UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-K
x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the fiscal year ended December 31, 2018
OR
¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from to
Commission File Number 001-32335
___________________________
HALOZYME THERAPEUTICS, INC.
( Exact
name
of
registrant
as
specified
in
its
charter
)
___________________________
(State
or
other
jurisdiction
of
incorporation
or
organization)
(I.R.S.
Employer
Identification
No.)
Delaware
88-0488686
11388 Sorrento Valley Road, San Diego, CA
(Address
of
principal
executive
offices)
92121
(Zip
Code)
(858) 794-8889
(Registrant’s
telephone
number,
including
area
code)
Securities registered under Section 12(b) of the Act:
Title of Each Class
Common Stock, $0.001 Par Value
Name of Each Exchange on Which Registered
The NASDAQ Stock Market, LLC
Securities registered under Section 12(g) of the Act:
None
Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. x
Yes ¨
No
Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. ¨
Yes x
No
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements
for the past 90 days. x
Yes ¨
No
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of
Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). x
Yes ¨
No
Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not contained herein, and will
not be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K. x
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or
emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and “emerging growth company” in
Rule 12b-2 of the Exchange Act.
Large accelerated filer
x
Accelerated filer
¨
Non-accelerated filer
¨
Smaller reporting company
¨
Emerging growth company
¨
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or
revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). ¨
Yes x
No
The aggregate market value of the voting and non-voting common equity held by non-affiliates of the registrant as of June 30, 2018 was approximately $2.1
billion based on the closing price on the NASDAQ Global Select Market reported for such date. Shares of common stock held by each officer and director and by
each person who is known to own 10% or more of the outstanding common stock have been excluded in that such persons may be deemed to be affiliates of the
registrant. This determination of affiliate status is not necessarily a conclusive determination for other purposes.
The number of outstanding shares of the registrant’s common stock, par value $0.001 per share, was 145,033,173 as of February 14, 2019 .
Portions of the registrant’s definitive Proxy Statement to be filed subsequent to the date hereof with the Securities and Exchange Commission pursuant to
Regulation 14A in connection with the registrant’s 2019 Annual Meeting of Stockholders are incorporated by reference into Part III of this Annual Report.
DOCUMENTS INCORPORATED BY REFERENCE
Business
Risk Factors
Unresolved Staff Comments
Properties
Legal Proceedings
Mine Safety Disclosures
HALOZYME THERAPEUTICS, INC.
INDEX
PART I
PART II
Market For Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
Selected Financial Data
Management’s Discussion and Analysis of Financial Condition and Results of Operations
Item 1.
Item 1A.
Item 1B.
Item 2.
Item 3.
Item 4.
Item 5.
Item 6.
Item 7.
Item 7A.
Quantitative and Qualitative Disclosures About Market Risk
Item 8.
Item 9.
Item 9A.
Item 9B.
Item 10.
Item 11.
Item 12.
Item 13.
Item 14.
Financial Statements and Supplementary Data
Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
Controls and Procedures
Other Information
Directors, Executive Officers and Corporate Governance
Executive Compensation
PART III
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
Certain Relationships and Related Transactions, and Director Independence
Principal Accounting Fees and Services
Item 15.
Item 16.
SIGNATURES
Exhibits, Financial Statement Schedules
Form 10-K Summary
PART IV
Page
1
15
29
30
30
30
31
33
34
45
45
45
46
48
48
49
49
50
50
50
54
55
This
Annual
Report
on
Form
10-K
contains
“forward-looking
statements”
within
the
meaning
of
the
“safe
harbor”
provisions
of
Section
21E
of
the
Securities
Exchange
Act
of
1934,
as
amended,
and
Section
27A
of
the
Securities
Act
of
1933,
as
amended.
All
statements,
other
than
statements
of
historical
fact,
included
herein,
including
without
limitation
those
regarding
our
future
product
development
and
regulatory
events
and
goals,
product
collaborations,
our
business
intentions
and
financial
estimates
and
anticipated
results,
are
forward-looking
statements.
Words
such
as
“expect,”
“anticipate,”
“intend,”
“plan,”
“believe,”
“seek,”
“estimate,”
“think,”
“may,”
“could,”
“will,”
“would,”
“should,”
“continue,”
“potential,”
“likely,”
“opportunity”
and
similar
expressions
or
variations
of
such
words
are
intended
to
identify
forward-looking
statements,
but
are
not
the
exclusive
means
of
identifying
forward-looking
statements
in
this
Annual
Report.
Additionally,
statements
concerning
future
matters
such
as
the
development
or
regulatory
approval
of
new
products,
enhancements
of
existing
products
or
technologies,
third
party
performance
under
key
collaboration
agreements,
revenue
and
expense
levels
and
other
statements
regarding
matters
that
are
not
historical
are
forward-looking
statements.
Although
forward-looking
statements
in
this
Annual
Report
reflect
the
good
faith
judgment
of
our
management,
such
statements
can
only
be
based
on
facts
and
factors
currently
known
by
us.
Consequently,
forward-looking
statements
are
inherently
subject
to
risks
and
uncertainties
and
actual
results
and
outcomes
may
differ
materially
from
the
results
and
outcomes
discussed
in
or
anticipated
by
the
forward-looking
statements.
Factors
that
could
cause
or
contribute
to
such
differences
in
results
and
outcomes
include
without
limitation
those
discussed
under
the
heading
“Risk
Factors”
in
Part
I,
Item
1A
below,
as
well
as
those
discussed
elsewhere
in
this
Annual
Report.
Readers
are
urged
not
to
place
undue
reliance
on
these
forward-looking
statements,
which
speak
only
as
of
the
date
of
this
Annual
Report.
We
undertake
no
obligation
to
revise
or
update
any
forward-looking
statements
in
order
to
reflect
any
event
or
circumstance
that
may
arise
after
the
date
of
this
Annual
Report.
Readers
are
urged
to
carefully
review
and
consider
the
various
disclosures
made
in
this
Annual
Report,
which
attempt
to
advise
interested
parties
of
the
risks
and
factors
that
may
affect
our
business,
financial
condition,
results
of
operations
and
prospects.
References
to
“Halozyme,”
“the
Company,”
“we,”
“us,”
and
“our”
refer
to
Halozyme
Therapeutics,
Inc.
and
its
wholly
owned
subsidiary,
Halozyme,
Inc.,
and
Halozyme,
Inc.’s
wholly
owned
subsidiaries,
Halozyme
Holdings
Ltd.,
Halozyme
Royalty
LLC,
Halozyme
Switzerland
GmbH
and
Halozyme
Switzerland
Holdings
GmbH.
References
to
“Notes”
refer
to
the
Notes
to
Consolidated
Financial
Statements
included
herein
(refer
to
Part
II,
Item
8).
Item 1.
Business
Overview
PART I
Halozyme Therapeutics, Inc. is a biotechnology company focused on developing and commercializing novel oncology therapies. We are seeking to translate
our unique knowledge of the tumor microenvironment to create therapies that have the potential to improve cancer patient survival. Our research primarily focuses
on human enzymes that alter the extracellular matrix and tumor microenvironment. The extracellular matrix is a complex matrix of proteins and carbohydrates
surrounding the cell that provides structural support in tissues and orchestrates many important biological activities, including cell migration, signaling and
survival. Over many years, we have developed unique technology and scientific expertise enabling us to pursue this target-rich environment for the development of
therapies.
Our proprietary enzymes are used to facilitate the delivery of injected drugs and fluids, potentially enhancing the efficacy and the convenience of other drugs
or can be used to alter tissue structures for potential clinical benefit. We exploit our technology and expertise using a two pillar strategy that we believe enables us
to manage risk and cost by: (1) developing our own proprietary products in therapeutic areas with significant unmet medical needs, with a focus on oncology, and
(2) licensing our technology to biopharmaceutical companies to collaboratively develop products that combine our technology with the collaborators’ proprietary
compounds.
1
The majority of our approved product and product candidates are based on rHuPH20, our patented recombinant human hyaluronidase enzyme. rHuPH20 is
the active ingredient in our first commercially approved product, Hylenex® recombinant, and it works by temporarily breaking down hyaluronan (or HA), a
naturally occurring carbohydrate that is a major component of the extracellular matrix in tissues throughout the body such as skin and cartilage. We believe this
temporary degradation creates an opportunistic window for the improved subcutaneous delivery of injectable biologics, such as monoclonal antibodies and other
large therapeutic molecules, as well as small molecules and fluids. We refer to the application of rHuPH20 to facilitate the delivery of other drugs or fluids as our
ENHANZE ® Drug Delivery Technology (ENHANZE). We license the ENHANZE technology to form collaborations with biopharmaceutical companies that
develop or market drugs requiring or benefiting from injection via the subcutaneous route of administration.
We currently have ENHANZE collaborations with F. Hoffmann-La Roche, Ltd. and Hoffmann-La Roche, Inc. (Roche), Baxalta US Inc. and Baxalta GmbH
(now members of the Takeda group of companies, following the acquisition of Shire plc by Takeda Pharmaceutical Company Limited in January 2019) (Baxalta),
Pfizer Inc. (Pfizer), Janssen Biotech, Inc. (Janssen), AbbVie, Inc. (AbbVie), Eli Lilly and Company (Lilly), Bristol-Myers Squibb Company (BMS), Alexion
Pharma Holding (Alexion) and ARGENX BVBA (argenx). We receive royalties from two of these collaborations, including royalties from sales of one product
from the Baxalta collaboration and two products from the Roche collaboration. Future potential revenues from the sales and/or royalties of our approved products,
product candidates, and ENHANZE collaborations will depend on the ability of Halozyme and our collaborators to develop, manufacture, secure and maintain
regulatory approvals for approved products and product candidates and commercialize product candidates.
Our proprietary development pipeline consists primarily of pre-clinical and clinical stage product candidates in oncology. Our lead oncology program is
Pegvorhyaluronidase alfa (PVHA), also referred to as PEGylated recombinant human hyaluronidase (PEGPH20), a molecular entity we are developing in
combination with currently approved cancer therapies as a candidate for the systemic treatment of tumors that accumulate HA. We have demonstrated that when
HA accumulates in a tumor, it can cause increased pressure in the tumor, reducing blood flow into the tumor and with that, reduced access of cancer therapies to
the tumor. PEGPH20 has been demonstrated in animal models to work by temporarily degrading HA surrounding cancer cells resulting in reduced pressure and
increased blood flow to the tumor thereby enabling increased amounts of anticancer treatments administered concomitantly gaining access to the tumor. Through
our efforts and efforts of our partners and collaborators, we are currently in Phase 3 clinical testing for PEGPH20 with ABRAXANE® (nab-paclitaxel) and
gemcitabine in stage IV pancreatic ductal adenocarcinoma (PDA) (HALO 109-301), in Phase 1b clinical testing for PEGPH20 with KEYTRUDA®
(pembrolizumab) in non-small cell lung cancer (HALO 107-101), in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq® (atezolizumab) in patients with
previously treated metastatic PDA, in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq in patients with gastric cancer and in Phase 1b/2 clinical testing for
PEGPH20 with Tecentriq in patients with cholangiocarcinoma and gall bladder cancer (HALO 110-101/MATRIX).
Our principal offices and research facilities are located at 11388 Sorrento Valley Road, San Diego, California 92121. Our telephone number is (858) 794-
8889 and our e-mail address is info@halozyme.com
. Our website address is www.halozyme.com
.
Information found on, or accessible through, our website is not a
part of, and is not incorporated into, this Annual Report on Form 10-K. Our periodic and current reports that we filed with the SEC are available on our website at
www.halozyme.com
, free of charge, as soon as reasonably practicable after we have electronically filed such material with, or furnished them to, the SEC,
including our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and any amendments to those reports.
Technology
rHuPH20 can be applied as a drug delivery platform to increase dispersion and absorption of other injected drugs and fluids that are injected under the skin or
in the muscle thereby potentially enhancing efficacy or convenience. For example, rHuPH20 has been used to convert drugs that must be delivered intravenously
into subcutaneous injections or to reduce the number of subcutaneous injections needed for effective therapy. When ENHANZE Technology is applied
subcutaneously, the rHuPH20 acts locally and has a tissue half-life of less than 15 minutes. HA at the local site reconstitutes its normal density within a few days
and, therefore, we anticipate that any effect of rHuPH20 on the architecture of the subcutaneous space is temporary.
2
Additionally, we are expanding our scientific work to develop other enzymes and agents that target the extracellular matrix’s unique aspects, giving rise to
potentially new molecular entities with a particular focus on oncology. We are developing a PEGylated version of the rHuPH20 enzyme (PEGPH20), that lasts for
an extended period in the bloodstream (half-life of one to two days), and may therefore better target solid tumors that accumulate HA by degrading the surrounding
HA and reducing the interstitial fluid pressure within malignant tumors to allow better penetration by co-administered agents.
Strategy
During 2018, we continued our strategy of focusing on developing our oncology pipeline and expanding our collaborations for ENHANZE Technology. This
business model allows for revenue garnered from collaboration products to help fund our investment in PEGPH20 clinical development, with the goal of a future
product approval that will support sustained growth.
Key aspects of our corporate strategy include the following:
•
•
Focus on our oncology pipeline. We are currently developing PEGPH20, our investigational new drug candidate, in multiple different tumors
that accumulate high levels of HA. PEGPH20 is in Phase 3 development in stage IV PDA and multiple Phase 1b/2 studies for various tumor
types. Over time, it is our goal to study additional types of cancer and to advance this program toward regulatory approval and commercial
launch. In addition, we have a novel oncology preclinical asset.
Focus on our ENHANZE platform. We currently have nine collaborations with three current product approvals and additional product candidates
in development. We intend to work with our existing collaborators to expand our collaborations to add new targets and develop targets and
product candidates under the terms of the operative agreements. In addition, we will continue our efforts to enter into new collaborations to
further derive additional value from our proprietary technology.
3
Product and Product Candidates
We have one marketed proprietary product, three partnered products, one proprietary product candidate targeting several indications in various stages of
development, and one preclinical product candidate. The following table summarizes our proprietary product and product candidate as well as products and
product candidates under development with our collaborators:
4
Proprietary Pipeline
Hylenex Recombinant (hyaluronidase human injection)
Hylenex recombinant is a formulation of rHuPH20 that has received U.S. Food and Drug Administration (FDA) approval to facilitate subcutaneous fluid
administration for achieving hydration, to increase the dispersion and absorption of other injected drugs and, in subcutaneous urography, to improve resorption of
radiopaque agents. Hylenex recombinant is currently the number one prescribed branded hyaluronidase.
PEGPH20
We are developing PEGPH20 in combination with currently approved cancer therapies as a candidate for the systemic treatment of tumors that accumulate
HA. ‘PEG’ refers to the attachment of polyethylene glycol to rHuPH20, thereby creating PEGPH20. One of the novel properties of PEGPH20 is that it lasts for an
extended duration in the bloodstream and, therefore, can be administered systemically to maintain its therapeutic effect to treat disease.
Cancer malignancies, including pancreatic, lung, breast, gastric, and biliary tract cancers can accumulate high levels of HA and therefore we believe that
PEGPH20 has the potential to help patients with these types of cancer when used with certain currently approved cancer therapies. Among solid tumors, PDA has
been reported to be associated with one of the highest frequencies of HA accumulation. There are approximately 65,000 annual diagnoses of PDA in the United
States and the European Union, and we estimate that 35-40% have high levels of HA based on our companion diagnostic assay cutpoint.
5
The pathologic accumulation of HA, along with other matrix components, creates a unique microenvironment for the growth of tumor cells compared to
normal cells. We believe that degrading the HA component of the tumor microenvironment with PEGPH20 remodels the tumor microenvironment, resulting in
tumor growth inhibition in animal models. Removal of HA from the tumor microenvironment results in expansion of previously constricted blood vessels allowing
increased blood flow, potentially increasing the access of activated immune cells and factors in the blood into the tumor microenvironment. If PEGPH20 is
administered in conjunction with other anti-cancer therapies, the increase in blood flow may allow anti-cancer therapies to have greater access to the tumor, which
may enhance the treatment effect of therapeutic modalities like chemotherapies, monoclonal antibodies and other agents.
We are developing PEGPH20 as a targeted therapy, for patients who have tumors with high levels of HA. We have a collaboration with Ventana Medical
Systems Inc. (Ventana), a member of the Roche Group, to develop, and for Ventana to ultimately commercialize, a companion diagnostic assay for use with
PEGPH20. The companion diagnostic assay is being used to identify high levels of HA in tumor biopsies, and may be the first diagnostic to target tumor-
associated HA and possibly the first companion diagnostic assay in pancreatic cancer.
Pancreatic
cancer
indications:
Based on the results of Phase 1b and Phase 2 studies, HALO 109-201 and HALO 109-202, we embarked on a double blinded, placebo controlled study in
previously untreated pancreas cancer patients to test PEGPH20 plus gemcitabine and nab-paclitaxel (ABRAXANE ® ) versus gemcitabine and ABRAXANE alone.
HALO
109-301:
In March 2015, we met with the FDA to discuss the interim efficacy and safety data from HALO-202, and the proposed selection of eligible patients based on
a 50% cutpoint using the Ventana companion diagnostic. Based on the feedback from that meeting, we proceeded with HALO 109-301 (HALO-301), a Phase 3
multicenter randomized clinical trial evaluating PEGPH20 as a first-line therapy for patients with stage IV PDA, using a design allowing for potential marketing
application based on PFS (accelerated approval pathway) or OS. The study enrolled patients whose tumors accumulate high levels of HA measured using the
Ventana companion diagnostic test. The FDA provided feedback on the current companion diagnostic approach and confirmed that an approved investigational
device exemption (IDE) was required for the Phase 3 study.
In June 2015, we received scientific advice/protocol assistance from the European Medicines Agency (EMA) regarding our Phase 3 study. The EMA agreed
to the patient population, and the use of both PFS and OS as co-primary endpoints stating that OS is the preferred endpoint and that ultimate approval would
require an overall positive benefit:risk balance.
In March 2016, Ventana received approval for an IDE application from the FDA for our companion diagnostic test to enable patient selection in our Phase 3
Study HALO-301 of PEGPH20 in HA-High patients and we dosed the first patient in HALO-301. In January 2019, our independent Data Safety Monitoring
Committee met to review ongoing safety data from the trial and informed us the study should proceed as planned.
In November 2018, the FDA agreed to our request to change the primary endpoint of the HALO-301 study from two primary endpoints of PFS and OS to a
single primary endpoint of OS. As a result, a previously planned interim analysis, that was to be performed when the target number of PFS events was achieved,
will not be conducted. PFS will remain as a secondary endpoint, along with objective response rate. In January 2019, the FDA completed their review of the
submitted clinical study protocol amendment and statistical analysis plan with no additional questions or comments. Over 200 sites in 22 countries located in North
America, Europe, South America and Asia were initiated to participate in the HALO-301 study. The study was fully enrolled with approximately 500 patients by
the end of 2018. We project that the target number of 330 OS events for the final analysis will be achieved between August and November 2019.
SWOG
Study
S1313:
In October 2013, SWOG, a cancer research cooperative group of more than 4,000 researchers in over 500 institutions around the world, initiated a 144 patient
Phase 1b/2 randomized clinical trial in some of their study centers, examining PEGPH20 in combination with modified FOLFIRINOX chemotherapy compared to
modified FOLFIRINOX treatment alone in patients with stage IV PDA, irrespective of HA levels, referred to as an all-comer population. This study was funded by
the National Cancer
6
Institute. In March 2017, SWOG stopped enrollment in the Phase 1b/2 trial following a recommendation of SWOG’s independent Data Monitoring committee after
a preplanned futility analysis. In January 2018, SWOG presented final data of the all-comers population at the ASCO-GI conference. The median overall survival
was 7.7 months for the PEGPH20 arm vs. 14.4 months in the modified FOLFIRINOX alone arm. Also, increased GI-toxicities and substantially shorter median
treatment duration for modified FOLFIRINOX were reported for the PEGPH20 arm compared to the modified FOLFIRINOX alone arm. Collection of biopsy
samples from participating sites to potentially enable an HA biomarker subgroup analysis has been completed. Due to the limited number of samples available, it is
not known if the data will be interpretable. Our PEGPH20 studies and clinical collaborations in combination with agents other than modified FOLFIRINOX
continue unchanged.
Clinical
collaboration:
In October 2016, we announced that PEGPH20 will be included in a pancreatic cancer clinical trial initiative called Precision Promise, an initiative that aims
to change the current treatment approach to pancreatic cancer by offering options to patients based on the molecular profile of their tumor. This is being
accomplished through the Pancreatic Cancer Action Network leading a collaboration that brings together clinicians, researchers, and drug developers. Pancreatic
Cancer Action Network continues to work to finalize the trial design and protocol which may include a potential PEGPH20 trial arm or trial.
Other
indications
outside
of
pancreatic
cancer
:
HALO
107-101:
In November 2015, we initiated a Phase 1b study exploring the combination of PEGPH20 and KEYTRUDA®, an immuno-oncology agent in relapsed non-
small cell lung cancer (NSCLC) and gastric cancer. In December 2016, we identified a dose of PEGPH20, namely 2.2 ug/kg, to move into the dose expansion
phase of the study with KEYTRUDA in combination with PEGPH20. In September 2017, our standing Independent Data Monitoring Safety Committee met to
review ongoing safety data from the trial and informed us that the study should proceed with study protocol modifications to exclude patients at risk and increase
liver safety monitoring, after observing clinical and laboratory signs of hepato-biliary dysfunction. In April 2018, we informed participating sites to stop screening
for new patients in the gastric cancer cohort of the study as the overall enrollment goal has been reached. Patients already in screening prior to the notification date
were allowed to enter the study contingent of all eligibility criteria being met. Following the results of Merck’s KEYNOTE-189 study evaluating KEYTRUDA in
combination with chemotherapy as a first-line treatment, the standard of care in lung cancer is expected to change. As we are seeking to enroll second line immune
checkpoint inhibitor naïve patients, we have closed enrollment in the lung cohort of the study and investigators were given the option to continue treatment of
ongoing patients.
HALO 107-101 is an ongoing study with an open database and enrollment has ended in both the NSCLC and gastric cancer cohorts. In the NSCLC cohort we
enrolled 17 of the target 30 patients in the dose expansion cohort prior to closing enrollment. One patient is ongoing. Of the 13 currently evaluable patients, four
patients experienced a greater than 30% reduction in tumor volume as assessed by investigator sites. Two of these patients had a further scan confirming the greater
than 30% reduction was maintained. Of the four patients experiencing a greater than 30% reduction, three were PD-L1 negative, while data was unavailable for the
fourth. Discussions are ongoing with advisers and investigators regarding the data and any next steps.
In the gastric cancer cohort, we reached target enrollment of 34 patients in the dose finding and dose expansion cohort. Of the 26 currently evaluable patients,
we have seen one responder in a PD-L1 positive patient. This response rate does not meet our threshold to continue development of PEGPH20 in combination with
Keytruda alone in gastric cancer.
We continue to collect and receive data on both NSCLC and gastric patients. When the database is considered complete and locked, a Final Study Report will
be generated and data presented.
7
Ongoing
clinical
collaboration:
In November 2016, we entered into an agreement with Genentech, a member of the Roche Group, to collaborate on clinical studies to evaluate their cancer
immunotherapy Tecentriq, an anti-PD-L1 monoclonal antibody, in combination with PEGPH20, in up to eight different tumor types. Genentech initiated a Phase
1b/2 clinical trial in patients with previously treated metastatic PDA in July 2017 and a Phase 1b/2 clinical trial in patients with gastric cancer in October 2017, as
part of its Morpheus master protocol. In February 2019, Genentech closed enrollment in the gastric arm of the study and results will be reported when data is
available. We will supply PEGPH20 for the Genentech-funded studies. In October 2017, we initiated a Phase 1b/2 clinical trial to assess Tecentriq with PEGPH20
in patients with cholangiocarcinoma and gall bladder cancer (HALO 110-101/MATRIX). Genentech will supply Tecentriq for the Halozyme sponsored study.
Regulatory
The FDA has granted Fast Track designation for our program investigating PEGPH20 in combination with gemcitabine and nab-paclitaxel for the treatment
of patients with stage IV PDA to demonstrate an improvement in OS. The Fast Track designation process was developed by the FDA to facilitate the development
and expedite the review of drugs to treat serious or life-threatening diseases and address unmet medical needs.
The FDA has granted Orphan Drug designation for PEGPH20 for the treatment of pancreatic cancer. The FDA Office of Orphan Products Development’s
mission is to advance the evaluation and development of products (drugs, biologics, devices, or medical foods) that demonstrate promise for the diagnosis and/or
treatment of rare diseases or conditions. Similarly, the European Committee for Orphan Medicinal Products of the EMA designated PEGPH20 an orphan medicinal
product for the treatment of pancreatic cancer.
Other Pipeline Asset
PEG-ADA2:
PEGylated adenosine deaminase 2, or PEG-ADA2, is an immune checkpoint inhibitor that targets adenosine, which may accumulate to high
levels in the tumor microenvironment and has been linked to immunosuppression. We are currently in preclinical development with PEG-ADA2 and are exploring
potential collaboration or partnership interest in this program prior to making additional investments in the development of PEG-ADA2.
ENHANZE Collaborations
Roche Collaboration
In December 2006, we and Roche entered into a collaboration and license agreement under which Roche obtained a worldwide license to develop and
commercialize product combinations of rHuPH20 and up to thirteen Roche target compounds (the Roche Collaboration). Under this agreement, Roche elected a
total of eight targets, two of which are exclusive.
In September 2013, Roche launched a subcutaneous (SC) formulation of Herceptin (trastuzumab) (Herceptin SC) in Europe for the treatment of patients with
HER2-positive breast cancer followed by launches in additional countries. This formulation utilizes our ENHANZE technology and is administered in two to five
minutes, compared to 30 to 90 minutes with the standard intravenous form. Directed at the same target, Roche initiated a Phase 1 study of PERJETA ®
(pertuzumab) and Herceptin (trastuzumab) with ENHANZE in patients with early breast cancer in March 2016. In June 2018, Roche initiated a global Phase 3
study of a fixed-dose combination of PERJETA and Herceptin with ENHANZE in patients with HER2-positive early breast cancer. In July 2018, we announced
the FDA accepted a BLA from Genentech (a member of the Roche Group) for Herceptin SC in its FDA-approved breast cancer indications. Approval of the BLA
is expected in March 2019. In September 2018, we announced that Roche received approval from Health Canada for Herceptin SC for the treatment of patients
with HER2-positive breast cancer.
In June 2014, Roche launched MabThera SC in Europe for the treatment of patients with common forms of non-Hodgkin lymphoma (NHL) followed by
launches in additional countries. This formulation utilizes our ENHANZE technology and is administered in approximately five minutes compared to the
approximately 1.5 to 4 hour intravenous infusion. In May 2016, Roche announced that the EMA approved Mabthera SC to treat patients with chronic lymphocytic
leukemia (CLL). In June 2017, the FDA approved Genentech’s RITUXAN HYCELA™, a combination of rituximab and rHuPH20 (approved and marketed under
8
the MabThera SC brand in countries outside the U.S.), for CLL and two types of NHL, follicular lymphoma and diffuse large B-cell lymphoma.
In September 2017, we and Roche entered into an agreement providing Roche the right to develop and commercialize one additional exclusive target using
our ENHANZE technology. The upfront license payment may be followed by event-based payments subject to Roche’s achievement of specified development,
regulatory and sales-based milestones. In addition, Roche will pay royalties to us if products under the collaboration are commercialized.
In January 2018, Roche initiated a Phase 1 study of an undisclosed target with ENHANZE technology. In February 2019, Roche canceled development of the
undisclosed target following discontinuation of the proprietary program.
In October 2018, we entered into an agreement with Roche for the right to develop and commercialize one additional exclusive target and an option to select
two additional targets within four years using our ENHANZE technology. The upfront license payment may be followed by event-based payments subject to
Roche’s achievement of specified development, regulatory and sales-based milestones. In addition, Roche will pay royalties to us if products under the
collaboration are commercialized.
In December 2018, Roche initiated a Phase 1b/2 study in patients with non-small cell lung cancer for Tecentriq (atezolizumab) in combination with our
ENHANZE technology.
Baxalta Collaboration
In September 2007, we and Baxalta entered into a collaboration and license agreement under which Baxalta obtained a worldwide, exclusive license to
develop and commercialize product combinations of rHuPH20 with GAMMAGARD LIQUID (HYQVIA) (the Baxalta Collaboration). HYQVIA is indicated for
the treatment of primary immunodeficiency disorders associated with defects in the immune system.
In May 2013, the European Commission granted Baxalta marketing authorization in all EU Member States for the use of HYQVIA (solution for
subcutaneous use) as replacement therapy for adult patients with primary and secondary immunodeficiencies. Baxalta launched HYQVIA in the first EU country in
July 2013 and has continued to launch in additional countries.
In September 2014, HYQVIA was approved by the FDA for treatment of adult patients with primary immunodeficiency in the U.S. HYQVIA is the first
subcutaneous immune globulin (IG) treatment approved for adult primary immunodeficiency patients with a dosing regimen requiring only one infusion up to once
per month (every three to four weeks) and one injection site per infusion in most patients, to deliver a full therapeutic dose of IG. The FDA’s approval of HYQVIA
was a significant milestone for us as it represented the first U.S. approved BLA which utilizes our rHuPH20 platform.
In May 2016, Baxalta announced that HYQVIA received a marketing authorization from the European Commission for a pediatric indication, which was
launched in Europe to treat primary and certain secondary immunodeficiencies.
Pfizer Collaboration
In December 2012, we and Pfizer entered into a collaboration and license agreement, under which Pfizer has the worldwide license to develop and
commercialize products combining our rHuPH20 enzyme with Pfizer proprietary biologics directed to up to six targets in primary care and specialty care
indications. Targets may be selected on an exclusive or non-exclusive basis. Pfizer has elected five targets on an exclusive basis and returned two targets.
Janssen Collaboration
In December 2014, we and Janssen entered into a collaboration and license agreement, under which Janssen has the worldwide license to develop and
commercialize products combining our rHuPH20 enzyme with Janssen proprietary biologics directed to up to five targets. Targets may be selected on an exclusive
basis. Janssen has elected CD38 as the first target on an exclusive basis. In October 2017, Janssen initiated its first Phase 3 study of subcutaneous delivery of
DARZALEX ® (daratumumab), directed at CD38, using ENHANZE technology, in multiple myeloma patients. Janssen has initiated six Phase 3 studies, one Phase
2 study and one Phase 1 study of daratumumab combined with the ENHANZE technology in patients with amyloidosis, smoldering myeloma and multiple
myeloma.
9
AbbVie Collaboration
In June 2015, we and AbbVie entered into a collaboration and license agreement, under which AbbVie has the worldwide license to develop and
commercialize products combining our rHuPH20 enzyme with AbbVie proprietary biologics directed to up to nine targets. Targets may be selected on an exclusive
basis. AbbVie elected one target on an exclusive basis, TNF alpha, for which it has discontinued development and returned the target.
Lilly Collaboration
In December 2015, we and Lilly entered into a collaboration and license agreement, under which Lilly has the worldwide license to develop and
commercialize products combining our rHuPH20 enzyme with Lilly proprietary biologics directed to up to five targets. Targets may be selected on an exclusive
basis. Lilly has elected two targets on an exclusive basis and one target on a semi-exclusive basis. In August 2017, Lilly initiated a Phase 1 study of an
investigational new therapy in combination with rHuPH20.
BMS Collaboration
In September 2017, we and BMS entered into a collaboration and license agreement, which became effective in November 2017, under which BMS has the
worldwide license to develop and commercialize products combining our rHuPH20 enzyme with BMS immuno-oncology targets directed at up to eleven targets.
Targets may be selected on an exclusive basis, with the exception of one co-exclusive target. BMS has designated multiple immuno-oncology targets including
programmed death 1 (PD-1) and has an option to select additional targets within five years from the effective date. In October 2018, BMS dosed the first patient in
a Phase 1 study evaluating the safety, pharmacokinetics and pharmacodynamics of BMS-986179, an investigational anti-CD-73 antibody and ENHANZE
technology. BMS is currently in a Phase 1 study of OPDIVO® (nivolumab) with ENHANZE.
Alexion Collaboration
In December 2017, we and Alexion entered into a collaboration and license agreement, under which Alexion has the worldwide license to develop and
commercialize products combining our rHuPH20 enzyme with Alexion’s portfolio of products directed at up to four targets. Targets may be selected on an
exclusive basis. Alexion elected two targets on an exclusive basis, including a C5 complement inhibitor and has an option to select two additional targets within
five years from the effective date. In August 2018, Alexion initiated a Phase 1 trial to study a next-generation subcutaneous formulation of ALXN1210 with
ENHANZE technology.
argenx Collaboration
In February 2019, we entered into an agreement with argenx for the right to develop and commercialize one exclusive target, the human neonatal Fc receptor
FcRn, which includes argenx's lead asset efgartigimod (ARGX-113), and an option to select two additional targets using our ENHANZE technology.
For a further discussion of the collaboration agreements, refer to Note 2, Summary
of
Significant
Accounting
Policies
-
Revenues
under
Collaborative
Agreements.
Customers
The following table indicates the percentage of total revenues in excess of 10% with any single customer:
Roche
Baxalta
BMS
Alexion
Year Ended December 31,
2018
2017
2016
72%
7%
4%
3%
38%
7%
32%
13%
63%
12%
—
—
For additional information regarding our revenues from customers, refer to Note 2, Summary
of
Significant
Accounting
Policies
—
Concentrations
of
Credit
Risk,
Sources
of
Supply
and
Significant
Customer
s, to our consolidated financial statements.
10
Patents and Proprietary Rights
Patents and other proprietary rights are essential to our business. Our success will depend in part on our ability to obtain patent protection for our inventions,
to preserve our trade secrets and to operate without infringing the proprietary rights of third parties. Our strategy is to actively pursue patent protection in the U.S.
and certain foreign jurisdictions for technology that we believe to be proprietary to us and that offers us a potential competitive advantage. Our patent portfolio
includes 39 issued patents in the U.S., more than 390 issued patents in Europe and other countries in the world and more than 100 pending patent applications. In
general, patents have a term of 20 years from the application filing date or earlier claimed priority date. Our issued patents will expire between 2022 and 2033. We
have multiple patents and patent applications throughout the world pertaining to our recombinant human hyaluronidase and methods of use and manufacture,
including an issued U.S. patent which expires in 2027 and an issued European patent which expires in 2024, which we believe cover the products and product
candidates under our existing collaborations, Hylenex
recombinant and PEGPH20. In addition, we have, under prosecution throughout the world, multiple patent
applications that relate specifically to individual product candidates under development, the expiration of which can only be definitely determined upon maturation
into our issued patents. We believe our patent filings represent a barrier to entry for potential competitors looking to utilize these hyaluronidases.
In addition to patents, we rely on unpatented trade secrets, proprietary know-how and continuing technological innovation. We seek protection of these trade
secrets, proprietary know-how and innovation, in part, through confidentiality and proprietary information agreements. Our policy is to require our employees,
directors, consultants, advisors, collaborators, outside scientific collaborators and sponsored researchers, other advisors and other individuals and entities to
execute confidentiality agreements upon the start of employment, consulting or other contractual relationships with us. These agreements provide that all
confidential information developed or made known to the individual or entity during the course of the relationship is to be kept confidential and not disclosed to
third parties except in specific circumstances. In the case of employees and some other parties, the agreements provide that all inventions conceived by the
individual will be our exclusive property. Despite the use of these agreements and our efforts to protect our intellectual property, there will always be a risk of
unauthorized use or disclosure of information. Furthermore, our trade secrets may otherwise become known to, or be independently developed by, our competitors.
We also file trademark applications to protect the names of our products and product candidates. These applications may not mature to registration and may
be challenged by third parties. We are pursuing trademark protection in a number of different countries around the world. There can be no assurances that our
registered or unregistered trademarks or trade names will not infringe on rights of third parties or will be acceptable to regulatory agencies.
Research and Development Activities
Our research and development expenses consist primarily of costs associated with the development and manufacturing of our product candidates,
compensation and other expenses for research and development personnel, supplies and materials, costs for consultants and related contract research, clinical trials,
facility costs and amortization and depreciation. We charge all research and development expenses to operations as they are incurred. Our research and
development activities are primarily focused on the development of our various product candidates.
Due to the uncertainty in obtaining the FDA and other regulatory approvals, our reliance on third parties and competitive pressures, we are unable to estimate
with any certainty the additional costs we will incur in the continued development of our proprietary product candidates for commercialization. However, we
expect our research and development expenses for PEGPH20 to increase as our program advances into additional tumors and later stages of clinical development.
Manufacturing
We do not have our own manufacturing facility for our product and product candidates, or the capability to package our products. We have engaged third
parties to manufacture bulk rHuPH20, PEGPH20 and Hylenex
recombinant.
11
We have existing supply agreements with contract manufacturing organizations Avid Bioservices, Inc. (Avid) and Catalent Indiana LLC (formerly Cook
Pharmica LLC) (Catalent) to produce supplies of bulk rHuPH20. These manufacturers each produce bulk rHuPH20 under current Good Manufacturing Practices
(cGMP) for clinical and commercial uses. Catalent currently produces bulk rHuPH20 for use in Hylenex
recombinant, product candidates and collaboration product
candidates. Avid currently produces bulk rHuPH20 for use in collaboration products. We rely on their ability to successfully manufacture these batches according
to product specifications. In addition, we validated and qualified a new facility operated by Avid as a manufacturer of bulk rHuPH20 for use in the products and
product candidates under the ENHANZE collaborations. It is important for our business for Catalent and Avid to (i) retain their status as cGMP-approved
manufacturing facilities; (ii) successfully scale up bulk rHuPH20 production; and/or (iii) manufacture the bulk rHuPH20 required by us and our collaborators for
use in our proprietary and collaboration products and product candidates. In addition to supply obligations, Avid and Catalent will also provide support for data and
information used in the chemistry, manufacturing and controls sections for FDA and other regulatory filings.
We have a commercial manufacturing and supply agreement with Patheon Manufacturing Services, LLC (Patheon) under which Patheon will provide the
final fill and finishing steps in the production process of Hylenex
recombinant. Under our commercial services agreement with Patheon, Patheon has agreed to fill
and finish Hylenex
recombinant product for us until December 31, 2019, subject to further extensions in accordance with the terms of the agreement. In addition,
we scaled up our manufacturing of PEGPH20 with third party suppliers to support additional clinical trials, including the Phase 3 trial, and ultimately, if approved,
potential commercial supply.
Sales, Marketing and Distribution
Hylenex Recombinant
Our commercial activities currently focus on Hylenex
recombinant. We have a team of sales specialists that provide hospital and surgery center customers
with the information about Hylenex
recombinant and information needed to obtain formulary approval for, and support utilization of, Hylenex
recombinant. Our
commercial activities also include marketing and related services and commercial support services such as commercial operations, managed markets and
commercial analytics. We also employ third-party vendors, such as advertising agencies, market research firms and suppliers of marketing and other sales support
related services to assist with our commercial activities.
We sell Hylenex
recombinant in the U.S. to wholesale pharmaceutical distributors, who sell the product to hospitals and other end-user customers. We engage
Integrated Commercialization Solutions (ICS), a division of AmerisourceBergen Specialty Group, a subsidiary of AmerisourceBergen, to act as our exclusive
distributor for commercial shipment and distribution of Hylenex
recombinant to our customers in the United States. In addition to distribution services, ICS
provides us with other key services related to logistics, warehousing, returns and inventory management, contract administration and chargebacks processing and
accounts receivable management. In addition, we utilize third parties to perform various other services for us relating to regulatory monitoring, including call
center management, adverse event reporting, safety database management and other product maintenance services.
Competition
The pharmaceutical industry is characterized by rapidly advancing technologies, intense competition and a strong emphasis on proprietary therapeutics. We
face competition from a number of sources, some of which may target the same indications as our product or product candidates, including large pharmaceutical
companies, smaller pharmaceutical companies, biotechnology companies, academic institutions, government agencies and private and public research institutions,
many of which have greater financial resources, drug development experience, sales and marketing capabilities, including larger, well established sales forces,
manufacturing capabilities, experience in obtaining regulatory approvals for product candidates and other resources than us. We face competition not only in the
commercialization of Hylenex
recombinant, but also for the in-licensing or acquisition of additional product candidates, and the out-licensing of our ENHANZE
Technology. In addition, our collaborators face competition in the commercialization of the product candidates for which the collaborators seek marketing approval
from the FDA or other regulatory authorities.
12
Hylenex Recombinant
Hylenex
recombinant is currently the only FDA approved recombinant human hyaluronidase on the market. The competitors for Hylenex recombinant
include, but are not limited to, Valeant Pharmaceuticals International, Inc.’s product, Vitrase ® , an ovine (ram) hyaluronidase, and Amphastar Pharmaceuticals,
Inc.’s product, Amphadase ® , a bovine (bull) hyaluronidase. In addition, some commercial pharmacies compound hyaluronidase preparations for institutions and
physicians even though compounded preparations are not FDA approved products.
Government Regulations
The FDA and comparable regulatory agencies in foreign countries regulate the manufacture and sale of the pharmaceutical products that we have developed
or currently are developing. The FDA has established guidelines and safety standards that are applicable to the laboratory and preclinical evaluation and clinical
investigation of therapeutic products and stringent regulations that govern the manufacture and sale of these products. The process of obtaining regulatory approval
for a new therapeutic product usually requires a significant amount of time and substantial resources. The steps typically required before a product can be
introduced for human use include:
•
•
animal pharmacology studies to obtain preliminary information on the safety and efficacy of a drug; or
laboratory and preclinical evaluation in
vitro
and in
vivo
including extensive toxicology studies.
The results of these laboratory and preclinical studies may be submitted to the FDA as part of an IND application. The sponsor of an IND application may
commence human testing of the compound 30 days after submission of the IND, unless notified to the contrary by the FDA.
The clinical testing program for a new drug typically involves three phases:
•
•
•
Phase 1 investigations are generally conducted in healthy subjects (in certain instances, Phase 1 studies that determine the maximum tolerated dose and
initial safety of the product candidate are performed in patients with the disease);
Phase 2 studies are conducted in limited numbers of subjects with the disease or condition to be treated and are aimed at determining the most effective
dose and schedule of administration, evaluating both safety and whether the product demonstrates therapeutic effectiveness against the disease; and
Phase 3 studies involve large, well-controlled investigations in diseased subjects and are aimed at verifying the safety and effectiveness of the drug.
Data from all clinical studies, as well as all laboratory and preclinical studies and evidence of product quality, are typically submitted to the FDA in a new
drug application (NDA). The results of the preclinical and clinical testing of a biologic product candidate are submitted to the FDA in the form of a BLA, for
evaluation to determine whether the product candidate may be approved for commercial sale. In responding to a BLA or NDA, the FDA may grant marketing
approval or request additional information. If additional information is requested we may provide such information or withdraw our application. Although the
FDA’s requirements for clinical trials are well established and we believe that we have planned and conducted our clinical trials in accordance with applicable
regulations and guidelines, these requirements may be subject to change. Accordingly, we could be required to conduct additional trials beyond what we had
planned due to the FDA’s safety and/or efficacy concerns or due to differing interpretations of the meaning of our clinical data or a change in the therapeutic
landscape. (See Part I, Item 1A, Risk
Factors.
)
The FDA’s Center for Drug Evaluation and Research must approve an NDA and the FDA’s Center for Biologics Evaluation and Research must approve a
BLA for a drug before it may be marketed in the United States. If we begin to market our proposed products for commercial sale in the U.S., any manufacturing
operations that may be established in or outside the U.S. will also be subject to rigorous regulation, including compliance with cGMP. We also may be subject to
regulation under the Occupational Safety and Health Act, the Environmental Protection Act, the Toxic Substance Control Act, the Export Control Act and other
present and future laws of general application. In addition, the handling, care and use of laboratory animals are subject to the Guidelines for the Humane Use and
Care of Laboratory Animals published by the National Institutes of Health.
13
Regulatory obligations continue post-approval, and include the reporting of adverse events when a drug is utilized in the broader patient population.
Promotion and marketing of drugs is also strictly regulated, with penalties imposed for violations of FDA regulations, the Lanham Act and other federal and state
laws, including the federal anti-kickback statute.
We currently intend to continue to seek, directly or through our collaborators, approval to market our products and product candidates in foreign countries,
which may have regulatory processes that differ materially from those of the FDA. We anticipate that we will rely upon independent consultants to seek and gain
approvals to market our proposed products in foreign countries or may rely on other pharmaceutical or biotechnology companies to license our proposed products.
We cannot guarantee that approvals to market any of our proposed products can be obtained in any country. Approval to market a product in any one foreign
country does not necessarily indicate that approval can be obtained in other countries.
From time to time, legislation is drafted and introduced in Congress that could significantly change the statutory provisions governing the approval,
manufacturing and marketing of drug products. In addition, FDA regulations and guidance are often revised or reinterpreted by the agency or reviewing courts in
ways that may significantly affect our business and development of our product candidates and any products that we may commercialize. It is impossible to predict
whether additional legislative changes will be enacted, or FDA regulations, guidance or interpretations changed, or what the impact of any such changes may be.
Executive Officers of the Registrant
Information concerning our executive officers, including their names, ages and certain biographical information can be found in Part III, Item 10, Directors,
Executive
Officers
and
Corporate
Governance
. This information is incorporated by reference into Part I of this report.
Employees
As of February 14, 2019 , we had 281 full-time employees. None of our employees are unionized and we believe our employee relations to be good.
14
Item 1A.
Risk Factors
Risks Related To Our Business
We have generated only limited revenues from product sales to date; we have a history of net losses and negative cash flows, and we may never achieve or
maintain profitability.
Relative to expenses incurred in our operations, we have generated only limited revenues from product sales, royalties, licensing fees, milestone payments,
bulk rHuPH20 supply payments and research reimbursements to date and we may never generate sufficient revenues from future product sales, licensing fees and
milestone payments to offset expenses. Even if we ultimately do achieve significant revenues from product sales, royalties, licensing fees, research
reimbursements, bulk rHuPH20 supply payments and/or milestone payments, we expect to incur significant operating losses over the next few years and we may
never become profitable on an extended basis. Through December 31, 2018 , we have incurred aggregate net losses of $531.4 million .
If our product candidates do not receive and maintain regulatory approvals, or if approvals are not obtained in a timely manner, such failure or delay would
substantially impair our ability to generate revenues.
Approval from the FDA or equivalent health authorities is necessary to manufacture and market pharmaceutical products in the U.S. and the other countries
in which we anticipate doing business have similar requirements. The process for obtaining FDA and other regulatory approvals is extensive, time-consuming,
risky and costly, and there is no guarantee that the FDA or other regulatory bodies will approve any applications that may be filed with respect to any of our
product candidates, or that the timing of any such approval will be appropriate for the desired product launch schedule for a product candidate. We and our
collaborators attempt to provide guidance as to the timing for the filing and acceptance of such regulatory approvals, but such filings and approvals may not occur
when we or our collaborators expect, or at all. The FDA or other foreign regulatory agency may refuse or delay approval of our product candidates for failure to
collect sufficient clinical or animal safety data and require us or our collaborators to conduct additional clinical or animal safety studies which may cause lengthy
delays and increased costs to our programs. For example, the approval of Baxalta’s HYQVIA BLA in the U.S. was delayed until we and Baxalta provided
additional preclinical data sufficient to address concerns regarding non-neutralizing antibodies to rHuPH20 that were detected in the registration trial. Although
these antibodies have not been associated with any known adverse clinical effects, and the HYQVIA BLA was approved by the FDA in September 2014, we
cannot assure you that they will not arise and have an adverse impact on future development of products which include rHuPH20, future sales of Hylenex
recombinant, our ability to enter into collaborations, or be raised by the FDA or other health authorities in connection with testing or approval of products
including rHuPH20.
We and our collaborators may not be successful in obtaining approvals for any additional potential products in a timely manner, or at all. Refer to the risk
factor titled “ Our
proprietary
and
collaboration
product
candidates
or
companion
diagnostic
assays
may
not
receive
regulatory
approvals
or
their
development
may
be
delayed
for
a
variety
of
reasons,
including
delayed
or
unsuccessful
clinical
trials,
regulatory
requirements
or
safety
concerns
” for additional information
relating to the approval of product candidates.
Additionally, even with respect to products which have been approved for commercialization, in order to continue to manufacture and market pharmaceutical
products, we or our collaborators must maintain our regulatory approvals. If we or any of our collaborators are unsuccessful in maintaining our regulatory
approvals, our ability to generate revenues would be adversely affected.
We may need to raise additional capital in the future and there can be no assurance that we will be able to obtain such funds.
We may need to raise additional capital in the future to continue the development of our product candidates or for other current corporate purposes. Our
current cash reserves and expected revenues during the next few years will not be sufficient for us to continue the development of our proprietary product
candidates, to fund general operations and conduct our business at the level desired. In addition, if we engage in acquisitions of companies, products or
technologies in order to execute our business strategy, we may need to raise additional capital. We may raise additional capital in the future through one or more
financing vehicles that may be available to us including (i) the public offering of securities; (ii) new collaborative agreements; (iii) expansions or revisions to
existing collaborative relationships; (iv) private financings; (v) other equity or debt financings; and/or (vi) monetizing assets.
15
In view of our stage of development, business prospects, the nature of our capital structure and general market conditions, if we are required to raise
additional capital in the future, the additional financing may not be available on favorable terms, or at all. If additional capital is not available on favorable terms
when needed, we will be required to raise capital on adverse terms or significantly reduce operating expenses through the restructuring of our operations or deferral
of one or more product development programs. If we raise additional capital, a substantial number of additional shares may be issued, which may negatively affect
our stock price and these additional shares will dilute the ownership interest of our current investors.
Use of our product candidates or those of our collaborators could be associated with side effects or adverse events.
As with most pharmaceutical products, use of our product candidates or those of our collaborators could be associated with side effects or adverse events
which can vary in severity (from minor reactions to death) and frequency (infrequent or prevalent). Side effects or adverse events associated with the use of our
product candidates or those of our collaborators may be observed at any time, including in clinical trials or when a product is commercialized, and any such side
effects or adverse events may negatively affect our or our collaborators’ ability to obtain or maintain regulatory approval or market our product candidates. Side
effects such as toxicity or other safety issues associated with the use of our product candidates or those of our collaborators could require us or our collaborators to
perform additional studies or halt development or commercialization of these product candidates or expose us to product liability lawsuits which will harm our
business. We or our collaborators may be required by regulatory agencies to conduct additional animal or human studies regarding the safety and efficacy of our
pharmaceutical product candidates which we have not planned or anticipated. Furthermore, there can be no assurance that we or our collaborators will resolve any
issues related to any product related adverse events to the satisfaction of the FDA or any regulatory agency in a timely manner or ever, which could harm our
business, prospects and financial condition. For example, in April 2014, a clinical hold was placed on patient enrollment and dosing of PEGPH20 in Study HALO-
202 as a result of a possible difference in the TE event rate that had been observed at that time in the trial between the group of patients treated with PEGPH20
versus the group of patients treated without PEGPH20. The clinical hold was lifted by the FDA in June 2014, and we have completed Study HALO-202.
If our contract manufacturers are unable to manufacture and supply to us bulk rHuPH20 or other raw materials in the quantity and quality required by us
or our collaborators for use in our products and product candidates, our product development and commercialization efforts could be delayed or stopped and
our collaborations could be damaged.
We have existing supply agreements with contract manufacturing organizations Avid Bioservices, Inc. (Avid) and Catalent Indiana LLC (formerly Cook
Pharmica LLC) (Catalent) to produce bulk rHuPH20. These manufacturers each produce bulk rHuPH20 under cGMP for clinical uses. Catalent currently produces
bulk rHuPH20 for use in Hylenex recombinant, product candidates and collaboration product candidates. Avid currently produces bulk rHuPH20 for use in
collaboration products and collaboration product candidates. In addition to supply obligations, Avid and Catalent will also provide support for the chemistry,
manufacturing and controls sections for FDA and other regulatory filings. We rely on their ability to successfully manufacture these batches according to product
specifications. If either Avid or Catalent: (i) is unable to retain its status as an FDA approved manufacturing facility; (ii) is unable to otherwise successfully scale
up bulk rHuPH20 production to meet corporate or regulatory authority quality standards; or (iii) fails to manufacture and supply bulk rHuPH20 in the quantity and
quality required by us or our collaborators for use in our proprietary and collaboration products and product candidates for any other reason, our business will be
adversely affected. In addition, a significant change in such parties’ or other third party manufacturers’ business or financial condition could adversely affect their
abilities to fulfill their contractual obligations to us. We have not established, and may not be able to establish, favorable arrangements with additional bulk
rHuPH20 manufacturers and suppliers of the ingredients necessary to manufacture bulk rHuPH20 should the existing manufacturers and suppliers become
unavailable or in the event that our existing manufacturers and suppliers are unable to adequately perform their responsibilities. We have attempted to mitigate the
impact of a potential supply interruption through the establishment of excess bulk rHuPH20 inventory where possible, but there can be no assurances that this
safety stock will be maintained or that it will be sufficient to address any delays, interruptions or other problems experienced by Avid and/or Catalent. Any delays,
interruptions or other problems regarding the ability of Avid and/or Catalent to supply bulk rHuPH20 or the ability of other third party manufacturers, to supply
other raw materials or ingredients necessary to produce our products on a timely basis could: (i) cause the delay of clinical trials or otherwise delay or prevent the
regulatory approval of proprietary or collaboration product candidates; (ii) delay or prevent the effective commercialization of proprietary or collaboration
products; and/or (iii) cause us to breach contractual obligations to deliver bulk rHuPH20 to our collaborators.
16
Such delays would likely damage our relationship with our collaborators, and they would have a material adverse effect on royalties and thus our business and
financial condition.
If we or any party to a key collaboration agreement fail to perform material obligations under such agreement, or if a key collaboration agreement, is
terminated for any reason, our business could significantly suffer.
We have entered into multiple collaboration agreements under which we may receive significant future payments in the form of milestone payments, target
designation fees, maintenance fees and royalties. We are dependent on our collaborators to develop and commercialize product candidates subject to our
collaborations in order for us to realize any financial benefits from these collaborations. Our collaborators may not devote the attention and resources to such
efforts that we would ourselves, change their clinical development plans, promotional efforts or simultaneously develop and commercialize products in
competition to those products we have licensed to them. Any of these actions could not be visible to us immediately and could negatively impact the benefits and
revenue we receive from such collaboration. In addition, in the event that a party fails to perform under a key collaboration agreement, or if a key collaboration
agreement is terminated, the reduction in anticipated revenues could delay or suspend our product development activities for some of our product candidates, as
well as our commercialization efforts for some or all of our products. Specifically, the termination of a key collaboration agreement by one of our collaborators
could materially impact our ability to enter into additional collaboration agreements with new collaborators on favorable terms, if at all. In certain circumstances,
the termination of a key collaboration agreement would require us to revise our corporate strategy going forward and reevaluate the applications and value of our
technology.
Most of our current proprietary and collaboration products and product candidates rely on the rHuPH20 enzyme, and any adverse development regarding
rHuPH20 could substantially impact multiple areas of our business, including current and potential collaborations, as well as proprietary programs.
rHuPH20 is a key technological component of ENHANZE technology and our most advanced proprietary and collaboration products and product candidates,
including the current and future products and product candidates under our ENHANZE collaborations, our PEGPH20 program, and Hylenex
recombinant. If there
is an adverse development for rHuPH20 (e.g., an adverse regulatory determination relating to rHuPH20, if we are unable to obtain sufficient quantities of
rHuPH20, if we are unable to obtain or maintain material proprietary rights to rHuPH20 or if we discover negative characteristics of rHuPH20), multiple areas of
our business, including current and potential collaborations, as well as proprietary programs would be substantially impacted. For example, elevated anti-rHuPH20
antibody titers were detected in the registration trial for Baxalta’s HYQVIA product as well as in a former collaborator’s product in a Phase 2 clinical trial with
rHuPH20, but have not been associated, in either case, with any adverse events. We monitor for antibodies to rHuPH20 in our collaboration and proprietary
programs, and although we do not believe at this time that the incidence of non-neutralizing anti-rHuPH20 antibodies in either the HYQVIA program or the former
collaborator’s program will have a significant impact on our other proprietary and other collaboration product candidates, there can be no assurance that there will
not be other such occurrences in the foregoing programs or our other programs or that concerns regarding these antibodies will not also be raised by the FDA or
other health authorities in the future, which could result in delays or discontinuations of our development or commercialization activities or deter entry into
additional collaborations with third parties.
We routinely evaluate, and may modify, our business strategy and our strategic focus to only a few fields or applications of our technology which may
increase the risk for potential negative impact from adverse developments.
We routinely evaluate our business strategy, and may modify this strategy in the future in light of our assessment of unmet medical needs, growth potential,
resource requirements, regulatory issues, competition, risks and other factors. As a result of these strategic evaluations, we may focus our resources and efforts on
one or a few programs or fields and may suspend or reduce our efforts on other programs and fields. For example, in the third quarter of 2014, we decided to focus
our resources on advancing PEGPH20 and expanding utilization of our ENHANZE technology. While we believe these are applications with the greatest potential
value, we have reduced the diversification of our programs and increased our dependence on the success of the areas we are pursuing. By focusing on one or a few
areas, we increase the potential impact on us if one of those programs or product candidates does not successfully complete clinical trials, achieve commercial
acceptance or meet expectations regarding sales and revenue. Our decision to focus on one or a few programs may also reduce the value of programs that are no
longer within our
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principal strategic focus, which could impair our ability to pursue collaborations or other strategic alternatives for those programs we are not pursuing.
Our proprietary and collaboration product candidates or companion diagnostic assays may not receive regulatory approvals or their development may be
delayed for a variety of reasons, including delayed or unsuccessful clinical trials, regulatory requirements or safety concerns.
Clinical testing of pharmaceutical products is a long, expensive and uncertain process, and the failure or delay of a clinical trial can occur at any stage,
including the patient enrollment stage. Even if initial results of preclinical and nonclinical studies or clinical trial results are promising, we or our collaborators may
obtain different results in subsequent trials or studies that fail to show the desired levels of safety and efficacy, or we may not, or our collaborators may not, obtain
applicable regulatory approval for a variety of other reasons. Preclinical, nonclinical, and clinical trials for any of our proprietary or collaboration product
candidates or development of any collaboration companion diagnostic assays could be unsuccessful, which would delay or preclude regulatory approval and
commercialization of the product candidates or companion diagnostic assays. In the U.S. and other jurisdictions, regulatory approval can be delayed, limited or not
granted for many reasons, including, among others:
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during the course of clinical studies, the final data may differ from initial reported data, and clinical results may not meet prescribed endpoints for the
studies or otherwise provide sufficient data to support the efficacy of our product candidates;
clinical and nonclinical test results may reveal side effects, adverse events or unexpected safety issues associated with the use of our product
candidates; for example, in April 2014, a clinical hold was placed on patient enrollment and dosing of PEGPH20 in Study HALO-202 as a result of a
possible difference in the TE event rate that had been observed at that time in the trial between the group of patients treated with PEGPH20 versus
the group of patients treated without PEGPH20. The clinical hold was lifted by the FDA in June 2014, and Study HALO-202 is completed;
completion of clinical trials may be delayed for a variety of reasons including the amount of time it may take to identify and enroll patients with high
levels of HA in our target population, and the ability to procure drug supply required in clinical trial protocols;
clinical trial results may be negatively impacted if our companion diagnostic does not accurately identify patients most likely to respond to the
therapy, including the level of HA in patients;
third parties, such as contract research organizations, upon whom we rely to help conduct and manage our clinical trials may not perform
satisfactorily, fulfill their contractual obligations to us, meet expected deadlines or conduct our clinical trials in accordance with regulatory
requirements or our stated protocols;
regulatory review may not find a product candidate safe or effective enough to merit either continued testing or final approval;
regulatory review may not find that the data from preclinical testing and clinical trials justifies approval;
regulatory authorities may require that we change our studies or conduct additional studies which may significantly delay or make continued pursuit
of approval commercially unattractive;
a regulatory agency may reject our trial data or disagree with our interpretations of either clinical trial data or applicable regulations;
a regulatory agency may approve only a narrow use of our product or may require additional safety monitoring and reporting through Risk
Evaluation and Mitigation Strategies or conditions to assure safe use programs;
the cost of clinical trials required for product approval may be greater than what we originally anticipate, and we may decide to not pursue regulatory
approval for such a product;
a regulatory agency may not approve our manufacturing processes or facilities, or the processes or facilities of our collaborators, our contract
manufacturers or our raw material suppliers;
a regulatory agency may identify problems or other deficiencies in our existing manufacturing processes or facilities, or the existing processes or
facilities of our collaborators, our contract manufacturers or our raw material suppliers;
a regulatory agency may change its formal or informal approval requirements and policies, act contrary to previous guidance, adopt new regulations
or raise new issues or concerns late in the approval process; or
a product candidate may be approved only for indications that are narrow or under conditions that place the product at a competitive disadvantage,
which may limit the sales and marketing activities for such product candidate or otherwise adversely impact the commercial potential of a product.
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If a proprietary or collaboration product candidate or companion diagnostic assay is not approved in a timely fashion or obtained on commercially viable
terms, or if development of any product candidate or a companion diagnostic assay is terminated due to difficulties or delays encountered in the regulatory
approval process, it could have a material adverse impact on our business, and we would become more dependent on the development of other proprietary or
collaboration product candidates and/or our ability to successfully acquire other products and technologies. There can be no assurances that any proprietary or
collaboration product candidate or companion diagnostic assay will receive regulatory approval in a timely manner, or at all. There can be no assurance that we
will be able to gain clarity as to the FDA’s requirements or that the requirements may be satisfied in a commercially feasible way, in which case our ability to enter
into collaborations with third parties or explore other strategic alternatives to exploit this opportunity will be limited or may not be possible.
We anticipate that certain proprietary and collaboration products will be marketed, and perhaps manufactured, in foreign countries. The process of obtaining
regulatory approvals in foreign countries is subject to delay and failure for the reasons set forth above, as well as for reasons that vary from jurisdiction to
jurisdiction. The approval process varies among countries and jurisdictions and can involve additional testing. The time required to obtain approval may differ
from that required to obtain FDA approval. Foreign regulatory agencies may not provide approvals on a timely basis, if at all. Approval by the FDA does not
ensure approval by regulatory authorities in other countries or jurisdictions, and approval by one foreign regulatory authority does not ensure approval by
regulatory authorities in other foreign countries or jurisdictions or by the FDA.
Our third party collaborators are responsible for providing certain proprietary materials that are essential components of our collaboration products and
product candidates, and any failure to supply these materials could delay the development and commercialization efforts for these collaboration products
and product candidates and/or damage our collaborations.
Our development and commercialization collaborators are responsible for providing certain proprietary materials that are essential components of our
collaboration products and product candidates. For example, Roche is responsible for producing the Herceptin and MabThera required for its subcutaneous
products and Baxalta is responsible for producing the GAMMAGARD LIQUID for its product HYQVIA. If a collaborator, or any applicable third party service
provider of a collaborator, encounters difficulties in the manufacture, storage, delivery, fill, finish or packaging of the collaboration product or product candidate or
component of such product or product candidate, such difficulties could (i) cause the delay of clinical trials or otherwise delay or prevent the regulatory approval of
collaboration product candidates; and/or (ii) delay or prevent the effective commercialization of collaboration products. Such delays could have a material adverse
effect on our business and financial condition.
We rely on third parties to manufacture, prepare, fill, finish and package our products and product candidates, and if such third parties should fail to
perform, our commercialization and development efforts for our products and product candidates could be delayed or stopped.
We rely on third parties to manufacture, prepare, fill, finish, package, store and ship our products and product candidates on our behalf. If we are unable to
locate third parties to perform these functions on terms that are acceptable to us, or if the third parties we identify fail to perform their obligations, the progress of
clinical trials could be delayed or even suspended and the commercialization of approved product candidates could be delayed or prevented. In addition, we have
scaled up our manufacturing of PEGPH20 with third party suppliers to support additional clinical trials, including the Phase 3 trial, and ultimately, if approved,
potential commercial supply. If our contract manufacturers are unable to successfully manufacture and supply PEGPH20, the progress of our clinical trials could be
delayed or halted for a period of time.
If we are unable to sufficiently develop our sales, marketing and distribution capabilities or enter into successful agreements with third parties to perform
these functions, we will not be able to fully commercialize our products.
We may not be successful in marketing and promoting our approved product, Hylenex
recombinant, or any other products we develop or acquire in the future.
Our sales, marketing and distribution capabilities are very limited. In order to commercialize any products successfully, we must internally develop substantial
sales, marketing and distribution capabilities or establish collaborations or other arrangements with third parties to perform these services. We do not have
extensive experience in these areas, and we may not be able to establish adequate in-house sales, marketing and distribution capabilities or engage and effectively
manage relationships with third parties to perform any or all of such services. To the extent that we enter into co-promotion or other licensing arrangements, our
product revenues are likely to be lower than if we directly marketed and sold our products, and any revenues we receive will depend upon the efforts of third
parties, whose efforts may not meet our expectations or be successful.
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These third parties would be largely responsible for the speed and scope of sales and marketing efforts, and may not dedicate the resources necessary to maximize
product opportunities. Our ability to cause these third parties to increase the speed and scope of their efforts may also be limited. In addition, sales and marketing
efforts could be negatively impacted by the delay or failure to obtain additional supportive clinical trial data for our products. In some cases, third party
collaborators are responsible for conducting these additional clinical trials, and our ability to increase the efforts and resources allocated to these trials may be
limited.
If we or our collaborators fail to comply with regulatory requirements applicable to promotion, sale and manufacturing of approved products, regulatory
agencies may take action against us or them, which could significantly harm our business.
Any approved products, along with the manufacturing processes, post-approval clinical data, labeling, advertising and promotional activities for these
products, are subject to continual requirements and review by the FDA, state and foreign regulatory bodies. Regulatory authorities subject a marketed product, its
manufacturer and the manufacturing facilities to continual review and periodic inspections. We, our collaborators and our respective contractors, suppliers and
vendors, will be subject to ongoing regulatory requirements, including complying with regulations and laws regarding advertising, promotion and sales of drug
products, required submissions of safety and other post-market information and reports, registration requirements, cGMP regulations (including requirements
relating to quality control and quality assurance, as well as the corresponding maintenance of records and documentation), and the requirements regarding the
distribution of samples to physicians and recordkeeping requirements. Regulatory agencies may change existing requirements or adopt new requirements or
policies. We, our collaborators and our respective contractors, suppliers and vendors, may be slow to adapt or may not be able to adapt to these changes or new
requirements.
In particular, regulatory requirements applicable to pharmaceutical products make the substitution of suppliers and manufacturers costly and time consuming.
We have minimal internal manufacturing capabilities and are, and expect to be in the future, entirely dependent on contract manufacturers and suppliers for the
manufacture of our products and for their active and other ingredients. The disqualification of these manufacturers and suppliers through their failure to comply
with regulatory requirements could negatively impact our business because the delays and costs in obtaining and qualifying alternate suppliers (if such alternative
suppliers are available, which we cannot assure) could delay clinical trials or otherwise inhibit our ability to bring approved products to market, which would have
a material adverse effect on our business and financial condition. Likewise, if we, our collaborators and our respective contractors, suppliers and vendors involved
in sales and promotion of our products do not comply with applicable laws and regulations, for example off-label or false or misleading promotion, this could
materially harm our business and financial condition.
Failure to comply with regulatory requirements may result in any of the following:
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restrictions on our products or manufacturing processes;
warning letters;
withdrawal of the products from the market;
voluntary or mandatory recall;
fines;
suspension or withdrawal of regulatory approvals;
suspension or termination of any of our ongoing clinical trials;
refusal to permit the import or export of our products;
refusal to approve pending applications or supplements to approved applications that we submit;
product seizure;
injunctions; or
imposition of civil or criminal penalties.
We currently have significant debt and failure by us to fulfill our obligations under the applicable loan agreements may cause the repayment obligations to
accelerate.
In December 2015, our subsidiaries, Halozyme, Inc. (Halozyme) and Halozyme Royalty LLC (Halozyme Royalty) entered into a credit agreement (the Credit
Agreement) with BioPharma Credit Investments IV Sub, LP and Athyrium Opportunities II Acquisition LP (the Royalty-backed Lenders) pursuant to which we
borrowed $150 million through Halozyme Royalty (the Royalty-
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backed Loan). The Royalty-backed Loan will be repaid primarily from a specified percentage of the royalty payments we receive under our collaboration
agreements with Roche and Baxalta (the Royalty Payments).
The obligations of Halozyme Royalty under the Credit Agreement to repay the Royalty-backed Loan may be accelerated upon the occurrence of certain
events of default under the Credit Agreement, including but not limited to:
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if any payment of principal is not made within three days of when such payment is due and payable or otherwise made in accordance with the terms
of the Credit Agreement;
if any representations or warranties made in the Credit Agreement or any other transaction document proves to be incorrect or misleading in any
material respect when made;
if there occurs a default in the performance of affirmative and negative covenants set forth in the Credit Agreement or any other transaction
document;
the failure by either Baxalta or Roche to pay material amounts owed under our collaboration agreements because of an actual breach or default by us
under the collaboration agreements;
the voluntary or involuntary commencement of bankruptcy proceedings by either Halozyme or Halozyme Royalty and other insolvency related
defaults;
any materially adverse effect on the binding nature of any of the transaction documents or the collaboration agreements with Baxalta and Roche; or
Halozyme ceases to own, of record and beneficially, 100% of the equity interests in Halozyme Royalty.
The Credit Agreement also contains covenants applicable to Halozyme and Halozyme Royalty, including certain visitation, information and audits rights
granted to the collateral agent and the lenders and restrictions on the conduct of business, including continued compliance with the Baxalta and Roche
collaboration agreements and specified affirmative actions regarding the escrow account established to facilitate payment of Royalty Payments to the Royalty-
backed Lenders or other specified parties. The Credit Agreement also contains covenants solely applicable to Halozyme Royalty, including restrictions on
incurring indebtedness, creating or granting liens, making acquisitions and making specified restricted payments. These covenants could make it more difficult for
us to execute our business strategy.
In connection with the Royalty-backed Loan, Halozyme Royalty granted a first priority lien and security interest (subject only to permitted liens) in all of its
assets and all real, intangible and personal property, including all of its right, title and interest in and to the Royalty Payments.
In June 2016, we entered into a Loan and Security Agreement (the Loan Agreement) with Oxford Finance LLC (Oxford) and Silicon Valley Bank (SVB)
(collectively, the Lenders), providing a senior secured loan facility of up to an aggregate principal amount of $70 million, comprising a $55.0 million draw in June
2016 and an additional $15.0 million tranche, which we had the option to draw during the second quarter of 2017 and did not exercise. The initial proceeds were
partially used to pay the outstanding principal and final payment owed on our previous loan agreement with the Lenders. The remaining proceeds are to be used for
working capital and general business requirements. The Loan Agreement is secured by substantially all of the assets of the Company and its subsidiary, Halozyme,
Inc., except that the collateral does not include any equity interests in Halozyme, Inc., any intellectual property (including all licensing, collaboration and similar
agreements relating thereto), and certain other excluded assets. The Loan Agreement contains customary representations, warranties and covenants by us, which
covenants limit our ability to convey, sell, lease, transfer, assign or otherwise dispose of certain of our assets; engage in any business other than the businesses
currently engaged in by us or reasonably related thereto; liquidate or dissolve; make certain management changes; undergo certain change of control events; create,
incur, assume, or be liable with respect to certain indebtedness; grant certain liens; pay dividends and make certain other restricted payments; make certain
investments; make payments on any subordinated debt; and enter into transactions with any of our affiliates outside of the ordinary course of business or permit our
subsidiaries to do the same. In addition, subject to certain exceptions, we are required to maintain with SVB our primary deposit accounts, securities accounts and
commodities, and to do the same for our domestic subsidiary. Complying with these covenants may make it more difficult for us to successfully execute our
business strategy.
The Loan Agreement also contains customary indemnification obligations and customary events of default, including, among other things, our failure to
fulfill certain of our obligations under the Loan Agreement and the occurrence of a material adverse change which is defined as a material adverse change in our
business, operations or condition (financial or otherwise), a material
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impairment of the prospect of repayment of any portion of the loan, or a material impairment in the perfection or priority of the Lender’s lien in the collateral or in
the value of such collateral.
Our ability to make payments on our debt will depend on our future operating performance and ability to generate cash and may also depend on our ability to
obtain additional debt or equity financing. We will need to use cash to pay principal and interest on our debt, thereby reducing the funds available to fund our
research and development programs, strategic initiatives and working capital requirements. If we are unable to generate sufficient cash to service our debt
obligation, an event of default may occur. In the event of default by us under the Credit Agreement or the Loan Agreement, the lenders would be entitled to
exercise their remedies thereunder, including the right to accelerate the debt, upon which we may be required to repay all amounts then outstanding under the
Credit Agreement or the Loan Agreement which could harm our financial condition.
If proprietary or collaboration product candidates are approved for marketing but do not gain market acceptance, our business may suffer and we may not
be able to fund future operations.
Assuming that our proprietary or collaboration product candidates obtain the necessary regulatory approvals for commercial sale, a number of factors may
affect the market acceptance of these existing product candidates or any other products which are developed or acquired in the future, including, among others:
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the price of products relative to other therapies for the same or similar treatments;
the perception by patients, physicians and other members of the health care community of the effectiveness and safety of these products for their
prescribed treatments relative to other therapies for the same or similar treatments;
our ability to fund our sales and marketing efforts and the ability and willingness of our collaborators to fund sales and marketing efforts;
the degree to which the use of these products is restricted by the approved product label;
the effectiveness of our sales and marketing efforts and the effectiveness of the sales and marketing efforts of our collaborators;
the introduction of generic competitors; and
the extent to which reimbursement for our products and related treatments will be available from third party payors including government insurance
programs (Medicare and Medicaid) and private insurers.
If these products do not gain market acceptance, we may not be able to fund future operations, including the development or acquisition of new product
candidates and/or our sales and marketing efforts for our approved products, which would cause our business to suffer.
In addition, our proprietary and collaboration product candidates will be restricted to the labels approved by FDA and applicable regulatory bodies, and these
restrictions may limit the marketing and promotion of the ultimate products. If the approved labels are restrictive, the sales and marketing efforts for these products
may be negatively affected.
Developing and marketing pharmaceutical products for human use involves significant product liability risks for which we currently have limited insurance
coverage.
The testing, marketing and sale of pharmaceutical products involves the risk of product liability claims by consumers and other third parties. Although we
maintain product liability insurance coverage, product liability claims can be high in the pharmaceutical industry, and our insurance may not sufficiently cover our
actual liabilities. If product liability claims were to be made against us, it is possible that the liabilities may exceed the limits of our insurance policy, or our
insurance carriers may deny, or attempt to deny, coverage in certain instances. If a lawsuit against us is successful, then the lack or insufficiency of insurance
coverage could materially and adversely affect our business and financial condition. Furthermore, various distributors of pharmaceutical products require minimum
product liability insurance coverage before purchase or acceptance of products for distribution. Failure to satisfy these insurance requirements could impede our
ability to achieve broad distribution of our proposed products, and higher insurance requirements could impose additional costs on us. In addition, since many of
our collaboration product candidates include the pharmaceutical products of a third party, we run the risk that problems with the third party pharmaceutical product
will give rise to liability claims against us.
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Our inability to attract, hire and retain key management and scientific personnel could negatively affect our business.
Our success depends on the performance of key management and scientific employees with relevant experience. For example, in order to pursue our current
business strategy, we will need to recruit and retain personnel experienced in oncology drug development which is a highly competitive market for talent. We
depend substantially on our ability to hire, train, motivate and retain high quality personnel, especially our scientists and management team. Particularly in view of
the small number of employees on our staff to cover our numerous programs and key functions, if we are unable to retain existing personnel or identify or hire
additional personnel, we may not be able to research, develop, commercialize or market our products and product candidates as expected or on a timely basis and
we may not be able to adequately support current and future alliances with strategic collaborators. Our use of domestic and international third-party contractors,
consultants and staffing agencies also subjects us to potential co-employment liability claims.
Furthermore, if we were to lose key management personnel, we would likely lose some portion of our institutional knowledge and technical know-how,
potentially causing a substantial delay in one or more of our development programs until adequate replacement personnel could be hired and trained. We currently
have a severance policy applicable to all employees and a change in control policy applicable to senior executives.
We do not have key man life insurance policies on the lives of any of our employees.
Our operations might be interrupted by the occurrence of a natural disaster or other catastrophic event.
Our operations, including laboratories, offices and other research facilities, are located in four buildings in San Diego, California. In addition, we have a
satellite office in South San Francisco, California. We depend on our facilities and on our collaborators, contractors and vendors for the continued operation of our
business. Natural disasters or other catastrophic events, interruptions in the supply of natural resources, political and governmental changes, wildfires and other
fires, floods, explosions, actions of animal rights activists, earthquakes and civil unrest could disrupt our operations or those of our collaborators, contractors and
vendors. Even though we believe we carry commercially reasonable business interruption and liability insurance, and our contractors may carry liability insurance
that protect us in certain events, we may suffer losses as a result of business interruptions that exceed the coverage available under our and our contractors’
insurance policies or for which we or our contractors do not have coverage. Any natural disaster or catastrophic event could have a significant negative impact on
our operations and financial results. Moreover, any such event could delay our research and development programs.
If we or our collaborators do not achieve projected development, clinical, regulatory or sales goals in the timeframes we publicly announce or otherwise
expect, the commercialization of our products and the development of our product candidates may be delayed and, as a result, our stock price may decline,
and we may face lawsuits relating to such declines.
From time to time, we or our collaborators may publicly articulate the estimated timing for the accomplishment of certain scientific, clinical, regulatory and
other product development goals. The accomplishment of any goal is typically based on numerous assumptions, and the achievement of a particular goal may be
delayed for any number of reasons both within and outside of our control. If scientific, regulatory, strategic or other factors cause us to not meet a goal, regardless
of whether that goal has been publicly articulated or not, our stock price may decline rapidly. For example, the announcement in April 2014 of the temporary
halting of our Phase 2 clinical trial for PEGPH20 caused a rapid decline in our stock price. Stock price declines may also trigger direct or derivative shareholder
lawsuits. As with any litigation proceeding, the eventual outcome of any legal action is difficult to predict. If any such lawsuits occur, we will incur expenses in
connection with the defense of these lawsuits, and we may have to pay substantial damages or settlement costs in connection with any resolution thereof. Although
we have insurance coverage against which we may claim recovery against some of these expenses and costs, the amount of coverage may not be adequate to cover
the full amount or certain expenses and costs may be outside the scope of the policies we maintain. In the event of an adverse outcome or outcomes, our business
could be materially harmed from depletion of cash resources, negative impact on our reputation, or restrictions or changes to our governance or other processes that
may result from any final disposition of the lawsuit. Moreover, responding to and defending pending litigation significantly diverts management’s attention from
our operations.
In addition, the consistent failure to meet publicly announced milestones may erode the credibility of our management team with respect to future milestone
estimates.
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Future acquisitions could disrupt our business and harm our financial condition.
In order to augment our product pipeline or otherwise strengthen our business, we may decide to acquire additional businesses, products and technologies. As
we have limited experience in evaluating and completing acquisitions, our ability as an organization to make such acquisitions is unproven. Acquisitions could
require significant capital infusions and could involve many risks, including, but not limited to, the following:
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we may have to issue convertible debt or equity securities to complete an acquisition, which would dilute our stockholders and could adversely affect
the market price of our common stock;
an acquisition may negatively impact our results of operations because it may require us to amortize or write down amounts related to goodwill and
other intangible assets, or incur or assume substantial debt or liabilities, or it may cause adverse tax consequences, substantial depreciation or
deferred compensation charges;
we may encounter difficulties in assimilating and integrating the business, products, technologies, personnel or operations of companies that we
acquire;
certain acquisitions may impact our relationship with existing or potential collaborators who are competitive with the acquired business, products or
technologies;
acquisitions may require significant capital infusions and the acquired businesses, products or technologies may not generate sufficient value to
justify acquisition costs;
we may take on liabilities from the acquired company such as debt, legal liabilities or business risk which could be significant;
an acquisition may disrupt our ongoing business, divert resources, increase our expenses and distract our management;
acquisitions may involve the entry into a geographic or business market in which we have little or no prior experience; and
key personnel of an acquired company may decide not to work for us.
If any of these risks occurred, it could adversely affect our business, financial condition and operating results. There is no assurance that we will be able to
identify or consummate any future acquisitions on acceptable terms, or at all. If we do pursue any acquisitions, it is possible that we may not realize the anticipated
benefits from such acquisitions or that the market will not view such acquisitions positively.
Security breaches may disrupt our operations and harm our operating results.
We and our partners are subject to increasingly sophisticated attempts to gain unauthorized access to our information technology storage and access systems
and are devoting resources to protect against such intrusion. The wrongful use, theft, deliberate sabotage or any other type of security breach with respect to any of
our or any of our vendors and partners’ information technology storage and access systems could result in the disruption of our ability to use such systems or
disclosure or dissemination of our or our partners’ proprietary and confidential information that is electronically stored, including research or clinical data and
information regarding strategic initiatives, resulting in a material adverse impact on our business, operating results and financial condition. Our security and data
recovery measures may not be adequate to protect against computer viruses, break-ins, and similar disruptions from unauthorized tampering with our electronic
storage systems. Furthermore, any physical break-in or trespass of our facilities could result in the misappropriation, theft, sabotage or any other type of security
breach with respect to our proprietary and confidential information, including research or clinical data or damage to our research and development equipment and
assets. Such adverse effects could be material and irrevocable to our business, operating results and financial condition.
Risks Related To Ownership of Our Common Stock
Our stock price is subject to significant volatility.
We participate in a highly dynamic industry which often results in significant volatility in the market price of common stock irrespective of company
performance. The high and low sales prices of our common stock during the twelve months ended December 31, 2018 were $21.48 and $13.24 , respectively. We
expect our stock price to continue to be subject to significant volatility and, in addition to the other risks and uncertainties described elsewhere in this Annual
Report on Form 10-K and all other risks and uncertainties that are either not known to us at this time or which we deem to be immaterial, any of the following
factors may lead to a significant drop in our stock price:
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the presence of competitive products to those being developed by us;
failure (actual or perceived) of our collaborators to devote attention or resources to the development or commercialization of product candidates
licensed to such collaborator;
a dispute regarding our failure, or the failure of one of our third party collaborators, to comply with the terms of a collaboration agreement;
the termination, for any reason, of any of our collaboration agreements;
the sale of common stock by any significant stockholder, including, but not limited to, direct or indirect sales by members of management or our
Board of Directors;
the resignation, or other departure, of members of management or our Board of Directors;
general negative conditions in the healthcare industry;
general negative conditions in the financial markets;
the cost associated with obtaining regulatory approval for any of our proprietary or collaboration product candidates;
the failure, for any reason, to secure or defend our intellectual property position;
for those products that are not yet approved for commercial sale, the failure or delay of applicable regulatory bodies to approve such products;
identification of safety or tolerability issues;
failure of clinical trials to meet efficacy endpoints;
suspensions or delays in the conduct of clinical trials or securing of regulatory approvals;
adverse regulatory action with respect to our and our collaborators’ products and product candidates such as clinical holds, imposition of onerous
requirements for approval or product recalls;
our failure, or the failure of our third party collaborators, to successfully commercialize products approved by applicable regulatory bodies such as
the FDA;
our failure, or the failure of our third party collaborators, to generate product revenues anticipated by investors;
disruptions in our clinical or commercial supply chains, including disruptions caused by problems with a bulk rHuPH20 contract manufacturer or a
fill and finish manufacturer for any product or product candidate;
the sale of additional debt and/or equity securities by us;
our failure to obtain financing on acceptable terms or at all; or
a restructuring of our operations.
Future transactions where we raise capital may negatively affect our stock price.
We are currently a “Well-Known Seasoned Issuer” and may file automatic shelf registration statements at any time with the SEC. In February 2017, we filed
an automatic shelf registration statement on Form S-3 (Registration No. 333-216315) with the SEC. Sales of substantial amounts of shares of our common stock or
other securities under our current or future shelf registration statements could lower the market price of our common stock and impair our ability to raise capital
through the sale of equity securities.
Anti-takeover provisions in our charter documents and Delaware law may make an acquisition of us more difficult.
Anti-takeover provisions in our charter documents and Delaware law may make an acquisition of us more difficult. First, our board of directors is classified
into three classes of directors. Under Delaware law, directors of a corporation with a classified board may be removed only for cause unless the corporation’s
certificate of incorporation provides otherwise. Our amended and restated certificate of incorporation, as amended, does not provide otherwise. In addition, our
bylaws limit who may call special meetings of stockholders, permitting only stockholders holding at least 50% of our outstanding shares to call a special meeting
of stockholders. Our amended and restated certificate of incorporation, as amended, does not include a provision for cumulative voting for directors. Under
cumulative voting, a minority stockholder holding a sufficient percentage of a class of shares may be able to ensure the election of one or more directors. Finally,
our bylaws establish procedures, including advance notice procedures, with regard to the nomination of candidates for election as directors and stockholder
proposals.
These provisions may discourage potential takeover attempts, discourage bids for our common stock at a premium over market price or adversely affect the
market price of, and the voting and other rights of the holders of, our common stock. These
25
provisions could also discourage proxy contests and make it more difficult for stockholders to elect directors other than the candidates nominated by our board of
directors.
In addition, because we are incorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporation Law, which
may prohibit large stockholders from consummating a merger with, or acquisition of, us.
These provisions may deter an acquisition of us that might otherwise be attractive to stockholders.
Risks Related to Our Industry
Our products must receive regulatory approval before they can be sold, and compliance with the extensive government regulations is expensive and time
consuming and may result in the delay or cancellation of product sales, introductions or modifications.
Extensive industry regulation has had, and will continue to have, a significant impact on our business. All pharmaceutical companies, including ours, are
subject to extensive, complex, costly and evolving regulation by the health regulatory agencies including the FDA (and with respect to controlled drug substances,
the U.S. Drug Enforcement Administration (DEA)) and equivalent foreign regulatory agencies and state and local/regional government agencies. The Federal
Food, Drug and Cosmetic Act, the Controlled Substances Act and other domestic and foreign statutes and regulations govern or influence the testing,
manufacturing, packaging, labeling, storing, recordkeeping, safety, approval, advertising, promotion, sale and distribution of our products. We are dependent on
receiving FDA and other governmental approvals, including regulatory approvals in jurisdictions outside the United States, prior to manufacturing, marketing and
shipping our products. Consequently, there is always a risk that the FDA or other applicable governmental authorities, including those outside the United States,
will not approve our products or may impose onerous, costly and time-consuming requirements such as additional clinical or animal testing. Regulatory authorities
may require that we change our studies or conduct additional studies, which may significantly delay or make continued pursuit of approval commercially
unattractive. For example, the approval of Baxalta’s HYQVIA BLA was delayed by the FDA until we and Baxalta provided additional preclinical data sufficient to
address concerns regarding non-neutralizing antibodies to rHuPH20 that were detected in the registration trial. Although these antibodies have not been associated
with any known adverse clinical effects, and the HYQVIA BLA was approved by the FDA in September 2014, the FDA or other foreign regulatory agency may, at
any time, halt our and our collaborators’ development and commercialization activities due to safety concerns. In addition, even if our products are approved,
regulatory agencies may also take post-approval action limiting or revoking our ability to sell our products. Any of these regulatory actions may adversely affect
the economic benefit we may derive from our products and therefore harm our financial condition.
Under certain of these regulations, we and our contract suppliers and manufacturers are subject to periodic inspection of our or their respective facilities,
procedures and operations and/or the testing of products by the FDA, the DEA and other authorities, which conduct periodic inspections to confirm that we and our
contract suppliers and manufacturers are in compliance with all applicable regulations. The FDA also conducts pre-approval and post-approval reviews and plant
inspections to determine whether our systems, or our contract suppliers’ and manufacturers’ processes, are in compliance with cGMP and other FDA regulations. If
we, or our contract supplier, fail these inspections, we may not be able to commercialize our product in a timely manner without incurring significant additional
costs, or at all.
In addition, the FDA imposes a number of complex regulatory requirements on entities that advertise and promote pharmaceuticals including, but not limited
to, standards and regulations for direct-to-consumer advertising, off-label promotion, industry-sponsored scientific and educational activities, and promotional
activities involving the internet.
We may be subject, directly or indirectly, to various broad federal and state healthcare laws. If we are unable to comply, or have not fully complied, with
such laws, we could face civil, criminal and administrative penalties, damages, monetary fines, disgorgement, possible exclusion from participation in
Medicare, Medicaid and other federal healthcare programs, contractual damages, reputational harm, diminished profits and future earnings and
curtailment or restructuring of our operations, any of which could adversely affect our ability to operate.
Our business operations and activities may be directly, or indirectly, subject to various broad federal and state healthcare laws, including without limitation,
anti-kickback laws, the Foreign Corrupt Practices Act (FCPA), false claims laws, civil monetary penalty laws, data privacy and security laws, tracing and tracking
laws, as well as transparency laws regarding payments or other
26
items of value provided to healthcare providers. These laws may restrict or prohibit a wide range of business activities, including, but not limited to, research,
manufacturing, distribution, pricing, discounting, marketing and promotion and other business arrangements. These laws may impact, among other things, our
current activities with principal investigators and research subjects, as well as sales, marketing and education programs. Many states have similar healthcare fraud
and abuse laws, some of which may be broader in scope and may not be limited to items or services for which payment is made by a government health care
program.
Efforts to ensure that our business arrangements will comply with applicable healthcare laws may involve substantial costs. While we have adopted a
healthcare corporate compliance program, it is possible that governmental and enforcement authorities will conclude that our business practices may not comply
with current or future statutes, regulations or case law interpreting applicable fraud and abuse or other healthcare laws. If our operations or activities are found to
be in violation of any of the laws described above or any other governmental regulations that apply to us, we may be subject to, without limitation, civil, criminal
and administrative penalties, damages, monetary fines, disgorgement, possible exclusion from participation in Medicare, Medicaid and other federal healthcare
programs, contractual damages, reputational harm, diminished profits and future earnings and curtailment or restructuring of our operations, any of which could
adversely affect our ability to operate.
In addition, any sales of products outside the U.S. will also likely subject us to the FCPA and foreign equivalents of the healthcare laws mentioned above,
among other foreign laws.
We may be required to initiate or defend against legal proceedings related to intellectual property rights, which may result in substantial expense, delay
and/or cessation of the development and commercialization of our products.
We primarily rely on patents to protect our intellectual property rights. The strength of this protection, however, is uncertain. For example, it is not certain
that:
•
•
•
•
we will be able to obtain patent protection for our products and technologies;
the scope of any of our issued patents will be sufficient to provide commercially significant exclusivity for our products and technologies;
others will not independently develop similar or alternative technologies or duplicate our technologies and obtain patent protection before we do; and
any of our issued patents, or patent pending applications that result in issued patents, will be held valid, enforceable and infringed in the event the
patents are asserted against others.
We currently own or license several patents and also have pending patent applications applicable to rHuPH20 and other proprietary materials. There can be
no assurance that our existing patents, or any patents issued to us as a result of our pending patent applications, will provide a basis for commercially viable
products, will provide us with any competitive advantages, or will not face third party challenges or be the subject of further proceedings limiting their scope or
enforceability. Any weaknesses or limitations in our patent portfolio could have a material adverse effect on our business and financial condition. In addition, if
any of our pending patent applications do not result in issued patents, or result in issued patents with narrow or limited claims, this could result in us having no or
limited protection against generic or biosimilar competition against our product candidates which would have a material adverse effect on our business and
financial condition.
We may become involved in interference proceedings in the U.S. Patent and Trademark Office, or other proceedings in other jurisdictions, to determine the
priority, validity or enforceability of our patents. In addition, costly litigation could be necessary to protect our patent position.
We also rely on trademarks to protect the names of our products (e.g. Hylenex
recombinant). We may not be able to obtain trademark protection for any
proposed product names we select. In addition, product names for pharmaceutical products must be approved by health regulatory authorities such as the FDA in
addition to meeting the legal standards required for trademark protection and product names we propose may not be timely approved by regulatory agencies which
may delay product launch. In addition, our trademarks may be challenged by others. If we enforce our trademarks against third parties, such enforcement
proceedings may be expensive.
We also rely on trade secrets, unpatented proprietary know-how and continuing technological innovation that we seek to protect with confidentiality
agreements with employees, consultants and others with whom we discuss our business. Disputes may
27
arise concerning the ownership of intellectual property or the applicability or enforceability of these agreements, and we might not be able to resolve these disputes
in our favor.
In addition to protecting our own intellectual property rights, third parties may assert patent, trademark or copyright infringement or other intellectual
property claims against us. If we become involved in any intellectual property litigation, we may be required to pay substantial damages, including but not limited
to treble damages, attorneys’ fees and costs, for past infringement if it is ultimately determined that our products infringe a third party’s intellectual property rights.
Even if infringement claims against us are without merit, defending a lawsuit takes significant time, may be expensive and may divert management’s attention
from other business concerns. Further, we may be stopped from developing, manufacturing or selling our products until we obtain a license from the owner of the
relevant technology or other intellectual property rights. If such a license is available at all, it may require us to pay substantial royalties or other fees.
Patent protection for protein-based therapeutic products and other biotechnology inventions is subject to a great deal of uncertainty, and if patent laws or the
interpretation of patent laws change, our competitors may be able to develop and commercialize products based on our discoveries.
Patent protection for protein-based therapeutic products is highly uncertain and involves complex legal and factual questions. In recent years, there have been
significant changes in patent law, including the legal standards that govern the scope of protein and biotechnology patents. Standards for patentability of full-length
and partial genes, and their corresponding proteins, are changing. Recent court decisions have made it more difficult to obtain patents, by making it more difficult
to satisfy the patentable subject matter requirement and the requirement of non-obviousness, have decreased the availability of injunctions against infringers, and
have increased the likelihood of challenging the validity of a patent through a declaratory judgment action. Taken together, these decisions could make it more
difficult and costly for us to obtain, license and enforce our patents. In addition, the Leahy-Smith America Invents Act (HR 1249) was signed into law in
September 2011, which among other changes to the U.S. patent laws, changes patent priority from “first to invent” to “first to file,” implements a post-grant
opposition system for patents and provides for a prior user defense to infringement. These judicial and legislative changes have introduced significant uncertainty
in the patent law landscape and may potentially negatively impact our ability to procure, maintain and enforce patents to provide exclusivity for our products.
There also have been, and continue to be, policy discussions concerning the scope of patent protection awarded to biotechnology inventions. Social and
political opposition to biotechnology patents may lead to narrower patent protection within the biotechnology industry. Social and political opposition to patents on
genes and proteins and recent court decisions concerning patentability of isolated genes may lead to narrower patent protection, or narrower claim interpretation,
for isolated genes, their corresponding proteins and inventions related to their use, formulation and manufacture. Patent protection relating to biotechnology
products is also subject to a great deal of uncertainty outside the U.S., and patent laws are evolving and undergoing revision in many countries. Changes in, or
different interpretations of, patent laws worldwide may result in our inability to obtain or enforce patents, and may allow others to use our discoveries to develop
and commercialize competitive products, which would impair our business.
If third party reimbursement and customer contracts are not available, our products may not be accepted in the market.
Our ability to earn sufficient returns on our products will depend in part on the extent to which reimbursement for our products and related treatments will be
available from government health administration authorities, private health insurers, managed care organizations and other healthcare providers.
Third-party payors are increasingly attempting to limit both the coverage and the level of reimbursement of new drug products to contain costs.
Consequently, significant uncertainty exists as to the reimbursement status of newly approved healthcare products. Third party payors may not establish adequate
levels of reimbursement for the products that we commercialize, which could limit their market acceptance and result in a material adverse effect on our revenues
and financial condition.
Customer contracts, such as with group purchasing organizations and hospital formularies, will often not offer contract or formulary status without either the
lowest price or substantial proven clinical differentiation. If, for example, Hylenex is compared to animal-derived hyaluronidases by these entities, it is possible
that neither of these conditions will be met, which could limit market acceptance and result in a material adverse effect on our revenues and financial condition.
28
The rising cost of healthcare and related pharmaceutical product pricing has led to cost containment pressures that could cause us to sell our products at
lower prices, resulting in less revenue to us.
Any of the proprietary or collaboration products that have been, or in the future are, approved by the FDA may be purchased or reimbursed by state and
federal government authorities, private health insurers and other organizations, such as health maintenance organizations and managed care organizations. Such
third party payors increasingly challenge pharmaceutical product pricing. The trend toward managed healthcare in the U.S., the growth of such organizations, and
various legislative proposals and enactments to reform healthcare and government insurance programs, including the Medicare Prescription Drug Modernization
Act of 2003, could significantly influence the manner in which pharmaceutical products are prescribed and purchased, resulting in lower prices and/or a reduction
in demand. Such cost containment measures and healthcare reforms could adversely affect our ability to sell our products.
In March 2010, the U.S. adopted the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act (the
PPACA). This law substantially changes the way healthcare is financed by both governmental and private insurers, and significantly impacts the pharmaceutical
industry. The PPACA contains a number of provisions that are expected to impact our business and operations, in some cases in ways we cannot currently predict.
Changes that may affect our business include those governing enrollment in federal healthcare programs, reimbursement changes, fraud and abuse and
enforcement. These changes will impact existing government healthcare programs and will result in the development of new programs, including Medicare
payment for performance initiatives and improvements to the physician quality reporting system and feedback program.
Additional provisions of the PPACA may negatively affect our revenues in the future. For example, the PPACA imposes a non-deductible excise tax on
pharmaceutical manufacturers or importers that sell branded prescription drugs to U.S. government programs that we believe will impact our revenues from our
products. In addition, as part of the PPACA’s provisions closing a funding gap that currently exists in the Medicare Part D prescription drug program, we will also
be required to provide a discount on branded prescription drugs dispensed to beneficiaries under this prescription drug program. Recently, Congress and the current
administration have proposed and taken various steps to revise, repeal or delay implementation of, various aspects of the Healthcare Reform Act. We expect that
the PPACA, as it may be amended, and other healthcare reform measures that may be adopted in the future could have a material adverse effect on our industry
generally and on our ability to maintain or increase our product sales or successfully commercialize our product candidates and could limit or eliminate our future
spending on development projects.
Furthermore, individual states have become increasingly aggressive in passing legislation and implementing regulations designed to control pharmaceutical
product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access, importation from other countries and bulk
purchasing. Legally mandated price controls on payment amounts by third party payors or other restrictions could negatively and materially impact our revenues
and financial condition. We anticipate that we will encounter similar regulatory and legislative issues in most other countries outside the U.S.
We face intense competition and rapid technological change that could result in the development of products by others that are competitive with or superior
to our proprietary and collaboration products under development.
Our proprietary and collaboration products have numerous competitors in the U.S. and abroad including, among others, major pharmaceutical and specialized
biotechnology firms, universities and other research institutions that have developed competing products. The competitors for Hylenex
recombinant include, but are
not limited to, Valeant Pharmaceuticals International, Inc.’s FDA-approved product, Vitrase ® , an ovine (ram) hyaluronidase, and Amphastar Pharmaceuticals,
Inc.’s product, Amphadase ® , a bovine (bull) hyaluronidase. For our PEGPH20 product candidate and our ENHANZE technology, such competitors may include
major pharmaceutical and specialized biotechnology firms. These competitors may develop technologies and products that are more effective, safer, or less costly
than our current or future proprietary and collaboration product candidates or that could render our technologies and product candidates obsolete or
noncompetitive. Many of these competitors have substantially more resources and product development, manufacturing and marketing experience and capabilities
than we do. In addition, many of our competitors have significantly greater experience than we do in undertaking preclinical testing and clinical trials of
pharmaceutical product candidates and obtaining FDA and other regulatory approvals of products and therapies for use in healthcare.
Item 1B. Unresolved Staff Comments
None.
29
Item 2. Properties
Our administrative offices and research facilities are currently located in San Diego, California. We lease an aggregate of approximately 80,000 square feet
of office and research space. In addition, we have an office in South San Francisco, California, where we lease approximately 10,000 square feet of office space.
We believe our facilities are adequate for our current and near-term needs, and, if necessary, we will be able to locate additional facilities as needed.
Item 3.
Legal Proceedings
From time to time, we may be involved in disputes, including litigation, relating to claims arising out of operations in the normal course of our business. Any
of these claims could subject us to costly legal expenses and, while we generally believe that we have adequate insurance to cover many different types of
liabilities, our insurance carriers may deny coverage or our policy limits may be inadequate to fully satisfy any damage awards or settlements. If this were to
happen, the payment of any such awards could have a material adverse effect on our consolidated results of operations and financial position. Additionally, any
such claims, whether or not successful, could damage our reputation and business. We currently are not a party to any legal proceedings, the adverse outcome of
which, in management’s opinion, individually or in the aggregate, would have a material adverse effect on our consolidated results of operations or financial
position.
Item 4.
Mine Safety Disclosures
Not applicable.
30
PART II
Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
Market Information
Our common stock is listed on the NASDAQ Global Select Market under the symbol “HALO.” As of February 14, 2019 , we had approximately 18,250
stockholders of record and beneficial owners of our common stock.
Dividends
We have never declared or paid any dividends on our common stock. We currently intend to retain available cash for funding operations; therefore, we do
not expect to pay any dividends on our common stock in the foreseeable future. In addition, the provisions of our borrowing arrangements limit, among other
things, our ability to pay dividends and make certain other payments. Any future determination to pay dividends on our common stock will be at the discretion of
our board of directors and will depend upon, among other factors, our results of operations, financial condition, capital requirements, contract restrictions, business
prospects and other factors our board of directors may deem relevant.
31
Stock Performance Graph and Cumulative Total Return
Notwithstanding
any
statement
to
the
contrary
in
any
of
our
previous
or
future
filings
with
the
SEC,
the
following
information
relating
to
the
price
performance
of
our
common
stock
shall
not
be
deemed
to
be
“filed”
with
the
SEC
or
to
be
“soliciting
material”
under
the
Securities
Exchange
Act
of
1934,
as
amended,
or
the
Exchange
Act,
and
it
shall
not
be
deemed
to
be
incorporated
by
reference
into
any
of
our
filings
under
the
Securities
Act
of
1933,
as
amended,
or
the
Exchange
Act,
except
to
the
extent
we
specifically
incorporate
it
by
reference
into
such
filing.
The graph below compares Halozyme Therapeutics, Inc.’s cumulative five-year total shareholder return on common stock with the cumulative total returns
of the NASDAQ Composite Index and the NASDAQ Biotechnology Index. The graph tracks the performance of a $100 investment in our common stock and in
each of the indexes (with the reinvestment of all dividends) from December 31, 2013 to December 31, 2018. The historical stock price performance included in this
graph is not necessarily indicative of future stock price performance.
32
Halozyme Therapeutics, Inc.
NASDAQ Composite
NASDAQ Biotechnology
Item 6.
Selected Financial Data
12/31/2013
$100
12/31/2014
$64
12/31/2015
$116
12/31/2016
$66
12/31/2017
$135
12/31/2018
$98
$100
$100
$115
$134
$123
$150
$134
$118
$173
$144
$158
$140
The selected consolidated financial data set forth below as of December 31, 2018 and 2017 , and for the years ended December 31, 2018, 2017 and 2016 , are
derived from our audited consolidated financial statements included elsewhere in this report. This information should be read in conjunction with those
consolidated financial statements, the notes thereto, and with “ Management’s
Discussion
and
Analysis
of
Financial
Condition
and
Results
of
Operations
.” The
selected consolidated financial data set forth below as of December 31, 2016, 2015 and 2014, and for the years ended December 31, 2015 and 2014, are derived
from our audited consolidated financial statements that are contained in reports previously filed with the SEC, not included herein.
Statement of Operations Data:
2018
2017
2016
2015
2014
Summary Financial Information
Year Ended December 31,
Total revenues
Net (loss) income
Net (loss) income per share, basic
Net (loss) income per share, diluted
Shares used in computing net (loss) income per share, basic
Shares used in computing net (loss) income per share, diluted
Balance Sheet Data:
Cash and cash equivalents and available-for-sale marketable
securities
Working capital
Total assets
Deferred revenue
Long-term debt, net
Total liabilities
Stockholders’ equity (deficit)
$
$
$
$
$
$
$
$
$
$
$
151,862 $
(in thousands, except for per share amounts)
316,613 $
146,691 $
135,057 $
75,334
(80,330) $
62,971 $
(103,023) $
(32,231) $
(68,375)
(0.56) $
(0.56) $
0.46 $
0.45 $
(0.81) $
(0.81) $
(0.25) $
(0.25) $
143,599
143,599
136,419
139,068
127,964
127,964
126,704
126,704
(0.56)
(0.56)
122,690
122,690
As of December 31,
2018
2017
2016
2015
2014
(in thousands)
354,526 $
469,214 $
204,981 $
108,339 $
278,488 $
379,044 $
201,947 $
109,315 $
440,248 $
519,945 $
261,515 $
181,789 $
9,255 $
60,865 $
44,618 $
53,223 $
34,874 $
125,140 $
199,228 $
27,971 $
135,623
136,990
165,977
54,634
49,860
191,361 $
311,579 $
293,996 $
138,790 $
124,625
248,887 $
208,366 $
(32,481) $
42,999 $
41,352
33
Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operation
In
addition
to
historical
information,
the
following
discussion
contains
forward-looking
statements
that
are
subject
to
risks
and
uncertainties.
Actual
results
may
differ
substantially
from
those
referred
to
herein
due
to
a
number
of
factors,
including
but
not
limited
to
risks
described
in
the
Part
I,
Item
1A,
Risks
Factors,
and
elsewhere
in
this
Annual
Report.
References
to
“Notes”
are
Notes
included
in
our
Notes
to
Consolidated
Financial
Statements.
Overview
Halozyme Therapeutics, Inc. is a biotechnology company focused on developing and commercializing novel oncology therapies. Our proprietary enzymes
are used to facilitate the delivery of injected drugs and fluids, potentially enhancing the efficacy and the convenience of other drugs or can be used to alter tissue
structures for potential clinical benefit. We exploit our technology and expertise using a two pillar strategy that we believe enables us to manage risk and cost by:
(1) developing our own proprietary products in therapeutic areas with significant unmet medical needs, with a focus on oncology, and (2) licensing our technology
to biopharmaceutical companies to collaboratively develop products that combine our technology with the collaborators’ proprietary compounds.
The majority of our approved product and product candidates are based on rHuPH20, our patented recombinant human hyaluronidase enzyme. Our
proprietary development pipeline consists primarily of pre-clinical and clinical stage product candidates in oncology. Our lead oncology program is
Pegvorhyaluronidase alfa (PVHA), also referred to as PEGylated recombinant human hyaluronidase (PEGPH20), a molecular entity we are developing in
combination with currently approved cancer therapies as a candidate for the systemic treatment of tumors that accumulate HA. We have demonstrated that when
HA accumulates in a tumor, it can cause higher pressure in the tumor, reducing blood flow into the tumor and with that, reduced access of cancer therapies to the
tumor. Through our efforts and efforts of our partners and collaborators, we are currently in Phase 3 clinical testing for PEGPH20 with ABRAXANE ® (nab-
paclitaxel) and gemcitabine in stage IV pancreatic ductal adenocarcinoma (“PDA”) (HALO 109-301), in Phase 1b clinical testing for PEGPH20 with KEYTRUDA
® (pembrolizumab) in non-small cell lung cancer (HALO 107-101), in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq ® (atezolizumab) in patients with
previously treated metastatic PDA, in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq in patients with gastric cancer and in Phase 1b/2 clinical testing for
PEGPH20 with Tecentriq in patients with cholangiocarcinoma and gall bladder cancer (HALO 110-101/MATRIX).
We refer to the application of rHuPH20 to facilitate the delivery of other drugs or fluids as our ENHANZE ® Drug Delivery Technology (ENHANZE). We
license the ENHANZE technology to form collaborations with biopharmaceutical companies that develop or market drugs requiring or benefiting from injection
via the subcutaneous route of administration. We currently have ENHANZE collaborations with F. Hoffmann-La Roche, Ltd. and Hoffmann-La Roche, Inc.
(Roche), Baxalta US Inc. and Baxalta GmbH (now members of the Takeda group of companies, following the acquisition of Shire plc by Takeda Pharmaceutical
Company Limited in January 2019) (Baxalta), Pfizer Inc. (Pfizer), Janssen Biotech, Inc. (Janssen), AbbVie, Inc. (AbbVie), Eli Lilly and Company (Lilly), Bristol-
Myers Squibb Company (BMS), Alexion Pharma Holding (Alexion) and ARGENX BVBA (argenx).We receive royalties from two of these collaborations,
including royalties from sales of one product from the Baxalta collaboration and two products from the Roche collaboration. Future potential revenues from the
sales and/or royalties of our approved products, product candidates, and ENHANZE collaborations will depend on the ability of Halozyme and our collaborators to
develop, manufacture, secure and maintain regulatory approvals for approved products and product candidates and commercialize product candidates.
34
Our 2018 and recent key events are as follows:
ENHANZE
collaborations
•
•
•
•
•
•
•
•
•
•
•
•
In February 2019, we entered into an agreement with argenx for the right to develop and commercialize one exclusive target, the human neonatal Fc
receptor FcRn, which includes argenx's lead asset efgartigimod (ARGX-113), and an option to select two additional targets using our ENHANZE
technology for an upfront payment of $30.0 million. We will receive payments of $10.0 million per target for future target nominations and potential
milestone payments of up to $160.0 million per target, subject to the achievement of specific development, regulatory and sales-based milestones. We will
receive mid-single digit royalties on sales of commercialized products.
In December 2018, Roche initiated a Ph1b/2 study start in patients with non-small cell lung cancer for TECENTRIQ (atezolizumab) in combination with
our ENHANZE technology, triggering a $5.0 million milestone payment.
In October 2018, we entered into an agreement with Roche for the right to develop and commercialize one additional exclusive target and an option to
select two additional targets within four years using our ENHANZE technology for an upfront payment of $25.0 million. We will receive potential
milestone payments of up to $160.0 million to $165.0 million per target, subject to the achievement of specific development, regulatory and sales-based
milestones. We will also receive mid-single digit royalties on sales of commercialized products.
In October 2018, BMS dosed the first patient in a Phase 1 study evaluating the safety, pharmacokinetics and pharmacodynamics of BMS-986179, an
investigational anti-CD-73 antibody, and ENHANZE technology, triggering a $5.0 million milestone payment.
In September 2018, we announced that Roche received approval from Health Canada for a subcutaneous formulation of Herceptin (trastuzumab) for the
treatment of patients with HER2-positive breast cancer. This is a co-formulation with our ENHANZE technology.
In August 2018, Alexion initiated a Phase 1 trial to study a next-generation subcutaneous formulation of ALXN1210 co-administered with ENHANZE
technology, triggering a $5.0 million milestone payment.
In July 2018, we announced the FDA accepted a Biologics License Application (BLA) from Genentech, a member of the Roche Group, for a
subcutaneous version of Herceptin in its FDA-approved breast cancer indications. This is the same co-formulation with ENHANZE technology marketed
under the Herceptin SC brand in many countries outside the U.S.
In June 2018, Roche initiated a global Phase 3 study of a fixed-dose combination of Perjeta ® (pertuzumab) and Herceptin (trastuzumab) with ENHANZE
technology in patients with HER2-positive early breast cancer. This study follows supportive Phase 1 results from the same combination shared at the
2017 San Antonio Breast Cancer Symposium.
In January 2018, Roche initiated a Phase 1 study for an undisclosed target with ENHANZE Technology, triggering a $1.0 million milestone payment.
Clinical
trials
In November 2018, the FDA agreed to our request to change the primary endpoint of the HALO-301 study from two primary endpoints of progression-
free survival (PFS) and overall survival (OS) to a single primary endpoint of OS. As a result, the previously planned interim analysis for the PFS endpoint
will not be conducted. In January 2019, the FDA completed their review of the submitted clinical study protocol amendment and statistical analysis plan
with no additional questions or comments. The study completed enrollment with approximately 500 patients by the end of 2018.
In March 2018, the U.S. Patent and Trademark Office granted us a patent covering the combination of PEGPH20, ABRAXANE and gemcitabine. This is
the combination being studied in our HALO-301 registration trial in pancreas cancer. Following this action, we obtained exclusive rights to the claimed
combination through March 2033. The same application is pending or has been issued in multiple countries outside of the United States.
In January 2018, the Phase 1b portion of the study of HALAVEN (eribulin) with PEGPH20 in HER2-negative metastatic breast cancer closed enrollment.
As a result of an Eisai portfolio decision, no further clinical development is planned on
35
the Phase 2 portion of the study. Results from this study were presented at the 2018 Annual Meeting of the European Society of Medical Oncology
(ESMO).
Results of Operations
Comparison of Years Ended December 31, 2018, 2017 and 2016
Royalties
– Royalty revenue was $79.0 million in 2018 compared to $63.5 million in 2017 and $51.0 million in 2016 . The increase was driven by higher
sales of Herceptin SC and MabThera SC (RITUXAN HYCELA™ in the U.S.) by Roche and of HYQVIA by Baxalta. In general, we expect royalty revenue to
increase in future periods reflecting expected increases in sales of collaboration products, although there may be periods with flat or declining royalty revenue as
sales of products under collaborations vary.
Product
Sales,
Net
– Product sales, net were as follows (in thousands):
Sales of Hylenex
Sales of bulk rHuPH20:
Roche
Janssen
Baxalta
Other
Sales of ENHANZE drug product
Total product sales, net
2018
Change
2017
Change
2016
$
15,045
(1)% $
15,150
(6)% $
16,157
6,767
2,510
1,820
1,632
460
(70)%
22,325
(10)%
24,786
n/a
(84)%
36 %
n/a
—
11,717
1,204
—
n/a
5 %
(10)%
n/a
—
11,117
1,332
—
$
28,234
(44)% $
50,396
(6)% $
53,392
Product sales, net decreased in 2018 compared to 2017 , primarily due to a decrease in the sales of bulk rHuPH20 to Roche and Baxalta, partially offset by an
increase in sales of bulk rHuPH20 to Janssen. As previously anticipated, Roche and Baxalta are depleting their existing inventory of rHuPH20 ahead of planned
transitions to new manufacturing facilities, which resulted in lower bulk rHuPH20 product sales during 2018. Product sales, net decreased in 2017 compared to
2016 , mainly due to decreases in the sales of bulk rHuPH20 to Roche and Hylenex
, partially offset by an increase in sales of bulk rHuPH20 to Baxalta. We expect
that product sales of bulk rHuPH20 and ENHANZE drug product will fluctuate in future periods based on the needs of our collaborators. We expect that future
product sales of Hylenex
to be flat or declining as we experience competition for market share.
Revenues
Under
Collaborative
Agreements
– Revenues under collaborative agreements were as follows (in thousands):
Upfront license fees, license fees for the election of additional targets, event-
based payments, license maintenance fees and amortization of deferred
upfront and other license fees:
2018
Change
2017
Change
2016
Roche
BMS
Alexion
Other
Reimbursements for research and development services:
Roche
Other
$
31,000
(7)% $
33,330
902 % $
3,328
6,336
5,000
(94)%
(88)%
—
(100)%
101,400
40,000
15,810
42,336
(78)%
190,540
1,369
942
2,311
(80)%
(82)%
(81)%
6,900
5,270
12,170
n/a
n/a
(10%)
814%
(63%)
90 %
(43%)
—
—
17,515
20,843
18,700
2,772
21,472
42,315
Total revenues under collaborative agreements
$
44,647
(78)% $
202,710
379% $
Revenue from license fees decreased in 2018 , compared to 2017 due to $41.0 million in upfront license fees and milestone revenue for the Roche, BMS and
Alexion Collaborations recognized in 2018, compared to $186.4 million in upfront license fees
36
and milestone revenue for the Roche, BMS, Alexion and Janssen Collaborations recognized in 2017. In 2016, we recognized $15.5 million in license fee and
milestone revenue in connection with the Lilly, AbbVie and Pfizer collaborations. Revenue from upfront licenses fees, license fees for the election of additional
targets, license maintenance fees and other license fees and event-based payments vary from period to period based on our ENHANZE collaboration activity. We
expect these revenues to continue to fluctuate in future periods based on our collaborators’ ability to meet various clinical and regulatory milestones set forth in
such agreements and our abilities to obtain new collaborative agreements.
Revenue from reimbursements for research and development services decreased in 2018 compared to 2017, mainly due to a decrease in services provided to
Roche related to the validation of a new manufacturing facility, which was was completed in the second quarter of 2017, combined with a decrease in services
provided to Janssen and Baxalta. Research and development services rendered by us on behalf of our collaborators are at the request of the collaborators; therefore,
the amount of future revenues related to reimbursable research and development services is uncertain.
Cost
of
Product
Sales
– Cost of product sales were $10.1 million in 2018 compared to $31.2 million in 2017 and $33.2 million in 2016 . The decrease of
$21.1 million in cost of product sales in 2018 compared to 2017 and the decrease of $2.0 million in 2017 compared to 2016 were mainly due to a decrease in sales
of bulk rHuPH20 to Roche and Baxalta. There were $2.6 million in costs of bulk rHuPH20 and ENHANZE drug product sales for the year ended December 31,
2018 that were previously expensed as research and development.
Research
and
Development
– Research and development expenses consist of external costs, salaries and benefits and allocation of facilities and other
overhead expenses related to research manufacturing, clinical trials, preclinical and regulatory activities. Research and development expenses incurred were as
follows (in thousands):
Programs
PEGPH20
ENHANZE collaborations and rHuPH20 platform
Other
2018
Change
2017
Change
2016
$
131,064
6 % $
123,932
15 % $
108,102
17,242
1,946
(10)%
(74)%
19,197
7,514
(37)%
(39)%
30,398
12,342
Total research and development expenses
$
150,252
— $
150,643
— % $
150,842
Research and development expenses relating to our PEGPH20 program increased in 2018 by 6% compared to 2017 , primarily due to increased clinical trial
activities related to the HALO-301 study and the HALO 110-101 study, partially offset by decreased clinical trial activities related to the HALO-202 study, the
HALO 107-101 study, and the Eisai clinical collaboration. Research and development expenses relating to our PEGPH20 program increased in 2017 by 15%
compared to 2016 , primarily due to increased clinical trial activities. We expect these expenses to continue to increase in the near term.
Research and development expenses relating to our ENHANZE collaborations and our rHuPH20 platform in 2018 decreased by 10% compared to 2017 ,
primarily due to a decrease in expenses incurred to establish an additional contract manufacturing facility, which was completed in the second quarter of 2017, and
a decrease in manufacturing inventory with no alternative use, partially offset by increased costs to support new partners and targets related to our ENHANZE
collaboration activity. Research and development expenses relating to our ENHANZE collaborations and our rHuPH20 platform in 2017 decreased by 37%
compared to 2016, primarily due to a decrease in manufacturing expenses related to the new contract manufacturing facility. We expect research and development
expenses relating to our ENHANZE collaborations and our rHuPH20 platform to increase in the near term as we support our collaboration partners advancing
through clinical development and preparation for commercialization. The rHuPH20 platform includes research, development and manufacturing expenses related
to our proprietary rHuPH20 enzyme. When these expenses were incurred, they were not designated to a specific program.
Research and development expenses related to other programs decreased in 2018 by 74% compared to 2017 , and decreased in 2017 by 39% compared to
2016 , primarily due to a decrease in preclinical development of HTI-1511 and PEG-ADA2.
Selling,
General
and
Administrative
– Selling, general and administrative (SG&A) expenses increased in 2018 compared to 2017 by $7.0 million , or 13% ,
primarily due to increases in market research expense as we prepare for a potential commercial launch of PEGPH20 and compensation expense including stock
compensation. SG&A expenses increased in 2017 compared to
37
2016 by $8.0 million , or 17% , primarily due to increases in compensation expense including stock compensation. We expect SG&A expenses to increase in future
periods as our operations expand and we prepare for commercial launch.
Interest
Expense
– Interest expense included interest expense and amortization of the debt discount related to the long-term debt. Interest expense decreased
by $3.9 million in 2018 compared to 2017 primarily due to a decrease in the Royalty-backed Loan balance. Interest expense increased by $2.0 million in 2017 as
compared to 2016 , primarily due to interest expense incurred on the Royalty-backed Loan we received in January 2016.
Income
Taxes
– Income tax expense was $0.5 million in 2018 compared to income tax benefit of $1.4 million in 2017 . The 2018 amount was comprised
primarily of state income tax while the 2017 benefit was primarily comprised of U.S. federal alternative minimum tax expense in the amount of $4.1 million offset
by a U.S federal alternative minimum tax credit of $5.5 million . Income tax expense of $1.2 million in 2016 comprised of U.S. federal alternative minimum tax.
The U.S. federal AMT was eliminated via the Tax Cuts and Jobs Act that was enacted on December 22, 2017. The AMT credit carryovers will be used to offset
regular tax liability for any taxable year beginning after 2017. If not utilized before 2022, any remaining AMT credit carryforward amount is fully refundable. The
remaining AMT credit carryforward of $3.0 million was recognized as a deferred tax asset at December 31, 2018 as realization is certain. For the years ended
December 31, 2018, 2017 and 2016, we generated taxable income in the U.S., which was partially offset by utilizing net operating losses carried forward from
earlier years.
Liquidity and Capital Resources
Our principal sources of liquidity are our existing cash, cash equivalents and available-for-sale marketable securities. As of December 31, 2018 , we had
cash, cash equivalents and marketable securities of $354.5 million . We will continue to have significant cash requirements to support product development
activities. The amount and timing of cash requirements and cash on hand will depend on the progress and success of our clinical development programs, regulatory
and market acceptance, the resources we devote to research and commercialization activities and the achievement of various milestones and royalties under our
existing collaborative agreements.
We believe that our current cash, cash equivalents and marketable securities will be sufficient to fund our operations for at least the next twelve months. We
expect to fund our operations going forward with existing cash resources, anticipated revenues from our existing collaborations and cash that we may raise through
future transactions. We may raise cash through any one of the following financing vehicles: (i) the public offering of securities; (ii) new collaborative agreements;
(iii) expansions or revisions to existing collaborative relationships; (iv) private financings; (v) other equity or debt financings; and/or (vi) monetizing assets.
In February 2017, we filed an automatic shelf registration statement on Form S-3 (Registration No. 333-216315) with the SEC, which allow us, from time to
time, to offer and sell equity, debt securities and warrants to purchase any of such securities, either individually or in units. In May 2017, we completed an
underwritten public offering pursuant to which we sold 11.5 million shares of common stock, generating $134.9 million in net proceeds, after deducting
underwriting discounts and commissions and other offering expenses. We may, in the future, offer and sell additional equity, debt securities and warrants to
purchase any of such securities, either individually or in units to raise capital to fund the continued development of our product candidates, the commercialization
of our products or for other general corporate purposes.
Our existing cash, cash equivalents and marketable securities may not be adequate to fund our operations until we become profitable, if ever. We cannot be
certain that additional financing will be available when needed or, if available, financing will be obtained on favorable terms. If we are unable to raise sufficient
funds, we may need to delay, scale back or eliminate some or all of our research and development programs, delay the launch of our product candidates, if
approved, and/or restructure our operations. If we raise additional funds by issuing equity securities, substantial dilution to existing stockholders could result. If we
raise additional funds by incurring debt financing, the terms of the debt may involve significant cash payment obligations, the issuance of warrants that may
ultimately dilute existing stockholders when exercised and covenants that may restrict our ability to operate our business.
38
Cash Flows
Operating
Activities
Net cash used in operations was $49.5 million in 2018 compared to net cash provided by operations of $134.1 million in 2017 . The increase in utilization of
cash in operations was mainly due to lower net income as a result of reduced revenues combined with an increase in working capital for the year ended
December 31, 2018 compared to the prior year.
Net cash provided by operations was $134.1 million in 2017 compared to net cash used in operations of $50.4 million in 2016. The increase in cash provided
by operations was mainly due to an increase in operating income driven by license payments and milestones achieved and changes in working capital for the year
ended December 31, 2017 compared to the prior year.
Investing
Activities
Net cash provided by investing activities was $2.5 million in 2018 compared to net cash used in investing activities of $163.7 million in 2017 . The increase
in net cash provided by investing activities was primarily due to an increase in proceeds from maturities of marketable securities and less purchases of marketable
securities.
Net cash used in investing activities was $163.7 million in 2017 compared to net cash used in investing activities of $76.8 million in 2016. The increase in
net cash used in investing activities was primarily due to net purchases of marketable securities using cash provided by operating and financing activities.
Financing
Activities
Net cash used in financing activities was $63.8 million in 2018 , compared to net cash provided by financing activities of $131.7 million in 2017 , mainly due
to $134.9 million in net proceeds from the sale of common stock in a public offering in May 2017 compared to no sale of common stock in a public offering
occurring and an increase in the amount of long-term debt repayment in 2018.
Net cash provided by financing activities was $131.7 million in 2017, primarily due to $134.9 million in net proceeds from the sale of common stock in May
2017, compared to cash provided by financing activities of $150.6 million in 2016, when we drew net proceeds of $148.0 million on the Royalty-backed Loan.
Long-Term
Debt
Royalty-backed
Loan
In January 2016, through our wholly-owned subsidiary Halozyme Royalty LLC (Halozyme Royalty), we received a $150 million loan (the Royalty-backed
Loan) pursuant to a credit agreement (the Credit Agreement) with BioPharma Credit Investments IV Sub, LP and Athyrium Opportunities II Acquisition LP (the
Royalty-backed Lenders). Under the terms of the Credit Agreement, Halozyme Therapeutics, Inc. transferred to Halozyme Royalty the right to receive royalty
payments from the commercial sales of ENHANZE products owed under the Roche Collaboration and Baxalta Collaboration (Collaboration Agreements). The
royalty payments from the Collaboration Agreements will be used to repay the principal and interest on the loan (the Royalty Payments). The Royalty-backed
Loan bears interest at a per annum rate of 8.75% plus the three-month LIBOR rate. The three-month LIBOR rate is subject to a floor of 0.7% and a cap of 1.5%.
The interest rate as of December 31, 2018 was 10.25% . The outstanding balance of the Royalty-backed Loan as of December 31, 2018 was $85.0 million , net of
unamortized debt discount of $0.3 million.
39
The Credit Agreement provides that none of the Royalty Payments were required to be applied to the Royalty-backed Loan prior to January 1, 2017, 50% of
the Royalty Payments were required to be applied to the Royalty-backed Loan between January 1, 2017 and January 1, 2018 and thereafter all Royalty Payments
must be applied to the Royalty-backed Loan. However, the amounts available to repay the Royalty-backed Loan are subject to caps of $13.75 million per quarter in
2017, $18.75 million per quarter in 2018, $21.25 million per quarter in 2019 and $22.5 million per quarter in 2020 and thereafter. Amounts available to repay the
Royalty-backed Loan will be applied first, to pay interest and second, to repay principal on the Royalty-backed Loan. Any accrued interest that is not paid on any
applicable quarterly payment date, as defined, will be capitalized and added to the principal balance of the Royalty-backed Loan on such date. Halozyme Royalty
will be entitled to receive and distribute to Halozyme any Royalty Payments that are not required to be applied to the Royalty-backed Loan or which are in excess
of the foregoing caps.
The final maturity date of the Royalty-backed Loan will be the earlier of (i) the date when principal and interest is paid in full, (ii) the termination of
Halozyme Royalty’s right to receive royalties under the Collaboration Agreements, and (iii) December 31, 2050. Currently, we estimate that the loan will be repaid
in the first quarter of 2020. This estimate could be adversely affected and the repayment period could be extended if future royalty amounts are less than currently
expected. Under the terms of the Credit Agreement, at any time after January 1, 2019, Halozyme Royalty may, subject to certain limitations, prepay the
outstanding principal of the Royalty-backed Loan in whole or in part, at a price equal to 105% of the outstanding principal on the Royalty-backed Loan, plus
accrued but unpaid interest. The Royalty-backed Loan constitutes an obligation of Halozyme Royalty, and is non-recourse to Halozyme. Halozyme Royalty retains
its right to the Royalty Payments following repayment of the loan.
Oxford
and
SVB
Loan
and
Security
Agreement
In June 2016, we entered into a Loan and Security Agreement (the Loan Agreement) with Oxford Finance LLC (Oxford) and Silicon Valley Bank (SVB)
(collectively, the Lenders), providing a senior secured loan facility of up to an aggregate principal amount of $70 million, comprising a $55.0 million draw in June
2016 and an additional $15.0 million tranche, which we had the option to draw during the second quarter of 2017 and did not exercise. The proceeds were partially
used to pay the outstanding principal and final payment owed on a previous loan agreement with the Lenders. The remaining proceeds are being used for working
capital and general business requirements. The Loan Agreement repayment schedule provides for interest only payments for the first 18 months, followed by
consecutive equal monthly payments of principal and interest in arrears through the maturity date of January 1, 2021. The Loan Agreement provides for a final
payment equal to 5.50% of the initial $55 million principal amount. The final payment is due when the Loan Agreement becomes due or upon the prepayment of
the facility. We have the option to prepay the outstanding balance of the Loan Agreement in full. The outstanding term loan balance was $41.4 million as of
December 31, 2018 , inclusive of $2.2 million of accretion of the final payment and net of unamortized discount related to offering costs of $0.2 million.
The Loan Agreement is secured by substantially all of the assets of the Company and its subsidiary, Halozyme, Inc., except that the collateral does not
include any equity interests in Halozyme, Inc. and any intellectual property (including all licensing, collaboration and similar agreements relating thereto), and
certain other excluded assets. The Loan Agreement contains customary representations, warranties and covenants by us, which covenants limit our ability to
convey, sell, lease, transfer, assign or otherwise dispose of certain of our assets; engage in any business other than the businesses currently engaged in by us or
reasonably related thereto; liquidate or dissolve; make certain management changes; undergo certain change of control events; create, incur, assume, or be liable
with respect to certain indebtedness; grant certain liens; pay dividends and make certain other restricted payments; make certain investments; make payments on
any subordinated debt; enter into transactions with any of our affiliates outside of the ordinary course of business or permit our subsidiaries to do the same; and
make any voluntary prepayment of or modify certain terms of the Royalty-backed Loan. In addition, subject to certain exceptions, we are required to maintain with
SVB our primary deposit accounts, securities accounts and commodities, and to do the same for our domestic subsidiary.
40
The Loan Agreement also contains customary indemnification obligations and customary events of default, including, among other things, our failure to
fulfill certain of our obligations under the Loan Agreement and the occurrence of a material adverse change which is defined as a material adverse change in our
business, operations or condition (financial or otherwise), a material impairment of the prospect of repayment of any portion of the loan, a material impairment in
the perfection or priority of the Lender’s lien in the collateral or in the value of such collateral or the occurrence of an event of default under the Royalty-backed
Loan. In the event of default by us under the Loan Agreement, the Lenders would be entitled to exercise their remedies thereunder, including the right to accelerate
the debt, upon which we may be required to repay all amounts then outstanding under the Loan Agreement, which could harm our financial condition.
Off-Balance Sheet Arrangements
As of December 31, 2018 , we did not have any relationships with unconsolidated entities or financial partnerships, such as entities often referred to as
structured finance or special purpose entities, which would have been established for the purpose of facilitating off-balance sheet arrangements or other
contractually narrow or limited purposes. In addition, we did not engage in trading activities involving non-exchange traded contracts. As such, we are not
materially exposed to any financing, liquidity, market or credit risk that could arise if we had engaged in such relationships.
Contractual Obligations
As of December 31, 2018 , future minimum payments due under our contractual obligations are as follows (in thousands):
Contractual Obligations (1)
Long-term debt, including current portion (2)
Interest on long-term debt (3)
Operating leases (4)
Third-party manufacturing obligations (5)
Purchase obligations
Total
_______________
Total
127,642 $
$
Payments Due by Period
Less than
1 Year
1-3 Years
4-5 Years
More than
5 Years
91,506 $
36,136 $
— $
10,191
11,123
14,985
2,862
8,664
2,953
14,985
1,527
8,058
—
327
2,535
—
112
—
—
$
166,803 $
118,435 $
48,256 $
112 $
—
—
—
—
—
—
(1) Does not include milestone or contractual payment obligations contingent upon the achievement of certain milestones or events if the amount and
timing of such obligations are unknown or uncertain. Our in-license agreement is cancelable by us with written notice within 90 days. We may be
required to pay up to approximately $8.0 million in milestone payments, plus sales royalties, in the event that regulatory and commercial milestones
under the in-license agreement are achieved. Also excludes contractual obligations already recorded on our consolidated balance sheet as current
liabilities.
(2) Long-term debt consists of the Royalty-backed Loan and the Loan Agreement. Obligations include future quarterly principal payments for the Royalty-
backed Loan based on an estimate of future royalty amounts. This estimate could be adversely affected and the repayment period could be extended if
future royalty amounts are less than currently expected. Obligations also include future quarterly principal payments and a final payment of $3.03
million for the Loan Agreement due in January 2021.
(3)
Interest on long-term debt includes future monthly interest payments for the Loan Agreement based on a fixed rate of 8.25%. Interest on long-term debt
also includes quarterly interest payments on the Royalty-backed Loan, which bears interest at a per annum rate of 8.75% plus the three-month LIBOR
rate. The three-month LIBOR rate is subject to a floor of 0.7% and a cap of 1.5%. Future interest obligations for the Royalty-backed Loan were
estimated using rates in effect as of December 31, 2018.
(4)
Includes minimum lease payments related to leases of our office and research facilities and certain autos under non-cancelable operating leases.
41
(5) We have contracted with third-party manufacturers for the supply of bulk rHuPH20 and fill/finish of Hylenex
recombinant. Under these agreements, we
are required to purchase certain quantities each year during the terms of the agreements. The amounts presented represent our estimates of the minimum
required payments under these agreements.
Contractual obligations for purchases of goods or services include agreements that are enforceable and legally binding to us and that specify all significant
terms, including fixed or minimum quantities to be purchased; fixed, minimum or variable price provisions; and the approximate timing of the transaction. For
obligations with cancellation provisions, the amounts included in the preceding table were limited to the non-cancelable portion of the agreement terms or the
minimum cancellation fee.
For certain restricted stock units and performance stock units granted, the number of shares issued on the date the restricted stock units vest is net of the
minimum statutory withholding requirements that we pay in cash to the appropriate taxing authorities on behalf of our employees. The obligation to pay the
relevant taxing authority is not included in the preceding table, as the amount is contingent upon continued employment. In addition, the amount of the obligation
is unknown, as it is based in part on the market price of our common stock when the awards vest.
The expected timing of payments of the obligations above is estimated based on current information. Timing of payments and actual amounts paid may be
different, depending on the time of receipt of goods or services, or changes to agreed-upon amounts for some obligations.
Our future capital uses and requirements depend on numerous forward-looking factors. These factors may include, but are not limited to, the following:
•
•
•
•
•
•
•
•
•
•
•
the rate of progress and cost of research and development activities;
the number and scope of our research and development activities;
the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights;
our ability to establish and maintain product discovery and development collaborations, including scale-up manufacturing costs for our collaborators’ product
candidates;
the amount of royalties and milestones from our collaborators;
the amount of product sales for Hylenex
recombinant;
the costs of obtaining and validating additional manufacturers of rHuPH20;
the effect of competing technological and market developments;
the costs of preparing for and launching a new commercial product;
the terms and timing of any collaborative, licensing and other arrangements that we may establish; and
the extent to which we acquire or in-license new products, technologies or businesses.
Critical Accounting Estimates
The discussion and analysis of our financial condition and results of operations are based on our consolidated financial statements, which have been prepared
in accordance with U.S. generally accepted accounting principles, or U.S. GAAP. The preparation of our consolidated financial statements requires us to make
estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses and related disclosure of contingent assets and liabilities. We
review our estimates on an ongoing basis. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable under
the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these
estimates under different assumptions or conditions. Our significant accounting policies are outlined in Note 2 to the Consolidated Financial Statements included in
the Form 10-K. We believe the following accounting policies to be critical to the judgments and estimates used in the preparation of our consolidated financial
statements.
Revenue Recognition
42
Methodology
Judgment and Uncertainties
Effect if Actual Results Differ From Assumptions
For collaborative agreements, we are entitled to receive
event-based payments subject to the collaboration
partner's achievement of specified development and
regulatory milestones. We recognize revenue when it is
deemed probable that these milestones will be achieved,
which could be in a period prior to its actual occurrence.
At the end of each reporting period, we re-evaluate the
probability of achievement of such milestones, and if
necessary, adjust our estimate of the overall transaction
price.
For collaborative agreements, royalty revenue is
recognized in the period the underlying sales occur, but
we do not receive final royalty reports from our
collaboration partners until after we complete our
financial statements for a prior quarter. Therefore, we
recognize revenue based on estimates of the royalty
earned, which are based on preliminary reports provided
by our collaboration partners.
For collaborative arrangements, when necessary, we
perform an allocation of the upfront amount based on
relative stand-alone selling prices (SSP) of licenses for
individual targets. We determine
license SSP using an income-based valuation approach
utilizing risk-adjusted discounted cash flow projections.
Revenue is recognized when we determine it is
probable a milestone will be achieved. This
assessment is based on our past experience with
our collaboration partners, market insight and
partner communication.
A revenue reversal will be required in the event it
is determined that achievement of a milestone,
previously deemed probable, will not occur. This
reversal may be material.
The amount of royalty revenue recognized for
the quarter is estimated using our knowledge of
past royalty payments, market insight and an
estimate made by our collaboration partners
provided in a preliminary report.
A final royalty report and associated royalty
payment is received approximately 60 days after
quarter-end. If necessary, a true-up is recorded at
that time if there is a difference from the initial
estimated royalty revenue recorded. To date, the
true-up entries have not been material.
The inputs used in the valuation model to
determine SSP are based on estimates utilizing
market data and information provided by our
collaboration partners.
Differences in the allocation of the transaction
price between delivered and undelivered
performance obligations can impact the timing of
revenue recognition but do not change the total
revenue recognized under any agreement.
43
Debt Classification
Methodology
Judgment and Uncertainties
Effect if Actual Results Differ From Assumptions
The short-term and long-term classification of
outstanding debt represents our best estimate of the
timing of the amounts to be repaid. These estimates are
based on contractual obligations, anticipated timing of
royalty payments received and changes in LIBOR interest
rates.
Royalty payments are estimated using partner
insight to the marketplace, historical trends and
our knowledge of the therapeutic space.
The short-term and long-term portion of the debts
may change and the repayment term may be
shortened or extended depending on the actual
level of royalty payments received. The actual
repayment period could vary materially from our
estimate to the extent that royalty payments from
our partners are lower than our current estimates,
which could arise due to factors beyond our
control, such as competitive factors, decreased
market acceptance or a failure by our partners to
successfully commercialize in territories where
regulatory approval has been received.
Currently, we do not believe that we have
significant amount of risk relative to the repayment
of the debt. A 10% reduction in the amount of
anticipated royalties would not change our
expected repayment period at maximum
contractual interest rates.
Share-Based Payments
Methodology
Judgment and Uncertainties
Effect if Actual Results Differ From Assumptions
We maintain a Stock Incentive Plan, which provides for
share-based payment awards, including stock options,
restricted stock and performance awards. We determine
the fair value of our stock option awards and performance
awards at the date of grant using a Black-Scholes model.
We determine the fair value of our restricted stock awards
at the date of grant using the closing market value of our
common stock on the date of grant.
Option-pricing models and generally accepted
valuation techniques require management to
make assumptions and to apply judgment to
determine the fair value of our awards. These
assumptions and judgments include estimating
the future volatility of our stock price, expected
dividend yield and future employee stock
option exercise behaviors. Changes in these
assumptions can materially affect the fair value
estimate.
Our performance awards require management
to make assumptions regarding the likelihood of
achieving long-term Company goals.
We do not currently believe there is a reasonable
likelihood that there will be a material change in
estimates or assumptions we use to determine
stock-based compensation expense. However, if
actual results are not consistent with our estimates
or assumptions, we may be exposed to changes in
share-based compensation expense that could be
material.
If actual results are not consistent with the
assumptions used, the share-based compensation
expense reported in our financial statements may
not be representative of the actual economic cost
of the share-based compensation. A 10% change in
our share-based compensation expense for the year
ended December 31, 2018 would have affected
pre-tax earnings by approximately $3.6 million in
2018.
44
Research and Development Expenses - Clinical Trial Accruals
Methodology
Judgment and Uncertainties
Effect if Actual Results Differ From Assumptions
All of our clinical trials have been executed with support
from contract research organizations, (CROs), and other
vendors. We accrue costs for clinical trial activities
performed by CROs based upon the estimated amount of
work completed on each trial.
For clinical trial expenses, the significant
factors used in estimating accruals include the
number of patients enrolled, the activities to be
performed for each patient, the number of
active clinical sites, and the duration for which
the patients will be enrolled in the trial. We
monitor patient enrollment levels and related
activities to the extent possible through internal
reviews, correspondence with CROs and review
of contractual terms.
We base our estimates on the best information
available at the time. However, additional
information may become available to us, which
may allow us to make a more accurate estimate in
future periods. If we do not identify costs that we
have begun to incur or if we underestimate or
overestimate the level of services performed or the
costs of these services, our actual expenses could
differ from our estimates. There were no such
significant changes during the years ended
December 31, 2018, 2017 or 2016.
Recent Accounting Pronouncements
Refer to Note 2, Summary
of
Significant
Accounting
Policies
, of our consolidated financial statements for a discussion of recent accounting pronouncements
and their effect, if any, on us.
Item 7A. Quantitative and Qualitative Disclosures About Market Risk
As of December 31, 2018 , our cash equivalents and marketable securities consisted of investments in money market funds, asset-backed securities, U.S.
Treasury securities, corporate debt obligations and commercial paper. These investments were made in accordance with our investment policy which specifies the
categories, allocations, and ratings of securities we may consider for investment. The primary objective of our investment activities is to preserve principal while at
the same time maximizing the income we receive without significantly increasing risk. Some of the financial instruments that we invest in could be subject to
market risk. This means that a change in prevailing interest rates may cause the value of the instruments to fluctuate. For example, if we purchase a security that
was issued with a fixed interest rate and the prevailing interest rate later rises, the value of that security will probably decline. Based on our current investment
portfolio as of December 31, 2018 , we do not believe that our results of operations would be materially impacted by an immediate change of 10% in interest rates.
We do not hold or issue derivatives, derivative commodity instruments or other financial instruments for speculative trading purposes. Further, we do not
believe our cash, cash equivalents and marketable securities have significant risk of default or illiquidity. We made this determination based on discussions with
our investment advisors and a review of our holdings. While we believe our cash, cash equivalents and marketable securities do not contain excessive risk, we
cannot provide absolute assurance that in the future our investments will not be subject to adverse changes in market value. All of our cash equivalents and
marketable securities are recorded at fair market value.
Item 8. Financial Statements and Supplementary Data
Our financial statements are annexed to this report beginning on page F-1.
Item 9. Changes In and Disagreements with Accountants on Accounting and Financial Disclosure
None.
45
Item 9A. Controls and Procedures
Evaluation of Disclosure Controls and Procedures
We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our Exchange Act reports is
recorded, processed, summarized and reported within the timelines specified in the Securities and Exchange Commission’s rules and forms, and that such
information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow
timely decision regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognized that any controls and
procedures, no matter how well designed and operated, can only provide reasonable assurance of achieving the desired control objectives, and in reaching a
reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and
procedures.
Under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, we conducted
an evaluation of our disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934, as
amended. Based on this evaluation, our principal executive officer and our principal financial officer concluded that our disclosure controls and procedures were
effective as of the end of the period covered by this Annual Report on Form 10-K.
Changes in Internal Control Over Financial Reporting
There have been no significant changes in our internal control over financial reporting that occurred during the quarter ended December 31, 2018 that have
materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
Management’s Report on Internal Control Over Financial Reporting
Our management is responsible for establishing and maintaining adequate internal control over financial reporting. Internal control over financial reporting is
defined in Rule 13a-15(f) and Rule 15d-15(f) promulgated under the Exchange Act as a process designed by, or under the supervision of, our principal executive
and principal financial officers and effected by our board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of
financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles and includes those
policies and procedures that:
•
•
•
Pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of our assets;
Provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally
accepted accounting principles, and that receipts and expenditures are being made only in accordance with authorizations of our management and directors;
and
Provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a
material effect on our financial statements.
Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any evaluation of
effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with
the policies or procedures may deteriorate.
Our management assessed the effectiveness of our internal control over financial reporting as of December 31, 2018 . In making this assessment, our
management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control-Integrated
Framework (2013 framework) (the COSO criteria). Based on our assessment, management concluded that, as of December 31, 2018 , our internal control over
financial reporting is effective based on the COSO criteria. The independent registered public accounting firm that audited the consolidated financial statements
that are included in this Annual Report on Form 10-K has issued an audit report on the effectiveness of our internal control over financial reporting as of
December 31, 2018 . The report appears below.
46
The Board of Directors and Stockholders
Halozyme Therapeutics, Inc.
Opinion on Internal Control over Financial Reporting
Report of Independent Registered Public Accounting Firm
We have audited Halozyme Therapeutics, Inc.’s internal control over financial reporting as of December 31, 2018 , based on criteria established in Internal
Control - Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) (the COSO criteria). In our
opinion, Halozyme Therapeutics, Inc. (the Company) maintained, in all material respects, effective internal control over financial reporting as of December 31,
2018 , based on the COSO criteria .
We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the consolidated
balance sheets of the Company as of December 31, 2018 and 2017, and the related consolidated statements of operations, comprehensive (loss) income, cash flows,
and stockholders’ equity (deficit) for each of the three years in the period ended December 31, 2018 , and the related notes and the financial statement schedule
listed in the Index at Item 15(a) and our report dated February 21, 2019 expressed an unqualified opinion thereon.
Basis for Opinion
The Company’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of
internal control over financial reporting included in the accompanying Management’s Report on Internal Control Over Financial Reporting. Our responsibility is to
express an opinion on the Company’s internal control over financial reporting based on our audit. We are a public accounting firm registered with the PCAOB and
are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the
Securities and Exchange Commission and the PCAOB.
We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether effective internal control over financial reporting was maintained in all material respects.
Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and
evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary
in the circumstances. We believe that our audit provides a reasonable basis for our opinion.
Definition and Limitations of Internal Control Over Financial Reporting
A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting
and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over
financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the
transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of
financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in
accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of
unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.
Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of
effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with
the policies or procedures may deteriorate.
/s/ Ernst & Young LLP
San Diego, California
February 21, 2019
47
Item 9B. Other Information
None.
PART III
Item 10. Directors, Executive Officers and Corporate Governance
The information required by this item regarding directors is incorporated by reference to our definitive Proxy Statement (the Proxy Statement) to be filed
with the Securities and Exchange Commission in connection with our 2019 Annual Meeting of Stockholders under the heading “Election of Directors.” The
information required by this item regarding compliance with Section 16(a) of the Securities Exchange Act of 1934, as amended, is incorporated by reference to the
information under the caption “Compliance with Section 16(a) of the Exchange Act” to be contained in the Proxy Statement. The information required by this item
regarding our code of ethics is incorporated by reference to the information under the caption “Code of Conduct and Ethics and Corporate Governance Guidelines”
to be contained in the Proxy Statement. The information required by this item regarding our audit committee is incorporated by reference to the information under
the caption “Board Meetings and Committees—Audit Committee” to be contained in the Proxy Statement. The information required by this item regarding
material changes, if any, to the process by which stockholders may recommend nominees to our board of directors is incorporated by reference to the information
under the caption “Board Meetings and Committees—Nominating and Governance Committee” to be contained in the Proxy Statement.
Executive Officers
Helen
I.
Torley,
M.B. Ch. B., M.R.C.P. (56), President, Chief Executive Officer and Director. Dr. Torley joined Halozyme in January 2014 as President and
Chief Executive Officer and as a member of Halozyme’s Board of Directors. Throughout her career, Dr. Torley has led several successful product launches,
including Kyprolis®, Prolia®, Sensipar®, and Miacalcin®. Prior to joining Halozyme, Dr. Torley served as Executive Vice President and Chief Commercial
Officer for Onyx Pharmaceuticals (Onyx) from August 2011 to December 2013 overseeing the collaboration with Bayer on Nexavar® and Stivarga® and the U.S.
launch of Kyprolis. She was responsible for the development of Onyx's commercial capabilities in ex-US markets and in particular, in Europe. Prior to Onyx, Dr.
Torley spent 10 years in management positions at Amgen Inc., most recently serving as Vice President and General Manager of the US Nephrology Business Unit
from 2003 to 2009 and the U.S. Bone Health Business Unit from 2009 to 2011. From 1997 to 2002, she held various senior management positions at Bristol-Myers
Squibb, including Regional Vice President of Cardiovascular and Metabolic Sales and Head of Cardiovascular Global Marketing. She began her career at
Sandoz/Novartis, where she ultimately served as Vice President of Medical Affairs, developing and conducting post-marketing clinical studies across all
therapeutic areas, including oncology. Dr. Torley serves on the board of directors of Quest Diagnostics Incorporated, a diagnostic information services company.
Within the past five years, Dr. Torley served on the board of directors of Relypsa, Inc., a biopharmaceutical company. Before joining the industry, Dr. Torley was
in medical practice as a senior registrar in rheumatology at the Royal Infirmary in Glasgow, Scotland. Dr. Torley received her Bachelor of Medicine and Bachelor
of Surgery degrees (M.B. Ch.B.) from the University of Glasgow and is a Member of the Royal College of Physicians (M.R.C.P).
Laurie
D.
Stelzer
(51), Senior Vice President, Chief Financial Officer. Ms. Stelzer joined Halozyme in June 2015 as Senior Vice President, Chief Financial
Officer. Prior to joining Halozyme, Ms. Stelzer served from April 2014 to January 2015 as the Senior Vice President of Finance supporting R&D, Technical
Operations and M&A at Shire, Inc., a biopharmaceutical company. Prior to that she was the Division CFO for the Regenerative Medicine Division and the Head of
Investor Relations at Shire from March 2012 to April 2014. Prior to Shire, Ms. Stelzer held positions of increasing responsibility for 15 years at Amgen, Inc., a
biopharmaceutical company, including Interim Treasurer, Head of Emerging Markets Expansion, Executive Director of Global Commercial Finance and Head of
Global Accounting. Early in her career, she held various finance and accounting positions in the real estate and banking industries. Ms. Stelzer serves on the board
of directors of Surface Oncology, Inc., an immuno-oncology company. Ms. Stelzer received her MBA from the Anderson School at the University of California,
Los Angeles, and a Bachelor of Science in Accounting from Arizona State University.
48
Harry
J.
Leonhardt,
Esq.
(62), Senior Vice President, General Counsel and Corporate Secretary. Mr. Leonhardt joined Halozyme in April 2015 as Senior
Vice President, General Counsel, Chief Compliance Officer and Corporate Secretary. Mr. Leonhardt brings more than 30 years of executive management,
corporate legal, intellectual property, compliance, business development and mergers and acquisitions experience to Halozyme, with an extensive background in
the biotechnology industry. Prior to joining Halozyme, Mr. Leonhardt was an arbitrator before the International Centre for Dispute Resolution and a consultant in
the biotechnology industry from January 2013 to April 2015. He served as Senior Vice President, Legal and Compliance, and Corporate Secretary at Amylin
Pharmaceuticals, Inc., a biotechnology company, from September 2011 to January 2013 and previously served in other senior management legal positions at
Amylin since September 2007. Prior to Amylin, he served as Senior Vice President, General Counsel and Corporate Secretary at Senomyx, Inc. from September
2003 to September 2007. From February 2001 to September 2003, Mr. Leonhardt was Executive Vice President, General Counsel and Corporate Secretary at
Genoptix, Inc. and from July 1996 to November 2000, he served as Vice President and then Senior Vice President, General Counsel and Corporate Secretary at
Nanogen, Inc. Prior to Nanogen, Mr. Leonhardt held positions of increasing responsibility at Allergan, Inc. including Chief Litigation Counsel and General
Counsel for European Operations. Early in his career, he was an attorney at Lyon & Lyon LLP where he represented a number of prominent clients in the biotech,
pharmaceutical and consumer products industries. Mr. Leonhardt received a B.S. in Pharmacy from the University of the Sciences and a Juris Doctorate from the
University of Southern California School of Law.
Dimitrios
Chondros
(54), Senior Vice President, Chief Medical Officer. Dr. Chondros joined Halozyme in August 2015 as Vice President of Clinical
Development and has served as Chief Medical Officer since May 2017. Dr. Chondros brings to Halozyme broad experience directing complex clinical
development and companion diagnostic programs toward global regulatory approvals and preparing for market entry. Prior to joining Halozyme, Dr. Chondros
served in positions of increasing responsibility at Genentech Inc., a biotechnology company, from 2009 to 2015. He most recently served as Associate Group
Medical Director and prior to that as Senior Medical Director and Medical Director. While at Genentech, Dr. Chondros was responsible for all global development
activities in gastrointestinal and hematologic malignancies for Avastin®. From 2005 to 2008, Dr. Chondros was at Cell Genesys, Inc., a biotechnology company,
where he most recently served as Medical Director and directed the clinical development of an investigational immunotherapy for prostate cancer. Dr. Chondros
previously served as a Medical Advisor for Grunenthal, a pharmaceutical company, where he was responsible for building the company’s clinical department in the
United States. Dr. Chondros is a medical doctor and a board certified general surgeon. He studied medicine at the RWTH Aachen University in Aachen, Germany
and received his medical degree from the University of Zürich, Switzerland.
Benjamin
J.
Hickey
(44), Senior Vice President, Chief Commercial Officer. Mr. Hickey joined Halozyme in September 2018 as Senior Vice President, Chief
Commercial Officer. Mr. Hickey brings to Halozyme a long track record of leading pharmaceutical commercial teams, including launch teams, for innovative
oncology treatments. Prior to Halozyme, Mr. Hickey served from August 2016 to September 2018 as the General Manager UK & Ireland at Bristol-Myers Squibb,
a global biopharmaceutical company, overseeing an organization of more than 300 people across the virology, immuno-science, oncology and cardiovascular
disease businesses. From March 2014 to August 2016, he served as Vice President Commercial, Immuno-Oncology for Bristol-Myers where he led a commercial
team focused on the commercialization of Yervoy ® and the launch preparedness of Opdivo ® . From 2001 to March 2014, Mr. Hickey held positions of increasing
responsibility at Bristol Myers including Vice President, Hematology & Erbitux. Mr. Hickey received his Bachelor of Science and his Master of Business
Administration degrees from St. Johns University in Queens, New York.
Item 11. Executive Compensation
The information required by this item is incorporated by reference to the information under the caption “ Executive
Compensation
” to be contained in the
Proxy Statement.
Item 12.
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
Other than as set forth below, the information required by this item is incorporated by reference to the information under the caption “ Security
Ownership
of
Certain
Beneficial
Owners
and
Management
and
Related
Stockholder
Matters
” to be contained in the Proxy Statement.
49
Equity Compensation Plan Information
The following table summarizes our compensation plans under which our equity securities are authorized for issuance as of December 31, 2018 :
Plan Category
Equity compensation plans approved by stockholders (1)
Equity compensation plans not approved by stockholders
_____________________
Number of Shares
to be Issued upon
Exercise of
Outstanding Options
and Restricted Stock
Units
(a)
13,400,723
Weighted Average
Exercise Price
of Outstanding
Options (2)
(b)
$13.81
—
13,400,723
—
$13.81
Number of Shares
Remaining Available
for Future Issuance
under Equity
Compensation
Plans (Excluding
Shares Reflected
in Column (a))
(c)
12,299,463
—
12,299,463
(1) Represents stock options, restricted stock units, and performance restricted stock units under the Amended and Restated 2011 Stock Plan, 2008 Stock
Plan and 2006 Stock Plan.
(2) This amount does not include restricted stock units and performance restricted stock units as there is no exercise price for such units.
Item 13. Certain Relationships and Related Transactions, and Director Independence
The information required by this item is incorporated by reference to the information under the caption “ Certain
Relationships
and
Related
Transactions
”
and “Corporate
Governance
-
Director
Independence”
to be contained in the Proxy Statement.
Item 14. Principal Accounting Fees and Services
The information required by this item is incorporated by reference to the information under the caption “ Principal
Accounting
Fees
and
Services
” to be
contained in the Proxy Statement.
Item 15. Exhibits and Financial Statement Schedules
(a)
Documents filed as part of this report.
1. Financial Statements
PART IV
Report of Independent Registered Public Accounting Firm
Consolidated Balance Sheets at December 31, 2018 and 2017
Consolidated Statements of Operations for Each of the Years Ended December 31, 2018, 2017 and 2016
Consolidated Statements of Comprehensive (Loss) Income for Each of the Years Ended December 31, 2018,
2017 and 2016
Consolidated Statements of Cash Flows for Each of the Years Ended December 31, 2018, 2017 and 2016
Consolidated Statements of Stockholders’ Equity for Each of the Years Ended December 31, 2018,
2017 and 2016
Notes to the Consolidated Financial Statements
50
Page
F-1
F-2
F-3
F-4
F-5
F-7
F-8
2. List of all Financial Statement schedules.
The following financial statement schedule of Halozyme Therapeutics, Inc. is filed as part of this Annual Report on Form 10-K and should be read in
conjunction with the consolidated financial statements of Halozyme Therapeutics, Inc.
Schedule II: Valuation and Qualifying Accounts
Page
F-42
All other schedules are omitted because they are not applicable or the required information is shown in the Financial Statements or notes thereto.
3. List of Exhibits required by Item 601 of Regulation S-K. See part (b) below.
51
(b)
Exhibits.
Exhibit
Number
3.1
3.2
10.1
10.2
10.3#
10.4#
10.5#
10.6#
10.7#
10.8#
10.9#
10.14#
10.15#
10.16#
Exhibit Title
Filed
Herewith
Composite Certification of Incorporation
Bylaws, as amended
License Agreement between University of Connecticut and Registrant, dated November
15, 2002
Incorporated by Reference
Form
10-Q
8-K
File No.
Date Filed
001-32335
8/7/2013
001-32335
12/19/2016
SB-2
333-114776
4/23/2004
First Amendment to the License Agreement between University of Connecticut and
Registrant, dated January 9, 2006
8-K
001-32335
1/12/2006
Halozyme Therapeutics, Inc. 2008 Stock Plan
Form of Stock Option Agreement (2008 Stock Plan)
Form of Restricted Stock Agreement (2008 Stock Plan)
Halozyme Therapeutics, Inc. 2011 Stock Plan (as amended through May 2, 2018)
Form of Stock Option Agreement (2011 Stock Plan)
Form of Stock Option Agreement for Executive Officers (2011 Stock Plan)
Form of Restricted Stock Units Agreement for Officers (2011 Stock Plan)
10.10#
Form of Restricted Stock Award Agreement for Officers (2011 Stock Plan)
10.11#
Form of Restricted Stock Units Agreement (2011 Stock Plan)
10.12#
Form of Restricted Stock Award Agreement (2011 Stock Plan)
10.13#
Form of Stock Option Agreement (2011 Stock Plan -grants made on or after 11/4/2015)
Form of Restricted Stock Units Agreement (2011 Stock Plan - grants made on or after
11/4/2015)
8-K
10-Q
10-Q
8-K
8-K
8-K
10-Q
10-Q
8-K
8-K
10-Q
10-Q
001-32335
3/19/2008
001-32335
8/7/2009
001-32335
8/7/2009
001-32335
4/6/2018
001-32335
5/6/2011
001-32335
5/6/2011
001-32335
8/10/2015
001-32335
8/10/2015
001-32335
5/6/2011
001-32335
5/6/2011
001-32335
11/9/2015
001-32335
11/9/2015
Form of Restricted Stock Award Agreement (2011 Stock Plan - grants made on or after
11/4/2015)
10-Q
001-32335
11/9/2015
Form of Restricted Stock Units Agreement (2011 Plan - grants made on or after
2/22/2017)
10-K
001-32335
2/28/2017
10.17#
Form of Indemnity Agreement for Directors and Executive Officers
8-K
001-32335
12/20/2007
52
10.20
10.21
10.22
10.23
10.24
10.25
10.26
10.27
10.27
Exhibit
Number
10.18#
Severance Policy
Exhibit Title
Filed
Herewith
10.19#
Form of Amended and Restated Change In Control Agreement with Officer
Lease (11404 and 11408 Sorrento Valley Road), effective as of June 10, 2011
First Amendment to Lease (11404 and 11408 Sorrento Valley Road), dated June 30,
2017
Incorporated by Reference
Form
8-K
10-Q
8-K
8-K
File No.
Date Filed
001-32335
12/13/2018
001-32335
11/9/2015
001-32335
6/16/2011
001-32335
7/5/2017
Second Amendment to Lease (11404 and 11408 Sorrento Valley Road), dated March
23, 2018
10-Q
001-32335
5/10/2018
Amended and Restated Lease (11388 Sorrento Valley Road), effective as of June 10,
2011
8-K
001-32335
6/16/2011
First Amendment to Amended and Restated Lease (11388 Sorrento Valley Road), dated
June 30, 2017
8-K
001-32335
7/5/2017
Second Amendment to Amended and Restated Lease (11388 Sorrento Valley Road),
dated March 23, 2018
10-Q
001-32335
5/10/2018
Lease (11436 Sorrento Valley Road), effective as of April 2013
First Modification to Lease (11436 Sorrento Valley Road)
Second Modification to Lease (11436 Sorrento Valley Road), dated June 30, 2017
10.29*
Credit Agreement, dated December 30, 2015
10-K
10-Q
8-K
10-K
001-32335
3/1/2013
001-32335
5/8/2013
001-32335
7/5/2017
001-32335
2/29/2016
10.30#
Halozyme Therapeutics, Inc. Executive Incentive Plan
DEF-14A
001-32335
3/23/2016
10.31
10.32
10.33
21.1
23.1
31.1
31.2
Loan and Security Agreement, dated June 7, 2016
Consent, Release, and First Amendment to Loan and Security Agreement, dated
December 21, 2016
Consent, Release, and Second Amendment to Loan and Security Agreement, dated
November 21, 2017
Subsidiaries of Registrant
Consent of Independent Registered Public Accounting Firm
Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the
Securities Exchange Act of 1934, as amended
Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the
Securities Exchange Act of 1934, as amended
X
X
X
X
53
10-Q
10-K
001-32335
8/9/2016
001-32335
2/28/2017
10-K
001-32335
2/20/2018
Exhibit
Number
32
Exhibit Title
Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18
U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS
XBRL Instance Document
101.SCH
XBRL Taxonomy Extension Schema
101.CAL
XBRL Taxonomy Extension Calculation Linkbase
101.DEF
XBRL Taxonomy Extension Definition Linkbase
101.LAB
XBRL Taxonomy Extension Label Linkbase
101.PRE
_______________
XBRL Taxonomy Presentation Linkbase
Incorporated by Reference
Filed
Herewith
Form
File No.
Date Filed
X
X
X
X
X
X
X
*
#
Confidential treatment has been granted (or requested) for certain portions of this exhibit. These portions have been omitted from this agreement and
have been filed separately with the Securities and Exchange Commission.
Indicates management contract or compensatory plan or arrangement.
(c)
Financial Statement Schedules. See Item 15(a) 2 above.
Item 16. Form 10-K Summary
None.
54
SIGNATURES
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its
behalf by the undersigned, thereunto duly authorized.
Date:
February 21, 2019
Halozyme Therapeutics, Inc.,
a Delaware corporation
By:
/s/ Helen I. Torley, M.B. Ch.B., M.R.C.P.
Helen I. Torley, M.B. Ch.B., M.R.C.P.
President and Chief Executive Officer
55
POWER OF ATTORNEY
Know all persons by these presents, that each person whose signature appears below constitutes and appoints Helen I. Torley and Laurie D. Stelzer, and each
of them, as his/her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him/her and in his/her name, place, and stead,
in any and all capacities, to sign any and all amendments to this Annual Report, and to file the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and
perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he/she might or could do in
person, hereby ratifying and confirming that all said attorneys-in-fact and agents, or any of them or their or his/her substitute or substituted, may lawfully do or
cause to be done by virtue thereof.
Pursuant to the requirements of the Securities Exchange Act of 1934, this Annual Report has been signed below by the following persons on behalf of the
Registrant and in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Helen I. Torley, M.B. Ch.B., M.R.C.P.
Helen I. Torley, M.B. Ch.B., M.R.C.P.
President and Chief Executive Officer
February 21, 2019
(Principal Executive Officer), Director
/s/ Laurie D. Stelzer
Laurie D. Stelzer
/s/ Connie L. Matsui
Connie L. Matsui
/s/ Jean-Pierre Bizzari
Jean-Pierre Bizzari
/s/ Bernadette Connaughton
Bernadette Connaughton
/s/ James M. Daly
James M. Daly
/s/ Jeffrey W. Henderson
Jeffrey W. Henderson
/s/ Kenneth J. Kelley
Kenneth J. Kelley
/s/ Matthew L. Posard
Matthew L. Posard
Senior Vice President and Chief Financial Officer
February 21, 2019
(Principal Financial and Accounting Officer)
Chair of the Board of Directors
February 21, 2019
Director
Director
Director
Director
Director
Director
56
February 21, 2019
February 21, 2019
February 21, 2019
February 21, 2019
February 21, 2019
February 21, 2019
Report of Independent Registered Public Accounting Firm
The Board of Directors and Stockholders
Halozyme Therapeutics, Inc.
Opinion on the Financial Statements
We have audited the accompanying consolidated balance sheets of Halozyme Therapeutics, Inc. (the Company) as of December 31, 2018 and 2017 , and the
related consolidated statements of operations, comprehensive (loss) income, stockholders’ equity (deficit) and cash flows for each of the three years in the period
ended December 31, 2018 , and the related notes and the financial statement schedule listed in the Index at Item 15(a) (collectively referred to as the “consolidated
financial statements”). In our opinion, the consolidated financial statements referred to above, present fairly, in all material respects, the financial position of the
Company at December 31, 2018 and 2017 , and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2018 ,
in conformity with U.S. generally accepted accounting principles.
We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the Company’s
internal control over financial reporting as of December 31, 2018 , based on criteria established in Internal Control - Integrated Framework issued by the
Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) and our report dated February 21, 2019 expressed an unqualified opinion
thereon.
Adoption of ASU No. 2014-09
As discussed in Note 2 to the consolidated financial statements, the Company changed its method for recognizing revenue as a result of the adoption of
Accounting Standards Update (ASU) No. 2014-09, Revenue
from
Contracts
with
Customers
(Topic 606), and the amendments in ASUs 2015-14, 2016-08, 2016-10
and 2016-12 effective January 1, 2018.
Basis for Opinion
These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial
statements based on our audits. We are a public accounting firm registered with the PCAOB and are required to be independent with respect to the Company in
accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.
We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. Our audits included performing procedures to
assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such
procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the
accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe
that our audits provide a reasonable basis for our opinion.
We have served as the Company’s auditor since 2006.
/s/ Ernst & Young LLP
San Diego, California
February 21, 2019
F-1
HALOZYME THERAPEUTICS, INC.
CONSOLIDATED BALANCE SHEETS
(In thousands, except per share amounts)
ASSETS
Current assets:
Cash and cash equivalents
Marketable securities, available-for-sale
Accounts receivable, net
Inventories
Prepaid expenses and other assets
Total current assets
Property and equipment, net
Prepaid expenses and other assets
Restricted cash
Total assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable
Accrued expenses
Deferred revenue, current portion
Current portion of long-term debt, net
Total current liabilities
Deferred revenue, net of current portion
Long-term debt, net
Other long-term liabilities
Commitments and contingencies (Note 9)
Stockholders’ equity:
Preferred stock - $0.001 par value; 20,000 shares authorized; no shares
issued and outstanding
Common stock - $0.001 par value; 200,000 shares authorized; 144,725 and
142,789 shares issued and outstanding at December 31, 2018 and 2017,
respectively
Additional paid-in capital
Accumulated other comprehensive loss
Accumulated deficit
Total stockholders’ equity
Total liabilities and stockholders’ equity
See accompanying notes to consolidated financial statements.
F-2
December 31,
2018
December 31,
2017
$
57,936
$
296,590
30,005
22,625
20,693
427,849
7,465
4,434
500
168,740
300,474
22,133
5,146
13,879
510,372
3,520
5,553
500
$
440,248
$
519,945
$
4,079
$
49,529
4,247
91,506
149,361
5,008
34,874
2,118
7,948
39,601
6,568
77,211
131,328
54,297
125,140
814
—
—
145
780,457
(277)
(531,438)
248,887
$
440,248
$
143
731,044
(450)
(522,371)
208,366
519,945
HALOZYME THERAPEUTICS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS
(In thousands, except per share amounts)
Revenues:
Royalties
Product sales, net
Revenues under collaborative agreements
Total revenues
Operating expenses:
Cost of product sales
Research and development
Selling, general and administrative
Total operating expenses
Operating (loss) income
Other income (expense):
Investment and other income, net
Interest expense
(Loss) income before income taxes
Income tax expense (benefit)
Net (loss) income
Net (loss) income per share:
Basic
Diluted
Shares used in computing net (loss) income per share:
Basic
Diluted
Year Ended December 31,
2018
2017
2016
$
78,981
$
63,507
$
28,234
44,647
151,862
10,136
150,252
60,804
221,192
(69,330)
7,578
(18,041)
(79,793)
537
50,396
202,710
316,613
31,152
150,643
53,816
235,611
81,002
2,592
(21,984)
61,610
(1,361)
50,984
53,392
42,315
146,691
33,206
150,842
45,853
229,901
(83,210)
1,326
(19,977)
(101,861)
1,162
$
(80,330)
$
62,971
$
(103,023)
$
$
(0.56)
(0.56)
$
$
0.46
0.45
$
$
(0.81)
(0.81)
143,599
143,599
136,419
139,068
127,964
127,964
See accompanying notes to consolidated financial statements.
F-3
HALOZYME THERAPEUTICS, INC.
CONSOLIDATED STATEMENTS OF COMPREHENSIVE (LOSS) INCOME
(In thousands)
Net (loss) income
Other comprehensive (loss) income:
Unrealized gain (loss) on marketable securities
Foreign currency translation adjustment
Unrealized loss on foreign currency
Total comprehensive (loss) income
Year Ended December 31,
2018
2017
2016
$
(80,330)
$
62,971
$
(103,023)
182
(8)
(1)
(430)
(14)
—
93
—
—
$
(80,157)
$
62,527
$
(102,930)
See accompanying notes to consolidated financial statements.
F-4
HALOZYME THERAPEUTICS, INC.
CONSOLIDATED STATEMENTS OF CASH FLOWS
(In thousands)
Operating activities:
Net (loss) income
Adjustments to reconcile net (loss) income to net cash (used in) provided by operating
activities:
Share-based compensation
Depreciation and amortization
Non-cash interest expense
Payment-in-kind interest expense on long-term debt
(Accretion of discounts) amortization of premiums on marketable securities, net
Loss on disposal of equipment
Deferral of unearned revenue
Recognition of deferred revenue
Deferral of rent expense
Recognition of deferred rent
Other
Changes in operating assets and liabilities:
Accounts receivable, net
Inventories
Prepaid expenses and other assets
Accounts payable and accrued expenses
Net cash (used in) provided by operating activities
Investing activities:
Purchases of marketable securities
Proceeds from maturities of marketable securities
Purchases of property and equipment
Net cash provided by (used in) investing activities
Financing activities:
Proceeds from issuance of common stock, net
Proceeds from issuance of long-term debt, net
Repayment of long-term debt
Proceeds from issuance of common stock under equity incentive plans, net of taxes paid
related to net share settlement
Net cash (used in) provided by financing activities
Net (decrease) increase in cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
F-5
Year Ended December 31,
2018
2017
2016
$
(80,330)
$
62,971
$
(103,023)
35,696
2,388
1,545
—
(3,090)
5
3,000
(2,832)
—
(7)
(9)
11,613
(17,480)
(5,695)
5,696
(49,500)
(311,112)
318,268
(4,663)
2,493
—
—
(77,516)
13,719
(63,797)
(110,804)
169,240
30,670
2,161
1,761
—
(303)
46
22,759
(6,512)
13
(185)
(16)
(6,453)
9,477
2,035
15,629
134,053
(398,187)
235,805
(1,350)
(163,732)
134,874
—
(15,995)
12,776
131,655
$
101,976
67,264
$
58,436
$
169,240
$
25,585
2,410
2,896
552
13,184
8
701
(9,304)
—
(370)
—
16,730
(5,134)
5,626
(244)
(50,383)
(155,412)
81,783
(3,137)
(76,766)
—
203,006
(54,250)
1,865
150,621
23,472
43,792
67,264
Supplemental disclosure of cash flow information:
Interest paid
Income taxes paid
Supplemental disclosure of non-cash investing and financing activities:
Amounts accrued for purchases of property and equipment
Leasehold improvements paid by lessor
Year Ended December 31,
2018
2017
2016
$
$
$
$
16,891
220
542
1,322
$
$
$
$
20,295
3,015
189
13
$
$
$
$
3,886
1,441
75
—
See accompanying notes to consolidated financial statements.
F-6
HALOZYME THERAPEUTICS, INC.
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY (DEFICIT)
(in thousands)
Common Stock
Amount
Additional
Paid-In
Capital
Accumulated
Other
Comprehensive
Income (Loss)
Accumulated
Deficit
Total
Stockholders’
Equity (Deficit)
128 $
525,628 $
(99)
$
(482,658) $
BALANCE AT JANUARY 1, 2016
Adjustment to beginning retained earnings
Share-based compensation expense
Issuance of common stock pursuant to exercise of stock
options and vesting of restricted stock units, net
Issuance of restricted stock awards, net
Other comprehensive income
Net loss
BALANCE AT DECEMBER 31, 2016
Share-based compensation expense
Issuance of common stock pursuant to exercise of stock
options and vesting of restricted stock units and
performance restricted stock units, net
Cancellation of restricted stock awards, net
Other comprehensive loss
Net income
Shares
128,152 $
—
—
570
780
—
—
129,502
—
1,796
(9)
—
—
—
—
1
1
—
—
130
—
2
—
—
—
(339)
25,585
1,947
(84)
—
—
552,737
30,670
12,774
—
—
—
BALANCE AT DECEMBER 31, 2017
142,789
143
731,044
Adjustment to beginning retained earnings
Share-based compensation expense
Issuance of common stock pursuant to exercise of stock
options and vesting of restricted stock units and
performance restricted stock units, net
Issuance of restricted stock awards, net
Other comprehensive income
Net loss
—
—
1,932
4
—
—
—
—
2
—
—
—
—
35,696
13,717
—
—
—
—
—
—
—
93
—
(6)
—
—
—
(444)
—
(450)
—
—
—
—
173
—
339
—
—
—
—
(103,023)
(585,342)
—
—
—
—
62,971
(522,371)
71,263
—
—
—
(80,330)
42,999
—
25,585
1,948
(83)
93
(103,023)
(32,481)
30,670
12,776
—
(444)
62,971
208,366
71,263
35,696
13,719
—
173
(80,330)
248,887
BALANCE AT DECEMBER 31, 2018
144,725 $
145 $
780,457 $
(277)
$
(531,438) $
See accompanying notes to consolidated financial statements.
F-7
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements
1. Organization and Business
Halozyme Therapeutics, Inc. is a biotechnology company focused on developing and commercializing novel oncology therapies. We are seeking to translate
our unique knowledge of the tumor microenvironment to create therapies that have the potential to improve cancer patient survival. Our research primarily focuses
on human enzymes that alter the extracellular matrix and tumor microenvironment. The extracellular matrix is a complex matrix of proteins and carbohydrates
surrounding the cell that provides structural support in tissues and orchestrates many important biological activities, including cell migration, signaling and
survival. Over many years, we have developed unique technology and scientific expertise enabling us to pursue this target-rich environment for the development of
therapies.
Our proprietary enzymes are used to facilitate the delivery of injected drugs and fluids, potentially enhancing the efficacy and the convenience of other drugs
or can be used to alter tissue structures for potential clinical benefit. We exploit our technology and expertise using a two pillar strategy that we believe enables us
to manage risk and cost by: (1) developing our own proprietary products in therapeutic areas with significant unmet medical needs, with a focus on oncology, and
(2) licensing our technology to biopharmaceutical companies to collaboratively develop products that combine our technology with the collaborators’ proprietary
compounds.
The majority of our approved product and product candidates are based on rHuPH20, our patented recombinant human hyaluronidase enzyme. rHuPH20 is
the active ingredient in our first commercially approved product, Hylenex
® recombinant, and it works by temporarily breaking down hyaluronan (or “HA”), a
naturally occurring carbohydrate that is a major component of the extracellular matrix in tissues throughout the body such as skin and cartilage. We believe this
temporary degradation creates an opportunistic window for the improved subcutaneous delivery of injectable biologics, such as monoclonal antibodies and other
large therapeutic molecules, as well as small molecules and fluids. We refer to the application of rHuPH20 to facilitate the delivery of other drugs or fluids as our
ENHANZE ® Drug Delivery Technology (“ENHANZE”). We license the ENHANZE technology to form collaborations with biopharmaceutical companies that
develop or market drugs requiring or benefiting from injection via the subcutaneous route of administration.
We currently have ENHANZE collaborations with F. Hoffmann-La Roche, Ltd. and Hoffmann-La Roche, Inc. (“Roche”), Baxalta US Inc. and Baxalta
GmbH (now members of the Takeda group of companies, following the acquisition of Shire plc by Takeda Pharmaceutical Company Limited in January 2019)
(“Baxalta”), Pfizer Inc. (“Pfizer”), Janssen Biotech, Inc. (“Janssen”), AbbVie, Inc. (“AbbVie”), Eli Lilly and Company (“Lilly”), Bristol-Myers Squibb Company
(“BMS”), Alexion Pharma Holding (“Alexion”) ARGENX BVBA (“argenx”).We receive royalties from two of these collaborations, including royalties from sales
of one product from the Baxalta collaboration and two products from the Roche collaboration. Future potential revenues from the sales and/or royalties of our
approved products, product candidates, and ENHANZE collaborations will depend on the ability of Halozyme and our collaborators to develop, manufacture,
secure and maintain regulatory approvals for approved products and product candidates and commercialize product candidates.
Our proprietary development pipeline consists primarily of pre-clinical and clinical stage product candidates in oncology. Our lead oncology program is
Pegvorhyaluronidase alfa (PVHA), also referred to as PEGylated recombinant human hyaluronidase (“PEGPH20”), a molecular entity we are developing in
combination with currently approved cancer therapies as a candidate for the systemic treatment of tumors that accumulate HA. We have demonstrated that when
HA accumulates in a tumor, it can cause increased pressure in the tumor, reducing blood flow into the tumor and with that, reduced access of cancer therapies to
the tumor. PEGPH20 has been demonstrated in animal models to work by temporarily degrading HA surrounding cancer cells resulting in reduced pressure and
increased blood flow to the tumor thereby enabling increased amounts of anticancer treatments administered concomitantly gaining access to the tumor. Through
our efforts and efforts of our partners and collaborators, we are currently in Phase 3 clinical testing for PEGPH20 with ABRAXANE ® (nab-paclitaxel) and
gemcitabine in stage IV pancreatic ductal adenocarcinoma (“PDA”) (HALO 109-301), in Phase 1b clinical testing for PEGPH20 with KEYTRUDA ®
(pembrolizumab) in non-small cell lung cancer (HALO 107-101), in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq® (atezolizumab) in patients with
previously treated metastatic PDA, in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq in patients with gastric
F-8
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
cancer and in Phase 1b/2 clinical testing for PEGPH20 with Tecentriq in patients with cholangiocarcinoma and gall bladder cancer (HALO 110-101/MATRIX).
Except where specifically noted or the context otherwise requires, references to “Halozyme,” “the Company,” “we,” “our,” and “us” in these notes to
consolidated financial statements refer to Halozyme Therapeutics, Inc. and its wholly owned subsidiary, Halozyme, Inc., and Halozyme, Inc.’s wholly owned
subsidiaries, Halozyme Holdings Ltd., Halozyme Royalty LLC, Halozyme Switzerland GmbH and Halozyme Switzerland Holdings GmbH.
2. Summary of Significant Accounting Policies
Basis of Presentation
The consolidated financial statements include the accounts of Halozyme Therapeutics, Inc. and our wholly owned subsidiary, Halozyme, Inc., and Halozyme,
Inc.’s wholly owned subsidiaries, Halozyme Holdings Ltd., Halozyme Royalty LLC, Halozyme Switzerland GmbH and Halozyme Switzerland Holdings GmbH.
All intercompany accounts and transactions have been eliminated.
Use of Estimates
The preparation of consolidated financial statements in conformity with U.S. generally accepted accounting principles (“U.S. GAAP”) requires management
to make estimates and assumptions that affect the amounts reported in our consolidated financial statements and accompanying notes. On an ongoing basis, we
evaluate our estimates and judgments, which are based on historical and anticipated results and trends and on various other assumptions that management believes
to be reasonable under the circumstances. By their nature, estimates are subject to an inherent degree of uncertainty and, as such, actual results may differ from
management’s estimates.
Cash Equivalents and Marketable Securities
Cash equivalents consist of highly liquid investments, readily convertible to cash, that mature within ninety days or less from the date of purchase. As of
December 31, 2018 , our cash equivalents consisted of money market funds and commercial paper.
Marketable securities are investments with original maturities of more than ninety days from the date of purchase that are specifically identified to fund
current operations. Marketable securities are considered available-for-sale. These investments are classified as current assets, even though the stated maturity date
may be one year or more beyond the current balance sheet date which reflects management’s intention to use the proceeds from the sale of these investments to
fund our operations, as necessary. Such available-for-sale investments are carried at fair value with unrealized gains and losses recorded in other comprehensive
gain (loss) and included as a separate component of stockholders’ equity (deficit). The cost of marketable securities is adjusted for amortization of premiums or
accretion of discounts to maturity, and such amortization or accretion is included in investment and other income, net in the consolidated statements of operations.
We use the specific identification method for calculating realized gains and losses on marketable securities sold. Realized gains and losses and declines in value
judged to be other-than-temporary on marketable securities, if any, are included in investment and other income, net in the consolidated statements of operations.
Restricted Cash
Under the terms of the leases of our facilities, we are required to maintain letters of credit as security deposits during the terms of such leases. At December
31, 2018 and 2017 , restricted cash of $0.5 million was pledged as collateral for the letters of credit.
Fair Value of Financial Instruments
The authoritative guidance for fair value measurements establishes a three tier fair value hierarchy, which prioritizes the inputs used in measuring fair value.
These tiers include: Level 1, defined as observable inputs such as quoted prices in active markets; Level 2, defined as inputs other than quoted prices in active
markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an
entity to develop its own assumptions.
F-9
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Our financial instruments include cash equivalents, available-for-sale marketable securities, accounts receivable, prepaid expenses and other assets, accounts
payable, accrued expenses and long-term debt. Fair value estimates of these instruments are made at a specific point in time, based on relevant market information.
These estimates may be subjective in nature and involve uncertainties and matters of significant judgment and therefore cannot be determined with precision. The
carrying amount of cash equivalents, accounts receivable, prepaid expenses and other assets, accounts payable and accrued expenses are generally considered to be
representative of their respective fair values because of the short-term nature of those instruments. Based on Level 3 inputs and the borrowing rates currently
available for loans with similar terms, we believe the fair value of long-term debt approximates its carrying value.
Available-for-sale marketable securities consist of asset-backed securities, corporate debt securities, U.S. Treasury securities and commercial paper, and are
measured at fair value using Level 1 and Level 2 inputs. Level 2 financial instruments are valued using market prices on less active markets and proprietary pricing
valuation models with observable inputs, including interest rates, yield curves, maturity dates, issue dates, settlement dates, reported trades, broker-dealer quotes,
issue spreads, benchmark securities or other market related data. We obtain the fair value of Level 2 investments from our investment manager, who obtains these
fair values from a third-party pricing source. We validate the fair values of Level 2 financial instruments provided by our investment manager by comparing these
fair values to a third-party pricing source.
Concentrations of Credit Risk, Sources of Supply and Significant Customers
We are subject to credit risk from our portfolio of cash equivalents and marketable securities. These investments were made in accordance with our
investment policy which specifies the categories, allocations, and ratings of securities we may consider for investment. The primary objective of our investment
activities is to preserve principal while at the same time maximizing the income we receive without significantly increasing risk. We maintain our cash and cash
equivalent balances with one major commercial bank and marketable securities with another financial institution. Deposits held with the financial institutions
exceed the amount of insurance provided on such deposits. We are exposed to credit risk in the event of a default by the financial institutions holding our cash,
cash equivalents and marketable securities to the extent recorded on the consolidated balance sheets.
We are also subject to credit risk from our accounts receivable related to our product sales and revenues under our license and collaborative agreements. We
have license and collaborative agreements with pharmaceutical companies under which we receive payments for license fees, milestone payments for specific
achievements designated in the collaborative agreements, reimbursements of research and development services and supply of bulk formulation of rHuPH20. In
addition, we sell Hylenex
®
recombinant in the United States to a limited number of established wholesale distributors in the pharmaceutical industry. Credit is
extended based on an evaluation of the customer’s financial condition, and collateral is not required. Management monitors our exposure to accounts receivable by
periodically evaluating the collectibility of the accounts receivable based on a variety of factors including the length of time the receivables are past due, the
financial health of the customer and historical experience. Based upon the review of these factors, we recorded no allowance for doubtful accounts at December 31,
2018 and 2017 . Approximately 81% of the accounts receivable balance at December 31, 2018 represents amounts due from Roche and Baxalta. Approximately
86% of the accounts receivable balance at December 31, 2017 represents amounts due from Roche and Baxalta.
The following table indicates the percentage of total revenues in excess of 10% with any single customer:
Roche
Baxalta
BMS
Alexion
Year Ended December 31,
2018
72%
7%
4%
3%
2017
38%
7%
32%
13%
2016
63%
12%
—
—
F-10
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
We attribute revenues under collaborative agreements, including royalties, to the individual countries where the collaborator is headquartered. We attribute
revenues from product sales to the individual countries to which the product is shipped. Worldwide revenues from external customers are summarized by
geographic location in the following table (in thousands):
United States
Switzerland
All other foreign
Total revenues
Year Ended December 31,
2018
2017
2016
$
40,475 $
196,274 $
109,890
1,497
119,136
1,203
$
151,862 $
316,613 $
52,292
93,067
1,332
146,691
As of December 31, 2018 , we had no research equipment in Germany and less than $0.1 million as of December 31, 2017 .
We rely on two third-party manufacturers for the supply of bulk rHuPH20 for use in the manufacture of Hylenex
recombinant and our other collaboration
products and product candidates. Payments due to these suppliers represented 2% and 4% of the accounts payable balance at December 31, 2018 and 2017 ,
respectively. We also rely on a third-party manufacturer for the fill and finish of Hylenex
recombinant product under a contract. Payments due to this supplier
represented 0% and 1% of the accounts payable balance at December 31, 2018 and 2017 , respectively.
Accounts Receivable, Net
Accounts receivable is recorded at the invoiced amount and is non-interest bearing. Accounts receivable is recorded net of allowances for doubtful accounts,
cash discounts for prompt payment, distribution fees and chargebacks. We recorded no allowance for doubtful accounts at December 31, 2018 and 2017 as the
collectibility of accounts receivable was reasonably assured.
Inventories
Inventories are stated at lower of cost or net realizable value. Cost is determined on a first-in, first-out basis. Net realizable value is the estimated selling
price in the ordinary course of business, less reasonably predictable costs of completion, disposal, and transportation. Inventories are reviewed periodically for
potential excess, dated or obsolete status. We evaluate the carrying value of inventories on a regular basis, taking into account such factors as historical and
anticipated future sales compared to quantities on hand, the price we expect to obtain for products in their respective markets compared with historical cost and the
remaining shelf life of goods on hand.
We capitalize inventory costs associated with our drug candidates prior to receipt of regulatory approval, based on management’s judgment of probable
future commercialization. We would be required to expense these capitalized costs upon a change in such judgment, due to, among other factors, a decision
denying approval of the drug candidate by regulatory agencies.
Bulk rHuPH20 formulations manufactured for partner use prior to our partner receiving marketing approval from the U.S. Food and Drug Administration
(“FDA”) or comparable regulatory agencies in foreign countries and with no alternative future use are recorded as research and development expense. All direct
manufacturing costs incurred after the partner receives marketing approval are capitalized as inventory. Bulk rHuPH20 formulations manufactured for general
partner and internal use, which can potentially be used by any collaboration partner or by us in any stage of development or in commercial product, and
ENHANZE drug product used by our partners in clinical trials, is considered to have alternative future use and all manufacturing costs are capitalized as inventory.
Inventories used in our clinical trials are expensed at the time the inventories are packaged for the clinical trials.
As of December 31, 2018 and 2017 , inventories consisted of $2.2 million and $2.9 million , respectively, of Hylenex
recombinant inventory, net, and $20.4
million and $2.2 million , respectively, of bulk rHuPH20.
F-11
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Property and Equipment, Net
Property and equipment are recorded at cost, less accumulated depreciation and amortization. Equipment is depreciated using the straight-line method over
its estimated useful life ranging from three to ten years and leasehold improvements are amortized using the straight-line method over the estimated useful life of
the asset or the lease term, whichever is shorter.
Impairment of Long-Lived Assets
We account for long-lived assets in accordance with authoritative guidance for impairment or disposal of long-lived assets. Long-lived assets are reviewed
for events or changes in circumstances, which indicate that their carrying value may not be recoverable. For the years ended December 31, 2018 and 2017 , there
was no impairment of the value of long-lived assets.
Deferred Rent
Rent expense is recorded on a straight-line basis over the initial term of the lease. The difference between rent expense accrued and amounts paid under lease
agreements is recorded as deferred rent and is included in accrued expenses and other long-term liabilities, as applicable, in the accompanying consolidated balance
sheets.
Comprehensive Income (Loss)
Comprehensive income (loss) is defined as the change in equity during the period from transactions and other events and circumstances from non-owner
sources.
Revenue Recognition
We generate revenues from payments received under collaborative agreements and product sales. As of January 1, 2018, we adopted ASC 606, Revenue
from
Contracts
with
Customers
(ASC 606) which affects how we recognize revenues in these arrangements. We applied the provisions of ASC 606 using the
modified retrospective approach, with the cumulative effect of the adoption recognized as of January 1, 2018, to all contracts that had not been completed as of that
date. Under ASC 606, we recognize revenue when we transfer promised goods or services to customers in an amount that reflects the consideration to which we
expect to be entitled in exchange for those goods or services. To determine revenue recognition for contracts with customers we perform the following five steps:
(i) identify the promised goods or services in the contract; (ii) identify the performance obligations in the contract, including whether they are distinct in the
context of the contract; (iii) determine the transaction price, including the constraint on variable consideration; (iv) allocate the transaction price to the performance
obligations in the contract; and (v) recognize revenue when (or as) we satisfy the performance obligations. Amounts reported in prior periods have not been
adjusted to reflect the adoption of ASC 606. Accordingly, the reported revenue amounts for the year ended December 31, 2018 and the years ended December 31,
2017 and 2016 are based on different accounting policies.
Prior to the ASC 606 adoption, revenue was recognized when all of the following criteria were met: (1) persuasive evidence of an arrangement exists;
(2) delivery has occurred or services have been rendered; (3) the seller’s price to the buyer is fixed or determinable; and (4) collectibility is reasonably assured.
Differences between the revenue recognition policies applicable prior to the adoption and ASC 606 are described in the following sections and in Note 4.
Revenues under Collaborative Agreements - as reported under ASC 606 beginning January 1, 2018
Under these agreements, we grant the collaboration partner a worldwide license to develop and commercialize products using our ENHANZE technology to
combine our patented rHuPH20 enzyme with their proprietary biologics directed at up to a specified number of targets. Targets are usually licensed on an
exclusive, global basis. Targets selected subsequent to inception of the arrangement require payment of an additional license fee. The collaboration partner is
responsible for all development, manufacturing, clinical, regulatory, sales and marketing costs for any products developed under the agreement. We are responsible
for supply of bulk rHuPH20 based on the collaboration partner’s purchase orders, and may also be separately engaged to perform research and development
services.
We collect an upfront license payment from the collaboration partner, and are also entitled to receive event-based payments subject to the collaboration
partner’s achievement of specified development, regulatory and sales-based milestones. In several agreements, collaboration partners pay us annual fees to
maintain their exclusive license rights if they are unable to advance product
F-12
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
development to specified stages. We earn separate fees for bulk rHuPH20 supplies and research and development services. In addition, the collaboration partner
will pay us royalties at an on average mid-single digit percent rate of their sales if products under the collaboration are commercialized. All amounts owed to us are
noncancelable after the underlying triggering event occurs, and nonrefundable once paid. Unless terminated earlier in accordance with its terms, the collaboration
continues in effect until the later of: (i) expiration of the last to expire of the valid claims of our patents covering rHuPH20 or other specified patents developed
under the collaboration which valid claim covers a product developed under the collaboration, and (ii) expiration of the last to expire royalty term for a product
developed under the collaboration, which is determined separately for each country. In the event such valid claims expire prior to the last to expire royalty term, the
royalty rate is reduced for the remaining royalty term following such expiration. The collaboration partner may terminate the agreement prior to expiration for any
reason in its entirety or on a target-by-target basis generally upon 90 days prior written notice to us. Upon any such termination, the license granted to the
collaboration partner (in total or with respect to the terminated target, as applicable) will terminate provided, however, that in the event of expiration of the
agreement, the licenses granted will become perpetual, non-exclusive and fully paid.
Although these agreements are in form structured as collaborative agreements, we concluded for accounting purposes they represent contracts with
customers, and are not subject to accounting literature on collaborative arrangements. This is because we grant to collaboration partners licenses to our intellectual
property, and provide supply of bulk rHuPH20 and research and development services which are all outputs of our ongoing activities, in exchange for
consideration. We do not develop assets jointly with collaboration partners, and do not share in significant risks of their development or commercialization
activities. Accordingly, we concluded our collaborative agreements must be accounted for pursuant to ASC Topic 606, Revenue from Contracts with Customers.
Under all of our collaborative agreements, we have identified licenses to use functional intellectual property as the only performance obligation. The
intellectual property underlying the license is our proprietary ENHANZE® technology which represents application of rHuPH20 to facilitate delivery of drugs or
fluids. The license grants the collaboration partners right to use our intellectual property as it exists on the effective date of the license, because there is no ongoing
development of the ENHANZE technology required. Therefore, we recognize revenue from licenses at the point when the license becomes effective and the
collaboration partner has received access to our intellectual property, usually at the inception of the agreement.
When collaboration partners can select additional targets to add to the licenses granted, we consider these rights to be options. We evaluate whether such
options contain material rights, i.e. have exercise prices that are discounted compared to what we would charge for a similar license to a new collaboration partner.
The exercise price of these options includes a combination of the target selection fees, event-based milestone payments and royalties. When these amounts in
aggregate are not offered at a discount that exceeds discounts available to other customers, we conclude the option does not contain a material right, and we
consider grants of additional licensing rights upon option exercises to be separate contracts (target selection contracts).
We provide standard indemnification and protection of licensed intellectual property for our customers. These provisions are part of assurance that the
licenses meet the agreements representations and are not obligations to provide goods or services.
We also fulfill purchase orders for supply of bulk rHuPH20 and perform research and development services pursuant to projects authorization forms for our
collaboration partners, which represent separate contracts. Additionally, we price our supply of bulk rHuPH20 and research and development services at our
regular selling prices, called standalone selling price or SSP. Therefore, our collaboration partners do not have material rights to order these items at prices not
reflective of SSP. Refer to the discussion below regarding recognition of revenue for these separate contracts.
Transaction price for a contract represents the amount to which we are entitled in exchange for providing goods and services to the customer. Transaction
price does not include amounts subject to uncertainties unless it is probable that there will be no significant reversal of revenue when the uncertainty is resolved.
Apart from the upfront license payment (or target selection fees in the target selection contracts), all other fees we may earn under our collaborative agreements are
subject to significant uncertainties of product development. Achievement of many of the event-based development and regulatory milestones may not be probable
until such milestones are actually achieved. This generally relates to milestones such as obtaining marketing authorization approvals and successful completion of
clinical trials. With respect to other development milestones, e.g. dosing of a first patient in a clinical trial, achievement could be considered probable prior to its
actual occurrence, based on the progress towards commencement of the trial. We do not include any amounts subject to uncertainties into the transaction price until
it is probable that the amount will
F-13
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
not result in a significant reversal of revenue in the future. At the end of each reporting period, we re-evaluate the probability of achievement of such milestones
and any related constraint, and if necessary, adjust our estimate of the overall transaction price.
When target exchange rights are held by collaboration partners, and the amounts attributed to these rights are not refundable, they are included in the
transaction price. However, they are recorded as deferred revenues because we have a potential performance obligation to provide a new target if the exchange
right is exercised. These amounts are recognized in revenue when the right of exchange expires or is exercised.
Because our agreements only have one type of performance obligation (licenses) which are typically all transferred at the same time at agreement inception,
allocation of transaction price often is not required. However, allocation is required when licenses for some of the individual targets are subject to rights of
exchange, because revenue associated with these targets cannot be recognized. We perform an allocation of the upfront amount based on relative SSP of licenses
for individual targets. We determine license SSP using income-based valuation approach utilizing risk-adjusted discounted cash flow projections of the estimated
return a licensor would receive. When amounts subject to uncertainties, such as milestones and royalties, are included in the transaction price, we attribute them to
the specific individual target licenses which generate such milestone or royalty amounts.
We also estimate SSP of bulk rHuPH20 and research and development services, to determine that our collaboration partners do not have material rights to
order them at discounted prices. For supplies of bulk rHuPH20, because we effectively act as a contract manufacturer to our collaboration partners, we estimate
and charge SSP based on the typical contract manufacturer margins consistently with all of our collaborative partners. We determine SSP of research and
development services based on a fully-burdened labor rate. Our rates are comparable to those we observe in other collaborative agreements. We also have a history
of charging similar rates to all of our collaboration partners.
Upfront amounts allocated to licenses to individual targets are recognized as revenue when the license is transferred to the collaboration partner, as discussed
above, if the license is not subject to exchange rights, or when the exchange right expires or is exercised. Development milestones and other fees are recognized in
revenue when they are included in the transaction price, because by that time we have already transferred the related license to the collaboration partner.
Sales-based milestones and royalties cannot be recognized until the underlying sales occur. We do not receive final royalty reports from our collaboration
partners until after we complete our financial statements for a prior quarter. Therefore, we recognize revenue based on estimates of the royalty earned, which are
based on preliminary reports provided by our collaboration partners. We will record a true-up in the following quarter if necessary, when final royalty reports are
received. To date, we have not recorded any material true-ups.
In contracts to provide research and development services, such services represent the only performance obligation. The fees are charged based on hours
worked by our employees and the fixed contractual rate per hour, plus third-party pass-through costs, on a monthly basis. We recognize revenues as the related
services are performed based on the amounts billed, as the collaboration partner consumes the benefit of research and development work simultaneously as we
perform these services, and the amounts billed reflect the value of these services to the customer.
Refer to Note 4 Revenue, for further discussion on our collaborative arrangements.
Prior to the adoption of ASC 606 on January 1, 2018, we recognized upfront amounts received under two of our collaborative agreements straight-line over
the contract term in accordance with the accounting standards that were in effect in 2006-2007, when these collaborative agreements were entered into. In addition,
we recognized royalty revenue in the period when we received final royalty reports from the collaboration partners, in the quarter following the quarter in which
the corresponding sales occurred. There were no other adoption differences in revenue recognized due to the transition from the previously existing authoritative
accounting literature to ASC 606.
F-14
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Product Sales, Net - as reported under ASC 606 beginning January 1, 2018
Hylenex Recombinant
We sell Hylenex
recombinant in the U.S. to wholesale pharmaceutical distributors, who sell the product to hospitals and other end-user customers. Sales to
wholesalers are made pursuant to purchase orders subject to the terms of a master agreement, and delivery of individual packages of Hylenex
recombinant
represent performance obligations under each purchase order. We use a contract manufacturer to produce Hylenex
recombinant and a third-party logistics (3PL)
vendor to process and fulfill orders .
We concluded we are the principal in the sales to wholesalers because we control access to services rendered by both vendors
and direct their activities. We have no significant obligations to wholesalers to generate pull-through sales.
Selling prices initially billed to wholesalers are subject to discounts for prompt payment and subsequent chargebacks when wholesalers sell Hylenex
recombinant at negotiated discounted prices to members of certain group purchasing organizations (“GPOs”) and government programs. We also pay quarterly
distribution fees to certain wholesalers for inventory reporting and chargeback processing, and to GPOs as administrative fees for services and for access to GPO
members. We concluded the benefits received in exchange for these fees are not distinct from our sales of Hylenex
recombinant, and accordingly we apply these
amounts to reduce revenues. Wholesalers also have rights to return unsold product nearing or past the expiration date. Because of the shelf life of Hylenex
recombinant and our lengthy return period, there may be a significant period of time between when the product is shipped and when we issue credits on returned
product.
We estimate the transaction price when we receive each purchase order taking into account the expected reductions of the selling price initially billed to the
wholesaler arising from all of the above factors. We have compiled historical experience and data to estimate future returns and chargebacks of Hylenex
recombinant and the impact of the other discounts and fees we pay. When estimating these adjustments to the transaction price, we reduce it sufficiently to be able
to assert that it is probable that there will be no significant reversal of revenue when the ultimate adjustment amounts are known.
Each purchase order contains only one type of product, and is usually shipped to the wholesaler in a single shipment. Therefore, allocation of the transaction
price to individual packages is not required.
We recognize revenue from Hylenex
recombinant product sales and related cost of sales upon product delivery to the wholesaler location. At that time, the
wholesalers take control of the product as they take title, bear the risk of loss of ownership, and have an enforceable obligation to pay us. They also have the ability
to direct sales of product to their customers on terms and at prices they negotiate. Although wholesalers have product return rights, we do not believe they have a
significant incentive to return the product to us.
Upon recognition of revenue from product sales of Hylenex
recombinant, the estimated amounts of credit for product returns, chargebacks, distribution fees,
prompt payment discounts, and GPO fees are included in sales reserves, accrued liabilities and net of accounts receivable. We monitor actual product returns,
chargebacks, discounts and fees subsequent to the sale. If these amounts differ from our estimates, we make adjustments to these allowances, which are applied to
increase or reduce product sales revenue and earnings in the period of adjustment.
In connection with the orders placed by wholesalers, we incur costs such as commissions to our sales representatives. However, as revenue from product
sales is recognized upon delivery to the wholesaler, which occurs shortly after we receive a purchase order, we do not capitalize these commissions and other costs,
based on application of a practical expedient allowed in ASC 606.
F-15
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Bulk rHuPH20
We sell bulk rHuPH20 to collaboration partners for use in research and development; subsequent to receiving marketing approval, we sell it for use in
collaboration commercial products. Sales are made pursuant to purchase orders subject to the terms of the collaborative agreement, and delivery of units of bulk
rHuPH20 represent performance obligations under each purchase order. We provide a standard warranty that the product conforms to specifications. We use a
contract manufacturer to produce bulk rHuPH20 and have concluded we are the principal in the sales to collaboration partners. The transaction price for each
purchase order of bulk rHuPH20 is fixed based on the cost of production plus a contractual markup, and is not subject to adjustments. Allocation of the transaction
price to individual quantities of the product is usually not required because each order contains only one type of product.
We recognize revenue from the sale of bulk rHuPH20 as product sales and related cost of sales upon transfer of title to our partners. At that time, the partners
take control of the product, bear the risk of loss of ownership, and have an enforceable obligation to pay us.
There were no differences in how the previously existing authoritative accounting literature applied to our product sales transactions.
ENHANZE Drug Product
We sell ENHANZE drug product to collaboration partners for use in research and development in early phase clinical studies. Sales are made pursuant to
purchase orders subject to the terms of the collaborative agreement, and delivery of units of ENHANZE drug product represent performance obligations under each
purchase order. We provide a standard warranty that the product conforms to specifications. We use a contract manufacturer to produce ENHANZE drug product
and we concluded we are the principal in the sales to collaboration partners. The transaction price for each purchase order of ENHANZE drug product is fixed
based on the cost of production plus a contractual markup, and is not subject to adjustments. Allocation of the transaction price to individual quantities of the
product is usually not required because each order contains only one type of product.
We recognize revenue from the sale of ENHANZE drug product as product sales and related cost of sales upon transfer of title to our partners. At that time,
the partners take control of the product, bear the risk of loss of ownership, and have an enforceable obligation to pay us.
There were no differences in how the previously existing authoritative accounting literature applied to our product sales transactions.
Revenue Presentation
In our statements of operations, we report as revenues under collaborative agreements the upfront payments, event-based development and regulatory
milestones and sales milestones. We also include in this category revenues from separate research and development contracts pursuant to project authorization
forms and sales of bulk rHuPH20 that has no alternative future use. We report royalties received from collaboration partners as a separate line in our statements of
operations.
Revenues from sales of Hylenex recombinant, bulk rHuPH20 that has alternative future use and ENHANZE drug product are included in product sales, net.
In footnotes to our financial statements, we provide disaggregated revenue information by type of arrangement (product sales, net, collaborative agreements
and research and development services), and additionally, by type of payment stream received under collaborative agreements (upfront amounts, event-based
development and regulatory milestones and other fees, sales milestones and royalties).
F-16
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Cost of Product Sales
Cost of product sales consists primarily of raw materials, third-party manufacturing costs, fill and finish costs, freight costs, internal costs and manufacturing
overhead associated with the production of Hylenex
recombinant and bulk rHuPH20 and ENHANZE drug product that has alternative future use. Cost of product
sales also consists of the write-down of excess, dated and obsolete inventories and the write-off of inventories that do not meet certain product specifications, if
any. Prior to bulk rHuPH20 and ENHANZE drug product having alternative future use, all costs related to the manufacturing of those products were charged to
research and development expenses in the periods such costs were incurred. During the year ended December 31, 2018, sales of bulk rHuPH20 and ENHANZE
drug product included $2.6 million of cost of sales that were previously expensed as research and development. Of the bulk rHuPH20 and ENHANZE drug product
that has alternative future use on hand as of December 31, 2018, approximately $1.9 million in manufacturing costs were previously recorded as research and
development expenses. We expect to sell this inventory by the end of 2020.
Research and Development Expenses
Research and development expenses include salaries and benefits, facilities and other overhead expenses, external clinical trial expenses, research related
manufacturing services, contract services and other outside expenses. Research and development expenses are charged to operating expenses as incurred when
these expenditures relate to our research and development efforts and have no alternative future uses. When bulk rHuPH20 is manufactured for use in research
and development by us or our partners and the product cannot be redirected for alternative use due to formulation and manufacturing specifications, the
manufacturing costs are recorded as research and development expense. Bulk rHuPH20 that is manufactured for partner use prior to our partner receiving
marketing approval from the FDA or comparable regulatory agencies in foreign countries and meet these specifications is recorded as research and development
expenses. The manufacturing costs of bulk rHuPH20 for the approved collaboration products, Herceptin SC, MabThera SC (RITUXAN HYCELA™ in the U.S.)
and HYQVIA, incurred after the receipt of marketing approvals are capitalized as inventory. Bulk rHuPH20 formulations manufactured for general partner and
internal use, which can potentially be used by any collaboration partner or by us in any stage of development or in commercial products, is considered to have
alternative future use and all manufacturing costs are capitalized as inventory. Inventories used in our clinical trials are expensed at the time the inventories are
packaged for the clinical trials.
We are obligated to make upfront payments upon execution of certain research and development agreements. Advance payments, including nonrefundable
amounts, for goods or services that will be used or rendered for future research and development activities are deferred. Such amounts are recognized as expense as
the related goods are delivered or the related services are performed or such time when we do not expect the goods to be delivered or services to be performed.
Milestone payments that we make in connection with in-licensed technology for a particular research and development project that have no alternative future
uses (in other research and development projects or otherwise) and therefore no separate economic value are expensed as research and development costs at the
time the costs are incurred. We currently have no in-licensed technologies that have alternative future uses in research and development projects or otherwise.
Clinical Trial Expenses
We make payments in connection with our clinical trials under contracts with contract research organizations that support conducting and managing clinical
trials. The financial terms of these agreements are subject to negotiation and vary from contract to contract and may result in uneven payment flows. Generally,
these agreements set forth the scope of work to be performed at a fixed fee, unit price or on a time and materials basis. A portion of our obligation to make
payments under these contracts depends on factors such as the successful enrollment or treatment of patients or the completion of other clinical trial milestones.
Expenses related to clinical trials are accrued based on our estimates and/or representations from service providers regarding work performed, including
actual level of patient enrollment, completion of patient studies and progress of the clinical trials. Other incidental costs related to patient enrollment or treatment
are accrued when reasonably certain. If the amounts we are obligated to pay under our clinical trial agreements are modified (for instance, as a result of changes in
the clinical trial protocol or scope of work to be performed), we adjust our accruals accordingly on a prospective basis. Revisions to our contractual payment
obligations are charged to expense in the period in which the facts that give rise to the revision become reasonably certain.
F-17
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Share-Based Compensation
We record compensation expense associated with stock options, restricted stock awards (“RSAs”), restricted stock units (“RSUs”), and RSUs with
performance conditions (“PRSUs”) in accordance with the authoritative guidance for stock-based compensation. The cost of employee services received in
exchange for an award of an equity instrument is measured at the grant date, based on the estimated fair value of the award, and is recognized as expense on a
straight-line basis over the requisite service period of the award. Share-based compensation expense for an award with a performance condition is recognized when
the achievement of such performance condition is determined to be probable. If the outcome of such performance condition is not determined to be probable or is
not met, no compensation expense is recognized and any previously recognized compensation expense is reversed. Forfeitures are recognized as a reduction of
share-based compensation expense as they occur.
Income Taxes
We provide for income taxes using the liability method. Under this method, deferred income tax assets and liabilities are determined based on the differences
between the financial statement carrying amounts of existing assets and liabilities at each year end and their respective tax bases and are measured using enacted
tax rates in effect for the year in which the differences are expected to affect taxable income. Significant judgment is required by management to determine our
provision for income taxes, our deferred tax assets and liabilities, and the valuation allowance to record against our net deferred tax assets, which are based on
complex and evolving tax regulations throughout the world. Deferred tax assets and other tax benefits are recorded when it is more likely than not that the position
will be sustained upon audit. While we have begun to utilize certain of our net operating losses, we have not yet established a track record of profitability.
Accordingly, valuation allowances have been recorded to reduce our net deferred tax assets to zero , with the exception of the alternative minimum tax ("AMT")
credit carryover of $3.0 million . Under the Tax Cuts and Jobs Act (the “Act”) enacted in December 2017, the AMT credit carryover will either be utilized, or if
unutilized fully refunded in 2022. For all other deferred tax assets the valuation allowance will reduce the net value to zero until such time as we can demonstrate
an ability to realize them.
The Act reduces the U.S. federal corporate tax rate from 35% to 21%. As a result, the Company evaluated and adjusted its deferred tax assets to reflect the
new corporate tax rates as of December 31, 2017. As of December 31, 2018, upon completing its analysis of the Act, the Company believes that its disclosures in
its financial statements as of December 31, 2017 are still accurate.
Net (Loss) Income Per Share
Basic net (loss) income per common share is computed by dividing net (loss) income for the period by the weighted average number of common shares
outstanding during the period, without consideration for common stock equivalents. Outstanding stock options, unvested RSAs, unvested RSUs and unvested
PRSUs are considered common stock equivalents and are only included in the calculation of diluted earnings per common share when net income is reported and
their effect is dilutive. For the years ended December 31, 2018, 2017 and 2016 , approximately 13.8 million , 7.1 million , and 13.8 million shares, respectively, of
outstanding stock options, unvested RSAs, unvested RSUs and unvested PRSUs were excluded from the calculation of diluted net (loss) income per common share
because their effect was anti-dilutive. A reconciliation of the numerators and the denominators of the basic and diluted net (loss) income per common share
computations is as follows (in thousands, except per share amounts):
F-18
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Numerator:
Net (loss) income
Denominator:
Weighted average common shares outstanding for basic
net (loss) income per share
Net effect of dilutive common stock equivalents
Weighted average common shares outstanding for diluted
net (loss) income per share
Net (loss) income per share:
Basic
Diluted
Segment Information
Year Ended December 31,
2018
2017
2016
$
(80,330) $
62,971 $
(103,023)
143,599
136,419
127,964
—
2,649
—
143,599
139,068
127,964
$
$
(0.56) $
(0.56) $
0.46 $
0.45 $
(0.81)
(0.81)
We operate our business in one segment, which includes all activities related to the research, development and commercialization of our proprietary
enzymes. This segment also includes revenues and expenses related to (i) research and development and bulk rHuPH20 manufacturing activities conducted under
our collaborative agreements with third parties and (ii) product sales of Hylenex
recombinant. The chief operating decision-maker reviews the operating results on
an aggregate basis and manages the operations as a single operating segment. Our long-lived assets located in foreign countries had no and minimal book value as
of December 31, 2018 and 2017 , respectively.
F-19
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Adoption and Pending Adoption of Recent Accounting Pronouncements
The following table provides a brief description of recently issued accounting standards, those adopted in the current period and those not yet adopted:
Standard
Description
In January 2016, the FASB
issued ASU 2016-01, Financial
Instruments - Overall;
Recognition and Measurement
of Financial Assets and
Financial Liabilities.
In October 2016, the FASB
issued ASU 2016-16, Income
Taxes; Intra-Entity Transfers of
Assets Other Than Inventory
The new guidance supersedes the guidance to classify equity
securities with readily determinable fair values into different
categories (that is, trading or available-for-sale) and requires
equity securities to be measured at fair value with changes in
the fair value recognized through net income. The new
guidance requires public business entities that are required to
disclose fair value of financial instruments measured at
amortized cost on the balance sheet to measure that fair value
using the exit price notion consistent with Topic 820, Fair
Value Measurement.
The new guidance removes the current requirement to defer
the income tax effects of intercompany transfers of assets
other than inventory (e.g., intangible assets) until the asset has
been sold to an outside party. As a result, the income tax
consequences of an intercompany transfer of assets other than
inventory will be recognized in the current period income
statement rather than being deferred until the assets leave the
consolidated entity.
F-20
Effective Date
January 1, 2018.
Effect on the Financial
Statements or Other Significant Matters
We currently do not hold equity
securities. The adoption did not have
a material impact on our consolidated
financial statements.
January 1, 2018
We adopted the new guidance on
January 1, 2018. The adoption did not
have a material impact on our
consolidated financial statements.
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Effective Date
January 1, 2018.
Effect on the Financial
Statements or Other Significant Matters
We adopted the new guidance on
January 1, 2018 using the modified
retrospective approach. Refer to
Notes 2 “Revenue Recognition” and 4
for additional detail regarding the
impact of this adoption.
Standard
In May 2014, the FASB issued
ASU 2014-09, Revenue from
Contracts with Customers
(Topic 606). In March, April,
May and December 2016, the
FASB issued additional
guidance related to Topic 606.
Description
The new standard will supersede nearly all existing revenue
recognition guidance. Under Topic 606, an entity is required
to recognize revenue upon transfer of promised goods or
services to customers in an amount that reflects the expected
consideration to be received in exchange for those goods or
services. Topic 606 defines a five-step process in order to
achieve this core principle, which may require the use of
judgment and estimates, and also requires expanded
qualitative and quantitative disclosures relating to the nature,
amount, timing and uncertainty of revenue and cash flows
arising from contracts with customers, including significant
judgments and estimates used. The new standard also defines
accounting for certain costs related to origination and
fulfillment of contracts with customers, including whether
such costs should be capitalized.
F-21
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Standard
In February 2016, the FASB
issued ASU 2016-02, Leases
(Topic 842). In July 2018, the
FASB issued additional
guidance related to Topic 842.
Description
The new guidance requires lessees to recognize assets and
liabilities for most leases and provides enhanced disclosures.
Effective Date
January 1, 2019.
Early adoption is
permitted.
In August 2018, the FASB
issued ASU 2018-13, Fair
Value Measurement (Topic
820).
The new guidance removes, modifies and adds to certain
disclosure requirements on fair value measurements in Topic
820, Fair Value Measurement.
January 1, 2020
F-22
Effect on the Financial
Statements or Other Significant Matters
We plan to implement the guidance
on January 1, 2019 using a modified
retrospective transition basis for
leases existing as of the period of
adoption. In order to adopt the new
standard, we will be using available
practical expedients and newly
implemented processes and internal
controls for lease accounting. The
practical expedients allow us to carry
forward our historical assessment of
whether existing agreements are or
contain a lease and the classification
of our existing lease arrangements.
We expect all of our real-estate and
automobile operating lease
commitments will be recognized as
lease liabilities with corresponding
right-of-use assets upon adoption,
resulting in an increase in the assets
and liabilities of the consolidated
balance sheet of approximately $7.2
million using an assumed incremental
borrowing rate of 10.0%. We
anticipate that the adoption will not
have an impact in our consolidated
statements of operations and will not
require recognition of a cumulative-
effect adjustment to the opening
balance of retained earnings in the
period of adoption.
We plan to adopt the new guidance on
January 1, 2020. We do not anticipate
the adoption will have a material
impact on our consolidated financial
position or results of operations.
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Standard
In June 2016, the FASB issued
ASU 2016-13, Financial
Instruments - Credit Losses
(Topic 326), Measurement of
Credit Losses on Financial
Instruments
Description
The standard amends the impairment model by requiring
entities to use a forward-looking approach based on expected
losses to estimate credit losses for most financial assets and
certain other instruments that aren’t measured at fair value
through net income. For available-for-sale debt securities,
entities will be required to recognize an allowance for credit
losses rather than a reduction in carrying value of the asset.
Entities will no longer be permitted to consider the length of
time that fair value has been less than amortized cost when
evaluating when credit losses should be recognized.
3. Fair Value Measurement
Available-for-sale marketable securities consisted of the following (in thousands):
Effective Date
January 1, 2020
Effect on the Financial
Statements or Other Significant Matters
We plan to adopt the new guidance on
January 1, 2020. We do not anticipate
the adoption will have a material
impact on our consolidated financial
position or results of operations.
Asset-backed securities
Corporate debt securities
U.S. Treasury securities
Commercial paper
Corporate debt securities
U.S. Treasury securities
Commercial paper
Amortized Cost
$
39,787 $
57,860 $
84,924
114,273
December 31, 2018
Gross Unrealized
Gains
Gross Unrealized
Losses
Estimated Fair
Value
— $
(40) $
—
—
—
(127)
(87)
—
39,747
57,733
84,837
114,273
296,590
$
296,844 $
— $
(254) $
Amortized Cost
$
117,427 $
66,601
116,882
$
300,910 $
December 31, 2017
Gross Unrealized
Gains
Gross Unrealized
Losses
Estimated Fair
Value
— $
—
—
— $
(235) $
(201)
—
(436) $
117,192
66,400
116,882
300,474
As of December 31, 2018 , 22 available-for-sale marketable securities with a fair market value of $167.3 million were in a gross unrealized loss position of
$0.3 million , all of which had been in such position for less than 12 months. Based on our review of these marketable securities, we believe we had no other-than-
temporary impairments on these securities as of December 31, 2018 , because we do not intend to sell these securities and it is not more-likely-than-not that we
will be required to sell these securities before the recovery of their amortized cost basis.
F-23
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Contractual maturities of available-for-sale debt securities are as follows (in thousands):
Due within one year
After one but within five years
December 31, 2018
December 31, 2017
$
$
Estimated Fair Value
296,590 $
—
296,590 $
213,426
87,048
300,474
The following table summarizes, by major security type, our cash equivalents and available-for-sale marketable securities that are measured at fair value on a
recurring basis and are categorized using the fair value hierarchy (in thousands):
Cash equivalents:
Money market funds
Commercial paper
Available-for-sale marketable
securities:
Asset-backed securities
Corporate debt securities
U.S. Treasury securities
Commercial paper
December 31, 2018
December 31, 2017
Level 1
Level 2
Total estimated
fair value
Level 1
Level 2
Total estimated
fair value
$
57,987 $
— $
57,987
$
142,091 $
— $
142,091
—
—
—
—
15,700
15,700
—
—
84,837
39,747
57,733
—
39,747
57,733
84,837
—
—
66,400
—
117,192
—
—
114,273
114,273
—
116,882
$
142,824 $
211,753 $
354,577
$
208,491 $
249,774 $
—
117,192
66,400
116,882
458,265
There were no transfers between Level 1 and Level 2 of the fair value hierarchy during the year ended December 31, 2018 . We had no instruments that were
classified within Level 3 as of December 31, 2018 and 2017 .
F-24
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
4. Revenue
Our disaggregated revenues were as follows (in thousands):
Royalties
Product sales, net
Sales of bulk rHuPH20
Sales of ENHANZE drug product
Sales of Hylenex
Total product sales, net
Revenues under collaborative agreements:
Upfront license fees
Event-based development milestones and other fees
Sales-based milestones
Research and development services
Total revenues under collaborative agreements
Year Ended December 31,
2018
78,981 $
2017
63,507 $
2016
50,984
$
$
12,729 $
35,246 $
37,235
460
15,045
28,234
—
15,150
50,396
—
16,157
53,392
26,336
172,806
16,000
16,317
—
1,417
2,311
12,170
44,647
202,710
1,406
18,067
1,370
21,472
42,315
Total revenue
$
151,862 $
316,613 $
146,691
During the year ended December 31, 2018 we recognized revenue related to licenses granted to collaboration partners in prior periods in the amount of $95.0
million . This amount represents royalties earned in the current period, development milestones of $6.0 million from Roche, $5.0 million from Alexion, and $5.0
million from BMS. We also recognized revenue of $2.8 million during the year ended December 31, 2018 that had been included in deferred revenues at December
31, 2017. We did not recognize any adjustments to reduce sales reserves and allowances liability related to Hylenex
recombinant sales in prior periods.
Revenue recognized during the years ended December 31, 2017 and 2016 was determined in accordance with the accounting rules applicable prior to the
adoption of ASC 606 on January 1, 2018.
Upon the adoption of ASC 606, we recognized an adjustment to increase our accounts receivable by $19.4 million , decrease deferred revenues by $51.8
million , and decrease accumulated deficit by $71.2 million . The impact of applying the provisions of ASC 606 in the year ended December 31, 2018 was to
decrease revenues by $4.7 million . Under the previously existing authoritative accounting literature, at December 31, 2018 our accounts receivable, net would
have been $19.3 million lower, and our deferred revenue $47.4 million higher, than the amounts reported in our consolidated balance sheet. ASC 606 did not have
an aggregate impact on our net cash used in operating activities, but resulted in offsetting changes in net loss and certain assets and liabilities within net cash used
in operating activities in the consolidated statement of cash flows.
Accounts receivable, net and deferred revenues (contract liabilities) from contracts with customers, including collaboration partners, consisted of the
following (in thousands):
Accounts receivable, net
Deferred revenues
December 31,
2018
December 31,
2017
$
30,005 $
9,255
22,133
60,865
F-25
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
As of December 31, 2018 , the amounts included in the transaction price of our contracts with customers, including collaboration partners, and allocated to
goods and services not yet provided were $9.3 million . This amount has been collected and is reported as deferred revenues. Of the total deferred revenues, $3.0
million represents pre-payment of bulk rHuPH20 that we estimate will be delivered in 2019. Of the remaining deferred revenues, for which the timing of when
these goods and services will be provided is controlled by our customers, $4.0 million can be used by the customers at any time through 2022 and the remaining
$2.3 million at any time through November 2019.
There were no contract assets related to collaborative agreements at December 31, 2018 . While we may become entitled to receive additional event-based
development and regulatory milestones and other fees under our collaborative agreements, which relate to intellectual property licenses granted to collaboration
partners in prior periods, no amounts were probable. The following table presents amounts under our collaborative agreements included in the transaction price (i.e.
cumulative amounts triggered or probable) as of December 31, 2018 (in thousands):
Collaboration partner and agreement date:
Roche (December 2006, September 2017 and October 2018) $
95,000 $
30,000 $
22,000 $
228,780 $
375,780
Upfront
(1)
Development
(2)
Sales
(3)
Royalty
Total
Baxalta (September 2007)
Pfizer (December 2012)
Janssen (December 2014)
AbbVie (June 2015)
Lilly (December 2015)
BMS (September 2017)
Alexion (December 2017)
10,000
14,500
15,250
23,000
33,000
105,000
40,000
3,000
2,000
15,000
6,000
—
5,000
5,000
9,000
24,608
—
—
—
—
—
—
—
—
—
—
—
—
46,608
16,500
30,250
29,000
33,000
110,000
45,000
(1) Upfront and additional target selection fees
(2) Event-based development and regulatory milestone amounts and other fees
(3)
Sales-based milestone amounts
Through December 31, 2018 , our collaboration partners have completed development, obtained marketing authorization approvals for certain indications and
commenced commercialization of the following products:
•
•
Roche, for Herceptin SC in the European Union (“EU”) in August 2013; and MabThera SC in the EU in March 2014 and its equivalent RITUXAN
HYCELA™ in the US in June 2017; and Herceptin SC in Canada in September 2018;
Baxalta, for HYQVIA in the EU and in the US in May 2013.
The remaining targets and products are currently in the process of development by the collaboration partners.
F-26
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
5. Certain Balance Sheet Items
Accounts receivable, net consisted of the following (in thousands):
Accounts receivable from product sales to collaborators
Accounts receivable from revenues under collaborative agreements
Accounts receivable from royalty payments
Accounts receivable from other product sales
Subtotal
Allowance for distribution fees and discounts
Total accounts receivable, net
Inventories consisted of the following (in thousands):
Raw materials
Work-in-process
Finished goods
Total inventories
Prepaid expenses and other assets consisted of the following (in thousands):
Prepaid manufacturing expenses
Prepaid research and development expenses
Other prepaid expenses
Other assets
Total prepaid expenses and other assets
Less long-term portion
Total prepaid expenses and other assets, current
December 31,
2018
December 31,
2017
$
3,717
$
5,499
19,199
2,182
30,597
(592)
$
30,005
$
18,475
2,142
—
2,075
22,692
(559)
22,133
December 31,
2018
December 31,
2017
$
$
735
$
11,430
10,460
22,625
$
377
2,131
2,638
5,146
December 31,
2018
December 31,
2017
$
8,230
$
7,922
2,513
6,462
25,127
4,434
$
20,693
$
2,337
7,793
2,585
6,717
19,432
5,553
13,879
Prepaid manufacturing expenses include raw materials, slot reservation fees and other amounts paid to contract manufacturing organizations. Such amounts
are reclassified to work-in-process inventory as materials are used or the CMO services are complete.
F-27
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Property and equipment, net consisted of the following (in thousands):
Research equipment
Manufacturing equipment
Computer and office equipment
Leasehold improvements
Subtotal
Accumulated depreciation and amortization
Property and equipment, net
December 31,
2018
December 31,
2017
$
9,945
$
3,979
5,211
4,569
23,704
(16,239)
$
7,465
$
9,268
1,702
3,725
2,715
17,410
(13,890)
3,520
Depreciation and amortization expense was approximately $2.4 million , $2.2 million , and $2.4 million for the years ended December 31, 2018, 2017 and
2016 , respectively.
Accrued expenses consisted of the following (in thousands):
December 31,
2018
December 31,
2017
Accrued outsourced research and development expenses
$
21,921
$
Accrued compensation and payroll taxes
Accrued outsourced manufacturing expenses
Other accrued expenses
Total accrued expenses
Less long-term portion
Total accrued expenses, current
Deferred revenue consisted of the following (in thousands):
Collaborative agreements
License fees and event-based payments:
Roche
Other
Product sales
Total deferred revenue
Less current portion
16,604
3,975
7,623
50,123
594
$
49,529
$
$
—
$
2,264
2,264
6,991
9,255
4,247
December 31,
2018
December 31,
2017
18,757
13,384
2,504
5,396
40,041
440
39,601
39,379
15,999
55,378
5,487
60,865
6,568
54,297
Deferred revenue, net of current portion
$
5,008
$
F-28
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
6. Long-Term Debt, Net
Royalty-backed Loan
In January 2016 , through our wholly-owned subsidiary Halozyme Royalty LLC (“Halozyme Royalty”), we received a $150 million loan (the “Royalty-
backed Loan”) pursuant to a credit agreement (the “Credit Agreement”) with BioPharma Credit Investments IV Sub, LP and Athyrium Opportunities II Acquisition
LP (the “Royalty-backed Lenders”). Under the terms of the Credit Agreement, Halozyme Therapeutics, Inc. transferred to Halozyme Royalty the right to receive
royalty payments from the commercial sales of ENHANZE products owed under the Roche Collaboration and Baxalta Collaboration (“Collaboration
Agreements”). The royalty payments from the Collaboration Agreements will be used to repay the principal and interest on the loan (the “Royalty Payments”).
The Royalty-backed Loan bears interest at a per annum rate of 8.75% plus the three-month LIBOR rate . The three-month LIBOR rate is subject to a floor of 0.7%
and a cap of 1.5% . The interest rate as of December 31, 2018 and 2017 was 10.25% .
The Credit Agreement provides that none of the Royalty Payments were required to be applied to the Royalty-backed Loan prior to January 1, 2017, 50% of
the Royalty Payments are required to be applied to the Royalty-backed Loan between January 1, 2017 and January 1, 2018 and thereafter all Royalty Payments
must be applied to the Royalty-backed Loan. However, the amounts available to repay the Royalty-backed Loan are subject to caps of $13.75 million per quarter in
2017, $18.75 million per quarter in 2018, $21.25 million per quarter in 2019 and $22.5 million per quarter in 2020 and thereafter. Amounts available to repay the
Royalty-backed Loan will be applied first to pay interest and second to repay principal on the Royalty-backed Loan. Any accrued interest that is not paid on any
applicable quarterly payment date, as defined, will be capitalized and added to the principal balance of the Royalty-backed Loan on such date. Halozyme Royalty
will be entitled to receive and distribute to Halozyme any Royalty Payments that are not required to be applied to the Royalty-backed Loan or which are in excess
of the foregoing caps.
Because the repayment of the term loan is contingent upon the level of Royalty Payments received, the repayment term may be shortened or extended
depending on the actual level of Royalty Payments. The final maturity date of the Royalty-backed Loan will be the earlier of (i) the date when principal and interest
is paid in full, (ii) the termination of Halozyme Royalty’s right to receive royalties under the Collaboration Agreements, and (iii) December 31, 2050 . Currently,
we estimate that the loan will be repaid in the first quarter of 2020. This estimate could be adversely affected and the repayment period could be extended if future
royalty amounts are less than currently expected. Under the terms of the Credit Agreement, at any time after January 1, 2019, Halozyme Royalty may, subject to
certain limitations, prepay the outstanding principal of the Royalty-backed Loan in whole or in part, at a price equal to 105% of the outstanding principal on the
Royalty-backed Loan, plus accrued but unpaid interest. The Royalty-backed Loan constitutes an obligation of Halozyme Royalty, and is non-recourse to
Halozyme. Halozyme Royalty retains its right to the Royalty Payments following repayment of the loan.
As of December 31, 2018 , we were in compliance with all covenants under the Royalty-backed Loan and there was no material adverse change in our
business, operations or financial condition.
We began making principal and interest payments against the Royalty-backed Loan in the first quarter of 2017 and we recorded accrued interest, which is
included in accrued expenses, of $0.4 million and $0.7 million as of December 31, 2018 and 2017 , respectively.
In connection with the Royalty-backed Loan, we paid the Royalty-backed Lenders a fee of $1.5 million and incurred additional debt issuance costs totaling
$0.4 million , which includes expenses that we paid on behalf of the Royalty-backed Lenders and expenses incurred directly by us. Debt issuance costs and the
lender fee have been netted against the debt as of December 31, 2018 , and are being amortized over the estimated term of the debt using the effective interest
method. For the years ended December 31, 2018 , 2017 and 2016, the Company recognized interest expense, including amortization of the debt discount, related to
the Royalty-backed Loan of $13.1 million , $16.4 million and $14.5 million , respectively. The assumptions used in determining the expected repayment term of
the debt and amortization period of the issuance costs requires that we make estimates that could impact the short- and long-term classification of these costs, as
well as the period over which these costs will be amortized. The outstanding balance of the Royalty-backed Loan as of December 31, 2018 was $85.0 million , net
of unamortized debt discount of $0.3 million .
F-29
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Oxford and SVB Loan and Security Agreement
In June 2016, we entered into a Loan and Security Agreement (the “Loan Agreement”) with Oxford Finance LLC (“Oxford”) and Silicon Valley Bank
(“SVB”) (collectively, the “Lenders”), providing a senior secured loan facility of up to an aggregate principal amount of $70.0 million , comprising a $55.0 million
draw in June 2016 and an additional $15.0 million tranche, which we had the option to draw during the second quarter of 2017 and did not exercise. The initial
proceeds were partially used to pay the outstanding principal and final payment of $4.25 million owed on a previous loan agreement with the Lenders. The
remaining proceeds are being used for working capital and general business requirements. The senior secured loan facility carries a fixed interest rate of 8.25% .
The repayment schedule provides for interest only payments for the first 18 months , followed by consecutive equal monthly payments of principal and interest in
arrears through the maturity date of January 1, 2021 . The Loan Agreement provides for a final payment equal to 5.50% of the initial $55.0 million principal
amount. The final payment is due when the Loan Agreement becomes due or upon the prepayment of the facility. We have the option to prepay the outstanding
balance of the Loan Agreement in full.
In connection with the Loan Agreement, the debt offering costs have been recorded as a debt discount in our consolidated balance sheets which, together with
the final payment and fixed interest rate payments, are being amortized and recorded as interest expense throughout the life of the loan using the effective interest
rate method.
The Loan Agreement is secured by substantially all of the assets of the Company and our subsidiary, Halozyme, Inc., except that the collateral does not
include any equity interests in Halozyme, Inc., any of our intellectual property (including all licensing, collaboration and similar agreements relating thereto), and
certain other excluded assets. The Loan Agreement contains customary representations, warranties and covenants by us, which covenants limit our ability to
convey, sell, lease, transfer, assign or otherwise dispose of certain of our assets; engage in any business other than the businesses currently engaged in by us or
reasonably related thereto; liquidate or dissolve; make certain management changes; undergo certain change of control events; create, incur, assume, or be liable
with respect to certain indebtedness; grant certain liens; pay dividends and make certain other restricted payments; make certain investments; make payments on
any subordinated debt; enter into transactions with any of our affiliates outside of the ordinary course of business or permit our subsidiaries to do the same; and
make any voluntary prepayment of or modify certain terms of the Royalty-backed Loan. In addition, subject to certain exceptions, we are required to maintain with
SVB our primary deposit accounts, securities accounts and commodities, and to do the same for our subsidiary, Halozyme, Inc.
The Loan Agreement also contains customary indemnification obligations and customary events of default, including, among other things, our failure to
fulfill certain of our obligations under the Loan Agreement and the occurrence of a material adverse change which is defined as a material adverse change in our
business, operations, or condition (financial or otherwise), a material impairment of the prospect of repayment of any portion of the loan, a material impairment in
the perfection or priority of the Lender’s lien in the collateral or in the value of such collateral or the occurrence of an event of default under the Royalty-backed
Loan. In the event of default by us under the Loan Agreement, the Lenders would be entitled to exercise their remedies thereunder, including the right to accelerate
the debt, upon which we may be required to repay all amounts then outstanding under the Loan Agreement, which could harm our financial condition.
As of December 31, 2018 , we were in compliance with all covenants under the Loan Agreement and there was no material adverse change in our business,
operations or financial condition.
Interest expense, including amortization of the debt discount, related to the Loan Agreement totaled $4.9 million , $5.5 million and $20.0 million for the
years ended December 31, 2018, 2017 and 2016 , respectively. Accrued interest, which is included in accrued expenses, was $0.3 million and $0.4 million as of
December 31, 2018 and 2017 , respectively. The outstanding term loan balance was $41.4 million as of December 31, 2018 , inclusive of $2.2 million of accretion
of the final payment and net of unamortized debt discount related to offering costs of $0.2 million .
F-30
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Future maturities and interest payments of long-term debt as of December 31, 2018 , are as follows (in thousands):
2019
2020
2021
2022
2023
Total minimum payments
Less amount representing interest
Gross balance of long-term debt
Less unamortized debt discount
Present value of long-term debt
Less current portion of long-term debt
$
100,170
32,908
4,755
—
—
137,833
(10,191)
127,642
(1,262)
126,380
(91,506)
34,874
Long-term debt, less current portion and unamortized debt discount
$
7. Share-based Compensation
We currently grant stock options, restricted stock awards and restricted stock units under the Amended and Restated 2011 Stock Plan (“2011 Stock Plan”),
which wa s approved by the stockholders on May 6, 2016 an d provides for the grant of up to 44.2 million shares of common stock to selected employees,
consultants and non-employee members of our Board of Directors as stock options, stock appreciation rights, restricted stock awards, restricted stock unit awards
and performance awards. The 2011 Stock Plan was approved by the stockholders. Awards are subject to terms and conditions established by the Compensation
Committee of our Board of Directors. During the year ended December 31, 2018 , we granted share-based awards under the 2011 Stock Plan. At December 31,
2018 , 13,400,723 shares were subject to outstanding awards and 12,299,463 shares were available for future grants of share-based awards.
Total share-based compensation expense related to share-based awards was comprised of the following (in thousands):
Research and development
Selling, general and administrative
Share-based compensation expense
Share-based compensation expense by type of share-based award (in thousands):
Stock options
RSAs, RSUs and PRSUs
F-31
Year Ended December 31,
2018
2017
2016
17,220 $
18,476
35,696 $
13,080 $
17,590
30,670 $
11,470
14,115
25,585
Year Ended December 31,
2018
2017
2016
18,742 $
16,954
35,696 $
19,583 $
11,087
30,670 $
16,544
9,041
25,585
$
$
$
$
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Total unrecognized estimated compensation cost by type of award and the weighted-average remaining requisite service period over which such expense is
expected to be recognized (in thousands, unless otherwise noted):
Stock options
RSAs
RSUs
December 31, 2018
Unrecognized
Expense
$
$
$
36,326
1,857
23,604
Remaining
Weighted-Average
Recognition Period
(years)
2.4
0.8
2.0
Cash flows resulting from tax deductions in excess of the cumulative compensation cost recognized for options exercised (excess tax benefits) are classified
as cash inflows provided by financing activities and cash outflows used in operating activities.
Stock
Options.
Options granted under the Plans must have an exercise price equal to at least 100% of the fair market value of our common stock on the date
of grant. The options generally have a maximum contractual term of ten years and vest at the rate of one-fourth of the shares on the first anniversary of the date of
grant and 1/48 of the shares monthly thereafter. Certain option awards provide for accelerated vesting if there is a change in control (as defined in the Plans).
A summary of our stock option award activity as of and for the years ended December 31, 2018, 2017 and 2016 is as follows:
Outstanding at January 1, 2016
Granted
Exercised
Canceled/forfeited
Outstanding at December 31, 2016
Granted
Exercised
Canceled/forfeited
Outstanding at December 31, 2017
Granted
Exercised
Canceled/forfeited
Outstanding at December 31, 2018
Vested and expected to vest at December 31, 2018
Exercisable at December 31, 2018
Shares
Underlying
Stock Options
7,993,192
4,466,306
(413,248)
(955,054)
11,091,196
2,717,614
(1,514,826)
(1,185,518)
11,108,466
2,687,285
(1,489,138)
(1,294,232)
11,012,381
11,012,381
6,351,212
Weighted
Average
Remaining
Contractual
Term (years)
Aggregate
Intrinsic
Value
Weighted
Average Exercise
Price per Share
$13.03
$9.03
$6.88
$12.42
$11.70
$12.60
$9.24
$11.89
$12.24
$18.36
$10.96
$13.01
$13.81
$13.81
$12.71
7.1
7.1
6.1
$25.9 million
$25.9 million
$18.6 million
The weighted average grant date fair values of options granted during the years ended December 31, 2018, 2017 and 2016 were $10.33 per share, $7.86 per
share and $5.36 per share, respectively. The total intrinsic value of options exercised during the years ended December 31, 2018, 2017 and 2016 was
approximately $11.5 million , $10.0 million and $1.4 million , respectively. Cash received from stock option exercises for the years ended December 31, 2018,
2017 and 2016 was approximately $16.3 million , $14.0 million and $2.8 million , respectively.
F-32
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
The exercise price of stock options granted is equal to the closing price of the common stock on the date of grant. The fair value of each option award is
estimated on the date of grant using the Black-Scholes-Merton option pricing model (“Black-Scholes model”). Expected volatility is based on historical volatility
of our common stock. The expected term of options granted is based on analyses of historical employee termination rates and option exercises. The risk-free
interest rate is based on the U.S. Treasury yield for a period consistent with the expected term of the option in effect at the time of the grant. The dividend yield
assumption is based on the expectation of no future dividend payments. The assumptions used in the Black-Scholes model were as follows:
Expected volatility
Average expected term (in years)
Risk-free interest rate
Expected dividend yield
Year Ended December 31,
2018
57.2-70.1%
5.4-5.5
2017
69.8-71.7%
5.6
2016
67.5-71.9%
5.4
2.25-2.96%
1.73-2.13%
1.00-1.90%
—
—
—
Restricted
Stock
Awards
. RSAs are grants that entitle the holder to acquire shares of our common stock at zero cost. The shares covered by a RSA cannot be
sold, pledged, or otherwise disposed of until the award vests and any unvested shares may be reacquired by us for the original purchase price following the
awardee’s termination of service. The RSAs will generally vest at the rate of one-fourth of the shares on each anniversary of the date of grant. Annual grants of
RSAs to the Board of Directors typically vest in approximately one year.
The following table summarizes our RSA activity during the years ended December 31, 2018, 2017 and 2016 :
Unvested at January 1, 2016
Granted
Vested
Forfeited
Unvested at December 31, 2016
Granted
Vested
Forfeited
Unvested at December 31, 2017
Granted
Vested
Forfeited
Unvested at December 31, 2018
Number of
Shares
811,480
968,652
(296,831)
(180,198)
1,303,103
98,945
(514,613)
(108,485)
778,950
67,959
(385,678)
(63,842)
397,389
Weighted
Average
Grant Date
Fair Value
$13.13
$8.41
$12.76
$10.33
$10.09
$14.15
$10.23
$9.62
$10.59
$19.13
$11.73
$10.07
$11.03
The estimated fair value of the RSAs was based on the closing market value of our common stock on the date of grant. The total grant date fair value of
RSAs vested during the years ended December 31, 2018, 2017 and 2016 was approximately $4.5 million , $5.3 million and $3.8 million , respectively. The fair
value of RSAs vested during the years ended December 31, 2018, 2017 and 2016 , was approximately $7.2 million , $6.6 million and $2.5 million , respectively.
F-33
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Restricted
Stock
Units
. A RSU is a promise by us to issue a share of our common stock upon vesting of the unit. The RSUs will generally vest at the rate of
one-fourth of the shares on each anniversary of the date of grant.
The following table summarizes our RSU activity during the years ended December 31, 2018, 2017 and 2016 :
Unvested at January 1, 2016
Granted
Vested
Forfeited
Outstanding at December 31, 2016
Granted
Vested
Forfeited
Outstanding at December 31, 2017
Granted
Vested
Forfeited
Outstanding at December 31, 2018
Weighted
Average
Remaining
Contractual
Term (yrs)
Weighted
Average
Grant Date
Fair Value
$13.49
Aggregate
Intrinsic
Value
$8.17
$12.74
$10.99
$10.16
$12.13
$10.48
$11.11
$11.39
$18.41
$11.58
$14.56
$15.12
1.1
$34.9 million
Number of
Shares
666,214
796,582
(218,279)
(77,948)
1,166,569
1,378,273
(378,406)
(251,261)
1,915,175
1,476,382
(582,449)
(420,766)
2,388,342
The estimated fair value of the RSUs was based on the closing market value of our common stock on the date of grant. The total grant date fair value of
RSUs vested during the years ended December 31, 2018, 2017 and 2016 was approximately $6.7 million , $4.0 million and $2.8 million , respectively. The fair
value of RSUs vested during the years ended December 31, 2018, 2017 and 2016 was approximately $11.0 million , $4.7 million and $2.1 million , respectively.
F-34
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Performance
Restricted
Stock
Units
. A PRSU is a promise by us to issue a share of our common stock upon achievement of a specific performance
condition.
The following table summarizes our PRSU activity during the years ended December 31, 2018, 2017 and 2016 :
Outstanding at January 1, 2016
Granted
Vested
Forfeited
Outstanding at December 31, 2016
Granted
Vested
Forfeited
Outstanding at December 31, 2017
Granted
Vested
Forfeited
Outstanding at December 31, 2018
Number of
Shares
Weighted
Average
Grant Date
Fair Value
309,707
—
(30,037)
(79,415)
200,255
—
—
$9.48
—
$9.49
$9.44
$9.49
—
—
(200,255)
$9.49
—
—
—
—
—
—
—
—
—
—
The estimated fair value of the PRSUs was based on the closing market value of our common stock on the date of grant. The total grant date fair value and
intrinsic value of PRSUs vested during the years ended December 31, 2018, 2017 and 2016 was approximately zero , zero and $0.3 million , respectively.
8. Stockholders’ Equity (Deficit)
In May 2017, we completed an underwritten public offering pursuant to which we sold 11.5 million shares of common stock, including 1.5 million shares
sold pursuant to the full exercise of an option to purchase additional shares granted to the underwriters. All of the shares were offered at a public offering price of
$12.50 per share, generating $134.9 million in net proceeds, after deducting underwriting discounts and commissions and other offering expenses. We will
continue to use the net proceeds from this offering to fund continued development of our PEGPH20 oncology program and for other general corporate purposes.
During the years ended December 31, 2018, 2017 and 2016 , we issued an aggregate of 1,489,138 , 1,514,826 and 413,248 shares of common stock,
respectively, in connection with the exercises of stock options, for net proceeds of approximately $16.3 million , $14.0 million and $2.8 million , respectively. For
the years ended December 31, 2018, 2017 and 2016 , we issued 442,599 , 281,398 and 134,944 shares of common stock, respectively, upon vesting of certain
RSUs for which the RSU holders surrendered 139,850 , 97,008 and 83,335 RSUs, respectively, to pay for minimum withholding taxes totaling approximately $4.2
million , $1.9 million and $0.8 million , respectively. In addition, we issued 4,117 shares of common stock, net of cancellations, canceled 9,540 shares of common
stock, net of issuances and issued 780,066 shares of common stock, net of cancellations in connection with grants of RSAs during the years ended December 31,
2018, 2017 and 2016 , respectively.
F-35
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
9. Commitments and Contingencies
Operating Leases
Our administrative offices and research facilities are located in San Diego, California. We lease an aggregate of approximately 80,000 square feet of office
and research space in five buildings. The leases commenced in June 2011, November 2013 and June 2018 and continue through January 2023 . The leases are
subject to approximately 3.0% annual increases throughout the terms of the leases. We also pay a pro rata share of operating costs, insurance costs, utilities and real
property taxes. We received incentives under the leases, including tenant improvement allowances and reduced or free rent, for which the unamortized deferred
rent balances associated with these incentives was $1.7 million and $0.3 million as of December 31, 2018 and 2017, respectively.
We lease approximately 10,000 square feet of office space for a satellite office located in South San Francisco, California. The lease commenced in
November 2015 and continues through January 2021 . The lease is subject to approximately 3.0% annual increases throughout the term of the lease. We also pay a
pro rata share of operating costs, insurance costs, utilities and real property taxes. We received incentives under the lease, including tenant improvement
allowances and reduced or free rent, for which the unamortized deferred rent balances associated with these incentives was $0.2 million and $0.3 million as of
December 31, 2018 and 2017, respectively.
Additionally, we lease certain office equipment under operating leases. Total rent expense was approximately $2.5 million , $2.3 million and $2.2 million for
the years ended December 31, 2018, 2017 and 2016 , respectively.
Approximate annual future minimum operating lease payments as of December 31, 2018 are as follows (in thousands):
Year:
2019
2020
2021
2022
2023
Total minimum lease payments
Other Commitments
$
Operating
Leases
2,953
2,995
2,557
2,506
112
$
11,123
We have existing supply agreements with contract manufacturing organizations Avid Bioservices, Inc. (“Avid”) and Catalent Indiana LLC (formerly Cook
Pharmica LLC) (“Catalent”) to produce supplies of bulk rHuPH20. Under the terms of the agreements, we are committed to certain minimum annual purchases of
bulk rHuPH20. At December 31, 2018 , we had a $14.6 million minimum purchase obligation in connection with these agreements.
In June 2011, we entered into a services agreement with Patheon for the technology transfer and manufacture of Hylenex
recombinant. At December 31,
2018 , we had a $0.3 million minimum purchase obligation in connection with this agreement.
Contingencies
We have entered into an in-licensing agreement with a research organization, which is cancelable at our option with 90 days written notice. Under the terms
of this agreement, we have received a license to the know-how and technology claimed, in certain patents or patent applications. We are required to pay fees,
milestones and/or royalties on future sales of products employing the technology or falling under claims of a patent, and some of the agreements require minimum
royalty payments. We continually reassess the value of the license agreement. If the in-licensed and research candidate is successfully developed, we may be
required to pay milestone payments of approximately $8.0 million over the life of this agreement in addition to royalties on sales of the affected products. Due to
the uncertainties of the development process, the timing and probability of the remaining milestone and royalty payments cannot be accurately estimated.
F-36
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Legal Contingencies
From time to time, we may be involved in disputes, including litigation, relating to claims arising out of operations in the normal course of our business. Any
of these claims could subject us to costly legal expenses and, while we generally believe that we have adequate insurance to cover many different types of
liabilities, our insurance carriers may deny coverage or our policy limits may be inadequate to fully satisfy any damage awards or settlements. If this were to
happen, the payment of any such awards could have a material adverse effect on our consolidated results of operations and financial position. Additionally, any
such claims, whether or not successful, could damage our reputation and business. We currently are not a party to any legal proceedings, the adverse outcome of
which, in management’s opinion, individually or in the aggregate, would have a material adverse effect on our consolidated results of operations or financial
position.
10.
Income Taxes
The Tax Cuts and Jobs Act (the “Act”) was enacted in December 2017. The Act reduces the U.S. federal corporate tax rate from 35% to 21% . As of
December 31, 2017, the Company remeasured its existing deferred tax balance by recording a provisional benefit of $17.1 million , which was fully offset by a
change in the valuation allowance. As of December 31, 2018, upon completing its analysis of the Act, the Company believes that the disclosures in its financial
statements as of December 31, 2017 are still accurate.
Total (loss) income before income taxes summarized by region were as follows (in thousands):
United States
Foreign
Net (loss) income before income taxes
Year Ended December 31,
2018
2017
2016
$
$
(45,819) $
160,938 $
(33,974)
(99,328)
(79,793) $
61,610 $
6,384
(108,245)
(101,861)
Significant components of our net deferred tax assets/(liabilities) were as follows (in thousands).
December 31,
2018
2017
Deferred tax assets:
Net operating loss carryforwards
Deferred revenue
Research and development and orphan drug credits
Share-based compensation
Alternative minimum tax credit
Interest expense limitation
Other, net
Valuation allowance for deferred tax assets
Deferred tax assets, net of valuation
Deferred tax liabilities:
Depreciation
Total deferred tax liabilities
Net deferred tax asset
$
26,267 $
1,395
106,406
9,541
2,959
1,750
2,452
150,770
(146,953)
3,817
(858)
(858)
$
2,959 $
F-37
32,630
8,815
75,224
7,423
5,532
—
2,270
131,894
(126,189)
5,705
(173)
(173)
5,532
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
A valuation allowance of $147.0 million and $126.2 million has been established to offset the net deferred tax assets as of December 31, 2018 and 2017 ,
respectively, as realization of such assets is uncertain. Under the Act, taxpayers are able to claim a refund of the AMT credit carryover by December 31, 2021.
Accordingly, the recognized deferred tax asset as of December 31, 2018 is the AMT credit carryover that will either be utilized or refunded by December 31, 2021.
Income tax expense was comprised of the following components (in thousands):
Current - federal
Current - state
Deferred - federal
Deferred - state
Year Ended December 31,
2018
2017
2016
$
82 $
4,051 $
1,145
519
(64)
—
120
(5,532)
—
17
—
—
$
537 $
(1,361) $
1,162
The provision for income taxes on earnings subject to income taxes differs from the statutory federal income tax rate due to the following (in thousands):
Year Ended December 31,
2018
2017
2016
Federal income tax expense (benefit) at 21% for 2018 and 34% for 2017 and 2016
$
(16,754) $
20,947 $
State income tax benefit, net of federal income tax impact
(Decrease) increase in valuation allowance
Enactment of the Tax Cuts and Jobs Act
Foreign income subject to tax at other than federal statutory rate
Shared-based compensation
Non-deductible expenses and other
Research and development credits, net
Orphan drug credits, net of federal add back
(4,297)
35,731
—
7,106
425
1,599
(5,210)
(18,063)
930
(77,181)
17,132
33,674
525
5,779
4,162
(7,329)
$
537 $
(1,361) $
(34,633)
(653)
11,252
—
36,803
3,735
698
(1,084)
(14,956)
1,162
At December 31, 2018 , our unrecognized tax benefit and uncertain tax positions were $20.0 million . Of this, $0.2 million of this amount would affect the
effective tax rate and $19.8 million would affect the effective tax rate only in the event the valuation allowance was removed. Of the unrecognized tax benefits, we
do not expect any significant changes to occur in the next 12 months. Interest and/or penalties related to uncertain income tax positions are recognized by us as a
component of income tax expense. For the years ended December 31, 2018, 2017 and 2016 , we recognized an immaterial amount of interest and penalties.
The following table summarizes the activity related to our unrecognized tax benefits (in thousands):
Gross unrecognized tax benefits at beginning of period
$
14,428 $
12,799 $
Increases in tax positions for prior years
Decreases in tax positions for prior years
Increases in tax positions for current year
3,083
—
2,517
—
(2,518)
4,147
Gross unrecognized tax benefits at end of period
$
20,028 $
14,428 $
4,898
5,615
(4,898)
7,184
12,799
Year Ended December 31,
2018
2017
2016
F-38
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
At December 31, 2018 , we had federal, California and other state tax net operating loss carryforwards of approximately $61.3 million , $235.0 million and
$20.2 million , respectively.
The following table shows key expiration dates of the federal and California net operating loss carryforwards (in thousands):
Federal
California
Net Operating Loss
61,259
$
$
255,281
2019
Expires in:
2021 and beyond
61,259
2028 and beyond
—
— $
255,281
— $
—
At December 31, 2018 , we had federal and California research and development tax credit carryforwards of approximately $26.5 million and $17.7 million ,
respectively. The federal research and development tax credits will begin to expire in 2024 unless previously utilized. The California research and development tax
credits will carryforward indefinitely until utilized. Additionally, we had Orphan Drug Credit carryforwards of $81.1 million which will begin to expire in 2035 .
Pursuant to Internal Revenue Code Section 382, the annual use of the net operating loss carryforwards and research and development tax credits could be
limited by any greater than 50% ownership change during any three year testing period. As a result of any such ownership change, portions of our net operating
loss carryforwards and research and development tax credits are subject to annual limitations. We completed an updated Section 382 analysis regarding the
limitation of the net operating losses and research and development credits as of December 31, 2017. Based upon the analysis, we determined that ownership
changes occurred in prior years; however, the annual limitations on net operating loss and research and development tax credit carryforwards will not have a
material impact on the future utilization of such carryforwards.
The Company’s 2015 and 2016 federal returns were selected for audit by the IRS. The audit is currently in process and no adjustments have been proposed.
The Company does not expect any material adjustments as a result of the IRS audit.
We do not provide for U.S. income taxes on the undistributed earnings of our foreign subsidiaries as it is our intention to utilize those earnings in the foreign
operations for an indefinite period of time. At December 31, 2018 and 2017 , there were no undistributed earnings in foreign subsidiaries.
We are subject to taxation in the U.S. and in various state and foreign jurisdictions. Our tax years for 1998 and forward are subject to examination by the
U.S. and California tax authorities due to the carryforward of unutilized net operating losses and research and development credits.
A Swiss subsidiary, Halozyme Switzerland GmbH, was formed during the fourth quarter of 2016 and obtained a tax ruling from Canton of Basel Stadt for its
operations in Switzerland. The tax ruling is dated December 21, 2016, and will continue for a period of ten years, not to extend beyond December 31, 2026. The
combined income tax burden at the federal, cantonal and communal level will not exceed 10% during the period covered by the ruling. As a result of foreign losses
and a full valuation allowance, no net tax benefit was derived for the year ended December 31, 2018 as a result of the tax ruling.
11. Employee Savings Plan
We have an employee savings plan pursuant to Section 401(k) of the Internal Revenue Code. All employees are eligible to participate, provided they meet
the requirements of the plan. We are not required to make matching contributions under the plan. However, we voluntarily contributed to the plan approximately
$1.3 million , $1.2 million and $1.0 million for the years ended December 31, 2018, 2017 and 2016 , respectively.
F-39
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
12. Summary of Unaudited Quarterly Financial Information
The following is a summary of our unaudited quarterly results for the years ended December 31, 2018 and 2017 (in thousands):
2018 (Unaudited):
Total revenues (1)
Gross profit on product sales
Total operating expenses
Net loss
Net loss per share:
Basic
Diluted
Shares used in computing net loss per share:
Basic
Diluted
2017 (Unaudited):
Total revenues (2) (3)
Gross profit on product sales
Total operating expenses
Net (loss) income
Net (loss) income per share:
Basic
Diluted
Shares used in computing net (loss) income per share:
Basic
Diluted
_______________
$
$
$
$
$
$
$
$
$
$
$
$
March 31,
June 30,
September 30,
December 31,
Quarter Ended
30,872 $
3,749 $
54,584 $
35,202 $
3,647 $
55,275 $
25,556 $
5,643 $
51,030 $
(27,461) $
(22,893) $
(27,850) $
(0.19) $
(0.19) $
(0.16) $
(0.16) $
(0.19) $
(0.19) $
60,232
5,059
60,303
(2,126)
(0.01)
(0.01)
142,656
142,656
143,568
143,568
143,949
143,949
144,203
144,203
Quarter Ended
March 31,
June 30,
September 30,
December 31,
29,568 $
3,890 $
57,094 $
33,750 $
4,992 $
59,228 $
(32,897) $
(30,763) $
63,731 $
5,257 $
55,654 $
2,749 $
(0.26) $
(0.26) $
(0.23) $
(0.23) $
0.02 $
0.02 $
189,564
5,105
63,635
123,882
0.87
0.85
128,615
128,615
134,013
134,013
141,190
143,236
141,718
145,633
(1) Revenues for the quarter ended December 31, 2018 included $30.0 million in revenue under a collaborative arrangement from Roche.
(2) Revenues for the quarter ended December 31, 2017 included $101.4 million , $40.0 million and $15.0 million in revenue under collaborative
arrangements from BMS, Alexion and Janssen, respectively.
(3) Revenues for the quarter ended September 30, 2017 included $30.0 million in revenue under collaborative arrangements from Roche.
F-40
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
13. Subsequent Events
In February 2019, we entered into an agreement with argenx for the right to develop and commercialize one exclusive target, the human neonatal Fc receptor
FcRn, which includes argenx's lead asset efgartigimod (ARGX-113), and an option to select two additional targets using our ENHANZE technology for an upfront
payment of $30.0 million . We will receive payments of $10.0 million per target for future target nominations and potential milestone payments of up to $160.0
million per target, subject to the achievement of specific development, regulatory and sales-based milestones. We will receive mid-single digit royalties on sales of
commercialized products.
F-41
Halozyme Therapeutics, Inc.
Notes to Consolidated Financial Statements — (Continued)
Halozyme Therapeutics, Inc.
Schedule II
Valuation and Qualifying Accounts
(in thousands)
For the year ended December 31, 2018
Accounts receivable allowances (1)
For the year ended December 31, 2017
Accounts receivable allowances (1)
For the year ended December 31, 2016
Accounts receivable allowances (1)
_______________
Balance at
Beginning of Period
Additions
Deductions
Balance at End of
Period
$
$
$
559 $
5,988 $
(5,955) $
559 $
4,645 $
(4,645) $
967 $
4,795 $
(5,203) $
592
559
559
(1) Allowances are for chargebacks, prompt payment discounts and distribution fees related to Hylenex
recombinant product sales.
F-42
SUBSIDIARIES OF HALOZYME THERAPEUTICS, INC.
Name of Subsidiary
Halozyme, Inc.
Halozyme Holdings Ltd., a wholly owned subsidiary of Halozyme Switzerland
Holdings GmbH
Halozyme Royalty LLC, a wholly owned subsidiary of Halozyme, Inc.
Halozyme Switzerland GmbH, a wholly owned subsidiary of Halozyme Switzerland
Holdings GmbH
Halozyme Switzerland Holdings GmbH, a wholly owned subsidiary of Halozyme,
Inc.
State or Jurisdiction of
Incorporation or Organization
California
Bermuda
Delaware
Switzerland
Switzerland
EXHIBIT 21.1
Percent
Owned
100%
100%
100%
100%
100%
Consent of Independent Registered Public Accounting Firm
EXHIBIT 23.1
We consent to the incorporation by reference in the following Registration Statements:
(1) Registration Statement (Form S-3 No. 333-216315) of Halozyme Therapeutics, Inc.,
(2) Registration Statement (Form S-8 No. 333-119969) pertaining to the Halozyme Therapeutics, Inc. 2004 Stock Plan and Nonstatutory
Stock Option Agreement with Andrew Kim and Assumed Options Under the Deliatroph Pharmaceuticals, Inc. Amended and Restated 2001
Stock Plan of Halozyme Therapeutics, Inc.,
(3) Registration Statement (Form S-8 No. 333-133829) pertaining to the Halozyme Therapeutics, Inc. 2005 Outside Directors’ Stock Plan
and Halozyme Therapeutics, Inc. 2006 Stock Plan of Halozyme Therapeutics, Inc.,
(4) Registration Statement (Form S-8 No. 333-152914) pertaining to the Halozyme Therapeutics, Inc. 2008 Outside Directors’ Stock Plan
and Halozyme Therapeutics, Inc. 2008 Stock Plan of Halozyme Therapeutics, Inc.,
(5) Registration Statement (Form S-8 No. 333-174013) pertaining to the Halozyme Therapeutics, Inc. 2011 Stock Plan of Halozyme
Therapeutics, Inc.,
(6) Registration Statement (Form S-8 No. 333-188997) pertaining to the Halozyme Therapeutics, Inc. Amended and Restated 2011 Stock
Plan of Halozyme Therapeutics, Inc.;
(7) Registration Statement (Form S-8 No. 333-206279) pertaining to the Halozyme Therapeutics, Inc. Amended and Restated 2011 Stock
Plan of Halozyme Therapeutics, Inc.,
(8) Registration Statement (Form S-8 No. 333-211244) pertaining to the Halozyme Therapeutics, Inc. Amended and Restated 2011 Stock
Plan of Halozyme Therapeutics, Inc., and
(9) Registration Statement (Form S-8 No. 333-224843) pertaining to the Halozyme Therapeutics, Inc. Amended and Restated 2011 Stock
Plan of Halozyme Therapeutics, Inc.
of our reports dated February 21, 2019 , with respect to the consolidated financial statements and schedule of Halozyme Therapeutics, Inc. and the
effectiveness of internal control over financial reporting of Halozyme Therapeutics, Inc. included in this Annual Report (Form 10-K) of Halozyme
Therapeutics, Inc. for the year ended December 31, 2018 .
San Diego, California
February 21, 2019
/s/ Ernst & Young LLP
EXHIBIT 31.1
I, Helen I. Torley, M.B. Ch.B., M.R.C.P., Chief Executive Officer of Halozyme Therapeutics, Inc. certify that:
CERTIFICATION OF CHIEF EXECUTIVE OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
1.
2.
3.
4.
I have reviewed this Annual Report on Form 10-K of Halozyme Therapeutics, Inc.;
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this report;
The Registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange
Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the
Registrant and have:
a)
b)
c)
d)
designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to
ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;
designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;
evaluated the effectiveness of the Registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
disclosed in this report any change in the Registrant’s internal control over financial reporting that occurred during the Registrant’s most recent
fiscal quarter (the Registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to
materially affect, the Registrant’s internal control over financial reporting; and
5.
The Registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the
Registrant’s auditors and the audit committee of the Registrant’s board of directors (or persons performing the equivalent functions):
a)
b)
all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably
likely to adversely affect the Registrant’s ability to record, process, summarize and report financial information; and
any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant’s internal control
over financial reporting.
Dated:
February 21, 2019
/s/ Helen I. Torley, M.B. Ch.B., M.R.C.P.
Helen I. Torley, M.B. Ch.B., M.R.C.P
President and Chief Executive Officer
EXHIBIT 31.2
I, Laurie D. Stelzer, Chief Financial Officer of Halozyme Therapeutics, Inc. certify that:
CERTIFICATION OF CHIEF FINANCIAL OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
1.
2.
3.
4.
I have reviewed this Annual Report on Form 10-K of Halozyme Therapeutics, Inc.;
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this report;
The Registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange
Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the
Registrant and have:
a)
b)
c)
d)
designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to
ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;
designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;
evaluated the effectiveness of the Registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
disclosed in this report any change in the Registrant’s internal control over financial reporting that occurred during the Registrant’s most recent
fiscal quarter (the Registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to
materially affect, the Registrant’s internal control over financial reporting; and
5.
The Registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the
Registrant’s auditors and the audit committee of the Registrant’s board of directors (or persons performing the equivalent functions):
a)
b)
all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably
likely to adversely affect the Registrant’s ability to record, process, summarize and report financial information; and
any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant’s internal control
over financial reporting.
Dated:
February 21, 2019
/s/ Laurie D. Stelzer
Laurie D. Stelzer
Senior Vice President and Chief Financial Officer
CERTIFICATION OF
CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
EXHIBIT 32
In connection with the Annual Report of Halozyme Therapeutics, Inc. (the “Registrant”) on Form 10-K for the fiscal year ended December 31, 2018 , as filed with
the Securities and Exchange Commission on the date hereof (the “Report”), I, Helen I. Torley, M.B. Ch.B., M.R.C.P., Chief Executive Officer of the Registrant,
certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:
(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m); and
(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.
Dated:
February 21, 2019
/s/ Helen I. Torley, M.B. Ch.B., M.R.C.P.
Helen I. Torley, M.B. Ch.B., M.R.C.P.
President and Chief Executive Officer
In connection with the Annual Report of Halozyme Therapeutics, Inc. (the “Registrant”) on Form 10-K for the fiscal year ended December 31, 2018 , as filed with
the Securities and Exchange Commission on the date hereof (the “Report”), I, Laurie D. Stelzer, Chief Financial Officer of the Registrant, certify, pursuant to 18
U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:
(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m); and
(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.
Dated:
February 21, 2019
/s/ Laurie D. Stelzer
Laurie D. Stelzer
Senior Vice President and Chief Financial Officer