Fluidigm Corporation
Annual Report 2018

Plain-text annual report

UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549______________________________________FORM 10-K(Mark One)x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2018or¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934_____________________________________________Commission file number: 001-34180FLUIDIGM CORPORATION(Exact name of registrant as specified in its charter)Delaware 77-0513190(State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number)7000 Shoreline Court, Suite 100, South San Francisco, California 94080(Address of principal executive offices) (Zip Code)Registrant’s telephone number, including area code: (650) 266-6000_____________________________________________Securities registered pursuant to Section 12(b) of the Act:Title of each class Name of each exchange on which registeredCommon Stock, $0.001 Par Value per Share The Nasdaq Global Select MarketSecurities registered pursuant to Section 12(g) of the Act:None_____________________________________________Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act of 1933, as amended. Yes xNo ¨Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934, asamended. Yes ¨ No xIndicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filingrequirements for the past 90 days. Yes x No ¨Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 ofRegulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes x No ¨Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to thebest of the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment tothis Form 10-K. xIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or anemerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and "emerging growth company"in Rule 12b-2 of the Exchange Act. Large accelerated filer ¨Accelerated filer x Non-accelerated filer ¨ Smaller reporting company x Emerging growth company ¨If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with anynew or revised financial accounting standards provided, pursuant to Section 13(a) of the Exchange Act. ¨Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨ No xAs of June 30, 2018, the aggregate market value of voting and non-voting common equity held by non-affiliates of the registrant was approximately$151,752,358, based on the closing sale price on that date. Shares of common stock held by each executive officer and director and by each other person whomay be deemed to be an affiliate of the Registrant have been excluded from this computation. The determination of affiliate status for this purpose is notnecessarily a conclusive determination for other purposes.As of March 13, 2019, there were 68,989,239 shares of the registrant’s common stock outstanding.DOCUMENTS INCORPORATED BY REFERENCEPortions of the registrant’s Proxy Statement in connection with the registrant’s annual meeting of stockholders, scheduled to be held in June 2019, areincorporated by reference in Part III of this report. Except as expressly incorporated by reference, the registrant’s Proxy Statement shall not be deemed to bepart of this report.Fluidigm CorporationFiscal Year 2018Form 10-KAnnual Report______________________________________TABLE OF CONTENTS PagePART I ITEM 1. BUSINESS 1ITEM 1A. RISK FACTORS 13ITEM 1B. UNRESOLVED STAFF COMMENTS 38ITEM 2. PROPERTIES 38ITEM 3. LEGAL PROCEEDINGS 38ITEM 4. MINE SAFETY DISCLOSURES 38 PART II ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS ANDISSUER PURCHASES OF EQUITY SECURITIES 39ITEM 6. SELECTED FINANCIAL DATA 40ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OFOPERATIONS 41ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK 56ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA 57ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIALDISCLOSURE 92ITEM 9A. CONTROLS AND PROCEDURES 92ITEM 9B. OTHER INFORMATION 93 PART III ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE 94ITEM 11. EXECUTIVE COMPENSATION 94ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATEDSTOCKHOLDER MATTERS 94ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE 94ITEM 14. PRINCIPAL ACCOUNTING FEES AND SERVICES 94 PART IV ITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES 95ITEM 16. FORM 10-K SUMMARY 97 INDEX TO EXHIBITS SIGNATURES iSpecial Note Regarding Forward-looking Statements and Industry DataThis Form 10-K contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, or Securities Act,and Section 21E of the Securities Exchange Act of 1934, as amended, or Exchange Act, that are based on our management’s beliefs and assumptions and oninformation currently available to our management. The forward-looking statements are contained principally in the sections entitled “Business,” “Riskfactors,” and “Management’s discussion and analysis of financial condition and results of operations.” Forward-looking statements include informationconcerning our possible or assumed future cash flow, revenue, sources of revenue and results of operations, cost of product revenue and product margin,operating and other expenses, unit sales and the selling prices of our products, business strategies, financing plans, expansion of our business, competitiveposition, industry environment, potential growth opportunities, market growth expectations, and the effects of competition. Forward-looking statementsinclude statements that are not historical facts and can be identified by terms such as “anticipates,” “believes,” “could,” “seeks,” “estimates,” “expects,”“intends,” “may,” “plans,” “potential,” “predicts, “projects,” “should,” “will,” “would,” or similar expressions and the negatives of those terms.Forward-looking statements involve known and unknown risks, uncertainties, and other factors that may cause our actual results, performance, orachievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Wediscuss these risks in greater detail in the section entitled “Risk factors” and elsewhere in this Form 10-K. Given these uncertainties, you should not placeundue reliance on these forward-looking statements.Forward-looking statements represent our management’s beliefs and assumptions only as of the date of this Form 10-K. Except as required by law, weassume no obligation to update these forward-looking statements, or to update the reasons actual results could differ materially from those anticipated inthese forward-looking statements, even if new information becomes available in the future. You should read this Form 10-K completely and with theunderstanding that our actual future results may be materially different from what we expect.____________________________“Fluidigm,” the Fluidigm logo, “Access Array,” “Advanta,” “Biomark,” “C1,” “Callisto,” “CyTOF,” “Delta Gene,” “Digital Array,” “Dynamic Array,”“EP1,” “Flex Six,” “Helios,” “Hyperion,” “Imaging Mass Cytometry,” “IMC,” “Juno,” “Maxpar,” “MSL,” “Polaris,” “Script Builder,” “Singular,” and “SNPType” are trademarks or registered trademarks of Fluidigm Corporation. Other service marks, trademarks and trade names referred to in this Form 10-K are theproperty of their respective owners.____________________________Unless the context requires otherwise, references in this Annual Report on Form 10-K to “Fluidigm,” the “Company,” “we,” “us,” and “our” refer toFluidigm Corporation and its subsidiaries.PART IITEM 1. BUSINESSOverviewFluidigm is a global company that improves life through comprehensive health insight. Our innovative technologies and multi-omic tools are used byresearchers to reveal meaningful insights into health and disease, identify biomarkers to inform decisions, and accelerate the development of more effectivetherapies. We create, manufacture, and market a range of products and services, including instruments, reagents and software that are used by researchersworldwide.Our focus is on the most pressing needs in translational and clinical research, including cancer, immunology and immunotherapy. We use proprietaryCyTOF® and microfluidics technologies to develop innovative end-to-end solutions that have the flexibility required to meet the needs of translationalresearch and the robustness to support high-impact clinical research studies.Our mass cytometry Helios™ system deeply profiles cell phenotype and function. Referenced by hundreds of peer-reviewed publications around theworld, mass cytometry is setting a new standard in human immune profiling. Transforming biological imaging, our Hyperion™ Imaging System enableshighly multiplexed protein biomarker detection in tissues and tumors while still preserving tissue architecture and cellular morphology information usingImaging Mass Cytometry™ (IMC™). Our microfluidic systems complement our mass cytometry offerings by providing highly scalable and automatedworkflows for quantitative polymerase chain reaction, or PCR, gene expression, copy number variation analysis, and next-generation sequencing librarypreparation. Used to detect somatic and genomic variations from a range of different sample types, these automated systems provide the cost efficiencies,flexibility and proven analytical performance that customers need to meet the increasing demands of molecular biomarker analysis.We are a trusted partner of leading academic, government, pharmaceutical, biotechnology, and plant and animal research laboratories worldwide and westrive to increase the quality of life for all.Market OpportunityThe current markets for our products address a broad range of biological analysis approaches, including the genome, proteome, transcriptome,epigenomics and microbiome used by academic life science research customers, as well as applied markets customers, including clinical research laboratories,biopharmaceutical companies, biorepositories and agricultural biotechnology entities. Our markets are increasingly looking to study data sets across theseapproaches in a concerted manner to answer pressing questions about immune function across cancer, immunology and immunotherapy.StrategyKey elements of our strategy include:Offering innovative, differentiated products to researchers based on our mass cytometry and microfluidic technologies.•Mass cytometry is a leading solution to analyze many cell-surface and intracellular proteins simultaneously in cell suspensions including blood anddisassociated tissues. Our products enable innovative methods to characterize cells and other sample types not commonly achieved with otherconventional technologies.•Imaging Mass Cytometry is a pioneering technology allowing for high multiplexed imaging to understand the composition of tissuemicroenvironments at a subcellular resolution.•Our microfluidic technologies enable a scalable and sensitive solution in fields requiring high-throughput molecular biomarker analysis, whether itbe for the analysis of gene expression profiles, genotyping or library preparation in advance of gene sequencing. Microfluidic solutions also enablesingle-cell genomic analysis across a broad menu of applications.1Expanding addressable markets through attention to assay content, workflow efficiency, software improvements, desirable strategic partnerships andinorganic growth opportunities.Our strategy addresses expanded and enhanced applications, workflows and analytics to allow our customers better productivity, increasing the valueof our toolsets across our mass cytometry and microfluidics products.•We have developed a new workflow for comprehensive human immune monitoring for use with our Helios system, as well as application, sampleprotocol, antibodies and reagents that researchers use to design their own experiments. We have collaborated with industry partners to enableworkflows and software for both the Helios and Hyperion systems.•We have developed and collaborated with industry partners to build our applications, software and assays on our microfluidic platforms for geneexpression, genotyping and sequencing library preparations as well as single-cell applications for our C1 system. Our future development willleverage both in-house informatics as well as externally-partnered solutions to drive towards sample-to-answer functionality across all our platforms.ProductsWe market innovative technologies and life science tools, including preparatory and analytical instruments for Mass Cytometry, PCR, Library Prep,Single Cell Genomics, and consumables, including integrated fluidic circuits (IFCs), assays, and reagents. Our primary product offerings are summarized inthe table below:Product Product Description ApplicationsMass Cytometry Analytical Systems: Helios™, a CyTOF system The Helios mass cytometry system performs high-parameter single-cell analysis using antibodiesconjugated to metal isotopes. Mass Cytometry Hyperion™ Imaging System The Hyperion Imaging System brings together imagingcapability with proven high-parameter CyTOFtechnology to enable the simultaneous detection of upto 37 protein markers in the spatial context of the tissuemicroenvironment. Imaging Mass Cytometry Hyperion™ Tissue Imager The Hyperion Tissue Imager scans tissues at 1 micronresolution. It can be purchased as an upgrade for theHelios system to enable imaging capability, thenreferred to as Hyperion Imaging System. Imaging Mass Cytometry Assays and Reagents: Maxpar® Reagents Maxpar® reagents are included in multiple productlines addressing needs in functional and phenotypicprofiling of single cells, as well as nucleic aciddetection. The product lines include pre-conjugatedantibodies, application specific kits, and customantibody labeling services. Mass Cytometry and Imaging MassCytometry. Maxpar Human Immune Monitoring Panel Kit and Workflow The kit contains 29 pre-titrated antibodies designedand optimized for deep immune profiling of humanperipheral blood mononuclear cells. Enablescomprehensive identification and characterization ofkey immune cell populations. The workflow includesprotocol and data analysis. Mass Cytometry 2Product Product Description ApplicationsMicrofluidics Preparatory Instruments: Access Array System A modular, flexible system that automates amplicon-based library preparation of up to 480 amplicons across48 unique samples per processing run. The resultingbarcoded libraries are ready for targeted DNAsequencing on next-generation sequencing (NGS)platforms from Illumina® and Ion Torrent®. Library preparation for targeted DNAsequencing on NGS systems Juno System An integrated system that automates the preparation ofamplicon-based libraries for targeted next-generationDNA sequencing. Additionally, Juno automatesmicrofluidic workflows for PCR-based gene expression,genotyping, digital PCR, and copy number variantanalysis by processing IFCs prior to analysis onBiomark HD or EP1 platforms. Library preparation for targeted DNAsequencing on NGS systems. End-PointPCR, SNP Genotyping, sampleidentification, Gene Expression, anddigital PCR Analytical Instruments: Biomark HD System Real-time PCR analytical instrument for microfluidics-based analysis of gene expression, single-cell targetedgene expression, microRNA expression, sampleidentification, SNP genotyping, and real-time digitalPCR. SNP Genotyping, sample identification,Digital PCR, and Gene Expression,including Single-Cell Targeted GeneExpression EP1 System End-point PCR analytical instrument for microfluidics-based analysis of SNP genotyping and end-point digitalPCR. SNP Genotyping, sample identification,and Digital PCR Integrated Fluidic Circuits (IFCs): LP IFCs Library Preparation IFCs to support targeted DNAsequencing of 48 or 192 samples on next generationsequencing instruments. Library preparation for targeted next-generation DNA sequencing Juno Genotyping IFC IFC that incorporates preamplification for genotypingof 96 samples and 96 markers on a single run. Genotyping, sample identification Dynamic Array IFCs IFCs based on matrix architecture, allowing users to (i)individually assay up to 24 samples against up to 192assays, (ii) individually assay up to 48 samples againstup to 48 assays, (iii) individually assay up to 96samples against up to 96 assays, or (iv) individuallyassay up to 192 samples against up to 24 assays. Real-time qPCR, End-Point PCR, SNPGenotyping and Gene Expression,including Single-Cell Targeted GeneExpression, sample identification, copynumber variant analysis Digital Array IFCs IFCs based on partitioning architecture allowing usersto (i) individually assay up to 12 samples or panelsacross 765 chambers, or to (ii) individually assay up to48 samples across 770 chambers per IFC. Digital PCR, Copy Number Variation andVariant Detection Flex Six IFC IFC that incorporates six 12 X 12 partitions that can beorganized in any configuration, in up to six separateexperimental runs. Gene Expression and SNP Genotyping 3Product Product Description ApplicationsAssays and Reagents: Delta Gene and SNP Type Assays Custom designed assays targeted to genomic regions ofinterest for genotyping and gene expression. Gene Expression, Single-Cell TargetedGene Expression, SNP Genotyping Access Array Target-Specific Primers andTargeted Sequencing Prep Primers Custom designed assays for NGS library preparationusing Access Array chemistry on the Access Array orJuno systems. Library preparation for targeted next-generation DNA sequencing Targeted DNA Seq Library Assays Custom designed assays for NGS library preparationusing Targeted DNA Sequencing Library Preparationchemistry on the Access Array or Juno systems. Library preparation for targeted next-generation DNA sequencing Single Cell Microfluidics Preparatory Instrument: C1 System Sample preparation system that rapidly and reliablyisolates and processes individual cells for genomicanalysis. Single-Cell Targeted Gene Expression,Single-Cell microRNA Analysis, Single-Cell mRNA Sequencing (Full Length andEnd-Counting), Single-Cell Targeted DNASequencing, Single-Cell Whole ExomeSequencing, and Single-Cell WholeGenome DNA Sequencing, Single-CellEpigenetics, Total RNA sequencing, T-ATAC-seq, REAP-Seq (RNA and Protein) Preparatory Analytical Instruments: Polaris System System and IFC that enables single cell contextualstudies by facilitating active/live cell selection,isolation, imaging, dosing, and cell culturingworkflows. Functional Genomics Using Single-CellmRNA Sequencing C1 IFCs IFCs that capture up to 800 cells between 5-25 micronsin diameter and then automatically process the cells fora variety of genomic analysis using thermal andpneumatic controls at nanoliter scale. Single-Cell Targeted Gene Expression,Single-Cell microRNA Analysis, Single-Cell mRNA Sequencing (Full Length andEnd-Counting), Single-Cell Targeted DNASequencing, Single-Cell Whole ExomeDNA Sequencing, and Single-Cell WholeGenome DNA Sequencing, Total RNAsequencing, T-ATAC-seq, REAP-Seq(RNA and Protein). Additional customerand 3rd-party developed applicationsavailable through Fluidigm Script Hub Polaris IFC IFC that actively selects, captures and cultures up to 48single-cells for up to 24 hours. It integrates mediaexchange, dosing and time course studies followed bycell lysis, reverse transcriptions and library preparationfor single cell mRNA sequencing. Functional Genomics of Single Cells 4TechnologyMulti-Layer Soft LithographyOur IFCs are manufactured using multi-layer soft lithography technology, or MSL technology, to create valves, chambers, channels and other fluidiccomponents on our IFCs that allow nanoliter quantities of fluids to be precisely manipulated within the IFC. We have developed commercial manufacturingprocesses to fabricate valves, channels, vias, and chambers with dimensions in the ten to 100 micron range, at high density and with high yields.Integrated Fluidic CircuitsOur IFCs incorporate several different types of technology that together enable us to use MSL technology to rapidly design and deploy newmicrofluidic applications. The first level of our IFC technology is a library of components that perform basic microfluidic functions, such as pumps, mixers,single-cell capture chambers, separation columns, control logic, and reaction chambers. The second level of our IFC technology comprises the architectureswe have designed to exploit our ability to conduct thousands of reactions on a single IFC. The third level of our IFC technology involves the interaction ofour IFCs with the actual laboratory environment. Our IFCs are built on specially designed input frames that are compatible with most commonly usedlaboratory systems.Instrumentation and SoftwareOur mass cytometry instrumentation technology includes a custom-designed inductively coupled plasma ion source, ion-optical and vacuum systems,and instrument control electronics. With our Helios system, which is an enhanced version of our CyTOF 2 system, individual cells are atomized, ionized, andextracted. A time-of-flight mass analyzer separates atomic ions of different mass-to-charge ratios, providing information on temporal distribution of ions. TheHyperion Imaging System combines mass cytometry technology with imaging capability to enable simultaneous interrogation of up to 37 protein markers inthe spatial context of the tissue microenvironment. Our systems have the ability to utilize up to 135 channels to detect additional parameters to meet futuremarket needs.Our Biomark HD system includes our custom thermal cycler, the FC1 cycler, and a sophisticated fluorescence imaging system. Our EP1 instrument is afluorescence reader designed for end-point imaging, suitable for genotyping and digital PCR applications. Our C1 system combines the hardware elements ofour IFC controllers and FC1 cycler with sophisticated scripting and protocol control software to enable automation of single-cell capture and preparation forsubsequent analysis. Certain capabilities of the C1 system have been used to create our Juno system, which serves as a universal controller and cycler for ourDynamic Array IFCs. Our Polaris system combines the capabilities of all these instruments by incorporating thermal cycling, IFC control, environmentalregulation, and imaging.We have developed instrumentation technology to load samples and reagents onto our IFCs and to control and monitor reactions within our IFCs. Ourline of IFC controllers consists of commercial pneumatic components and both custom and commercial electronics. They apply precise control of multiplepressures to move fluid and control valve states in a microfluidic IFC.We have also developed specialized software to manage and analyze the unusually large amounts of data produced by our systems. We offer FluidigmCytobank, our cloud-based platform of analytical tools, for use with the Helios system. Our bioinformatic toolset, the Singular software, facilitates theanalysis and visualization of single-cell gene expression data. More recently, we extended the scope of the toolset to include DNA analysis tools. We alsodeveloped the C1 Script Builder software to enable customers to take full advantage of the flexibility of C1 IFC architecture by allowing them to programtheir own control scripts for the C1 system.Assays and ReagentsWe manufacture metal-conjugated antibodies for use with our mass cytometry instruments to allow detection of up to approximately 37 protein targetssimultaneously in a single cell. Our metal-conjugated antibodies are manufactured using metal-chelating polymers, which are produced using proprietarypolymerization processes and subsequent post-polymerization modifications.Our Delta Gene and single-nucleotide polymorphism type, or SNP Type, assay products consist of assay design and custom content delivery systems forgene expression and genotyping, respectively. These offerings provide low-cost alternatives to other available chemistries, and allow customers to use IFCsin more flexible ways. PCR assay reagents need to be specific to the gene targets of interest but the process of designing a set of assays may delay theimplementation experiments or require the use of expensive pre-designed assays. We have developed a process to provide customers with validated assays fortheir targets of interest.5Life Science ResearchOur products enable comprehensive interrogation of biological samples across a range of genomic and protein molecular biomarkers.GenomicsOne primary area of focus within life science research is genetic analysis, the study of genes and their functions. The hereditary material or nucleic acidof an organism is often referred to as its genome, the protein-encoding regions of which are commonly known as genes. Analysis of variations in genomes,genes and gene activity in and between organisms can provide valuable insight into their health and functioning. Single-cell genomics is the study of thesequence and expression of genes and their ultimate functions at the individual cell level.There are several forms of genetic analysis in use today, including genotyping, gene expression analysis and DNA sequencing:•Genotyping involves the analysis of DNA variations across individual genomes. There are multiple forms of variants, including single nucleotidepolymorphism, or SNPs, insertion-deletions and copy number variation. A common application of genotyping focuses on analyzing SNPs todetermine whether a SNP or group of SNPs are associated with a particular genetic trait, such as propensity for a disease.•Gene expression analysis involves measuring the levels of particular ribonucleic acid sequences known as messenger RNAs, or mRNAs, whichhave been transcribed from genes. Determining these levels is important because mRNAs are often translated by the cell into proteins, and mayaffect the activity of the cell or the larger organism.•DNA sequencing is a process by which researchers are able to determine the particular order of nucleotide bases that comprise all or a portion of aparticular gene or genome, and typically improves with target enrichment, such as complex sample preparation and tagging processes. Researchersare increasingly using next-generation DNA sequencers to rapidly and cost-effectively sequence portions of genomes, which is important for theidentification of genetic variations that correlate with particular phenotypes.Gene expression and genotyping are studied through a combination of various technology platforms that characterize gene function and geneticvariation. These platforms often rely on PCR amplification to generate exponential copies of a DNA sample to provide sufficient signal to facilitatedetection. Real-time quantitative PCR, or real-time qPCR, is a more advanced form of PCR that makes it possible to quantify the number of copies of DNApresent in a sample.ProteomicsAnother focus within life science research is protein analysis, the study of proteins and their structures and functions. Proteins perform a vast array offunctions within living organisms, including catalyzing metabolic reactions, replicating DNA, signaling response to stimuli and transporting molecules fromone location to another. The proteome varies and is dynamic. Every cell in an individual organism has the same set of genes, but the set of proteins producedin different tissues differ from one another and are dependent on gene expression. Protein analysis is required to profile and understand cellular function aswell as the interaction in tissues and other complex microenvironments.There are several forms of high-throughput protein analysis in use today, including mass spectrometry, traditional flow cytometry,immunohistochemistry and both suspension and imaging mass cytometry.•Mass spectrometry is an analytical chemistry technique that measures the mass-to-charge ratio in molecules using external electric and magneticfields. Mass spectrometry techniques are limited to bulk samples and provide an understanding of global protein dynamics on a tissue or organismlevel, but do not, by themselves, enable researchers to analyze data at a single cell level.•Traditional flow cytometry utilizes a suspension of cells in a stream of fluid and passes them through an electronic detection apparatus to allowsimultaneous multi-parameter analysis of the physical and chemical characteristics of up to thousands of cells per second. Although traditionalflow cytometry technologies are high-throughput with single-cell analysis capabilities, a key limitation is the use of fluorescent dyes to labelantibodies for detection. These fluorescent labels have emission spectra that typically overlap, making it challenging to optimize reagents toanalyze many protein markers at once. In general, the number of protein targets for conventional flow cytometry is less than about 10 withsignificant reagent optimization often involved.6•Immunohistochemistry is a method by which cells in a tissue section are stained with antibodies and then imaged with a conventional orfluorescent microscope. Antibodies selected to bind to proteins of interest can be conjugated with either chromogenic or fluorescent labels,allowing cellular proteins to be visualized in spatial context. Immunohistochemistry is used broadly throughout the life sciences industry, and inclinical research to better understand the characteristics and relationship of cancerous versus normal cells in biopsy tissue. In general, the numberof simultaneously imageable proteins is less than five, with researchers only able to achieve a higher-parameter resolution using serial sections(several adjacent sections of the same tissue) or other highly laborious, more serial staining methods.•Suspension mass cytometry is similar to traditional flow cytometry but is based primarily on antibodies using heavy metal isotope labels ratherthan fluorescent labels for detection of proteins, enabling the significant expansion of the number of parameters analyzed per individual cellversus conventional flow cytometry technologies. With high-throughput, single-cell analysis capabilities and the ability to analyze more proteinmarkers per individual cell, researchers have more granular information, which allows them to identify and characterize even finer subpopulationsof cells.•Imaging mass cytometry is similar to immunohistochemistry, but is also based primarily on antibodies using heavy metal isotope labels ratherthan fluorescent or chromogenic labels for detection of proteins. This method enables a significant expansion of the number of parameterssimultaneously analyzed per tissue section rather than in adjacent sections or via serial staining protocols.CustomersWe sell our instruments to leading academic research institutions, translational research and medicine centers, cancer centers, clinical researchlaboratories, and biopharmaceutical, biotechnology, and plant and animal research companies. No single customer represented more than 10% of our totalrevenue for 2018, 2017, or 2016.Marketing, Sales, Service and SupportWe distribute our systems through our direct sales force and support organizations located in North America, Europe, and Asia-Pacific, and throughdistributors or sales agents in several European, Latin American, Middle Eastern, and Asia-Pacific countries. Our sales and marketing efforts are targeted atlaboratory directors and principal investigators at leading academic, translational research, healthcare consortiums, and biopharmaceutical companies whoneed reliable life science automation solutions to power their disease research with the goal of providing actionable insights.Our sales process often involves numerous interactions and demonstrations with multiple people within an organization. Some potential customersconduct in-depth evaluations of the system, including running experiments on our system and competing systems. In addition, in most countries, sales toacademic or governmental institutions require participation in a tender process involving preparation of extensive documentation and a lengthy reviewprocess. As a result of these factors and the budget cycles of our customers, our sales cycle, the time from initial contact with a customer to our receipt of apurchase order, can often be 12 months or longer.As of December 31, 2018, we had 190 people employed in sales, technical support, and marketing, including 82 sales representatives and applicationsspecialists located in the field.ManufacturingOur manufacturing operations are primarily located in Singapore and Canada. Our facility in Singapore manufactures our IFCs and manages productionof our genomics instruments, which are assembled by our contract manufacturer located within our Singapore facility. All of our IFCs for commercial sale andsome IFCs for our research and development purposes are also fabricated at our Singapore facility. Our mass cytometry instruments for commercial sale, aswell as for internal research and development purposes, are manufactured at our facility in Canada. We also manufacture assays and reagents at our facilitiesin the United States. As part of our on-going efforts related to operational excellence and improving efficiencies, we are consolidating our North Americanproduction activities into our Canadian facility. We rely on a limited number of suppliers for certain components and materials used in our products. Key components in our products that are suppliedby sole or limited source suppliers include a specialized polymer and other specialized materials from which our IFC cores are fabricated, specialized customcamera lenses, fiber light guides, and other components required for the reader of our Biomark system; specialized pneumatic and electronic components forour C1, Juno, Callisto, and Polaris systems; the electron multiplier detector included in, and certain metal isotopes used with, our7Helios system; specially developed lasers used in our Hyperion Imaging System; and certain raw materials for our Delta Gene and SNP Type assays andAccess Array Target-Specific primers. The loss of a single or sole source supplier would require significant time and effort to locate and qualify an alternativesource of supply, if at all, and could adversely impact our business. For additional information, please see the section entitled “Risk factors” in Part I, Item 1Aof this Form 10-K.Research and DevelopmentWe have assembled experienced research and development teams at our South San Francisco, California, Markham, Ontario, Canada, and Singaporelocations with the scientific, engineering, software, bioinformatic, and process talent that we believe is required to grow our business.The largest component of our current research and development effort is in the areas of new products, new applications and new content. We developeda high-throughput C1 IFC (HT IFC) for handling up to 800 medium sized cell types applied to the work-flows of the Fluidigm-installed base instruments. Inthe area of mass cytometry, we developed an initial prototype imaging mass cytometer instrument in 2016, and successfully launched the commercialHyperion Imaging System in October 2017. The imaging mass cytometer system provides spatial resolution of protein expression in complex tissue samplesat the single-cell level, quantitative measurement using metal isotope tags, and analysis of up to 37 proteins. We also developed metal-labeled antibodiescompatible with formalin fixed paraffin embedded tissue samples, to be used with the Hyperion. We also invest significantly in research and developmentefforts to expand our single-cell and production genomics applications. For example, we continue to develop and commercialize various panel sets for cancerresearch for use with our systems. In 2017, we successfully launched the Advanta™ Immuno-Oncology Gene Expression Assay, which is a 170-geneexpression qPCR assay that enables profiling of tumor immunobiology and new biomarker identification.The second component of our research and development effort is to continuously develop new manufacturing processes and test methods to drive downmanufacturing costs, increase manufacturing throughput, widen fabrication process capability, and support new microfluidic devices and designs.Our research and development expenses were $30.0 million, $30.8 million and $38.4 million in 2018, 2017, and 2016 respectively. As of December 31,2018, 103 of our employees were engaged in research and development activities.CompetitionThe life science markets are highly competitive and expected to grow more competitive with the increasing knowledge gained from ongoing researchand development. We believe that the principal competitive factors in our target markets include competition for human resources; cost of capital equipmentand supplies; reputation among customers; innovation in product offerings; flexibility and ease of use; accuracy and reproducibility of results; andcompatibility with existing laboratory processes, tools, and methods.We compete with both established and development stage life science companies that design, manufacture, and market instruments for gene expressionanalysis, genotyping, other nucleic acid detection, protein expression analysis, imaging, and additional applications. In addition, a number of othercompanies and academic groups are in the process of developing novel technologies for life science markets. Many of our competitors enjoy severalcompetitive advantages over us, including significantly greater name recognition; greater financial and human resources; broader product lines and productpackages; larger sales forces and eCommerce channels; larger and more geographically dispersed customer support organization; substantial intellectualproperty portfolios; larger and more established customer bases and relationships; greater resources dedicated to marketing efforts; better established andlarger scale manufacturing capability; and greater resources and longer experience in research and development. For additional information, please see thesection entitled “Risk factors” in Part I, Item 1A of this Form 10-K.To successfully compete with existing products and future technologies, we need to demonstrate to potential customers that the performance of ourtechnologies and products, the solutions we provide our customers, as well as our customer support capabilities, are superior to those of our competitors. Todifferentiate our company from other, larger enterprises, we need to introduce new and innovative offerings regularly and maintain a well-staffed commercialteam “in the field” to successfully communicate the advantages of our products and overcome potential obstacles to acceptance of our products. In addition,ongoing collaborations and partnerships with key opinion leaders are desirable to demonstrate both biological innovation and applications that solvecustomer problems.8Intellectual PropertyPatentsWe have developed a portfolio of issued patents and patent applications directed to commercial products and technologies in development. As ofDecember 31, 2018, we owned or licensed over 550 patents and we had approximately 155 pending patent applications worldwide. Our patents haveexpiration dates ranging up to 2036.License AgreementsWe have entered into licenses for technologies from various companies and academic institutions.Microfluidic Technologies. Our core microfluidics technology originated at the California Institute of Technology, or Caltech, in the laboratory ofProfessor Stephen Quake, who is a co-founder of Fluidigm. We license microfluidics technology from Caltech, Harvard University, and Caliper Life Sciences,Inc. (Caliper), which subsequently became a PerkinElmer company:•We exclusively license from Caltech relevant patent filings relating to developed technologies that enable the production of specialized valvesand pumps capable of controlling fluid flow at nanoliter volumes. The license agreement will terminate as to each country and licensed productupon expiration of the last-to-expire patent covering licensed products in each country. The U.S. issued patents we have licensed from Caltechexpire between 2017 and 2030.•We have entered into a co-exclusive license agreement with Harvard University for the license of relevant patent filings relating to microfluidictechnology. The license agreement will terminate with the last-to-expire of the licensed patents. The U.S. issued patents we have licensed fromHarvard University expire between 2019 and 2027.•In May 2011, we entered into a license agreement with Caliper to license Caliper’s existing patent portfolio in certain fields. The licenseagreement will terminate with the last-to-expire of the licensed patents. As later amended, the license agreement provides for certain royaltypayments until mid-2018 for our existing products at the time of amendment and their future equivalents.Instrumentation and Digital PCR. On June 30, 2011, we settled litigation and entered into a series of patent cross-license and sub-license agreementswith Life Technologies Corporation (now part of Thermo Fisher Scientific) and its subsidiary Applied Biosystems, LLC, referred to as Life. The agreementsinvolve a cross-license concerning our imaging readers and other patent filings and certain of Life’s patent families relating to methods and instruments forconducting nucleic acid amplification, such as with PCR; a sub-license that provides us access to certain of Life’s digital PCR patents; and a sublicense thatprovides Life access to certain of our non-core technology patents licensed from Caltech. In July 2011, pursuant to the terms of the agreements, we paid Life$2.0 million in connection with our exercise of an option to preclude Life from initiating litigation under its patents existing as of June 30, 2011 against ourcustomers for two years and against our company, with respect to our current products and equivalent future products, for four years, subject to certainexceptions. In November 2017, we settled pending litigation with Life and, pursuant to the terms of the settlement, one of the patent license agreements wasamended to provide Life with a fully paid-up license under the patents covered by the agreement, subject to certain field of use restrictions. The licenseagreement will terminate with the last-to-expire of the licensed patents, which is expected to be in 2028.Mass Cytometry. Some of the intellectual property rights covering our mass cytometry products were subject to a license agreement, referred to as theOriginal License Agreement, between Fluidigm Canada Inc., referred to as Fluidigm Canada, and PerkinElmer Health Sciences, Inc., referred to asPerkinElmer. Under the Original License Agreement, Fluidigm Canada received an exclusive, royalty bearing, worldwide license to certain patents owned byPerkinElmer in the field of inductively coupled plasma, or ICP-based mass cytometry, including the analysis of elemental tagged materials in connectiontherewith, referred to as the Patents, and a non-exclusive license for reagents outside the field of ICP-based mass cytometry. On November 4, 2015, weentered into a patent purchase agreement with PerkinElmer pursuant to which we purchased the Patents for a purchase price of $6.5 million and a patentassignment agreement pursuant to which PerkinElmer transferred and assigned to us all rights, title, privileges, and interest in and to the Patents and theOriginal License Agreement. Accordingly, we have no further financial obligations to PerkinElmer under the Original License Agreement. Contemporaneously with the purchase of the Patents, we entered into a license agreement with PerkinElmer pursuant to which we granted PerkinElmer aworldwide, non-exclusive, fully paid-up license to the Patents in fields other than (i) ICP-based mass analysis of atomic elements associated with a biologicalmaterial, including any elements that are unnaturally bound, directly or indirectly, to such biological material (Mass Analysis) and (ii) the development,design,9manufacture, and use of equipment or associated reagents for such Mass Analysis. The license will terminate on the last expiration date of the Patents,currently expected to be in December 2025, unless earlier terminated pursuant to the terms of the license agreement.Any loss, termination, or adverse modification of our licensed intellectual property rights could have a material adverse effect on our business,operating results, and financial condition. For additional information, please see the section entitled “Risk factors” in Part I, Item 1A of this Form 10-K.OtherIn addition to pursuing patents and licenses on key technologies, we have taken steps to protect our intellectual property and proprietary technologyby entering into confidentiality agreements and intellectual property assignment agreements with our employees, consultants, corporate partners, and, whenneeded, our advisors.Government RegulationOur products are currently labeled and sold for research purposes only, and we sell them to academic institutions, life sciences and clinical researchlaboratories that conduct research, and biopharmaceutical and biotechnology companies for non-diagnostic and non-clinical purposes. Our products are notintended or promoted for use in clinical practice in the diagnosis of disease or other conditions, and they are labeled for research use only, not for use indiagnostic procedures. Accordingly, they are not subject to regulation by the U.S. Food and Drug Administration (FDA). Rather, while FDA regulationsrequire that research use only products be labeled, “For Research Use Only. Not for use in diagnostic procedures,” or RUO products, the regulations do notsubject such products to the FDA’s jurisdiction or the broader pre- and post-market controls for medical devices.In November 2013, the FDA issued a final guidance document stating that merely including a labeling statement that the product is for researchpurposes only will not necessarily render the device exempt from the FDA’s clearance, approval, or other regulatory requirements if the totality ofcircumstances surrounding the distribution of the product indicate that the manufacturer knows its product is being used by customers for diagnostic uses orthe manufacturer intends such a use. These circumstances may include, among other things, written or verbal marketing claims regarding a product’sperformance in clinical diagnostic applications and a manufacturer’s provision of technical support for such activities. In the future, certain of our products orrelated applications could become subject to regulation as medical devices by the FDA. If we wish to label and market our products for use in performingclinical diagnostics, thus subjecting them to regulation by the FDA under premarket and postmarket control as medical devices, unless an exemption applies,we would be required to obtain either prior 510(k) clearance or prior pre-market approval from the FDA before commercializing the product. The FDAclassifies medical devices into one of three classes. Devices deemed to pose lower risk to the patient are placed in either class I or II, which, unless anexemption applies, requires the manufacturer to submit a pre-market notification requesting FDA clearance for commercial distribution pursuant toSection 510(k) of the FFDCA. This process, known as 510(k) clearance, requires that the manufacturer demonstrate that the device is substantially equivalentto a previously cleared and legally marketed 510(k) device or a “pre-amendment” class III device for which pre-market approval applications, or PMAs, havenot been required by the FDA. This FDA review process typically takes from four to twelve months, although it can take longer. Most class I devices areexempted from this 510(k) premarket submission requirement. Devices deemed by the FDA to pose the greatest risk, such as life-sustaining, life-supporting,or implantable devices, or those deemed not substantially equivalent to a legally marketed predicate device, are placed in class III. Class III devices typicallyrequire PMA approval. To obtain PMA approval, an applicant must demonstrate the reasonable safety and effectiveness of the device based, in part, on dataobtained in clinical studies. PMA reviews generally last between one and two years, although they can take longer. Both the 510(k) and the PMA processescan be expensive and lengthy and may not result in clearance or approval. If we are required to submit our products for pre-market review by the FDA, wemay be required to delay marketing and commercialization while we obtain premarket clearance or approval from the FDA. There would be no assurance thatwe could ever obtain such clearance or approval.In some cases, our customers may use our RUO products in their own laboratory-developed tests, or LDTs, or in other FDA-regulated products forclinical diagnostic use. The FDA has historically exercised enforcement discretion in not enforcing the medical device regulations against LDTs and LDTmanufacturers. However, on October 3, 2014, the FDA issued two draft guidance documents that set forth the FDA’s proposed risk-based framework forregulating LDTs, which are designed, manufactured, and used within a single laboratory. In January 2017, the FDA announced that it would not issue finalguidance on the oversight of LDTs and LDT manufacturers, but would seek further public discussion on an appropriate oversight approach and giveCongress an opportunity to develop a legislative solution. Any future legislative or administrative rule making or oversight of LDTs and LDT manufacturersif and when finalized, may impact the sales of our10products and how customers use our products, and may require us to change our business model in order to maintain compliance with these laws.We would become subject to additional FDA requirements if our products are determined to be medical devices or if we elect to seek 510(k) clearanceor pre-market approval. We would need to continue to invest significant time and other resources to ensure ongoing compliance with FDA quality systemregulations and other post-market regulatory requirements. For additional information, please see the section entitled “Risk factors” in Part I, Item 1A of thisForm 10-K.International sales of medical devices are subject to foreign government regulations, which vary substantially from country to country. Outside of theEU, regulatory approval needs to be sought on a country-by-country basis in order to market medical devices. Although there is a trend towardsharmonization of quality system, standards and regulations in each country may vary substantially which can affect timelines of introduction.Environmental MattersWe are subject to many federal, state, local, and foreign environmental regulations. To comply with applicable regulations, we have and will continueto incur significant expense and allocate valuable internal resources to manage compliance-related issues. In addition, such regulations could restrict ourability to expand or equip our facilities, or could require us to acquire costly equipment or to incur other significant expenses to comply with the regulations.For example, the Restriction on the Use of Certain Hazardous Substances in Electrical and Electronic Equipment Directive (RoHS) and the Waste Electricaland Electronic Equipment Directive (WEEE), both enacted in the European Union, regulate the use of certain hazardous substances in, and require thecollection, reuse, and recycling of waste from, products we manufacture. Certain of our products sold in these countries are subject to RoHS and WEEErequirements. If we fail to comply with any present and future regulations, we could be subject to future fines, penalties, and restrictions, such as thesuspension of manufacturing of our products or a prohibition on the sale of products we manufacture. For additional information, please see the sectionentitled “Risk factors” in Part I, Item 1A of this Form 10-K.Additionally, our research and development and manufacturing processes involve the controlled use of hazardous materials, including flammables,toxics, corrosives, and biologics. Our research and manufacturing operations produce hazardous biological and chemical waste products. We seek to complywith applicable laws regarding the handling and disposal of such materials. The volume of such materials used or generated at our facilities is small.However, we cannot eliminate the risk of accidental contamination or discharge and any resultant injury from these materials. We do not currently maintainseparate environmental liability coverage and any such contamination or discharge could result in significant cost to us in penalties, damages, andsuspension of our operations.Geographic Area InformationDuring the last three years, a significant portion of our revenue was generated outside of the United States. Total revenue received from customersoutside the United States totaled $64.8 million, or 57% of our total revenue, in 2018, compared to $56.1 million, or 55% of our total revenue, in 2017, and$51.8 million, or 50% of our total revenue, in 2016. The majority of our long-lived assets are located within the United States, in Singapore and in Canada.Please see Note 3 and Note 12 to our audited consolidated financial statements for additional information regarding geographic areas.SeasonalityOur business is not subject to significant seasonality. However, the timing of customer orders and shipments, customer budget and spending cycles, andnew product releases can result in variability in our quarterly revenues.Raw MaterialsCertain raw materials used in our Delta Gene and SNP Type assays and Access Array target-specific primers are available from a limited number ofsources. Additionally, certain metals used in our Maxpar reagents are available from a sole source. Currently, we do not have supply agreements with thesesuppliers. While we generally attempt to keep our inventory at minimal levels, we purchase incremental inventory as circumstances warrant to protect oursupply chain.BacklogWe manufacture products based on forecasts of our customers’ demand and advance non-binding commitments from customers as to future purchases.Our customers generally do not place purchase orders far in advance. A substantial portion11of our products are sold on the basis of standard purchase orders that are cancellable prior to shipment without penalty. Accordingly, backlog at any giventime is not a meaningful indicator of future sales.EmployeesAs of December 31, 2018, we had 535 employees, of which 103 work in research and development, 107 work in general and administrative, 135 workin manufacturing, and 190 work in sales, technical support, and marketing. None of our employees are represented by a labor union nor are they subject to acollective bargaining agreement.Corporate and Available InformationWe were incorporated in California in May 1999 as Mycometrix Corporation, changed our name to Fluidigm Corporation in April 2001, andreincorporated in Delaware in July 2007. Our principal executive offices are located at 7000 Shoreline Court, Suite 100, South San Francisco, California94080. Our telephone number is (650) 266-6000. Our website address is www.fluidigm.com. We make available on our website, free of charge, our AnnualReport on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and any amendments to those reports, as soon as reasonably practicableafter we electronically file such material with, or furnish it to, the Securities and Exchange Commission, or SEC. Our SEC reports can be accessed through theinvestor relations page of our website located at http://investors.fluidigm.com. The SEC also maintains an Internet site at www.sec.gov that contains reports,proxy and information statements, and other information regarding issuers that electronically file with the SEC.The contents of our website are not a part of, and are not incorporated by reference into, this Annual Report on Form 10-K or any other report ordocument we file with the SEC. Any reference to our website is intended to be an inactive textual reference only.12ITEM 1A. RISK FACTORSWe operate in a rapidly changing environment that involves numerous uncertainties and risks. The following risks and uncertainties may have amaterial and adverse effect on our business, financial condition, or results of operations. You should consider these risks and uncertainties carefully,together with all of the other information included or incorporated by reference in this Form 10-K. The risks described below are not the only ones we face.Our business is also subject to the risks that affect many other companies, such as employment relations, general economic conditions, geopolitical eventsand international operations. Further, additional risks not currently known to us or that we currently believe are immaterial may in the future materiallyand adversely affect our business, operations, liquidity and stock price. If any of the risks or uncertainties we face were to occur, the trading price of oursecurities could decline, and you may lose all or part of your investment.Risks Related to Fluidigm’s Business and StrategyOur financial results and revenue growth rates have varied significantly from quarter-to-quarter and year-to-year due to a number of factors, and asignificant variance in our operating results or rates of growth, if any, could lead to substantial volatility in our stock price.Our revenue, results of operations, and revenue growth rates have varied in the past and may continue to vary significantly from quarter-to-quarter oryear-to-year. We may experience substantial variability in our product mix from period-to-period as revenue from sales of our instruments relative to sales ofour consumables may fluctuate or deviate significantly from expectations. For example, our revenue declined year-over-year in 2016 compared to 2015, andin 2017 compared to 2016. In 2018, we returned to revenue growth, but we may not be able to achieve similar revenue growth in future periods. We are alsoincreasingly dependent on our mass cytometry business, which is very capital intensive. Variability in our quarterly or annual results of operations, mix ofproduct revenue, including any decline in our mass cytometry revenue, or variability in rates of revenue growth, if any, may lead to volatility in our stockprice as research analysts and investors respond to these fluctuations. These fluctuations are due to numerous factors that are difficult to forecast, including:fluctuations in demand for our products; changes in customer budget cycles and capital spending; seasonal variations in customer operations; tendenciesamong some customers to defer purchase decisions to the end of the quarter; the large unit value of our systems, particularly our proteomics systems; changesin our pricing and sales policies or the pricing and sales policies of our competitors; our ability to design, manufacture, market, sell, and deliver products toour customers in a timely and cost-effective manner; fluctuations or reductions in revenue from sales of legacy instruments that may have contributedsignificant revenue in prior periods; quality control or yield problems in our manufacturing operations; our ability to timely obtain adequate quantities of thematerials or components used in our products, which in certain cases are purchased through sole and single source suppliers; new product introductions andenhancements by us and our competitors; unanticipated increases in costs or expenses; our complex, variable and, at times, lengthy sales cycle; globaleconomic conditions; and fluctuations in foreign currency exchange rates. Additionally, we have certain customers who have historically placed large ordersin multiple quarters during a calendar year. A significant reduction in orders from one or more of these customers could adversely affect our revenue andoperating results, and if these customers defer or cancel purchases or otherwise alter their purchasing patterns, our financial results and actual results ofoperations could be significantly impacted. Other unknown or unpredictable factors also could harm our results.The foregoing factors, as well as other factors, could materially and adversely affect our quarterly and annual results of operations and rates of revenuegrowth, if any. We have experienced significant revenue growth in the past but we may not achieve similar growth rates in future periods. You should not relyon our operating results for any prior quarterly or annual period as an indication of our future operating performance. If we are unable to achieve adequaterevenue growth, our operating results could suffer and our stock price could decline. In addition, a significant amount of our operating expenses are relativelyfixed due to our manufacturing, research and development, and sales and general administrative efforts. Any failure to adjust spending quickly enough tocompensate for a shortfall relative to our anticipated revenue could magnify the adverse impact of such shortfalls on our results of operations. We expect thatour sales will continue to fluctuate on an annual and quarterly basis and that our financial results for some periods may be below those projected by securitiesanalysts, which could significantly decrease the price of our common stock.We have incurred losses since inception, and we may continue to incur substantial losses for the foreseeable future.We have incurred significant losses in each fiscal year since our inception, including net losses of $59.0 million, $60.5 million, and $76.0 millionduring the years 2018, 2017, and 2016, respectively. As of December 31, 2018, we had an accumulated deficit of $558.9 million. These losses have resultedprincipally from costs incurred in our research and development programs, and from our manufacturing costs and selling, general, and administrativeexpenses. To date, we have funded our operations primarily through equity offerings, the issuance of debt instruments, and from sales of our products.13Until we are able to generate additional revenue to support our level of operating expenses, we will continue to incur operating and net losses andnegative cash flow from operations. We believe that our continued investment in research and development, sales, and marketing is essential to our long-termcompetitive position and future revenue growth and, as a result, we may incur operating losses for the foreseeable future and may never achieve profitability.The life science markets are highly competitive and subject to rapid technological change, and we may not be able to successfully compete.The markets for our products are characterized by rapidly changing technology, evolving industry standards, changes in customer needs, emergingcompetition, new product introductions, and strong price competition. We compete with both established and development stage life science researchcompanies that design, manufacture, and market instruments and consumables for gene expression analysis, single-cell targeted gene expression or proteinexpression analysis, single nucleotide polymorphism genotyping, or SNP genotyping, polymerase chain reaction, or PCR, digital PCR, other nucleic aciddetection, flow cytometry, cell imaging, and additional applications using well established laboratory techniques, as well as newer technologies such as beadencoded arrays, microfluidics, nanotechnology, high-throughput DNA sequencing, microdroplets, and photolithographic arrays. Most of our currentcompetitors have significantly greater name recognition, greater financial and human resources, broader product lines and product packages, larger salesforces, larger existing installed bases, larger intellectual property portfolios, and greater experience and scale in research and development, manufacturing,and marketing than we do. For example, companies such as 10X Genomics, Inc., Affymetrix, Inc. (now part of Thermo Fisher Scientific Inc.), AgenaBioscience, Inc., Agilent Technologies, Inc., Becton, Dickinson and Company, Bio-Rad Laboratories, Inc., Cellular Research, Inc. (now a part of Becton,Dickinson and Company), Danaher Corporation, Illumina, Inc., Life Technologies Corporation (now part of Thermo Fisher Scientific Inc.), LGC Limited,Luminex Corporation, Millipore Corporation, NanoString Technologies, Inc., PerkinElmer, Inc. (through its acquisition of Caliper Life Sciences, Inc.),RainDance Technologies, Inc. (acquisition by Bio-Rad Laboratories, Inc. pending), Roche Diagnostics Corporation, Sony Corporation, Thermo FisherScientific Inc., WaferGen Bio-systems, Inc., Cytek Biosciences, Inc., Akoya Biosciences, Inc., Innova Biosciences Ltd., QIAGEN N.V., 1CellBio, Inc.,Berkeley Lights, Inc., and Mission Bio, Inc. have products that compete in certain segments of the market in which we sell our products. In addition, we haveexperienced increased competition in the single-cell genomics market, including new product releases from 10X Genomics, Inc. and WaferGen Bio-systems,Inc., as well as the acquisition of Cellular Research by Becton Dickinson and Company and an announced exclusive partnership between Illumina, Inc. andBio-Rad Laboratories, Inc. In addition, due to the release of our Hyperion imaging mass cytometry system, we now are exposed to competition fromcompanies offering imaging-based systems, specialized reagents and/or services including Carl Zeiss Inc., Leica Biosystems, Nikon Corporation, OlympusAmerica Inc., Roche Diagnostics Corporation, PerkinElmer, Inc., Agilent Technologies, Inc., IonPath Inc., Zellwerk GmbH, Bruker Corporation, ShimadzuCorporation, NanoString Technologies, Inc., and Neogenomics (Multiomyx).Competitors may be able to respond more quickly and effectively than we can to new or changing opportunities, technologies, standards, or customerrequirements. In light of these advantages, even if our technology is more effective than the product or service offerings of our competitors, current orpotential customers might accept competitive products and services in lieu of purchasing our technology. We anticipate that we will continue to faceincreased competition in the future as existing companies and competitors develop new or improved products and as new companies enter the market withnew technologies. Increased competition is likely to result in pricing pressures, which could reduce our profit margins and increase our sales and marketingexpenses. In addition, mergers, consolidations, or other strategic transactions between two or more of our competitors, or between our competitor and one ofour key customers, could change the competitive landscape and weaken our competitive position, adversely affecting our business.Market opportunities may not develop as quickly as we expect, limiting our ability to successfully sell our products, or our product development andstrategic plans may change and our entry into certain markets may be delayed, if it occurs at all.The application of our technologies to high-throughput genomics, single-cell genomics and, particularly, mass cytometry applications are in manycases emerging market opportunities. We believe these opportunities will take several years to develop or mature and we cannot be certain that these marketopportunities will develop as we expect. The future growth of our markets and the success of our products depend on many factors beyond our control,including recognition and acceptance by the scientific community, and the growth, prevalence, and costs of competing methods of genetic and proteinanalysis. Additionally, our success depends on the ability of our sales organization to successfully sell our products into these new markets. If we are not ableto successfully market and sell our products, or to achieve the revenue or margins we expect, our operating results may be harmed and we may not recover ourproduct development and marketing expenditures. In addition, our product development and strategic plans may change, which could delay or impede ourentry into these markets.14If our products fail to achieve and sustain sufficient market acceptance, our revenue will be adversely affected.Our success depends on our ability to develop and market products that are recognized and accepted as reliable, enabling and cost-effective. Most ofour potential customers already use expensive research systems in their laboratories and may be reluctant to replace those systems. Market acceptance of oursystems will depend on many factors, including our ability to convince potential customers that our systems are an attractive alternative to existingtechnologies. Compared to some competing technologies, our technology is relatively new, and most potential customers have limited knowledge of, orexperience with, our products. Prior to adopting our systems, some potential customers may need to devote time and effort to testing and validating oursystems. Any failure of our systems to meet these customer benchmarks could result in customers choosing to retain their existing systems or to purchasesystems other than ours, and revenue from the sale of legacy instruments that may have contributed significant revenue in prior periods may decrease.In addition, it is important that our systems be perceived as accurate and reliable by the scientific and medical research community as a whole.Historically, a significant part of our sales and marketing efforts has been directed at convincing industry leaders of the advantages of our systems andencouraging such leaders to publish or present the results of their evaluation of our system. If we are unable to continue to induce leading researchers to useour systems, or if such researchers are unable to achieve and publish or present significant experimental results using our systems, acceptance and adoption ofour systems will be slowed and our ability to increase our revenue would be adversely affected.We may experience development or manufacturing problems or delays that could limit the potential growth of our revenue or increase our losses.We may encounter unforeseen situations in the manufacturing and assembly of our products that would result in delays or shortfalls in our production.For example, our production processes and assembly methods may have to change to accommodate any significant future expansion of our manufacturingcapacity, which may increase our manufacturing costs, delay production of our products, reduce our product margin, and adversely impact our business.Conversely, if demand for our products shifts such that a manufacturing facility is operated below its capacity for an extended period, we may adjust ourmanufacturing operations to reduce fixed costs, which could lead to uncertainty and delays in manufacturing times and quality during any transition period.Additionally, all of our integrated fluidic circuits (IFCs) for commercial sale are manufactured at our facility in Singapore. Production of the elastomericblock that is at the core of our IFCs is a complex process requiring advanced clean rooms, sophisticated equipment, and strict adherence to procedures. Anycontamination of the clean room, equipment malfunction, or failure to strictly follow procedures can significantly reduce our yield in one or more batches.We have in the past experienced variations in yields due to such factors. A drop in yield can increase our cost to manufacture our IFCs or, in more severecases, require us to halt the manufacture of our IFCs until the problem is resolved. Identifying and resolving the cause of a drop in yield can requiresubstantial time and resources.Furthermore, developing an IFC for a new application may require developing a specific production process for that type of IFC. While all of our IFCsare produced using the same basic processes, significant variations may be required to ensure adequate yield of any particular type of IFC. Developing such aprocess can be very time consuming, and any unexpected difficulty in doing so can delay the introduction of a product.If our manufacturing activities are adversely impacted, or if we are otherwise unable to keep up with demand for our products by successfullymanufacturing, assembling, testing, and shipping our products in a timely manner, our revenue could be impaired, market acceptance for our products couldbe adversely affected and our customers might instead purchase our competitors’ products.If our research and product development efforts do not result in commercially viable products within anticipated timelines, if at all, our business andresults of operations will be adversely affected.Our business is dependent on the improvement of our existing products, our development of new products to serve existing markets, and ourdevelopment of new products to create new markets and applications that were previously not practical with existing systems. We intend to devotesignificant personnel and financial resources to research and development activities designed to advance the capabilities of our technology. We havedeveloped design rules for the implementation of our technology that are frequently revised to reflect new insights we have gained about the technology. Inaddition, we have discovered that biological or chemical reactions sometimes behave differently when implemented on our systems rather than in a standardlaboratory environment. Furthermore, many such reactions take place within the confines of single cells, which have also demonstrated unexpected behaviorwhen grown and manipulated within microfluidic environments. As a result, research and development efforts may be required to transfer certain reactionsand cell handling techniques to our systems. In the past,15product development projects have been significantly delayed when we encountered unanticipated difficulties in implementing a process on our systems. Wemay have similar delays in the future, and we may not obtain any benefits from our research and development activities. Any delay or failure by us to developand release new products or product enhancements would have a substantial adverse effect on our business and results of operations.Our products could have defects or errors, which may give rise to claims against us, adversely affect market adoption of our systems, and adverselyaffect our business, financial condition, and results of operations.Our systems utilize novel and complex technology and such systems may develop or contain undetected defects or errors. We cannot assure you thatmaterial performance problems, defects, or errors will not arise, and as we increase the density and integration of our systems, these risks may increase. Wegenerally provide warranties that our systems will meet performance expectations and will be free from defects. The costs incurred in correcting any defects orerrors may be substantial and could adversely affect our operating margins. For example, we have experienced a performance issue with respect to certainIFCs used in our C1 systems due to the presence of more than one cell in an IFC chamber. Although we have redesigned such C1 IFCs, we may experienceadditional unexpected product defects or errors that could affect our ability to adequately address these performance issues.In manufacturing our products, including our systems, IFCs, and assays, we depend upon third parties for the supply of various components, many ofwhich require a significant degree of technical expertise to produce. In addition, we purchase certain products from third-party suppliers for resale. If oursuppliers fail to produce components to specification or provide defective products to us for resale and our quality control tests and procedures fail to detectsuch errors or defects, or if we or our suppliers use defective materials or workmanship in the manufacturing process, the reliability and performance of ourproducts will be compromised.If our products contain defects, we may experience:•a failure to achieve market acceptance or expansion of our product sales;•loss of customer orders and delay in order fulfillment;•damage to our brand reputation;•increased cost of our warranty program due to product repair or replacement;•product recalls or replacements;•inability to attract new customers;•diversion of resources from our manufacturing and research and development departments into our service department; and•legal claims against us, including product liability claims, which could be costly and time consuming to defend and result in substantial damages.In addition, certain of our products are marketed for use with products sold by third parties. For example, certain of our systems are marketed ascompatible with major next-generation DNA sequencing instruments. If such third-party products are not produced to specification, are produced inaccordance with modified specifications, or are defective, they may not be compatible with our products. In such case, the reliability and performance of ourproducts may be compromised.The occurrence of any one or more of the foregoing could negatively affect our business, financial condition, and results of operations.Our business depends on research and development spending levels of our customers, a reduction in which could limit our ability to sell our productsand adversely affect our business.We expect that our revenue in the foreseeable future will continue to be derived primarily from sales of our systems, IFCs, assays, and reagents toacademic research institutions, translational research and medicine centers, cancer centers, clinical research laboratories biopharmaceutical, biotechnology,and agricultural biotechnology (Ag-Bio) companies, and contract research organizations worldwide. Our success will depend upon their demand for and useof our products. Accordingly, the spending policies of these customers could have a significant effect on the demand for our technology. These policies maybe based on a wide variety of factors, including concerns regarding any future federal government budget sequestrations, the availability of resources to makepurchases, the spending priorities among various types of equipment, policies regarding16spending during recessionary periods, and changes in the political climate. In addition, academic, governmental, and other research institutions that fundresearch and development activities may be subject to stringent budgetary constraints that could result in spending reductions, reduced allocations, orbudget cutbacks, which could jeopardize the ability of these customers to purchase our products. Our operating results may fluctuate substantially due toreductions and delays in research and development expenditures by these customers. For example, reductions in capital and operating expenditures by thesecustomers may result in lower than expected sales of our systems, IFCs, assays, and reagents. These reductions and delays may result from factors that are notwithin our control, such as:•changes in economic conditions;•natural disasters;•changes in government programs that provide funding to research institutions and companies;•changes in the regulatory environment affecting life science and Ag-Bio companies engaged in research and commercial activities;•differences in budget cycles across various geographies and industries;•market-driven pressures on companies to consolidate operations and reduce costs;•mergers and acquisitions in the life science and Ag-Bio industries; and•other factors affecting research and development spending.Any decrease in our customers’ budgets or expenditures, or in the size, scope, or frequency of capital or operating expenditures, could materially andadversely affect our operations or financial condition.If one or more of our manufacturing facilities become unavailable or inoperable, we will be unable to continue manufacturing our instruments, IFCs,assays and/or reagents and, as a result, our business will be harmed until we are able to secure a new facility.We manufacture our genomics analytical and preparatory instruments and IFCs for commercial sale at our facility in Singapore and our mass cytometryinstruments for commercial sale at our facility in Canada. Our assays and reagents for commercial sale have been manufactured at our headquarters in theUnited States, however, we are consolidating our North American production activities into our Canada facility as part of our on-going efforts related tooperational excellence and improving efficiencies. No other manufacturing facilities are currently available to us, particularly facilities of the size and scopeof our Singapore and Canada operations. Our facilities and the equipment we use to manufacture our instruments, IFCs, assays, and reagents would be costlyto replace and could require substantial lead times to repair or replace. Our facilities may be harmed or rendered inoperable by natural or man-made disasters,which may render it difficult or impossible for us to manufacture our products for some period of time. If any of our facilities become unavailable to us, wecannot provide assurances that we will be able to secure a new manufacturing facility on acceptable terms, if at all. The inability to manufacture our products,combined with our limited inventory of manufactured supplies, may result in the loss of customers or harm our reputation, and we may be unable toreestablish relationships with those customers in the future. Although we possess insurance for damage to our property and the disruption of our business, thisinsurance may not be sufficient to cover all of our potential losses and may not continue to be available to us on acceptable terms, or at all. If ourmanufacturing capabilities are impaired, we may not be able to manufacture and ship our products in a timely manner, which would adversely impact ourbusiness.We generate a substantial portion of our revenue internationally and our international business exposes us to business, regulatory, political,operational, financial, and economic risks associated with doing business outside of the United States.During the years 2018, 2017, and 2016, approximately 57%, 55%, and 49% respectively, of our product and service revenue was generated from salesto customers located outside of the United States. We believe that a significant percentage of our future revenue will continue to come from internationalsources as we expand our international operations and develop opportunities in other countries. Engaging in international business inherently involves anumber of difficulties and risks, including:•required compliance with existing and changing foreign regulatory requirements and laws that are or may be applicable to our business in thefuture, such as the European Union’s General Data Protection Regulation and other17data privacy requirements, labor and employment regulations, anticompetition regulations, the U.K. Bribery Act of 2010 and other anticorruptionlaws, and the RoHS and WEEE directives, which regulate the use of certain hazardous substances in, and require the collection, reuse, andrecycling of waste from, products we manufacture;•required compliance with U.S. laws such as the Foreign Corrupt Practices Act, and other U.S. federal laws and regulations established by the officeof Foreign Asset Control;•export requirements and import or trade restrictions;•laws and business practices favoring local companies;•longer payment cycles and difficulties in enforcing agreements and collecting receivables through certain foreign legal systems•changes in social, economic, and political conditions or in laws, regulations and policies governing foreign trade, manufacturing, development,and investment both domestically as well as in the other countries and jurisdictions in which we operate and into which we sell our products,including as a result of the 2016 advisory referendum approving the separation of the United Kingdom from the European Union (Brexit);•potentially adverse tax consequences, tariffs, customs charges, bureaucratic requirements, and other trade barriers;•difficulties and costs of staffing and managing foreign operations; and•difficulties protecting or procuring intellectual property rights.If one or more of these risks occurs, it could require us to dedicate significant resources to remedy, and if we are unsuccessful in finding a solution, ourfinancial results will suffer.We are subject to fluctuations in the exchange rate of the U.S. Dollar and foreign currencies.A majority of our product sales are currently denominated in U.S. dollars and fluctuations in the value of the U.S. dollar relative to foreign currenciescould decrease demand for our products and adversely impact our financial performance. For example, if the value of the U.S. dollar increases relative toforeign currencies, our products could become more costly to the international consumer and therefore less competitive in international markets, or if thevalue of the U.S. dollar decreases relative to the Singapore dollar or the Canadian dollar, it would become more costly in U.S. dollars for us to manufactureour products in Singapore and/or in Canada. Additionally, our expenses are generally denominated in the currencies of the countries in which our operationsare located, which is primarily in the United States, with a portion of expenses incurred in Singapore and Canada where a significant portion of ourmanufacturing operations are located. Our results of operations and cash flows are, therefore, subject to fluctuations due to changes in foreign currencyexchange rates. The volatility of exchange rates depends on many factors that we cannot forecast with reliable accuracy. We have experienced and willcontinue to experience fluctuations in our net income or loss as a result of transaction gains or losses related to revaluing certain current asset and currentliability balances that are denominated in currencies other than the functional currency of the entities in which they are recorded. Fluctuations in currencyexchange rates could have an adverse impact on our financial results in the future.Any disruption or delay in the shipping or off-loading of our products, whether domestically or internationally, may have an adverse effect on ourfinancial condition and results of operations.We rely on shipping providers to deliver products to our customers globally. Labor, tariff, or World Trade Organization-related disputes, piracy,physical damage to shipping facilities or equipment caused by severe weather or terrorist incidents, congestion at shipping facilities, inadequate equipmentto load, dock, and offload our products, energy-related tie-ups, or other factors could disrupt or delay shipping or off-loading of our products domesticallyand internationally. Such disruptions or delays may have an adverse effect on our financial condition and results of operations.18We are dependent on single and sole source suppliers for some of the components and materials used in our products, and the loss of any of thesesuppliers could harm our business.We rely on single and sole source suppliers for certain components and materials used in our products. Additionally, several of our instruments areassembled at the facilities of contract manufacturers in Singapore. We do not have long term contracts with our suppliers of these components and materialsor our assembly service providers. The loss of a single or sole source supplier of any of the following components and/or materials would require significanttime and effort to locate and qualify an alternative source of supply, if at all:•The IFCs used in our microfluidic systems are fabricated using a specialized polymer, and other specialized materials, that are available from alimited number of sources. In the past, we have encountered quality issues that have reduced our manufacturing yield or required the use ofadditional manufacturing processes.•The electron multiplier detector included in the Hyperion/Helios systems and certain metal isotopes used with the Hyperion/Helios systems arepurchased from sole source suppliers.•The raw materials for our Delta Gene and SNP Type assays and Access Array target-specific primers are available from a limited number of sources.Our reliance on single and sole source suppliers and assembly service providers also subjects us to other risks that could harm our business, includingthe following:•we may be subject to increased component or assembly costs and•we may not be able to obtain adequate supply or services in a timely manner or on commercially reasonable terms.We have in the past experienced quality control and supply problems with some of our suppliers, such as manufacturing errors, and may againexperience problems in the future. We may not be able to quickly establish additional or replacement suppliers, particularly for our single sourcecomponents, or assembly service providers. Any interruption or delay in the supply of components or materials or assembly of our instruments, or ourinability to obtain components, materials, or assembly services from alternate sources at acceptable prices in a timely manner, could impair our ability tomeet the demand of our customers and cause them to cancel orders or switch to competitive products.Our future success is dependent upon our ability to expand our customer base and introduce new applications.Our customer base is primarily composed of academic research institutions, translational research and medicine centers, cancer centers, clinical researchlaboratories, biopharmaceutical, biotechnology, and Ag-Bio companies, and contract research organizations that perform analyses for research andcommercial purposes. Our success will depend, in part, upon our ability to increase our market share among these customers, attract additional customersoutside of these markets, and market new applications to existing and new customers as we develop such applications. Attracting new customers andintroducing new applications require substantial time and expense. For example, it may be difficult to identify, engage, and market to customers who areunfamiliar with the current applications of our systems. Any failure to expand our existing customer base or launch new applications would adversely affectour ability to increase our revenue.We may not be able to develop new products or enhance the capabilities of our existing systems to keep pace with rapidly changing technology andcustomer requirements, which could have a material adverse effect on our business, revenue, financial condition, and operating results.Our success depends on our ability to develop new products and applications for our technology in existing and new markets, while improving theperformance and cost-effectiveness of our systems. New technologies, techniques, or products could emerge that might offer better combinations of price andperformance than our current or future product lines and systems. Existing markets for our products, including high-throughput genomics, single-cellgenomics and mass cytometry, as well as potential markets for our products such as high-throughput DNA sequencing and molecular applications, arecharacterized by rapid technological change and innovation. It is critical to our success for us to anticipate changes in technology and customer requirementsand to successfully introduce new, enhanced, and competitive technology to meet our customers’ and prospective customers’ needs on a timely and cost-effective basis. Developing and implementing new technologies will require us to incur substantial development costs and we may not have adequateresources available to be able to successfully introduce new applications of, or enhancements to, our systems. We cannot guarantee that we will be able tomaintain technological advantages over emerging technologies in the future. While we typically plan improvements to our systems, we may not be able tosuccessfully implement these improvements. If we fail to keep pace with emerging technologies, demand for our systems will not grow and may decline, andour business, revenue, financial condition, and19operating results could suffer materially. In addition, if we introduce enhanced systems but fail to manage product transitions effectively, customers maydelay or forgo purchases of our systems and our operating results may be adversely affected by product obsolescence and excess inventory. Even if wesuccessfully implement some or all of these planned improvements, we cannot guarantee that our current and potential customers will find our enhancedsystems to be an attractive alternative to existing technologies, including our current products.Our business operations depend upon the continuing efforts of our management team and other skilled and experienced personnel, and if we are unableto retain them or to recruit and train new key executives, scientists, and technical support personnel, we may be unable to achieve our goals.Our success depends largely on the skills, experience, and performance of key members of our management team and key scientific and technicalsupport personnel. The loss of the services of any key member of our management team or our scientific or technical support staff might significantly delay orprevent the development of our products or achievement of other business objectives by diverting management’s attention to transition matters andidentification of suitable replacements, if any, and could have a material adverse effect on our business. Our research and product development efforts couldalso be delayed or curtailed if we are unable to attract, train, and retain highly skilled employees, particularly, senior scientists and engineers. We do notmaintain fixed term employment contracts or significant key man life insurance with any of our employees.Additionally, to expand our research and product development efforts, we need to retain and recruit key scientists skilled in areas such as molecular andcellular biology, assay development, and manufacturing. We also need highly trained technical support personnel with the necessary scientific backgroundand ability to understand our systems at a technical level to effectively support potential new customers and the expanding needs of current customers.Competition for these people is intense and we may face challenges in retaining and recruiting such individuals if, for example, our stock price declines,reducing the retention value of equity awards, or our business or technology is no longer perceived as leading in our field. Because of the complex andtechnical nature of our systems and the dynamic market in which we compete, any failure to attract and retain a sufficient number of qualified employeescould materially harm our ability to develop and commercialize our technology.Our business growth strategy involves the potential for significant acquisitions, and our operating results and prospects could be harmed if we areunable to integrate future acquisitions successfully.We may acquire other businesses to improve our product offerings or expand into new markets. Our future acquisition strategy will depend on ourability to identify, negotiate, complete, and integrate acquisitions and, if necessary, to obtain satisfactory debt or equity financing to fund those acquisitions.Mergers and acquisitions are inherently risky, and any transaction we complete may not be successful. Any merger or acquisition we may pursue wouldinvolve numerous risks, including but not limited to the following:•difficulties in integrating and managing the operations, technologies, and products of the companies we acquire;•diversion of our management’s attention from normal daily operation of our business;•our inability to maintain the key business relationships and the reputations of the businesses we acquire;•our inability to retain key personnel of the acquired company;•uncertainty of entry into markets in which we have limited or no prior experience and in which competitors have stronger market positions;•our dependence on unfamiliar affiliates and customers of the companies we acquire;•insufficient revenue to offset our increased expenses associated with acquisitions;•our responsibility for the liabilities of the businesses we acquire, including those which we may not anticipate; and•our inability to maintain internal standards, controls, procedures, and policies.We may be unable to secure the equity or debt funding necessary to finance future acquisitions on terms that are acceptable to us. If we financeacquisitions by issuing equity or convertible debt securities, our existing stockholders will likely experience dilution, and if we finance future acquisitionswith debt funding, we will incur interest expense and may have to comply with financial covenants and secure that debt obligation with our assets.20Security breaches, loss of data, cyberattacks, and other information technology failures could disrupt our operations, damage our reputation, andadversely affect our business, operations, and financial results.We are dependent upon our data and information technology systems for the effective operation of our business and for the secure maintenance andstorage of confidential data relating to our business and third-party businesses. Our information technology systems may be damaged, disrupted or shut downdue to attacks by experienced programmers or hackers who may be able to penetrate our security controls and deploy computer viruses, cyberattacks,phishing schemes, or other malicious software programs, or due to employee error or malfeasance, power outages, hardware failures, telecommunication orutility failures, catastrophes or other unforeseen events, and our system redundancy and other disaster recovery planning may be ineffective or inadequate inpreventing or responding to any of these circumstances. Any such compromise of our information technology systems could result in the unauthorizedpublication of our confidential business or proprietary information and unauthorized release of customer, supplier or employee data, any of which couldexpose us to a risk of legal claims or proceedings, liability under privacy or other laws, disruption of our operations and damage to our reputation, whichcould divert our management’s attention from the operation of our business and materially and adversely affect our business, revenues and competitiveposition. In addition, our liability insurance may not be sufficient in type or amount to cover us against claims related to security breaches, cyberattacks andother related breaches. The cost and operational consequences of implementing further data protection measures, either as a response to specific breaches oras a result of evolving risks, could be significant. In addition, our inability to use or access our information systems at critical points in time could adverselyaffect the timely and efficient operation of our business. Any delayed sales, significant costs or lost customers resulting from these technology failures couldadversely affect our business, operations, and financial results.We have implemented security controls to protect our information technology infrastructure but, despite our efforts, we are not fully insulated fromtechnology disruptions that could adversely impact us. For example, in early March 2019, we experienced a ransomware attack that infiltrated and encryptedcertain of our information technology systems, including systems containing critical business data. Immediately following the attack, actions were taken torecover the compromised systems and we believe we were able to restore their operation without significant loss of business data. Based on the nature of theattack and its impact on our systems, we do not believe confidential data was lost or disclosed, but we are continuing to monitor the situation. If confidentialdata is later determined to have been released in the course of this event, it is possible that we could be the subject of actions by governmental authorities orclaims from persons alleging they suffered damages from such a release. As of the date of this filing, we estimate the costs associated with the intrusion to beapproximately $1.5 million; and are seeking to recover these costs under an applicable insurance policy. Although we believe we have now contained thedisruption, we anticipate additional work and expense in the future as we continue to respond to the attack and further enhance our security processes andinitiatives.In addition to risks affecting our own systems, we could also be negatively impacted by a data breach or cyber incident happening to a third party’snetwork and affecting us. Third parties with which we conduct business have access to certain portions of our sensitive data, including information pertainingto our customers and employees. In the event that these third parties do not adequately safeguard our data, security breaches could result and negativelyimpact our business, operations, and financial results.Our efficiency and cost-savings initiatives could be disruptive to our operations and adversely affect our results of operations and financial condition,and we may not realize some or all of the anticipated benefits of these initiatives in the time frame anticipated or at all.Since 2017, we have been implementing efficiency and cost-savings initiatives intended to stabilize our business operations and return to growth.These efficiency initiatives have included targeted workforce reductions, optimizing our facilities, and reducing excess space. Further actions such as thesemay be required on an ongoing basis to optimize our organization. For example, we may need to decrease or defer capital expenditures and developmentactivities or implement further operating expense reduction measures. The implementation of these efficiency and cost-savings initiatives could impair ourability to invest in developing, marketing and selling new and existing products, be disruptive to our operations, make it difficult to attract or retainemployees, result in higher than anticipated charges, divert the attention of management, result in a loss of accumulated knowledge, impact our customer andsupplier relationships, and otherwise adversely affect our results of operations and financial condition. In addition, our ability to complete our efficiency andcost-savings initiatives and achieve the anticipated benefits within the expected time frame is subject to estimates and assumptions and may vary materiallyfrom our expectations, including as a result of factors that are beyond our control. Furthermore, our efforts to grow our business and become profitable maynot be successful.21To use our products, our Biomark, EP1, and Helios/CyTOF 2 systems in particular, customers typically need to purchase specialized reagents. Anyinterruption in the availability of these reagents for use in our products could limit our ability to market our products.Our products, our Biomark, EP1, and Helios systems in particular, must be used in conjunction with one or more reagents designed to produce orfacilitate the particular biological or chemical reaction desired by the user. Many of these reagents are highly specialized and available to the user only froma single supplier or a limited number of suppliers. Although we sell reagents for use with certain of our products, our customers may purchase these reagentsdirectly from third-party suppliers, and we have no control over the supply of those materials. In addition, our products are designed to work with thesereagents as they are currently formulated. We have no control over the formulation of reagents sold by third-party suppliers, and the performance of ourproducts might be adversely affected if the formulation of these reagents is changed. If one or more of these reagents were to become unavailable or werereformulated, our ability to market and sell our products could be materially and adversely affected.In addition, the use of a reagent for a particular process may be covered by one or more patents relating to the reagent itself, the use of the reagent for theparticular process, the performance of that process, or the equipment required to perform the process. Typically, reagent suppliers, who are either the patentholders or their authorized licensees, sell the reagents along with a license or covenant not to sue with respect to such patents. The license accompanying thesale of a reagent often purports to restrict the purposes for which the reagent may be used. If a patent holder or authorized licensee were to assert against us orour customers that the license or covenant relating to a reagent precluded its use with our systems, our ability to sell and market our products could bematerially and adversely affected. For example, our Biomark system involves real-time quantitative polymerase chain reaction (qPCR) technology. Leadingsuppliers of reagents for real-time qPCR reactions include Life Technologies Corporation (now part of Thermo Fisher Scientific) and Roche DiagnosticsCorporation, who are our direct competitors, and their licensees. These real-time qPCR reagents are typically sold pursuant to limited licenses or covenantsnot to sue with respect to patents held by these companies. We do not have any contractual supply agreements for these real-time qPCR reagents, and wecannot assure you that these reagents will continue to be available to our customers for use with our systems, or that these patent holders will not seek toenforce their patents against us, our customers, or suppliers.If we seek to be regulated as a medical device manufacturer by the U.S. Food and Drug Administration and foreign regulatory authorities, and seekapproval and/or clearance for our products, the regulatory approval process would take significant time and expense and could fail to result in FDAclearance or approval for the intended uses we believe are commercially attractive. If our products were successfully approved and/or cleared, wewould be subject to ongoing and extensive regulatory requirements, which would increase our costs and divert resources away from other projects. Ifwe obtained FDA clearance or approval and we failed to comply with these requirements, our business and financial condition could be adverselyimpacted.Our products are currently labeled, promoted and sold to academic research institutions, translational research and medicine centers, cancer centers,clinical research laboratories, contract research organizations, and biopharmaceutical, biotechnology, and Ag-Bio companies “for research use only” (RUO),and are not designed, or intended to be used, for clinical diagnostic tests or as medical devices as currently marketed. Before we can begin to label and marketour products for use as, or in the performance of, clinical diagnostics in the United States, thereby subjecting them to FDA regulation as medical devices, wewould be required to obtain premarket 510(k) clearance or premarket approval from the FDA, unless an exception applies.We may in the future register with the FDA as a medical device manufacturer and list some of our products with the FDA pursuant to an FDA Class Ilisting for general purpose laboratory equipment. While this regulatory classification is exempt from certain FDA requirements, such as the need to submit apremarket notification commonly known as a 510(k), and some of the requirements of the FDA’s Quality System Regulations, or QSRs, we would be subjectto ongoing FDA “general controls,” which include compliance with FDA regulations for labeling, inspections by the FDA, complaint evaluation, correctionsand removals reporting, promotional restrictions, reporting adverse events or malfunctions for our products, and general prohibitions against misbrandingand adulteration.In addition, we may in the future submit 510(k) premarket notifications to the FDA to obtain FDA clearance of certain of our products on a selectedbasis. It is possible, in the event we elect to submit 510(k) applications for certain of our products, that the FDA would take the position that a moreburdensome premarket application, such as a premarket approval application or a de novo application is required for some of our products. If suchapplications were required, greater time and investment would be required to obtain FDA approval. Even if the FDA agreed that a 510(k) was appropriate,FDA clearance can be expensive and time consuming. It generally takes a significant amount of time to prepare a 510(k), including conducting appropriatetesting on our products, and several months to years for the FDA to review a submission. Notwithstanding the22effort and expense, FDA clearance or approval could be denied for some or all of our products. Even if we were to seek and obtain regulatory approval orclearance, it may not be for the intended uses we believe are important or commercially attractive.If we sought and received regulatory clearance or approval for certain of our products, we would be subject to ongoing FDA obligations and continuedregulatory oversight and review, including the general controls listed above and the FDA’s QSRs for our development and manufacturing operations. Inaddition, we would be required to obtain a new 510(k) clearance before we could introduce subsequent modifications or improvements to such products. Wecould also be subject to additional FDA post-marketing obligations for such products, any or all of which would increase our costs and divert resources awayfrom other projects. If we sought and received regulatory clearance or approval and are not able to maintain regulatory compliance with applicable laws, wecould be prohibited from marketing our products for use as, or in the performance of, clinical diagnostics and/or could be subject to enforcement actions,including warning letters and adverse publicity, fines, injunctions, and civil penalties; recall or seizure of products; operating restrictions; and criminalprosecution.In addition, we could decide to seek similar regulatory clearance or approval for certain of our products in countries outside of the United States. Salesof such products outside the United States will likely be subject to foreign regulatory requirements, which can vary greatly from country to country. As aresult, the time required to obtain clearances or approvals outside the United States may differ from that required to obtain FDA clearance or approval and wemay not be able to obtain foreign regulatory approvals on a timely basis or at all. Clearance or approval by the FDA does not ensure approval by regulatoryauthorities in other countries, and approval by one foreign regulatory authority does not ensure approval by regulatory authorities in other countries or bythe FDA. In Europe, we would need to comply with the Medical Device Directive 93/42 EEC and/or the In Vitro Diagnostics Directive 98/79/EC, which arerequired to market medical devices in the European Union. These directives have been replaced by Medical Device Regulation 2017/745 and In VitroDiagnostic Regulation 2017/746, with official entry into force in May 26, 2017 and date of applications of May 26, 2020 and May 26, 2022 respectively.This will increase the difficulty of regulatory approvals in Europe in the future. In addition, the FDA regulates exports of medical devices. Failure to complywith these regulatory requirements or obtain and maintain required approvals, clearances and certifications could impair our ability to commercialize ourproducts for diagnostic use outside of the United States.Our products could become subject to regulation as medical devices by the FDA or other regulatory agencies before we have obtained regulatoryclearance or approval to market our products for diagnostic purposes, which would adversely impact our ability to market and sell our products andharm our business.As products that are currently labeled, promoted and intended “for research use only” (RUO), our products are not currently subject to regulation asmedical devices by the FDA or comparable agencies of other countries. However, the FDA or comparable agencies of other countries could disagree with ourconclusion that our products are currently intended for research use only or deem our current sales, marketing and promotional efforts as being inconsistentwith research use only products. For example, our customers may independently elect to use our research use only labeled products in their own laboratorydeveloped tests (LDTs) for clinical diagnostic use. The FDA has historically exercised enforcement discretion in not enforcing the medical device regulationsagainst laboratories offering LDTs. However, on October 3, 2014, the FDA issued two draft guidance documents that set forth the FDA’s proposed risk-basedframework for regulating LDTs, which are designed, manufactured, and used within a single laboratory. The draft guidance documents provide theanticipated details through which the FDA would propose to establish an LDT oversight framework, including premarket review for higher-risk LDTs, such asthose that have the same intended use as FDA-approved or cleared companion diagnostic tests currently on the market. In January 2017, the FDA announcedthat it would not issue final guidance on the oversight of LDTs and LDT manufacturers, but would seek further public discussion on an appropriate oversightapproach, and give Congress an opportunity to develop a legislative solution. Any future legislative or administrative rule making or oversight of LDTs andLDT manufacturers, if and when finalized, may impact the sales of our products and how customers use our products, and may require us to change ourbusiness model in order to maintain compliance with these laws. We cannot predict how these various efforts will be resolved, how Congress or the FDA willregulate LDTs in the future, or how that regulatory system will impact our business.Additionally, on November 25, 2013, the FDA issued Final Guidance “Distribution of In Vitro Diagnostic Products Labeled for Research Use Only.”The guidance emphasizes that the FDA will review the totality of the circumstances when it comes to evaluating whether equipment and testing componentsare properly labeled as RUO. The final guidance states that merely including a labeling statement that the product is for research purposes only will notnecessarily render the device exempt from the FDA’s clearance, approval, and other regulatory requirements if the circumstances surrounding the distribution,marketing and promotional practices indicate that the manufacturer knows its products are, or intends for its products to be, used for clinical diagnosticpurposes. These circumstances may include written or verbal sales and marketing claims or links to articles regarding a product’s performance in clinicalapplications and a manufacturer’s provision of technical support for clinical applications.23If the FDA modifies its approach to our products labeled and intended as RUO, or otherwise determines our products or related applications should besubject to additional regulation as in vitro diagnostic devices based upon customers’ use of our products for clinical diagnostic or therapeutic purposes,before we have obtained regulatory clearance or approval to market our products for diagnostic purposes, our ability to market and sell our products could beimpeded and our business, prospects, results of operations and financial condition may be adversely affected. In addition, if the FDA determines that ourproducts labeled as RUO were intended, based on a review of the totality of circumstances, for use in clinical investigation or diagnosis, those products couldbe considered misbranded or adulterated under the Federal Food, Drug, and Cosmetic Act and subject to recall and/or other enforcement action.Compliance or the failure to comply with current and future regulations affecting our products and business operations worldwide, such asenvironmental regulations enacted in the European Union, could cause us significant expense and adversely impact our business.We are subject to many federal, state, local, and foreign regulations relating to various aspects of our business operations. Governmental entities at alllevels are continuously enacting new regulations, and it is difficult to identify all applicable regulations and anticipate how such regulations will beimplemented and enforced. We continue to evaluate the necessary steps for compliance with applicable regulations. To comply with applicable regulations,we have and will continue to incur significant expense and allocate valuable internal resources to manage compliance-related issues. In addition, suchregulations could restrict our ability to expand or equip our facilities, or could require us to acquire costly equipment or to incur other significant expenses tocomply with the regulations. For example, the Restriction on the Use of Certain Hazardous Substances in Electrical and Electronic Equipment Directive, orRoHS, and the Waste Electrical and Electronic Equipment Directive, or WEEE, enacted in the European Union, regulate the use of certain hazardoussubstances in, and require the collection, reuse, and recycling of waste from, products we manufacture. Certain of our products sold in these countries aresubject to WEEE and RoHS. These and similar regulations that have been or are in the process of being enacted in other countries may require us to redesignour products, use different types of materials in certain components, or source alternative components to ensure compliance with applicable standards, andmay reduce the availability of parts and components used in our products by negatively impacting our suppliers’ ability to source parts and components in atimely and cost-effective manner.Any such redesigns, required use of alternative materials, or limited availability of parts and components used in our products may detrimentallyimpact the performance of our products, add greater testing lead times for product introductions, reduce our product margins, or limit the markets for ourproducts, and if we fail to comply with any present and future regulations, we could be subject to future fines, penalties, and restrictions, such as thesuspension of manufacturing of our products or a prohibition on the sale of products we manufacture. Any of the foregoing could adversely affect ourbusiness, financial condition, or results of operations.If we fail to maintain effective internal control over financial reporting in the future, the accuracy and timing of our financial reporting may beimpaired, which could adversely affect our business and our stock price.The Sarbanes-Oxley Act requires, among other things, that we maintain effective internal control over financial reporting and disclosure controls andprocedures. In particular, we must perform system and process evaluation and testing of our internal control over financial reporting to allow management toreport on the effectiveness of our internal control over financial reporting, as required by Section 404 of the Sarbanes-Oxley Act. Our testing may revealdeficiencies in our internal control over financial reporting that are deemed to be material weaknesses.Our compliance with Section 404 requires that we incur substantial accounting expense and expend significant management time on compliance-related issues. We currently do not have an internal audit group, and we continue to evaluate our need for additional accounting and financial staff withappropriate public company experience and technical accounting knowledge. Moreover, if we do not comply with the requirements of Section 404, or if weor our independent registered public accounting firm identify deficiencies in our internal control over financial reporting that are deemed to be materialweaknesses, the market price of our stock could decline and we could be subject to sanctions or investigations by the Nasdaq Global Select Market (Nasdaq),the SEC, or other regulatory authorities, which would require additional financial and management resources.Impairment of our goodwill or other intangible assets could materially and adversely affect our business, operating results, and financial condition.As of December 31, 2018, we had approximately $165.9 million of goodwill and net intangible assets, including approximately $104.1 million ofgoodwill and $61.8 million of net intangible assets. These assets represent a significant portion of the assets recorded on our consolidated balance sheet andrelate primarily to our acquisition of DVS Sciences, Inc., or DVS,24in February 2014. In addition, if in the future we acquire additional businesses, technologies, or other intangible assets, a substantial portion of the value ofsuch assets may be recorded as goodwill or intangible assets.The carrying amounts of goodwill and intangible assets are affected whenever events or changes in circumstances indicate that their carrying amountsmay not be recoverable. We review goodwill and indefinite lived intangible assets for impairment at least annually and more frequently under certaincircumstances. Other intangible assets that are deemed to have finite useful lives will continue to be amortized over their useful lives but must be reviewedfor impairment when events or changes in circumstances indicate that the carrying amount of these assets may not be recoverable. Events or changes incircumstances that could affect the likelihood that we will be required to recognize an impairment charge include declines in our stock price or marketcapitalization, declines in our market share or revenues, an increase in our losses, rapid changes in technology, failure to achieve the benefits of capacityincreases and utilization, significant litigation arising out of an acquisition, or other matters. In particular, these or other adverse events or changes incircumstances may affect the estimated undiscounted future operating cash flows expected to be derived from our goodwill and intangible assets. Anyimpairment charges could have a material adverse effect on our operating results and net asset value in the quarter in which we recognize the impairmentcharge. We cannot provide assurances that we will not in the future be required to recognize impairment charges.Our future capital needs are uncertain and we may need to raise additional funds in the future, which may cause dilution to stockholders or may beupon terms that are not favorable to us.We believe that our existing cash and cash equivalents and availability under the Revolving Credit Facility will be sufficient to meet our anticipatedcash requirements for at least the next 18 months. We have continued to experience losses and, if that trend continues, we may need to seek additionalsources of financing. In addition, we may need to raise substantial additional capital for various purposes, including:•expanding the commercialization of our products;•funding our operations;•furthering our research and development; and•acquiring other businesses or assets and licensing technologies.Our future funding requirements will depend on many factors, including:•market acceptance of our products;•the cost of our research and development activities;•the cost of filing and prosecuting patent applications;•the cost of defending any litigation including intellectual property, employment, contractual or other litigation;•the cost and timing of regulatory clearances or approvals, if any;•the cost and timing of establishing additional sales, marketing, and distribution capabilities;•the cost and timing of establishing additional technical support capabilities;•fluctuations in cash demands (e.g., due to interest payments or payouts under existing cash compensation plans);•sales variability through the year-end timing of related cash collections:•the effectiveness of our recent efficiency and cost-savings initiatives;•the effect of competing technological and market developments; and•the extent to which we acquire or invest in businesses, products, and technologies, although we currently have no commitments or agreementsrelating to any of these types of transactions.To the extent we draw on our $15.0 million revolving senior credit facility (the “2018 Facility”) or otherwise incur additional indebtedness, the risksdescribed above could increase. Further, if we increase our indebtedness, our actual cash requirements in the future may be greater than expected. Our cashflow from operations may not be sufficient to repay all of the outstanding debt as it becomes due, and we cannot assure you that we will be able to obtainadditional funds on acceptable terms, or at all. If we raise additional funds by issuing equity securities, our stockholders may experience dilution. Debtfinancing in addition to the 2018 Facility, if available, may involve covenants restricting our operations or our ability to incur additional debt. Anyadditional debt or equity financing that we raise may contain terms that are not favorable to us or our stockholders. If we raise additional funds throughcollaboration and licensing arrangements with third parties, it may be necessary to relinquish some rights to our technologies or our products, or grantlicenses on terms that are not favorable to us. If we do not have or are unable to raise adequate funds, we may have to liquidate some or all of our assets, delaydevelopment or commercialization of our products, or license to third parties the rights to commercialize products or technologies that we25would otherwise seek to commercialize. We also may have to reduce marketing, customer support, research and development, or other resources devoted toour products, or cease operations. Any of these factors could harm our operating results.If we fail to comply with the covenants and other obligations under our credit facility, the lenders may be able to accelerate amounts owed under thefacilities and may foreclose upon the assets securing our obligations.In August 2018, we entered into the Revolving Credit Facility. The Revolving Credit Facility provides for secured revolving loans in an aggregateamount of up to $15.0 million. The Revolving Credit Facility is secured by substantially all of our assets, other than intellectual property. The RevolvingCredit Facility contains customary affirmative and negative covenants which, unless waived by the bank, limit our ability to, among other things, incuradditional indebtedness, grant liens, make investments, repurchase stock, pay dividends, transfer assets, enter into affiliate transactions, undergo a change ofcontrol, or engage in merger and acquisition activity, including merging or consolidating with a third party. If we fail to comply with the covenants and ourother obligations under the 2018 Facility, the lenders would be able to accelerate the required repayment of amounts due under the 2018 Credit Agreementand, if they are not repaid, could foreclose upon the assets securing our obligations under the 2018 Facility.We are subject to risks related to taxation in multiple jurisdictions and if taxing authorities disagree with our interpretations of existing tax laws orregulations, our effective income tax rate could be adversely affected and we could have additional tax liability.We are subject to income taxes in both the United States and certain foreign jurisdictions. Significant judgments based on interpretations of existingtax laws or regulations are required in determining the provision for income taxes. For example, we have made certain interpretations of existing tax laws orregulations based upon the operations of our business internationally and we have implemented intercompany agreements based upon these interpretationsand related transfer pricing analyses. If the U.S. Internal Revenue Service or other taxing authorities disagree with the positions, our effective income tax ratecould be adversely affected and we could have additional tax liability, including interest and penalties. We recently completed a review of our Europeancorporate structure and tax positions and, based upon our existing business operations, we restructured our European intercompany transactions, whichincreased our income tax liability. From time to time, we may review our corporate structure and tax positions in other international jurisdictions and suchreview may result in additional changes to how we structure our international business operations, which may adversely impact our effective income tax rate.Our effective income tax rate could also be adversely affected by changes in the mix of earnings in tax jurisdictions with different statutory tax rates, changesin the valuation of deferred tax assets and liabilities, changes in existing tax laws or tax rates, changes in the level of non-deductible expenses (includingshare-based compensation), changes in our future levels of research and development spending, mergers and acquisitions, or the result of examinations byvarious tax authorities. Legislation commonly referred to as the 2017 Tax Cuts and Jobs Act was enacted in the United States on December 22, 2017 andintroduced a number of changes to U.S. federal income tax, the consequences to us of which have not yet been fully determined and which could havematerial impact on the value of our deferred tax assets, could result in significant one-time charges in the current or future taxable years, and could increaseour future U.S. tax expense. Payment of additional amounts as a result of changes in applicable tax law or upon final adjudication of any disputes could havea material impact on our results of operations and financial position.Our ability to use net operating loss carryforwards to offset future taxable income for U.S. federal income tax purposes and other tax benefits may belimited.Section 382 of the Internal Revenue Code of 1986, as amended, referred to as the “Code,” imposes an annual limitation on the amount of taxableincome that may be offset if a corporation experiences an “ownership change” as defined in Section 382 of the Code. An ownership change occurs when acompany’s “five-percent shareholders” (as defined in Section 382 of the Code) collectively increase their ownership in the company by more than 50percentage points (by value) over a rolling three-year period. Additionally, various states have similar limitations on the use of state net operating losses,referred to as our NOLs, following an ownership change.If we experience an ownership change, our ability to use our NOLs, any loss or deduction attributable to a “net unrealized built-in loss” and other taxattributes, which we refer to as tax benefits, could be substantially limited, and the timing of the usage of the tax benefits could be substantially delayed,which could significantly impair the value of the tax benefits. There is no assurance that we will be able to fully utilize the tax benefits and we could berequired to record an additional valuation allowance related to the amount of the tax benefits that may not be realized, which could adversely impact ourresults of operations.We believe that these tax benefits are a valuable asset for us. However, legislation commonly known as the 2017 Tax Cuts and Jobs Act includes adecrease in the U.S. federal corporate income tax rate from 35% to 21%, and our tax benefits were26revalued at the newly enacted rate. We do not expect this to have a material impact on our financial statements because we currently maintain a full valuationallowance on our U.S. deferred tax assets; however, this reduction in the U.S. federal corporate income tax rate results in a corresponding reduction in thevalue of our tax benefits. On November 21, 2016, our board of directors approved a tax benefit preservation plan, or Tax Benefit Preservation Plan, in aneffort to protect our tax benefits during the effective period of the tax benefit preservation plan. Our board of directors elected to let the Tax BenefitPreservation Plan expire in August 2017 based on its determination, in consultation with our management and tax advisors, that our NOLs were not atmaterial risk of limitation based on an ownership change pursuant to Section 382. Our board of directors will continue to monitor our NOLs, however, andcould elect to adopt a similar plan if it believes a potential risk exists that our NOLs could be limited. Any future tax benefit preservation plan could make itmore difficult for a third party to acquire, or could discourage a third party from acquiring, us or a large block of our common stock.Adverse conditions in the global economy and disruption of financial markets may significantly harm our revenue, profitability, and results ofoperations.The global credit and financial markets have in recent years experienced volatility and disruptions, including diminished liquidity and creditavailability, increased concerns about inflation and deflation, and the downgrade of U.S. debt and exposure risks on other sovereign debts, decreasedconsumer confidence, lower economic growth, volatile energy costs, increased unemployment rates, and uncertainty about economic stability. In addition,certain geopolitical events, including the prolonged shutdown of the United States government and the ongoing negotiation of the United Kingdom’swithdrawal from the European Union, have caused significant economic, market, political and regulatory uncertainty in some of our markets. Volatility anddisruption of financial markets could limit our customers’ ability to obtain adequate financing or credit to purchase and pay for our products in a timelymanner or to maintain operations, which could result in a decrease in sales volume that could harm our results of operations. General concerns about thefundamental soundness of domestic and international economies may also cause our customers to reduce their purchases. Changes in governmental banking,monetary, and fiscal policies to address liquidity and increase credit availability may not be effective. Significant government investment and allocation ofresources to assist the economic recovery of sectors which do not include our customers may reduce the resources available for government grants and relatedfunding for life science, Ag-Bio, and clinical research and development. Continuation or further deterioration of these financial and macroeconomicconditions could significantly harm our sales, profitability, and results of operations.If we are unable to expand our direct sales and marketing force or distribution capabilities to adequately address our customers’ needs, our businessmay be adversely affected.We may not be able to market, sell, and, distribute our products effectively enough to support our planned growth. We sell our products primarilythrough our own sales force and through distributors in certain territories. Our future sales will depend in large part on our ability to continue to develop andsubstantially expand our direct sales force and to increase the scope of our marketing efforts. Our products are technically complex and used for highlyspecialized applications. As a result, we believe it is necessary to continue to develop a direct sales force that includes people with specific scientificbackgrounds and expertise, and a marketing group with technical sophistication. Competition for such employees is intense. In addition, we haveexperienced significant changes in our sales organization in recent quarters due to reorganizations and changes in leadership. We may not be able to attractand retain personnel or be able to build an efficient and effective sales and marketing force, which would negatively impact sales of our products and reduceour revenue and profitability.In addition, we may continue to enlist one or more sales representatives and distributors to assist with sales, distribution, and customer support globallyor in certain regions of the world. If we do seek to enter into such arrangements, we may not be successful in attracting desirable sales representatives anddistributors, or we may not be able to enter into such arrangements on favorable terms. If our sales and marketing efforts, or those of any third-party salesrepresentatives and distributors, are not successful, our technologies and products may not gain market acceptance, which would materially and adverselyimpact our business operations.If we seek to implement a company-wide implementation of an enterprise resource planning, or ERP, system, such implementation could adverselyaffect our business and results of operations or the effectiveness of internal control over financial reporting.We have considered implementing a company-wide ERP system to handle the business and financial processes within our operations and corporatefunctions. ERP implementations are complex and time-consuming projects that involve substantial expenditures on system software and implementationactivities that can continue for several years. ERP implementations also require transformation of business and financial processes in order to reap thebenefits of the ERP system. If we decide to implement a company-wide ERP system, our business and results of operations could be adversely affected if weexperience operating problems and/or cost overruns during the ERP implementation process, or if the ERP system and the associated27process changes do not give rise to the benefits that we expect. If we do not effectively implement the ERP system as planned or if the system does notoperate as intended, our business, results of operations, and internal controls over financial reporting could be adversely affected.Changes in accounting principles, or interpretations thereof, could have a significant impact on our financial position and results of operations.We prepare our consolidated financial statements in accordance with accounting principles generally accepted in the United States of America, referredto as U.S. GAAP. These principles are subject to interpretation by the SEC and various bodies formed to interpret and create appropriate accountingprinciples. A change in these principles can have a significant effect on our reported results and may even retroactively affect previously reportedtransactions. Additionally, the adoption of new or revised accounting principles may require that we make significant changes to our systems, processes andcontrols.For example, the U.S.-based Financial Accounting Standards Board, referred to as FASB, is currently working together with the InternationalAccounting Standards Board, referred to IASB, on several projects to further align accounting principles and facilitate more comparable financial reportingbetween companies who are required to follow U.S. GAAP under SEC regulations and those who are required to follow International Financial ReportingStandards outside of the United States. These efforts by the FASB and IASB may result in different accounting principles under U.S. GAAP that may result inmaterially different financial results for us in areas including, but not limited to, principles for recognizing revenue and lease accounting. Additionally,significant changes to U.S. GAAP resulting from the FASB’s and IASB’s efforts may require that we change how we process, analyze and report financialinformation and that we change financial reporting controls. Additionally, the FASB issued new guidance (ASU 2014-09) Revenue from Contracts withCustomers (Topic 606) which supersedes nearly all existing U.S. GAAP revenue recognition guidance. The new guidance was effective for our fiscal year2018. We adopted ASU 2014-09 in the first quarter of 2018 using the modified retrospective method. Under the modified retrospective method, periods priorto the adoption of ASU 2014-09 are not restated and the cumulative effect of initially applying the new standard is reflected in the opening balance ofretained earnings as of January 1, 2018. To date, the adoption has not had a material impact on our consolidated financial statements. Additional disclosuresare required for significant differences between the reported results under the new standard and those that would have been reported under the legacystandard, which required us to make certain changes to our business processes and controls to support revenue recognition and disclosure under the newstandard.The FASB also issued Accounting Standards Update (ASU) 2016-02, Leases (Topic 842). The core principle is that lessees should recognize the assetsand liabilities arising from leases on the balance sheet. Under the new standard, lessees will be required to recognize lease assets and liabilities for all leases,with certain exceptions, on their balance sheets. We will adopt ASU 2016-02 as of January 1, 2019. We continue to evaluate the initial cumulative effect ofthe new standard as well as on our ongoing financial reporting. We continue to identify the appropriate changes to our business processes, systems, andcontrols to support the new lease standards and the required disclosures under the new standard.It is not clear if or when these potential changes in accounting principles may become effective, whether we have the proper systems and controls inplace to accommodate such changes and the impact that any such changes may have on our financial position and results of operations.We have a significant amount of outstanding indebtedness, and our financial condition and results of operations could be adversely affected if we do notefficiently manage our liabilities.We have significant outstanding convertible debt, and may be required to repay, refinance or restructure a portion of such debt before 2021. As ofDecember 31, 2018, we had outstanding $150.00 million aggregate principal amount of our 2018 Notes and $51.3 million aggregate principal amount of our2014 Notes. Subsequent to December 31, 2018, all of the 2018 Notes have since been converted into shares of our common stock pursuant to conversionnotices received from the holders of such 2018 Notes and in connection with the Issuer’s Conversion Option and no 2018 Notes remain outstanding. Pleasesee the section entitled “Recent Developments” in Part II, Item 7 of this Form 10-K for more information on the conversion of the 2018 Notes.The 2014 Notes will mature on February 1, 2034, unless earlier converted, redeemed, or repurchased in accordance with the terms of the 2014 Notes.Holders of the 2014 Notes may require us to repurchase all or a portion of their 2014 Notes on each of February 6, 2021, February 6, 2024, and February 6,2029 at a repurchase price in cash equal to 100% of the principal amount of the Notes plus accrued and unpaid interest. If we undergo a fundamental change,as defined in the terms of each of the applicable series of Notes, holders of the 2014 Notes may require us to repurchase the 2014 Notes in whole or in part forcash at a repurchase price equal to 100% of the principal amount of the 2014 Notes plus accrued and unpaid interest. If we refinance the debt owed under the2014 Notes, we may issue additional convertible notes or other debt, which could include additional company obligations and represent more dilution toexisting stockholders and noteholders.28This significant amount of debt has important risks to us and our investors, including:•requiring a portion of our cash flow from operations to make interest payments on this debt;•increasing our vulnerability to general adverse economic and industry conditions;•reducing the cash flow available to fund capital expenditures and other corporate purposes and to grow our business;•limiting our flexibility in planning for, or reacting to, changes in our business and the industry; and•limiting our ability to borrow additional funds as needed or take advantage of business opportunities as they arise.In addition, to the extent we draw on our Revolving Credit Facility or otherwise incur additional indebtedness, the risks described above couldincrease. Further, if we increase our indebtedness, our actual cash requirements in the future may be greater than expected. Our cash flow from operations maynot be sufficient to repay all of the outstanding debt as it becomes due, and we may not be able to borrow money, sell assets or otherwise raise funds onacceptable terms, or at all, to refinance our debt.Risks Related to Intellectual PropertyOur ability to protect our intellectual property and proprietary technology through patents and other means is uncertain.Our commercial success depends in part on our ability to protect our intellectual property and proprietary technologies. We rely on patent protection,where appropriate and available, as well as a combination of copyright, trade secret, and trademark laws, and nondisclosure, confidentiality, and othercontractual restrictions to protect our proprietary technology. However, these legal means afford only limited protection and may not adequately protect ourrights or permit us to gain or keep any competitive advantage. We apply for patents covering our products and technologies and uses thereof, as we deemappropriate. However, we may fail to apply for patents on important products and technologies in a timely fashion or at all. Our pending U.S. and foreignpatent applications may not issue as patents or may not issue in a form that will be sufficient to protect our proprietary technology and gain or keep ourcompetitive advantage. Any patents we have obtained or do obtain may be subject to re-examination, reissue, opposition, or other administrative proceeding,or may be challenged in litigation, and such challenges could result in a determination that the patent is invalid or unenforceable. In addition, competitorsmay be able to design alternative methods or devices that avoid infringement of our patents. Both the patent application process and the process of managingpatent disputes can be time consuming and expensive.Furthermore, the laws of some foreign countries may not protect our intellectual property rights to the same extent as do the laws of the United States,and many companies have encountered significant problems in protecting and defending such rights in foreign jurisdictions. Proceedings to enforce ourpatent rights in foreign jurisdictions could result in substantial cost and divert our efforts and attention from other aspects of our business. Changes in eitherthe patent laws or in interpretations of patent laws in the United States or other countries may diminish the value of our intellectual property. We cannotpredict the breadth of claims that may be allowed or enforced in our patents or in third-party patents. For example:•We might not have been the first to make the inventions covered by each of our pending patent applications;•We might not have been the first to file patent applications for these inventions;•The patents of others may have an adverse effect on our business; and•Others may independently develop similar or alternative products and technologies or duplicate any of our products and technologies.To the extent our intellectual property, including licensed intellectual property, offers inadequate protection, or is found to be invalid orunenforceable, our competitive position and our business could be adversely affected.29We may be involved in lawsuits to protect or enforce our patents and proprietary rights, to determine the scope, coverage and validity of others’proprietary rights, or to defend against third party claims of intellectual property infringement, any of which could be time-intensive and costly andmay adversely impact our business or stock price.Litigation may be necessary for us to enforce our patent and proprietary rights, determine the scope, coverage, and validity of others’ proprietary rights,and/or defend against third party claims of intellectual property infringement against us as well as against our suppliers, distributors, customers, and otherentities with whom we do business. Litigation could result in substantial legal fees and could adversely affect the scope of our patent protection. Theoutcome of any litigation or other proceeding is inherently uncertain and might not be favorable to us, and we might not be able to obtain licenses totechnology that we require. Even if such licenses are obtainable, they may not be available at a reasonable cost. We could therefore incur substantial costsrelated to royalty payments for licenses obtained from third parties, which could negatively affect our product margins or financial position. Further, wecould encounter delays in product introductions, or interruptions in product sales, as we develop alternative methods or products.As we move into new markets and applications for our products, incumbent participants in such markets may assert their patents and other proprietaryrights against us as a means of impeding our entry into such markets or as a means to extract substantial license and royalty payments from us. Ourcommercial success may depend in part on our non-infringement of the patents or proprietary rights of third parties. Numerous significant intellectualproperty issues have been litigated, and will likely continue to be litigated, between existing and new participants in our existing and targeted markets. Forexample, some of our products provide for the testing and analysis of genetic material, and patent rights relating to genetic materials remain a developingarea of patent law. A recent U.S. Supreme Court decision held, among other things, that claims to isolated genomic DNA occurring in nature are not patenteligible, while claims relating to synthetic DNA may be patent eligible. We expect the ruling will result in additional litigation in our industry. In addition,third parties may assert that we are employing their proprietary technology without authorization, and if they are successful in making such claims, we maybe forced to enter into license agreements, pay additional royalties or license fees, or enter into settlements that include monetary obligations or restrictionson our business.Our customers have been sued for various claims of intellectual property infringement in the past, and we expect that our customers will be involved inadditional litigation in the future. In particular, our customers may become subject to lawsuits claiming that their use of our products infringes third-partypatent rights, and we could become subject to claims that we contributed to or induced our customer’s infringement. In addition, our agreements with some ofour suppliers, distributors, customers, and other entities with whom we do business may require us to defend or indemnify these parties to the extent theybecome involved in infringement claims against us, including the claims described above. We could also voluntarily agree to defend or indemnify thirdparties in instances where we are not obligated to do so if we determine it would be important to our business relationships. If we are required or agree todefend or indemnify any of these third parties in connection with any infringement claims, we could incur significant costs and expenses that could adverselyaffect our business, operating results, or financial condition.We may be subject to damages resulting from claims that we or our employees have wrongfully used or disclosed alleged trade secrets of ouremployees’ former employers or other institutions or third parties with whom such employees may have been previously affiliated.Many of our employees were previously employed at universities or other life science or Ag-Bio companies, including our competitors or potentialcompetitors. In the future, we may become subject to claims that our employees, or we, have inadvertently or otherwise used or disclosed trade secrets or otherproprietary information of their former employers or other third parties or institutions with whom our employees may have been previously affiliated.Litigation may be necessary to defend against these claims. For example, we were a defendant in litigation brought against us and one of our non-executiveemployees by Thermo Fisher Scientific Inc. (Thermo) alleging, among other claims, misappropriation of proprietary information and breach of contractualand fiduciary obligations. While we resolved our dispute with Thermo in July 2017, if we fail in defending against similar claims brought in the future wecould be subject to injunctive relief against us. A loss of key research personnel work product could hamper or prevent our ability to commercialize certainpotential products or a loss of or inability to hire key marketing, sales or research and development personnel could adversely affect our future productdevelopment, sales and revenues, any of which could severely harm our business. Even if we are successful in defending against any similar claims brought inthe future, litigation could result in substantial costs and be a distraction to management.30We depend on certain technologies that are licensed to us. We do not control these technologies and any loss of our rights to them could prevent us fromselling our products, which would have an adverse effect on our business.We rely on licenses in order to be able to use various proprietary technologies that are material to our business, including our core IFC, multi-layer softlithography, and mass cytometry technologies. In some cases, we do not control the prosecution, maintenance, or filing of the patents to which we holdlicenses, or the enforcement of these patents against third parties. Additionally, our business and product development plans anticipate and may substantiallydepend on future in-license agreements with additional third parties, some of which are currently in the early discussion phase. For example, FluidigmCanada Inc., or Fluidigm Canada, an Ontario corporation and wholly-owned subsidiary of Fluidigm Sciences, was party to an interim license agreement, nowexpired, with Nodality, Inc., or Nodality, under which Nodality granted Fluidigm Canada a worldwide, non-exclusive, research use only, royalty bearinglicense to certain cytometric reagents, instruments, and other products. While we were able to secure a license under a new license agreement with Nodality,we cannot provide assurances that we will always be able to obtain suitable license rights to technologies or intellectual property of other third parties onacceptable terms, if at all.In-licensed intellectual property rights that are fundamental to the business being operated present numerous risks and limitations. For example, all or aportion of the license rights granted may be limited for research use only, and in the event we attempt to expand into diagnostic applications, we would berequired to negotiate additional rights, which may not be available to us on commercially reasonable terms, if at all.Our rights to use the technology we license are also subject to the negotiation and continuation of those licenses. Certain of our licenses containprovisions that allow the licensor to terminate the license upon specific conditions. Our rights under the licenses are subject to our continued compliancewith the terms of the license, including the payment of royalties due under the license. Because of the complexity of our products and the patents we havelicensed, determining the scope of the license and related royalty obligation can be difficult and can lead to disputes between us and the licensor. Anunfavorable resolution of such a dispute could lead to an increase in the royalties payable pursuant to the license. If a licensor believed we were not payingthe royalties due under the license or were otherwise not in compliance with the terms of the license, the licensor might attempt to revoke the license. If suchan attempt were successful and the license is terminated, we might be barred from marketing, producing, and selling some or all of our products, which wouldhave an adverse effect on our business. Potential disputes between us and one of our existing licensors concerning the terms or conditions of the applicablelicense agreement could result, among other risks, in substantial management distraction; increased expenses associated with litigation or efforts to resolvedisputes; substantial customer uncertainty concerning the direction of our product lines; potential infringement claims against us and/or our customers,which could include efforts by a licensor to enjoin sales of our products; customer requests for indemnification by us; and, in the event of an adversedetermination, our inability to operate our business as currently operated. Termination of material license agreements could prevent us from manufacturingand selling our products unless we can negotiate new license terms or develop or acquire alternative intellectual property rights that cover or enable similarfunctionality. Any of these factors would be expected to have a material adverse effect on our business, operating results, and financial condition and couldresult in a substantial decline in our stock price.We are subject to certain manufacturing restrictions related to licensed technologies that were developed with the financial assistance of U.S.governmental grants.We are subject to certain U.S. government regulations because we have licensed technologies that were developed with U.S. government grants. Inaccordance with these regulations, these licenses provide that products embodying the technologies are subject to domestic manufacturing requirements. Ifthis domestic manufacturing requirement is not met, the government agency that funded the relevant grant is entitled to exercise specified rights, referred toas “march-in rights,” which if exercised would allow the government agency to require the licensors or us to grant a non-exclusive, partially exclusive, orexclusive license in any field of use to a third party designated by such agency. All of our microfluidic systems revenue is dependent upon the availability ofour IFCs, which incorporate technology developed with U.S. government grants. Our genomics instruments, including microfluidic systems, and IFCs aremanufactured at our facility in Singapore. The federal regulations allow the funding government agency to grant, at the request of the licensors of suchtechnology, a waiver of the domestic manufacturing requirement. Waivers may be requested prior to any government notification. We have assisted thelicensors of these technologies with the analysis of the domestic manufacturing requirement, and, in December 2008, the sole licensor subject to therequirement applied for a waiver of the domestic manufacturing requirement with respect to the relevant patents licensed to us by this licensor. In July 2009,the funding government agency granted the requested waiver of the domestic manufacturing requirement for a three-year period commencing in July 2009. InJune 2012, the licensor requested a continued waiver of the domestic manufacturing requirement with respect to the relevant patents, but the governmentagency has not yet taken any action in response to this request. If the government agency does not grant the requested waiver or the government fails to grantadditional waivers of such requirement that may be sought in the future, then the U.S. government could exercise its march-in31rights with respect to the relevant patents licensed to us. In addition, the license agreement under which the relevant patents are licensed to us containsprovisions that obligate us to comply with this domestic manufacturing requirement. We are not currently manufacturing instruments and IFCs in the UnitedStates that incorporate the relevant licensed technology. If our lack of compliance with this provision constituted a material breach of the license agreement,the license of the relevant patents could be terminated or we could be compelled to relocate our manufacturing of microfluidic systems and IFCs to theUnited States to avoid or cure a material breach of the license agreement. Any of the exercise of march-in rights, the termination of our license of the relevantpatents or the relocation of our manufacturing of microfluidic systems and IFCs to the United States could materially adversely affect our business, operationsand financial condition.We are subject to certain obligations and restrictions relating to technologies developed in cooperation with Canadian government agencies.Some of our Canadian research and development is funded in part through government grants and by government agencies. The intellectual propertydeveloped through these projects is subject to rights and restrictions in favor of government agencies and Canadians generally. In most cases the governmentagency retains the right to use intellectual property developed through the project for non-commercial purposes and to publish the results of researchconducted in connection with the project. This may increase the risk of public disclosure of information relating to our intellectual property, includingconfidential information, and may reduce its competitive advantage in commercializing intellectual property developed through these projects. In certainprojects, we have also agreed to use commercially reasonable efforts to commercialize intellectual property in Canada, or more specifically in the province ofOntario, for the economic benefit of Canada and the province of Ontario. These restrictions will limit our choice of business and manufacturing locations,business partners and corporate structure and may, in certain circumstances, restrict our ability to achieve maximum profitability and cost efficiency from theintellectual property generated by these projects. In one instance, a dispute with the applicable government funded entity may require mediation, whichcould lead to unanticipated delays in our commercialization efforts to that project. One of our Canadian government funded projects is also subject to certainlimited “march-in” rights in favor of the government of the Province of Ontario, under which we may be required to grant a license to our intellectualproperty, including background intellectual property developed outside the scope of the project, to a responsible applicant on reasonable terms incircumstances where the government determines that such a license is necessary in order to alleviate emergency or extraordinary health or safety needs or forpublic use. In addition, we must provide reasonable assistance to the government in obtaining similar licenses from third parties required in connection withthe use of its intellectual property. Instances in which the government of the Province of Ontario has exercised similar “march-in” rights are rare; however, theexercise of such rights could materially adversely affect our business, operations and financial condition.Risks Related to Our Common StockOur stock price may fluctuate significantly, particularly if holders of substantial amounts of our stock attempt to sell, and holders may have difficultyselling their shares based on current trading volumes of our stock. In addition, numerous other factors could result in substantial volatility in thetrading price of our stock.Our stock is currently traded on Nasdaq, but we can provide no assurance that we will be able to maintain an active trading market on Nasdaq or anyother exchange in the future. The trading volume of our stock tends to be low relative to our total outstanding shares, and we have several stockholders whohold substantial blocks of our stock. As of December 31, 2018, we had 49,338,473 shares of common stock outstanding, and stockholders holding at least 5%of our stock, individually or with affiliated persons or entities, collectively beneficially owned or controlled approximately 46.6%of such shares and onestockholder beneficially owned 25.3% of our outstanding common stock. Sales of large numbers of shares by any of our large stockholders could adverselyaffect our trading price, particularly given our relatively small historic trading volumes. If stockholders holding shares of our common stock sell, indicate anintention to sell, or if it is perceived that they will sell, substantial amounts of their common stock in the public market, the trading price of our commonstock could decline. Moreover, if there is no active trading market or if the volume of trading is limited, holders of our common stock may have difficultyselling their shares. In addition, the concentration of ownership of our outstanding common stock (approximately 46.6% held by our top three stockholders)means that a relatively small number of stockholders have significant control over the outcomes of stockholder voting.In addition, the trading price of our common stock may be highly volatile and could be subject to wide fluctuations in response to various factors, someof which are beyond our control. These factors include:•actual or anticipated quarterly variation in our results of operations or the results of our competitors;32•announcements or communications by us or our competitors relating to, among other things, new commercial products, technological advances,significant contracts, commercial relationships, capital commitments, acquisitions or sales of businesses, and/or misperceptions in or speculationby the market regarding such announcements or communications;•issuance of new or changed securities analysts’ reports or recommendations for our stock;•developments or disputes concerning our intellectual property or other proprietary rights;•commencement of, or our involvement in, litigation;•market conditions in the life science, Ag-Bio, and CRO sectors;•failure to complete significant sales;•manufacturing disruptions that could occur if we were unable to successfully expand our production in our current or an alternative facility;•any future sales of our common stock or other securities in connection with raising additional capital or otherwise;•any major change to the composition of our board of directors or management; and•general economic conditions and slow or negative growth of our markets.The stock market in general, and market prices for the securities of technology-based companies like ours in particular, have from time to timeexperienced volatility that often has been unrelated to the operating performance of the underlying companies. These broad market and industry fluctuationsmay adversely affect the market price of our common stock regardless of our operating performance. In several recent situations where the market price of astock has been volatile, holders of that stock have instituted securities class action litigation against the company that issued the stock. If any of ourstockholders were to bring a lawsuit against us, the defense and disposition of the lawsuit could be costly and divert the time and attention of ourmanagement and harm our operating results.If securities or industry analysts publish unfavorable research about our business or cease to cover our business, our stock price and/or trading volumecould decline.The trading market for our common stock may rely, in part, on the research and reports that equity research analysts publish about us and our business.We do not have any control of the analysts or the content and opinions included in their reports. The price of our stock could decline if one or more equityresearch analysts downgrade our stock or issue other unfavorable commentary or research. If one or more equity research analysts ceases coverage of ourcompany or fails to publish reports on us regularly, demand for our stock could decrease, which in turn could cause our stock price or trading volume todecline.Anti-takeover provisions in our charter documents and under Delaware law could make an acquisition of us, which may be beneficial to ourstockholders, more difficult and may prevent attempts by our stockholders to replace or remove our current management and limit the market price ofour common stock.Provisions in our certificate of incorporation and bylaws may have the effect of delaying or preventing a change of control or changes in ourmanagement, including provisions that:•authorize our board of directors to issue, without further action by the stockholders, up to 10,000,000 shares of undesignated preferred stock;•require that any action to be taken by our stockholders be effected at a duly called annual or special meeting and not by written consent;•specify that special meetings of our stockholders can be called only by our board of directors, the chairman of the board, the chief executive officeror the president;•establish an advance notice procedure for stockholder approvals to be brought before an annual meeting of our stockholders, including proposednominations of persons for election to our board of directors;33•establish that our board of directors is divided into three classes, Class I, Class II, and Class III, with each class serving staggered three-year terms;•provide that our directors may be removed only for cause;•provide that vacancies on our board of directors may be filled only by a majority of directors then in office, even though less than a quorum;•specify that no stockholder is permitted to cumulate votes at any election of directors; and•require a super-majority of votes to amend certain of the above-mentioned provisions.These provisions may frustrate or prevent any attempts by our stockholders to replace or remove our current management by making it more difficultfor stockholders to replace members of our board of directors, which is responsible for appointing the members of our management. In addition, because weare incorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporation Law, which limits the ability ofstockholders owning in excess of 15% of our outstanding voting stock to merge or combine with us.We have never paid cash dividends on our capital stock, and we do not anticipate paying any cash dividends in the foreseeable future.We have paid no cash dividends on any of our classes of capital stock to date and currently intend to retain our future earnings to fund the developmentand growth of our business. In addition, we cannot pay any cash dividends on any of our classes of common stock without approval from the lender under our2018 Credit Facility, and may become subject to covenants under future debt arrangements that place restrictions on our ability to pay dividends. As a result,capital appreciation, if any, of our common stock will be stockholders’ sole source of gain for the foreseeable future.Risks Related to Our Outstanding Convertible NotesOur outstanding convertible notes are effectively subordinated to our secured debt and any liabilities of our subsidiaries.Our outstanding 2014 Notes rank:•senior in right of payment to any of our indebtedness that is expressly subordinated in right of payment to the 2014 Notes;•equal in right of payment to all of our liabilities that are not so subordinated;•effectively junior in right of payment to any of our secured indebtedness, including, but not limited to, any indebtedness under the RevolvingCredit Facility, to the extent of the value of the assets securing such indebtedness; and•structurally junior to all indebtedness and other liabilities (including trade payables) of our subsidiaries.In February 2014, we completed the offering of our 2014 Notes with an aggregate outstanding principal amount of $201.3 million. In March 2018, wecompleted an exchange of $150.0 million in aggregate principal amount of our 2014 Notes for $150.0 million in aggregate principal amount of our 2018Notes, leaving approximately $51.3 million in aggregate principal amount of 2014 Notes outstanding. Subsequent to December 31, 2018, all of the 2018Notes have since been converted into shares of our common stock pursuant to conversion notices received from the holders of such 2018 Notes and inconnection with the Issuer’s Conversion Option and no 2018 Notes remain outstanding. Please see the section entitled “Recent Developments” in Part II,Item 7 of this Form 10-K for more information on the conversion of the 2018 Notes. In the event of our bankruptcy, liquidation, reorganization, or otherwinding up, our assets that secure debt ranks senior in right of payment to 2014 Notes will be available to pay obligations on the 2014 Notes only after thesecured debt, including but not limited to, any indebtedness under the Revolving Credit Facility, has been repaid in full from these assets, and the assets ofour subsidiaries will be available to pay obligations on the 2014 Notes only after all claims senior to the 2014 Notes have been repaid in full. There may notbe sufficient assets remaining to pay amounts due on any or all of the 2014 Notes then outstanding. The indenture governing the 2014 Notes does notprohibit us from incurring additional senior debt or secured debt, nor does it prohibit our subsidiaries from incurring additional liabilities.34The 2014 Notes are our obligations only and some of our operations are conducted through, and a portion of our consolidated assets are held by, oursubsidiaries.The 2014 Notes are our obligations exclusively and are not guaranteed by any of our operating subsidiaries. A portion of our consolidated assets isheld by our subsidiaries. Accordingly, our ability to service our debt, including the 2014 Notes, depends in part on the results of operations of oursubsidiaries and upon the ability of such subsidiaries to provide us with cash, whether in the form of dividends, loans, or otherwise, to pay amounts due onour obligations, including the 2014 Notes. Our subsidiaries are separate and distinct legal entities and have no obligation, contingent or otherwise, to makepayments on the 2014 Notes or to make any funds available for that purpose. In addition, dividends, loans, or other distributions to us from such subsidiariesmay be subject to contractual and other restrictions and are subject to other business and tax considerations.Recent and future regulatory actions and other events may adversely affect the trading price and liquidity of the 2014 Notes.We expect that many investors in, and potential purchasers of, the 2014 Notes will employ, or seek to employ, a convertible arbitrage strategy withrespect to the 2014 Notes. Investors would typically implement such a strategy by selling short the common stock underlying the 2014 Notes anddynamically adjusting their short position while continuing to hold the 2014 Notes. Investors may also implement this type of strategy by entering intoswaps on our common stock in lieu of or in addition to short selling the common stock. As a result, any specific rules regulating equity swaps or short sellingof securities or other governmental action that interferes with the ability of market participants to effect short sales or equity swaps with respect to ourcommon stock could adversely affect the ability of investors in, or potential purchasers of, the 2014 Notes to conduct the convertible arbitrage strategy thatwe believe they will employ, or seek to employ, with respect to the 2014 Notes. This could, in turn, adversely affect the trading price and liquidity of the2014 Notes.The SEC and other regulatory and self-regulatory authorities have implemented various rules and taken certain actions, and may in the future adoptadditional rules and take other actions, that may impact those engaging in short selling activity involving equity securities (including our common stock).Such rules and actions include Rule 201 of SEC Regulation SHO, the adoption by the Financial Industry Regulatory Authority, Inc. and the nationalsecurities exchanges of a “Limit Up-Limit Down” program, the imposition of market-wide circuit breakers that halt trading of securities for certain periodsfollowing specific market declines, and the implementation of certain regulatory reforms required by the Dodd-Frank Wall Street Reform and ConsumerProtection Act of 2010. Although the direction and magnitude of the effect that Regulation SHO, FINRA, securities exchange rule changes, andimplementation of the Dodd-Frank Act may have on the trading price and the liquidity of the 2014 Notes will depend on a variety of factors, many of whichcannot be determined at the date of this report, past regulatory actions (such as certain emergency orders issued by the SEC in 2008 prohibiting short sales ofstock of certain financial services companies) have had a significant impact on the trading prices and liquidity of convertible debt instruments. Anygovernmental or regulatory action that restricts the ability of investors in, or potential purchasers of, the 2014 Notes to effect short sales of our common stock,borrow our common stock, or enter into swaps on our common stock or increases the costs of implementing an arbitrage strategy could adversely affect thetrading price and the liquidity of the 2014 Notes.Volatility in the market price and trading volume of our common stock could adversely impact the trading price of the 2014 Notes.The stock market in recent years has experienced significant price and volume fluctuations that have often been unrelated to the operating performanceof companies. The market price of our common stock could fluctuate significantly for many reasons, including in response to the risks described in thisreport, or for reasons unrelated to our operations, such as reports by industry analysts, investor perceptions or negative announcements by our customers,competitors or suppliers regarding their own performance, as well as industry conditions and general financial, economic and political instability. The marketprice of our common stock could also decline as a result of sales of a large number of shares of our common stock in the market, particularly sales by ourdirectors, executive officers, employees, and significant stockholders, and the perception that these sales could occur may also depress the market price of ourcommon stock. A decrease in the market price of our common stock would likely adversely impact the trading price of the 2014 Notes. The market price ofour common stock could also be affected by possible sales of our common stock by investors who view the 2014 Notes as a more attractive means of equityparticipation in us and by hedging or arbitrage trading activity that we expect to develop involving our common stock. This trading activity could, in turn,affect the trading price of the 2014 Notes.35We have incurred additional debt and may still incur substantially more debt or take other actions which would intensify the risks discussed above.We are not restricted under the terms of the indenture governing the 2014 Notes from incurring additional debt, securing existing or future debt,recapitalizing our debt, or taking a number of other actions that are not limited by the terms of the indenture governing the 2014 Notes that could have theeffect of diminishing our ability to make payments on the 2014 Notes when due. Any failure by us or any of our significant subsidiaries to make any paymentat maturity of indebtedness for borrowed money in excess of $15.0 million or the acceleration of any such indebtedness in excess of $15.0 million would,subject to the terms of the indenture governing the 2014 Notes, constitute a default under the indenture. If the repayment of the related indebtedness were tobe accelerated after any applicable notice or grace periods, we may not have sufficient funds to repay the 2014 Notes when required.In August 2018, we entered into the Revolving Credit Facility with Silicon Valley Bank, which matures on August 2, 2020. Amounts drawn under theRevolving Credit Facility will be used for working capital and general corporate purposes. While we currently have no outstanding debt under the RevolvingCredit Facility, we may incur up to $15.0 million of secured debt pursuant to the Revolving Credit Facility. See Note 6 to the Consolidated FinancialStatements included in this Form 10-K for more information about the Revolving Credit Facility.We may not have the ability to raise the funds necessary to repurchase the 2014 Notes upon specified dates or upon a fundamental change, and ourfuture debt may contain limitations on our ability to repurchase the 2014 Notes.Holders of the 2014 Notes have the right to require us to repurchase all or a portion of their 2014 Notes on certain dates or upon the occurrence of afundamental change at a repurchase price equal to, for the 2014 Notes, 100% of the principal amount of the 2014 Notes to be repurchased plus accrued andunpaid interest, if any. We may not have enough available cash or be able to obtain financing at the time we are required to make repurchases of 2014 Notessurrendered therefor.In addition, our ability to repurchase the 2014 Notes may be limited by law, regulatory authority, or agreements governing our future indebtedness. Ourfailure to repurchase the 2014 Notes at a time when the repurchase is required by the indenture would constitute a default under the indenture. A defaultunder the indenture or the fundamental change itself could also lead to a default under agreements governing our future indebtedness. If the repayment of therelated indebtedness were to be accelerated after any applicable notice or grace periods, we may not have sufficient funds to repay the indebtedness andrepurchase the 2014 Notes when required.Holders of 2014 Notes are not entitled to any rights with respect to our common stock, but they are subject to all changes made with respect to them tothe extent our conversion obligation includes shares of our common stock.Holders of 2014 Notes are not entitled to any rights with respect to our common stock (including, without limitation, voting rights and rights to receiveany dividends or other distributions on our common stock) prior to the conversion date with respect to any 2014 Notes they surrender for conversion, butthey are subject to all changes affecting our common stock. For example, if an amendment is proposed to our certificate of incorporation or bylaws requiringstockholder approval and the record date for determining the stockholders of record entitled to vote on the amendment occurs prior to the conversion datewith respect to any 2014 Notes surrendered for conversion, then the holder surrendering such 2014 Notes will not be entitled to vote on the amendment,although such holder will nevertheless be subject to any changes affecting our common stock.We have made only limited covenants in the indenture governing the 2014 Notes, and these limited covenants may not protect a noteholder'sinvestment.The indenture governing the 2014 Notes does not:•require us to maintain any financial ratios or specific levels of net worth, revenues, income, cash flows, or liquidity and, accordingly, does notprotect holders of the 2014 Notes in the event that we experience adverse changes in our financial condition or results of operations;•limit our subsidiaries’ ability to guarantee or incur indebtedness that would rank structurally senior to the 2014 Notes;•limit our ability to incur additional indebtedness, including secured indebtedness;•restrict our subsidiaries’ ability to issue securities that would be senior to our equity interests in our subsidiaries and therefore would be structurallysenior to the 2014 Notes;36•restrict our ability to repurchase our securities;•restrict our ability to pledge our assets or those of our subsidiaries; or•restrict our ability to make investments or pay dividends or make other payments in respect of our common stock or our other indebtedness.Furthermore, the indenture governing the 2014 Notes contains only limited protections in the event of a change of control. We could engage in manytypes of transactions, such as acquisitions, refinancings, or certain recapitalizations, that could substantially affect our capital structure and the value of the2014 Notes and our common stock but may not constitute a “fundamental change” that permits holders to require us to repurchase their 2014 Notes or a“make-whole fundamental change” that permits holders to convert their 2014 Notes at an increased conversion rate. For these reasons, the limited covenantsin the indenture governing the 2014 Notes may not protect a noteholder's investment in the 2014 Notes.The increase in the conversion rate for 2014 Notes converted in connection with a make-whole fundamental change or provisional redemption may notadequately compensate noteholders for any lost value of the 2014 Notes as a result of such transaction or redemption.If (i) a make-whole fundamental change occurs prior to February 6, 2021, or (ii) upon our issuance of a notice of provisional redemption, under certaincircumstances, we will increase the conversion rate by a number of additional shares of our common stock for the 2014 Notes converted in connection withsuch events. The increase in the conversion rate for the 2014 Notes converted in connection with such events may not adequately compensate noteholders forany lost value of the 2014 Notes as a result of such transaction or redemption. In addition, if the price of our common stock in the transaction is greater than$180.00 per share or less than $39.96 per share (in each case, subject to adjustment), no additional shares will be added to the conversion rate for the 2014Notes. Moreover, in no event will the conversion rate per $1,000 principal amount of 2014 Notes as a result of this adjustment exceed 25.0250 shares ofcommon stock, subject to adjustment.Our obligation to increase the conversion rate for 2014 Notes converted in connection with such events could be considered a penalty, in which casethe enforceability thereof would be subject to general principles of reasonableness and equitable remedies.The conversion rate of the 2014 Notes may not be adjusted for all dilutive events.The conversion rate of the 2014 Notes is subject to adjustment for certain events, including, but not limited to, the issuance of certain stock dividendson our common stock, the issuance of certain rights or warrants, subdivisions, combinations, distributions of capital stock, indebtedness, or assets, cashdividends and certain issuer tender or exchange offers. However, the conversion rate will not be adjusted for other events, such as a third-party tender orexchange offer or an issuance of common stock for cash, that may adversely affect the trading price of the 2014 Notes or our common stock. An event thatadversely affects the value of the 2014 Notes may occur, and that event may not result in an adjustment to the conversion rate.Some significant restructuring transactions may not constitute a fundamental change, in which case we would not be obligated to offer to repurchase the2014 Notes.Upon the occurrence of a fundamental change, a holder of 2014 Notes has the right to require us to repurchase the 2014 Notes. However, thefundamental change provisions will not afford protection to holders of 2014 Notes in the event of other transactions that could adversely affect the 2014Notes. For example, transactions such as leveraged recapitalizations, refinancings, restructurings, or acquisitions initiated by us may not constitute afundamental change requiring us to repurchase the 2014 Notes. In the event of any such transaction, the holders would not have the right to require us torepurchase the 2014 Notes, even though each of these transactions could increase the amount of our indebtedness, or otherwise adversely affect our capitalstructure or any credit ratings, thereby adversely affecting the holders of 2014 Notes.In addition, absent the occurrence of a fundamental change or a make-whole fundamental change as described under changes in the composition of ourboard of directors will not provide holders with the right to require us to repurchase the 2014 Notes or to an increase in the conversion rate upon conversion.We cannot assure noteholders that an active trading market will develop or be maintained for the 2014 Notes.We do not intend to apply to list our outstanding 2014 Notes on any securities exchange or to arrange for quotation on any automated dealer quotationsystem. In addition, the liquidity of the trading market in the 2014 Notes and the market price quoted for the 2014 Notes may be adversely affected bychanges in the overall market for this type of security and by changes37in our financial performance or prospects or in the prospects for companies in our industry generally. As a result, we cannot assure noteholders that an activetrading market will develop or be maintained for the 2014 Notes. If an active trading market does not develop or is not maintained, the market price andliquidity of the 2014 Notes may be adversely affected. In that case, noteholders may not be able to sell the 2014 Notes at a particular time or at a favorableprice.Any adverse rating of the 2014 Notes may cause their trading price to fall.We do not intend to seek a rating on the 2014 Notes. However, if a rating service were to rate the 2014 Notes and if such rating service were to lower itsrating on the 2014 Notes below the rating initially assigned to the 2014 Notes or otherwise announces its intention to put the 2014 Notes on credit watch, thetrading price of the 2014 Notes could decline.Holders of 2014 Notes may be subject to tax if we make or fail to make certain adjustments to the conversion rate of the 2014 Notes even though they donot receive a corresponding cash distribution.The conversion rate of the 2014 Notes is subject to adjustment in certain circumstances, including the payment of cash dividends. If the conversion rateis adjusted as a result of a distribution that is taxable to our common stockholders, such as a cash dividend, a noteholder may be deemed to have received adividend subject to U.S. federal income tax without the receipt of any cash. In addition, a failure to adjust (or to adjust adequately) the conversion rate afteran event that increases a noteholder's proportionate interest in us could be treated as a deemed taxable dividend to you. If a make-whole fundamental changeoccurs prior to February 6, 2021 or upon our issuance of a notice of provisional redemption, under some circumstances, we will increase the conversion ratefor the 2014 Notes converted in connection with the make-whole fundamental change or provisional redemption. Such increase may also be treated as adistribution subject to U.S. federal income tax as a dividend. For a non-U.S. holder, any deemed dividend would be subject to U.S. federal withholding tax ata 30% rate, or such lower rate as may be specified by an applicable treaty, which may be set off against subsequent payments on the 2014 Notes.Any conversions of the 2014 Notes will dilute the ownership interest of our existing stockholders, including holders who had previously converted theirnotes.Any conversion of some or all of the 2014 Notes will dilute the ownership interests of our existing stockholders. The initial conversion price under the2014 Notes is approximately $55.94. As a result, each of the outstanding 2014 Notes is initially convertible into 17.8750 shares of our common stock per$1,000 principal amount. Issuances of shares of common stock upon conversion of our 2014 Notes could depress the market price of our common stock andimpair our ability to raise capital through the sale of additional equity securities. In addition, the existence of the 2014 Notes may encourage short selling bymarket participants because the conversion of the 2014 Notes could depress the price of our common stock.ITEM 1B. UNRESOLVED STAFF COMMENTSNone. ITEM 2. PROPERTIESWe lease approximately 74,100 square feet of office and laboratory space at our headquarters in South San Francisco, California under a lease thatexpires in April 2020. Additionally, we lease office, laboratory and manufacturing space in Singapore of approximately 50,000 square feet and in Ontario,Canada of approximately 44,500 square feet under leases that expire in June 2022 and March 2026, respectively. As of December 31, 2018, we also leasedoffice space in Japan, China, and France, with various expiration dates through February 2026. In addition, we believe that our properties are in goodcondition and are adequate and suitable for their purposes.ITEM 3. LEGAL PROCEEDINGSIn the normal course of business, we are from time to time involved in legal proceedings or potential legal proceedings, including matters involvingemployment, intellectual property, or others. Although the results of litigation and claims cannot be predicted with certainty, we currently believe that thefinal outcome of any currently pending matters would not have a material adverse effect on our business, operating results, financial condition, or cash flows.Regardless of the outcome, litigation can have an adverse impact on us because of defense and settlement costs, diversion of management resources, andother factors.ITEM 4. MINE SAFETY DISCLOSURESNot applicable.38PART IIITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITYSECURITIESMarket for Our Common Stock; DividendsOur common stock began trading on the Nasdaq Global Select Market under the symbol “FLDM” on February 10, 2011.We had 86 stockholders of record as of March 13, 2019; however, because many of our outstanding shares are held by brokers or other institutions onbehalf of stockholders, we are unable to estimate the total number of beneficial owners represented by the holders of record.We have never declared or paid cash dividends on our common stock and do not expect to pay dividends on our common stock for the foreseeablefuture. Instead, we anticipate that all of our earnings in the foreseeable future will be used for the operation and growth of our business.Stock Performance GraphThe following performance graph shall not be deemed “soliciting material” or to be “filed” with the Securities and Exchange Commission for purposesof Section 18 of the Securities Exchange Act of 1934, as amended, or the Exchange Act, or otherwise subject to the liabilities under that Section, and shallnot be deemed to be incorporated by reference into any filing of Fluidigm Corporation under the Securities Act or the Exchange Act.The following graph compares, from December 31, 2013 through December 31, 2018, the cumulative total return for our common stock, the NasdaqComposite Total Return Index, and the Nasdaq US Benchmark Medical Equipment Index, assuming in each case an initial investment of $100 andreinvestment of all dividends. Such returns are based on historical results and are not intended to suggest future performance.39Sales of Unregistered SecuritiesNone.Issuer Purchases of Equity SecuritiesWe did not repurchase any shares of our common stock during the year ended December 31, 2018.ITEM 6. SELECTED FINANCIAL DATAThe following selected financial data should be read in conjunction with the consolidated financial statements and related notes thereto appearingelsewhere in this Form 10-K. We have derived the consolidated statement of operations data for the years ended December 31, 2018, 2017, and 2016, andconsolidated balance sheet data as of December 31, 2018, and December 31, 2017 from audited consolidated financial statements included elsewhere in thisForm 10-K. The consolidated statement of operations data for the years ended December 31, 2015, and 2014, and the consolidated balance sheet data as ofDecember 31, 2016, December 31, 2015, and December 31, 2014 were derived from audited consolidated financial statements that are not included in thisForm 10-K. 2018 2017 2016 2015 2014 (in thousands, except per share amounts)Consolidated Statement of Operations Data: Total revenue $112,964 $101,937 $104,446 $114,712 $116,456 Loss from operations (48,164) (58,360) (73,190) (50,155) (51,836) Net loss (59,013) (60,535) (75,985) (53,315) (52,830) Net loss per share, basic and diluted (1.49) (1.84) (2.62) (1.86) (1.90) 2018 2017 2016 2015 2014 (in thousands)Consolidated Balance Sheet Data: Cash, cash equivalents, and short and long-term investments $95,401 $63,136 $59,430 $101,465 $142,800 Working capital (1) 100,988 71,565 76,334 123,433 133,440 Total assets (2) 303,647 287,351 306,395 370,050 406,506 Total long-term debt (2) 172,058 195,238 194,951 194,673 194,402 Total stockholders’ equity 72,116 30,935 53,233 114,901 150,419 (1) Working capital excludes deferred revenue.(2) $1.0 million and $1.1 million of debt issuance costs for Convertible notes were previously included in Total assets reclassified to Total long-term debt asa deduction in December 31, 2015 and December 31, 2014, respectively.40ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONSThe following discussion and analysis should be read together with our consolidated financial statements and the notes to those statements includedelsewhere in this Form 10-K. This discussion contains forward-looking statements based on our current expectations, assumptions, estimates andprojections about Fluidigm and our industry. These forward-looking statements involve risks and uncertainties. Our actual results could differ materiallyfrom those indicated in these forward-looking statements as a result of certain factors, as more fully described in “Risk factors” in Item 1A of this Form 10-K, in this Item 7, and elsewhere in this Form 10-K. Except as may be required by law, we undertake no obligation to update publicly any forward-lookingstatements for any reason, even if new information becomes available or other events occur in the future.OverviewFluidigm is a global company that improves life through comprehensive health insight. Our innovative technologies and multi-omic tools are used byresearchers to reveal meaningful insights in health and disease, identify biomarkers to inform decisions and accelerate the development of more effectivetherapies. We create, manufacture, and market innovative technologies and life science tools, including preparatory and analytical instruments for MassCytometry, PCR, Library Prep, Single Cell Genomics, and consumables, including IFCs, assays, and reagents.Our focus is on the most pressing needs in translational and clinical research, including cancer, immunology and immunotherapy. We use proprietaryCyTOF® and microfluidics technologies to develop innovative end-to-end solutions that have the flexibility required to meet the needs of translationalresearch and the robustness to support high-impact clinical research studies. We sell our products to leading academic, government, pharmaceutical,biotechnology and plant and animal research laboratories worldwide.We distribute our systems through our direct sales force and support organizations located in North America, Europe, and Asia-Pacific, and throughdistributors or sales agents in several European, Latin American, Middle Eastern, and Asia-Pacific countries. Our manufacturing operations are located inSingapore and Canada. Our facility in Singapore manufactures our genomics instruments, which are assembled by our contract manufacturer located withinour in Singapore facility. All of our IFCs for commercial sale and some IFCs for our research and development purposes are also fabricated at our Singaporefacility. Our mass cytometry instruments for commercial sale, as well as for internal research and development purposes, are manufactured at our facility inCanada. We also manufacture assays and reagents at our facilities in the United States. We also manufacture assays and reagents at our facilities in the UnitedStates. As part of our on-going efforts related to operational excellence and improving efficiencies, we are consolidating our North American productionactivities into our Canadian facility.Our total revenue was $113.0 million in 2018, $101.9 million in 2017, and $104.4 million in 2016. We have incurred significant net losses since ourinception in 1999 and, as of December 31, 2018, our accumulated deficit was $558.9 million.At the end of 2016, we began reallocating our resources based on revenue contribution and growth expectations across our target markets, including areorganization of our sales team and commercial leadership. We implemented certain operational efficiencies and cost-savings initiatives beginning in thefirst quarter of 2017 intended to align our resources with our product strategy, reduce our operating expenses, and manage our cash flows. In 2017 and 2018,we have grown our revenues, increased gross margins, reduced operating expenses, streamlined our manufacturing operations, and rationalized our headcountand facilities. These activities have resulted in lower net losses, improving from $76.0 million in 2016 to $59.0 million in 2018. We have also strengthenedour balance sheet through the issuance of common stock and refinancing our convertible debt. In August 2017, we sold 9.1 million shares of common stockfor aggregate net proceeds of approximately $28.8 million; in December 2018, we sold approximately 9.4 million shares of common stock for aggregate netproceeds of $59.1 million. In March 2018, we refinanced $150 million of our convertible debt which effectively extended the maturity of the debt whileproviding us with additional financing flexibility. These transactions are described in Note 6 and Note 8 of our audited 2018 consolidated financialstatements.Recent DevelopmentsFrom January 9, 2019 through February 27, 2019, we received notices from holders of the 2018 Notes electing to voluntarily convert approximately$138.1 million in aggregate principal amount pursuant to the terms of the Second Supplemental Indenture dated March 6, 2018, between us and U.S. BankNational Association (Trustee) to the Indenture dated as of February 14, 2014, between us and the Trustee. As a result of such voluntary conversions, we haveelected to fully satisfy our conversion obligations by delivering approximately 17.9 million shares of our common stock to such holders and have retiredapproximately $138.1 million of the 2018 Notes. On February 27, 2019, we notified the Trustee of our intention to41exercise our Issuer’s Conversion Option pursuant to the terms of the Second Supplemental Indenture with respect to the remaining approximately $11.9million in aggregate principal amount of 2018 Notes. These bonds were converted into approximately 1.5 million shares of our common stock and the bondsretired in March 2019.In early March 2019, we experienced a ransomware attack that infiltrated and encrypted certain of our information technology systems, includingsystems containing critical business data. Immediately following the attack, actions were taken to recover the compromised systems and we believe we wereable to restore their operation without significant loss of business data. Based on the nature of the attack and its impact on our systems, we do not believeconfidential data was lost or disclosed, but we are continuing to monitor the situation. If confidential data is later determined to have been released in thecourse of this event, it is possible that we could be the subject of actions by governmental authorities or claims from persons alleging they suffered damagesfrom such a release. As of the date of this filing, we estimate the costs associated with the intrusion to be approximately $1.5 million and are seeking torecover these costs under an applicable insurance policy. Although we believe we have now contained the disruption, we anticipate additional work andexpense in the future as we continue to respond to the attack and further enhance our security processes and initiatives.Critical Accounting Policies, Significant Judgments and EstimatesOur consolidated financial statements and the related notes included elsewhere in this Form 10-K are prepared in accordance with accountingprinciples generally accepted in the United States. The preparation of these consolidated financial statements requires us to make estimates and assumptionsthat affect the reported amounts of assets, liabilities, revenue, costs, and expenses and related disclosures. We base our estimates on historical experience andon various other assumptions that we believe to be reasonable under the circumstances. Changes in accounting estimates may occur from period to period.Accordingly, actual results could differ significantly from the estimates made by our management. We evaluate our estimates and assumptions on an ongoingbasis. To the extent that there are material differences between these estimates and actual results, our future financial statement presentation, financialcondition, results of operations, and cash flows will be affected.We believe that the following critical accounting policies involve a greater degree of judgment and complexity than our other accounting policies.Accordingly, these are the policies we believe are the most critical to understanding and evaluating of our audited 2018 consolidated financial statements.Revenue RecognitionWe generate revenue primarily from sales of our products and services. Our product revenue consists of sales of our mass cytometry, high-throughputgenomics and single-cell genomics instruments and consumables, including IFCs, assays, and other reagents. Our service revenue consists of post-warrantyservice contracts, preventive maintenance plans, repairs, installation, training and other specialized product support services. We also receive revenue fromour license agreements with third parties. Revenue is reported net of any sales, use and value-added taxes we collect from customers as required bygovernment authorities.We recognize revenue based on the amount of consideration we expect to receive in exchange for the goods and services we transfer to the customer.Our commercial arrangements typically include multiple distinct products and services, and we allocate revenue to these performance obligations based ontheir relative standalone selling prices. Standalone selling prices (SSPs) are generally determined using observable data from recent transactions. In caseswhere sufficient data is not available, we estimate a product’s SSP using a cost plus a margin approach or by applying a discount to the product’s list price.Product RevenueWe recognize product revenue at the point in time when control of the goods passes to the customer and we have an enforceable right to payment. Thisgenerally occurs either when the product is shipped from one of our facilities or when it arrives at the customer’s facility, based on the contractual terms.Customers generally do not have a unilateral right to return products after delivery. Invoices are generally issued at shipment and become due in 30 to 60days.Service RevenueWe recognize revenue from repairs, installation, training and other specialized product support services at the point in time the work is completed.Installation and training services are generally billed in advance of service. Repairs and other services are generally billed at the point the work is completed.42Revenue associated with instrument service contracts is recognized on a straight-line basis over the life of the agreement, which is generally one to threeyears. We believe this approach is appropriate for service contracts because we provide services on demand throughout the term of the agreement. Invoicesare generally issued in advance of service on a monthly, quarterly, annual or multi-year basis. Payments made in advance of service are reported on ourconsolidated balance sheet as deferred revenue.Contract CostsIncremental sales commission costs incurred to obtain instrument service contracts are capitalized and amortized to selling, general and administrativeexpense over the life of the contract, which is generally one to three years. As a practical expedient, we expense sales commissions associated with productsupport services that are delivered in less than one year as they are incurred. Sales commissions associated with the sale of products are expensed as they areincurred.Product WarrantiesWe generally provide a one-year warranty on our instruments. We accrue for estimated warranty obligations at the time of product shipment. Weperiodically review our warranty liability and record adjustments based on the terms of warranties provided to customers, and historical and anticipatedwarranty claim experience. This expense is recorded as a component of cost of product revenue in the consolidated statements of operations.Significant JudgmentsApplying the revenue recognition practices discussed above often requires significant judgment. Judgment is required when identifying performanceobligations, estimating SSP and allocating purchase consideration in multi-element arrangements and estimating the future amount of our warrantyobligations. Significant judgment is also required when interpreting commercial terms and determining when control of goods and services passes to thecustomer. Any material changes created by errors in judgment could have a material effect on our operating results and overall financial condition.Goodwill, Intangible Assets and Other Long-Lived AssetsGoodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Our intangible assets include developedtechnology, patents and licenses. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets’respective estimated useful lives.Goodwill and intangible assets with indefinite lives are not subject to amortization, but are tested for impairment on an annual basis during the fourthquarter or whenever events or changes in circumstances indicate the carrying amount of these assets may not be recoverable. We first conduct an assessmentof qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than its carrying amount. If we determinethat it is more likely than not that the fair value of our reporting unit is less than its carrying amount, we then conduct a two-step test for impairment ofgoodwill. In the first step, we compare the fair value of our reporting unit to its carrying value. If the fair value of our reporting unit exceeds its carrying value,goodwill is not considered impaired and no further analysis is required. If the carrying value of the reporting unit exceeds its fair value, then the second stepof the impairment test must be performed in order to determine the implied fair value of the goodwill. If the carrying value of the goodwill exceeds its impliedfair value, then an impairment loss equal to the difference would be recorded.We evaluate our long-lived assets, including finite-lived intangibles, for indicators of possible impairment when events or changes in circumstancesindicate the carrying amount of an asset may not be recoverable. If any indicators of impairment exist, we assess the recoverability of the affected long-livedassets by determining whether the carrying value of the asset can be recovered through undiscounted future operating cash flows. If impairment is indicated,we estimate the asset’s fair value using future discounted cash flows associated with the use of the asset and adjust the carrying value of the asset accordingly.We did not recognize any impairment of long-lived assets for any of the periods presented herein.Convertible NotesIn February 2014, we closed an underwritten public offering $201.3 million aggregate principal amount of our 2.75% Senior Convertible Notes due2034 (2014 Notes). In March 2018, we entered into separate privately negotiated transactions with certain holders of our 2014 Notes to exchange $150.0million in aggregate principal amount of the 2014 Notes for our new 2.75% Exchange Convertible Senior Notes due 2034 (2018 Notes). Following theexchange, approximately $51.3 million in43aggregate principal amount of the 2014 Notes remained outstanding in addition to $150.0 million in aggregate principal amount of the 2018 Notes.As the 2018 Notes are convertible, at our election, into cash, shares of our common stock, or a combination of cash and shares of our common stock, weaccounted for the 2018 Notes under the cash conversion guidance in ASC 470, whereby the embedded conversion option in the 2018 Notes was separatedand accounted for in equity. The embedded conversion option value was calculated as the difference between (i) the total fair value of the 2018 Notes and (ii)the fair value of a similar debt instrument excluding the embedded conversion option. We determined an embedded conversion option value of $29.3million, which was recorded in additional paid-in-capital and reduced the carrying value of the 2018 Notes. The resulting discount on the 2018 Notes will beamortized over the expected term of the 2018 Notes, using the effective interest method through the first note holder put date of February 6, 2023.For both the 2014 Notes and 2018 Notes, offering-related costs, including underwriting costs, were capitalized as debt issuance costs, recorded as anoffset to the carrying value of the related Notes, and are amortized over the expected term of the related Notes using the effective interest method.Stock-Based CompensationOur board of directors sets the terms, conditions, and restrictions related to our Employee Stock Purchase Plan (ESPP) and the grant of stock options,Restricted Share Units (RSUs) and performance-based awards under our various stock-based plans. Our board of directors determines the number of awards togrant and sets the vesting criteria. For performance-based share awards, our board of directors sets the performance objectives and other vesting provisions indetermining the number of shares or value of performance units and performance shares that will be paid out. Such payout will be a function of the extent towhich performance objectives or other vesting provisions have been achieved.We recognize compensation costs for all stock-based awards, including stock options, RSUs, and stock purchased under our ESPP, based on the grantdate fair value of the award. We recognize stock-based compensation expense on a straight-line basis over the requisite service periods for non-performance-based awards. For performance-based stock awards, stock-based compensation expense is recognized over the requisite service period when the achievementof each individual performance goal becomes probable.Stock-based compensation cost for restricted stock units granted to employees is measured based on the closing fair market value of our common stockon the date of grant. The fair value of options and stock purchases under ESPP on the grant date is estimated using the Black-Scholes option-pricing model,which requires the use of certain subjective assumptions, including expected term, volatility, risk-free interest rate and the fair value of our common stock.These assumptions generally require significant judgment. We determine the expected volatility based on our historical stock price volatility generallycommensurate with the estimated expected term of the stock awards. The expected term of an award is based on historical forfeiture experience, exerciseactivity, and the terms and conditions of the stock awards. The risk-free interest rate is based on the U.S. Treasury yield in effect at the time of grant for zerocoupon U.S. Treasury notes with maturities approximately equal to each grant’s expected term. We account for forfeitures as they occur.Income TaxesWe use the asset and liability method to account for income taxes. Deferred tax assets and liabilities are recognized for the future tax consequencesattributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assetsand liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to berecovered or settled. Significant management judgment is required in determining our provision for income taxes, our deferred tax assets and liabilities, andany valuation allowance recorded against our deferred tax assets. Our provision for income taxes generally consists of tax expense/benefit related to currentperiod earnings/losses.As part of the process of preparing our consolidated financial statements, we continuously monitor the circumstances impacting the expectedrealization of our deferred tax assets for each jurisdiction. We consider all available evidence, including historical operating results in each jurisdiction,expectations and risks associated with estimates of future taxable income, and ongoing prudent and feasible tax planning strategies in assessing the need fora valuation allowance. To the extent a deferred tax asset cannot be recognized, a valuation allowance is established to reduce our deferred tax assets to theamount that is more likely than not to be realized. These deferred tax assets primarily consist of net operating loss carryforwards, research and developmenttax credits, and stock-based compensation. We intend to maintain such valuation allowance until sufficient evidence exists to support its reduction. Ourdeferred tax liabilities primarily consist of book and tax basis differences in fixed44assets and acquired identifiable intangible assets. We make estimates and judgments about our future taxable income that are based on assumptions that areconsistent with our plans and estimates. Should the actual amounts differ from our estimates, the amount of our valuation allowance could be materiallyimpacted. Changes in these estimates may result in significant increases or decreases to our tax provision in a period in which such estimates are changed,which in turn would affect net income or loss.We recognize the financial statement effects of a tax position when it is more likely than not, based on the technical merits, that the position will besustained upon examination. Any interest and penalties related to uncertain tax positions are reflected in the income tax provision.The Tax Cuts and Jobs Act (the Tax Act) was enacted in December 2017. The Tax Act introduced a broad range of tax reform measures that significantlychanged the federal income tax laws. At December 31, 2017, we recorded the provisional income tax effects of the Tax Act in accordance with ASU No. 2018-05, Income Taxes (Topic 740). Due to our having recorded a full valuation allowance against its U.S. federal and state deferred tax assets, there was no netimpact on our tax provision as a result of the remeasurement of U.S. deferred taxes using the relevant tax rate at which we expect them to reverse. The one-time transition tax on post-1986 foreign unremitted earnings did not have a material impact to our effective tax rate as a result of our generating net foreigndeficit earnings. In accordance with Staff Accounting Bulletin (SAB No. 118, we completed the accounting related to tax reform in the fourth quarter of 2018and no material adjustments to the provisional tax expense were required. We continue to monitor supplemental legislation and technical interpretations ofthe tax law that may cause the final impact from the Tax Act to differ from the amounts previously recorded.At December 31, 2017, we changed our permanent reinvestment assertion and will not permanently reinvest our foreign earnings outside the UnitedStates. The cash generated from some of our foreign subsidiaries may be used domestically to fund operations. Any domestic, foreign withholding tax andstate taxes that may be due upon future repatriation of earnings is not expected to be significant.Inventory ValuationInventories are stated at the lower of cost (on a first-in, first-out basis) or net realizable value. Inventory costs include direct materials, direct labor, andnormal manufacturing overhead. Finished goods that are used for research and development are expensed as consumed or depreciated over their period ofuse. We regularly review inventory for excess and obsolete products and components. Provisions for slow-moving, excess, and obsolete inventories arerecorded when required to reduce inventory values to their estimated net realizable values based on product life cycle, development plans, productexpiration, and quality issues.Recent Accounting Changes and Accounting PronouncementsAdoption of New Accounting GuidanceIn May 2014, the FASB issued ASU 2014-09 Revenue from Contracts with Customers (Topic 606). Topic 606 and its related amendments supersedeRevenue Recognition (Topic 605), issued in June 2010, and provide principles for recognizing revenue for goods and services in a manner consistent withthe transfer of control of those goods and services to the customer.We adopted Topic 606 on January 1, 2018, using the modified retrospective method applied to those contracts with unrecognized revenue on theadoption date. We recognized the effect of applying the new revenue standard by recording a cumulative catch-up adjustment that reduced the accumulateddeficit component of stockholders’ equity by $0.4 million and increased current assets by $0.2 million and non-current assets by $0.2 million. Theadjustment capitalized certain sales commission costs that were incurred to obtain instrument service contracts. Under Topic 605, we accounted for theseincremental contract acquisition costs by recognizing them as expense at the point the contract was awarded. Under Topic 606, the costs are capitalized andamortized to expense over the life of the contract, which is generally one to three years. The comparative information for periods prior to January 1, 2018, hasnot been restated and continues to be reported in accordance with Topic 605.The following table summarizes the cumulative effect of adopting Topic 606 on amounts previously reported in our consolidated balance sheet atDecember 31, 2017 (in thousands):45 Balance at December31, 2017 Topic 606 TransitionAdjustments Balance at January1, 2018Prepaid expenses and other current assets $1,528 $153 $1,681Total current assets $94,801 $153 $94,954Other non-current assets $7,541 $205 $7,746 Total assets $287,351 $358 $287,709Accumulated deficit $(500,196) $358 $(499,838)Total stockholders' equity $30,935 $358 $31,293 Total liabilities and stockholders' equity $287,351 $358 $287,709The following table summarizes the impacts on our consolidated statement of operations of adopting Topic 606 compared to Topic 605 for the twelvemonths ended December 31, 2018 (in thousands): As Reported Balance WithoutAdoption ofTopic 606 Effect of Change Twelve Months Ended December 31, 2018Selling, general and administrative $79,783 $79,859 $(76)Total costs and expenses $161,128 $161,204 $(76)Loss from operations $(48,164) $(48,240) $76Loss before income taxes $(61,420) $(61,496) $76 Net loss $(59,013) $(59,089) $76The following table summarizes the impacts on our consolidated balance sheet of adopting Topic 606 compared to Topic 605 at December 31, 2018 (inthousands): As Reported Balance WithoutAdoption of Topic 606 Effect of Change December 31, 2018 Prepaid expenses and other current assets $2,051 $1,884 $167Total current assets $127,106 $126,939 $167Other non-current assets $6,208 $5,941 $267 Total assets $303,647 $303,213 $434Stockholders' equity $72,116 $71,682 $434 Total liabilities and stockholders' equity $303,647 $303,213 $434In March 2018, the FASB issued ASU No. 2018-05, Income Taxes (Topic 740): Amendments to SEC Paragraphs Pursuant to SEC Staff AccountingBulletin No. 118. This ASU allows SEC reporting companies to record provisional amounts in earnings for the year ended December 31, 2017, due to thecomplexities involved in accounting for the enactment of the Tax Act. We recognized the estimated income tax effects of the Tax Act in its 2017Consolidated Financial Statements in accordance with SEC Staff Accounting Bulletin No. 118. In accordance with SAB No. 118, we completed theaccounting related to tax reform in the fourth quarter of 2018 and no material adjustments to the provisional tax expense were required. Refer to Note 10 ofthe consolidated financial statements in the Form 10-K for the fiscal year ended December 31, 2018 for further information regarding the provisional amountsrecorded by the Company.In August 2016, the FASB issued ASU 2016-15 Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments. TheASU addresses eight specific cash flow issues and their presentation within the statement of cash flows. We adopted this ASU in the first quarter of 2018. Theadoption of this ASU did not have a material impact on our consolidated financial statements.46In November 2016, the FASB issued ASU 2016-18 Statement of Cash Flows (Topic 230): Restricted Cash, a consensus of the FASB’s Emerging IssuesTask Force, which amended the presentation of restricted cash within the statement of cash flows. The new guidance requires restricted cash be includedwithin cash and cash equivalents on the statement of cash flows. We adopted this ASU in the first quarter of 2018. The adoption of this ASU did not have amaterial impact on our consolidated financial statements.Recent Accounting PronouncementsIn August 2018, the FASB issued ASU 2018-15 Intangibles—Goodwill and Other—Internal-Use Software (Subtopic 350-40) which establishes newguidance on the accounting for costs incurred to implement a cloud computing arrangement that is considered a service arrangement. The new guidancerequires the capitalization of such costs, aligning it with the accounting for costs associated with developing or obtaining internal-use software. The newguidance is effective for fiscal years beginning after December 15, 2019. We are currently evaluating the impact of adoption on its consolidated financialstatements.In February 2016, the FASB established Topic 842, Leases, by issuing Accounting Standards Update (ASU) No. 2016-02, which requires lessees torecognize leases on-balance sheet and disclose key information about leasing arrangements. Topic 842 was subsequently amended by ASU No. 2018-01,Land Easement Practical Expedient for Transition to Topic 842; ASU No. 2018-10, Codification Improvements to Topic 842, Leases; and ASU No. 2018-11,Targeted Improvements. The new standard establishes a right-of-use (ROU) model that requires a lessee to recognize a ROU asset and lease liability on thebalance sheet for all leases with a term longer than 12 months. Leases will be classified as finance or operating; the classification will impact the expenserecognition in the income statement.A Modified Retrospective Transition approach is required, applying the new standard to all leases existing at the date of initial application. An entitymay choose to use either (1) its effective date or (2) the beginning of the earliest comparative period presented in the financial statements as its date of initialapplication. We expect to adopt the new standard on January 1, 2019 and use the effective date as our date of initial application. Consequently, financialinformation will not be updated, and the disclosures required under the new standard will not be provided for dates and periods before January 1, 2019. Fordates and periods prior to January 1, 2019, the original disclosures under ASC 840 will be disclosed.The new standard provides several optional practical expedients upon transition. We expect to elect the ‘package of practical expedients’, whichpermits us not to reassess under the new standard our prior conclusions about lease identification, lease classification, and initial direct costs. We do notexpect to elect the use-of-hindsight or the practical expedient pertaining to land easements; the latter not being applicable to us.We expect that this standard will have a material effect on our financial statements. While we continue to assess all the effects of adoption, we currentlybelieve the most significant effects relate to the recognition of new ROU assets and lease liabilities on our balance sheet for our building, vehicle andequipment leases. On adoption, we currently expect to recognize $8.0 million to $11.0 million of additional operating liabilities, based on the present valueof the remaining fixed rental payments under current leasing standards for existing operating leases, with corresponding ROU assets of approximately $6.0million to $9.0 million. The difference between the initial lease liability and right of use asset is attributable to deferred rent. We do not expect any impact onretained earnings from the adoption of ASC 842.The new standard also provides certain accounting elections for an entity’s ongoing accounting. We currently expect to elect the short-term leaserecognition exemption for all leases that qualify. This means, for those leases that qualify, we will not recognize ROU assets or lease liabilities. We alsocurrently expect to elect to not separate lease and nonlease components for our building leases and to take a portfolio approach for our vehicle leases bycountry.In January 2017, the FASB issued ASU 2017-04, Intangibles - Goodwill and Other (Topic 350): Simplifying the Test for Goodwill Impairment. The ASUeliminates the requirement for an entity to calculate the implied fair value of goodwill to measure a goodwill impairment charge. Instead, an entity performsits annual, or interim, goodwill impairment testing by comparing the fair value of a reporting unit with its carrying amount and recording an impairmentcharge for the amount by which the carrying amount exceeds the fair value. The ASU will be effective for annual and interim goodwill impairment testingperformed for our fiscal year beginning January 1, 2020, with early adoption permitted. We are currently evaluating the effect that the updated standard willhave on our consolidated financial statements.47Results of OperationsThe following table presents our historical consolidated statements of operations data for the years ended December 31, 2018, 2017, and 2016, and as apercentage of total revenue for the respective years (in thousands): Year Ended December 31, 2018 2017 2016Revenue: Total revenue $112,964 100 % $101,937 100 % $104,446 100 %Cost of sales: Cost of product revenue 44,861 39 45,039 44 41,110 39Cost of service revenue 6,454 6 4,916 5 4,899 5Total cost of sales 51,315 45 49,955 49 46,009 44Gross profit 61,649 55 % 51,982 51 % 58,437 56 %Operating expenses: Research and development 30,030 27 30,826 30 38,415 37Selling, general and administrative 79,783 71 79,516 78 93,212 89Total operating expenses 109,813 98 110,342 108 131,627 126Loss from operations (48,164) (43) (58,360) (57) (73,190) (70)Interest expense (13,893) (12) (5,824) (6) (5,820) (6)Other income (expense), net 637 1 385 1 (1,167) (1)Loss before income taxes (61,420) (54) (63,799) (62) (80,177) (77)Benefit from income taxes 2,407 2 3,264 3 4,192 4Net loss $(59,013) (52)% $(60,535) (59)% $(75,985) (73)%RevenueWe generate revenue primarily from sales of our products and services, and license agreements. Our product revenue consists of sales of instruments andconsumables. Consumable revenues are largely driven by the size of our installed base of instruments and the annual level of pull-through per instrument.Service revenue is linked to our sales of instruments as our service revenue consists of post-warranty service contracts, preventive maintenance plans,instrument parts, installation and training. Our license revenue is generated primarily in the United States and relates to licensing our technology to third-parties.We sell our instruments to leading academic research institutions, translational research and medicine centers, cancer centers, clinical researchlaboratories, and biopharmaceutical, biotechnology, contract research organizations, and Ag-Bio companies. No single customer represented more than 10%of our total revenue for 2018, 2017, or 2016. Revenue from our five largest customers was 17%, 14% and 15% of total revenue in 2018, 2017, and 2016,respectively.48The following table presents our revenue by source for the years ended December 31, 2018, 2017, and 2016, and as a percentage of total revenue for therespective years (in thousands): Year Ended December 31, Change 2018 2017 2016 2018 2017Revenue: Instruments $45,491 40% $42,505 42% $46,834 45% 7 % (9)%Consumables 48,159 43 41,894 41 42,169 40 15 % (1)%Product revenue 93,650 83% 84,399 83% 89,003 85% 11 % (5)%Service revenue 19,314 17 17,348 17 15,205 15 11 % 14 %License revenue — — 190 — 238 — (100)% (20)%Total revenue $112,964 100% $101,937 100% $104,446 100% 11 % (2)% The following table presents our total revenue by geographic area of our customers and as a percentage of total revenue for each year presented (inthousands): Year Ended December 31, Change 2018 2017 2016 2018 2017Americas $51,172 46% $49,290 48% $56,229 54% 4% (12)%EMEA 36,617 32 32,642 32 29,739 28 12% 10 %Asia-Pacific 25,175 22 20,005 20 18,478 18 26% 8 %Total revenue $112,964 100% $101,937 100% $104,446 100% 11% (2)%The Americas revenue includes revenue generated in the United States of $48.1 million, $45.8 million, and $52.6 million for 2018, 2017 and 2016,respectively.Total RevenueTotal revenue increased by $11.0 million or 11%, to $113.0 million for 2018 compared to $101.9 million for 2017, primarily due to increased sales ofour mass cytometry instruments and related service revenues, mass cytometry consumables, and microfluidics consumables. Revenue grew in 2018 comparedto the prior year across all regions for both products and services. The significant growth in the Asia-Pacific region primarily reflects mass cytometryinstrument and consumables growth in Japan and China. Changes in foreign currency exchange rates had a minimal impact on revenue in 2018.Total revenue decreased by $2.5 million, or 2%, to $101.9 million for 2017 compared to $104.4 million for 2016. The revenue decrease waspredominantly in the United States, partially offset by increases in Europe and Asia-Pacific. The decrease in the United States was mainly attributable tolower instrument sales, particularly our single-cell systems, partially offset by an increase in service revenue. The increases in Europe and Asia-Pacific wereprimarily driven by higher mass cytometry product sales, partially offset by a decrease in sales of our single-cell products.Product RevenueProduct revenue increased by $9.3 million, or 11%, to $93.7 million for 2018 from $84.4 million in 2017. Instrument sales increased $3.0 million, or7% in 2018 compared to 2017, due to higher mass cytometry instrument sales in the Americas and Asia-Pacific from higher unit volumes and average sellingprices, partially offset by softer microfluidic instrument sales in both regions. Instrument sales in EMEA declined in 2018 compared to 2017, with softer masscytometry instrument sales partially offset by higher microfluidic instrument sales.Consumables sales increased $6.3 million, or 15% in 2018 compared to 2017, due to unit volume growth in both mass cytometry and microfluidicconsumables, which comprise the bulk of our microfluidics business. Asia-Pacific and EMEA experienced strong growth in both mass cytometry andmicrofluidics consumables year-over-year. Total consumables sales in the Americas were essentially flat in 2018 versus 2017, with growth in mass cytometryoffset by declines in microfluidics.49Product revenue decreased by $4.6 million, or 5%, to $84.4 million for 2017 compared to $89.0 million for 2016. Instrument revenue decreased by $4.3million, or 9%, to $42.5 million for 2017 compared to 2016, predominately due to lower unit sales of our microfluidics instruments and particularly our C1systems, partially offset by higher unit sales of our mass cytometry instruments. Consumables revenue decreased by $0.3 million, or 1%, to $41.9 million for2017 compared to 2016, largely attributable to decreased unit sales of single-cell consumables and lower average selling prices for most consumables,partially offset by increased unit sales of mass cytometry reagents.We expect the average selling prices of our products to fluctuate over time based on market conditions, product mix, and currency fluctuations.Service RevenueService revenue increased by $2.0 million, or 11%, to $19.3 million for 2018 compared to 2017. Service revenue increased by $2.1 million, or 14%, to$17.3 million for 2017 compared to 2016. The increases in both 2018 and 2017 were primarily due to an increase in instruments under post-warranty servicecontracts as a result of growth in mass cytometry instruments. Revenue from post-warranty service contracts generally lags changes our instrument revenue byone year. Cost of Product and Service RevenueCost of product revenue includes manufacturing costs incurred in the production process, including component materials, labor and overhead,installation, packaging, and delivery costs. In addition, cost of product revenue includes amortization of developed technology and intangibles, royalty costsfor licensed technologies included in our products, warranty, provisions for slow-moving and obsolete inventory, and stock-based compensation expense.Cost of service revenue includes direct labor hours, overhead and instrument parts. While margins vary between product and service offerings, in general,instruments have the lowest profit margin, while margins on consumables tend to be higher than instrument margins. Service margins tend to be between theinstrument and consumable margins.The following table presents our cost of product and service revenue, total cost of sales, product and service margin, and gross margin for each yearpresented (in thousands): Year Ended December 31, 2018 2017 2016Cost of product revenue $44,861 $45,039 $41,110Cost of service revenue 6,454 4,916 4,899Total cost of sales $51,315 $49,955 $46,009 Product margin 52.1% 46.6% 53.8%Service margin 66.6% 71.7% 67.8%Gross margin 54.6% 51.0% 55.9%Product margin increased 5.5 percentage points in 2018 compared to 2017. The year-over-year increase in product margin was due to favorablemanufacturing capacity utilization and product mix, coupled with the impact of fixed amortization on a higher revenue base in 2018.Product margin decreased 7.0 percentage points in 2017 compared to 2016, primarily driven by increased microfluidic unit product costs from lowerproduction volumes, higher excess and obsolete inventory expense and, to a lesser extent, lower average selling prices across most of the products, and theimpact of fixed amortization on a lower revenue base in 2017. Favorable product mix partially offsets these negative factors.Service margin decreased 5.1 percentage points during 2018 compared to 2017. Service margin decreased primarily due to product mix, with a greaterpercentage of service revenue coming from servicing mass cytometry products than microfluidics products. Service costs tend to be higher for mass cytometryinstruments compared to microfluidic instruments as the servicing is more labor-intensive.Service margin increased 3.9 percentage points during 2017 compared to 2016, mainly due to lower labor costs driven by product mix.50Operating ExpensesThe following table presents our operating expenses for each year presented (in thousands): Year Ended December 31, 2018 vs. 2017change 2017 vs. 2016change 2018 2017 2016 Research and development $30,030 $30,826 $38,415 (3)% (20)%Selling, general and administrative 79,783 79,516 93,212 — % (15)%Total operating expenses $109,813 $110,342 $131,627 — % (16)%Research and DevelopmentResearch and development expense consists primarily of personnel and independent contractor costs, prototype and material expenses and otherallocated facilities, and information technology expenses. We have made substantial investments in research and development since our inception. Ourresearch and development efforts have focused primarily on enhancing our technologies and supporting development and commercialization of new andexisting products and services.Research and development expense decreased by $0.8 million, or 3%, to $30.0 million for 2018 compared to $30.8 million for 2017, as a result of thelower severance and employee-related expenses.Research and development expense decreased by $7.6 million, or 20%, to $30.8 million for 2017. The decrease in research and development expensefor 2017 was primarily attributable to our cost-savings initiatives, which included headcount and compensation savings of $3.6 million. In addition, productmaterials and supplies costs decreased by $3.1 million mainly due to fewer projects in 2017 driven by our strategic realignment and focus.We believe that our continued investment in research and development is essential to our long-term competitive position and that these expenses mayincrease in future periods.Selling, General and AdministrativeSelling, general and administrative expense consists primarily of personnel costs for our sales, marketing and administrative employees, facilities,depreciation and professional services, such as legal and accounting services.Selling, general and administrative expense increased by $0.3 million, or 0%, to $79.8 million for 2018 compared to $79.5 million for 2017. Theincrease in 2018 was primarily due to higher headcount-related costs.Selling, general and administrative expense decreased by $13.7 million or 15% to $79.5 million for 2017 compared to $93.2 million for 2016. Thisdecrease for 2017 was primarily due to our cost-savings initiatives, which included infrastructure and facilities savings of $3.4 million. In addition, we hadlower net legal expenses of $6.2 million mainly attributable to settlements in 2017 of previously pending litigations, a decrease in outside services of $1.5million, a decrease in travel expenses of $1.2 million and a decrease in recruiting costs of $1.1 million.Interest Expense and Other Income (Expense), NetThe following table presents these items for each year presented (in thousands): Year Ended December 31, 2018 vs. 2017change 2017 vs. 2016change 2018 2017 2016 Interest expense $(13,893) $(5,824) $(5,820) (139)% — %Other income (expense), net 637 385 (1,167) (65)% 133 %Total $(13,256) $(5,439) $(6,987) (144)% 22 %51As noted above in Critical Accounting Policies, in March 2018, we entered into privately negotiated transactions with certain holders of our 2014Notes to exchange $150.0 million in aggregate principal amount of the 2014 Notes for $150.0 million in aggregate principal amount of our new 2.75%Exchange Convertible Senior Notes due 2034. As the 2018 Notes are convertible, at our election, into cash, shares of our common stock, or a combination ofcash and shares of our common stock. we accounted for the 2018 Notes under the cash conversion guidance in ASC 470. Because of this conversion option,along with a redemption premium, the net effective interest rate for the 2018 Notes is higher than the 2014 Notes. The effective interest rate on the 2014Notes and the 2018 Notes is approximately 3.0% and 12.3%, respectively. The majority of the difference in effective interest rates is due to non-cashamortization of debt discounts. With the higher effective interest rate, interest expense increased in 2018 as compared to 2017 and 2016.Other income, net, of $0.6 million for 2018 is primarily attributable to $0.6 million of interest income. Other income, net, of $0.4 million for 2017includes $0.3 million of interest income. Other expense, net, of $1.2 million for 2016 was mainly associated with losses of $1.5 million from revaluation ofcertain foreign currency denominated assets and liabilities, partially offset by $0.3 million of interest income.Benefit from Income TaxesWe recorded a tax benefit of $2.4 million, or an effective tax rate benefit of 3.9%, for the year ended December 31, 2018. The tax benefit wasprincipally due to the amortization of our acquisition-related deferred tax liability, partially offset by net income tax expense from our foreign operations andunrecognized tax benefits.We recorded a tax benefit of $3.3 million, or an effective tax rate benefit of 5.1%, for the year ended December 31, 2017. This tax benefit was primarilyattributable to amortization of our acquisition-related deferred tax liability.We recorded a tax benefit of $4.2 million, or an effective tax rate benefit of 5.2% for the year ended December 31, 2016. The tax benefit was principallydue to the amortization of our acquisition-related deferred tax liability, partially offset by net income tax expense from our foreign operations andunrecognized tax benefits.Liquidity and Capital ResourcesSources of LiquidityAs of December 31, 2018, our principal sources of liquidity consisted of $95.4 million of cash and cash equivalents.The following table presents our cash flow summary for each year presented (in thousands): Year Ended December 31, 2018 2017 2016Cash flow summary: Net cash used in operating activities $(25,201) $(24,098) $(39,138)Net cash provided by investing activities 4,719 17,658 45,102Net cash provided by financing activities 57,660 28,997 116Net increase in cash and cash equivalents 37,345 23,011 5,928Net Cash Used in Operating ActivitiesWe derive cash flows from operations primarily from cash collected from the sale of our products and services, and license agreements. Our cash flowsfrom operating activities are also significantly influenced by our use of cash for operating expenses and working capital to support the business. We havehistorically experienced negative cash flows from operating activities as we have expanded our business and built our infrastructure domestically andinternationally.Net cash used in operating activities in 2018 was $25.2 million and consisted of net loss of $59.0 million less non-cash adjustments of $36.3 million,and a net increase in assets and liabilities of $2.5 million. Non-cash items primarily included amortization of developed technology of $11.2 million, stock-based compensation expense of $11.0 million, amortization of debt discounts and issuance costs of $8.4 million and depreciation and amortization of $5.4million. The net increase in assets52and liabilities was primarily due to lower accrued liabilities for retention bonuses, which were paid in November 2018 in the form of stock.Net cash used in operating activities in 2017 was $24.1 million and consisted of net loss of $60.5 million less non-cash adjustments of $27.2 million,and a net reduction in assets and liabilities of $9.2 million. Non-cash items primarily included amortization of developed technology of $11.2 million, stock-based compensation expense of $9.1 million, and depreciation and amortization of $7.4 million. The net change in assets and liabilities was primarily drivenby a decrease in inventory, an increase in deferred revenue, an increase in other liabilities and a decrease in prepaid expenses and other current assets.Net cash used in operating activities in 2016 was $39.1 million and consisted of net loss of $76.0 million less non-cash adjustments of $32.1 million,and a net decrease in assets and liabilities of $4.7 million. Non-cash items primarily included stock-based compensation expense of $13.9 million,amortization of developed technology of $11.2 million, and depreciation and amortization of $6.7 million. The net change in assets and liabilities wasprimarily driven by a decrease in accounts receivable, offset by an increase in inventory and a decrease in accounts payable.Net Cash Provided by Investing ActivitiesOur primary investing activities consist of purchases, sales, and maturities of our short-term investments and to a much lesser extent, capitalexpenditures for manufacturing, laboratory, computer equipment and software to support our infrastructure and work force. We expect to continue to incurcosts for capital expenditures for demonstration units and loaner equipment to support our sales and service efforts, and computer equipment and software tosupport our business operations. However, we may choose to decrease or defer certain capital expenditures and development activities, while furtheroptimizing our organization.Net cash provided by investing activities in 2018 was $4.7 million, which included proceeds from sales and maturities of investments of $6.5 million,offset by purchases of investments of $1.5 million and capital expenditures of $0.4 million to support our commercial and manufacturing operations.Net cash provided by investing activities in 2017 was $17.7 million, which included proceeds from sales and maturities of investments of $25.6million, offset by purchases of investments of $6.3 million and capital expenditures of $1.6 million to support our commercial and manufacturing operations.Net cash provided by investing activities in 2016 was $45.1 million, which included proceeds from sales and maturities of investments of $86.4 millionand proceeds from the sale of investment in Verinata of $2.3 million, offset by purchases of investments of $38.6 million and capital expenditures of $5.1million to support our commercial and manufacturing operations.Net Cash Provided by Financing ActivitiesWe generated cash from financing activities of $57.7 million during 2018. Approximately $59.5 million was generated from a public offering of ourcommon stock. The remainder reflects the proceeds from stock option exercises and ESPP purchases, offset by debt and equity issuance costs and payments oftaxes for the net settlement of equity awards. We generated cash from financing activities of $29.0 million during 2017, primarily due to a public equityoffering. In 2016, we generated cash of $0.1 million, primarily from proceeds received in connection with the exercise of options for our common stock.Capital ResourcesAt December 31, 2018 and December 31, 2017, our working capital, excluding deferred revenues, was $101.0 million and $71.6 million, respectively,including cash and cash equivalents of $95.4 million and $58.1 million, respectively, and short-term investments of $0.0 million and $5.1 million,respectively.In February 2014, we closed an underwritten public offering of $201.3 million in aggregate principal amount of our 2.75% Senior Convertible Notesdue 2034 (2014 Notes). In March 2018, we entered into privately negotiated transactions with certain holders of our 2014 Notes to exchange $150.0 millionin aggregate principal amount of the 2014 Notes for $150.0 million in aggregate principal amount of our new 2.75% Exchange Convertible Senior Notes due2034 (2018 Notes). Following the exchange transactions, approximately $51.3 million in aggregate principal amount of 2014 Notes remainedoutstanding. Our board of directors determined that the private exchange transactions were in our best interest and in the best interest of our stockholdersfollowing substantial review with management and our financial advisors concerning the amount of our outstanding indebtedness relative to the marketcapitalization of our common stock and, in particular, obligations under the53indenture for the 2014 Notes that could require us to repurchase the 2014 Notes beginning in 2021 at a repurchase price equal to the aggregate principalamount of the 2014 Notes (approximately $201.3 million prior to the exchange). The principal differences between the 2014 Notes and the 2018 Notes arethe following:•The date on which we may be first required to repurchase the 2018 Notes has been extended to February 2023, compared to February 2021 underthe 2014 Notes. In addition, while the applicable cash repurchase price for the 2014 Notes is 100% of the outstanding principal amount, the cashrepurchase price for the 2018 Notes is based on a formula that would result in the 2018 Notes being redeemed for up to an amount equal to 120%of the original principal amount, plus, in each case, accrued and unpaid interest.•The initial conversion price under the 2018 Notes is approximately $7.88, as compared to approximately $55.94 under the 2014 Notes. As a result,each of the outstanding 2018 Notes is initially convertible into 126.9438 shares of our common stock per $1,000 principal amount, while the 2014Notes are initially convertible into 17.8750 shares of our common stock per $1,000 principal amount.•Under the supplemental indenture for the 2018 Notes, we may at any time cause the then-outstanding 2018 Notes to be converted into shares of ourcommon stock at the then-applicable 2018 Note conversion price if the volume weighted average price of our common stock is at least 110% ofthe applicable 2018 Note conversion price on each applicable trading day over a period specified in the supplement indenture for the 2018 Notes. Under the indenture for the 2014 Notes, we may only redeem the 2014 Notes for cash under certain circumstances during the period from February6, 2018, through February 6, 2021.•Under certain circumstances such as a “fundamental change” (as defined in the applicable indenture) that occurs prior to (i) February 6, 2021, inthe case of the 2014 Notes and (ii) February 6, 2023, in the case of the 2018 Notes, holders of the Notes are entitled to a “make-whole” premiumthat will result in an increase in the applicable conversion rate. Under the terms of the 2018 Notes (but not the 2014 Notes), holders will be entitledto receive additional shares reflecting the economic equivalent of approximately two years of additional coupon payments, subject to certainlimitations, in connection with a voluntary conversion by the noteholder prior to our exercise of our early conversion option.The foregoing summaries of the 2014 Notes, the 2018 Notes, and the exchange transactions completed in March 2018 are not complete and arequalified in their entirety by the applicable indentures, forms of global notes, and other agreements and documents filed with the Securities and ExchangeCommission with respect to the 2018 Notes and the exchange, and investors should refer to the text of the Second Supplemental Indenture, dated March 6,2018, between Fluidigm Corporation and U.S. Bank National Association and the Form of Global Note included in the Second Supplemental Indenture,which are incorporated by reference as Exhibits 4.6 and 4.7, respectively, in our Annual Report on Form 10-K for the year ended December 31, 2017. Withrespect to the 2014 Notes, of which approximately $51.3 million in aggregate principal amount remains outstanding, investors should refer to the text of theIndenture, dated as of February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association, the First Supplemental Indenture, datedas of February 4, 2014, by and between Fluidigm Corporation and U.S. Bank National Association, and the Form of Global Note included in the FirstSupplemental Indenture which are incorporated by reference as Exhibits 4.2, 4.3 and 4.4, respectively, in our Annual Report on Form 10-K for the year endedDecember 31, 2017.On August 2, 2018, we entered into a Revolving Credit Facility with Silicon Valley Bank, which matures on August 2, 2020. Amounts drawn under theRevolving Credit Facility will be used for working capital and general corporate purposes. As of December 31, 2018, total availability under the RevolvingCredit Facility was $12.3 million. We currently have no outstanding debt under the Revolving Credit Facility, and we are in compliance with all the termsand conditions of the loan agreement governing the Revolving Credit Facility. See Note 6 to the Consolidated Financial Statements included in this Form10-K for more information about the Revolving Credit Facility.In early 2017, we implemented a retention incentive plan that provided for payment of cash bonuses in January 2019 to plan participants who wereemployees at the time the plan was implemented and who remained with Fluidigm through January 1, 2019. In September 2018, certain plan participantswere permitted to elect to surrender their right to receive all or a portion of the cash bonus in exchange for fully vested restricted stock units issued under our2011 Equity Incentive Plan. Among other reasons, our compensation committee adopted the exchange program to encourage employee stock ownership andto effectively manage cash resources. Participants opted to exchange approximately $2.4 million of cash bonus payments for approximately 380,000 fullyvested RSUs issued in November 2018. The cash bonus payments payable in January 2019 for plan participants that remain employed with Fluidigm throughJanuary 1, 2019 is approximately $3.3 million.54We believe our existing cash, cash equivalents, and investments will be sufficient to meet our working capital and capital expenditure needs for at leastthe next 18 months. However, we may experience lower than expected cash generated from operating activities or greater than expected capital expenditures,cost of revenue, or operating expenses, and we may need to raise additional capital to fund our operations, further our research and development activities, oracquire or invest in a business. Our future funding requirements will depend on many factors, including market acceptance of our products, the cost of ourresearch and development activities, the cost of filing and prosecuting patent applications, the cost associated with litigation or disputes relating tointellectual property rights or otherwise, the cost and timing of regulatory clearances or approvals, if any, the cost and timing of establishing additional sales,marketing, and distribution capabilities, the cost and timing of establishing additional technical support capabilities, and the effect of competingtechnological and market developments. In the future, we may acquire businesses or technologies from third parties, and we may decide to raise additionalcapital through debt or equity financing to the extent we believe this is necessary to successfully complete these acquisitions.If we require additional funds in the future, we may not be able to obtain such funds on acceptable terms, or at all. If we raise additional funds byissuing equity securities, our stockholders could experience dilution. Debt financing, if available, may involve covenants restricting our operations or ourability to incur additional debt. Any additional debt or equity financing that we raise may contain terms that are not favorable to us or our stockholders. If wedo not have, or are not able to obtain, sufficient funds, we may have to delay development or commercialization of our products or license to third parties therights to commercialize products or technologies that we would otherwise seek to commercialize. We also may have to reduce marketing, customer support,research and development, or other resources devoted to our products.Off-Balance Sheet ArrangementsSince our inception, we have not had any off-balance sheet arrangements as defined in Item 303(a)(4) of the Securities and Exchange Commission’sRegulation S-K.Contractual Obligations and CommitmentsThe following summarizes our contractual obligations as of December 31, 2018 (in thousands): Payments Due by Period Total Less than 1Year 1-3 Years 3-5 Years ThereafterLong term debt obligations $271,725 $5,534 $11,069 $189,074 $66,048Operating lease obligations, net 9,578 3,664 3,294 1,379 1,241Purchase obligations 1,596 1,596 — — —Total $282,899 $10,794 $14,363 $190,453 $67,289Debt obligations include the principal amount of the Notes and interest payments to be made under the Notes. Although the Notes mature in 2034, theycan be converted into cash and shares of our common stock prior to maturity if certain conditions are met. See Note 6 to our consolidated financial statementsfor additional information regarding the terms of the Notes.Our operating lease obligations, net of sublease income, relate to leases for our current headquarters and leases for manufacturing and office space forour foreign subsidiaries. Purchase obligations consist of contractual and legally binding commitments to purchase goods and services.We lease facilities and equipment under non-cancelable lease agreements expiring at various times through 2026. Our lease payments are expensed on astraight-line basis over the life of the leases. Rental expense under operating leases, net of amortization of lease incentive, totaled $5.0 million, $4.7 million,$6.3 million for 2018, 2017, and 2016, respectively.We have entered into several license and patent agreements. Under these agreements, we pay annual license maintenance fees, non-refundable licenseissuance fees, and royalties as a percentage of net sales for the sale or sublicense of products using the licensed technology. Future payments related to theselicense agreements have not been included in the contractual obligations table above as the period of time over which the future license payments will berequired to be made, and the amount of such payments, are indeterminable. We do not expect the license payments to be material in any particular year.55ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISKMarket risk represents the risk of loss that may impact our financial position due to adverse changes in financial market prices and rates. Our market riskexposure is primarily a result of fluctuations in foreign currency exchange rates and interest rates. We do not hold or issue financial instruments for tradingpurposes.Foreign Currency Exchange RiskAs we expand internationally our results of operations and cash flows will become increasingly subject to fluctuations due to changes in foreigncurrency exchange rates. Our revenue is generally denominated in the local currency of the contracting party. Historically, the majority of our revenue hasbeen denominated in U.S. dollars. Our expenses are generally denominated in the currencies in which our operations are located, which is primarily in theUnited States, with a portion of expenses incurred in Singapore and Canada where our manufacturing facilities are located. Our results of operations and cashflows are, therefore, subject to fluctuations due to changes in foreign currency exchange rates. The volatility of exchange rates depends on many factors thatwe cannot forecast with reliable accuracy. We have experienced and will continue to experience fluctuations in our net income or loss as a result oftransaction gains or losses related to revaluing certain current asset and current liability balances that are denominated in currencies other than the functionalcurrency of the entities in which they are recorded. For the years ended December 31, 2018 and 2017, we experienced foreign currency losses of $0.0 millionand $0.1 million, respectively. To date, we have not entered into any foreign currency hedging contracts although we may do so in the future. As ourinternational operations grow, we will continue to reassess our approach to manage our risk relating to fluctuations in currency rates. If foreign currencyexchange rates had changed by 10% during the periods presented, it would not have had a material impact on our financial position or results of operations.Interest Rate SensitivityWe had cash and cash equivalents of $95.4 million at December 31, 2018. These amounts were held primarily in cash on deposit with banks and moneymarket funds which are short-term. We had no investments at December 31, 2018. Cash and cash equivalents and investments are held for working capitalpurposes. We believe that we do not have any material exposure to changes in the fair value of our money market portfolio as a result of changes in interestrates. Declines in interest rates, however, will reduce future investment income. If overall interest rates had decreased by 10% during the periods presented,our interest income would not have been materially affected.Fair Value of Financial InstrumentsWe do not have material exposure to market risk with respect to investments. We do not use derivative financial instruments for speculative or tradingpurposes. We may adopt specific hedging strategies in the future.56ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATAIndex to Consolidated Financial Statements Page Report of PricewaterhouseCoopers LLP-Independent Registered Accounting Firm58 Consolidated Balance Sheets as of December 31, 2018 and 201760 Consolidated Statements of Operations for the years ended December 31, 2018, 2017 and 201661 Consolidated Statements of Comprehensive Loss for the years ended December 31, 2018, 2017 and 201662 Consolidated Statements of Stockholders' Equity for the years ended December 31, 2018, 2017 and 201663 Consolidated Statements of Cash Flows for the years ended December 31, 2018, 2017 and 201664 Notes to Consolidated Financial Statements65 Financial Statement Schedule Schedule II - Valuation and Qualifying Accounts for the years ended December 31, 2018, 2017 and 20169657Report of Independent Registered Public Accounting FirmTo the Board of Directors andStockholders of Fluidigm CorporationOpinions on the Financial Statements and Internal Control over Financial ReportingWe have audited the accompanying consolidated balance sheets of Fluidigm Corporation and its subsidiaries (the “Company”) as of December 31, 2018 and2017, and the related consolidated statements of operations, of comprehensive loss, of stockholders’ equity, and of cash flows for each of the three years inthe period ended December 31, 2018, including the related notes and financial statement schedule listed in the accompanying index (collectively referred toas the “consolidated financial statements”). We also have audited the Company's internal control over financial reporting as of December 31, 2018, based oncriteria established in Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission(COSO).In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of the Company as ofDecember 31, 2018 and 2017, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2018 inconformity with accounting principles generally accepted in the United States of America. Also in our opinion, the Company maintained, in all materialrespects, effective internal control over financial reporting as of December 31, 2018, based on criteria established in Internal Control - Integrated Framework(2013) issued by the COSO.Change in Accounting Principle As discussed in Note 2 to the consolidated financial statements, the Company changed the manner in which it accounts for revenues from contracts withcustomers in 2018.Basis for OpinionsThe Company’s management is responsible for these consolidated financial statements, for maintaining effective internal control over financial reporting,and for its assessment of the effectiveness of internal control over financial reporting, included in Management’s Report on Internal Control Over FinancialReporting. Our responsibility is to express opinions on the Company’s consolidated financial statements and on the Company’s internal control overfinancial reporting based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States)(PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules andregulations of the Securities and Exchange Commission and the PCAOB.We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain reasonableassurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud, and whether effective internalcontrol over financial reporting was maintained in all material respects.Our audits of the consolidated financial statements included performing procedures to assess the risks of material misstatement of the consolidated financialstatements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis,evidence regarding the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles usedand significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. Our audit of internalcontrol over financial reporting included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weaknessexists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audits also included performingsuch other procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinions.58Definition and Limitations of Internal Control over Financial ReportingA company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reportingand the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal controlover financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairlyreflect the transactions and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions are recorded as necessary to permitpreparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are beingmade only in accordance with authorizations of management and directors of the company; and (iii) provide reasonable assurance regarding prevention ortimely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation ofeffectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliancewith the policies or procedures may deteriorate./s/ PricewaterhouseCoopers LLPSan Jose, CaliforniaMarch 18, 2019We have served as the Company’s auditor since 2015.59FLUIDIGM CORPORATIONCONSOLIDATED BALANCE SHEETS(In thousands, except per share amounts) December 31, 2018 2017ASSETS Current assets: Cash and cash equivalents $95,401 $58,056Short-term investments — 5,080Accounts receivable (net of allowances of $126 and $391, at December 31, 2018 and 2017, respectively) 16,651 15,049Inventories 13,003 15,088Prepaid expenses and other current assets 2,051 1,528Total current assets 127,106 94,801Property and equipment, net 8,825 12,301Other non-current assets 6,208 7,541Developed technology, net 57,400 68,600Goodwill 104,108 104,108Total assets $303,647 $287,351LIABILITIES AND STOCKHOLDERS’ EQUITY Current liabilities: Accounts payable $4,027 $4,211Accrued compensation and related benefits 14,470 10,535Other accrued liabilities 7,621 8,490Deferred revenue, current 11,464 10,238Total current liabilities 37,582 33,474Convertible notes, net 172,058 195,238Deferred tax liability 13,714 16,919Deferred revenue, non-current 6,327 4,960Other non-current liabilities 1,850 5,825Total liabilities 231,531 256,416Commitments and contingencies Stockholders’ equity: Preferred stock, $0.001 par value, 10,000 shares authorized, no shares issued and outstanding at eitherDecember 31, 2018 or 2017 — —Common stock: $0.001 par value, 200,000 shares authorized at December 31, 2018 and 2017; 49,338 and38,787 shares issued and outstanding at December 31, 2018 and 2017, respectively 49 39Additional paid-in capital 631,605 531,666Accumulated other comprehensive loss (687) (574)Accumulated deficit (558,851) (500,196)Total stockholders’ equity 72,116 30,935Total liabilities and stockholders’ equity $303,647 $287,351See accompanying notes60FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF OPERATIONS(In thousands, except per share amounts) Year Ended December 31, 2018 2017 2016Revenue: Product revenue $93,650 $84,399 $89,003Service revenue 19,314 17,348 15,205License revenue — 190 238Total revenue 112,964 101,937 104,446Cost of sales: Cost of product revenue 44,861 45,039 41,110Cost of service revenue 6,454 4,916 4,899Total cost of sales 51,315 49,955 46,009Gross profit 61,649 51,982 58,437Operating expenses: Research and development 30,030 30,826 38,415Selling, general and administrative 79,783 79,516 93,212Total operating expenses 109,813 110,342 131,627Loss from operations (48,164) (58,360) (73,190)Interest expense (13,893) (5,824) (5,820)Other income (expense), net 637 385 (1,167)Loss before income taxes (61,420) (63,799) (80,177)Benefit from income taxes 2,407 3,264 4,192Net loss (59,013) (60,535) (75,985)Net loss per share, basic and diluted $(1.49) $(1.84) $(2.62)Shares used in computing net loss per share, basic and diluted 39,652 32,980 29,008See accompanying notes61FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS(In thousands) Year Ended December 31, 2018 2017 2016Net loss $(59,013) $(60,535) $(75,985)Other comprehensive income (loss), net of tax Foreign currency translation adjustment (112) 183 314Unrealized gain (loss) on available-for-sale securities, net (1) 3 70Other comprehensive income (loss) (113) 186 384Comprehensive loss $(59,126) $(60,349) $(75,601)See accompanying notes62FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY(in thousands) Common Stock AdditionalPaid-inCapital AccumulatedOtherComprehensive(Loss)/Income AccumulatedDeficit TotalStockholders’Equity Shares Amount Balance at December 31, 2015 28,844 $29 $479,508 $(1,144) $(363,492) $114,901Issuance of restricted stock, net of shares withheld for taxes,and other 307 — (152) — — (152)Issuance of common stock from option exercises 57 — 227 — — 227Stock-based compensation expense — — 13,858 — — 13,858Net loss — — — — (75,985) (75,985)Other comprehensive income — — — 384 — 384Balance at December 31, 2016 29,208 $29 $493,441 $(760) $(439,477) $53,233At-the-market offering 9,091 9 28,793 — — 28,802Issuance of restricted stock, net of shares withheld for taxes,and other 413 1 (166) — — (165)Issuance of common stock from option exercises 25 — 100 — — 100Issuance of common stock under ESPP 50 — 222 — — 222Cumulative-effect of new accounting standard for Topic 718Stock Compensation — — 184 — (184) —Stock-based compensation expense — — 9,092 — — 9,092Net loss — — — — (60,535) (60,535)Other comprehensive income — — — 186 — 186Balance at December 31, 2017 38,787 $39 $531,666 $(574) $(500,196) $30,935Market offering 9,373 9 59,084 — — 59,093Issuance of restricted stock, net of shares withheld for taxes,and other 886 1 (379) — — (378)Issuance of common stock from option exercises 40 — 208 — — 208Issuance of common stock under ESPP 252 — 1,203 — — 1,203Conversion option on convertible debt — — 29,357 — — 29,357Closing cost related to conversion option on convertible debt — — (557) — — (557)Cumulative-effect of new accounting standard for Topic 606Revenue — — — — 358 358Stock-based compensation expense — — 11,023 — — 11,023Net loss — — — — (59,013) (59,013)Other comprehensive loss — — — (113) — (113)Balance at December 31, 2018 49,338 $49 $631,605 $(687) $(558,851) $72,116 See accompanying notes63FLUIDIGM CORPORATIONCONSOLIDATED STATEMENTS OF CASH FLOWS(In thousands) Year Ended December 31, 2018 2017 2016Operating activities Net loss $(59,013) $(60,535) $(75,985)Adjustments to reconcile net loss to net cash used in operating activities: Depreciation and amortization 5,372 7,409 6,738Stock-based compensation expense 11,023 9,092 13,858Amortization of developed technology 11,200 11,200 11,200Amortization of debt discounts, premiums and issuance costs 8,379 287 278Other non-cash items 175 (890) (26)Loss on disposal of property and equipment 141 135 87Changes in assets and liabilities: Accounts receivable (1,788) (554) 10,521Inventories 1,488 4,596 (3,387)Prepaid expenses and other assets 178 1,583 (457)Accounts payable (294) 585 (2,271)Deferred revenue 2,574 1,636 (274)Other liabilities (4,636) 1,358 580Net cash used in operating activities (25,201) (24,098) (39,138)Investing activities Purchases of investments (1,450) (6,276) (38,594)Proceeds from sales and maturities of investments 6,541 25,550 86,431Proceeds from sale of investment in Verinata — — 2,330Purchases of intangible assets — (50) —Purchases of property and equipment (372) (1,566) (5,065)Net cash provided by investing activities 4,719 17,658 45,102Financing activities Payment of debt and equity issuance costs (2,862) — —Net proceeds from issuance of common stock 59,469 28,793 —Proceeds from exercise of stock options 208 100 227Proceeds from stock issuance from ESPP 1,203 222 —Payments for taxes related to net share settlement of equity awards (358) (118) (111)Net cash provided by financing activities 57,660 28,997 116Effect of foreign exchange rate fluctuations on cash and cash equivalents 167 454 (152)Net increase in cash and cash equivalents 37,345 23,011 5,928Cash and cash equivalents at beginning of period 58,056 35,045 29,117Cash and cash equivalents at end of period $95,401 $58,056 $35,045Supplemental disclosures of cash flow information Cash paid for interest $5,534 $5,534 $5,534Cash paid for income taxes, net of refunds $321 $245 $355See accompanying notes64NOTES TO CONSOLIDATED FINANCIAL STATEMENTSDecember 31, 20181. Description of BusinessFluidigm Corporation (we, our, or us) was incorporated in the State of California in May 1999 to commercialize microfluidic technology initiallydeveloped at the California Institute of Technology. In July 2007, we were reincorporated in Delaware. Our headquarters are located in South San Francisco,California.We create, manufacture, and market innovative technologies and life science tools, including preparatory and analytical instruments for MassCytometry, PCR, Library Prep, Single Cell Genomics, and consumables, including IFCs, assays, and reagents. Our focus is on the most pressing needs intranslational and clinical research, including cancer, immunology and immunotherapy. We use proprietary CyTOF® and microfluidics technologies todevelop innovative end-to-end solutions that have the flexibility required to meet the needs of translational research and the robustness to support high-impact clinical research studies. We sell our instruments to leading academic research institutions, translational research and medicine centers, cancer centers,clinical research laboratories, and biopharmaceutical, biotechnology and Ag-Bio companies.2. Summary of Significant Accounting PoliciesBasis of Presentation and ConsolidationThe accompanying consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles (U.S.GAAP) and include the accounts of our wholly-owned subsidiaries. As of December 31, 2018, we had wholly-owned subsidiaries in Singapore, Canada, theNetherlands, Japan, France, the United Kingdom, China, and Germany. All subsidiaries, except for Singapore, use their local currency as their functionalcurrency. The Singapore subsidiary uses the U.S. dollar as its functional currency. All intercompany transactions and balances have been eliminated inconsolidation.Certain prior period amounts in the consolidated statements of stockholders’ equity and consolidated statements of cash flows were reclassified toconform with the current period presentation. These reclassifications were immaterial and did not affect prior period total assets, total liabilities, stockholders'equity, total revenue, total costs and expenses, loss from operations or net loss.Use of EstimatesThe preparation of financial statements in accordance with U.S. GAAP requires management to make estimates and assumptions that affect the amountsreported in the consolidated financial statements and accompanying notes. We base our estimates on historical experience and on various other assumptionsbelieved to be reasonable, which together form the basis for making judgments about the carrying values of assets and liabilities. Actual results could differmaterially from these estimates and could have a material adverse effect on our consolidated financial statements.Foreign CurrencyAssets and liabilities of non-U.S. subsidiaries that use the local currency as their functional currency are translated into U.S. dollars at exchange rates ineffect on the balance sheet date. The adjustments resulting from the foreign currency translations are recorded in accumulated other comprehensive loss, aseparate component of stockholders’ equity. Income and expense accounts are translated at monthly average exchange rates during the year.Revenue RecognitionWe generate revenue primarily from the sale of our products and services. Product revenue is derived from the sale of instruments and consumables,including IFCs, assays and reagents. Service revenue is derived from the sale of instrument service contracts, repairs, installation, training and otherspecialized product support services. Revenue is reported net of any sales, use and value-added taxes we collect from customers as required by governmentauthorities.65We recognize revenue based on the amount of consideration we expect to receive in exchange for the goods and services we transfer to the customer.Our commercial arrangements typically include multiple distinct products and services, and we allocate revenue to these performance obligations based ontheir relative standalone selling prices. Standalone selling prices (SSP) are generally determined using observable data from recent transactions. In caseswhere sufficient data is not available, we estimate a product’s SSP using a cost plus a margin approach or by applying a discount to the product’s list price.Product RevenueWe recognize product revenue at the point in time when control of the goods passes to the customer and we have an enforceable right to payment. Thisgenerally occurs either when the product is shipped from one of our facilities or when it arrives at the customer’s facility, based on the contractual terms.Customers generally do not have a unilateral right to return products after delivery. Invoices are generally issued at shipment and generally become due in 30to 60 days.We sometimes perform shipping and handling activities after control of the product passes to the customer. We have made an accounting policyelection to account for these activities as product fulfillment activities rather than as separate performance obligations.Service RevenueWe recognize revenue from repairs, installation, training and other specialized product support services at the point in time the work is completed.Installation and training services are generally billed in advance of service. Repairs and other services are generally billed at the point the work is completed.Revenue associated with instrument service contracts is recognized on a straight-line basis over the life of the agreement, which is generally one to threeyears. We believe this time-elapsed approach is appropriate for service contracts because we provide services on demand throughout the term of theagreement. Invoices are generally issued in advance of service on a monthly, quarterly, annual or multi-year basis. Payments made in advance of service arereported on our consolidated balance sheet as deferred revenue.Contract CostsIncremental sales commission costs incurred to obtain instrument service contracts are capitalized and amortized to selling, general and administrativeexpense over the life of the contract, which is generally one to three years. As a practical expedient, we expense sales commissions associated with productsupport services that are delivered in less than one year as they are incurred. Sales commissions associated with the sale of products are expensed as they areincurred.Product WarrantiesWe generally provide a one-year warranty on our instruments. We accrue for estimated warranty obligations at the time of product shipment. Weperiodically review our warranty liability and record adjustments based on the terms of warranties provided to customers, and historical and anticipatedwarranty claim experience. This expense is recorded as a component of cost of product revenue in the consolidated statements of operations.Significant JudgmentsApplying the revenue recognition practices discussed above often requires significant judgment. Judgment is required when identifying performanceobligations, estimating SSP and allocating purchasing consideration in multi-element arrangements and estimating the future amount of our warrantyobligations. Moreover, significant judgment is required when interpreting commercial terms and determining when control of goods and services passes tothe customer. Any material changes created by errors in judgment could have a material effect on our operating results and overall financial condition.66Cash and Cash EquivalentsWe consider all highly liquid financial instruments with maturities at the time of purchase of three months or less to be cash equivalents. Cash and cashequivalents may consist of cash on deposit with banks, money market funds, and notes from government-sponsored agencies.InvestmentsShort-term investments are comprised of notes from government-sponsored agencies. All investments are recorded at estimated fair value. Anyunrealized gains and losses from investments are reported in accumulated other comprehensive loss, a separate component of stockholders’ equity. Weevaluate our investments to assess whether investments with unrealized loss positions are other-than-temporarily impaired. An investment is considered to beother-than-temporarily impaired if the impairment is related to deterioration in credit risk or if it is likely that we will sell the securities before the recovery oftheir cost basis. No investment has been assessed as other than temporarily impaired, and realized gains and losses were immaterial during the yearspresented. The cost of securities sold, or the amount reclassified out of accumulated other comprehensive income into earnings is based on the specific-identification method.Accounts ReceivableTrade accounts receivable are recorded at net invoice value. We review our exposure to accounts receivable and provide allowances of specificamounts if collectability is no longer reasonably assured based on historical experience and specific customer collection issues. We evaluate such allowanceson a regular basis and adjust them as needed.Concentrations of Business and Credit RiskFinancial instruments that potentially subject us to credit risk consist of cash, cash equivalents, investments, and accounts receivable. Our cash, cashequivalents, and investments may consist of deposits held with banks, money market funds, and other highly liquid investments that may at times exceedfederally insured limits. Cash equivalents and investments are financial instruments that potentially subject us to concentrations of risk. Under ourinvestment policy, we invest primarily in securities issued by the U.S. government. The goals of our investment policy, in order of priority, are as follows:preserve capital, meet liquidity needs, and optimize returns.We generally do not require collateral to support credit sales. To reduce credit risk, we perform credit evaluations of our customers. No single customerrepresented more than 10% of total revenue for 2018, 2017, or 2016, and no single customer represented more than 10% of total accounts receivable atDecember 31, 2018, 2017, or 2016.Our products include components that are currently procured from a single source or a limited number of sources. We believe that other vendors wouldbe able to provide similar components; however, the qualification of such vendors may require start-up time. In order to mitigate any adverse impacts from adisruption of supply, we attempt to maintain an adequate supply of critical limited-source components.InventoriesInventories are stated at the lower of cost (on a first-in, first-out basis) or net realizable value. Inventory costs include direct materials, direct labor, andnormal manufacturing overhead. Finished goods that are used for research and development are expensed as consumed or depreciated over their period ofuse. Provisions for slow-moving, excess, and obsolete inventories are recorded when required to reduce inventory values to their estimated net realizablevalues based on product life cycle, development plans, product expiration, and quality issues.Property and EquipmentProperty and equipment, including leasehold improvements, are stated at cost less accumulated depreciation. Accumulated depreciation is calculatedusing the straight-line method over the estimated useful lives of the assets. Leasehold improvements are amortized using the straight-line method over theestimated useful lives of the assets or the remaining term of the lease, whichever is shorter. The estimated useful lives of our property and equipment aregenerally as follows: computer67equipment and software, three to four years; laboratory and manufacturing equipment, two to five years; and office furniture and fixtures, five years.Depreciation expense for the years ended December 31, 2018, 2017, and 2016 was $4.2 million, $5.9 million, and $5.1 million, respectively.Goodwill, Intangible Assets and Other Long-Lived AssetsGoodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Our intangible assets include developedtechnology, patents and licenses. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets’respective estimated useful lives.Goodwill and intangible assets with indefinite lives are not subject to amortization but are tested for impairment on an annual basis during the fourthquarter or whenever events or changes in circumstances indicate the carrying amount of these assets may not be recoverable. We first conduct an assessmentof qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than its carrying amount. If we determinethat it is more likely than not that the fair value of our reporting unit is less than its carrying amount, we then conduct a two-step test for impairment ofgoodwill. In the first step, we compare the fair value of our reporting unit to its carrying value. If the fair value of our reporting unit exceeds its carrying value,goodwill is not considered impaired and no further analysis is required. If the carrying value of the reporting unit exceed its fair value, then the second step ofthe impairment test must be performed in order to determine the implied fair value of the goodwill. If the carrying value of the goodwill exceeds its impliedfair value, then an impairment loss equal to the difference would be recorded.We evaluate our long-lived assets, including finite-lived intangibles, for indicators of possible impairment when events or changes in circumstancesindicate the carrying amount of an asset may not be recoverable. If any indicator of impairment exists, we assess the recoverability of the affected long-livedassets by determining whether the carrying value of the asset can be recovered through undiscounted future operating cash flows. If impairment is indicated,we estimate the asset’s fair value using future discounted cash flows associated with the use of the asset, and adjust the carrying value of the assetaccordingly. We did not recognize any impairment of long-lived assets for any of the periods presented herein.Convertible NotesIn February 2014, we closed an underwritten public offering $201.3 million aggregate principal amount of our 2.75% Senior Convertible Notes due2034 (2014 Notes). In March 2018, we entered into separate privately negotiated transactions with certain holders of our 2014 Notes to exchange $150.0million in aggregate principal amount of the 2014 Notes for our new 2.75% Exchange Convertible Senior Notes due 2034 (2018 Notes). Following theexchange, approximately $51.3 million in aggregate principal amount of the 2014 Notes remained outstanding in addition to $150.0 million in aggregateprincipal amount of the 2018 Notes.As the 2018 Notes are convertible, at our election, into cash, shares of our common stock, or a combination of cash and shares of our common stock, weaccounted for the 2018 Notes under the cash conversion guidance in ASC 470, whereby the embedded conversion option in the 2018 Notes was separatedand accounted for in equity. The embedded conversion option value was calculated as the difference between (i) the total fair value of the 2018 Notes and (ii)the fair value of a similar debt instrument excluding the embedded conversion option. We determined an embedded conversion option value of $29.3million, which was recorded in additional paid-in-capital and reduced the carrying value of the 2018 Notes. The resulting discount on the 2018 Notes will beamortized over the expected term of the 2018 Notes, using the effective interest method through the first note holder put date, of February 6, 2023.For both the 2014 Notes and 2018 Notes, offering-related costs, including underwriting costs are capitalized as debt issuance costs, recorded as an offsetto the carrying value of the related Notes, and are being be amortized over the expected term of the related Notes using the effective interest method.68Fair Value of Financial InstrumentsOur financial instruments consist primarily of cash and cash equivalents, investments, accounts receivable, accounts payable, and convertible notes.Our cash equivalents, investments, accounts receivable, and accounts payable have short maturity or payment periods. Accordingly, their carrying valuesapproximated their fair values at December 31, 2018 and 2017. The convertible notes are presented at their carrying value, with fair value disclosures made inNote 7. As a basis for considering fair value, we follow a three-tier value hierarchy, which prioritizes the inputs used in measuring fair value as follows:Level I: observable inputs such as quoted prices in active markets;Level II: inputs other than quoted prices in active markets that are observable either directly or indirectly; andLevel III: unobservable inputs for which there is little or no market data, which requires us to develop our own assumptions.This hierarchy requires us to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value.Our cash equivalents, which include money market funds, are classified as Level I because they are valued using quoted market prices. Our investments andconvertible notes are generally classified as Level II because their value is based on valuations using significant inputs derived from or corroborated byobservable market data. Depending on the security, the income and market approaches are used in the model driven valuations. Inputs of these modelsinclude recently executed transaction prices in securities of the issuer or comparable issuers and yield curves.Research and DevelopmentWe recognize research and development expenses in the period incurred. Research and development expenses consist of personnel costs, independentcontractor costs, prototype and materials expenses, allocated facilities and information technology expenses, and related overhead expenses.Advertising CostsWe expense advertising costs as incurred. We incurred advertising costs of $2.2 million, $1.8 million and $2.3 million during 2018, 2017, and 2016,respectively.Income TaxesWe use the asset and liability method to account for income taxes. Deferred tax assets and liabilities are recognized for the future tax consequencesattributable to temporary differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases.Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differencesare expected to be recovered or settled. Valuation allowances are provided when the expected realization of deferred tax assets does not meet a “more likelythan not” criterion. We make estimates and judgments about our future taxable income that are based on assumptions that are consistent with our plans andestimates. Should the actual amounts differ from our estimates, the amount of our valuation allowance could be materially impacted. Changes in theseestimates may result in significant increases or decreases to our tax provision in a period in which such estimates are changed, which in turn would affect netincome or loss.We recognize the financial statement effects of a tax position when it is more likely than not, based on the technical merits, that the position will besustained upon examination. Any interest and penalties related to uncertain tax positions are reflected in the income tax provision.69Stock-Based CompensationWe account for stock options and restricted stock units granted to employees and directors and stock purchases under ESPP based on the fair value ofthe awards. We recognize stock-based compensation expense on a straight-line basis over the requisite service periods for non-performance-based awards. Forperformance-based stock awards, stock-based compensation expense is recognized over the requisite service period when the achievement of each individualperformance goal becomes probable. Comprehensive LossComprehensive loss is comprised of net loss and other comprehensive income (loss). Other comprehensive income (loss) consists of unrealized gainsand losses on our investments and foreign currency translation adjustments. Total comprehensive loss for all periods presented has been disclosed in theconsolidated statements of comprehensive loss.The components of accumulated other comprehensive loss, net of tax, for the years ended December 31, 2018, 2017, and 2016 are as follows (inthousands): Foreign CurrencyTranslationAdjustment Unrealized Gain (Loss)on Investments Accumulated OtherComprehensive Income(Loss)Ending balance at December 31, 2016 $(758) $(2) $(760)Change during the year 183 3 186Ending balance at December 31, 2017 $(575) $1 $(574)Change during the year (112) (1) (113)Ending balance at December 31, 2018 $(687) $— $(687)Immaterial amounts of unrealized gains and losses have been reclassified into the consolidated statement of operations for the years ended December31, 2018, 2017 and 2016.Net Loss per ShareOur basic and diluted net loss per share is calculated by dividing net loss by the weighted-average number of shares of common stock outstanding forthe period. Restricted stock units and options to purchase our common stock are considered to be potentially dilutive common shares but have beenexcluded from the calculation of diluted net loss per share as their effect is anti-dilutive for all periods presented.The following potentially dilutive common shares were excluded from the computations of diluted net loss per share for the periods presented becauseincluding them would have been anti-dilutive (in thousands): December 31, 2018 2017 2016Stock options, restricted stock units and performance awards 4,354 3,501 4,6222018 Convertible Notes 19,035 — —2018 Convertible Notes potential make-whole shares 757 — —2014 Convertible Notes 916 3,598 3,598Total 25,062 7,099 8,22070Recent Accounting Changes and Accounting PronouncementsAdoption of New Accounting GuidanceIn May 2014, the FASB issued ASU 2014-09 Revenue from Contracts with Customers (Topic 606). Topic 606 and its related amendments supersedeRevenue Recognition (Topic 605), issued in June 2010, and provide principles for recognizing revenue for goods and services in a manner consistent withthe transfer of control of those goods and services to the customer.We adopted Topic 606 on January 1, 2018, using the modified retrospective method applied to those contracts with unrecognized revenue on theadoption date. We recognized the effect of applying the new revenue standard by recording a cumulative catch-up adjustment that reduced the accumulateddeficit component of stockholders’ equity by $0.4 million and increased current assets by $0.2 million and non-current assets by $0.2 million. Theadjustment capitalized certain sales commission costs that were incurred to obtain instrument service contracts. Under Topic 605, we accounted for theseincremental contract acquisition costs by recognizing them as expense at the point the contract was awarded. Under Topic 606, the costs are capitalized andamortized to expense over the life of the contract, which is generally one to three years. The comparative information for periods prior to January 1, 2018, hasnot been restated and continues to be reported in accordance with Topic 605.The following table summarizes the cumulative effect of adopting Topic 606 on amounts previously reported in our consolidated balance sheet atDecember 31, 2017 (in thousands): Balance at December31, 2017 Topic 606 TransitionAdjustments Balance at January1, 2018Prepaid expenses and other current assets $1,528 $153 $1,681Total current assets $94,801 $153 $94,954Other non-current assets $7,541 $205 $7,746Total assets $287,351 $358 $287,709Accumulated deficit $(500,196) $358 $(499,838)Total stockholders' equity $30,935 $358 $31,293Total liabilities and stockholders' equity $287,351 $358 $287,709The following table summarizes the impacts on our consolidated statements of operations of adopting Topic 606 compared to Topic 605 for the twelvemonths ended December 31, 2018 (in thousands): As Reported Balance WithoutAdoption of Topic 606 Effect of Change Twelve Months Ended December 31, 2018Selling, general and administrative $79,783 $79,859 $(76)Total costs and expenses $161,128 $161,204 $(76)Loss from operations $(48,164) $(48,240) $76Loss before income taxes $(61,420) $(61,496) $76Net loss $(59,013) $(59,089) $7671The following table summarizes the impacts on our consolidated balance sheets of adopting Topic 606 compared to Topic 605 at December 31, 2018(in thousands): As Reported Balance WithoutAdoption ofTopic 606 Effect of Change December 31, 2018 Prepaid expenses and other current assets $2,051 $1,884 $167Total current assets $127,106 $126,939 $167Other non-current assets $6,208 $5,941 $267Total assets $303,647 $303,213 $434Stockholders' equity $72,116 $71,682 $434Total liabilities and stockholders' equity $303,647 $303,213 $434In March 2018, the FASB issued ASU No. 2018-05, Income Taxes (Topic 740): Amendments to SEC Paragraphs Pursuant to SEC Staff AccountingBulletin No. 118. This ASU allows SEC reporting companies to record provisional amounts in earnings for the year ended December 31, 2017, due to thecomplexities involved in accounting for the enactment of the Tax Act. We recognized the estimated income tax effects of the Tax Act in its 2017Consolidated Financial Statements in accordance with SEC Staff Accounting Bulletin No. 118 (“SAB No. 118”). In accordance with SAB No. 118, wecompleted the accounting related to tax reform in the fourth quarter of 2018 and no material adjustments to the provisional tax expense was required. Refer toNote 10 for further information regarding the provisional amounts recorded by the Company.In February 2018, the FASB issued ASU 2018-02 Income Statement - Reporting Comprehensive Income (Topic 220): Reclassification of Certain TaxEffects from Accumulated Other Comprehensive Income. This ASU amends the reporting of comprehensive income to allow a reclassification fromaccumulated other comprehensive income to retained earnings for stranded tax effects resulting from the Tax Cuts and Jobs Act (the Tax Act). The Tax Actwas enacted in December 2017 and reduced the U.S federal corporate income tax rate and made other changes to U.S. federal tax law. ASU 2018-02 iseffective for our fiscal year beginning January 1, 2019, and early adoption is permitted. This standard did not have a material effect on our consolidatedfinancial statements.In August 2016, the FASB issued ASU 2016-15 Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments. TheASU addresses eight specific cash flow issues and their presentation within the statement of cash flows. We adopted this ASU in the first quarter of 2018. Theadoption of this ASU did not have a material impact on our consolidated financial statements.In November 2016, the FASB issued ASU 2016-18 Statement of Cash Flows (Topic 230): Restricted Cash, a consensus of the FASB’s Emerging IssuesTask Force, amending the presentation of restricted cash within the statement of cash flows. The new guidance requires that restricted cash be included withincash and cash equivalents on the statement of cash flows. We adopted this ASU in the first quarter of 2018. The adoption of this ASU did not have a materialimpact on our consolidated financial statements.Recent Accounting PronouncementsIn August 2018, the FASB issued ASU 2018-15 Intangibles—Goodwill and Other—Internal-Use Software (Subtopic 350-40) which establishes newguidance on the accounting for costs incurred to implement a cloud computing arrangement that is considered a service arrangement. The new guidancerequires the capitalization of such costs, aligning it with the accounting for costs associated with developing or obtaining internal-use software. The newguidance is effective for fiscal years beginning after December 15, 2019. We are currently evaluating the impact of adoption on our consolidated financialstatements.In February 2016, the FASB established Topic 842, Leases, by issuing Accounting Standards Update (ASU) No. 2016-02, which requires lessees torecognize leases on-balance sheet and disclose key information about leasing arrangements. Topic 842 was subsequently amended by ASU No. 2018-01,Land Easement Practical Expedient for Transition to Topic 842; ASU No. 2018-10, Codification Improvements to Topic 842, Leases; and ASU No. 2018-11,Targeted Improvements. The new standard72establishes a right-of-use (“ROU”) model that requires a lessee to recognize a ROU asset and lease liability on the balance sheet for all leases with a termlonger than 12 months. Leases will be classified as finance or operating; the classification will impact the expense recognition in the income statement.Modified Retrospective Transition approach is required, applying the new standard to all leases existing at the date of initial application. An entity maychoose to use either (1) its effective date or (2) the beginning of the earliest comparative period presented in the financial statements as its date of initialapplication. We expect to adopt the new standard on January 1, 2019 and use the effective date as our date of initial application. Consequently, financialinformation will not be updated, and the disclosures required under the new standard will not be provided for dates and periods before January 1, 2019. Fordates and periods prior to January 1, 2019, the original disclosures under ASC 840 will be disclosed.The new standard provides several optional practical expedients in transition. We expect to elect the ‘package of practical expedients’, which permitsus not to reassess under the new standard our prior conclusions about lease identification, lease classification and initial direct costs. We do not expect toelect the use-of-hindsight or the practical expedient pertaining to land easements; the latter not being applicable to us.We expect that this standard will have a material effect on our financial statements. While we continue to assess all the effects of adoption, we currentlybelieve the most significant effects relate to the recognition of new ROU assets and lease liabilities on our balance sheet for our building, vehicle andequipment leases. On adoption, we currently expect to recognize $8.0 million to $11.0 million of additional operating liabilities, based on the present value of theremaining fixed rental payments under current leasing standards for existing operating leases, with corresponding ROU assets of approximately $6.0 millionto $9.0 million. The difference between the initial lease liability and right of use asset is attributable to deferred rent. We do not expect any impact onretained earnings from the adoption of ASC 842.The new standard also provides certain accounting elections for an entity’s ongoing accounting. We currently expect to elect the short-term leaserecognition exemption for all leases that qualify. This means, for those leases that qualify, we will not recognize ROU assets or lease liabilities. We alsocurrently expect to elect to not separate lease and nonlease components for our building leases and to take a portfolio approach for our vehicles leases bycountry.In January 2017, the FASB issued ASU 2017-04, Intangibles - Goodwill and Other (Topic 350): Simplifying the Test for Goodwill Impairment. The ASUeliminates the requirement for an entity to calculate the implied fair value of goodwill to measure a goodwill impairment charge. Instead, an entity performsits annual, or interim, goodwill impairment testing by comparing the fair value of a reporting unit with its carrying amount and recording an impairmentcharge for the amount by which the carrying amount exceeds the fair value. The ASU will be effective for annual and interim goodwill impairment testingperformed for our fiscal year beginning January 1, 2020, with early adoption permitted. We are currently evaluating the effect that the updated standard willhave on our consolidated financial statements.3. RevenueDisaggregation of RevenueThe following table presents our revenue for the year ended December 31, 2018, 2017, and 2016, respectively, based on geographic area and byproducts and services (in thousands): Year Ended December 31, 2018 2017 2016Geographic Markets: Americas$51,172 $49,290 $56,229EMEA36,617 32,642 29,739Asia-Pacific25,175 20,005 18,478Total$112,964 $101,937 $104,44673 Year Ended December 31, 2018 2017 2016Products and Services: Instruments$45,491 $42,505 $46,834Consumables48,159 41,894 42,169Product revenue93,650 84,399 89,003Services19,314 17,348 15,205License— 190 238Total$112,964 $101,937 $104,446Performance ObligationsWe reported $15.2 million of deferred revenue on our December 31, 2017 consolidated balance sheet. During the twelve months ended December 31,2018, $9.1 million of the opening balance was recognized as revenue and $11.7 million of net additional advance payments were received from customers,primarily associated with instrument service contracts. At December 31, 2018, we reported $17.8 million of deferred revenue.The following table summarizes the expected timing of revenue recognition for unfulfilled performance obligations associated with instrument servicecontracts that were partially completed at December 31, 2018 (in thousands):Fiscal Year Expected Revenue (1)2019 $10,0372020 5,1492021 2,525Thereafter 1,436Total $19,147_______(1) Expected revenue includes both billed amounts included in deferred revenue and unbilled amounts that are not reflected in our consolidated financialstatements and are subject to change if our customers decide to cancel or modify their contracts. Purchase orders for instrument service contracts cangenerally be canceled before the service period begins without penalty.We apply the practical expedient that permits us to not disclose information about unsatisfied performance obligations for service contracts with anexpected term of one year or less.Contract CostsWe reported $0.4 million of capitalized commission costs from instrument service contracts at December 31, 2018 in the consolidated balance sheet.744. Goodwill and Intangible Assets, netIn connection with our acquisition of DVS in February 2014, we recognized goodwill of $104.1 million. Intangible assets include developedtechnology related to the DVS acquisition and other intangible assets included in Other non-current assets.Developed Technology, Patents and LicensesDeveloped technology as a result of the DVS acquisition, and patents and licenses, were as follows (in thousands): December 31, 2018 Gross Amount AccumulatedAmortization Net Weighted-AverageAmortization PeriodDeveloped technology $112,000 $(54,600) $57,400 10.0 yearsPatents and licenses $11,274 $(6,861) $4,413 7.8 years December 31, 2017 Gross Amount AccumulatedAmortization Net Weighted-AverageAmortization PeriodDeveloped technology $112,000 $(43,400) $68,600 10.0 yearsPatents and licenses $11,274 $(5,721) $5,553 7.8 yearsTotal amortization expense for the years ended December 31, 2018, December 31, 2017, and December 31, 2016 was $12.3 million, $12.4 million and$12.4 million, respectively.Based on the carrying value of intangible assets, net, as of December 31, 2018, the annual amortization expense is expected to be as follows (inthousands):Fiscal YearDeveloped TechnologyAmortization Expense Patents and LicensesAmortization Expense Total2019$11,200 $1,046 $12,246202011,200 1,046 12,246202111,200 888 12,088202211,200 815 12,015202311,200 610 11,810Thereafter1,400 8 1,408Total$57,400 $4,413 $61,813755. Balance Sheet DetailsCash and Cash EquivalentsCash and cash equivalents consisted of the following as of December 31, 2018 and 2017 (in thousands): December 31,Cash and cash equivalents: 2018 2017Cash $17,685 $20,129Money market funds 77,716 16,142 U.S. Government and agency securities — 21,785Total $95,401 $58,056InventoriesInventories consisted of the following as of December 31, 2018 and 2017 (in thousands): December 31,Inventories: 2018 2017Raw materials $5,996 $7,566Work-in-process 650 929Finished goods 6,357 6,593Total inventories, net $13,003 $15,088Property and Equipment, netProperty and equipment consisted of the following as of December 31, 2018 and 2017 (in thousands): December 31,Property and equipment: 2018 2017Computer equipment and software $4,201 $4,179Laboratory and manufacturing equipment 18,780 20,069Leasehold improvements 7,173 7,799Office furniture and fixtures 1,506 1,892Property and equipment, gross 31,660 33,939Less accumulated depreciation and amortization (22,855) (21,646)Construction-in-progress 20 8Property and equipment, net $8,825 $12,301 Product WarrantiesActivity for our warranty accrual for the years ended December 31, 2018 and 2017, which are included in other accrued liabilities, is summarized below(in thousands): Year Ended December 31, 2018 2017Beginning balance $699 $1,023Accrual for current period warranties 1,573 695Warranty costs incurred (1,409) (1,019)Ending balance $863 $699766. Convertible Notes and Credit Facility2014 Senior Convertible Notes (2014 Notes)On February 4, 2014, we closed an underwritten public offering of $201.3 million aggregate principal amount of our 2.75% Senior Convertible Notesdue 2034 (2014 Notes) pursuant to an underwriting agreement, dated January 29, 2014. The 2014 Notes accrue interest at a rate of 2.75% per year, payablesemi-annually in arrears on February 1 and August 1 of each year. The 2014 Notes will mature on February 1, 2034, unless earlier converted, redeemed, orrepurchased in accordance with the terms of the 2014 Notes.The initial conversion rate of the 2014 Notes is 17.8750 shares of our common stock, par value $0.001 per share, per $1,000 principal amount of 2014Notes (which is equivalent to an initial conversion price of approximately $55.94 per share). The conversion rate will be subject to adjustment upon theoccurrence of certain specified events including upon conversion in connection with a fundamental change, as defined in the indenture governing the 2014Notes or, subject to certain conditions, redemption of the 2014 Notes by us.Holders may surrender their 2014 Notes for conversion at any time prior to the stated maturity date. On or after February 6, 2018, and prior to February6, 2021, we may redeem any or all of the 2014 Notes in cash if the closing price of our common stock exceeds 130% of the conversion price for a specifiednumber of days, and on or after February 6, 2021, we may redeem any or all of the 2014 Notes in cash without any such condition. The redemption price ofthe 2014 Notes will equal 100% of the principal amount of the 2014 Notes plus accrued and unpaid interest. Holders may require us to repurchase all or aportion of their 2014 Notes on each of February 6, 2021, February 6, 2024, and February 6, 2029, at a repurchase price in cash equal to 100% of the principalamount of the 2014 Notes plus accrued and unpaid interest. If we undergo a fundamental change, as defined in the terms of the 2014 Notes, holders mayrequire us to repurchase the 2014 Notes in whole or in part for cash at a repurchase price equal to 100% of the principal amount of the 2014 Notes plusaccrued and unpaid interest.In February 2014, we received $195.2 million, net of underwriting discounts, from the issuance of the 2014 Notes and incurred approximately $1.1million in offering-related expenses. The underwriting discount of $6.0 million and the debt issuance costs of $1.1 million were recorded as offsets to theproceeds. The underwriting discount and offering-related expenses are being amortized to interest expense using the effective-interest rate method.2018 Senior Convertible Notes (2018 Notes)In March 2018, we entered into separate privately negotiated transactions with certain holders of our 2014 Notes to exchange $150.0 million inaggregate principal amount of the 2014 Notes for new convertible notes (2018 Notes). As of the closing of the 2018 Notes on March 12, 2018, the estimatedfair value was $145.5 million. The difference between the $150.0 million aggregate principal amount of the 2018 Notes and its fair value will be amortizedover the expected term of the 2018 Notes using the effective interest method through the first note holder put date of February 6, 2023.We accounted for the exchange transaction as an extinguishment of debt due to the significance of the change in value of the embedded conversionoption, resulting in a $0.1 million gain. The gain on extinguishment of debt was calculated as the difference between the reacquisition price (i.e., the fairvalue of the principal amount of 2018 Notes) and the net carrying value of the 2014 Notes exchanged net of unamortized debt discount and debt issuancecost write-offs.The 2018 Notes accrue interest at a rate of 2.75%, payable semi-annually in arrears on February 1 and August 1 of each year. The 2018 Notes willmature on February 1, 2034, unless earlier converted, redeemed, or repurchased in accordance with the terms of the indenture governing the 2018 Notes. Theinitial conversion rate of the 2018 Notes is 126.9438 shares of our common stock, par value $0.001 per share, per $1,000 principal amount of the 2018 Notes(which is equivalent to an initial conversion price of approximately $7.88 per share). The conversion rate will be subject to adjustment upon the occurrenceof certain specified events. Those certain specified events include Holders who convert their 2018 Notes voluntarily prior to our exercise of the Issuer'sConversion Option or in connection with a make-whole fundamental change prior to February 6, 2023, are entitled, under certain circumstances, to a make-whole premium in the form of an increase in the conversion rate determined by reference to a make-whole table set forth in the indenture governing the 2018Notes. Any time prior to the maturity of the 2018 Notes, we may convert the 2018 Notes, in whole but not in part, into cash, shares of our common stock, orcombination thereof, if the closing price of our common stock equals or exceeds 110% of the conversion price then in effect for a specified number of days(Issuer’s Conversion Option). On or after February 6, 2022, we may elect to redeem all or any portion of the772018 Notes at a redemption price equal to 100% of the accreted principal amount of the 2018 Notes on the redemption date of the 2018 Notes, plus accruedand unpaid interest.Holders of the 2018 Notes have the right, at their option, to require us to purchase all or a portion of the 2018 Notes (i) on February 6, 2023, February 6,2026, and February 6, 2029, or (ii) in the event of a fundamental change, as defined in the indenture governing the 2018 Notes, in each case, at a repurchaseprice equal to 100% of the accreted principal amount (i.e., up to 120% of the outstanding principal amount) of the 2018 Notes on the fundamental changerepurchase date, plus accrued and unpaid interest.Offering-related costs for the 2018 Notes were approximately $2.8 million. Offering-related costs of $2.2 million were capitalized as debt issuance costs,recorded as an offset to the carrying value of the 2018 Notes, and are being be amortized over the expected term of the 2018 Notes using the effective interestmethod through the first note holder put date of February 6, 2023. Offering-related costs of $0.6 million were accounted for as equity issuance costs, recordedas an offset to additional paid-in capital, and are not subject to amortization. Offering-related costs were allocated between debt and equity in the sameproportion as the allocation of the 2018 Notes between debt and equity.The carrying values of the components of the 2014 Notes and 2018 Notes are as follows (in thousands): December 31, 2018 2017 2.75% 2014 Notes due 2034 Principal amount $51,250 $201,250Unamortized debt discount (1,232) (5,087)Unamortized debt issuance cost (224) (925) $49,794 $195,238 2.75% 2018 Notes due 2034 Principal amount $149,999 $—Premium accretion 3,755 —Unamortized debt discount (29,558) —Unamortized debt issuance cost (1,932) — $122,264 $— $172,058 $195,2382018 Revolving Credit FacilityOn August 2, 2018, we entered into a revolving credit facility with Silicon Valley Bank (Revolving Credit Facility) in an aggregate principal amount ofup to the lesser of (i) $15.0 million (Maximum Amount) or (ii) the sum of (a) 85% of our eligible receivables and (b) 50% of our eligible inventory, in eachcase, subject to certain limitations (Borrowing Base), provided that the amount of eligible inventory that may be counted towards the Borrowing Base shallbe subject to a cap as set forth in the Revolving Credit Facility. Subject to the level of this borrowing base, we may make and repay borrowings from time totime until the maturity of the revolving credit facility. The borrowing base as of December 31, 2018 under the revolving credit facility was $12.3 million.There were no borrowings outstanding under the Revolving Credit Facility at December 31, 2018.The Revolving Credit Facility matures on August 2, 2020, and is collateralized by substantially all our property, other than intellectual property.Outstanding loans under the Revolving Credit Facility will bear interest, at the greater of (i) prime rate plus 0.50% or (ii) 5.50%. Interest on any outstandingloans is due and payable monthly and the principal balance is due at maturity though loans can be prepaid at any time without penalty. In addition, we pay aquarterly unused revolving line facility fee of 0.75% per annum on the average unused facility.Subject to certain exceptions, we must pay a prepayment fee equal to (i) 2.00% of the Maximum Amount if it prepays all advances and terminates theLoan Agreement prior to August 2, 2019, or (ii) 1.00% of the Maximum Amount if it prepays all advances and terminates the Loan Agreement on or afterAugust 2, 2019, and prior to the maturity date.78We incurred approximately $335,000 of debt issuance costs in connection with the facility, including $225,000 in commitment fees. Half of thecommitment fee was paid at the inception of the facility with the remainder due on the earliest of (i) August 2, 2019, (ii) the date on which we terminate theagreement or (iii) the occurrence and continuance of an event of default. Debt issuance costs were capitalized and are being amortized to interest expenseover the life of the Revolving Credit Facility.The Revolving Credit Facility contains customary affirmative and negative covenants which, unless waived by the bank, limit our ability to, amongother things, incur additional indebtedness, grant liens, make investments, repurchase stock, pay dividends, transfer assets, enter into affiliate transactions,undergo a change of control, or engage in merger and acquisition activity, including merging or consolidating with a third party. The Revolving CreditFacility also contains customary events of default, subject to customary cure periods for certain defaults, that include, among other things, non-paymentdefaults, covenant defaults, material judgment defaults, bankruptcy and insolvency defaults, cross-defaults to certain other material indebtedness, anddefaults due to inaccuracy of representation and warranties. Upon an event of default, the lender may declare all or a portion of the outstanding obligationspayable by us to be immediately due and payable and exercise other rights and remedies provided for under the Revolving Credit Facility. During theexistence of an event of default, interest on the obligations under the Revolving Credit Facility could be increased to 5.0% above the otherwise applicablerate of interest.We were in compliance with all the terms and conditions of the Revolving Credit Facility at December 31, 2018.797. Fair Value of Financial InstrumentsThe following tables summarize our cash and available-for-sale securities that were measured at fair value by significant investment category within thefair value hierarchy (in thousands): December 31, 2018 CarryingAmount Gross UnrealizedGain Gross UnrealizedLoss Fair Value Cash and CashEquivalents Short-TermMarketableSecuritiesAssets: Cash$17,685 $— $— $17,685 $17,685 $—Available-for-sale: Level I: Money market funds77,716 — — 77,716 77,716 — U.S. treasury securities— — — — — — Level II: U.S. government and agency securities— — — — — —Total$95,401 $— $— $95,401 $95,401 $— December 31, 2017 CarryingAmount Gross UnrealizedGain Gross UnrealizedLoss Fair Value Cash and CashEquivalents Short-TermMarketableSecuritiesAssets: Cash$20,129 $— $— $20,129 $20,129 $—Available-for-sale: Level I: Money market funds16,142 — — 16,142 16,142 — U.S. treasury securities497 — — 497 — 497 Level II: U.S. government and agency securities26,369 — (1) 26,368 21,785 4,583Total$63,137 $— $(1) $63,136 $58,056 $5,080There were no transfers between Level I and Level II measurements during the year ended December 31, 2018, and there were no changes in thevaluation techniques used.Based on an evaluation of securities that were in a loss position, we did not recognize any other-than-temporary impairment charges for the years endedDecember 31, 2018, 2017, and 2016. None of our investments have been in a continuous loss position for more than 12 months. We concluded that thedeclines in market value of our available-for-sale securities investment portfolio were temporary in nature and did not consider any of our investments to beother-than-temporarily impaired.Convertible NotesThe estimated fair value of the 2014 and 2018 Notes is based on a market approach and represents a Level II valuation. When determining the estimatedfair value of our long-term debt, we used a commonly accepted valuation methodology and market-based risk measurements that are indirectly observable,such as credit risk.80The following table summarizes the par value, carrying value and the estimated fair value of the 2014 and 2018 Notes at December 31, 2018 and 2017,respectively (in thousands): December 31, 2018 December 31, 2017 Par Value Carrying Value Fair Value Par Value Carrying Value Fair Value2014 Notes$51,250 $49,794 $43,665 $201,250 $195,238 $166,1622018 Notes149,999 122,264 171,843 — — —Total$201,249 $172,058 $215,508 $201,250 $195,238 $166,1628. Shareholders' EquityTax Benefit Preservation PlanOn August 1, 2017, the Tax Benefit Preservation Plan (Tax Plan) dated as of November 21, 2016 expired and all of the preferred share purchase rightsdistributed to the holders of our common stock pursuant to the Tax Plan expired.2018 Market OfferingOn December 14, 2018, we closed on our previously announced underwritten public offering of 9,372,500 shares our common stock, $0.001 par value.The common stock was sold at a price to the public of $6.75 per share, for aggregate gross proceeds of approximately $63.3 million, from our existing shelfregistration statement. Net proceeds from the offering were approximately $59.1 million after deducting underwriting discounts and commissions of $3.8million and the $0.4 million of estimated expenses of the offering. We intend to use the net proceeds of the offering for general corporate purposes, includingworking capital, capital expenditures and continued research and development with respect to products and technologies, and to fund possible investmentsin or acquisitions of complementary businesses, products, or technologies.2017 At-the-Market OfferingOn August 10, 2017, we sold 9,090,909 shares of our common stock, $0.001 par value per share, pursuant to an earlier Sales Agreement, for aggregategross proceeds of $30.0 million. Our aggregate net proceeds were approximately $28.8 million, after deducting related expenses, including commissions ofapproximately $0.7 million and issuance costs of approximately $0.5 million. These sales fully exhausted the shares that were available for sale under theSales Agreement. At December 31, 2018, we had reserved shares of common stock for future issuance under equity compensation plans as follows:(in 000's) Securities To BeIssued Upon ExerciseOf Options Securities To BeIssued Upon ReleaseOf Restricted Stockand PerformanceShare Units Number OfRemaining SecuritiesAvailable For FutureIssuance2009 Equity Incentive Plan 43 — —2011 Equity Incentive Plan 2,064 1,631 2,022DVS Sciences Inc. 2010 Equity Incentive Plan 38 — —2017 Inducement Award Plan 240 338 1,4222017 Employee Stock Purchase Plan — 698 2,385 1,969 4,1429. Stock-Based PlansOur board of directors sets the terms, conditions, and restrictions related to our ESPP and the grant of stock options, RSUs and performance-basedawards under our various stock-based plans. Our board of directors determines the number of awards to grant and also sets vesting criteria.81In general, RSUs vest on a quarterly basis over a period of four years from the date of grant at a rate of 25% on the first anniversary of the grant date andratably each quarter over the remaining 12 quarters, subject to the employees' continued employment.Incentive stock options and non-statutory stock options granted under the 2011 Plan have a term of no more than ten years from the date of grant andan exercise price of at least 100% of the fair market value of the underlying common stock on the date of grant. If a participant owns stock representing morethan 10% of the voting power of all classes of our stock on the grant date, an incentive stock option awarded to the participant will have a term of no morethan five years from the date of grant and an exercise price of at least 110% of the fair market value of the underlying common stock on the date of grant.Generally, options vest at a rate of either 25% on the first anniversary of the option grant date and ratably each month over the remaining period of 36months, or ratably each month over 48 months. We may grant options with different vesting terms from time to time.For performance-based share awards, our board of directors sets the performance objectives and other vesting provisions in determining the number ofshares or value of performance units and performance shares that will be paid out. Such payout will be a function of the extent to which performanceobjectives or other vesting provisions have been achieved.2011 Equity Incentive PlanOn January 28, 2011, our board of directors adopted the 2011 Equity Incentive Plan (the 2011 Plan) under which incentive stock options, non-statutorystock options, restricted stock units (RSUs), stock appreciation rights, performance units, and performance shares may be granted to our employees, directors,and consultants.2009 Equity Incentive Plan and 1999 Stock Option PlanOur 2009 Equity Incentive Plan (the 2009 Plan) terminated on the date the 2011 Plan was adopted. Options granted, or shares issued under the 2009Plan that were outstanding on the date the 2011 Plan became effective, remained subject to the terms of the 2009 Plan.2017 Inducement Award PlanOn January 5, 2017, we adopted the Fluidigm Corporation 2017 Inducement Award Plan (the “Inducement Plan”) and reserved 2 million shares of ourcommon stock for issuance pursuant to equity awards granted under the Inducement Plan. The Inducement Plan provides for the grant of equity-based awardsand its terms are substantially similar to the 2011 Plan. In accordance with Rule 5635(c)(4) of the Nasdaq Listing Rules, awards under the Inducement Planmay only be made to individuals not previously our employees or non-employee members of our board of directors (or following such individual's bona fideperiod of non-employment), as an inducement material to the individual's entry into employment with us or in connection with a merger or acquisition, to theextent permitted by Rule 5635(c)(3) of the Nasdaq Listing Rules.Valuation and Expense InformationWe use the Black-Scholes option-pricing model to estimate the fair value of stock options granted under our equity incentive plans. The weightedaverage assumptions used to estimate the fair value were as follows: Year Ended December 31, 2018 2017 2016Stock options: Weighted average expected volatility 68.4% 65.0% 43.4%Weighted average expected term 4.7 years 4.2 years 6.0 yearsWeighted average risk-free interest rate 2.7% 1.7% 1.4%Dividend yield — — —Weighted-average fair value per share $3.45 $2.97 $3.19 We determine the expected volatility based on our historical stock price volatility generally commensurate with the estimated expected term of thestock awards. The expected term of an award is based on historical forfeiture experience, exercise activity, and the terms and conditions of the stock awards.The risk-free interest rate is based on the U.S. Treasury yield in effect at the time of grant for zero coupon U.S. Treasury notes with maturities approximatelyequal to each grant’s expected82life. Each of these inputs is subjective and generally requires significant judgment by us. The fair value of the underlying common stock is also required tocompute the fair value calculation of options and ESPP. We account for forfeitures as they occur.We grant stock options at exercise prices not less than the fair value of our common stock at the date of grant. The fair value of RSUs granted toemployees was estimated on the date of grant by multiplying the number of shares granted by the fair market value of our common stock on the grant date.Activity under the 2011 Plan, the 2009 Plan, the 1999 Plan, and the Inducement Plan is as follows:Restricted Stock Units: Number of Units (in000's) Weighted-AverageGrant Date FairValue per UnitBalance at December 31, 2015 663 $32.48RSU granted 940 $7.06RSU released (328) $24.71RSU forfeited (210) $17.82Balance at December 31, 2016 1,065 $15.31RSU granted 916 $5.73RSU released (445) $15.57RSU forfeited (368) $13.11Balance at December 31, 2017 1,168 $8.55RSU granted 1,822 $5.98RSU released (945) $9.63RSU forfeited (233) $8.50Balance at December 31, 2018 1,812 $7.09The total intrinsic value of RSUs vested and released during the year ended December 31, 2018, 2017 and 2016 were approximately $6.8 million, $2.3million and $2.4 million, respectively. The intrinsic value of vested and released RSUs is calculated by multiplying the fair market value of our commonstock on the vesting date by the number of shares vested. As of December 31, 2018, the unrecognized compensation costs related to outstanding unvestedRSUs under our equity incentive plans were $9.7 million. We expect to recognize those costs over a weighted average period of 2.9 years.2018 Retention Bonus ProgramIncluded in the 2018 RSU activity are 379,593 of grants and releases related to a retention bonus program. As disclosed in our Current Report on Form8-K filed on February 10, 2017, we previously implemented a company-wide retention bonus incentive program in which our executive officers at the timealso participated. The bonus program provides for the payment of cash bonuses to program participants who were employees at the time the plan wasimplemented and who remain with Fluidigm through January 1, 2019. On September 18, 2018, the compensation committee of our board of directorsapproved an exchange program for our executive officers and for employees resident in the United States and Canada who are retention bonus programparticipants. In the exchange program, eligible participants could elect to surrender their right to receive a cash bonus in exchange for fully vested restrictedstock units issued under our 2011 Equity Incentive Plan on the terms described below. Among other reasons, our compensation committee adopted theexchange program to encourage employee stock ownership and to effectively manage cash resources. In connection with the bonus exchange program, each eligible employee could elect to exchange 25%, 50%, 75%, or 100% of the retention cash bonusotherwise payable under the terms of the program. Each employee participating in the exchange would receive a number of fully vested restricted stock unitsequal to the quotient, rounded up to the next whole number, determined by dividing the cash amount of the retention cash bonus that such eligible employeeelects to exchange by an amount equal to 85% of the lower of the closing prices of one share of our common stock on the commencement date of the83exchange offer or the closing date of the exchange offer. The exchange offer closed on November 5, 2018. The total value of the 379,593 shares of commonstock issued under this program was $2.8 million and is included in the total intrinsic value of RSUs released in 2018.Stock Options: Number of Options (000's) Weighted-AverageExercise Priceper Option Weighted-Average RemainingContractual Life (inYears) AggregateIntrinsic Value (1) in (000's)Balance at December 31, 2015 3,242 $20.45 2.2 Options granted 978 $7.44 Options exercised (57) $4.04 $310Option forfeited (603) $23.53 Balance at December 31, 2016 3,560 $16.62 6.8 Options granted 1,364 $5.61 Options exercised (25) $4.07 $42Option forfeited (2,735) $16.33 Balance at December 31, 2017 2,164 $10.41 6.6 Options granted 758 $6.05 Options exercised (40) $5.24 $81Option forfeited (497) $16.09 Balance at December 31, 2018 2,385 $7.56 7.8 $5,991Vested at December 31, 2018 1,026 $9.92 6.3 $2,111Expected to vest at December 31, 2018 1,359 $5.78 8.9 $3,879(1)Aggregate intrinsic value as of December 31, 2018 was calculated as the difference between the closing price per share of our common stock on the lasttrading day of 2018, which was $8.62, and the exercise price of the options, multiplied by the number of in-the-money options.As of December 31, 2018, the unrecognized compensation costs related to outstanding unvested options under our equity incentive plans were $4.2million. We expect to recognize those costs over a weighted average period of 2.6 years.2017 Stock Option ExchangeIncluded in the 2017 option activity above is the impact of our 2017 Stock Option Exchange Program. On August 23, 2017, we launched a one-timeStock Option Exchange Program (the Program), which eligible employees were able to exchange certain outstanding stock options (Eligible Options),whether vested or unvested, with an exercise price greater than $4.37 per share and greater than the closing price of a share of our common stock on theNasdaq Global Select Market on the expiration date of the exchange offer (the Offer), for restricted stock units or stock options (New Awards) covering alesser number of shares than were subject to the Eligible Options exchanged immediately before being canceled in the Offer. Non-employee members of ourboard of directors were not eligible to participate in the Program. The Program expired on September 20, 2017, with a closing price of $5.13 per share.Employees elected to surrender Eligible Options to purchase a total of 1,204,198 shares of our common stock. All surrendered options were canceledeffective as of the expiration date, and immediately thereafter, in exchange for such surrendered options, we issued (i) new options to purchase an aggregateof 399,117 shares of our common stock with an exercise price of $5.13; and (ii) restricted stock units representing 54,944 shares of our common stock, each,pursuant to the terms of the Offer and our 2011 Equity Incentive Plan. The new awards granted under the Program generally vest over three years.The Program did not result in a material incremental stock-based compensation expense because the fair value of the new awards was approximatelyequal to the fair value of the surrendered options immediately prior to the exchange date. The84original fair value of the surrendered options plus the incremental stock-based compensation expense is being recognized over the vesting periods of the NewAwards.Performance-based Awards2018 Performance Stock UnitsDuring the three months ended March 31, 2018, we granted 167,000 performance stock units to certain executive officers and senior level employees.The number of performance stock units ultimately earned is calculated based on the Total Shareholder Return (TSR) of our common stock as compared to theTSR of a defined group of peer companies during the performance period from January 1, 2018, to December 31, 2020. The percentage of performance stockunits that vest will depend on our relative position at the end of the performance period and can range from 0% to 200% of the number of units granted.Under FASB ASC Topic 718, the provisions of the performance stock unit awards related to TSR are considered a market condition, and the effects ofthat market condition should be reflected in the grant date fair value of the awards. We used a Monte Carlo simulation pricing model to incorporate themarket condition effects at our grant date with a fair value of $10.09 per unit.Activity under the 2018 performance stock units is as follows: Number of Units (in000's) Weighted-AverageGrant Date FairValue per UnitBalance at December 31, 2017 — $—RSU granted 167 10.09RSU released — —RSU forfeited (12) 10.09Balance at December 31, 2018 155 $10.09As of December 31, 2018, the unrecognized compensation costs related to these awards were $1.2 million. We expect to recognize those costs over aweighted average period of 2.2 years.2016 Performance-based Stock Options and Restricted Stock UnitsIn 2016, we granted 184,050 and 87,620 performance-based stock options and performance-based restricted stock units (each, a performance award),respectively, to executive officers and employees, which were accounted for as equity awards. The number of performance awards that ultimately vesteddepended on the achievement of certain performance criteria set by the compensation committee of our board of directors. The performance-based stockoptions had an exercise price per share of $7.10. We recognize stock-based compensation expense over the vesting period of the performance awards whenachievement of the performance criteria becomes probable. The performance criteria were not met, and the awards did not vest. We did not recognize anyexpense related to these performance awards in 2018, 2017 or 2016.2017 Employee Stock Purchase PlanOn August 1, 2017, our stockholders approved our 2017 Employee Stock Purchase Plan (ESPP) at the annual meeting of stockholders. Our ESPP offersU.S. and some non-U.S. employees the right to purchase shares of our common stock. Our ESPP has a six-month offering period, with a new periodcommencing on the first trading day on or after May 31 and November 30 of each year. Employees are eligible to participate through payroll deductions ofup to 10% of their compensation and may not purchase more than $25,000 of stock in any calendar year. The purchase price at which shares are sold underthe ESPP is 85% of the lower of the fair market value of a share of our common stock on the first day of the offering period or the last day of the offeringperiod. Our first ESPP offering period began on October 1, 2017 with a shorter offering period ending on November 30, 2017.85Stock-Based CompensationTotal stock-based compensation expense recognized was as follows (in thousands): For the Year Ended December 31, 2018 2017 20162018 Retention Bonus Program $2,809 $— $—Options and Restricted Stock Units 7,716 8,972 13,858Employee Stock Purchase Plan 498 120 —Total Share-Based Compensation $11,023 $9,092$13,85810. Income TaxesOur loss before income taxes consists of the following (in thousands): Year Ended December 31, 2018 2017 2016Domestic $(47,600) $(56,885) $(65,211)International (13,820) (6,914) (14,966)Loss before income taxes $(61,420) $(63,799) $(80,177)Significant components of our benefit for income taxes are as follows (in thousands): Year Ended December 31, 2018 2017 2016Current: Federal $(27) $— $—State (19) (17) (14)Foreign (32) (501) 286Total current tax (expense) benefit (78) (518) 272Deferred: State — — —Foreign 2,485 3,782 3,920Total deferred benefit 2,485 3,782 3,920Total benefit for income taxes $2,407 $3,264 $4,19286Reconciliation of income taxes at the statutory rate to the benefit from (provision for) income taxes recorded in the statements of operations is asfollows: Year Ended December 31, 2018 2017 2016Tax benefit at federal statutory rate 21.0 % 34.0 % 34.0 %State tax expense, net of federal benefit 2.3 5.5 2.2Foreign tax benefit (expense) (1.1) 0.4 (0.7)Change in valuation allowance (19.2) 39.2 (31.2)Federal research and development credit 1.5 1.9 1.3Unrecognized tax benefit (0.2) (0.6) (1.3)Impact of the Tax Act — (74.6) —Other, net (0.4) (0.7) 0.9Effective tax rate 3.9 % 5.1 % 5.2 %The Tax Act was enacted in December 2017. The Tax Act introduced a broad range of tax reform measures that significantly change the federal incometax laws. At December 31, 2017, we recorded the provisional income tax effects of the Tax Act under Accounting Standards Codification Topic 740, IncomeTaxes. Due to our having recorded a full valuation allowance against its U.S. federal and state deferred tax assets, there was no net impact on our taxprovision as a result of the remeasurement of U.S. deferred taxes using the relevant tax rate at which we expect them to reverse. The one-time transition tax onpost-1986 foreign unremitted earnings did not have a material impact to our effective tax rate as a result of generating net foreign deficit earnings. Inaccordance with Staff Accounting Bulletin (“SAB”) No. 118, we completed the accounting related to tax reform in the fourth quarter of 2018 and no materialadjustments to the provisional tax expense was required. We continue to monitor supplemental legislation and technical interpretations of the tax law thatmay cause the final impact from the Tax Act to differ from the amounts previously recorded.At December 31, 2017, we changed our permanent reinvestment assertion and will not permanently reinvest our foreign earnings outside the UnitedStates. The cash generated from some of our foreign subsidiaries may be used domestically to fund operations. Any domestic, foreign withholding tax andstate taxes that may be due upon future repatriation of earnings is not expected to be significant.Significant components of our deferred tax assets and liabilities are as follows (in thousands): December 31, 2018 2017Deferred tax assets: Net operating loss carryforwards $98,920 $91,701Reserves and accruals 7,167 3,927Depreciation and amortization 4,262 5,591Tax credit carryforwards 16,675 14,838Stock-based compensation 1,899 5,994Total gross deferred tax assets 128,923 122,051Valuation allowance on deferred tax assets (126,109) (119,228)Total deferred tax assets, net of valuation allowance 2,814 2,823Deferred tax liabilities: Fixed asset and intangibles (16,528) (18,912)Total deferred tax liabilities (16,528) (18,912)Net deferred tax liability $(13,714) $(16,089)We evaluate a number of factors to determine the realizability of our deferred tax assets. Recognition of deferred tax assets is appropriate whenrealization of these assets is more likely than not. Assessing the realizability of deferred tax assets is87dependent upon several factors including historical financial results. The net deferred tax assets have been partially offset by a valuation allowance becausewe have incurred losses since our inception. The valuation allowance increased by $6.9 million during 2018, decreased by $27.1 million during 2017 andincreased by $22.1 million during 2016, respectively. The change in valuation allowance during 2018 is mainly due to significant taxable losses and anincrease in tax attributes. The change in valuation allowance during 2017 is mainly due to the change in Federal statutory rate from 34% to 21%, offset by asignificant increase in the taxable loss in 2017.The valuation allowances of $126.1 million and $119.2 million as of December 31, 2018 and 2017, respectively, primarily relate to temporary taxdifferences, net operating losses and research and development credits generated in the current and prior years. We believe it is more likely than not that U.S.federal and state of California deferred tax assets relating to temporary differences, net operating losses and research and development credits are notrealizable. As such, full valuation allowances have been applied against the deferred tax assets relating to jurisdictions of the federal U.S. and the state ofCalifornia.A reconciliation of the beginning and ending amount of the valuation allowance for the years ended December 31, 2018, 2017, and 2016 is as follows(in thousands): Valuation AllowanceDecember 31, 2015$124,137Charges to earnings—Charges to other accounts22,148December 31, 2016146,285Charges to earnings830Charges to other accounts(27,887)December 31, 2017119,228Charges to earnings—Charges to other accounts6,880December 31, 2018$126,108As of December 31, 2018, we had net operating loss carryforwards for U.S. federal income tax purposes of $432.2 million, which expire beginning in2021, and U.S. federal research and development tax credits of $8.5 million, which expire in the years 2021 through 2039. As of December 31, 2018, we hadnet operating loss carryforwards for state income tax purposes of $170.3 million, which expire beginning in 2028 through 2039, and California research anddevelopment tax credits of $11.0 million, which do not expire. As of December 31, 2018, we had foreign net operating loss carryforwards of $1.9 million,which expire in the years 2019 through 2027.Utilization of the net operating loss carryforwards and credits may be subject to a substantial annual limitation due to the ownership change limitationsprovided by Section 382 of the Internal Revenue Code of 1986, as amended, and similar state provisions. The annual limitation may result in the expirationof net operating losses and credits before utilization. In 2015, we completed a Section 382 analysis for the period from our inception in May 1999 throughDecember 31, 2015, which excluded the net operating loss carryforwards for DVS prior to the acquisition and determined that an ownership change asdefined under Section 382 occurred in November 2001, which resulted in a reduction to our U.S. federal net operating losses by $1.2 million. In 2016, 2017and 2018, we continued the Section 382 analysis through December 31, 2018 and determined that an ownership change did not occur during the periods.88Uncertain Tax PositionsThe aggregate changes in the balance of our gross unrecognized tax benefits during 2018, 2017, and 2016 were as follows (in thousands):December 31, 2015$8,662Increases in balances related to tax positions taken during prior period46 Increases in balances related to tax positions taken during current period1,673 Decreases in balances related to tax positions taken during prior period(1,048)December 31, 20169,333Increases in balances related to tax positions taken during current period61Decreases in balances related to tax positions taken during prior period(2,077)December 31, 20177,317Increases in balances related to tax positions taken during current period255Decreases in balances related to tax positions taken during prior period(228)December 31, 2018$7,344Accrued interest and penalties related to unrecognized tax benefits were included in the income tax provision and are immaterial as of December 31,2018 and 2017.As of December 31, 2018, there are $0.4 million unrecognized tax benefits that, if recognized, would affect our effective tax rate. We do not anticipatethat our existing unrecognized tax benefits will significantly increase or decrease within the next 12 months.We file income tax returns in the United States, various states, and certain foreign jurisdictions. As a result of net operating loss carryforwards, all of ourtax years are open to federal and state examination in the United States. Tax years from 2013 are open to examination in various foreign countries.11. Employee Benefit PlansWe sponsor a 401(k) savings plan for our employees in the United States that stipulates that eligible employees may elect to contribute to the plan,subject to certain limitations, up to the lesser of 90% of eligible compensation or the maximum amount allowed by the U.S. Internal Revenue Service. In2015, we implemented a match formula of 100% up to $2,000 annually, following a 4-year vesting schedule. Employer matching contributions to the 401(k)plan for the years ended December 31, 2018, 2017, and 2016 were $0.4 million, $0.5 million, and $0.6 million, respectively.12. Information About Geographic AreasWe operate in one reporting segment that develops, manufacturers and commercializes tools for life sciences research. Our chief executive officermanages our operations and evaluates our financial performance on a consolidated basis. For purposes of allocating resources and evaluating regionalfinancial performance, our chief executive officer reviews separate sales information for the different regions of the world. Our general and administrativeexpenses and our research and development expenses are not allocated to any specific region. Most of our principal operations, other than manufacturing,and our decision-making functions are located at our corporate headquarters in the United States.A summary table of our total revenue by geographic areas of our customers and by product and services for the years ended December 31, 2018, 2017and 2016 is included in Note 3 to the Consolidated Financial Statements of this Form 10K.Sales to customers in the United States represented $48.1 million or 43%, of total revenues for the year ended December 31, 2018. Sales to customers inthe United States represented $45.8 million or 45% of total revenues for the year ended December 31, 2017, and $52.6 million or 50% for the year endedDecember 31, 2016.89Sales to customers in China represented $14.0 million or 12%, of total revenues for the year ended December 31, 2018. Sales to customers in Chinarepresented 11% or $11.1 million, of total revenues for each of the years ended December 31, 2017, and 2016 respectively.We had long-lived assets consisting of property, plant and equipment, net of accumulated depreciation, in the following geographic areas for each yearpresented (in thousands): December 31, 2018 2017United States $1,881 $3,500Singapore 3,748 5,167Canada 3,104 3,481EMEA 66 125Asia-Pacific 26 28Total $8,825 $12,30113. Commitments and ContingenciesOperating LeasesWe have entered into various long-term non-cancelable operating lease agreements for equipment and facilities expiring at various times throughMarch 2026. We lease office space under non-cancelable leases in the United States, Canada, Singapore, Japan, China, France and United Kingdom. Certainfacility leases also contain rent escalation clauses. Our lease payments are expensed on a straight-line basis over the life of the leases. Rental expense underoperating leases, net of amortization of lease incentives and sublease income, for the years ended December 31, 2018, 2017, and 2016 was $5.0 million, $4.7million, and $6.3 million, respectively.Future minimum lease payments and minimum sublease income under non-cancelable operating leases as of December 31, 2018 are as follows (inthousands):Fiscal Year Minimum LeasePayments Minimum SubleaseIncome Net Operating Leases2019 $4,184 $(520) $3,6642020 2,213 (164) 2,0492021 1,245 — 1,2452022 827 — 8272023 552 — 552 Thereafter 1,241 — 1,241Total $10,262 $(684) $9,578Other CommitmentsIn the normal course of business, we enter into various contractual and legally binding purchase commitments. As of December 31, 2018, thesecommitments were approximately $1.6 million.IndemnificationsFrom time to time, we have entered into indemnification provisions under certain of our agreements in the ordinary course of business, typically withbusiness partners, customers, and suppliers. Pursuant to these agreements, we may indemnify, hold harmless, and agree to reimburse the indemnified partieson a case-by-case basis for losses suffered or incurred by the indemnified parties in connection with any patent or other intellectual property infringementclaim by any third party with respect to our products. The term of these indemnification provisions is generally perpetual from the time of the execution ofthe agreement. The maximum potential amount of future payments we could be required to make under these indemnification provisions is typically notlimited to a specific amount. In addition, we have entered into indemnification agreements with our90officers, directors, and certain other employees. With certain exceptions, these agreements provide for indemnification for related expenses including, amongothers, attorneys' fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding.We incurred legal expenses between October 2015 and the third quarter of 2017 to defend claims by Thermo Fisher Scientific, Inc., (Thermo) againstone of our employees. In December 2015, Thermo Fisher Scientific, Inc., (Thermo) filed a complaint in the Circuit Court for the County of Kalamazoo,Michigan against one of its former employees who had recently been hired by us alleging, among other claims, misappropriation of proprietary informationand breach of contractual and fiduciary obligations to Thermo while such individual was still an employee of Thermo. In November 2016, Thermo amendedits complaint to add us as a party to the litigation, making various commercial and employment-related claims and seeking damages and injunctive relief. InJuly 2017, we entered into a settlement agreement with Thermo. Pursuant to the terms of the settlement agreement, we agreed to pay Thermo a one-timepayment of $3.0 million in exchange for a release and dismissal of all claims with prejudice upon payment of the settlement. In August 2017, we paid thesettlement of $3.0 million and received an insurance recovery payment of $1.0 million related to this matter.ContingenciesIn early March 2019, we experienced a ransomware attack that infiltrated and encrypted certain of our information technology systems, includingsystems containing critical business data. Immediately following the attack, actions were taken to recover the compromised systems and we believe we wereable to restore their operation without significant loss of business data. Based on the nature of the attack and its impact on our systems, we do not believeconfidential data was lost or disclosed, but we are continuing to monitor the situation. As of the date of this filing, we estimate the costs associated with theintrusion to be approximately $1.5 million and are seeking to recover these costs under an applicable insurance policy.From time to time, we may be subject to various legal proceedings and claims arising in the ordinary course of business. These include disputes andlawsuits related to intellectual property, mergers and acquisitions, licensing, contract law, tax, regulatory, distribution arrangements, employee relations andother matters. Periodically, we review the status of each matter and assess its potential financial exposure. If the potential loss from any claim or legalproceeding is considered probable and a range of possible losses can be estimated, we accrue a liability for the estimated loss. Legal proceedings are subjectto uncertainties, and the outcomes are difficult to predict. Because of such uncertainties, accruals are based only on the best information available at the time.As additional information becomes available, we continue to reassess the potential liability related to pending claims and litigation and may revise estimates.14. Quarterly Results of Operations (Unaudited)Selected quarterly results of operations for the years ended December 31, 2018 and 2017 are as follows (in thousands, except for per share amounts):2018 FirstQuarter SecondQuarter ThirdQuarter FourthQuarterTotal revenue $25,248 $26,428 $28,963 $32,325Net loss $(13,247) $(16,241) $(14,750) $(14,775)Net loss per share, basic and diluted $(0.34) $(0.42) $(0.38) $(0.36) 2017 FirstQuarter SecondQuarter ThirdQuarter FourthQuarterTotal revenue $25,533 $23,912 $24,747 $27,745Net loss $(17,202) $(16,933) $(15,944) $(10,456)Net loss per share, basic and diluted $(0.59) $(0.58) $(0.46) $(0.27)15. Subsequent EventFrom January 9, 2019 through February 27, 2019, we received notices from holders of the 2018 Notes electing to voluntarily convert approximately$138.1 million in aggregate principal amount pursuant to the terms of the Second Supplemental Indenture dated March 6, 2018, between us and U.S. BankNational Association (Trustee) to the Indenture dated91as of February 14, 2014, between us and the Trustee. As a result of such voluntary conversions, we have elected to fully satisfy our conversion obligations bydelivering approximately 17.9 million shares of our common stock to such holders and have retired approximately $138.1 million of the 2018 Notes. OnFebruary 27, we notified the Trustee of our intention to exercise our Issuer’s Conversion Option pursuant to the terms of the Second Supplemental Indenturewith respect to the remaining approximately $11.9 million in aggregate principal amount of 2018 Notes. These bonds were converted into approximately 1.5million shares of our common stock and the bonds retired in March 2019.ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURENone.ITEM 9A. CONTROLS AND PROCEDURESEvaluation of Disclosure Controls and ProceduresOur management, with the participation of our Chief Executive Officer and our Chief Financial Officer, evaluated the effectiveness of our disclosurecontrols and procedures as of December 31, 2018. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under theExchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in thereports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rulesand forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to bedisclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management,including its principal executive and principal financial officers, as appropriate to allow timely decisions regarding required disclosure. Managementrecognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectivesand management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation ofour disclosure controls and procedures as of December 31, 2018, our Chief Executive Officer and Chief Financial Officer concluded that, as of such date, ourdisclosure controls and procedures were effective at the reasonable assurance level.Management’s Report on Internal Control Over Financial ReportingOur management is responsible for establishing and maintaining adequate internal control over financial reporting (as such term is defined in ExchangeAct Rule 13a-15(f) to provide reasonable assurance regarding the reliability of our financial reporting and the preparation of financial statements for externalpurposes in accordance with generally accepted accounting principles. Management assessed our internal control over financial reporting as of December 31,2018. Management based its assessment on criteria established in Internal Control—Integrated Framework issued by the Committee of SponsoringOrganizations of the Treadway Commission (2013 Framework). Based on that evaluation, our management concluded that our internal control over financialreporting was effective as of December 31, 2018.The effectiveness of our internal control over financial reporting as of December 31, 2018 has been audited by PricewaterhouseCoopers, LLP, anindependent registered public accounting firm, as stated in their report included in this Annual Report on Form 10-K.Changes in Internal Control Over Financial ReportingThere were no changes in our internal control over financial reporting that occurred during the three months ended December 31, 2018 that havematerially affected, or are reasonably likely to materially affect, our internal control over financial reporting.Inherent Limitations on the Effectiveness of ControlsControl systems, no matter how well conceived and operated, are designed to provide a reasonable, but not an absolute, level of assurance that theobjectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits ofcontrols must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absoluteassurance that all control issues and instances of fraud, if any, have been detected. Because of the inherent limitations in any control system, misstatementsdue to error or fraud may occur and not be detected. 92ITEM 9B. OTHER INFORMATIONNot applicable.93PART IIIITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCEThe information called for by this item will be set forth in our Proxy Statement for the Annual Meeting of Stockholders to be filed with the SEC within120 days of the fiscal year ended December 31, 2018 and is incorporated herein by reference.Our board of directors has adopted a Code of Ethics and Conduct that applies to all of our employees, officers and directors, including our ChiefExecutive Officer, Chief Financial Officer and other executive and senior financial officers. The full text of our code of business conduct and ethics is postedon the investor relations page on our website which is located at www.fluidigm.com. We will post any amendments to our code of business conduct andethics, or waivers of its requirements, on our website.ITEM 11. EXECUTIVE COMPENSATIONThe information called for by this item will be set forth in our Proxy Statement and is incorporated herein by reference.ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERSThe information, if any, required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCEThe information, if any, required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.ITEM 14. PRINCIPAL ACCOUNTING FEES AND SERVICESThe information required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.94PART IVITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES1. Financial Statements. See “Index to Consolidated Financial Statements” in Part II, Item 8 of this Form 10-K.2. Financial Statement schedule. See “Index to Consolidated Financial Statements” in Part II, Item 8 of this Form 10-K.3. Exhibits. The exhibits listed in the accompanying Index to Exhibits are filed herewith or are incorporated by reference to exhibits previously filed with theU.S. Securities and Exchange Commission.95SCHEDULE II—VALUATION AND QUALIFYING ACCOUNTS AND RESERVES In thousands Balance atBeginning ofPeriod Additions/Charged toExpense Deductions Balance atEnd ofPeriodYear ended December 31, 2018 Accounts receivable allowance $391 $162 $(427) $126Year ended December 31, 2017 Accounts receivable allowance $502 $24 $(135) $391Year ended December 31, 2016 Accounts receivable allowance $103 $484 $(85) $502 In thousands Balance atBeginning ofPeriod Additions/Charged toExpense Deductions Balance atEnd ofPeriodYear ended December 31, 2018 Warranty allowance $699 $1,573 $(1,409) $863Year ended December 31, 2017 Warranty allowance $1,023 $695 $(1,019) $699Year ended December 31, 2016 Warranty allowance $1,076 $885 $(938) $1,02396ITEM 16. FORM 10-K SUMMARYNone.INDEX TO EXHIBITSExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed2.1 Agreement and Plan of Merger dated January 28, 2014 by andamong Fluidigm Corporation, DVS Sciences, Inc., Dawid MergerSub, Inc. and Shareholder Representative Services LLC. 8-K 2.1 1/29/20143.1 Eighth Amended and Restated Certificate of Incorporation ofFluidigm Corporation filed on February 15, 2011. 10-K 3.1 3/28/20113.2 Amended and Restated Bylaws of Fluidigm Corporation effectiveas of February 9, 2011. 10-K 3.2 3/28/20113.3 Certificate of Designation of Rights, Preferences and Privileges ofSeries A Participating Preferred Stock. 8-K 3.1 11/22/20163.4 Certificate of Elimination of Series A Participating Preferred Stockof Fluidigm Corporation. 8-K 3.1 8/2/20174.1 Specimen Common Stock Certificate of Fluidigm Corporation. S-8 4.1 8/3/20174.2 Indenture, dated February 4, 2014, by and between FluidigmCorporation and U.S. Bank National Association. 8-K 4.1 2/4/20144.3 First Supplemental Indenture, dated February 4, 2014, by andbetween Fluidigm Corporation and U.S. Bank NationalAssociation. 8-K 4.2 2/4/20144.4 Form of Global Note (included in Exhibit 4.3). 8-K 4.3 2/4/20144.5 Tax Benefit Preservation Plan, dated as of November 21, 2016, byand between Fluidigm Corporation and Computershare Inc., asRights Agent. 8-K 4.1 11/22/20164.6 Second Supplemental Indenture, dated March 6, 2018, betweenFluidigm Corporation and U.S. Bank National Association. 8-K 4.2 3/6/20184.7 Form of Exchange Note (included in Exhibit 4.6). 8-K 4.3 3/6/201810.1 Form of Indemnification Agreement between FluidigmCorporation and its directors and officers. S-1/A 10.1 1/28/201110.2 Reserved. 10.3# 2009 Equity Incentive Plan of Fluidigm Corporation, as amended. S-1 10.3 12/3/201010.3A# Forms of agreements under the 2009 Equity Incentive Plan. S-1 10.3A 12/3/201010.4# 2011 Equity Incentive Plan of Fluidigm Corporation. S-1/A 10.4 1/28/201110.4A# Forms of agreements under the 2011 Equity Incentive Plan. S-1/A 10.4A 1/28/201110.4B# Amendments to the Fluidigm Corporation 2011 Equity IncentivePlan and 2009 Equity Incentive Plan and the DVS Sciences, Inc.2010 Equity Incentive Plan. 8-K 10.2 8/2/201710.4C# Forms of U.S. agreements under the 2011 Equity Incentive Plan. SC TO-I (d)(2) 8/23/201797ExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed10.4D Rules of the Fluidigm Corporation 2011 Equity Incentive Plan forRestricted Stock Unit Awards Granted to French Participants. SC TO-I (d)(3) 8/23/201710.4E Rules of the Fluidigm Corporation 2011 Equity Incentive Plan forOptions Granted to French Participants. SC TO-I (d)(4) 8/23/201710.4F UK Sub-plan to the Fluidigm Corporation 2011 Equity IncentivePlan. SC TO-I (d)(5) 8/23/201710.4G# Form of Restricted Stock Unit Agreement-Non-U.S. under the 2011Equity Incentive Plan. SC TO-I (d)(6) 8/23/201710.4H# Form of Stock Option Agreement-Non-U.S. under the 2011 EquityIncentive Plan. SC TO-I (d)(7) 8/23/201710.5† Second Amended and Restated License Agreement betweenCalifornia Institute of Technology and Fluidigm Corporation,effective as of May 1, 2004. S-1 10.5 12/3/201010.5A† First Addendum, effective as of March 29, 2007, to SecondAmended and Restated License Agreement between CaliforniaInstitute of Technology and Fluidigm Corporation effective as ofMay 1, 2004. S-1 10.5A 12/3/201010.6† Co-Exclusive License Agreement between President and Fellowsof Harvard College and Fluidigm Corporation effective as ofOctober 15, 2000. S-1 10.6 12/3/201010.6A† First Amendment to Co-Exclusive License Agreement betweenPresident and Fellows of Harvard College and FluidigmCorporation effective as of October 15, 2000. S-1 10.6A 12/3/201010.7† Co-Exclusive License Agreement between President and Fellowsof Harvard College and Fluidigm Corporation effective as ofOctober 15, 2000. S-1 10.7 12/3/201010.8† Co-Exclusive License Agreement between President and Fellowsof Harvard College and Fluidigm Corporation effective as ofOctober 15, 2000. S-1 10.8 12/3/201010.9† Letter Agreement between President and Fellows of HarvardCollege and Fluidigm Corporation dated December 22, 2004. S-1 10.9 12/3/201010.10# Fluidigm Corporation 2017 Inducement Award Plan and relatedform agreements. 8-K 10.1 1/11/201710.11 Loan and Security Agreement, dated as of August 2, 2018 by andbetween Fluidigm Corporation and Silicon Valley Bank. 8-K 10.1 8/2/201810.12 Reserved. 10.13# Amended and Restated Offer Letter to Steven C. McPhail, datedFebruary 28, 2017. 10-K 10.13 3/3/201710.14# Form of Amended and Restated Employment and SeveranceAgreement between Fluidigm Corporation and each of itsexecutive officers. 8-K 10.14 12/11/201210.15# Offer Letter to Stephen Christopher Linthwaite, dated July 14,2016. 10-Q 10.1 5/8/201810.16# Employment and Severance Agreement, effective as of August 1,2016, by and between Fluidigm Corporation and StephenChristopher Linthwaite. 10-Q 10.2 11/9/201610.17# Offer Letter to Vikram Jog dated January 29, 2008. S-1 10.17 12/3/201010.18# Offer Letter to Bradley A. Kreger dated February 13, 2018. Filed herewith 98ExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed10.19 Lease Agreement between ARE - San Francisco No. 17 LLC andFluidigm Corporation, dated September 14, 2010, as amendedSeptember 22, 2010. S-1/A 10.19 1/7/201110.19A Second Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated April 9,2013. 10-Q 10.19A 5/9/201310.19B Fourth Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated June 4,2014. 10-Q 10.3 8/4/201410.19C Fifth Amendment to Lease Agreement between ARE-San FranciscoNo. 17, LLC and Fluidigm Corporation, dated September 15,2014. 10-Q 10.2 11/6/201410.19D Sixth Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated December8, 2015. 8-K 10.1 12/14/201510.19E Seventh Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated March23,2017. 10-Q 10.1 5/9/201710.19F Eighth Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated August 2,2017. 8-K 10.1 8/3/201710.19G Ninth Amendment to Lease Agreement between ARE-SanFrancisco No. 17, LLC and Fluidigm Corporation, dated May 31,2018. 10-Q 10.2 8/8/201810.20 Tenancy for Flatted Factory Space in Singapore between JTCCorporation and Fluidigm Corporation dated July 27, 2005, asamended August 12, 2008 and May 31, 2010. S-1 10.20 12/3/201010.21 Offer of Tenancy for Facility Lease between Fluidigm SingaporePte. Ltd. and SBC Institutional Trust Services (Singapore) Limited,as trustee of Ascendas Real Estate Investment Trust dated October14, 2013. 10-K 10.21 3/12/201410.22 Offer of Tenancy for Lease of Additional Space at SingaporeFacility between Fluidigm Singapore Pte. Ltd. and HSBCInstitutional Trust Services (Singapore) Limited, as trustee ofAscendas Real Estate Investment Trust, dated April 2, 2015. 10-Q 10.1 8/10/201510.23† Office Lease by and among Rodick Equities Inc., Fluidigm CanadaInc., and Fluidigm Corporation, dated August 17, 2015. 10-Q 10.1 11/9/201510.24# Form of Award Agreement for purposes of the Retention Program. 8-K 10.1 2/10/201710.25# Form of Retention Bonus Exchange Letter. 8-K 10.1 9/20/201810.26# Executive Bonus Plan. 10-K 10.25 3/28/201110.27† License Agreement between MDS Analytical Technologies, abusiness unit of MDS INC., and DVS Sciences Inc., dated July 17,2008. 10-Q/A 10.3 9/15/201410.28† Sublicense Agreement between DVS Sciences Inc. and FluidigmCorporation, dated January 28, 2014. 10-Q/A 10.4 9/15/201410.29# Separation Agreement and Release between Gajus V. Worthingtonand Fluidigm Corporation dated October 19, 2016. 8-K 99.1 10/24/201610.30 2017 Employee Stock Purchase Plan. 8-K 10.1 8/2/201799ExhibitNumber Description Incorporatedby ReferenceFrom Form Incorporatedby ReferenceFrom ExhibitNumber Date Filed10.31 Sales Agreement, dated as of August 3, 2017, between FluidigmCorporation and Cowen and Company, LLC. 8-K 1.1 8/3/201710.32# Fluidigm Corporation Change of Control and Severance Plan. 8-K 10.1 8/23/201710.33# Endorsement Split-Dollar Life Insurance Agreement. 10-Q 10.5 11/7/201721.1 Subsidiaries of Fluidigm Corporation. 10-K 21.1 3/3/201723.1 Consent of PricewaterhouseCoopers LLP, Independent RegisteredPublic Accounting Firm. Filed herewith 24.1 Power of Attorney (contained in the signature page to thisForm 10-K). Filed herewith 31.1 Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 302 of the Sarbanes-Oxley Act of 2002 ofChief Executive Officer. Filed herewith 31.2 Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 302 of the Sarbanes-Oxley Act of 2002 ofChief Financial Officer. Filed herewith 32.1~ Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 906 of the Sarbanes-Oxley Act of 2002 ofChief Executive Officer. Filed herewith 32.2~ Certification Pursuant to 18 U.S.C. Section 1350, as AdoptedPursuant to Section 906 of the Sarbanes-Oxley Act of 2002 ofChief Executive Officer. Filed herewith 101.INS XBRL Instance Document - the instance document does notappear in the Interactive Data File because its XBRL tags areembedded within the Inline XBRL document. Filed herewith 101.SCH XBRL Taxonomy Extension Schema Document Filed herewith 101.CAL XBRL Taxonomy Extension Calculation Linkbase Document Filed herewith 101.DEF XBRL Taxonomy Extension Definition Linkbase Document Filed herewith 101.LAB XBRL Taxonomy Extension Label Document Filed herewith 101.PRE XBRL Taxonomy Extension Presentation Document Filed herewith # Management contracts or compensation plans or arrangements in which directors or executive officers are eligible to participate.† Portions of the exhibit have been omitted pursuant to an order granted by the Securities and Exchange Commission for confidential treatment.~ In accordance with Item 601(b)(32)(ii) of Regulation S-K and SEC Release No. 33-8238 and 34-47986, Final Rule: Management’s Reports on Internal Control Over FinancialReporting and Certification of Disclosure in Exchange Act Periodic Reports, the certifications furnished in Exhibits 32.1 and 32.2 hereto are deemed to accompany this Form 10-K and will not be deemed “filed” for purposes of Section 18 of the Exchange Act. Such certifications will not be deemed to be incorporated by reference into any filings under theSecurities Act or the Exchange Act, except to the extent that Fluidigm Corporation specifically incorporates it by reference.100SIGNATURESPursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on itsbehalf by the undersigned, thereunto duly authorized. FLUIDIGM CORPORATION Dated: March 18, 2019By: /s/ Stephen Christopher Linthwaite Stephen Christopher Linthwaite President and Chief Executive OfficerPOWER OF ATTORNEYKNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Stephen ChristopherLinthwaite and Vikram Jog, jointly and severally, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution,for him or her and in his or her name, place and stead, in any and all capacities, to sign this Form 10-K, and to file the same, with all exhibits thereto, andother documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power andauthority to do and perform each and every act and thing requisite or necessary to be done in and about the premises hereby ratifying and confirming all thatsaid attorneys-in-fact and agents, or his or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of theregistrant and in the capacities and on the dates indicated. Signature Title Date /s/ Stephen Christopher Linthwaite President and Chief Executive Officer (Principal ExecutiveOfficer); Director March 18, 2019Stephen Christopher Linthwaite /s/ Vikram Jog Chief Financial Officer (Principal Financial and AccountingOfficer) March 18, 2019Vikram Jog /s/ Samuel D. Colella Chairman of the Board of Directors March 18, 2019Samuel D. Colella /s/ Nicolas M. Barthelemy Director March 18, 2019Nicolas M. Barthelemy /s/ Gerhard F. Burbach Director March 18, 2019Gerhard F. Burbach /s/ Laura M. Clague Director March 18, 2019Laura M. Clague /s/ Patrick S. Jones Director March 18, 2019Patrick S. Jones /s/ Carlos V. Paya Director March 18, 2019Carlos V. Paya 101Exhibit 10.18February 13, 2018Bradley A. Kreger 8106 Polo Crosse AvenueVineyard, California 95829Dear Brad,I am pleased to offer you a position with Fluidigm Corporation (the “Company”) as a Senior Vice President, Product Operations, reporting directly to me. Other terms of employmentinclude:Start Date: March 26, 2018Compensation:You will receive an initial salary of $13,541.67 per pay period. We are on a semi-monthly pay schedule, with two pay periods per calendar month which generally fall on the 15th andthe last day of the month. This equates to a base compensation of $325,000.00 on an annual basis, less deductions as required by law, which will be paid in accordance with theCompany’s normal payroll procedures.Bonus Target:You will be eligible to participate in the Company’s Employee Bonus Plan. The bonus will be subject to achievement of performance objectives with the actual bonus amount to bedetermined by the Company in its discretion. To earn a bonus, you must remain employed with the Company through the date bonuses are actually paid. Your bonus target is 42.5%Equity Award:We will recommend to our Board of Directors or one of its committees after commencement of your employment with Fluidigm Corporation that you receive an on-hire grant of100,000 Stock Options and 50,000 Restricted Stock Units. Your grant will be subject to the approval of the Board, or its committee, and is subject to the terms of our equity incentiveplan, and our policies governing grants of equity incentive awards.Benefits:You are eligible to receive the Company’s standard benefits package which currently includes medical, dental, vision, life and disability insurance benefits. Benefits will be effective onyour date of hire. Additional benefits, as the Company may make generally available to its employees from time to time, will be made available to you. You will be entitled to accrueup to 3 weeks paid vacation each year and such paid holidays as the Company gives to its employees generally, in accordance with company policies.Workers’ Compensation Insurance:The Company provides a comprehensive workers’ compensation insurance program at no cost to employees. This program covers any injury or illness sustained in the course ofemployment that requires medical, surgical or hospital treatment. Insurance carrier: Preferred Employers Group - PO BOX 85838, San Diego, CA 92186, phone number (866) 472-9602.Confidentiality and Company Policies:It is important to protect our confidential information and proprietary material. Therefore, as a condition of employment you will be required to sign the Company’s standard At-WillEmployment, Confidential Information, Invention Assignment, And Arbitration Agreement.Background and reference checks: This offer is contingent upon successfully passing your background and reference checks.Employment Authorization:For purposes of federal immigration law, you will be required to provide to the Company documentary evidence of your identity and eligibility for employment in the United States.Such documentation must be provided to us within three (3) business days of your date of hire, or our employment relationship may be terminated.Other:This letter shall be interpreted under California law. You should be aware that your employment with the Company is for no specified period and constitutes “at will” employment. Asa result, you are free to resign at any time, for any reason or for no reason. Similarly, the Company is free to conclude its employment relationship with you at any time, with orwithout cause. In addition, the Company may change your compensation, duties, assignments, responsibilities, location of your position, or any other terms and conditions ofemployment at any time, to adjust to the changing needs of our dynamic Company.In the event of any dispute or claim relating to or arising out of our employment relationship, you and the Company agree that all such disputes shall be fully and finally resolved bybinding arbitration conducted by the Judicial Arbitration & Mediation Services (“JAMS”) in Santa Clara County California. The current JAMS employment arbitration rules &procedures can be found at http://www.jamsadr.com/rules-employment-arbitration/. The JAMS employment arbitration rules & procedures may, however, be amended by JAMS.) Youacknowledge that you are waiving your right to a jury trial.This offer expires on Feb 20, 2018, unless you accept prior to this date. To indicate your acceptance of the Company's offer, please sign and date this letter in the space provided belowand return it in the envelope provided to Rachael Papalia, Director of Talent Acquisition, 7000 Shoreline Court, Suite 100, South San Francisco, CA 94080. A copy is provided foryour records.This letter, along with the agreement relating to proprietary rights between you and the Company, set forth the terms of your employment with the Company and supersede any priorrepresentations or agreements, whether written or oral. This letter may not be modified or amended except by a written agreement, signed by the Company and by you.Our employees are committed to the success and growth of our business. At Fluidigm, we believe that our values are not just words on paper – they are a statement of our character. Fluidigmers should: Win as a team; Work hard and with passion; Be strong; Be aggressive; Do what you say you will do; Sweat the details; and Keep learning. We believe our valuesdefine who we are as a company and as employees of Fluidigm. We aspire to live by these values each day and work hard to exhibit these traits because these are the things that areworth believing. Brad, we look forward to you joining and being part of Fluidigm! I am certain we can build a great company together.Sincerely,/s/ Christopher LinthwaiteChristopher LinthwaitePresident & Chief Executive OfficerFluidigm CorporationACCEPTED AND AGREED TO: /s/ Bradley A. Kreger 2/17/2018 Bradley A. Kreger DateExhibit 23.1CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMWe hereby consent to the incorporation by reference in the Registration Statements on Form S-3 as amended (No. 333-216542), Form S-8 (Nos. 333-172206,333-180363, 333-187204, 333-202325, 333-209904, 333-215555, 333-219667, 333-222561, 333-229214), and Form S-3/S-8 (No. 333-194084) of FluidigmCorporation of our report dated March 18, 2019 relating to the financial statements and financial statement schedule, and the effectiveness of internal controlover financial reporting, which appears in this Form 10-K./s/ PricewaterhouseCoopers LLP San Jose, CaliforniaMarch 18, 2019Exhibit 31.1CERTIFICATION OF THE PRESIDENT AND CHIEF EXECUTIVE OFFICERPURSUANT TO SECURITIES EXCHANGE ACT RULES 13a-14(a) AND 15d-14(a),AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Stephen Christopher Linthwaite, certify that:1.I have reviewed this annual report on Form 10-K of Fluidigm Corporation;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary tomake the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the periodcovered by this report;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all materialrespects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as definedin Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f)and 15d-15(f)) for the registrant and have:a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under oursupervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known tous by others within those entities, particularly during the period in which this report is being prepared;b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under oursupervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financialstatements for external purposes in accordance with generally accepted accounting principles;c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation;andd. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s mostrecent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or isreasonably likely to materially affect, the registrant’s internal control over financial reporting; and5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, tothe registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internalcontrol over financial reporting.Date: March 18, 2019 By:/s/ Stephen Christopher Linthwaite Stephen Christopher Linthwaite President and Chief Executive OfficerExhibit 31.2CERTIFICATION OF THE CHIEF FINANCIAL OFFICERPURSUANT TO SECURITIES EXCHANGE ACT RULES 13a-14(a) AND 15d-14(a),AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Vikram Jog, certify that:1.I have reviewed this annual report on Form 10-K of Fluidigm Corporation;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary tomake the statements made, in light of the circumstances under which such statements were made, not misleading with respect tothe period covered by this report;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all materialrespects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in thisreport;4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as definedin Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules13a-15(f) and 15d-15(f)) for the registrant and have:a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under oursupervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known tous by others within those entities, particularly during the period in which this report is being prepared;b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designedunder our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation offinancial statements for external purposes in accordance with generally accepted accounting principles;c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusionsabout the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on suchevaluation; andd.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’smost recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or isreasonably likely to materially affect, the registrant’s internal control over financial reporting; and5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financialreporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing theequivalent functions):a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting whichare reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’sinternal control over financial reporting. Date: March 18, 2019 By:/s/ Vikram Jog Vikram Jog Chief Financial OfficerExhibit 32.1CERTIFICATION OF CHIEF EXECUTIVE OFFICERPURSUANT TO 18 U.S.C. SECTION 1350,AS ADOPTED PURSUANT TO SECTION 906OF THE SARBANES-OXLEY ACT OF 2002I, Stephen Christopher Linthwaite, the chief executive officer of Fluidigm Corporation (the “Company”), certify for the purposes of 18 U.S.C.Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,1.the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2018 (the “Report”), fully complies with the requirements ofSection 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and2.the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.Date: March 18, 2019By:/s/ Stephen Christopher Linthwaite Stephen Christopher Linthwaite President and Chief Executive Officer Exhibit 32.2CERTIFICATION OF CHIEF FINANCIAL OFFICERPURSUANT TO 18 U.S.C. SECTION 1350,AS ADOPTED PURSUANT TO SECTION 906OF THE SARBANES-OXLEY ACT OF 2002I, Vikram Jog, the chief financial officer of Fluidigm Corporation (the “Company”), certify for the purposes of 18 U.S.C. Section 1350, as adoptedpursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,1.the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2018 (the “Report”), fully complies with the requirements ofSection 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and2.the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.Date: March 18, 2019By:/s/ Vikram Jog Vikram Jog Chief Financial Officer 

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