our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31,2016, based on criteria established in Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the TreadwayCommission (COSO). The Company's management is responsible for these financial statements and financial statement schedule, for maintaining effective internalcontrol over financial reporting and for its assessment of the effectiveness of internal control over financial reporting, included in the accompanying Management'sReport on Internal Control Over Financial Reporting. Our responsibility is to express opinions on these financial statements, on the financial statement schedule,and on the Company's internal control over financial reporting based on our integrated audits. We conducted our audits in accordance with the standards of thePublic Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audits to obtain reasonable assurance aboutwhether the financial statements are free of material misstatement and whether effective internal control over financial reporting was maintained in all materialrespects. Our audits of the financial statements included examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements,assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. Our audit ofinternal control over financial reporting included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weaknessexists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audits also included performing suchother procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinions.As discussed in Note 2 to the consolidated financial statements, the Company changed the manner in which it classifies deferred tax assets and liabilities in 2016due to the adoption of Accounting Standards Update 2015-17, Balance Sheet Classification of Deferred Taxes.A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and thepreparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financialreporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactionsand dispositions of the assets of the company; (ii) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financialstatements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance withauthorizations of management and directors of the company; and (iii) provide reasonable assurance regarding prevention or timely detection of unauthorizedacquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation ofeffectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance withthe policies or procedures may deteriorate./s/ PricewaterhouseCoopers LLPSan Jose, CaliforniaMarch 2, 201759Report of Independent Registered Public Accounting FirmThe Board of Directors and Stockholders of Fluidigm CorporationWe have audited the consolidated balance sheet of Fluidigm Corporation as of December 31, 2014, and the related consolidated statements of operations,comprehensive loss, stockholders’ equity, and cash flows for the year then ended. Our audit also included the financial statement schedule listed in the Index atItem 15(2). These financial statements and schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on thesefinancial statements and schedule based on our audit.We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require thatwe plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includesexamining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principlesused and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides areasonable basis for our opinion.In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Fluidigm Corporationat December 31, 2014, and the consolidated results of its operations and its cash flows for the year then ended, in conformity with U.S. generally acceptedaccounting principles. Also, in our opinion, the related financial statement schedule, when considered in relation to the basic financial statements taken as a whole,presents fairly in all material respects the information set forth therein./s/ Ernst & Young LLP Redwood City, CaliforniaFebruary 29, 201660FLUIDIGM CORPORATIONCONSOLIDATED BALANCE SHEETS(In thousands, except per share amounts) December 31, 2016 2015ASSETS Current assets: Cash and cash equivalents $35,045 $29,117Short-term investments 24,385 65,855Accounts receivable (net of allowances of $502 and $103 at December 31, 2016 and 2015, respectively) 14,610 25,457Inventories 20,114 17,924Prepaid expenses and other current assets 2,517 5,742Total current assets 96,671 144,095Long-term investments — 6,493Property and equipment, net 16,525 15,258Other non-current assets 9,291 9,096Developed technology, net 79,800 91,000Goodwill 104,108 104,108Total assets $306,395 $370,050LIABILITIES AND STOCKHOLDERS’ EQUITY Current liabilities: Accounts payable $3,967 $6,094Accrued compensation and related benefits 3,996 3,553Other accrued liabilities 12,374 11,015Deferred revenue, current 9,163 9,419Total current liabilities 29,500 30,081Convertible notes, net 194,951 194,673Deferred tax liability 21,140 23,595Deferred revenue, non-current 4,315 4,398Other non-current liabilities 3,256 2,402Total liabilities 253,162 255,149Commitments and contingencies Stockholders’ equity: Preferred stock, $0.001 par value, 10,000 shares authorized, no shares issued and outstanding at eitherDecember 31, 2016 or 2015 — —Common stock: $0.001 par value, 200,000 shares authorized at December 31, 2016 and 2015; 29,208 and28,844 shares issued and outstanding at December 31, 2016 and 2015, respectively 29 29Additional paid-in capital 493,441 479,508Accumulated other comprehensive loss (760) (1,144)Accumulated deficit (439,477) (363,492)Total stockholders’ equity 53,233 114,901Total liabilities and stockholders’ equity $306,395 $370,050See accompanying notes61FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF OPERATIONS(In thousands, except per share amounts) Year Ended December 31, 2016 2015 2014Revenue: Product revenue $89,003 $102,140 $107,071Service revenue 15,205 12,315 8,844License revenue 238 257 323Grant revenue — — 218Total revenue 104,446 114,712 116,456Costs and expenses: Cost of product revenue 41,110 43,001 39,511Cost of service revenue 4,899 3,629 3,338Research and development 38,415 39,264 43,423Selling, general and administrative 93,212 82,959 71,324Acquisition-related expenses — — 10,696Gain on escrow settlement — (3,986) —Total costs and expenses 177,636 164,867 168,292Loss from operations (73,190) (50,155) (51,836)Interest expense (5,820) (5,808) (5,344)Gain from sale of investment in Verinata — 2,330 332Other expense, net (1,167) (1,157) (857)Loss before income taxes (80,177) (54,790) (57,705)Benefit from income taxes 4,192 1,475 4,875Net loss (75,985) (53,315) (52,830)Net loss per share, basic and diluted $(2.62) $(1.86) $(1.90)Shares used in computing net loss per share, basic and diluted 29,008 28,711 27,768See accompanying notes62FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS(In thousands) Year Ended December 31, 2016 2015 2014Net loss $(75,985) $(53,315) $(52,830)Other comprehensive (loss) income, net of tax Foreign currency translation adjustment 314 (327) (2)Unrealized gain (loss) on available-for-sale securities, net 70 (23) (62)Other comprehensive income (loss) 384 (350) (64)Comprehensive loss $(75,601) $(53,665) $(52,894)See accompanying notes63FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY(In thousands) Common Stock AdditionalPaid-inCapital AccumulatedOtherComprehensiveLoss AccumulatedDeficit TotalStockholders’Equity Shares Amount Balance at December 31, 2013 25,811 $26 $354,465 $(730) $(257,347) $96,414Issuance of common stock upon purchase ofDVS 1,945 2 76,805 — — 76,807Vested DVS stock options converted toequivalent vested options — — 4,039 — — 4,039Issuance of common stock upon exercise ofstock options for cash and release of restrictedstock units 585 — 5,113 — — 5,113Stock-based compensation expense — — 20,940 — — 20,940Net loss — — — — (52,830) (52,830)Other comprehensive loss — — — (64) — (64)Balance at December 31, 2014 28,341 $28 $461,362 $(794) $(310,177) $150,419Issuance of common stock upon exercise ofstock options for cash and release of restrictedstock units 673 1 5,302 — — 5,303Gain on escrow settlement (170) — (3,986) — — (3,986)Stock-based compensation expense — — 16,830 — — 16,830Net loss — — — — (53,315) (53,315)Other comprehensive loss — — — (350) — (350)Balance at December 31, 2015 28,844 $29 $479,508 $(1,144) $(363,492) $114,901Issuance of common stock upon exercise ofstock options for cash and release of restrictedstock units 364 — 75 — — 75Stock-based compensation expense — — 13,858 — — 13,858Gain on escrow settlement — — — —Net loss — — — — (75,985) (75,985)Other comprehensive income — — — 384 — 384Balance at December 31, 2016 29,208 $29 $493,441 $(760) $(439,477) $53,233See accompanying notes.64FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF CASH FLOWS(In thousands) Year Ended December 31, 2016 2015 2014Operating activities Net loss $(75,985) $(53,315) $(52,830)Adjustments to reconcile net loss to net cash used in operating activities: Depreciation and amortization 6,738 4,915 4,061Stock-based compensation expense 13,858 16,830 20,940Acquisition-related share-based awards acceleration expense — — 2,648Amortization of developed technology 11,200 11,200 9,800Non-cash charges for sale of inventory revalued at the date of acquisition — — 856Other non-cash items 252 137 —Loss on disposal of property and equipment 87 87 83Gain from escrow settlement — (3,986) —Gain from sale of investment in Verinata — (2,330) (332)Changes in assets and liabilities: Accounts receivable 10,521 (2,762) (3,393)Inventories (3,387) (3,741) (6,162)Prepaid expenses and other assets (457) (1,127) (52)Accounts payable (2,271) 769 107Deferred revenue (274) 2,613 3,191Other liabilities 620 (3,986) (1,540)Net cash used in operating activities (39,098) (34,696) (22,623)Investing activities Acquisition, net of cash acquired — — (113,190)Purchases of investments (38,594) (66,973) (132,644)Proceeds from sales and maturities of investments 86,431 103,369 74,520Proceeds from sale of investment in Verinata 2,330 — 332Purchase of intangible assets — (6,670) —Purchases of property and equipment (5,065) (3,982) (7,403)Net cash provided by (used in) investing activities 45,102 25,744 (178,385)Financing activities Proceeds from issuance of convertible notes, net — — 195,213Proceeds from issuance of common stock through stock plan, net of tax payment 76 5,303 5,113Net cash provided by financing activities 76 5,303 200,326Effect of foreign exchange rate fluctuations on cash and cash equivalents (152) (947) (866)Net increase (decrease) in cash and cash equivalents 5,928 (4,596) (1,548)Cash and cash equivalents at beginning of period 29,117 33,713 35,261Cash and cash equivalents at end of period $35,045 $29,117 $33,713Supplemental disclosures of cash flow information Cash paid for interest $5,534 $5,538 $2,750Cash paid for income taxes $355 $189 $187Non-cash investing and financing activities Issuance of common stock and options related to acquisition $— $— $78,196See accompanying notes651. Description of BusinessFluidigm Corporation (we, our, or us) was incorporated in the State of California in May 1999 to commercialize microfluidic technology initially developedat the California Institute of Technology. In July 2007, we were reincorporated in Delaware. Our headquarters are located in South San Francisco, California.We create, manufacture, and market innovative technologies and tools for life sciences research. We sell our instruments to leading academic researchinstitutions, clinical research laboratories, and biopharmaceutical, biotechnology and agricultural biotechnology, or Ag-Bio companies. Our technologies and toolsare directed at the analysis of DNA, RNA and proteins in a variety of different sample types, from individual cells to bulk tissue.On February 13, 2014, we completed our acquisition of DVS Sciences, Inc., a Delaware corporation (DVS) for approximately $199.9 million and assumedall outstanding DVS stock options and unvested restricted stock, pursuant to a merger agreement dated as of January 28, 2014.2. Summary of Significant Accounting PoliciesBasis of Presentation and ConsolidationThe accompanying consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles (U.S. GAAP) andinclude the accounts of our wholly-owned subsidiaries. As of December 31, 2016, we had wholly-owned subsidiaries in Singapore, Canada, the Netherlands,Japan, France, the United Kingdom, China, and Germany. All subsidiaries, except for Singapore, use their local currency as their functional currency. TheSingapore subsidiary uses the U.S. dollar as its functional currency. All intercompany transactions and balances have been eliminated in consolidation.Prior Period ReclassificationsPrior period amounts, which do not affect total revenue, total costs and expenses, loss from operations or net loss, were reclassified to conform to the currentperiod presentation as follows:•Unamortized debt issuance costs of $1.0 million as of December 31, 2015 were reclassified from other non-current assets to a deduction from ConvertibleNotes, net in the consolidated balance sheets, as a result of adopting ASU 2015-03 in the first quarter of 2016; and•Revenue from customers in Japan is included in revenue generated in Asia-Pacific.Use of EstimatesThe preparation of financial statements in accordance with U.S. GAAP requires management to make estimates and assumptions that affect the amountsreported in the consolidated financial statements and accompanying notes. We base our estimates on historical experience and on various other assumptionsbelieved to be reasonable, which together form the basis for making judgments about the carrying values of assets and liabilities. Actual results could differmaterially from these estimates and could have a material adverse effect on our consolidated financial statements.Foreign CurrencyAssets and liabilities of non-U.S. subsidiaries that use the local currency as their functional currency are translated into U.S. dollars at exchange rates ineffect on the balance sheet date. The adjustments resulting from the foreign currency translations are recorded in accumulated other comprehensive income/loss, aseparate component of stockholders’ equity. Income and expense accounts are translated at monthly average exchange rates during the year.66Cash and Cash EquivalentsWe consider all highly liquid financial instruments with maturities at the time of purchase of three months or less to be cash equivalents. Cash and cashequivalents may consist of cash on deposit with banks, money market funds, and notes from government-sponsored agencies.InvestmentsShort and long-term investments are comprised of notes from government-sponsored agencies. All investments are recorded at estimated fair value. Anyunrealized gains and losses from investments are reported in accumulated other comprehensive loss, a separate component of stockholders’ equity. We evaluateour investments to assess whether investments with unrealized loss positions are other-than-temporarily impaired. An investment is considered to be other-than-temporarily impaired if the impairment is related to deterioration in credit risk or if it is likely that we will sell the securities before the recovery of their cost basis.No investment has been assessed as other than temporarily impaired, and realized gains and losses were immaterial during the years presented. The cost ofsecurities sold or the amount reclassified out of accumulated other comprehensive income into earnings is based on the specific-identification method.Fair Value of Financial InstrumentsOur financial instruments consist primarily of cash and cash equivalents, investments, accounts receivable, accounts payable, and convertible notes. Our cashequivalents, investments, accounts receivable, and accounts payable have short maturity or payment periods. Accordingly, their carrying values approximated theirfair values at December 31, 2016 and 2015 . The convertible notes are presented at their carrying value, with fair value disclosures made in Note 5. As a basis forconsidering fair value, we follow a three-tier value hierarchy, which prioritizes the inputs used in measuring fair value as follows:Level I: observable inputs such as quoted prices in active markets;Level II: inputs other than quoted prices in active markets that are observable either directly or indirectly; andLevel III: unobservable inputs for which there is little or no market data, which requires us to develop our own assumptions.This hierarchy requires us to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value. Ourcash equivalents, which include money market funds, are classified as Level I because they are valued using quoted market prices. Our investments and convertiblenotes are generally classified as Level II because their value is based on valuations using significant inputs derived from or corroborated by observable marketdata. Depending on the security, the income and market approaches are used in the model driven valuations. Inputs of these models include recently executedtransaction prices in securities of the issuer or comparable issuers and yield curves.Accounts ReceivableTrade accounts receivable are recorded at net invoice value. We review our exposure to accounts receivable and provide allowances of specific amounts ifcollectability is no longer reasonably assured based on historical experience and specific customer collection issues. We evaluate such allowances on a regularbasis and adjust them as needed.Concentrations of Business and Credit RiskFinancial instruments that potentially subject us to credit risk consist of cash, cash equivalents, investments, and accounts receivable. Our cash, cashequivalents, and investments may consist of deposits held with banks, money market funds, and other highly liquid investments that may at times exceed federallyinsured limits. Cash equivalents and investments are financial instruments that potentially subject us to concentrations of risk. Under our investment policy, weinvest primarily in securities issued by the U.S. government. The goals of our investment policy, in order of priority, are as follows: preserve capital, meet liquidityneeds, and optimize returns.We generally do not require collateral to support credit sales. To reduce credit risk, we perform credit evaluations of our customers. No single customerrepresented more than 10% of total revenue for 2016 , 2015 , or 2014 , and no single customer represented more than 10% of total accounts receivable atDecember 31, 2016 , 2015 , or 2014 .67Our products include components that are currently procured from a single source or a limited number of sources. We believe that other vendors would beable to provide similar components; however, the qualification of such vendors may require start-up time. In order to mitigate any adverse impacts from adisruption of supply, we attempt to maintain an adequate supply of critical limited-source components.InventoriesInventories are stated at the lower of cost (on a first-in, first-out basis) or market. Inventory costs include direct materials, direct labor, and normalmanufacturing overhead. Finished goods that are used for research and development are expensed as consumed or depreciated over their period of use. Provisionsfor slow-moving, excess, and obsolete inventories are recorded when required to reduce inventory values to their estimated net realizable values based on productlife cycle, development plans, product expiration, and quality issues.Property and Equipment and Long-Lived AssetsProperty and equipment, including leasehold improvements, are stated at cost less accumulated depreciation. Accumulated depreciation is calculated usingthe straight-line method over the estimated useful lives of the assets, which range from three to seven years. Leasehold improvements are amortized using thestraight-line method over the estimated useful lives of the assets or the remaining term of the lease, whichever is shorter. Depreciation expense for the years endedDecember 31, 2016, 2015 and 2014 was $5.1 million , $3.6 million and $3.0 million , respectively.We evaluate our long-lived assets for indicators of possible impairment when events or changes in circumstances indicate the carrying amount of an assetmay not be recoverable. If any indicator of impairment exists, we assess the recoverability of the affected long-lived assets by determining whether the carryingvalue of the asset can be recovered through undiscounted future operating cash flows. If impairment is indicated, we estimate the asset’s fair value using futurediscounted cash flows associated with the use of the asset, and adjust the carrying value of the asset accordingly. We did not recognize any impairment of long-lived assets for any of the periods presented herein.Investment, at CostIn February 2013, Illumina, Inc. acquired Verinata Health, Inc. (Verinata), a privately-held company, for $350 million in cash and up to an additional $100million in milestone payments through December 2015. In March 2013, we received cash proceeds of $3.1 million in exchange for our ownership interest inVerinata resulting in a gain of $1.8 million . During 2014, we received cash proceeds of $0.3 million from the escrow account related to the acquisition. Werecorded these amounts as Gain from sale of investment in Verinata in the accompanying consolidated statements of operations for the years ended December 31,2013 and 2014. The final milestones related to the sale of Verinata to Illumina were met in December 2015 and, accordingly, we recorded our share of thesemilestone payment obligations in the amount of $2.3 million in Other Assets and Gain from sale of investment in Verinata in the accompanying consolidatedstatement of operations for the year ended December 31, 2015. In January 2016, we received payment of $2.3 million and it was recorded in net cash provided byinvesting activities in the consolidated statement of cash flows.Intangible AssetsOur intangible assets include developed technology, patents and licenses. We evaluate our intangible assets for indicators of possible impairment whenevents or changes in circumstances indicate the carrying amount of an asset may not be recoverable. If any indicator of impairment exists, we assess therecoverability of the affected intangible assets by determining whether the carrying value of the asset can be recovered through undiscounted future operating cashflows. If impairment is indicated, we estimate the asset’s fair value using future discounted cash flows associated with the use of the asset, and adjust the carryingvalue of the asset accordingly. We did not recognize any impairment on intangible assets for any of the periods presented herein.68Product WarrantiesWe generally provide a one -year warranty on our instruments. We accrue for estimated warranty obligations at the time of product shipment. Weperiodically review our warranty liability and record adjustments based on the terms of warranties provided to customers, and historical and anticipated warrantyclaim experience. This expense is recorded as a component of cost of product revenue in the consolidated statements of operations.Revenue RecognitionWe generate revenue from sales of our products, services, license agreements, and government grants. Our products consist of instruments and consumables,including IFCs, assays, and reagents. Our service revenue consists of post-warranty service contracts, preventive maintenance plans, instrument parts, installation,and training.We recognize revenue when persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the price to the customer isfixed or determinable, and collectability is reasonably assured. We assess collectability based on factors such as the customer’s creditworthiness and past collectionhistory, if applicable. If collection is not reasonably assured, revenue recognition is deferred until receipt of payment. We also assess whether a price is fixed ordeterminable by, among other things, reviewing contractual terms and conditions related to payment. Delivery occurs when there is a transfer of title and risk ofloss passes to the customer. Revenue excludes taxes collected from our customers.Product and Service RevenueCertain of our sales contracts involve the delivery of multiple products and services within contractually binding arrangements. Multiple-deliverable salestransactions typically consist of the sale and delivery of one or more instruments and consumables together with one or more of our installation, training and/orcustomer support services. Significant judgment is sometimes required to determine the appropriate accounting for such arrangements, including whether thedeliverables specified in a multiple element arrangement should be treated as separate units of accounting for revenue recognition purposes and, if so, how therelated sales price should be allocated among the elements, when to recognize revenue for each element, and the period over which revenue should be recognized.For sales contracts that include multiple deliverables, we allocate the contract consideration at the inception of the contract to each unit of accounting basedupon its relative selling price. We may use our best estimate of selling price forindividual deliverables when vendor specific objective evidence or third-party evidence is unavailable. A delivered item is considered to be a separate unit ofaccounting when it has value to the customer on a stand-alone basis.Our products, other than service contracts, are typically delivered within a short time frame, generally within one to three months of the contract date.Service contracts are entered into for terms of one to three years, following the expiration of the warranty period.Our products are generally sold without the right of return. Amounts received before revenue recognition criteria are met are classified in the consolidatedbalance sheets as deferred revenue or customer deposits, depending on the terms of the arrangement.License RevenueLicense and royalty revenue from license agreements is recognized when received, which is generally in the quarter following the quarter in which thecorresponding sales occur.Grant RevenueWe have received grants from various governmental entities for research and related activities. Grants provide us with payments for certain types of researchand development activities performed over a contractually defined period. Grant revenue is recognized in the period during which the related costs are incurred,provided that the conditions under which the grants were provided have been met and we have only perfunctory obligations outstanding. Amounts received inadvance of revenue recognition are classified as deferred revenue in the consolidated balance sheets. Costs associated with grants are included in research anddevelopment expenses in the consolidated statements of operations.69Shipping and Handling CostsShipping and handling costs incurred for product shipments are included within cost of product revenue in the consolidated statements of operations.Research and DevelopmentWe recognize research and development expenses in the period incurred. Research and development expenses consist of personnel costs, independentcontractor costs, prototype and materials expenses, allocated facilities and information technology expenses, and related overhead expenses.Advertising CostsWe expense advertising costs as incurred. We incurred advertising costs of $2.3 million , $2.9 million and $4.2 million during 2016 , 2015 , and 2014 ,respectively.Income TaxesWe use the asset and liability method to account for income taxes. Deferred tax assets and liabilities are recognized for the future tax consequencesattributable to temporary differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred taxassets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to berecovered or settled. Valuation allowances are provided when the expected realization of deferred tax assets does not meet a “more likely than not” criterion. Wemake estimates and judgments about our future taxable income that are based on assumptions that are consistent with our plans and estimates. Should the actualamounts differ from our estimates, the amount of our valuation allowance could be materially impacted. Changes in these estimates may result in significantincreases or decreases to our tax provision in a period in which such estimates are changed, which in turn would affect net income or loss.We recognize the financial statement effects of a tax position when it is more likely than not, based on the technical merits, that the position will be sustainedupon examination. Any interest and penalties related to uncertain tax positions are reflected in the income tax provision.Stock-Based CompensationWe account for stock options and restricted stock units granted to employees and directors based on the fair value of the awards. We recognize stock-basedcompensation expense on a straight-line basis over the requisite service periods. For performance-based stock awards, stock-based compensation expense isrecognized over the requisite service period when the achievement of each individual performance goal becomes probable. Comprehensive LossComprehensive loss is comprised of net loss and other comprehensive income (loss). Other comprehensive income (loss) consists of unrealized gains andlosses on our investments and foreign currency translation adjustments. Total comprehensive loss for all periods presented has been disclosed in the consolidatedstatements of comprehensive loss.70The components of accumulated other comprehensive loss, net of tax, for the years ended December 31, 2016 , 2015 , and 2014 are as follows (inthousands): Foreign Currency TranslationAdjustment Unrealized Gain (Loss) onInvestments Accumulated OtherComprehensive Income (Loss)Beginning balance at December 31, 2014 $(745) $(49) $(794)Change during the year (327) (23) (350)Ending balance at December 31, 2015 (1,072) (72) (1,144)Change during the year 314 70 384Ending balance at December 31, 2016 $(758) $(2) $(760)De minimus amounts of unrealized gains and losses have been reclassified into the consolidated statement of operations for the years ended December 31,2015 and 2016.Business CombinationsAssets acquired and liabilities assumed as part of a business combination are generally recorded at their fair values at the date of acquisition. The excess ofpurchase price over the fair value of assets acquired and liabilities assumed is recorded as goodwill. Determining fair value of identifiable assets, particularlyintangibles, and liabilities acquired requires management to make estimates, which are based on all available information and, in some cases, assumptions withrespect to the timing and amount of future revenues and expenses associated with an asset. Accounting for business acquisitions requires management to makejudgments as to whether a purchase transaction is a multiple element contract, meaning that it includes other transaction components such as a settlement of apreexisting relationship. This judgment and determination affects the amount of consideration paid that is allocable to assets and liabilities acquired in the businesspurchase transaction. See Note 4.Long-lived Assets, including GoodwillGoodwill and intangible assets with indefinite lives are not subject to amortization, but are tested for impairment on an annual basis during the fourth quarteror whenever events or changes in circumstances indicate the carrying amount of these assets may not be recoverable. We first conduct an assessment of qualitativefactors to determine whether it is more likely than not that the fair value of our reporting unit is less than its carrying amount. If we determine that it is more likelythan not that the fair value of our reporting unit is less than its carrying amount, we then conduct a two-step test for impairment of goodwill. In the first step, wecompare the fair value of our reporting unit to its carrying value. If the fair value of our reporting unit exceeds its carrying value, goodwill is not consideredimpaired and no further analysis is required. If the carrying values of the reporting unit exceed its fair value, then the second step of the impairment test must beperformed in order to determine the implied fair value of the goodwill. If the carrying value of the goodwill exceeds its implied fair value, then an impairment lossequal to the difference would be recorded.We evaluate our finite lived intangible assets for indicators of possible impairment when events or changes in circumstances indicate that the carryingamount of an asset may not be recoverable. If any indicator of impairment exists, we assess the recoverability of the affected intangible asset by determiningwhether the carrying value of the asset can be recovered through undiscounted future operating cash flows. If impairment is indicated, we estimate the asset’s fairvalue using future discounted cash flows associated with the use of the asset, and adjust the carrying value of the asset accordingly.Net Loss per ShareOur basic and diluted net loss per share is calculated by dividing net loss by the weighted-average number of shares of common stock outstanding for theperiod. Restricted stock units and options to purchase our common stock are considered to be potentially dilutive common shares but have been excluded from thecalculation of diluted net loss per share as their effect is anti-dilutive for all periods presented.71The following potentially dilutive common shares were excluded from the computations of diluted net loss per share for the periods presented becauseincluding them would have been anti-dilutive (in thousands): At December 31, 2016 2015 2014Stock options, restricted stock units and performance awards 4,622 3,905 3,736Convertible notes 3,598 3,598 3,598Total 8,220 7,503 7,334Recent Accounting PronouncementsIn May 2014, the Financial Accounting Standards Board (FASB) issued Accounting Standard Update (ASU) 2014-09 regarding ASC (Topic 606) Revenuefrom Contracts with Customers. ASU 2014-09 provides principles for recognizing revenue to depict the transfer of promised goods or services to customers in anamount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. In May 2016, the FASB issued ASU 2016-12, which provides narrow scope improvements and practical expedients related to ASU 2014-09. The improvements address completed contracts and contractmodifications at transition, non-cash consideration, the presentation of sales taxes and other taxes collected from customers, and assessment of collectability whendetermining whether a transaction represents a valid contract. On July 7, 2015, the FASB amended ASU 2014-09 to defer the effective date by one year with earlyadoption permitted as of the original effective date. ASU 2014-09 and ASU 2016-12 will be effective for our fiscal year beginning January 1, 2018, with earlyadoption permitted. While we have not completed our assessment of the new revenue recognition standard, we currently expect that this new standard will not havea material impact on our consolidated financial statements. We expect to adopt ASU 2014-09 in the first quarter of 2018.In April 2015, the FASB issued ASU 2015-03, Interest - Imputation of Interest (Subtopic 835-30): Simplifying the Presentation of Debt Issuance Costs. Thisguidance is intended to simplify the presentation of debt issuance costs. These amendments require that debt issuance costs related to a recognized debt liability bepresented in the balance sheet as a direct deduction from the carrying amount of that debt liability, consistent with debt discounts. ASU 2015-03 was effective forour interim and annual financial statements beginning in the first quarter of 2016. We applied this guidance in our financial statements commencing the firstquarter of 2016. Unamortized debt issuance costs of $1.0 million as of December 31, 2015 were reclassified from other non-current assets to a deduction fromConvertible Notes, net in the consolidated balance sheets.In July 2015, the FASB issued ASU 2015-11 Inventory (Topic 330): Simplifying the Measurement of Inventory, which changes the measurement principlefor inventory from the lower of cost or market to the lower of cost or net realizable value. ASU 2015-11 defines net realizable value as estimated selling prices inthe ordinary course of business, less reasonably predictable costs of completion, disposal, and transportation. It will be effective for our interim and annualfinancial statements beginning in the first quarter of 2017 and early adoption is permitted. We will adopt this standard in the first quarter of 2017. The adoption ofthis standard is not expected to have a material impact on our consolidated financial statements.In November 2015, the FASB issued ASU 2015-17 Income Taxes (Topic 740), Balance Sheet Classification of Deferred Taxes, effective for annual periodsbeginning after December 15, 2016. The amendments in this update require that in a classified statement of financial position, an entity shall classify deferred taxliabilities and assets as non-current, and an entity shall not offset deferred tax liabilities and assets attributable to different tax-paying components of the entity or todifferent tax jurisdictions. We elected to early adopt this guidance in the fourth quarter of 2016 on a prospective basis. Prior periods were not retrospectivelyadjusted.In February 2016, the FASB issued ASU 2016-02 Leases (Topic 842). This ASU requires lessees to recognize a right-of-use asset and a lease liability on thebalance sheet for all leases with the exception of short-term leases. For lessees, leases will continue to be classified as either operating or finance leases in theincome statement. Lessor accounting is similar to the current model but updated to align with certain changes to the lessee model. Lessors will continue to classifyleases as operating, direct financing or sales-type leases. ASU 2016-02 will be effective for our fiscal year beginning January 1, 2019 and early adoption ispermitted. We are currently evaluating the accounting, transition, and disclosure requirements of the standard. We have not yet determined whether we will electearly adoption of the standard and cannot currently estimate the financial statement impact of adoption.72In March 2016, the FASB issued ASU 2016-09 Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based PaymentAccounting. This ASU simplifies several aspects of the accounting for share-based payments, including changing the threshold to qualify for equity classificationup to the employees’ maximum statutory tax rates, allowing an entity-wide accounting policy election to either estimate the number of awards that are expected tovest or account for forfeitures as they occur, and clarifying the classification on the statement of cash flows employee taxes paid when an employer withholdsshares for tax-withholding purposes. ASU 2016-09 will be effective for our fiscal year beginning January 1, 2017. We will adopt this standard in the first quarter of2017 by recording the cumulative impact of applying this guidance to retained earnings, which is not expected to be material. We will also elect to account forforfeitures as they occur, as permitted by ASU 2016-09.In November 2016, the FASB issued ASU 2016-18 Statement of Cash Flows (Topic 230): Restricted Cash, a consensus of the FASB’s Emerging Issues TaskForce, amending the presentation of restricted cash within the statement of cash flows. The new guidance requires that restricted cash be included within cash andcash equivalents on the statement of cash flows. ASU 2016-18 will be effective for our fiscal year beginning after January 1, 2018, with early adoption permitted.The adoption of this ASU is not expected to have a material impact on our consolidated financial statements.In January 2017, the FASB issued ASU 2017-04, Intangibles - Goodwill and Other (Topic 350): Simplifying The Test for Goodwill Impairment. The newguidance intends to simplify the subsequent measurement of goodwill. The ASU eliminates the requirement for an entity to calculate the implied fair value ofgoodwill to measure a goodwill impairment charge. Instead, an entity will perform its annual, or interim, goodwill impairment testing by comparing the fair valueof a reporting unit with its carrying amount and recording an impairment charge for the amount by which the carrying amount exceeds the fair value. The ASU willbe effective for annual and interim goodwill impairment testing performed for our fiscal year beginning January 1, 2020, with early adoption permitted. We arecurrently evaluating the adoption of this ASU and cannot estimate the financial statement impact of adoption.There have been no other changes in accounting standards issued by the FASB during the year ended December 31, 2016 that are expected to have a materialimpact on our financial position, results of operations or cash flows.3. Intangible Assets, netDeveloped TechnologyIn connection with the acquisition of DVS in February 2014, we acquired developed technology with a gross fair value of $112.0 million . These acquiredintangible assets are being amortized to cost of product revenue over their useful life of ten years. Related amortization expense for the years ended December 31,2016 , 2015 and 2014 was $11.2 million , $11.2 million and $9.8 million , respectively. For further discussion related to intangible assets acquired in 2014 from theDVS acquisition, see Note 4.PatentsOn June 28, 2013, we acquired certain patents, patent applications, and licenses from Helicos Biosciences Corporation (Helicos) relating to Helicos’ next-generation sequencing technology. The rights acquired by us are subject to certain licenses and sublicenses granted by Helicos prior to or contemporaneously withour acquisition. The assets were acquired for $1.0 million and we incurred transaction costs of approximately $0.3 million . The patents, patent applications, andlicenses have an alternative future use and, as a result, the acquired assets and transaction costs are capitalized as intangible assets and are included in other non-current assets. The acquired assets from Helicos are being amortized to research and development expense over their useful life of ten years. Related amortizationexpense was $127,000 for each of the years ended 2016 , 2015 and 2014 .On November 4, 2015, we entered into a patent purchase agreement with PerkinElmer Health Sciences, Inc. (PerkinElmer) pursuant to which we purchasedthe Patents for a purchase price of $6.5 million and a patent assignment agreement pursuant to which PerkinElmer transferred and assigned to us all rights, title,privileges, and interest in and to the Patents and the Original License Agreement, between Fluidigm Canada Inc. and PerkinElmer. Accordingly, we have no furtherfinancial obligations to PerkinElmer under the Original License Agreement. The Patents are being amortized to cost of product73revenue through their useful life. Related amortization expense for the years ended December 31, 2016 and 2015 was $0.9 million and $0.1 million , respectively.LicensesOn June 30, 2011, we settled certain litigation and entered into a series of patent license agreements with Life Technologies Corporation (now part of ThermoFisher Scientific) and its subsidiary, Applied Biosystems, LLC (collectively, Life). The agreements resulted in a net $3.0 million payment by us to Life, whichwas recognized as a litigation settlement expense. The agreements also provide for various royalty payments on future sales of certain products by each of theparties. Such royalty payments or receipts have not been and are not expected to be material to us. Under the terms of the agreements, in July 2011, we paid Life$2.0 million in connection with the exercise of our option to limit or preclude certain patent litigation between us and Life for a period of two to four years. As aresult, subject to certain exceptions, Life may not initiate litigation under its patents existing as of June 30, 2011 against us, with respect to its current products andequivalent future products, for a period of four years. The additional payment was included in other assets and is being amortized to selling, general andadministrative expense over four years on a straight-line basis beginning in July 2011. The additional payment is being amortized to selling, general andadministrative expense because it precludes Life from initiating litigation for a period of four years under its relevant patents for any alleged prior and futureinfringement by us, and because such preclusion relates to our equivalent future products. We recognized $0.3 million and $0.5 million of amortization expenseduring 2015 and 2014 , respectively. The patent licenses were fully amortized in 2015.In May 2011, we entered into an agreement with Caliper Life Sciences, Inc., which subsequently became a PerkinElmer company (Caliper), to licenseCaliper’s existing patent portfolio in certain fields, including non-invasive prenatal diagnostics, and obtained an option to extend this license to cover additionalfields. Additional payments are due if we exercise our option to extend the license. Under this agreement, we made an up-front payment of $0.6 million and ourobligation to pay royalties to Caliper commenced in January 2012. In August 2011, we entered into an amendment to the agreement with Caliper and made anadditional up-front payment of $0.5 million . Pursuant to the amendment, the rates for royalties payable to Caliper were substantially reduced and the period forwhich we are obligated to make royalty payments was shortened, with the last payment due in mid-2018 for our existing products at the time of amendment andtheir future equivalents. If any of our future products are determined to infringe Caliper’s patents, the same reduced royalty rates will apply until the respectivepatents expire. The aggregate $1.1 million of payments to Caliper are being amortized to cost of product revenue on a straight-line basis through July 2018, whenour royalty payment obligations are expected to terminate based upon our current products. We recognized $0.3 million in cost of product revenue during each yearof 2016 , 2015 , and 2014 . Our future royalty payments are not expected to be material.Intangible assets include developed technology as a result of the DVS acquisition and other intangible assets included in the Other non-current assets.Intangible assets, net were as follows (in thousands): December 31, 2016 Gross Amount AccumulatedAmortization Net Weighted-AverageAmortization PeriodDeveloped technology$112,000 $(32,200) $79,800 10.0 yearsPatents and licenses11,224 (4,533) 6,691 7.9 yearsTotal intangible assets, net$123,224 $(36,733) $86,491 December 31, 2015 Gross Amount AccumulatedAmortization Net Weighted-AverageAmortization PeriodDeveloped technology$112,000 $(21,000) $91,000 10.0 yearsPatents and licenses11,224 (3,330) 7,894 7.9 yearsTotal intangible assets, net$123,224 $(24,330) $98,894 74Based on the carrying value of intangible assets, net as of December 31, 2016 , the annual amortization expense for intangible assets, net is expected to be asfollows (in thousands): Fiscal Year Amortization Expense2017 $12,3902018 12,3252019 12,2342020 12,2342021 12,079Thereafter 25,229Total $86,4914. AcquisitionOn February 13, 2014 (Acquisition Date), we acquired DVS primarily to broaden our addressable single-cell biology market opportunity and complementour existing product offerings. DVS develops, manufactures, markets, and sells high-parameter single-cell protein analysis systems and related reagents and dataanalysis tools. DVS’s principal market is the life sciences research market consisting of drug development companies, government research centers, anduniversities worldwide.The contractual price for the acquisition was $207.5 million , subject to certain adjustments as specified in the merger agreement. The measurement periodfor the acquisition ended February 12, 2015. The aggregate purchase price was $199.9 million , as detailed in the table below (in thousands): Estimated Fair ValueCash $126,048Issued 1,759,007 shares of Fluidigm common stock (2) 76,805Acquisition consideration paid at Acquisition Date 202,853Accelerated stock compensation (1) (6,690)Estimated fair value of vested Fluidigm equivalent stock options (2) 4,039Working capital adjustment (269) Aggregate purchase price $199,933(1)As a part of the acquisition, we accelerated vesting of certain DVS stock options and shares of restricted stock, and incurred a $6.7 million expense, basedupon the per share consideration paid to holders of shares of DVS common stock as of February 13, 2014. This expense is accounted for as a separatetransaction and reflected in the acquisition-related expenses line of the consolidated statements of operations.(2)In conjunction with the acquisition, we assumed all outstanding DVS stock options and unvested shares of restricted stock and converted, as of theAcquisition Date, the unvested stock options outstanding under the DVS stock option plan into unvested stock options to purchase approximately 143,000shares of Fluidigm common stock and the unvested DVS restricted stock into approximately 186,000 shares of restricted Fluidigm common stock,retaining the original vesting schedules. These restricted shares have been included in the "Issuance of common stock upon purchase of DVS" line item inthe Consolidated Statement of Stockholders' Equity. The fair value of all converted share-based awards was $14.6 million , of which $4.0 million wasattributed to the pre-combination service period and was included in the calculation of the purchase price. The remaining fair value will be recognizedover the awards’ remaining vesting periods subsequent to the acquisition. The fair value of the Fluidigm equivalent share-based awards as of theAcquisition Date was estimated using the Black-Scholes valuation model.Approximately 885,000 shares of Fluidigm common stock, with a fair value of $ 38.6 million , representing 50.3030% of the shares otherwise payable to theformer stockholders of DVS, were deposited into escrow (Escrowed Shares). These Escrowed Shares comprised a portion of the merger consideration and wereheld in escrow to secure indemnification obligations under the merger agreement. Under the terms of the merger agreement, fifty percent ( 50.0% ) of the aggregateshares subject to the indemnification escrow were eligible for release on March 13, 2015 (Initial Release Date), and the balance of the75shares were subject to release on August 13, 2015, provided that in each case shares would have continued to be held in escrow in amounts that we reasonablydetermined in good faith to be necessary to satisfy any claims for which we had delivered a notice of claim which had not been fully resolved between us and therepresentative of the former stockholders of DVS (Stockholder Representative). Prior to the Initial Release Date, we submitted escrow claim notices under theterms of the merger agreement. On April 9, 2015, the Stockholder Representative provided notices objecting to our claims. In July 2015, we entered into asettlement agreement with the Stockholder Representative regarding the claims (Settlement Agreement). Pursuant to the terms of the Settlement Agreement, theparties agreed to release approximately 80% of the Escrowed Shares to the former stockholders of DVS, and the remaining approximately 20% of the EscrowedShares, or 170,107 shares, to us, which were canceled and returned to the status of authorized and unissued shares. Additionally, the parties agreed to, among otherthings, release various claims and waive certain rights with respect to the merger agreement. On the settlement date, the 170,107 shares had a value ofapproximately $4.0 million , which was recorded as gain on escrow settlement during the quarter ended September 30, 2015.The results of DVS's operations have been included in the consolidated financial statements since the date of acquisition, including $20.7 million in revenuefor the year ended December 31, 2014.Net Assets AcquiredThe transaction has been accounted for using the acquisition method of accounting which requires that assets acquired and liabilities assumed be recognizedat their fair values as of the Acquisition Date. The following table summarizes the assets acquired and liabilities assumed as of the Acquisition Date (in thousands): Allocation of Purchase PriceCash and cash equivalents $8,405Accounts receivable, net 7,698Inventories 3,489Prepaid expenses and other current assets 1,482Property and equipment, net 1,202Developed technology 112,000Goodwill 104,108Other non-current assets 88 Total assets acquired 238,472Accounts payable (1,114)Accrued compensation and related benefits (761)Other accrued liabilities (1,204)Deferred revenue, current (1,844)Tax payable (45)Deferred tax liability (31,942)Deferred revenue, non-current (1,629) Net assets acquired $199,933The $104.2 million of goodwill recognized as part of the transaction is attributable primarily to expected synergies and other benefits from the acquisition,including expansion of our addressable market from the single-cell genomics market to the larger single-cell biology market and the ability to leverage our largerglobal commercial sales organization and infrastructure to expand awareness of DVS's products and technology. Goodwill is not deductible for income taxpurposes. The only change to goodwill between the Acquisition Date and December 31, 2014 was an adjustment of $0.1 million to the deferred taxes liabilityresulting from the final tax analysis during the measurement period. There were no changes in goodwill between December 31, 2015 and December 31, 2016.76Goodwill is tested for impairment annually during the fourth quarter unless a triggering event requires an expedited analysis. During the fourth quarters of2016 and 2015, we completed our annual impairment assessments and we concluded that goodwill was not impaired in any of these years.Acquisition CostsAcquisition-related expenses were $10.7 million in 2014 and primarily included accelerated vesting of certain DVS restricted stock and options, andconsulting, legal, and investment banking fees. These costs are included within the acquisition-related expenses line of the consolidated statements of operations.No such costs were incurred in 2016 or 2015.Unaudited Pro Forma ResultsThe unaudited financial information in the table below summarizes our results of operations combined with DVS's as though the companies were combinedas of the beginning of each of the years presented. The unaudited pro forma information does not necessarily reflect the actual results of operations had theacquisition been consummated at the beginning of the fiscal reporting periods indicated nor is it indicative of future operating results.(in thousands) Year Ended December 31 2014 2013Pro forma total revenue $120,245 $98,459Pro forma net loss $(55,249) $(37,906)The unaudited pro forma financial information for the year ended December 31, 2014 includes adjustments related to stock-based compensation,amortization of developed technology, interest expense, and deferred tax liability of $1.4 million , $1.4 million , $1.0 million , and $371,000 , respectively, andincludes non-recurring adjustments representing the total acquisition-related expenses discussed above. The unaudited pro forma financial information for the yearended December 31, 2013 includes adjustments related to stock-based compensation, amortization of developed technology, interest expense, and deferred taxliability of $9.2 million , $11.2 million , $5.8 million , and $3.0 million , respectively.775. Fair Value of Financial InstrumentsThe following tables summarize our cash and available-for-sale securities that were measured at fair value by significant category within the fair valuehierarchy (in thousands): December 31, 2016 CarryingAmount Gross UnrealizedGain Gross UnrealizedLoss Fair Value Cash and CashEquivalents Short-TermMarketableSecurities Long-TermMarketableSecuritiesAssets: Cash$13,984 $— $— $13,984 $13,984 $— $—Available-for-sale: Level I: Money market funds21,061 — — 21,061 21,061 — — Level II: U.S. government and agencysecurities24,388 1 (4) 24,385 — 24,385 —Total$59,433 $1 $(4) $59,430 $35,045 $24,385 $— December 31, 2015 CarryingAmount Gross UnrealizedGain Gross UnrealizedLoss Fair Value Cash and CashEquivalents Short-TermMarketableSecurities Long-TermMarketableSecuritiesAssets: Cash$17,889 $— $— $17,889 $17,889 $— $—Available-for-sale: Level I: Money market funds11,228 — — 11,228 11,228 — — Level II: U.S. government and agencysecurities72,420 — (72) 72,348 — 65,855 6,493Total$101,537 $— $(72) $101,465 $29,117 $65,855 $6,493The contractual maturity periods of $24.4 million of debt securities are within one year from December 31, 2016 .There were no transfers between Level I and Level II measurements during the year ended December 31, 2016, and there were no changes in the valuationtechniques used.Based on an evaluation of securities that were in a loss position, we did not recognize any other-than-temporary impairment charges for the years endedDecember 31, 2016 , 2015 , and 2014 . None of our investments have been in a continuous loss position for more than 12 months. We concluded that the declinesin market value of our available-for-sale securities investment portfolio were temporary in nature and did not consider any of our investments to be other-than-temporarily impaired.The estimated fair value of the 2.75% Convertible Notes is based on a market approach (See Note 7 for Convertible Notes). The estimated fair value wasapproximately $139.7 million and $118.8 million (par value $201.3 million ) as of December 31, 2016 and December 31, 2015 , respectively, and represents aLevel II valuation. When determining the estimated fair value of our long-term debt, we used a commonly accepted valuation methodology and market-based riskmeasurements that are indirectly observable, such as credit risk.786. Balance Sheet DataCash and Cash EquivalentsCash and cash equivalents consisted of the following as of December 31, 2016 and 2015 (in thousands): December 31,Cash and cash equivalents: 2016 2015Cash $13,984 $17,889Money market funds 21,061 11,228Total $35,045 $29,117InventoriesInventories consisted of the following as of December 31, 2016 and 2015 (in thousands): December 31,Inventories: 2016 2015Raw materials $8,919 $6,829Work-in-process 1,742 2,442Finished goods 9,453 8,653Total inventories, net $20,114 $17,924Property and EquipmentProperty and equipment consisted of the following as of December 31, 2016 and 2015 (in thousands): December 31,Property and equipment: 2016 2015Computer equipment and software $5,497 $5,048Laboratory and manufacturing equipment 23,670 21,783Leasehold improvements 8,747 5,875Office furniture and fixtures 2,084 1,584Property and equipment, gross 39,998 34,290Less accumulated depreciation and amortization (24,084) (19,618)Construction-in-progress 611 586Property and equipment, net $16,525 $15,258 Product WarrantiesActivity for our warranty accrual for the years ended December 31, 2016 and 2015 , which are included in other accrued liabilities, is summarized below (inthousands): Year Ended December 31, 2016 2015Beginning balance $1,076 $1,178Accrual for current period warranties 885 672Warranty costs incurred (938) (774)Ending balance $1,023 $1,076797. Convertible NotesOn February 4, 2014, we closed an underwritten public offering of $201.3 million aggregate principal amount of our 2.75% Senior Convertible Notes due2034 (Notes) pursuant to an underwriting agreement, dated January 29, 2014. The Notes accrue interest at a rate of 2.75% per year, payable semi-annually inarrears on February 1 and August 1 of each year, commencing August 1, 2014. The Notes will mature on February 1, 2034, unless earlier converted, redeemed, orrepurchased in accordance with the terms of the Notes. The initial conversion rate of the Notes is 17.8750 shares of our common stock, par value $0.001 per share,per $1,000 principal amount of Notes (which is equivalent to an initial conversion price of approximately $55.94 per share). The conversion rate will be subject toadjustment upon the occurrence of certain specified events. Holders may surrender their Notes for conversion at any time prior to the stated maturity date. On orafter February 6, 2018 and prior to February 6, 2021, we may redeem any or all of the Notes in cash if the closing price of our common stock exceeds 130% of theconversion price for a specified number of days, and on or after February 6, 2021, we may redeem any or all of the Notes in cash without any such condition. Theredemption price of the Notes will equal 100% of the principal amount of the Notes plus accrued and unpaid interest. Holders may require us to repurchase all or aportion of their Notes on each of February 6, 2021, February 6, 2024, and February 6, 2029 at a repurchase price in cash equal to 100% of the principal amount ofthe Notes plus accrued and unpaid interest. If we undergo a fundamental change, as defined in the terms of the Notes, holders may require us to repurchase theNotes in whole or in part for cash at a repurchase price equal to 100% of the principal amount of the Notes plus accrued and unpaid interest.In February 2014, we received $195.2 million , net of underwriting discounts, from the issuance of the Notes and incurred approximately $1.1 million inoffering-related expenses. The underwriting discount of $6.0 million and the debt issuance costs of $1.1 million were recorded as offsets to the proceeds.In February 2014, we used $113.2 million of the net proceeds to fund the cash portion of the consideration payable by us in connection with our acquisitionof DVS (now Fluidigm Sciences Inc.) (See Note 4). Interest expense related to the Notes was approximately $5.8 million , $5.8 million and $5.3 million during2016 , 2015 and 2014, respectively. Accrued interest related to the Notes as of December 31, 2016 and 2015 were both $2.3 million , respectively, which wereincluded in Other current liabilities. Approximately $5.5 million of interest under the Notes were paid for each year ended December 31, 2016 and 2015 ,respectively.The carrying values of the components of the Notes are as follows (in thousands): December 31, 2016 2015Principal amount of Notes $201,250 $201,250Unamortized debt discount (5,330) (5,566)Unamortized debt issuance cost (969) (1,011) Net carrying value of convertible notes $194,951 $194,673808. Commitments and ContingenciesOperating LeasesWe have entered into various long-term non-cancelable operating lease agreements for equipment and facilities expiring at various times through 2026. Wealso leased office space under non-cancelable leases in the United States, Canada, Singapore, Japan, China, France and United Kingdom, with various expirationdates through March 2026. Certain facility leases also contain rent escalation clauses. Our lease payments are expensed on a straight-line basis over the life of theleases. Rental expense under operating leases, net of amortization of lease incentive, totaled $6.3 million , $5.2 million , and $4.0 million for 2016, 2015, and 2014,respectively.Future minimum lease payments under non-cancelable operating leases as of December 31, 2016 are as follows (in thousands):Fiscal Year Minimum Lease Payments2017 $4,2852018 4,4452019 4,7692020 2,5502021 1,379Thereafter 2,605Total $20,033Other CommitmentsIn the normal course of business, we enter into various contractual and legally binding purchase commitments. As of December 31, 2016 , thesecommitments through the next two years were approximately $4.2 million .IndemnificationsFrom time to time, we have entered into indemnification provisions under certain of our agreements in the ordinary course of business, typically withbusiness partners, customers, and suppliers. Pursuant to these agreements, we may indemnify, hold harmless, and agree to reimburse the indemnified parties on acase-by-case basis for losses suffered or incurred by the indemnified parties in connection with any patent or other intellectual property infringement claim by anythird party with respect to our products. The term of these indemnification provisions is generally perpetual from the time of the execution of the agreement. Themaximum potential amount of future payments we could be required to make under these indemnification provisions is typically not limited to a specific amount.In addition, we have entered into indemnification agreements with our officers, directors, and certain other employees. With certain exceptions, these agreementsprovide for indemnification for related expenses including, among others, attorneys' fees, judgments, fines and settlement amounts incurred by any of theseindividuals in any action or proceeding.Since October 2015, we have been incurring legal expenses in the defense of claims by Thermo Fisher Scientific, Inc., (Thermo) against one of ouremployees. On December 21, 2015, Thermo filed a complaint in the Circuit Court for the County of Kalamazoo of Michigan against one of its former employeeswho had recently been hired by us alleging, among other claims, misappropriation of proprietary information and breach of contractual and fiduciary obligations toThermo while still an employee of Thermo. On November 23, 2016, Thermo amended its complaint to add us as a party to the litigation, making variouscommercial and employment-related claims and seeking damages and injunctive relief.81Contingencies From time to time, we may be subject to various legal proceedings and claims arising in the ordinary course of business. These include disputes and lawsuitsrelated to intellectual property, mergers and acquisitions, licensing, contract law, tax, regulatory, distribution arrangements, employee relations and other matters.Periodically, we review the status of each matter and assess its potential financial exposure. If the potential loss from any claim or legal proceeding is consideredprobable and a range of possible losses can be estimated, we accrue a liability for the estimated loss. Legal proceedings are subject to uncertainties, and theoutcomes are difficult to predict. Because of such uncertainties, accruals are based only on the best information available at the time. As additional informationbecomes available, we continue to reassess the potential liability related to pending claims and litigation and may revise estimates.As of December 31, 2016 , we had an aggregate legal contingency accrual based on our estimate of the probable losses before considering insuranceproceeds, if any, and does not include an estimate for legal fees expected to be incurred in connection with the loss contingency. The amount of our legalcontingency accrual was not material as of December 31, 2016 .9. Stock-Based Compensation2011 Equity Incentive PlanOn January 28, 2011, our board of directors adopted the 2011 Equity Incentive Plan (the 2011 Plan) under which incentive stock options, non-statutory stockoptions, restricted stock units (RSUs), stock appreciation rights, performance units, and performance shares may be granted to our employees, directors, andconsultants.Incentive stock options and non-statutory stock options granted under the 2011 Plan have a term of no more than ten years from the date of grant and anexercise price of at least 100% of the fair market value of the underlying common stock on the date of grant. If a participant owns stock representing more than10% of the voting power of all classes of our stock on the grant date, an incentive stock option awarded to the participant will have a term of no more than fiveyears from the date of grant and an exercise price of at least 110% of the fair market value of the underlying common stock on the date of grant. Generally,outstanding options vest at a rate of either 25% on the first anniversary of the option grant date and ratably each month over the remaining period of 36 months , orratably each month over 48 months . We may grant options with different vesting terms from time to time.Our board of directors sets the terms, conditions, and restrictions related to the grant of restricted stock units, including the number of restricted stock units togrant. Our board of directors also sets vesting criteria and, depending on the extent to which the criteria are met, our board of directors will determine the numberof restricted stock units to be paid out. In general, RSUs vest on a quarterly basis over a period of four years from the date of grant, provided that no shares willvest during the first year of employment, at the end of which the shares that would have vested during the year will vest and the remaining shares will vest over theremaining 12 quarters, subject to the employees' continued employment.The exercise price of any stock appreciation right shall be determined by our board of directors but will be no less than 100% of the fair market value of theunderlying common stock on the date of grant. The stock appreciation rights expire upon the date determined by our board of directors but no later than ten yearsfrom the date of grant.Our board of directors sets the performance objectives and other vesting provisions in determining the number of shares or value of performance units andperformance shares that will be paid out. Such payout will be a function of the extent to which performance objectives or other vesting provisions have beenachieved.As of December 31, 2016 , the 2011 Plan had a total of 6,431,215 awards authorized for issuance.2009 Equity Incentive Plan and 1999 Stock Option PlanOur 2009 Equity Incentive Plan (the 2009 Plan) terminated on the date the 2011 Plan was adopted and the 1999 Stock Option Plan (the 1999 Plan) expired in2009. Options granted or shares issued under the 2009 Plan and the 1999 Plan that were outstanding on the date the 2011 Plan became effective remained subjectto the terms of their respective plans.82Activity under the 2011 Plan, the 2009 Plan, and the 1999 Plan is as follows (in thousands, except per share amounts): Stock options : Outstanding Options Shares Available for Grant Number of Shares Weighted-Average Exercise Price per ShareBalance at December 31, 2015 1,535 3,242 $20.45Additional shares authorized 1,000 — —Options granted (978) 978 $7.44Options exercised — (57) $4.04Options canceled 603 (603) $23.53Balance at December 31, 2016 2,160 3,560$16.62Restricted Stock units: Number of Nonvested andOutstanding Units Weighted-Average Grant Date Fair Valueper ShareBalance at December 31, 2015 663 $32.48RSUs granted 940 $7.06RSUs vested (328) $24.71RSUs canceled (210) $17.82Balance at December 31, 2016 1,065 $15.31We determine stock-based compensation expense using the Black-Scholes option-pricing model and the following weighted-average assumptions: Year Ended December 31, 2016 2015 2014Expected volatility 43.4% 46.3% 57.5%Expected life 6.0 years 5.9 years 5.9 yearsRisk-free interest rate 1.4% 1.8% 1.5%Dividend yield — — —Weighted-average fair value of options granted $3.19 $13.89 $9.80Expected volatility is derived by combining data from our historical volatilities and historical volatilities of unrelated public companies within the lifesciences industry. Each company’s historical volatility is weighted and combined to produce the single volatility factor used by us. The risk-free interest rate isbased on the U.S. Treasury yield curve in effect at the time of grant for zero coupon U.S. Treasury notes with maturities approximately equal to the option’sexpected life. Given our limited history as a public company, we used the “simplified” method to estimate expected lives of options granted to the variousemployee groups. The “simplified” method calculates the expected life of an option as the average of the time-to-vesting and the contractual life of the options.Forfeitures were estimated based on an analysis of actual forfeitures. We periodically evaluate the adequacy of our forfeiture rate based on actual forfeitureexperience, analysis of employee turnover, and other factors. Each of these inputs is subjective and generally requires significant judgment by us. Also required tocompute the fair value calculation of options is the fair value of the underlying common stock.We grant stock options at exercise prices not less than the fair value of our common stock at the date of grant. The fair value of options granted is based onthe closing price of our common stock on the date of grant as quoted on the NASDAQ Global Select Market.The fair value of RSUs granted to employees was estimated on the date of grant by multiplying the number of shares granted by the fair market value of ourcommon stock on the grant date.83Additional information regarding our stock options outstanding and exercisable as of December 31, 2016 is summarized in the following table: Options OutstandingExercise Price Per Share Number of Shares Weighted-AverageRemaining Contractual Life Options Exercisable (In Thousands) (In Years) (In Thousands)$0.64 - $4.76 148 3.1 147$4.76 - $9.51 932 8.8 176$9.52 - $14.27 340 7.1 203$14.27 - $19.02 1,540 5.6 1,513$19.03 - $23.78 71 7.8 64$23.79 - $28.53 105 7.8 74$28.54 - $33.29 27 6.7 21$33.30 - $38.04 6 8.0 3$38.05 - $42.80 186 7.9 95$42.81 - $47.55 205 7.0 146 3,560 6.8 2,442Options exercisable as of December 31, 2016 had a weighted-average remaining contractual life of 5.8 years, a weighted-average exercise price per share of$18.01 , and an aggregate intrinsic value of $0.6 million .Options outstanding that have vested as of December 31, 2016 or are expected to vest in the future are summarized as follows: Number of shares Weighted-Average Exercise Price per Share Weighted- Average RemainingContractual Life Aggregate Intrinsic Value (1) (In Thousands) (In Years) (In Thousands)Vested 2,442 $18.01 5.8 $589Expected to vest, net of estimated forfeitures 932 $13.24 9.1 354Total vested and expected to vest, net of forfeitures 3,374 $16.69 6.7 $943 (1)Aggregate intrinsic value was calculated as the difference between the closing stock price on the last trading day of 2016 , which was $7.28 , and theexercise price of the options, multiplied by the number of in-the-money options.The total intrinsic value of options exercised during 2016 , 2015 , and 2014 was $0.3 million , $13.7 million , and $12.8 million , respectively.The total intrinsic value of RSUs vested and released during the year ended December 31, 2016 , 2015 and 2014 were approximately $2.4 million , $1.8million and $1.4 million , respectively. The intrinsic value of vested and released RSUs is calculated by multiplying the fair market value of our common stock onthe vesting date by the number of shares vested. As of December 31, 2016 , the number of RSUs outstanding and expected to vest was 883,570 , with a totalintrinsic value of $6.4 million . The intrinsic value of the outstanding and expected to vest RSUs is calculated based on the market value of the Company's closingstock price as of December 30, 2016 of $7.28 , the last market trading day of 2016 .There were no stock-based compensation tax benefits recognized during 2016 , 2015 , or 2014 . Capitalized stock-based compensation costs wereinsignificant at December 31, 2016 , 2015 , and 2014 .84As of December 31, 2016 , there was $15.8 million of total unrecognized compensation cost related to stock-based compensation arrangements that isexpected to be recognized over an average period of 2.3 years.During 2016, we granted 184,050 and 87,620 performance-based stock options and performance-based restricted stock units (each, a “performance award”),respectively, to executive officers and employees, which were accounted for as equity awards. The number of performance awards that ultimately vest depends onthe achievement of certain performance criteria set by the Compensation Committee of the Company’s Board of Directors. The performance-based stock optionshave an exercise price per share of $7.10 . The Company recognizes stock-based compensation expense over the vesting period of the performance awards whenachievement of the performance criteria becomes probable. We did not recognize any expense related to these performance awards during 2016.10. Income TaxesOur loss before income taxes consists of the following (in thousands): Year Ended December 31, 2016 2015 2014Domestic $(65,211) $(46,757) $(41,559)International (14,966) (8,033) (16,146)Loss before income taxes $(80,177) $(54,790) $(57,705)Significant components of our benefit for income taxes are as follows (in thousands): Year Ended December 31, 2016 2015 2014Current: Federal $— $(30) $—State (14) (14) (20)Foreign 286 (1,319) (254)Total current tax benefit (expense) 272 (1,363) (274)Deferred: State — — 2,042Foreign 3,920 2,838 3,107Total deferred benefit 3,920 2,838 5,149Total benefit for income taxes $4,192 $1,475 $4,875Reconciliation of income taxes at the statutory rate to the benefit from (provision for) income taxes recorded in the statements of operations is as follows: Year Ended December 31, 2016 2015 2014Tax benefit at federal statutory rate 34.0 % 34.0 % 34.0 %State tax credit (expense), net of federal benefit 2.2 1.4 (1.5)Foreign tax expense (0.7) (1.9) (3.7)Change in valuation allowance (31.2) (28.6) (21.1)Federal research and development credit 1.3 2.6 2.7Unrecognized tax benefit (1.3) (1.8) (0.7)Return to provision reconciliation 1.5 (1.2) —Other, net (0.6) (1.9) (1.2)Effective tax rate 5.2 % 2.6 % 8.5 %85Significant components of our deferred tax assets and liabilities are as follows (in thousands): December 31, 2016 2015Deferred tax assets: Net operating loss carryforwards $123,913 $104,291Reserves and accruals 4,281 2,922Depreciation and amortization 712 548Tax credit carryforwards 12,584 11,098Stock-based compensation 7,057 7,185Total gross deferred tax assets 148,547 126,044Valuation allowance on deferred tax assets (146,285) (124,137)Total deferred tax assets, net of valuation allowance 2,262 1,907Deferred tax liabilities: Fixed asset and intangibles (22,000) (25,565)Total deferred tax liabilities (22,000) (25,565)Net deferred tax liability $(19,738) $(23,658)We evaluate a number of factors to determine the realizability of our deferred tax assets. Recognition of deferred tax assets is appropriate when realization ofthese assets is more likely than not. Assessing the realizability of deferred tax assets is dependent upon several factors including historical financial results. The netdeferred tax assets have been partially offset by a valuation allowance because we have incurred losses since our inception. The valuation allowance increased by$22.1 million and $14.0 million during 2016 and 2015, respectively. The change in valuation allowance is mainly due to a significant increase in the current yeartaxable loss and an increase in research development credits.The valuation allowances of $146.3 million and $124.1 million as of December 31, 2016 and 2015, respectively, primarily relate to temporary taxdifferences, net operating losses and research and development credits generated in the current and prior years. We believe it is more likely than not that U.S.federal, California, Japan and Singapore deferred tax assets relating to temporary differences, net operating losses and research and development credits are notrealizable. As such, full valuation allowances have been applied against the deferred tax assets relating to jurisdictions of the federal U.S., the state of California,Japan and Singapore.A reconciliation of the beginning and ending amount of the valuation allowance for the years ended December 31, 2016, 2015 and 2014 is as follows (inthousands): Valuation AllowanceDecember 31, 2013$96,275Charges to earnings—Charges to other accounts13,892December 31, 2014110,167Charges to earnings—Charges to other accounts13,970December 31, 2015124,137Charges to earnings—Charges to other accounts22,148December 31, 2016$146,28586As of December 31, 2016 , we had net operating loss carryforwards for U.S. federal income tax purposes of $376.0 million , which expire in the years 2021through 2037, and U.S. federal research and development tax credits of $7.9 million , which expire in the years 2021 through 2037. As of December 31, 2016 , wehad net operating loss carryforwards for state income tax purposes of $186.4 million , which expire beginning in 2017 through 2037, and California research anddevelopment tax credits of $9.4 million , which do not expire. As of December 31, 2016 , we had foreign net operating loss carryforwards of $2.5 million , whichexpire in the years 2017 through 2037.On December 18, 2015, the Protecting Americans from Tax Hikes Act of 2015 was signed into law. This law establishes the permanency of U.S. researchand development credits. We recorded approximately $0.5 million which was fully offset by a valuation allowance in the current year.Utilization of the net operating loss carryforwards and credits may be subject to a substantial annual limitation due to the ownership change limitationsprovided by Section 382 of the Internal Revenue Code of 1986, as amended, and similar state provisions. The annual limitation may result in the expiration of netoperating losses and credits before utilization. In 2015, we completed a Section 382 analysis for the period from our inception in May 1999 through December 31,2015, which excluded the net operating loss carryforwards for DVS prior to the acquisition, and determined that an ownership change as defined under Section 382occurred in November 2001, which resulted in a reduction to our U.S. federal net operating losses by $1.2 million . In 2016, we performed a Section 382 analysisfor the period from January 1, 2014 through December 31, 2016 and determined that an ownership change did not occur during such period. See Note 13 for adiscussion of our Tax Benefit Preservation Plan.We have not provided for U.S. federal and state income taxes on any of our non-U.S. subsidiaries’ undistributed earnings as of December 31, 2016 , becausesuch earnings are intended to be indefinitely reinvested. If we were to distribute such earnings of $2.7 million in the form of dividends or otherwise, we may besubject to withholding taxes of approximately $46,000 . However, since such subsidiaries’ earnings are permanently reinvested, no deferred tax liabilities wereaccrued for that amount as of December 31, 2016 .Effective January 1, 2010, we obtained approval for Pioneer Tax Status in Singapore. The Pioneer Tax Status allowed a full exemption from Singaporecorporate tax related to contract manufacturing activities through the effective period subject to the achievement of certain milestones. Effective January 1, 2015,our Pioneer Tax Status was replaced by a Development and Expansion Incentive, or DEI, which provides a reduced tax rate of 5% for qualifying income inSingapore through 2019, if certain milestones are met. Due to the lower mix of genomics production activities, we expect that we will not be able to fulfill the DEImilestones. Due to available capital allowances, we have not benefited from the reduced tax rate through December 31, 2016 , and may not benefit from theincentive in future years if the incentive is withdrawn.Uncertain Tax PositionsThe aggregate changes in the balance of our gross unrecognized tax benefits during 2016 , 2015 , and 2014 were as follows (in thousands):December 31, 2013$6,848Increases in balances related to tax positions taken during current period832 Decreases in balances related to tax position taken during prior period(8)December 31, 20147,672Increases in balances related to tax positions taken during current period1,049Decreases in balances related to tax positions taken during prior period(59)December 31, 20158,662Increases in balances related to tax positions taken during a prior period46Increases in balances related to tax positions taken during current period1,673Decreases in balances related to tax positions taken during prior period(1,048)December 31, 2016$9,33387Accrued interest and penalties related to unrecognized tax benefits were included in the income tax provision and are immaterial as of December 31, 2016and 2015 .As of December 31, 2016 , there are no unrecognized tax benefits that, if recognized, would affect our effective tax rate. We do not anticipate that ourexisting unrecognized tax benefits will significantly increase or decrease within the next 12 months .We file income tax returns in the United States, various states, and certain foreign jurisdictions. As a result of net operating loss carryforwards, all of our taxyears are open to federal and state examination in the United States. Tax years from 2009 are open to examination in various foreign countries.11. Employee Benefit PlansWe sponsor a 401(k) savings plan for our employees in the United States that stipulates that eligible employees may elect to contribute to the plan, subject tocertain limitations, up to the lesser of 90% of eligible compensation or the maximum amount allowed by the U.S. Internal Revenue Service. In 2015, the Companyimplemented a match formula of 100% up to $2,000 annually, following a 4 -year vesting schedule. Employer matching contributions to the 401(k) plan for theyear ended December 31, 2016 and 2015 was $0.6 million and $0.5 million , respectively.12. Information About Geographic AreasWe operate in one reporting segment, which is the development, manufacturing, and commercialization of life science tools for the life science and Ag-Bioindustries. Our chief executive officer manages our operations and evaluates our financial performance on a consolidated basis. For purposes of allocatingresources and evaluating regional financial performance, our chief executive officer reviews separate sales information for the different regions of the world. Ourgeneral and administrative expenses and our research and development expenses are not allocated to any specific region. Most of our principal operations, otherthan manufacturing, and our decision-making functions are located at our corporate headquarters in the United States.The following table represents our total revenue by geographic area of our customers for each year presented (in thousands): Year Ended December 31, 2016 2015 2014United States $52,637 $55,404 $59,674Europe 29,739 36,772 33,045Asia-Pacific 18,478 16,967 19,810Other 3,592 5,569 3,927Total $104,446 $114,712 $116,456Our license and grant revenue is primarily generated in the United States.88We had long-lived assets consisting of property and equipment, net of accumulated depreciation, in the following geographic areas (in thousands) as of: December 31, 2016 2015 2014United States $6,145 $6,123 $5,317Singapore 6,830 8,014 7,624Canada 3,503 1,065 837Europe 43 47 75Asia-Pacific 4 9 36Total $16,525 $15,258 $13,889 Sales to customers in China represented 11% or $11.1 million , of total revenues for 2016. For the years ended December 31, 2015 and 2014, sales to Chinadid not exceed 10%.13. Shareholders' EquityOn November 21, 2016, our board of directors adopted a Tax Benefit Preservation Plan, or the tax benefit preservation plan. In connection with the adoptionof the tax benefit preservation plan, the board of directors authorized and declared a dividend distribution of one right, a Right, for each outstanding share ofcommon stock of the Company to stockholders of record as of the close of business on December 1, 2016, or the Record Date. Each Right entitles the registeredholder to purchase from the Company one one-thousandth of a share of Series A Participating Preferred Stock, par value $0.001 per share, or the Preferred Shares,of the Company at an exercise price of $35.00 per one one-thousandth of a Preferred Share, subject to adjustment. The complete terms of the Rights are set forth inthe tax benefit preservation plan. The Company expects to submit the tax benefit preservation plan to a stockholder vote at the Company’s 2017 Annual Meeting ofStockholders.By adopting the tax benefit preservation plan, the board of directors is seeking to protect our ability to use our net operating losses, any loss or deductionattributable to a “net unrealized built-in loss” and other tax attributes, or the Tax Benefits. We view the Tax Benefits as highly valuable assets that are likely toinure to the benefit of us and our stockholders. However, if we experience an “ownership change,” as defined in Section 382 of the Internal Revenue Code, or theCode, our ability to use the Tax Benefits could be substantially limited, and the timing of the usage of the tax benefits could be substantially delayed, which couldsignificantly impair the value of the Tax Benefits. Generally, an “ownership change” occurs if the percentage of our stock owned by one or more “five percentstockholders” increases by more than 50 percentage points over the lowest percentage of stock owned by such stockholders at any time during the prior three-yearperiod or, if sooner, since the last “ownership change” experienced by us. the tax benefit preservation plan is intended to deter acquisitions of 4.99% or more of theoutstanding shares of common stock by any person without the approval of the board of directors. This would protect the tax benefits because changes inownership by a person owning less than 4.99% of the shares of common stock are not included in the calculation of “ownership change” for purposes of Section382 of the Code.The Rights will expire on the earliest to occur of (i) 5:00 p.m., New York City time, on November 21, 2019 (unless such date is extended); (ii) theredemption or exchange of the Rights; (iii) following (a) the first annual meeting of the stockholders after the adoption of the tax benefit preservation plan if ourstockholders do not approve the tax benefit preservation plan or (b) the first anniversary of the adoption of the tax benefit preservation plan if our stockholdershave not otherwise approved the tax benefit preservation plan; (iv) the repeal of Section 382 of the Internal Revenue Code or any other change if our board ofdirectors determines that the tax benefit preservation plan is no longer necessary or desirable for the preservation of our net operating losses; (v) the time at whichwe determine that the Tax Benefits associated with the net operating losses either are fully utilized or no longer available pursuant to Section 382 or that anownership change pursuant to Section 382 would not adversely impact in any material respect the time period in which we could use the net operating losses ormaterially impair the amount of the net operating losses that could be used by us in any particular time period for applicable tax purposes; or (vi) a determinationby our board of directors that the tax benefit preservation plan is no longer in our best interests and the best interest of our stockholders.8914. Subsequent Events2011 Equity Incentive PlanOn January 1, 2017, 1,000,000 shares were added to the 2011 Plan share reserve pursuant to an “evergreen” provision contained in the 2011 Plan. Pursuant tosuch provision, on January 1 of each fiscal year beginning with the 2012 fiscal year, the number of shares available for issuance under the 2011 Plan isautomatically increased in an amount equal to the least of (i) 1,000,000 shares of the Company’s common stock, (ii) four percent ( 4% ) of the number of shares ofthe Company’s common stock outstanding on December 31 of the preceding fiscal year, or (iii) such number of shares of the Company’s common stockdetermined by the board of directors.2017 Inducement Award PlanOn January 5, 2017, we adopted the Fluidigm Corporation 2017 Inducement Award Plan (the “Inducement Plan”) and reserved 2,000,000 shares of theCompany’s common stock for issuance pursuant to equity awards granted under the Inducement Plan. The Inducement Plan provides for the grant of equity-basedawards, including non-statutory stock options, restricted stock units, restricted stock, stock appreciation rights, performance shares and performance units, and itsterms are substantially similar to the Company’s 2011 Equity Incentive Plan, including with respect to treatment of equity awards in the event of a “merger” or“change in control” as defined under the Inducement Plan, but with such other terms and conditions intended to comply with the NASDAQ Inducement Awardexception. In accordance with Rule 5635(c)(4) of the Nasdaq Listing Rules, awards under the Inducement Plan may only be made to individuals not previouslyemployees or non-employee directors of the Company (or following such individuals’ bona fide period of non-employment with the Company), as an inducementmaterial to the individuals’ entry into employment with the Company or in connection with a merger or acquisition, to the extent permitted by Rule 5635(c)(3) ofthe Nasdaq Listing Rules.15. Quarterly Results of Operations (Unaudited)Selected quarterly results of operations for the years ended December 31, 2016 and 2015 are as follows (in thousands, except for per share amounts): 2016 FirstQuarter SecondQuarter ThirdQuarter FourthQuarterTotal revenue $29,003 $28,168 $22,191 $25,084Net loss $(19,884) $(18,617) $(19,787) $(17,697)Net loss per share, basic and diluted $(0.69) $(0.64) $(0.68) $(0.61)2015 FirstQuarter SecondQuarter ThirdQuarter FourthQuarterTotal revenue $26,729 $28,618 $28,643 $30,722Net loss $(15,931) $(15,236) $(9,269) $(12,879)Net loss per share, basic and diluted $(0.56) $(0.53) $(0.32) $(0.45)90ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURENone.ITEM 9A. CONTROLS AND PROCEDURESEvaluation of Disclosure Controls and ProceduresOur management, with the participation of our Chief Executive Officer and our Chief Financial Officer, evaluated the effectiveness of our disclosure controlsand procedures as of December 31, 2016 . The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act,means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files orsubmits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosurecontrols and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in thereports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive andprincipal financial officers, as appropriate to allow timely decisions regarding required disclosure. Management recognizes that any controls and procedures, nomatter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment inevaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of December 31,2016 , our Chief Executive Officer and Chief Financial Officer concluded that, as of such date, our disclosure controls and procedures were effective at thereasonable assurance level.Management’s Report on Internal Control Over Financial ReportingOur management is responsible for establishing and maintaining adequate internal control over financial reporting (as such term is defined in Exchange ActRule 13a-15f) to provide reasonable assurance regarding the reliability of our financial reporting and the preparation of financial statements for external purposesin accordance with generally accepted accounting principles. Management assessed our internal control over financial reporting as of December 31, 2016 .Management based its assessment on criteria established in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of theTreadway Commission (2013 Framework). Based on that evaluation, our management concluded that our internal control over financial reporting was effective asof December 31, 2016 .The effectiveness of our internal control over financial reporting as of December 31, 2016 has been audited by PricewaterhouseCoopers, LLP, anindependent registered public accounting firm, as stated in their report included in this Annual Report on Form 10-K.Changes in Internal Control Over Financial ReportingThere were no changes in our internal control over financial reporting that occurred during the three months ended December 31, 2016 that have materiallyaffected, or are reasonably likely to materially affect, our internal control over financial reporting.Inherent Limitations on the Effectiveness of ControlsControl systems, no matter how well conceived and operated, are designed to provide a reasonable, but not an absolute, level of assurance that the objectivesof the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must beconsidered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all controlissues and instances of fraud, if any, have been detected. Because of the inherent limitations in any control system, misstatements due to error or fraud may occurand not be detected. ITEM 9B. OTHER INFORMATIONNot applicable. 91PART IIIITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCEPursuant to General Instruction G(3) of Form 10-K, the information required by this Item 10 relating to our executive officers is included under the caption“Executive Officers” in Part I of this Form 10-K.The other information required by this Item 10 will be included either (i) in an amendment to this Annual Report on Form 10-K or (ii) incorporated byreference to our Proxy Statement for the 2017 Annual Meeting of Stockholders under the headings “Corporate Governance and Board of Directors,” “Election ofClass I Directors,” “Executive Officers,” and “Related Person Transactions and Section 16(a) Beneficial Ownership Reporting Compliance.” Such amendment toour Form 10-K or Proxy Statement for our 2017 Annual Meeting of Stockholders will be filed with the Securities and Exchange Commission within 120 days ofour December 31, 2016 fiscal year end. ITEM 11. EXECUTIVE COMPENSATIONThe information required by this Item 11 will be included either (i) in an amendment to this Annual Report on Form 10-K or (ii) incorporated by reference toour Proxy Statement for the 2017 Annual Meeting of Stockholders under the headings “Corporate Governance and Board of Directors” and “ExecutiveCompensation.” Such amendment to our Form 10-K or Proxy Statement for our 2017 Annual Meeting of Stockholders will be filed with the Securities andExchange Commission within 120 days of our December 31, 2016 fiscal year end. ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERSThe information required by this Item 12 will be included either (i) in an amendment to this Annual Report on Form 10-K or (ii) incorporated by reference toour Proxy Statement for the 2017 Annual Meeting of Stockholders under the headings “Executive Compensation” and “Security Ownership.” Such amendment toour Form 10-K or Proxy Statement for our 2017 Annual Meeting of Stockholders will be filed with the Securities and Exchange Commission within 120 days ofour December 31, 2016 fiscal year end. ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCEThe information required by this Item 13 will be included either (i) in an amendment to this Annual Report on Form 10-K or (ii) incorporated by reference toour Proxy Statement for the 2017 Annual Meeting of Stockholders under the headings “Corporate Governance and Board of Directors” and “Related PersonTransactions and Section 16(a) Beneficial Ownership Reporting Compliance.” Such amendment to our Form 10-K or Proxy Statement for our 2017 AnnualMeeting of Stockholders will be filed with the Securities and Exchange Commission within 120 days of our December 31, 2016 fiscal year end.ITEM 14. PRINCIPAL ACCOUNTING FEES AND SERVICESThe information required by this Item 14 will be included either (i) in an amendment to this Annual Report on Form 10-K or (ii) incorporated by reference toour Proxy Statement for the 2017 Annual Meeting of Stockholders under the heading “Ratification of Appointment of Independent Registered Public AccountingFirm.” Such amendment to our Form 10-K or Proxy Statement for our 2017 Annual Meeting of Stockholders will be filed with the Securities and ExchangeCommission within 120 days of our December 31, 2016 fiscal year end. 92PART IVITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES1. Financial Statements. See “Index to Consolidated Financial Statements” in Part II, Item 8 of this Form 10-K.2. Financial Statement schedule. See “Schedule II—Valuation and Qualifying Account and Reserve” in this section of this Form 10-K.3. Exhibits. The exhibits listed in the accompanying Index to Exhibits are filed herewith or are incorporated by reference to exhibits previously filed with the U.S.Securities and Exchange Commission.93SCHEDULE II—VALUATION AND QUALIFYING ACCOUNTS AND RESERVES In thousands Balance atBeginning ofPeriod Additions/Charged toExpense Deductions Balance atEnd ofPeriodYear ended December 31, 2016 Accounts receivable allowance $103 $484 $(85) $502Year ended December 31, 2015 Accounts receivable allowance $120 $23 $(40) $103Year ended December 31, 2014 Accounts receivable allowance $36 $103 $(19) $120 In thousands Balance atBeginning ofPeriod Additions/Charged toExpense Deductions Balance atEnd ofPeriodYear ended December 31, 2016 Warranty allowance $1,076 $885 $(938) $1,023Year ended December 31, 2015 Warranty allowance $1,178 $672 $(774) $1,076Year ended December 31, 2014 Warranty allowance $344 $2,089 $(1,255) $1,17894SIGNATURESPursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on itsbehalf by the undersigned, thereunto duly authorized. FLUIDIGM CORPORATION Dated: March 2, 2017By: /s/ Stephen Christopher Linthwaite Stephen Christopher Linthwaite President and Chief Executive OfficerPOWER OF ATTORNEYKNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Stephen Christopher Linthwaiteand Vikram Jog, jointly and severally, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or herand in his or her name, place and stead, in any and all capacities, to sign this Form 10-K, and to file the same, with all exhibits thereto, and other documents inconnection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and performeach and every act and thing requisite or necessary to be done in and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agents,or his or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrantand in the capacities and on the dates indicated. Signature Title Date /s/ Stephen Christopher Linthwaite President and Chief Executive Officer (Principal ExecutiveOfficer); Director March 2, 2017Stephen Christopher Linthwaite /s/ Vikram Jog Chief Financial Officer (Principal Financial Officer) March 2, 2017Vikram Jog /s/ Jennifer Lee Vice President, Controller (Principal Accounting Officer) March 2, 2017Jennifer Lee /s/ Samuel D. Colella Chairman of the Board of Directors March 2, 2017Samuel D. Colella /s/ Gerhard F. Burbach Director March 2, 2017Gerhard F. Burbach /s/ Evan Jones Director March 2, 2017Evan Jones /s/ Patrick S. Jones Director March 2, 2017Patrick S. Jones /s/ John A. Young Director March 2, 2017John A. Young 95INDEX TO EXHIBITSExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed2.1 Agreement and Plan of Merger dated January 28, 2014 by andamong Fluidigm Corporation, DVS Sciences, Inc., Dawid MergerSub, Inc. and Shareholder Representative Services LLC. 8-K 2.1 1/29/20143.1 Eighth Amended and Restated Certificate of Incorporation ofFluidigm Corporation filed on February 15, 2011. 10-K 3.1 3/28/20113.2 Amended and Restated Bylaws of Fluidigm Corporation effective asof February 9, 2011. 10-K 3.2 3/28/20113.3 Certificate of Designation of Rights, Preferences and Privileges ofSeries A Participating Preferred Stock. 8-K 3.1 11/22/20164.1 Specimen Common Stock Certificate of Fluidigm Corporation. S-8 4.1 1/13/20174.2 Indenture, dated February 4, 2014, by and between FluidigmCorporation and U.S. Bank National Association. 8-K 4.1 2/4/20144.3 First Supplemental Indenture, dated February 4, 2014, by andbetween Fluidigm Corporation and U.S. Bank National Association. 8-K 4.2 2/4/20144.4 Form of Global Note (included in Exhibit 4.3). 8-K 4.3 2/4/20144.5 Reserved. 4.6 Tax Benefit Preservation Plan, dated as of November 21, 2016, byand between Fluidigm Corporation and Computershare Inc., asRights Agent. 8-K 4.1 11/22/201610.1 Form of Indemnification Agreement between Fluidigm Corporationand its directors and officers. S-1/A 10.1 1/28/201110.2# 1999 Stock Option Plan of Fluidigm Corporation, as amended. S-1 10.2 12/3/201010.2A# Forms of agreements under the 1999 Stock Option Plan. S-1 10.2A 12/3/201010.3# 2009 Equity Incentive Plan of Fluidigm Corporation, as amended. S-1 10.3 12/3/201010.3A# Forms of agreements under the 2009 Equity Incentive Plan. S-1 10.3A 12/3/201010.4# 2011 Equity Incentive Plan of Fluidigm Corporation. S-1/A 10.4 1/28/201196ExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed10.4A# Forms of agreements under the 2011 Equity Incentive Plan. S-1/A 10.4A 1/28/201110.5† Second Amended and Restated License Agreement by and betweenCalifornia Institute of Technology and Fluidigm Corporation,effective as of May 1, 2004. S-1 10.5 12/3/201010.5A† First Addendum, effective as of March 29, 2007, to SecondAmended and Restated License Agreement by and betweenCalifornia Institute of Technology and Fluidigm Corporationeffective as of May 1, 2004. S-1 10.5A 12/3/201010.6† Co-Exclusive License Agreement between President and Fellows ofHarvard College and Fluidigm Corporation effective as ofOctober 15, 2000. S-1 10.6 12/3/201010.6A† First Amendment to Co-Exclusive License Agreement betweenPresident and Fellows of Harvard College and Fluidigm Corporationeffective as of October 15, 2000. S-1 10.6A 12/3/201010.7† Co-Exclusive License Agreement between President and Fellows ofHarvard College and Fluidigm Corporation effective as ofOctober 15, 2000. S-1 10.7 12/3/201010.8† Co-Exclusive License Agreement between President and Fellows ofHarvard College and Fluidigm Corporation effective as ofOctober 15, 2000. S-1 10.8 12/3/201010.9† Letter Agreement between President and Fellows of Harvard Collegeand Fluidigm Corporation dated December 22, 2004. S-1 10.9 12/3/201010.10# Fluidigm Corporation 2017 Inducement Award Plan and relatedform agreements. 8-K 10.1 1/11/201710.11# Offer Letter to Jennifer Lee date March 30, 2016. 8-K 10.1 5/23/201610.12 Reserved. 10.13# Amended and Restated Offer Letter to Steven C. McPhail, datedFebruary 28, 2017. Filed herewith 10.14# Form of Amended and Restated Employment and SeveranceAgreement between Fluidigm Corporation and each of its executiveofficers. 8-K 10.14 12/11/201210.15#† Offer Letter to Stephen Christopher Linthwaite, dated July 14, 2016. 10-Q 10.1 11/9/201610.16# Employment and Severance Agreement, effective as of August 1,2016, by and between Fluidigm Corporation and StephenChristopher Linthwaite 10-Q 10.2 11/9/201610.17# Offer Letter to Vikram Jog dated January 29, 2008. S-1 10.17 12/3/201010.18# Offer Letter dated May 3, 2010 to Fredric Walder and Addendumthereto dated November 8, 2010. 8-K 10.18 4/4/201110.19 Lease Agreement between ARE - San Francisco No. 17 LLC andFluidigm Corporation, dated September 14, 2010, as amendedSeptember 22, 2010. S-1/A 10.19 1/7/201110.19A Second Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated April 9,2013. 10-Q 10.19A 5/9/201310.19B Fourth Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated June 4,2014. 10-Q 10.3 8/4/201497ExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed10.19C Fifth Amendment to Lease Agreement between ARE-San FranciscoNo. 17, LLC and Fluidigm Corporation, dated September 15, 2014. 10-Q 10.2 11/6/201410.19D Sixth Amendment to Lease Agreement between ARE-San FranciscoNo. 17, LLC and Fluidigm Corporation, dated December 8, 2015. 8-K 10.1 12/14/201510.20 Tenancy for Flatted Factory Space in Singapore between JTCCorporation and Fluidigm Corporation dated July 27, 2005, asamended August 12, 2008 and May 31, 2010. S-1 10.20 12/3/201010.21 Offer of Tenancy for Facility Lease between Fluidigm SingaporePte. Ltd. and SBC Institutional Trust Services (Singapore) Limited,as trustee of Ascendas Real Estate Investment Trust dated October14, 2013. 10-K 10.21 3/12/201410.22 Offer of Tenancy for Lease of Additional Space at Singapore Facilitybetween Fluidigm Singapore Pte. Ltd. and HSBC Institutional TrustServices (Singapore) Limited, as trustee of Ascendas Real EstateInvestment Trust, dated April 2, 2015. 10-Q 10.1 8/10/201510.23† Office Lease by and among Rodick Equities Inc., Fluidigm CanadaInc., and Fluidigm Corporation, dated August 17, 2015. 10-Q 10.1 11/9/201510.24# Form of Award Agreement for purposes of the Retention Program. 8-K 10.1 2/10/201610.25# Executive Bonus Plan. 10-K 10.25 3/28/201110.26# Letter Agreement between Fluidigm Corporation and William M.Smith, Fluidigm Corporation's Executive Vice President of LegalAffairs and General Counsel, dated March 4, 2014. 10-Q 10.2 5/12/201410.27† License Agreement between MDS Analytical Technologies, abusiness unit of MDS INC., and DVS Sciences Inc., dated July 17,2008. 10-Q/A 10.3 9/15/201410.28† Sublicense Agreement between DVS Sciences Inc. and FluidigmCorporation, dated January 28, 2014. 10-Q/A 10.4 9/15/201410.29# Separation Agreement and Release between Gajus V. Worthingtonand Fluidigm Corporation dated October 19, 2016. 8-K 99.1 10/24/201612.1 Computation of ratio of earnings to combined fixed charges andpreference dividends. Filed herewith 21.1 Subsidiaries of Fluidigm Corporation. Filed herewith 23.1 Consent of PricewaterhouseCoopers LLP, Independent RegisteredPublic Accounting Firm. Filed herewith 23.2 Consent of Ernst & Young LLP, Independent Registered PublicAccounting Firm. Filed herewith 24.1 Power of Attorney (contained in the signature page to this Form 10-K). Filed herewith 31.1 Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 302 of the Sarbanes-Oxley Act of 2002 of ChiefExecutive Officer. Filed herewith 31.2 Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 302 of the Sarbanes-Oxley Act of 2002 of ChiefFinancial Officer. Filed herewith 32.1~ Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 906 of the Sarbanes-Oxley Act of 2002 of ChiefExecutive Officer. Filed herewith 98ExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed32.2~ Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 906 of the Sarbanes-Oxley Act of 2002 of ChiefExecutive Officer. Filed herewith 101.INS XBRL Instance Document Filed herewith 101.SCH XBRL Taxonomy Extension Schema Document Filed herewith 101.CAL XBRL Taxonomy Extension Calculation Linkbase Document Filed herewith 101.DEF XBRL Taxonomy Extension Definition Linkbase Document Filed herewith 101.LAB XBRL Taxonomy Extension Label Document Filed herewith 101.PRE XBRL Taxonomy Extension Presentation Document Filed herewith # Management contracts or compensation plans or arrangements in which directors or executive officers are eligible to participate.† Portions of the exhibit have been omitted pursuant to an order granted by the Securities and Exchange Commission for confidential treatment.~ In accordance with Item 601(b)(32)(ii) of Regulation S-K and SEC Release No. 33-8238 and 34-47986, Final Rule: Management’s Reports on Internal ControlOver Financial Reporting and Certification of Disclosure in Exchange Act Periodic Reports, the certifications furnished in Exhibits 32.1 and 32.2 hereto aredeemed to accompany this Form 10-K and will not be deemed “filed” for purposes of Section 18 of the Exchange Act. Such certifications will not be deemed tobe incorporated by reference into any filings under the Securities Act or the Exchange Act, except to the extent that Fluidigm Corporation specificallyincorporates it by reference.99 Exhibit 10.13February 28, 2017Steven C. McPhailDear Steve:This updated terms of employment letter supersedes and replaces your prior offer letter, dated April 1, 2015. As of the date hereof, you are servingas Chief Commercial Officer of Fluidigm Corporation (“Fluidigm” or the “Company”), reporting directly to the Chief Executive Officers. Other terms ofemployment include:Compensation:Your current annual base salary is $339,700, which will be paid, less any deductions required by applicable law, in accordance with the Company’snormal payroll procedures. The Company is on a semi-monthly pay schedule with two pay periods per calendar month which generally fall on the 15th and the last day of the month. This is an exempt position.Executive Bonus Plan:You will be eligible to participate in the Company’s Executive Corporate Bonus Plan which is based on achievement of targets or performancecriteria as may be specified by your management and the Board. The terms and conditions of the Bonus Plan may be amended or varied from timeto time at the sole discretion of the Board. Your target bonus is currently 42.5% of your annual base salary, subject to all applicable federal and statetaxes, which, if and to the extent earned, is typically paid out following the end of the applicable bonus year.Equity Award:As you know, you have been granted certain equity awards under the Company equity incentive plan; such outstanding awards remain subject tothe terms of the plan and the relevant grant documents. You may be eligible, subject to approval by the Company’s Board of Directors or itsCompensation Committee, for further awards depending on performance and other considerations in the discretion of the Company.Benefits:You are eligible to receive the Company’s standard benefits package which includes medical, dental, vision, life and disability insurance benefits.Benefits will be effective the first day of the month following your date of hire or upon a qualifying event. Additional benefits, as the Company maymake generally available to its employees from time to time, will be made available to you. You are entitled to three (3) weeks paid vacation eachyear and such paid holidays as the Company gives to its employees generally.Workers’ Compensation Insurance:The Company provides a comprehensive workers’ compensation insurance program at no cost to employees. This program covers any injury orillness sustained in the course of employment that requires medical, surgical or hospital treatment. Insurance carrier: Preferred Employers Group -PO BOX 85838, San Diego, CA 92186, phone number (866) 472-9602.1 Confidentiality and Company Policies:You have executed the Company’s standard At-Will Employment, Confidential Information, Invention Assignment, and Arbitration Agreement, whichcontinues to be in effect.Employment and Severance Agreement:As an executive officer of the Company and subject to approval by the Board (or a committee authorized by the Board), you and the Company haveentered into the Company’s Employment and Severance Agreement. A copy of the current form of such agreement as entered between theCompany and each of its executive officers has been provided to you separately.Other:This letter shall be interpreted under California law. You should be aware that your employment with the Company is for no specified period andconstitutes “at will” employment. As a result, you are free to resign at any time, for any reason or for no reason. Similarly, the Company is free toconclude its employment relationship with you at any time, with or without cause. In addition, the Company may change your compensation, duties,assignments, responsibilities, location of your position, or any other terms and conditions of employment at any time to adjust to the changing needsof our dynamic Company.In the event of any dispute or claim relating to or arising out of our employment relationship, you and the Company agree that all such disputes shallbe fully and finally resolved by binding arbitration conducted by the Judicial Arbitration & Mediation Services (“JAMS”) in Santa Clara CountyCalifornia. The current JAMS employment arbitration rules & procedures can be found at http://www.jamsadr.com/rules-employment-arbitration / . The JAMS employment arbitration rules & procedures may, however, be amended by JAMS.) You acknowledge that you are waiving your right to ajury trial.Our employees are committed to the success and growth of our business. At Fluidigm, we believe that our values are not just words on paper –they are a statement of our character. Fluidigmers should: Win as a team; Work hard and with passion; Be strong; Be aggressive; Do what you sayyou will do; Sweat the details; and Keep learning. We believe our values define who we are as a company and as employees of Fluidigm. Weaspire to live by these values each day and work hard to exhibit these traits because these are the things that are worth believing. Thank you foryour continued dedication to Fluidigm; I look forward to our mutual success in growing the Company. 2 Sincerely, /s/ S. Christopher Linthwaite S. Christopher Linthwaite President and CEO Fluidigm Corporation ACCEPTED AND AGREED TO: /s/ Steven C. McPhail February 28, 2017Steven C. McPhail Date3Exhibit 12.1Fluidigm CorporationRatio of earnings to fixed chargesFiscal Years 2012 through 2016 Years Ended December 31, 2012 December 31, 2013 December 31, 2014 December 31, 2015 December 31, 2016(In thousands) Earnings: Net loss attributed to commonstockholders before incometaxes $(18,888) $(16,389) $(57,705) $(54,790) $(80,177)Add: Combined fixed charges andpreference dividends 1,006 1,169 7,081 8,353 8,971Less: Capitalized interest — — — — — Total earnings for computation of ratio (17,882) (15,220) (50,624) (46,437) (71,206)Fixed Charges: Interest expense includingcapitalized interest 628 14 5,344 5,808 5,820Estimated interest component ofrent 378 1,155 1,737 2,545 3,151 Total fixed charges 1,006 1,169 7,081 8,353 8,971Combined fixed charges and preferencedividends: Interest expense includingcapitalized interest 628 14 5,344 5,808 5,820Estimated interest component ofrent 378 1,155 1,737 2,545 3,151Deemed dividend — — — — — Total combined fixed charges andpreference dividends $1,006 $1,169 $7,081 $8,353 $8,971Ratio of earnings to fixed charges (1) — — — — —Ratio of earnings to combined fixedcharges and preference dividends (1) — — — — — (1) Earnings for the years ended December 31, 2012, 2013, 2014, 2015 and 2016 were insufficient to cover fixed charges by $18.9 million, $16.4 million, $57.7million, $54.8 million and $80.2 million, respectively.For the purpose of calculating the ratio of earnings to fixed charges, earnings consist of net loss before benefit from income taxes. Fixed charges consist ofinterest expense and an estimate of the interest portion of rental expense. In addition, for the periods presented above, we did not have outstanding preferredsecurities and therefore were not required to pay any preferred security dividends.Exhibit 21.1SUBSIDIARIES OF FLUIDIGM CORPORATION Subsidiaries of Fluidigm Corporation (Delaware): Fluidigm K.K. (Japan) Fluidigm Europe, B.V. (Netherlands) Fluidigm Singapore Pte. Ltd. (Singapore) Fluidigm (Shanghai) Instrument Technology Company Limited (China) Fluidigm Sciences Inc. (Delaware) Subsidiaries of Fluidigm Europe, BV (Netherlands): Fluidigm France SARL (France) Fluidigm UK Limited (United Kingdom) Fluidigm GmbH (Germany) Subsidiaries of Fluidigm Sciences Inc. (Delaware): Fluidigm Canada Inc. (Ontario, Canada) Exhibit 23.1CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMWe hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No.333-172206, 333-180363, 333-187204, 333-202325, 333-209904 and 333-215555), Form S-8 POS (No.333-209904), and Form S-3/S-8 (No. 333-194084), of Fluidigm Corporation of our report dated March 2, 2017relating to the financial statements , financial statement schedule, and the effectiveness of internal control over financial reporting, which appears in this Form 10-K. /s/ PricewaterhouseCoopers LLPSan Jose, CaliforniaMarch 2, 2017Exhibit 23.2CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMWe consent to the incorporation by reference in the following Registration Statements:(1) Registration Statements (Form S-8 Nos. 333-172206, 333-180363, 333-187204, 333-202325, 333-209904 (as amended) and 333-215555) pertaining to the1999 Stock Option Plan, 2009 Equity Incentive Plan, 2011 Equity Incentive Plan, 2017 Inducement Award Plan of Fluidigm Corporation, and(2) Registration Statement (Form S-8/S-3 No. 333-194084) pertaining to (a) the 2011 Equity Incentive Plan of Fluidigm Corporation, (b) stock options grantedunder the DVS Sciences, Inc. 2010 Equity Incentive Plan, as amended, assumed by Fluidigm Corporation, and (c) the DVS Sciences, Inc. Stock RestrictionAgreements and Restricted Stock Purchase Agreements assumed by Fluidigm Corporation;of our report dated February 29, 2016, with respect to the consolidated financial statements of Fluidigm Corporation of Fluidigm Corporation included in thisAnnual Report (Form 10-K) of Fluidigm Corporation for the year ended December 31, 2016./s/ Ernst & Young LLP Redwood City, CAMarch 2, 2017Exhibit 31.1CERTIFICATION OF THE PRESIDENT AND CHIEF EXECUTIVE OFFICERPURSUANT TO SECURITIES EXCHANGE ACT RULES 13a-14(a) AND 15d-14(a),AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Stephen Christopher Linthwaite, certify that:1.I have reviewed this annual report on Form 10-K of Fluidigm Corporation;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to makethe statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered bythis report;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respectsthe financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and15d-15(f)) for the registrant and have:a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, toensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others withinthose entities, particularly during the period in which this report is being prepared;b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under oursupervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statementsfor external purposes in accordance with generally accepted accounting principles;c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recentfiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely tomaterially affect, the registrant’s internal control over financial reporting; and5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to theregistrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internalcontrol over financial reporting.Date: March 2, 2017 By: /s/ Stephen Christopher Linthwaite Stephen Christopher Linthwaite President and Chief Executive OfficerExhibit 31.2CERTIFICATION OF THE CHIEF FINANCIAL OFFICERPURSUANT TO SECURITIES EXCHANGE ACT RULES 13a-14(a) AND 15d-14(a),AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Vikram Jog, certify that:1.I have reviewed this annual report on Form 10-K of Fluidigm Corporation;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to makethe statements made, in light of the circumstances under which such statements were made, not misleading with respect to the periodcovered by this report;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respectsthe financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f)and 15d-15(f)) for the registrant and have:a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under oursupervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to usby others within those entities, particularly during the period in which this report is being prepared;b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed underour supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financialstatements for external purposes in accordance with generally accepted accounting principles;c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s mostrecent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonablylikely to materially affect, the registrant’s internal control over financial reporting; and5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, tothe registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’sinternal control over financial reporting. Date: March 2, 2017 By: /s/ Vikram Jog Vikram Jog Chief Financial OfficerExhibit 32.1CERTIFICATION OF CHIEF EXECUTIVE OFFICERPURSUANT TO 18 U.S.C. § 1350, AS ADOPTED PURSUANT TO SECTION 906OF THE SARBANES-OXLEY ACT OF 2002I, Stephen Christopher Linthwaite, the chief executive officer of Fluidigm Corporation (the “Company”), certify for the purposes of 18 U.S.C. Section 1350,as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,(i) the Annual Report of the Company on Form 10-K for the fiscal year ended December 31, 2016 (the “Report”), fully complies with therequirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. By:/s/ Stephen Christopher Linthwaite Stephen Christopher Linthwaite President and Chief Executive Officer Date: March 2, 2017Exhibit 32.2CERTIFICATION OF CHIEF FINANCIAL OFFICERPURSUANT TO 18 U.S.C. § 1350, AS ADOPTED PURSUANT TO SECTION 906OF THE SARBANES-OXLEY ACT OF 2002I, Vikram Jog, the chief financial officer of Fluidigm Corporation (the “Company”), certify for the purposes of 18 U.S.C. Section 1350, as adopted pursuantto Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,(i) the Annual Report of the Company on Form 10-K for the fiscal year ended December 31, 2016 (the “Report”), fully complies with therequirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. By:/s/ Vikram Jog Vikram Jog Chief Financial Officer Date: March 2, 2017

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