La Jolla Pharmaceutical Company
Annual Report 2016

Plain-text annual report

UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON, DC 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2016ORo TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period from to Commission file number: 1-36282 LA JOLLA PHARMACEUTICAL COMPANY(Exact name of registrant as specified in its charter) California 33-0361285(State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number)10182 Telesis Court, 6th Floor, San Diego, CA 92121(Address of principal executive offices, including Zip Code)Registrant’s telephone number, including area code: (858) 207-4264Securities registered pursuant to Section 12(b) of the Act:Title of each class Name of each exchange on which registeredCommon Stock, Par Value $0.0001 per share The NASDAQ Capital MarketSecurities registered pursuant to Section 12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes o No xIndicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes o No xIndicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No oIndicate by check mark whether the registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted andposted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post suchfiles). Yes x No oIndicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrant’sknowledge, in definitive proxy or information statements incorporated by reference in Part III of the Form 10-K or any amendment to this Form 10-K. xIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of“large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):Large accelerated filero Accelerated filerxNon-accelerated filero(Do not check if a smaller reporting company)Smaller reporting companyoIndicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes o No xThe aggregate market value of voting and non-voting common stock held by non-affiliates of the registrant as of June 30, 2016 totaled approximately $220,069,000. As ofFebruary 17, 2017, there were 18,261,557 shares of the Company’s common stock, $0.0001 par value, outstanding.DOCUMENTS INCORPORATED BY REFERENCECertain information required to be disclosed in Part III of this report is incorporated by reference from the registrant’s definitive Proxy Statement for the 2017 AnnualMeeting of Stockholders, which proxy statement is expected to be filed not later than 120 days after the end of the fiscal year covered by this report.TABLE OF CONTENTSPART I Item 1. Business1Item 1A. Risk Factors11Item 1B. Unresolved Staff Comments23Item 2. Properties23Item 3. Legal Proceedings24Item 4. Mine Safety Disclosures24PART II Item 5. Market for Registrant’s Common Equity, Related Shareholder Matters and Issuer Purchases of Equity Securities24Item 6. Selected Financial Data25Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations26Item 7A. Quantitative and Qualitative Disclosures About Market Risk31Item 8. Financial Statements and Supplementary Data32Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure32Item 9A. Controls and Procedures32Item 9B. Other Information32PART III Item 10. Directors, Executive Officers and Corporate Governance33Item 11. Executive Compensation33Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Shareholder Matters33Item 13. Certain Relationships and Related Transactions, and Director Independence33Item 14. Principal Accountant Fees and Services33PART IV Item 15. Exhibits, Financial Statement Schedules34Signatures36FORWARD-LOOKING STATEMENTSThis report contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. Forward-looking statementscan be identified by words such as “intends,” “believes,” “anticipates,” “indicates,” “plans,” “expects,” “suggests,” “may,” “should,” “potential,” “designedto,” “will” and similar references. These statements relate to future events or the Company’s anticipated future results of operations. These statements are onlypredictions and involve known and unknown risks, uncertainties and other factors, which may cause actual results to be materially different from theseforward-looking statements. The Company cautions readers not to place undue reliance on any such forward-looking statements, which speak only as of thedate they were made. Certain of these risks, uncertainties, and other factors are described in greater detail in the Company’s filings with the U.S. Securitiesand Exchange Commission (SEC), all of which are available free of charge on the SEC’s website www.sec.gov. These risks include, but are not limited to,risks relating to: the timing for commencement of preclinical studies and clinical trials, the anticipated timing for completion of such studies and trials, andthe anticipated timing for regulatory actions; the success of future development activities for LJPC-501, LJPC-401, and LJPC-30S; potential indications forwhich LJPC-501, LJPC-401, and LJPC-30S may be developed; and the expected duration over which the Company’s cash balances will fund its operations.Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statementsinclude, among others:•the risk that our clinical trials with our product candidates may not be successful in evaluating their safety and tolerability or providing evidence ofefficacy;•the successful and timely completion of clinical trials;•our plans and timing with respect to seeking regulatory approvals and uncertainties regarding the regulatory process;•the availability of funds and resources to pursue our research and development projects, including clinical trials with our product candidates;•uncertainties associated with obtaining and enforcing patents;•the potential commercialization of any of our drug candidates that receive regulatory approval;•our estimates for future performance;•our estimates regarding our capital requirements and our needs for, and ability to obtain, additional financing; and•those risk factors identified in this Annual Report on Form 10-K under the heading “Risk Factors” and in other filings the Company periodicallymakes with the SEC.Forward-looking statements contained in this Annual Report on Form 10-K speak as of the date hereof, and we do not undertake to update any of theseforward-looking statements to reflect a change in our views or events or circumstances that occur after the date of this Annual Report on Form 10-K. Inaddition, please see the “Risk Factors” section of this Annual Report on Form 10-K. These risk factors may be updated from time to time by our future filingsunder the Exchange Act.PART IIn this report, all references to “we,” “our,” “us,” “La Jolla” and “the Company” refer to La Jolla Pharmaceutical Company, a California corporation.Item 1. Business.OverviewLa Jolla Pharmaceutical Company is a biopharmaceutical company focused on the discovery, development and commercialization of innovativetherapies intended to significantly improve outcomes in patients suffering from life-threatening diseases. We have several product candidates indevelopment. LJPC-501 is our proprietary formulation of angiotensin II for the potential treatment of catecholamine-resistant hypotension. LJPC-401 is ournovel formulation of synthetic human hepcidin for the potential treatment of conditions characterized by iron overload, such as hereditary hemochromatosis,beta thalassemia, sickle cell disease and myelodysplastic syndrome. LJPC-30S is our next-generation gentamicin derivative program that is focused ontherapeutics for the potential treatment of serious bacterial infections as well as rare genetic disorders, such as cystic fibrosis and Duchenne musculardystrophy.LJPC-501LJPC-501 is our proprietary formulation of angiotensin II. Angiotensin II, the major bioactive component of the renin-angiotensin system, serves asone of the body’s central regulators of blood pressure. We are developing LJPC-501 for the treatment of catecholamine-resistant hypotension (CRH), which isan acute, life-threatening condition in which blood pressure drops to dangerously low levels in patients who respond poorly to current treatments.Angiotensin II has been shown to raise blood pressure in a pilot, randomized, placebo-controlled clinical trial in CRH, which was published in thejournal Critical Care. We have conducted preclinical pharmacology studies that have demonstrated that catecholamine resistance may be in part a result ofreduced endogenous production of angiotensin II. In October 2014, we presented positive data from a preclinical study of LJPC-501 for the treatment ofCRH.We initiated a Phase 3 trial of LJPC-501 for the treatment of CRH, called the ATHOS (Angiotensin II for the Treatment of High-Output Shock) 3Phase 3 trial, in March 2015. Prior to commencing the ATHOS 3 Phase 3 trial, we reached agreement with the U.S. Food and Drug Administration (FDA) on aSpecial Protocol Assessment (SPA) for this multicenter, randomized, double-blind, placebo-controlled, Phase 3 trial. In accordance with the SPA, the primaryefficacy endpoint for the ATHOS 3 Phase 3 registration trial is increase in blood pressure at three hours. In the ATHOS 3 Phase 3 trial, patients wererandomized in a 1:1 fashion to receive either: (i) LJPC-501 plus standard-of-care vasopressors; or (ii) placebo plus standard-of-care vasopressors. Randomizedpatients received their assigned treatment via continuous IV infusion for up to seven days. The primary efficacy endpoint in the trial is to compare the changein mean arterial pressure in patients with CRH who received an IV infusion of LJPC-501 plus standard-of-care vasopressors to those that received an IVinfusion of placebo plus standard-of-care vasopressors. Secondary endpoints include comparison of changes in cardiovascular Sequential Organ FailureAssessment (SOFA) scores and the safety and tolerability of LJPC-501 in patients with CRH.The ATHOS 3 Phase 3 trial completed enrollment of 344 patients in the fourth quarter of 2016. We expect to report top-line results from the ATHOS3 Phase 3 trial in the first quarter of 2017. If the results from the study are positive, we expect to file a New Drug Application (NDA) for LJPC-501 with theFDA before the end of 2017.LJPC-401LJPC-401 is our novel formulation of synthetic human hepcidin. Hepcidin, an endogenous peptide hormone, is the body’s naturally occurringregulator of iron absorption and distribution. In healthy individuals, hepcidin prevents excessive iron accumulation in vital organs, such as the liver andheart, where it can cause significant damage and even result in death.We are developing LJPC-401 for the potential treatment of iron overload, which occurs as a result of diseases such as hereditary hemochromatosis(HH), beta thalassemia, sickle cell disease (SCD) and myelodysplastic syndrome (MDS). HH is a disease characterized by a genetic deficiency in hepcidin. HHis the most common genetic disease in Caucasians and causes liver cirrhosis, liver cancer, heart disease and/or failure, diabetes, arthritis and joint pain. Betathalassemia, SCD and MDS are genetic diseases of the blood that can cause life-threatening anemia and usually require frequent and life-long blood1transfusions. These blood transfusions cause excessive iron accumulation in the body, which is toxic to vital organs, such as the liver and heart. In addition,the underlying anemia causes excessive iron accumulation independent of blood transfusions.In September 2016, we reported positive results from a Phase 1 trial of LJPC-401 in patients at risk of iron overload suffering from HH, thalassemiaand SCD. Single, escalating doses of LJPC-401 were associated with a dose-dependent, statistically significant reduction in serum iron. LJPC-401 was welltolerated with no dose-limiting toxicities. Injection-site reactions were the most commonly reported adverse event and were all mild or moderate in severity,self-limiting, and fully resolved.Also in September 2016, we announced that we reached agreement with the European Medicines Agency (EMA) on the design of a pivotal trial ofLJPC-401. The pivotal trial will be a randomized, controlled, multicenter trial in beta thalassemia patients suffering from iron overload, a major unmet needin an orphan patient population. The primary endpoint will be a clinically relevant measurement directly related to iron overload. We plan to initiate thistrial in mid-2017. In 2015, the EMA Committee for Orphan Medicinal Products (COMP) designated LJPC-401 as an orphan medicinal product for thetreatment of beta thalassemia intermedia and major. In 2016, the EMA COMP designated LJPC-401 as an orphan medicinal product for the treatment of SCD.LJPC-30SLJPC-30S is our next-generation gentamicin derivative program. Despite kidney toxicity, gentamicin has become one of the most commonlyprescribed hospital antibiotics due to its broad spectrum of antimicrobial efficacy. Gentamicin consists primarily of a mixture of four distinct but closelyrelated chemical entities that may contribute differentially to the product’s toxicity profile.Our LJPC-30S program is focused on therapeutics derived from purified components of the currently marketed gentamicin product that retain thebiologic activity of gentamicin, yet appear to lack the traditional kidney toxicity associated with its use. This program includes the development of potentialtreatments for serious bacterial infections as well as rare genetic disorders, such as cystic fibrosis and Duchenne muscular dystrophy.Gentamicin’s ability to induce a lack of fidelity in gene transcription, intrinsic to its antimicrobial mechanism of action, can also be leveraged in thecorrection of certain human genetic mutations that are the hallmark of diseases such as cystic fibrosis and Duchenne muscular dystrophy. In spite of favorableshort-term clinical proof-of-efficacy data in cystic fibrosis, development of gentamicin as a chronic treatment for these genetic diseases has been limited byits toxicity profile.Following a pre-investigational new drug (IND) meeting with the FDA, we have received guidance that we may proceed with a proposed Phase 1trial following the submission of an IND application.ManufacturingWe do not currently own or operate manufacturing facilities for the production of clinical or commercial quantities of any of our product candidates.We rely on a small number of third-party manufacturers to produce our compounds and expect to continue to do so to meet the requirements of our productcandidates. We do not have long-term agreements with any of these third parties. In all of our manufacturing agreements, we require that third-party contractmanufacturers produce active pharmaceutical ingredients (API) and finished products in accordance with the FDA's current Good Manufacturing Practices(cGMP) and all other applicable laws and regulations. We maintain confidentiality agreements with potential and existing manufacturers in order to protectour proprietary rights related to our drug candidates.With regard to our lead product candidate, LJPC-501, we utilize third parties to manufacture API, formulate, fill and finish, and perform theanalytical release testing of the drug product. To date, LJPC-501 has been manufactured in small quantities for preclinical studies and clinical trials. If LJPC-501 is approved for commercial sale, we will need to manufacture the product in larger quantities. Commercial scale-up of manufacturing requires additionalprocess development and validation, which is subject to FDA review prior to commercial use. We are currently in the process of completing scale-up andprocess validation work. If approved, the commercial success of LJPC-501 will be dependent upon the ability of our contract manufacturers to producecGMP-compliant API and drug product in commercial quantities and at competitive costs. If LJPC-501 is approved for commercial use, we plan to continueto scale-up manufacturing through third-party manufacturers, with the objectives of realizing important economies of scale and security of supply. Thesescale-up activities will take time to2implement, require additional capital investment, process development, validation, and FDA review. We cannot guarantee that we will be successful inachieving competitive manufacturing costs through such scale-up activities.Patents and Proprietary TechnologiesPatents and other proprietary rights are important to our business. As part of our strategy to protect our current product candidates and to provide afoundation for future products, we have filed a number of patent applications and have licensed rights from third parties for other patent applications relatedto our product candidates.As of December 31, 2016, we owned or had the rights to 31 issued patents (19 U.S. and 12 foreign) and 115 pending applications (29 U.S. and 86foreign). These patents and patent applications owned or licensed by us cover our LJPC-501, LJPC-401, and LJPC-30S programs, as well as other programs(discontinued GCS-100 and LJPC-1010 and new development programs). United States ForeignDescription Issued Pending Expiration Issued Pending ExpirationLJPC-501 3 8 2029 - 2037 — 26 2034 - 2036LJPC-401 1 6 2022 - 2037 11 2 2022LJPC-30S 1 2 2027 - 2037 — 1 N/AOther 14 13 2025 - 2037 1 57 2025 - 2036In addition to those above, we plan to file additional patent applications that, if issued, would provide further protection for our LJPC-501, LJPC-401 and LJPC-30S programs. Although we believe the bases for these patents and patent applications are sound, they are untested, and there is no assurancethat they will not be successfully challenged. There can be no assurance that any patent previously issued will be of commercial value, that any patentapplications will result in issued patents of commercial value, or that our technology will not be held to infringe patents held by others.CompetitionThe biotechnology and pharmaceutical industries are subject to rapid technological change. Competition from domestic and foreign biotechnologycompanies, large pharmaceutical companies and other institutions is intense and expected to increase. A number of companies are pursuing the developmentof pharmaceuticals in our targeted areas.Government RegulationPharmaceutical RegulationIf and when we market any pharmaceutical products in the U.S., they will be subject to extensive government regulation. Likewise, if we seek tomarket and distribute any such products abroad, they would also be subject to extensive foreign government regulation.In the U.S., the FDA regulates pharmaceutical products. FDA regulations govern the testing, research and development activities, manufacturing,quality, storage, advertising, promotion, labeling, sale and distribution of pharmaceutical products. Accordingly, there is a rigorous process for the approvalof new drugs and ongoing oversight of marketed products. We are also subject to foreign regulatory requirements governing clinical trials and drug productsif products are tested or marketed abroad. The approval process outside the U.S. varies from jurisdiction to jurisdiction and the time required may be longer orshorter than that required for FDA approval.See Item 1A. Risk Factors of this Annual Report on Form 10-K for a discussion of the factors that could adversely impact our development ofcommercial products and industry regulation.Regulation in the U.S. The FDA testing and approval process requires substantial time, effort and money. We cannot assure you that any of our product candidates will everobtain approval. The FDA approval process for new drugs includes, without limitation:• preclinical studies;3•submission in the U.S. of an IND for clinical trials conducted in the U.S.;•adequate and well-controlled human clinical trials to establish safety and efficacy of the product;•review of an NDA in the U.S.; and•inspection of the facilities used in the manufacturing of the drug to assess compliance with the FDA’s current cGMP regulations.The FDA monitors the progress of trials conducted in the U.S. under an IND and may, at its discretion, re-evaluate, alter, suspend or terminate testingbased on the data accumulated to that point and the FDA’s benefit-risk assessment with regard to the patients enrolled in the trial. The FDA may alsowithdraw approval for an IND for that drug if deemed warranted. Furthermore, even after regulatory approval is obtained, under certain circumstances, such aslater discovery of previously unknown problems, the FDA can withdraw approval or subject the drug to additional restrictions.Preclinical TestingThe testing and approval process requires substantial time, effort and financial resources, and we cannot be certain that any approvals for our productcandidates will be granted on a timely basis, if at all. Preclinical studies include laboratory evaluation of the product, as well as animal studies to assess thepotential safety and effectiveness of the product. Most of these studies must be performed according to Good Laboratory Practices, a system of managementcontrols for laboratories and research organizations to ensure the consistency and reliability of results.An IND is the request for authorization from the FDA to administer an investigational new drug product to humans. The IND includes informationregarding the preclinical studies, the investigational product’s chemistry and manufacturing, supporting data and literature, and the investigational plan andprotocol(s). Clinical trials may begin 30 days after an IND is received, unless the FDA raises concerns or questions about the conduct of the clinical trials. Ifconcerns or questions are raised, an IND sponsor and the FDA must resolve any outstanding concerns before clinical trials can proceed. An IND must becomeeffective before human clinical trials begin.Clinical TrialsClinical trials involve the administration of the product candidate that is the subject of the trial to volunteers or patients under the supervision of aqualified principal investigator and in accordance with a clinical trial protocol, which sets forth details, such as the study objectives and the safety andeffectiveness criteria to be evaluated. Each clinical trial must be reviewed and approved by an independent institutional review board (IRB) in the U.S. orethics committee in the European Union (EU) at each institution at which the study will be conducted. The IRB or ethics committee will consider, amongother things, ethical factors, safety of human subjects and the possible liability of the institution arising from the conduct of the proposed clinical trial. Inaddition, clinical trials in the U.S. must be performed according to good clinical practices, which are enumerated in FDA regulations and guidancedocuments. Some studies include oversight by an independent group of experts, known as a data safety monitoring board, which provides authorization forwhether a study may move forward based on certain data from the study and may stop the clinical trial if it determines that there is an unacceptable safety riskfor subjects or on other grounds.The FDA may order the temporary, or permanent, discontinuation of a clinical trial at any time, or impose other sanctions, if it believes that theclinical trial is not being conducted in accordance with FDA requirements or presents an unacceptable risk to the clinical trial patients. An IRB may alsorequire the clinical trial at the site to be halted, either temporarily or permanently, for failure to comply with the IRB's requirements, or may impose otherconditions.Clinical trials in the U.S. typically are conducted in sequential phases: Phases 1, 2, 3 and 4. The phases may overlap. The FDA may require that wesuspend clinical trials at any time on various grounds, including if the FDA makes a finding that the subjects participating in the trial are being exposed to anunacceptable health risk. In Phase 1 clinical trials, the investigational product is usually tested on a small number of healthy volunteers to determine safety, any adverseeffects, proper dosage, absorption, metabolism, distribution, excretion and other drug effects. Follow-on Phase 1b clinical trials may also evaluate efficacywith respect to trial participants.In Phase 2 clinical trials, the investigational product is usually tested on a limited number of patients (generally up to several hundred) topreliminarily evaluate the efficacy of the drug for specific, targeted indications, determine dosage tolerance4and optimal dosage, and identify possible adverse effects and safety risks. Multiple Phase 2 clinical trials may be conducted to obtain information prior tobeginning Phase 3 clinical trials.In Phase 3 clinical trials, the investigational product is administered to an expanded patient population to support proof of concept and efficacyclaims, provide evidence of clinical efficacy and to further test for safety, generally at multiple clinical sites.In Phase 4 clinical trials or other post-approval commitments, additional studies and patient follow-up are conducted to gain experience from thetreatment of patients in the intended therapeutic indication. FDA may require a commitment to conduct post-approval Phase 4 studies as a condition ofapproval. Additional studies and follow-up may be conducted to document a clinical benefit where drugs are approved under accelerated approvalregulations and based on surrogate endpoints. In clinical trials, surrogate endpoints are alternative measurements of the symptoms of a disease or conditionthat are substituted for measurements of observable clinical symptoms. Failure to timely conduct Phase 4 clinical trials and follow-up could result inwithdrawal of approval for products approved under accelerated approval regulations.We cannot assure you that any of our current or future clinical trials will result in approval to market our products. Clinical Data Review and Approval in the U.S.The data from the clinical trials, together with preclinical data and other supporting information that establishes a drug candidate’s safety, aresubmitted to the FDA in the form of an NDA, or NDA supplement (for approval of a new indication if the product candidate is already approved for anotherindication). Under applicable laws and FDA regulations, FDA reviews the NDA within 60 days of receipt of the NDA to determine whether the applicationwill be accepted for filing based on FDA’s threshold determination that the NDA is sufficiently complete to permit substantive review. If deemed complete,the FDA will “file” the NDA, thereby triggering substantive review of the application. The FDA can refuse to file any NDA that it deems incomplete or notproperly reviewable. The FDA has established internal substantive review goals of ten months for most NDAs. The FDA has various programs, including Fast Track,priority review, and accelerated approval, which are intended to expedite or simplify the process for reviewing drugs, and/or provide for approval based onsurrogate endpoints. Even if a drug qualifies for one or more of these programs, the FDA may later decide that the drug no longer meets the conditions forqualification or that the period for FDA review or approval will not be shortened. Generally, drugs that may be eligible for these programs are those forserious or life-threatening conditions, those with the potential to address unmet medical needs, and those that offer meaningful benefits over existingtreatments. For example, Fast Track is a process designed to facilitate the development, and expedite the review, of drugs to treat serious diseases and fill anunmet medical need. The request may be made at the time of IND submission and generally no later than the pre-NDA meeting. The FDA will respond within60 calendar days of receipt of the request. Priority review, which is requested at the time of an NDA submission, is designed to give drugs that offer majoradvances in treatment or provide a treatment where no adequate therapy exists, an initial review within six months as compared to a standard review time often months. Although Fast Track and priority review do not affect the standards for approval, the FDA will attempt to facilitate early and frequent meetingswith a sponsor of a Fast Track designated drug and expedite review of the application for a drug designated for priority review. Accelerated approval providesan earlier approval of drugs to treat serious diseases, and that fill an unmet medical need based on a surrogate endpoint. The FDA, however, is not legallyrequired to complete its review within these periods, and these performance goals may change over time.If the FDA approves the NDA, it will issue an approval letter authorizing the commercial marketing of the drug with prescribing information forspecific indications. As a condition of NDA approval, the FDA may require a risk evaluation and mitigation strategy (REMS) to help ensure that the benefitsof the drug outweigh the potential risks. REMS can include medication guides, communication plans for healthcare professionals, and elements to assure safeuse. Additionally, the FDA will inspect the facility or the facilities at which the drug is manufactured. Moreover, product approval may require substantialpost-approval testing and surveillance to monitor the drug's safety or efficacy. Once granted, product approvals may be withdrawn if compliance withregulatory standards is not maintained or problems are identified following initial marketing. In many cases, the outcome of the review, even if generallyfavorable, is not an actual approval, but a “complete response” that generally outlines the deficiencies in the submission, which may require substantialadditional testing, or information, in order for the FDA to reconsider the application. If, or when, those deficiencies have been addressed to the FDA'ssatisfaction in a resubmission of the NDA, the FDA will issue an approval letter. Satisfaction of FDA requirements or similar requirements of state, local, and foreign regulatory agencies typically takes several years and requires theexpenditure of substantial financial resources. Information generated in this process is5susceptible to varying interpretations that could delay, limit or prevent regulatory approval at any stage of the process. Accordingly, the actual time andexpense required to bring a product to market may vary substantially. We cannot assure you that we will submit applications for required authorizations tomanufacture and/or market potential products or that any such application will be reviewed and approved by the appropriate regulatory authorities in atimely manner, if at all. Data obtained from clinical activities is not always conclusive and may be susceptible to varying interpretations, which could delay,limit or prevent regulatory approval. Success in early stage clinical trials does not ensure success in later stage clinical trials. Even if a product candidatereceives regulatory approval, the approval may be significantly limited to specific disease states, patient populations and dosages, or have conditions placedon it that restrict the commercial applications, advertising, promotion or distribution of these products.Once issued, the FDA may withdraw product approval if ongoing regulatory standards are not met or if safety problems occur after the productreaches the market. In addition, the FDA may require testing and surveillance programs to monitor the safety or effectiveness of approved products whichhave been commercialized, and the FDA has the power to prevent or limit further marketing of a product based on the results of these post-marketingprograms. The FDA may also request or require additional Phase 4 clinical trials after a product is approved. The results of Phase 4 clinical trials can confirmthe effectiveness of a product candidate and can provide important safety information to augment the FDA’s voluntary adverse drug reaction reportingsystem. Any products manufactured or distributed by us pursuant to FDA approvals would be subject to continuing regulation by the FDA, including record-keeping requirements and reporting of adverse experiences with the drug. Drug manufacturers and their subcontractors are required to register theirestablishments with the FDA and certain state agencies and are subject to periodic unannounced inspections by the FDA and certain state agencies forcompliance with cGMP, which impose certain procedural and documentation requirements upon us and our third-party manufacturers. We cannot be certainthat we, or our present or future suppliers, will be able to comply with the cGMP regulations and other FDA regulatory requirements. In addition, both before and after approval is sought, we are required to comply with a number of FDA requirements. For example, we are required toreport certain adverse reactions and production problems, if any, to the FDA, and to comply with certain limitations and other requirements concerningadvertising and promotion for our products. In addition, quality control and manufacturing procedures must continue to conform to cGMP after approval, andthe FDA periodically inspects manufacturing facilities to assess compliance with continuing cGMP. In addition, discovery of problems, such as safetyproblems, may result in changes in labeling or restrictions on a product manufacturer or NDA holder, including removal of the product from the market.The FDA closely regulates the marketing and promotion of drugs. Approval may be subject to post-marketing surveillance and other record-keepingand reporting obligations, and involve ongoing requirements. Product approvals may be withdrawn if compliance with regulatory standards is notmaintained or if problems occur following initial marketing. A company can make only those claims relating to safety and efficacy that are approved by theFDA. Failure to comply with these requirements can result in adverse publicity, warning letters, corrective advertising and potential civil and criminalpenalties.Clinical Trial Conduct and Product Approval Regulation in Non-U.S. JurisdictionsIn addition to regulations in the U.S., we may be subject to a variety of foreign regulations governing clinical trials and commercial sales anddistribution of our products. Our clinical trials conducted in the EU must be done under a clinical trial application (CTA), which must be supported by anInvestigational Medicinal Product Dossier (IMPD), and the oversight of an ethics committee. If we market our products in foreign countries, we also will besubject to foreign regulatory requirements governing marketing approval for pharmaceutical products. The requirements governing the conduct of clinicaltrials, product approval, pricing and reimbursement vary widely from country to country. Whether or not FDA approval has been obtained, approval of aproduct by the comparable regulatory authorities of foreign countries must be obtained before manufacturing or marketing the product in those countries.The approval process varies from country to country and the time required for such approvals may differ substantially from that required for FDA approval.There is no assurance that any future FDA approval of any of our product candidates will result in similar foreign approvals or vice versa. The process forclinical trials in the EU is similar, and trials are heavily scrutinized by the designated ethics committee.6Section 505(b)(2) ApplicationsSome of our product candidates may be eligible for submission of applications for approval under the FDA’s Section 505(b)(2) approval process,which provides an alternate path to FDA approval for new or improved formulations or new uses of previously approved products. Section 505(b)(2) wasenacted as part of the Drug Price Competition and Patent Term Restoration Act of 1984, also known as the Hatch-Waxman Act, and allows approval of NDAsthat rely, at least in part, on studies that were not conducted by or for the applicant and to which the applicant has not obtained a right of reference. Suchstudies can be provided by published literature, or the FDA can rely on previous findings of safety and efficacy for a previously approved drug. If the 505(b)(2) applicant can establish that reliance on the FDA's previous approval is scientifically appropriate, it may eliminate the need to conduct certain preclinicalstudies or clinical trials of the new product. Section 505(b)(2) applications may be submitted for drug products that represent a modification (e.g., a newindication or new dosage form) of an eligible approved drug. In such cases, the additional information in 505(b)(2) applications necessary to support thechange from the previously approved drug is frequently provided by new studies submitted by the applicant. Because a Section 505(b)(2) application reliesin part on previous studies or previous FDA findings of safety and effectiveness, preparing 505(b)(2) applications is generally less costly and time-consumingthan preparing an NDA based entirely on new data and information from a full set of clinical trials. The FDA may approve the new product candidate for all,or some, of the label indications for which the referenced product has been approved, as well as for any new indication sought by the Section 505(b)(2)applicant. The law governing Section 505(b)(2) or FDA’s current policies may change in such a way as to adversely affect our applications for approval thatseek to utilize the Section 505(b)(2) approach. Such changes could result in additional costs associated with additional studies or clinical trials and delays.The FDA provides that reviews and/or approvals of applications submitted under Section 505(b)(2) will be delayed in various circumstances. Forexample, the holder of the NDA for the listed drug may be entitled to a period of market exclusivity during which the FDA will not approve, and may noteven review, a Section 505(b)(2) application from other sponsors. If the listed drug is claimed by one or more patents that the NDA holder has listed with theFDA, the Section 505(b)(2) applicant must submit a certification with respect to each such patent. If the 505(b)(2) applicant certifies that a listed patent isinvalid, unenforceable or not infringed by the product that is the subject of the Section 505(b)(2) application, it must notify the patent holder and the NDAholder. If, within 45 days of providing this notice, the NDA holder sues the 505(b)(2) applicant for patent infringement, the FDA will not approve theSection 505(b)(2) application until the earlier of a court decision favorable to the Section 505(b)(2) applicant or the expiration of 30 months. The regulationsgoverning marketing exclusivity and patent protection are complex, and it is often unclear how they will be applied in particular circumstances.Drug Enforcement Agency RegulationOur research and development processes involve the controlled use of hazardous materials, including chemicals. Some of these hazardous materialsare considered to be controlled substances and subject to regulation by the U.S. Drug Enforcement Agency (DEA). Controlled substances are those drugs thatappear on one of five schedules promulgated and administered by the DEA under the Controlled Substances Act (CSA). The CSA governs, among otherthings, the distribution, recordkeeping, handling, security and disposal of controlled substances. We must be registered by the DEA in order to engage inthese activities, and are subject to periodic and ongoing inspections by the DEA and similar state drug enforcement authorities to assess ongoing compliancewith the DEA’s regulations. Any failure to comply with these regulations could lead to a variety of sanctions, including the revocation, or a denial of renewal,of the DEA registration, injunctions or civil or criminal penalties.Third-Party Payor Coverage and ReimbursementAlthough none of our current product candidates have been approved or commercialized for any indication as of the date of this report, if they areapproved for marketing, commercial success of our product candidates will depend, in part, upon the availability of coverage and reimbursement from third-party payors at the federal, state and private levels. Government payor programs, including Medicare and Medicaid, private healthcare insurance companiesand managed care plans have attempted to control costs by limiting coverage and the amount of reimbursement for particular procedures or drug treatments.The U.S. Congress and state legislatures, from time to time, propose and adopt initiatives aimed at cost containment. Ongoing federal and state governmentinitiatives directed at lowering the total cost of healthcare will likely continue to focus on healthcare reform, the cost of prescription pharmaceuticals and onthe reform of the Medicare and Medicaid payment systems.7Examples of how limits on drug coverage and reimbursement in the U.S. may cause reduced payments for drugs in the future include:•changing Medicare reimbursement methodologies;•fluctuating decisions on which drugs to include in formularies;•revising drug rebate calculations under the Medicaid program or requiring that new or additional rebates be provided to Medicare, Medicaid, otherfederal or state healthcare programs; and•reforming drug importation laws.Some third-party payors also require pre-approval of coverage for new drug therapies before they will reimburse healthcare providers that use suchtherapies. While we cannot predict whether any proposed cost-containment measures will be adopted or otherwise implemented in the future, theannouncement or adoption of these proposals could have a material adverse effect on our ability to obtain adequate prices for our product candidates and tooperate profitably.Reimbursement systems in international markets vary significantly by country and, within some countries, by region. Reimbursement approvalsmust be obtained on a country-by-country basis. In many foreign markets, including markets in which we hope to sell our products, the pricing ofprescription pharmaceuticals is subject to government pricing control. In these markets, once marketing approval is received, pricing negotiations could takesignificant additional time. As in the U.S., the lack of satisfactory reimbursement or inadequate government pricing of any of our products would limitwidespread use and lower potential product revenues.Anti-Kickback, Fraud and Abuse and False Claims Regulation Upon commercial launch of a product in the U.S., we will be subject to healthcare fraud and abuse regulation and enforcement by both the federalgovernment and the states in which we conduct our business. Healthcare providers, physicians and third-party payors play a primary role in therecommendation and prescription of any product candidates for which we obtain marketing approval. Arrangements with third-party payors and customersmay expose us to applicable fraud and abuse and other healthcare laws and regulations that may constrain the business or financial arrangements andrelationships through which we market, sell and distribute our products for which we obtain marketing approval.Regulations under applicable federal and state healthcare laws and regulations include the federal healthcare programs’ Anti-Kickback Law, whichprohibits, among other things, persons from knowingly and willfully soliciting, receiving, offering or paying remuneration, directly or indirectly, inexchange for or to induce either the referral or purchase of any good or service for which payment may be made under federal healthcare programs such as theMedicare and Medicaid programs. Remuneration has been broadly defined to include anything of value, including cash, improper discounts, and free orreduced price items and services. Many states have similar laws that apply to their state healthcare programs as well as private payors. In addition, the FalseClaims Act (FCA) imposes liability on persons who, among other things, present or cause to be presented false or fraudulent claims for payment by a federalhealthcare program. The FCA has been used to prosecute persons submitting claims for payment that are inaccurate or fraudulent, that are for services notprovided as claimed, or for services that are not medically necessary. Actions under the FCA may be brought by the Attorney General or as a qui tam actionby a private individual in the name of the government. Violations of the FCA can result in significant monetary penalties and treble damages. The federalgovernment is using the FCA, and the accompanying threat of significant liability, in its investigation and prosecution of pharmaceutical and biotechnologycompanies throughout the country, for example, in connection with the promotion of products for unapproved uses and other sales and marketing practices.The risk of being found in violation of these laws is increased by the fact that many of them have not been fully interpreted by the regulatoryauthorities or the courts, and their provisions are open to a variety of interpretations. Moreover, recent healthcare reform legislation has strengthened many ofthese laws. For example, the Patient Protection and Affordable Care Act (PPACA), among other things, amends the intent requirement of the federal anti-kickback and criminal healthcare fraud statutes to clarify that a person or entity does not need to have actual knowledge of this statute or specific intent toviolate it. In addition, PPACA provides that a claim including items or services resulting from a violation of the federal anti-kickback statute constitutes afalse or fraudulent claim for purposes of the false claims statutes.The continuing interpretation and application of these laws could have a material adverse impact on our business and our ability to compete shouldwe commence marketing a product.8Federal and State Sunshine LawsIn the event we receive approval of a product candidate for marketing, we will need to comply with federal “sunshine” laws that require transparencyregarding financial arrangements with healthcare providers. This would include the reporting and disclosure requirements imposed by the PPACA on drugmanufacturers regarding any “payment or transfer of value” made or distributed to physicians and teaching hospitals. Failure to submit required informationcan result in civil monetary penalties. A number of states have laws that require the implementation of commercial compliance programs, impose restrictionson drug manufacturer marketing practices, and/or require pharmaceutical companies to track and report payments, gifts and other benefits provided tophysicians and other healthcare professionals and entities.Foreign Corrupt Practices ActIn addition, we may in the future be subject to the Foreign Corrupt Practices Act of 1997 (FCPA). The FCPA and other similar anti-bribery laws inother jurisdictions, such as the U.K. Bribery Act, generally prohibit companies and their intermediaries from providing money or anything of value toofficials of foreign governments, foreign political parties, or international organizations with the intent to obtain or retain business or seek a businessadvantage. Recently, there has been a substantial increase in anti-bribery law enforcement activity by U.S. regulators, with more frequent and aggressiveinvestigations and enforcement proceedings by both the Department of Justice and the U.S. Securities and Exchange Commission (SEC). A determinationthat our operations or activities are not, or were not, in compliance with U.S. or foreign laws or regulations could result in the imposition of substantial fines,interruptions of business, loss of supplier, vendor or other third-party relationships, termination of necessary licenses and permits, and other legal or equitablesanctions. Other internal or government investigations or legal or regulatory proceedings, including lawsuits brought by private litigants, may also follow asa consequence.Patient Privacy and Data SecurityWe are required to comply, as applicable, with numerous federal and state laws, including state security breach notification laws, state healthinformation privacy laws and federal and state consumer protection laws, and to govern the collection, use and disclosure of personal information. Othercountries also have, or are developing, laws governing the collection, use and transmission of personal information. In addition, most healthcare providerswho may prescribe products we may sell in the future and from whom we may obtain patient health information are subject to privacy and securityrequirements under the Health Insurance Portability and Accountability Act of 1996 (HIPAA), as amended by the Health Information Technology andClinical Health Act (HITECH), and its implementing regulations. We are not a HIPAA covered entity, do not currently intend to become one, and we do notoperate as a business associate to any covered entities. Therefore, these privacy and security requirements do not apply to us. However, we could be subject tocivil and criminal penalties if we knowingly obtain individually identifiable health information from a covered entity in a manner that is not authorized orpermitted by HIPAA or for aiding and abetting the violation of HIPAA. The legislative and regulatory landscape for privacy and data protection continues toevolve, and there has been an increasing amount of focus on privacy and data protection issues with the potential to affect our business, including recentlyenacted laws in a majority of states requiring security breach notification. These laws could create liability for us or increase our cost of doing business, andany failure to comply could result in harm to our reputation, and potentially fines and penalties.In addition, state laws govern the privacy and security of health information in certain circumstances, many of which differ from each other insignificant ways and may not have the same effect, thus complicating compliance efforts.Environmental, Health and Safety LawsOur operations are subject to complex and increasingly stringent environmental, health and safety laws and regulations. Further, in the future, wemay open manufacturing facilities that would likely be subject to environmental and health and safety authorities in the relevant jurisdictions. Theseauthorities typically administer laws which regulate, among other matters, the emission of pollutants into the air (including the workplace), the discharge ofpollutants into bodies of water, the storage, use, handling and disposal of hazardous substances, the exposure of persons to hazardous substances, and thegeneral health, safety and welfare of employees and members of the public. Violations of these laws could subject us to strict liability, fines, or liability tothird parties.9Other LawsWe are subject to a variety of financial disclosure and securities trading regulations as a public company in the U.S., including laws relating to theoversight activities of the SEC and the regulations of the NASDAQ, on which our shares are traded. We are also subject to various laws, regulations andrecommendations relating to safe working conditions, laboratory practices and the experimental use of animals. EmployeesAs of February 17, 2017, we employed 105 regular full-time employees, 83 of whom are engaged in research and clinical development activities,and 22 of whom are in marketing, finance, information technology, human resources and administration.None of our employees are covered by a collective bargaining agreement.Company InformationLa Jolla was incorporated in Delaware in 1989 and reincorporated in California in 2012.On January 29, 2014, our common stock was approved for listing and began trading on The NASDAQ Capital Market under the symbol LJPC.Our principal offices are located at 10182 Telesis Court, 6th Floor, San Diego, CA 92121. Our telephone number is (858) 207-4264. Our websiteaddress is www.ljpc.com.Available InformationYou are advised to read this Annual Report on Form 10-K in conjunction with other reports and documents that we file from time to time with theSEC. In particular, please read our definitive proxy statements, our Quarterly Reports on Form 10-Q and any Current Reports on Form 8-K that we may filefrom time to time. You may obtain copies of these reports after the date of this Annual Report directly from us or from the SEC at the SEC’s Public ReferenceRoom at 100 F Street, N.E. Washington, D.C. 20549. In addition, the SEC maintains information for electronic filers (including us) at its website atwww.sec.gov. The public may obtain information regarding the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. We makeour periodic and current reports available on our internet website at www.ljpc.com, free of charge, as soon as reasonably practicable after such material iselectronically filed with, or furnished to, the SEC.10Item 1A. Risk Factors.An investment in our common stock involves a high degree of risk. You should carefully consider the risks described below and the otherinformation before deciding to invest in our common stock. The risks described below are not the only ones facing our Company. Additional risks notpresently known to us or that we currently consider immaterial may also adversely affect our business. We have attempted to identify below the major factorsthat could cause differences between actual and planned or expected results, but we cannot assure you that we have identified all of those factors.If any of the following risks actually happen, our business, financial condition and operating results could be materially adversely affected. In thiscase, the trading price of our common stock could decline, and you could lose all or part of your investment.I. RISK FACTORS RELATING TO THE COMPANY AND THE INDUSTRY IN WHICH WE OPERATEWe are substantially dependent upon the approval and commercial success of LJPC-501.The success of our business is largely dependent upon our ability to develop and commercialize LJPC-501, our most advanced product candidate.We have invested a significant portion of our time and financial resources into the development of LJPC-501, which is being developed for the treatment ofcatecholamine-resistant hypotension (CRH). In the first quarter of 2017, we expect to report top-line results from our ATHOS 3 Phase 3 trial, which isevaluating the efficacy and safety of LJPC-501 for the treatment of CRH. If the results of this study are negative or inconclusive, we may be unable to file anNDA seeking approval of LJPC-501 for regulatory approval. Further, even if the ATHOS 3 Phase 3 trial results are positive, there can be no assurance that theFDA or any other regulatory agency will approve LJPC-501 for commercialization. More specifically, the FDA’s review of any potential NDA submissionmay not produce positive decisions as to whether LJPC-501 is safe and effective in its proposed use(s) and whether its benefits outweigh the risks.Our ability to generate revenue in the next several years and our future success, in large part, depends on the success of the ATHOS 3 Phase 3 trial,the approval of LJPC-501, the nature of any potential requirements for post-approval studies and the successful commercialization of LJPC-501, if approved.We will not be able to commercialize LJPC-501 unless the ATHOS 3 Phase 3 trial is successful and, if successful, until we obtain regulatory approval in theUnited States. Delays in obtaining regulatory approval for LJPC-501, or the issuance of a complete response letter by the FDA, would, among otherconsequences, delay the launch of LJPC-501 and may impact our ability to raise additional capital, which would have a material adverse effect on ourbusiness and financial condition.The commercial success of LJPC-501 and any other current or future product candidates will depend upon the degree of market acceptance byphysicians, patients, third-party payors and others in the medical community.Even with the requisite approvals from the FDA and comparable foreign regulatory authorities, the commercial success of LJPC-501 and any otherproduct candidates will depend in part on physicians, patients, third-party payors and others in the medical community accepting our product candidates asmedically useful, cost-effective and safe. Any product that we bring to the market may not gain market acceptance by physicians, patients, third-party payorsand others in the medical community. The degree of market acceptance of any of our product candidates, if approved for commercial sale, will depend on anumber of factors, including:•the efficacy of the product as demonstrated in clinical trials and potential advantages over competing treatments;•the prevalence and severity of any side effects, including any limitations or warnings contained in a product’s approved labeling;•the clinical indications for which approval is granted;•the relative convenience and ease of administration;•the cost of treatment, particularly in relation to competing treatments;•the willingness of the target patient population to try new therapies and of physicians to prescribe these therapies;•the strength of marketing and distribution support and timing of market introduction of competitive products;•the publicity concerning our products or competing products and treatments; and•sufficient third-party insurance coverage and reimbursement.11Even if a potential product such as LJPC-501 displays a favorable efficacy and safety profile in nonclinical and clinical trials, market acceptance ofthe product will not be fully known until after it is launched. Our efforts to educate the medical community and third-party payors on the benefits of theproduct candidates may require significant resources and may never be successful. If LJPC-501 or other product candidates are approved but fail to achievean adequate level of acceptance by physicians, patients, third-party payors and others in the medical community, we will not be able to generate sufficientrevenue to become or remain profitable.We have only limited assets and will need to raise additional capital before we can expect to become profitable.As of December 31, 2016, we had minimal revenue sources, an accumulated deficit of $606.7 million and available cash and cash equivalents of$65.7 million. To fund future operations to the point where we are able to generate positive cash flow from the sales or out-licensing of our drug candidates,we will need to raise significant additional capital. The amount and timing of future funding requirements will depend on many factors, including the timingand results of our ongoing development efforts, the potential expansion of our current development programs, potential new development programs andrelated general and administrative support. We anticipate that we will seek to fund our operations through public and private equity and debt financings orother sources, such as potential licenses or other collaboration agreements. We cannot assure you that anticipated additional financing will be available to uson favorable terms, or at all. Although we have previously been successful in obtaining financing through equity securities offerings, there can be noassurance that we will be able to do so in the future. If we are unable to raise additional capital to fund our clinical development, commercialization of LJPC-501, if approved, and other business activities, we could be forced to abandon one or more programs and curtail or cease our operations.We have never generated any revenue from product sales and may never be profitable.We have no products approved for commercialization and have never generated any revenue from product sales. Our ability to generate revenue andachieve profitability depends on our ability, alone or with strategic collaboration partners, to successfully complete the development of, and obtain theregulatory and marketing approvals necessary to commercialize LJPC-501 or our other product candidates in development. Our ability to generate futurerevenue from product sales depends heavily on our success in many areas, including but not limited to:•successfully completing research and nonclinical and clinical development of our product candidates;•obtaining regulatory and marketing approvals for product candidates for which we complete clinical trials;•launching and commercializing product candidates for which we obtain regulatory and marketing approval, either directly or with a collaborator ordistributor;•obtaining market acceptance of our product candidates as viable treatment options;•addressing any competing technological and market developments;•identifying, assessing, acquiring or developing new product candidates;•negotiating favorable terms in any collaboration, licensing or other arrangements into which we may enter;•maintaining, protecting and expanding our portfolio of intellectual property rights, including patents, trade secrets and know-how; and•attracting, hiring and retaining qualified personnel.Even if LJPC-501 or one of our other product candidates that we develop is approved for commercial sale, we anticipate incurring significant costsassociated with commercializing any approved product candidate. Our expenses could increase beyond expectations if we are required by the FDA, the EMAor other regulatory agencies, domestic or foreign, to change our manufacturing processes or assays, or to perform clinical, nonclinical or other types of studiesin addition to those that we currently anticipate. In cases where we are successful in obtaining regulatory approvals to market LJPC-501 or one of our otherproduct candidates, our revenue will be dependent, in part, upon the size of the markets in the territories for which we gain regulatory approval, the acceptedprice for the product, the ability to get reimbursement at any price, and whether we own the commercial rights for that territory. If the number of ouraddressable patients is not as significant as we estimate, the indication approved by regulatory authorities is narrower than we expect, or the reasonablyaccepted population for treatment is narrowed by competition, physician choice or treatment guidelines, we may not generate significant revenue from salesof such products, even if approved. Additionally, if we are not able to generate revenue from the sale of any approved products, we may never becomeprofitable.12We currently have no marketing and sales force. If we are unable to establish effective marketing and sales capabilities or enter into agreements withthird parties to market and sell LJPC-501 or other product candidates that may be approved, we may not be able to effectively generate productrevenues.If the ATHOS 3 Phase 3 study is successful and LJPC-501 is approved for commercialization, we currently intend to seek to commercialize thisproduct in the United States directly. However, we currently do not have a marketing or sales team for the marketing, sales and distribution of any productcandidates. In order to commercialize LJPC-501, if approved or any other product candidates that may be approved, we must build, on a territory-by-territorybasis, marketing, sales, distribution, managerial and other non-technical capabilities or make arrangements with third parties to perform these services, and wemay not be successful in doing so. If LJPC-501 receives regulatory approval, we intend to establish an internal sales and marketing team with technicalexpertise and supporting distribution capabilities to commercialize this product, which will be expensive and time-consuming and will require significantattention of our leadership team to manage. Any failure or delay in the development of our internal sales, marketing and distribution capabilities wouldadversely impact the commercialization of LJPC-501 and any other products for which we may obtain marketing approval. Additionally, we may choose tocollaborate, either globally or on a territory-by-territory basis, with third parties that have direct sales forces and established distribution systems, either toaugment or in lieu of our own sales force and distribution systems. If, when needed, we are unable to enter into such arrangements on acceptable terms or atall, we may not be able to successfully commercialize any of our product candidates that receive regulatory approval or any such commercialization mayexperience delays or limitations. If we are not successful in commercializing LJPC-501 or other product candidates, either on our own or throughcollaborations with one or more third parties, our future product revenue will suffer and we may incur significant additional losses.The technology underlying our compounds is uncertain and unproven.The development efforts for LJPC-501, LJPC-401, and LJPC-30S are based on unproven technologies and therapeutic approaches that have not beenwidely tested or used. To date, no products that use the technology underlying these drug candidates have been approved or commercialized. Application ofour technology to treat life-threatening diseases is in early stages. Preclinical studies and future clinical trials of these product candidates may be viewed as atest of our entire approach to developing therapies for patients suffering from life-threatening diseases. If our product candidates do not work as intended, orif the data from our future clinical trials indicate that our product candidates are not safe and effective, the applicability of our technology for successfullytreating life-threatening diseases will be highly uncertain. As a result, there is a significant risk that our therapeutic approaches will not prove to besuccessful, and there can be no guarantee that our drug technologies will result in any commercially successful products.Results from any future clinical trials we may undertake may not be sufficient to obtain regulatory approvals to market our drug candidates in the U.S.or other countries on a timely basis, if at all.Drug candidates are subject to extensive government regulations related to development, clinical trials, manufacturing and commercialization. Inorder to sell any product that is under development, we must first receive regulatory approval. To obtain regulatory approval, we must conduct clinical trialsand toxicology studies that demonstrate that our drug candidates are safe and effective. The process of obtaining FDA and foreign regulatory approvals iscostly, time-consuming, uncertain and subject to unanticipated delays.The FDA and foreign regulatory authorities have substantial discretion in the approval process and may not agree that we have demonstrated thatour drug candidates are safe and effective. If our drug candidates are ultimately not found to be safe and effective, we would be unable to obtain regulatoryapproval to manufacture, market and sell them. We can provide no assurances that the FDA or foreign regulatory authorities will approve our drug candidatesor, if approved, what the scope of the approved indication might be.Clinical drug development involves a lengthy and expensive process with an uncertain outcome, and results of earlier studies may not be predictive offuture study results.Clinical testing is expensive and can take many years to complete, and its outcome is inherently uncertain. Failure can occur at any time during theclinical trial process. The results of nonclinical studies and early clinical trials of our product candidates may not be predictive of the results of later-stageclinical trials. Product candidates that have shown promising results in early-stage clinical trials may still suffer significant setbacks in subsequent clinicaltrials. For example, the safety or efficacy results generated to date in our clinical trials do not ensure that later clinical trials will demonstrate similar results.There is a high failure rate for drugs proceeding through clinical trials, and product candidates in later stages of clinical trials may fail to show the desiredsafety and efficacy, despite having progressed through nonclinical studies and initial clinical trials.13A number of companies in the biopharmaceutical industry have suffered significant setbacks in advanced clinical trials due to lack of efficacy or adversesafety profiles, notwithstanding promising results in earlier studies. Moreover, nonclinical and clinical data are often susceptible to varying interpretationsand analyses. We do not know whether any clinical trials we may conduct will demonstrate consistent or adequate efficacy and safety sufficient to obtainregulatory approval to market our drug candidates.Future clinical trials that we may undertake may be delayed or halted.Any clinical trials of our drug candidates that we may conduct in the future may be delayed or halted for various reasons, including:•we do not have sufficient financial resources;•supplies of drug product are not sufficient to treat the patients in the studies;•patients do not enroll in the studies at the rate we expect;•the product candidates are not effective;•patients experience negative side effects or other safety concerns are raised during treatment;•the trials are not conducted in accordance with applicable clinical practices;•there is political unrest at foreign clinical sites; or•there are natural disasters at any of our clinical sites.If any future trials are delayed or halted, we may incur significant additional expenses, and our potential approval of our drug candidates may bedelayed, which could have a severe negative effect on our business.We rely on third parties to conduct our preclinical and clinical trials. If these third parties do not successfully carry out their contractual duties or meetexpected deadlines, we may not be able to obtain regulatory approval for or commercialize our product candidates and our business could besubstantially harmed.We have agreements with third-party contract research organizations (CROs) to monitor and manage data for our preclinical and clinical programs.We rely heavily on these parties for execution of our preclinical and clinical trials, and control only certain aspects of their activities. Nevertheless, we areresponsible for ensuring that each of our studies is conducted in accordance with the applicable protocol, legal, regulatory and scientific standards, and ourreliance on CROs does not relieve us of our regulatory responsibilities. We and our CROs are required to comply with current good clinical practices(cGCPs), which are regulations and guidelines enforced by the FDA and comparable foreign regulatory authorities for products in clinical development.Regulatory authorities enforce these cGCPs through periodic inspections of trial sponsors, principal investigators and trial sites. If we or any of these CROsfails to comply with applicable cGCP regulations, the clinical data generated in our clinical trials may be deemed unreliable and the FDA or comparableforeign regulatory authorities may require us to perform additional clinical trials before approving our marketing applications. We cannot assure you that,upon inspection, such regulatory authorities will determine that any of our clinical trials comply with the cGCP regulations. In addition, our clinical trialsmust be conducted with product produced under cGMP regulations, and will require a large number of test subjects. Our or our CROs’ failure to comply withthese regulations may require us to repeat clinical trials, which would delay the regulatory approval process.If any of our relationships with these third-party CROs terminate, we may not be able to enter into arrangements with alternative CROs or to do so oncommercially reasonable terms. In addition, our CROs are not our employees, and except for remedies available to us under our agreements with such CROs,we cannot control whether or not they devote sufficient time and resources to our ongoing preclinical and clinical programs. If CROs do not successfullycarry out their contractual duties or obligations or meet expected deadlines, if they need to be replaced or if the quality or accuracy of the clinical data theyobtain is compromised due to the failure to adhere to our clinical protocols, regulatory requirements or for other reasons, our clinical trials may be extended,delayed or terminated and we may not be able to obtain regulatory approval for or successfully commercialize our product candidates. As a result, we mayincur significant additional expenses, and our potential approval of our drug candidates may be delayed, which could have a severe negative effect on ourbusiness.14If the third-party manufacturers upon which we rely fail to produce our drug candidates that we require on a timely basis, or to comply with stringentregulations applicable to pharmaceutical drug manufacturers, we may face delays in the trials, regulatory submissions, required approvals orcommercialization of our drug candidates.We do not manufacture our drug candidates nor do we plan to develop any capacity to do so. We contract with third-party manufacturers tomanufacture all of our drug candidates, and we would expect to rely on these third-party manufacturers to produce commercial quantities of LJPC-501, if it isapproved for marketing. The manufacture of pharmaceutical products requires significant expertise and capital investment, including the development ofadvanced manufacturing techniques and process controls. Manufacturers of pharmaceutical products often encounter difficulties in production, whichinclude difficulties with production costs and yields, quality control and assurance and shortages of qualified personnel, as well as compliance with strictlyenforced federal, state and foreign regulations. The third-party manufacturers we contract with may not perform as agreed or may terminate their agreementswith us.In addition to product approval, any facilities in which our drug candidates are manufactured or tested for their ability to meet requiredspecifications must be inspected by and approved by the FDA and/or the EMA before a commercial product can be manufactured. Failure of such a facility tobe approved could delay the approval of one or more of our drug candidates.Any of these factors could cause us to delay or suspend any future clinical trials, regulatory submissions, required approvals or commercialization ofone or more of our drug candidates, entail higher costs and result in our being unable to effectively commercialize products.Our success in developing and marketing our drug candidates depends significantly on our ability to obtain patent protection and operate withoutinfringing on the rights of others.We depend on patents and other intellectual property to prevent others from improperly benefiting from products or technologies that we developedor acquired. Our patents and patent applications cover various technologies and drug candidates. The patent position of biotechnology firms like ours ishighly uncertain and involves complex legal and factual questions, and no consistent policy has emerged regarding the breadth of claims covered inbiotechnology patents or the protection afforded by these patents. Additionally, recent U.S. Supreme Court and Federal Circuit opinions further limit thescope of patentable inventions in the life sciences space and have added increased uncertainty around the validity of certain issued patents and the successfulprosecution of certain pending patent applications. We intend to continue to file patent applications as we believe is appropriate to obtain patents coveringboth our products and processes. There can be no assurance, however, that any additional patents will be issued, that the scope of any patent that has issuedor may issue will be sufficient to protect our technology, or that any current or future issued patent will be held not invalid if subsequently challenged. Thereis a substantial backlog of biotechnology patent applications at the United States Patent and Trademark Office (USPTO), which may delay the review andissuance of any patents.Others, including our competitors, could have patents or patent applications pending that relate to compounds or processes that overlap or competewith our intellectual property or which may affect our freedom to operate.There can be no assurance that third-party patents will not ultimately be found to impact the advancement of our drug candidates. For example, weare aware that the USPTO has issued a patent to a third party with claims that may cover one of our product candidates. While we intend to challenge theissuance and validity of this patent, we may not be successful. If the USPTO or any foreign counterpart issues or has issued any other patents containingcompetitive or conflicting claims, and if these claims are valid, the protection provided by our existing patents or any future patents that may be issued couldbe significantly reduced, and our ability to prevent competitors from developing products or technologies identical or similar to ours could be negativelyaffected. In addition, there can be no guarantee that we would be able to obtain licenses to these patents on commercially reasonable terms, if at all, or that wewould be able to develop or obtain alternative technology. Our failure to obtain a license to a technology or process that may be required to develop orcommercialize one or more of our drug candidates may have a material adverse effect on our business.We do not have complete patent protection for our product candidates, as the active pharmaceutical ingredients in our product candidates are knowncompounds that are not themselves covered by composition of matter patents, and thus may only be protected by formulation or method-of-use patents (tothe extent that such patents are granted and are enforceable) and/or regulatory exclusivity (to the extent available). Therefore, it is possible that a competitorcould develop the same or similar technology if we fail to obtain protection of this type. We may have to incur significant expense and management time indefending or enforcing our patents. If we cannot obtain and maintain effective patent rights and/or regulatory exclusivity for our product candidates, we maynot be able to compete effectively and our business and results of operations would be harmed.15Patent policy and rule changes could increase the uncertainties and costs surrounding the prosecution of our patent applications and the enforcement ordefense of our issued patents.Changes in either the patent laws or interpretation of the patent laws in the U.S. and other countries may diminish the value of our patents or narrowthe scope of our patent protection. The laws of foreign countries may not protect our rights to the same extent as the laws of the U.S. Publications ofdiscoveries in the scientific literature often lag behind the actual discoveries, and patent applications in the U.S. and other jurisdictions are typically notpublished until 18 months after filing, or in some cases not at all. We therefore cannot be certain that we or our licensors were the first to make the inventionsclaimed in our owned and licensed patents or pending applications, or that we or our licensor were the first to file for patent protection of such inventions.Assuming the other requirements for patentability are met, in the U.S. prior to March 15, 2013, the first to make the claimed invention is entitled tothe patent, while outside the U.S., the first to file a patent application is entitled to the patent. After March 15, 2013, under the Leahy-Smith America InventsAct (Leahy-Smith Act), enacted on September 16, 2011, the U.S. has moved to a first-to-file system. The Leahy-Smith Act also includes a number ofsignificant changes that affect the way patent applications will be prosecuted and may also affect patent litigation. The effects of these changes are currentlyunclear as the USPTO must still implement various regulations, the courts have yet to address any of these provisions and the applicability of the act and newregulations on specific patents discussed herein have not been determined and would need to be reviewed. In general, the Leahy-Smith Act and itsimplementation could increase the uncertainties and costs surrounding the prosecution of our patent applications and the enforcement or defense of ourissued patents, all of which could have a material adverse effect on our business and financial condition.If our product candidates infringe the rights of others, we could be subject to expensive litigation or be required to obtain licenses from others todevelop or market them.Our competitors or others may have patent rights that they choose to assert against us or our licensees, suppliers, customers or potentialcollaborators. Moreover, we may not know about patents or patent applications that our products would infringe. For example, because patent applicationsdo not publish for at least 18 months, if at all, and can take many years to issue, there may be currently pending applications unknown to us that may laterresult in issued patents that our product candidates would infringe. In addition, if third parties file patent applications or obtain patents claiming technologyalso claimed by us or our licensors in issued patents or pending applications, we may have to participate in interference proceedings in the USPTO todetermine priority of invention. If third parties file oppositions in foreign countries, we may also have to participate in opposition proceedings in foreigntribunals to defend the patentability of our foreign patent applications.If a third party claims that we infringe its proprietary rights, any of the following may occur:•we may become involved in time-consuming and expensive litigation, even if the claim is without merit;•we may become liable for substantial damages for past infringement if a court decides that our technology infringes a competitor’s patent;•a court may prohibit us from selling or licensing our product without a license from the patent holder, which may not be available oncommercially acceptable terms, if at all, or which may require us to pay substantial royalties or grant cross licenses to our patents; and•we may have to redesign our product candidates or technology so that they do not infringe patent rights of others, which may not bepossible or commercially feasible.If any of these events occur, our business and prospects will suffer and the market price of our common stock will likely decline substantially.The patent protection and patent prosecution for some of our product candidates is dependent on third parties.While we normally seek and gain the right to fully prosecute the patents relating to our product candidates, there may be times when patents relatingto our product candidates are controlled by our licensors. If any of our future licensing partners fail to appropriately prosecute and maintain patent protectionfor patents covering any of our product candidates, our ability to develop and commercialize those product candidates may be materially adversely affectedand we may not be able to prevent competitors from making, using, selling and importing competing products. In addition, even where we now have the rightto control patent prosecution of patents and patent applications we have licensed from third parties, we may still be adversely affected or prejudiced byactions or inactions of our licensors and their counsel that took place prior to us assuming control over patent prosecution.16In addition to patent protection, we will need to successfully preserve our trade secrets. If we are unable to maintain effective proprietary rights for ourproduct candidates or any future product candidates, we may not be able to compete effectively in our markets.In addition to the protection afforded by patents, we rely on trade secret protection and confidentiality agreements to protect proprietary know-howthat is not patentable or that we elect not to patent, processes for which patents are difficult to enforce and any other elements of our product candidatediscovery and development processes that involve information or technology that is not covered by patents. However, trade secrets can be difficult to protect.We seek to protect our proprietary technology and processes, in part, by entering into confidentiality agreements with our employees, consultants, scientificadvisors, and contractors. We also seek to preserve the integrity and confidentiality of our data and trade secrets by maintaining physical security of ourpremises and physical and electronic security of our information technology systems. While we have confidence in these individuals, organizations andsystems, agreements or security measures may be breached, and we may not have adequate remedies for any breach. In addition, our trade secrets mayotherwise become known or be independently discovered by competitors.Although we expect all of our employees and consultants to assign their inventions to us, and all of our employees, consultants, advisors, and anythird parties who have access to our proprietary know-how, information, or technology to enter into confidentiality agreements, we cannot provide anyassurances that all such agreements have been duly executed, that our trade secrets and other confidential proprietary information will not be disclosed orthat competitors will not otherwise gain access to our trade secrets or independently develop substantially equivalent information and techniques.Misappropriation or unauthorized disclosure of our trade secrets could impair our competitive position and may have a material adverse effect on ourbusiness. Additionally, if the steps taken to maintain our trade secrets are deemed inadequate, we may have insufficient recourse against third parties formisappropriating our trade secrets.If we fail to obtain orphan or other regulatory exclusivity for our product candidates, we may face greater commercial competition and our revenuewill be reduced.Regulatory authorities in some jurisdictions, including the U.S. and EU may designate drugs for relatively small patient populations as orphandrugs. Our business strategy for certain of our drug candidates includes seeking orphan drug designation. Under the Orphan Drug Act, the FDA may designatea product as an orphan drug if it is intended to treat a rare disease or condition, defined as a patient population of fewer than 200,000 in the U.S., or a patientpopulation greater than 200,000 in the U.S. where there is no reasonable expectation that the cost of developing the drug will be recovered from sales in theU.S. In the EU, the EMA’s Committee for Orphan Medicinal Products grants orphan drug designation to promote the development of products that areintended for the diagnosis, prevention, or treatment of a life-threatening or chronically debilitating condition affecting not more than five in 10,000 personsin the EU. If orphan drug status is granted, we may be eligible for a period of commercial exclusivity, which would afford us additional protection fromgeneric competition, beyond that protection that may be afforded by patents. Even if a particular disease has a small patient population that we believe maybe eligible for orphan status, it is possible that the FDA and/or EMA may not grant orphan status. If we do not obtain orphan drug exclusivity for our drugproducts and biologic products, particularly for any products that do not have broad patent protection, our competitors may then sell the same drug to treatthe same condition sooner than if we had obtained orphan drug exclusivity and our revenue could be reduced.Because a number of companies compete with us, many of which have greater resources than we do, and because we face rapid changes in technology inour industry, we cannot be certain that our products will be accepted in the marketplace or capture market share.Competition from domestic and foreign biotechnology companies, large pharmaceutical companies and other institutions is intense and is expectedto increase. A number of companies and institutions are pursuing the development of pharmaceuticals in our targeted areas. Many of these companies arevery large, and have financial, technical, sales and distribution and other resources substantially greater than ours. The greater resources of these competitorscould enable them to develop or market competing products more quickly or effectively, making it extremely difficult for us to develop a share of the marketfor our products. These competitors also include companies that are conducting clinical trials and preclinical studies in the field of cancer therapeutics. Ourcompetitors may develop or obtain regulatory approval for products more rapidly than we do. Also, the biotechnology and pharmaceutical industries aresubject to rapid changes in technology. Our competitors may develop and market technologies and products that are more effective or less costly than thosewe are developing or that would render our technology and proposed products obsolete or noncompetitive.17Our product candidates may cause undesirable side effects or have other properties that could delay or prevent their regulatory approval, limit thecommercial profile of an approved label, or result in significant negative consequences following marketing approval, if any.Undesirable side effects caused by our product candidates could cause us or regulatory authorities to interrupt, delay, or halt clinical trials and couldresult in a more restrictive label or the delay or denial of regulatory approval by the FDA or other comparable foreign authorities. Results of our studies couldreveal a high and unacceptable severity and prevalence of undesirable side effects. In such an event, our studies could be suspended or terminated, and theFDA or comparable foreign regulatory authorities could order us to cease further development of or deny or withdraw approval of our product candidates forany or all targeted indications.The drug-related side effects could affect patient recruitment, the ability of enrolled patients to complete the study, or result in potential productliability claims. We carry product liability insurance in the amount of $10.0 million in the aggregate. We believe our product liability insurance coverage issufficient in light of our clinical programs; however, we may not be able to maintain insurance coverage at a reasonable cost or in sufficient amounts toprotect us against losses due to liability. A successful product liability claim or series of claims brought against us could cause our stock price to decline and,if judgments exceed our insurance coverage, could adversely affect our results of operations and business. In addition, regardless of merit or eventualoutcome, product liability claims may result in impairment of our business reputation, withdrawal of clinical trial participants, costs due to related litigation,distraction of management’s attention from our primary business, initiation of investigations by regulators, substantial monetary awards to patients or otherclaimants, the inability to commercialize our product candidates and decreased demand for our product candidates, if approved for commercial sale.Additionally, if one or more of our product candidates receives marketing approval, and we or others later identify undesirable side effects caused bysuch products, a number of potentially significant negative consequences could result, including but not limited to:•regulatory authorities may withdraw approvals of such product;•regulatory authorities may require additional warnings on the label;•we may be required to create a Risk Evaluation and Mitigation Strategy (REMS) plan, which could include a medication guide outlining the risks ofsuch side effects for distribution to patients, a communication plan for healthcare providers, and/or other elements to assure safe use;•we could be sued and held liable for harm caused to patients; and•our reputation may suffer.Any of these events could prevent us from achieving or maintaining market acceptance of the particular product candidate and could significantlyharm our business, results of operations, and prospects.Even if we obtain regulatory approval for a product candidate, our products will remain subject to regulatory scrutiny.If LJPC-501 or other product candidates are approved, they will be subject to ongoing regulatory requirements for manufacturing, labeling,packaging, storage, advertising, promotion, sampling, record-keeping, conduct of post-marketing studies and submission of safety, efficacy and other post-market information, including both federal and state requirements in the U.S. and requirements of comparable foreign regulatory authorities.Manufacturers and manufacturers’ facilities are required to comply with extensive FDA, and comparable foreign regulatory authority, requirements,including ensuring that quality control and manufacturing procedures conform to cGMP regulations. As such, we and our contract manufacturers will besubject to continual review and inspections to assess compliance with cGMP and adherence to commitments made in any NDA, biologic license application(BLA), or market authorization application (MAA). Accordingly, we and others with whom we work must continue to expend time, money, and effort in allareas of regulatory compliance, including manufacturing, production and quality control.Any regulatory approvals that we receive for our product candidates may be subject to limitations on the approved indicated uses for which theproduct may be marketed or to the conditions of approval, or contain requirements for potentially costly post-marketing testing, including Phase 4 clinicaltrials, and surveillance to monitor the safety and efficacy of the product candidate. We will be required to report certain adverse reactions and productionproblems, if any, to the FDA and comparable foreign regulatory authorities. Any new legislation addressing drug safety issues could result in delays inproduct development or commercialization, or increased costs to assure compliance. We will have to comply with requirements18concerning advertising and promotion for our products. Promotional communications with respect to prescription drugs are subject to a variety of legal andregulatory restrictions and must be consistent with the information in the product’s approved label. As such, we may not promote our products for indicationsor uses for which they do not have approval. The holder of an approved NDA, BLA, or MAA must submit new or supplemental applications and obtainapproval for certain changes to the approved product, product labeling or manufacturing process. We could also be asked to conduct post-marketing clinicaltrials to verify the safety and efficacy of our products in general or in specific patient subsets. If original marketing approval were obtained via the acceleratedapproval pathway, we could be required to conduct a successful post-marketing clinical trial to confirm clinical benefit for our products. An unsuccessfulpost-marketing study or failure to complete such a study could result in the withdrawal of marketing approval.If a regulatory agency discovers previously unknown problems with a product, such as adverse events of unanticipated severity or frequency, orproblems with the facility where the product is manufactured, or disagrees with the promotion, marketing or labeling of a product, such regulatory agencymay impose restrictions on that product or us, including requiring withdrawal of the product from the market. If we fail to comply with applicable regulatoryrequirements, a regulatory agency or enforcement authority may, among other things:•issue warning letters;•impose civil or criminal penalties;•suspend or withdraw regulatory approval;•suspend any of our ongoing clinical trials;•refuse to approve pending applications or supplements to approved applications submitted by us;•impose restrictions on our operations, including closing our contract manufacturers’ facilities; or•seize or detain products, or require a product recall.Any government investigation of alleged violations of law could require us to expend significant time and resources in response, and could generatenegative publicity. Any failure to comply with ongoing regulatory requirements may significantly and adversely affect our ability to commercialize andgenerate revenue from our products. If regulatory sanctions are applied or if regulatory approval is withdrawn, the value of our Company and our operatingresults will be adversely affected.We may not be successful in our efforts to identify, license, discover, develop, or commercialize additional product candidates.Although a substantial amount of our effort will focus on the continued clinical testing, potential approval, and commercialization of our existingproduct candidates, the success of our business also depends upon our ability to identify, license, discover, develop or commercialize additional productcandidates. Research programs to identify new product candidates require substantial technical, financial and human resources. We may focus our efforts andresources on potential programs or product candidates that ultimately prove to be unsuccessful. Our research programs or licensing efforts may fail to yieldadditional product candidates for clinical development and commercialization for a number of reasons, including but not limited to the following:•our research or business development methodology or search criteria and process may be unsuccessful in identifying potential product candidates;•we may not be able or willing to assemble sufficient resources to acquire or discover additional product candidates;•our product candidates may not succeed in preclinical or clinical testing;•our potential product candidates may be shown to have harmful side effects or may have other characteristics that may make the productsunmarketable or unlikely to receive marketing approval;•competitors may develop alternatives that render our product candidates obsolete or less attractive;•product candidates we develop may be covered by third parties’ patents or other exclusive rights;•the market for a product candidate may change during our program so that such a product may become unreasonable to continue to develop;•a product candidate may not be capable of being produced in commercial quantities at an acceptable cost, or at all; and19•a product candidate may not be accepted as safe and effective by patients, the medical community or third-party payors.If any of these events occur, we may be forced to abandon our development efforts for a program or programs, or we may not be able to identify,license, discover, develop or commercialize additional product candidates, which would have a material adverse effect on our business and could potentiallycause us to cease operations.If the market opportunities for our product candidates are smaller than we believe, our revenue may be adversely affected, and our business may suffer.Our estimates of the potential market opportunity for each of our product candidates include several key assumptions based on our industryknowledge, industry publications, third-party research reports and other surveys. For example, if LJPC-501 is approved, we expect it will be indicated for useonly in hypotension patients who have failed to respond to conventional catecholamine therapies. However, determining the approximate number ofhypotension patients in a given market who will be catecholamine-resistant requires numerous estimates and assumptions. While we believe that our internalassumptions are reasonable, no independent source has verified such assumptions. If any of these assumptions proves to be inaccurate, then the actual marketfor our product candidates could be smaller than our estimates of our potential market opportunity. If the actual market for our product candidates is smallerthan we estimate, our product revenue may be limited and it may be more difficult for us to achieve or maintain profitability.We may be subject, directly or indirectly, to federal and state healthcare fraud and abuse laws, false claims laws and health information privacy andsecurity laws. If we are unable to comply, or have not fully complied, with such laws, we could face substantial penalties.If we obtain FDA approval for LJPC-501 or any of our other product candidates and begin commercializing those products in the U.S., ouroperations may be directly, or indirectly through our customers, subject to various federal and state fraud and abuse laws, including, without limitation, thefederal Anti-Kickback Statute, the federal FCA and physician sunshine laws and regulations. These laws may impact, among other things, our proposed sales,marketing and education programs. In addition, we may be subject to patient privacy regulation by both the federal government and the states in which weconduct our business. The laws that may affect our ability to operate include:•the federal Anti-Kickback Statute, which prohibits, among other things, persons from knowingly and willfully soliciting, receiving, offering orpaying remuneration, directly or indirectly, to induce, or in return for, the purchase or recommendation of an item or service reimbursable under afederal healthcare program, such as the Medicare and Medicaid programs;•federal civil and criminal false claims laws and civil monetary penalty laws, which prohibit, among other things, individuals or entities fromknowingly presenting, or causing to be presented, claims for payment from Medicare, Medicaid or other third-party payors that are false orfraudulent;•HIPAA, which created new federal criminal statutes that prohibit executing a scheme to defraud any healthcare benefit program and making falsestatements relating to healthcare matters;•HIPAA, as amended by the federal Health Information Technology for Economic and Clinical Health Act and its implementing regulations, whichimposes certain requirements relating to the privacy, security and transmission of individually identifiable health information;•the federal physician sunshine requirements under the Patient Protection and Affordable Care Act and the Health Care and Education ReconciliationAct of 2010 (Health Care Reform Laws) require manufacturers of drugs, devices, biologics, and medical supplies to report annually to the U.S.Department of Health and Human Services information related to payments and other transfers of value to physicians, other healthcare providers, andteaching hospitals, and ownership and investment interests held by physicians and other healthcare providers and their immediate family membersand applicable group purchasing organizations; and•state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws that may apply to items or services reimbursed byany third-party payor, including commercial insurers; state laws to comply with the pharmaceutical industry’s voluntary compliance guidelines andthe relevant compliance guidance promulgated by the federal government, or otherwise restrict payments that may be made to healthcare providersand other potential referral sources; state laws that require drug manufacturers to report information related to payments and other transfers of valueto physicians and other healthcare providers or marketing expenditures; and state laws governing the20privacy and security of health information in certain circumstances, many of which differ from each other in significant ways and may not have thesame effect, thus complicating compliance efforts.Because of the breadth of these laws and the narrowness of the statutory exceptions and safe harbors available, it is possible that some of ourbusiness activities could be subject to challenge under one or more of such laws. In addition, recent healthcare reform legislation has strengthened these laws.For example, the Health Care Reform Laws, among other things, amends the intent requirement of the federal anti-kickback and criminal healthcare fraudstatutes. A person or entity no longer needs to have actual knowledge of this statute or specific intent to violate it. Moreover, the Health Care Reform Lawsprovides that the government may assert that a claim including items or services resulting from a violation of the federal anti-kickback statute constitutes afalse or fraudulent claim for purposes of the False Claims Act.If our operations are found to be in violation of any of the laws described above or any other governmental regulations that apply to us, we may besubject to penalties, including civil and criminal penalties, damages, fines, exclusion from participation in government healthcare programs, such asMedicare and Medicaid, imprisonment and the curtailment or restructuring of our operations, any of which could adversely affect our ability to operate ourbusiness and our results of operations.Recently enacted and future legislation may increase the difficulty and cost needed to obtain marketing approval, and the subsequentcommercialization, of our product candidates and affect the prices we may obtain.In the United States and some foreign jurisdictions, there have been a number of legislative and regulatory changes and proposed changes regardingthe healthcare system that could prevent or delay marketing approval of our product candidates, restrict or regulate post-approval activities and affect ourability to profitably sell any product candidates for which we obtain marketing approval.For example, in 2010, President Obama signed into law the Patient Protection and Affordable Care Act, as amended by the Health Care andEducation Affordability Reconciliation Act, (collectively, the “PPACA”). Among the provisions of the PPACA of importance to our potential productcandidates are the following:•an annual, nondeductible fee on any entity that manufactures or imports specified branded prescription drugs and biologic agents;•an increase in the statutory minimum rebates a manufacturer must pay under the Medicaid Drug Rebate Program;•expansion of healthcare fraud and abuse laws, including the False Claims Act and the Anti-Kickback Statute, new government investigative powers,and enhanced penalties for noncompliance;•a new Medicare Part D coverage gap discount program, in which manufacturers must agree to offer 50% point-of-sale discounts off negotiated prices;•extension of manufacturers’ Medicaid rebate liability;•expansion of eligibility criteria for Medicaid programs;•new requirements to report financial arrangements with physicians and teaching hospitals;•a new requirement to annually report drug samples that manufacturers and distributors provide to physicians; and•a new Patient-Centered Outcomes Research Institute to oversee, identify priorities in, and conduct comparative clinical effectiveness research, alongwith funding for such research.In addition, other legislative changes have been proposed and adopted since the PPACA was enacted. These changes included aggregate reductionsof Medicare payments to providers of up to 2% per fiscal year. Additionally, in January 2013, President Obama signed into law the American Taxpayer ReliefAct of 2012, which, among other things, reduced Medicare payments to several providers, and increased the statute of limitations period for the governmentto recover overpayments to providers from three to five years. Further, while the healthcare reform agenda and policies of the new Trump administration arenot fully known, it is possible that additional regulatory changes, as well as the repeal (in whole or in part) of the PPACA, could negatively affect insurancecoverage and/or drug prices. These new laws may result in additional reductions in Medicare and other healthcare funding. We expect that the PPACA, as well as other healthcare reform measures that may be adopted in the future, may result in more rigorous coveragecriteria and additional downward pressure on the price that we receive for any approved product. Any reduction in reimbursement from Medicare or othergovernment programs may result in a similar reduction in payments21from private payers. The implementation of cost containment measures or other healthcare reforms may prevent us from being able to generate revenue, attainprofitability, or commercialize our products.Legislative and regulatory proposals have been made to expand post-approval requirements and restrict sales and promotional activities forpharmaceutical products. Additionally, legislation has been introduced to repeal the PPACA. We cannot be sure whether additional legislative changes willbe enacted, or whether the FDA regulations, guidance or interpretations will be changed, or what the impact of such changes on the marketing approvals ofour product candidates, if any, may be. In addition, increased scrutiny by the U.S. Congress of the FDA’s approval process may significantly delay or preventmarketing approval, as well as subject us to more stringent product labeling and post-marketing testing and other requirements.Governments outside the United States tend to impose strict price controls, which may adversely affect our revenues, if any.In some countries, particularly the countries of the European Union, the pricing of prescription pharmaceuticals is subject to governmental control.In these countries, pricing negotiations with governmental authorities can take considerable time after the receipt of marketing approval for a product. Toobtain reimbursement or pricing approval in some countries, we may be required to conduct a clinical trial that compares the cost-effectiveness of our productcandidate to other available therapies. If reimbursement of our products is unavailable or limited in scope or amount, or if pricing is set at unsatisfactorylevels, our business could be harmed, possibly materially.We rely on certain key employees, and the loss of their service could negatively impact our future success.We have only a small number of employees, and we rely in particular on the services of certain key employees, including George F. Tidmarsh, M.D.Ph.D., who serves as our President and Chief Executive Officer. The loss of the services of Dr. Tidmarsh or other key employees could negatively affect ourability to execute on our business plan and development activities and could cause a decline in our stock price.II. RISK FACTORS RELATED SPECIFICALLY TO OUR STOCKAs of December 31, 2016, we had approximately 18.3 million shares of common stock outstanding and currently may be required to issue up to a totalof approximately 10.7 million additional shares of common stock upon conversion of existing convertible preferred stock and upon exercise ofoutstanding stock option grants and warrants. Such an issuance would be significantly dilutive to our existing common shareholder. You will experiencefurther dilution if we issue additional equity securities in future fundraising transactions.As of December 31, 2016, there were approximately 3,906 shares of Series C-12 Convertible Preferred Stock and approximately 2,737 shares ofSeries F Convertible Preferred Stock issued and outstanding. In light of the conversion rate of our preferred stock (approximately 1,724 shares of commonstock are issuable upon the conversion of one share of Series C-12 Convertible Preferred Stock, and approximately 286 shares of common stock are issuableupon the conversion of one share of Series F Convertible Preferred Stock), the presence of such a large number of convertible preferred shares may dilute theownership of our existing shareholders and provide the preferred investors with a sizeable interest in the Company.Assuming the conversion of all preferred stock into common stock at the current conversion rates, and the exercise of all outstanding options andwarrants, we would have approximately 29.0 million shares of common stock issued and outstanding following any such conversion and exercise, althoughthe issuance of the common stock upon the conversion of our preferred stock is limited by a 9.999% beneficial ownership cap for each preferred shareholder,which such cap may be amended or waived by each such holder with no less than 61 days’ notice to the Company. With approximately 18.3 million shares ofcommon stock issued and outstanding as of December 31, 2016, the issuance of this number of shares of common stock underlying the convertible preferredstock and outstanding stock options and warrants would represent approximately 37% dilution to our existing shareholders.In addition, we may choose to raise additional capital due to market conditions or strategic considerations, even if we believe we have sufficientfunds for our current or future operating plans. To the extent that additional capital is raised through the sale of equity or convertible debt securities, theissuance of these securities could result in further dilution to our shareholders or result in downward pressure on the price of our common stock.22The price of our common stock has been, and will be, volatile and may decline.Our stock has historically experienced significant price and volume volatility and could continue to be volatile. Market prices for securities ofbiotechnology and pharmaceutical companies, including ours, have historically been highly volatile, and the market has from time to time experiencedsignificant price and volume fluctuations that are unrelated to the operating performance of particular companies. The following factors, among others, canhave a significant effect on the market price of our securities:•significant conversions of preferred stock into common stock and sales of those shares of common stock;•results from our preclinical studies and clinical trials;•limited financial resources;•announcements regarding financings, mergers or other strategic transactions;•future sales of significant amounts of our capital stock by us or our shareholders;•developments in patent or other proprietary rights;•developments concerning potential agreements with collaborators; and•general market conditions and comments by securities analysts.The realization of any of the risks described in these “Risk Factors” could have a negative effect on the market price of our common stock. Inaddition, class action litigation is sometimes instituted against companies whose securities have experienced periods of volatility in market price. Any suchlitigation brought against us could result in substantial costs and a diversion of management’s attention and resources, which could hurt our business,operating results and financial condition.Because we do not expect to pay dividends on our common stock in the foreseeable future, you must rely on stock appreciation for any return on yourinvestment.We have paid no cash dividends on our common stock to date, and we currently intend to retain our future earnings, if any, to fund the developmentand growth of our business. As a result, we do not expect to pay any cash dividends on our common stock in the foreseeable future, and payment of cashdividends, if any, will also depend on our financial condition, results of operations, capital requirements and other factors and will be at the discretion of ourboard of directors. Furthermore, we may in the future become subject to contractual restrictions on, or prohibitions against, the payment of dividends.Accordingly, the success of your investment in our common stock will likely depend entirely upon any future appreciation. There is no guarantee that ourcommon stock will appreciate in value or even maintain the price at which you purchased your shares, and you may not realize a return on your investment inour common stock.Item 1B. Unresolved Staff Comments.None.Item 2. Properties.In February 2015, the Company entered into a 32-month lease agreement, as a sublessee, for 18,599 square feet of office space to be used as theCompany’s corporate headquarters located at 10182 Telesis Court, San Diego, California. The lease term is through October 2017. The Company also leasesa total of 3,713 square feet of office space with a lease term through March 2018.In January 2016, the Company entered into a 20-month lease agreement, as a sublessee, for 24,105 square feet of lab space. The lease term is fromJanuary 2016 through August 2017, and the total lease payments through the end of the lease will be approximately $726,000. The Company also leases atotal of 4,047 square feet of lab space with a lease term through March 2017.On December 29, 2016, the Company entered into an agreement with BMR-Axiom LP to lease office and laboratory space in the building located at4550 Towne Centre Court, San Diego, California (the “Lease”) for a period of ten years commencing on or about November 1, 2017. The Lease provides anoption to extend the Lease for an additional five years at the end of the initial term, as well as an option to terminate the Lease on or before March 31, 2017,subject to certain contingencies. The annual rent under the Lease is initially $3,636,000 per annum, subject to escalation during the term. In23addition to rent, the Lease requires the Company to pay certain taxes, insurance, and operating costs relating to the leased premises. The Lease containscustomary default provisions, representations, warranties and covenants.Item 3. Legal Proceedings.In the ordinary course of business, we may face various claims brought by third parties. Any of these claims could subject us to costly litigation.However, as of the date of this report, management believes the outcome of currently identified potential claims and lawsuits will not have a material adverseeffect on our financial condition or results of operations.Item 4. Mine Safety Disclosures.None.PART IIItem 5. Market for Registrant’s Common Equity, Related Shareholder Matters and Issuer Purchases of Equity Securities.Information about Our Common StockOur common stock trades on The NASDAQ Capital Market, under the symbol “LJPC.” Set forth below are the high and low sales prices for ourcommon stock for each full quarterly period within the two most recent fiscal years. Prices High LowYear Ended December 31, 2016 First Quarter$26.44 $12.68Second Quarter$23.80 $14.24Third Quarter$28.20 $15.55Fourth Quarter$24.54 $14.63Year Ended December 31, 2015 First Quarter$24.89 $16.27Second Quarter$24.85 $14.12Third Quarter$44.99 $22.95Fourth Quarter$35.95 $21.0024Stock Performance GraphThe graph below compares the cumulative total shareholder returns on our common stock for the period starting on February 17, 2012 (the earliestdate for which stock performance data is available) through December 31, 2016 with the cumulative total shareholder returns on the NASDAQ CompositeIndex and the NASDAQ Biotechnology Index for the same period. The graph assumes that $100 was invested on February 17, 2012 in our common stock andin each index and that all dividends were reinvested. No cash dividends have been declared on our common stock. Shareholder returns over the indicatedperiod should not be considered indicative of future shareholder returns.HoldersAs of February 17, 2017, the number of shares of common stock outstanding was 18,261,557, and there were approximately 5 holders of record. Wehave approximately 4,000 beneficial holders of our common stock. DividendsWe have never paid dividends on our common stock, and we do not anticipate paying dividends in the foreseeable future.Item 6. Selected Financial Data.The following table sets forth selected historical consolidated financial data for each of our last five fiscal years during the year ended December 31,2016.Statement of Operations Data Year Ended December 31, 2016 2015 2014 2013 2012 (In thousands, except per share amounts)Total revenue$616 $1,057 $— $— $—Loss from operations$(78,372) $(41,969) $(21,340) $(17,941) $(10,739)Net loss$(78,185) $(41,912) $(21,313) $(17,935) $(7,737)Net loss attributable to common shareholders$(78,185) $(41,912) $(21,313) $(18,736) $(8,517)Basic and diluted net loss per share$(4.54) $(2.68) $(2.00) $(12.16) $(41.77)Shares used in computing basic and diluted net loss pershare17,228 15,651 10,667 1,540 20425Balance Sheet Data December 31, 2016 2015 2014 2013 2012 (In thousands)Cash and cash equivalents$65,726 $126,467 $48,555 $8,629 $3,405Working capital$57,673 $122,725 $48,177 $7,615 $3,214Total assets$70,795 $129,347 $50,536 $8,747 $3,430Total current liabilities$9,758 $4,820 $2,080 $1,094 $216Accumulated deficit$(606,711) $(528,526) $(486,614) $(465,301) $(447,366)Total shareholders’ equity$61,037 $124,527 $48,456 $7,653 $3,214Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations.IntroductionManagement’s discussion and analysis of financial condition and results of operations is provided as a supplement to the accompanyingconsolidated financial statements and notes, included in Item 15 of this Annual Report on Form 10-K, to help provide an understanding of our financialcondition, the changes in our financial condition and our results of operations. Our discussion is organized as follows:•Business Overview. This section provides a general description of our business and significant events and transactions that we believe are importantin understanding our financial condition and results of operations.•Program Overview. This section provides a current status overview for each of our product candidates in development.•Critical Accounting Policies and Estimates. This section provides a description of our significant accounting policies, including the criticalaccounting policies and estimates, which are summarized in Note 2 to the accompanying consolidated financial statements included in Item 15 ofthis Annual Report on Form 10-K.•Results of Operations. This section provides an analysis of our results of operations presented in the accompanying consolidated statements ofoperations by comparing the results for the year ended December 31, 2016 to the results for the year ended December 31, 2015 and for the yearended December 31, 2015 to the results for the year ended December 31, 2014.•Liquidity and Capital Resources. This section provides an analysis of our historical cash flows, as well as our future capital requirements.Business OverviewLa Jolla Pharmaceutical Company is a biopharmaceutical company focused on the discovery, development and commercialization of innovativetherapies intended to significantly improve outcomes in patients suffering from life-threatening diseases. We have several product candidates indevelopment. LJPC-501 is our proprietary formulation of angiotensin II for the potential treatment of catecholamine-resistant hypotension. LJPC-401 is ournovel formulation of synthetic human hepcidin for the potential treatment of conditions characterized by iron overload, such as hereditary hemochromatosis,beta thalassemia, sickle cell disease and myelodysplastic syndrome. LJPC-30S is our next-generation gentamicin derivative program that is focused ontherapeutics for the potential treatment of serious bacterial infections as well as rare genetic disorders, such as cystic fibrosis and Duchenne musculardystrophy.Program OverviewLJPC-501LJPC-501 is our proprietary formulation of angiotensin II. Angiotensin II, the major bioactive component of the renin-angiotensin system, serves asone of the body’s central regulators of blood pressure. We are developing LJPC-501 for the treatment of catecholamine-resistant hypotension (CRH), which isan acute, life-threatening condition in which blood pressure drops to dangerously low levels in patients who respond poorly to current treatments.Angiotensin II has been shown to raise blood pressure in a pilot, randomized, placebo-controlled clinical trial in CRH, which was published in thejournal Critical26Care. We have conducted preclinical pharmacology studies that have demonstrated that catecholamine resistance may be in part a result of reducedendogenous production of angiotensin II. In October 2014, we presented positive data from a preclinical study of LJPC-501 for the treatment of CRH.We initiated a Phase 3 trial of LJPC-501 for the treatment of CRH, called the ATHOS (Angiotensin II for the Treatment of High-Output Shock) 3Phase 3 trial, in March 2015. Prior to commencing the ATHOS 3 Phase 3 trial, we reached agreement with the U.S. Food and Drug Administration (FDA) on aSpecial Protocol Assessment (SPA) for this multicenter, randomized, double-blind, placebo-controlled, Phase 3 trial. In accordance with the SPA, the primaryefficacy endpoint for the ATHOS 3 Phase 3 registration trial is increase in blood pressure at three hours. In the ATHOS 3 Phase 3 trial, patients wererandomized in a 1:1 fashion to receive either: (i) LJPC-501 plus standard-of-care vasopressors; or (ii) placebo plus standard-of-care vasopressors. Randomizedpatients received their assigned treatment via continuous IV infusion for up to seven days. The primary efficacy endpoint in the trial is to compare the changein mean arterial pressure in patients with CRH who received an IV infusion of LJPC-501 plus standard-of-care vasopressors to those that received an IVinfusion of placebo plus standard-of-care vasopressors. Secondary endpoints include comparison of changes in cardiovascular Sequential Organ FailureAssessment (SOFA) scores and the safety and tolerability of LJPC-501 in patients with CRH.The ATHOS 3 Phase 3 trial completed enrollment of 344 patients in the fourth quarter of 2016. We expect to report top-line results from the ATHOS3 Phase 3 trial in the first quarter of 2017. If the results from the study are positive, we expect to file a New Drug Application (NDA) for LJPC-501 with theFDA before the end of 2017.LJPC-401LJPC-401 is our novel formulation of synthetic human hepcidin. Hepcidin, an endogenous peptide hormone, is the body’s naturally occurringregulator of iron absorption and distribution. In healthy individuals, hepcidin prevents excessive iron accumulation in vital organs, such as the liver andheart, where it can cause significant damage and even result in death.We are developing LJPC-401 for the potential treatment of iron overload, which occurs as a result of diseases such as hereditary hemochromatosis(HH), beta thalassemia, sickle cell disease (SCD) and myelodysplastic syndrome (MDS). HH is a disease characterized by a genetic deficiency in hepcidin. HHis the most common genetic disease in Caucasians and causes liver cirrhosis, liver cancer, heart disease and/or failure, diabetes, arthritis and joint pain. Betathalassemia, SCD and MDS are genetic diseases of the blood that can cause life-threatening anemia and usually require frequent and life-long bloodtransfusions. These blood transfusions cause excessive iron accumulation in the body, which is toxic to vital organs, such as the liver and heart. In addition,the underlying anemia causes excessive iron accumulation independent of blood transfusions.In September 2016, we reported positive results from a Phase 1 trial of LJPC-401 in patients at risk of iron overload suffering from HH, thalassemiaand SCD. Single, escalating doses of LJPC-401 were associated with a dose-dependent, statistically significant reduction in serum iron. LJPC-401 was welltolerated with no dose-limiting toxicities. Injection-site reactions were the most commonly reported adverse event and were all mild or moderate in severity,self-limiting, and fully resolved.Also in September 2016, we announced that we reached agreement with the European Medicines Agency (EMA) on the design of a pivotal trial ofLJPC-401. The pivotal trial will be a randomized, controlled, multicenter trial in beta thalassemia patients suffering from iron overload, a major unmet needin an orphan patient population. The primary endpoint will be a clinically relevant measurement directly related to iron overload. We plan to initiate thistrial in mid-2017. In 2015, the EMA Committee for Orphan Medicinal Products (COMP) designated LJPC-401 as an orphan medicinal product for thetreatment of beta thalassemia intermedia and major. In 2016, the EMA COMP designated LJPC-401 as an orphan medicinal product for the treatment of SCD.LJPC-30SLJPC-30S is our next-generation gentamicin derivative program. Despite kidney toxicity, gentamicin has become one of the most commonlyprescribed hospital antibiotics due to its broad spectrum of antimicrobial efficacy. Gentamicin consists primarily of a mixture of four distinct but closelyrelated chemical entities that may contribute differentially to the product’s toxicity profile.Our LJPC-30S program is focused on therapeutics derived from purified components of the currently marketed gentamicin product that retain thebiologic activity of gentamicin, yet appear to lack the traditional kidney toxicity associated27with its use. This program includes the development of potential treatments for serious bacterial infections as well as rare genetic disorders, such as cysticfibrosis and Duchenne muscular dystrophy.Gentamicin’s ability to induce a lack of fidelity in gene transcription, intrinsic to its antimicrobial mechanism of action, can also be leveraged in thecorrection of certain human genetic mutations that are the hallmark of diseases such as cystic fibrosis and Duchenne muscular dystrophy. In spite of favorableshort-term clinical proof-of-efficacy data in cystic fibrosis, development of gentamicin as a chronic treatment for these genetic diseases has been limited byits toxicity profile.Following a pre-investigational new drug (IND) meeting with the FDA, we have received guidance that we may proceed with a proposed Phase 1trial following the submission of an IND application.Critical Accounting Policies and EstimatesThe discussion and analysis of our financial condition and results of operations are based on our consolidated financial statements, which have beenprepared in accordance with U.S. generally accepted accounting principles (GAAP). The preparation of these consolidated financial statements requires us tomake estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets andliabilities. We evaluate our estimates on an ongoing basis. We base our estimates on historical experience and on other assumptions that we believe to bereasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are notreadily apparent from other sources. Actual results may differ materially from these estimates under different assumptions or conditions.We believe the following critical accounting policies involve significant judgments and estimates used in the preparation of our financialstatements (see also Note 2 to our financial statements included in Item 15 of this Annual Report on Form 10-K).Revenue RecognitionIn accordance with GAAP, we recognize revenue when all of the following criteria are met: (1) persuasive evidence of an arrangement exists;(2) delivery has occurred or services have been rendered; (3) the seller’s price to the buyer is fixed or determinable; and (4) collectibility is reasonablyassured. We currently recognize revenue from payments received under a services agreement with a related party. Under the terms of this services agreement,we receive payments from this related party for research and development services that the Company provides at what the Company believes is a negotiated,arms-length rate.Clinical Trial ExpensesPayments in connection with our clinical trials are often made under contracts with multiple contract research organizations that conduct andmanage clinical trials on our behalf. The financial terms of these agreements are subject to negotiation and vary from contract to contract and may result inuneven payment flows. Generally, these agreements set forth the scope of work to be performed at a fixed fee, unit price or on a time and materials basis.Payments under these contracts depend on factors such as the successful enrollment or treatment of patients or the completion of other clinical trialmilestones. We amortize prepayments to expense based on estimates regarding work performed, including actual level of patient enrollment, completion ofpatient studies and progress of the clinical trials.Expenses related to clinical trials are accrued based on estimates regarding work performed, including actual level of patient enrollment, completionof patient studies and progress of the clinical trials. Other incidental costs related to patient enrollment or treatment are accrued when reasonably certain. Ifthe contracted amounts are modified, the accruals are modified accordingly on a prospective basis. Revisions in the scope of a contract are charged toexpense in the period in which the facts that give rise to the revision occur.Share-based compensation We generally grant equity-based awards under our shareholder-approved, share-based compensation plans. We have granted, and may in the futuregrant, options and restricted stock awards to employees, directors, consultants and advisors under our 2013 Equity Incentive Plan. We estimate the fair value of stock options granted using the Black-Scholes option pricing model. This fair value is then amortized over therequisite service periods of the awards. The Black-Scholes option pricing model requires the input of28subjective assumptions, including each option’s expected life and the price volatility of the underlying stock. Expected volatility is based on our historicalstock price volatility. The expected life of employee stock options represents the average of the contractual term of the options and the weighted-averagevesting period, as permitted under the simplified method.Share-based compensation expense has been reduced for actual forfeitures as they occur. Changes in assumptions used under the Black-Scholesoption pricing model could materially affect our net loss and net loss per share.Recent Accounting PronouncementsRecent accounting pronouncements are disclosed in Note 2 to the accompanying financial statements included in Item 15 of this Annual Report onform 10-K.Results of OperationsThe following summarizes the results of our operations for the years ended December 31, 2016, 2015 and 2014 (in thousands): Year Ended December 31, 2016 2015 2014Contract revenue - related party$616 $1,057 $—Research and development expense(62,288) (29,092) (9,944)General and administrative expense(16,700) (13,934) (11,396)Other income, net187 57 27Net loss attributable to common shareholders$(78,185) $(41,912) $(21,313)Contract Revenue - Related PartyDuring the year ended December 31, 2015, we entered into a services agreement with a related party. Pursuant to the services agreement, we providecertain services to this related party, including, but not limited to, research and development and trial design and management for projects undertaken.Contract revenue is a function of the availability of potential projects identified by our customer and our ability and willingness to take on such projects. Assuch, this revenue may be significantly reduced in future periods, as has happened for the year ended December 31, 2016. In exchange for providing suchservices, we receive payments at a negotiated, arms-length rate. As a result, the consideration received by us for our services is considered to be no lessfavorable to us than comparable terms that we could obtain from an unaffiliated third party in an arms-length transaction. The services agreement may becanceled by either party upon 60-days’ written notice to the other party. In addition, we have a non-voting profit interest in the related party, which providesus with the potential to receive a portion of the future distributions of profits, if any.Research and Development ExpenseThe following summarizes our research and development expense for the years ended December 31, 2016, 2015 and 2014 (in thousands): Year Ended December 31, 2016 2015 2014Clinical development costs$32,798 $13,074 $5,531Personnel and related costs13,570 6,630 1,532Share-based compensation expense5,657 4,084 1,269In-licensing and technology purchase costs847 754 493Other research and development costs9,416 4,550 1,119Total research and development expense$62,288 $29,092 $9,94429Years Ended December 31, 2016 and 2015During the year ended December 31, 2016, we incurred $62.3 million in research and development expense compared to $29.1 million for the yearended December 31, 2015. The increase was primarily due to increased clinical development costs associated with the Phase 3 trial of LJPC-501 for thetreatment of CRH, clinical development costs associated with the Phase 1 trial of LJPC-401 in patients at risk of iron overload and preclinical costsassociated with the LJPC-30S program. Increases in personnel costs and share-based compensation expense associated with the support of our increaseddevelopment activities also contributed to the increase in research and development expense. We anticipate research and development expense to increasethroughout 2017, due to planned increases in personnel to support the continuation of our clinical development of LJPC-501 and LJPC-401, the initiation ofadditional clinical trials and ongoing development of our product candidates and additional programs that we have acquired.Years Ended December 31, 2015 and 2014 During the year ended December 31, 2015, we incurred $29.1 million in research and development expense compared to $9.9 million for the yearended December 31, 2014. The increase was primarily due to increased clinical development costs associated with the initiation of the Phase 3 trial of LJPC-501 for the treatment of CRH, preclinical and clinical development costs associated with the initiation of the Phase 1 trial of LJPC-401 in patients at risk ofiron overload, preclinical costs associated with LJPC-30S program and clinical development costs for the wind-down activities associated with GCS-100.Increases in personnel costs and share-based compensation expense, which were mainly due to the hiring of additional personnel to support the increaseddevelopment activities, also contributed to the increase in research and development expense. Additionally, the increase in other research and developmentcosts was partially due to increased spending for exploratory, early-stage research of $1.6 million in 2015. General and Administrative Expense The following summarizes our general and administrative expense for the years ended December 31, 2016, 2015 and 2014 (in thousands): Year Ended December 31, 2016 2015 2014Personnel and related costs$4,020 $2,458 $1,247Share-based compensation8,889 8,988 7,811Other general and administrative3,791 2,488 2,338Total general and administrative expense$16,700 $13,934 $11,396Years Ended December 31, 2016 and 2015 During the year ended December 31, 2016, we incurred $16.7 million in general and administrative expense compared to $13.9 million for the yearended December 31, 2015. The increase was primarily due to increases in personnel costs and facilities costs associated with the support of our increaseddevelopment activities. In addition, there were increased expenses for professional and outside services. We anticipate general and administrative expense toincrease throughout 2017, due to planned increases in personnel and additional facility costs to support the ongoing development of our product candidates.Years Ended December 31, 2015 and 2014During the year ended December 31, 2015, we incurred $13.9 million in general and administrative expense compared to $11.4 million for the yearended December 31, 2014. The increase was primarily due to increases in share-based compensation expense, personnel costs and facilities costs associatedwith the support of our increased development activities. In addition, there were increased expenses for professional and outside services.30Liquidity and Capital ResourcesSince January 2012, when La Jolla was effectively restarted with new assets and a new management team, through December 31, 2016, our cash usedin operating activities was $103.6 million. From inception through December 31, 2016, we have incurred a cumulative net loss of $606.7 million and havefinanced our operations through public and private offerings of securities, revenues from collaborative agreements, equipment financings and interest incomeon invested cash balances. From inception through December 31, 2016, we have raised $586.2 million in net proceeds from sales of equity securities.As of December 31, 2016, we had $65.7 million in cash and cash equivalents, compared to $126.5 million in cash and cash equivalents atDecember 31, 2015. Cash used in operating activities for the year ended December 31, 2016 was $58.7 million, compared to $25.2 million for the sameperiod in 2015. The increase was primarily due to increased research and development activities. For the year ended December 31, 2016, we used $2.2million of cash for investing activities related to purchases of property and equipment, compared to $1.8 million for the year ended December 31, 2015. AtDecember 31, 2016, we had positive working capital of $57.7 million, compared to positive working capital of $122.7 million at December 31, 2015. Thedecrease in our cash and cash equivalents and working capital was primarily due to cash used for operating and investing activities.Based on our cash and working capital as of December 31, 2016 and our current operating plans and projections, we believe that the available cashand cash equivalents will be sufficient to fund operations for at least one year from the date this annual report on Form 10-K is filed with the U.S. Securitiesand Exchange Commission. To fund future operations to the point where we are able to generate positive cash flow from the sales or out-licensing of our drugcandidates, we will need to raise additional capital. The amount and timing of future funding requirements will depend on many factors, including the timingand results of our ongoing development efforts, the potential expansion of our current development programs, potential new development programs andrelated general and administrative support, as well as the overall condition of capital markets, including capital markets for development-stage and clinical-stage biopharmaceutical companies. We anticipate that we will seek to fund our operations through public and private equity and debt financings or othersources, such as potential collaboration agreements. We cannot provide assurance that anticipated additional financing will be available to us on favorableterms, or at all. Although we have previously been successful in obtaining financing through equity securities offerings, there can be no assurance that wewill be able to do so in the future. If we are unable to raise capital on terms acceptable to us when needed, we may choose to delay or reduce otherdiscretionary spending and focus our resources on the commercialization of LJPC-501, should the clinical results warrant those resources.Off-Balance Sheet ArrangementsWe have no off-balance sheet arrangements that have, or are reasonably likely to have, a current or future effect on our financial condition, changesin our financial condition, expenses, results of operations, liquidity, capital expenditures or capital resources.Contractual ObligationsContractual obligations represent future cash commitments and liabilities under agreements with third parties. See Note 9 Commitments andContingencies in the Notes to Consolidated Financial Statements. The following table represents our contractual obligations as of December 31, 2016,aggregated by type (amounts in thousands): Payments Due by PeriodContractual Obligations Total Less Than1 Year 1 - 3 Years 3 - 5 Years More Than5 YearsLicense agreements $455 $89 $156 $90 $120Leases 1,076 1,040 36 — —Total $1,531$1,129$192$90$120Item 7A. Quantitative and Qualitative Disclosures About Market Risk.Our exposure to market risk for changes in interest rates relates primarily to interest earned on our cash equivalents and investments. The primaryobjective of our investment activities is to preserve our capital to fund operations. A secondary objective is to maximize income from our investmentswithout assuming significant risk. Our investment policy provides for investments in low-risk, investment-grade debt instruments. As of December 31, 2016,we had cash and cash equivalents of $65.7 million which includes money market funds. A hypothetical 10% change in interest rates during any of theperiods31presented would not have had a material impact on our financial statements. To date, we have not experienced a loss of principal on any of our investments.We face foreign exchange risk as a result of entering into transactions denominated in currencies other than U.S. dollars. Due to the uncertain timingof expected payments in foreign currencies, we do not utilize any forward exchange contracts. All foreign transactions settle on the applicable spot exchangebasis at the time such payments are made. An adverse movement in foreign exchange rates could have an effect on payments made to foreign suppliers andfor license agreements. A hypothetical 10% change in foreign exchange rates during any of the periods presented would not have had a material impact onour financial statements.Item 8. Financial Statements and Supplementary Data.The financial statements required by this item are set forth at the end of this Annual Report on Form 10-K beginning on page F-3 and areincorporated herein by reference.Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure.None.Item 9A. Controls and Procedures.(a) Disclosure Controls and Procedures; Changes in Internal Control Over Financial ReportingOur management, with the participation of our principal executive and principal financial officer, has evaluated the effectiveness of our disclosurecontrols and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act) as of December 31, 2016. Based on this evaluation, ourprincipal executive and principal financial officer concluded that our disclosure controls and procedures were effective as of December 31, 2016.There was no change in our internal control over financial reporting during the quarter ended December 31, 2016 that has materially affected, or isreasonably likely to materially affect, our internal control over financial reporting.(b) Management Report on Internal Control over Financial ReportingManagement is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rule 13a-15(f) of theExchange Act. Our management used the Committee of Sponsoring Organizations of the Treadway Commission Internal Control - Integrated Framework(2013) (COSO framework) to evaluate the effectiveness of internal control over financial reporting. Management believes that the COSO framework is asuitable framework for its evaluation of financial reporting because it is free from bias, permits reasonably consistent qualitative and quantitativemeasurements of our internal control over financial reporting, is sufficiently complete so that those relevant factors that would alter a conclusion about theeffectiveness of our internal control over financial reporting are not omitted and is relevant to an evaluation of internal control over financial reporting. Management has assessed the effectiveness of our internal control over financial reporting as of December 31, 2016 and has concluded that suchinternal control over financial reporting was effective.Our independent registered public accounting firm, Squar Milner LLP, has audited the financial statements included in this Annual Report on Form10-K and has issued a report on the effectiveness of our internal control over financial reporting. The report of Squar Milner LLP is incorporated by referencefrom Item 8 of this Annual Report on Form 10-K.Item 9B. Other Information.None.32PART IIIItem 10. Directors, Executive Officer and Corporate Governance.The information required by this Item is expected to be in our definitive Proxy Statement for the 2017 Annual Meeting of Shareholders, which weexpect to be filed with the SEC within 120 days of the end of our fiscal year ended December 31, 2016 and is incorporated herein by reference.We have adopted a Code of Business Conduct and Ethics that applies to all of our directors, officers and employees, including our principalexecutive, principal financial and principal accounting officers, or persons performing similar functions. Our Code of Business Conduct and Ethics is postedon our website located at http://www.lajollapharmaceutical.com in the Corporate Governance section under “Investor Relations”. We intend to disclosefuture amendments to certain provisions of the Code of Business Conduct and Ethics, and waivers of the Code of Business Conduct and Ethics granted toexecutive officers and directors, on the website within four business days following the date of the amendment or waiver.Item 11. Executive Compensation.The information required by this Item is expected to be in our definitive Proxy Statement for the 2017 Annual Meeting of Shareholders, which weexpect to be filed with the SEC within 120 days of the end of our fiscal year ended December 31, 2016 and is incorporated herein by reference.Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Shareholder Matters. The information required by this Item is expected to be in our definitive Proxy Statement for the 2017 Annual Meeting of Shareholders, which weexpect to be filed with the SEC within 120 days of the end of our fiscal year ended December 31, 2016 and is incorporated herein by reference.Item 13. Certain Relationships and Related Transactions, and Director Independence.The information required by this Item is expected to be in our definitive Proxy Statement for the 2017 Annual Meeting of Shareholders, which weexpect to be filed with the SEC within 120 days of the end of our fiscal year ended December 31, 2016 and is incorporated herein by reference.Item 14. Principal Accountant Fees and Services.The information required by this Item is expected to be in our definitive Proxy Statement for the 2017 Annual Meeting of Shareholders, which weexpect to be filed with the SEC within 120 days of the end of our fiscal year ended December 31, 2016 and is incorporated herein by reference.33PART IVItem 15. Exhibits, Financial Statement Schedules.(a) Documents filed as part of this report.1.The following financial statements of La Jolla Pharmaceutical Company are filed as part of this report under Item 8 — Financial Statements andSupplementary Data:Report of Independent Registered Public Accounting Firm - Financial StatementsF - 1 Report of Independent Registered Public Accounting Firm - Internal Control over Financial ReportingF - 2 Consolidated Balance Sheets at December 31, 2016 and 2015F - 3 Consolidated Statements of Operations for the years ended December 31, 2016, 2015 and 2014F - 4 Consolidated Statements of Shareholders’ Equity for the years ended December 31, 2016, 2015 and 2014F - 5 Consolidated Statements of Cash Flows for the years ended December 31, 2016, 2015 and 2014F - 6 Notes to Consolidated Financial StatementsF - 72.Financial Statement Schedules.The following financial statement schedules of La Jolla Pharmaceutical Company are filed as part of this report under Item 8 — Financial Statementsand Supplementary Data.3.Exhibits.List of Exhibit required by Item 601 of Regulation S-K. See part (b) below.(b) Exhibits: Incorporated by Reference ExhibitNo. ExhibitDescription Form DateFiled FiledHerewith 3.1.1 Amended and Restated Articles of Incorporation S-8 12/20/2013 3.1.2 Certificate of Amendment of Articles of Incorporation 8-K 1/15/2014 3.1.3 Certificate of Amendment to Amend and Restated Articles of Incorporation 8-A12B/A 10/17/2014 3.2 Amended and Restated Bylaws 8-A12B/A 10/17/2014 4.1 Certificate of Determination of Series F Convertible Preferred Stock 8-K 9/25/2013 4.2 Form of Series C-2 Preferred Stock Purchase Warrant 8-K 5/28/2010 4.3 Form of Series D-1 Preferred Stock Purchase Warrant 8-K 5/28/2010 10.1* Form of Indemnification Agreement 10-Q 11/17/2005 10.7* Employment Offer Letter by and between La Jolla Pharmaceutical Company and George F.Tidmarsh, M.D., Ph.D., dated as of January 19, 2012 8-K 1/20/2012 10.8 Securities Purchase Agreement, dated as of September 24, 2013, by and among La JollaPharmaceutical Company and the Purchasers named therein 8-K 9/25/2013 10.9 Consent and Waiver Agreement, dated as of September 24, 2013, by and among La JollaPharmaceutical Company and the parties thereto 8-K 9/25/2013 10.10 Exchange Agreement, dated as of September 25, 2013, by and among La Jolla PharmaceuticalCompany and the parties thereto 8-K 9/25/2013 3410.11* La Jolla Pharmaceutical Company 2013 Equity Incentive Plan 8-K 9/25/2013 10.12* Employment Offer Letter by and between La Jolla Pharmaceutical Company and LakhmirChawla, M.D., dated as of February 3, 2015 10-K 2/25/2016 10.13* Employment Offer Letter by and between La Jolla Pharmaceutical Company and DennisMulroy dated as of March 12, 2015 8-K 4/10/2015 10.14* Employment Offer Letter by and between La Jolla Pharmaceutical Company and Jennifer AnneCarver dated January 1, 2016 10-K 2/25/2016 10.15 Lease between BMR-Axiom LP and La Jolla Pharmaceutical Company, dated December 29,2016 X 21.1 Subsidiaries of La Jolla Pharmaceutical Company X 23.1 Consent of Independent Registered Public Accounting Firm Squar Milner LLP X 24.1 Power of Attorney (included on the signature page of this Form 10-K) X 31.1 Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 X 31.2 Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 X 32.1 Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 X 101.INS XBRL Instance Document X 101.SCH XBRL Taxonomy Extension Schema Document X 101.CAL XBRL Taxonomy Extension Calculation Linkbase Document X 101.DEF XBRL Taxonomy Extension Definition Linkbase Document X 101.LAB XBRL Taxonomy Extension Label Linkbase Document X 101.PRE XBRL Taxonomy Extension Presentation Linkbase Document X*This exhibit is a management contract or compensatory plan or arrangement.35SIGNATURESPursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by theundersigned hereunto duly authorized. La Jolla Pharmaceutical Company Date:February 23, 2017/s/ George F. Tidmarsh George F. Tidmarsh, M.D., Ph.D. President, Chief Executive Officer and Secretary (Principal Executive Officer)POWER OF ATTORNEYKNOW ALL MEN BY THESE PRESENT, that each person whose signature appears below constitutes and appoints each of George F. Tidmarsh,M.D., Ph.D. and Dennis M. Mulroy as his or her true and lawful attorney-in-fact and agent, with full power of substitution for him or her, and in his or hername in any and all capacities, to sign any and all amendments to this Annual Report on Form 10-K, and to file the same, with exhibits thereto and otherdocuments in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority todo and perform each and every act and thing requisite and necessary to be done therewith, as fully to all intents and purposes as he might or could do inperson, hereby ratifying and confirming all that said attorney-in-fact and agent, his substitute or substitutes, may lawfully do or cause to be done by virtuehereof.Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of theregistrant and in the capacities and on the dates indicated.Signature Title Date/s/ George F. Tidmarsh Director, President, Chief Executive Officer and Secretary (PrincipalExecutive Officer) February 23, 2017George F. Tidmarsh, M.D., Ph.D. /s/ Dennis M. Mulroy Chief Financial Officer(Principal Financial and Accounting Officer) February 23, 2017Dennis M. Mulroy /s/ Kevin C. Tang Chairman of the Board and Director February 23, 2017Kevin C. Tang /s/ Laura L. Douglass Director February 23, 2017Laura L. Douglass /s/ Craig A. Johnson Director February 23, 2017Craig A. Johnson /s/ Robert H. Rosen Director February 23, 2017Robert H. Rosen 36REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMTo the Board of Directors and Shareholders ofLa Jolla Pharmaceutical CompanyWe have audited the accompanying consolidated balance sheets of La Jolla Pharmaceutical Company (and subsidiaries) as of December 31, 2016 and 2015,and the related consolidated statements of operations, shareholders’ equity, and cash flows for each of the three years in the period ended December 31, 2016.These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statementsbased on our audits.We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require thatwe plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includesexamining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accountingprinciples used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our auditsprovide a reasonable basis for our opinion.In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of La Jolla PharmaceuticalCompany as of December 31, 2016 and 2015, and the results of their operations and their cash flows for each of the three years in the period ended December31, 2016, in conformity with U.S. generally accepted accounting principles.We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), La Jolla PharmaceuticalCompany’s (and subsidiaries) internal control over financial reporting as of December 31, 2016, based on criteria established in Internal Control-IntegratedFramework issued by the Committee of Sponsoring Organizations of the Treadway Commission in 2013, and our report dated February 23, 2017 expressed anunqualified opinion on the effectiveness of La Jolla Pharmaceutical Company’s internal control over financial reporting./s/ SQUAR MILNER LLPSan Diego, CaliforniaFebruary 23, 2017F - 1REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMTo the Board of Directors and Shareholders ofLa Jolla Pharmaceutical CompanyWe have audited La Jolla Pharmaceutical Company’s internal control over financial reporting as of December 31, 2016, based on criteria established inInternal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission in 2013. La Jolla PharmaceuticalCompany’s management is responsible for maintaining effective internal control over financial reporting, and for its assessment of the effectiveness ofinternal control over financial reporting included in the accompanying Management Report on Internal Control over Financial Reporting at Item 9A. Ourresponsibility is to express an opinion on the Company’s internal control over financial reporting based on our audit.We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require thatwe plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all materialrespects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, andtesting and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audit also included performing such otherprocedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reportingand the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal controlover financial reporting includes those policies and procedures that (a) pertain to the maintenance of records that, in reasonable detail, accurately and fairlyreflect the transactions and dispositions of the assets of the company; (b) provide reasonable assurance that transactions are recorded as necessary to permitpreparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are beingmade only in accordance with authorizations of management and directors of the company; and (c) provide reasonable assurance regarding prevention ortimely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation ofeffectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliancewith the policies or procedures may deteriorate.In our opinion, La Jolla Pharmaceutical Company maintained, in all material respects, effective internal control over financial reporting as of December 31,2016, based on criteria established in Internal Control - Integrated Framework issued by the Committee of Sponsoring Organizations of the TreadwayCommission in 2013.We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the 2016 consolidated financialstatements of La Jolla Pharmaceutical Company and our report dated February 23, 2017 expressed an unqualified opinion./s/ SQUAR MILNER LLPSan Diego, CaliforniaFebruary 23, 2017F - 2LA JOLLA PHARMACEUTICAL COMPANYConsolidated Balance Sheets(in thousands, except share and par value amounts) December 31, 2016 December 31, 2015ASSETS Current assets: Cash and cash equivalents$65,726 $126,467Restricted cash200 237Prepaid clinical expenses67 223Prepaid expenses and other current assets1,438 618Total current assets67,431 127,545Property and equipment, net3,145 1,732Other assets219 70Total assets$70,795 $129,347 LIABILITIES AND SHAREHOLDERS’ EQUITY Current liabilities: Accounts payable$6,652 $3,052Accrued clinical and other expenses1,029 678Accrued payroll and related expenses2,077 1,090Total current liabilities9,758 4,820Commitments and contingencies Shareholders’ equity: Common Stock, $0.0001 par value; 100,000,000 shares authorized, 18,261,557 and 18,244,009 shares issued andoutstanding at December 31, 2016 and December 31, 2015, respectively2 2Series C-12 Convertible Preferred Stock, $0.0001 par value; 11,000 shares authorized, 3,906 shares issued andoutstanding at December 31, 2016 and December 31, 2015, and a liquidation preference of $3,906 at December31, 2016 and 20153,906 3,906Series F Convertible Preferred Stock, $0.0001 par value; 10,000 shares authorized, 2,737 shares issued andoutstanding at December 31, 2016 and December 31, 2015, and liquidation preference of $2,737 at December 31,2016 and 20152,737 2,737Additional paid-in capital661,103 646,408Accumulated deficit(606,711) (528,526)Total shareholders’ equity61,037 124,527Total liabilities and shareholders’ equity$70,795 $129,347See accompanying notes to the consolidated financial statements.F - 3LA JOLLA PHARMACEUTICAL COMPANYConsolidated Statements of Operations(in thousands, except per share amounts) Year Ended December 31, 2016 2015 2014Revenue Contract revenue - related party$616 $1,057 $—Total revenue616 1,057 —Expenses Research and development62,288 29,092 9,944General and administrative16,700 13,934 11,396Total expenses78,988 43,026 21,340Loss from operations(78,372) (41,969) (21,340)Other income, net187 57 27Net loss(78,185) (41,912) (21,313)Net loss attributable to common shareholders$(78,185) $(41,912) $(21,313)Basic and diluted net loss per share$(4.54) $(2.68) $(2.00)Shares used in computing basic and diluted net loss per share17,228 15,651 10,667See accompanying notes to the consolidated financial statements.F - 4La Jolla Pharmaceutical CompanyConsolidated Statements of Shareholders’ EquityFor the Years Ended December 31, 2016, 2015 and 2014(in thousands) Series C-12ConvertiblePreferred Stock Series F ConvertiblePreferred Stock Common Stock AdditionalPaid-inCapital AccumulatedDeficit TotalShareholders’Equity Shares Amount Shares Amount Shares Amount Balance at December 31, 2013 7 $7,016 3 $3,250 4,404 $4 $462,684 $(465,301) $7,653Adjustment for reverse stock split — — — — — (4) 4 — —Issuance of common stock for July 2014 financing — — — — 5,395 1 53,062 — 53,063Conversion of Series F Convertible Preferred Stock into common stock — — — (452) 129 — 452 — —Conversion of Series C-12 Convertible Preferred Stock into common stock (3) (3,099) — — 5,342 1 3,098 — —Share-based compensation expense — — — — — — 8,992 — 8,992Third party share-based compensation expense — — — — — — 63 — 63Common stock issued for services — — — — 3 — 25 — 25Restricted stock awards canceled — — — — (47) — (27) — (27)Net loss — — — — — — — (21,313) (21,313)Balance at December 31, 2014 4 3,917 3 2,798 15,226 2 528,353 (486,614) 48,456Issuance of common stock for September 2015 financing — — — — 2,933 — 104,596 — 104,596Conversion of Series F Convertible Preferred Stock into common stock — — — (61) 17 — 61 — —Conversion of Series C-12 Convertible Preferred Stock into common stock — (11) — — 19 — 11 — —Share-based compensation expense — — — — — — 11,551 — 11,551Third party share-based compensation expense — — — — — — 1,521 — 1,521Exercise of stock options for common stock — — — — 45 — 315 — 315Issuance of restricted stock awards — — — — 4 — — — —Net loss — — — — — — — (41,912) (41,912)Balance at December 31, 2015 4 3,906 3 2,737 18,244 $2 646,408 (528,526) 124,527Share-based compensation expense — — — — — — 14,349 — 14,349Third party share-based compensation expense — — — — — — 197 — 197Exercise of stock options for common stock — — — — 17 — 149 — 149Net loss — — — — — — — $(78,185) (78,185)Balance at December 31, 2016 4 $3,9063$2,73718,261$2$661,103$(606,711)$61,037See accompanying notes to the consolidated financial statements.F - 5LA JOLLA PHARMACEUTICAL COMPANYConsolidated Statements of Cash Flows(in thousands) Year Ended December 31, 2016 2015 2014Operating activities Net loss$(78,185) $(41,912) $(21,313)Adjustments to reconcile net loss to net cash used for operating activities: Share-based compensation expense14,349 11,551 8,992Third party share-based compensation expense197 1,521 63Issuance of common stock for services— — 25Depreciation expense730 347 17Loss on disposal75 16 —Changes in operating assets and liabilities: Restricted cash37 (200) —Prepaid clinical expenses156 1,305 (1,528)Prepaid expenses and other current assets(820) (481) (94)Other assets(149) (70) —Accounts payable3,600 2,322 (104)Accrued clinical and other expenses351 (248) 739Accrued payroll and related expenses987 666 324Net cash used for operating activities(58,672) (25,183) (12,879) Investing activities Purchase of property and equipment(2,218) (1,816) (258)Net cash used for investing activities(2,218) (1,816) (258) Financing activities Net proceeds from the issuance of common stock— 104,596 53,063Net proceeds from the exercise of stock options for common stock149 315 —Proceeds from the issuance of Series F Convertible Preferred Stock— — —Net cash provided by financing activities149 104,911 53,063 Net (decrease) increase in cash and cash equivalents(60,741) 77,912 39,926Cash and cash equivalents at beginning of period126,467 48,555 8,629Cash and cash equivalents at end of period$65,726 $126,467 $48,555 Supplemental disclosure of cash flow information Non-cash investing and financing activity: Conversion of Series C-12 Convertible Preferred Stock into common stock$— $11 $—Conversion of Series F Convertible Preferred Stock into common stock$— $61 $452Conversion of Series C-12 and D-12 Convertible Preferred Stock into common stock$— $— $3,099See accompanying notes to the consolidated financial statements.F - 6La Jolla Pharmaceutical CompanyNotes to Consolidated Financial Statements1. BusinessLa Jolla Pharmaceutical Company (collectively with its subsidiaries, the “Company”) is a biopharmaceutical company focused on the discovery,development and commercialization of innovative therapies intended to significantly improve outcomes in patients suffering from life-threatening diseases.The Company has several product candidates in development. LJPC-501 is the Company’s proprietary formulation of angiotensin II for the potentialtreatment of catecholamine-resistant hypotension. LJPC-401 is the Company’s novel formulation of synthetic human hepcidin for the potential treatment ofconditions characterized by iron overload, such as hereditary hemochromatosis, beta thalassemia, sickle cell disease and myelodysplastic syndrome. LJPC-30S is the Company’s next-generation gentamicin derivative program that is focused on therapeutics for the potential treatment of serious bacterial infectionsas well as rare genetic disorders, such as cystic fibrosis and Duchenne muscular dystrophy. The Company was incorporated in 1989 as a Delaware corporationand reincorporated in California in 2012.As of December 31, 2016, we had $65.7 million in cash and cash equivalents, compared to $126.5 million in cash and cash equivalents atDecember 31, 2015. The Company has a history of incurring significant operating losses and negative cash flows from operations. Based on our cash andworking capital as of December 31, 2016 and our current operating plans and projections, we believe that the available cash and cash equivalents will besufficient to fund operations for at least one year from the date this annual report on Form 10-K is filed with the U.S. Securities and Exchange Commission.To fund future operations to the point where we are able to generate positive cash flow from the sales or out-licensing of our drug candidates, we will need toraise additional capital. The amount and timing of future funding requirements will depend on many factors, including the timing and results of our ongoingdevelopment efforts, the potential expansion of our current development programs, potential new development programs and related general andadministrative support, as well as the overall condition of capital markets, including capital markets for development-stage and clinical-stagebiopharmaceutical companies. We anticipate that we will seek to fund our operations through public and private equity and debt financings or other sources,such as potential collaboration agreements. We cannot provide assurance that anticipated additional financing will be available to us on favorable terms, orat all. Although we have previously been successful in obtaining financing through equity securities offerings, there can be no assurance that we will be ableto do so in the future. If we are unable to raise capital on terms acceptable to us when needed, we may choose to delay or reduce other discretionary spendingand focus our resources on the commercialization of LJPC-501, should the clinical results warrant those resources.2. Summary of Significant Accounting PoliciesBasis of Presentation and Use of EstimatesThe consolidated financial statements of the Company have been prepared in accordance with U.S. generally accepted accounting principles(GAAP) and include the accounts of the Company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated inconsolidation. The preparation of financial statements requires that management make estimates and assumptions that affect the reported amounts of assets,liabilities, revenues, expenses and related disclosures. Actual results could differ materially from those estimates.Certain amounts previously reported in the financial statements have been reclassified to conform to the current year presentation. Suchreclassifications did not affect net loss, shareholders’ equity or cash flows.Cash and Cash EquivalentsThe Company considers all highly liquid investments with a maturity from the date of purchase of less than three months to be cash equivalents. Thecarrying value of the Company’s money market funds is included in cash equivalents and approximates the fair value.Restricted CashUnder the terms of the Company’s credit card arrangements, there is a requirement to maintain a collateral cash account pledged as security for suchcredit cards. Previously under the terms of the leases of certain of the Company’s facilities, there was a requirement to maintain a certificate of deposit assecurity during the terms of such leases.F - 7La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsConcentrations of Credit RiskFinancial instruments that potentially subject the Company to concentrations of credit risk consist primarily of cash equivalents. The Companyinvests excess cash in money market accounts. This diversification of risk is consistent with the Company's policy to ensure safety of principal and maintainliquidity.Property and EquipmentProperty and equipment is stated at cost less accumulated depreciation. Depreciation is computed using the straight-line method over the estimateduseful lives of the assets, which range from two to seven years. Amortization of leasehold improvements is recorded over the shorter of the lease term or theestimated useful life of the related assets. Maintenance and repairs are charged to operations as incurred. When assets are sold, or otherwise disposed of, thecost and related accumulated depreciation are removed from the accounts and any gain or loss is included in other income or expense.Revenue RecognitionThe Company recognizes revenue when all of the following criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery hasoccurred or services have been rendered; (3) the seller’s price to the buyer is fixed or determinable; and (4) collectibility is reasonably assured. The Companycurrently recognizes revenue from payments received under a services agreement with a related party. Under the terms of this services agreement, theCompany receives payments from this related party for research and development services that the Company provides at a negotiated, arms-length rate.Clinical Trial ExpensesPayments in connection with the Company’s clinical trials are often made under contracts with multiple contract research organizations that conductand manage clinical trials on the Company’s behalf. The financial terms of these contracts are subject to negotiation, vary from contract to contract and mayresult in uneven payment flows. Generally, these contracts set forth the scope of work to be performed at a fixed fee, unit price or on a time and materialsbasis. Payments under these contracts depend on factors such as the successful enrollment or treatment of patients or the completion of other clinical trialmilestones. The Company amortizes prepaid clinical trial costs to expense based on estimates regarding work performed, including actual level of patientenrollment, completion of patient studies and progress of the clinical trials.Expenses related to clinical trials are accrued based on estimates regarding work performed, including actual level of patient enrollment, completionof patient studies and progress of the clinical trials. Other incidental costs related to patient enrollment or treatment are accrued when reasonably certain. Ifthe contracted amounts are modified, the accruals are modified accordingly on a prospective basis. Revisions in the scope of a contract are charged toexpense in the period in which the facts that give rise to the revision occur.Research and Development ExpensesResearch and development expenses include salaries and benefits, facilities and other overhead expenses, research-related manufacturing expenses,contract services and clinical and preclinical-related services performed by clinical research organizations, research institutions and other outside serviceproviders. Research and development expenses are charged to operations as incurred when these expenditures relate to the Company’s research anddevelopment efforts and have no alternative future uses.In accordance with certain research and development agreements, the Company is obligated to make certain upfront payments upon execution of theagreement. Advance payments, including nonrefundable amounts, for materials or services that will be used or rendered for future research and developmentactivities are deferred and capitalized. Such amounts are recognized as an expense as the related goods are delivered or the related services are performed.Acquisition or milestone payments that the Company makes in connection with in-licensed technology are expensed as incurred when there isuncertainty in receiving future economic benefits from the licensed technology. The Company considers the future economic benefits from the licensedtechnology to be uncertain until such licensed technology is incorporated into products that are approved for marketing by the U.S. Food and DrugAdministration (FDA) or when other significant risk factors are abated. For accounting purposes, management has viewed future economic benefits for all ofthe Company’s licensed technology to be uncertain.F - 8La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsPatent CostsLegal costs in connection with approved patents and patent applications are expensed as incurred, as recoverability of such expenditures isuncertain. These costs are recorded in research and development in the consolidated statement of operations and comprehensive loss.Share-Based CompensationThe Company accounts for share-based payment arrangements in accordance with Accounting Standards Codification (ASC) 718, Compensation -Stock Compensation and ASC 505-50, Equity - Equity Based Payments to Non-Employees, which requires the recognition of compensation expense, using afair-value based method, for all costs related to share-based payments, including stock options and restricted stock awards. These standards require companiesto estimate the fair value of share-based payment awards on the date of the grant using an option-pricing model. The Company has elected to account forforfeitures as they occur. See Note 6 for further discussion of the Company’s share-based compensation plans.Income TaxesThe Company accounts for income taxes and the related accounts under the liability method. Deferred tax assets and liabilities are determined basedon the differences between the financial statement carrying amounts and the income tax basis of assets and liabilities. A valuation allowance is appliedagainst any net deferred tax asset if, based on available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized.Net Loss Per ShareBasic net loss per share is calculated based on the weighted-average number of common shares outstanding, excluding unvested restricted stockawards. Diluted net loss per share is calculated using the weighted-average number of common shares outstanding plus common stock equivalents.Convertible preferred stock, stock options, warrants and unvested restricted stock awards are considered common stock equivalents and are included in thecalculation of diluted net loss per share using the treasury stock method when their effect is dilutive. Common stock equivalents are excluded from thecalculation of diluted net loss per share when their effective is anti-dilutive. As of December 31, 2016, 2015, and 2014, there were common stock equivalentsof 10.7 million shares, 10.0 million shares, 8.2 million shares, respectively. Common stock equivalents were excluded from the calculation of diluted net lossper share because they were anti-dilutive.Comprehensive LossComprehensive loss for the periods reported was comprised solely of the Company’s net loss. The comprehensive loss for the years endedDecember 31, 2016, 2015 and 2014, was $78.2 million, $41.9 million and $21.3 million, respectively. There were no other changes in equity that wereexcluded from net loss for all periods presented.Segment ReportingManagement has determined that the Company operates in one business segment, which includes all activities related to the research, developmentand commercialization of its proprietary technologies and drug candidates for pharmaceutical products.Fair Value MeasurementsThe Company follows the provisions of ASC 820-10, Fair Value Measurements and Disclosures, which defines fair value, establishes a framework formeasuring fair value in generally accepted accounting principles and requires certain disclosures about fair value measurements. Broadly, the ASC 820-10framework clarifies that fair value is an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderlytransaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that marketparticipants would use in pricing an asset or liability.As a basis for considering such assumptions, ASC 820-10 establishes a three tier value hierarchy which prioritizes the inputs used in measuring fairvalue as follows: Level 1) observable inputs such as quoted prices in active markets; Level 2) inputs other than the quoted prices in active markets that areobservable either directly or indirectly; and Level 3) unobservable inputs in which there is little or no market data, which require us to develop our ownassumptions. The hierarchy requires theF - 9La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsCompany to use observable market data, when available, and to minimize the use of unobservable inputs when determining fair value.Cash equivalents consist of money market accounts with maturities of ninety days or less. Due to the high ratings and short-term nature of thesefunds, the Company considers the values of all cash equivalents as Level 1 inputs.The Company’s financial instruments include cash equivalents, prepaid expenses, accounts payable and accrued expenses. The carrying amountsreported in the balance sheets for cash equivalents, prepaid expenses, accounts payable and accrued expenses approximate fair values because of the short-term nature of these instruments.Recent Accounting PronouncementsIn January 2017, the Financial Accounting Standards Board (FASB) issued Accounting Standard Update (ASU) 2017-01, Business Combinations(Topic 805) - Clarifying the Definition of a Business. The new standard provides guidance to assist entities when evaluating whether transactions should beaccounted for as acquisitions or disposals of assets or businesses. The Company has adopted ASU 2017-01 early effective for the year ended December 31,2016. Early adoption is permitted for transactions for which the acquisition date occurred before the issuance date of the ASU, but before the transaction hasbeen reported in issued financial statements. The Company entered into an asset purchase transaction in November 2016 and has applied the guidance inASU 2017-01 due to the improved clarification for the definition of a business. The adoption of this standard did not have a material impact on theCompany's financial position or results of operations.In November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash. The new standard update clarifies thepresentation of restricted cash and requires companies to include restricted cash and cash equivalents in the beginning and ending cash on the statement ofcash flows. Additional disclosures will be required to describe the amount and detail of the restriction by balance sheet line item. ASU 2016-18 will beeffective for the Company in the first quarter of 2018. Early adoption is permitted, including adoption in an interim period using a retrospective transitionmethod to each period presented. The Company is currently evaluating the impact of this standard on its consolidated financial statements.In March 2016, the FASB issued ASU 2016-09, Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-BasedPayment Accounting. The new standard modifies multiple provisions intended to simplify various aspects of accounting for share-based payments includingincome tax consequences, accounting for forfeitures, classification of awards as either equity or liabilities, and classification on the statement of cash flows.The amendments in this ASU will be effective for the Company in the first quarter of 2017, but the Company has elected to early adopt ASU 2016-09 in thefourth quarter of 2016, which requires that any adjustments be reflected as of January 1, 2016. An entity that elects early adoption must adopt all of theamendments in the same period. The Company has elected to recognize forfeitures of awards as they occur. The Company has not estimated forfeitures inprior years due to no prior history of forfeitures. The Company is recognizing forfeitures prospectively beginning in 2016, which coincides with the firstoccurrence of forfeitures. The adoption of this standard did not have a material impact on the Company’s financial position or results of operations, includingno impact for the other simplification aspects of ASU 2016-09 regarding income tax consequences, classification of awards as either equity or liabilities, andclassification on the statement of cash flows.In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). The new standard requires lessees to recognize most leases on their balancesheets as lease liabilities with corresponding right-of-use assets and eliminates certain real estate-specific provisions. ASU 2016-02 will be effective for theCompany in the first quarter of 2019 and will be adopted on a modified retrospective transition basis for leases existing at, or entered into after, the beginningof the earliest comparative period presented in the financial statements. The Company currently plans to implement ASU 2016-02 in the first quarter of 2019.In 2019, all of the Company’s active existing leases will have ended prior to 2019. Those leases will not have an impact on the consolidated financialstatements upon adoption in 2019, and there will be no requirement for modified retrospective application to the years prior to adoption. In December 2016,the Company entered into a 10-year lease agreement for corporate headquarters with an option to terminate the lease early, subject to certain contingencies.The expected lease commencement date is November 1, 2017. If the contingency is removed and the termination option is not exercised, this lease would berecognized on the balance sheet as a lease liability with a corresponding right-of-use asset, which would require modified retrospective application uponadoption in 2019 back to the fourth quarter of 2017.In August 2014, the FASB issued ASU 2014-15, Presentation of Financial Statements - Going Concern (Subtopic 205-40): Disclosure ofUncertainties about an Entity’s Ability to Continue as a Going Concern. The new standard requires management to assess, at each annual and interimreporting period, an entity’s ability to continue as a going concern within oneF - 10La Jolla Pharmaceutical CompanyNotes to Consolidated Financial Statementsyear after the date that the financial statements are issued and to provide related footnote disclosures. The Company adopted ASU 2014-15 for the year endedDecember 31, 2016. The adoption of this standard had no material impact on the Company’s financial position or results of operations.In June 2014, the FASB issued ASU 2014-12, Compensation - Stock Compensation (Topic 718): Accounting for Share-Based Payments When theTerms of an Award Provide that a Performance Target Could be Achieved after the Requisite Service Period. The new standard requires that a performancetarget that affects vesting and that could be achieved after the requisite service period be treated as a performance condition. As such, the performance targetshould not be reflected in estimating the grant date fair value of the award. Compensation cost should be recognized in the period in which it becomesprobable that the performance target will be achieved and should represent the compensation cost attributable to the periods for which the requisite servicehas already been rendered. The Company adopted ASU 2014-12 effective as of January 1, 2016, and the adoption of this standard had no impact on theCompany’s financial position or results of operations.In May 2014, the FASB issued ASU 2014-09, Revenue from Contracts with Customers (Topic 606). The new standard is based on the principle thatrevenue should be recognized to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which theentity expects to be entitled in exchange for those goods or services. ASU 2014-09 will be effective for the Company in the first quarter of 2018 and allowsfor full retrospective or a modified retrospective adoption approach. We currently do not have any products or revenues from customers, and the adoption ofthis standard will not have a material impact on the Company’s financial position or results of operations. The Company plans on adopting the ASUprospectively upon recognition of the first revenue from customers, and there will not be any impact retrospectively or modified retrospectively to ourfinancial statements. The Contract Revenue - Related Party reported in our results of operations for 2015 and 2016, which represents expense reimbursementsfrom a related party, would not be affected by the adoption of the new guidance.3. Balance Sheet Account DetailsProperty and EquipmentProperty and equipment, net consists of the following (in thousands): December 31, 2016 2015Computer Hardware$457 $389Software309 34Lab equipment2,610 978Furniture and fixtures389 314Leasehold improvements464 393Total property and equipment, gross4,229 2,108Accumulated depreciation(1,084) (376)Total property and equipment, net$3,145 $1,732Accrued Clinical and Other ExpensesAccrued clinical and other expenses consist of the following (in thousands): December 31, 2016 2015Accrued clinical trials$828 $629Accrued other201 49Total accrued clinical and other expenses$1,029 $678F - 11La Jolla Pharmaceutical CompanyNotes to Consolidated Financial Statements4. Licensed TechnologyThe George Washington UniversityIn December 2014, the Company entered into a patent license agreement with the George Washington University (GW). Pursuant to this licenseagreement, GW exclusively licensed to the Company certain intellectual property rights relating to LJPC-501 (501 IP Rights). Under this license agreement,the Company paid a one-time license initiation fee of $250,000, which is included in research and development expense for the year ended December 31,2014. Additional payments are due upon the achievement of certain development and regulatory milestones and for royalties on products covered by the 501IP Rights.Inserm Transfert SAIn February 2014, the Company entered into a license agreement with Inserm Transfert SA (Inserm). Pursuant to this license agreement, Insermexclusively licensed to the Company certain intellectual property rights relating to LJPC-401 (401 IP Rights). Under this license agreement, the Companypaid a one-time license initiation fee of approximately $140,000, which is included in research and development expense for the year ended December 31,2014. Additional payments are due upon the achievement of certain development and regulatory milestones and for royalties on products covered by the 401IP Rights.Other In-Licensed TechnologyThe Company continues to seek additional technology for potential new development programs and, as a result, has entered into various licensingagreements for intellectual property rights. In 2015, the Company formed foreign subsidiaries to acquire and in-license various early-stage technology fromIndiana University Research and Technology Corporation, Vanderbilt University and the Board of Trustees of the Leland Stanford Junior University.The Company has incurred licensing and milestone fees of $521,000, $754,000 and $493,000 recorded in research and development expenses inconnection with its licensing agreements for the years ended December 31, 2016, 2015 and 2014, respectively.5. Contract Revenue - Related PartyDuring the year ended December 31, 2015, the Company entered into a services agreement with a related party. Pursuant to the services agreement,the Company provides certain services to this related party, including, but not limited to, research and development and trial design and management forprojects undertaken. In exchange for providing such services, the Company is entitled to receive payments at a negotiated, arms-length rate. As a result, theconsideration received by the Company for its services is considered to be no less favorable to the Company than comparable terms that the Company couldobtain from an unaffiliated third party in an arms-length transaction. The services agreement may be canceled by either party upon 60-days’ written notice tothe other party.During the years ended December 31, 2016 and 2015, the Company recognized approximately $616,000 and $1,057,000 of contract revenue forservices and costs provided under the services agreement, respectively. The Company did not have revenue during the year ended December 31, 2014.In addition, the Company has a non-voting profit interest in the related party, which provides the Company with the potential to receive a portion ofthe future distributions of profits, if any. Investment funds affiliated with the Chairman of the Company’s board of directors have a controlling interest in, andthe Company’s CEO has a non-voting profit interest in, the related party.6. Shareholders’ EquityCommon Stock2014 Common Stock OfferingIn July 2014, the Company offered and sold an aggregate of 5,395,000 shares of common stock in an underwritten offering at a public offering priceof $10.50 per share, with gross proceeds of approximately $56.6 million. The CompanyF - 12La Jolla Pharmaceutical CompanyNotes to Consolidated Financial Statementsreceived net proceeds of approximately $53.1 million, less approximately $3.5 million in underwriting commissions, discounts and other issuance costs.2015 Common Stock OfferingIn September 2015, the Company offered and sold an aggregate of 2,932,500 shares of common stock in an underwritten offering at a public offeringprice of $38.00 per share, with gross proceeds of approximately $111.4 million. The Company received net proceeds of approximately $104.6 million, lessapproximately $6.8 million in underwriting commissions, discounts and other issuance costs.Preferred StockAs of December 31, 2016, the Company is authorized to issue 8,000,000 shares of preferred stock, with a par value of $0.0001 per share, in one ormore series, of which 11,000 are designated as Series C-12 Convertible Preferred Stock (Series C-12 Preferred) and 10,000 are designated as Series FConvertible Preferred Stock (Series F Preferred). During the year ended December 31, 2015, the Company issued 19,134 and 17,360 shares of common stockupon the conversion of Series C-12 Preferred and Series F Preferred, respectively. During the year ended December 31, 2014, the Company issued 5,341,670shares of common stock upon the conversion of Series C-12 Preferred and 129,105 shares of common stock upon the conversion of Series F Preferred. TheSeries C-12 Preferred is convertible into common stock at a rate of approximately 1,724 shares of common stock for each share of Series C-12 Preferred, andthe Series F Preferred is convertible into common stock at a rate of approximately 286 shares of common stock for each share of Series F Preferred.As of December 31, 2016 and 2015, there were 3,906 shares of Series C-12 Preferred and 2,737 shares of Series F Preferred issued and outstanding. Assuch, as of December 31, 2016 and 2015, the issued and outstanding Series C-12 Preferred and Series F Preferred were convertible into 6,735,378 and 782,032shares of common stock, respectively.The holders of preferred stock do not have voting rights, other than for general protective rights required by the California General Corporation Law.The Series C-12 Preferred and the Series F Preferred do not have dividends. The Series C-12 Preferred and the Series F Preferred have a liquidation preferencein an amount equal to $1,000 per share. As of December 31, 2016 and 2015, the aggregate liquidation preference was approximately $3,906,000 and$2,737,000 on the Series C-12 Preferred and Series F Preferred, respectively.Share-Based CompensationStock Options2013 Equity Incentive PlanIn September 2013, the Company adopted an equity compensation plan entitled the 2013 Equity Incentive Plan (2013 Equity Plan). The 2013Equity Plan is an omnibus equity compensation plan that permits the issuance of various types of equity-based compensation awards, including stockoptions, restricted stock awards, stock appreciation rights and restricted stock units, as well as cash awards, to employees, directors and eligible consultants ofthe Company. The 2013 Equity Plan has a ten-year term and permits the issuance of incentive stock options under Section 422 of the Internal Revenue Codeof 1986, as amended. The administrator under the plan has broad discretion to establish the terms of awards, including the size, term, exercise price andvesting conditions. Generally, grants to employees vest over four years, with 25% vesting on the one-year anniversary, and the remainder vesting eitherquarterly or monthly thereafter; grants to non-employee directors generally vest over one year on the one-year anniversary.The 2013 Equity Plan previously allowed for automatic annual increases to the number of shares of common stock authorized for issuance under the2013 Equity Plan on the first day of each year, with such increases based on 10% of the outstanding shares of the Company’s common stock as of the last dayof the previous year. On January 1, 2014, the total shares available for grant under the 2013 Equity Plan increased to 440,441. At the 2014 annual meeting ofshareholders, the Company's shareholders approved and adopted an amendment to the 2013 Equity Plan to increase the number of shares of common stockauthorized for issuance up to a total of 1,100,000 shares and eliminated the automatic annual increase on the first day of each year. At the 2015 annualmeeting of shareholders, the Company's shareholders approved and adopted an amendment to the 2013 Equity Plan to increase the number of shares ofcommon stock authorized for issuance up to a total of 3,100,000 shares. At the 2016 annual meeting of shareholders, the Company's shareholders approvedand adopted anF - 13La Jolla Pharmaceutical CompanyNotes to Consolidated Financial Statementsamendment to the 2013 Equity Plan to increase the number of shares of common stock authorized for issuance up to a total of 4,600,000 shares.As of December 31, 2016, there were 1,960,200 shares available for future grants under the 2013 Equity Plan.Share-Based Award ActivityThe Company’s 2013 Equity Plan stock option and restricted stock award activity for the years ended December 31, 2016, 2015 and 2014 wascomprised of the following: Outstanding Stock Options and 2013 Equity Plan Restricted Stock Awards SharesUnderlyingStock Options andRestricted StockAwards Weighted-AverageExercise Price perShare Weighted-AverageRemainingContractualTerm AggregateIntrinsicValueOutstanding at December 31, 201354,000 $6.00 Granted567,876 $9.88 Restricted stock awards vested(2,976) — Outstanding at December 31, 2014618,900 $9.54 Granted1,769,785 $25.89 Exercised(51,814) $10.81 Forfeited(18,186) $7.80 Outstanding at December 31, 20152,318,685 $22.01 Granted483,200 $17.83 Exercised(17,548) $8.52 Forfeited(156,875) $26.35 Outstanding at December 31, 20162,627,462 $21.07 8.39 years $4,307,756Vested and expected to vest at December 31, 20162,627,462 $21.07 8.39 years $4,307,756Exercisable at December 31, 20161,105,029 $20.45 7.85 years $2,740,900In April 2015, the Company made a stock option grant to the Company’s recently appointed Chief Financial Officer to purchase 60,000 shares ofcommon stock at an exercise price equal to the fair market value of the Company’s common stock on the grant date. This grant was awarded as an InducementGrant outside of the 2013 Equity Plan and is included in the table above. The stock option vests and becomes exercisable with respect to 25% of theunderlying shares on the first anniversary of the grant date, and then with respect to the remaining shares, on a quarterly basis over the next three years,subject to continued service during that time.As of December 31, 2016, the Company has reserved 4,527,662 shares of common stock for future issuance upon exercise of all outstanding stockoptions granted or to be granted under the 2013 Equity Plan, which excludes the 60,000 shares underlying the stock option discussed above that was issuedin April 2015.The weighted-average grant date fair values of the stock options granted was $15.33, $22.56, and $9.67 per underlying share for the years endedDecember 31, 2016, 2015 and 2014, respectively. As of December 31, 2016, $30,630,000 of total unrecognized share-based compensation expense related tonon-vested stock options remains and is expected to be recognized over a weighted-average period of approximately 2.8 years. During the year endedDecember 31, 2016, stock options to purchase 17,548 shares of common stock were exercised with an intrinsic value of $143,000. During the year endedDecember 31, 2015, stock options to purchase 51,814 shares of common stock were exercised with an intrinsic value of $928,000. No stock option exercisesoccurred during the year ended December 31, 2014.F - 14La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsThird Party Share-Based Compensation ExpenseThe Company initially estimates the fair value of stock options and warrants issued to non-employees, other than non-employee directors, on thegrant date using the Black-Scholes model. Thereafter, the Company re-measures the fair value using the Black-Scholes model as of each balance sheet date asthe stock options and warrants vest.In December 2014, the Company granted warrants to purchase 51,000 shares of common stock to two outside third parties at an exercise price equalto the fair market value of the stock on the date of each grant. One grant vests 25% on each anniversary date over four years. The other grant vested 100% onthe one-year anniversary of the grant. In January 2016, the Company granted a warrant to purchase 17,000 shares of common stock to an outside third party atan exercise price equal to the fair market value of the stock on the date of each grant. The grant vests 100% on the one-year anniversary of the grant. TheCompany recognized compensation expense for these warrant grants of approximately $217,000, $1,086,000 and $63,000 for the years ended December 31,2016, 2015 and 2014, respectively.In February 2015, the Company granted a stock option to purchase 60,000 shares of common stock to a consultant at an exercise price equal to thefair market value of the Company’s common stock on the grant date. This grant was made from the 2013 Equity Plan. The stock option vested with respect to25% of the underlying shares on the grant date with the remainder to vest quarterly over three years. The Company recognized third-party compensationexpense for this stock option grant of approximately $362,000 for the year ended December 31, 2015. In July 2015, this consultant became an employee ofthe Company.In August and November 2015, the Company granted stock options to purchase 50,000 shares of common stock to two consultants at exercise pricesequal to the fair market value of the Company’s common stock on the grant dates. These grants were made from the 2013 Equity Plan. The vesting of thesestock options was contingent on the achievement of a performance milestone by the end of 2016, at which time any unvested shares underlying the optionswill be canceled. The milestone was achieved in the fourth quarter of 2016 at a 75% achievement level, with 25% of the options canceling. The Companyrecognized compensation expense (benefit) for these stock option grants of approximately $(66,000) and $73,000 for the years ended December 31, 2016 and2015.In September 2016, the Company granted a stock option to purchase 35,000 shares of common stock to a consultant at an exercise price equal to thefair market value of the Company’s common stock on the grant date. This grant was made from the 2013 Equity Plan. The stock option will vest with respectto 25% of the underlying shares on the one-year anniversary of the grant, and then with respect to the remaining shares, on a monthly basis over the nextthree years, subject to continued service during that time. The Company recognized third-party compensation expense for this stock option grant ofapproximately $46,000 for the year ended December 31, 2016. In January 2017, this consultant became an employee of the Company.Restricted Stock Award ActivityRestricted stock awards (RSAs) are grants that entitle the holder to acquire shares of common stock for no cash consideration or at a fixed price,which is typically nominal. The Company accounts for RSAs as issued and outstanding common stock, even though: (a) shares covered by an RSA cannot besold, pledged, or otherwise disposed of until the award vests; and (b) any unvested shares may be reacquired by the Company for the original purchase pricefollowing the awardee's termination of service. The valuation of RSAs is based on the fair market value of the underlying shares on the grant date.In September 2013, the Company issued RSAs consisting of 1,327,048 shares to the Company’s Chief Executive Officer (CEO), 79,622 shares to adirector and an aggregate of 336,185 shares to three non-officer employees. The grants to the CEO, director and one of the employees were for thereplacement of canceled stock options and restricted stock units granted in April 2012, which was done in order to complete the capital restructuring thattook place in September 2013. These RSAs were granted outside of the 2013 Equity Plan, but are governed in all respects by the 2013 Equity Plan. TheseRSAs were granted with a combination of performance-based and time-based vesting components. As of December 31, 2016, all performance-based vestingconditions had been satisfied, but the time-based service requirements, which provided for vesting in 2017, subject to continuous service through the vestingand delivery date, had not yet been satisfied. In July 2015, the vesting conditions for 1,042,680 shares of unvested and outstanding RSA’s awarded to theCEO were amended to provide that vesting and delivery of the shares shall be deferred until March 15, 2017, subject to the CEO’s continued service with theCompany through such date. In December 2016, vesting and delivery was accelerated for 500,000 shares of the RSA's that had been deferred until March 15,2017. As of December 31, 2016, there were 542,680 shares remaining of unvested and outstanding RSA's awarded to the CEO, with vesting deferred on thisremaining balance until March 15, 2017.F - 15La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsOn January 25, 2014, the Company granted RSAs representing 2,976 shares of common stock with a grant date fair market value of $25,000 to aconsultant for services. The RSAs vested immediately and were issued from the 2013 Equity Plan.On March 31, 2014, RSAs representing 39,811 shares of common stock were canceled upon forfeiture. The remaining unrecognized share-basedcompensation expense for the canceled RSAs was expensed during the three months ended March 31, 2014. In addition, RSAs representing 7,318 shares ofcommon stock were canceled in exchange for the payment of employee income taxes during the three months ended September 30, 2014.In August 2015, the Company issued a fully vested RSA representing the right to acquire 4,000 shares of common stock with a grant date fair valueof approximately $92,000.The Company’s RSA activity for the years ended December 31, 2016, 2015 and 2014 was comprised of the following: Number of Shares Weighted-AverageGrant Date FairMarket ValueUnvested at December 31, 20131,746,853 $11.80Granted2,976 $8.40Vested(423,693) $9.18Forfeited(47,129) $4.41Unvested at December 31, 20141,279,007 $12.86Granted4,000 $23.12Vested(210,108) $12.41Unvested at December 31, 20151,072,899 $13.00Vested(530,219) $12.78Unvested at December 31, 2016542,680 $13.22As of December 31, 2016, approximately $409,000 of total unrecognized share-based compensation expense for general and administrativeactivities related to RSAs remains and is expected to be recognized in the first quarter of 2017.Stock Option ValuationThe fair value of each stock option award is estimated on the grant date using a Black-Scholes option pricing model (Black-Scholes model), whichuses the assumptions noted in the following table. Expected volatility is based on historical volatility of the Company’s common stock. In determining theexpected life of employee stock options, the Company uses the “simplified” method. The expected life assumptions for non-employees were based upon thecontractual term of the stock options. The risk-free interest rate is based on the U.S. Treasury yield for a period consistent with the expected term of the stockoptions in effect at the time of the grants. The dividend yield assumption is based on the expectation of no future dividend payments by the Company.The Company estimated the fair value of each stock option grant on the grant date using the Black-Scholes model with the following weighted-average assumptions: Year ended December 31, 2016 2015 2014Volatility143% 149% 186%Expected life (years)5.80 years 5.28 years 6.74 yearsRisk-free interest rate1.4% 1.5% 2.1%Dividend yield— — —F - 16La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsShare-Based Compensation ExpenseShare-based compensation expense recognized in the consolidated statements of operations for the years ended December 31, 2016, 2015 and 2014,is reduced by actual forfeitures of awards in the period that the forfeiture occurs.Total share-based compensation expense related to all share-based awards for the years ended December 31, 2016, 2015 and 2014 was comprised ofthe following (in thousands): Year Ended December 31, 2016 2015 2014Research and development: Stock options$5,599 $2,428 $258 Restricted stock30 1,600 1,009 Warrants28 56 2Research and development share-based compensation expense5,6574,0841,269General and administrative: Stock options6,539 3,693 894 Restricted stock2,161 4,265 6,856 Warrants189 1,030 61General and administrative share-based compensation expense8,8898,9887,811Total share-based compensation expense included in expenses$14,546$13,072$9,0807. Defined Contribution PlanThe Company has a defined contribution plan (401k Plan) covering substantially all of the Company’s employees. The 401k Plan was established toprovide retirement benefits for employees and is employee funded up to the elective annual deferral limits.Effective January 1, 2015, the 401k Plan was amended. As a result, all employees are eligible to participate with no minimum service requirement,the 401k Plan is no longer subject to the “safe harbor” provisions of IRS Notice 98-52 and the Company made matching contributions of $372,000 and$176,000 for the years December 31, 2016 and 2015, respectively.Prior to January 1, 2015, the 401k Plan was available for all employees who had completed one year of service with the Company. Followingguidance in IRS Notice 98-52 related to the “safe harbor” 401k Plan method, non-highly compensated employees received a non-elective contribution fromthe Company equal to 3% of their annual salaries, as defined in the Code. Such contributions vested immediately and were paid annually following each yearend. This “safe harbor” contribution by the Company was $28,000 for the year ended December 31, 2014.8. Income TaxesThe FASB Topic on Income Taxes prescribes a recognition threshold and measurement attribute criteria for the financial statement recognition andmeasurement of tax positions taken or expected to be taken in a tax return. For those benefits to be recognized, a tax position must be more-likely-than-not tobe sustained upon examination by taxing authorities. An uncertain income tax position will not be recognized if it has less than a 50% likelihood of beingsustained. There were no unrecognized tax benefits as of the date of adoption or as of December 31, 2016.The Company’s practice is to recognize interest and/or penalties related to income tax matters in income tax expense. The Company had no accrualfor interest or penalties on the Company’s balance sheets at December 31, 2016 or December 31, 2015, and has not recognized interest and/or penalties in thestatements of operations for the years ended December 31, 2016, 2015 and 2014.The Company is subject to taxation in the U.S. and various state jurisdictions. The Company’s tax years since inception and forward are subject toexamination by the U.S. and California tax authorities due to the carry forward of unutilized net operating losses and research and development credits.F - 17La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsThe Company has established a valuation allowance against its federal and state deferred tax assets due to the uncertainty surrounding therealization of such assets as evidenced by the cumulative losses from operations through December 31, 2016. Management periodically evaluates therecoverability of the deferred tax assets. At such time as it is determined that it is more likely than not that deferred assets are realizable, the valuationallowance will be reduced accordingly and recorded as a tax benefit.The Company has not completed a formal Section 382/383 analysis regarding the composition and limitation of net operating loss and research anddevelopment credit carryforwards. The Company does not presently plan to complete a formal Section 382/383 analysis; and until this analysis has beencompleted, the Company has removed the deferred tax assets for net operating losses and research and development credits generated through 2016 from itsdeferred tax asset schedule and has recorded a corresponding increase to its valuation allowance.As of December 31, 2016, the Company has estimated federal and California income tax net operating loss carryforwards of approximately$447,342,000 and $350,778,000, respectively. The difference between the federal and California tax loss carryforwards is primarily attributable to thecapitalization of research and development expenses for California income tax purposes. In addition, the Company has estimated federal and Californiaresearch and development tax credit carryforwards of approximately $19,450,000 and $11,734,000, respectively. The federal net operating loss, research taxcredit carryforwards and California net operating loss carryforwards will begin to expire in 2017, if not utilized. California research and development creditcarryforwards will carry forward indefinitely until utilized. The Company believes that, in May 2010 and February 2009, it experienced ownership changes attimes when its enterprise value was minimal. As a result of these ownership changes and the low enterprise values at such times, the Company’s federal andCalifornia net operating loss carryforwards and federal research and development credit carryforwards as of December 31, 2016 will likely be subject toannual limitations under IRC Section 382/383 and, more likely than not, will expire unused.Significant components of the Company’s deferred tax assets as of December 31, 2016, 2015 and 2014 are listed below (in thousands): December 31, 2016 2015 2014Deferred tax assets: Capitalized research and development and other$9,380 $33,894 $31,045Valuation allowance for deferred tax assets(9,380) (33,894) (31,045)Net deferred taxes$— $— $—Income taxes computed by applying the U.S. federal statutory rates to income from continuing operations before income taxes are reconciled to theprovision for income taxes set forth in the statement of operations as follows (in thousands): December 31, 2016 2015 2014Income tax benefit at statutory federal rate$(26,583) $(14,250) $(7,256)Research and development credits(1,240) 1,128 991Expired tax attributes(5) 31 (60)Change in valuation allowance25,091 12,042 6,322Other2,737 1,049 3Provision for income taxes$— $— $—9. Commitments and ContingenciesLeasesIn February 2015, the Company entered into a 32-month lease agreement, as a sublessee, for 18,599 square feet of office space to be used as theCompany’s corporate headquarters. The lease term is through October 2017. The Company also leases a total of 3,713 square feet of office space with a leaseterm through March 2018.F - 18La Jolla Pharmaceutical CompanyNotes to Consolidated Financial StatementsIn January 2016, the Company entered into a 20-month lease agreement, as a sublessee, for 24,105 square feet of lab space. The lease term is fromJanuary 2016 through August 2017, and the total lease payments through the end of the lease will be approximately $726,000. The Company also leases atotal of 4,047 square feet of lab space with a lease term through March 2017.Annual future minimum payments under operating leases as of December 31, 2016 were as follows (in thousands): OperatingLeases SubleaseIncome Net OperatingLeases2017$1,040 $(74) $966201836 (19) 17Total minimum lease payments$1,076 $(93) $983On December 29, 2016, the Company entered into an agreement with BMR-Axiom LP to lease office and laboratory space in the building located at4550 Towne Centre Court, San Diego, California (the “Lease”) for a period of ten years commencing on or about November 1, 2017.The Lease provides an option to extend the Lease for an additional five years at the end of the initial term, as well as an option to terminate theLease on or before March 31, 2017, subject to certain contingencies. Due to the existence of a termination right, prior to the commencement of rent paymentsunder the Lease, potential rent payments have not been included in the lease commitment table set forth above. Following the lapse of the termination right,these commitments will be reflected in the lease commitment table, to the extent the Lease is not terminated. The Company will be providing a standby letterof credit for $303,000 in lieu of a security deposit. This amount will increase to $909,000 on March 31, 2017, then decrease to $606,000 after year two of thelease and decrease to $303,000 after year five of the lease term. The annual rent under the Lease is initially $3,636,000 per annum, subject to escalationduring the term. In addition to rent, the Lease requires the Company to pay certain taxes, insurance, and operating costs relating to the leased premises. TheLease contains customary default provisions, representations, warranties and covenants.Rent expense was $1,093,000, $699,000 and $176,000 for the years ended December 31, 2016, 2015 and 2014, respectively.Licensing AgreementsIn the normal course of business, the Company enters into licensing agreements under which the Company commits to certain annual maintenancepayments. Annual future minimum licensing payments under the Company's agreements as of December 31, 2016 are as follows (in thousands): MinimumPayments2017$89201899201957202063202127Thereafter120Total minimum annual maintenance fee payments$455F - 19La Jolla Pharmaceutical CompanyNotes to Consolidated Financial Statements10. Quarterly Financial Information (unaudited)The following is a summary of the quarterly results of operations for the years ended December 31, 2016 and 2015 (in thousands, except per shareamounts): FirstQuarter SecondQuarter ThirdQuarter FourthQuarter2016 Total revenue$234 $253 $44 $85Loss from operations$(16,534) $(15,617) $(21,297) $(24,924)Net loss$(16,481) $(15,566) $(21,251) $(24,887)Basic and diluted net loss per share$(0.96) $(0.90) $(1.23) $(1.44)Shares used in computing basic and diluted net loss per share17,210 17,211 17,211 17,2802015 Total revenue$— $— $647 $410Loss from operations$(8,966) $(10,658) $(10,487) $(11,858)Net loss$(8,955) $(10,650) $(10,474) $(11,833)Basic and diluted net loss per share$(0.59) $(0.70) $(0.70) $(0.69)Shares used in computing basic and diluted net loss per share15,242 15,251 14,899 17,200F - 20​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ LEASE ​ by and between ​ BMR-AXIOM LP, ​ a Delaware limited partnership ​ and ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ Table of Contents ​ 1. Lease of Premises .................................................................................................................. 1 ​ 2. Basic Lease Provisions .......................................................................................................... 2 ​ 3. Term ...................................................................................................................................... 4 ​ 4. Possession and Commencement Date. .................................................................................. 7 ​ 5. Condition of Premises ......................................................................................................... 10 ​ 6. Rentable Area ...................................................................................................................... 11 ​ 7. Rent ..................................................................................................................................... 12 ​ 8. Rent Adjustments ................................................................................................................ 12 ​ 9. Operating Expenses ............................................................................................................. 12 ​ 10. Taxes on Tenant’s Property................................................................................................. 19 ​ 11. Security Deposit .................................................................................................................. 20 ​ 12. Use ....................................................................................................................................... 23 ​ 13. Rules and Regulations, CC&Rs, Parking Facilities and Common Area .............................. 25 ​ 14. Project Control by Landlord ................................................................................................ 26 ​ 15. Quiet Enjoyment .................................................................................................................. 27 ​ 16. Utilities and Services ........................................................................................................... 27 ​ 17. Alterations ........................................................................................................................... 31 ​ 18. Repairs and Maintenance .................................................................................................... 34 ​ 19. Liens .................................................................................................................................... 36 ​ 20. Estoppel Certificate ............................................................................................................. 37 ​ 21. Hazardous Materials ............................................................................................................ 37 ​ 22. Odors and Exhaust .............................................................................................................. 40 ​ 23. Insurance; Waiver of Subrogation ....................................................................................... 41 ​ 24. Damage or Destruction ........................................................................................................ 45 ​ 25. Eminent Domain .................................................................................................................. 47 ​ 26. Surrender ............................................................................................................................. 48 ​ 27. Holding Over ....................................................................................................................... 49 ​ 28. Indemnification and Exculpation ........................................................................................ 50 ​ 29. Assignment or Subletting .................................................................................................... 51 ​ 30. Subordination and Attornment ............................................................................................ 55 ​ 31. Defaults and Remedies ........................................................................................................ 56 ​ i ​ ​ ii ​ 32. Bankruptcy ............................................................................................................................ 61 ​ 33. Brokers .................................................................................................................................. 61 ​ 34. Definition of Landlord .......................................................................................................... 62 ​ 35. Limitation of Landlord’s Liability ........................................................................................ 62 ​ 36. Joint and Several Obligations ............................................................................................... 63 ​ 37. Representations ..................................................................................................................... 63 ​ 38. Confidentiality ...................................................................................................................... 64 ​ 39. Notices .................................................................................................................................. 64 ​ 40. Miscellaneous ....................................................................................................................... 64 ​ 41. [Intentionally omitted] .......................................................................................................... 67 ​ 42. Option to Extend Term ......................................................................................................... 67 ​ ​ ​ LEASE ​ THIS LEASE (this “Lease”) is entered into as of this day of December, 2016 ​ (the “Execution Date”), by and between BMR-AXIOM LP, a Delaware limited partnership ​ (“Landlord”), and LA JOLLA PHARMACEUTICAL COMPANY, a California corporation ​ (“Tenant”). ​ RECITALS ​ ​ A. WHEREAS, Landlord owns certain real property (the “Property”) and the ​ improvements on the Property located at 4535, 4545 and 4550 Towne Centre Court, San Diego, ​ California, known as “AXIOM”; and ​ ​ B. WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from ​ Landlord, certain premises (the “Premises”) in the Building located at 4550 Towne Centre Court, ​ San Diego, California (the “Building”) pursuant to the terms and conditions of this Lease, as ​ detailed below. ​ ​ AGREEMENT ​ ​ NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises ​ contained herein and for other good and valuable consideration, the receipt and sufficiency of ​ which are hereby acknowledged, and intending to be legally bound, agree as follows: ​ ​ 1. Lease of Premises. ​ ​ 1.1 Effective on the Term Commencement Date (as defined below), Landlord hereby ​ leases to Tenant, and Tenant hereby leases from Landlord, the Premises, as shown on Exhibit A ​ attached hereto, including exclusive shafts, cable runs and mechanical spaces, for use by Tenant ​ in accordance with the Permitted Use (as defined below) and no other uses. The Property and all ​landscaping, parking facilities, private drives and other improvements and appurtenances related ​ thereto, including the Building and other buildings located on the Property, are hereinafter ​ collectively referred to as the “Project.” All portions of the Project that are for the non-exclusive ​ use of tenants of the Project generally, including driveways, sidewalks, parking areas, ​ landscaped areas, public restrooms, public lobbies and the Amenities Center (as defined below), ​ are hereinafter referred to as “Common Area.” ​ ​ 1.2. As a component of the Landlord Work (as defined below), Landlord shall develop ​ an amenities facility serving the Project (the “Amenities Center”), which shall include certain ​ amenities for the Project, which amenities shall include a café and fitness center, along with ​ other amenities selected by Landlord (such as a conference area). Any such amenities shall be ​ referred to herein as the “Amenities Center Services.” ​ ​ 2 ​ 2. Basic Lease Provisions. For convenience of the parties, certain basic provisions of this ​ Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and ​ conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. ​ ​ 2.1. This Lease shall take effect upon the Execution Date and, except as specifically ​ otherwise provided within this Lease, each of the provisions hereof shall be binding upon and ​ inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all ​ parties hereto. ​ ​ 2.2. In the definitions below, each current Rentable Area (as defined below) is ​ expressed in square feet. Rentable Area and “Tenant’s Pro Rata Shares” are all subject to ​ adjustment as provided in this Lease. ​ ​ ​ Definition or Provision ​ Means the Following ​ (As of the Execution Date) ​ Approximate Rentable Area of Premises1 83,008 square feet ​ Approximate Rentable Area of Building 83,008 square feet ​ Approximate Rentable Area of Project 182,866 square feet ​ Tenant’s Pro Rata Share of Building 100% ​ Tenant’s Pro Rata Share of Project 45.39% ​ ​ 2.3. Initial monthly and annual installments of Base Rent for the Premises (“Base ​ Rent”) as of the Term Commencement Date, subject to adjustment under this Lease: ​ ​ ​ ​ Dates ​ Square Feet ​ of Rentable ​ Area ​ ​ Base Rent per Square ​ Foot of Rentable Area ​ ​ Monthly ​ Base Rent ​ ​ Annual Base ​ Rent ​ Months 1 - 8 83,008 $0.00 monthly N/A N/A ​Months 9 - 12 83,008 $3.65 monthly $302,979.20 $3,635,750.40 ​ ​ 2.4. Estimated Term Commencement Date: November 1, 2017 ​ ​ 2.5. Estimated Term Expiration Date: October 31, 2027 ​ ​ ​ ​ 1 The Rentable Area of the Premises includes an equitable allocation of the Rentable Area of the Amenities Center. ​ ​ 3 ​ 2.6. Security Deposit: $908,937.60 ​ ​ 2.7. Permitted Use: Office and laboratory use and ancillary uses in support thereof, all ​ in conformity with all federal, state, municipal and local laws, codes, ordinances, rules and ​ regulations of Governmental Authorities (as defined below), committees, associations, or other ​ regulatory committees, agencies or governing bodies having jurisdiction over the Premises, the ​ Building, the Property, the Project, Landlord or Tenant, including both statutory and common ​ law and hazardous waste rules and regulations (“Applicable Laws”) ​ ​ 2.8. Address for Rent Payment: ​ ​ BMR-Axiom LP ​ Attention Entity 694 ​ P.O. Box 511387 ​ Los Angeles, California 90051-7942 ​ ​ 2.9. Address for Notices to Landlord: ​ ​ BMR-Axiom LP ​ 17190 Bernardo Center Drive ​ San Diego, California 92128 ​ Attn: Legal Department ​ ​ 2.10. Address for Notices to Tenant: ​ ​ La Jolla Pharmaceutical Company ​ 10182 Telesis Court, Suite 600 ​ San Diego, California 92121 ​ Attn: Legal Department ​ slee@ljpc.com ​ ​ 2.11. Address for Invoices to Tenant: ​ ​ La Jolla Pharmaceutical Company ​ 10182 Telesis Court, Suite 600 ​ San Diego, California 92121 ​ Attn: Accounts Payable ​ E-Mail: ap@ljpc.com ​ ​ 2.12. The following Exhibits are attached hereto and incorporated herein by reference: ​ ​ Exhibit A Premises ​ Exhibit B Work Letter ​ Exhibit B-1 Tenant Work Insurance Schedule ​ Exhibit C Acknowledgement of Term Commencement Date and Term ​ Expiration Date ​ Exhibit D Landlord Work ​ ​ 4 ​ Exhibit E Form of Letter of Credit ​ Exhibit F Rules and Regulations ​ Exhibit G Form of Additional TI Allowance Acceptance Letter ​ Exhibit H Tenant’s Personal Property ​ Exhibit I Form of Estoppel Certificate ​ Exhibit J [Intentionally Omitted] ​ Exhibit K Rooftop License ​ Exhibit L TI Allowance and Commission Fee Schedule ​ Exhibit M Form Subordination, Non-Disturbance and Attornment Agreement ​ ​ 3. Term. The actual term of this Lease (as the same may be extended pursuant to Article 42 ​ hereof, and as the same may be earlier terminated in accordance with this Lease, the “Term”) ​ shall commence on the actual Term Commencement Date (as defined in Article 4) and end on ​ the date (the “Term Expiration Date”) that is one hundred twenty (120) months after the actual ​ Term Commencement Date, subject to extension or earlier termination of this Lease as provided ​ herein. TENANT HEREBY WAIVES THE REQUIREMENTS OF SECTION 1933 OF THE ​ CALIFORNIA CIVIL CODE, AS THE SAME MAY BE AMENDED FROM TIME TO TIME. ​ ​ 3.1 Clinical Trial Termination Option. As of the Execution Date, Tenant is ​ conducting a Phase 3 clinical trial for LJPC-501 for the treatment of catecholamine-resistant ​ hypotension (the “Clinical Trial”). In the event that the Clinical Trial fails to meet one or more ​ of the primary or secondary endpoints (such endpoints being referred to herein collectively as the ​ “Clinical Endpoints”) on or before March 31, 2017 (the “Clinical Trial Termination Outside ​ Date), then Tenant willhave a one-time option to terminate this Lease (the “Clinical Trial ​ Termination Option”), subject to the terms, conditions and provisions of this Section. In the ​ event that the requirements of the foregoing sentence have not occurred on or before the Clinical ​ Trial Termination Outside Date, the Clinical Trial Termination Option shall automatically ​ become void and of no further force or effect. The Clinical Trial Termination Outside Date shall ​ not be extended for any reason whatsoever. ​ ​ 3.1.1 The Clinical Trial Termination Option is conditional upon Tenant ​ delivering the following items to Landlord on or before the Clinical Trial Termination Outside ​ Date: (a) written notice of Tenant’s election to exercise the Clinical Trial Termination Option ​ (the “Clinical Trial Termination Notice”) and (b) the Clinical Trial Termination Deliverables (as ​ defined below). Tenant shall not be deemed to have exercised the Clinical Trial Termination ​ Option unless and until Tenant has delivered to Landlord both the Clinical Trial Termination ​ Notice and the Clinical Trial Termination Deliverables. Time shall be of the essence as to ​ Tenant’s exercise of the Clinical Trial Termination Option. Tenant acknowledges that it would ​ be inequitable to require Landlord to accept any exercise of the Clinical Trial Termination ​ Option after the Clinical Trial Termination Outside Date. Any attempted exercise of the Clinical ​ Trial Termination Option after the Clinical Trial Termination Outside Date shall be void and of ​ no force or effect. ​ ​ 3.1.2 For purposes of this Lease,the “Clinical Trial Termination Deliverables” ​ means (a) an amount equal to the Clinical Trial Termination Fee (as defined below), and (b) a ​ summary of the Clinical Trial results certified by an officer of Tenant as true and correct and a ​ ​ 5 ​ statement from such officer certifying that the Clinical Trial failed to achieve one or more of the ​ Clinical Endpoints. Landlord acknowledges that the proof provided in (b) above may contain ​ confidential and proprietary information, and Landlord agrees that all such information shall be ​ kept strictly confidential, subject to the terms of Article 38. The “Clinical Trial Termination ​ Fee” means an amount equal to (i) Five Hundred Thousand Dollars ($500,000) if the Clinical ​ Trial Termination Option is exercised in accordance with this Section on or before January 31, ​ 2017, (ii) Seven Hundred Thousand Dollars ($700,000) if the Clinical Trial Termination Option ​ is exercised in accordance with this Section between February 1, 2017 and February 28, 2017, ​ and (iii) Nine Hundred Thousand Dollars ($900,000) if the Clinical Trial Termination Option is ​ exercised in accordance with this Section between March 1, 2017 and the Clinical Trial ​ Termination Outside Date. ​ ​ 3.1.3 If Tenant exercises the Clinical Trial Termination Option in accordance ​ with this Section on or before the Clinical Trial Termination Outside Date, then this Lease shall ​ terminate on the date which is three (3) business days after the date Tenant so exercises the ​ Clinical Trial Termination Option (such date, the “Clinical Trial Termination Date”), and this ​ Lease shall thereafter be of no further force or effect, except for those provisions that, by their ​ express terms, survive the expiration or earlier termination of this Lease. Tenant shall surrender ​the Premises to Landlord on the Clinical Trial Termination Date in accordance with all of the ​ terms and conditions of this Lease. If Tenant does not so surrender the Premises in accordance ​ with all of the terms and conditions of this Lease on or before the Clinical Trial Termination ​ Date, then Tenant, pursuant to Section 27.2, shall become a tenant at sufferance with respect to ​ the Premises until the actual date that Tenant surrenders the Premises to Landlord in accordance ​ with the terms and conditions of this Lease and rent for the Premises shall commence to accrue ​ on a per diem basis as of the Clinical Trial Termination Date at the rate set forth in Section 27.2, ​ calculated as if the rent for the prior month were Three Hundred Two Thousand Nine Hundred ​ Seventy-Nine and 20/100 Dollars ($302,979.20). ​ ​ 3.1.4 Notwithstanding anything in this Section to the contrary, Tenant shall not ​ be permitted to exercise the Clinical Trial Termination Option during such period of time that ​ Tenant is in Default under any provision of this Lease. Any attempted exercise of the Clinical ​ Trial Termination Option during a period of time in which Tenant is so in Default shall be void ​ and of no force or effect. ​ ​ 3.1.5 Landlord will keep all non-public information disclosed to Landlord in ​ connection with the Clinical Trial and the Clinical Endpoints confidential in accordance with ​ Article 38 of this Lease, and will not disclose such information, except in the circumstances ​ permitted under Article 38. ​ ​ 3.2 AcquisitionTermination Option. In the event that (a) substantially all of Tenant’s ​ assets or stock are acquired by a third-party company in an arm’s length transaction for a ​ legitimate business purpose, and (b) such acquiring company determines that the Premises are no ​ longer needed for business operations, Tenant shall have the one-time option to terminate this ​ Lease (the “Acquisition Termination Option”) effective as of the date that is any date (such date, ​ the “Acquisition Termination Date”) selected by Tenant that is after the date that is ninety-six ​ ​ 6 ​ (96) months after the Term Commencement Date, subject to the terms, conditions and provisions ​ of this Section. ​ ​ 3.2.1 The Acquisition Termination Option is conditional upon Tenant delivering ​ the following items to Landlord on or before the date that is twelve (12) months prior to the ​ Acquisition Termination Date: (a) written notice of Tenant’s election to exercise the Acquisition ​ Termination Option (the “Acquisition Termination Notice”) and (b) the Acquisition Termination ​ Deliverables (as defined below); provided, however, that the Acquisition Termination Fee (as ​ defined below) shall not be due and payable until the Acquisition Termination Date. Tenant ​ shall not be deemed to have exercised the Acquisition Termination Option unless and until ​ Tenant has delivered to Landlord both the Acquisition Termination Notice and the Acquisition ​ Termination Deliverables; provided, however, that the Acquisition Termination Fee shall not be ​ due and payable until the Acquisition Termination Date. Notwithstanding anything contained ​ herein, the Acquisition Termination Notice will be effective upon delivery of the Acquisition ​ Termination Notice and the Acquisition Termination Deliverables (other than the Acquisition ​ Termination Fee), irrespective of the fact that the Acquisition Termination Fee is payable at a ​ later date. Time shall be of the essence as to Tenant’s exercise of the Acquisition Termination ​ Option. ​ ​ 3.2.2 For purposes of this Lease, the “Acquisition TerminationDeliverables” ​ means (a) an amount equal to the Acquisition Termination Fee (as defined below), (b) proof that ​ substantially all of the assets or stock of Tenant was acquired by a third-party company in an ​ arm’s length transaction for a legitimate business purpose and (c) a statement from an officer of ​ the acquiring company stating that the Premises are no longer needed for business operations. ​ The “Acquisition Termination Fee” means an amount equal to the sum of (y) Two Million Four ​ Hundred Twenty-Three Thousand Eight Hundred Thirty-Three and 60/100 Dollars ​ ($2,423,833.60), plus (z) the unamortized amounts (as of the Acquisition Termination Date) of ​ (i) the TI Allowance (as defined below), and (ii) all leasing commissions paid by Landlord in ​ connection with this Lease (the “Commission Fee”) (which amounts in Subsection 3.2.2(z)(i) ​ and (ii) shall be calculated by amortizing the same at eight percent (8%) per annum commencing ​ on the Term Commencement Date and ending on the Term Expiration Date) as set forth on ​ Exhibit L attached hereto. ​ ​ 3.2.3 If Tenant exercises the Acquisition Termination Option in accordance ​ with this Section on or before the Acquisition Termination Outside Date, then this Lease shall ​ terminate on the Acquisition Termination Date, and this Lease shall thereafter be of no further ​ force or effect, except for those provisions that, by their express terms, survive the expiration or ​ earlier termination of this Lease. Tenant shall surrender thePremises to Landlord on or before ​ the Acquisition Termination Date in accordance with all of the terms and conditions of this ​ Lease. If Tenant does not so surrender the Premises in accordance with all of the terms and ​ conditions of this Lease on or before the Acquisition Termination Date, then Tenant, pursuant to ​ Article 27, shall become a tenant at sufferance with respect to the Premises until the actual date ​ that Tenant surrenders the Premises to Landlord in accordance with the terms and conditions of ​ this Lease. ​ ​ 7 ​ 3.2.4 Notwithstanding anything in this Section to the contrary, Tenant shall not ​ be permitted to exercise the Acquisition Termination Option during such period of time that ​ Tenant is in Default under any provision of this Lease and, at Landlord’s option, any exercise of ​ the Acquisition Termination Option shall be null and void in the event that after Tenant’s ​ exercise of the Acquisition Termination Option, but prior to the Acquisition Termination Date, ​ Tenant is in Default under any provision of this Lease. Any attempted exercise of the ​ Acquisition Termination Option during a period of time in which Tenant is so in Default shall be ​ void and of no force or effect. ​ ​ 4. Possession and Commencement Date. ​ ​ 4.1. Landlord shall, at Landlord’s sole cost and expense, complete the work listed on ​ Exhibit D attached hereto (the “Landlord Work”). Promptly following the Execution Date, ​ Landlord shall commence the items of the Landlord Work identified on Exhibit D as the “Pre- ​ Delivery Landlord Work” and shall diligently prosecute the Pre-Delivery Landlord Work to ​ completion. Upon completion of the Pre-Delivery Landlord Work (a) Landlord shall deliver the ​ Premises to Tenant for Tenant’s construction of the Tenant Improvements (as defined below), ​ and (b) Tenant shall have full access to the Premises to construct the Tenant Improvements ​ (subject to the terms, conditions and provisions of this Lease and the Work Letter). Landlord ​ and Tenant will cooperate with one another asrequired to allow (i) Landlord to complete the ​ Post-Delivery Landlord Work (as defined in Exhibit D) in accordance with Landlord’s plans and ​ schedule for the completion of such work (and Tenant will ensure that Tenant’s construction of ​ the Tenant Improvements does not interfere with the completion of the Post-Delivery Landlord ​ Work) and (ii) Tenant to construct the Tenant Improvements (and Landlord will ensure that ​ Landlord’s construction of the Post-Delivery Landlord Work does not interfere with the ​ completion of the Tenant Improvements). In the event of a conflict in accordance with the ​ foregoing which cannot be resolved through agreement of the parties, Landlord’s completion of ​ the Post-Delivery Landlord Work will have priority. ​ ​ 4.2. The “Term Commencement Date” shall be the earlier of (a) the Estimated Term ​ Commencement Date and (b) the first day Tenant commences business operations in any portion ​ of the Premises; provided, however, if Landlord fails to complete the Pre-Delivery Landlord ​ Work by February 28, 2017 (the “Pre-Delivery Landlord Work Target Date”) (which Pre- ​ Delivery Landlord Work Target Date will be extended on a day-for-day basis by the number of ​ days of delay caused by Force Majeure or delays caused by Tenant or any Tenant Party (as ​ defined in Section 21.1)), then the Estimated Term Commencement Date shall be extended on a ​ day-for-day basis for each day thereafter that the Pre-Delivery Landlord Work is notcomplete. ​ If Landlord fails to complete the Pre-Delivery Landlord Work by May 1, 2017 (the “Pre- ​ Delivery Landlord Work Outside Date”) (which Pre-Delivery Landlord Work Outside Date will ​ be extended on a day-for-day basis by the number of days of delay caused by Force Majeure or ​ delays caused by Tenant or any Tenant Party (as defined in Section 21.1)), then Tenant shall be ​ entitled to receive one (1) day of Rent abatement for each day thereafter that the Pre-Delivery ​ Landlord Work is not complete, and such abatement shall be applied toward Tenant’s first ​ required payment(s) of Rent during the Term. Tenant shall execute and deliver to Landlord ​ written acknowledgment of the actual Term Commencement Date and the Term Expiration Date ​ within ten (10) days after Tenant takes occupancy of the Premises, in the form attached as ​ ​ 8 ​ Exhibit C hereto. Failure to execute and deliver such acknowledgment, however, shall not affect ​ the Term Commencement Date or Landlord’s or Tenant’s liability hereunder. Failure by Tenant ​ to obtain validation by any medical review board or other similar governmental licensing of the ​ Premises required for the Permitted Use by Tenant shall not serve to extend the Term ​ Commencement Date. The term “Substantially Complete” or “Substantial Completion” means ​ that the Tenant Improvements are substantially complete in accordance with the Approved Plans ​ (as defined in the Work Letter), except for minor punch list items. ​ ​ 4.3. Tenant shall cause the Tenant Improvements to be constructed in the Premises ​ pursuant to the Work Letter attached hereto as Exhibit B (the “Work Letter”) at a cost to ​ Landlord not to exceed (i) Twelve Million Four Hundred Fifty-One Thousand Two Hundred and ​ 00/100 Dollars ($12,451,200) (the “Base TI Allowance”) plus (ii) if properly requested by ​ Tenant pursuant to this Section, One Million Two Hundred Forty-Five Thousand One Hundred ​ Twenty and 00/100 Dollars ($1,245,120) (the "Additional TI Allowance"), for a total of Thirteen ​ Million Six Hundred Ninety-Six Thousand Three Hundred Twenty Dollars ($13,696,320). The ​ Base TI Allowance, together with the Additional TI Allowance (if properly requested by Tenant ​ pursuant to this Article), shall be referred to herein as the "TI Allowance. The TI Allowance ​ may be applied to the costs of(a) construction, (b) project review by Landlord (which fee shall ​ equal one-half of one percent (0.5%) of the TI Allowance), (c) commissioning of mechanical, ​ electrical and plumbing systems by a licensed, qualified commissioning agent hired by Tenant, ​ and reasonably approved by Landlord, (d) space planning, architect, engineering and other ​ related services performed by third parties unaffiliated with Tenant and up to three and one-half ​ percent (3.5%) of the TI Allowance may be used for the cost of a third party project management ​ consultant retained by Tenant, (e) building permits and other taxes, fees, charges and levies by ​ Governmental Authorities (as defined below) for permits or for inspections of the Tenant ​ Improvements, and (f) costs and expenses for labor, material, equipment and fixtures. In no ​ event shall the TI Allowance be used for (v) the cost of work that is consistent with the ​ Approved Plans (as defined in the Work Letter) or otherwise approved in writing by Landlord, ​ (w) payments to Tenant or any affiliates of Tenant, (x) the purchase of any furniture, personal ​ property or other non-building system equipment (provided, however, that Tenant shall be ​ permitted to apply up to One Million Two Hundred Forty-Five Thousand One Hundred Twenty ​ and 00/100 Dollars ($1,245,120) of the TI Allowance toward Tenant’s cost to move into the ​ Premises, to fabricate and install Tenant’s Signage, and to purchase furniture, fixtures and ​ equipment,telecommunications and data cabling, security and audio visual systems to be used in ​ the Premises), (y) costs resulting from any default by Tenant of its obligations under this Lease ​ or (z) costs that are recoverable by Tenant from a third party (e.g., insurers, warrantors, or ​ tortfeasors). Tenant will be permitted to reuse any of the existing fifteen (15) fume hoods ​ currently being stored on the ground floor of the Building; provided that such fume hoods are ​ accepted by Tenant in their “as is” condition and Landlord makes no representation or warranty ​ as to the condition of such fume hoods or their fitness for Tenant’s intended use. Tenant will ​ repair and maintain the fume hoods which Tenant elects to use throughout the Term in ​ accordance with industry standard repair and maintenance standards, provided that Tenant will ​ have the right to either replace or remove any fume hoods that Tenant has elected to use which ​ reach the end of their serviceable life during the Term of the Lease. ​ ​ 9 ​ 4.4. Base Rent shall be increased to include the amount of the Additional TI ​ Allowance disbursed by Landlord in accordance with this Lease amortized over the initial Term ​ at a rate of eight percent (8%) annually. Tenant shall have until the date that is six (6) months ​ after the Term Commencement Date (the “TI Deadline”), to expend the unused portion of the TI ​ Allowance, after which date Landlord’s obligation to fund such costs shall expire. The amount ​ by which Base Rent shall be increased shall be determined (and Base Rent shall be increased ​ accordingly) as of the Term Commencement Date and, if such determination does not reflect use ​ by Tenant of all of the Additional TI Allowance, shall be determined again as of the TI Deadline, ​ with Tenant paying (on the next succeeding day that Base Rent is due under this Lease (the "TI ​ True-Up Date")) any underpayment of the further adjusted Base Rent for the period beginning on ​ the Term Commencement Date and ending on the TI True-Up Date. ​ ​ 4.5. Landlord shall not be obligated to expend any portion of the Additional TI ​ Allowance until Landlord shall have received from Tenant a letter in the form attached as ​ Exhibit G hereto executed by an authorized officer of Tenant. In no event shall any unused TI ​ Allowance entitle Tenant to a credit against Rent payable under this Lease. Tenant shall deliver ​ to Landlord (a) a certificate of occupancy (or its substantial equivalent) for the Premises suitable ​ forthe Permitted Use and (b) a Certificate of Substantial Completion in the form of the ​ American Institute of Architects document G704, executed by the project architect and the ​ general contractor. ​ ​ 4.6. Prior to entering upon the Premises, Tenant shall furnish to Landlord evidence ​ satisfactory to Landlord that insurance coverages required of Tenant under the provisions of ​ Article 23 are in effect, and such entry shall be subject to all the terms and conditions of this ​ Lease other than the payment of Base Rent or Tenant’s Adjusted Share of Operating Expenses ​ (as defined below). ​ ​ 4.7. Landlord and Tenant shall mutually agree upon the selection of the engineers, ​ general contractor and major subcontractors; provided that Tenant will have the right to select ​ the general contractor pursuant to a competitive bid process using general contractors mutually ​ approved by Landlord and Tenant. Tenant shall enter into a design contract with McFarlane ​ Architects to act as the architect for the Tenant Improvements (and shall provide a copy of such ​ design contract to Landlord) within two (2) business days after the Execution Date. Landlord ​ may refuse to approve any architects, consultants, contractors, subcontractors or material ​ suppliers that Landlord reasonably believes could cause labor disharmony or may not have ​ sufficient experience, in Landlord’s reasonable opinion, to perform work in an occupied Class ​ “A” laboratory research building and in labareas. ​ ​ 4.8. Tenant shall pay all utility charges, together with any fees, surcharges and taxes ​ thereon for the period beginning on the date that Landlord delivers the Premises to Tenant for ​ Tenant’s construction of the Tenant Improvements in accordance with Section 4.1; provided, ​ however, that Tenant shall not be responsible for any utility charges attributable to the Post- ​ Delivery Landlord Work. ​ ​ 4.9. Notwithstanding anything to the contrary in this Lease or in the Work Letter, ​ Landlord shall have no obligation to fund any portion of the TI Allowance prior to the date (the ​ “TI Funding Date”) upon which the Clinical Trial Termination Option is waived by Tenant in ​ ​ 10 ​ writing or becomes void or lapses due to time. Prior to the TI Funding Date, Tenant will pay all ​ costs associated with the Tenant Improvements as and when such amounts become due, and will ​ ensure that all such costs are paid timely and in a manner which eliminates any risk of a lien ​ being filed against the Building; provided that Tenant will not be permitted to commence any ​ demolition or construction in the Premises prior to the date upon which the Clinical Trial ​ Termination Option is waived by Tenant in writing or becomes void or lapses due to time. In the ​ event that Tenant exercises the Clinical Trial Termination Option, Landlord shall have no ​ obligation to fund any portion of the TI Allowance or to otherwise reimburse Tenant for any ​ costs incurred by Tenant in connection with the Tenant Improvements, this Lease or the ​ Premises. In the event that Tenant does not exercise the Clinical Trial Termination Option and ​ the Clinical Trial Termination Option lapses or becomes void, all costs incurred by Tenant in ​ connection with the Tenant Improvements shall (to the extent such costs would otherwise be ​ chargeable against the TI Allowance pursuant to this Lease) be subject to reimbursement from ​ the TI Allowance in accordance with the terms of the Work Letter. ​ ​ 5. Condition of Premises. Except as provided below, Tenant acknowledges that neither ​ Landlord nor any agent of Landlord has made any representation or warranty with respect to the ​ conditionof the Premises, the Building or the Project, or with respect to the suitability of the ​ Premises, the Building or the Project for the conduct of Tenant’s business. Except as provided ​ below, Tenant acknowledges that (a) it is fully familiar with the condition of the Premises and ​ agrees to take the same in its condition “as is” as of the date that Landlord delivers the Premises ​ to Tenant for Tenant’s construction of the Tenant Improvements in accordance with Section 4.1, ​ and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the Premises for ​ Tenant’s occupancy or to pay for or construct any improvements to the Premises, except with ​ respect to the performance, at Landlord’s sole cost and expense, of the Landlord Work and ​ payment of the Base TI Allowance and, if properly requested by Tenant pursuant to the terms of ​ the Lease, the Additional TI Allowance. Notwithstanding anything to the contrary in this Lease, ​ Landlord shall deliver the Premises to Tenant with (y) the Pre-Delivery Landlord Work and (z) ​ the existing heating, ventilating and air-conditioning, electrical, plumbing and fire/life safety ​ systems serving the Building core (but not the distribution of such systems throughout the ​ Premises, which will be performed as part of the Tenant Improvements), the existing galvanized ​ supply air and exhaust air duct risers, the existing roof structure, roof membrane, Building ​ elevators and the Generator (as defined in Section 16.8) (all of the foregoing listed in this ​Subsection 5(z) shall be referred to herein as, the “Existing Systems”) in good working ​ condition and in compliance with all Applicable Laws (including, without limitation, the ADA ​ inclusive of path of travel requirements to the extent required in order to obtain a final sign off ​ on the permits for the Pre-Delivery Landlord Work) (the “Delivery Requirement”). Tenant’s ​ taking of possession of the Premises shall, except as otherwise agreed to in writing by Landlord ​ and Tenant, conclusively establish that the Premises, the Building and the Project were at such ​ time in good, sanitary and satisfactory condition and repair and that the Delivery Requirement ​ was satisfied; provided that, if Landlord fails to satisfy the Delivery Requirement (a “Delivery ​ Shortfall”), then Tenant may, as its sole and exclusive remedy, deliver notice to Landlord ​ detailing the nature of such failure (a “Shortfall Notice”); provided, further, that any Shortfall ​ Notice must be received by Landlord no later than the date (the “Shortfall Notice Deadline”) that ​ is thirty (30) days after the Term Commencement Date. In the event that Landlord receives a ​ Shortfall Notice on or before the Shortfall Notice Deadline, Landlord shall, at Landlord’s ​ ​ 11 ​ expense, promptly remedy the Delivery Shortfall. Landlord shall not have any obligations or ​ liabilities in connection with (aa) a failure to satisfy the Delivery Requirement except to the ​ extent such failure is identified by Tenant in a Shortfall Notice delivered to Landlord on or ​ before the Shortfall Notice Deadline, or (bb) any failure of the Pre-Delivery Landlord Work or ​ the Existing Systems to be in good working condition or in compliance with Applicable Laws ​ due to any event, circumstance or other factor arising or occurring after Landlord’s delivery of ​ the Premises to Tenant (including, without limitation, (i) any act or omission of Tenant, Tenant’s ​ contractors or subcontractors, or any of their respective employees, agents or invitees, (ii) the ​ construction of the Tenant Improvements or (iii) Tenant’s failure to properly repair or maintain ​ the Premises as required by this Lease), and no Delivery Shortfall shall be deemed to have ​ occurred as a result thereof. ​ ​ 6. Rentable Area. ​ 6.1. The term “Rentable Area” shall reflect such areas as reasonably calculated by ​ Landlord’s architect, as the same may be reasonably adjusted from time to time by Landlord in ​ consultation with Landlord’s architect to reflect changes to the Premises, the Building or the ​ Project, as applicable. ​ ​ 6.2. The Rentable Area of the Building is generally determined by making separate ​ calculations of Rentable Area applicable to each floor within the Building and totaling the ​ Rentable Area of all floors within the Building. The RentableArea of a floor is computed by ​ measuring to the outside finished surface of the permanent outer Building walls. The full area ​ calculated as previously set forth is included as Rentable Area, without deduction for columns ​ and projections or vertical penetrations, including stairs, elevator shafts, flues, pipe shafts, ​ vertical ducts and the like, as well as such items’ enclosing walls. ​ ​ 6.3. The term “Rentable Area,” when applied to the Premises, is that area equal to the ​ usable area of the Premises, plus an equitable allocation of Rentable Area within each Building ​ that is not then utilized or expected to be utilized as usable area, including that portion of the ​ Building devoted to corridors, equipment rooms, restrooms, elevator lobby, atrium and ​ mailroom. ​ ​ 6.4. ​ the Project. ​ The Rentable Area of the Project is the total Rentable Area of all buildings within ​ ​ 6.5. Review of allocations of Rentable Areas as between tenants of the Building and ​ the Project shall be made as frequently as Landlord deems appropriate, including in order to ​ facilitate an equitable apportionment of Operating Expenses (as defined below); provided, ​ however, that notwithstanding Landlord’s right to review such allocations of Rentable Areas, ​ Tenant’s Base Rent and Tenant’s Pro Rata Shares shall not be subject to increase other than in ​ connection with an actual physical modification of the Building or Project. If such review is by ​ a licensed architect and allocations are certified by such licensed architect as beingcorrect, then ​ Tenant shall be bound by such certifications. ​ ​ 12 ​ 7. Rent. ​ 7.1. ​ ​ Tenant shall pay to Landlord as Base Rent for the Premises, commencing on the ​ Term Commencement Date, the sums set forth in Section 2.3, subject to the rental adjustments ​ provided in Article 8 hereof. Base Rent shall be paid in equal monthly installments as set forth ​ in Section 2.3, subject to the rental adjustments provided in Article 8 hereof, each in advance on ​ the first day of each and every calendar month during the Term. ​ ​ 7.2. In addition to Base Rent, Tenant shall pay to Landlord as additional rent ​ (“Additional Rent”) at times hereinafter specified in this Lease (a) Tenant’s Adjusted Share (as ​ defined below) of Operating Expenses (as defined below), (b) the Property Management Fee (as ​ defined below), (c) [Intentionally omitted] and (d) any other amounts that Tenant assumes or ​ agrees to pay under the provisions of this Lease that are owed to Landlord, including any and all ​ other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to ​ comply with the agreements, terms, covenants and conditions of this Lease to be performed by ​ Tenant, after notice and the lapse of any applicable cure periods. ​ ​ 7.3. Base Rent and Additional Rent shall together be denominated “Rent.” Rent shall ​ be paid to Landlord, without abatement, deduction or offset, in lawful money of the United ​ States of America (i) to the address set forth in Section 2.8, (ii) via direct deposit (ACH) to a ​ bank account designated by Landlord, or (iii) or tosuch other person or at such other place as ​ Landlord may from time designate in writing. In the event the Term commences or ends on a ​ day other than the first day of a calendar month, then the Rent for such fraction of a month shall ​ be prorated for such period on the basis of the number of days in the month and shall be paid at ​ the then-current rate for such fractional month. ​ ​ 7.4. Except as otherwise provided in this Lease, Tenant’s obligation to pay Rent shall ​ not be discharged or otherwise affected by (a) any Applicable Laws now or hereafter applicable ​ to the Premises, (b) any other restriction on Tenant’s use, (c) except as expressly provided ​ herein, any casualty or taking or (d) any other occurrence; and Tenant waives all rights now or ​ hereafter existing to terminate or cancel this Lease or quit or surrender the Premises or any part ​ thereof, or to assert any defense in the nature of constructive eviction to any action seeking to ​ recover rent. Tenant’s obligation to pay Rent with respect to any period or obligations arising, ​ existing or pertaining to the period prior to the date of the expiration or earlier termination of the ​ Term or this Lease shall survive any such expiration or earlier termination; provided, however, ​ that nothing in this sentence shall in any way affect Tenant’s obligations with respect to any ​ other period. ​ ​ 8. Rent Adjustments. Base Rent shall be subject to an annual upward adjustment of three ​ percent (3%) of the then-current Base Rent. The first such adjustment shallbecome effective ​ commencing on the first (1st) annual anniversary of the Term Commencement Date, and ​ subsequent adjustments shall become effective on every successive annual anniversary for so ​ long as this Lease continues in effect. ​ ​ 9. Operating Expenses. ​ 9.1. As used herein, the term “Operating Expenses” shall include: ​ ​ 13 ​ (a) Government impositions, including property tax costs consisting of real ​ and personal property taxes (including amounts due under any improvement bond upon the ​ Building or the Project (including the parcel or parcels of real property upon which the Building, ​ the other buildings in the Project and areas serving the Building and the Project are located)) or ​ assessments in lieu thereof imposed by any federal, state, regional, local or municipal ​ governmental authority, agency or subdivision (each, a “Governmental Authority”); taxes on or ​ measured by gross rentals received from the rental of space in the Project; taxes based on the ​ square footage of the Premises, the Building or the Project, as well as any parking charges, ​ utilities surcharges or any other costs levied, assessed or imposed by, or at the direction of, or ​ resulting from Applicable Laws or interpretations thereof, promulgated by any Governmental ​ Authority in connection with the use or occupancy of the Project or the parking facilities serving ​ the Project; taxes on this transaction or any document to which Tenant is a party creating or ​ transferring an interest in the Premises; and any expenses, including the reasonable cost of ​ attorneys or experts, reasonably incurred by Landlord in seeking reduction by the taxing ​ authority of the applicable taxes, less tax refunds obtained as a result of an application for review ​ thereof; and ​ ​ (b) All other costs of any kind paid or incurred by Landlord inconnection ​ with the operation or maintenance of the Building and the Project (including the Amenities ​ Center), which shall include costs of repairs and replacements to improvements within the ​ Project as appropriate to maintain the Project as required hereunder; costs of utilities furnished to ​ the Common Area; sewer fees; cable television; trash collection; cleaning, including windows ​ (including those of the Amenities Center); heating, ventilation and air-conditioning; wall and ​ window repair costs; waterproofing costs; maintenance of landscaping and grounds; snow ​ removal; maintenance of drives and parking areas; maintenance of the roof; security services and ​ devices; building supplies; maintenance or replacement of equipment utilized for operation and ​ maintenance of the Project; license, permit and inspection fees; sales, use and excise taxes on ​ goods and services purchased by Landlord in connection with the operation, maintenance or ​ repair of the Building or Project systems and equipment; telephone, postage, stationery supplies ​ and other expenses incurred in connection with the operation, maintenance or repair of the ​ Project; accounting, legal and other professional fees and expenses incurred in connection with ​ the Project; costs of furniture, draperies, carpeting, landscaping supplies, snow removal and ​ other customary and ordinary items of personal property provided by Landlord for use in ​ Common Area or in theProject office; capital expenditures incurred (i) in replacing obsolete ​ equipment, (ii) for the primary purpose of reducing Operating Expenses or (iii) required by any ​ Governmental Authority to comply with Applicable Laws that take effect or are first applicable ​ to the Project after the Execution Date or to ensure continued compliance with Applicable Laws ​ in effect as of the Execution Date, in each case amortized over the useful life thereof, as ​ reasonably determined by Landlord, in accordance with generally accepted accounting ​ principles; costs of complying with Applicable Laws (except to the extent such costs are incurred ​ to remedy non-compliance as of the Execution Date with Applicable Laws); costs to keep the ​ Project in compliance with, or costs or fees otherwise required under or incurred pursuant to any ​ CC&Rs (as defined below), including condominium fees (except to the extent such costs are ​ incurred to remedy non-compliance with any CC&Rs as of the Execution Date); insurance ​ premiums, including premiums for commercial general liability, property casualty, earthquake, ​ terrorism and environmental coverages; portions of insured losses paid by Landlord as part of the ​ ​ ​ deductible portion of a loss pursuant to the terms of insurance policies; service contracts; costs of ​ services of independent contractors retained to do work of a nature referenced above; and costs ​ of compensation (including employment taxes and fringe benefits) of all persons who perform ​ regular and recurring duties connected with the day-to-day operation and maintenance of the ​ Project, its equipment, the adjacent walks, landscaped areas, drives and parking areas, including ​ janitors, floor waxers, window washers, watchmen, gardeners, sweepers, plow truck drivers, ​ handymen, and engineering/maintenance/facilities personnel. ​ ​ (c) Notwithstanding the foregoing, Operating Expenses shall not include any ​ net income, franchise, capital stock, estate or inheritance taxes, or taxes that are the personal ​ obligation of Tenant or of another tenant of the Project; any leasing commissions; expenses that ​ relate to preparation of rental space for a tenant, including permit, license and inspection costs, ​ incurred with respect to the installation of tenant improvements made for any tenants occupying ​ space in the Project or incurred in renovating or otherwise improving, decorating, painting or ​ redecorating vacant space for tenants or other occupants of the Project (excluding, however, such ​ costs relating to any Common Areas of the Project or parking facilities); expenses of initial ​ development, construction and initial or future leasing of the Project,including grading, paving, ​ landscaping and decorating (as distinguished from maintenance, repair and replacement of the ​ foregoing), marketing costs, legal fees, accounting fees, space planners' fees, advertising and ​ promotional expenses, lease negotiation, lease enforcement, and brokerage and finders' fees ​ incurred in connection therewith; costs incurred by Landlord with respect to the Delivery ​ Requirement; costs incurred by Landlord with respect to any Delivery Shortfall; expenses related ​ to disputes with other tenants; costs of repairs to the extent reimbursed by payment of insurance ​ proceeds received by Landlord; interest, points, fees and principal payments related to loans to ​ Landlord or secured by a loan agreement, mortgage, deed of trust, security instrument or other ​ loan document covering the Project or a portion thereof (collectively, “Loan Documents”) ​ (provided that interest upon a government assessment or improvement bond payable in ​ installments shall constitute an Operating Expense under Subsection 9.1(a)); salaries, wages and ​ benefits of employees of Landlord; depreciation claimed by Landlord for tax purposes (provided ​ that this exclusion of depreciation is not intended to delete from Operating Expenses actual costs ​ of repairs and replacements that are provided for in Subsection 9.1(b)); taxes that are excluded ​ from Operating Expenses by the last sentence of Subsection 9.1(a); reserves for futurecapital ​ replacements; costs to repair the structural portions of the Building or foundations; costs or ​ expenses incurred in connection with the financing or sale of the Project or any portion thereof; ​ costs expressly excluded from Operating Expenses elsewhere in this Lease or that are charged to ​ or paid by Tenant under other provisions of this Lease; professional fees and disbursements and ​ other costs and expenses related to the ownership (as opposed to the use, occupancy, operation, ​ maintenance or repair) of the Project; any balloons, flowers or other gifts provided to any entity ​ whatsoever, to include, but not limited to, Tenant, other tenants, employees, vendors, ​ contractors, prospective tenants and agents; any “above standard” cleaning costs caused by ​ another tenant and relating to the Common Areas of the Project, including, but not limited to, ​ construction cleanup or special cleanings associated with parties/events and specific tenant ​ requirements, including related trash collection, removal, hauling and dumping; any “validated” ​ parking for any entity; costs of any “tap fees” or any sewer or water connection fees for the ​ benefit of any particular tenant in the Project; overhead and profit increment paid to Landlord or ​ to subsidiaries or affiliates of Landlord for goods and/or services in the Project to the extent the ​ ​ 14 ​ ​ ​ same exceeds the typical costs of such services rendered by qualified, "first-class" unaffiliated ​ third parties on a competitive basis; rentals and other related expenses incurred in leasing HVAC ​ systems, elevators or other items or equipment which if purchased, rather than rented, the cost of ​ which would be excluded from Operating Expenses as a capital cost, except equipment not ​ affixed to the Project which is used in providing janitorial or similar services to the Common ​ Areas of the Project, and, further excepting from this exclusion such equipment rented or leased ​ to remedy or ameliorate an emergency condition in the Project; costs, other than those incurred ​ in ordinary maintenance and repair, for sculpture, paintings, fountains or other objects of art in ​ the Common Areas of the Project; costs, including rent, associated with maintaining a leasing or ​ marketing office (as opposed to a management office) for the Project, and rent for any office ​ space occupied by Project management personnel to the extent (1) the size of such office space ​ exceeds the size of office space occupied by management personnel of the comparable buildings, ​ with adjustment where appropriate for the size of the applicable project, (2) the rental rate of ​ such office space exceeds the size or fair market rental value of office space occupied by ​ management personnel of the comparable buildings, with adjustment where appropriate for the ​ size of the applicable project; costs tothe extent resulting from the gross negligence, willful ​ misconduct or illegal acts of Landlord; costs resulting from the presence of Hazardous Materials ​ at the Project in violation of Applicable Laws as of the Execution Date, unless placed at the ​ Project by a Tenant Party; and costs incurred to remove, remedy, contain, or treat any Hazardous ​ Material brought into the Building or onto the Project after the Execution Date by Landlord; ​ costs (including, without limitation, fines, penalties, interest, and costs of repairs, replacements, ​ alterations and/or improvements) incurred to correct violations of Applicable Laws existing as of ​ the Execution Date, including, without limitation, any costs to correct building code violations ​ pertaining to the initial design or construction of the Building or any other improvements to the ​ Project, to the extent such violations exist as of the Execution Date under Applicable Laws; any ​ reserves of any kind, including, without limitation, replacement reserves, operating reserves, ​ reserves required by lenders or partners, reserves for bad debts or lost rent or any similar charge; ​ any costs relating to signage for another tenant of the Project; taxes, fees, charges or other ​ penalties incurred as a result of Landlord's failure, inability or unwillingness to make payments ​ when due and penalties and fines imposed by governmental authorities due to the gross ​ negligence or willful misconduct of Landlord; any advertising or promotional expenditures ​ account; any costs ofany parties, ceremonies or other events for tenants, Landlord, Landlord's ​ affiliates or other third parties and any expenses incurred by Landlord for use of any portions of ​ the Project to accommodate filming or photography beyond the normal expenses otherwise ​ attributable to providing services, such as lighting and HVAC to such public portions of the ​ Project in normal Project operations during standard hours of operation for the Project; any costs ​ or expenses incurred by Landlord in connection with satellite dishes or similar specialized ​ communications equipment of third parties, tenants or occupants in or about the Project; and any ​ item that, if included in Operating Expenses, would involve a double collection for such item by ​ Landlord (including office rent for any property management office and expenses for which ​ Landlord is actually reimbursed or which are paid directly to the provider by any retail occupant ​ of the Project (e.g., utilities paid directly to the utility provider)); capital expenditures other than ​ those specifically authorized by subheadings (i)-(iii) in Article 9.1(b) above; costs for which ​ Landlord is actually reimbursed by other tenants or third parties; costs incurred in connection ​ with Landlord’s efforts to lease other space at the Project; expenses related to bad debt loss, rent ​ loss, or reserves for bad debts or rent loss; any costs unrelated to the Project and/or relating to ​ 15 ​ ​ ​ the business of Landlord generally (as opposed to costs relating to the operation of the Project); ​ and costs relating to charitable and political contributions). To the extent that Tenant uses more ​ than Tenant’s Pro Rata Share of any item of Operating Expenses, Tenant shall pay Landlord for ​ such excess in addition to Tenant’s obligation to pay Tenant’s Pro Rata Share of Operating ​ Expenses (such excess, together with Tenant’s Pro Rata Share, “Tenant’s Adjusted Share”). ​ ​ 9.2. Tenant shall pay to Landlord on the first day of each calendar month of the Term, ​ as Additional Rent, (a) the Property Management Fee (as defined below), (b) [Intentionally ​ omitted] and (c) Landlord’s estimate of Tenant’s Adjusted Share of Operating Expenses with ​ respect to the Building and the Project, as applicable, for such month. ​ ​ (w) The “Property Management Fee” shall equal three percent (3%) of Base ​ Rent due from Tenant. Tenant shall pay the Property Management Fee in accordance with ​ Section 9.2 with respect to the entire Term, including any extensions thereof or any holdover ​ periods, regardless of whether Tenant is obligated to pay Base Rent, Operating Expenses or any ​ other Rent with respect to any such period or portion thereof. For the first eight (8) months of the ​ Term, the Property Management Fee shall be calculated as if Tenant were paying Three Hundred ​ Two Thousand Nine Hundred Seventy-Nine and 20/100 Dollars ($302,979.20) per month for ​Base Rent. ​ ​ (x) [Intentionally omitted] ​ ​ (y) Within ninety (90) days after the conclusion of each calendar year (or such ​ longer period as may be reasonably required by Landlord), Landlord shall furnish to Tenant a ​ statement showing in reasonable detail the actual Operating Expenses, Tenant’s Adjusted Share ​ of Operating Expenses, and the cost of providing utilities to the Premises for the previous ​ calendar year (“Landlord’s Statement”). Any additional sum due from Tenant to Landlord shall ​ be due and payable within thirty (30) days after receipt of an invoice therefor. If the amounts ​ paid by Tenant pursuant to this Section exceed Tenant’s Adjusted Share of Operating Expenses ​ for the previous calendar year, then Landlord shall credit the difference against the Rent next due ​ and owing from Tenant; provided that, if the Lease term has expired, Landlord shall accompany ​ Landlord’s Statement with payment for the amount of such difference. ​ ​ (z) Any amount due under this Section for any period that is less than a full ​ month shall be prorated for such fractional month on the basis of the number of days in the ​ month. ​ ​ 9.3. Landlord may, from time to time, modify Landlord’s calculation and allocation ​ procedures for Operating Expenses, so long as such modifications produce Dollar results ​ substantially consistent with Landlord’s then-current practice at the Project. Landlord or an ​ affiliate(s) of Landlord currently own other property(ies) adjacent to the Project or its ​neighboring properties (collectively, “Neighboring Properties”). In connection with Landlord ​ performing services for the Project pursuant to this Lease, similar services may be performed by ​ the same vendor(s) for Neighboring Properties. In such a case, Landlord shall reasonably ​ allocate to each Building and the Project the costs for such services based upon the ratio that the ​ square footage of the Building or the Project (as applicable) bears to the total square footage of ​ all of the Neighboring Properties or buildings within the Neighboring Properties for which the ​ 16 ​ ​ ​ services are performed, unless the scope of the services performed for any building or property ​ (including the Building and the Project) is disproportionately more or less than for others, in ​ which case Landlord shall equitably allocate the costs based on the scope of the services being ​ performed for each building or property (including the Building and the Project). Since the ​ Project consists of multiple buildings, certain Operating Expenses may pertain to a particular ​ building(s) and other Operating Expenses to the Project as a whole. Landlord reserves the right ​ in its reasonable discretion to allocate any such costs applicable to any particular building within ​ the Project to such building, and other such costs applicable to the Project to each building in the ​ Project (including the Building), with the tenants in each building being responsible for paying ​ their respective proportionate shares of their buildings to the extent required under their leases. ​ Landlord shall allocate such costs to the buildings (including the Building) in a reasonable, non- ​ discriminatory manner, and such allocation shall be binding on Tenant. ​ ​ 9.4. Landlord's annual statement shall be final and binding upon Tenant unless Tenant, ​ within six (6) months after Tenant's receipt thereof, shall contest any item therein by giving ​ written notice to Landlord; provided that Tenant shall in all events pay the amount specified in ​ Landlord's annual statement, pending the results of the IndependentReview and determination of ​ the Accountant(s), as applicable and as each such term is defined below. If, during such six (6) ​ month period, Tenant reasonably and in good faith questions or contests the correctness of ​ Landlord's statement of Tenant's Share of Operating Expenses, Landlord shall provide Tenant ​ with reasonable access to Landlord's books and records to the extent relevant to determination of ​ Operating Expenses, and such information that is reasonably responsive to Tenant's written ​ inquiries. In the event that, after Tenant's review of such information, Landlord and Tenant ​ cannot agree upon the amount of Tenant's Share of Operating Expenses, then Tenant shall have ​ the right to have an independent public accounting firm hired by Tenant on an hourly basis and ​ not on a contingent-fee basis (at Tenant's sole cost and expense) and approved by Landlord ​ (which approval Landlord shall not unreasonably withhold or delay) audit and review such of ​ Landlord's books and records for the year in question as directly relate to the determination of ​ Operating Expenses for such year (the "Independent Review"), but not books and records of ​ entities other than Landlord. Landlord shall make such books and records available at the ​ location where Landlord maintains them in the ordinary course of its business. Landlord need ​ not provide copies of any books or records. Tenant shallcommence the Independent Review ​ within fifteen (15) days after the date Landlord has given Tenant access to Landlord's books and ​ records for the Independent Review. Tenant shall complete the Independent Review and notify ​ Landlord in writing of Tenant's specific objections to Landlord's calculation of Operating ​ Expenses (including Tenant's accounting firm's written statement of the basis, nature and amount ​ of each proposed adjustment) no later than sixty (60) days after Landlord has first given Tenant ​ access to Landlord's books and records for the Independent Review. Landlord shall review the ​ results of any such Independent Review. The parties shall endeavor to agree promptly and ​ reasonably upon Operating Expenses taking into account the results of such Independent ​ Review. If, as of sixty (60) days after Tenant has submitted the Independent Review to ​ Landlord, the parties have not agreed on the appropriate adjustments to Operating Expenses, ​ then the parties shall engage a mutually agreeable independent third party accountant with at ​ least ten (10) years' experience in commercial real estate accounting in the San Diego area (the ​ "Accountant"). If the parties cannot agree on the Accountant, each shall within ten (10) days ​ after such impasse appoint an Accountant (different from the accountant and accounting firm ​ ​ 17 ​ ​ ​ that conducted the Independent Review) and, within ten (10) days after the appointment of both ​ such Accountants, those two Accountants shall select a third (which cannot be the accountant ​ and accounting firm that conducted the Independent Review). If either party fails to timely ​ appoint an Accountant, then the Accountant the other party appoints shall be the sole ​ Accountant. Within ten (10) days after appointment of the Accountant(s), Landlord and Tenant ​ shall each simultaneously give the Accountants (with a copy to the other party) its determination ​ of Operating Expenses, with such supporting data or information as each submitting party ​ determines appropriate. Within ten (10) days after such submissions, the Accountants shall by ​ majority vote select either Landlord's or Tenant's determination of Operating Expenses. The ​ Accountants may not select or designate any other determination of Operating Expenses. The ​ determination of the Accountant(s) shall bind the parties. If the parties agree or the ​ Accountant(s) determine that the Operating Expenses actually paid by Tenant for the calendar ​ year in question exceeded Tenant's obligations for such calendar year, then Landlord shall, at ​ Tenant's option, either (a) credit the excess to the next succeeding installments of estimated ​ Additional Rent or (b) pay the excess to Tenant within thirty (30) days after delivery of such ​ results. If the parties agree or the Accountant(s) determine thatTenant's payments of Operating ​ Expenses for such calendar year were less than Tenant's obligation for the calendar year, then ​ Tenant shall pay the deficiency to Landlord within thirty (30) days after delivery of such results. ​ If the Independent Review reveals or the Accountant(s) determine that the Operating Expenses ​ billed to Tenant by Landlord and paid by Tenant to Landlord for the applicable calendar year in ​ question exceeded by more than five percent (5%) what Tenant should have been billed during ​ such calendar year, then Landlord shall pay the reasonable cost of the Independent Review and ​ the reasonable cost of the Accountant(s). In all other cases Tenant shall pay the cost of the ​ Independent Review and the Accountant(s). ​ ​ 9.5. Notwithstanding anything to the contrary in this Lease, the aggregate Controllable ​ Operating Expenses (as defined below) shall not increase by more than five percent (5%) in any ​ calendar year over the amount of Controllable Operating Expenses actually charged to Tenant ​ for the immediately preceding calendar year (the “Cap”), beginning with the 2019 calendar ​ year’s Operating Expenses (i.e., comparing 2018 to 2019 (on a prorated basis, if necessary)). ​ For the avoidance of doubt, the Cap shall apply to each year of the Term beginning with the ​ calendar year 2019, so that Controllable Operating Expenses for calendar year 2019 shall not ​ exceed one hundred fivepercent (105%) of Controllable Operating Expenses actually charged ​ for calendar year 2018 (on a prorated basis, if necessary), Controllable Operating Expenses for ​ calendar year 2020 shall not exceed one hundred five percent (105%) of Controllable Operating ​ Expenses actually charged for 2019, etc. “Controllable Operating Expenses” means all Operating ​ Expenses except property taxes and assessments, capital expenditures that are reasonably ​ required, costs for repairs and maintenance (excluding preventative maintenance), utility ​ charges, insurance charges, costs of services provided under a union contract, payments under ​ covenants, conditions and restrictions or to an owners’ association and costs associated with ​ repairs due to casualty, vandalism or other cause outside of Landlord’s reasonable control. ​ ​ 9.6. Tenant shall not be responsible for Operating Expenses with respect to any time ​ period prior to the Term Commencement Date; provided, however, that if Tenant substantially ​ completes the Tenant Improvements and occupies the Premises for the conduct of its business ​ prior to the Term Commencement Date, Tenant shall be responsible for Operating Expenses ​ ​ 18 ​ ​ 19 ​ from such earlier date of possession (the Term Commencement Date or such earlier date, as ​ applicable, the “Expense Trigger Date”); and provided, further, that Landlord may annualize ​ certain Operating Expenses incurred prior to the Expense Trigger Date over the course of the ​ budgeted year during which the Expense Trigger Date occurs, and Tenant shall be responsible ​ for the annualized portion of such Operating Expenses corresponding to the number of days ​ during such year, commencing with the Expense Trigger Date, for which Tenant is otherwise ​ liable for Operating Expenses pursuant to this Lease. Tenant’s responsibility for Tenant’s ​ Adjusted Share of Operating Expenses shall continue to the latest of (a) the date of termination ​ of the Lease, (b) the date Tenant has fully vacated the Premises and (c) if termination of the ​ Lease is due to a default by Tenant, the date that is the later of (i) the scheduled expiration date ​ of this Lease (as of the date of such default) and (ii) the rental commencement of a replacement ​ tenant. ​ ​ 9.7. Operating Expenses for the calendar year in which Tenant’s obligation to share ​ therein commences and for the calendar year in which such obligation ceases shall be prorated ​ based on the actual number of days applicable to Tenant’s obligation during such calendar year. ​ Expenses such as taxes, assessments and insurance premiums that are incurred for an extended ​ time period shall beprorated based upon the time periods to which they apply so that the ​ amounts attributed to the Premises relate in a reasonable manner to the time period wherein ​ Tenant has an obligation to share in Operating Expenses. ​ ​ 9.8. Within thirty (30) days after the end of each calendar month, Tenant may submit ​ to Landlord an invoice, or, in the event an invoice is not available, an itemized list, of all costs ​ and expenses that (a) Tenant has incurred (either internally or by employing third parties) during ​ the prior month and (b) for which Tenant reasonably believes it is entitled to reimbursements ​ from Landlord pursuant to the terms of this Lease or that Tenant reasonably believes is the ​ responsibility of Landlord pursuant to this Lease or the Work Letter. ​ ​ 9.9. In the event that the Project is less than fully occupied during a calendar year, ​ Tenant acknowledges that Landlord may extrapolate Operating Expenses that vary depending on ​ the occupancy of the Project, as applicable, to equal Landlord’s reasonable estimate of what such ​ Operating Expenses would have been had the Project, as applicable, been ninety-five percent ​ (95%) occupied during such calendar year; provided, however, that Landlord shall not recover ​ more than one hundred percent (100%) of Operating Expenses. ​ ​ 10. Taxes on Tenant’s Property. ​ ​ 10.1. Tenant shall be solely responsible for the payment of any and all taxes levied ​ upon (a) personal property and trade fixtureslocated at the Premises and (b) any gross or net ​ receipts of or sales by Tenant, and shall pay the same prior to delinquency. ​ ​ 10.2. If any such taxes on Tenant’s personal property or trade fixtures are levied against ​ Landlord or Landlord’s property or, if the assessed valuation of the Building, the Property or the ​ Project is increased by inclusion therein of a value attributable to Tenant’s personal property or ​ trade fixtures, and if Landlord, after written notice to Tenant, pays the taxes based upon any such ​ increase in the assessed value of the Building, the Property or the Project, then Tenant shall, ​ upon demand, repay to Landlord the taxes so paid by Landlord. ​ ​ 20 ​ 10.3. If any improvements in or alterations to the Premises, whether owned by ​ Landlord or Tenant and whether or not affixed to the real property so as to become a part ​ thereof, are assessed for real property tax purposes at a valuation higher than the valuation at ​ which improvements conforming to Landlord’s building standards (the “Building Standard”) in ​ other spaces in the Building are assessed, then the real property taxes and assessments levied ​ against Landlord or the Building, the Property or the Project by reason of such excess assessed ​ valuation shall be deemed to be taxes levied against personal property of Tenant and shall be ​ governed by the provisions of Section 10.2. Any such excess assessed valuation due to ​ improvements in or alterations to space in the Project leased by other tenants at the Project shall ​ not be included in Operating Expenses. If the records of the applicable governmental assessor’s ​ office are available and sufficiently detailed to serve as a basis for determining whether such ​ Tenant improvements or alterations are assessed at a higher valuation than the Building ​ Standard, then such records shall be binding on both Landlord and Tenant. ​ ​ 11. Security Deposit. ​ 11.1. Tenant shall deposit with Landlord on or before the Execution Date, the sum of ​ Three Hundred Two Thousand Nine Hundred Seventy-Nine and 20/100 Dollars ($302,979.20) ​ toward the Security Deposit set forthin Section 2.6. Within five (5) business days after the ​ earlier of (i) the Clinical Trial Termination Outside Date or (ii) the date Tenant waives the ​ Clinical Trial Termination Option, Tenant will deposit the remaining Six Hundred Five ​ Thousand Nine Hundred Fifty-Eight and 40/100 Dollars ($605,958.40) (which, together with the ​ initial payment above, shall be collectively referred to as the “Security Deposit”). The Security ​ Deposit shall be held by Landlord as security for the faithful performance by Tenant of all of the ​ terms, covenants and conditions of this Lease to be kept and performed by Tenant during the ​ period commencing on the Execution Date and ending upon the expiration or termination of ​ Tenant’s obligations under this Lease. If Tenant Defaults (as defined below) with respect to any ​ provision of this Lease, including any provision relating to the payment of Rent, then Landlord ​ may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for ​ the payment of any Rent or any other sum in default, or to compensate Landlord for any other ​ loss or damage that Landlord may suffer by reason of Tenant’s default. If any portion of the ​ Security Deposit is so used or applied, then Tenant shall, within ten (10) days following demand ​ therefor, restore the Security Deposit to the amount then required hereunder, and Tenant’s failure ​ to do so shall be a material breach of this Lease. The provisions of this Article shall survive the ​ expiration or earlier termination of thisLease. TENANT HEREBY WAIVES THE ​ REQUIREMENTS OF SECTION 1950.7 OF THE CALIFORNIA CIVIL CODE, AS THE ​ SAME MAY BE AMENDED FROM TIME TO TIME. ​ ​ 11.2. In the event of bankruptcy or other debtor-creditor proceedings against Tenant, ​ the Security Deposit shall be deemed to be applied first to the payment of Rent and other charges ​ due Landlord for all periods prior to the filing of such proceedings. ​ ​ 11.3. Landlord may deliver to any purchaser of Landlord’s interest in the Premises the ​ funds deposited hereunder by Tenant, and thereupon Landlord shall be discharged from any ​ further liability with respect to such deposit. This provision shall also apply to any subsequent ​ transfers. ​ ​ 21 ​ 11.4. If Tenant shall fully and faithfully perform every provision of this Lease to be ​ performed by it, then the Security Deposit, or any balance thereof, shall be returned to Tenant ​ (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) ​ days after the expiration or earlier termination of this Lease. ​ ​ 11.5. If the Security Deposit shall be in cash, Landlord shall hold the Security Deposit ​ in an account at a banking organization selected by Landlord; provided, however, that Landlord ​ shall not be required to maintain a separate account for the Security Deposit, but may ​ intermingle it with other funds of Landlord. Landlord shall be entitled to all interest and/or ​ dividends, if any, accruing on the Security Deposit. Landlord shall not be required to credit ​ Tenant with any interest for any period during which Landlord does not receive interest on the ​ Security Deposit. ​ ​ 11.6. The Security Deposit may be in the form of cash, a letter of credit or any other ​ security instrument acceptable to Landlord in its sole discretion. Tenant may at any time, except ​ when Tenant is in Default (as defined below), deliver a letter of credit (the “L/C Security”) as the ​ entire Security Deposit, as follows: ​ ​ (a) If Tenant elects to deliver L/C Security, then Tenant shall provide ​ Landlord, and maintain in full force and effect throughout the Term and until the date that is six ​ (6) months after the then-current Term Expiration Date, a letter of credit in the form of Exhibit E ​ issued by an issuer reasonably satisfactory to Landlord, in theamount of the Security Deposit, ​ with an initial term of at least one year. Landlord may require the L/C Security to be re-issued ​ by a different issuer at any time during the Term if Landlord reasonably believes that the issuing ​ bank of the L/C Security is or may soon become insolvent; provided, however, Landlord shall ​ return the existing L/C Security to the existing issuer immediately upon receipt of the substitute ​ L/C Security. If any issuer of the L/C Security shall become insolvent or placed into FDIC ​ receivership, then Tenant shall immediately deliver to Landlord (without the requirement of ​ notice from Landlord) substitute L/C Security issued by an issuer reasonably satisfactory to ​ Landlord, and otherwise conforming to the requirements set forth in this Article. As used herein ​ with respect to the issuer of the L/C Security, “insolvent” shall mean the determination of ​ insolvency as made by such issuer’s primary bank regulator (i.e., the state bank supervisor for ​ state chartered banks; the OCC or OTS, respectively, for federally chartered banks or thrifts; or ​ the Federal Reserve for its member banks). If, at the Term Expiration Date, any Rent remains ​ uncalculated or unpaid, then (i) Landlord shall with reasonable diligence complete any necessary ​ calculations, (ii) Tenant shall extend the expiry date of such L/C Security from time to time as ​ Landlord reasonably requires and (iii) in such extended period, Landlord shall not unreasonably ​ refuse to consent to an appropriate reduction of the L/CSecurity. Tenant shall reimburse ​ Landlord’s actual third-party legal costs in handling any dispute or draw request relating to ​ Tenant’s L/C Security, if any. ​ ​ (b) If Tenant delivers to Landlord satisfactory L/C Security in place of the ​ entire Security Deposit, Landlord shall remit to Tenant any cash Security Deposit Landlord ​ previously held. ​ ​ (c) Landlord may draw upon the L/C Security, and hold and apply the ​ proceeds in the same manner and for the same purposes as the Security Deposit, if (i) an uncured ​ ​ ​ Default (as defined below) exists, (ii) as of the date that is forty-five (45) days before any L/C ​ Security expires (even if such scheduled expiry date is after the Term Expiration Date) Tenant ​ has not delivered to Landlord an amendment or replacement for such L/C Security, reasonably ​ satisfactory to Landlord, extending the expiry date to the earlier of (1) six (6) months after the ​ then-current Term Expiration Date or (2) the date that is one year after the then-current expiry ​ date of the L/C Security, (iii) the L/C Security provides for automatic renewals, Landlord asks ​ the issuer to confirm the current L/C Security expiry date, and the issuer fails to do so within ten ​ (10) business days, (iv) Tenant fails to pay (when and as Landlord reasonably requires) any bank ​ charges for Landlord’s transfer of the L/C Security or (v) the issuer of the L/C Security ceases, ​ or announces that it will cease, to maintain an office in the city where Landlord may present ​ drafts under the L/C Security (and fails to permit drawing upon the L/C Security by overnight ​ courier or facsimile). This Section does not limit any other provisions of this Lease allowing ​ Landlord to draw the L/C Security under specified circumstances. ​ ​ (d) Tenant shall not seek to enjoin, prevent, or otherwise interfere with ​ Landlord’s draw under L/C Security, even if it violates this Lease. Tenant acknowledges that the ​ only effect of a wrongful draw would be to substitute a cash Security Deposit for L/C Security, ​ causing Tenant no legally recognizable damage.Landlord shall hold the proceeds of any draw in ​ the same manner and for the same purposes as a cash Security Deposit. In the event of a ​ wrongful draw, the parties shall cooperate to allow Tenant to post replacement L/C Security ​ simultaneously with the return to Tenant of the wrongfully drawn sums, and Landlord shall upon ​ request confirm in writing to the issuer of the L/C Security that Landlord’s draw was erroneous. ​ ​ (e) If Landlord transfers its interest in the Premises, then Tenant shall at ​ Tenant’s expense, within five (5) business days after receiving a request from Landlord, deliver ​ (and, if the issuer requires, Landlord shall consent to) an amendment to the L/C Security naming ​ Landlord’s grantee as substitute beneficiary. If the required Security Deposit changes while L/C ​ Security is in force, then Tenant shall deliver (and, if the issuer requires, Landlord shall consent ​ to) a corresponding amendment to the L/C Security. ​ ​ 11.7 Notwithstanding anything to the contrary contained in this Section 11, in the ​ event that Tenant, at the expiration of the twenty-fourth (24th) month of the initial Term, is not ​ in Default of any of its obligations under this Lease, and has not been in Default of any of its ​ obligations under this Lease at any time during the previous twelve (12) month period, Landlord ​ shall reduce the amount of the Security Deposit by Three Hundred Two Thousand Nine ​ Hundred Seventy-Nine and 20/100 Dollars ($302,979.20) and Landlord shall, at Tenant’s ​ optioneither apply such amount against Tenant's monthly Base Rent obligation for the twenty- ​ fifth (25h) month of the initial Term or refund such amount to Tenant within thirty (30) days. ​ Further, in the event that Tenant, at the expiration of the sixtieth (60th) month of the initial ​ Term, is not in default of any of its obligations under this Lease, and has not been in default of ​ any of its obligations under this Lease at any time during the previous twelve (12) month ​ period, Landlord shall further reduce the amount of the Security Deposit by Three Hundred ​ Two Thousand Nine Hundred Seventy-Nine and 20/100 Dollars ($302,979.20) and Landlord ​ shall, at Tenant’s option either apply such amount against Tenant's monthly Base Rent ​ obligation for the sixty-first (61st) month of the initial Term or refund such amount to Tenant ​ within thirty (30) days. ​ ​ 22 ​ ​ ​ 12. Use. ​ 12.1. ​ ​ Tenant shall use the Premises for the Permitted Use, and shall not use the ​ Premises, or permit or suffer the Premises to be used, for any other purpose without Landlord’s ​ prior written consent, which consent Landlord may withhold in its sole and absolute discretion. ​ ​ 12.2. Tenant shall not use or occupy the Premises in violation of Applicable Laws; ​ zoning ordinances; or the certificate of occupancy (or its substantial equivalent) issued for the ​ Building or the Project, and shall, upon ten (10) days’ written notice from Landlord, discontinue ​ any use of the Premises that is, or is declared or claimed by any Governmental Authority having ​ jurisdiction to be a violation of any of the above. Tenant shall comply with any direction of any ​ Governmental Authority having jurisdiction that shall, by reason of the nature of Tenant’s use or ​ occupancy of the Premises, impose any duty upon Tenant or Landlord with respect to the ​ Premises or with respect to the use or occupation thereof, and shall indemnify, defend (at the ​ option of and with counsel reasonably acceptable to the indemnified party(ies)), save, reimburse ​ and hold harmless (collectively, “Indemnify,” “Indemnity” or “Indemnification,” as the case may ​ require) the Landlord and its affiliates, employees, agents and contractors; and any lender, ​ mortgagee, ground lessor or beneficiary (each, a “Lender” and, collectively with Landlord and ​ its affiliates, employees, agents and contractors, the “Landlord Indemnitees”)harmless from and ​ against any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, ​ damages, suits or judgments, and all reasonable expenses (including reasonable attorneys’ fees, ​ charges and disbursements, regardless of whether the applicable demand, claim, action, cause of ​ action or suit is voluntarily withdrawn or dismissed) incurred in investigating or resisting the ​ same (collectively, “Claims”) of any kind or nature that arise before, during or after the Term as ​ a result of Tenant’s breach of this Section. ​ ​ 12.3. Tenant shall not do or permit to be done anything that will invalidate or increase ​ the cost of any fire, environmental, extended coverage or any other insurance policy covering the ​ Building or the Project, and shall comply with all rules, orders, regulations and requirements of ​ the insurers of the Building and the Project, and Tenant shall promptly, upon demand, reimburse ​ Landlord for any additional premium charged for such policy by reason of Tenant’s failure to ​ comply with the provisions of this Article. ​ ​ 12.4. Tenant shall keep all doors opening onto public corridors closed, except when in ​ use for ingress and egress. ​ ​ 12.5. No additional locks or bolts of any kind shall be placed upon any of the doors or ​ windows by Tenant, nor shall any changes be made to existing locks or the mechanisms thereof ​ (including card readers) without Landlord’s prior written consent. Tenant shall, upon ​ termination of this Lease,return to Landlord all keys or other opening mechanisms to offices and ​ restrooms either furnished to or otherwise procured by Tenant. In the event any key so furnished ​ to Tenant is lost, Tenant shall pay to Landlord the cost of replacing the same or of changing the ​ lock or locks opened by such lost key if Landlord shall deem it necessary to make such change. ​ ​ 12.6. No awnings or other projections shall be attached to any outside wall of the ​ Building. No curtains, blinds, shades or screens shall be attached to or hung in, or used in ​ connection with, any window or door of the Premises other than Landlord’s standard window ​ ​ 23 ​ ​ ​ coverings. Neither the interior nor exterior of any windows shall be coated or otherwise ​ sunscreened without Landlord’s prior written consent, nor shall any bottles, parcels or other ​ articles be placed on the windowsills or items attached to windows that are visible from outside ​ the Premises. No equipment, furniture or other items of personal property shall be placed on any ​ exterior balcony without Landlord’s prior written consent. Notwithstanding any of the above, ​ Tenant may deviate from this Section with Landlord’s prior written consent (which may be given ​ or withheld in Landlord’s sole and absolute discretion); provided, however, that if such ​ deviations were part of the Approved Plans, then no further Landlord consent will be required. ​ ​ 12.7. No sign, advertisement or notice (“Signage”) shall be exhibited, painted or ​ affixed by Tenant to the exterior of the Building without Landlord’s prior written consent; ​ provided, however, that Landlord acknowledges that Tenant shall be entitled to the following ​ Signage (subject to compliance with all Applicable Laws and Tenant’s receipt of all necessary ​ approvals and permits): (i) Building top, (ii) lobby, (iii) directory, and (iv) suite signage. ​ Landlord shall not unreasonably withhold its consent to any Signage on or in the Building that ​ complies with Applicable Laws; provided, however, that Landlord’s approval shall not be ​ required for Signage that is not visible from the exterior of the Building. Signage shall conform ​ to Landlord’s design criteria. Forany Signage, Tenant shall, at Tenant’s own cost and expense, ​ (a) acquire all permits for such Signage in compliance with Applicable Laws and (b) design, ​ fabricate, install and maintain such Signage in a first-class condition. Tenant shall be ​ responsible for reimbursing Landlord for reasonable, out-of-pocket costs incurred by Landlord in ​ removing any of Tenant’s Signage upon the expiration or earlier termination of the Lease. ​ Interior signs on entry doors to the Premises and the directory tablet (if any) shall be inscribed, ​ painted or affixed for Tenant by Landlord at Tenant’s sole cost and expense, and shall be of a ​ size, color and type and be located in a place reasonably acceptable to Landlord. The directory ​ tablet shall be provided exclusively for the display of the name and location of tenants only. ​ Tenant shall not place anything on the exterior of the corridor walls or corridor doors other than ​ Landlord’s standard lettering. Upon Tenant’s request, Landlord may install any Tenant Signage, ​ and Tenant shall pay all costs associated with such installation within thirty (30) days after ​ receipt of an invoice. ​ ​ 12.8. Tenant may only place equipment within the Premises with floor loading ​ consistent with the Building’s structural design unless Tenant obtains Landlord’s prior written ​ approval. Tenant may place such equipment only in a location designed to carry the weight of ​ such equipment. ​ ​ 12.9. Tenant shall cause any equipment or machinery tobe installed in the Premises so ​ as to reasonably prevent sounds or vibrations therefrom from extending into the Common Area ​ or other offices in the Project. ​ ​ 12.10. Tenant shall not (a) do or permit anything to be done in or about the Premises that ​ shall in any way obstruct or interfere with the rights of other tenants or occupants of the Project, ​ or injure or annoy them, (b) use or allow the Premises to be used for immoral, unlawful or ​ objectionable purposes, (c) cause, maintain or permit any nuisance or waste in, on or about the ​ Project or (d) take any other action that would in Landlord’s reasonable determination in any ​ manner adversely affect other tenants’ quiet use and enjoyment of their space or adversely ​ ​ 24 ​ ​ ​ impact their ability to conduct business in a professional and suitable work environment. ​ Notwithstanding anything in this Lease to the contrary, Tenant may not install any security ​ systems (including cameras) outside the Premises or that record sounds or images outside the ​ Premises (collectively, “Security Cameras”) without Landlord’s prior written consent, which ​ Landlord may withhold in its sole and absolute discretion Notwithstanding the foregoing, ​ Landlord will not unreasonably withhold consent to the installation of Security Cameras which ​ monitor access points to, and the immediate perimeter of, the Building only; provided, however, ​ that (i) any such Security Cameras shall comply with all Applicable Laws (including all ​ surveillance notification procedures required thereby), (ii) the cost of any repair, maintenance ​ and replacement of any such Security Cameras shall be Tenant’s sole responsibility, (iii) upon ​ Landlord’s request, Landlord shall have the right to view and obtain a copy of any footage ​ recorded by any such Security Cameras, (iv) the installation and use of any such Security ​ Cameras shall be subject to all applicable provisions of this Lease (including, without limitation, ​ Article 17) and (v) Tenant shall indemnify, save, defend (at Landlord’s option and with counsel ​ reasonably acceptable to Landlord) and hold the Landlord Indemnitees harmless from and ​ against any and all Claims arising directly or indirectly out of, or in any way related to(x) any ​ such Security Cameras, (y) Tenant’s use, misuse or nonuse of any such Security Cameras, or (z) ​ any footage recorded or not recorded by any such Security Cameras. ​ ​ 12.11. Notwithstanding any other provision herein to the contrary (but subject to ​ Landlord’s performance and satisfaction of the Delivery Requirement), Tenant shall be ​ responsible for all liabilities, costs and expenses arising out of or in connection with the ​ compliance of the Premises with the Americans with Disabilities Act, 42 U.S.C. § 12101, et seq., ​ and any state and local accessibility laws, codes, ordinances and rules (collectively, and together ​ with regulations promulgated pursuant thereto, the “ADA”), and Tenant shall Indemnify the ​ Landlord Indemnitees from and against Claims arising out of any such failure of the Premises to ​ comply with the ADA. The Premises have not undergone inspection by a Certified Access ​ Specialist (as defined in California Civil Code Section 55.52). For the avoidance of doubt, ​ “Lenders” shall also include historic tax credit investors and new market tax credit investors. ​ The provisions of this Section shall survive the expiration or earlier termination of this Lease. ​ ​ 12.12. Tenant shall maintain temperature and humidity in the Premises in accordance ​ with ASHRAE standards at all times. ​ ​ 13. Rules and Regulations, CC&Rs, Parking Facilities and Common Area. ​ 13.1. Tenant shall have the non-exclusive right, in common with others, to use the ​Common Area in conjunction with Tenant’s use of the Premises for the Permitted Use, and such ​ use of the Common Area and Tenant’s use of the Premises shall be subject to the rules and ​ regulations adopted by Landlord and attached hereto as Exhibit F, together with such other ​ reasonable and nondiscriminatory rules and regulations as are hereafter promulgated by ​ Landlord in its sole and absolute discretion (the “Rules and Regulations”). Tenant shall and ​ shall ensure that its contractors, subcontractors, employees, subtenants and invitees faithfully ​ observe and comply with the Rules and Regulations. Landlord shall not be responsible to Tenant ​ for the violation or non-performance by any other tenant or any agent, employee or invitee ​ thereof of any of the Rules and Regulations. ​ ​ ​ 25 ​ ​ ​ 13.2. This Lease is subject to any recorded covenants, conditions or restrictions on the ​ Project or Property, as the same may be amended, amended and restated, supplemented or ​ otherwise modified from time to time (the “CC&Rs”). Tenant shall, at its sole cost and expense, ​ comply with the CC&Rs. ​ ​ 13.3. Tenant shall have a non-exclusive, irrevocable license to use Tenant’s Pro Rata ​ Share of parking facilities serving the Project, which shall not be less than three (3) parking ​ spaces per 1,000 usable square feet of the Premises, in common on an unreserved basis with ​ other tenants of the Project during the Term at no additional cost. Tenant shall have the right to ​ designate up to twelve (12) spaces in the parking facility serving the Building at a location ​ reasonably approved by Landlord to be marked as reserved for visitors, carpools or loading. ​ ​ 13.4. Tenant agrees not to unreasonably overburden the parking facilities and agrees to ​ cooperate with Landlord and other tenants in the use of the parking facilities. Nothing in this ​ Section, however, is intended to create an affirmative duty on Landlord’s part to monitor ​ parking. ​ ​ 14. Project Control by Landlord. ​ 14.1. Landlord reserves full control over the Building and the Project to the extent not ​ inconsistent with Tenant’s enjoyment of the Premises as provided by this Lease. This ​ reservation includes Landlord’s right to subdivide the Project; convert the Building and other ​ buildings within the Project tocondominium units; change the size of the Project by selling all or ​ a portion of the Project or adding real property and any improvements thereon to the Project; ​ grant easements and licenses to third parties; maintain or establish ownership of the Building ​ separate from fee title to the Property; make additions to or reconstruct portions of the Building ​ and the Project; install, use, maintain, repair, replace and relocate for service to the Premises and ​ other parts of the Building or the Project pipes, ducts, conduits, wires and appurtenant fixtures, ​ wherever located in the Premises, the Building or elsewhere at the Project; and alter or relocate ​ any other Common Area or facility, including private drives, lobbies, entrances and landscaping; ​ provided, however, that such rights shall be exercised in a way that does not materially adversely ​ affect Tenant’s rights or obligations under the Lease, including the Permitted Use and Tenant’s ​ access to the Premises. ​ ​ 14.2. Landlord shall have the right to access areas of the Premises necessary for ​ utilities, services, safety and operation of the Building. ​ ​ 14.3. Tenant shall, at Landlord’s request, promptly execute such further documents as ​ may be reasonably appropriate to assist Landlord in the performance of its obligations ​ hereunder; provided that Tenant need not execute any document that creates additional liability ​ for Tenant or that deprives Tenant of the quiet enjoyment and use of the Premises as provided for ​ in this Lease. ​ ​ 14.4.Landlord may, at any and all reasonable times during non-business hours (or ​ during business hours, if (a) with respect to Subsections 14.4(u) through 14.4(y), Tenant so ​ requests, and (b) with respect to Subsection 14.4(z), if Landlord so requests), and upon one (1) ​ business days’ prior notice (which may be oral or by email to the office manager or other ​ ​ 26 ​ ​ 27 ​ Tenant-designated individual at the Premises; but provided that no time restrictions shall apply ​ or advance notice be required if an emergency necessitates immediate entry), enter the Premises ​ to (u) inspect the same and to determine whether Tenant is in compliance with its obligations ​ hereunder, (v) supply any service Landlord is required to provide hereunder, (w) alter, improve ​ or repair any portion of the Building other than the Premises for which access to the Premises is ​ reasonably necessary, (x) post notices of nonresponsibility, (y) access the telephone equipment, ​ electrical substation and fire risers and (z) show the Premises to prospective tenants during the ​ final year of the Term and current and prospective purchasers and lenders at any time. In ​ connection with any such alteration, improvement or repair as described in Subsection 14.4(w), ​ Landlord may erect in the Premises or elsewhere in the Project scaffolding and other structures ​ reasonably required for the alteration, improvement or repair work to be performed. In no event ​ shall Tenant’s Rent abate as a result of Landlord’s activities pursuant to this Section; provided, ​ however, that all such activities shall be conducted in such a manner so as to cause as little ​ interference to Tenant as is reasonably possible. Landlord shall at all times retain a key with ​ which to unlock all of the doors in the Premises. If an emergency necessitates immediate access ​ to the Premises, Landlord may usewhatever force is necessary to enter the Premises, and any ​ such entry to the Premises shall not constitute a forcible or unlawful entry to the Premises, a ​ detainer of the Premises, or an eviction of Tenant from the Premises or any portion thereof. ​ ​ 15. Quiet Enjoyment . Landlord covenants that Tenant, upon paying the Rent and ​ performing its obligations contained in this Lease, may peacefully and quietly have, hold and ​ enjoy the Premises, free from any claim by Landlord or persons claiming under Landlord, but ​ subject to all of the terms and provisions hereof, provisions of Applicable Laws and rights of ​ record to which this Lease is or may become subordinate. This covenant is in lieu of any other ​ quiet enjoyment covenant, either express or implied. ​ ​ 16. Utilities and Services. ​ 16.1. Tenant shall pay for all water (including the cost to service, repair and replace ​ reverse osmosis, de-ionized and other treated water), gas, heat, light, power, telephone, internet ​ service, cable television, other telecommunications and other utilities supplied to the Premises, ​ together with any fees, surcharges and taxes thereon. If any such utility is not separately metered ​ to Tenant, Tenant shall pay Tenant’s Adjusted Share of all charges of such utility jointly metered ​ with other premises as Additional Rent or, in the alternative, Landlord may, at its option, ​ monitor the usage of such utilities by Tenant and charge Tenant with the cost of such usage, ​ which cost shall be paid by Tenant asAdditional Rent. Landlord may base its bills for utilities ​ on reasonable estimates; provided that Landlord adjusts such billings promptly thereafter or as ​ part of the next Landlord’s Statement to reflect the actual cost of providing utilities to the ​ Premises. To the extent that Tenant uses more than Tenant’s Pro Rata Share of any utilities, then ​ Tenant shall pay Landlord for Tenant’s Adjusted Share of such utilities to reflect such excess. In ​ the event that the Project is less than fully occupied during a calendar year, Tenant acknowledges ​ that Landlord may extrapolate utility usage that varies depending on the occupancy of the Project ​ (as applicable) to equal Landlord’s reasonable estimate of what such utility usage would have ​ been had the Project, as applicable, been ninety-five percent (95%) occupied during such ​ calendar year; provided, however, that Landlord shall not recover more than one hundred percent ​ (100%) of the cost of such utilities. ​ ​ 28 ​ 16.2. Landlord shall not be liable for, nor shall any eviction of Tenant result from, the ​ failure to furnish any utility or service, whether or not such failure is caused by accidents; ​ breakage; casualties (to the extent not caused by the party claiming Force Majeure); Severe ​ Weather Conditions (as defined below); physical natural disasters (but excluding weather ​ conditions that are not Severe Weather Conditions); strikes, lockouts or other labor disturbances ​ or labor disputes (other than labor disturbances and labor disputes resulting solely from the acts ​ or omissions of the party claiming Force Majeure); acts of terrorism; riots or civil disturbances; ​ wars or insurrections; shortages of materials (which shortages are not unique to the party ​ claiming Force Majeure); government regulations, moratoria or other governmental actions, ​ inactions or delays; failures to grant consent or delays in granting consent by any Lender whose ​ consent is required under any applicable Loan Document; failures by third parties to deliver gas, ​ oil or another suitable fuel supply, or inability of the party claiming Force Majeure, by exercise ​ of reasonable diligence, to obtain gas, oil or another suitable fuel; or other causes beyond the ​ reasonable control of the party claiming that Force Majeure has occurred (collectively, “Force ​ Majeure”). In the event of such failure, Tenant shall not be entitled to termination of this Lease ​ or any abatement or reduction of Rent, nor shall Tenant be relieved from the operation ofany ​ covenant or agreement of this Lease. “Severe Weather Conditions” means weather conditions ​ that are materially worse than those that reasonably would be anticipated for the Property at the ​ applicable time based on historic meteorological records. Notwithstanding anything to the ​ contrary in this Lease, if, for more than ten (10) consecutive business days following written ​ notice to Landlord and as a direct result of Landlord’s gross negligence or willful misconduct ​ (and except to the extent that such failure is caused by any other factor, including any action or ​ inaction of a Tenant Party (as defined below)), the provision of HVAC (as defined below) or ​ other utilities to all or a material portion of the Premises that Landlord must provide pursuant to ​ this Lease is interrupted (a “Material Services Failure”), then Tenant’s Base Rent and Operating ​ Expenses (or, to the extent that less than all of the Premises are affected, a proportionate amount ​ (based on the Rentable Area of the Premises that is rendered unusable) of Base Rent and ​ Operating Expenses) shall thereafter be abated until the Premises are again usable by Tenant for ​ the Permitted Use; provided, however, that, if Landlord is diligently pursuing the restoration of ​ such HVAC and other utilities and Landlord provides substitute HVAC and other utilities ​ reasonably suitable for Tenant’s continued use and occupancy of the Premises for the Permitted ​ Use (e.g., supplying potable water or portable air conditioningequipment), then neither Base ​ Rent nor Operating Expenses shall be abated. Notwithstanding the foregoing, in the event that ​ Landlord fails to remedy a Material Services Failure within thirty (30) days after Landlord’s ​ receipt of notice of a Material Services Failure (or, if such repair or maintenance cannot ​ reasonably be completed within such period, within the period of time reasonably required (so ​ long as Landlord begins such repair or maintenance within such period and diligently prosecutes ​ the same to completion)), Tenant shall have the right to remedy such Material Services Failure ​ subject to the terms, conditions and provisions of Section 18.5 below. During any Material ​ Services Failure, Tenant will cooperate with Landlord to arrange for the provision of any ​ interrupted utility services on an interim basis via temporary measures until final corrective ​ measures can be accomplished, and Tenant will permit Landlord the necessary access to the ​ Premises to remedy such Material Service Failure. In the event of any interruption of HVAC or ​ other utilities that Landlord must provide pursuant to this Lease, regardless of the cause, ​ Landlord shall diligently pursue the restoration of such HVAC and other utilities. ​ Notwithstanding anything in this Lease to the contrary, but subject to Article 24 (which shall ​ ​ 29 ​ govern in the event of a casualty), the provisions of this Section shall be Tenant’s sole recourse ​ and remedy in the event of an interruption of HVAC or other utilities to the Premises. ​ ​ 16.3. Tenant shall pay for, prior to delinquency of payment therefor, any utilities and ​ services that may be furnished to the Premises during or, if Tenant occupies the Premises after ​ the expiration or earlier termination of the Term, after the Term, beyond those utilities provided ​ by Landlord, including telephone, internet service, cable television and other ​ telecommunications, together with any fees, surcharges and taxes thereon. Upon Landlord’s ​ demand, utilities and services provided to the Premises that are separately metered shall be paid ​ by Tenant directly to the supplier of such utilities or services. ​ ​ 16.4. Tenant shall not, without Landlord’s prior written consent, use any device in the ​ Premises (including data processing machines) that will in any way (a) increase the amount of ​ ventilation, air exchange, gas, steam, electricity or water required or consumed in the Premises ​ based upon Tenant’s Pro Rata Share of the Project beyond the existing capacity of the Project ​ usually furnished or supplied for the Permitted Use or (b) exceed Tenant’s Pro Rata Share of the ​ Project’s capacity to provide such utilities or services. ​ ​ 16.5. If Tenant shall require utilities or services in excess of those usually furnished or ​ supplied for tenants in similar spaces in the Building or the Project by reason ofTenant’s ​ equipment or extended hours of business operations, then Tenant shall first procure Landlord’s ​ consent for the use thereof, which consent Landlord may condition upon the availability of such ​ excess utilities or services, and Tenant shall pay as Additional Rent an amount equal to the cost ​ of providing such excess utilities and services. ​ ​ 16.6. Landlord shall provide water in Common Area for lavatory and landscaping ​ purposes only, which water shall be from the local municipal or similar source; provided, ​ however, that if Landlord determines that Tenant requires, uses or consumes water provided to ​ the Common Area for any purpose other than ordinary lavatory purposes, Landlord may install a ​ water meter (“Tenant Water Meter”) and thereby measure Tenant’s water consumption for all ​ purposes. Tenant shall pay Landlord for the costs of any Tenant Water Meter and the ​ installation and maintenance thereof during the Term. If Landlord installs a Tenant Water ​ Meter, Tenant shall pay for water consumed, as shown on such meter, as and when bills are ​ rendered. If Tenant fails to timely make such payments, Landlord may pay such charges and ​ collect the same from Tenant. Any such costs or expenses incurred or payments made by ​ Landlord for any of the reasons or purposes stated in this Section shall be deemed to be ​ Additional Rent payable by Tenant and collectible by Landlord as such. ​ ​ 16.7. Landlordreserves the right to stop service of the elevator, plumbing, ventilation, ​ air conditioning and utility systems, upon not less than two (2) business days’ prior notice to ​ Tenant, when Landlord deems necessary or desirable, due to accident, emergency or the need to ​ make repairs, alterations or improvements, until such repairs, alterations or improvements shall ​ have been completed, and Landlord shall further have no responsibility or liability for failure to ​ supply elevator facilities, plumbing, ventilation, air conditioning or utility service when ​ prevented from doing so by Force Majeure or, to the extent permitted by Applicable Laws, ​ Landlord’s negligence (except as provided in Section 16.2). Notwithstanding the foregoing, in ​ cases of emergency or due to accident, Landlord shall not be required to provide notice to ​ ​ 30 ​ Tenant. Without limiting the foregoing, it is expressly understood and agreed that any covenants ​ on Landlord’s part to furnish any service pursuant to any of the terms, covenants, conditions, ​ provisions or agreements of this Lease, or to perform any act or thing for the benefit of Tenant, ​ shall not be deemed breached if Landlord is unable to furnish or perform the same by virtue of ​ Force Majeure or, to the extent permitted by Applicable Laws, Landlord’s negligence (subject to ​ Section 16.2). Notwithstanding the foregoing, Landlord shall use commercially reasonable ​ efforts to schedule any maintenance and/or repair activities that are the responsibility of ​ Landlord under this Lease during times that will minimize interference with Tenant and its ​ business activities conducted from the Premises. ​ ​ 16.8. Tenant shall have the right to connect the existing back-up generator serving the ​ Building (the “Generator”) to the Premises’ emergency electrical panel. Tenant acknowledges ​ and agrees that Landlord has made no representation or warranty (express or implied) regarding ​ the condition of the Generator or the suitability of the Generator for Tenant's use, including any ​ warranty of merchantability or fitness for a particular purpose. The Generator shall be the sole ​ responsibility of Tenant and Landlord shall have no obligations with respect thereto. Tenant ​ shall, at its sole cost and expense, maintain and keep the Generator in good condition and repair, ​ incompliance with all Applicable Laws (including, without limitation, any required permits) and ​ shall otherwise be solely responsible for any repair, maintenance and/or replacement costs with ​ respect to the Generator. Tenant shall keep in full force and effect during the Term (and ​ occupancy by Tenant, if any, after termination of this Lease) a preventative maintenance contract ​ for inspections and maintenance for the Generator (using a qualified, licensed, bonded service ​ provider reasonably approved by Landlord) at commercially reasonable intervals that comply ​ with industry standard practices and Applicable Laws. If requested in writing by Landlord, ​ Tenant shall provide to Landlord copies of any Generator maintenance contracts and any ​ Generator maintenance reports on a quarterly basis. Notwithstanding anything to the contrary in ​ this Lease, Landlord shall have no liability, and Tenant shall have no right or remedy, on account ​ of any interruption or impairment with respect to the Generator or failure of the Generator to ​ operate in an emergency situation. ​ ​ 16.9. Tenant shall (a) maintain and operate the heating, ventilating and air conditioning ​ systems (including, without limitation, the exhaust fume hoods) exclusively serving the Premises ​ used for the Permitted Use only (“HVAC”) and (b) furnish HVAC as reasonably required for ​ reasonably comfortable occupancy of the Premises twenty-four (24) hours a day, every day ​ during the Term. Tenant shallkeep in full force and effect during the Term (and occupancy by ​ Tenant, if any, after termination of this Lease) a preventative maintenance contract for ​ inspections and maintenance using a qualified, licensed, bonded service provider reasonably ​ approved by Landlord at commercially reasonable intervals that comply with industry standard ​ practices and Applicable Laws. Notwithstanding anything to the contrary in this Section, ​ Landlord shall have no liability, and Tenant shall have no right or remedy, on account of any ​ interruption or impairment in HVAC services. If requested in writing by Landlord, Tenant shall ​ provide to Landlord copies of HVAC maintenance contracts and HVAC maintenance reports on ​ a quarterly basis. In the event Landlord determines that Tenant is not properly maintaining the ​ HVAC, Landlord may take over the responsibilities in (a) and (b) above. Any reasonable costs ​ or expenses incurred, or payments made by Landlord as a result of Tenant failing to properly ​ ​ 31 ​ maintain the HVAC, shall be deemed to be Additional Rent payable by Tenant and collectible by ​ Landlord as such. ​ ​ 16.10. For any utilities serving the Premises for which Tenant is billed directly by such ​ utility provider, Tenant agrees to furnish to Landlord (a) any invoices or statements for such ​ utilities within thirty (30) days after Landlord’s request therefor, (b) within thirty (30) days after ​ Landlord’s request, any other utility usage information reasonably requested by Landlord, and ​ (c) within thirty (30) days after each calendar year during the Term, authorization to allow ​ Landlord to access Tenant’s usage information necessary for Landlord to comply with ​ Applicable Law; and Tenant shall comply with any other energy usage or consumption ​ requirements required by Applicable Laws. Tenant shall retain records of utility usage at the ​ Premises, including invoices and statements from the utility provider, for at least thirty-six (36) ​ months, or such longer period of time as may be required by Applicable Law. Tenant ​ acknowledges that any utility information for the Premises, the Building and the Project may be ​ shared with third parties, including Landlord’s consultants and Governmental Authorities. In the ​ event that Tenant fails to comply with this Section, Tenant hereby authorizes Landlord to collect ​ utility usage information directly from the applicable utility providers. In addition to the ​ foregoing, Tenant shall comply with all Applicable Laws related to the disclosure and tracking ​ ofenergy consumption at the Premises. The provisions of this Section shall survive the ​ expiration or earlier termination of this Lease. ​ ​ 17. Alterations. ​ 17.1. Except for Cosmetic Alterations (as defined below), Tenant shall make no ​ alterations, additions or improvements (other than the Tenant Improvements) in or to the ​ Premises or engage in any construction, demolition, reconstruction, renovation or other work ​ (whether major or minor) of any kind in, at or serving the Premises (“Alterations”) without ​ Landlord’s prior written approval, which approval may be subject to the consent of one or more ​ Lenders, if required under any applicable Loan Document, but which approval Landlord shall ​ not otherwise unreasonably withhold, condition or delay; provided, however, that, in the event ​ any proposed Alteration affects (a) any structural portions of the Building, including exterior ​ walls, the roof, the foundation or slab, foundation or slab systems (including barriers and subslab ​ systems) or the core of the Building, (b) the exterior of the Building or (c) any Building systems, ​ including elevator, plumbing, HVAC, electrical, security, life safety and power, then Landlord ​ may withhold its approval in its sole and absolute discretion. Tenant shall, in making any ​ Alterations, use only those architects, contractors, suppliers and mechanics of which Landlord ​ has given prior written approval, which approval shall be in Landlord’s sole and absolute ​ discretion. In seeking Landlord’s approval, Tenant shallprovide Landlord, at least sixty (60) ​ days in advance of the desired commencement date of any proposed construction, with plans, ​ specifications, bid proposals, certified stamped engineering drawings and calculations by ​ Tenant’s engineer of record or architect of record (including connections to the Building’s ​ structural system, modifications to the Building’s envelope, non-structural penetrations in slabs ​ or walls, and modifications or tie-ins to life safety systems), work contracts, requests for ​ laydown areas and such other information concerning the nature and cost of the Alterations as ​ Landlord may reasonably request, provided that Tenant shall not commence any such Alterations ​ that require Landlord’s consent unless and until Tenant has received the written approval of ​ Landlord and any and all Lenders whose consent is required under any applicable Loan ​ ​ 32 ​ Document. In no event shall Tenant use or Landlord be required to approve any architects, ​ consultants, contractors, subcontractors or material suppliers that Landlord reasonably believes ​ could cause labor disharmony or may not have sufficient experience, in Landlord’s reasonable ​ opinion, to perform work in an occupied Class “A” laboratory research building and in lab areas. ​ Notwithstanding the foregoing, Tenant may make strictly cosmetic changes to the Premises that ​ do not require any permits or more than three (3) total contractors and subcontractors (“Cosmetic ​ Alterations”) without Landlord’s consent; provided that (y) the cost of any Cosmetic Alterations ​ does not exceed Five Hundred Thousand Dollars ($500,000) annually, (z) such Cosmetic ​ Alterations are not reasonably expected to have any material adverse effect on the Project and do ​ not (i) require any structural or other substantial modifications to the Premises, (ii) require any ​ changes to or adversely affect the Building systems, (iii) affect any portion of the Building or ​ Project that is exterior to the Premises, or (iv) trigger any requirement under Applicable Laws ​ that would require Landlord to make any alteration or improvement to the Premises, the Building ​ or the Project. Tenant shall not be required to give Landlord prior written notice of any ​ Cosmetic Alterations, unless such Cosmetic Alterations will generate noise or other disruption ​ outside of the Building. ​ ​ 17.2. Tenant shall not construct or permitto be constructed partitions or other ​ obstructions that might interfere with free access to mechanical installation or service facilities ​ of the Building or with other tenants’ components located within the Building (in the event ​ Tenant does not lease the entire Building), or interfere with the moving of Landlord’s equipment ​ to or from the enclosures containing such installations or facilities. ​ ​ 17.3. Tenant shall accomplish any work performed on the Premises or the Building in ​ such a manner as to permit any life safety systems to remain fully operable at all times. ​ ​ 17.4. Any work performed on the Premises, the Building or the Project by Tenant or ​ Tenant’s contractors which could generate noise or other disruption outside of the Building shall ​ be done at such times and in such manner as Landlord may from time to time designate. Tenant ​ covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in ​ full compliance with Applicable Laws. Within thirty (30) days after completion of any ​ Alterations, Tenant shall provide Landlord with complete “as built” drawing print sets and ​ electronic CADD files on disc (or files in such other current format in common use as Landlord ​ reasonably approves or requires) showing any changes in the Premises, as well as a ​ commissioning report prepared by a licensed, qualified commissioning agent hired by Tenant ​ and approved by Landlord for all new or affected mechanical, electrical and plumbing systems. ​ Anysuch “as built” plans shall show the applicable Alterations as an overlay on the Building as- ​ built plans; provided that Landlord provides the Building “as built” plans to Tenant. ​ ​ 17.5. Before commencing any Alterations or Tenant Improvements (other than ​ Cosmetic Alterations), Tenant shall (a) give Landlord at least sixty (60) days’ prior written ​ notice of the proposed commencement of such work and the names and addresses of the persons ​ supply labor or materials therefor so that Landlord may enter the Premises to post and keep ​ posted thereon and therein notices or to take any further action that Landlord may reasonably ​ deem proper for the protection of Landlord’s interest in the Project and (b) shall, if required by ​ ​ 33 ​ Landlord, secure, at Tenant’s own cost and expense, a completion and lien indemnity bond ​ satisfactory to Landlord for any work costing in excess of Fifty Thousand Dollars ($50,000). ​ ​ 17.6. Tenant shall repair any damage to the Premises caused by Tenant’s removal of ​ any property from the Premises. During any such restoration period, Tenant shall pay Rent to ​ Landlord as provided herein as if such space were otherwise occupied by Tenant. The ​ provisions of this Section shall survive the expiration or earlier termination of this Lease. ​ ​ 17.7. The Premises plus any Alterations; Signage; Tenant Improvements; attached ​ equipment, decorations, fixtures and trade fixtures; movable laboratory casework and related ​ appliances; and other additions and improvements attached to or built into the Premises made by ​ either of the parties (including all floor and wall coverings; paneling; sinks; fixed laboratory ​ benches; exterior venting fume hoods; walk-in freezers and refrigerators; ductwork; conduits; ​ electrical panels and circuits; attached machinery and equipment; and built-in furniture and ​ cabinets, in each case, together with all additions and accessories thereto), shall (unless, prior to ​ such construction or installation, Landlord elects otherwise in writing) at all times remain the ​ property of Landlord, shall remain in the Premises and shall (unless, prior to construction or ​ installation thereof, Landlord elects otherwise in writing) be surrendered to Landlordupon the ​ expiration or earlier termination of this Lease. For the avoidance of doubt, the items listed on ​ Exhibit H attached hereto (which Exhibit H may be updated by Tenant from and after the Term ​ Commencement Date, subject to Landlord’s written consent) constitute Tenant’s property and ​ shall be removed by Tenant upon the expiration or earlier termination of the Lease. ​ ​ 17.8. Notwithstanding any other provision of this Article to the contrary, in no event ​ shall Tenant remove any improvement from the Premises in which any Lender has a security ​ interest or as to which Landlord contributed payment, including the Tenant Improvements, ​ without Landlord’s prior written consent, which consent Landlord may withhold in its sole and ​ absolute discretion. ​ ​ 17.9. If Tenant shall fail to remove any of its property from the Premises prior to the ​ expiration or earlier termination of this Lease, then Landlord may, at its option, remove the same ​ in any manner that Landlord shall choose and store such effects without liability to Tenant for ​ loss thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any costs and ​ expenses incurred due to such removal and storage or Landlord may, at its sole option and ​ without notice to Tenant, sell such property or any portion thereof at private sale and without ​ legal process for such price as Landlord may obtain and apply the proceeds of such sale against ​ any (a) amounts due by Tenant to Landlord under thisLease and (b) any expenses incident to the ​ removal, storage and sale of such personal property. ​ ​ 17.10. Tenant shall pay to Landlord an amount equal to two percent (2%) of the cost to ​ Tenant of all Alterations (excluding Cosmetic Alterations) to cover Landlord’s overhead and ​ expenses for plan review, engineering review, coordination, scheduling and supervision thereof ​ or obtaining any required Lender consent. For purposes of payment of such sum, Tenant shall ​ submit to Landlord copies of all bills, invoices and statements covering the costs of such ​ charges, accompanied by payment to Landlord of the fee set forth in this Section. Tenant shall ​ reimburse Landlord for any extra expenses incurred by Landlord by reason of faulty work done ​ ​ ​ by Tenant or its contractors, or by reason of delays caused by such work, or by reason of ​ inadequate clean-up. ​ ​ 17.11. Within sixty (60) days after final completion of the Tenant Improvements or any ​ Alterations performed by Tenant with respect to the Premises, Tenant shall submit to Landlord ​ documentation showing the amounts expended by Tenant with respect to such Tenant ​ Improvements and Alterations, together with supporting documentation reasonably acceptable to ​ Landlord. ​ ​ 17.12. Tenant shall take, and shall cause its contractors to take, commercially reasonable ​ steps to protect the Premises during the performance of any Alterations or Tenant Improvements, ​ including covering or temporarily removing any window coverings so as to guard against dust, ​ debris or damage. ​ ​ 17.13. Tenant shall require its contractors and subcontractors performing work on the ​ Premises to name Landlord and its affiliates and Lenders as additional insureds on their ​ respective insurance policies. ​ ​ 18. Repairs and Maintenance. ​ 18.1. Landlord’s Repair and Maintenance. Landlord shall repair and maintain in good ​ condition the structural and exterior portions of the Building and the Common Area of the ​ Project, including roofing and covering materials; foundations (excluding any architectural slabs, ​ but including any structural slabs); and exterior walls. ​ ​ 18.2. Tenant’s Repair and Maintenance. Except for services of Landlord, if any, ​ requiredby Section 18.1, Tenant shall at Tenant’s sole cost and expense maintain and keep the ​ Premises and every part thereof (including, without limitation, all Building systems) in good ​ condition and repair, damage thereto from ordinary wear and tear excepted, and shall, within ten ​ (10) business days after receipt of written notice from Landlord, provide to Landlord any ​ maintenance records that Landlord reasonably requests. Without limiting the generality of the ​ foregoing, Tenant shall, at Tenant’s sole cost and expense, (a) maintain the HVAC in accordance ​ with all of the terms, conditions, provisions and agreements set forth in Section 16.9 above, and ​ (b) hire (i) a licensed elevator contractor to regularly and periodically (at commercially ​ reasonable intervals that comply with industry standard practices and Applicable Laws) inspect ​ and perform required maintenance on the elevator(s) serving the Premises, (ii) a licensed fire ​ alarm contractor to regularly and periodically (at commercially reasonable intervals that comply ​ with industry standard practices and Applicable Laws) inspect and perform required ​ maintenance on the fire alarm equipment and systems serving the Premises, (iii) a licensed ​ sprinkler inspection contractor to regularly and periodically (at commercially reasonable ​ intervals that comply with industry standard practices and Applicable Laws) inspect and perform ​ required maintenance on the sprinkler equipment and systems serving thePremises, (iv) a ​ backflow inspection contractor to regularly and periodically (at commercially reasonable ​ intervals that comply with industry standard practices and Applicable Laws) inspect and perform ​ required maintenance on the backflow equipment and systems serving the Premises, (v) a ​ licensed BMS contractor to regularly and periodically (at commercially reasonable intervals that ​ comply with industry standard practices and Applicable Laws) inspect and perform required ​ ​ 34 ​ ​ ​ maintenance on the BMS equipment and systems serving the Premises, (vi) a licensed chemical ​ water treatment contractor to regularly and periodically (at commercially reasonable intervals ​ that comply with industry standard practices and Applicable Laws) inspect and perform required ​ maintenance on the chemical water treatment equipment and systems serving the Premises, (vii) ​ a licensed pure water treatment contractor to regularly and periodically (at commercially ​ reasonable intervals that comply with industry standard practices and Applicable Laws) inspect ​ and perform required maintenance on the pure water treatment equipment and systems serving ​ the Premises, (viii) an air compressor and vacuum pump contractor to regularly and periodically ​ (at commercially reasonable intervals that comply with industry standard practices and ​ Applicable Laws) inspect and perform required maintenance on the air compressor and vacuum ​ pump equipment and systems serving the Premises, and (ix) a licensed electrical maintenance ​ contractor to regularly and periodically (at commercially reasonable intervals that comply with ​ industry standard practices and Applicable Laws) inspect and perform required maintenance on ​ the electrical equipment and systems serving the Premises. ​ ​ 18.3. Notwithstanding anything to the contrary, if Tenant shall fail, after twenty (20) ​ days’ written notice, to (a) hire the contractors (or cause such contractors to performthe ​ inspections and maintenance) required under Section 18.2 above or (b) perform any maintenance ​ or to make, or to commence and thereafter to proceed with diligence to make, any repair required ​ of it with respect to the Premises pursuant to the terms of the Lease, Landlord, without being ​ under any obligation to do so and without thereby waiving such default by Tenant, may hire such ​ contractors, perform such maintenance or make such repair and may charge Tenant for the ​ reasonable costs thereof. Any expense reasonably incurred by Landlord in connection therewith ​ may be billed by Landlord to Tenant monthly or, at Landlord’s option, immediately, and shall be ​ due and payable within thirty (30) days after such billing or, at Landlord’s option, may be ​ deducted from the Security Deposit. ​ ​ 18.4. Tenant shall, upon the expiration or sooner termination of the Term, surrender the ​ Premises to Landlord in as good a condition as when received, ordinary wear and tear excepted ​ and with the Tenant Improvements in substantially the same condition as existed on the Term ​ Commencement Date, ordinary wear and tear excepted; and shall, at Landlord’s request and ​ Tenant’s sole cost and expense, remove all telephone and data systems, wiring and equipment ​ from the Premises, and repair any damage to the Premises caused thereby. Landlord shall have ​ no obligation to alter, remodel, improve, repair, decorate or paint the Premises. ​ ​18.5. Landlord shall not be liable for any failure to make any repairs or to perform any ​ maintenance that is Landlord’s obligation pursuant to this Lease unless such failure shall persist ​ for an unreasonable time after Tenant provides Landlord with written notice of the need of such ​ repairs or maintenance. Tenant waives its rights under Applicable Laws now or hereafter in ​ effect to make repairs at Landlord’s expense. Notwithstanding the foregoing, in the event that ​ Landlord timely fails to make a repair or perform maintenance that is Landlord's obligation ​ pursuant to this Lease, Tenant may notify Landlord of such failure and, if Landlord does not ​ make the repair or perform the maintenance within thirty (30) days after Landlord's receipt of ​ such notice (or, if such repair or maintenance cannot reasonably be completed within such ​ period, within the period of time reasonably required (so long as Landlord begins the repair or ​ maintenance within such period and diligently prosecutes the same to completion)), Tenant may ​ ​ 35 ​ ​ ​ perform the repair or maintenance and Landlord shall reimburse Tenant for its reasonable out-of- ​ pocket costs for performing the same within thirty (30) days after receipt of an invoice from ​ Tenant therefor. Notwithstanding anything in this Section to the contrary, before performing any ​ such repairs or maintenance, Tenant shall notify Landlord of Tenant's intent to do so and shall ​ reasonably coordinate with Landlord and any other tenants of the Project that may be affected ​ the need for such repairs or maintenance. ​ ​ 18.6. If any excavation shall be made upon land adjacent to or under the Building, or ​ shall be authorized to be made, Tenant shall afford to the person causing or authorized to cause ​ such excavation, license to enter the Premises for the purpose of performing such work as such ​ person shall reasonably deem necessary or desirable to preserve and protect the Building from ​ injury or damage and to support the same by proper foundations, without any claim for damages ​ or liability against Landlord and without reducing or otherwise affecting Tenant’s obligations ​ under this Lease. In connection with the foregoing, Landlord shall work with Tenant to the ​ extent commercially reasonable to ensure Tenant’s quiet enjoyment of the Premises are not ​ disrupted during work hours. ​ ​ 18.7. This Article relates to repairs and maintenance arising in the ordinary course of ​ operation of the Building and the Project. In the event of a casualty described in Article24, ​ Article 24 shall apply in lieu of this Article. In the event of eminent domain, Article 25 shall ​ apply in lieu of this Article. ​ ​ 18.8. Costs incurred by Landlord pursuant to this Article shall constitute Operating ​ Expenses to the extent that such costs may properly be included in Operating Expenses under ​ Article 9 of this Lease. ​ ​ 19. Liens. ​ 19.1. ​ ​ Subject to the immediately succeeding sentence, Tenant shall keep the Premises, ​ the Building and the Project free from any liens arising out of work or services performed, ​ materials furnished to or obligations incurred by Tenant. Tenant further covenants and agrees ​ that any mechanic’s or materialman’s lien filed against the Premises, the Building or the Project ​ for work or services claimed to have been done for, or materials claimed to have been furnished ​ to, or obligations incurred by Tenant shall be discharged or bonded by Tenant within twenty (20) ​ days after the filing thereof, at Tenant’s sole cost and expense. ​ ​ 19.2. Should Tenant fail to discharge or bond against any lien of the nature described in ​ Section 19.1, Landlord may, at Landlord’s election, pay such claim or post a statutory lien bond ​ or otherwise provide security to eliminate the lien as a claim against title, and Tenant shall ​ immediately reimburse Landlord for the costs thereof as Additional Rent. Tenant shall ​ Indemnify the Landlord Indemnitees from and against any Claims arising from any such liens, ​ including any administrative, court or other legal proceedingsrelated to such liens. ​ ​ 19.3. In the event that Tenant leases or finances the acquisition of office equipment, ​ furnishings or other personal property of a removable nature utilized by Tenant in the operation ​ of Tenant’s business, Tenant warrants that any Uniform Commercial Code financing statement ​ shall, upon its face or by exhibit thereto, indicate that such financing statement is applicable only ​ ​ 36 ​ ​ ​ to removable personal property of Tenant located within the Premises. In no event shall the ​ address of the Premises, the Building or the Project be furnished on a financing statement ​ without qualifying language as to applicability of the lien only to removable personal property ​ located in an identified suite leased by Tenant. Should any holder of a financing statement ​ record or place of record a financing statement that appears to constitute a lien against any ​ interest of Landlord or against equipment that may be located other than within an identified ​ suite leased by Tenant, Tenant shall, within ten (10) days after filing such financing statement, ​ cause (a) a copy of the lender security agreement or other documents to which the financing ​ statement pertains to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that ​ the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s ​ lender to amend such financing statement and any other documents of record to clarify that any ​ liens imposed thereby are not applicable to any interest of Landlord in the Premises, the Building ​ or the Project. ​ ​ 20. Estoppel Certificate. Tenant shall, within ten (10) business days after receipt of written ​ notice from Landlord, execute, acknowledge and deliver a statement in writing substantially in ​ the form attached to this Lease as Exhibit I, or on any other form reasonably requested by a ​ current or proposed Lender or encumbrancer or proposedpurchaser, (a) certifying that this Lease ​ is unmodified and in full force and effect (or, if modified, stating the nature of such modification ​ and certifying that this Lease as so modified is in full force and effect) and the dates to which ​ rental and other charges are paid in advance, if any, (b) acknowledging that there are not, to ​ Tenant’s knowledge, any uncured defaults on the part of Landlord hereunder, or specifying such ​ defaults if any are claimed, and (c) setting forth such further information with respect to this ​ Lease or the Premises as may be requested thereon. Any such statements may be relied upon by ​ any prospective purchaser or encumbrancer of all or any portion of the Property. Tenant’s ​ failure to deliver any such statement within the prescribed time shall, at Landlord’s option, ​ constitute a Default (as defined below) under this Lease (after an additional written notice sent in ​ accordance with Section 39 with a copy of such notice e-mailed to the e-mail address set forth in ​ Section 2.10, and the expiration of an additional five (5) day cure period), and, in any event, ​ shall be binding upon Tenant that the Lease is in full force and effect and without modification ​ except as may be represented by Landlord in any certificate prepared by Landlord and delivered ​ to Tenant for execution. ​ ​ 21. Hazardous Materials. ​ 21.1. Tenant shall not cause or permit any Hazardous Materials (as defined below) to ​ be brought upon, kept or used in or about the Premises, the Building or theProject in violation of ​ Applicable Laws by Tenant or any of its employees, agents, contractors or invitees (collectively ​ with Tenant, each a “Tenant Party”). If (a) Tenant breaches such obligation, (b) the presence of ​ Hazardous Materials as a result of such a breach results in contamination of the Project, any ​ portion thereof, or any adjacent property, (c) contamination of the Premises otherwise occurs ​ during the Term or any extension or renewal hereof or holding over hereunder (other than if such ​ contamination results from (i) migration of Hazardous Materials from outside the Premises not ​ caused by a Tenant Party or (ii) to the extent such contamination is caused by Landlord's gross ​ negligence or willful misconduct) or (d) contamination of the Project occurs as a result of ​ Hazardous Materials that are placed on or under or are released into the Project by a Tenant ​ Party, then Tenant shall Indemnify the Landlord Indemnitees from and against any and all ​ 37 ​ ​ ​ Claims of any kind or nature, including (w) diminution in value of the Project or any portion ​ thereof, (x) damages for the loss or restriction on use of rentable or usable space or of any ​ amenity of the Project, (y) damages arising from any adverse impact on marketing of space in ​ the Project or any portion thereof and (z) sums paid in settlement of Claims that arise before, ​ during or after the Term as a result of such breach or contamination. This Indemnification by ​ Tenant includes costs incurred in connection with any investigation of site conditions or any ​ clean-up, remedial, removal or restoration work required by any Governmental Authority ​ because of Hazardous Materials present in the air, soil or groundwater above, on, under or about ​ the Project. Without limiting the foregoing, if the presence of any Hazardous Materials in, on, ​ under or about the Project, any portion thereof or any adjacent property caused or permitted by ​ any Tenant Party results in any contamination of the Project, any portion thereof or any adjacent ​ property, then Tenant shall promptly take all actions at its sole cost and expense as are necessary ​ to return the Project, any portion thereof or any adjacent property to its respective condition ​ existing prior to the time of such contamination; provided that Landlord’s written approval of ​ such action shall first be obtained, which approval Landlord shall not unreasonably withhold; ​ and provided, further, that it shall be reasonable for Landlord to withhold its consent if such ​actions could have a material adverse long-term or short-term effect on the Project, any portion ​ thereof or any adjacent property. Tenant’s obligations under this Section shall not be affected, ​ reduced or limited by any limitation on the amount or type of damages, compensation or benefits ​ payable by or for Tenant under workers’ compensation acts, disability benefit acts, employee ​ benefit acts or similar legislation. Notwithstanding the foregoing, Landlord shall (a) indemnify, ​ save, defend (at Tenant’s option and with counsel reasonably acceptable to Tenant) and hold the ​ Tenant Parties harmless from and against any and all Claims resulting from the presence of ​ Hazardous Materials at the Project in violation of Applicable Laws as of the Execution Date, ​ unless placed at the Project by a Tenant Party, and (b) reimburse Tenant for any out-of-pocket ​ costs incurred by Tenant (and approved in advance by Landlord) to remediate Hazardous ​ Materials at the Project in violation of Applicable Laws as of the Execution Date, unless such ​ Hazardous Materials were placed at the Project by a Tenant Party. ​ ​ 21.2. Landlord acknowledges that it is not the intent of this Article to prohibit Tenant ​ from operating its business for the Permitted Use. Tenant may operate its business according to ​ the custom of Tenant’s industry so long as the use or presence of Hazardous Materials is strictly ​ and properly monitored in accordance with Applicable Laws. As a materialinducement to ​ Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant ​ agrees to deliver to Landlord (and any Lender of Landlord) (a) a list identifying each type of ​ Hazardous Material to be present at the Premises that is subject to regulation under any ​ environmental Applicable Laws in the form of a Tier II form pursuant to Section 312 of the ​ Emergency Planning and Community Right-to-Know Act of 1986 (or any successor statute) or ​ any other form reasonably requested by Landlord, (b) a list of any and all approvals or permits ​ from Governmental Authorities required in connection with the presence of such Hazardous ​ Material at the Premises and (c) correct and complete copies of (i) notices of violations of ​ Applicable Laws related to Hazardous Materials and (ii) plans relating to the installation of any ​ storage tanks to be installed in, on, under or about the Project (provided that installation of ​ storage tanks shall only be permitted after Landlord has given Tenant its written consent to do ​ so, which consent Landlord may withhold in its sole and absolute discretion) and closure plans ​ or any other documents required by any and all Governmental Authorities for any storage tanks ​ ​ 38 ​ ​ ​ installed in, on, under or about the Project for the closure of any such storage tanks (collectively, ​ “Hazardous Materials Documents”). Tenant shall deliver to Landlord (and any Lender of ​ Landlord) updated Hazardous Materials Documents, within fourteen (14) days after receipt of a ​ written request therefor from Landlord, not more often than once per year, unless (m) there are ​ any changes to the Hazardous Materials Documents or (n) Tenant initiates any Alterations or ​ changes its business, in either case in a way that involves any material increase in the types or ​ amounts of Hazardous Materials, in which case Tenant shall deliver updated Hazardous ​ Materials documents (without Landlord having to request them) before or, if not practicable to ​ do so before, as soon as reasonably practicable after the occurrence of the events in Subsection ​ 21.2(m) or (n). For each type of Hazardous Material listed, the Hazardous Materials Documents ​ shall include (t) the chemical name, (u) the material state (e.g., solid, liquid, gas or cryogen), (v) ​ the concentration, (w) the storage amount and storage condition (e.g., in cabinets or not in ​ cabinets), (x) the use amount and use condition (e.g., open use or closed use), (y) the location ​ (e.g., room number or other identification) and (z) if known, the chemical abstract service ​ number. Notwithstanding anything in this Section to the contrary, Tenant shall not be required ​ to provide Landlord with any documents containing information of a proprietarynature, unless ​ such documents contain a reference to Hazardous Materials or activities related to Hazardous ​ Materials. Landlord may, at Landlord’s expense, cause the Hazardous Materials Documents to ​ be reviewed by a person or firm qualified to analyze Hazardous Materials to confirm compliance ​ with the provisions of this Lease and with Applicable Laws. In the event that a review of the ​ Hazardous Materials Documents indicates non-compliance with this Lease or Applicable Laws, ​ Tenant shall, at its expense, diligently take steps to bring its storage and use of Hazardous ​ Materials into compliance. Notwithstanding anything in this Lease to the contrary or Landlord’s ​ review into Tenant’s Hazardous Materials Documents or use or disposal of hazardous materials, ​ however, Landlord shall not have and expressly disclaims any liability related to Tenant’s or ​ other tenants’ use or disposal of Hazardous Materials, it being acknowledged by Tenant that ​ Tenant is best suited to evaluate the safety and efficacy of its Hazardous Materials usage and ​ procedures. ​ ​ 21.3. Tenant represents and warrants to Landlord that as of the date of this Lease, ​ Tenant is not nor has it been, in connection with the use, disposal or storage of Hazardous ​ Materials, (a) subject to a material enforcement order issued by any Governmental Authority or ​ (b) required to take any remedial action. ​ ​ 21.4. At any time, and from time to time, prior to the expiration of the Term,Landlord ​ shall have the right to conduct appropriate tests of the Project or any portion thereof to ​ demonstrate that Hazardous Materials are present or that contamination has occurred due to the ​ acts or omissions of a Tenant Party. Tenant shall pay all reasonable documented costs of such ​ tests if such tests reveal that Hazardous Materials exist at the Project in violation of this Lease. ​ ​ 21.5. If underground or other storage tanks storing Hazardous Materials installed or ​ utilized by Tenant are located on the Premises, or are hereafter placed on the Premises by Tenant ​ (or by any other party, if such storage tanks are utilized by Tenant), then Tenant shall monitor ​ the storage tanks, maintain appropriate records, implement reporting procedures, properly close ​ any underground storage tanks, and take or cause to be taken all other steps required under the ​ Applicable Laws. Tenant shall have no responsibility or liability for underground or other ​ ​ 39 ​ ​ ​ storage tanks installed by anyone other than Tenant unless Tenant utilizes such tanks, in which ​ case Tenant’s responsibility for such tanks shall be as set forth in this Section. ​ ​ 21.6. Tenant shall promptly report to Landlord any actual or suspected presence of ​ mold or water intrusion at the Premises. ​ ​ 21.7. Tenant’s obligations under this Article shall survive the expiration or earlier ​ termination of the Lease. During any period of time needed by Tenant or Landlord after the ​ termination of this Lease to complete the removal from the Premises of any such Hazardous ​ Materials, Tenant shall be deemed a holdover tenant and subject to the provisions of Article 27. ​ ​ 21.8. As used herein, the term “Hazardous Material” means any toxic, explosive, ​ corrosive, flammable, infectious, radioactive, carcinogenic, mutagenic or otherwise hazardous ​ substance, material or waste that is or becomes regulated by Applicable Laws or any ​ Governmental Authority. ​ ​ 21.9. Notwithstanding anything to the contrary in this Lease, Landlord shall have sole ​ control over the equitable allocation of fire control areas (as defined in the Uniform Building ​ Code as adopted by the city or municipality(ies) in which the Project is located (the “UBC”)) ​ within the Project for the storage of Hazardous Materials. Notwithstanding anything to the ​ contrary in this Lease, the quantity of Hazardous Materials allowed by this Section is specific to ​ Tenant and shall not run with the Lease in the event of a Transfer (asdefined in Article 29). In ​ the event of a Transfer, if the use of Hazardous Materials by such new tenant (“New Tenant”) is ​ such that New Tenant utilizes fire control areas in the Project in excess of New Tenant’s Pro ​ Rata Share of the Project, then New Tenant shall, at its sole cost and expense and upon ​ Landlord’s written request, establish and maintain a separate area of the Premises classified by ​ the UBC as an “H” occupancy area for the use and storage of Hazardous Materials, or take such ​ other action as is necessary to ensure that its share of the fire control areas of Project is not ​ greater than New Tenant’s Pro Rata Share of the Project. Notwithstanding anything in this ​ Lease to the contrary, Landlord shall not have and expressly disclaims any liability related to ​ Tenant’s or other tenants’ use or disposal of fire control areas, it being acknowledged by Tenant ​ that Tenant and other tenants are best suited to evaluate the safety and efficacy of its Hazardous ​ Materials usage and procedures. ​ ​ 22. Odors and Exhaust. Tenant acknowledges that Landlord would not enter into this Lease ​ with Tenant unless Tenant assured Landlord that under no circumstances will any other ​ occupants of the Building or the Project (including persons legally present in any outdoor areas ​ of the Project) be subjected to odors or fumes (whether or not noxious), and that the Building ​ and the Project will not be damaged by any exhaust, in each case from Tenant’soperations. ​ Landlord and Tenant therefore agree as follows: ​ ​ 22.1. Tenant shall not cause or permit (or conduct any activities that would cause) any ​ release of any odors or fumes of any kind from the Premises. ​ ​ 22.2. If the Building has a ventilation system that, in Landlord’s judgment, is adequate, ​ suitable, and appropriate to vent the Premises in a manner that does not release odors affecting ​ any indoor or outdoor part of the Project, Tenant shall vent the Premises through such system. If ​ 40 ​ ​ ​ Landlord at any time reasonably determines that any existing ventilation system is inadequate, or ​ if no ventilation system exists, Tenant shall in compliance with Applicable Laws vent all fumes ​ and odors from the Premises (and remove odors from Tenant’s exhaust stream) as Landlord ​ reasonably requires. The placement and configuration of all ventilation exhaust pipes, louvers ​ and other equipment shall be subject to Landlord’s reasonable approval. Tenant acknowledges ​ Landlord’s legitimate desire to maintain the Project (indoor and outdoor areas) in an odor-free ​ manner, and Landlord may require Tenant to abate and remove all odors in a manner that goes ​ beyond the requirements of Applicable Laws. ​ ​ 22.3. Tenant shall, at Tenant’s sole cost and expense, provide odor eliminators and ​ other devices (such as filters, air cleaners, scrubbers and whatever other equipment may in ​ Landlord’s reasonable judgment be necessary or appropriate from time to time) to completely ​ remove, eliminate and abate any odors, fumes or other substances in Tenant’s exhaust stream ​ that, in Landlord’s reasonable judgment, emanate from Tenant’s Premises. Any work Tenant ​ performs under this Section shall constitute Alterations. ​ ​ 22.4. Tenant’s responsibility to remove, eliminate and abate odors, fumes and exhaust ​ shall continue throughout the Term. Landlord’s approval of the Tenant Improvements shall not ​ preclude Landlord fromrequiring additional measures to eliminate odors, fumes and other ​ adverse impacts of Tenant’s exhaust stream (as Landlord may designate in Landlord’s ​ reasonable discretion). Tenant shall install additional equipment as Landlord reasonably ​ requires from time to time under the preceding sentence. Such installations shall constitute ​ Alterations. ​ ​ 22.5. If Tenant fails to install satisfactory odor control equipment within ten (10) ​ business days after Landlord’s demand made at any time, then Landlord may, without limiting ​ Landlord’s other rights and remedies, require Tenant to cease and suspend any operations in the ​ Premises that, in Landlord’s reasonable determination, cause odors, fumes or exhaust. For ​ example, if Landlord determines that Tenant’s production of a certain type of product causes ​ odors, fumes or exhaust, and Tenant does not install satisfactory odor control equipment within ​ ten (10) business days after Landlord’s request, then Landlord may require Tenant to stop ​ producing such type of product in the Premises unless and until Tenant has installed odor control ​ equipment satisfactory to Landlord. ​ ​ 23. Insurance; Waiver of Subrogation. ​ 23.1. Landlord shall maintain insurance for the Building and the Project in amounts ​ equal to full replacement cost (exclusive of the costs of excavation, foundations and footings, ​ engineering costs or such other costs to the extent the same are not incurred in the event of a ​ rebuild andwithout reference to depreciation taken by Landlord upon its books or tax returns), ​ provided that such coverage shall not be less than the amount of such insurance Landlord’s ​ Lender, if any, requires Landlord to maintain, providing protection against any peril generally ​ included within the classification “Fire and Extended Coverage,” together with insurance against ​ sprinkler damage (if applicable), vandalism and malicious mischief. Landlord, subject to ​ availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, ​ environmental hazard, earthquake, loss or failure of building equipment, rental loss during the ​ period of repairs or rebuilding, Workers’ Compensation insurance and fidelity bonds for ​ ​ 41 ​ ​ ​ employees employed to perform services. Notwithstanding the foregoing, Landlord may, but ​ shall not be deemed required to, provide insurance for any improvements installed by Tenant or ​ that are in addition to the standard improvements customarily furnished by Landlord, without ​ regard to whether or not such are made a part of or are affixed to the Building. ​ ​ 23.2. In addition, Landlord shall carry Commercial General Liability insurance with ​ limits of not less than One Million Dollars ($1,000,000) per occurrence/general aggregate for ​ bodily injury (including death), or property damage with respect to the Project. ​ ​ 23.3. Tenant shall, at its own cost and expense, procure and maintain during the Term ​ the following insurance for the benefit of Tenant and Landlord (as their interests may appear) ​ with insurers financially acceptable and lawfully authorized to do business in the state where the ​ Premises are located: ​ ​ (a) Commercial General Liability insurance on a broad-based occurrence ​ coverage form, with coverages including but not limited to bodily injury (including death), ​ property damage (including loss of use resulting therefrom), premises/operations, personal & ​ advertising injury, and contractual liability with limits of liability of not less than $2,000,000 for ​ bodily injury and property damage per occurrence, $2,000,000 general aggregate, which limits ​ may be met by use of excess and/or umbrella liability insurance provided that such coverage is at ​ least as broad as theprimary coverages required herein. ​ ​ (b) Commercial Automobile Liability insurance covering liability arising from ​ the use or operation of any auto, including those owned, hired or otherwise operated or used by or ​ on behalf of the Tenant. The coverage shall be on a broad-based occurrence form with combined ​ single limits of not less than $1,000,000 per accident for bodily injury and property damage. ​ ​ (c) Commercial Property insurance covering property damage to the full ​ replacement cost value and business interruption. Covered property shall include all tenant ​ improvements in the Premises (to the extent not insured by Landlord pursuant to Section 23.1) ​ and Tenant’s Property including personal property, furniture, fixtures, machinery, equipment, ​ stock, inventory and improvements and betterments, which may be owned by Tenant or ​ Landlord and required to be insured hereunder, or which may be leased, rented, borrowed or in ​ the care custody or control of Tenant, or Tenant’s agents, employees or subcontractors. Such ​ insurance, with respect only to all Tenant Improvements, Alterations or other work performed on ​ the Premises by Tenant (collectively, “Tenant Work”), shall name Landlord and Landlord’s ​ current and future mortgagees as loss payees as their interests may appear. Such insurance shall ​ be written on an “all risk” of physical loss or damage basis including the perils of fire, extended ​ coverage, electrical injury, mechanicalbreakdown, windstorm, vandalism, malicious mischief, ​ sprinkler leakage, back-up of sewers or drains, flood, earthquake, terrorism and such other risks ​ Landlord may from time to time designate, for the full replacement cost value of the covered ​ items with an agreed amount endorsement with no co-insurance. Business interruption coverage ​ shall have limits sufficient to cover Tenant’s lost profits and necessary continuing expenses, ​ including rents due Landlord under the Lease. The minimum period of indemnity for business ​ interruption coverage shall be twelve (12) months plus twelve (12) months’ extended period of ​ indemnity. ​ ​ 42 ​ ​ ​ (d) Workers’ Compensation insurance as is required by statute or law, or as ​ may be available on a voluntary basis and Employers’ Liability insurance with limits of not less ​ than the following: each accident, Five Hundred Thousand Dollars ($500,000); disease (each ​ employee), Five Hundred Thousand Dollars ($500,000). ​ ​ (e) Medical malpractice insurance at limits of not less than $1,000,000 each ​ claim during such periods, if any, that Tenant engages in the practice of medicine at the ​ Premises. ​ ​ (f) Pollution Legal Liability insurance is required if Tenant stores, handles, ​ generates or treats Hazardous Materials, as determined solely by Landlord, on or about the ​ Premises. Such coverage shall include bodily injury, sickness, disease, death or mental anguish ​ or shock sustained by any person; property damage including physical injury to or destruction of ​ tangible property including the resulting loss of use thereof, clean-up costs, and the loss of use of ​ tangible property that has not been physically injured or destroyed; and defense costs, charges ​ and expenses incurred in the investigation, adjustment or defense of claims for such ​ compensatory damages. Coverage shall apply to both sudden and non-sudden pollution ​ conditions including the discharge, dispersal, release or escape of smoke, vapors, soot, fumes, ​ acids, alkalis, toxic chemicals, liquids or gases, waste materials or other irritants, contaminants ​ or pollutantsinto or upon land, the atmosphere or any watercourse or body of water. Claims- ​ made coverage is permitted, provided the policy retroactive date is continuously maintained ​ prior to the commencement date of this agreement, and coverage is continuously maintained ​ during all periods in which Tenant occupies the Premises. Coverage shall be maintained with ​ limits of not less than $1,000,000 per incident with a $2,000,000 policy aggregate and for a ​ period of two (2) years thereafter. ​ ​ (g) During all construction by Tenant at the Premises, with respect to tenant ​ improvements being constructed (including the Tenant Improvements and any Alterations), ​ insurance required in Exhibit B-1 must be in place. ​ ​ 23.4. The insurance required of Tenant by this Article shall be with companies at all ​ times having a current rating of not less than A- and financial category rating of at least Class ​ VII in “A.M. Best’s Insurance Guide” current edition. Tenant shall obtain for Landlord from the ​ insurance companies/broker or cause the insurance companies/broker to furnish certificates of ​ insurance evidencing all coverages required herein to Landlord. Landlord reserves the right to ​ require complete, certified copies of all required insurance policies including any endorsements. ​ No such policy shall be cancelable or subject to reduction of coverage or other modification or ​ cancellation except after twenty (20) days’ prior written notice to Landlord from Tenant or its ​ insurers (except in theevent of non-payment of premium, in which case ten (10) days’ written ​ notice shall be given). Tenant may modify, reduce or change insurance companies/brokers ​ without prior written notice to Landlord so long as such changes do not cause Tenant to have a ​ lapse in coverage or fail to satisfy Tenant’s obligations under this Section 23. All such policies ​ shall be written as primary policies, not contributing with and not in excess of the coverage that ​ Landlord may carry. Tenant’s required policies shall contain severability of interests clauses ​ stating that, except with respect to limits of insurance, coverage shall apply separately to each ​ insured or additional insured. Tenant shall, at least five (5) days prior to the expiration of such ​ ​ 43 ​ ​ ​ policies, furnish Landlord with renewal certificates of insurance or binders. Tenant agrees that if ​ Tenant does not take out and maintain such insurance, Landlord may (but shall not be required ​ to) procure such insurance on Tenant’s behalf and at its cost to be paid by Tenant as Additional ​ Rent. Commercial General Liability, Commercial Automobile Liability, Umbrella Liability and ​ Pollution Legal Liability insurance as required above shall name Landlord, BioMed Realty, L.P., ​ and BRE Edison Parent L.P., and their respective officers, employees, agents, general partners, ​ members, subsidiaries, affiliates and Lenders (“Landlord Parties”) as additional insureds as ​ respects liability arising from work or operations performed by or on behalf of Tenant, Tenant’s ​ use or occupancy of Premises, and ownership, maintenance or use of vehicles by or on behalf of ​ Tenant. ​ ​ 23.5. In each instance where insurance is to name Landlord Parties as additional ​ insureds, Tenant shall, upon Landlord’s written request, also designate and furnish certificates ​ evidencing such Landlord Parties as additional insureds to (a) any Lender of Landlord holding a ​ security interest in the Building or the Project, (b) the landlord under any lease whereunder ​ Landlord is a tenant of the real property upon which the Building is located if the interest of ​ Landlord is or shall become that of a tenant under a ground lease rather than that of a fee owner ​ and (c) any management company retainedby Landlord to manage the Project. ​ ​ 23.6. Tenant assumes the risk of damage to any fixtures, goods, inventory, ​ merchandise, equipment and leasehold improvements, and Landlord shall not be liable for injury ​ to Tenant’s business or any loss of income therefrom, relative to such damage, all as more ​ particularly set forth within this Lease. Tenant shall, at Tenant’s sole cost and expense, carry ​ such insurance as Tenant desires for Tenant’s protection with respect to personal property of ​ Tenant or business interruption. ​ ​ 23.7. Landlord, Tenant and each of their respective insurers hereby waive any and all ​ rights of recovery or subrogation against one another or against the officers, employees, agents, ​ general partners, members, subsidiaries and affiliates of the other (or against any Lenders of ​ Landlord) as respects any loss, damage, claims, suits or demands, howsoever caused, that are ​ covered, or should have been covered, by valid and collectible insurance, including any ​ deductibles or self-insurance maintained thereunder. If necessary, each party agrees to endorse ​ the required insurance policies to permit waivers of subrogation as required hereunder and hold ​ harmless and indemnify the other party for any loss or expense incurred as a result of a failure to ​ obtain such waivers of subrogation from insurers. Such waivers shall continue so long as their ​ respective insurers so permit. Any termination of such a waiver shallbe by written notice to the ​ other party, containing a description of the circumstances hereinafter set forth in this ​ Section 23.7. Landlord and Tenant, upon obtaining the policies of insurance required or ​ permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing ​ mutual waiver of subrogation is contained in this Lease. If such policies shall not be obtainable ​ with such waiver or shall be so obtainable only at a premium over that chargeable without such ​ waiver, then the party seeking such policy shall notify the other of such conditions, and the party ​ so notified shall have ten (10) days thereafter to either (a) procure such insurance with ​ companies reasonably satisfactory to the other party or (b) agree to pay such additional premium ​ (in Tenant's case, in the proportion that the area of the Premises bears to the insured area). If the ​ parties do not accomplish either (a) or (b), then this Section 23.7 shall have no effect during such ​ ​ 44 ​ ​ 45 ​ time as such policies shall not be obtainable or the party in whose favor a waiver of subrogation ​ is desired refuses to pay the additional premium. If such policies shall at any time be ​ unobtainable, but shall be subsequently obtainable, then neither party shall be subsequently ​ liable for a failure to obtain such insurance until a reasonable time after notification thereof by ​ the other party. If the release of either Landlord or Tenant, as set forth in the first sentence of ​ this Section 23.7, shall contravene Applicable Laws, then the liability of the party in question ​ shall be deemed not released but shall be secondary to the other party's insurer. ​ ​ 23.8. Landlord may require insurance policy limits required under this Lease to be ​ raised to conform with requirements of Landlord’s Lender or to bring coverage limits to levels ​ then being required of new tenants within the Project. ​ ​ 23.9. Any costs incurred by Landlord pursuant to this Article shall constitute a portion ​ of Operating Expenses to the extent that such costs may properly be included in Operating ​ Expenses under Article 9. ​ ​ 23.10. ​ this Lease. ​ The provisions of this Article shall survive the expiration or earlier termination of ​ ​ 24. Damage or Destruction. ​ 24.1. In the event of a partial destruction of (a) the Premises, (b) the Building, (c) the ​ Common Area or (d) the Project ((a)-(d) collectively, the “Affected Areas”) by fire or other ​ perils covered by extended coverage insurance not exceeding twenty-five percent (25%) of the ​ full insurable value thereof, andprovided that (w) the damage thereto is such that the Affected ​ Areas may be repaired, reconstructed or restored within a period of six (6) months from the date ​ of the happening of such casualty, (x) Landlord shall receive insurance proceeds from its insurer ​ or Lender sufficient to cover the cost of such repairs, reconstruction and restoration (except for ​ any deductible amount provided by Landlord’s policy, which deductible amount, if paid by ​ Landlord, shall constitute an Operating Expense) (y) the repair, reconstruction or restoration of ​ the Affected Areas is permitted by all applicable Loan Documents or otherwise consented to by ​ any and all Lenders whose consent is required thereunder, and (z) such casualty was not ​ intentionally caused by a Tenant Party, then Landlord shall commence and proceed diligently ​ with the work of repair, reconstruction and restoration of the Affected Areas and this Lease shall ​ continue in full force and effect. ​ ​ 24.2. In the event of any damage to or destruction of the Building or the Project other ​ than as described in Section 24.1, Landlord may elect to repair, reconstruct and restore the ​ Building or the Project, as applicable, in which case this Lease shall continue in full force and ​ effect. If Landlord elects not to repair, reconstruct and restore the Building or the Project, as ​ applicable, then this Lease shall terminate as of the date of such damage or destruction. In the ​ event of any damage or destruction (regardless of whether suchdamage is governed by ​ Section 24.1 or this Section), if (a) in Landlord's determination as set forth in the Damage Repair ​ Estimate (as defined below), the Affected Areas cannot be repaired, reconstructed or restored ​ within twelve (12) months after the date of the Damage Repair Estimate, (b) subject to ​ Section 24.6, the Affected Areas are not actually repaired, reconstructed and restored by the later ​ of (i) twelve (12) months after the date of the Damage Repair Estimate or (ii) ninety (90) days ​ ​ 46 ​ after the date set forth in the Damage Repair Estimate for such repairs, reconstruction or ​ restoration to be complete, or (c) the damage and destruction occurs within the last twelve (12) ​ months of the then-current Term, then Tenant shall have the right to terminate this Lease, ​ effective as of the date of such damage or destruction, by delivering to Landlord its written ​ notice of termination (a "Termination Notice") (y) with respect to Subsections 24.2(a) and (c), no ​ later than fifteen (15) days after Landlord delivers to Tenant Landlord's Damage Repair Estimate ​ and (z) with respect to Subsection 24.2(b), no later than fifteen (15) days after the later of the ​ dates set forth therein (as the same may be extended pursuant to Section 24.6) expires. ​ ​ 24.3. As soon as reasonably practicable, but in any event within sixty (60) days ​ following the date of damage or destruction, Landlord shall notify Tenant of Landlord's good ​ faith estimate of the period of time in which the repairs, reconstruction and restoration will be ​ completed (the "Damage Repair Estimate"), which estimate shall be based upon the opinion of a ​ contractor reasonably selected by Landlord and experienced in comparable repair, reconstruction ​ and restoration of similar buildings. Additionally, Landlord shall give written notice to Tenant ​ within ninety (90) days following the date of damage or destruction of its election not to repair, ​ reconstruct or restore the Building or the Project, as applicable. ​ ​ 24.4. Upon any termination of this Lease under any of theprovisions of this Article, the ​ parties shall be released thereby without further obligation to the other from the date possession ​ of the Premises is surrendered to Landlord, except with regard to (a) items occurring prior to the ​ damage or destruction and (b) provisions of this Lease that, by their express terms, survive the ​ expiration or earlier termination hereof. ​ ​ 24.5. In the event of repair, reconstruction and restoration as provided in this Article, ​ all Rent to be paid by Tenant under this Lease shall be abated proportionately based on the ​ extent to which Tenant’s use of the Premises is impaired commencing as of the date of damage ​ and continuing during the period of such repair, reconstruction or restoration, unless Landlord ​ provides Tenant with other space during the period of repair, reconstruction and restoration that, ​ in Tenant’s sole opinion, is suitable for the temporary conduct of Tenant’s business; provided, ​ however, that the amount of such abatement shall be reduced by the amount of Rent that is ​ received by Tenant as part of the business interruption or loss of rental income with respect to ​ the Premises from the proceeds of business interruption or loss of rental income insurance. ​ ​ 24.6. Notwithstanding anything to the contrary contained in this Article (a) Landlord ​ shall not be required to repair, reconstruct or restore any damage or destruction to the extent that ​ Landlord is prohibited from doing so by any applicable Loan Document or any Lender whose ​ consent isrequired thereunder withholds its consent, and (b) should Landlord be delayed or ​ prevented from completing the repair, reconstruction or restoration of the damage or destruction ​ to the Premises after the occurrence of such damage or destruction by Force Majeure or delays ​ caused by a Lender or Tenant Party, then the time for Landlord to commence or complete ​ repairs, reconstruction and restoration shall be extended on a day-for-day basis; provided, ​ however, that, at Landlord’s election, if such delays total more than ninety (90) days in the ​ aggregate, Landlord shall be relieved of its obligation to make such repairs, reconstruction and ​ restoration. ​ ​ 47 ​ 24.7. If Landlord is obligated to or elects to repair, reconstruct or restore as herein ​ provided, then Landlord shall be obligated to make such repairs, reconstruction or restoration ​ only with regard to (a) those portions of the Premises that were originally provided at Landlord’s ​ expense and (b) the Common Area portion of the Affected Areas. The repairs, reconstruction or ​ restoration of improvements not originally provided by Landlord or at Landlord’s expense shall ​ be the obligation of Tenant. In the event Tenant has elected to upgrade certain improvements ​ from the Building Standard, Landlord shall, upon the need for replacement due to an insured ​ loss, provide only the Building Standard, unless Tenant again elects to upgrade such ​ improvements and pay any incremental costs related thereto, except to the extent that excess ​ insurance proceeds, if received, are adequate to provide such upgrades, in addition to providing ​ for basic repairs, reconstruction and restoration of the Premises, the Building and the Project. ​ ​ 24.8. Notwithstanding anything to the contrary contained in this Article, Landlord shall ​ not have any obligation whatsoever to repair, reconstruct or restore the Premises if the damage ​ resulting from any casualty covered under this Article occurs during the last twenty-four (24) ​ months of the Term or any extension thereof, or to the extent that insurance proceeds are not ​ available therefor; provided that in the event Tenant has an unexercisedoption to extend the ​ Term of this Lease, Tenant may elect to exercise such option early, in which case the remaining ​ Term will be calculated based on the Term as extended for purposes of this Section. ​ ​ 24.9. Landlord’s obligation, should it elect or be obligated to repair, reconstruct or ​ restore, shall be limited to the Affected Areas, and shall be conditioned upon Landlord receiving ​ any permits or authorizations required by Applicable Laws, and in such event Landlord will use ​ commercially reasonable efforts to obtain such permits or authorizations. Tenant shall, at its ​ expense, replace or fully repair all of Tenant’s personal property and any Alterations installed by ​ Tenant existing at the time of such damage or destruction. If Affected Areas are to be repaired, ​ reconstructed or restored in accordance with the foregoing, Landlord shall make available to ​ Tenant any portion of insurance proceeds it receives that are allocable to the Alterations ​ constructed by Tenant pursuant to this Lease; provided Tenant is not then in Default under this ​ Lease, and subject to the requirements of any Lender of Landlord. ​ ​ 24.10. This Article sets forth the terms and conditions upon which this Lease may ​ terminate in the event of any damage or destruction. Accordingly, the parties hereby waive the ​ provisions of California Civil Code Sections 1932(2) and 1933(4) (and any successor statutes) ​ permitting the parties to terminate this Lease as a result of any damage or destruction. ​ 25. Eminent Domain. ​ 25.1. In the event (a) the whole of all Affected Areas or (b) such part thereof as shall ​ substantially interfere with Tenant’s use and occupancy of the Premises for the Permitted Use ​ shall be taken for any public or quasi-public purpose by any lawful power or authority by ​ exercise of the right of appropriation, condemnation or eminent domain, or sold to prevent such ​ taking, Tenant or Landlord may terminate this Lease effective as of the date possession is ​ required to be surrendered to such authority, except with regard to (y) items occurring prior to ​ the taking and (z) provisions of this Lease that, by their express terms, survive the expiration or ​ earlier termination hereof. ​ ​ 48 ​ 25.2. In the event of a partial taking of (a) the Building or the Project or (b) drives, ​ walkways or parking areas serving the Building or the Project for any public or quasi-public ​ purpose by any lawful power or authority by exercise of right of appropriation, condemnation, or ​ eminent domain, or sold to prevent such taking, then, without regard to whether any portion of ​ the Premises occupied by Tenant was so taken, Landlord may elect to terminate this Lease ​ (except with regard to (y) items occurring prior to the taking and (z) provisions of this Lease ​ that, by their express terms, survive the expiration or earlier termination hereof) as of such taking ​ if such taking is, in Landlord’s sole opinion, of a material nature such as to make it ​ uneconomical to continue use of the unappropriated portion for purposes of renting office or ​ laboratory space. ​ ​ 25.3. To the extent permitted under all applicable Loan Documents or otherwise ​ consented to by any and all Lenders whose consent is required thereunder, Tenant shall be ​ entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s ​ personal property that was installed at Tenant’s expense, (b) the costs of Tenant moving to a new ​ location and (c) loss of Tenant’s goodwill. Except as set forth in the previous sentence, any ​ award for such taking shall be the property of Landlord. ​ ​ 25.4. If, upon any taking of the nature described in this Article, this Lease continues in ​ effect, then Landlord shall promptlyproceed to restore the Affected Areas to substantially their ​ same condition prior to such partial taking. To the extent such restoration is infeasible, as ​ determined by Landlord in its sole and absolute discretion, the Rent shall be decreased ​ proportionately to reflect the loss of any portion of the Premises no longer available to Tenant. ​ Notwithstanding anything to the contrary contained in this Article, Landlord shall not be ​ required to restore the Affected Areas to the extent that Landlord is prohibited from doing so by ​ any applicable Loan Document or any Lender whose consent is required thereunder withholds its ​ consent. ​ ​ 25.5. This Article sets forth the terms and conditions upon which this Lease may ​ terminate in the event of any damage or destruction. Accordingly, the parties hereby waive the ​ provisions of California Code of Civil Procedure Section 1265.130 (and any successor statutes) ​ permitting the parties to terminate this Lease as a result of any damage or destruction. ​ ​ 26. Surrender. ​ 26.1. At least fifteen (15) days prior to Tenant’s surrender of possession of any part of ​ the Premises, Tenant shall provide Landlord with a facility decommissioning and Hazardous ​ Materials closure plan for the Premises (“Exit Survey”) prepared by an independent third party ​ state-certified professional with appropriate expertise, which Exit Survey must be reasonably ​ acceptable to Landlord. The Exit Survey shall comply with the American National Standards ​ Institute’sLaboratory Decommissioning guidelines (ANSI/AIHA Z9.11-2008) or any successor ​ standards published by ANSI or any successor organization (or, if ANSI and its successors no ​ longer exist, a similar entity publishing similar standards). In addition, at least ten (10) days ​ prior to Tenant’s surrender of possession of any part of the Premises, Tenant shall (a) provide ​ Landlord with (i) written evidence showing Tenant’s application for all appropriate ​ governmental releases and written evidence showing Tenant has passed the required inspections ​ necessary for such governmental releases in accordance with Applicable Laws, including laws ​ ​ 49 ​ pertaining to the surrender of the Premises, if any, and (ii) in the event that Tenant used or stored ​ radioactive materials in the Premises, all governmental releases required by Applicable Laws in ​ connection with such use or storage (e.g., proof of radioactive materials license closure), (b) ​ place Laboratory Equipment Decontamination Forms on all decommissioned equipment to ​ assure safe occupancy by future users and (c) conduct a site inspection with Landlord. In ​ addition, Tenant agrees to remain responsible after the surrender of the Premises for the ​ remediation of any recognized environmental conditions set forth in the Exit Survey and comply ​ with any recommendations set forth in the Exit Survey. Tenant’s obligations under this Section ​ shall survive the expiration or earlier termination of the Lease. ​ ​ 26.2. No surrender of possession of any part of the Premises shall release Tenant from ​ any of its obligations hereunder, unless such surrender is accepted in writing by Landlord. ​ ​ 26.3. The voluntary or other surrender of this Lease by Tenant shall not effect a merger ​ with Landlord’s fee title or leasehold interest in the Premises, the Building, the Property or the ​ Project, unless Landlord consents in writing, and shall, at Landlord’s option, operate as an ​ assignment to Landlord of any or all subleases. ​ ​ 26.4. The voluntary or other surrender of any ground or other underlying lease that now ​ exists or may hereafter be executed affecting the Building or the Project, ora mutual cancellation ​ thereof or of Landlord’s interest therein by Landlord and its lessor shall not effect a merger with ​ Landlord’s fee title or leasehold interest in the Premises, the Building or the Property and shall, ​ at the option of the successor to Landlord’s interest in the Building or the Project, as applicable, ​ operate as an assignment of this Lease. ​ ​ 27. Holding Over. ​ 27.1. If, with Landlord’s prior written consent, Tenant holds possession of all or any ​ part of the Premises after the Term, Tenant shall become a tenant from month to month after the ​ expiration or earlier termination of the Term, and in such case Tenant shall continue to pay (a) ​ Base Rent in accordance with Article 7, as adjusted in accordance with Article 8, and (b) any ​ amounts for which Tenant would otherwise be liable under this Lease if the Lease were still in ​ effect, including payments for Tenant’s Adjusted Share of Operating Expenses. Any such ​ month-to-month tenancy shall be subject to every other term, covenant and agreement contained ​ herein. ​ ​ 27.2. Notwithstanding the foregoing, if Tenant remains in possession of the Premises ​ after the expiration or earlier termination of the Term without Landlord’s prior written consent, ​ (a) Tenant shall become a tenant at sufferance subject to the terms and conditions of this Lease, ​ except that the monthly rent shall be equal to (i) one hundred twenty-five percent (125%) of the ​ Rent in effect during the last thirty (30) days of the Term for the first three (3) months of such ​ holdover, and (ii)one hundred fifty percent (150%) thereafter, and (b) Tenant shall be liable to ​ Landlord for any and all damages suffered by Landlord as a result of such holdover, including ​ any lost rent or consequential, special and indirect damages (in each case, regardless of whether ​ such damages are foreseeable). ​ ​ 50 ​ 27.3. Acceptance by Landlord of Rent after the expiration or earlier termination of the ​ Term shall not result in an extension, renewal or reinstatement of this Lease. ​ ​ 27.4. The foregoing provisions of this Article are in addition to and do not affect ​ Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by ​ Applicable Laws. ​ ​ 27.5. ​ this Lease. ​ The provisions of this Article shall survive the expiration or earlier termination of ​ ​ 28. Indemnification and Exculpation. ​ 28.1. Except to the extent caused by Landlord’s negligence or willful misconduct, ​ Tenant agrees to Indemnify the Landlord Indemnitees from and against any and all Claims of ​ any kind or nature, real or alleged, arising from (a) injury to or death of any person or damage to ​ any property occurring within or about the Premises, the Building, the Property or the Project, ​ arising directly or indirectly out of (i) the presence at or use or occupancy of the Premises or ​ Project by a Tenant Party, (ii) an act or omission on the part of any Tenant Party, (b) a breach or ​ default by Tenant in the performance of any of its obligations hereunder (including any Claim ​ asserted by any Lender against any Landlord Indemnitees under any Loan Document as a direct ​ result of such breach or default by Tenant) or (c) injury to or death of persons or damage to or ​ loss of any property, real or alleged, arising from the serving of alcoholic beverages at the ​ Premises or Project, including liability under any dram shop law, host liquor lawor similar ​ Applicable Law. Tenant’s obligations under this Section shall not be affected, reduced or ​ limited by any limitation on the amount or type of damages, compensation or benefits payable by ​ or for Tenant under workers’ compensation acts, disability benefit acts, employee benefit acts or ​ similar legislation. Subject to Sections 23.6, 23.7, 28.2 and 31.12 and any subrogation provisions ​ contained in the Work Letter, Landlord agrees to Indemnify the Tenant Parties from and against ​ any and all Claims arising from injury to or death of any person or damage to or loss of any ​ physical property occurring within or about the Premises, the Building, the Property or the ​ Project to the extent directly arising out of Landlord’s gross negligence or willful misconduct. ​ Landlord’s and Tenant’s obligations under this Section shall survive the expiration or earlier ​ termination of this Lease. ​ ​ 28.2. Notwithstanding anything in this Lease to the contrary, Landlord shall not be ​ liable to Tenant for and Tenant assumes all risk of (a) damage or losses caused by fire, electrical ​ malfunction, gas explosion or water damage of any type (including broken water lines, ​ malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), unless any such loss is ​ due to Landlord’s willful disregard of written notice by Tenant of need for a repair that Landlord ​ is responsible to make for an unreasonable period of time, and (b) damage to personal property ​ or scientific research, including loss of recordskept by Tenant within the Premises (in each case, ​ regardless of whether such damages are foreseeable). Tenant further waives any claim for injury ​ to Tenant’s business or loss of income relating to any such damage or destruction of personal ​ property as described in this Section. Notwithstanding anything in the foregoing or this Lease to ​ the contrary, except (x) as otherwise provided herein (including Section 27.2) or (y) in the event ​ of Tenant’s breach of Article 21 or Section 26.1, in no event shall Landlord or Tenant be liable ​ to the other for any consequential, special or indirect damages arising out of this Lease, ​ ​ ​ including lost profits (provided that this Subsection 28.2(z) shall not limit Tenant’s liability for ​ Base Rent or Additional Rent pursuant to this Lease). ​ ​ 28.3. Landlord shall not be liable for any damages arising from any act, omission or ​ neglect of any other tenant in the Building or the Project, or of any other third party. ​ ​ 28.4. Tenant acknowledges that security devices and services, if any, while intended to ​ deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not ​ be liable for injuries or losses caused by criminal acts of third parties, and Tenant assumes the ​ risk that any security device or service may malfunction or otherwise be circumvented by a ​ criminal. If Tenant desires protection against such criminal acts, then Tenant shall, at Tenant’s ​ sole cost and expense, obtain appropriate insurance coverage. Tenant’s security programs and ​ equipment for the Premises shall be coordinated with Landlord and subject to Landlord’s ​ reasonable approval. ​ ​ 28.5. ​ this Lease. ​ The provisions of this Article shall survive the expiration or earlier termination of ​ ​ 29. Assignment or Subletting. ​ 29.1. Except as hereinafter expressly permitted, none of the following (each, a ​ “Transfer”), either voluntarily or by operation of Applicable Laws, shall be directly or indirectly ​ performed without Landlord’s prior written consent: (a) Tenant selling, hypothecating, ​ assigning, pledging, encumbering or otherwise transferring this Lease or subletting the Premises ​ or (b) a controllinginterest in Tenant being sold, assigned or otherwise transferred (other than as ​ a result of shares in Tenant being sold on a public stock exchange). For purposes of the ​ preceding sentence, “control” means (a) owning (directly or indirectly) more than fifty percent ​ (50%) of the stock or other equity interests of another person or (b) possessing, directly or ​ indirectly, the power to direct or cause the direction of the management and policies of such ​ person. Notwithstanding the foregoing, Tenant shall have the right to Transfer, without ​ Landlord’s prior written consent, Tenant’s interest in this Lease or the Premises or any part ​ thereof to any person or entity (i) that as of the date of determination and at all times thereafter ​ directly, or indirectly through one or more intermediaries, controls, is controlled by or is under ​ common control with Tenant, (ii) into which Tenant is merged or consolidated or (iii) that ​ acquires all or substantially all of the assets, stock, or other equity interest of Tenant ​ (collectively, a “Tenant’s Affiliate”); provided that Tenant shall notify Landlord in writing at ​ least fifteen (15) business days prior to the effectiveness of such Transfer to Tenant’s Affiliate ​ (an “Exempt Transfer”) and otherwise comply with the requirements of this Lease regarding ​ such Transfer; and provided, further, that the person that will be the tenant under this Lease after ​ the Exempt Transfer has a net worth (as of both the day immediately prior to and the day ​ immediately after the Exempt Transfer) that is equal to or greater than the net worth (as ofboth ​ the Execution Date and the date of the Exempt Transfer) of the transferring Tenant. For ​ purposes of the immediately preceding sentence, “control” requires both (a) owning (directly or ​ indirectly) more than fifty percent (50%) of the stock or other equity interests of another person ​ and (b) possessing, directly or indirectly, the power to direct or cause the direction of the ​ management and policies of such person. In no event shall Tenant perform a Transfer to or with ​ an entity that is a tenant at the Project or that is in discussions or negotiations with Landlord to ​ ​ 51 ​ ​ ​ lease premises at the Project. Notwithstanding anything in this Lease to the contrary, if (a) ​ Tenant or any proposed transferee, assignee or sublessee of Tenant has been required by any ​ prior landlord, Lender or Governmental Authority to take material remedial action in connection ​ with Hazardous Materials contaminating a property if the contamination resulted from such ​ party’s action or omission or use of the property in question or (b) Tenant or any proposed ​ transferee, assignee or sublessee is subject to a material enforcement order issued by any ​ Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, ​ then Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute ​ discretion (with respect to any such matter involving Tenant), and it shall not be unreasonable ​ for Landlord to withhold its consent to any proposed transfer, assignment or subletting (with ​ respect to any such matter involving a proposed transferee, assignee or sublessee). ​ ​ 29.2. In the event Tenant desires to effect a Transfer, then, at least thirty (30) but not ​ more than one hundred eighty (180) days prior to the date when Tenant desires the Transfer to ​ be effective (the “Transfer Date”), Tenant shall provide written notice to Landlord (the “Transfer ​ Notice”) containing information (including references) concerning the character of the proposed ​ transferee, assignee or sublessee; the anticipated Transfer Date; the most recentunconsolidated ​ financial statements of Tenant and of the proposed transferee, assignee or sublessee satisfying ​ the requirements of Section 40.2 (“Required Financials”); any ownership or commercial ​ relationship between Tenant and the proposed transferee, assignee or sublessee; copies of ​ Hazardous Materials Documents for the proposed transferee, assignee or sublessee; and the ​ consideration and all other material terms and conditions of the proposed Transfer, all in such ​ detail as Landlord shall reasonably require. ​ ​ 29.3. Landlord, in determining whether consent should be given to a proposed Transfer, ​ may give consideration to (a) the financial strength of Tenant and of such transferee, assignee or ​ sublessee (notwithstanding Tenant remaining liable for Tenant’s performance), (b) any change in ​ use that such transferee, assignee or sublessee proposes to make in the use of the Premises and ​ (c) Landlord’s desire to exercise its rights under Section 29.7 to cancel this Lease. In no event ​ shall Landlord be deemed to be unreasonable for declining to consent to a Transfer if any ​ applicable Loan Document prohibits such assignment or any Lender whose consent is required ​ thereunder withholds its consent, or if the Transfer is to a transferee, assignee or sublessee of ​ poor reputation, lacking financial qualifications or seeking a change in the Permitted Use, or ​ jeopardizing directly or indirectly the status ofLandlord or any of Landlord’s affiliates as a Real ​ Estate Investment Trust under the Internal Revenue Code of 1986 (as the same may be amended ​ from time to time, the “Revenue Code”). Notwithstanding anything contained in this Lease to ​ the contrary, (w) no Transfer shall be consummated on any basis such that the rental or other ​ amounts to be paid by the occupant, assignee, manager or other transferee thereunder would be ​ based, in whole or in part, on the income or profits derived by the business activities of such ​ occupant, assignee, manager or other transferee; (x) Tenant shall not furnish or render any ​ services to an occupant, assignee, manager or other transferee with respect to whom transfer ​ consideration is required to be paid, or manage or operate the Premises or any capital additions ​ so transferred, with respect to which transfer consideration is being paid; (y) Tenant shall not ​ consummate a Transfer with any person in which Landlord owns an interest, directly or ​ indirectly (by applying constructive ownership rules set forth in Section 856(d)(5) of the ​ Revenue Code); and (z) Tenant shall not consummate a Transfer with any person or in any ​ ​ 52 ​ ​ ​ manner that could cause any portion of the amounts received by Landlord pursuant to this Lease ​ or any sublease, license or other arrangement for the right to use, occupy or possess any portion ​ of the Premises to fail to qualify as “rents from real property” within the meaning of Section ​ 856(d) of the Revenue Code, or any similar or successor provision thereto or which could cause ​ any other income of Landlord to fail to qualify as income described in Section 856(c)(2) of the ​ Revenue Code. ​ ​ 29.4. The following are conditions precedent to a Transfer or to Landlord considering a ​ request by Tenant to a Transfer: ​ ​ (a) Tenant shall remain fully liable under this Lease. Tenant agrees that it ​ shall not be (and shall not be deemed to be) a guarantor or surety of this Lease, however, and ​ waives its right to claim that is it is a guarantor or surety or to raise in any legal proceeding any ​ guarantor or surety defenses permitted by this Lease or by Applicable Laws; ​ ​ (b) If Tenant or the proposed transferee, assignee or sublessee does not or ​ cannot deliver the Required Financials, then Landlord may elect to have either Tenant’s ultimate ​ parent company or the proposed transferee’s, assignee’s or sublessee’s ultimate parent company ​ provide a guaranty of the applicable entity’s obligations under this Lease, in a form acceptable to ​ Landlord, which guaranty shall be executed and delivered to Landlord by the applicable ​ guarantor prior to the Transfer Date; ​ ​ (c) In thecase of an Exempt Transfer, Tenant shall provide Landlord with ​ evidence reasonably satisfactory to Landlord that the Transfer qualifies as an Exempt Transfer; ​ ​ (d) Tenant shall provide Landlord with evidence reasonably satisfactory to ​ Landlord that the value of Landlord’s interest under this Lease shall not be diminished or ​ reduced by the proposed Transfer. Such evidence shall include evidence respecting the relevant ​ business experience and financial responsibility and status of the proposed transferee, assignee ​ or sublessee; ​ ​ (e) Tenant shall reimburse Landlord for Landlord’s actual costs and expenses, ​ including reasonable attorneys’ fees, charges and disbursements incurred in connection with the ​ review, processing and documentation of such request (collectively, “Transfer Fees”); provided, ​ however, that Tenant shall not be obligated to reimburse Landlord for any Transfer Fees in ​ excess of $2,500.00; ​ ​ (f) Except with respect to an Exempt Transfer, if Tenant’s transfer of rights or ​ sharing of the Premises provides for the receipt by, on behalf of or on account of Tenant of any ​ consideration of any kind whatsoever (including a premium rental for a sublease or lump sum ​ payment for an assignment, after deducting Tenant’s reasonable costs in marketing and ​ subleasing the Premises) in excess of the rental and other charges due to Landlord under this ​ Lease, Tenant shall pay fifty percent (50%) of all of suchexcess to Landlord, after making ​ deductions for any reasonable marketing expenses, tenant improvement funds expended by ​ Tenant, alterations, cash concessions, brokerage commissions, attorneys’ fees and free rent ​ actually paid by Tenant. If such consideration consists of cash paid to Tenant, payment to ​ Landlord shall be made upon receipt by Tenant of such cash payment; ​ 53 ​ ​ ​ (g) The proposed transferee, assignee or sublessee shall agree that, in the ​ event Landlord gives such proposed transferee, assignee or sublessee notice that Tenant is in ​ Default under this Lease, such proposed transferee, assignee or sublessee shall thereafter make ​ all payments otherwise due Tenant directly to Landlord, which payments shall be received by ​ Landlord without any liability being incurred by Landlord, except to credit such payment against ​ those due by Tenant under this Lease, and any such proposed transferee, assignee or sublessee ​ shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for ​ any reason; provided, however, that in no event shall Landlord or its Lenders, successors or ​ assigns be obligated to accept such attornment; ​ ​ ​ forms; ​ (h) Landlord’s consent to any such Transfer shall be effected on Landlord’s ​ ​ (i) Tenant shall not then be in Default hereunder; ​ ​ (j) Such proposed transferee, assignee or sublessee’s use of the Premises ​ shall be the same as the Permitted Use; ​ ​ (k) Landlord shall not be bound by any provision of any agreement pertaining ​ to the Transfer, except for Landlord’s written consent to the same; ​ ​ (l) Tenant shall pay all transfer and other taxes (including interest and ​ penalties) assessed or payable for any Transfer; ​ ​ (m) Landlord’s consent (or waiver of its rights) for any Transfer, if applicable, ​ shall not waive Landlord’s right toconsent or refuse consent to any later Transfer; ​ ​ (n) Tenant shall deliver to Landlord one executed copy of any and all written ​ instruments evidencing or relating to the Transfer; and ​ ​ (o) Tenant shall deliver to Landlord a list of Hazardous Materials (as defined ​ below), certified by the proposed transferee, assignee or sublessee to be true and correct, that the ​ proposed transferee, assignee or sublessee intends to use or store in the Premises. Additionally, ​ Tenant shall deliver to Landlord, on or before the date any proposed transferee, assignee or ​ sublessee takes occupancy of the Premises, all of the items relating to Hazardous Materials of ​ such proposed transferee, assignee or sublessee as described in Section 21.2. ​ ​ 29.5. Any Transfer that is not in compliance with the provisions of this Article or with ​ respect to which Tenant does not fulfill its obligations pursuant to this Article shall be void and ​ shall, at the option of Landlord, terminate this Lease. ​ ​ 29.6. Notwithstanding any Transfer, Tenant shall remain fully and primarily liable for ​ the payment of all Rent and other sums due or to become due hereunder, and for the full ​ performance of all other terms, conditions and covenants to be kept and performed by Tenant. ​ The acceptance of Rent or any other sum due hereunder, or the acceptance of performance of any ​ other term, covenant or condition thereof, from any person or entity other than Tenant shall not ​ be deemed a waiver of any of the provisions of thisLease or a consent to any Transfer. ​ ​ 54 ​ ​ ​ 29.7. If Tenant delivers to Landlord a Transfer Notice indicating a desire to (i) assign ​ this Lease (other than pursuant to an Exempt Transfer) or (ii) enter into a sublease which results ​ in more than fifty percent (50%) of the Premises being subject to a sublease for ninety-five ​ percent (95%) or more of the remaining Term (other than pursuant to an Exempt Transfer), then ​ Landlord shall have the option, exercisable by giving notice to Tenant at any time within thirty ​ (30) days after Landlord’s receipt of such Transfer Notice, to terminate this Lease as of the date ​ specified in the Transfer Notice as the Transfer Date, except for those provisions that, by their ​ express terms, survive the expiration or earlier termination hereof. If Landlord exercises such ​ option, then Tenant shall have the right to withdraw such Transfer Notice by delivering to ​ Landlord written notice of such election within five (5) days after Landlord’s delivery of notice ​ electing to exercise Landlord’s option to terminate this Lease. In the event Tenant withdraws the ​ Transfer Notice as provided in this Section, this Lease shall continue in full force and effect. No ​ failure of Landlord to exercise its option to terminate this Lease shall be deemed to be ​ Landlord’s consent to a proposed Transfer. ​ ​ 29.8. If Tenant sublets the Premises or any portion thereof, Tenant hereby immediately ​ and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all ​ rent from any such subletting, and appoints Landlord asassignee and attorney-in-fact for Tenant, ​ and Landlord (or a receiver for Tenant appointed on Landlord’s application) may collect such ​ rent and apply it toward Tenant’s obligations under this Lease; provided that, until the ​ occurrence of a Default (as defined below) by Tenant, Tenant shall have the right to collect such ​ rent. ​ ​ 29.9. In the event that Tenant enters into a sublease for the entire Premises in ​ accordance with this Article that expires within two (2) days of the Term Expiration Date, the ​ term expiration date of such sublease shall, notwithstanding anything in this Lease, the sublease ​ or any consent to the sublease to the contrary, be deemed to be the date that is two (2) days prior ​ to the Term Expiration Date. ​ ​ 30. Subordination and Attornment. ​ 30.1. This Lease shall be subject and subordinate to the lien of any mortgage, deed of ​ trust, or lease in which Landlord is tenant now or hereafter in force against the Building or the ​ Project and to all advances made or hereafter to be made upon the security thereof without the ​ necessity of the execution and delivery of any further instruments on the part of Tenant to ​ effectuate such subordination; provided, however, that a condition to such subordination will be ​ Tenant’s receipt of a Subordination, Non-Disturbance and Attornment Agreement in the form ​ attached hereto as Exhibit M or on another commercially reasonable form acceptable to ​ Landlord’s lender or lien holder. ​ ​ 30.2. Notwithstanding the foregoing, Tenantshall execute and deliver upon demand ​ such further instrument or instruments evidencing such subordination of this Lease to the lien of ​ any such mortgage or mortgages or deeds of trust or lease in which Landlord is tenant as may be ​ required by Landlord. If any Lender so elects, however, this Lease shall be deemed prior in lien ​ to any such lease, mortgage, or deed of trust upon or including the Premises regardless of date ​ and Tenant shall execute a statement in writing to such effect at Landlord’s request. If Tenant ​ fails to execute any document required from Tenant under this Section within ten (10) business ​ ​ 55 ​ ​ 56 ​ days after written request therefor, Tenant hereby constitutes and appoints Landlord or its special ​ attorney-in-fact to execute and deliver any such document or documents in the name of Tenant. ​ Such power is coupled with an interest and is irrevocable. For the avoidance of doubt, “Lender” ​ shall also include historic tax credit investors and new market tax credit investors. ​ ​ 30.3. Upon written request of Landlord and opportunity for Tenant to review, Tenant ​ agrees to execute any Lease amendments not materially altering the terms of this Lease, if ​ required by a Lender incident to the financing of the real property of which the Premises ​ constitute a part. ​ ​ 30.4. In the event any proceedings are brought for foreclosure, or in the event of the ​ exercise of the power of sale under any mortgage or deed of trust made by Landlord covering the ​ Premises, Tenant shall at the election of the purchaser at such foreclosure or sale attorn to the ​ purchaser upon any such foreclosure or sale and recognize such purchaser as Landlord under this ​ Lease. ​ ​ 31. Defaults and Remedies. ​ 31.1. Late payment by Tenant to Landlord of Rent and other sums due shall cause ​ Landlord to incur costs not contemplated by this Lease, the exact amount of which shall be ​ extremely difficult and impracticable to ascertain. Such costs include processing and accounting ​ charges and late charges that may be imposed on Landlord by the terms of any mortgage or trust ​deed covering the Premises. Therefore, if any installment of Rent due from Tenant is not ​ received by Landlord within five (5) business days after the date such payment is due, Tenant ​ shall pay to Landlord (a) an additional sum of four percent (4%) of the overdue Rent as a late ​ charge plus (b) interest at an annual rate (the “Default Rate”) equal to the lesser of (a) twelve ​ percent (12%) and (b) the highest rate permitted by Applicable Laws. The parties agree that this ​ late charge represents a fair and reasonable estimate of the costs that Landlord shall incur by ​ reason of late payment by Tenant and shall be payable as Additional Rent to Landlord due with ​ the next installment of Rent or within five (5) business days after Landlord’s demand, whichever ​ is earlier. Landlord’s acceptance of any Additional Rent (including a late charge or any other ​ amount hereunder) shall not be deemed an extension of the date that Rent is due or prevent ​ Landlord from pursuing any other rights or remedies under this Lease, at law or in equity. ​ ​ 31.2. No payment by Tenant or receipt by Landlord of a lesser amount than the Rent ​ payment herein stipulated shall be deemed to be other than on account of the Rent, nor shall any ​ endorsement or statement on any check or any letter accompanying any check or payment as ​ Rent be deemed an accord and satisfaction, and Landlord may accept such check or payment ​ without prejudice to Landlord’s right to recover thebalance of such Rent or pursue any other ​ remedy provided in this Lease or in equity or at law. If a dispute shall arise as to any amount or ​ sum of money to be paid by Tenant to Landlord hereunder, Tenant shall have the right to make ​ payment “under protest,” such payment shall not be regarded as a voluntary payment, and there ​ shall survive the right on the part of Tenant to institute suit for recovery of the payment paid ​ under protest. ​ ​ 31.3. If Tenant fails to pay any sum of money required to be paid by it hereunder or ​ perform any other act on its part to be performed hereunder, in each case within the applicable ​ ​ 57 ​ cure period (if any) described in Section 31.4, then Landlord may (but shall not be obligated to), ​ without waiving or releasing Tenant from any obligations of Tenant, make such payment or ​ perform such act; provided that such failure by Tenant unreasonably interfered with the use of ​ the Building or the Project by any other tenant or with the efficient operation of the Building or ​ the Project, or resulted or could have resulted in a violation of Applicable Laws or the ​ cancellation of an insurance policy maintained by Landlord. Notwithstanding the foregoing, in ​ the event of an emergency, Landlord shall have the right to enter the Premises and act in ​ accordance with its rights as provided elsewhere in this Lease. In addition to the late charge ​ described in Section 31.1, Tenant shall pay to Landlord as Additional Rent all sums so paid or ​ incurred by Landlord, together with interest at the Default Rate, computed from the date such ​ sums were paid or incurred. ​ ​ 31.4. The occurrence of any one or more of the following events shall constitute a ​ “Default” hereunder by Tenant: ​ ​ (a) Tenant abandons the Premises or vacates without providing a ​ commercially reasonable level of security; ​ ​ (b) Tenant fails to make any payment of Rent, as and when due, or to satisfy ​ its obligations under Article 19, where such failure shall continue for a period of five (5) ​ business days after written notice thereof from Landlord to Tenant; ​ ​ (c) Tenant fails to observe or perform any obligation or covenantcontained ​ herein (other than described in Sections 31.4(a) and 31.4(b)) to be performed by Tenant, where ​ such failure continues for a period of thirty (30) days after written notice thereof from Landlord ​ to Tenant; provided that, if the nature of Tenant’s default is such that it reasonably requires more ​ than thirty (30) days to cure, Tenant shall not be deemed to be in Default if Tenant commences ​ such cure within such thirty (30) day period and thereafter diligently prosecutes the same to ​ completion; and provided, further, that such cure is completed no later than ninety (90) days ​ after Tenant’s receipt of written notice from Landlord (unless Tenant’s ability to cure is outside ​ of Tenant’s control (provided that financial inability shall not be considered outside of Tenant’s ​ control), in which case the foregoing ninety (90) day period will not apply so long as Tenant ​ diligently pursues such cure as soon as it is able); ​ ​ (d) Tenant makes an assignment for the benefit of creditors; ​ ​ (e) A receiver, trustee or custodian is appointed to or does take title, ​ possession or control of all or substantially all of Tenant’s assets; ​ ​ (f) Tenant files a voluntary petition under the United States Bankruptcy Code ​ or any successor statute (as the same may be amended from time to time, the “Bankruptcy ​ Code”) or an order for relief is entered against Tenant pursuant to a voluntary or involuntary ​ proceeding commenced under any chapter of the Bankruptcy Code; ​ ​ (g) Any involuntary petition is filed against Tenant underany chapter of the ​ Bankruptcy Code and is not dismissed within one hundred twenty (120) days; ​ ​ 58 ​ (h) Tenant fails to deliver an estoppel certificate in accordance with Article 20 ​ after the additional notice and cure period provided in Article 20; or ​ ​ (i) Tenant’s interest in this Lease is attached, executed upon or otherwise ​ judicially seized and such action is not released within one hundred twenty (120) days of the ​ action. ​ ​ Notices given under this Section shall specify the alleged default and shall demand that Tenant ​ perform the provisions of this Lease or pay the Rent that is in arrears, as the case may be, within ​ the applicable period of time, or quit the Premises. No such notice shall be deemed a forfeiture ​ or a termination of this Lease unless Landlord elects otherwise in such notice. ​ ​ 31.5. In the event of a Default by Tenant, and at any time thereafter, with or without ​ notice or demand and without limiting Landlord in the exercise of any right or remedy that ​ Landlord may have, Landlord has the right to do any or all of the following: ​ ​ (a) Halt any Tenant Improvements and Alterations and order Tenant’s ​ contractors, subcontractors, consultants, designers and material suppliers to stop work; ​ ​ (b) Terminate Tenant’s right to possession of the Premises by written notice ​ to Tenant or by any lawful means, in which case Tenant shall immediately surrender possession ​ of the Premises to Landlord. In such event, Landlord shall have the immediate right to re-enter ​ and remove all persons and property, and such property may be removed and stored in a public ​ warehouse orelsewhere at the cost and for the account of Tenant, all without service of notice or ​ resort to legal process and without being deemed guilty of trespass or becoming liable for any ​ loss or damage that may be occasioned thereby; and ​ ​ (c) Terminate this Lease, in which event Tenant shall immediately surrender ​ possession of the Premises to Landlord. In such event, Landlord shall have the immediate right ​ to re-enter and remove all persons and property, and such property may be removed and stored in ​ a public warehouse or elsewhere at the cost and for the account of Tenant, all without service of ​ notice or resort to legal process and without being deemed guilty of trespass or becoming liable ​ for any loss or damage that may be occasioned thereby. In the event that Landlord shall elect to ​ so terminate this Lease, then Landlord shall be entitled to recover from Tenant all damages ​ incurred by Landlord by reason of Tenant’s default, including: ​ ​ (i) The sum of: ​ ​ A. The worth at the time of award of any unpaid Rent that had ​ accrued at the time of such termination; plus ​ ​ B. The worth at the time of award of the amount by which the ​ unpaid Rent that would have accrued during the period commencing with termination of the ​ Lease and ending at the time of award exceeds that portion of the loss of Landlord’s rental ​ income from the Premises that Tenant proves could have been reasonably avoided; plus ​ ​ 59 ​ C. The worth at the time of award of the amount by which the ​ unpaid Rent for the balance of the Term after the time of award exceeds that portion of the loss ​ of Landlord’s rental income from the Premises that Tenant proves could have been reasonably ​ avoided; plus ​ ​ D. Any other amount necessary to compensate Landlord for ​ all the detriment caused by Tenant’s failure to perform its obligations under this Lease or that in ​ the ordinary course of things would be likely to result therefrom, including the cost of restoring ​ the Premises to the condition required under the terms of this Lease, including any rent payments ​ not otherwise chargeable to Tenant (e.g., during any “free” rent period or rent holiday); plus ​ ​ E. At Landlord’s election, such other amounts in addition to ​ or in lieu of the foregoing as may be permitted from time to time by Applicable Laws. ​ ​ As used in Sections 31.5(c)(i)(A) and (B), “worth at the time of award” shall be computed by ​ allowing interest at the Default Rate. As used in Section 31.5(c)(i)(C), the “worth at the time of ​ the award” shall be computed by taking the present value of such amount, using the discount rate ​ of the Federal Reserve Bank of San Francisco at the time of the award plus one percent (1%). ​ ​ 31.6. In addition to any other remedies available to Landlord at law or in equity and ​ under this Lease, Landlord shall have the remedy described in California Civil Code Section ​ and may continue this Lease in effect after Tenant’s Default or abandonment and recoverRent ​ as it becomes due, provided Tenant has the right to sublet or assign, subject only to ​ reasonable limitations. In addition, subject to California Civil Code Section 1951.4, Landlord ​ shall not be liable in any way whatsoever for its failure or refusal to relet the Premises. For ​ purposes of this Section, the following acts by Landlord will not constitute the termination of ​ Tenant’s right to possession of the Premises: ​ ​ (a) Acts of maintenance or preservation or efforts to relet the Premises, ​ including alterations, remodeling, redecorating, repairs, replacements or painting as Landlord ​ shall consider advisable for the purpose of reletting the Premises or any part thereof; or ​ ​ (b) The appointment of a receiver upon the initiative of Landlord to protect ​ Landlord’s interest under this Lease or in the Premises. ​ ​ Notwithstanding the foregoing, in the event of a Default by Tenant, Landlord may elect at any ​ time to terminate this Lease and to recover damages to which Landlord is entitled. ​ ​ 31.7. If Landlord does not elect to terminate this Lease as provided in Section 31.5, ​ then Landlord may, from time to time, recover all Rent as it becomes due under this Lease. At ​ any time thereafter, Landlord may elect to terminate this Lease and to recover damages to which ​ Landlord is entitled. ​ ​ 31.8. In the event Landlord elects to terminate this Lease and relet the Premises, ​ Landlord may execute any new lease in its own name. Tenant hereunder shall have no right or ​ authority whatsoever to collect any Rent from suchtenant. The proceeds of any such reletting ​ shall be applied as follows: ​ ​ 60 ​ (a) First, to the payment of any indebtedness other than Rent due hereunder ​ from Tenant to Landlord, including storage charges or brokerage commissions owing from ​ Tenant to Landlord as the result of such reletting; ​ ​ (b) Second, to the payment of the costs and expenses of reletting the ​ Premises, including (i) alterations and repairs that Landlord deems reasonably necessary and ​ advisable and (ii) reasonable attorneys’ fees, charges and disbursements incurred by Landlord in ​ connection with the retaking of the Premises and such reletting; ​ ​ ​ hereunder; and ​ (c) Third, to the payment of Rent and other charges due and unpaid ​ ​ (d) Fourth, to the payment of future Rent and other damages payable by ​ Tenant under this Lease. ​ ​ 31.9. All of Landlord’s rights, options and remedies hereunder shall be construed and ​ held to be nonexclusive and cumulative. Landlord shall have the right to pursue any one or all of ​ such remedies, or any other remedy or relief that may be provided by Applicable Laws, whether ​ or not stated in this Lease. No waiver of any default of Tenant hereunder shall be implied from ​ any acceptance by Landlord of any Rent or other payments due hereunder or any omission by ​ Landlord to take any action on account of such default if such default persists or is repeated, and ​ no express waiver shall affect defaults other than as specified in such waiver. Landlord shall be ​ required to mitigate its damages with respectto any default by Tenant to the extent required by ​ Applicable Laws. Any such obligation imposed by Applicable Laws upon Landlord to relet the ​ Premises after any termination of this Lease shall be subject to the reasonable requirements of ​ Landlord to (a) lease to high quality tenants on such terms as Landlord may from time to time ​ deem appropriate in its discretion and (b) develop the Project in a harmonious manner with a mix ​ of uses, tenants, floor areas, terms of tenancies, etc., as determined by Landlord. Landlord shall ​ not be obligated to relet the Premises to (y) any Tenant’s Affiliate or (z) any party (i) ​ unacceptable to a Lender, (ii) that requires Landlord to make improvements to or re-demise the ​ Premises, (iii) that desires to change the Permitted Use, (iv) that desires to lease the Premises for ​ more or less than the remaining Term or (v) to whom Landlord or an affiliate of Landlord may ​ desire to lease other available space in the Project or at another property owned by Landlord or ​ an affiliate of Landlord. ​ ​ 31.10. Landlord’s termination of (a) this Lease or (b) Tenant’s right to possession of the ​ Premises shall not relieve Tenant of any liability to Landlord that has previously accrued or that ​ shall arise based upon events that occurred prior to the later to occur of (y) the date of Lease ​ termination and (z) the date Tenant surrenders possession of the Premises. ​ ​ 31.11. To the extent permitted by Applicable Laws, Tenant waives any and all rights of ​ redemption granted by or under anypresent or future Applicable Laws if Tenant is evicted or ​ dispossessed for any cause, or if Landlord obtains possession of the Premises due to Tenant’s ​ default hereunder or otherwise. ​ ​ 31.12. Landlord shall not be in default or liable for damages under this Lease unless ​ Landlord fails to perform obligations required of Landlord within a reasonable time, but in no ​ ​ 61 ​ event shall such failure continue for more than thirty (30) days after written notice from Tenant ​ specifying the nature of Landlord’s failure; provided, however, that if the nature of Landlord’s ​ obligation is such that more than thirty (30) days are required for its performance, then Landlord ​ shall not be in default if Landlord commences performance within such thirty (30) day period ​ and thereafter diligently prosecutes the same to completion. In no event shall Tenant have the ​ right to terminate or cancel this Lease or to withhold or abate rent or to set off any Claims ​ against Rent as a result of any default or breach by Landlord of any of its covenants, obligations, ​ representations, warranties or promises hereunder, except as may otherwise be expressly set ​ forth in this Lease. ​ ​ 31.13. In the event of any default by Landlord, Tenant shall give notice by registered or ​ certified mail or by nationally recognized overnight courier (such as FedEx or UPS) to any (a) ​ beneficiary of a deed of trust or (b) mortgagee under a mortgage covering the Premises, the ​ Building or the Project and to any landlord of any lease of land upon or within which the ​ Premises, the Building or the Project is located, and shall offer such beneficiary, mortgagee or ​ landlord a reasonable opportunity to cure the default, including time to obtain possession of the ​ Building or the Project by power of sale or a judicial action if such should prove necessary to ​ effect a cure; provided that Landlord shall furnish to Tenant in writing, uponwritten request by ​ Tenant, the names and addresses of all such persons who are to receive such notices. ​ ​ 32. Bankruptcy . In the event a debtor, trustee or debtor in possession under the Bankruptcy ​ Code, or another person with similar rights, duties and powers under any other Applicable Laws, ​ proposes to cure any default under this Lease or to assume or assign this Lease and is obliged to ​ provide adequate assurance to Landlord that (a) a default shall be cured, (b) Landlord shall be ​ compensated for its damages arising from any breach of this Lease and (c) future performance of ​ Tenant’s obligations under this Lease shall occur, then such adequate assurances shall include ​ any or all of the following, as designated by Landlord in its sole and absolute discretion: ​ ​ 32.1. Those acts specified in the Bankruptcy Code or other Applicable Laws as ​ included within the meaning of “adequate assurance,” even if this Lease does not concern a ​ shopping center or other facility described in such Applicable Laws; ​ ​ 32.2. A prompt cash payment to compensate Landlord for any monetary defaults or ​ actual damages arising directly from a breach of this Lease; ​ ​ 32.3. A cash deposit in an amount at least equal to the then-current amount of the ​ Security Deposit; or ​ ​ 32.4. ​ this Lease. ​ The assumption or assignment of all of Tenant’s interest and obligations under ​ ​ 33. Brokers. ​ 33.1. Tenant represents and warrants that it has had nodealings with any real estate ​ broker or agent in connection with the negotiation of this Lease other than Hughes Marino ​ (“Broker”), and that it knows of no other real estate broker or agent that is or might be entitled to ​ ​ 62 ​ a commission in connection with this Lease. Landlord shall compensate Broker in relation to ​ this Lease pursuant to a separate agreement between Landlord and Broker. ​ ​ 33.2. Tenant represents and warrants that no broker or agent has made any ​ representation or warranty relied upon by Tenant in Tenant’s decision to enter into this Lease, ​ other than as contained in this Lease. ​ ​ 33.3. Tenant acknowledges and agrees that the employment of brokers by Landlord is ​ for the purpose of solicitation of offers of leases from prospective tenants and that no authority is ​ granted to any broker to furnish any representation (written or oral) or warranty from Landlord ​ unless expressly contained within this Lease. Landlord is executing this Lease in reliance upon ​ Tenant’s representations, warranties and agreements contained within Sections 33.1 and 33.2. ​ ​ 33.4. Tenant agrees to Indemnify the Landlord Indemnitees from any and all cost or ​ liability for compensation claimed by any broker or agent, other than Broker, employed or ​ engaged by Tenant or claiming to have been employed or engaged by Tenant. Landlord agrees ​ to indemnify Tenant from any and all cost or liability for compensation claimed by any broker or ​ agent, other than Broker or Jones Lang LaSalle (who represents Landlord in connection with this ​ Lease), employed or engaged by Landlord or claiming to have been employed or engaged by ​ Landlord. ​ ​ 34.Definition of Landlord. With regard to obligations imposed upon Landlord pursuant to ​ this Lease, the term “Landlord,” as used in this Lease, shall refer only to Landlord or Landlord’s ​ then-current successor-in-interest. In the event of any transfer, assignment or conveyance of ​ Landlord’s interest in this Lease or in Landlord’s fee title to or leasehold interest in the Property, ​ as applicable, Landlord herein named (and in case of any subsequent transfers or conveyances, ​ the subsequent Landlord) shall be automatically freed and relieved, from and after the date of ​ such transfer, assignment or conveyance, from all liability for the performance of any covenants ​ or obligations contained in this Lease thereafter to be performed by Landlord and, without ​ further agreement, the transferee, assignee or conveyee of Landlord’s in this Lease or in ​ Landlord’s fee title to or leasehold interest in the Property, as applicable, shall be deemed to ​ have assumed and agreed to observe and perform any and all covenants and obligations of ​ Landlord hereunder during the tenure of its interest in the Lease or the Property. Landlord or ​ any subsequent Landlord may transfer its interest in the Premises or this Lease without Tenant’s ​ consent. ​ ​ 35. Limitation of Landlord’s Liability. ​ 35.1. If Landlord is in default under this Lease and, as a consequence, Tenant recovers ​ a monetary judgment against Landlord, the judgment shall be satisfied only out of (a) the ​ proceeds of salereceived on execution of the judgment and levy against the right, title and ​ interest of Landlord in the Building and the Project, (b) rent or other income from such real ​ property receivable by Landlord or (c) the consideration received by Landlord from the sale, ​ financing, refinancing or other disposition of all or any part of Landlord’s right, title or interest ​ in the Building or the Project. ​ ​ 63 ​ 35.2. Neither Landlord nor any of its affiliates, nor any of their respective partners, ​ shareholders, directors, officers, employees, members or agents shall be personally liable for ​ Landlord’s obligations or any deficiency under this Lease, and service of process shall not be ​ made against any shareholder, director, officer, employee or agent of Landlord or any of ​ Landlord’s affiliates. No partner, shareholder, director, officer, employee, member or agent of ​ Landlord or any of its affiliates shall be sued or named as a party in any suit or action, and ​ service of process shall not be made against any partner or member of Landlord except as may ​ be necessary to secure jurisdiction of the partnership, joint venture or limited liability company, ​ as applicable. No partner, shareholder, director, officer, employee, member or agent of Landlord ​ or any of its affiliates shall be required to answer or otherwise plead to any service of process, ​ and no judgment shall be taken or writ of execution levied against any partner, shareholder, ​ director, officer, employee, member or agent of Landlord or any of its affiliates. ​ ​ 35.3. Each of the covenants and agreements of this Article shall be applicable to any ​ covenant or agreement either expressly contained in this Lease or imposed by Applicable Laws ​ and shall survive the expiration or earlier termination of this Lease. ​ ​ 36. Joint and Several Obligations. If more than one person or entity executes this Lease as ​ Tenant, then: ​ ​ 36.1. Each of them is jointlyand severally liable for the keeping, observing and ​ performing of all of the terms, covenants, conditions, provisions and agreements of this Lease to ​ be kept, observed or performed by Tenant, and such terms, covenants, conditions, provisions and ​ agreements shall be binding with the same force and effect upon each and all of the persons ​ executing this Agreement as Tenant; and ​ ​ 36.2. The term “Tenant,” as used in this Lease, shall mean and include each of them, ​ jointly and severally. The act of, notice from, notice to, refund to, or signature of any one or ​ more of them with respect to the tenancy under this Lease, including any renewal, extension, ​ expiration, termination or modification of this Lease, shall be binding upon each and all of the ​ persons executing this Lease as Tenant with the same force and effect as if each and all of them ​ had so acted, so given or received such notice or refund, or so signed. ​ ​ 37. Representations. Tenant represents and warrants that (a) Tenant is duly incorporated or ​ otherwise established or formed and validly existing under the laws of its state of incorporation, ​ establishment or formation, (b) Tenant has and is duly qualified to do business in the state in ​ which the Property is located, (c) Tenant has full corporate, partnership, trust, association or ​ other appropriate power and authority to enter into this Lease and to perform all Tenant’s ​ obligations hereunder, (d) each person (and all of the persons if more than one signs)signing this ​ Lease on behalf of Tenant has the legal capacity and is duly and validly authorized to do so and ​ (e) neither (i) the execution, delivery or performance of this Lease nor (ii) the consummation of ​ the transactions contemplated hereby will violate or conflict with any provision of documents or ​ instruments under which Tenant is constituted or to which Tenant is a party. In addition, Tenant ​ represents and warrants that none of (x) it, (y) its affiliates or partners nor (z) to the best of its ​ knowledge, its members, shareholders or other equity owners or any of their respective ​ employees, officers, directors, representatives or agents is a person or entity with whom U.S. ​ persons or entities are restricted from doing business under regulations of the Office of Foreign ​ ​ 64 ​ Asset Control (“OFAC”) of the Department of the Treasury (including those named on OFAC’s ​ Specially Designated and Blocked Persons List) or under any statute, executive order (including ​ the September 24, 2001, Executive Order Blocking Property and Prohibiting Transactions with ​ Persons Who Commit, Threaten to Commit, or Support Terrorism) or other similar governmental ​ action. ​ ​ 38. Confidentiality. Tenant shall keep the terms and conditions of this Lease and any ​ information provided to Tenant or its employees, agents or contractors pursuant to Article 9 ​ confidential and shall not (a) disclose to any third party any terms or conditions of this Lease or ​ any other Lease-related document (including subleases, assignments, work letters, construction ​ contracts, letters of credit, subordination agreements, non-disturbance agreements, brokerage ​ agreements or estoppels) or (b) provide to any third party an original or copy of this Lease (or ​ any Lease-related document). Landlord shall not release to any third party any non-public ​ financial information or non-public information about Tenant’s ownership structure that Tenant ​ gives Landlord or any non-public information regarding the Clinical Trial provided to Landlord ​ in connection with Section 3.1. Notwithstanding the foregoing, confidential information under ​ this Section may be released by Landlord or Tenant under the following circumstances: (x) if ​ required by Applicable Laws (including, without limitation,as required in order to comply with ​ public filing requirements of the Securities and Exchange Commission) or in any judicial ​ proceeding; provided that the releasing party has given the other party reasonable notice of such ​ requirement, if feasible, (y) to a party’s attorneys, accountants, brokers, lenders, potential ​ lenders, investors, potential investors and other bona fide consultants or advisers (with respect to ​ this Lease only); provided such third parties agree to be bound by this Section or (z) to bona fide ​ prospective assignees or subtenants of this Lease; provided they agree in writing to be bound by ​ this Section. ​ ​ 39. Notices. Except as otherwise stated in this Lease, any notice, consent, demand, invoice, ​ statement or other communication required or permitted to be given hereunder shall be in writing ​ and shall be given by (a) personal delivery, (b) overnight delivery with a reputable international ​ overnight delivery service, such as FedEx, or (c) facsimile or email transmission, so long as such ​ transmission is followed within one (1) business day by delivery utilizing one of the methods ​ described in Subsection 39(a) or (b). Any such notice, consent, demand, invoice, statement or ​ other communication shall be deemed delivered (x) upon receipt, if given in accordance with ​ Subsection 39(a); (y) one (1) business day after deposit with a reputable international overnight ​ delivery service, if given if given in accordance with Subsection 39(b); or (z) upontransmission, ​ if given in accordance with Subsection 39(c). Except as otherwise stated in this Lease, any ​ notice, consent, demand, invoice, statement or other communication required or permitted to be ​ given pursuant to this Lease shall be addressed to Tenant at the Premises, or to Landlord or ​ Tenant at the addresses shown in Sections 2.9 and 2.10 or 2.11, respectively. Either party may, ​ by notice to the other given pursuant to this Section, specify additional or different addresses for ​ notice purposes. ​ ​ 40. Miscellaneous. ​ 40.1. Landlord reserves the right to change the name of the Building or the Project in ​ its sole discretion. ​ ​ 65 ​ 40.2. To induce Landlord to enter into this Lease, Tenant agrees that it shall furnish to ​ Landlord, from time to time, within ten (10) business days after receipt of Landlord’s written ​ request, the most recent year-end unconsolidated financial statements reflecting Tenant’s current ​ financial condition audited by a nationally recognized accounting firm. Tenant shall, within one ​ hundred twenty (120) days after the end of Tenant’s financial year, furnish Landlord with a ​ certified copy of Tenant’s year-end unconsolidated financial statements for the previous year ​ audited by an accounting firm of similar size and reputation to the firm currently used by Tenant ​ (i.e., Squar Milner). Tenant represents and warrants that all financial statements, records and ​ information furnished by Tenant to Landlord in connection with this Lease are true, correct and ​ complete in all respects. If audited financials are not otherwise prepared, unaudited financials ​ complying with generally accepted accounting principles and certified by the chief financial ​ officer of Tenant as true, correct and complete in all respects shall suffice for purposes of this ​ Section. This Section shall not apply so long as Tenant is a publicly traded company and its ​ financial statements are readily available by public means, e.g., the internet. ​ ​ 40.3. Submission of this instrument for examination or signature by Tenant does not ​ constitute a reservation of or option for a lease, and shall not be effective as a lease or otherwise ​ untilexecution by and delivery to both Landlord and Tenant. ​ ​ 40.4. The terms of this Lease are intended by the parties as a final, complete and ​ exclusive expression of their agreement with respect to the terms that are included herein, and ​ may not be contradicted or supplemented by evidence of any other prior or contemporaneous ​ agreement (except by any written agreement executed and delivered by Landlord and Tenant ​ concurrently with the execution and delivery of this Lease). ​ ​ 40.5. Landlord may, but shall not be obligated to, record a short form or memorandum ​ hereof without Tenant’s consent. Tenant will not record a short form or memorandum hereof. ​ Within ten (10) business days after receipt of written request from Landlord, Tenant shall ​ execute a termination of any short form or memorandum of lease recorded with respect hereto. ​ If Landlord elects to record a short form or memorandum of this Lease, Landlord shall be ​ responsible for the cost of recording such short form or memorandum of this Lease, including ​ any transfer or other taxes incurred in connection with such recordation. Neither party shall ​ record this Lease. ​ ​ 40.6. Where applicable in this Lease, the singular includes the plural and the masculine ​ or neuter includes the masculine, feminine and neuter. The words “include,” “includes,” ​ “included” and “including” mean “‘include,’ etc., without limitation.” The word “shall” is ​ mandatory and the word “may” is permissive. The section headings of thisLease are not a part ​ of this Lease and shall have no effect upon the construction or interpretation of any part of this ​ Lease. Landlord and Tenant have each participated in the drafting and negotiation of this Lease, ​ and the language in all parts of this Lease shall be in all cases construed as a whole according to ​ its fair meaning and not strictly for or against either Landlord or Tenant. ​ ​ 40.7. Except as otherwise expressly set forth in this Lease, each party shall pay its own ​ costs and expenses incurred in connection with this Lease and such party’s performance under ​ this Lease; provided that, if either party commences an action, proceeding, demand, claim, ​ action, cause of action or suit against the other party arising out of or in connection with this ​ ​ 66 ​ Lease, then the substantially prevailing party shall be reimbursed by the other party for all ​ reasonable costs and expenses, including reasonable attorneys’ fees and expenses, incurred by ​ the substantially prevailing party in such action, proceeding, demand, claim, action, cause of ​ action or suit, and in any appeal in connection therewith (regardless of whether the applicable ​ action, proceeding, demand, claim, action, cause of action, suit or appeal is voluntarily ​ withdrawn or dismissed). In addition, Landlord shall, upon demand, be entitled to all reasonable ​ attorneys’ fees and all other reasonable costs incurred in the preparation and service of any ​ notice of Default hereunder, regardless of whether a legal action is subsequently commenced, or ​ incurred in connection with any contested matter or other proceeding in bankruptcy court ​ concerning this Lease. ​ ​ ​ Lease. ​ 40.8. Time is of the essence with respect to the performance of every provision of this ​ ​ 40.9. Each provision of this Lease performable by Tenant shall be deemed both a ​ covenant and a condition. ​ ​ 40.10. Notwithstanding anything to the contrary contained in this Lease, Tenant’s ​ obligations under this Lease are independent and shall not be conditioned upon performance by ​ Landlord. ​ ​ 40.11. Whenever consent or approval of either party is required, that party shall not ​ unreasonably withhold, condition or delay such consent or approval, except as maybe expressly ​ set forth to the contrary. ​ ​ 40.12. Any provision of this Lease that shall prove to be invalid, void or illegal shall in ​ no way affect, impair or invalidate any other provision hereof, and all other provisions of this ​ Lease shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal ​ provision did not exist. ​ ​ 40.13. Each of the covenants, conditions and agreements herein contained shall inure to ​ the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; ​ legatees; devisees; executors; administrators; and permitted successors and assigns. This Lease ​ is for the sole benefit of the parties and their respective heirs, legatees, devisees, executors, ​ administrators and permitted successors and assigns, and nothing in this Lease shall give or be ​ construed to give any other person or entity any legal or equitable rights. Nothing in this Section ​ shall in any way alter the provisions of this Lease restricting assignment or subletting. ​ ​ 40.14. This Lease shall be governed by, construed and enforced in accordance with the ​ laws of the state in which the Premises are located, without regard to such state’s conflict of law ​ principles. ​ ​ 40.15. [Intentionally omitted] ​ ​ 40.16. This Lease may be executed in one or more counterparts, each of which, when ​ taken together, shall constitute one and the same document. ​ ​ 67 ​ 40.17. No provision of this Lease may be modified, amended or supplemented except by ​ an agreement in writing signed by Landlord and Tenant. ​ ​ 40.18. No waiver of any term, covenant or condition of this Lease shall be binding upon ​ Landlord unless executed in writing by Landlord. The waiver by Landlord of any breach or ​ default of any term, covenant or condition contained in this Lease shall not be deemed to be a ​ waiver of any preceding or subsequent breach or default of such term, covenant or condition or ​ any other term, covenant or condition of this Lease. ​ ​ 40.19. To the extent permitted by Applicable Laws, the parties waive trial by jury in any ​ action, proceeding or counterclaim brought by the other party hereto related to matters arising ​ out of or in any way connected with this Lease; the relationship between Landlord and Tenant; ​ Tenant’s use or occupancy of the Premises; or any claim of injury or damage related to this ​ Lease or the Premises. ​ ​ 40.20. Subject to compliance with Applicable Laws and Landlord’s prior approval ​ (which approval shall not be unreasonably withheld) of all plans and specifications for such ​ items (which shall be installed either as an Alteration or as part of the initial Tenant ​ Improvements), Landlord will permit Tenant to install and operate (a) a kitchen within the ​ Premises containing a stove, oven, sink and any other reasonably related fixtures and appliances, ​ and (b) a barbecue grill at a locationreasonably approved by Landlord, in each case for use by ​ Tenant’s employees and occasional use for company functions of Tenant at the Premises. ​ Tenant will be responsible for performing commercially reasonable repair and maintenance with ​ respect to the items listed in Subsections (a) and (b) above and will otherwise comply with any ​ reasonable requirements of Landlord with respect to the maintenance of such items. ​ ​ 41. [Intentionally omitted] ​ ​ 42. Option to Extend Term. Tenant shall have one (1) option (”Option”) to extend the Term ​ by five (5) years as to the entire Premises (and no less than the entire Premises) upon the ​ following terms and conditions. Any extension of the Term pursuant to the Option shall be on ​ all the same terms and conditions as this Lease, except as follows: ​ ​ 42.1. Base Rent at the commencement of the Option term shall equal the then-current ​ fair market value for comparable office and laboratory space in the UTC submarket of ​ comparable age, quality, level of finish and proximity to amenities and public transit, and ​ containing the systems and improvements present in the Premises as of the date that Tenant gives ​ Landlord written notice of Tenant’s election to exercise the Option (“FMV”), and shall be ​ further increased on each annual anniversary of the Option term commencement date by three ​ percent (3%). Tenant may, no more than fifteen (15) months prior to the date the Term is then ​ scheduled to expire, requestLandlord’s estimate of the FMV for the Option term. Landlord ​ shall, within fifteen (15) days after receipt of such request, give Tenant a written proposal of ​ such FMV. If Tenant gives written notice to exercise the Option, such notice shall specify ​ whether Tenant accepts Landlord’s proposed estimate of FMV. If Tenant does not accept the ​ FMV, then the parties shall endeavor to agree upon the FMV, taking into account all relevant ​ factors, including (a) the size of the Premises, (b) the length of the Option term, (c) rent in ​ comparable buildings in the relevant submarket, including concessions offered to new tenants, ​ ​ 68 ​ such as free rent, tenant improvement allowances and moving allowances, (d) Tenant’s ​ creditworthiness and (e) the quality and location of the Building and the Project. In the event ​ that the parties are unable to agree upon the FMV within thirty (30) days after Tenant notifies ​ Landlord that Tenant is exercising the Option, then either party may request that the same be ​ determined as follows: a senior officer of a nationally recognized leasing brokerage firm with ​ local knowledge of the UTC laboratory/research and development leasing submarket (the ​ “Baseball Arbitrator”) shall be selected and paid for jointly by Landlord and Tenant. If Landlord ​ and Tenant are unable to agree upon the Baseball Arbitrator, then the same shall be designated ​ by the local chapter of the Judicial Arbitration and Mediation Services or any successor ​ organization thereto (the “JAMS”). The Baseball Arbitrator selected by the parties or designated ​ by JAMS shall (y) have at least ten (10) years’ experience in the leasing of laboratory/research ​ and development space in the UTC submarket and (z) not have been employed or retained by ​ either Landlord or Tenant or any affiliate of either for a period of at least ten (10) years prior to ​ appointment pursuant hereto. Each of Landlord and Tenant shall submit to the Baseball ​ Arbitrator and to the other party its determination of the FMV. The Baseball Arbitrator shall ​ grant to Landlord and Tenant a hearing and the right to submit evidence. The Baseball ​Arbitrator shall determine which of the two (2) FMV determinations more closely represents the ​ actual FMV. The arbitrator may not select any other FMV for the Premises other than one ​ submitted by Landlord or Tenant. The FMV selected by the Baseball Arbitrator shall be binding ​ upon Landlord and Tenant and shall serve as the basis for determination of Base Rent payable ​ for the Option term. If, as of the commencement date of the Option term, the amount of Base ​ Rent payable during the Option term shall not have been determined, then, pending such ​ determination, Tenant shall pay Base Rent equal to the Base Rent payable with respect to the last ​ year of the then-current Term. After the final determination of Base Rent payable for the Option ​ term, the parties shall promptly execute a written amendment to this Lease specifying the amount ​ of Base Rent to be paid during the Option term. Any failure of the parties to execute such ​ amendment shall not affect the validity of the FMV determined pursuant to this Section. ​ ​ 42.2. The Option is not assignable separate and apart from this Lease. ​ ​ 42.3. The Option is conditional upon Tenant giving Landlord written notice of its ​ election to exercise the Option not more than fifteen (15) months and not less than twelve (12) ​ months prior to the end of the expiration of the then-current Term. Time shall be of the essence ​ as to Tenant’s exercise of the Option. Tenant assumes full responsibility for maintaining a ​ record of the deadlines toexercise the Option. Tenant acknowledges that it would be inequitable ​ to require Landlord to accept any exercise of the Option after the date provided for in this ​ Section. ​ ​ 42.4. Notwithstanding anything contained in this Article to the contrary, Tenant shall ​ not have the right to exercise the Option: ​ ​ (a) During the time commencing from the date Landlord delivers to Tenant a ​ written notice that Tenant is in default under any provisions of this Lease and continuing until ​ Tenant has cured the specified default to Landlord’s reasonable satisfaction; or ​ ​ (b) At any time after any Default as described in Article 31 of the Lease and ​ continuing until Tenant cures any such Default, if such Default is susceptible to being cured; or ​ ​ 69 ​ (c) In the event that Landlord has delivered to Tenant notice two (2) or more ​ times during the twelve (12)-month period immediately prior to the date that Tenant intends to ​ exercise the Option, that Tenant is in monetary or material non-monetary default in the ​ performance of its obligations hereunder, whether or not Tenant has cured such defaults. ​ ​ 42.5. The period of time within which Tenant may exercise the Option shall not be ​ extended or enlarged by reason of Tenant’s inability to exercise such Option because of the ​ provisions of Section 42.4. ​ ​ 42.6. All of Tenant’s rights under the provisions of the Option shall terminate and be of ​ no further force or effect even after Tenant’s due and timely exercise of the Option if, after such ​ exercise, but prior to the commencement date of the new term, (a) Tenant fails to pay to ​ Landlord a monetary obligation of Tenant for a period of twenty (20) days after written notice ​ from Landlord to Tenant, (b) Tenant fails to commence to cure a default (other than a monetary ​ default) within thirty (30) days after the date Landlord gives notice to Tenant of such default or ​ (c) Tenant has defaulted under this Lease three (3) or more times and a service or late charge ​ under Section 31.1 has become payable for any such default, whether or not Tenant has cured ​ such defaults. ​ ​ 43. Rooftop Access. Landlord hereby grants to Tenant the Rooftop License (as defined in ​ Exhibit K) subject to the terms and conditions set forth in Exhibit K attached hereto. Tenant ​acknowledges that the rooftop of the Building is currently subject to a lease (the “Rooftop ​ Lease”) with Global Tower, LLC (together with its successors, assigns, subtenants and licensees, ​ “Global”). Notwithstanding anything to the contrary in this Lease, Tenant acknowledges and ​ agrees that Tenant shall, upon prior notice, provide Global with access to the Building ​ (including, without limitation, the Building rooftop) at all times to exercise Global’s rights under ​ the Rooftop Lease, including installation of any equipment permitted to be installed pursuant to ​ the Rooftop Lease (provided, however, that Tenant shall be permitted to require that a ​ representative of Tenant accompany Global during any such access). ​ ​ [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] ​ ​ ​ IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the date first ​ above written. ​ ​ LANDLORD: ​ ​ BMR-AXIOM LP, ​ a Delaware limited partnership ​ ​ ​ By: ​ Name: ​ Title: ​ ​ ​ ​ TENANT: ​ ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ ​ ​ By: ​ Name: ​ Title: ​ ​ A-1-1 ​ EXHIBIT A ​ PREMISES ​ ​ MCFARLANE ​ ARCHITECTS ​ SCALE: 1" = 20'-0" X:\MA_Projects\16-184-01_LJPC\CAD\10_Archive\00_MA Clean Backgrounds\4550_1st floor.dwg 1272016 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ 4550 TOWNE CENTRE COURT - FIRST FLOOR PLAN ​ N​ ​ ELEV. ​ MACHINE ​ 107.2 ​ ELEV ​ ​ ​ ​ ​ FI RE ​ RM. ​ LAB ​ UTILITY ​ 107.1 ​ COMMON ​ SHIPPING ​ RECEIVING ​ 107 ​ SDG&E ​ 109 ​ FUTURE COMMON ​ SPACE ​ 130 ​ FUTURE ​ TENANT SPACE ​ 140 ​ STAIRS ​ S103 ​ ELECT. ​ 108 ​ UP ​ MEN ​ 102 ​ JAN. ​ 103 ​ ELEV ​ MACHINE ​ ROOM ​ 103.1 ​ STORAGE ​ 104 ​ MPOE ​ 105 ​ ELEV ​ WOMEN ​ 101 ​ STAIRS ​ S102 ​ ELEV ​ 1 ​ FUTURE ​ TENANT SPACE ​ 120 ​ STAIRS ​ S101 ​ RI​ SE​ R ​ U​ P​ ​ U​ P​ ​ ​ MCFARLANE ​ ARCHITECTS ​ SCALE: 1" = 20'-0" X:\MA_Projects\16-184-01_LJPC\CAD\10_Archive\00_MA Clean Backgrounds\4550_2nd floor.dwg 1272016 ​ ELEV ​ 3 ​ FUTURE ​ TENANT SPACE ​ 230 ​ ELECTRICAL ​ 206 ​ IT ​ 207 FUTURE ​ TENANT SPACE ​ 240 ​ STAIRS ​ S203 ​ UP ​ MEN ​ 202 ​ JANITOR ​ 203 ​ STORAGE ​ 205 ​ STORAGE ​ 204 ​ ELEV. ​ LOBBY ​ 200 ​ ELEV ​ 2 ​ STAIRS ​ S202 ​ ELEV ​ WOMEN ​ 201 ​ FS ​ FUTURE ​ TENANT SPACE ​ 220 ​ STAIRS ​ S201 ​ FI​ R​ E ​ RI​ SE​ R ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ U​ P​ ​ U​ P​ ​ ​ MCFARLANE ​ ARCHITECTS ​ SCALE: 1" = 20'-0" X:\MA_Projects\16-184-01_LJPC\CAD\10_Archive\00_MA Clean Backgrounds\4550_2nd floor.dwg 1272016 ​ 4550 TOWNE CENTRE COURT - SECOND FLOOR PLAN ​ N​ ​ ​ MCFARLANE ​ ARCHITECTS ​ SCALE: 1" = 20'-0" X:\MA_Projects\16-184-01_LJPC\CAD\10_Archive\00_MA Clean Backgrounds\4550_3rd floor.dwg 1272016 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ 4550 TOWNE CENTRE COURT - THIRD FLOOR PLAN ​ N​ ​ 330 340 ​ ELEV ​ 3 ​ S303 ​ FUTURE ​ TENANT SPACE ​ ELECTRICAL ​ 306 ​ IT ​ 307 FUTURE ​ TENANT SPACE ​ STAIRS ​ DN ​ MEN ​ 302 ​ JAN. ​ 303 ​ STORAGE ​ 305 ​ STORAGE ​ 304 ​ LOBBY ​ 300 ​ ELEV ​ STAIRS ​ S302 ​ ELEV ​ 1 ​ WOMEN ​ 301 ​ FUTURE ​ TENANT SPACE ​ 320 ​ STAIRS ​ S301 ​ FI​ R​ E ​ RI​ SE​ R ​ D​ N​ ​ D​ N​ ​ ​ B-1 ​ EXHIBIT B ​ WORK LETTER ​ This Work Letter (this “Work Letter”) is made and entered into as of the day of December, ​ 2016, by and between BMR-AXIOM LP, a Delaware limited partnership (“Landlord”), and LA ​ JOLLA PHARMACEUTICAL COMPANY, a California corporation (“Tenant”), and is attached ​ to and made a part of that certain Lease dated as of December , 2016 (as the same may be ​ amended, amended and restated, supplemented or otherwise modified from time to time, the ​ “Lease”), by and between Landlord and Tenant for the Premises located at 4550 Towne Centre ​ Court, San Diego, California. All capitalized terms used but not otherwise defined herein shall ​ have the meanings given them in the Lease. ​ ​ 1. General Requirements. ​ ​ 1.1. Authorized Representatives. ​ ​ (a) Landlord designates, as Landlord’s authorized representative (“Landlord’s ​ Authorized Representative”), (i) Federico Mina as the person authorized to initial plans, ​ drawings, approvals and to sign change orders pursuant to this Work Letter and (ii) an officer of ​ Landlord as the person authorized to sign any amendments to this Work Letter or the Lease. ​ Tenant shall not be obligated to respond to or act upon any such item until such item has been ​ initialed or signed (as applicable) by the appropriate Landlord’s Authorized Representative. ​ Landlord may change Landlord’s Authorized Representative upon one (1) business day’s prior ​ written notice to Tenant. Landlord’sAuthorized Representative and a representative of ​ Landlord’s lender will have access to the Premises at all times during the construction of the ​ Tenant Improvements, and if requested by Landlord, Tenant’s Authorized Representative will be ​ present during any site visit at a mutually agreed time. ​ ​ (b) Tenant designates Niklas Bandak (“Tenant’s Authorized Representative”) ​ as the person authorized to initial and sign all plans, drawings, change orders and approvals ​ pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any such ​ item until such item has been initialed or signed (as applicable) by Tenant’s Authorized ​ Representative. Tenant may change Tenant’s Authorized Representative upon one (1) business ​ day’s prior written notice to Landlord. ​ ​ 1.2. Schedule. The schedule for design and development of the Tenant Improvements, ​ including the time periods for preparation and review of construction documents, approvals and ​ performance, shall be in accordance with a schedule to be prepared by Tenant (the “Schedule”). ​ Tenant shall prepare the Schedule so that it is a reasonable schedule for the completion of the ​ Tenant Improvements. The Schedule shall clearly identify all activities requiring Landlord ​ participation, including specific dates and time periods when Tenant’s contractor will require ​ access to areas of the Project outside of the Premises. As soon as the Schedule iscompleted, ​ Tenant shall deliver the same to Landlord for Landlord’s approval, which approval shall not be ​ unreasonably withheld, conditioned or delayed. Such Schedule shall be approved or disapproved ​ by Landlord within ten (10) business days after delivery to Landlord. Landlord’s failure to ​ respond within such ten (10) business day period shall be deemed approval by Landlord. If ​ ​ B-2 ​ Landlord disapproves the Schedule, then Landlord shall notify Tenant in writing of its objections ​ to such Schedule, and the parties shall confer and negotiate in good faith to reach agreement on ​ the Schedule. The Schedule shall be subject to adjustment as mutually agreed upon in writing by ​ the parties, or as provided in this Work Letter. ​ ​ 1.3. Tenant’s Architects, Contractors and Consultants. The architect, engineering ​ consultants, design team, general contractor and subcontractors responsible for the construction ​ of the Tenant Improvements shall be selected by Tenant and approved by Landlord in ​ accordance with Section 4.7 of the Lease. Landlord may refuse to use any architects, ​ consultants, contractors, subcontractors or material suppliers that Landlord reasonably believes ​ could cause labor disharmony or may not have sufficient experience, in Landlord’s reasonable ​ opinion, to perform work in an occupied Class “A” laboratory research building and in lab areas. ​ All Tenant contracts related to the Tenant Improvements shall provide that Tenant may assign ​ such contracts and any warranties with respect to the Tenant Improvements to Landlord at any ​ time and a copy of all such contracts will be provided to Landlord (including any contracts ​ between the general contractor and any subcontractors performing work in excess of $100,000). ​ ​ 2. Tenant Improvements. All Tenant Improvements shall beperformed by Tenant’s ​ contractor, at Tenant’s sole cost and expense (subject to Landlord’s obligations with respect to ​ payment of the Base TI Allowance and, if properly requested by Tenant pursuant to the terms of ​ the Lease, the Additional TI Allowance) and in accordance with the Approved Plans (as defined ​ below), the Lease and this Work Letter. To the extent that the total projected cost of the Tenant ​ Improvements (as projected by Landlord) exceeds the TI Allowance (such excess, the “Excess ​ TI Costs”), Tenant shall pay the costs of the Tenant Improvements on a pari passu basis with ​ Landlord as such costs become due, in the proportion of Excess TI Costs payable by Tenant to ​ the Base TI Allowance (and, if properly requested by Tenant pursuant to the Lease, the ​ Additional TI Allowance). If the cost of the Tenant Improvements (as projected by Landlord) ​ increases over Landlord’s initial projection, then Landlord may notify Tenant and Tenant shall ​ pay any additional Excess TI Costs in the same way that Tenant paid the initial Excess TI Costs. ​ If Tenant fails to pay, or is late in paying, any sum due to Landlord under this Work Letter, then ​ after notice and the expiration of a ten (10) business day cure period, Landlord shall have all of ​ the rights and remedies set forth in the Lease for nonpayment of Rent (including the right to ​ interest and the right to assess a late charge), and for purposes of any litigation instituted with ​ regard to suchamounts the same shall be considered Rent. All material and equipment furnished ​ by Tenant or its contractors as the Tenant Improvements shall be new or “like new;” the Tenant ​ Improvements shall be performed in a first-class, workmanlike manner; and the quality of the ​ Tenant Improvements shall be of a nature and character not less than the Building Standard. ​ Tenant shall take, and shall require its contractors to take, commercially reasonable steps to ​ protect the Premises during the performance of any Tenant Improvements, including covering or ​ temporarily removing any window coverings so as to guard against dust, debris or damage. All ​ Tenant Improvements shall be performed in accordance with Article 17 of the Lease; provided ​ that, notwithstanding anything in the Lease or this Work Letter to the contrary, in the event of a ​ conflict between this Work Letter and Article 17 of the Lease, the terms of this Work Letter shall ​ govern. ​ ​ B-3 ​ 2.1. Work Plans. Tenant shall prepare and submit to Landlord for approval ​ schematics covering the Tenant Improvements prepared in conformity with the applicable ​ provisions of this Work Letter (the “Draft Schematic Plans”). The Draft Schematic Plans shall ​ contain sufficient information and detail to accurately describe the proposed design to Landlord ​ and such other information as Landlord may reasonably request. Landlord shall notify Tenant in ​ writing within five (5) business days after receipt of the Draft Schematic Plans whether Landlord ​ approves or objects to the Draft Schematic Plans and of the manner, if any, in which the Draft ​ Schematic Plans are unacceptable. Landlord’s failure to respond within such five (5) business ​ day period shall be deemed approval by Landlord. If Landlord reasonably objects to the Draft ​ Schematic Plans, then Tenant shall revise the Draft Schematic Plans and cause Landlord’s ​ objections to be remedied in the revised Draft Schematic Plans. Tenant shall then resubmit the ​ revised Draft Schematic Plans to Landlord for approval, such approval not to be unreasonably ​ withheld, conditioned or delayed. Landlord’s approval of or objection to revised Draft ​ Schematic Plans and Tenant’s correction of the same shall be in accordance with this Section ​ until Landlord has approved the Draft Schematic Plans in writing or been deemed to have ​ approved them. The iteration of the Draft Schematic Plans that isapproved or deemed approved ​ by Landlord without objection shall be referred to herein as the “Approved Schematic Plans.” ​ ​ 2.2. Construction Plans. Tenant shall prepare final plans and specifications for the ​ Tenant Improvements that (a) are consistent with and are logical evolutions of the Approved ​ Schematic Plans and (b) incorporate any other Tenant-requested (and Landlord-approved) ​ Changes (as defined below). As soon as such final plans and specifications (“Construction ​ Plans”) are completed, Tenant shall deliver the same to Landlord for Landlord’s approval, which ​ approval shall not be unreasonably withheld, conditioned or delayed. All such Construction ​ Plans shall be submitted by Tenant to Landlord in electronic .pdf, CADD and full-size hard copy ​ formats, and shall be approved or disapproved by Landlord within ten (10) business days after ​ delivery to Landlord. Landlord’s failure to respond within such ten (10) business day period ​ shall be deemed approval by Landlord. If the Construction Plans are disapproved by Landlord ​ (which disapproval shall be limited to items which are different from, or which are not logical ​ evolutions of the Approved Schematic Plans), then Landlord shall notify Tenant in writing of its ​ objections to such Construction Plans, and the parties shall confer and negotiate in good faith to ​ reach agreement on the Construction Plans. At the same time as Tenant’s architect submits the ​ ConstructionPlans to the City for approval, Tenant will submit two (2) copies of such ​ Construction Plans to Landlord. In the event Landlord has any changes to the Construction ​ Plans (as permitted under this Section), Tenant will cause the Construction Plans submitted to ​ the City to be revised and resubmitted as required to incorporate such changes into the final ​ Construction Plans. The Construction Plans so approved, and all change orders specifically ​ permitted by this Work Letter, are referred to herein as the “Approved Plans.” ​ ​ 2.3. Changes to the Tenant Improvements. Any changes to the Approved Plans (each, ​ a “Change”) shall be requested and instituted in accordance with the provisions of this Article 2 ​ and shall be subject to the written approval of the non-requesting party in accordance with this ​ Work Letter. ​ ​ (a) Change Request. Either Landlord or Tenant may request Changes after ​ Landlord approves the Approved Plans by notifying the other party thereof in writing in ​ ​ B-4 ​ substantially the same form as the AIA standard change order form (a “Change Request”), which ​ Change Request shall detail the nature and extent of any requested Changes, including (a) the ​ Change, (b) the party required to perform the Change and (c) any modification of the Approved ​ Plans and the Schedule, as applicable, necessitated by the Change. If the nature of a Change ​ requires revisions to the Approved Plans, then the requesting party shall be solely responsible for ​ the cost and expense of such revisions and any increases in the cost of the Tenant Improvements ​ as a result of such Change. Change Requests shall be signed by the requesting party’s ​ Authorized Representative. ​ ​ (b) Approval of Changes. All Change Requests shall be subject to the other ​ party’s prior written approval, which approval shall not be unreasonably withheld, conditioned ​ or delayed. The non-requesting party shall have five (5) business days after receipt of a Change ​ Request to notify the requesting party in writing of the non-requesting party’s decision either to ​ approve or object to the Change Request. The non-requesting party’s failure to respond within ​ such five (5) business day period shall be deemed approval by the non-requesting party. ​ ​ 2.4. Preparation of Estimates. Tenant shall, before proceeding with any Change, using ​ its best efforts, prepare as soon as is reasonably practicable (but in no event more than five (5) ​business days after delivering a Change Request to Landlord or receipt of a Change Request) an ​ estimate of the increased costs or savings that would result from such Change, as well as an ​ estimate of such Change’s effects on the Schedule. Landlord shall have five (5) business days ​ after receipt of such information from Tenant to (a) in the case of a Tenant-initiated Change ​ Request, approve or reject such Change Request in writing, or (b) in the case of a Landlord- ​ initiated Change Request, notify Tenant in writing of Landlord’s decision either to proceed with ​ or abandon the Landlord-initiated Change Request. ​ ​ 2.5. Quality Control Program; Coordination. Tenant shall provide Landlord with ​ information regarding the following (together, the “QCP”): (a) Tenant’s general contractor’s ​ quality control program and (b) evidence of subsequent monitoring and action plans. The QCP ​ shall be subject to Landlord’s reasonable review and approval and shall specifically address the ​ Tenant Improvements. Tenant shall ensure that the QCP is regularly implemented on a ​ scheduled basis and shall provide Landlord with reasonable prior notice and access to attend all ​ inspections and meetings between Tenant and its general contractor. At the conclusion of the ​ Tenant Improvements, Tenant shall deliver the quality control log to Landlord, which shall ​ include all records of quality control meetings and testing and of inspections held in the field, ​including inspections relating to concrete, steel roofing, piping pressure testing and system ​ commissioning. ​ ​ 3. Completion of Tenant Improvements. Tenant, at its sole cost and expense (except for the ​ Base TI Allowance and, if properly requested by Tenant pursuant to the terms of the Lease, the ​ Additional TI Allowance), shall perform and complete the Tenant Improvements in all respects ​ (a) in substantial conformance with the Approved Plans, (b) otherwise in compliance with ​ provisions of the Lease and this Work Letter and (c) in accordance with Applicable Laws, the ​ requirements of Tenant’s insurance carriers, the requirements of Landlord’s insurance carriers ​ (to the extent Landlord provides its insurance carriers’ requirements to Tenant) and the board of ​ fire underwriters having jurisdiction over the Premises. The Tenant Improvements shall be ​ ​ B-5 ​ deemed completed at such time as Tenant shall furnish to Landlord (t) evidence satisfactory to ​ Landlord that (i) all Tenant Improvements have been completed and paid for in full (which shall ​ be evidenced by the architect’s certificate of completion and the general contractor’s and each ​ subcontractor’s and material supplier’s final unconditional waivers and releases of liens, each in ​ a form acceptable to Landlord and complying with Applicable Laws, and a Certificate of ​ Substantial Completion in the form of the American Institute of Architects document G704, ​ executed by the project architect and the general contractor, together with a statutory notice of ​ substantial completion from the general contractor), (ii) all Tenant Improvements have been ​ accepted by Landlord, (iii) any and all liens related to the Tenant Improvements have either been ​ discharged of record (by payment, bond, order of a court of competent jurisdiction or otherwise) ​ or waived by the party filing such lien and (iv) no security interests relating to the Tenant ​ Improvements are outstanding, (u) all certifications and approvals with respect to the Tenant ​ Improvements that may be required from any Governmental Authority and any board of fire ​ underwriters or similar body for the use and occupancy of the Premises (including a certificate of ​ occupancy (or its substantial equivalent) for the Premises for the Permitted Use), (v) certificates ​ of insurance required by the Lease to be purchased and maintained byTenant, (w) an affidavit ​ from Tenant’s architect certifying that all work performed in, on or about the Premises is in ​ accordance with the Approved Plans, (x) complete “as built” drawing print sets, project ​ specifications and shop drawings and electronic CADD files on disc (showing the Tenant ​ Improvements as an overlay on the Building “as built” plans (provided that Landlord provides ​ the Building “as-built” plans provided to Tenant) of all contract documents for work performed ​ by their architect and engineers in relation to the Tenant Improvements, (y) a commissioning ​ report prepared by a licensed, qualified commissioning agent hired by Tenant and approved by ​ Landlord for all new or affected mechanical, electrical and plumbing systems (which report ​ Landlord may hire a licensed, qualified commissioning agent to peer review, and whose ​ reasonable recommendations Tenant’s commissioning agent shall perform and incorporate into a ​ revised report) and (z) such other “close out” materials as Landlord reasonably requests ​ consistent with Landlord’s own requirements for its contractors or which are required by ​ Landlord’s lender, such as copies of manufacturers’ warranties, operation and maintenance ​ manuals and the like. In connection with Tenant’s performance of the Tenant Improvements, ​ Tenant will keep a log for all of the following categories in connection with the Tenant ​ Improvements: change orders, requests for information and lienreleases, and will keep and ​ maintain a copy of the minutes from weekly construction meetings, a list of all subcontractors ​ (including contract amounts) working on the Tenant Improvements, as well as an up to date ​ Schedule and Approved Budget (as defined below) and will make the foregoing items available ​ to Landlord as part of each Fund Request or as otherwise requested by Landlord. ​ ​ 4. Insurance. ​ ​ 4.1. Property Insurance. At all times during the period beginning with ​ commencement of construction of the Tenant Improvements and ending with final completion of ​ the Tenant Improvements, Tenant shall maintain, or cause to be maintained (in addition to the ​ insurance required of Tenant pursuant to the Lease), property insurance naming Landlord and the ​ Landlord Parties as additional insureds. Such policy shall, on a completed values basis for the ​ full insurable value at all times, insure against loss or damage by fire, vandalism and malicious ​ mischief and other such risks as are customarily covered by the so-called “broad form extended ​ ​ B-6 ​ coverage endorsement” upon all Tenant Improvements and the general contractor’s and any ​ subcontractors’ machinery, tools and equipment, all while each forms a part of, or is contained ​ in, the Tenant Improvements or any temporary structures on the Premises, or is adjacent thereto; ​ provided that, for the avoidance of doubt, insurance coverage with respect to the general ​ contractor’s and any subcontractors’ machinery, tools and equipment shall be carried on a ​ primary basis by such general contractor or the applicable subcontractor(s). Tenant agrees to ​ pay any deductible, and Landlord is not responsible for any deductible, for a claim under such ​ insurance. Such property insurance shall contain an express waiver of any right of subrogation ​ by the insurer against Landlord and the Landlord Parties, and shall name Landlord and its ​ affiliates as loss payees as their interests may appear. ​ ​ 4.2. Workers’ Compensation Insurance. At all times during the period of construction ​ of the Tenant Improvements, Tenant shall, or shall cause its contractors or subcontractors to, ​ maintain statutory workers’ compensation insurance as required by Applicable Laws. ​ ​ 5. Liability. Tenant assumes sole responsibility and liability for any and all injuries or the ​ death of any persons, including Tenant’s contractors and subcontractors and their respective ​ employees, agents and invitees, and for any and all damages to property caused by,resulting ​ from or arising out of any act or omission on the part of Tenant, Tenant’s contractors or ​ subcontractors, or their respective employees, agents and invitees in the prosecution of the ​ Tenant Improvements. Tenant agrees to Indemnify the Landlord Indemnitees from and against ​ all Claims due to, because of or arising out of any and all such injuries, death or damage, ​ whether real or alleged, and Tenant and Tenant’s contractors and subcontractors shall assume ​ and defend at their sole cost and expense all such Claims; provided, however, that nothing ​ contained in this Work Letter shall be deemed to Indemnify Landlord from or against liability ​ caused by Landlord’s negligence or willful misconduct. Any deficiency in design or ​ construction of the Tenant Improvements shall be solely the responsibility of Tenant, ​ notwithstanding the fact that Landlord may have approved of the same in writing. ​ ​ 6. TI Allowance. ​ ​ 6.1. Application of TI Allowance. Landlord shall contribute, in the following order, ​ the Base TI Allowance and, if properly requested by Tenant pursuant to the terms of the Lease, ​ the Additional TI Allowance toward the costs and expenses incurred in connection with the ​ performance of the Tenant Improvements, in accordance with Article 4 of the Lease. If the ​ entire TI Allowance is not applied toward or reserved for the costs of the Tenant Improvements, ​ then Tenant shall not be entitled to a credit of such unused portion of the TI Allowance.Tenant ​ may apply the Base TI Allowance and, if properly requested by Tenant pursuant to the terms of ​ the Lease, the Additional TI Allowance for the payment of construction and other costs in ​ accordance with the terms and provisions of the Lease. ​ ​ 6.2. Approval of Budget for the Tenant Improvements. Notwithstanding anything to ​ the contrary set forth elsewhere in this Work Letter or the Lease, Landlord shall not have any ​ obligation to expend any portion of the TI Allowance until Landlord and Tenant shall have ​ approved in writing the budget for the Tenant Improvements (the “Approved Budget”). Prior to ​ Landlord’s approval of the Approved Budget, Tenant shall pay all of the costs and expenses ​ incurred in connection with the Tenant Improvements as they become due. Landlord shall not be ​ ​ B-7 ​ obligated to reimburse Tenant for costs or expenses relating to the Tenant Improvements that ​ exceed the amount of the TI Allowance. Landlord shall not unreasonably withhold, condition or ​ delay its approval of any budget for Tenant Improvements that is proposed by Tenant. ​ ​ 6.3. Fund Requests. Upon submission by Tenant to Landlord (which submittals must ​ be provided on or before the first (1st) day of each month starting in the first month that Tenant is ​ eligible to request payment of the TI Allowance) of (a) a statement (a “Fund Request”) setting ​ forth the total amount of the TI Allowance requested, (b) a summary of the Tenant ​ Improvements performed using AIA standard form Application for Payment (G 702) executed ​ by the general contractor and by the architect, (c) invoices from the general contractor, the ​ architect, and any subcontractors, material suppliers and other parties requesting payment with ​ respect to the amount of the TI Allowance then being requested, (d) unconditional lien releases ​ from the general contractor and each subcontractor and material supplier with respect to previous ​ payments made by either Landlord or Tenant for the Tenant Improvements in a form acceptable ​ to Landlord and complying with Applicable Laws, (e) conditional lien releases from the general ​ contractor and each subcontractor and material supplier with respect to the Tenant Improvements ​ performed that correspond to the Fund Request each in a formacceptable to Landlord and ​ complying with Applicable Laws, (f) all information required by the last sentence of Section 3 ​ above, (g) copies of all change orders issued in the applicable payment period, and (h) any other ​ documentation required by Landlord’s lender as a condition to funding of loan proceeds, then ​ Landlord shall, within thirty (30) days following receipt by Landlord of a Fund Request and the ​ accompanying materials required by this Section, pay to (as elected by Landlord) the applicable ​ contractors, subcontractors and material suppliers or Tenant (for reimbursement for payments ​ made by Tenant to such contractors, subcontractors or material suppliers either prior to ​ Landlord’s approval of the Approved TI Budget or as a result of Tenant’s decision to pay for the ​ Tenant Improvements itself and later seek reimbursement from Landlord in the form of one lump ​ sum payment in accordance with the Lease and this Work Letter), the amount of Tenant ​ Improvement costs set forth in such Fund Request; provided, however, that Landlord shall not be ​ obligated to make any payments under this Section until the budget for the Tenant Improvements ​ is approved in accordance with Section 6.2, and any Fund Request under this Section shall be ​ subject to the payment limits set forth in Section 6.2 above and Article 4 of the Lease. ​ Notwithstanding anything in this Section to the contrary, Tenant shall not submit a Fund Request ​ more oftenthan every thirty (30) days and may not submit a Fund Request until the Clinical ​ Trial Termination Option has expired or is void and of no further effect. Any additional Fund ​ Requests submitted by Tenant shall be void and of no force or effect. ​ ​ 6.4. Accrual Information. In addition to the other requirements of this Section 6, ​ Tenant shall, no later than the third (3rd) business day of each month until the Tenant ​ Improvements are complete, provide Landlord with an estimate of (a) the percentage of design ​ and other soft cost work that has been completed, (b) design and other soft costs spent through ​ the end of the previous month, both from commencement of the Tenant Improvements and solely ​ for the previous month, (c) the percentage of construction and other hard cost work that has been ​ completed, (d) construction and other hard costs spent through the end of the previous month, ​ both from commencement of the Tenant Improvements and solely for the previous month, and ​ (e) the date of Substantial Completion of the Tenant Improvements. ​ ​ B-8 ​ 7. Miscellaneous. ​ ​ 7.1. Incorporation of Lease Provisions. Sections 40.6 through 40.19 of the Lease are ​ incorporated into this Work Letter by reference, and shall apply to this Work Letter in the same ​ way that they apply to the Lease. ​ ​ 7.2. General. Except as otherwise set forth in the Lease or this Work Letter, this Work ​ Letter shall not apply to improvements performed in any additional premises added to the ​ Premises at any time or from time to time, whether by any options under the Lease or otherwise; ​ or to any portion of the Premises or any additions to the Premises in the event of a renewal or ​ extension of the original Term, whether by any options under the Lease or otherwise, unless the ​ Lease or any amendment or supplement to the Lease expressly provides that such additional ​ premises are to be delivered to Tenant in the same condition as the initial Premises. ​ ​ ​ [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] ​ ​ B-9 ​ IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter to be ​ effective on the date first above written. ​ ​ LANDLORD: ​ ​ BMR-AXIOM LP, ​ a Delaware limited partnership ​ ​ ​ By: ​ Name: ​ Title: ​ ​ ​ TENANT: ​ ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ ​ ​ By: ​ Name: ​ Title: ​ ​ B-1-1 ​ EXHIBIT B-1 ​ ​ TENANT WORK INSURANCE SCHEDULE ​ ​ Tenant shall be responsible for requiring all of Tenant contractors doing construction or ​ renovation work to purchase and maintain such insurance as shall protect it from the claims set ​ forth below which may arise out of or result from any Tenant Work whether such Tenant Work ​ is completed by Tenant or by any Tenant contractors or by any person directly or indirectly ​ employed by Tenant or any Tenant contractors, or by any person for whose acts Tenant or any ​ Tenant contractors may be liable: ​ ​ 1. Claims under workers’ compensation, disability benefit and other similar employee ​ benefit acts which are applicable to the Tenant Work to be performed. ​ ​ 2. Claims for damages because of bodily injury, occupational sickness or disease, or death ​ of employees under any applicable employer’s liability law. ​ ​ 3. Claims for damages because of bodily injury, or death of any person other than Tenant’s ​ or any Tenant contractors’ employees. ​ ​ 4. Claims for damages insured by usual personal injury liability coverage which are ​ sustained (a) by any person as a result of an offense directly or indirectly related to the ​ employment of such person by Tenant or any Tenant contractors or (b) by any other person. ​ ​ 5. Claims for damages, other than to the Tenant Work itself, because of injury to or ​ destruction of tangible property, including loss of use therefrom. ​ ​ 6. Claims for damages because of bodily injuryor death of any person or property damage ​ arising out of the ownership, maintenance or use of any motor vehicle. ​ ​ Tenant contractors’ Commercial General Liability Insurance shall include ​ premises/operations (including explosion, collapse and underground coverage if such Tenant ​ Work involves any underground work), elevators, independent contractors, products and ​ completed operations, and blanket contractual liability on all written contracts, all including ​ broad form property damage coverage. ​ ​ Tenant contractors’ Commercial General, Automobile, Employers and Umbrella Liability ​ Insurance shall be written for not less than limits of liability as follows: ​ ​ a. Commercial General Liability: ​ ​ Bodily Injury and Property ​ Damage ​ Commercially reasonable amounts, but ​ in any event no less than $1,000,000 per ​ occurrence and $2,000,000 general ​ aggregate, with $2,000,000 products and ​ completed operations aggregate. ​ ​ B-1-2 ​ b. Commercial Automobile Liability: ​ ​ Bodily Injury and Property ​ Damage ​ $1,000,000 per accident ​ ​ c. Employer’s Liability: ​ ​ Each Accident $500,000 ​ Disease – Policy Limit $500,000 ​ Disease – Each Employee $500,000 ​ ​ d. Umbrella Liability: ​ ​ Bodily Injury and Property ​ Damage ​ Commercially reasonable amounts ​ (excess of coverages a, b and c above), ​ but in any event no less than $5,000,000 ​ per occurrence / aggregate. ​ ​ All subcontractors for Tenant contractors shall carry the same coverages and limits as specified ​ above, unless different limits are reasonably approved by Landlord. The foregoing policies shall ​ contain a provision that coverages afforded under the policies shall not be canceled or not ​ renewed until at least thirty (30) days’ prior written notice has been given to the Landlord. ​ Certificates of insurance including required endorsements showing such coverages to be in force ​ shall be filed with Landlord prior to the commencement of any Tenant Work and prior to each ​ renewal. Coverage for completed operations must be maintained for the lesser of ten (10) years ​ and the applicable statue of repose following completion of the Tenant Work, and certificates ​ evidencing this coverage must be provided to Landlord. The minimum A.M. Best’s rating of ​ each insurer shall be A- VII. Landlord and its mortgagees shall be named as an additional ​ insureds under Tenant contractors’ Commercial General Liability, CommercialAutomobile ​ Liability and Umbrella Liability Insurance policies as respects liability arising from work or ​ operations performed, or ownership, maintenance or use of autos, by or on behalf of such ​ contractors. Each contractor and its insurers shall provide waivers of subrogation with respect to ​ any claims covered or that should have been covered by valid and collectible insurance, ​ including any deductibles or self-insurance maintained thereunder. ​ ​ If any contractor’s work involves the handling or removal of asbestos (as determined by ​ Landlord in its sole and absolute discretion), such contractor shall also carry Pollution Legal ​ Liability insurance. Such coverage shall include bodily injury, sickness, disease, death or mental ​ anguish or shock sustained by any person; property damage, including physical injury to or ​ destruction of tangible property (including the resulting loss of use thereof), clean-up costs and ​ the loss of use of tangible property that has not been physically injured or destroyed; and defense ​ costs, charges and expenses incurred in the investigation, adjustment or defense of claims for ​ such damages. Coverage shall apply to both sudden and non-sudden pollution conditions ​ including the discharge, dispersal, release or escape of smoke, vapors, soot, fumes, acids, alkalis, ​ toxic chemicals, liquids or gases, waste materials or other irritants, contaminants or pollutants ​ into or upon land, the atmosphere or anywatercourse or body of water. Claims-made coverage ​ is permitted, provided the policy retroactive date is continuously maintained prior to the Term ​ Commencement Date, and coverage is continuously maintained during all periods in which ​ ​ B-1-3 ​ Tenant occupies the Premises. Coverage shall be maintained with limits of not less than ​ $1,000,000 per incident with a $2,000,000 policy aggregate. ​ ​ C-1 ​ EXHIBIT C ​ ​ ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE ​ AND TERM EXPIRATION DATE ​ ​ THIS ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE AND TERM ​ EXPIRATION DATE is entered into as of [ ], 20[ ], with reference to that certain ​ Lease (the “Lease”) dated as of [ ], 201_, by LA JOLLA PHARMACEUTICAL ​ COMPANY, a California corporation (“Tenant”), in favor of BMR-AXIOM LP, a Delaware ​ limited partnership (“Landlord”). All capitalized terms used herein without definition shall have ​ the meanings ascribed to them in the Lease. ​ ​ Tenant hereby confirms the following: ​ ​ 1. Tenant accepted possession of the Premises for construction of improvements or the ​ installation of personal or other property on [ ], 20[ ], and for use in accordance with ​ the Permitted Use on [ ], 20[ ]. Tenant first occupied the Premises for the Permitted ​ Use on [ ], 20[ ]. ​ ​ 2. The Premises are in good order, condition and repair. ​ ​ 3. The Tenant Improvements are Substantially Complete. ​ ​ 4. All conditions of the Lease to be performed by Landlord as a condition to the full ​ effectiveness of the Lease have been satisfied, and Landlord has fulfilled all of its duties in the ​ nature of inducements offered to Tenant to lease the Premises. ​ ​ 5. In accordance with the provisions of Article 4 of the Lease, the Term Commencement ​ Date is [ ], 20[ ], and, unless the Lease is terminated prior to the Term Expiration Date ​ pursuant to its terms, the Term Expiration Date shall be [ ], 20[ ]. ​ ​ 6. The Lease is in full force and effect, and thesame represents the entire agreement ​ between Landlord and Tenant concerning the Premises[, except [ ]]. ​ ​ 7. Tenant has no existing defenses against the enforcement of the Lease by Landlord, and ​ there exist no offsets or credits against Rent owed or to be owed by Tenant. ​ ​ 8. The obligation to pay Rent is presently in effect and all Rent obligations on the part of ​ Tenant under the Lease commenced to accrue on [ ], 20[ ], with Base Rent payable on ​ the dates and amounts set forth in the chart below: ​ ​ ​ ​ Dates ​ Approximate ​ Square Feet of ​ Rentable Area ​ ​ Base Rent per Square ​ Foot of Rentable Area ​ ​ Monthly ​ Base Rent ​ ​ Annual ​ Base Rent ​ [ ]/[ ]/[ ]- ​ [ ]/[ ]/[ ] ​ [ ] $[ ] ​ [monthly][OR][annually] ​ [ ] [ ] ​ ​ C-2 ​ 9. The undersigned Tenant has not made any prior assignment, transfer, hypothecation or ​ pledge of the Lease or of the rents thereunder or sublease of the Premises or any portion thereof. ​ ​ [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] ​ ​ C-3 ​ IN WITNESS WHEREOF, Tenant has executed this Acknowledgment of Term ​ Commencement Date and Term Expiration Date as of the date first written above. ​ ​ TENANT: ​ ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ ​ By: ​ Name: ​ Title: ​ ​ D-1 ​ EXHIBIT D ​ LANDLORD WORK ​ Pre-Delivery Landlord Work ​ ​ ● One (1) set of restrooms on each floor of the Building; and ​ ● Work to the Base Building mechanical systems (detailed description below); and ​ ● Electrical work (detailed description below); and ​ ● Egress lighting sufficient for Building core and shell; and ​ ● Refinish the elevator cabs in the Building; and ​ ● Notifier fire alarm system expandable for Tenant Improvements ​ Description of Base Building Mechanical Work ​ Laboratory ​ ● (1) new air-cooled chiller (Capacity = 180 Tons) and chilled water pumps. ​ ● (2) new hot water boilers and pumps. (Capacity=1,999 MBH each) ​ ● Building management system serving centralized HVAC equipment and core building ​ spaces only. Airflow controls and temperature controls within Premises are excluded. ​ ● New galvanized supply air and exhaust air duct risers. ​ ● Centralized laboratory air compressor (40 HP) and vacuum pumps (three at 10 HP each) ​ with main piping risers stubbed to each floor. ​ ​ Office ​ ● (1) new rooftop VAV package unit, shared between floors (Capacity: 16,000 cfm) ​ ● Building management system serving centralized HVAC equipment and core building ​ spaces only. Airflow controls and temperature controls within Premises are excluded. ​ ● (7) new stand-alone split system fan coils for core support rooms ​ ● New galvanized supply air and exhaust air duct risers. ​ ​ Electrical Work ​ ​ ● New 800 Amp main breakers and SDG&E meters to serveeach floor. All electrical ​ distribution downstream of SDG&E meters and automatic transfer switch gear serving ​ Premises is excluded. ​ ​ Post-Delivery Landlord Work ​ ​ ● Paint the Exterior walls of the Building ​ ● Site improvements including landscaping, hardscaping, new slurry coat and striping of ​ the parking lot, patio on the northwest side of the Building; and ​ ● Amenities Center ​ ​ ​ EXHIBIT E ​ ​ FORM OF LETTER OF CREDIT ​ ​ IRREVOCABLE STANDBY LETTER OF CREDIT NUMBER XXX ​ DATE: , 20 ​ BENEFICIARY: ​ BMR-AXIOM LP ​ 17190 BERNARDO CENTER DRIVE ​ SAN DIEGO, CALIFORNIA 92128 ​ ATTN: FINANCE DEPARTMENT ​ ​ APPLICANT: ​ [INSERT NAME AND ADDRESS] ​ ​ AMOUNT OF LETTER OF CREDIT: ​ USD XXX ​ (XXX AND 00/100 UNITED STATES DOLLARS) ​ ​ DATE AND PLACE OF EXPIRATION: ​ [INSERT EXPIRATION DATE] ​ AT THE COUNTERS OF JPMORGAN CHASE BANK, N.A. ​ CHICAGO, ILLINOIS, USA ​ ​ ​ LADIES AND GENTLEMEN: ​ ​ WE, JPMORGAN CHASE BANK, N.A., LOCATED AT: 131 SOUTH DEARBORN, ​ 5TH FLOOR, MAIL CODE: IL1-0236, CHICAGO, ILLINOIS, 60603-5506 (THE “ISSUING ​ BANK”), ESTABLISH IN FAVOR OF BMR-AXIOM LP, LOCATED AT: 17190 ​ BERNARDO CENTER DRIVE, SAN DIEGO, CALIFORNIA, 92128, ATTN: FINANCE ​ DEPARTMENT (THE “BENEFICIARY”) OUR IRREVOCABLE AND ​ UNCONDITIONAL (SUBJECT TO THE CONDITIONS HEREIN) STANDBY LETTER ​ OF CREDIT NUMBER XXX (THE “L/C”) FOR AN AGGREGATE AMOUNT OF USD ​ XXX (XXX AND 00/100 UNITED STATES DOLLARS), EXPIRING AT 5.00 P.M. ​ (CHICAGO TIME) ON [INSERT EXPIRATION DATE] OR, IF SUCH DAY IS NOT A ​ BUSINESS DAY, THEN THE NEXT SUCCEEDING BUSINESS DAY (SUCH DATE, AS ​ EXTENDED FROM TIME TO TIME, THE “EXPIRATION DATE”). AS USED ​ HEREIN, THE TERM“BUSINESS DAY” MEANS ANY DAY OTHER THAN A ​ SATURDAY, SUNDAY, OR A DAY ON WHICH BANKS IN THE STATE OF ILLINOIS ​ ARE AUTHORIZED OR REQUIRED TO BE CLOSED, AND A DAY ON WHICH ​ PAYMENTS CAN BE EFFECTED ON THE FEDWIRE SYSTEM. ​ ​ ​ ​ ​ LA JOLLA PHARMACEUTICAL-PREVET-JLM-2016 11-1688-CLEAN COPY ​ ​ E-2 ​ WE AUTHORIZE THE BENEFICIARY TO DRAW ON US FOR THE ACCOUNT OF ​ [INSERT APPLICANT NAME], LOCATED AT: [INSERT APPLICANT ADDRESS] (THE ​ “ACCOUNT PARTY”), UNDER THE TERMS AND CONDITIONS OF THIS L/C. ​ ​ FUNDS UNDER THIS L/C ARE AVAILABLE BY PRESENTING THE FOLLOWING ​ DOCUMENTATION (THE “DRAWING DOCUMENTATION”): (A) THE ORIGINAL L/C; ​ AND (B) A SIGHT DRAFT COMPLETED IN THE FORM OF ATTACHMENT 1 TO THIS ​ L/C, WITH BLANKS FILLED IN AND BRACKETED ITEMS PROVIDED AS ​ APPROPRIATE. NO OTHER EVIDENCE OF AUTHORITY, CERTIFICATE, OR ​ DOCUMENTATION IS REQUIRED. ​ ​ DRAWING DOCUMENTATION MUST BE PRESENTED AT THE ISSUING ​ BANK’S OFFICE AT: 131 SOUTH DEARBORN, 5TH FLOOR, MAIL CODE: IL1-0236, ​ CHICAGO, ILLINOIS, 60603-5506, ATTENTION: STANDBY LETTER OF CREDIT UNIT ​ ON OR BEFORE THE EXPIRATION DATE BY CERTIFIED MAIL, PERSONAL ​ PRESENTATION, COURIER OR MESSENGER SERVICE. ​ ​ NOTWITHSTANDING ANYTHING HEREIN TO THE CONTRARY, DRAWINGS ​ PRESENTED BY TELECOPY ("FAX") TO FAX NUMBER 312-233- , OR ​ ALTERNATELY TO FAX NUMBER 312-233- ARE ACCEPTABLE, UNDER ​ TELEPHONE PRE-ADVICE TO 312-385- , OR ALTERNATELY TO 1-800-634-1969, ​ PROVIDED THAT SUCH FAX PRESENTATION IS RECEIVED ON OR BEFORE THE ​EXPIRATION DATE ON THIS L/C IN ACCORDANCE WITH THE TERMS AND ​ CONDITIONS OF THIS L/C, IT BEING UNDERSTOOD THAT ANY SUCH FAX ​ PRESENTATION SHALL BE CONSIDERED THE SOLE OPERATIVE INSTRUMENT OF ​ DRAWING. IN THE EVENT OF PRESENTATION BY FAX, THE ORIGINAL ​ DOCUMENTS SHOULD NOT ALSO BE PRESENTED. ​ ​ WE ENGAGE WITH YOU THAT DOCUMENTS PRESENTED UNDER AND IN ​ COMPLIANCE WITH THE TERMS AND CONDITIONS OF THIS L/C WILL BE DULY ​ HONORED ON PRESENTATION IF PRESENTED AT THE OFFICES OF THE ISSUING ​ BANK LOCATED AT: 131 SOUTH DEARBORN, 5TH FLOOR, MAIL CODE IL1-0236, ​ CHICAGO, ILLINOIS 60603-5506, ATTENTION: STANDBY LETTER OF CREDIT UNIT, ​ ON OR BEFORE THE EXPIRATION DATE OF THIS L/C. ALL PAYMENTS DUE ​ HEREUNDER SHALL BE MADE BY WIRE TRANSFER TO THE BENEFICIARY’S ​ ACCOUNT PER THEIR INSTRUCTIONS. ALL DOCUMENTS PRESENTED MUST BE IN ​ ENGLISH. ​ ​ IF BENEFICIARY PRESENTS PROPER DRAWING DOCUMENTATION TO US ON ​ OR BEFORE THE EXPIRATION DATE, THEN WE SHALL PAY UNDER THIS L/C AT OR ​ BEFORE THE FOLLOWING TIME (THE “PAYMENT DEADLINE”): (A) IF ​ PRESENTMENT IS MADE AT OR BEFORE 12.00 NOON (CHICAGO TIME) ON ANY ​ BUSINESS DAY, THEN PAYMENT SHALL BE MADE ON THE 3RD (THIRD) BUSINESS ​DAY; AND (B) IF PRESENTMENT IS MADE AFTER 12.00 NOON (CHICAGO TIME) ON ​ ANY BUSINESS DAY, THEN PAYMENT SHALL BE MADE ON THE 4TH (FOURTH) ​ BUSINESS DAY. IF WE DETERMINE THAT DRAWING DOCUMENTATION DOES NOT ​ CONFIRM TO THE TERMS AND CONDITIONS OF THE L/C, WE SHALL SEND THE ​ ​ E-3 ​ BENEFICIARY NOTICE IN WRITING, THAT THE DEMAND FOR PAYMENT WAS NOT ​ EFFECTED IN ACCORDANCE WITH THE TERMS OF THE L/C, STATING THE ​ REASONS THEREFOR AND THAT WE SHALL RETURN THE DRAWING ​ DOCUMENTATION TO THE BENEFICIARY. UPON BEING NOTIFIED THAT THE ​ DEMAND FOR PAYMENT WAS NOT EFFECTED IN CONFORMITY WITH THIS L/C, ​ THE BENEFICIARY MAY ATTEMPT TO CORRECT ANY SUCH NON-CONFORMING ​ DEMAND FOR PAYMENT TO THE EXTENT THAT THE BENEFICIARY IS ENTITLED ​ TO DO SO AND WITHIN THE THEN CURRENT EXPIRATION DATE OF THIS L/C. ​ ​ PARTIAL DRAWINGS ARE PERMITTED. EXCEPT WHEN THE AMOUNT OF THE ​ DRAWING FULLY UTILIZES THIS LETTER OF CREDIT, WE UNDERTAKE TO RETURN ​ THE ORIGINAL L/C TO YOU WITH THE AMOUNT OF THE PAYMENT ENDORSED ​ THEREON. ​ ​ IT IS A CONDITION OF THIS L/C THAT THE EXPIRATION DATE SHALL BE ​ AUTOMATICALLY EXTENDED WITHOUT AMENDMENT FOR 1 (ONE) YEAR FROM ​ THE EXPIRATION DATE HEREOF OR ANY FUTURE EXPIRATION DATE UNLESS AT ​ LEAST 90 (NINETY) DAYS PRIOR TO SUCH EXPIRATION DATE WE SEND NOTICE ​ TO YOU BY CERTIFIED MAIL OR HAND DELIVERED COURIER, AT THE ADDRESS ​ STATED ABOVE, THAT WE ELECT NOT TO EXTEND THIS L/C FOR ANY SUCH ​ ADDITIONAL PERIOD. HOWEVER INNO EVENT SHALL THIS L/C BE ​ AUTOMATICALLY EXTENDED BEYOND [INSERT FINAL EXPIRATION DATE] (THE ​ “FINAL EXPIRATION DATE”). ​ ​ THIS L/C IS TRANSFERABLE, BUT ONLY IN ITS ENTIRETY, AND MAY BE ​ SUCCESSIVELY TRANSFERRED. TRANSFER OF THIS L/C SHALL BE EFFECTED BY ​ US UPON YOUR SUBMISSION OF THIS ORIGINAL LETTER OF CREDIT, INCLUDING ​ ALL AMENDMENTS, IF ANY, ACCOMPANIED BY OUR TRANSFER REQUEST FORM ​ DULY COMPLETED AND SIGNED, WITH THE SIGNATURE THEREON ​ AUTHENTICATED BY YOUR BANK. CHARGES AND FEES RELATED TO THE ​ TRANSFER OF THIS L/C WILL BE FOR THE ACCOUNT OF THE APPLICANT. IF YOU ​ WISH TO TRANSFER THE L/C, PLEASE CONTACT US FOR THE FORM WHICH WE ​ SHALL PROVIDE TO YOU UPON YOUR REQUEST. IN ANY EVENT, THIS L/C MAY ​ NOT BE TRANSFERRED TO ANY PERSON OR ENTITY LISTED IN OR OTHERWISE ​ SUBJECT TO, ANY SANCTION OR EMBARGO UNDER ANY APPLICABLE ​ RESTRICTIONS. ​ ​ ALL AMENDMENTS UNDER THIS LETTER OF CREDIT ARE SUBJECT TO THE ​ BENEFICIARY'S AGREEMENT. ​ ​ THIS L/C IS GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH ​ THE LAWS OF THE STATE OF NEW YORK, AND, EXCEPT AS OTHERWISE ​ EXPRESSLY STATED HEREIN, TO THE INTERNATIONAL STANDBY PRACTICES, ​ ICC PUBLICATION NO. 590 (THE“ISP98”), AND IN THE EVENT OF ANY ​ CONFLICT, THE LAWS OF THE STATE OF NEW YORK WILL CONTROL, ​ WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAWS. ​ ​ E-4 ​ PLEASE ADDRESS ALL CORRESPONDENCE REGARDING THIS L/C TO THE ​ ATTENTION OF: JPMORGAN CHASE BANK, N.A, 131 SOUTH DEARBORN, 5TH ​ FLOOR, MAIL CODE IL1-0236, CHICAGO, ILLINOIS 60603-5506, ATTENTION: ​ STANDBY LETTER OF CREDIT UNIT, INCLUDING THE L/C NUMBER MENTIONED ​ ABOVE. FOR TELEPHONE ASSISTANCE, PLEASE CONTACT THE STANDBY CLIENT ​ SERVICE UNIT AT 1-800-634-1969, OR 1-813-432-1210, AND HAVE THIS L/C NUMBER ​ AVAILABLE. ​ ​ ​ VERY TRULY YOURS, ​ JPMORGAN CHASE BANK, N.A. ​ [ISSUER SIGNATURE] ​ ​ E-2-1 ​ ATTACHMENT 1 ​ ​ TO IRREVOCABLE STANDBY LETTER OF CREDIT NUMBER XXX ​ FORM OF SIGHT DRAFT ​ [BENEFICIARY LETTERHEAD] ​ ​ TO: ​ JPMORGAN CHASE BANK, N.A. ​ 131 SOUTH DEARBORN ​ 5TH FLOOR, MAIL CODE: IL1-0236 ​ CHICAGO, ILLINOIS, 60603-5506 ​ ATTENTION: STANDBY LETTER OF CREDIT UNIT ​ ​ ​ SIGHT DRAFT ​ ​ ​ AT SIGHT, PAY TO THE ORDER OF , THE SUM OF ​ UNITED STATES DOLLARS ($ ). DRAWN UNDER JPMORGAN CHASE ​ BANK, N.A. IRREVOCABLE STANDBY LETTER OF CREDIT NO. ​ DATED . ​ ​ [JPMORGAN CHASE BANK, N.A. IS HEREBY DIRECTED TO PAY THE PROCEEDS OF ​ THIS SIGHT DRAFT SOLELY TO THE FOLLOWING ACCOUNT: ​ .] ​ ​ [NAME AND SIGNATURE BLOCK, WITH AUTHORIZED SIGNATURE OF THE ​ BENEFICIARY (SIGNED AS SUCH)] ​ ​ ​ DATE: ​ ​ ​ EXHIBIT F ​ ​ RULES AND REGULATIONS ​ ​ NOTHING IN THESE RULES AND REGULATIONS (“RULES AND ​ REGULATIONS”) SHALL SUPPLANT ANY PROVISION OF THE LEASE. IN THE ​ EVENT OF A CONFLICT OR INCONSISTENCY BETWEEN THESE RULES AND ​ REGULATIONS AND THE LEASE, THE LEASE SHALL PREVAIL. ​ ​ 1. No Tenant Party shall encumber or obstruct the common entrances, lobbies, elevators, ​ sidewalks and stairways of the Project or use them for any purposes other than ingress or egress ​ to and from the Building(s) or the Project. ​ ​ 2. Except as specifically provided in the Lease, no sign, placard, picture, advertisement, ​ name or notice shall be installed or displayed on any part of the outside of the Building(s) ​ without Landlord’s prior written consent. Landlord shall have the right to remove, at Tenant’s ​ sole cost and expense and without notice, any sign installed or displayed in violation of this rule. ​ ​ 3. If Landlord objects in writing to any curtains, blinds, shades, screens, hanging plants or ​ other similar objects attached to or used in connection with any window or door of the Premises ​ or placed on any windowsill, and (a) such window, door or windowsill is visible from the ​ exterior of the Premises and (b) such curtain, blind, shade, screen, hanging plant or other object ​ is not included in plans approved by Landlord, then Tenant shall promptly remove such curtains, ​ blinds, shades, screens, hanging plants or other similar objects atits sole cost and expense. ​ ​ 4. Tenant shall not place a load upon any floor of the Premises that exceeds the load per ​ square foot that (a) such floor was designed to carry or (b) is allowed by Applicable Laws. ​ Fixtures and equipment that cause noises or vibrations that may be transmitted to the structure of ​ the Building(s) to such a degree as to be objectionable to other tenants shall be placed and ​ maintained by Tenant, at Tenant’s sole cost and expense, on vibration eliminators or other ​ devices sufficient to eliminate such noises and vibrations to levels reasonably acceptable to ​ Landlord and the affected tenants of the Project. ​ ​ 5. Tenant shall not install any radio, television or other antennae; cell or other ​ communications equipment; or other devices on the roof or exterior walls of the Premises except ​ in accordance with the Lease. Tenant shall not interfere with radio, television or other digital or ​ electronic communications at the Project or elsewhere. ​ ​ 6. Canvassing, peddling, soliciting and distributing handbills or any other written material ​ within, on or around the Project (other than within the Premises) are prohibited. Tenant shall ​ cooperate with Landlord to prevent such activities by any Tenant Party. ​ ​ 7. Tenant shall store all of its trash, garbage and Hazardous Materials in receptacles within ​ its Premises or in receptacles designated by Landlord outside of the Premises. Tenant shall not ​ place in any such receptacle any material that cannot be disposed of inthe ordinary and ​ customary manner of trash, garbage and Hazardous Materials disposal. Any Hazardous ​ Materials transported through Common Area shall be held in secondary containment devices. ​ ​ F-1 ​ ​ F-2 ​ Tenant shall be responsible, at its sole cost and expense, for Tenant’s removal of its trash, ​ garbage and Hazardous Materials. Tenant is encouraged to participate in the waste removal and ​ recycling program in place at the Project. ​ ​ 8. The Premises shall not be used for lodging or for any improper, immoral or objectionable ​ purpose. ​ ​ 9. Tenant shall not, without Landlord’s prior written consent, use the name of the Project, if ​ any, in connection with or in promoting or advertising Tenant’s business except as Tenant’s ​ address. ​ ​ 10. Tenant shall comply with all safety, fire protection and evacuation procedures and ​ regulations established by Landlord or any Governmental Authority. ​ ​ 11. Tenant assumes any and all responsibility for protecting the Premises from theft, robbery ​ and pilferage, which responsibility includes keeping doors locked and other means of entry to ​ the Premises closed. ​ ​ 12. Tenant shall not modify any locks to the Premises without Landlord’s prior written ​ consent, which consent Landlord shall not unreasonably withhold, condition or delay. Tenant ​ shall furnish Landlord with copies of keys, pass cards or similar devices for locks to the ​ Premises. ​ ​ 13. Tenant shall cooperate and participate in all reasonable security programs affecting the ​ Premises. ​ ​ 14. Tenant shall not permit any animals in the Project, other than for service animals or for ​ use in laboratory experiments. ​ ​ 15. The water and wash closets and other plumbing fixtures shallnot be used for any ​ purposes other than those for which they were constructed, and no sweepings, rubbish, rags or ​ other substances shall be deposited therein. ​ ​ 16. Discharge of industrial sewage shall only be permitted if Tenant, at its sole expense, first ​ obtains all necessary permits and licenses therefor from all applicable Governmental Authorities. ​ ​ 17. Smoking is prohibited inside the Building, except in designated outdoor areas of the ​ Project (if any). ​ ​ 18. The Project’s hours of operation are currently 24 hours a day seven days a week. ​ ​ 19. Tenant shall comply with all orders, requirements and conditions now or hereafter ​ imposed by Applicable Laws or Landlord (“Waste Regulations”) regarding the collection, ​ sorting, separation and recycling of waste products, garbage, refuse and trash generated by ​ Tenant (collectively, “Waste Products”), including (without limitation) the separation of Waste ​ Products into receptacles reasonably approved by Landlord and the removal of such receptacles ​ in accordance with any collection schedules prescribed by Waste Regulations. ​ ​ F-3 ​ 20. Tenant, at Tenant’s sole cost and expense, shall cause the Premises to be exterminated on ​ a monthly basis to Landlord’s reasonable satisfaction and shall cause all portions of the Premises ​ used for the storage, preparation, service or consumption of food or beverages to be cleaned ​ daily in a manner reasonably satisfactory to Landlord, and to be treated against infestation by ​ insects, rodents and other vermin and pests whenever there is evidence of any infestation. ​ Tenant shall not permit any person to enter the Premises or the Project for the purpose of ​ providing such extermination services, unless such persons have been approved by Landlord. If ​ requested by Landlord, Tenant shall, at Tenant’s sole cost and expense, store any refuse ​ generated in the Premises by the consumption of food or beverages in a cold box or similar ​ facility. ​ ​ 21. If Tenant desires to use any portion of the Common Area for a Tenant-related event, ​ Tenant must notify Landlord in writing at least thirty (30) days prior to such event on the form ​ attached as Attachment 1 to this Exhibit, which use shall be subject to Landlord’s prior written ​ consent, not to be unreasonably withheld, conditioned or delayed. Notwithstanding anything in ​ this Lease or the completed and executed Attachment to the contrary, Tenant shall be solely ​ responsible for setting up and taking down any equipment or other materials required for the ​ event, and shall promptly pickup any litter and report any property damage to Landlord related ​ to the event. Any use of the Common Area pursuant to this Section shall be subject to the ​ provisions of Article 28 of the Lease. ​ ​ Landlord may waive any one or more of these Rules and Regulations for the benefit of ​ Tenant or any other tenant, but no such waiver by Landlord shall be construed as a waiver of ​ such Rules and Regulations in favor of Tenant or any other tenant, nor prevent Landlord from ​ thereafter enforcing any such Rules and Regulations against any or all of the tenants of the ​ Project, including Tenant. These Rules and Regulations are in addition to, and shall not be ​ construed to in any way modify or amend, in whole or in part, the terms covenants, agreements ​ and conditions of the Lease. Landlord reserves the right to make such other and reasonable ​ additional rules and regulations as, in its judgment, may from time to time be needed for safety ​ and security, the care and cleanliness of the Project, or the preservation of good order therein; ​ provided, however, that Tenant shall not be obligated to adhere to such additional rules or ​ regulations until Landlord has provided Tenant with written notice thereof. Tenant agrees to ​ abide by these Rules and Regulations and any such additional rules and regulations issued or ​ adopted by Landlord. Tenant shall be responsible for the observance of these Rules and ​ Regulations by all Tenant Parties. ​ ​ F-1-1 ​ ATTACHMENT 1 TO EXHIBIT F ​ REQUEST FOR USE OF COMMON AREA ​ REQUEST FOR USE OF COMMON AREA ​ ​ Date of Request: ​ ​ Landlord/Owner: ​ ​ Tenant/Requestor: ​ ​ Property Location: ​ ​ Event Description: ​ ​ ​ ​ ​ ​ ​ ​ Proposed Plan for Security & Cleaning: ​ ​ ​ ​ ​ ​ ​ ​ Date of Event: ​ ​ Hours of Event: (to include set-up and take down): ​ ​ Location at Property (see attached map): ​ ​ Number of Attendees: ​ ​ Open to the Public? [ ] YES [ ] NO ​ ​ Food and/or Beverages? [ ] YES [ ] NO ​ If YES: ​ ​ ● Will food be prepared on site? ​ ​ ​ [ ] YES ​ ​ ​ [ ] NO ​ ​ ● Please describe: ​ ​ ● Will alcohol be served? [ ] YES [ ] NO ​ ​ ● Please describe: ​ ​ ● Will attendees be charged for alcohol? [ ] YES [ ] NO ​ ​ F-1-2 ​ ● Is alcohol license or permit required? [ ] YES [ ] NO ​ ​ ● Does caterer have alcohol license or permit: [ ] YES [ ] NO [ ] N/A ​ Other Amenities (tent, booths, band, food trucks, bounce house, etc.): ​ ​ ​ ​ ​ ​ ​ ​ ​ Other Event Details or Special Circumstances: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ The undersigned certifies that the foregoing is true, accurate and complete and he/she is duly ​ authorized to sign and submit this request on behalf of the Tenant/Requestor named above. ​ ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ By: ​ Name: ​ Title: ​ Date: ​ ​ G-1 ​ EXHIBIT G ​ ​ FORM OF ADDITIONAL TI ALLOWANCE ACCEPTANCE LETTER ​ ​ ​ [TENANT LETTERHEAD] ​ ​ ​ BMR–Axiom LP ​ 17190 Bernardo Center Drive ​ San Diego, California 92128 ​ Attn: Vice President, Real Estate Legal ​ ​ [Date] ​ ​ ​ Re: Additional TI Allowance ​ ​ To Whom It May Concern: ​ ​ This letter concerns that certain Lease dated as of [ ], 20[ ] (the "Lease"), between ​ BMR–Axiom LP, a Delaware limited partnership ("Landlord") and La Jolla Pharmaceutical ​ Company, a California corporation ("Tenant"). Capitalized terms not otherwise defined herein ​ shall have the meanings given them in the Lease. ​ ​ Tenant hereby notifies Landlord that it wishes to exercise its right to utilize the ​ Additional TI Allowance pursuant to Article 4 of the Lease. ​ ​ ​ [ ]. ​ If you have any questions, please do not hesitate to call [ ] at ([ ]) [ ]- ​ ​ Sincerely, ​ ​ ​ ​ [Name] ​ [Title of Authorized Signatory] ​ ​ ​ cc: ​ Karen Sztraicher ​ John Bonanno ​ Kevin Simonsen ​ ​ H-1 ​ EXHIBIT H ​ TENANT’S PROPERTY ​ ​ N-1 ​ EXHIBIT I ​ ​ FORM OF ESTOPPEL CERTIFICATE ​ ​ To: BMR-Axiom LP ​ 17190 Bernardo Center Drive ​ San Diego, California 92128 ​ Attention: Legal Department ​ ​ BioMed Realty, L.P. ​ 17190 Bernardo Center Drive ​ San Diego, California 92128 ​ ​ Re: 4550 Towne Centre Court (the “Premises”) at Towne Centre Court in San Diego, ​ California (the “Property”) ​ ​ The undersigned tenant (“Tenant”) hereby certifies to you as follows: ​ ​ 1. Tenant is a tenant at the Property under a lease (the “Lease”) for the Premises dated as of ​ [ ], 20[ ]. The Lease has not been cancelled, modified, assigned, extended or amended ​ [except as follows: [ ]], and there are no other agreements, written or oral, affecting or ​ relating to Tenant’s lease of the Premises or any other space at the Property. The lease term ​ expires on [ ], 20[ ]. ​ ​ 2. Tenant took possession of the Premises, currently consisting of [ ] square feet of ​ Rentable Area, on [ ], 20[ ], and commenced to pay rent on [ ], 20[ ]. Tenant ​ has full possession of the Premises, has not assigned the Lease or sublet any part of the Premises, ​ and does not hold the Premises under an assignment or sublease[, except as follows: [ ]]. ​ ​ 3. All base rent, rent escalations and additional rent under the Lease have been paid through ​ [ ], 20[ ]. There is no prepaid rent[, except $[ ]][, and the amount of security ​ deposit is $[ ] [in cash][OR][in the form of a letter of credit]]. Tenant currently has no ​ right to any future rent abatement under the Lease. ​ ​ 4. Base rent is currently payable in the amount of $[ ] per month. ​ ​ 5.Tenant is currently paying estimated payments of additional rent of $[ ] per ​ month on account of real estate taxes, insurance, management fees and Common Area ​ maintenance expenses. ​ ​ 6. All work to be performed for Tenant under the Lease has been performed as required ​ under the Lease and has been accepted by Tenant[, except [ ]], and all allowances to be ​ paid to Tenant, including allowances for tenant improvements, moving expenses or other items, ​ have been paid. ​ ​ 7. The Lease is in full force and effect, free from Default, and Tenant has no claims against ​ the landlord or offsets or defenses against rent, and there are no disputes with the landlord. ​ ​ F-2 ​ Tenant has received no notice of prior sale, transfer, assignment, hypothecation or pledge of the ​ Lease or of the rents payable thereunder[, except [ ]]. ​ ​ 8. [Tenant has the following expansion rights or options for leasing additional space at the ​ Property: [ ].][OR][Tenant has no rights or options to purchase the Property.] ​ ​ 9. To Tenant’s knowledge, no hazardous wastes have been generated, treated, stored or ​ disposed of by or on behalf of Tenant in, on or around the Premises or the Project in violation of ​ any environmental laws. ​ ​ 10. The undersigned has executed this Estoppel Certificate with the knowledge and ​ understanding that [INSERT NAME OF LANDLORD, PURCHASER OR LENDER, AS ​ APPROPRIATE] or its assignee is [acquiring the Property/making a loan secured by the ​ Property] in reliance on this certificate and that the undersigned shall be bound by this ​ certificate. The statements contained herein may be relied upon by [INSERT NAME OF ​ PURCHASER OR LENDER, AS APPROPRIATE], [LANDLORD], BioMed Realty, L.P., BRE ​ Edison Parent L.P., and any [other] mortgagee of the Property and their respective successors ​ and assigns. ​ ​ Any capitalized terms not defined herein shall have the respective meanings given in the Lease. ​ Dated this [ ] day of [ ], 20[ ]. ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ By: ​ Name: ​ Title: ​ ​ J-1- ​ EXHIBIT J ​ ​ INTENTIONALLY OMITTED ​ ​ K-1- ​ EXHIBIT K ​ ​ ROOFTOP LICENSE ​ Landlord hereby grants to Tenant a license (“Rooftop License”), which Rooftop License ​ shall be at no additional cost of expense to Tenant, to use portions of the rooftop of the Building ​ identified by Landlord from time to time as “Rooftop Installation Area” (the “Rooftop ​ Installation Area”) solely to operate, maintain, repair and replace rooftop antennae, mechanical ​ equipment, communications antennas and other equipment installed by Tenant in the Rooftop ​ Installation Area in accordance with this Article (“Tenant’s Rooftop Equipment”). Tenant’s ​ Rooftop Equipment shall be only for Tenant’s use of the Premises for the Permitted Use. ​ Notwithstanding anything to the contrary, Tenant’s rights under this Exhibit K shall be subject ​ and subordinate to the rights granted to Global in the Rooftop Lease. All capitalized terms used ​ herein and not otherwise defined shall have the meanings ascribed to them in the Lease to which ​ this Exhibit K is attached. ​ ​ Tenant shall install Tenant’s Rooftop Equipment at its sole cost and expense, at such ​ times and in such manner as Landlord may reasonably designate, and in accordance with this ​ Exhibit and the applicable provisions of the Lease regarding Alterations. Tenant’s Rooftop ​ Equipment and the installation thereof shall be subject to Landlord’s prior written approval, ​ which approval shall not be unreasonably withheld. Among other reasons, Landlord may ​ withhold approval if theinstallation or operation of Tenant’s Rooftop Equipment could ​ reasonably be expected to damage the structural integrity of the Building or to transmit ​ vibrations or noise or cause other adverse effects beyond the Premises to an extent not customary ​ in first class laboratory buildings, unless Tenant implements measures that are acceptable to ​ Landlord in its reasonable discretion to avoid any such damage or transmission. ​ ​ Tenant shall comply with any roof or roof-related warranties. Tenant shall obtain a letter ​ from Landlord’s roofing contractor within thirty (30) days after completion of any Tenant work ​ on the rooftop stating that such work did not affect any such warranties. Tenant, at its sole cost ​ and expense, shall inspect the Rooftop Installation Area at least annually, and correct any loose ​ bolts, fittings or other appurtenances and repair any damage to the roof caused by the installation ​ or operation of Tenant’s Rooftop Equipment. Tenant shall not permit the installation, ​ maintenance or operation of Tenant’s Rooftop Equipment to violate any Applicable Laws or ​ constitute a nuisance. Tenant shall pay Landlord within thirty (30) days after demand (a) all ​ applicable taxes, charges, fees or impositions imposed on Landlord by governmental authorities ​ as the result of Tenant’s use of the Rooftop Installation Areas in excess of those for which ​ Landlord would otherwise be responsible for the use or installation of Tenant’s Rooftop ​ Equipment and (b) theamount of any increase in Landlord’s insurance premiums as a result of ​ the installation of Tenant’s Rooftop Equipment. Upon Tenant’s written request to Landlord, ​ Landlord shall use commercially reasonable efforts to cause other tenants to remedy any ​ interference in the operation of Tenant’s Rooftop Equipment caused by any such tenants’ ​ equipment installed after the applicable piece of Tenant’s Rooftop Equipment; provided, ​ ​ K-2- ​ however, that Landlord shall not be required to request that such tenants waive their rights under ​ their respective leases. ​ ​ If Tenant’s Equipment (a) causes physical damage to the structural integrity of the ​ Building, (b) interferes with any telecommunications, mechanical or other systems located at or ​ near or servicing the Building or the Project that were installed prior to the installation of ​ Tenant’s Rooftop Equipment, (c) interferes with any other service provided to other tenants in ​ the Building or the Project by rooftop or penthouse installations that were installed prior to the ​ installation of Tenant’s Rooftop Equipment or (d) interferes with any other tenants’ business, in ​ each case in excess of that permissible under Federal Communications Commission regulations, ​ then Tenant shall cooperate with Landlord to determine the source of the damage or interference ​ and promptly repair such damage and eliminate such interference, in each case at Tenant’s sole ​ cost and expense, within ten (10) business days after receipt of notice (which notice may be oral; ​ provided that Landlord also delivers to Tenant written notice of such damage or interference ​ within twenty-four (24) hours after providing oral notice) of such damage or interference, or ​ within a reasonable time if such cannot be accomplished within ten (10) business days so long as ​ Tenant diligently and continuously prosecutes such cure to completion. ​ ​ Landlord reserves the right to cause Tenant to relocateTenant’s Rooftop Equipment to ​ comparably functional space on the roof or in the penthouse of the Building by giving Tenant ​ prior written notice thereof. Landlord agrees to pay the reasonable costs thereof. Tenant shall ​ arrange for the relocation of Tenant’s Rooftop Equipment within sixty (60) days after receipt of ​ Landlord’s notification of such relocation. In the event Tenant fails to arrange for relocation ​ within such sixty (60)-day period, Landlord shall have the right to arrange for the relocation of ​ Tenant’s Rooftop Equipment in a manner that does not unnecessarily interrupt or interfere with ​ Tenant’s use of the Premises for the Permitted Use. ​ ​ Notwithstanding anything to the contrary in this Exhibit, Tenant shall, prior to ​ commencing any work on the rooftop of the Building, give Landlord at least thirty days (30) ​ days’ prior written notice. ​ ​ K-1- ​ EXHIBIT L ​ ​ TI ALLOWANCE AND COMMISSION FEE SCHEDULE ​ ​ Subsection 3.2.2(z)(i) (TI Allowance): $13,696,320. ​ ​ ● Base TI Allowance: $12,451,200. ​ ​ ● Additional TI Allowance: $1,245,120. ​ ​ Subsection 3.2.2(z)(ii) (Commission Fee): $1,786,760.58. ​ ​ ​ EXHIBIT M ​ ​ FORM SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT ​ ​ ​ ​ RECORDING REQUESTED BY ​ AND WHEN RECORDED MAIL TO: ​ ​ Eric F. Allendorf, Esq. ​ Paul Hastings LLP ​ 200 Park Avenue ​ New York, New York 10166 ​ ​ ​ ​ ​ ​ ​ ​ ​ (Space Above For Recorder’s Use) ​ ​ ​ SUBORDINATION AGREEMENT, ACKNOWLEDGMENT OF LEASE ASSIGNMENT, ATTORNMENT ​ AND NON-DISTURBANCE AGREEMENT ​ (Lease to Security Instrument) ​ ​ NOTICE: THIS SUBORDINATION AGREEMENT RESULTS IN YOUR SECURITY INTEREST IN ​ THE PROPERTY BECOMING SUBJECT TO AND OF LOWER PRIORITY THAN THE ​ LIEN OF SOME OTHER OR LATER SECURITY INSTRUMENT. ​ ​ THIS SUBORDINATION AGREEMENT, ACKNOWLEDGMENT OF LEASE ASSIGNMENT, ATTORNMENT ​ AND NON-DISTURBANCE AGREEMENT (“Agreement”) is made this day of , 2016 by and among ​ BMR-Axiom LP, a Delaware limited partnership, owner of the real property hereinafter described (“Mortgagor”), ​ La Jolla Pharmaceutical Company, a California corporation (“Tenant”), AB Commercial Real Estate Debt – B2 ​ S.Á.R.L., a Luxembourg private company with limited liability, as administrative agent for certain lenders party to ​ the Loan Agreement (defined below), and their respective successors and assigns (“Lender”). ​ R E C I T A L S ​ ​ 1. Pursuant to the terms and provisions of the unrecorded lease dated December , 2016 (“Lease”), Tenant ​ holds aleasehold estate in and to a portion of the property described in the Lease (which property, together ​ with all improvements now or hereafter located on the property, is defined as the “Property”, as more ​ particularly described on Exhibit A attached hereto). ​ ​ 2. Mortgagor has executed that certain Loan Agreement, dated as of the date hereof, by and among ​ Mortgagor, Lender and certain other parties thereto (as the same may be amended, restated and/or replaced ​ from time to time, the “Loan Agreement”) and that certain Security Instrument (as defined in the Loan ​ Agreement) encumbering the Property and otherwise securing, among other things, those certain Notes (as ​ defined in the Loan Agreement) in favor of the Lender (“Loan”). The Security Instrument is being ​ recorded in the real property records where the Property is located. ​ ​ 3. As a condition to Lender making the Loan secured by the Security Instrument, Lender requires that the ​ Security Instrument be unconditionally and at all times remain a lien on the Property, prior and superior to ​ ​ ​ all the rights of Tenant under the Lease and that the Tenant specifically and unconditionally subordinate ​ the Lease to the lien of the Security Instrument. ​ ​ 4. Mortgagor and Tenant have agreed to the subordination, attornment and other agreements herein in favor ​ of Lender. ​ ​ NOW THEREFORE, for valuable consideration and to induce Lender to make the Loan, Mortgagor and Tenant ​ hereby agree for the benefit of Lender as follows: ​ 1. SUBORDINATION. Mortgagor and Tenant hereby agree that: ​ ​ a) Prior Lien. The Security Instrument securing the Note in favor of Lender and any modifications, ​ renewals or extensions thereof (including, without limitation, any modifications, renewals or ​ extensions with respect to any additional advances made subject to the Security Instrument), shall ​ unconditionally be and at all times remain a lien on the Property prior and superior to the Lease ​ (including, without limitation, any amendments, modifications, renewals or extensions thereof); ​ ​ b) Whole Agreement. This Agreement shall be the whole agreement and only agreement with ​ regard to the subordination of the Lease to the lien of the Security Instrument and shall supersede ​ and cancel, but only insofar as would affect the priority between the Security Instrument and the ​ Lease, any prior agreements as to such subordination, including, without limitation, those ​ provisions, if any, contained in the Lease which provide for the subordination of the Lease to a ​ deed or deeds oftrust or to a mortgage or mortgages. ​ ​ AND FURTHER, Tenant individually declares, agrees and acknowledges for the benefit of Lender that: ​ ​ c) Use of Proceeds. Lender, in making disbursements pursuant to the Note, the Security Instrument ​ or any loan agreements with respect to the Property, is under no obligation or duty to, nor has ​ Lender represented that it will, see to the application of such proceeds by the person or persons to ​ whom Lender disburses such proceeds, and any application or use of such proceeds for purposes ​ other than those provided for in such agreement or agreements shall not defeat this agreement to ​ subordinate in whole or in part; and ​ ​ d) Subordination. Tenant intentionally and unconditionally waives, relinquishes and subordinates ​ all of Tenant’s right, title and interest in and to the Property to the lien of the Security Instrument ​ and understands that in reliance upon, and in consideration of, this subordination, specific loans ​ and advances are being and will be made by Lender and, as part and parcel thereof, specific ​ monetary and other obligations are being and will be entered into which would not be made or ​ entered into but for said reliance upon this waiver, relinquishment and subordination. ​ ​ 2. ASSIGNMENT. Tenant acknowledges and consents to the assignment of the Lease by Mortgagor in ​ favor of Lender. ​ ​ 3. ADDITIONAL AGREEMENTS. Tenant covenants and agrees that, during all such times as theLoan is ​ outstanding: ​ ​ a) Notice of Default. Tenant will notify Lender in writing concurrently with any notice given to ​ Mortgagor of any default by Mortgagor under the Lease, and Tenant agrees that Lender has the ​ right (but not the obligation) to cure any breach or default specified in such notice within the time ​ periods set forth below and Tenant will not declare a default of the Lease, as to Lender, or ​ terminate the Lease if Lender cures such default within thirty (30) days from and after the ​ expiration of the time period provided in the Lease for the cure thereof by Mortgagor; provided, ​ however, that if such default cannot with diligence be cured by Lender within such thirty (30) day ​ period, the commencement of action by Lender within such thirty (30) day period to remedy the ​ same shall be deemed sufficient so long as Lender pursues such cure with diligence. Further, ​ ​ ​ Tenant shall not terminate the Lease on the basis of any default by Landlord which is incurable by ​ Lender (such as, for example, the bankruptcy of Landlord or breach of any representation by ​ Landlord), provided Lender is proceeding with due diligence to commence an action to appoint a ​ receiver or to obtain title to the Property by foreclosure, deed in lieu of foreclosure, or otherwise ​ (collectively, “Foreclosure”). Tenant hereby agrees that no action taken by Lender to enforce ​ any rights under the Security Instrument or related security documents, by reason of any default ​ thereunder (including, without limitation, the appointment of a receiver, any Foreclosure or any ​ demand for rent under any assignment of rents or leases) shall give rise to any right of Tenant to ​ terminate the Lease, nor shall such action invalidate or constitute a breach of any of the terms of ​ the Lease; ​ ​ b) No Advance Rents. Other than the payment of a security deposit as required under the Lease, ​ Tenant will make no payments or prepayments of rent more than one (1) month in advance of the ​ time when the same become due under the Lease; and ​ ​ c) Assignment of Rents. Upon receipt by Tenant of written notice directing the payment of rents by ​ Tenant to Lender, Tenant shall comply with such direction to pay such rents (including, without ​ limitation, any termination fees or other similar payments, including, without limitation, the ​ Clinical Trial Termination Fee (as defined in the Lease) and theAcquisition Termination Fee (as ​ defined in the Lease)) to Lender, and Mortgagor hereby acknowledges that Tenant shall be ​ entitled to rely upon any such direction received from Lender. ​ ​ d) Notice with Respect to Hazardous Materials. Tenant will deliver to Lender any notice or other ​ deliverable given to Mortgagor pursuant to the terms and provisions of Section 21.2 of the Lease ​ concurrently with the delivery of the same to Mortgagor. ​ ​ 4. ATTORNMENT. In the event of a foreclosure under the Security Instrument, Tenant agrees for the ​ benefit of Lender (including any transferee of Lender or any transferee of Mortgagor’s title in and to the ​ Property by Lender or the Lender’s exercise of the remedy of sale by foreclosure under the Security ​ Instrument (in each case, a “Successor Owner”) as follows: ​ ​ a) Payment of Rent. Tenant shall pay to Lender all rental payments required to be made by Tenant ​ pursuant to the terms of the Lease for the duration of the term of the Lease; ​ ​ b) Continuation of Performance. Tenant shall be bound to Lender in accordance with all of the ​ provisions of the Lease for the balance of the term thereof, and Tenant hereby attorns to Lender as ​ its landlord, such attornment to be effective and self-operative without the execution of any ​ further instrument immediately upon Lender succeeding to Mortgagor’s interest in the Lease and ​ giving written notice thereof to Tenant; and ​ ​ c) No Offset. Lender shall not be liable, nor subject to any offsets or defenseswhich Tenant may ​ have by reason of any act or omission of Mortgagor under the Lease, nor for the return of any ​ sums which Tenant may have paid to Mortgagor under the Lease as and for security deposits, ​ advance rentals or otherwise, except to the extent that such sums are actually delivered by ​ Mortgagor to Lender. ​ ​ d) Landlord Liability. Nothing in this Agreement shall impose upon Lender any liability for the ​ obligations of Landlord under the Lease unless and until Lender takes title to the Property; ​ provided, however, the foregoing shall not limit Successor Owner’s obligations under the Lease to ​ correct any conditions of a continuing nature that (i) existed as of the date of Successor Owner ​ shall become owner of the Property and (ii) violate Successor Owner’s obligations as landlord ​ under the Lease; provided that Successor Owner shall have received written notice of such ​ omissions, conditions or violations from Tenant and has had a reasonable opportunity to cure the ​ same. Anything herein or in the Lease to the contrary notwithstanding, in the event that a ​ Successor Owner shall acquire title to the Property or the portion thereof containing the Premises, ​ ​ ​ Successor Owner shall have no obligation, nor incur any liability, beyond Successor Owner’s then ​ interest, if any, in the Property, and Tenant shall look exclusively to such interest, if any, of ​ Successor Owner in the Property for the payment and discharge of any obligations imposed upon ​ Successor Owner hereunder or under the Lease, and Successor Owner is hereby released or ​ relieved of any other liability hereunder and under the Lease. Tenant agrees that, with respect to ​ any money judgment which may be obtained or secured by Tenant against Successor Owner, ​ Tenant shall look solely to the estate or interest owned by Successor Owner in the Property, and ​ Tenant will not collect or attempt to collect any such judgment out of any other assets of ​ Successor Owner. Except as specifically provided in this Agreement, Lender shall not, by virtue ​ of this Agreement, the Security Instrument or any other instrument to which Lender may be party, ​ be or become subject to any liability or obligation to Tenant under the Lease or otherwise. ​ ​ 5. NOTICE OF SECURITY INSTRUMENT. To the extent that the Lease shall entitle Tenant to notice of ​ the existence of any Security Instrument and the identity of any mortgagee or any ground lessor, this ​ Agreement shall constitute such notice to Tenant with respect to the Security Instrument and Lender. ​ ​ 6. NON-DISTURBANCE. In the event of a foreclosure under the Security Instrument, so long as thereshall ​ then exist no Default (as such term is defined in the Lease) on the part of Tenant under the Lease, Lender ​ agrees for itself and its successors and assigns that the leasehold interest of Tenant under the Lease shall ​ not be extinguished or terminated by reason of such foreclosure, but rather the Lease shall continue in full ​ force and effect and Lender shall recognize and accept Tenant as tenant under the Lease subject to the ​ terms and provisions of the Lease except as modified by this Agreement. ​ ​ 7. MISCELLANEOUS. ​ ​ a) NOTICES. All notices, demands, or other communications under this Agreement and the other ​ Loan Documents shall be in writing and shall be delivered to the appropriate party at the address ​ set forth below (subject to change from time to time by written notice to all other parties to this ​ Agreement). All notices, demands or other communications shall be considered as properly given ​ if delivered personally or sent by first class United States Postal Service mail, postage prepaid, or ​ by Overnight Express Mail or by overnight commercial courier service, charges prepaid, except ​ that notice of Default may be sent by certified mail, return receipt requested, charges prepaid. ​ Notices so sent shall be effective three (3) days after mailing, if mailed by first class mail, and ​ otherwise upon delivery or refusal; provided, however, that non-receipt of any communication as ​ the result of any change of address of which the sending party was notnotified or as the result of a ​ refusal to accept delivery shall be deemed receipt of such communication. For purposes of notice, ​ the address of the parties shall be: ​ ​ Mortgagor: BMR-Axiom LP c/o ​ BioMed Realty, L.P. ​ 17190 Bernardo Center Drive ​ San Diego, California 92128 ​ Attention: Real Estate Legal Department ​ With copies to: Simpson Thacher & Bartlett LLP ​ 425 Lexington Avenue ​ New York, New York 10017 ​ Attention: Krista Miniutti, Esq. ​ Tenant: La Jolla Pharmaceutical Company ​ 10182 Telesis Court, Suite 600 ​ San Diego, California 92121 ​ Attention: Legal Department ​ With copies to: Gibson, Dunn & Crutcher LLP ​ ​ 333 South Grand Avenue ​ Los Angeles, California 90071 ​ Attention: Mark S. Pecheck ​ Lender: AB Commercial Real Estate Debt – B2 S.Á.R.L., ​ c/o AllianceBernstein, L.P. ​ 1345 Avenue of the Americas ​ New York, New York 10105 ​ With copies to: Paul Hasting LLP ​ 200 Park Avenue ​ New York, New York 10166 ​ Attention: Eric F. Allendorf, Esq. ​ ​ ​ Any party shall have the right to change its address for notice hereunder to any other location within the continental ​ United States by the giving notice to the other parties in the manner set forth hereinabove. ​ b) REMEDIES CUMULATIVE. All rights of Lender herein to collect rents on behalf of ​ Mortgagor under the Lease are cumulative and shall be in addition to any and all other rights and ​ remedies provided by law and by other agreements between Lender and Mortgagor or others. ​ ​ c) HEIRS, SUCCESSORS AND ASSIGNS. Except as otherwise expressly provided under the ​ terms and conditions herein, the terms of this Agreement shall bind and inure to the benefit of the ​ heirs, executors, administrators, nominees, successors and assigns of the parties hereto. ​ ​ d) HEADINGS. All article, section or other headings appearing in this Agreement are for ​ convenience of reference only and shall be disregarded in construing this Agreement. ​ ​ e) COUNTERPARTS. To facilitate execution, this document may be executed in as many ​ counterparts as may be convenient or required. It shall not be necessary that the signature of,or ​ on behalf of, each party, or that the signature of all persons required to bind any party, appear on ​ each counterpart. All counterparts shall collectively constitute a single document. It shall not be ​ necessary in making proof of this document to produce or account for more than a single ​ counterpart containing the respective signatures of, or on behalf of, each of the parties hereto. ​ Any signature page to any counterpart may be detached from such counterpart without impairing ​ the legal effect of the signatures thereon and thereafter attached to another counterpart identical ​ thereto except having attached to it additional signature pages. ​ ​ f) EXHIBITS, SCHEDULES AND RIDERS. All exhibits, schedules, riders and other items ​ attached hereto are hereby incorporated into this Agreement for all purposes. ​ ​ g) WAIVER OF TRIAL BY JURY. EACH OF TENANT, LENDER AND LANDLORD ​ HEREBY IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY ​ ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR RELATING TO ​ THIS AGREEMENT. ​ ​ h) ENTIRE AGREEMENT. This Agreement contains the entire agreement between the parties ​ and no modifications shall be binding upon any party hereto unless set forth in a document duly ​ executed by or on behalf of such party. ​ ​ [No further text on this page] ​ ​ ​ IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first ​ above written. ​ ​ NOTICE: THIS SUBORDINATION AGREEMENT CONTAINS A PROVISION WHICH ALLOWS ​ THE PERSON OBLIGATED ON YOUR REAL PROPERTY SECURITY TO OBTAIN A ​ LOAN, A PORTION OF WHICH MAY BE EXPENDED FOR PURPOSES OTHER THAN ​ IMPROVEMENT OF THE LAND. ​ ​ IT IS RECOMMENDED THAT, PRIOR TO THE EXECUTION OF THIS AGREEMENT, ​ THE PARTIES CONSULT WITH THEIR ATTORNEYS WITH RESPECT HERETO. ​ ​ “TENANT” ​ LA JOLLA PHARMACEUTICAL COMPANY, ​ a California corporation ​ ​ ​ ​ ​ ​ ​ By: ​ Name: ​ Title: ​ ​ ​ [ACKNOWLEDGMENT ON THE FOLLOWING PAGE] ​ ​ ​ ​ ​ ACKNOWLEDGMENT ​ ​ [PROPER FORM OF ACKNOWLEDGMENT TO BE INSERTED] ​ ​ [SIGNATURES CONTINUE ON THE FOLLOWING PAGE] ​ ​ ​ ​ ​ “MORTGAGOR” ​ BMR-Axiom LP ​ a Delaware limited partnership ​ ​ ​ By: ​ Name: ​ Title: ​ ​ ​ [ACKNOWLEDGMENT ON THE FOLLOWING PAGE] ​ ​ ​ ​ ​ ACKNOWLEDGMENT ​ ​ [PROPER FORM OF ACKNOWLEDGMENT TO BE INSERTED] ​ ​ [SIGNATURES CONTINUE ON THE FOLLOWING PAGE] ​ ​ ​ ​ ​ “LENDER” ​ AB Commercial Real Estate Debt – B2 S.Á.R.L., ​ a Luxembourg private company with limited liability, as ​ administrative agent ​ ​ ​ ​ ​ By: ​ Name: ​ Title: ​ ​ ​ [ACKNOWLEDGMENT ON THE FOLLOWING PAGE] ​ ​ ​ ACKNOWLEDGMENT ​ ​ [PROPER FORM OF ACKNOWLEDGMENT TO BE INSERTED] ​ ​ [SIGNATURES CONTINUE ON THE FOLLOWING PAGE] ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ L0E1G0A3L9_6US-1_E6#9142-117658098494.3-Active.19224474.4 ​ ​ ​ EXHIBIT A - DESCRIPTION OF PROPERTY ​ ​ [to be inserted] ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ K-1- ​ ​ Exhibit 21.1Subsidiaries of La Jolla Pharmaceutical CompanyName of Subsidiary JurisdictionLa Jolla Pharmaceutical I B.V. NetherlandsLa Jolla Pharmaceutical II B.V. NetherlandsLa Jolla Pharmaceutical III B.V. NetherlandsExhibit 23.1CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMWe consent to the incorporation by reference in Registration Statements (No. 333-206855) on Form S-3 and (No. 333-207212) on Form S-8 of La JollaPharmaceutical Company of our report dated February 23, 2017, relating to our audits of the consolidated financial statements and internal control overfinancial reporting, which appear in this Annual Report onForm 10-K of La Jolla Pharmaceutical Company for the year ended December 31, 2016./s/ SQUAR MILNER LLPSan Diego CaliforniaFebruary 23, 2017EXHIBIT 31.1SECTION 302 CERTIFICATIONI, George F. Tidmarsh, certify that:1.I have reviewed this Annual Report on Form 10-K of La Jolla Pharmaceutical Company;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by thisreport;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects thefinancial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,to ensure that material information relating to the registrant, including its subsidiaries, is made known to us by others within those entities,particularly during the period in which this report is being prepared;b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under oursupervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements forexternal purposes in accordance with generally accepted accounting principles;c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s mostrecent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likelyto materially affect, the registrant’s internal control over financial reporting; and5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, tothe registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internalcontrol over financial reporting. Date:February 23, 2017/s/ George F. Tidmarsh George F. Tidmarsh, M.D., Ph.D. President, Chief Executive Officer and Secretary (Principal Executive Officer)EXHIBIT 31.2SECTION 302 CERTIFICATIONI, Dennis M. Mulroy, certify that:1.I have reviewed this Annual Report on Form 10-K of La Jolla Pharmaceutical Company;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by thisreport;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects thefinancial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,to ensure that material information relating to the registrant, including its subsidiaries, is made known to us by others within those entities,particularly during the period in which this report is being prepared;b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under oursupervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements forexternal purposes in accordance with generally accepted accounting principles;c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s mostrecent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likelyto materially affect, the registrant’s internal control over financial reporting; and5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, tothe registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; andb.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internalcontrol over financial reporting. Date:February 23, 2017/s/ Dennis M. Mulroy Dennis M. Mulroy Chief Financial Officer (Principal Financial and Accounting Officer)EXHIBIT 32.1CERTIFICATION PURSUANT TO18 U.S.C. SECTION 1350,AS ADOPTED PURSUANT TOSECTION 906 OF THE SARBANES-OXLEY ACT OF 2002Each of the undersigned, in his capacity as an officer of La Jolla Pharmaceutical Company (the "Registrant"), hereby certifies, for purposes of 18 U.S.C.Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:•the Annual Report of the Registrant on Form 10-K for the quarter ended December 31, 2016 (the “Report), which accompanies this certification,fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and•the information contained in the Report fairly presents, in all material respects, the financial condition of the Registrant at the end of such quarterand the results of operations of the Registrant for such quarter. Date:February 23, 2017/s/ George F. Tidmarsh George F. Tidmarsh, M.D., Ph.D. President, Chief Executive Officer and Secretary (Principal Executive Officer) /s/ Dennis M. Mulroy Dennis M. Mulroy Chief Financial Officer (Principal Financial and Accounting Officer)Note: A signed original of this written statement required by Section 906 has been provided to La Jolla Pharmaceutical Company and will be retained by LaJolla Pharmaceutical Company and furnished to the Securities and Exchange Commission or its staff upon request.

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