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NuVasive

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FY2015 Annual Report · NuVasive
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NuVasive, Inc.
2015 Annual Report

LETTER TO SHAREHOLDERS

DEAR VALUED SHAREHOLDER,
2015 was a dynamic year for 
NuVasive, defined by solid 
execution, as well as numerous 
steps to establish an even 
stronger foundation from which 
to transform spine surgery with 
minimally invasive, procedurally-
integrated solutions that are 
expanding the boundaries 
of modern healthcare. 

IN THIS LETTER:

Report on 2015 

Strong Foundation for Future Growth

NuVasive Specialized Orthopedics

2016 Market Outlook

2016 Strategic Agenda

Industry-Leading Innovation

Share-Taking Revenue Growth

Increasing Profitability

NuVasive Spine Foundation

Confidence in the Future

Strong History of Growth and 
Increasing Profitability
Disciplined execution of strategy 
delivers exceptional results. 

GLOBAL REVENUE (IN MILLIONS)

$811.1

$762.4

$850

$800

$750

$700

$685.2

$650

$600

2013

2014

2015

NON-GAAP OPERATING PROFIT MARGIN*

17%

15%

13%

11%

9%

7%

5%

15.4%

11.4%

9.2%

2013

2014

2015

LETTER TO SHAREHOLDERS

REPORT ON 2015

Our category-focused innovation continued to lead the 
industry in 2015. In May 2015, we launched the biggest 
innovation platform since the introduction of XLIF® 
with Integrated Global Alignment, or iGA™, to address 
a critical element in successful spine surgery – proper 
alignment. In conjunction with iGA, we also entered the 
adult deformity market in a big way with Reline®, our 
comprehensive posterior fixation system. Both helped 
drive strong sequential improvements in the Company’s 
lumbar performance throughout the year, ending 2015 with 
our best U.S. results in years at nearly 10% growth for the 
fourth quarter. Additionally, we experienced a powerful 
resurgence in our cervical business with the success of 
our differentiated Archon® anterior plate and VuePoint® II 
fixation system, delivering upwards of 15% growth during 
the fourth quarter. 

Our performance in Asia Pacific continued its growth 
trajectory with exceptional expansion in NuVasive’s largest 
international markets of Japan and Australia, which offset 
weakness in Latin America and the Middle East. We were 
also very pleased with the positive momentum we are 
experiencing in Western Europe due to localized business 
plans that exploit the competitive advantage of our 
differentiated XLIF lateral access technology. This success in 
Europe, coupled with a fresh view of how we accelerate our 
globalization efforts, is setting the Company up for strong 
international performance in 2016. 

The cumulative effect of these factors drove NuVasive’s 
topline performance higher, delivering growth at multiples 
of the market – up 8.2% on a constant currency basis*, 
ending 2015 with record revenue of $811.1 million.

We also delivered record profitability for the year, with a 
400 basis point improvement in the Company’s non-GAAP 
operating profit margin* to 15.4% for 2015. This was driven 
by our continued dedication to capturing well-identified 
operating efficiencies to meaningfully improve operational 
execution, optimize global scale and rapidly bring 
profitability in line with the peer group. Our full year non-
GAAP earnings per share* performance nearly doubled over 
2014 results at $1.31, delivering on our commitment to grow 
earnings at a rate significantly faster than revenue.

As we continue to capture margin expansion 
opportunities and drive international scale, 
we expect to deliver significant profitability 
improvements in the years to come.

STRONG FOUNDATION FOR FUTURE GROWTH

Over the past year, we also worked to build a stronger 
foundation for growth, which included a number of 
deliberate steps to position NuVasive for even better results, 
starting with our leadership team. We made a number of 
new executive appointments to create a world-class team, 
including new leaders for International, Legal, Strategy & 
Corporate Development, Human Resources & Corporate 
Integrity, and Information Technology. 

Set to drive NuVasive’s next phase of growth 
and success as the innovation pioneer 
in spine, our leadership team reflects the 
deep bench of talent and expertise within 
NuVasive, as well as the addition of new 
individuals who bring complementary 
experience and proven records of execution. 

We also attracted high caliber leaders to further enhance  
the diverse skills of NuVasive’s Board of Directors with  
four exceptional new additions – Vickie Capps, Robert Friel, 
Donald Rosenberg and Dan Wolterman. As we continue  
to grow and mature as a Company, their collective years  
of experience across important industries will add a  
valuable perspective. 

Additionally, we took a number of steps to enhance the 
Company’s organizational alignment and accelerate our 
market share-taking strategy in the global spine market. 
This included the integration of the global products 
and services function with supply chain operations to 
ensure greater connection between procedural solution 
development and the efficient delivery of our offerings to 
the field. And, following the strategic integration of the 
U.S. sales and service functions, this newly combined 
organization emerged as U.S. Commercial, dedicated to 
driving NuVasive’s multi-faceted share-taking strategies.

We also made changes to how we manage our business  
on a day-to-day basis to bring enhanced oversight and 
increased accountability to every level of the organization. 
We have moved fast to put in place new processes  
and systems to fundamentally improve execution.  
This means a much more rigorous examination of  
where we spend money today, and what return we  
will get for the next incremental dollar of investment.  
As a result, we entered 2016 as a much more disciplined 
organization ready to do even bigger things. 

1

LETTER TO SHAREHOLDERS

NUVASIVE SPECIALIZED ORTHOPEDICS

2016 MARKET OUTLOOK

In February 2016, we completed the acquisition of Ellipse 
Technologies, Inc., which now operates under a newly 
created division called NuVasive Specialized Orthopedics™, 
or NSO. Through this acquisition, we acquired a highly 
scalable technology based on a MAGnetic External Control 
(MAGEC®) platform, which has exceptional growth prospects 
to redefine the entire concept of minimally invasive surgery. 

With MAGEC, NuVasive enters the early-onset scoliosis 
market with an important competitive advantage.  
The MAGEC system is an expandable growing rod that can 
be non-invasively distracted following implantation with 
precise, incremental adjustments via an external remote 
controller using magnetic technology. This cutting-edge 
technology reduces the need for repeat surgeries every 
six months which creates significant improvements to a 
patient’s quality of life, while also generating cost savings 
to the healthcare system. MAGEC not only provides us 
with immediate access to the early-onset and adolescent 
scoliosis market, which we did not participate in previously, 
but also opens the door for additional growth with the 
pull-through of NuVasive products into these procedures. 

We think scoliosis is just the start for how our MAGEC 
technology can be applied to spine and orthopedic 
surgery. Already, the external magnetic control concept 
has led to the launch of the PRECICE® limb lengthening 
system, which allows for the correction of long bone limb 
length discrepancy, as well as enhanced bone healing 
in patients that have experienced traumatic injury. 

The pipeline of products from NSO promises 
to be strong as we look to exploit the 
core MAGEC technology to meaningfully 
broaden the surgical applications of its highly 
differentiated expandable drive mechanism.

This will include ongoing innovation to fortify our  
deformity portfolio, expand our tumor and trauma 
offerings, in addition to exploring novel spinal applications 
that further NuVasive’s focus on improving spine care.

There is no doubt we are operating in a rapidly changing 
healthcare environment that is becoming ever more 
complex. With an increasing amount of market influencers 
to navigate, NuVasive’s ability to clearly demonstrate clinical 
and economic value has never been more important. 

From a patient perspective, it is fair to say that spine surgery 
is one of the most dreaded medical procedures, something 
an individual will often put off as long as possible. And yet, 
when a patient is well-selected and the procedure is done 
correctly, it can restore the vitality of life like nothing else. 

Our mission at NuVasive is to fundamentally 
change both the reality and perception of 
spine surgery by converting skilled surgeons to 
ever-increasing minimally invasive techniques. 

In time, we intend to take our message directly to the 
patient to educate and instill confidence that those who 
suffer from spine conditions can benefit from better 
surgical outcomes that improve their quality of life.

We also have a new vision for comprehensive spinal health 
that permeates our commercial strategies. Central to 
this effort will be our strategic move from being a vendor 
focused on transactions around products to becoming a 
true partner focused on transforming how spine procedures 
are approached, measured and valued from a clinical and 
economic perspective. Today, we know that spine-related 
procedures are a clear source of profitability for hospitals, 
and yet the providers’ ability to accurately measure that 
performance, let alone impact it for the better, can be 
limited. We possess deep industry knowledge around the 
true benefits of spine surgery and look to partner with 
the leadership of healthcare systems to create highly 
appealing and competitive spine franchises through the 
implementation of our proprietary service line programs. 

At the core of these service line programs is NuVasive’s ability 
to deliver an end-to-end, procedurally-integrated solution 
where the defining success factors of the surgery can be 
impacted like never before. Beginning with capabilities 
to accurately diagnose spinal conditions, to empowering 
surgeons with technology to plan surgeries in the least 
disruptive way possible, to an intraoperative reconciliation 
system to ensure the surgical plan is successful before  
the patient leaves the operating room, to finally utilizing  
post-operative protocols to measure clinical value.  
We believe NuVasive’s integrated approach and expertise 
can fundamentally evolve spine care. These programs will 
not only enable hospitals to survive turbulent healthcare 
changes, but more importantly thrive and grow.

2

LETTER TO SHAREHOLDERS

2016 STRATEGIC AGENDA

Looking ahead to 2016 and beyond, we will continue 
to execute against our clear formula for success:

1.  Driving innovation that addresses unmet clinical needs 

and improves clinical and economic outcomes.

2.  Driving organic growth in the U.S. and internationally, 
while also pursuing strategic M&A that strengthens 
and deepens our leadership in spine.

3  Delivering increased profitability 
through operational excellence. 

INDUSTRY-LEADING INNOVATION

As a spine industry leader, NuVasive is dedicated to 
developing disruptive technologies designed to provide 
reproducible and clinically-proven surgical outcomes. 
Addressing a variety of pathologies, from complex 
spinal deformity to degenerative spinal conditions, 
our highly differentiated solutions increase the value 
of care by delivering a better patient experience and 
better economics for the healthcare system. 

There are those that say spine is destined to become 
a commodity. It is what happens when complacency 
overrides a company’s curiosity to look deeper into its 
environment. Curiosity – not complacency – resides 
at the very heart of NuVasive and explains our fierce 
competitiveness. When you consider the possibilities 
of our iGA expert system, or the potential of imaging 
and navigation technologies to allow for even greater 
surgical clarity and precision, or designing implants that 
uniquely fit the patient, at NuVasive we believe we have 
barely scratched the surface of what can be achieved.

To that end, innovation will be our constant, enabling 
NuVasive to operate at a generation above the competitive 
set. In 2016, we expect to deliver innovation up and down 
the spine with new products and line extensions for 
NuVasive’s core anterior and posterior thoracolumbar 
applications, as well as innovation for cervical offerings, 
including iGA for cervical spine procedures. We also 
look to fuel our R&D pipeline by further exploiting NSO’s 
innovative MAGEC magnetic technology platform to 
address broader spine and niche orthopedic applications. 

We firmly believe that the future of spine surgery belongs 
to those surgeons and hospital systems that can emphasize 
minimally invasive surgery. NuVasive will remain the leading 
innovator around less disruptive techniques and you will 
see even more technology advancements forthcoming.

SHARE-TAKING REVENUE GROWTH

We will continue to drive revenue growth at 
multiples of the market by remaining laser-focused 
on our strategic market share-taking efforts. 

Organic growth in our core spinal hardware business, 
and pull-through of biologics and monitoring services, 
will come through an unrelenting focus on unique 
commercialization strategies. Our work will center on 
compelling surgeon and hospital customers to use more 
NuVasive technology and services by clearly demonstrating 
the clinical and economic value of our procedurally-
integrated offerings. Key initiatives will include enhanced 
surgeon conversion, a push to win national strategic 
accounts, as well as securing service line partnerships. 

Additionally, we will look to optimize our globalization 
initiatives to nearly double revenue contribution from 
our international business in the coming years. In 
2016, this includes a deeper penetration in markets 
like Japan, Australia, Italy, Germany and the United 
Kingdom. This will be achieved by engaging more local 
thought leaders in a “tip of the spear” approach that 
begins to influence increased adoption of NuVasive’s 
differentiated technology. We will deliver more in-market 
training directly to existing and competitive surgeons 
around the globe through expanded training capabilities 
in Amsterdam, Australia, Hong Kong and Singapore. 

We also have a very active corporate development 
pipeline that includes acquisition targets, strategic 
partnerships and out-of-the-box thinking to broaden 
NuVasive’s participation along the spine care continuum. 
Top priorities include opportunities that complement 
our technology leadership position in spine, targeted 
geographic expansion, as well as ways to further 
enhance our end-to-end offerings – just to name a few. 

Most importantly, we intend to be disciplined 
and highly selective in our M&A approach 
and remain focused on  shareholder value. 

This means we will not only seek targets that are a 
great strategic fit, but look to also meet our return 
on invested capital goals – within three years for 
smaller deals, and five years for larger transactions.

3

LETTER TO SHAREHOLDERS

INCREASING PROFITABILITY 

NUVASIVE SPINE FOUNDATION

We remain committed to driving profitability much 
higher. Plans are in place to deliver nearly 1,000 basis 
points of improvement in our non-GAAP operating profit 
margins* as we move beyond $1 billion in revenues. This 
significantly increased profit performance will be driven 
by a tighter management of our business, including a clear 
focus on reducing the cost to manufacture our products, 
asset utilization and improving sales force efficiencies.

There are tremendous efficiencies we can gain by 
improving the management of spine surgical sets that 
are delivered to support each surgery. We are pleased 
to report that in the last twelve months we have made 
substantial progress reducing back orders and late 
deliveries. More importantly, these early changes are 
setting the foundation for a dramatic improvement in 
our supply chain efficiency over the next 36 months. 

Additionally, increasing our in-house manufacturing 
capabilities to 100% of select products will be a particularly 
meaningful source of margin expansion – delivering 
approximately 400 basis points of improvement over 
the next several years. Key to our efforts will be the 
development of our newly acquired facility in West 
Carrollton, Ohio. Improvements to the building have 
begun and recruiting efforts are well underway as we 
work to have our manufacturing facility up and running by 
the end of 2016 and at full capacity by the end of 2017. 

International scalability will be another profitability driver 
in 2016. With our localized and differentiated surgeon 
conversion plans now in place in Western Europe, we have 
experienced particularly encouraging results. In markets 
like Germany, we saw near 30% growth in revenue for the 
fourth quarter 2015 – setting us up for a strong international 
performance in 2016 as these strategies take hold. We are 
layering in the added benefit of the geographic strength 
we gain from NSO’s highly differentiated offerings to 
drive volume growth in certain countries as well.

*Indicates non-GAAP financial information. Please refer to accompanying 
“Non-GAAP Information” included at the end of this annual report.

4

As an organization, we are dedicated to driving our financial 
performance. However, beyond the dollars and cents,  
we are also operating at an even deeper level. NuVasive 
has an incredibly strong corporate culture and one that 
exemplifies an “attitude of gratitude” spirit that embraces 
giving back to the community. It is this core value that 
served as the basis for forming the NuVasive Spine 
Foundation™ in 2009. The NuVasive Spine Foundation is a 
non-profit organization dedicated to supporting medical 
missions across the globe, training spine surgeons in 
disadvantaged communities, working with local teams 
to develop sustainable spine treatment programs and 
providing assistance to spine patients in the U.S. Since 
its inception and through 2015, we are pleased to report 
that the NuVasive Spine Foundation has been able 
to provide life-changing surgeries for more than 850 
patients in need in over 30 countries, in addition to more 
than 600 hours spent training local surgeons so they 
can continue to serve their communities. We are very 
gratified to be able to continue our work in regions of need 
across the globe and provide advanced care through the 
tremendous efforts of the NuVasive Spine Foundation.

CONFIDENCE IN THE FUTURE

We are set up for a strong 2016 and are bullish about our 
long-term prospects. Our positive outlook is driven by a 
focus on reimagining the spine space – thinking in terms of 
transformation at every level to deliver exceptional clinical 
and economic value. The need for spine surgery is not going 
away, and the drive to improve the patient experience and 
change lives for the better has never been more relevant. 

NuVasive has an impressive history built on blazing 
innovative paths in the spine industry that created an  
entirely new way to do spine surgery with our first-to-market 
lateral access technology. At the time, virtually every thought 
leader in the game believed it could not work, and even  
the largest incumbent competitors dismissed the concept.  
That heritage of not listening to what is conventional, or what 
others believe cannot be done, permeates our NuVasive 
culture. It powers our future and fuels our unrelenting belief 
that we can be the best in spine, and someday, become first. 

Thanks for your continued interest and support.

Gregory T. Lucier 
Chairman and Chief Executive Officer

Patrick S. Miles 
President and Chief Operating Officer

UNITED STATES 
SECURITIES AND EXCHANGE COMMISSION  
Washington, D.C. 20549  

Form 10-K  

 (Mark One)  
  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934  

For the fiscal year ended December 31, 2015  

OR  

  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934  

For the transition period from                      to                       

Commission file number: 000-50744  

NUVASIVE, INC.  

(Exact name of registrant as specified in its charter)  

Delaware 
(State or other jurisdiction of 
incorporation or organization) 

7475 Lusk Boulevard 
San Diego, California 
(Address of principal executive offices) 

33-0768598 
(I.R.S. Employer 
Identification No.) 

92121 
(Zip Code) 

 (858) 909-1800  

(Registrant’s telephone number, including area code)  
Securities registered pursuant to Section 12(b) of the Act  

Title of Class: 
Common Stock, par value $0.001 per share 

Name of Exchange on which Registered: 
The NASDAQ Stock Market LLC 
(NASDAQ Global Select Market) 

Securities registered pursuant to Section 12(g) of the Act: None 

Indicate  by  check  mark  if  the  registrant  is  a  well-known  seasoned  issuer,  as  defined  in  Rule 405  of  the  Securities  Act  of  1933,  as 

amended.    YES      NO    

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934, 

as amended.    YES      NO    

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 
1934 during the preceding 12 months (or for such shorter period than the registrant was required to file such reports), and (2) has been subject to such filing 
requirements for the past 90 days.    YES      NO    

Indicate  by  check  mark  whether  the  registrant  has  submitted  electronically  and  posted  on  its  corporate  website,  if  any,  every  Interactive  Data  File 
required to be submitted and posted pursuant to Rule 405 of Regulation S-T (Section 232.405 of this chapter) during the preceding 12 months (or for such 
shorter period that the registrant was required to submit and post such files).    YES      NO    

Indicate  by  check  mark  if  disclosure  of  delinquent  filers  pursuant  to  Item 405  of  Regulation S-K  (Section  229.405  of  this  chapter)  is  not  contained 
herein, and will not be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of 
this Form 10-K or any amendment to this Form 10-K.    

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. 

See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):  

Large accelerated filer 

   

   Accelerated filer 

Non-accelerated filer 

    (Do not check if a smaller reporting company) 

   Smaller reporting company 

  

  

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YES  NO   
The aggregate market value of the voting and non-voting common equity held by non-affiliates of the registrant was approximately $2.3 billion as of 
the last business day of the registrant’s most recently completed second fiscal quarter (June 30, 2015), based upon the closing sale price for the registrant’s 
common stock on that day as reported by the NASDAQ Global Select Market. Shares of common stock held by each officer and director on June 30, 2015 
have been excluded in that such persons may be deemed to be affiliates.  

As of February 8, 2016, there were 49,691,101 shares of the registrant’s common stock issued and outstanding.  

Part III of this Form 10-K incorporates information by reference to portions of the definitive Proxy Statement for the registrant’s 2016 Annual Meeting 

of Stockholders, which will be filed with the U.S. Securities and Exchange Commission not later than 120 days after December 31, 2015.  

DOCUMENTS INCORPORATED BY REFERENCE  

  
  
 
  
  
 
 
  
 
  
 
  
 
 
 
 
 
 
 
  
  
 
 
 
 
[THIS PAGE INTENTIONALLY LEFT BLANK]

Annual Report on Form 10-K for the Fiscal Year ended December 31, 2015  

NuVasive, Inc.  

Table of Contents 

PART I

Item 1. 
   Business ............................................................................................................................................................................   
Item 1A.    Risk Factors ......................................................................................................................................................................   
Item 1B.    Unresolved Staff Comments .............................................................................................................................................   
   Properties ..........................................................................................................................................................................   
Item 2. 
   Legal Proceedings ............................................................................................................................................................   
Item 3. 
   Mine Safety Disclosures ...................................................................................................................................................   
Item 4. 

PART II 

Item 5. 
   Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities .......   
   Selected Financial Data ....................................................................................................................................................   
Item 6. 
   Management’s Discussion and Analysis of Financial Condition and Results of Operations ...........................................   
Item 7. 
Item 7A.    Quantitative and Qualitative Disclosures About Market Risk ..........................................................................................   
   Financial Statements and Supplementary Data.................................................................................................................   
Item 8. 
   Changes in and Disagreements With Accountants on Accounting and Financial Disclosure ..........................................   
Item 9. 
Item 9A.    Controls and Procedures ...................................................................................................................................................   
Item 9B.    Other Information .............................................................................................................................................................   

Item 10.     Directors, Executive Officers and Corporate Governance ................................................................................................   
Item 11.     Executive Compensation ..................................................................................................................................................   
Item 12.     Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters .........................   
Item 13.     Certain Relationships and Related Transactions, and Director Independence ..................................................................   
Item 14.     Principal Accounting Fees and Services ...........................................................................................................................   

PART III 

Item 15.     Exhibits, Financial Statement Schedules ..........................................................................................................................   
SIGNATURES .................................................................................................................................................................................    
Index to Consolidated Financial Statements ....................................................................................................................................    

PART IV 

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PART I 

This  Annual  Report  on  Form 10-K  (“Annual  Report”)  contains  forward-looking  statements  that  involve  risks,  uncertainties, 
assumptions  and  other  factors  which,  if  they  do  not  materialize  or  prove  correct,  could  cause  our  results  to  differ  from  historical 
results  or  those  expressed  or  implied  by  such  forward-looking  statements.  In  some  cases,  you  can  identify  these  forward-looking 
statements  by  words  like  “may”,  “will”,  “should”,  “could”,  “expect”,  “plan”,  “anticipate”,  “believes”,  “estimates”,  “predicts”, 
“potential”, “intends”, or “continues” (or the negative of those words and other comparable words).  Forward-looking statements 
include, but are not limited to, statements about: 

•  our intentions, beliefs and expectations regarding our expenses, sales, operations and future financial performance; 
•  our operating results; 
•  our plans for future products and enhancements of existing products; 
•  anticipated growth and trends in our business; 
•  the timing of and our ability to maintain and obtain regulatory clearances or approvals; 
•  our belief that our cash and cash equivalents and investments will be sufficient to satisfy our anticipated cash requirements; 
•  our expectations regarding our revenues, customers and distributors;  
•  our beliefs and expectations regarding our market penetration and expansion efforts; 
•  our  expectations  regarding  the  benefits  and  integration  of  recently-acquired  businesses  and  our  ability  to  make  future 

acquisitions and successfully integrate any such future-acquired businesses; 
•  our anticipated trends and challenges in the markets in which we operate; and  
•  our expectations and beliefs regarding and the impact of investigations, claims and litigation.   

These  statements  are  not  guarantees  of  future  performance  or  events.  Our  actual  results  may  differ  materially  from  those 
discussed  in  this  Annual  Report  and  the  documents  incorporated  by  reference  to  this  Annual  Report.  The  potential  risks  and 
uncertainties  that  could  cause  actual  results  to differ  materially  include,  but are not  limited  to,  those  set  forth  in  Part  I, Item 1(A) 
under  the  heading  “Risk  Factors”,  Part  II,  Item  7  “Management’s  Discussion  and  Analysis  of  Financial  Condition  and  Results  of 
Operations”  and  elsewhere  throughout  this  Annual  Report  and  in  any  other  documents  incorporated  by  reference  to  this  Annual 
Report. Readers are cautioned not to place undue reliance on such forward-looking statements.  We assume no obligation to update 
any forward-looking statements to reflect new information, future events or circumstances or otherwise, except as required by law.   

This Annual Report and the documents incorporated by reference into this Annual Report refer to trademarks, such as Absolute 
Responsiveness®,  Acuity®,  Affix®,  Armada®,  AttraX®,  Back  Pact®,  Bendini®,  Better  Back  Alliance®,  Better  Insight.  Better 
Decisions.  Better  Medicine®,  Brigade®,  CerPass®,  CoRoent®,  Creative  Spine  Technology®,  DBR®,  Embody®,  Embrace®, 
ExtenSure®, Formagraft®, Gradient Plus®, Halo®, ILIF®, InStim®, Leverage®, MAGEC®, MAGEC-EOS™, MAS®, MaXcess®, 
NeoDisc™,  Nerve  Avoidance  Leader™,  NuvaMap™,  NuvaLine™,  NuvaMap™  O.R.,  NuVasive®,  NVM5®,  Osteocel®,  Precept®, 
PRECICE®,  PROPEL®,  Radian®,  Reline™,  Speed  of  Innovation®,  SpheRx®,  The  Better  Way  Back®,  Traverse®,  Triad®, 
VuePoint®,  X-Core®,  and  XLIF®,  which  are  protected  under  applicable  intellectual  property  laws  and  are  our  property  or  the 
property of our subsidiaries. Solely for convenience, our trademarks and tradenames referred to in this Annual Report may appear 
without the ® or ™ symbols, but such references are not intended to indicate in any way that we will not assert, to the fullest extent 
under applicable law, our rights to these trademarks and tradenames. 

Item 1. 

Business  

Overview  

We  are  a  leading  medical  device  company  in  the  global  spine  surgery  market,  focused  on  developing  minimally-disruptive 
surgical  products  and  procedurally-integrated  solutions  for  spine  surgery.  Our  currently-marketed  product  portfolio  is  focused  on 
applications for spine fusion surgery, including biologics used to aid in the spinal fusion process. For the year ended December 31, 
2015, we generated global revenues of $811.1 million, including sales in over 30 countries. 

2 

 
 
Our  principal  product  offering  includes  a  minimally-disruptive  surgical  platform  called  Maximum  Access  Surgery,  or  MAS. 
The MAS platform combines three categories of solutions that collectively minimize soft tissue disruption during spine fusion surgery, 
provide  maximum  visualization  and  are  designed  to  enable  safe  and  reproducible  outcomes  for  the  surgeon  and  the  patient.  The 
platform includes our proprietary software-driven nerve detection and avoidance systems, NVM5, and Intraoperative Monitoring, or 
IOM,  services  and  support;  MaXcess,  an  integrated  split-blade  retractor  system;  and  a  wide  variety  of  specialized  implants  and 
biologics. Many of our products, including the individual components of our MAS platform can also be used in open or traditional 
spine  surgery.  Our  spine  surgery  product  line  offerings,  which  include  products  for  the  thoracolumbar  and  the  cervical  spine,  are 
primarily used to enable surgeon access to the spine to perform restorative and fusion procedures in a minimally-disruptive fashion.  
We also recently launched Integrated Global Alignment, or iGA, in which products and computer assisted technology under our MAS 
platform  help  achieve  more  precise  spinal  alignment.  Our  biologics  products,  which  are  used  to  aid  in  the  spinal  fusion  process  or 
bone  healing  process  include  allograft  (donated  human  tissue)  and  synthetic  offerings.    In  addition,  following  our  acquisition  of 
Ellipse  Technologies,  Inc.,  or  Ellipse  Technologies,  which  closed  in  February  2016,  we  now  offer  magnetically  adjustable  implant 
systems based on the MAGnetic External Control, or MAGEC, technology platform. We continue to focus significant research and 
development efforts to expand our MAS product platform and advance the applications of our unique technology into procedurally-
integrated  surgical  solutions  that  improve  clinical  and  economic  outcomes.  We  have  dedicated  and  continue  to  dedicate  significant 
resources toward training spine surgeons around the world; both those who are new to our MAS product platform, as well as ongoing 
education for MAS-trained surgeons attending advanced courses.   

We  believe  our  MAS  platform  and  its  related  offerings  provide  a  unique  and  comprehensive  solution  for  the  safe  and 
reproducible  minimally-disruptive  surgical  treatment  of  spine  disorders  by  enabling  surgeons  to  access  the  spine  in  a  manner  that 
affords  both  direct  visualization  and  detection  and  avoidance  of  critical  nerves.  The  fundamental  difference  between  our  MAS 
platform, which is sometimes referred to in the industry as “minimally invasive surgery” or “MIS”, is the ability to customize safe and 
reproducible access to the spine while allowing surgeons to continue to use instruments that are familiar to them and effective during 
surgery.  Accordingly,  the  MAS  platform  does  not  force  surgeons  to  reinvent  or  learn  new  approaches  that  add  complexity  and 
undermine  safety,  ease  of  use  and/or  efficacy.  An  important  ongoing  objective  of  ours  has  been  to  maintain  a  leading  position  in 
access  and  nerve  avoidance,  as  well  as  to  pioneer  and  remain  the  ongoing  leader  in  minimally  invasive  spine  surgery.  Our  MAS 
platform,  with  the  unique  advantages  provided by our nerve  monitoring systems,  enables  an  innovative  lateral  procedure known  as 
eXtreme Lateral Interbody Fusion, or XLIF, in which surgeons access the spine for a fusion procedure from the side of the patient’s 
body, rather than from the front or back. It has been demonstrated clinically that XLIF and other procedures facilitated by our MAS 
platform decrease trauma and blood loss, and lead to faster overall patient recovery times compared to open spine surgery.  

Our corporate headquarters is located in San Diego, California where we occupy approximately 146,000 square feet, including a 
six-suite  state-of-the-art  cadaver  operating  theatre  designed  to  accommodate  the  training  of  spine  surgeons.  Our  location  in 
Amsterdam, the Netherlands, serves as our international headquarters. Our IOM services and support business is operated through our 
subsidiary, Impulse Monitoring, Inc., or Impulse Monitoring, which is located in Columbia, Maryland. Our primary distribution and 
warehousing operations are located in our facility in Memphis, Tennessee. Our business is facilitated by rapid delivery of products and 
surgical instruments for surgeries involving our products. Because of its location and proximity to overnight third-party transporters, 
our  Memphis  facility  enhances  our  ability  to  meet  demanding  delivery  schedules  and  provide  a  greater  level  of  customer  service. 
Additionally, we have a manufacturing facility located in Dayton, Ohio that produces spinal implants. In furtherance of our initiative 
to increase the amount of products that we self-manufacture, in 2015 we added an approximately 179,000 square foot manufacturing 
facility in Dayton, Ohio and announced our plans to build out and equip the new facility in order to expand our internal manufacturing 
efforts.  

Our Strategy  

We  are  a  leading  provider  of  innovative  medical  products  that  provide  comprehensive  solutions  for  the  surgical  treatment  of 

spine disorders. We continue to pursue the following business strategies in order to improve our competitive position:  

  Establish our MAS Platform as the Standard of Care. We believe our MAS platform has the potential to become the standard 
of  care  for  spine  surgery  as hospitals, providers  and  spine  surgeons  continue  to  recognize  its  many  benefits  and  adopt our 
products and procedures. We also believe that our MAS platform has the potential to dramatically improve the clinical results 
of  spine  surgery.  Because of  this  belief, we  dedicate  significant resources  to  researching  clinical  outcomes  data  as  well  as 
educating  spine  surgeons,  hospitals,  and  other  providers  and  their  patients  on  the  clinical  and  financial  benefits  of  our 
products, and we intend to capitalize on the growing demand for minimally-disruptive surgical procedures.  

3 

 
 
  Continue  to  Develop  and  Introduce  Procedurally-Integrated  Solutions  and  New  Innovative  Products. One  of  our  core 
competencies is our ability to rapidly develop and commercialize innovative spine surgery products and procedures to fulfill 
an  unmet  clinical  need.  In  the  past  several  years,  we  have  introduced  a  continual  flow  of  new  products  and  product 
enhancements.  We  have  additional  products  and  procedural  offerings  currently  under  development  that  should  expand  our 
presence in fusion surgery. With our comprehensive portfolio of product and service offerings, we believe that we can offer 
our  customers  a  comprehensive  procedural  solution  for  spine  surgery  that  distinguishes  us  from  traditional  spine  implant 
companies.  We  intend  to continue  to  build  upon our  procedural solution  with new and  enhanced technology offerings,  as 
well  as  product  expansions.  We  believe  that  through  continued  innovation  and  a  focus  on  providing  comprehensive 
procedural solutions for our customers, we will increase our market share while at the same time improving patient care. As 
part  of  this  strategy,  the  Company  must  continue  to  protect  and  defend  its  intellectual  property  related  to  our  innovative 
products.  

  Expand the Reach of Our Exclusive Sales Force. We believe that having a sales force dedicated to selling only our products 
is critical to achieving continued growth across our various product lines, driving greater market penetration and increasing 
our  revenues.  In  the  United  States,  we  have  an  exclusive  sales  force  consisting  of  a  mix  of  directly-employed  sales 
representatives and exclusive sales agents that are responsible for particular geographic regions of the country. Outside of the 
United  States,  our  sales  force  consists  of  directly-employed  sales  representatives,  independent  sales  agents  and  territory-
based distributors. We believe that continuing to expand the range of such teams will allow us to increase our market share 
while and drive adoption of our products and procedures. 

  Provide  Tailored  Solutions  in  Response  to  Surgeon  Needs. Responding  quickly  to  the  needs  of  spine  surgeons,  which  we 
refer to as “Absolute Responsiveness”, is central to our corporate culture, critical to our success, and we believe differentiates 
us from our competition. We solicit information and feedback from our surgeon customers and clinical advisors regarding the 
utility of, and potential improvements to, our products. For example, we have an on-site machine shop to allow us to rapidly 
manufacture product prototypes and a state-of-the-art cadaver operating theatre in San Diego, California to provide clinical 
training  and  validate  new  ideas  through  prototype  testing.  We  also  maintain  regional  training  facilities  and  centers  for 
excellence  in  strategic  locations  around  the  globe.  Absolute  Responsiveness  goes  beyond  product  development  to  include 
active support in all areas, including clinical research and payer relations.  We believe that continuing to remain connected 
and  responsive  to  the  collective  voices  of  the  surgeon  community  will  allow  us  to  increase  our  market  share  and  drive 
adoption of our procedurally-integrated spine solutions. 

  Selectively License or Acquire Complementary Products and Technologies and Drive our International Presence. In addition 
to building our company through internal product development and global expansion efforts, we intend to selectively license 
or acquire complementary products and technologies that we believe will keep us on the forefront of innovation and to pursue 
opportunities  that  allow  us  to  expand  our  presence  in  emerging  geographical  opportunities.  For  example,  following  our 
February  2016  acquisition  of  Ellipse  Technologies,  we  now  offer  innovative  products  based  on  the  MAGEC  technology 
platform.    With  this  acquisition,  we  accelerated  our  entry  into  the  pediatric  and  idiopathic  spine  deformity  segment  and 
expanded  our  international  presence.  By  acquiring  complementary  products  and  executing  on  domestic  and  international 
footprint  opportunities,  we  believe  we  can  leverage  our  expertise  at  bringing  new  products  to  market  that  are  intended  to 
improve patient outcomes, simplify or better integrate techniques, reduce hospitalization and rehabilitation times across the 
globe, and, as a result, reduce overall costs to the healthcare system and continue to grow our global presence.  

  Provide Intraoperative Monitoring Capabilities. Monitoring the health of the nervous system during spinal surgery has been 
a key component of our strategy of product differentiation since early in our development. Over time, surgeon and hospital 
demand  for nerve  monitoring  has  increased  along with  the  advancement  of  technologies  and  techniques used  in IOM. We 
believe that our proprietary NVM5 platform is a differentiator in the market and is unique in its ability to provide information 
about the directionality and proximity of nerves. We intend to continue to expand the utility of such platforms and broaden 
our IOM offerings to further our value to our customers and increase adoption and usage. 

4 

 
 
Industry Background and Market  

The spine is the core of the human skeleton, and provides a crucial balance between structural support and flexibility. It consists 
of 33 separate bones called vertebrae that are connected together by connective tissue (defined as bone, muscle, or ligament) to form a 
column  and  to  permit  a  normal  range  of  motion.  The  spinal  cord,  the  body’s  central  nerve  system,  is  enclosed  within  the  spinal 
column. Vertebrae are paired into what are called motion segments that move by means of three joints: two facet joints and one spine 
disc. The four major categories of spine disorders are degenerative conditions, deformities, trauma and tumors. The largest market and 
the  focus  of  our  business  historically  are  degenerative  conditions  of  the  facet  joints  and  the  intervertebral  disc  space.  These  two 
conditions  can  result  in  instability  and  pressure  on  the  nerve  roots  as  they  exit  the  spinal  column,  causing  back  or  neck  pain  or 
radiating pain in the arms or legs.  

The prescribed treatment for back or neck pain depends on the severity and duration of the disorder. Initially, physicians will 
prescribe  non-operative,  conservative  procedures  including  bed  rest,  medication,  lifestyle  modification,  exercise,  physical  therapy, 
chiropractic  care  and  steroid  injections.  In  many  cases,  non-operative  treatment  options  are  effective;  however,  some  patients 
eventually require spine fusion surgery. The vast majority of spine fusion surgeries are done using traditional open surgical techniques 
from  either  the  front  or  back  of  the  patient.  These  traditional  open  surgical  approaches  generally  require  a  large  incision  in  the 
patient’s abdomen or back in order to enable the surgeon to access and see the spine and surrounding area. These open procedures are 
invasive,  lengthy  and  complex,  and  typically  result  in  significant  blood  loss,  extensive  tissue  damage  and  lengthy  patient 
hospitalization and rehabilitation.  

We believe that the market for procedurally-integrated spine surgery solutions will continue to grow over the long term, and we 

also believe that our market share will increase, because of the following market dynamics:  

  Demand for Surgical Alternatives with Less Tissue Disruption. As has been proven in other surgical markets, we anticipate 
that  the  broader  acceptance  of  surgical  treatments  with  less  tissue  disruption  and  patient  trauma  will  result  in  increased 
demand.  

  Favorable Domestic Demographics. The population segment most likely to experience back pain is expected to increase as a 
result  of  aging  “baby  boomers”  (people  born  between  1946  and  1965).  We  believe  this  large  population  segment  will 
increasingly demand a quicker return to activities of daily living following surgery than prior generations.  

  Access to Care in Emerging Markets. Health care reforms in many emerging markets are expanding access to treatments to a 
greater proportion of their populations, which we believe will continue to drive strong increases in demand for healthcare-
related product volumes. Increasing economic affluence in key developing regions will further drive demand for health care 
treatments.  

Although  we  believe  that  the  market  for  procedurally-integrated  spine  surgery  solutions  will  continue  to  grow  over  the  long 
term, economic, political and regulatory influences are subjecting our industry to significant changes that may slow the growth rate of 
the spine surgery market.  

Surgical Alternatives with Less Tissue Disruption  

The benefits of minimally invasive surgery procedures in other areas of orthopedics have significantly contributed to the strong 
and growing demand for surgical alternatives with less tissue disruption of the spine. Surgeons and hospitals seek spine procedures 
that result in fewer operative and postoperative complications and decreased patient hospitalization periods. At the same time, patients 
seek procedures that reduce trauma, allow for faster recovery times and result in more favorable clinical outcomes. Despite patient and 
doctor demands, the rate of adoption of alternative surgical procedures with less tissue disruption has been relatively slow with respect 
to the spine. Currently, the majority of spine surgery patients are treated with traditional open and invasive techniques.  

We believe the principal factor contributing to spine surgeons’ slow adoption of traditional minimally invasive spine alternatives 
has  been  inconsistent  outcomes  driven  by  the  limited  or  lack  of  direct  access  to  and  visibility  of  the  surgical  anatomy,  and  the 
associated  complex  instruments  that  have  been  required  to  perform  these  procedures.  Most  traditional  minimally  invasive  spine 
surgery  systems  do  not  allow  the  surgeon  to  directly  view  the  spine  and  the  relevant  pathology  point  and,  as  such,  provide  only 
restrictive  visualization  through  a  camera  system  or  endoscope,  while  also  requiring  the  use  of  complex  surgical  techniques.  In 
addition,  most  traditional  minimally  invasive  spine  surgery  systems  use  complex  or  highly  customized  surgical  instruments  that 
require special training and the completion of a large number of trial cases before the surgeon becomes proficient using the system, 
which is an impediment and/or deterrent to their adoption.  

5 

 
 
Our Commercial Products 

Our MAS platform allows surgeons to perform a wide range of minimally-disruptive spine procedures in all regions of the spine 
and from various surgical approaches, while overcoming the shortcomings of traditional minimally invasive spine surgical techniques. 
The  MAS  platform  is  designed  to  treat  a  wide  range  of  spinal  pathologies  while  accommodating  a  surgeon’s  preferred  surgical 
technique.  We  believe  our  approach  improves  clinical  results  and  should  continue  to  drive  an  expanded  number  of  minimally-
disruptive procedures performed, lead the market movement away from open surgery and make less invasive techniques the standard 
of care in spine fusion and non-fusion surgery.  

Our products facilitate minimally-disruptive applications of the following spine surgery procedures, among others:  
•  Lumbar  and  thoracic  fusion  procedures  in  which  the  surgeon  approaches  the  spine  through  the  patient’s  back,  side  or 

abdomen;  

•  Cervical fusion procedures for either the posterior occipito-cervico-thoracic region or the anterior cervical region; and 
•  Decompression, which is removal of a portion of bone or disc from over or under the nerve root to relieve pinching of the 

nerve. 

Our MAS platform combines three product categories: our MaXcess retractors, our specialized implants and fixation products, 
and our nerve monitoring systems and service offerings that collectively enable surgeons to detect and navigate around nerves while 
directing customized access to the spine for implant delivery. Biologics are used to complement procedures by assisting in the bone 
healing process. 

MaXcess 

MaXcess retractors have a split-blade design consisting of three blades that can be positioned to customize the surgical exposure 
in  the  shape  and  size  specific  to  the  surgical  requirements  rather  than  the  more  traditional  fixed  tube  or  two-blade  designs  of 
traditional minimally invasive spine surgical systems. This split-blade design also provides customizable access to the spine, which 
allows surgeons to perform surgical procedures using instruments that are similar to those used in open procedures but with a smaller 
incision and less tissue disruption. The ability to use familiar instruments reduces the learning curve for our procedures and facilitates 
the  adoption  of  our  products.  Our  system’s  illumination  of  the  operative  corridor  aids  in  providing  surgeons  with  better  direct 
visualization  of  the  patient’s  anatomy,  without  the  need  for  additional  technology  or  other  special  equipment  such  as  endoscopes.  
Over the years, several improvements to our MaXcess systems have been made, including incorporating integrated neuromonitoring 
technology  and  improving  the  blade  systems,  and  the  MAS  approach  has  broadened  from  the  lumbar  to  the  thoracic  region.  Our 
MaXcess products are used in the cervical spine for posterior application and anterior retraction, the lumbar spine for decompressions, 
transforaminal  lumbar  interbody  fusions,  or  TLIFs,  and  posterior  lumbar  interbody  fusions,  or  PLIFs,  the  thoracolumbar  spine  for 
eXtreme Lateral Interbody Fusion, or XLIFs, and the thoracic region for tumors and trauma, as well as in adult degenerative scoliosis 
procedures.  

Implants and Fixation Products 

 We have many implants and fixation devices designed to be used with our MAS platform. Our portfolio of implants used for 
interbody disc height restoration include implants made from allograft, titanium and polyetheretherketone, or PEEK.  Our CoRoent 
family  of  implants,  which  are  made  from  PEEK,  are  available  in  a  variety  of  shapes  and  sizes  to  accommodate  specific  approach, 
pathology and anatomical requirements of the patient and the particular fusion procedure. Our implants are designed for insertion into 
the smallest possible space while maximizing surface area contact for fusion. Our fixation products, including pedicle screws, rods 
and plates, have been uniquely designed and include a highly differentiated percutaneous minimally invasive solution with advanced 
guide technology, superior rod insertion options, and multiple reduction capabilities to be delivered through our procedures to provide 
stabilization of the spine.  Our fixation offerings include our Precept and ReLine posterior fixation portfolios.  

6 

 
 
Nerve Monitoring 

Our  nerve  monitoring  systems  utilize  electromyography,  or  EMG,  as  well  as  proprietary  software  hunting  algorithms  and 
graphical  user  interfaces  to  provide  surgeons  with  an  enhanced  and  intuitive  nerve  avoidance  system.  Our  systems  function  by 
monitoring  changes  in  electrical  signals  across  muscle  groups,  which  allows  us  to  detect  underlying  changes  in  nerve  activity. 
Through the NVM5 platform, we give surgeons the option to connect their instruments to a computer system that provides discrete, 
real-time, surgeon directed and surgeon controlled feedback about the directionality and relative proximity of nerves during surgery. 
Our systems analyze and then translate complex neurophysiologic data into simple, useful information to assist the surgeon’s clinical 
decision-making  process.  The  health  and  integrity  of  the  spinal  cord  and  related  nerves  can  also  be  assessed  using  motor  evoked 
potentials, or MEPs, and somatosensory evoked potentials, SSEPs. Both of these methods of IOM involve applying stimulation and 
recording the response that must travel along the motor or sensory paths of the spinal cord.  Surgeons can connect certain instruments 
to  our  nerve  monitoring  systems,  thus  creating  an  interactive  set  of  instruments  that  better  enable  the  safe  navigation  through  the 
body’s  nerve  anatomy  during  surgery.  The  connection  is  accomplished  using  a  clip  that  is  attached  to  the  instrument,  effectively 
providing  the  benefits  of  our  nerve  monitoring  systems  through  an  instrument  already  familiar  to  the  surgeon.  The  system’s 
proprietary software and easy to use graphical user interface allows the surgeon to make critical decisions in real time enabling safer, 
faster, and more reproducible procedures with the design for improved patient outcomes.   

In  addition  to  our  MAS  platform,  our  comprehensive  procedural  solution  includes  our  biologics  products,  IOM  services,  and 

iGA technology. 

Biologics 

Biologics  are used  to  aid  in the  spinal  fusion  process or bone healing process.    The global biologics market  in  spine  surgery 
consists of autograft (autologous human tissue), allograft (donated human tissue), a varied offering of synthetic products, stem cell-
based  products,  and  growth  factors.  We  currently  offer  Formagraft,  a  collagen-based  synthetic  bone  substitute,  AttraX,  a  synthetic 
bone graft material delivered in putty form, Propel DBM, a highly moldable demineralized bone matrix putty, and Osteocel Plus and 
Osteocel Pro, an allograft cellular matrix designed to mimic the biologic profile of autograft that includes mesenchymal stem cells and 
osteoprogenitors to aid in fusion. 

Intraoperative Monitoring Services 

Monitoring  the  health  of  the  nervous  system  during  spinal  surgery  has  been  a  key  component  of  our  strategy  of  product 
differentiation since early in our development. Over time, surgeon and hospital demand for nerve monitoring has increased along with 
the advancement of technologies and techniques used in IOM. We believe that our proprietary NVM5 platform is a differentiator in 
the  market  and  is  unique  in  its  ability  to  provide  information  about  the  directionality  and  proximity  of  nerves.    Through  our  IOM 
services  business,  we  provide  onsite  and  remote  monitoring  of  the  neurological  systems  of  patients  undergoing  spinal  and  brain-
related  surgeries.    Our  neurophysiologists  are  present  in  the  operating  room  during  procedures  and  work  in  partnership  with 
supervising  physicians  who  remotely  oversee  and  interpret  neurophysiological  data  gathered  via  broadband  transmission  over  the 
Internet.  Through  this  service,  data  can  be  analyzed  in  real  time  by  healthcare  professionals  for  additional  interpretation  of 
intraoperative  information  and  oversight,  which  we  believe  further  improves  the  safety  and  reproducibility  of  the  vast  array  of  our 
spine procedures. 

Integrated Global Alignment 

Current and emerging data illustrates a direct correlation between proper spinal alignment and long-term clinical outcomes.  Our 
iGA  platform  offers  a  global  approach  for  assessing,  preserving,  and  restoring  spinal  alignment  in  an  effort  to  promote  surgical 
effectiveness  and  efficiencies,  lasting  patient  outcomes,  and  improved  quality  of  life.    Using  our  NuvaPlanning  portfolio  of  three 
software  solutions,  NuvaMap,  NuvaLine  and  NuvaMap  O.R.,  surgeons  can  preoperatively  calculate  and  evaluate  alignment 
parameters and implant integration by accurately modeling surgery to create a reliable plan with clear results, and then conduct a real-
time interoperative assessment in order to correct the anterior and posterior column alignment in line with the surgical plan. Following 
a  procedure,  surgeons  can  use our  solutions  to  confirm  the success of  the procedure  and  effect  on  alignment  by  reviewing  surgical 
results and easily comparing those results to the surgical plan.  In addition to our software solutions, we also offer specific products 
that are designed to restore alignment, including our ReLine posterior fixation portfolio and our Bendini spinal rod bending system.   

Following  our  acquisition  of  Ellipse  Technologies  in  February  2016,  we  now  offer  products  that  leverage  the  MAGEC  and 
PRECICE technology to treat the unmet clinical needs of children who suffer from early onset scoliosis and patients who suffer from 
limb length discrepancies. 

7 

 
 
MAGEC-EOS Spinal Bracing and Distraction System 

Early  onset  scoliosis,  or  EOS,  refers  to  severely  deformed  curvatures  of  the  spine diagnosed  before  the  age  of  ten.  EOS  is  a 
challenging health issue and can lead to more severe progressive deformities. Surgical treatments for early onset scoliosis include the 
use of surgically adjustable expandable rods to control the spine deformity while still allowing the spine to grow until a child reaches 
an appropriate size or age for a more permanent solution, such as spinal fusion. Surgeries to adjust spinal rods are highly invasive and 
associated with significant scarring, long recovery times, high infection rates, post-operative pain and impaired mobility as the child 
heals from surgery. Surgical adjustments to traditional growing rods are typically made every six to nine months to accommodate the 
growth of the spine.  The MAGEC-EOS system is designed to overcome the limitations of conventional adjustable rod treatments for 
EOS. By enabling non-invasive adjustments, we believe MAGEC-EOS results in lower rates of complications associated with surgical 
procedures and repetitive exposure to general anesthesia. Our non-invasive adjustment technology enables physicians to perform more 
frequent adjustments in an outpatient setting, thereby improving deformity correction and allowing for optimal spinal growth.  

PRECICE Limb Lengthening System 

Limb length discrepancies, or LLDs, refer to a congenital deformity or injury resulting in one leg being shorter than the other. 
Large  LLDs  often  require  complex  treatments  including  limb  lengthening  surgery  to  create  equal  limb  length.  The  traditional  limb 
lengthening  surgical  procedure  includes  the  creation  of  a  gap  in  the  bone,  or  osteotomy,  the  attachment  of  wires  or  pins  to  the 
fractured bones, and the passing of the wires or pins through the skin to an external fixator, a scaffold-like frame that surrounds the 
limb.  The  external  fixator  distracts  the  bone  when  the  patient  or  a  family  member  manually  turns  the  knobs  on  the  fixator.  These 
adjustments  must  be  performed  several  times  each  day  such  that  the  bone  is  lengthened  approximately  one  millimeter  per  day. 
Adjustments  of  the  external  fixator  are  very  painful  and  associated  with  soft  tissue  disruption,  disturbance  of  the  wound  healing 
process  of  the  skin  and  soft  tissue  and  high  rates  of  infection.  In  addition,  traditional  external  fixation  can  result  in  significant 
psychosocial comorbidities that reduce quality of life for patients undergoing treatment, including anxiety, social disengagement, sleep 
disorders,  depression  and  addiction  to  pain  medication.  The  PRECICE  LLD  system  uses  the  MAGEC  technology  to  enable  non-
invasive and painless adjustments using a pre-programmed ERC. As a result, PRECICE LLD enables physicians to customize therapy 
to the needs of the patient over time without the need for surgical re-intervention and provides improved quality of life and satisfaction 
for patients in need of surgical limb lengthening.  

In  addition,  we  intend  to  continue  development  on  a  wide  variety  of  projects  intended  to  broaden  surgical  applications  for 
greater  procedural  integration  of  our  MAS  techniques  and  additional  applications  of  the  MAGEC  technology.  Such  applications 
include  tumor,  trauma,  and  deformity,  as  well  as  increased  fixation  options  and  sagittal  alignment  products.  We  also  expect  to 
continue expanding our other product and services offerings as we execute on our strategy to offer our customers a procedural solution 
for spine surgery that distinguishes us from traditional spine implant companies.   

Research and Development  

Our research and development efforts are primarily focused on developing further enhancements to our existing products and 
improving  and  further  integrating  our  procedural  solutions  to  address  unmet  clinical  needs  while  improving  patient  and  economic 
outcomes. Our research and development group has extensive experience in developing products to treat spine pathologies and this 
group continues to work closely with our clinical advisors and spine surgeon customers to design products and procedural solutions 
designed  to  improve  patient  outcomes,  simplify  techniques,  and  reduce  patient  trauma  and  the  subsequent  hospitalization  and 
rehabilitation times, and - as a result - reduce overall costs to patients and the healthcare system.  

International  

We  believe  a  spine  market  shift  towards  minimally  invasive  surgery  and  increases  in  international  access  to  healthcare  will 
provide  us with  an  opportunity  for  accelerated growth  outside  the United States.  Because  our procedurally-integrated solutions and 
technologies treat similar pathologies around the world, we are focused on expanding our operations in select developed and emerging 
international  markets.  We  are  investing  to  tailor  our  products  and  technologies  to  meet  varying  international  patient,  surgeon  and 
market  requirements.  We  are  also  investing  in  expanding  our  global  infrastructure  to  adapt  to  alternative  distribution  channels,  to 
support  differing  language  and  customer  service  requirements,  and  to  provide  training  and  surgeon  education  in  our  MAS  surgical 
techniques, our complementary instruments and our implants to our international customers. During 2015, we expanded many offices 
across the world as part of our focus on increasing our commercial footprint outside the United States. We have continued to expand 
our  available  product  offerings  internationally  and  accelerated  our  international  product  offerings  with  our  acquisition  of  Ellipse 
Technologies in February 2016. Our geographic expansion efforts  will enable us to accelerate our global market share position and 
change patient’s lives, not just in the United States, but around the world. Our international revenue, which excludes Puerto Rico, was 
$96.3 million or 12% of total revenue for the year ended December 31, 2015. 

8 

 
 
Sales and Marketing  

In  the  United  States,  we  currently  sell  our  procedurally-integrated  solutions  through  a  combination  of  exclusive  independent 
sales  agents  and  directly-employed  sales force.  Each  member  of  our United States sales  force  is responsible  for  a defined  territory, 
with  our  independent  sales  agents  acting  as  our  sole  representative  in  their  respective  territories.  The  determination  of  whether  to 
engage a directly-employed sales representative or an independent sales agent is made on a territory–by-territory basis, with a focus on 
aligning the sales team with the best skills and experience with local surgeons’ needs. Our international sales force is comprised of 
directly-employed  sales  representatives,  as  well  as  exclusive  distributors  and  independent  sales  agents.  The  split  between  directly-
employed sales force and independent sales agents and distributors in our sales force is approximately equal. 

Surgeon Training and Education  

We devote significant resources to training and educating surgeons regarding the safety and reproducibility of our MAS surgical 
techniques  and  our  complementary  instruments  and  implants.  We  maintain  state-of-the-art  cadaver  operating  rooms  and  training 
facilities to help educate surgeons regarding our products at our corporate headquarters in San Diego, California. We continue to train 
surgeons on the XLIF technique and our other MAS platform products including: our proprietary nerve monitoring systems, MaXcess, 
biologics, and specialized implants. The number of surgeons trained annually includes first-time surgeons new to our MAS product 
platform as well as surgeons previously trained on our MAS product platform who are attending advanced training programs.  

Manufacturing and Supply  

We rely  on  third  parties for  the  manufacture  of  a  majority  of our products,  their  components  and servicing,  and we  maintain 
alternative manufacturing sources for a majority of our finished goods products. We also manufacture certain implants internally at 
our  facility  in  Dayton,  Ohio.  We  have  identified  or  are  in  the  process  of  identifying  and  qualifying  additional  suppliers,  on  a  per 
product  basis,  for  our  highest  volume  products  to  best  enable  us  to  be  able  to  maintain  consistent  supply  to  our  customers.  Our 
outsourcing  strategy  is  targeted  at  companies  that  meet  FDA,  International  Organization  for  Standardization  (ISO),  and  quality 
standards  supported  by  internal  policies  and  procedures.  Supplier  performance  is  maintained  and  managed  through  a  supplier 
qualification, performance management and corrective action program intended to ensure that all of our product requirements are met 
or  exceeded.  We  believe  that  these  types  of  manufacturing  relationships  historically  have  balanced  our  capital  investment,  helped 
control costs and provided manufacturing capacity necessary to compete with larger volume manufacturers of spine surgery products. 
As our business has continued to scale, we have determined to increase the amount of products that we self-manufacture. In 2015 we 
added an approximately 179,000 square foot manufacturing facility in Dayton, Ohio, and announced our plans to build out and equip 
the new facility in order to expand our internal manufacturing efforts. As we shift to the manufacturing of more of our products in 
house, we will look to ensure adequate raw materials suppliers, sourcing alternatives and adequate supply to support our operations. 

 Our products are inspected, packaged and labeled, as needed, at either our San Diego headquarters or our Memphis distribution 
facility. Under our existing contracts with third-party manufacturers, we reserve the exclusive right to inspect and assure conformance 
of each product and product component to our specifications.  

We currently rely on several tissue banks as our suppliers of allograft tissue implants, including two for our Osteocel Plus and 
Osteocel Pro product lines. Like our relationships with our device manufacturing suppliers, we subject our tissue processing suppliers 
to the same quality criteria in terms of selection, qualification, and verification of processed tissue quality upon receipt of goods, as 
well as hold them accountable to compliance with FDA regulations, state requirements, and as-voluntary industry standards (such as 
those put forward by the American Association of Tissue Banks).  

We rely on one, exclusive supplier for PEEK, which comprises our CoRoent partial vertebral body replacement and interbody 
product lines. We also rely on one, exclusive supplier for our NVM5 neuromonitoring system, and rely on one, exclusive supplier for 
our neuromonitoring equipment that is used outside of the NV platform.  

We, and our third-party manufacturers, are subject to the quality system regulations of the U.S. Food and Drug Administration 
(FDA),  state  regulations  (such  as  the  regulations  promulgated  by  the  California  Department  of  Health  Services),  and  regulations 
promulgated by foreign regulatory bodies (such as in the European Union). For tissue products, we are FDA registered and licensed in 
the States of California, New York, Florida, Maryland and Oregon. For our device implants and instruments, we are FDA registered, 
California licensed, CE marked and ISO certified. CE is an abbreviation for “Conformité Européenne” or European Conformity, and 
is  the  registration  marking  designating  that  a  device  can  be  commercially  distributed  throughout  Europe.  Our  facilities  and  the 
facilities of our third-party manufacturers are subject to periodic announced and unannounced inspections by regulatory authorities, 
and may undergo compliance inspections conducted by the FDA, state, and/or international regulatory agencies.  

Surgical Instrument and Implant Sets  

For many of our customers, we provide surgical instrumentation sets, including both implants and instruments, as well as our 
nerve monitoring systems in a manner tailored to fulfill our customer’s obligations to meet surgery schedules. We do not generally 
receive  separate  economic  value  specific  to  the  surgical  instrument  sets  from  the  surgeons  or  hospitals  that  utilize  them.  In  many 
cases, once the surgery is finished, the surgical instrument sets are returned to us, and we prepare them for shipment to meet future 
surgeries.  

9 

 
 
We  complement  this  implant  and  instrument  shipment  model  with  field-based  instrument  assets.  This  hybrid  strategy  is 
designed to improve customer service, minimize backlogs, increase asset turns, optimize freight costs, and maximize cash flow. Our 
pool of surgical equipment that we loan to or place with hospitals continues to increase as we increase our product offering, expand 
our  distribution  channels  and  increase  the  market  penetration  of  our  products.  These  surgical  instrumentation  and  implant  sets  are 
important to the growth of our business, and we anticipate additional investments in such assets going forward.  

In certain cases we will sell either surgical instruments, implant sets or both to our customers. While this does not constitute a 
material  component  of  our  business,  as  customer  penetration  and  volume  increases,  these  sales  of  sets  allows  our  customers  to 
increase the amount of surgical volume performed locally.  

Intellectual Property  

We  rely  on  a  combination  of  patent,  trademark,  copyright,  trade  secret  and  other  intellectual  property  laws,  nondisclosure 
agreements and other measures to protect our intellectual property rights. We believe that in order to have a competitive advantage, we 
must develop and maintain the proprietary aspects of our technologies. We require our employees (who we refer to as “shareowners”), 
consultants  and  advisors  to  execute  confidentiality  agreements  in  connection  with  their  employment,  consulting  or  advisory 
relationships with us. We also require our shareowners, consultants and advisors who we expect to work on our products to agree to 
disclose and assign to us all inventions conceived using our property or which relate to our business. Despite any measures taken to 
protect our intellectual property, unauthorized parties may attempt to copy aspects of our products or to obtain and use information 
that we regard as proprietary.  

Patents  

As of December 31, 2015, we had over 350 issued and pending patents, including over 250 U.S. issued patents. Our issued and 

pending patents cover, among other things: 

•  MAS surgical access instrumentation and methodology, including our XLIF procedure and aspects thereof;  
•  Neurophysiology  enabled  instrumentation  and  methodology,  including  pedicle  screw  test  systems,  software  hunting 

algorithms, navigated guidance, rod bending and surgical access systems;  

•  Implants and related instrumentation and targeting systems;  
•  Biologics, including Osteocel Plus and Osteocel Pro, Formagraft and AttraX; and  
•  Motion preservation products.  

Our issued patents begin to expire in 2018. We do not believe that the expiration of any single patent is likely to significantly 

affect our intellectual property position.  

The  medical  device  industry  is  characterized  by  the  existence  of  a  large  number  of  patents  and  frequent  litigation  based  on 
allegations of patent infringement. Patent litigation can involve complex factual and legal questions and its outcome is uncertain. Our 
success will depend in part on our not infringing patents issued to others, including our competitors and potential competitors. As the 
number of entrants into our market increases, the possibility of future patent infringement claims against us grows. While we make 
extensive efforts to ensure that our products do not infringe other parties’ patents and proprietary rights, our products and methods 
may be covered by patents held by our competitors. There are numerous risks associated with our intellectual property. For a complete 
discussion of these risks, please see the “Risk Factors” section of this Annual Report.  

Trademarks  

As of December 31, 2015, we had over 200 trademark registrations in both domestic and foreign regions.  

Competition  

Competition  within  the  industry  is  primarily  based  on  technology,  innovation,  quality,  reputation  and  customer  service.  We 
believe that our significant competitors are Medtronic Sofamor Danek, or Medtronic, DePuy/Synthes, a Johnson & Johnson company, 
Stryker  Spine,  Globus  Medical,  Biomet  Spine,  and  Zimmer  Spine,  which  together  represent  a  significant  portion  of  the  spine 
market. We also face competition from a significant number of smaller companies with more limited product offerings and geographic 
reach  than  our  larger  competitors.  These  companies,  who  represent  intense  competition  in  specific  markets,  include  Orthofix 
International N.V., Alphatec Spine, Landauer, K2M and others. With respect to our nerve monitoring systems and IOM services, we 
compete with Medtronic, Biotronic NeuroNetwork, and VIASYS Healthcare, a division of Becton, Dickinson and Company. We also 
face competition from physician owned distributorships, or PODs, which are medical device distributors that are owned, directly or 
indirectly, by physicians. However, these PODs have recently come under scrutiny by the Office of Inspector General, or OIG as the 
associated physicians derive a portion of their revenue from selling or arranging for the sale of medical devices for use in procedures 
they perform on their own patients. The prevalence of these PODs may impact our ability to grow. 

10 

 
 
The United States Government Regulation  

Our products are medical devices and human tissue products subject to extensive regulation by the FDA and other regulatory 
bodies both inside and outside of the United States. Each of these agencies requires us - to varying degrees - to comply with laws and 
regulations governing the development, testing, manufacturing, storage, labeling, marketing and distribution of our products.  

FDA’s Premarket Clearance and Approval Requirements  

Unless  an  exemption  applies,  each  medical  device  that  we  market  and  sell  in  the  United  States  must  first  receive  either 
premarket clearance (by submitting a 510(k) notification) or premarket approval (by filing a premarket approval application, or PMA) 
from the FDA. In addition, certain modifications to marketed devices may require 510(k) clearance or approval of a PMA supplement. 
The FDA’s 510(k) clearance process usually takes between three and six months from the date the application is completed, but may 
last longer. The process of obtaining PMA approval is much more costly, lengthy and uncertain than the 510(k) clearance process and 
generally takes between one and three years, or even longer, from the time the application is submitted to the FDA until any approval 
is  obtained.  In  addition,  a  clinical  trial  is  almost  always  required  to  support  a  PMA  application  and  may  be  required  for  a  510(k) 
premarket  notification.  There  are  numerous  risks  associated  with  conducting  clinical  trials,  including  high  costs  and  uncertain 
outcomes. For a complete discussion of these risks, please see the “Risk Factors” section of this Annual Report.  

Human Cell, Tissue, and Cellular and Tissue Based Products  

Our allograft products, including our Triad, H2 and ExtenSure, and our Osteocel Plus and Osteocel Pro products, are regulated 
by  the  FDA  as  Human  Cell,  Tissue,  and  Cellular  and  Tissue  Based  Products.  FDA  regulations  do  not  currently  require  these 
minimally  manipulated  human  tissue-based  products  to  be  subjected  to  a  premarket  approval    or  pre-market  notification  process 
before they are marketed if they are deemed to meet the requirements of a “361” product under the Public Health Safety Act.  

We are, however, required to register with the FDA as a provider of such products and to list these products with the FDA and 
comply with its Current Good Tissue Practices for Human Cell, Tissue, and Cellular- and Tissue-Based Product Establishments. The 
FDA  periodically  inspects  tissue  facilities  to  determine  compliance  with  these  requirements.  Entities  that  provide  us  with  allograft 
bone  tissue  are  responsible  for  performing  donor  recovery,  donor  screening,  donor  testing,  processing,  and  packaging  and  our 
compliance with those aspects of the Current Good Tissue Practices regulations that regulate those functions are dependent upon the 
actions of these independent entities.  

The  procurement  and  transplantation  of  allograft  bone  tissue  is  subject  to  United  States federal  law  pursuant  to  the  National 
Organ Transplant Act (NOTA), a criminal statute that prohibits the purchase and sale of human organs used in human transplantation - 
including bone and related tissue - for “valuable consideration” (as defined in the NOTA). The NOTA permits reasonable payments 
associated with the removal, transportation, processing, preservation, quality control, implantation and storage of human bone tissue. 
With the exception of removal and implantation, we provide services, directly or indirectly, in all of these areas. We make payments 
to vendors in consideration for the services they provide in connection with the recovery and screening of donors. Failure to comply 
with the requirements of NOTA could result in enforcement action against us.  

The procurement of human tissue is also subject to state anatomical gift acts and some states have statutes similar to NOTA. In 
addition,  some  states  require  that  tissue  processors  be  licensed  by  that  state.  Failure  to  comply  with  state  laws  could  also  result  in 
enforcement action against us.  

Continuing FDA Regulation  

After  a  device  is  placed  on  the  market,  numerous  regulatory  requirements  continue  to  apply.  These  regulatory  requirements 

include, but are not limited to, the following:  

•  product listing and establishment registration;  
•  adherence to the Quality System Regulation which requires stringent design, testing, control, documentation and other quality 

assurance procedures;  

•  labeling requirements and FDA prohibitions against the promotion of off-label uses or indications;  
•  adverse event reporting;  
•  post-approval restrictions or conditions, including post-approval clinical trials or other required testing;  
•  post-market surveillance requirements;  
•  the FDA’s recall authority, whereby it can ask for, or require, the recall of products from the market; and  
•  requirements relating to voluntary corrections or removals.  

Failure to comply with applicable regulatory requirements can result in fines and other enforcement actions by the FDA, which 

could adversely impact our business.  

11 

 
 
We are also subject to announced and unannounced inspections by the FDA, the California Food and Drug Branch, American 
Association of Tissue Banking, as well as other regulatory agencies overseeing the implementation and adherence of applicable state 
and federal device and tissue licensing regulations. These inspections may include our manufacturing and subcontractors’ facilities.  

Pursuant to FDA regulations, we can only market our products for cleared or approved uses. Although surgeons are permitted to 
use  medical  devices  for  indications  other  than  those  cleared  or  approved  by  the  FDA  based  on  their  medical  judgment,  we  are 
prohibited from promoting products for such “off-label” uses.  

Healthcare Regulation and Commercial Compliance  

The healthcare industry is highly regulated and changes in laws and regulations can be significant. The federal government and 
all states in which we currently operate regulate various aspects of our business.  Changes in the law or new interpretation of existing 
laws  can  have  a  material  effect  on  our  permissible  activities,  the  relative  costs  associated  with  doing  business  and  the  amount  of 
reimbursement by government and other third-party payers.   

Anti-kickback Statute 

We  are  subject  to  the  federal  anti-kickback  statute  which,  among  other  things,  prohibits  the  knowing  and  willful  solicitation, 
offer, payment or receipt of any remuneration, direct or indirect, in cash or in kind, in return for, or to induce the referral of patients 
for, items or services covered by Medicare, Medicaid and certain other governmental health programs. Under the Patient Protection 
and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act of 2010 (PPACA), neither knowledge of 
the anti-kickback statute nor the specific intent to violate the law is a requirement for being found in violation of such laws. Violation 
of  the  anti-kickback  statute  may  result  in  civil  or  criminal  penalties  and  exclusion  from  Medicare,  Medicaid  and  other  federal 
healthcare programs,  and  -  according  to  PPACA  - now  provides  a basis for  liability  under  the  False Claims  Act.  Many  states  have 
enacted similar statutes, which are not limited to items and services paid for under Medicare or a federally funded healthcare program. 
We believe that our operations materially comply with the anti-kickback statutes; however, because these provisions are interpreted 
broadly  by  regulatory  authorities,  we  cannot  be  assured  that  law  enforcement  officials  or  others  will  not  challenge  our  operations 
under these statutes.  

Federal False Claims Act 

The Federal False Claims Act (in particular -its “qui tam” or “whistleblower” provisions) allow(s) private individuals to bring 
actions in the name of the United States government alleging that a defendant has made false claims for payment from federal funds. 
In addition, various states are considering enacting or have enacted laws modeled after the Federal False Claims Act, penalizing false 
claims against state funds. In 2013, we received a federal administrative subpoena from the OIG in connection with an investigation 
into possible false or otherwise improper claims submitted to Medicare and Medicaid. The subpoena sought discovery of documents 
for  the  period  January  2007  through  April  2013.  In  July  2015,  we  entered  into  a  definitive  settlement  agreement  with  the  U.S. 
Department of Justice, or DOJ, to settle this matter. Under the terms of the agreement, we agreed to pay $13.5 million plus fees and 
accrued interest of approximately $0.3 million to resolve this matter. The settlement was not an admission of liability or wrongdoing 
by us, and we were not required to enter into a corporate integrity agreement with the OIG as part of the settlement. On August 31, 
2015, we received a civil investigative demand, or CID, issued by the DOJ pursuant to the federal False Claims Act. The CID requires 
the  delivery  of  a  wide  range  of  documents  and  information  related  to  an  investigation  by  the  DOJ  concerning  allegations  that  we 
assisted a physician group customer in submitting improper claims for reimbursement and made improper payments to the physician 
group  in  violation  of  the  Anti-Kickback  Statute.  We  are  cooperating  with  the  DOJ  in  regards  to  this  matter.  Any  adverse  findings 
related to this investigation could result in material financial penalties against the Company. 

Health Insurance Portability and Accountability Act 

Under  the  Health  Insurance  Portability  and  Accountability  Act  of  1996,  as  was  amended  in  2005  and  in  2009,  or  HIPAA,  a 
Covered  Entity,  as  further  defined  under  HIPAA,  is  required  to  adhere  to  certain  requirements  regarding  the  use,  disclosure  and 
security  of protected  health  information,  or  PHI.  In  the past,  HIPAA  has  generally  affected  us  indirectly,  as  NuVasive  is  generally 
neither a Covered Entity nor a Business Associate, as further defined under HIPAA, to Covered Entities, except that our provision of 
IOM  services  through  various  subsidiaries  may  create  a  Business  Associate  relationship;  additionally,  we  treat  our  Puerto  Rico 
subsidiary  as  a  Covered  Entity.  Regardless  of  Covered  Entity  status  under  HIPAA,  in  those  cases  where  patient  data  is  received, 
NuVasive is committed to maintaining the security and privacy of PHI. The potential for enforcement action against us is now greater, 
as the U.S. Department of Health and Human Services (HHS) can take action directly against Business Associates. Thus, while we 
believe we are and will be in compliance with all required HIPAA standards, there is no guarantee that the government will agree. 
Enforcement actions can be costly and interrupt regular operations of our business.  

12 

 
 
Foreign Corrupt Practices Act 

The  United  States  and  foreign  government  regulators  have  increased  regulation,  enforcement,  inspections  and  governmental 
investigations of the medical device industry, including increased United States government oversight and enforcement of the Foreign 
Corrupt Practices Act. If the United States or another foreign governmental authority were to conclude that we are not in compliance 
with applicable laws or regulations, such governmental authority can impose fines, delay or suspend regulatory clearances, institute 
proceedings  to  detain  or  seize  our  products,  issue  a  recall,  impose  operating  restrictions,  enjoin  future  violations  and  assess  civil 
penalties against us or our officers or employees, and can recommend criminal prosecution to the Department of Justice. Moreover, 
governmental  authorities  can  ban  or  request  the  recall,  repair,  replacement  or  refund  of  the  cost  of  any  device  or  product  we 
manufacture or distribute. We are also potentially subject to the UK Bribery Act, which would also subject us to the imposition of 
civil  and  criminal  fines.  Any  of  the  foregoing  actions  could  result  in  decreased  sales  as  a  result  of  negative  publicity  and  product 
liability claims, and could have a material adverse effect on our financial condition, results of operations and prospects.  

Physician Payments Sunshine Act of 2009 (Sunshine Act) 

The Sunshine Act was enacted into law in 2010 and requires public disclosure to the United States government of payments to 
physicians and teaching hospitals, including in-kind transfers of value such as free gifts or meals. The Act also provides penalties for 
non-compliance. The Sunshine Act requires that we file an annual report on March 31st of a calendar year for the transfers of value 
incurred  for  the  prior  calendar  year.  This  law,  along  with  individual  state  reporting  requirements,  such  as  in  Massachusetts  and 
Vermont, increases the possibility that a healthcare company may run afoul of one or more of the requirements.  

Compliance Program: 

A  compliance  program  is  a  set  of  internal  controls  established  by  a  company  to  prevent  and/or  detect  any  non-compliant 
activities  and  to  address  properly  those  issues  that  may  be  discovered.  The  United  States  government  has  recommended  that 
healthcare companies, among others, develop and maintain an effective compliance program to reduce the likelihood of any such non-
compliance  by  the  company,  its  employees,  agents  and  contractors.  In addition,  some  states,  such  as  Massachusetts  and  California, 
now require certain healthcare companies to have a formal compliance program in place in order to do business within the state. For 
years,  we  have  maintained  a  compliance  program  structured  to  meet  the  requirements  of  the  federal  sentencing  guidelines  for  an 
effective  compliance  program  and  the  model  compliance  program  guidance  promulgated  by  HHS  over  the  years.  Our  program 
includes, but  is  not  limited  to,  a  Code  of Ethical  Business  Conduct, designation of  a compliance  officer,  oversight  by  a  designated 
committee of our Board of Directors, policies and procedures, a confidential disclosure method (a hotline), and conducting periodic 
audits to ensure compliance.  

Foreign Government Regulation  

Sales of medical devices outside the United States are subject to foreign government regulations, which vary substantially from 
country to country. The time required to obtain approval by a foreign country may be longer or shorter than that required for FDA 
approval, and the requirements may differ.  

The European Union has adopted numerous directives and standards regulating the design, manufacture, clinical trials, labeling, 
and adverse event reporting for medical devices. Additionally, certain countries (such as Switzerland), have voluntarily adopted laws 
and regulations that mirror those of the European Union with respect to medical devices. Devices that comply with the requirements 
of a relevant directive will be entitled to bear “CE” conformity marking, and, accordingly, can be commercially distributed throughout 
Europe. The method  of  assessing  conformity  varies depending on  the  class of  the product,  but normally  involves  a  combination  of 
self-assessment  by  the  manufacturer  and  a  third-party  assessment  by  a  “Notified  Body”.  This  third-party  assessment  consists  of  an 
audit  of  the  manufacturer’s  quality  system  and  technical  review  of  the  manufacturer’s  product.  We  have  now  successfully  passed 
several Notified  Body  audits  since  our original  certification  in 2001, granting us ISO  certification  and  allowing  the  CE  conformity 
marking to be applied to certain of our devices under the European Union Medical Device Directive.  

The Japanese government in recent years made revisions to the Pharmaceutical Affairs Law (now called PMD Act) that made 
significant  changes  to  the  preapproval regulatory  systems.  These  changes  have  -  in  part  -  stipulated  that,  in  addition  to obtaining a 
manufacturing  or  import  approval  from  the  Ministry  of  Health,  Labor  and  Welfare,  certain  low-risk  medical  devices  can  now  be 
evaluated  by  third-party  organizations.  Based  on  the  risk-based  classification,  manufacturers  are  provided  three  procedures  for 
satisfying  the  PMD  Act  requirements  prior  to  placing  products  on  the  market:  Pre-market  Submission,  or  Todokede;  Pre-market 
Certification,  or  Ninsho;  and  Pre-market  Approval,  or  Shonin.  NuVasive  markets  devices  in  Japan  that  are  assessed  by  both 
government entities and third-party organizations using all three procedures in place for manufacturers. The level of review and time 
line  for  medical  device  approval  will  depend  on  the  risk-based  classification  and  subsequent  regulatory  procedure  that  the  medical 
device  is  aligned  based  on  assessment  against  the  current  PMD  Law.  Manufacturers  must  also  obtain  a  manufacturing  or  import 
license from the prefectural government prior to importing medical devices. We also pursue authorizations required by the prefectural 
government as required.  

13 

 
 
Device and tissue premarket approval and/or registration and/or facility licensing requirements also exist in other markets where 
international NuVasive facilities are established and/or where we may conduct business, including, but not limited to, Southeast Asia, 
Australia, and Latin America.  Such requirements vary by country and NuVasive has established procedures to drive its compliance 
with these requirements. 

Third-Party Reimbursement  

Broadly speaking, payer pushback on spine surgery in the United States has increased in the recent past, and we believe this has 

had an overall dampening effect on spine procedure volumes and prices.  

We expect that sales volumes and prices of our products and services will continue to be largely dependent on the availability of 
reimbursement  from  third-party  payers,  such  as  governmental  programs,  for  example,  Medicare  and  Medicaid,  private  insurance 
plans,  accountable  care  organizations  and  managed  care  programs.  Reimbursement  is  contingent  on  established  coding  for  a  given 
procedure, coverage of the codes by the third-party payers, and adequate payment for the resources used.  

Physician  coding  for  procedures  is  established  by  the  American  Medical  Association,  or  AMA.  For  coding  related  to  spine 
surgery,  the  North  American  Spine  Society,  or  NASS,  is  the  primary  liaison  to  the  AMA.  In  July  of  2006,  NASS  established  the 
proper  physician  coding  for  the  XLIF  procedure  by  declaring  it  to  be  encompassed  in  existing  codes  that  describe  an  anterolateral 
approach to the spine. This position was confirmed in a formal statement by NASS in January 2010. Hospital coding is established by 
CMS. XLIF is included in the nomenclature for hospital codes as an additional descriptor under long standing codes. All physician 
and hospital coding is subject to change which could impact reimbursement and physician practice behavior.  

Independent of the coding status, third-party payers may deny coverage based on their own criteria, including if they feel that a 
device or procedure is not well established clinically, is not the most cost-effective treatment available, or is used for an unapproved 
indication.  At  various  times  in  the  past,  certain  insurance  providers  have  adopted  policies  of  not  providing  reimbursement  for  the 
XLIF procedure. We have worked with our surgeon customers and NASS who, in turn, have worked with these insurance providers to 
supply  the  information,  explanation  and  clinical  data  they  require  to  categorize  the  XLIF  procedure  as  a  procedure  entitled  to 
reimbursement under their policies. At present, the majority of insurance companies provide reimbursement for XLIF procedures.  

However,  certain  carriers,  large  and  small,  may  have  policies  significantly  limiting  coverage  of  XLIF,  Interlaminar  Lumbar 
Interbody  Fusion,  or  ILIF,  Osteocel  Plus  and  Osteocel  Pro,  the  PCM  motion-preserving  Cervical  Disc  System,  cervical  interbody 
implants,  and/or  other  procedures,  products  or  services  that  we  offer.  We  will  continue  to  provide  resources  to  patients,  surgeons, 
hospitals, and insurers in order to ensure optimum patient care and clarity regarding reimbursement and work to remove any and all 
non-coverage policies. National and regional coverage policy decisions are subject to unforeseeable change and have the potential to 
impact  physician  behavior  and  reimbursement  for  physician  services.  We  cannot  offer  definitive  time  frames  or  final  outcomes 
regarding reversal of the coverage-limiting policies, as the process is dictated by the third-party insurance providers. For a discussion 
of these risks, please see the “Risk Factors” section of this Annual Report. 

Payment amounts are established by government and private payer programs and are subject to fluctuations which could impact 
physician practice behavior. Third-party payers are increasingly challenging the prices charged for a wide range of medical products 
and services, including those in spine and intraoperative monitoring where we participate.  

In international markets, reimbursement and healthcare payment systems vary significantly by country and many countries have 
instituted price ceilings on specific product lines. There can be no assurance that our products will be accepted by third-party payers, 
that reimbursement will be available, and/or that the third-party payers’ reimbursement policies (if available) will not adversely affect 
our ability to sell our products profitably.  

Particularly in the United States where major healthcare reform provisions are scheduled, third-party payers must demonstrate 
they  can  improve  quality  and  reduce  costs;  we  accordingly  see  an  increase  in  pre-approval/prior  authorizations  and  non-coverage 
policies citing higher levels of evidence required for medical  therapies and technologies. In addition, insured individuals are facing 
increased  premiums  and  higher  out–of-pocket  costs  for  medical  coverage  which  can  lead  a  patient  to  delay  medical  treatment.  An 
increasing number of insured individuals receive their medical care through managed care programs, which monitor and often require 
pre-approval of the services that a member will receive. The percentage of individuals covered by managed care programs is expected 
to grow in the United States over the next decade. 

We believe that the overall escalating cost of medical products and services has led to, and will continue to lead to, increased 
pressures  on  the  healthcare  industry  to  reduce  the  costs  of  products  and  services.  There  can  be  no  assurance  that  third-party 
reimbursement and coverage will be available or adequate, or that future legislation, regulation, or reimbursement policies of third-
party payers will not adversely affect the demand for our products and services or our ability to sell these products and services on a 
profitable basis. The unavailability or inadequacy of third-party payer coverage or reimbursement could have a material adverse effect 
on our business, operating results and financial condition. For a discussion of these risks, please see the “Risk Factors” section of this 
Annual Report.  

14 

 
 
Shareowners (our employees)  

We refer to our employees as “shareowners”. As of December 31, 2015, we had approximately 1,600 shareowners. In addition 
to our shareowners, we partner with exclusive independent sales agencies and independent distributors who sell our products in the 
United  States  and  internationally.  As  of  December  31,  2015,  there  are  approximately  450  individuals  associated  with  such  sales 
agencies  and  distributors.  None  of  our  shareowners  are  represented  by  a  labor  union,  and  we  believe  our  shareowner  relations  are 
good.  

 Corporate Information  

Our business was incorporated in Delaware in July 1997. Our principal executive offices are located at 7475 Lusk Boulevard, 

San Diego, California 92121, and our telephone number is (858) 909-1800. Our website is located at www.nuvasive.com.  

We  file  our  annual  reports  on  Form 10-K,  quarterly  reports  on  Form 10-Q  and  current  reports  on  Form 8-K,  and  any 
amendments to those reports, electronically with the Securities and Exchange Commission (the Commission). We make these reports 
available free of charge on our website under the investor relations page as soon as reasonably practicable after we electronically file 
such material with, or furnish it to, the Commission. All such reports were made available in this fashion during 2015.  

The public can also obtain any documents that we file with the Commission at http://www.sec.gov. The public may read and 
copy any materials that we file with the Commission at the Commission’s Public Reference Room at 100 F Street, N.E., Room 1580, 
Washington,  D.C.  20549.  The  public  may  obtain  information  on  the  operation  of  the  Public  Reference  Room  by  calling  the 
Commission at 1-800-SEC-0330. 

This report may refer to brand names, trademarks, service marks or trade names of other companies and organizations, and these 

brand names, trademarks, service marks and trade names are the property of their respective holders.  

Item 1A. 

Risk Factors 

An investment in our common stock involves a high degree of risk. Risk factors that could cause actual results to differ from our 
expectations and that could negatively impact our financial condition and results of operations are set forth below and elsewhere in 
this report. If any of these risks actually occur, our business, financial condition, results of operations and future growth prospects 
could be materially and adversely affected. Under these circumstances, the trading price of our common stock could decline, and you 
may lose all or part of your investment. Further, additional risks not currently known to us or that we currently believe are immaterial 
also may impair our business, operations, liquidity and stock price materially and adversely. You should consider carefully the risks 
and uncertainties described below and elsewhere in this report before you decide to invest in our common stock. 

Risks Related to Our Business and Industry 

To be commercially successful, we must effectively demonstrate to spine surgeons the value proposition of our products and 

procedural solutions compared to those of our competitors. 

We  focus  on  marketing  our  products  and  procedural  solutions  to  spine  surgeons,  because  of  the  role  that  they  play  in 
determining the course of patient treatment. We believe spine surgeons will not widely adopt our products and procedural solutions 
unless  we  are  able  to  effectively  educate  and  train  them  as  to  the  distinctive  characteristics,  perceived  benefits,  safety  and  cost-
effectiveness of our offerings as compared to those of our competitors. Surgeons may be hesitant to use our products and procedural 
solutions for the following reasons, among others: 

•  lack of surgeon experience with minimally-disruptive surgical products and procedures; 
•  lack or perceived lack of evidence supporting additional patient benefits; 
•  perceived liability risks generally associated with the use of new products and procedures; 
•  existing relationships with competitors and distributors; 
•  limited or lack of availability of coverage and reimbursement within healthcare payment systems; 
•  increased competition in lateral procedural offerings; 
•  lack or perceived lack of differentiation among lateral procedures; 
•  costs associated with the purchase of new products and equipment; and 
•  the time commitment that may be required for training. 

15 

 
 
 
If we are not able to effectively demonstrate to spine surgeons the value proposition of our products and procedural solutions, or 
if spine surgeons adopt competing products into their practice, our sales could significantly decrease or fail to increase, which could 
adversely impact our profitability and cash flow. In addition, we believe recommendations and support of our offerings by influential 
spine surgeons and other key opinion leaders are essential for market acceptance and adoption. If we are not successful in obtaining 
such support, surgeons may not use our products and procedural solutions, and we may not achieve expected sales or profitability. 

Our  future  success  depends  on  our  strategy  of  obsoleting  our  products  and  our  ability  to  timely  acquire,  develop  and 

introduce new products or product enhancements that will be accepted by the market. 

An important part of our business strategy is to stay ahead of our competitors by obsoleting our current offerings with new and 
enhanced products and technologies.  As such, our success will depend in part on our ability to acquire, develop and introduce new 
products  and  enhancements  to  our  existing  products  to  keep  pace  with  changes  in  technology  and  market  demand,  as  well  as 
physician, hospital and healthcare provider practices.  The success of any new product offering or enhancement to an existing product 
will depend on numerous factors, including our ability to: 

•  properly identify and anticipate surgeon and patient needs; 
•  develop and introduce new products or product enhancements in a timely and cost-effective manner; 
•  adequately protect our intellectual property and avoid infringing upon the intellectual property rights of third parties; 
•  demonstrate the safety and efficacy of new products through the conduct of clinical investigations or the collection of existing 

relevant clinical data; and 

•  obtain the necessary regulatory clearances or approvals for new products or product enhancements. 

In  addition,  our  research  and  development  efforts  may  require  a  substantial  investment  of  time  and  resources  before  we  are 
adequately  able  to  determine  the  commercial  viability  of  a  new  product,  technology,  or  other  innovation.    Even  if  we  are  able  to 
develop  enhancements  or  new  generation  products  successfully,  these  enhancements  or  new  generation  products  may  not  generate 
sufficient demand or produce sales in excess of the costs of development, which would cause our results of operations to suffer.  It is 
also important that we carefully manage our introduction of new and enhanced products. If potential customers delay purchases until 
new or enhanced products are available, it could negatively impact our sales.  In addition, to the extent we have excess or obsolete 
inventory  as  we  transition  to  new  products,  it  would  result  in  margin  reducing  write-offs  for  obsolete  inventory,  and  our  results  of 
operations may suffer. 

We  operate  in  a  highly  competitive  market  segment  that  is  subject  to  rapid  change,  and  if  we  are  unable  to  compete 

successfully, our sales and operating results may suffer.   

The market for spine surgery products and procedures is intensely competitive, subject to rapid change and significantly affected 
by new product introductions and other market activities of industry participants. Our ability to compete successfully will depend on 
our ability to develop proprietary products that reach the market in a timely manner, receive adequate reimbursement and are safer, 
less invasive and less expensive than those of our competitors. With respect to our nerve monitoring systems and IOM services, we 
compete with Medtronic and VIASYS Healthcare, a division of Becton, Dickinson and Company, each of which have significantly 
greater  resources  than  we  do,  as  well  as  numerous  regional  nerve  monitoring  companies,  such  as  Biotronic  NeuroNetwork.  With 
respect to MaXcess, our minimally-disruptive surgical system, our largest competitors are Medtronic, DePuy/Synthes, Stryker Spine, 
Globus  Medical,  and  Zimmer  Spine.  We  compete  with  many  of  the  same  companies  with  respect  to  our  other  products.  We  also 
compete with numerous smaller companies with respect to our implant products, many of whom have a significant regional market 
presence. At any time, these companies and other potential market entrants may develop alternative treatments, products or procedures 
for  the  treatment  of  spine  disorders  that  compete  directly  or  indirectly  with  our  offerings.    In  addition,  they  may  gain  a  market 
advantage by developing and patenting competitive products or processes earlier than we can or by obtaining regulatory clearances or 
market registrations more rapidly than we can.  

Many of our competitors have greater resources than we have. 

Many of our larger competitors are either publicly traded or divisions or subsidiaries of publicly traded companies, and enjoy 

several competitive advantages over us, including: 

•  significantly greater name recognition; 
•  established relationships with a greater number of spine surgeons, hospitals, other healthcare providers and third-party payers; 
•  larger and more well-established distribution networks domestically and/or internationally; 
•  products supported by long-term clinical data; 
•  greater experience in obtaining and maintaining FDA and other regulatory approvals or clearances for products and product 

enhancements; 

16 

 
 
•  more expansive portfolios of intellectual property rights; and 
•  greater financial assets, cash flow, capital markets access and other resources for product research and development, sales and 

marketing, and litigation. 

Because  of  the  significant  size  of  the  potential  market  for  spine  surgery  products  and  procedures,  we  anticipate  that  existing 
competitors will continue to dedicate significant resources to developing competing products.  If we are unable to compete effectively, 
our sales and operating results may suffer. 

Changes to third-party reimbursement policies and practices, including non-coverage decisions, can negatively impact our 

ability to sell our products and services. 

Sales of our products and procedural solutions depend on the availability of adequate reimbursement from third-party payers. 
We believe  that  future  third-party reimbursement  for health  care  costs may  be  subject  to  changes  in  policies  and practices,  such as 
more  restrictive  criteria  to  qualify  for  surgery  coverage  or  reduction  in  payment  amounts  to  hospitals  and  surgeons  for  approved 
surgery and IOM services, both in the United States and internationally.  Further, certain third-party payers have stated non-coverage 
decisions  concerning  our  technologies  and  services.    These  actions  could  significantly  alter  our  ability  to  sell  our  products  and 
procedural solutions.  The continuing efforts of governmental authorities, insurance companies, and other payers of health care costs 
to contain or reduce costs could lead to patients being unable to obtain approval for payment from these third-party payers. Changes in 
legislation, regulation or reimbursement policies of third-party payers may adversely affect the demand for our products and services 
as healthcare providers generally rely on third-party payers to reimburse all or part of the costs and fees associated with the procedures 
performed  with  these  devices  and  services.  Likewise,  spine  surgeons,  neurophysiologists  and  their  supervising  physicians  rely 
primarily on third-party reimbursement for the surgical or monitoring fees they earn. Spine surgeons are unlikely to use our products 
and services if they do not receive reimbursement adequate to cover the cost of their involvement in surgical procedures.   

Pricing pressure from our competitors, hospital customers and insurance providers can negatively impact our ability to sell 

our products and services. 

The  market  for  spine  surgery  products  is  large  and  has  attracted  numerous  new  companies  and  technologies.    As  some 
companies  have  sought  to  compete  based  on  price,  it  has  created  pricing  pressure,  which  we  expect  to  continue  in  the  future.    In 
addition,  we  may  experience  decreasing  prices  for  our  products  due  to  pricing  pressure  from  our  hospital  customers  and  insurance 
providers.  Because healthcare costs have risen significantly over the past decade, numerous initiatives and reforms have resulted in 
efforts to drive down prices.  As hospitals look to reduce costs, including by aggregating purchasing decisions and through industry 
consolidation, they may demand lower pricing and limit their number of suppliers.  If competitive forces drive down the prices, we are 
able to charge for our products, our profit margins will shrink, which will adversely affect our ability to maintain our profitability and 
to invest in and grow our business.   

The proliferation of physician-owned distributorships, as well as aggressive competitive tactics to attract away key customers, 

could result in increased pricing pressure and harm our ability to maintain or grow revenue. 

Physician-owned distributorships, or PODs, are medical device distributors that are owned, directly or indirectly, by physicians.  
These  physicians  derive  revenue  from  selling  or  arranging  for  the  sale  of  medical  devices  via  their  PODs  that  are  used  in  the 
procedures they perform on their patients.  We do not sell or distribute any of our products to PODs.  However, the proliferation of 
PODs  may  reduce  our  market  opportunities  and  may  hamper  our  ability  to  grow  or  maintain  revenue.    PODs  can  have  significant 
market  knowledge  and  access  to  the  surgeons  who  use  our  products,  and  we  have  seen  increasingly  aggressive  competitive  tactics 
from  PODs  focused  on  attracting  customers  away  from  us.    To  the  extent  these  tactics  are  successful,  our  revenue  may  materially 
suffer. 

If the quality of our products does not meet the expectations of physicians or patients, then our brand and reputation could 

suffer and our business could be adversely impacted. 

In the course of conducting our business, we must adequately address quality issues that may arise with our products, as well as 
defects in third-party components included in our products.  Although we have established internal procedures to minimize risks that 
may arise from quality issues, we may not be able to eliminate or mitigate occurrences of these issues and associated liabilities.  If the 
quality of our products does not meet the expectations of physicians or patients, then our brand and reputation could suffer and our 
business could be adversely impacted. 

The safety of many of our products is not yet supported by long-term clinical data and many of our products may therefore 

prove to be less safe and effective than initially thought. 

As a consequence of our strategy to obsolete our own products with new technologies, many of our products do not have a long 
history  of  use.  Further,  many  of  our  products  are  subject  to  the  FDA’s  510(k)  premarket  notification  clearance  process,  which 
typically does not require clinical data.  Accordingly, many of our products currently lack the breadth of published long-term clinical 
data supporting their safety and effectiveness. For these reasons, spine surgeons may be slow to adopt our products, we may not have 
comparative data that our competitors have or are generating, and we may be subject to greater regulatory and product liability risks.  

17 

 
 
Further,  future  patient  studies  or  clinical  experience  may  indicate  that  treatment  with  our  products  does  not  improve  patient 
outcomes. Such results would reduce demand for our products, affect sustainable reimbursement from third-party payers, significantly 
reduce our ability to achieve expected revenue and could prevent us from sustaining or increasing profitability. Moreover, if future 
results and experience indicate that our products cause unexpected or serious complications or other unforeseen negative effects, we 
could  be  subject  to  significant  legal  liability  and  harm  to  our  business  reputation.  The  spine  medical  device  market  has  been 
particularly  prone  to potential  product  liability  claims  that  are  inherent  in  the  testing,  manufacture and sale  of  medical  devices  and 
products for spine surgery procedures. 

We  may  engage  in  strategic  transactions,  including  acquisitions,  investments,  or  joint  development  agreements  that  may 

have an adverse effect on our business.  

We may pursue transactions, including acquisitions of complementary businesses, technology licensing arrangements and joint 
development agreements to expand our product offerings and geographic presence as part of our business strategy, which could be 
material to our financial condition and results of operations. We may not complete transactions in a timely manner, on a cost-effective 
basis, or at all, and we may not realize the expected benefits of any acquisition, license arrangement or joint development agreement. 
Other companies may compete with us for these strategic opportunities. We also could experience negative effects on our results of 
operations  and  financial  condition  from  acquisition-related  charges,  amortization of  intangible  assets  and  asset  impairment  charges, 
and other issues that could arise in connection with, or as a result of, the acquisition of an acquired company or business, including 
issues related to internal control over financial reporting, regulatory or compliance issues and potential adverse short-term effects on 
results of operations through increased costs or otherwise.  

In  February 2016,  we  completed  the  acquisition  of  Ellipse  Technologies  for  an  upfront  payment  of  $380.0 million  and  a 
potential  milestone  payment  of  $30 million  payable  in  2017  related  to  the  achievement  of  specific  revenue  targets.  Acquisitions, 
including the acquisition of Ellipse Technologies, involve numerous risks, including the following: 

•  difficulties in finding suitable partners or acquisition candidates; 
•  difficulties in obtaining financing on favorable terms, if at all; 
•  difficulties in completing transactions on favorable terms, if at all; 
•  the  possibility  that  we  will  pay  more  than  the  value  we  derive  from  the  acquisition,  which  could  result  in  future  non-cash 

impairment charges and/or a dilution of future earnings per share; 

•  difficulties  in  integration  of  the  operations,  technologies,  personnel,  and  products  of  the  acquired  companies,  which  may 
require  significant  attention  of  the  Company’s  management  team  that  otherwise  would  be  available  for  the  ongoing 
development of our business; 

•  the  applicability  of  additional  laws,  regulations  and  policies  that  have  particular  application  to  our  acquisitions,  including 
those relating to patient privacy, insurance fraud and abuse, false claims, prohibitions against self-referrals, anti-kickbacks, 
direct billing practices, HIPAA compliance, and prohibitions against the corporate practice of medicine and fee-splitting; 

•  the assumption of certain known and unknown liabilities of the acquired companies; 
•  the incurrence of debt, contingent liabilities or future write-offs of intangible assets or goodwill; 
•  difficulties in retaining key relationships with employees, customers, partners and suppliers of the acquired company; and 
•  difficulties in operating in different business markets where we may not have historical experience. 

Any of these factors could have a negative impact on our business, results of operations or financial position. Further, past and 
potential acquisitions entail risks, uncertainties and potential disruptions to our business, especially where we have limited experience 
as a company developing or marketing a particular product or technology. In addition, we may face additional risks related to foreign 
acquisitions.  Foreign acquisitions involve unique risks in addition to those mentioned above, including those related to integration of 
operations across different cultures and languages, currency risks and the particular economic, political and regulatory risks associated 
with specific countries. 

Health  care  policy  changes,  including  United  States  health  care  reform  legislation  signed  in  2010,  may  have  a  material 

adverse effect on us. 

In March 2010, the Affordable Care Act was enacted in the United States, which made a number of substantial changes in the 

way healthcare is financed by both governmental and private insurers. Among other things, the Affordable Care Act: 

•  requires certain medical device manufacturers to pay a sales tax equal to 2.3% of the price for which such manufacturer sells 

its medical devices, provided that such tax, after going into effect in 2013, has now been suspended until 2018; 

18 

 
 
•  establishes  a  new  Patient-Centered  Outcomes  Research  Institute  to  oversee  and  identify  priorities  in  comparative  clinical 

effectiveness research in an effort to coordinate and develop such research; 

•  implements  payment  system  reforms  including  a  national  pilot  program  on  payment  bundling  to  encourage  hospitals, 
physicians  and  other  providers  to  improve  the  coordination,  quality  and  efficiency  of  certain  healthcare  services  through 
bundled payment models; and 

•  establishes  an  Independent  Payment  Advisory  Board  that  will  submit  recommendations  to  reduce  Medicare  spending  if 

projected Medicare spending exceeds a specified growth rate. 

In addition, other legislative changes have been proposed and adopted since the Affordable Care Act was enacted. On August 2, 
2011, the Budget Control Act of 2011 was signed into law, which, among other things, created the Joint Select Committee on Deficit 
Reduction to recommend to Congress proposals in spending reductions. The Joint Select Committee did not achieve a targeted deficit 
reduction  of  at  least  $1.2  trillion  for  the  years  2013  through  2021,  triggering  the  legislation’s  automatic  reduction  to  several 
government programs. This includes reductions to Medicare payments to providers of 2% per fiscal year, which went into effect on 
April  1,  2013  and,  due  to  subsequent  legislative  amendments  to  the  statute,  will  remain  in  effect  through  2024  unless  additional 
Congressional action is taken. On January 2, 2013, the American Taxpayer Relief Act of 2012 was signed into law, which, among 
other things, reduced Medicare payments to several providers, including hospitals, and increased the statute of limitations period for 
the government to recover overpayments to providers from three to five years. 

We expect that additional state and federal healthcare reform measures will be adopted in the future, any of which could limit 
the amounts that federal and state governments will pay for healthcare products and services, which could result in reduced demand 
for our products or additional pricing pressure. 

Our IOM business exposes us to risks inherent with the sale of services. 

Our IOM services business exposes us to different risks than our other products and technologies.  Through our IOM services 
business,  we  provide  onsite  and  remote  monitoring  of  the  neurological  systems  of  patients  undergoing  spinal  and  brain-related 
surgeries.    Our  neurophysiologists  are  present  in  the  operating  room  during  procedures  and  work  in  partnership  with  supervising 
physicians  who  remotely  oversee  and  interpret  neurophysiological  data  gathered  via  broadband  transmission  over  the  Internet.  
Providing  this  service  subjects  us  to  malpractice  exposure.    In  addition,  given  the  reliance  on  technology,  any  disruption  to  our 
neuromonitoring equipment or the Internet could harm our service operations and our reputation among our customers. Further, any 
disruption to our computer systems could adversely impact the performance of our neurophysiologists. 

In addition, IOM services are directly billed to Medicare and commercial payers, which brings with it additional risks associated 
with proper billing practice regulations, HIPAA compliance, corporate practice of medicine laws, and new collections risk associated 
with  third-party  payers.    Due  to  the  breadth  of  many  healthcare  laws  and  regulations,  our  IOM  business  could  also  be  subject  to 
healthcare  fraud  regulation  and  enforcement  by  both  the  federal  government  and  the  states  in  which  we  conduct  our  business, 
including under the Anti-Kickback Law, the federal false claims laws and state law equivalents.  If our operations are found to be in 
violation of any of the laws described above or any other governmental regulations that apply to us, we may be subject to penalties, 
including civil and criminal penalties, damages, fines and the curtailment or restructuring of our operations. Any penalties, damages, 
fines, curtailment or restructuring of our operations could adversely affect our ability to operate our business and our financial results.  

19 

 
 
Our  employee  shareowners,  consultants,  distributors  and  other  commercial  partners  may  engage  in  misconduct  or  other 

improper activities, including non-compliance with regulatory standards and requirements. 

We are exposed to the risk that our employee shareowners, consultants, distributors and other commercial partners may engage 
in  fraudulent  or  illegal  activity.  Misconduct  by  these  parties  could  include  intentional,  reckless  or  negligent  conduct  or  other 
unauthorized activities that violate the regulations of the FDA and non-U.S. regulators, including those laws requiring the reporting of 
true, complete and accurate information to such regulators, manufacturing standards, healthcare fraud and abuse laws and regulations 
in  the  United  States  and  abroad  or  laws  that  require  the  true,  complete  and  accurate  reporting  of  financial  information  or  data.  In 
particular, sales, marketing and business arrangements in the healthcare industry, including the sale of medical devices, are subject to 
extensive laws and regulations intended to prevent fraud, misconduct, kickbacks, self-dealing and other abusive practices. These laws 
and regulations may restrict or prohibit a wide range of pricing, discounting, marketing and promotion, sales commission, customer 
incentive programs and other business arrangements. It is not always possible to identify and deter misconduct by employees, sales 
agencies, distributors and other third parties, and the precautions we take to detect and prevent this activity may not be effective in 
controlling unknown or unmanaged risks or losses or in protecting us from governmental investigations or other actions or lawsuits 
stemming  from  a  failure  to  comply  with  these  laws  or  regulations.  If  any  such  actions  are  instituted  against  us  and  we  are  not 
successful  in  defending  ourselves  or  asserting  our  rights,  those  actions  could  result  in  the  imposition  of  significant  fines  or  other 
sanctions, including the imposition of civil, criminal and administrative penalties, damages, monetary fines, possible exclusion from 
participation in Medicare, Medicaid and other federal healthcare programs, contractual damages, reputational harm, diminished profits 
and  future  earnings  and  curtailment  of  operations,  any  of  which  could  adversely  affect  our  ability  to  operate  our  business  and  our 
results of operations. Whether or not we are successful in defending against such actions or investigations, we could incur substantial 
costs, including legal fees, and divert the attention of management in defending ourselves against any of these claims or investigations. 

Risks Related to our Commercial Operations and Plans for Future Growth 

If we are unable to maintain and expand our network of direct and independent sales representatives, we may not be able to 

generate anticipated sales. 

In the United States, we sell our products through a combination of exclusive independent sales agents and directly-employed 
sales personnel. Our international sales force is comprised of independent sales agents, directly-employed sales personnel, as well as 
exclusive distributors. We expect these sales representatives to develop long-lasting relationships with the spine surgeons they serve. 
If our sales representatives fail to adequately promote, market and sell our products, or fail to develop lasting relationships with spine 
surgeons, our sales could significantly decrease or fail to increase. Further, we may terminate sales representatives from time to time, 
which  could  subject  us  to  claims  and  lawsuits.  Asserting  or  defending  against  these  types  of  claims  and  lawsuits  may  result  in 
significant legal fees and expenses, and if we are unsuccessful, we could be liable for damages. 

We  face  significant  challenges  and  risks  in  managing  our  geographically  dispersed  distribution  network  and  retaining  the 
individuals  who  make  up  that  network.    In  the  past,  we  have  experienced  departures  of  sales  representatives,  which  have  had  a 
negative impact on our results. While our recent efforts to retain and attract sales representatives have shown positive results, if any 
additional sales representatives were to leave us, our sales could be adversely affected. If sales representatives were to depart and be 
retained by one  of  our  competitors,  we  may  be unable  to  prevent  them  from  helping  competitors  solicit  business from  our existing 
customers, which could further adversely affect our sales. Because of the intense competition for their services, we may be unable to 
recruit or retain sales representatives to work with us. Failure to hire or retain qualified sales representatives would prevent us from 
expanding our business and generating sales. 

We may be unable to manage our future growth effectively, which could make it difficult to execute our business strategy. 

We  intend  to  grow  our  business  operations  and  we  may  experience  periods  of  rapid  growth  and  expansion.  This  anticipated 
future  growth  could  create  a  strain  on  our  organizational,  administrative  and  operational  infrastructure,  including  manufacturing 
operations, quality control, technical support and customer service, sales force management and general and financial administration. 
We may not be able to maintain the quality of or delivery timelines of our products or satisfy customer demand as it grows. Our ability 
to manage our growth properly will require us to continue to improve our operational, financial and management controls, as well as 
our reporting systems and procedures. 

If  our  commercial  operations  and  sales  volume  grow,  we  will  need  to  continue  to  increase  our  workflow  capacity  for 
manufacturing,  customer  service,  billing  and  general  process  improvements  and  expand  our  internal  quality  assurance  program, 
among other things. We will also need to purchase additional equipment, some of which can take several months or more to procure, 
set up and validate, and increase our manufacturing, maintenance, software and computing capacity to meet increased demand. These 
increases in scale, expansion of personnel, purchase of equipment or process enhancements may not be successfully implemented. 

20 

 
 
Our reliance on a limited number of suppliers and manufacturers could limit our ability to meet demand for our products in 

a timely manner or within our budget. 

We rely on a limited number of third-party suppliers and manufacturers to supply and manufacture a majority of our products, 
and  we  may  not  be  able  to  find  replacements  or  immediately  transition  to  alternative  suppliers.    Many  of  our  key  products  are 
manufactured at single locations, with limited alternate facilities.  Further, for reasons of quality assurance or cost effectiveness, we 
purchase certain components and raw materials from sole suppliers. 

To be successful, we rely on our suppliers to provide us with products and components in substantial quantities, in compliance 
with regulatory requirements, in accordance with agreed upon specifications, at acceptable cost and on a timely basis. In the event we 
experience delays, shortages, or stoppages of supply with any supplier, we would be forced to locate a suitable alternative supplier 
which  could  take  significant  time  and  result  in  significant  expense.  In  addition,  our  anticipated  growth  could  strain  the  ability  of 
suppliers to deliver an increasingly large supply of products, materials and components. If we are required to transition to new third-
party  suppliers  for  certain  components of our products,  the  use  of  components or  materials  furnished  by  these  alternative  suppliers 
could require us to alter our operations.  Any such interruption or alteration could harm our reputation, business, financial condition 
and results of operations. In addition, if we are required to change the manufacturer of a critical component of our products, we will be 
required  to  verify  that  the  new  manufacturer  maintains  facilities,  procedures  and  operations  that  comply  with  our  quality  and 
applicable  regulatory  requirements,  which  could  further  impede  our  ability  to  manufacture  our  products  in  a  timely  manner. 
Transitioning  to  a  new  supplier  could  be  time-consuming  and  expensive,  may  result  in  interruptions  in  our  operations  and  product 
delivery, could affect the performance specifications of our products or could require that we modify the design of those systems. 

Performance issues, service interruptions or price increases by our shipping carriers could adversely affect our business and 

harm our reputation and ability to provide our services on a timely basis. 

Expedited, reliable  shipping  is  essential  to our  operations. We rely heavily  on providers of  transport  services  for reliable  and 
secure  point-to-point  transport  of  our  products  to  our  customers  and  for  tracking  of  these  shipments.  Should  a  carrier  encounter 
delivery performance issues such as loss, damage or destruction of any products, it could be costly to replace such products in a timely 
manner  and  such  occurrences  may  damage  our  reputation  and  lead  to  decreased  demand  for  our  products  and  increased  cost  and 
expense to our business. In addition, any significant increase in shipping rates could adversely affect our operating margins and results 
of  operations.  Similarly,  strikes,  severe  weather,  natural  disasters  or  other  service  interruptions  affecting  delivery  services  we  use 
would adversely affect our ability to process orders for our products on a timely basis. 

Manufacturing  risks  may  adversely  affect  our  ability  to  manufacture  products  and  could  reduce  our  gross  margins  and 

negatively affect our operating results. 

We currently manufacture a portion of our products at a spine implant manufacturer based in Dayton, Ohio that we acquired in 
May 2013, and in 2015 we added an approximately 179,000 square foot manufacturing facility in Dayton, Ohio and announced plans 
to  build  out  and  equip  the  new  facility  in  order  to  expand  our  internal  manufacturing  efforts.  As  part  of  our  business  strategy,  we 
intend to expand our ability to manufacture our current and new products with exceptional quality and in sufficient quantities to meet 
demand, while complying with regulatory requirements and managing manufacturing costs. We are subject to numerous risks relating 
to our manufacturing capabilities, including both those of our owned manufacturing facilities and those of our third party suppliers, 
such as: 

•  problems with quality control and assurance; 
•  defects in product components that we source from third-party suppliers; 
•  delays in obtaining components from third-party suppliers and component supply shortages; 
•  failing to predict demand accurately, resulting in a failure to increase production of products to meet demand; 
•  potential  adverse  effects  on  existing  business  relationships  with  current  third-party  suppliers  as  we  expand  our  in-house 

manufacturing capabilities; 

•  maintaining control over manufacturing expenses as production expands; 
•  difficulties associated with compliance with local, state, federal and foreign regulatory requirements; 
•  the inability to modify production lines to enable the efficient manufacture of new products or to quickly implement changes 

to current products in response to regulatory requirements; and 

•  potential damage to or destruction of our, or our suppliers’ manufacturing equipment or manufacturing facilities. 

21 

 
 
These risks may be exacerbated by our limited experience with in-house manufacturing processes and procedures. In addition, 
as we seek to expand our manufacturing capabilities, we will have to continue to invest additional resources to hire and train personnel 
and  enhance our production processes.  If we  fail  to  increase  our  manufacturing  capacity  efficiently,  our profit  margins  will  shrink, 
which will negatively affect our operating results. 

The loss of key employee shareowners, or our inability to recruit, hire and retain skilled and experienced personnel, could 

negatively impact our ability to effectively manage and expand our business. 

Our success depends on the skills, experience and performance of the members of our executive management team and other 
key employee shareowners. Their individual and collective efforts will be important as we continue to develop our products and as we 
expand  our  commercial  activities.  The  loss  or  incapacity  of  existing  members  of  our  executive  management  team  could  negatively 
impact  our  operations,  particularly  if  we  experience  difficulties  in  hiring  qualified  successors.  We  do  not  maintain  key  man  life 
insurance with respect to any of our employee shareowners. 

Our research and development programs and operations depend on our ability to attract and retain highly skilled engineers and 
technicians. We may not be able to attract or retain qualified managers, engineers and technicians in the future due to the competition 
for qualified personnel among medical device businesses, particularly in California. We also face competition from universities and 
public and private research institutions in recruiting and retaining highly qualified personnel. Recruiting and retention difficulties can 
limit our ability to support our commercial, manufacturing and research and development programs. All of our employee shareowners 
are employed on an at-will basis, which means that either we or the employee shareowner may terminate his or her employment at any 
time. The loss of key employee shareowners, the failure of any key employee shareowners to perform or our inability to attract and 
retain  skilled  employee  shareowners,  as  needed,  or  an  inability  to  effectively  plan  for  and  implement  a  succession  plan  for  key 
employee shareowners could harm our business. 

We face risks associated with our international business. 

During  the  year  ended  December  31,  2015,  approximately  12%  of  our  net  revenue  was  attributable  to  our  international 
customers.  We are seeking to increase our international sales over the foreseeable future. Our international business operations are 
subject to a variety of risks, including: 

•  difficulties in staffing and managing foreign and geographically dispersed operations; 
•  having to comply with various U.S. and international laws, including the U.S. Foreign Corrupt Practices Act of 1977, or the 

FCPA, and anti-money laundering laws; 

•  having  to  comply  with  export  control  laws,  including,  but  not  limited  to,  the  Export  Administration  Regulations  and  trade 
sanctions  against  embargoed  countries,  which  are  administered  by  the  Office  of  Foreign  Assets  Control  within  the 
Department of the Treasury, as well as the laws and regulations administered by the Department of Commerce; 

•  differing regulatory requirements for obtaining clearances or approvals to market our products; 
•  changes in, or uncertainties relating to, foreign rules and regulations that may impact our ability to sell our products, perform 

services or repatriate profits to the United States; 

•  tariffs and trade barriers, export regulations and other regulatory and contractual limitations on our ability to sell our products 

in certain foreign markets; 

•  fluctuations in foreign currency exchange rates; 
•  limitations on or increase of withholding and other taxes on remittances and other payments by foreign subsidiaries or joint 

ventures; 

•  differing multiple payer reimbursement regimes, government payers or patient self-pay systems; 
•  differing labor laws and standards; 
•  economic, political or social instability in foreign countries and regions; 
•  an inability, or reduced ability, to protect our intellectual property, including any effect of compulsory licensing imposed by 

government action; and 

•  availability of government subsidies or other incentives that benefit competitors in their local markets that are not available to 

us. 

22 

 
 
The FCPA  and  similar  anti-bribery  laws  in non-U.S. jurisdictions generally  prohibit  companies  and  their  intermediaries  from 
making  improper  payments  for  the  purpose  of  obtaining  or  retaining  business.  The  FCPA  also  imposes  accounting  standards  and 
requirements on publicly traded U.S. corporations and their foreign affiliates, which are intended to prevent the diversion of corporate 
funds  to  the  payment  of  bribes  and  other  improper  payments.  Because  of  the  predominance  of  government-sponsored  healthcare 
systems  around  the  world,  many  of  our  customer  relationships  outside  of  the  United  States  are  with  governmental  entities  and  are 
therefore subject to such anti-bribery laws. Our internal control policies and procedures may not always protect us from reckless or 
criminal  acts  committed  by  our  employee  shareowners,  distributors  or  agents.  In  recent  years,  both  the  United  States  and  foreign 
government  regulators  have  increased  regulation,  enforcement,  inspections  and  governmental  investigations  of  the  medical  device 
industry,  including  increased  United  States  government  oversight  and  enforcement  of  the  FCPA.  Despite  implementation  of  a 
comprehensive  global  healthcare  compliance  program,  we  may  be  subject  to  more  regulation,  enforcement,  inspections  and 
investigations by governmental authorities in the future.   

Any failure to comply with applicable legal and regulatory obligations in the United States or abroad could adversely affect us 
in a variety of ways that include, but are not limited to, significant criminal, civil and administrative penalties, including imprisonment 
of  individuals,  fines  and  penalties,  denial  of  export  privileges,  seizure  of  shipments  and  restrictions  on  certain  business  activities, 
disgorgement  and  other  remedial  measures,  disruptions  of  our  operations,  significant  management  distraction.  Also,  the  failure  to 
comply  with  applicable  legal  and  regulatory  obligations  could  result  in  the  disruption  of  our  distribution  and  sales  activities.  Any 
reduction in international sales, or our failure to further develop our international markets, could have a material adverse effect on our 
business, results of operations and financial condition. 

Our results may be impacted by changes in foreign currency exchange rates. 

As we increasingly compete in markets outside of the United States, we are and will be exposed to foreign currency exchange 
risk  related  to  our  foreign  operations.  A  significant  portion  of  our  foreign  subsidiaries’  operating  expenses  are  incurred  in  foreign 
currencies.  If the U.S. dollar weakens, our consolidated operating expenses would increase. An increase in the value of the U.S. dollar 
relative to foreign currencies could require us to reduce our selling price or risk making our products less competitive in international 
markets  or  our  costs  could  increase.  Also,  if  our  international  sales  increase,  we  may  enter  into  a  greater  number  of  transactions 
denominated in non-U.S. dollars, which could expose us to foreign currency risks, including changes in currency exchange rates. If we 
are unable to address these risks and challenges effectively, our international operations may not be successful and our business could 
be harmed. 

If we fail to properly manage our anticipated international growth, our business could suffer. 

We have invested, and expect to increase our investment for the foreseeable future, in our expansion into international markets. 

To execute our anticipated growth in international markets we must: 

•  manage the complexities associated with a larger, faster growing and more geographically diverse organization; 
•  expand  our  clinical  development  resources  to  manage  and  execute  increasingly  global,  larger  and  more  complex  clinical 

trials; 

•  manage our directly-employed sales personnel as well as distributors and independent sales agents operating in international 
markets often pursuant to laws, regulations and customs that may be different than those that are customary for our United 
States operations; 

•  expand our sales and marketing presence in international markets generally to avoid revenue concentration in a small number 
of  markets  that  would  subject  us  to  the  risk  of  business  disruption  as  a  result  of  economic  or  political  problems  in 
concentrated locations; 

•  upgrade  our  internal  business  processes  and  capabilities  (e.g.,  information  technology  platform  and  systems,  product 
distribution  and  tracking)  to  create  the  scalability  and  properly  handle  the  transaction  volumes  that  our  growing 
geographically diverse organization demands; and 

•  expend time and resources to receive product approvals and clearances to sell and promote products. 

We  expect  that  our  operating  expenses  will  continue  to  increase  as  we  continue  to  expand  into  international  markets. 
International markets  may  be  slower  than domestic  markets  in  adopting  our  products and  are  expected,  in  many  instances,  to  yield 
lower  profit  margins  when  compared  to  our  domestic  operations.  We  have  only  limited  experience  in  expanding  into  international 
markets as well as marketing and operating our products and services in such markets. 

23 

 
 
Additionally,  our  international  endeavors  may  involve  significant  risks  and  uncertainties,  including  distraction  of  Company 
management  from  domestic  operations,  insufficient  revenue  to  offset  the  expenses  associated  with  our  international  strategy,  and 
issues  not  discovered  in  our  due  diligence  of  new  markets  or  ventures.  Because  expansion  into  international  markets  is  inherently 
risky,  no  assurance  can  be  given  that  such  strategies  and  initiatives  will  be  successful  and  will  not  materially  adversely  affect  our 
financial condition and operating results. Even if our international expansion is successful, our expenses may increase at a greater pace 
than our revenue and our operating results could be harmed. 

Further,  our  anticipated  growth  internationally  will  place  additional  strain  on  our  suppliers  and  manufacturers,  resulting  in 
increased need for us to carefully monitor quality assurance. Any failure by us to manage our international growth effectively could 
have an adverse effect on our ability to achieve our development and commercialization goals. 

Cyber  security  risks  and  the  failure  to  maintain  the  confidentiality,  integrity,  and  availability  of  our  computer  hardware, 
software, and Internet applications and related tools and functions could result in harm to our business and/or subject us to costs, 
fines or lawsuits. 

We rely on sophisticated information technology systems and network infrastructure to operate and manage our business. We 
also maintain personally identifiable information (PII) about our employee shareowners, and given the nature of our business, we have 
access to PHI. Our business therefore depends on the continuous, effective, reliable, and secure operation of our computer hardware, 
software, networks, Internet servers, and related infrastructure. To the extent that our hardware or software malfunctions or access to 
our data by internal personnel, suppliers or customers through the Internet is interrupted or compromised, our business could suffer. 

The  integrity  and  protection  of  our  customer,  personnel,  financial,  research  and  development,  and  other  confidential  data  is 
critical  to  our  business  and  our  customers  and  employees  have  a  high  expectation  that  we  will  adequately  protect  their  personal 
information. The regulatory environment governing information, security and privacy laws is increasingly demanding and continues to 
evolve.  Although  our  computer  and  communications  hardware  is  protected  through  physical  and  software  safeguards,  it  is  still 
vulnerable  to  system  malfunction,  computer  viruses,  and  cyber-attacks.  These  events  could  lead  to  the  unauthorized  access  of  our 
information technology systems and result in the misappropriation or unauthorized disclosure of confidential information belonging to 
us,  our  employee  shareowners,  partners,  customers,  or  our  suppliers.  The  techniques  used  by  criminal  elements  to  attack  computer 
systems are sophisticated, change frequently and may originate from less regulated and remote areas of the world. As a result, we may 
not  be  able  to  address  these  techniques  proactively  or  implement  adequate  preventative  measures.  If  our  information  technology 
systems are compromised, we could be subject to fines, damages, litigation and enforcement actions and we could lose trade secrets or 
other confidential information, the occurrence of which could harm our business. 

Our operations are vulnerable to interruption or loss due to natural or other disasters, power loss, strikes and other events 

beyond our control.  

We conduct a significant portion of our activities, including administration and data processing, at facilities located in Southern 
California, an area that has experienced major earthquakes, fires and other natural disasters. A major earthquake, fire or other disaster 
(such as a major flood, tsunami, or terrorist attack) affecting our facilities, or those of our suppliers, could significantly disrupt our 
operations, and delay or prevent product shipment or installation during the time required to repair, rebuild or replace our facilities or 
those  of  our  suppliers.    These  delays  could  be  lengthy  and  costly.  If  any  of  our  customers’  facilities  are  negatively  impacted  by  a 
disaster, shipments of our products could be delayed. Additionally, customers may delay purchases of our products until operations 
return to normal. Even if we are able to quickly respond to a disaster, the ongoing effects of the disaster could create some uncertainty 
in the operations of our business. In addition, our facilities may be subject to a shortage of available electrical power and other energy 
supplies. Any shortages may increase our costs for power and energy supplies or could result in blackouts, which could disrupt the 
operations  of  our  affected  facilities  and  harm  our  business.  In  addition,  concerns  about  terrorism,  the  effects  of  a  terrorist  attack, 
political  turmoil  or  an  outbreak  of  epidemic  diseases  could  have  a  negative  effect  on  our  operations,  those  of  our  suppliers  and 
customers and the ability to travel, which could harm our business, financial condition and results of operations. 

Our insurance policies are expensive and protect us only from some business risks, which will leave us exposed to significant 

uninsured liabilities. 

We do not carry insurance for all categories of risk that our business may encounter. Some of the policies we currently maintain 
include  general  liability,  foreign  liability,  employee  benefits  liability,  property,  umbrella,  workers’  compensation,  products  liability 
and directors’ and officers’  insurance.   We  do not  know,  however,  if  we  will  be  able  to  maintain  existing  insurance  with  adequate 
levels of coverage. Any significant uninsured liability may require us to pay substantial amounts, which would adversely affect our 
cash position and results of operations. 

24 

 
 
We bear the risk of warranty claims on our products. 

We  bear  the  risk  of  express  and  implied  warranty  claims  on  products  we  supply,  including  equipment  and  component  parts 
manufactured by third parties. We may not be successful in claiming recovery under any warranty or indemnity provided to us by our 
suppliers or vendors in the event of a successful warranty claim against us by a customer or that any recovery from such vendor or 
supplier would be adequate. In addition, warranty claims brought by our customers related to third-party components may arise after 
our ability to bring corresponding warranty claims against such suppliers expire, which could result in additional costs to us. There is a 
risk  that  warranty  claims  made  against  us  will  exceed  our  warranty  reserve  and  our  business,  financial  condition  and  results  of 
operations could be harmed. 

Risks Related to Our Intellectual Property and Litigation 

We are currently involved in patent litigation involving Medtronic, and, if we do not prevail in the litigation and/or on our 
appeal of the Medtronic verdict in phase one of the litigation, we could be liable for substantial damages and might be prevented 
from making, using, selling, offering to sell, importing or exporting certain of our products. 

In August 2008, Medtronic filed suit against us in the U.S. District Court for the Southern District of California, alleging that 
certain of our products infringe, or contribute to the infringement of, U.S. patents owned by Medtronic. Trial in the first phase of the 
case began in August 2011, and in September 2011, a jury delivered an unfavorable verdict against us with respect to three Medtronic 
patents and a favorable verdict with respect to one of our patents. The jury awarded monetary damages of approximately $0.7 million 
to us which includes back royalty payments. Additionally, the jury awarded monetary damages of approximately $101.2 million to 
Medtronic  which  includes  lost  profits  and  back  royalties.  In  June  2013,  the  District  Court  determined  that  the  amount  of  ongoing 
royalties owed by us to Medtronic was 13.75% on certain of NuVasive’s CoRoent XL implants and 8.25% on certain of NuVasive’s 
MaXcess II and III retractors (the “June 2013 ruling”).  In August 2013, the parties filed their respective notices of appeal to the U.S. 
Court  of  Appeals  for  the  Federal  Circuit.  In  March  2015,  the  Court  of  Appeals  issued  a  decision  upholding  the  jury’s  findings  of 
liability  as  to  all  patents,  but  overturning  the  damage  award  against  us  as  improper  (“March  Court  of  Appeals  Decision”). 
Significantly,  the  Court  of  Appeals  held  that  the  damages  award  was  erroneous  because  Medtronic  was  not  permitted  to  recover 
damages for lost profits or for the sale of ancillary or “convoyed” products. Medtronic’s subsequent petition for rehearing was denied.  
The case has been remanded back to the District Court for further proceedings to determine a proper damage award, but a trial date 
has not been set. 

In August 2012, Medtronic filed additional patent claims against us alleging that several of our spinal implants (including our 
CoRoent XL family of spinal implants) and our Osteocel Plus bone graft product, along with the XLIF procedure, infringe Medtronic 
patents not asserted in prior phases of the case. We deny infringing any valid claims of these additional patents and in March 2013, we 
filed counterclaims against Medtronic asserting that Medtronic infringed eight Company patents. In July 2013, Medtronic amended its 
complaint to add a charge of infringement of another patent, U.S. Patent No. 8,444,696. The District Court has stayed the litigation as 
to a number of  patents asserted by both parties that are currently subject to reexamination or review proceedings conducted by the 
U.S. Patent Office. Both parties brought motions for summary judgment addressing the remaining patents, and Medtronic’s motion 
was granted, but the District Court has not yet issued a final decision regarding NuVasive’s motion. Currently, only one Medtronic 
patent remains in the case.  No trial date has been set in this third phase of the litigation. 

If  we  do  not  prevail  in  the  Medtronic  litigation  we  could  be  required  to  stop  selling  certain  of  our  products,  pay  substantial 
monetary  amounts  as  damages,  and/or  enter  into  expensive  royalty  or  licensing  arrangements.  Such  adverse  results  may  limit  our 
ability to generate profits and cash flow, and, as a consequence, to invest in and grow our business, including investments into new 
and innovative technologies. 

25 

 
 
We are currently, and may in the future be, subject to securities litigation, which is expensive and could divert management 

attention. 

In August 2013, a purported securities class action lawsuit was filed in the United States District Court for the Southern District 
of California naming us and certain of our current and former executive officers for allegedly making false and materially misleading 
statements regarding our business and financial results.  The lawsuit seeks unspecified monetary relief, interest, and attorneys’ fees. At 
December 31, 2015, the probable outcome of this litigation cannot be determined, nor can we estimate a range of potential loss. We 
may be the target of this type of litigation again in the future. Any securities litigation against us could result in substantial costs and 
divert management attention from other business concerns, which could seriously harm our business.   

We are currently, and may in the future be, subject to other claims and lawsuits that could cause us to incur significant legal 

expenses and result in harm to our business. 

We, as well as certain of our officers and sales representatives, are subject to claims or lawsuits from time to time. Regardless of 
the outcome, these lawsuits may result in significant legal fees and expenses and could divert management’s time and other resources. 
If the claims contained in these lawsuits are successfully asserted against us, we could be liable for damages and be required to alter or 
cease certain of our business practices or product lines. Any of these outcomes could cause our business, financial performance and 
cash position to be negatively impacted. Litigation may also harm our relationships with existing customers and subject us to negative 
publicity, each of which could harm our business and financial results. 

Our ability to protect our intellectual property and proprietary technology through patents and other means is uncertain. 

Our success depends significantly on our ability to protect our proprietary rights to the technologies used in our products and 
procedural  solutions.  We  rely  on  patent  protection,  as  well  as  a  combination  of  copyright,  trade  secret  and  trademark  laws,  and 
nondisclosure,  confidentiality  and  other  contractual  restrictions  to  protect  our  proprietary  technology.  However,  these  legal  means 
afford only limited protection and may not adequately protect our rights or permit us to gain or keep any competitive advantage. If we 
do not adequately protect our intellectual property and proprietary technology, competitors may be able to use our technologies and 
erode or negate any competitive advantage we may have, which could harm our business and ability to achieve profitability.  

Our pending U.S. and foreign patent applications may not issue as patents at all or not in a form that will be advantageous to us 
or may issue and be subsequently successfully challenged by others and invalidated. Our existing patents and any patents issued in the 
future may not have claims with a scope sufficient to protect our products, any additional features we develop for our products or any 
new products. Both the patent application process and the process of managing patent disputes can be time consuming and expensive. 
Other parties may have developed technologies that may be related or competitive to our technology, may have filed or may file patent 
applications and may have received or may receive patents that overlap or conflict with our patent applications, either by claiming the 
same methods or devices or by claiming subject matter that could dominate our patent position.  

If  we  seek  to  enforce  our  intellectual  property  rights  through  litigation  or  other  proceedings,  it  could  require  us  to  spend 

significant time and money, with uncertain results.  

In the event a competitor infringes upon our patent or other intellectual property rights, enforcing those rights may be costly, 
difficult and time consuming. We may not have sufficient resources to enforce our intellectual property rights or to defend our patents 
against a challenge. Our ability to enforce our patent rights depends on our ability to detect infringement. It may be difficult to detect 
infringers who do not advertise the components that are used in their products. Moreover, it may be difficult or impossible to obtain 
evidence  of  infringement  in  a  competitor’s  or  potential  competitor’s  product.  The  medical  device  industry  is  characterized  by  the 
existence of a large number of patents and frequent litigation based on allegations of patent infringement. It is not unusual for parties 
to  exchange  letters  surrounding  allegations of  intellectual  property  infringement  and  licensing  arrangements.  In  addition,  the patent 
positions of medical device companies, including our patent position, may involve complex legal and factual questions, and, therefore, 
the scope, validity and enforceability of any patent claims that we have or may obtain cannot be predicted with certainty.  

26 

 
 
Defending against litigation or other proceedings or third-party claims of intellectual property infringement could require us 
to  spend  significant  time  and  money,  and  if  we  are  unsuccessful,  we  may  be  obligated  to  pay  damages  and  halt  sales  of  our 
products.  

Our  commercial  success  depends  in  part  on  not  infringing  the  patents  or  violating  the  other  proprietary  rights  of  others.  
Significant litigation regarding patent rights occurs in our industry, and as we continue to commercialize our products in their current 
or updated forms, launch new products and enter new markets, we expect that competitors may claim that one or more of our products 
infringe their intellectual property rights as part of business strategies designed to impede our successful commercialization and entry 
into  new  markets.  A  patent  infringement  suit  brought  against  us  or  any  of  our  strategic  partners  or  licensees  may  force  us  or  such 
strategic partners or licensees to stop or delay developing, manufacturing or selling potential products that are claimed to infringe a 
third-party’s intellectual property, unless that party grants us or our strategic partners or licensees rights to use its intellectual property. 
In such cases, we may be required to obtain licenses to patents or proprietary rights of others in order to continue to commercialize our 
products.  However,  we  may  not  be  able  to  obtain  any  licenses  required  under  any  patents  or  proprietary  rights  of  third  parties  on 
acceptable terms, or at all, and any licenses may require substantial royalties or other payments by us. Even if our strategic partners, 
licensees or we were able to obtain rights to the third-party’s intellectual property, these rights may be non-exclusive, thereby giving 
our  competitors  access  to  the  same  intellectual  property.  Ultimately,  we  may  be  unable  to  commercialize  some  of  our  potential 
products or may have to cease some of our business operations as a result of patent infringement claims, which could severely harm 
our business. 

Moreover, we may become party to future adversarial proceedings regarding our patent portfolio or the patents of third parties. 
Such  proceedings  could  include  supplemental  examination  or  contested  post-grant  proceedings  such  as  inter  partes  review, 
reexamination,  interference  or  derivation  proceedings  before  the  U.S.  Patent  and  Trademark  Office  and  challenges  in  U.S.  District 
Court. Patents may be subjected to opposition, post-grant review or comparable proceedings lodged in various foreign, both national 
and regional, patent offices. The legal threshold for initiating litigation or contested proceedings may be low, so that even lawsuits or 
proceedings with a low probability of success might be initiated. Litigation and contested proceedings can also be expensive and time-
consuming, and our adversaries in these proceedings may have the ability to dedicate substantially greater resources to prosecuting 
these legal actions than we can.  

Any lawsuits resulting from such allegations could subject us to significant liability for damages and invalidate our proprietary 

rights. Any potential intellectual property litigation also could force us to do one or more of the following:  

•  stop making, selling or using products or technologies that allegedly infringe the asserted intellectual property;   
•  lose the opportunity to license our technology to others or to collect royalty payments based upon successful protection and 

assertion of our intellectual property rights against others;   

•  incur significant legal expenses;    
•  pay substantial damages or royalties to the party whose intellectual property rights we may be found to be infringing;   
•  pay the attorney’s fees and costs of litigation to the party whose intellectual property rights we may be found to be infringing;   
•  redesign  those  products  that contain  the  allegedly  infringing  intellectual  property,  which  could be  costly,  disruptive  and/or 

infeasible; or   

•  attempt to obtain a license to the relevant intellectual property from third parties, which may not be available on reasonable 

terms or at all.   

Any  litigation  or  claim  against  us,  even  those  without  merit,  may  cause  us  to  incur  substantial  costs,  and  could  place  a 
significant strain on our financial resources, divert the attention of management from our core business and harm our reputation. In 
addition,  we  generally  indemnify  our  customers  and  international  distributors  with  respect  to  infringement  by  our  products  of  the 
proprietary rights of third parties. If third parties assert infringement claims against our customers or distributors, we may be required 
to initiate or defend protracted and costly litigation on behalf of our customers or distributors, regardless of the merits of these claims. 
If  any  of  these  claims  succeed  or  settle,  we  may  be  forced  to  pay  damages  or  settlement  payments  on  behalf  of  our  customers  or 
distributors or may be required to obtain licenses for the products they use. If we cannot obtain all necessary licenses on commercially 
reasonable terms, our customers may be forced to stop using our products. 

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Recent changes in U.S. patent laws may limit our ability to obtain, defend and/or enforce our patents.  

Recent patent reform legislation could increase the uncertainties and costs surrounding the prosecution of our patent applications 
and  the  enforcement  or  defense  of  our  issued  patents.  The  Leahy-Smith  America  Invents  Act,  or  the  Leahy-Smith  Act,  includes  a 
number of significant changes to U.S. patent law. These include provisions that affect the way patent applications are prosecuted and 
also  affect  patent  litigation.  The  U.S.  Patent  and  Trademark  Office  recently  developed  new  regulations  and  procedures  to  govern 
administration of the Leahy-Smith Act, and many of the substantive changes to patent law associated with the Leahy-Smith Act, and 
in particular, the first to file provisions, which only became effective on March 16, 2013. The first to file provisions limit the rights of 
an inventor to patent an invention if not the first to file an application for patenting that invention, even if such invention was the first 
invention. Accordingly, it is not clear what, if any, impact the Leahy-Smith Act will have on the operation of our business. The pool of 
prior  art  available  to  inhibit  or  limit  our  ability  to  obtain  issued  patents  on  the  technology  utilized  in  our  products  is  expected  to 
expand and the grace period for filing a patent application has been reduced in some ways. It is now possible for a situation to arise in 
which a competitor is able to obtain patent rights to technology which we invented first. Furthermore, the newly enacted patent laws 
have expanded the types of post grant challenges of issued patents and these proceedings may provide our competitors with additional 
opportunities to challenge the validity of our issued patents. 

Additionally,  the  Leahy-Smith  Act  and  its  implementation  could  increase  the  uncertainties  and  costs  surrounding  the 
enforcement and defense of our issued patents. For example, the Leahy-Smith Act provides that an administrative tribunal known as 
the Patent Trial and Appeals Board, or PTAB, provides a venue for challenging the validity of patents at a cost that is much lower than 
district  court  litigation  and  on  timelines  that  are  much  faster.  Although  it  is  not  clear  what,  if  any,  long-term  impact  the  PTAB 
proceedings will have on the operation of our business, the initial results of patent challenge proceedings before the PTAB since its 
inception in 2013 have resulted in the invalidation of many U.S. patent claims. The availability of the PTAB as a lower-cost, faster 
and  potentially  more  potent  tribunal  for  challenging  patents  could  increase  the  likelihood  that  our  own  patents  will  be  challenged, 
thereby increasing the uncertainties and costs of maintaining and enforcing them. 

Further, competitors may challenge our issued patents through post-grant challenge procedures (domestically) and/or opposition 
proceedings (internationally). On March 16, 2012, the America Invents Act amended the post-grant challenge procedures in the U.S. 
to eliminate inter partes reexamination, maintain ex parte reexamination, and add inter partes review and supplemental examination. 
Both Medtronic and Globus filed inter partes reexamination requests (before March 16, 2012) against the patents we asserted against 
them.  Those  inter partes reexamination  requests were granted  and  those  proceedings  are  in progress.  Medtronic  filed  multiple  inter 
partes review petitions (after March 16, 2012) against the patents we asserted against them in phase 3. Those review petitions have not 
yet  been  finally  decided.  If  the  U.S.  Patent  Office  ultimately  cancels  or  narrows  the  claims  in  any  of  our  patents  through  these 
proceedings, it could prevent or hinder us from being able to enforce them against competitors. 

If we are unable to protect the confidentiality of our trade secrets, our business and competitive position could be harmed.  

In addition to patent protection, we also rely upon copyright and trade secret protection, as well as non-disclosure agreements 
and  invention assignment  agreements  with our  employee shareowners,  consultants and  third parties,  to protect  our  confidential  and 
proprietary information. In addition to contractual measures, we try to protect the confidential nature of our proprietary information 
using physical and technological security measures. Such measures may not, for example, in the case of misappropriation of a trade 
secret by an employee or third party with authorized access, provide adequate protection for our proprietary information. Our security 
measures may not prevent an employee or consultant from misappropriating our trade secrets and providing them to a competitor, and 
recourse we take against such misconduct may not provide an adequate remedy to protect our interests fully. Unauthorized parties may 
also attempt to copy or reverse engineer certain aspects of our products that we consider proprietary. Enforcing a claim that a party 
illegally disclosed or misappropriated a trade secret can be difficult, expensive and time-consuming, and the outcome is unpredictable. 
In addition, trade secrets may be independently developed by others in a manner that could prevent legal recourse by us. If any of our 
confidential or proprietary information, such as our trade secrets, were to be disclosed or misappropriated, or if any such information 
was independently developed by a competitor, our business and competitive position could be harmed. 

28 

 
 
We may not be able to enforce our intellectual property rights throughout the world.  

The laws of some foreign countries do not protect intellectual property rights to the same extent as the laws of the United States. 
Many  companies  have  encountered  significant  problems  in  protecting  and  defending  intellectual  property  rights  in  certain  foreign 
jurisdictions. This could make it difficult for us to stop infringement of our foreign patents, if obtained, or the misappropriation of our 
other intellectual property rights. For example, some foreign countries have compulsory licensing laws under which a patent owner 
must  grant  licenses  to  third  parties.  In  addition,  some  countries  limit  the  enforceability  of  patents  against  third  parties,  including 
government agencies or government contractors. In these countries, patents may provide limited or no benefit. Patent protection must 
ultimately  be  sought  on  a  country-by-country  basis,  which  is  an  expensive  and  time-consuming  process  with  uncertain  outcomes. 
Accordingly, we may choose not to seek patent protection in certain countries, and we will not have the benefit of patent protection in 
such countries.  

Proceedings  to  enforce  our  patent  rights  in  foreign  jurisdictions  could  result  in  substantial  costs  and  divert  our  efforts  and 
attention from other aspects of our business. Accordingly, our efforts to protect our intellectual property rights in such countries may 
be inadequate. In addition, changes in the law and legal decisions by courts in the United States and foreign countries may affect our 
ability to obtain adequate protection for our technology and the enforcement of our intellectual property. 

Third parties may assert ownership or commercial rights to inventions we develop.  

Third  parties may  in  the  future  make  claims  challenging  the  inventorship or ownership of our  intellectual  property.  We have 
written  agreements  with  collaborators  that  provide  for  the  ownership  of  intellectual  property  arising  from  our  collaborations.  In 
addition, we may face claims by third parties that our agreements with employee shareowners, contractors or consultants obligating 
them to assign intellectual property to us are ineffective or in conflict with prior or competing contractual obligations of assignment, 
which  could  result  in  ownership  disputes  regarding  intellectual  property  we  have  developed  or  will  develop  and  interfere  with  our 
ability to capture the commercial value of such intellectual property. Litigation may be necessary to resolve an ownership dispute, and 
if  we  are  not  successful,  we  may  be  precluded  from  using  certain  intellectual  property  or  may  lose  our  exclusive  rights  in  that 
intellectual property. Either outcome could harm our business and competitive position.  

Third  parties  may  assert  that  our  employees  or  consultants  have  wrongfully  used  or  disclosed  confidential  information  or 

misappropriated trade secrets.  

We  employ  individuals  who  previously  worked  with  other  companies,  including  our  competitors  or  potential  competitors. 
Although  we  try  to  ensure  that  our  employee  shareowners  and  consultants  do  not  use  the  proprietary  information  or  know-how  of 
others  in  their  work  for  us,  we  may  be  subject  to  claims  that  we  or  our  personnel,  consultants  or  independent  contractors  have 
inadvertently or otherwise used or disclosed intellectual property, including trade secrets or other proprietary information, of a former 
employer or other third party. Litigation may be necessary to defend against these claims. If we fail in defending any such claims or 
settling  those  claims,  in  addition  to  paying  monetary  damages  or  a  settlement  payment,  we  may  lose  valuable  intellectual  property 
rights or personnel. Even if we are successful in defending against such claims, litigation could result in substantial costs and/or be a 
distraction to management and other employee shareowners. 

If product liability lawsuits are brought against us, our business may be harmed, and we may be required to pay damages 

that exceed our insurance coverage.  

Our business exposes us to potential product liability claims  that are inherent in the testing, manufacture and sale of medical 
devices  for  spinal  surgery  procedures.  These  surgeries  involve  significant  risk  of  serious  complications,  including  bleeding,  nerve 
injury,  paralysis  and  even  death.  We  could  become  the  subject  of  product  liability  lawsuits  alleging  that  component  failures, 
malfunctions,  manufacturing  flaws,  design  defects  or  inadequate  disclosure  of  product-related  risks  or  product-related  information 
resulted in an unsafe condition or injury to patients.  

We have had, and continue to have, a small number of product liability claims relating to our products, none of which either 
individually,  or  in  the  aggregate,  have  resulted,  or  do  we  believe  will  result,  in  a  material  negative  impact  on  our  business.  In  the 
future,  we  may  be  subject  to  additional  product  liability  claims,  some  of  which  may  have  a  negative  impact  on  our  business. 
Regardless of the merit or eventual outcome, product liability claims may result in:  

•  decreased demand for our products;   
•  injury to our reputation;   
•  significant litigation costs;   
•  substantial monetary awards to or costly settlements with patients;   
•  product recalls;   
•  material defense costs;   
•  loss of revenue;   

29 

 
 
•  increased insurance costs; 
•  the inability to commercialize new products or product candidates; and   
•  diversion of management attention from pursuing our business strategy.   

Our  existing  product  liability  insurance  coverage  may  be  inadequate  to  protect  us  from  any  liabilities  we  might  incur.  If  a 
product liability claim or series of claims is brought against us for uninsured liabilities or in excess of our insurance coverage, our 
business could suffer. In addition, we may not be able to maintain insurance coverage at a reasonable cost or in sufficient amounts or 
scope to protect us against losses. Any claims against us, regardless of their merit, could severely harm our financial condition, strain 
our  management  and other  resources  and  adversely  affect or  eliminate  the prospects for  commercialization  or  sales of  a product or 
product candidate that is the subject of any such claim. 

Risks Related to our Legal and Regulatory Environment 

We are subject to rigorous FDA and other governmental regulations regarding the development, manufacture, and sale of 
our  products  and  we  may  incur  significant  expenses  to  comply  with  these  regulations  and  develop  products  that  satisfy  these 
regulations. 

The  medical  devices  we  manufacture  and  market  are  subject  to  rigorous  regulation  by  the  FDA  and  numerous  other  federal, 
state  and  foreign  governmental  authorities,  including  regulations  that  cover,  among  other  things,  the  composition,  labeling,  testing, 
clinical study, manufacturing, packaging, marketing and distribution of our products. 

We  are  required  to  register  with  the  FDA  as  a  device  manufacturer  and  tissue  bank.  As  a  result,  we  are  subject  to  periodic 
inspection by the FDA for compliance with the FDA’s Quality System Regulation (QSR) and Good Tissue Practices requirements, 
which require manufacturers of medical devices and tissue banks to adhere to certain regulations, including testing, quality control and 
documentation procedures. Our compliance with applicable regulatory requirements is subject to continual review and is rigorously 
monitored  through  periodic  inspections  by  the  FDA.  In  the  European  Community,  we  are  required  to  maintain  certain  ISO 
certifications  in  order  to  sell  our  products,  and  are  subject  to  periodic  inspections  by  Notified  Bodies  to  obtain  and  maintain  these 
certifications.  If  we  or  our  suppliers  fail  to  adhere  to  QSR,  ISO  or  other  applicable  regulations  and  standards,  it  could  negatively 
impact product production and regulatory clearances and could result in fines.  Further our products could be subject to recall by the 
FDA or other regulatory bodies, or voluntarily by us, in the event of a material deficiency or defect in design, manufacture, labeling of 
a  product  or  in  the  event  that  a  product  poses  an  unacceptable  risk  to  health.  These  and  other  consequences  could  have  a  material 
adverse effect on our sales and results of operations. 

Most medical devices must receive FDA clearance or approval before they can be commercially marketed. In addition, the FDA 
may require testing and surveillance programs to monitor the effects of approved products that have been commercialized, and can 
prevent  or  limit  further  marketing  of  a  product  based  upon  the  results  of  such  post-marketing  programs.  In  addition,  the  Federal 
Medical  Device  Reporting  Regulations  require  us  to  provide  information  to  the  FDA  whenever  there  is  evidence  that  reasonably 
suggests that a device may have caused or contributed to a death or serious injury or, if a malfunction were to occur, that could cause 
or  contribute  to  a  death  or  serious  injury.  Furthermore,  most  major  markets  for  medical  devices  outside  the  United  States  require 
clearance, approval or compliance with certain standards before a product can be commercially marketed. The process of obtaining 
regulatory  approvals  to  market  a  medical  device,  particularly  from  the  FDA  and  certain  foreign  governmental  authorities,  can  be 
costly and time-consuming, and approvals may not be granted for future products or product improvements on a timely basis, if at all. 
Delays in receipt of, or failure to obtain, approvals for future products or product improvements could result in delayed realization of 
product revenue or in substantial additional costs, which could have a material adverse effect on our business or results of operations 
or prospects. At any time after approval of a product, the FDA may conduct periodic inspections to determine compliance with both 
QSR requirements and/or current Medical Device Reporting regulations.  If we fail to comply with our reporting obligations, the FDA 
could take action, including warning letters, untitled letters, administrative actions, criminal prosecution, imposition of civil monetary 
penalties, revocation of our device clearance, seizure of our products or delay in clearance of future products.  Product clearances or 
approvals by the FDA can be withdrawn due to failure to comply with regulatory standards or the occurrence of unforeseen problems 
following initial clearance or approval.   

Also, the procurement and transplantation of allograft bone tissue is subject to the criminal statute National Organ Transplant 
Act and state rules and regulations which govern, among other things, payments we make to vendors in consideration for the services 
they provide in connection with the recovery and screening of donors. Failure to comply with such laws could result in enforcement 
action against us and a disruption to these product lines (and the revenue associated therewith). 

30 

 
 
Failure  or  alleged  failure  to  comply  with  FDA  and  other  governmental  regulations  can  result  in  investigations  and  other 

regulatory proceedings, which are expensive and could divert management attention. 

If  the  FDA  or  other  governmental  authorities  in  the  United  States  or  abroad  believes  we  are  not  conducting  our  business  in 
compliance  with  applicable  laws  or  regulations,  such  governmental  authority  can  initiate  investigations  or  other  regulatory 
proceedings.  Responding to such investigations and proceedings may cause us to incur substantial costs, and could place a significant 
strain on our financial resources and divert the attention of management from our core business.  We could be subject to proceedings 
to detain or seize our products, product recalls, or operating restrictions, Moreover, governmental authorities can ban or request the 
recall, repair, replacement or refund of the cost of any device or product we manufacture or distribute. Any of the foregoing actions 
could result in decreased sales as a result of negative publicity and product liability claims, and could have a material adverse effect on 
our financial condition, results of operations and prospects.  

We are subject to federal, state and foreign fraud and abuse laws and health information privacy and security laws, which, if 

violated, could subject us to substantial penalties. 

There  are  numerous  U.S.  federal  and  state,  as  well  as  foreign,  laws  pertaining  to  healthcare  fraud  and  abuse,  including  anti-
kickback,  false  claims  and  physician  transparency  laws.  Our  relationships  with  physicians,  providers  and  hospitals  are  subject  to 
scrutiny under  these  laws. We  may  also  be  subject  to patient  privacy regulation by both  the federal  government  and  the  states  and 
foreign jurisdictions in which we conduct our business.   

Healthcare fraud and abuse laws are broad in scope and are subject to evolving interpretation, which could require us to incur 
substantial costs to monitor compliance or to alter our practices if they are found not to be in compliance. Violations of these laws may 
be  punishable  by  criminal  or  civil  sanctions,  including  substantial  fines,  imprisonment  and  exclusion  from  participation  in 
governmental  healthcare  programs.  Despite  implementation  of  a  comprehensive  global  healthcare  compliance  program,  we  cannot 
provide assurance that any of the healthcare fraud and abuse laws will not change or be interpreted in the future in a manner which 
restricts or adversely affects our business activities or relationships with healthcare professionals, nor can we make any assurances that 
authorities will not challenge or investigate our current or future activities under these laws. 

In  July  2015,  we  entered  into  a  settlement  agreement  with  the  DOJ  pursuant  to  which  we  paid  $13.5  million  to  resolve  an 
investigation into possible false or otherwise improper claims submitted to Medicare and Medicaid. We admitted no wrongdoing as 
part  of  the  settlement.    In  August  2015,  we  received  a  CID  issued  by  the  DOJ  pursuant  to  the  federal  False  Claims  Act.  The  CID 
requires the delivery of a wide range of documents and information related to an investigation by the DOJ concerning allegations that 
we  assisted  a  physician  group  customer  in  submitting  improper  claims  for  reimbursement  and  made  improper  payments  to  the 
physician  group  in  violation  of  the  Anti-Kickback  Statute.  We  are  cooperating  with  the  DOJ.  No  assurance  can  be  given  as  to  the 
timing  or  outcome  of  this  investigation.  Responding  to  government  requests  and  investigations  requires  considerable  resources, 
including  the  time  and  attention  of  management.  If  we  were  to  become  the  subject  of  an  enforcement  action,  including  any  action 
resulting from the investigation by the DOJ, it could result in negative publicity, penalties, fines, the exclusion of our products from 
reimbursement under federally-funded programs and/or prohibitions on our ability to sell our products, which could have a material 
adverse effect on our results of operations, financial condition and liquidity 

We may fail to obtain or maintain foreign regulatory approvals to market our products in other countries. 

We currently market our products internationally and intend to expand our international marketing. International jurisdictions 
require separate regulatory approvals and compliance with numerous and varying regulatory requirements. The approval procedures 
vary  among  countries  and  may  involve  requirements  for  additional  testing.  Clearance  or  approval  by  the  FDA  does  not  ensure 
approval  or  certification  by  regulatory  authorities  in  other  countries  or  jurisdictions,  and  approval  or  certification  by  one  foreign 
regulatory authority does not ensure approval or certification by regulatory authorities in other foreign countries or by the FDA. The 
foreign regulatory approval or certification process may include all of the risks associated with obtaining FDA clearance or approval. 
We may not obtain foreign regulatory approvals on a timely basis, if at all. We may  not be able to file for regulatory approvals or 
certifications and may not receive necessary approvals to commercialize our products in any market. If we fail to receive necessary 
approvals or certifications to commercialize our products in foreign jurisdictions on a timely basis, or at all, our business, results of 
operations and financial condition could be adversely affected. 

If we fail to obtain, or experience significant delays in obtaining, FDA clearances or approvals for our future products or 

product enhancements, our ability to commercially distribute and market our products could suffer. 

The  process  of  obtaining  regulatory  clearances  or  approvals  to  market  a  medical  device,  particularly  from  the  FDA,  can  be 
costly and time consuming, and there can be no assurance that such clearances or approvals will be granted on a timely basis, if at all. 
In particular, the FDA permits commercial  distribution of a new medical device only after the device has received clearance under 
Section 510(k) of the Federal Food, Drug and Cosmetic Act, or is the subject of an approved premarket approval application (PMA). 
If clinical trials of our current or future product candidates do not produce results necessary to support regulatory approval, we will be 
unable to commercialize these products, which could have a material adverse effect on our financial results. 

31 

 
 
The  FDA  will  clear  marketing  of  a  medical  device  through  the  510(k)  process  if  it  is  demonstrated  that  the  new  product  is 
substantially  equivalent  to  other  510(k)-cleared  products.  The  PMA  process  is  more  costly,  lengthy  and  uncertain  than  the  510(k) 
clearance  process. Additionally,  any  modification  to  a  510(k)-cleared  device  that  could significantly  affect  its  safety  or  efficacy, or 
that  would  constitute  a  major  change  in  its  intended  use,  requires  a  new  510(k)  clearance  or,  possibly,  a  PMA.  The  FDA  may  not 
agree  with  any  of  our  decisions  regarding  whether  new  clearances  or  approvals  are  necessary.  Our  failure  to  comply  with  such 
regulations  could  lead  to  the  imposition  of  injunctions,  suspensions  or  loss  of  regulatory  approvals,  product  recalls,  termination  of 
distribution, or product seizures. In the most egregious cases, criminal sanctions or closure of our manufacturing facilities are possible. 

The  misuse  or  off-label  use  of  our  products  may  harm  our  reputation  in  the  marketplace,  result  in  injuries  that  lead  to 
product liability suits or result in costly investigations, fines or sanctions by regulatory bodies if we are deemed to have engaged in 
the promotion of these uses, any of which could be costly to our business.  

Pursuant to FDA regulations, we can only market our products for cleared or approved uses.  Although physicians are permitted 
to  use  medical  devices  for  indications  other  than  those  cleared  or  approved  by  the  FDA  based  on  their  medical  judgment,  we  are 
prohibited from promoting products for such off-label uses.  We train our marketing personnel and independent sales agencies and 
distributors  to  not  promote  our  products  for  uses  outside  of  the  FDA-cleared  indications.    Although  we  believe  our  marketing, 
promotional  materials  and  training  programs  for  physicians  do  not  constitute  promotion  of  unapproved  uses  of  our  products,  if  the 
FDA or any foreign regulatory body determines that our marketing, promotional materials or training programs constitute promotion 
of an off-label use, we could be subject to significant fines in addition to regulatory enforcement actions.  It is also possible that other 
federal, state or foreign enforcement authorities might take action under other regulatory authority, such as false claims laws, if they 
consider our business activities to constitute promotion of an off-label use, which could result in significant penalties, including, but 
not limited to, criminal, civil and administrative penalties, damages, fines, disgorgement, exclusion from participation in government 
healthcare programs and the curtailment of our operations. 

In addition, there may be increased risk of injury to patients if physicians attempt to use our products off-label. Furthermore, the 
use  of  our  products  for  indications  other  than  those  cleared  by  the  FDA  or  approved  by  any  foreign  regulatory  body  may  not 
effectively treat such conditions, which could harm our reputation in the marketplace among physicians and patients.  

If  we  or  our  suppliers  fail  to  comply  with  the  FDA’s  quality  system  regulations  or  equivalent  regulations  and  standards 
internationally, the manufacture and processing of our products could be delayed and we may be subject to an enforcement action 
by the FDA or other government agencies. 

We and our suppliers are required to comply with the QSR and other applicable standards and requirements, which cover the 
methods and documentation of the design, testing, production or processing, control, quality assurance, labeling, packaging, storage 
and shipping of our products. The FDA and other regulatory bodies enforce compliance with regulatory requirements and standards 
through  periodic  inspections.  If  we  or  one  of  our  suppliers  fail  an  inspection  or  if  any  corrective  action  plan  is  not  sufficient,  the 
release of our products could be delayed. We have undergone FDA and other regulatory body’s inspections regarding our allograft 
business  and  FDA  inspections  regarding  our  medical  device  activities.  In  connection  with  these  inspections  as  well  as  prior 
inspections, regulatory agencies have requested minor corrective actions, which we have implemented. There can be no assurance that 
the  FDA  will  not  subject  us  to  further  enforcement  action  and  the  FDA  and  other  regulatory  agencies  may  impose  additional 
inspections at any time. 

Additionally,  we  are  the  legal  manufacturer  of  record  for  the  products  that  are  distributed  and  labeled  by  us,  regardless  of 
whether  the  products  are  manufactured  by  us  or  our  suppliers.  Thus,  a  failure  by  us  or  our  suppliers  to  comply  with  applicable 
regulatory requirements can result in enforcement action against us by the FDA, which may include any of the following sanctions: 

•  fines, injunctions, and civil penalties; 
•  recall or seizure of our products; 
•  operating restrictions, partial suspension or total shutdown of production; 
•  refusing our request for 510(k) clearance or premarket approval of new products; 
•  withdrawing 510(k) clearance or premarket approvals that are already granted; and 
•  criminal prosecution. 

32 

 
 
We  or  our  suppliers  may  be  the  subject  of  claims  for  non-compliance  with  FDA  regulations  in  connection  with  the 

processing or distribution of allograft products. 

It  is possible  that  allegations  may  be  made  against  us or against donor recovery groups or  tissue  banks,  including those  with 
which we have a contractual relationship, claiming that the acquisition or processing of tissue for allograft products does not comply 
with  applicable  FDA  regulations  or  other  relevant  statutes  and  regulations.  Allegations  like  these  could  cause  regulators  or  other 
authorities to take investigative or other action against us, or could cause negative publicity for us or our industry in general. These 
actions or any negative publicity could cause us to incur substantial costs, divert the attention of management from our business, harm 
our reputation and cause the market price of our shares to decline. 

Compliance with SEC regulations relating to “conflict minerals” may increase our costs and adversely affect our business.   

We are subject to SEC regulations that require us to determine whether our products contain certain specified minerals, referred 
to  under  the  regulations  as  “conflict  minerals”,  and,  if  so,  to  perform  an  extensive  inquiry  into  our  supply  chain,  in  an  effort  to 
determine whether or not such conflict minerals originate from the Democratic Republic of Congo (“DRC”), or an adjoining country.  
Compliance with these regulations has increased our costs, and we expect our costs may increase in the future.   We have determined 
that certain of our products contain such specified minerals.  As of the date of our conflict minerals report for the 2014 calendar year, 
we were unable to determine whether or not such minerals originate from the DRC or an adjoining country.  We are continuing to 
conduct  inquiries  into  our  supply  chain  in connection  with  the  preparation of our  conflict  minerals  report  for 2015,  which  must  be 
audited by an independent auditor pursuant to existing government auditing standards.  Compliance with these requirements has been 
time-consuming for management and our supply chain personnel (as well as time-consuming for our suppliers), and we expect that 
compliance  will  continue  to require  the  expenditure of significant amounts of  time  and  money  by us  and  them.    In addition,  to  the 
extent any of our disclosures are perceived by the market to be “negative,” it may cause customers to refuse to purchase our products.  
Further, if we determine to make any changes to products, processes, or sources of supply, it may result in additional costs, which may 
adversely affect our business.   

Legislative or regulatory reforms may make it more difficult and costly for us to obtain regulatory clearances or approvals 

for our products or to produce, market or distribute our products after clearance or approval is obtained.  

From  time  to  time,  legislation  is  drafted  and  introduced  in  Congress  that  could  significantly  change  the  statutory  provisions 
governing the regulation of medical devices or the reimbursement thereof. In addition, the FDA regulations and guidance are often 
revised or reinterpreted by the FDA in ways that may significantly affect our business and our products. Any new statutes, regulations 
or revisions or reinterpretations of existing regulations may impose additional costs or lengthen review times of any future products or 
make it more difficult to manufacture, market or distribute our products or future products. We cannot determine what effect changes 
in regulations, statutes, legal interpretation or policies, when and if promulgated, enacted or adopted may have on our business in the 
future. Such changes could, among other things, require:  

•  additional testing prior to obtaining clearance or approval;   
•  changes to manufacturing methods;   
•  recall, replacement or discontinuance of our products or future products; or   
•  additional record keeping.   

Any of these changes could require substantial time and cost and could harm our business and our financial results.  

Our relationships with physician consultants, owners and investors could be subject to additional scrutiny from regulatory 

enforcement authorities and could subject us to possible administrative, civil or criminal sanctions.  

Federal and state laws and regulations impose restrictions on our relationships with physicians who are consultants, owners and 
investors.  We  have  entered  into  consulting  agreements,  license  agreements  and  other  agreements  with  physicians  in  which  we 
provided  stock  options  or  cash  or  both  as  compensation.  Some  of  the  physicians  with  which  we  have  such  consulting  and  other 
agreements are affiliated with some of our customers. Finally, we have other arrangements with physicians, including for research and 
development grants and for other purposes as well.  

We could be adversely affected if regulatory agencies were to interpret our financial relationships with these physicians, who 
may be in a position to influence the ordering of and use of our products for which governmental reimbursement may be available, as 
being in violation of applicable laws. If our relationships with physicians are found to be in violation of the laws and regulations that 
apply to us, we may be required to restructure the arrangements and could be subject to administrative, civil and criminal penalties, 
including exclusion from participation in government healthcare programs, imprisonment, and the curtailment or restructuring of our 
operations, any of which could negatively impact our ability to operate our business and our results of operations.  

33 

 
 
Our  business  involves  the  use  of  hazardous  materials  and  we  and  our  third-party  manufacturers  must  comply  with 

environmental laws and regulations, which may be expensive and restrict how we do business.  

Our  third-party  manufacturers’  activities  and our  own  activities  involve  the  controlled  storage,  use  and disposal  of  hazardous 
materials. We and our manufacturers are subject to federal, state, local and foreign laws and regulations governing the use, generation, 
manufacture,  storage,  handling  and  disposal  of  these  hazardous  materials.  We  currently  carry  no  insurance  specifically  covering 
environmental claims relating to the use of hazardous materials, but we do reserve funds to address these claims at both the federal 
and  state  levels.  Although  we  believe  that  our  safety  procedures  for  handling  and  disposing  of  these  materials  and  waste  products 
comply with the standards prescribed by these laws and regulations, we cannot eliminate the risk of accidental injury or contamination 
from  the  use,  storage,  handling  or  disposal  of  hazardous  materials.  In  the  event  of  an  accident,  state  or  federal  or  other  applicable 
authorities may curtail our use of these materials and interrupt our business operations. In addition, if an accident or environmental 
discharge occurs, or if we discover contamination caused by prior operations, including by prior owners and operators of properties 
we  acquire,  we  could  be  liable  for  cleanup  obligations,  damages  and  fines.  If  such  unexpected  costs  are  substantial,  this  could 
significantly harm our financial condition and results of operations.  

Risks Related to Our Financial Results and Need for Financing 

We may be unable to grow our revenue or earnings as anticipated, which may have a material adverse effect on our future 

operating results. 

We have experienced rapid growth since our inception, and have increased our revenue from $38.4 million in 2004, the year of 
our initial public offering, to $811.1 million in 2015. Our ability to achieve future growth will depend upon, among other things, the 
success of our growth strategies, which we cannot assure will be successful. In addition, we may have more difficulty maintaining our 
prior rate of growth of revenue or recent levels of profitability and cash flow. Our future success will depend upon various factors, 
including  the  strength  of  our  brand  image,  the  market  success  of  our  current  and  future  products,  competitive  conditions  and  our 
ability to manage increased revenue, if any, or implement our growth strategy. In addition, we anticipate significantly expanding our 
infrastructure and adding personnel in connection with our anticipated growth, which we expect will cause our selling, general and 
administrative expenses to increase in absolute dollars and as a percentage of revenue. Because these expenses are generally fixed, 
particularly  in  the  short-to-medium  term,  our  operating  and  financial  results  may  be  adversely  impacted  if  we  do  not  achieve  our 
anticipated growth. 

The  sale  of  our  2.75%  Senior  Convertible  Notes  due  2017  significantly  increased  our  amount  of  long-term  debt,  and  our 

financial condition and results of operations could be adversely affected if we do not efficiently manage our liabilities. 

In June 2011, we  issued  $402.5  million  aggregate principal  amount of  our 2.75%  Senior  Convertible  Notes  due  in 2017  (the 
2017 Notes). As a result of the sale of the 2017 Notes, we have a substantial amount of long-term debt. Our maintenance of such debt 
could adversely affect our financial condition and results of operations. 

In addition, there are a large number of shares of common stock reserved for issuance upon the potential conversion of our 2017 

Notes and the issuance of these shares may depress the market price of our common stock. 

If we fail to comply with the covenants and other obligations under our credit facility, the lenders may be able to accelerate 

amounts owed under the facilities and may foreclose upon the assets securing our obligations.  

In  February  2016,  we  entered  into  a  credit  agreement  with  Bank  of  America,  N.A.,  or  Bank  of  America,  that  provides  for 
secured revolving facility loans, multicurrency loan options and letters of credit in an aggregate amount of up to $150.0 million. The 
credit agreement also contains an expansion feature, which allows us to increase the aggregate principal amount of the credit facility 
provided we remain in compliance with the underlying financial covenants. All of our assets and the assets of our material domestic 
subsidiaries  are  pledged  as  collateral  under  the  credit  facility  (subject  to  customary  exceptions)  and  each  of  our  material  domestic 
subsidiaries guarantee the credit facility. The covenants set forth in the credit agreement restrict, among other things, our ability to: 
create  liens  on  assets,  incur  additional  indebtedness,  make  investments,  make  acquisitions  and  other  fundamental  changes,  sell  and 
dispose of property or assets, pay dividends and other distributions, change the business conducted, engage in certain transactions with 
affiliates,  enter  into  burdensome  agreements,  limit  certain  use  of  proceeds,  amend  organizational  documents,  change  accounting 
policies  or  reporting  practices,  modify  or  terminate  documents  related  to  certain  indebtedness,  enter  into  sale  and  leaseback 
transactions, fund sanctions and use proceeds for any breach of anti-corruption laws. If we fail to comply with the covenants and our 
other obligations under the credit facility, Bank of America would be able to accelerate the required repayment of amounts due under 
the loan agreement and, if they are not repaid, could foreclose upon our assets securing our obligations under the credit facility. 

34 

 
 
We  may  need additional financing  in  the future  to  meet  our  capital  needs or  to  make opportunistic  acquisitions  and  such 

financing may not be available on favorable terms, if at all, and may be dilutive to existing stockholders. 

In furtherance of our growth strategy and global expansion efforts, we intend to continue to invest in our business, including 
through acquisitions and strategic transactions.  These investments will be expensive, and we may need to seek additional financing in 
the future to meet our capital needs.  As of December 31, 2015, we had $470.1 million in cash, cash equivalents and investments in 
marketable securities. Subsequent to December 31, 2015, we paid $380.0 million in connection with the closing of our acquisition of 
Ellipse Technologies, and we incurred costs and expenses in connection with the transaction and our integration activities.   We may 
seek to raise capital from public and private debt and equity offerings, borrowings under our existing or future credit facilities or other 
sources.  We may  be unable  to  obtain  any desired  additional  financing on  terms  favorable  to us,  if  at  all. If  adequate  funds  are  not 
available  on  acceptable  terms,  we  may  be  unable  to  fund  our  expansion,  successfully  develop  or  enhance  products  or  respond  to 
competitive pressures, any of which could negatively affect our business. If we raise additional funds through the issuance of equity 
securities, our stockholders will experience dilution of their ownership interest. If we raise additional funds by issuing debt, we may 
be  subject  to  limitations  on  our  operations  due  to  restrictive  covenants.  Additionally,  our  ability  to  make  scheduled  payments  or 
refinance  our  obligations  will  depend  on  our  operating  and  financial  performance,  which  in  turn  is  subject  to  prevailing  economic 
conditions and financial, business and other factors beyond our control.   

We could be subject to changes in tax rates, the adoption, evolution or change of new and/or amended U.S. or international 

tax legislation or exposure to additional tax liabilities. 

We are subject to taxes in the United States and numerous foreign jurisdictions, including the Netherlands, where a number of 
our subsidiaries are (or were) located. Significant judgment is required to determine and estimate our worldwide tax liabilities. Due to 
economic  and  political  conditions,  tax  rates  in  various  jurisdictions  may  be  subject  to  significant  change.  Our  effective  income  tax 
rates have recently been, and could in the future be adversely affected by changes in tax laws or interpretations of those tax laws, by 
stock-based compensation and other non-deductible expenses, by changes in the mix of earnings in countries with differing statutory 
tax rates, or by changes in the valuation of our deferred tax assets and liabilities. 

As part of our globalization initiative, we have established new international operations and have entered into new intercompany 
transfer pricing arrangements, including the licensing of intangibles. We intend to continue to streamline our international operations 
to better align with and support our international business activities and markets through changes in how we develop, license and use 
our intangible property and how we structure our international procurement and customer service functions. We anticipate a negative 
impact to our effective tax rate over the next several years while achieving an overall reduction to our effective tax rate over the longer 
term. There can be no assurance that the taxing authorities of the jurisdictions in which we operate or will operate or to which we are 
otherwise deemed to have sufficient tax presence will not challenge the tax benefits that we ultimately expect to realize as a result of 
implementing the new structure. In addition, future changes to U.S. or non-U.S. tax laws, including proposed legislation to reform the 
U.S. taxation of international business, could negatively impact the anticipated tax benefits of the proposed new structure. Any long 
term benefits to our tax rate will also depend on our ability to achieve our anticipated international growth projections and to operate 
our business in a manner consistent with the new structure. If we do not operate our business consistent with the new structure and 
applicable tax provisions, we may fail to achieve the financial efficiencies that we anticipate as a result of the new structure and our 
future operating results and financial condition may be negatively impacted. 

Finally, we may be subject in the future to examination of our income tax returns by the Internal Revenue Service and other 
taxing  authorities  which  may  result  in  the  assessment  of  additional  income  taxes.  We  regularly  assess  the  likelihood  of  an  adverse 
outcome resulting from these examinations to determine the adequacy of our provision for taxes. There can be no assurance as to the 
outcome of these examinations. If our effective tax rates were to increase, particularly in the U.S., Ireland, or the Netherlands or if the 
ultimate  determination  of  our  taxes  owed  is  for  an  amount  in  excess  of  amounts  previously  accrued,  our  financial  condition,  cash 
flows or results of operations could be adversely affected. 

Risks Related to the Securities Markets and Ownership of Our Common Stock 

We  expect  that  the  price  of  our  common  stock  will  fluctuate  substantially,  potentially  adversely  affecting  the  ability  of 

investors to sell their shares. 

The market price of our common stock may be subject to wide fluctuations, which may negatively affect the ability of investors 

to sell our shares at consistent prices. Fluctuation in the stock price may occur due to many factors, including, without limitation: 

•  general market conditions and other factors related to the economy or otherwise, including factors unrelated to our operating 

performance or the operating performance of our competitors;  

•  people’s expectations, favorable or unfavorable, as to the likely unit growth of the spine sector; 
•  negative stock market reactions to the results of litigation; 
•  negative  publicity  regarding  spine  surgeon’s  practices  or  outcomes,  whether  warranted  or  not,  that  cast  the  sector  in  a 

negative light; 

35 

 
 
•  the introduction of new products or product enhancements by us or our competitors; 
•  changes in the availability of third-party reimbursement in the United States or other countries; 
•  disputes or other developments with respect to intellectual property rights or other potential legal actions; 
•  our ability to develop, obtain regulatory clearance or approval for, and market new and enhanced products on a timely basis; 
•  quarterly variations in our or our competitor’s results of operations; 
•  sales of large blocks of our common stock, including sales by our executive officers and directors; 
•  announcements of technological or medical innovations for the treatment of spine pathology; 
•  changes in governmental regulations or in the status of our regulatory approvals, clearances or applications; 
•  the acquisition or divestiture of businesses, products, assets or technology by us or by our competitors; 
•  litigation (including intellectual property litigation) and any associated negative verdicts or ruling; 
•  announcements of actions by the FDA or other regulatory agencies; and 
•  changes in earnings or operating margin estimates or recommendations by us or by securities analysts. 

Anti-takeover provisions in our organizational documents and Delaware law may discourage or prevent a change of control, 
even if an acquisition would be beneficial to our stockholders, which could affect our stock price adversely and prevent attempts by 
our stockholders to replace or remove our current management. 

Our certificate of incorporation and bylaws contain provisions that could delay or prevent a change of control of our company or 

changes in our board of directors that our stockholders might consider favorable. Some of these provisions: 

•  authorize the issuance of preferred stock which can be created and issued by the board of directors without prior stockholder 

approval, with rights senior to those of the common stock; 

•  provide for a classified board of directors, with each director serving a staggered three-year term; 
•  provide that our stockholders may remove our directors only for cause; 
•  prohibit  our  stockholders  from  filling  board  vacancies,  calling  special  stockholder  meetings,  or  taking  action  by  written 

consent; 

•  prohibit  our  stockholders  from  making  certain  changes  to  our  certificate  of  incorporation  or  bylaws  except  with  66  2/3% 

stockholder approval; and 

•  require advance written notice of stockholder proposals and director nominations. 

In  addition,  we  are  subject  to  the  provisions  of  Section  203  of  the  Delaware  General  Corporation  Law,  which  may  prohibit 
certain business combinations with stockholders owning 15% or more of our outstanding voting stock. These and other provisions in 
our certificate of incorporation, our bylaws and Delaware law could make it more difficult for stockholders or potential acquirers to 
obtain control of our board of directors or initiate actions that are opposed by our then-current board of directors, including delay or 
impede a merger, tender offer, or proxy contest involving our company. Any delay or prevention of a change of control transaction or 
changes in our board of directors could cause the market price of our common stock to decline. 

We do not intend to pay cash dividends. 

We have never declared or paid cash dividends on our capital stock. We currently intend to retain all available funds and any 
future  earnings  for  use  in  the  operation  and  expansion  of  our  business  and  do  not  anticipate  paying  any  cash  dividends  in  the 
foreseeable future. In addition, the terms of any future debt or credit facility may preclude us from paying any dividends. As a result, 
capital appreciation, if any, of our common stock will be our stockholders’ source of potential gain for the foreseeable future.  

Item 1B.  Unresolved Staff Comments  

None.  

36 

 
 
Item 2. 

Properties  

The following table sets forth our principal properties as of December 31, 2015:  

Description of Use 
Corporate office and training facilities (1) 
Fulfillment and warehouse operations 
Manufacturing facilities 
Office facilities 
Office facilities 
Office facilities 
Office facilities 
Office facilities and warehouse 
Office facilities 

(1) Our corporate headquarters. 

Item 3. 

Legal Proceedings  

Square Footage 

145,765     
100,000     
32,754     
10,579     
10,516     
9,063     
8,588     
7,383     
7,210     

Location 
San Diego, CA
Memphis, TN
Dayton, OH
Columbia, MD
Netherlands
Japan
Australia
Germany
UK

For  a  description  of  our  material  pending  legal  proceedings,  refer  to  “Note  11.  Contingencies”  in  the  Notes  to  Consolidated 

Financial Statements included in this Annual Report. 

Item 4.  Mine Safety Disclosures  

Not applicable.  

Item 5.  Market  for  the  Registrant’s  Common  Equity,  Related  Stockholder  Matters  and  Issuer  Purchases  of  Equity 

PART II 

Securities  

Common Stock Market Price  

Our common stock is traded on the NASDAQ Global Select Market under the symbol “NUVA.” The following table presents 

the high and low per share sale prices of our common stock during the periods indicated, as reported on NASDAQ.  

High 

Low 

2014 

First Quarter 
Second Quarter 
Third Quarter 
Fourth Quarter 

2015 

First Quarter 
Second Quarter 
Third Quarter 
Fourth Quarter 

   $

   $

39.39         $
39.25           
38.22           
48.10           

51.23         $
51.25           
56.61           
55.98           

31.84
32.26
32.48
34.40

42.64
41.52
46.06
44.22  

We had approximately 92 stockholders of record as of January 31, 2016. We believe that the number of beneficial owners is 
substantially  greater  than  the  number  of  record  holders  because  a  large  portion  of  our  common  stock  is  held  of  record  through 
brokerage firms in “street name.”  

Recent Sales of Unregistered Securities  

During the fourth quarter of 2015, we did not issue any securities that were not registered under the Securities Act of 1933, as 

amended (the Securities Act).  

Dividend Policy  

We have never declared or paid any cash dividends on our capital stock. We currently intend to retain future earnings, if any, for 
development of our business and do not anticipate that we will declare or pay cash dividends on our capital stock in the foreseeable 
future. 

37 

 
 
  
  
 
 
 
 
 
 
 
 
 
  
    
    
    
    
 
    
    
  
 
  
  
           
  
    
            
  
 
  
 
  
 
  
    
            
  
 
  
 
  
 
Equity Compensation Plan Information 

The following table provides certain information with respect to all of our compensation plans in effect as of December 31, 2015: 

Plan Category 
Equity Compensation Plans approved by 
stockholders 
Equity Compensation Plans not approved by 
stockholders 
Total 

(A) 
Number of Securities to 
be Issued Upon Exercise
of Outstanding Options,
Warrants and Rights

(B) 
Weighted Average 
Exercise Price of 
Outstanding 
Options, Warrants 
and Rights

(C) 
Number of Securities 
Remaining Available for
Future Issuance Under 
Equity Compensation 
Plans (excluding 
securities reflected in 
column(A))

4,392,843  (1)$

34.91        

2,907,915  (2)(3)

—    

4,392,843     $

—        
34.91        

—    
2,907,915    

(1) 

(2) 

(3) 

Consists  of  shares  subject  to  outstanding  stock  options,  restricted  stock  units  and  performance  restricted  stock 
units under the 2004 Amended and Restated Equity Incentive Plan and the 2014 Equity Incentive Plan, some of 
which  are vested  and  some  of which remain  subject  to  the  vesting  and/or  performance  criteria of  the  respective 
equity award. 

Consists of shares available for future issuance under the 2014 Equity Incentive Plan and 2004 Employee Stock 
Purchase  Plan  (ESPP).  As  of December 31,  2015,  an  aggregate  of  1,358,510  shares  of  common  stock  were 
available for issuance under the 2014 Equity Incentive Plan and 1,549,405 shares of common stock were available 
for issuance under the 2004 Employee Stock Purchase Plan. 

The 2004 Amended and Restated Equity Incentive Plan terminated in February 2014, upon the tenth anniversary 
of its effective date, and we are no longer granting awards under that plan.  However, awards granted under the 
plan will remain outstanding until they are exercised, issued, terminated, cancelled or they expire.  Pursuant to the 
terms of the 2014 Equity Incentive Plan, shares subject to awards granted under the 2004 Amended and Restated 
Equity  Incentive  Plan  may  be  utilized  for  future  grants  of  awards  under  the  2014  Equity  Incentive  Plan,  to  the 
extent such awards are terminated, cancelled or they expire, or shares subject thereto are withheld to cover taxes.  
As the number of these shares is indeterminate, these shares have not been registered for issuance, nor are they 
reflected in the number of shares available for future grant.   

38 

 
 
 
 
  
    
     
    
    
    
 
    
PERFORMANCE GRAPH  

The following graph compares the cumulative total stockholder return data on our common stock with the cumulative return of 
(i) The  NASDAQ  Stock  Market  Composite  Index,  and  (ii) NASDAQ  Medical  Equipment  Index  over  the  five  year  period  ending 
December 31,  2015.  The  graph  assumes  that  $100  was  invested  on  December 31,  2010  in  our  common  stock  and  in  each  of  the 
comparative  indices.  The  stock  price  performance  on  the  following  graph  is  not  necessarily  indicative  of  future  stock  price 
performance.  

The  following  graph  and  related  information  shall  not  be  deemed  “soliciting  material”  or  be  deemed  to  be  “filed”  with  the 
Commission, nor shall such information be incorporated by reference into any future filing, except to the extent that we specifically 
incorporate it by reference into such filing.  

COMPARISON OF 5 YEAR CUMULATIVE TOTAL RETURN* 

AMONG NUVASIVE, INC.,  

THE NASDAQ COMPOSITE INDEX  

AND THE NASDAQ MEDICAL EQUIPMENT INDEX  

$250

$200

$150

$100

$50

$0

12/10 3/11 6/11 9/11 12/11 3/12 6/12 9/12 12/12 3/13 6/13 9/13 12/13 3/14 6/14 9/14 12/14 3/15 6/15 9/15 12/15

NuVasive, Inc.

NASDAQ Composite

NASDAQ Medical Equipment

* 

$100 invested on December 31, 2010 in stock or index, including reinvestment of dividends. 

39 

 
 
 
 
Item  6. 

Selected Financial Data  

The selected consolidated financial data set forth in the table below has been derived from our audited financial statements. The 
data set forth below should be read in conjunction with “Management’s Discussion and Analysis of Financial Condition and Results 
of Operations” and our audited financial statements and notes thereto appearing elsewhere in this report.  

Year Ended December 31, (1) 

2015 

2014 

2013 

2012 

2011 

(In thousands, except per share amounts) 

Statement of Operations Data: 
Total revenues 
Gross profit 
Consolidated net income (loss) 
Net income (loss) attributable to 
NuVasive, Inc. 
Net income (loss) per share attributable 
to NuVasive, Inc.: 

  $ 811,113    $ 762,415    $ 685,173    $ 620,255     $  540,506 
    616,634      580,057      504,689      466,846        428,395 
(71,021)

(17,496)   

65,290     

2,442       

6,985     

66,291     

(16,720)   

7,902     

3,144       

(69,849)

Basic 
Diluted 

  $
  $

1.36    $
1.26    $

(0.36)  $
(0.36)  $

0.18    $
0.17    $

0.07     $ 
0.07     $ 

(1.73)
(1.73)

December 31, (1) 

2015 

2014 

2013 

2012 

2011 

(In thousands, except per share amounts) 

Balance Sheet Data: 
Working capital 
Total assets 
Senior Convertible Notes 
Non-current liabilities (excluding 
convertible notes) 
Non-controlling interests (2) 
Total equity 

  $ 603,210   $ 490,972   $ 418,856   $ 349,474     $  384,457 
    1,289,649     1,343,459     1,179,568     1,163,785       1,123,562 
332,404        394,019 

376,542    

346,060    

360,746    

111,288    
—    
702,202    

119,456    
—    
648,358    

111,478    
—    
604,878    

119,528       
10,003       

17,413 
10,705 
537,575        494,045  

(1)  Consolidated  statement  of  operations  and  balance  sheet  data  for  the  years  ended  December 31,  2015, 

2014, 2013, 2012 and 2011 include Impulse Monitoring from October 7, 2011, the date of acquisition.  

(2)  On June 13, 2013, the non-controlling interest in Progentix Orthobiology, B.V. became non-redeemable 
and therefore was reclassified out of mezzanine equity to its own component of total equity within the 
Company’s consolidated balance sheet.  

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Item 7.  Management’s Discussion and Analysis of Financial Condition and Results of Operations  

As noted earlier, this Annual Report, including the following discussion and analysis, may contain forward-looking statements 
that  involve  risks,  uncertainties,  assumptions  and  other  factors  which,  if  they  do  not  materialize  or  prove  correct,  could  cause  our 
results to differ from historical results or those expressed or implied by such forward-looking statements. Please review this Annual 
Report and the following discussion and analysis in light of the forward-looking statements provisions outlined at the outset of Part I. 

You should read the following discussion and analysis of our financial condition and results of operations in conjunction with 

the Consolidated Financial Statements and the Notes to those statements included in this Annual Report.  

 Overview  

We  are  a  leading  medical  device  company  in  the  global  spine  surgery  market,  focused  on  developing  minimally-disruptive 
surgical  products  and  procedurally-integrated  solutions  for  spine  surgery.  Our  currently-marketed  product  portfolio  is  focused  on 
applications for spine fusion surgery, including biologics used to aid in the spinal fusion process. For the year ended December 31, 
2015, we generated global revenues of $811.1 million, including sales in over 30 countries. 

Our  principal  product  offering  includes  a  minimally-disruptive  surgical  platform  called  Maximum  Access  Surgery,  or  MAS. 
The MAS platform combines three categories of solutions that collectively minimize soft tissue disruption during spine fusion surgery, 
provide  maximum  visualization  and  are  designed  to  enable  safe  and  reproducible  outcomes  for  the  surgeon  and  the  patient.  The 
platform includes our proprietary software-driven nerve detection and avoidance systems, NVM5, and Intraoperative Monitoring, or 
IOM,  services  and  support;  MaXcess,  an  integrated  split-blade  retractor  system;  and  a  wide  variety  of  specialized  implants  and 
biologics. Many of our products, including the individual components of our MAS platform can also be used in open or traditional 
spine  surgery.  Our  spine  surgery  product  line  offerings,  which  include  products  for  the  thoracolumbar  and  the  cervical  spine,  are 
primarily used to enable surgeon access to the spine to perform restorative and fusion procedures in a minimally-disruptive fashion.  
We also recently launched Integrated Global Alignment, or iGA, in which products and computer assisted technology under our MAS 
platform  help  achieve  more  precise  spinal  alignment.  Our  biologics  products,  which  are  used  to  aid  in  the  spinal  fusion  process  or 
bone  healing  process  include  allograft  (donated  human  tissue)  and  synthetic  offerings.    In  addition,  following  our  acquisition  of 
Ellipse  Technologies,  Inc.,  or  Ellipse  Technologies,  which  closed  in  February  2016,  we  now  offer  magnetically  adjustable  implant 
systems based on the MAGnetic External Control, or MAGEC, technology platform. We continue to focus significant research and 
development efforts to expand our MAS product platform and advance the applications of our unique technology into procedurally-
integrated  surgical  solutions  that  improve  clinical  and  economic  outcomes.  We  have  dedicated  and  continue  to  dedicate  significant 
resources toward training spine surgeons around the world; both those who are new to our MAS product platform, as well as ongoing 
education for MAS-trained surgeons attending advanced courses.  

During 2015, specifically in the first quarter, our former Chief Executive Officer and Chairman of the Board resigned from such 
roles, and in the second quarter our Board of Directors appointed Gregory T. Lucier, a Director since 2013, to be our Chief Executive 
Officer and Chairman of the Board. 

Revenues and Operations 

To date, the majority of our revenues are derived from the sale of implants, biologics and disposables and we expect this trend to 
continue for the foreseeable future. We loan our proprietary software-driven nerve monitoring systems and surgical instrument sets at 
no cost to surgeons and hospitals that purchase disposables and implants for use in individual procedures. In addition, we often place 
our proprietary software-driven nerve monitoring systems, MaXcess and other MAS or cervical surgical instrument sets with hospitals 
for an extended period at no up-front cost to them. Our implants, biologics and disposables are currently sold and shipped from our 
primary distribution and warehousing operations facility located in Memphis, Tennessee. We generally recognize revenue for implants, 
biologics  and  disposables  upon  receiving  acknowledgement  of  a  purchase  order  and  upon  completion  of  delivery.  We  sell  MAS 
instrument sets, MaXcess devices, and our proprietary software-driven nerve monitoring systems, however this does not make up a 
material part of our business. 

The majority of our operations are located and the majority of our sales have been generated in the United States. We sell our 
products  in  the  United  States  through  a  sales  force  comprised  of  exclusive  independent  sales  agents  and  directly-employed  sales 
representatives,  both  engaged  to  sell  only  NuVasive  products.  Our  sales  force  provides  a  delivery  and  consultative  service  to  our 
surgeon  and  hospital  customers  and  is  compensated  based  on  sales  and  product  placements  in  their  territories.  Sales  force 
commissions are reflected in our statement of operations in the sales, marketing and administrative expenses line. We are continuing 
to invest in our expansion of international sales efforts with the focus on European, Asia-Pacific and Latin American markets. Our 
international sales force is comprised of directly-employed sales shareowners as well as exclusive distributors and independent sales 
agents. As of December 31, 2015, we did not have any significant backlog. 

41 

 
 
Critical Accounting Policies  

Our discussion and analysis of our financial condition and results of operations is based upon our audited consolidated financial 
statements, which have been prepared in accordance with accounting principles generally accepted in the United States (GAAP). The 
preparation  of  these  financial  statements  requires  us  to  make  estimates  and  judgments  that  affect  the  reported  amounts  of  assets, 
liabilities, revenues and expenses. On an ongoing basis, we evaluate our estimates including those related to revenue recognition, bad 
debts,  inventories,  valuation  of  financial  instruments,  goodwill,  intangibles,  property  and  equipment,  stock-based  compensation, 
income taxes, and legal proceedings. We base our estimates on historical experience and on various other assumptions we believe to 
be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets 
and liabilities not readily apparent from other sources. Actual results may differ from these estimates.  

We  believe  the  following  accounting  policies  to  be  critical  to  the  judgments  and  estimates  used  in  the  preparation  of  our 

consolidated financial statements.   

Revenue Recognition 

In  accordance  with  the  Commission’s  guidance,  we  recognize  revenue  when  all  four  of  the  following  criteria  are  met: 
(i) persuasive evidence that an arrangement exists; (ii) delivery of the products and/or services has occurred; (iii) the selling price is 
fixed or determinable; and (iv) collectability is reasonably assured. Specifically, revenue from the sale of implants and disposables is 
generally  recognized  upon  acknowledgement  of  a  purchase  order  from  the  hospital  indicating  product  use  or  implantation  or  upon 
shipment  to  third-party  customers  who  immediately  accept  title.  Revenue  from  the  sale  of  our  instrument  sets  is  recognized  upon 
receipt of a purchase order and the subsequent shipment to customers who immediately accept title. Instrument sales account for an 
immaterial amount of annual sales.  

Allowance for Doubtful Accounts and Sales Return Reserve 

We  maintain  an  allowance  for  doubtful  accounts  for  estimated  losses  resulting  from  the  inability  of  our  customers  to  make 
required  payments.  The  allowance  for  doubtful  accounts  is  reviewed  quarterly  and  is  estimated  based  on  the  aging  of  account 
balances, collection history and known trends with current customers and in the economy in general. As a result of this review, the 
allowance  is  adjusted  on  a  specific  identification  basis  for  significant  accounts  and  a  general  reserve  approach  for  non-significant 
accounts.  We  also  review  the  overall  quality  and  age  of  those  invoices  not  specifically  identified.  In  determining  the  provision  for 
invoices  not  specifically  reviewed,  we  analyze  historical  collection  experience  and  current  economic  trends.  An  increase  to  the 
allowance  for doubtful  accounts  results  in  a  corresponding  charge  to  sales,  marketing  and  administrative  expenses. If  the historical 
data  used  to  calculate  the  allowance  provided  for  doubtful  accounts  does  not  reflect  the  our  future  ability  to  collect  outstanding 
receivables or if the financial condition of customers were to deteriorate, resulting in impairment of their ability to make payments, an 
increase in the provision for doubtful accounts may be required. We maintain a relatively large customer base that mitigates the risk of 
concentration with any one particular customer.  Historically, our reserves have been adequate to cover losses. 

In addition, we establish a reserve for estimated sales returns and pricing adjustments that is recorded as a reduction to revenue. 
This reserve is maintained to account for future return of products or pricing adjustments on products sold in the current period. This 
reserve  is  reviewed  quarterly  and  is  estimated  based  on  an  analysis  of  our  historical  experience  and  expected  future  trends. 
Historically, the Company’s reserves have been adequate to account for returns and pricing adjustments. 

Inventory 

Inventory consists primarily of purchased finished goods, which includes specialized implants and disposables, and is stated at 
the lower of cost or market determined by utilizing a standard cost method which approximates the weighted average cost. We review 
the components of our inventory on a periodic basis for excess and obsolescence and record a reserve for the identified items. 

Excess and Obsolete Inventory 

We  provide  an  inventory  reserve  for  estimated  obsolescence  and  excess  inventory  based  upon  historical  turnover  and 
assumptions about future demand for our products and market conditions. Our allograft products have shelf lives ranging from two to 
five years and are subject to demand fluctuations based on the availability and demand for alternative products. Our inventory, which 
consists primarily of disposables and specialized implants, is at risk of obsolescence following the introduction and development of 
new or enhanced products. Our estimates and assumptions for excess and obsolete inventory are reviewed and updated on a quarterly 
basis.  The  estimates  we  use  for  demand  are  also  used  for  near-term  capacity  planning  and  inventory  purchasing  and  are  consistent 
with our revenue forecasts. Increases in the reserve for excess and obsolete inventory result in a corresponding charge to cost of goods 
sold.  Historically our reserves have been adequate to cover losses. 

A stated goal of our business is to focus on continual product innovation and to obsolete our own products. While we believe 
this provides a competitive edge, it also results in the risk that our products and related capital instruments will become obsolete prior 
to sale or to the end of their anticipated useful lives.  

42 

 
 
Fair Value of Financial Instruments 

ASC  Topic  820,  Fair  Value  Measurements  and  Disclosures, defines  fair  value  and  requires  us  to  establish  a  framework  for 
measuring  fair  value  and  disclosure  about  fair  value  measurements.  The  framework  requires  the  valuation  of  assets  and  liabilities 
subject to fair value measurements using a three tiered approach and fair value measurement be classified and disclosed in one of the 
following  three  categories.  Inputs  to  valuation  techniques  are  observable  or  unobservable.  Observable  inputs  reflect  market  data 
obtained from independent sources, while unobservable inputs reflect our market assumptions.  

Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities.  

Level 2: Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.  

Level 3: Unobservable inputs are used when little or no market data is available.  

Carrying value of the financial instruments measured and classified within Level 1 is based on quoted prices. 

The types of instruments that trade in markets that are not considered to be active, but are valued based on quoted market prices, 
broker or dealer quotations, or alternative pricing sources with reasonable levels of price transparency are generally classified within 
Level 2 of the fair value hierarchy.  

Certain  contingent  consideration  liabilities  are  classified  within  Level  3  of  the  fair  value  hierarchy  because  they  use 
unobservable  inputs.  For  those  liabilities,  fair  value  is  determined  using  a  probability-weighted  discounted  cash  flow  model,  the 
significant inputs which are not observable in the market.  

Cash and Cash Equivalents 

We consider all highly liquid investments that are readily convertible into cash and have an original maturity of three months or 

less at the time of purchase to be cash equivalents.  

Marketable Securities 

We  define  marketable  securities  as  income  yielding  securities  that  can  be  readily  converted  into  cash.  Marketable  securities 
consist  of  certificates  of  deposit,  corporate  notes,  commercial  paper,  U.S.  government  treasury  securities,  and  securities  of 
government-sponsored entities.  

We classify all such securities as available-for-sale as the sale of such securities may be required prior to maturity to implement 
management strategies. These securities are carried at fair value with the unrealized gains and losses reported as a component of other 
comprehensive income in equity until realized. Realized gains and losses and declines in value judged to be other-than-temporary, if 
any, on available-for-sale securities are included in other income or expense on the Consolidated Statements of Operations and a new 
accounting cost basis for the security is established in the period in which it occurs. We review our investments if there is an indicator 
of  possible  other-than-temporary  impairment.  Factors  considered  in  determining  whether  a  loss  is  other-than-temporary  include  the 
length of time and extent to which fair value has been less than the cost basis, the financial condition and near-term prospects of the 
investee,  and  our  intent  and  ability  to  hold  the  investment  for  a  period  of  time  sufficient  to  allow  for  any  anticipated  recovery  in 
market value. Premiums and discounts are amortized or accreted over the life of the related security as an adjustment to yield using the 
straight-line  method  and  are  included  in  interest  income  on  the  Consolidated  Statements  of  Operations.  Interest  and  dividends  on 
securities classified as available-for-sale are also included in interest income on the Consolidated Statements of Operations. Realized 
gains and losses from the sale of marketable securities, if any, are determined on a specific identification basis. Realized gains and 
losses and interest income related to marketable securities were immaterial during all periods presented. 

We  maintain  an  investment  policy  that  requires  a  diversified  investment  portfolio  in  terms  of  types,  maturities,  and  credit 
exposure,  and  invests  with  institutions  that  have  high  credit  quality.  Annually,  we  reassess  the  investment  policy  to  ensure  it  is 
reflective of current markets and conditions. We do not currently hold financial instruments for speculative purposes. 

Derivatives 

We  maintain  a  foreign  currency  risk  management  strategy  that  uses  derivative  instruments  to  protect  against  fluctuations  in 
earnings and cash flows that may rise from volatility in currency exchange rates. We use foreign currency forward exchange contracts 
to  hedge  the  currency  exchange  rate  exposure  from  short-term  intercompany  receivables  and  payables  denominated  in  a  currency 
other  than  the  reporting  entity’s  functional  currency.  Realized  and  unrealized  gains  or  losses  forward  contracts  are  included  in  the 
determination of net income as the forward contracts are not designated for hedge accounting under ASC Topic 815, Derivatives and 
Hedging. The foreign currency forward contracts effectively lock in the exchange rate at which the specific intercompany receivables 
and payables will be settled, so that gains or losses on the forward contracts offset the gains or losses from changes in the value of the 
underlying receivables and payables. The forward contracts are generally settled monthly. 

43 

 
 
Valuation of Goodwill and Intangible Assets with Indefinite Lives 

Our goodwill represents the excess of the cost over the fair value of net assets acquired from our business combinations. The 
determination  of  the  value  of  goodwill  and  intangible  assets  arising  from  business  combinations  and  asset  acquisitions  requires 
extensive use of accounting estimates and judgments to allocate the purchase price to the fair value of the net tangible and intangible 
assets  acquired,  including  capitalized  in-process  research  and  development,  or  IPR&D.  Intangible  assets  acquired  in  a  business 
combination that are used for IPR&D activities are considered indefinite lived until the completion or abandonment of the associated 
research  and  development  efforts.  Upon  reaching  the  end  of  the  relevant  research  and  development  project,  we  will  amortize  the 
acquired  in-process  research  and  development  over  its  estimated  useful  life  or  expense  the  acquired  in-process  research  and 
development should the research and development project be unsuccessful with no future alternative use. 

 Goodwill and IPR&D are not amortized; however, they are assessed for impairment using fair value measurement techniques 
on an annual basis or more frequently if facts and circumstance warrant such a review. The goodwill or IPR&D are considered to be 
impaired if we determine that the carrying value of the reporting unit or IPR&D exceeds its respective fair value.    

We  perform  our  goodwill  impairment  analysis  at  the  reporting  unit  level,  which  aligns  with  our  reporting  structure  and 
availability of discrete financial information. We perform our annual impairment analysis by either doing a qualitative assessment of a 
reporting unit’s fair value from the last quantitative assessment to determine if there is potential impairment, or comparing a reporting 
unit’s estimated fair value to its carrying amount. We may do a qualitative assessment when the results of the previous quantitative 
test indicated the reporting unit’s estimated fair value was significantly in excess of the carrying value of its net assets and we do not 
believe there have been significant changes in the reporting unit’s operations that would significantly decrease its estimated fair value 
or significantly increase its net assets. If a quantitative assessment is performed the evaluation includes management estimates of cash 
flow  projections  based  on  internal  future  projections  and/or  use  of  a  market  approach  by  looking  at  market  values  of  comparable 
companies. Key assumptions for these projections include revenue growth, future gross and operating margin growth, and its weighted 
cost of capital and terminal growth rates. The revenue and margin growth is based on increased sales of new and existing products as 
we maintain our investment in research and development. Additional assumed value creators may include increased efficiencies from 
capital  spending.  The  resulting  cash  flows  are  discounted  using  a  weighted  average  cost  of  capital.  Operating  mechanisms  and 
requirements  to  ensure  that  growth  and  efficiency  assumptions  will  ultimately  be  realized  are  also  considered  in  the  evaluation, 
including  timing  and  probability  of  regulatory  approvals  for  our  products  to  be  commercialized.  Our  market  capitalization  is  also 
considered as a part of this analysis. 

Our annual evaluation for impairment of goodwill consists of two reporting units; the Progentix reporting unit and the remainder 
of the Company. In accordance with our policy, we completed our most recent annual evaluation for impairment as of October 1, 2015 
and determined that no impairment existed, and it was determined that no reporting unit of the Company was at risk of impairment 
when  assessing  the  unit’s  fair  value  compared  to  its  carrying  value.  In  addition,  no  indicators  of  impairments  were  noted  through 
December 31, 2015 and consequently, no impairment charge has been recorded during the year. 

In October 2015, we obtained 510(k) clearance from the Food and Drug Administration authorizing us to market the primary 
sales product associated with the Progentix reporting unit in the United States. Previously, the product, a synthetic biologic, was only 
sold internationally. The 510(k) clearance does not guarantee future performance, and our actual results may differ materially from 
those forecasted in the impairment analysis. 

Valuation of Intangible Assets 

Our intangible assets are comprised primarily of purchased technology, customer relationships, manufacturing know-how and 
trade secrets, and trade name and trademarks. We make significant judgments in relation to the valuation of intangible assets resulting 
from business combinations and asset acquisitions.   

Intangible assets are amortized on a straight-line basis over their estimated useful lives of 1 to 17 years. We base the useful lives 
and related amortization or depreciation expense on the period of time we estimate the assets will generate revenues or otherwise be 
used by the Company. We also periodically review the lives assigned to our intangible assets to ensure that our initial estimates do not 
exceed any revised estimated periods from which we expect to realize cash flows from the technologies. If a change were to occur in 
any of the above-mentioned factors or estimates, the likelihood of a material change in our reported results would increase.   

We evaluate our intangible assets with finite lives for indications of impairment whenever events or changes in circumstances 
indicate  that  the  carrying value  may  not  be  recoverable. Factors  that  could  trigger  an impairment  review  include  significant  under-
performance relative to expected historical or projected future operating results, significant changes in the manner of our use of the 
acquired assets or the strategy for our overall business or significant negative industry or economic trends. If this evaluation indicates 
that the value of the intangible asset may be impaired, we make an assessment of the recoverability of the net carrying value of the 
asset  over  its  remaining  useful  life.  If  this  assessment  indicates  that  the  intangible  asset  is  not  recoverable,  based  on  the  estimated 
undiscounted  future  cash  flows  of  the  technology  over  the  remaining  amortization  period,  we  reduce  the  net  carrying  value  of  the 
related intangible asset to fair value and may adjust the remaining amortization period.  

44 

 
 
During the year ended December 31, 2014, we recorded an impairment charge of $10.7 million related to developed technology 
acquired  from  Cervitech  in  2009.  The  primary  factor  contributing  to  this  impairment  charge  was  the  reduction  in  management’s 
revenue estimate and the related decrease to the estimated cash flows for this technology.  

Significant judgment is required in the forecasts of future operating results that are used in the discounted cash flow valuation 
models.  It  is  possible  that  plans  may  change  and  estimates  used  may  prove  to  be  inaccurate.  If  our  actual  results,  or  the  plans  and 
estimates used in future impairment analyses, are lower than the original estimates used to assess the recoverability of these assets, we 
could incur additional impairment charges.  

Valuation of Stock-Based Compensation 

Stock-based  compensation  expense  for  equity-classified  awards,  principally  related  to  restricted  stock  units,  or  RSUs,  and 
performance  restricted  stock  units,  or  PRSUs,  is  measured  at  the  grant  date  based  on  the  estimated  fair  value  of  the  award  and  is 
recognized over the employee’s requisite service period on an accelerated basis. The fair value of equity instruments that are expected 
to  vest  is  recognized  and  amortized  over  the  requisite  service  period.  We  have  granted  awards  with  up  to  five  year  graded  or  cliff 
vesting terms (in each case, with service through the date of vesting being required). No exercise price or other monetary payment is 
required for receipt of the shares issued in settlement of the respective award; instead, consideration is furnished in the form of the 
participant’s service to the Company. 

The fair value of RSUs including PRSUs with pre-defined performance criteria is based on the stock price on the date of grant 
whereas  the  expense  for  PRSU  with  pre-defined  performance  criteria  is  adjusted  with  the  probability  of  achievement  of  such 
performance criteria at each period end. The fair value of the PRSUs that are earned based on the achievement of pre-defined market 
conditions for total shareholder return, or TSR PRSUs, is estimated on the date of grant using a Monte Carlo valuation model. The key 
assumptions in applying this model are an expected volatility and a risk-free interest rate.  

Stock-based  compensation  expense  is  adjusted  from  the  grant  date  to  exclude  expense  for  awards  that  are  expected  to  be 
forfeited. The forfeiture estimate is adjusted as necessary through the vesting date so that full compensation cost is recognized only for 
awards  that  vest.  We  assess  the  reasonableness  of  the  estimated  forfeiture  rate  at  least  annually,  with  any  change  to  be  made  on  a 
cumulative basis in the period the estimated forfeiture rates change. We considered our historical experience of pre-vesting forfeitures 
on awards by each homogenous group of shareowners as the basis to arrive at our estimated annual pre-vesting forfeiture rates. 

We estimate the fair value of stock options issued under our equity incentive plans and shares issued to shareowners under our 
employee  stock  purchase  plan  using  a  Black-Scholes  option-pricing  model  on  the  date  of  grant.  The  Black-Scholes  option-pricing 
model incorporates various and highly sensitive assumptions including expected volatility, expected term and risk-free interest rates. 
The expected volatility is based on the historical volatility of our common stock over the most recent period commensurate with the 
estimated  expected  term  of  our  stock  options  and  ESPP  which  is  derived  from  historical  experience.  The  risk-free  interest  rate for 
periods  within  the  contractual  life  of  the  option  is  based  on  the  U.S. Treasury  yield  in  effect  at  the  time  of  grant.  We  have  never 
declared or paid dividends and have no plans to do so in the foreseeable future.  

Stock-based compensation expense was $26.2 million, $33.7 million, and $33.2 million for 2015, 2014, and 2013, respectively.  
Stock-based compensation expense decreased $7.5 million in 2015 compared to 2014. This decrease in 2015 was primarily attributed 
to the increase award forfeitures, including awards of key executives that left the Company during 2015. Stock-based compensation 
expense for 2014 and 2013 was relatively consistent. 

As of December 31, 2015, there was approximately $13.5 million and $25.1 million of unrecognized compensation expense for 
RSUs and PRSUs, respectively, which is expected to be recognized over a weighted-average period of approximately 1.8 years and 
3.3 years, respectively. In addition, as of December 31, 2015, there was $0.7 million of unrecognized compensation expense for shares 
expected to be issued under the Employee Stock Purchase Plan which is expected to be recognized through April 2016. There was no 
unrecognized amortization expense for stock options as of December 31, 2015. 

Accounting for Income Taxes 

The asset and liability approach is used to recognize deferred tax assets and liabilities for the expected future tax consequences 
of  temporary  differences  between  the  carrying  amounts  and  the  tax  bases  of  assets  and  liabilities.  Tax  law  and  rate  changes  are 
reflected  in  income  in  the  period  such  changes  are  enacted.  The  Company  includes  interest  and  penalties  related  to  income  taxes, 
including unrecognized tax benefits, within income tax expense. 

45 

 
 
The Company’s income tax returns are based on calculations and assumptions that are subject to examination by the Internal 
Revenue  Service  and  other  tax  authorities.  In  addition,  the  calculation  of  the  Company’s  tax  liabilities  involves  dealing  with 
uncertainties in the application of complex tax regulations. The Company recognizes liabilities for uncertain tax positions based on a 
two-step  process.  The  first  step  is  to  evaluate  the  tax  position  for  recognition  by  determining  if  the  weight  of  available  evidence 
indicates that it is more likely than not that the position will be sustained on audit, including resolution of related appeals or litigation 
processes, if any. The second step is to measure the tax benefit as the largest amount that is more than 50% likely of being realized 
upon  settlement.  While  the  Company  believes  it  has  appropriate  support  for  the  positions  taken  on  its  tax  returns,  the  Company 
regularly assesses the potential outcomes of examinations by tax authorities in determining the adequacy of its provision for income 
taxes.  The  Company  continually  assesses  the  likelihood and  amount  of  potential  adjustments  and  adjusts  the  income  tax  provision, 
income taxes payable and deferred taxes in the period in which the facts that give rise to a revision become known. 

The  Company  recognizes  windfall  tax  benefits  associated  with  share-based  awards  directly  to  stockholders’  equity  when 
realized.  A  windfall  tax  benefit  occurs  when  the  actual  tax  benefit  realized  by  the  Company  upon  an  employee’s  disposition  of  a 
share-based award exceeds the deferred tax asset, if any, associated with the award that the Company had recorded. When assessing 
whether  excess  tax  benefits  relating  to  share-based  compensation  have  been  realized,  the  Company  follows  the  with-and-without 
approach excluding any indirect effects of the excess tax deductions. Under this approach, excess tax benefits related to share-based 
compensation are not deemed to be realized until after the utilization of all other tax benefits available to the Company. 

Significant judgment is required in determining our provision for income taxes, our deferred tax assets and liabilities and the 
valuation allowance recorded against our net deferred tax assets. Deferred tax assets and liabilities are determined using the enacted 
tax rates in effect for the years in which those tax assets are expected to be realized. A valuation allowance is established when it is 
more likely than not the future realization of all or some of the deferred tax assets will not be achieved. The evaluation of the need for 
a valuation allowance is performed on a jurisdiction-by-jurisdiction basis, and includes a review of all available positive and negative 
evidence. Factors reviewed include projections of pre-tax book income for the foreseeable future, determination of cumulative pre-tax 
book income after permanent differences, earnings history, and reliability of forecasting. 

Based on our review, we concluded that it was more likely than not that we would be able to realize the benefit of our domestic 
and foreign deferred tax assets, with the exception of California, in the future. This conclusion was primarily based on historical and 
projected  operating  performance,  as  well  as  our  expectation  that  our  operations  will  generate  sufficient  taxable  income  in  future 
periods to realize the tax benefits associated with the deferred tax assets well within the statutory carryover periods. However, due to 
the inclusion of foreign losses, lower state apportionment, and the generation of research credits in California, we concluded that it is 
not  more  likely  than  not  that  we  will  be  able  to  utilize  our  California  deferred  tax  assets.  Therefore,  we  have  maintained  a  full 
valuation allowance on our California deferred tax assets as of December 31, 2015.       

We will continue to assess the need for a valuation allowance on our deferred tax assets by evaluating both positive and negative 
evidence  that  may  exist.  Any  adjustment  to  the  net  deferred  tax  asset  valuation  allowance  would  be  recorded  in  the  statement  of 
operations for the period that the adjustment is determined to be required.  

Legal Proceedings 

We  are  involved  in  a  number  of  legal  actions  arising  out  of  the  normal  course  of  our  business.  The  outcomes  of  these  legal 
actions are not within our complete control and may not be known for prolonged periods of time. In some actions, the claimants seek 
damages as well as other relief, including injunctions barring the sale of products that are the subject of the lawsuit, that could require 
significant expenditures or result in lost revenues. In accordance with authoritative guidance, we disclose information regarding each 
material claim where the likelihood of a loss contingency is probable or reasonably possible. An estimated loss contingency is accrued 
in  our  financial  statements  if  it  is  both  probable  that  a  liability  has  been  incurred  and  the  amount  of  the  loss  can  be  reasonably 
estimated. If a loss is reasonably possible and can be reasonably estimated, the estimated loss or range of loss is disclosed in the notes 
to the consolidated financial statements. In most cases, significant judgment is required to estimate the amount and timing of a loss to 
be  recorded.  Our  significant  legal  proceedings  are  discussed  in  Note  11  to  the  consolidated  financial  statements  included  in  this 
Annual Report.  

The  above  listing  is  not  intended  to  be  a  comprehensive  list  of  all  of  our  accounting  policies.  In  many  cases,  the  accounting 
treatment of a particular transaction is specifically dictated by GAAP. See our Consolidated Financial Statements and Notes thereto 
included in this Annual Report, which contain accounting policies and other disclosures required by GAAP.  

46 

 
 
Results of Operations  

Revenue  

2015 

Year Ended December 31, 
2014 
(Dollars in thousands) 

2013 

2014 to 2015 

2013 to 2014 

  $ Change  

  % Change   

   $ Change  

  % Change   

Spine Surgery Products 
Biologics 

Total revenue 

  $ 678,891    $632,845    $569,540    $ 46,046      
2,652      
    132,222      129,570      115,633     
  $ 811,113    $762,415    $685,173    $ 48,698      

7 %   $  63,305     
2 %      13,937     
6 %   $  77,242     

11%
12%
11%

Our  spine  surgery  product  line  offerings,  which  include  products  for  the  thoracolumbar  product  offerings,  cervical  product 
offerings,  IOM  services,  and  disposables,  are  primarily  used  to  enable  access  to  the  spine  and  to  perform  restorative  and  fusion 
procedures  in  a  minimally-disruptive  fashion.  Our  biologic  product  line  offerings  include  allograft  (donated  human  tissue), 
FormaGraft (a  collagen  synthetic  product),  Osteocel Plus  and  Osteocel Pro  (each  an  allograft  cellular  matrix  containing  viable 
mesenchymal stem cells, or MSCs), Propel DBM (a highly moldable demineralized bone matrix putty), and AttraX (a synthetic bone 
graft material), all of which are used to aid the spinal fusion or bone healing process. 

The  continued  adoption  of  minimally  invasive  procedures  for  spine  has  led  to  the  expansion  of  our  procedure  volume.  In 
addition, increased market acceptance in our international markets contributed to the increase in revenues for the periods presented. 
We  expect  continued  adoption  of  our  innovative  minimally  invasive  procedures  and  deeper  penetration  into  existing  accounts  and 
international markets  as our  sales force  executes on our strategy of  selling  the  full  mix of our  products  and  services. However,  the 
continued consolidation and increased purchasing power of our hospital customers and group purchasing organizations, the continued 
existence of physician-owned distributorships, recent changes in the public and private insurance markets regarding reimbursement, 
and  ongoing  policy  and  legislative  changes  in  the  United  States  have  created  less  predictability  in  the  lumbar  portion  of  the  spine 
market and have limited the domestic spine market’s procedural growth rate. Accordingly, we believe that our growth in revenue in 
2016 will come primarily from share gains in the shift toward less invasive spinal surgery and international growth. 

Our total revenues increased $48.7 million in 2015 compared to 2014 and $77.2 million in 2014 compared to 2013, representing 
total  revenue growth of 6% and  11%, respectively.  To  date,  foreign  currency  fluctuations  have not materially  impacted our overall 
revenues.  

Revenue from our Spine Surgery Products increased $46.0 million, or 7%, in 2015 compared to 2014 and $63.3 million, or 11%, 
in  2014  compared  to  2013.  These  increases  resulted  from  increased  volume  of  approximately  10%  and  14%  for  the  years  ended 
December 31, 2015 and 2014 respectively, compared to the prior periods, offset by unfavorable changes in price of approximately 1% 
and  2%  for  2015  and  2014,  respectively,  compared  to  the  respective  prior  periods,  and  an  unfavorable  change  in  foreign  currency 
fluctuation of approximately 2% for 2015 compared to 2014.  

Revenue  from  Biologics  increased  $2.7  million,  or  2%,  in  2015  compared  to  2014,  and  $13.9  million,  or  12%,  in  2014 
compared  to  2013.  These  increases  resulted  from  increases  in  volume  of  approximately  3%  and  12%  for  the  years  ended 
December 31,  2015  and  2014,  respectively,  compared  to  the  prior  periods.  Increase  in  revenue  in  2015  was  offset  by  small 
unfavorable  changes  in  price  of  approximately  1%  compared  to  the  same  period  in  2014.    The  impact  from  changes  in  price  was 
insignificant in 2014 comparing to the same period in 2013. 

Cost of Goods Sold, excluding amortization of purchased technology  

2015 

Year Ended December 31, 
2014 
(Dollars in thousands) 

2013 

2014 to 2015 
  $ Change      % Change   

2013 to 2014 
  $ Change    % Change  

Cost of Goods Sold 
% of total revenue 

  $ 194,479     $182,358     $180,484     $ 12,121      

7 %   $  1,874     

1%

24%   

24%   

26%      

Cost  of  goods  sold  consists  primarily  of  purchased  goods,  raw  materials,  labor  and  overhead  associated  with  product 
manufacturing, inventory-related costs and royalty expenses, as well as the cost of providing IOM services, which includes personnel 
and  physician  oversight  costs.  We  primarily  procure  and  manufacture  our  goods  in  the  United  States,  and  accordingly,  foreign 
currency fluctuations have not materially impacted our cost of goods sold. 

Cost of goods sold as a percentage of revenue remained consistent for the year ended December 31, 2015 compared to 2014. 
The  improvements  in  gross  margin  from  2014  to  2015,  as  a  result  of  expiring  royalty  obligations  for  certain  product  lines,  were 
partially offset by obsolescence of existing products due to our new product launch and sales price decreases. 

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Cost  of  goods  sold  as  a  percentage  of  revenue  decreased  during  the  year  ended  December 31,  2014  compared  to  2013.  This 
decrease in cost of goods sold as a percentage of revenue, which resulted in higher gross margin, was primarily due to an approximate 
2% decrease in cost or reserve requirements due to inventory efficiencies and margin improvements gained from the acquisition of the 
spine  implant  manufacturer  ANC,  LLC  in  May  2013  (now  named  “NuVasive  Manufacturing  Limited”)  and  overall  operational 
efficiencies  realized  during  2014  including  increased  medical  billing  collections  and  volume  in  monitoring  services.  In  addition, 
during  2013,  a  non-recurring  royalty  charge  of  $7.9  million,  or  1%  as  a  percentage  of  revenue,  was  recognized  related  to  the 
Medtronic litigation ruling that determined ongoing royalty rates (see Note 11 to the Consolidated Financial Statements included in 
this Annual Report for further discussion). These improvements were offset by sales price decreases, incremental royalty charges due 
to an increased revenue base and a shift of revenue mix towards lower margin products and countries during 2014, by approximately 
1%.   

On a long term basis, we expect cost of goods sold, as a percentage of revenue, to decrease moderately.  

Operating Expenses  

Sales, marketing, and administrative 

  $ 464,530  

 $468,285    $420,064    $ (3,755)    

(1 )%  $ 48,221   

11%

Year Ended December 31, 

2014 to 2015 

2013 to 2014 

2015 

2014 

2013 

$ Change    % Change   

 $ Change   % Change  

(Dollars in thousands) 

% of total revenue 
Research and development 
% of total revenue 
Amortization of intangibles 
% of total revenue 

Impairment of intangible assets 

% of total revenue 

Litigation liability 

% of total revenue 
Business transition costs 
% of total revenue 

57%    

61%   

61%     

     35,851  

   37,986      32,209     

(2,135)    

(6 )%     5,777   

18%

4%   

5%  

5%     

     12,516  

   13,571      19,326     

(1,055)    

(8 )%     (5,755)  

(30)%

2%   

—  
—%   

2%  
   10,708     
1%  
   30,000     
4%  
1,363     
—%  

     (41,826) 

(5)%  

6,480  

1%   

3%     

—      (10,708)  
—%     
—      (71,826)    
—%     
—     
—%     

5,117     

*   

    10,708 

(239 )%     30,000 

375 %      1,363 

*  

*  

*  

Sales, Marketing and Administrative  

 Sales,  marketing  and  administrative  expenses  consist  primarily  of  compensation  costs,  commissions  and  training  costs  for 
shareowners  engaged  in  sales,  marketing  and  customer  support  functions.  The  expense  also  includes  commissions  to  sales 
representatives, freight expenses, surgeon training costs, depreciation expense for property and equipment such as surgical instrument 
sets, and administrative expenses for both shareowners and third party service providers.   

Sales,  marketing  and  administrative  expenses  decreased  by  $3.8  million  or  1%  during  the  year  ended  December  31,  2015 
compared to the same period in 2014, primarily related to decreases of $5.1 million in freight and legal expenses, a decrease of $7.0 
million in facilities expense primarily related to the 2014 charge as a result of exiting the majority of our New Jersey lease prior to the 
end of  the  lease  term,  and  a  decrease of  $3.3  million  in  other general  operating  expenses.  These  decreases  were partially  offset  by 
increases  of  $4.3  million  in  commissions  to  sales  representatives,  which  is  a  function  of  the  increase  in  revenue  and  international 
expansion,  $3.6  million  in  depreciation  of  loaned  systems  and  instrument  sets,  $3.3  million  in  expenses  for  third  party  service 
providers, and $1.1 million in compensation expenses, primarily as a result of former executives leaving the company. 

Sales,  marketing  and  administrative  expenses  increased  by  $48.2  million  or  11%  during  the  year  ended  December  31,  2014 
compared to the same period in 2013, driven by the costs associated with the expansion in our international and domestic  markets, 
which primarily consists of an increase in direct and indirect sales force’s salary, benefits, and commissions of $29.8 million, and an 
increase in freight, equipment and depreciation expense of $5.4 million. Facility related charges increased $10.5 million in connection 
with  company-wide  efficiency  efforts.  Legal  expenses  also  increased  by  $1.6  million  which  primarily  related  to  certain  intellectual 
property and litigation related legal matters.  

As a percentage of revenue, sales, marketing and administrative expenses decreased from 2014 to 2015 and increased from 2013 
to 2014 due to improved operating efficiencies and because of non-recurring expenses incurred during 2014, including facility charges 
and  increased  legal  expenses  during  2014.  On  a  long-term  basis,  we  expect  total  sales,  marketing  and  administrative  costs,  as  a 
percentage  of  revenue,  to  decrease  moderately.  To  date,  foreign  currency  fluctuations  have  not  materially  impacted  our  sales, 
marketing, and administrative expense. 

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Research and Development 

 Research  and  development  expense  consists  primarily  of  product  research  and  development,  clinical  trial  and  study  costs, 
regulatory  and  clinical  functions,  and  compensation  and  other  shareowner  related  expenses.  In  the  last  several  years,  we  have 
introduced  numerous  new  products  and  product  enhancements  that  have  significantly  expanded  our  MAS  platform,  including  iGA, 
enhanced the applications of the XLIF procedure, and our comprehensive product portfolio. We have also acquired complementary 
and  strategic  assets  and  technology,  particularly  in  the  area  of  spine  surgery  products.  We  continue  to  invest  in  research  and 
development programs. 

Research and development expense decreased by $2.1 million in 2015 compared to 2014. The decrease is primarily related to 
decreases  in  shareowner  travel  expenses,  shareowner  stock-based  compensation,  and  reduction  in  expense  related  to  prototypes  for 
new  product  launches  that  occurred  in  the  current  year.  These  decreases  were  partially  offset  by  increases  in  equipment  expenses 
related to iGA software development projects and other research and development projects and grants. 

Research and development expense increased by $5.8 million in 2014 compared to 2013 primary related to compensation and 
other shareowner related expenses due to increased headcount and the costs related to ongoing development projects of $5.5 million in 
2014,  and  increased  expenses  of  $0.7  million  related  to  facility  and  depreciation  charges.    These  expenses  were  partially  offset  by 
reduction  in  expenses  of  $0.9  million  related  to  acquisitions  of  in-process  research  and  development  intangible  assets  charged  to 
expense in 2014 compared to 2013. 

Research  and  development  costs  as  a  percentage  of  revenue  have  remained  relatively  consistent  with  the  previous  year. 
However, on a long-term basis, we expect total research and development costs as a percentage of revenue to increase moderately in 
support of our ongoing development and regulatory approval efforts. 

Amortization of Intangible Assets  

 Amortization  of  intangible  assets  relates  to  the  amortization  of  finite-lived  intangible  assets  acquired.  Amortization  expense 
decreased $1.1 million in 2015 compared to 2014, and $5.8 million in 2014 compared to 2013, respectively, primarily due to certain 
intangible assets reaching the end of their useful lives subsequent to each year end. During the year ended December 31, 2015, we 
assigned definite lives to certain intangible assets amounting to $15.3 million in book value, and began amortizing the assets of the 
respective lives. 

We expect amortization of our current intangible assets as a percentage of revenue to be relatively consistent. 

Impairment of Intangible Assets  

 During  the  years  ending  December 31,  2014  we  recorded  $10.7  million  of  impairment  charges  related  to  intangible  assets 
acquired  from  Cervitech  in  2009. The primary  factor  contributing  to  these  impairment  charges were the  reduction  in  management's 
estimates of current and future revenue and the related cash flows due to updated views of the competitive and regulatory landscape in 
the cervical market.  

Litigation Liability 

Litigation liability gain of $41.8 million for the year ended December 31, 2015 primarily related to the recognition of a $56.4 
million gain stemming from a favorable appeal in Phase 1 of the Medtronic litigation, which revised the award for lost profits and 
convoyed sales, and a gain of $2.8 million in litigation accrual change related to the settlement of the NeuroVision trademark litigation 
reducing the accrual from $30.0 million to $27.2 million. The litigation liability gains were partially offset by litigation liability losses 
of $13.8 million in connection with the OIG investigation and $3.6 million in general litigation matters. See Note 11 and Note 12 to 
the Consolidated Financial Statements included in this Annual Report for further discussion. 

The litigation liability loss of $30 million for the year ended December 31, 2014 related to the unfavorable jury verdict that was 
delivered against us for the aforementioned NeuroVision trademark litigation. The amount of the jury verdict represented the probable 
loss that we reasonably estimated at that time. See Note 11 to the Consolidated Financial Statements included in this Annual Report 
for further discussion. 

Business Transition Costs 

We incur costs related to integration and business transition activities which include severance, relocation, consulting, and other 
costs  directly  related  to  such  activities.  During  the  year  ended  December  31,  2015,  we  incurred  $6.5  million  of  such  costs,  which 
included a $3.4 million charge in the first quarter associated with the resignation of the Company’s former Chief Executive Officer 
and  Chairman  of  the  Board.  The  $3.4  million  charge  includes  certain  severance  and  compensation-related  charges,  net  of  certain 
forfeitures of previously recognized equity-based compensation. 

49 

 
 
Interest and Other Expense, Net  

Interest income 
Interest expense 
Other income (expense), net 
Total interest and other expense, net 
% of total revenue 

2015 

2013 

Year Ended December 31, 
2014 
(Dollars in thousands) 
 $
755  
   (27,178) 
3,101  
 $(23,322) 

 $
968  
   (27,911) 
(2,411) 
 $(29,354) 

  $  1,589  
    (29,078) 
425  
  $ (27,064) 

2014 to 2015 
$ Change    % Change   

2013 to 2014 
 $ Change   % Change  

 $

621     
(1,167)    
2,836     
 $ 2,290     

64 %   $ 
(4 )%    

213   
(733)  
(118 )%     (5,512)  
8 %   $  (6,032)  

28%
(3)%
(178)%
(26)%

(3)%  

(4)%  

(3)%     

Total interest and other expense, net, consists principally of interest expense incurred on our 2017 Senior Convertible Notes, and 

other income (expense), offset by income earned on marketable securities.  

Total interest and other expense, net, decreased by $2.3 million for the year ended December 31, 2015 compared to the same 
period in 2014. The interest expense increased by $1.2 million during the year ended December 31, 2015, compared to 2014 for the 
same period due to amortization of the debt discount. Other income, net increased $2.8 million during the year ended December 31, 
2015 compared to 2014 due to the losses on foreign currency rate changes in 2014 of $2.6 million, net of hedges, compared to a gain 
on foreign currency rate changes, net of hedges, of $0.3 million in 2015. 

Total  interest and other  expense, net,  increased  by $6.0 million for  the  year  ended December 31, 2014  compared  to  the  same 
period in 2013. The interest expense increased by $0.7 million during the year ended December 31, 2014 compared to 2013 for the 
same period due to amortization of the debt discount offset with lower interest expense incurred due to the 2013 Senior Convertible 
Notes settlement during March 2013. The increase in other expense, net, of $5.5 million during the year ended December 31, 2014, 
compared to 2013 for the same period was due to the recognition of other income of approximately $2.8 million in connection with 
the settlement of several lawsuits related to a competitor in 2013, and losses on foreign currency rate changes in 2014 of $2.6 million, 
net of hedges. The loss on foreign currency was primarily due to the fluctuation in the pound sterling, the euro, the Australian dollar 
and the yen. 

Income Tax Expense   

Income tax expense 
Effective income tax rate 

Year Ended December 31, 
2014 

2013 

2015 

2014 to 2015 
  $ Change      % Change   

2013 to 2014 
  $ Change    % Change  

(Dollars in thousands) 

  $  46,729   $ 6,286  
42%  

(56)%  

28%      

$ 2,783     $ 40,443      

643 %   $  3,503     

126%

The  provision  for  income  taxes  as  a  percentage  of  pre-tax  income  from  continuing  operations  was  42%  for  the  year  ended 
December 31,  2015  compared  with  negative  56%  for  the  year  ended  December 31,  2014.  The  effective  tax  rate  for  2015  is  more 
normalized and higher than 2014 primarily due to small prior year domestic earnings offset by larger foreign losses in jurisdictions 
where we get little to no tax benefit. 

The effective tax rate for 2014 was negative 56% compared to 28% in 2013. The effective tax rate for 2014 was negative mainly 
due  to  the  negative  impact  from  our  Globalization  Initiative  project  and  non-deductible  expenses  primarily  relating  to  executive 
compensation,  offset  by  general  business  and  domestic  manufacturing  credits  and  discrete  benefits  relating  to  disqualifying 
dispositions of qualified stock grants. 

In  January  2013,  the  American  Taxpayer  Relief  Act  of  2012  was  signed  into  law  in  the  U.S.  This  legislation  includes  the 
temporary extension of several expired business tax incentives retroactively to calendar year 2012 and prospectively through calendar 
year 2013. Among the expired tax provisions was the research and development tax credit. The effects of the change in the tax law 
were recognized in our first quarter of 2013, the quarter during which the law was enacted. Because of the timing of enactment, we 
effectively benefited from two years’ worth of research and development credits in 2013 for a total benefit to tax expense in 2013 of 
approximately $1.7 million. 

We are subject to audits by federal, state, local, and foreign tax authorities. We believe that adequate provisions have been made 
for any adjustments that may result from tax examinations. However, the outcome of tax audits cannot be predicted with certainty. 
Should any issues addressed in our tax audits be resolved in a manner not consistent with management’s expectations, we could be 
required to adjust our provision for income taxes in the period such resolution occurs.  

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We expect our future effective income tax rate to exceed the U.S federal and statutory income tax rates due to various factors, 
including non-deductible expenses, state income taxes, net of federal benefits, and the continuing impacts of the implementation of 
our  planned  globalization  initiative  which  became  effective  in  January  2014.  The  initiative  involved  establishing  new  international 
operations  and  entering  into  new  intercompany  transfer  pricing  arrangements,  including  the  transfer  of  intangibles.  We  continue  to 
streamline  our  international  operations,  including  procurement,  logistics  and  customer  service  functions,  in  an  effort  to  improve 
overall operational efficiencies. As international tax rules and regulations change, we may be subjected to changes in tax rates. 

Liquidity, Cash Flows and Capital Resources  

Liquidity and Capital Resources  

Our  principal  sources  of  liquidity  are  our  existing  cash,  cash  equivalents  and  marketable  securities,  cash  generated  from 
operations and proceeds from our convertible debt financing issued in June 2011. We expect that cash provided by operating activities 
may  fluctuate  in  future  periods  as  a  result  of  a  number  of  factors,  including  fluctuations  in  our  operating  results,  working  capital 
requirements  and  capital  deployment  decisions.  We  have  historically  invested  our  cash  primarily  in  the  U.S.  treasuries  and 
government agencies, corporate debt, and money market funds. Certain of these investments are subject to general credit, liquidity and 
other market risks. The general condition of the financial markets and an economy may increase those risks and may affect the value 
and liquidity of our current investments and restrict our ability to access the capital markets. 

Our  future  capital  requirements  will  depend  on  many  factors  including  our  rate  of  revenue  growth,  the  timing  and  extent  of 
spending to support development efforts, the expansion of sales, marketing and administrative activities, the timing of introductions of 
new  products  and  enhancements  to  existing  products,  successful  vertical  integration  of  our  manufacturing  process,  the  continuing 
market  acceptance  of  our  products,  the  expenditures  associated  with  possible  future  acquisitions  or  other  business  combination 
transactions,  the  outcome  of  current  and  future  litigation,  the  evolution  of  our  globalization  initiative,  and  continuous  international 
expansions of our business. We believe that the Company’s cash flow from operations and growing operations will continue to fund 
the ongoing core business.  As we assess inorganic growth strategies, we will need to supplement our internally generated cash flow 
with outside sources. In the event that we are required to access the debt market, we believe we can do so at reasonable borrowing 
rates. As part of our liquidity strategy, we will continue to monitor our current level of earnings and cash flow generation as well as 
our ability to access the market in light of those earning levels. 

A substantial portion of our operations are located in the United States, and the majority of our sales and cash generation since 
inception  have  been  made  in  the  United  States.  Accordingly,  we  do  not  have  material  cash  flow  exposure  to  foreign  currency  rate 
fluctuations. However, as our business in markets outside of the United States continues to increase, we will be exposed to foreign 
currency  exchange  risk  related  to  our  foreign  operations.  Fluctuations  in  the  rate  of  exchange  between  the  United  State  dollar  and 
foreign currencies, primarily in the pound sterling, the euro, the Australian dollar, the Singapore dollar, and the yen, could adversely 
affect  our  financial  results,  including  our  revenues,  revenue  growth  rates,  gross  margins,  income  and  losses  as  well  as  assets  and 
liabilities. We enter into forward currency contracts to partially offset the impact from fluctuations of the foreign currency rates on our 
short-term intercompany receivables and payables between our domestic and international operations. At December 31, 2015, the cash 
balance held by our foreign subsidiaries was approximately $17.8 million and it is our intention to indefinitely reinvest all of current 
foreign earnings in order to partially support foreign working capital and to expand our existing operations outside the United States.  
As  of  December  31,  2015,  $20.9  million  of  account  receivable  was  held  in  other  than  United  States  dollar.  We  have  operations  in 
markets  in  which  there  is  governmental  instability  which  could  impact  funds  that  flow  into  the  medical  reimbursement  system. In 
addition, loss of financial stability within these markets could lead to delays in reimbursement or inability to remit payment due to 
currency controls.  Specifically, we have operations in Puerto Rico, Greece, Argentina and Venezuela. We do not have any material 
financial exposure to one customer or one country that would significantly hinder our liquidity. 

In  connection  with  the  Medtronic  litigation,  a  jury  from  the  U.S.  District  Court,  Southern  District  of  California  delivered  an 
unfavorable verdict to us and awarded monetary damages of approximately $101.2 million to Medtronic. In May 2012, in accordance 
with  an  escrow  arrangement,  we  transferred  $113.3  million  of  cash  into  a  restricted  escrow  account  to  secure  the  amount  of  the 
judgment, plus prejudgment interest, during pendency of our appeal of the judgment. During 2013, we and Medtronic entered into a 
settlement agreement fully resolving the second phase of the case and we made a one-time payment to Medtronic of $7.5 million.  In 
March 2015, the Court of Appeals ruled in favor of us, overturning the previous ruling that Medtronic was entitled to, among other 
things, lost profits. We have thus reduced our royalty accrual and long-term litigation liability by $56.4 million during the year ended 
December 31, 2015. Accordingly, our accrual for the Medtronic litigation as of December 31, 2015 was $88.3 million in long-term 
liabilities. As a result of the March 2, 2015 Court of Appeals decision upholding the jury’s findings of liability as to all patents, but 
overturning the damage award against us as improper, we were no longer required to escrow funds related to Phase I of the ongoing 
litigation. During  the  year  ended  December  31,  2015,  the  funds  in  escrow,  approximately  $114.1  million,  were  returned  to  our 
unrestricted  investment  accounts  from  our  long-term  restricted  cash  and  investments.  In  the  event  that  we  have  a  significant  cash 
outflow  related  to  the  litigation,  the  cash  will  be  funded  through  our  unrestricted  cash  and  investments.  See  Note  11  to  the 
Consolidated Financial Statements included in this Annual Report for further discussion. 

51 

 
 
On April 3, 2014, an unfavorable jury verdict was delivered against us relating to our use of the trade name “NeuroVision”. At 
that time, we established a liability of $30.0 million for this matter. During the year ended December 31, 2015, we agreed to settle all 
outstanding matters related to this matter for $27.2 million. We previously escrowed funds totaling $32.5 million to secure the amount 
of judgment and cover potential attorney’s fees and costs. Those funds were released from escrow to fund the settlement during the 
year ended December 31, 2015.  

In  2013,  we  received  a  federal  administrative  subpoena  from  the  Office  of  the  Inspector  General  of  the  U.S.  Department  of 
Health  and  Human  Services,  or  the  OIG,  in  connection  with  an  investigation  into  possible  false  or  otherwise  improper  claims 
submitted  to  Medicare  and Medicaid.  In  July  2015, we  entered  into  a definitive  settlement  agreement  with  the U.S. Department  of 
Justice,  or  DOJ,  to  settle  this  matter,  and  under  the  terms  of  the  agreement,  we  agreed  to  pay  $13.5  million  plus  fees  and  accrued 
interest of approximately $0.3 million to resolve this matter. The settlement was not an admission of liability or wrongdoing, and we 
were  not  required  to  enter  into  a  corporate  integrity  agreement  with  the  OIG  as  part  of  the  settlement.  In  accordance  with  the 
authoritative guidance on the evaluation of loss contingencies, we recorded a $13.8 million liability related to this matter, and funded 
the settlement during the year ended December 31, 2015.  

On August 31, 2015, we received a civil investigative demand, or CID, issued by the DOJ pursuant to the federal False Claims 
Act. The CID requires the delivery of a wide range of documents and information related to an investigation by the DOJ concerning 
allegations  that  we  assisted  a  physician  group  customer  in  submitting  improper  claims  for  reimbursement  and  made  improper 
payments to the physician group in violation of the Anti-Kickback Statute. We are cooperating with the DOJ. No assurance can be 
given as to the timing or outcome of this investigation, and the probable outcome of this matter cannot be determined. 

On January 4, 2016, we entered into a definitive agreement to acquire Ellipse Technologies for an upfront payment of $380.0 
million  at  the  closing  and  a  potential  milestone  payment  of  $30.0  million  payable  in  2017  related  to  the  achievement  of  specific 
revenue  targets.  The  closing of  the  acquisition  occurred on  February 11,  2016,  and  Ellipse  Technologies  is now our wholly-owned 
subsidiary. In connection with the closing, we used approximately $380.0 million of our available cash and investments on hand to 
pay the upfront payment to security holders of Ellipse Technologies, as well as related transaction fees and expenses. 

In furtherance of our initiative to increase the amount of products that we self-manufacture, in 2015 we added an approximately 
179,000 square foot manufacturing facility in Dayton, Ohio and announced our plans to build out and equip the new facility in order to 
expand our internal manufacturing efforts. 

Cash, cash equivalents and marketable securities was $470.1 million and $405.8 million at December 31, 2015 and December 
31,  2014,  respectively.  We  believe  that  our  existing  cash,  cash  equivalents,  marketable  securities  and  available  liquidity  will  be 
sufficient to meet our anticipated cash needs for the next 12 months. The change in cash during the year ended December 31, 2015 
was mainly driven by our funding litigation settlements, including the trademark infringement settlement of $27.2 million, and $13.5 
million for the OIG settlement, cash tax payments on behalf of shareowners with net share settlement of $56.9 million, cash paid for 
purchased intangibles of $32.0 million which includes $27.4 million which was accrued for in the fourth quarter of 2014, and $36.3 
million  in  income  tax  obligations,  and  ordinary  seasonal  payments  such  as  annual  bonuses.  At  December  31,  2015,  we  have  cash 
totaling $5.6 million in restricted accounts which are not available to us to meet any ongoing capital requirements if and when needed. 
Future litigation or requirements to escrow funds could materially impact our liquidity and our ability to invest in and run our business 
on an ongoing basis.  

Cash Flows  

The following table summarizes our consolidated statements of cash flows (in thousands):  

Year Ended December 31, 

2014 to 2015 

2013 to 2014 

2015 

2014 

2013 

  $ Change  

 % Change   

   $ Change  

  $  88,727    $ 115,548    $ 97,439    $ (26,821)     
Cash provided by operating activities 
     (7,514)     (104,825)     (64,570)     97,311      
Cash used in investing activities 
30,277      (52,482)     (60,621)     
     (30,344)    
Cash (used in) provided by financing activities 
Effect of exchange rate changes on cash 
521      
(861)    
(1,438)    
(917)    
Increase (decrease) in cash and cash equivalents   $  49,952    $ 39,562    $ (20,474)   $ 10,390      

Cash flows from operating activities  

(23 )%   $  18,109     
93 %       (40,255)    
200 %       82,759     
36 %      
(577)    
(26 )%   $  60,036     

 % Change  
19%
(62)%
158%
67%
293%

Cash provided by operating activities was $88.7 million in 2015, compared to $115.5 million in 2014. The decrease of $26.8 
million  in  cash  provided  by  operating  activities  was  primarily  due  to  increases  in  cash  income  tax  obligations  and  the  payment  of 
litigation settlements, partially offset by cash generated from operations and accrual adjustments. 

52 

 
 
  
  
  
 
 
  
  
  
  
  
   
 
 
 
    
Cash provided by operating activities was $115.5 million in 2014, compared to $97.4 million in 2013. The increase of $18.1 
million cash provided by operating activities was primarily due to cash inflow from changes in net operating assets of $39.0 million 
and increased non-cash add backs of $3.6 million, which was offset by the decrease in net income of $24.5 million. The change in net 
operating assets included a litigation liability accrual of $30.0 million we recognized during the year ended December 31, 2014 and 
increased payroll accrual of $4.0 million due to increased headcount in support of our expanding domestic and international operations. 
Non-cash add backs were primarily driven by adding back an impairment charge of $10.7 million, offset with a change in deferred 
income  tax  benefit  of  $11.9  million  which  includes  the  impact  from  the  aforementioned  litigation  accrual  (see  Note  9  to  the 
Consolidated Financial Statements included in this Annual Report for further discussion). Cash flows from operating activities also 
included $13.6 million of cash tax payments in 2014, net with the incremental tax benefit related to stock based compensation of $11.9 
million which is considered cash flows from financing activities. 

Cash flows used in investing activities  

Cash used in investing activities was $7.5 million in 2015, compared to $104.8 million in 2014. The $97.3 million decrease in 
cash  used  in  investing  activities  in  2015  as  compared  to  2014  is  primarily  due  to  the  proceeds  resulting  from  transferring  $114.1 
million of restricted  cash  and  investments  into unrestricted  cash  and  investment  accounts,  and  a $25.9  million  increase  in proceeds 
from the sales and maturities of marketable securities, offset by $17.3 million increase in purchases of property, plant, and equipment, 
and  $32.0  million  in  cash  paid  for  intangible  assets,  including  payment  of  $27.4  million  for  intangible  assets  that  were  payable  at 
December 31, 2014. 

Cash used in investing activities was $104.8 million in 2014, compared to $64.6 million in 2013. The $40.3 million increase in 
cash used in investing activities in 2014 as compared to 2013 is primarily due to a net increase in purchases of marketable securities of 
$44.0 million, including restricted investments and increases in purchases of property and equipment of $10.8 million, offset by less 
cash  paid  for  acquisitions  and  investments  by  $14.3  million.  Additionally,  we  had  an  accrual  of  $27.4  million  as  of  December  31, 
2014 for the purchase of intangible assets which was paid in early 2015. 

For 2016, we expect capital expenditures to support expansions of our business globally to be in the range of $70.0 million to 
$80.0 million  which  is  expected  to  be  sourced  by  the  cash  generated  from  operations  and  the  credit  facility,  as  described  below  in 
section “Revolving Senior Credit Facility”. 

In 2016, we completed the acquisition of Ellipse Technologies, paying $380.0 million using available cash and investments on 
hand. See Note 13 to the Consolidated Financial Statements included in this Annual Report for further discussion of the acquisition of 
Ellipse Technologies. 

Cash flows from financing activities  

Cash used in financing activities was $30.3 million in 2015, compared to cash provided by financing activities of $30.3 million 
in  2014.  The  $60.6  million  increase  in  cash  used  in  financing  activities  is  primarily  due  to  purchases  of  treasury  shares  of  $56.9 
million in 2015 for employee minimum tax withholding payments, and decrease in cash proceeds received in the exercise of employee 
stock options.   

Our  equity  incentive  plans  allow  for  “net  share  settlement”  of  certain  equity  awards  whereby,  in  lieu  of  (i)  making  cash 
payments in satisfaction of the exercise price owed respective to non-qualified stock option awards, or (ii) open market selling award 
shares to generate cash proceeds for use in satisfaction of statutory tax obligations respective to an award’s settlement or exercise, we 
offset the award shares being settled in a respective transaction by the number of shares of company stock with a value equal to the 
respective obligation, and, in the case of taxes, making a cash payment to the respective taxing authority on behalf of the shareowner 
using our cash on hand. The net share settlement is accounted for with the cost of any award shares that are net settled being included 
in treasury stock and reported as a reduction in total equity at the time of settlement. 

During 2016, we approximate at least $30.0 million of such cash tax payments will be made, however the actual remittance can 
be largely different depending on our share price at the date of RSU or PRSU release or option exercises or actual volume of such 
activities. We anticipate using cash generated from operating activities and the credit facility to fund all such payments. 

Cash provided by financing activities was $30.3 million in 2014, compared to cash used in financing activities of $52.5 million 
in  2013.  The  $82.8  million  increase  in  cash  provided  by  financing  activities  is  primarily  due  to  the  repayment  of  the  2013  Senior 
Convertible  Notes  of  $74.3  million  made  in  2013  and  the  increase  in  cash  proceeds  from  the  issuance  of  common  stock  of  $14.9 
million, offset by purchases of treasury shares of $3.8 million in 2014 for employee minimum tax withholding payments, and decrease 
in excess tax benefit of $1.7 million related to stock based compensations.   

53 

 
 
Senior Convertible Notes 

In June 2011, we issued $402.5 million principal amount of Senior Convertible Notes with a stated interest rate of 2.75% and a 
maturity  date  of July 1,  2017.  The  net  proceeds  from  the  offering,  after  deducting  initial  purchasers'  discounts  and  costs  directly 
related  to  the  offering,  were $359.2  million.  The  2017  Notes  may  be  settled  in  cash,  stock,  or  a  combination  thereof,  solely  at  our 
discretion. It is our current intent and policy to settle all conversions through combination settlement, which involves repayment of an 
amount  of  cash  equal  to  the  principal  amount  and  any  excess  of  the  conversion  value  over  the  principal  amount  in  shares  of  the 
Company’s common stock. The initial conversion rate of the 2017 Notes is 23.7344 shares per $1,000 principal amount, or equivalent 
to  conversion  price  of  approximately $42.13 per  share,  which  is  subject  to  adjustment.  Interest  on  the  2017  Notes  is  payable  semi-
annually on January 1st and July 1st of each year. 

In connection with the offering of the 2017 Notes, we entered into convertible note hedge transactions (the “2017 Hedge”) with 
the  initial  purchasers  and/or  their  affiliates  (the  Counterparties)  entitling  us  to  purchase  up  to 9,553,096 shares  of  the  Company’s 
common stock at an initial stock price of $42.13 per share, each of which is subject to adjustment. The cost of the 2017 Hedge was 
$80.1  million.  The  2017  Hedge  expires  on  July 1,  2017.  The  2017  Hedge  is  expected  to  reduce  the  potential  equity  dilution  upon 
conversion of the 2017 Notes if the daily volume-weighted average price per share of the Company’s common stock exceeds the strike 
price of the 2017 Hedge.  

In  addition,  we  sold  warrants  to  the  Counterparties  to  acquire  up  to 477,654 shares  of  the  Company’s  Series  A  Participating 
Preferred  Stock  (the  2017  Warrants),  at  an  initial  strike  price  of $988.51 per  share,  subject  to  adjustment.  Each  share  of  Series  A 
Participating  Preferred  Stock  is  initially  convertible  into 20 shares  of  the  Company’s  common  stock.  The  2017  Warrants  expire  on 
various dates from September 2017 through January 2018 and may be settled in cash or net shares.  It is our current intent and policy 
to settle all conversions in shares of the Company’s common stock, should the conversion occur.  We received $47.9 million in cash 
proceeds from the sale of the 2017 Warrants. The 2017 Warrants could have a dilutive effect on the Company’s earnings per share to 
the  extent  that  the  price  of  the  Company’s  common  stock  during  a  given  measurement  period  (the  quarter  or  year-to-date  period) 
exceeds the strike price of the 2017 Warrants. 

Revolving Senior Credit Facility 

In  February  2016,  we  entered  into  a  Credit  Agreement  (the  “Credit  Agreement”)  for  a  revolving  senior  credit  facility  that 
provides for secured revolving loans, multicurrency loan options and letters of credit in an aggregate amount of up to $150.0 million, 
expiring February 2021. The Credit Agreement also contains an expansion feature, which allows us to increase the aggregate principal 
amount of the facility provided we remain in compliance with the underlying financial covenants. Borrowings under the facility are 
used by us to provide financing for working capital and other general corporate purposes, including potential mergers and acquisitions. 
In February 2016, we made a draw of $50.0 million on the Credit Agreement. See Note 13 to the Consolidated Financial Statements 
included in this Annual Report for further discussion of the Credit Agreement and facility. 

Contractual Obligations and Commitments  

Contractual obligations and commitments represent future cash commitments and liabilities under agreements with third parties, 
including our 2017  Senior  Convertible  Notes  (the  “2017 Notes”), operating  leases  and  other  contractual  obligations.  The following 
table summarizes our long-term contractual obligations and commitments as of December 31, 2015 (in thousands):  

Payments Due by Period 

2017 Notes(1) 
Operating leases 
Capital leases 
Uncertain tax liabilities 
Total 

Total 
424,638    $
55,638     
736     
7,079     
488,091    $

  $

  $

Less Than 
1 Year 

413,569   

     1 to 3 Years        4 to 5 Years       After 5 Years  
— 
17,111 
— 
— 
17,111   

 $ 
15,918        
182        
6,881        
436,550      $ 

—    $
12,908     
—     
198     
13,106    $

11,069    $
9,701     
554     
—     
21,324    $

(1)  See Note 6 to the Consolidated Financial Statements included in this Annual Report for further 

discussion of the terms of the 2017 Notes. 

Total  contractual  obligations  exclude  potential  contingent  consideration  payments  pursuant  to  certain  purchase  or  product 
development agreements.  See Note 4 to the Consolidated Financial Statements included in this Annual Report for further discussion 
on the contingent consideration obligations. 

The  expected  timing  of  payments  of  the  obligations  discussed  above  is  estimated  based  on  current  information.  Timing  of 
payment and actual amounts paid may be different depending on the time of receipt of services or changes to agreed-upon amounts for 
some obligations.  

54 

 
 
  
       
    
 
  
  
    
   
   
   
Off-Balance Sheet Arrangements  

As of December 31, 2015, we did not have any off-balance sheet activities.  

Item 7A.  Quantitative and Qualitative Disclosures About Market Risk 

Interest Rate Sensitivity and Risk 

Our  exposure  to  interest  rate  risk  at  December 31,  2015  is  related  to  our  investment  portfolio  which  consists  largely  of  debt 
instruments  of  high  quality  corporate  issuers  and  the  U.S. government  and  its  agencies.  Due  to  the  short-term  nature  of  these 
investments,  we  have  assessed  that  there  is  no  material  exposure  to  interest  rate  risk  arising  from  our  investments.  Fixed  rate 
investments  and  borrowings  may  have  their  fair  market  value  adversely  impacted  from  changes  in  interest  rates.  At  December 31, 
2015,  we  do  not  hold  any  material  asset-backed  investment  securities  and  in  2015,  we  did  not  realize  any  losses  related  to  asset-
backed  investment  securities.  Based  upon  our  overall  interest  rate  exposure  as  of  December 31,  2015,  a  change  of  10 percent  in 
interest rates, assuming the amount of our investment portfolio and overall economic environment remains constant, would not have a 
material effect on interest income.  

The primary objective of our investment activities is to preserve the principal while at the same time maximizing yields without 
significantly  increasing  the  risk.  To  achieve  this  objective,  we  maintain  our  portfolio  of  cash  equivalents  and  investments  in 
instruments that meet high credit quality standards, as specified in our investment policy. None of our investments are held for trading 
purposes. Our policy also limits the amount of credit exposure to any one issue, issuer and type of instrument.  

As  of  December 31,  2015,  the  stated  maturities  of  our  available-for-sale  securities  are  $265.3 million  within  one  year  and 
$112.3 million from one to two years. These investments are recorded on the balance sheet at fair market value with unrealized gains 
or losses reported as a separate component of accumulated other comprehensive income (loss).  

Market Price Sensitive Instruments 

In order to reduce the potential equity dilution, we entered into the aforementioned 2017 Hedge in connection with the issuance 
of  the  2017 Notes  entitling us  to purchase  our  common  stock.  Upon  conversion  of  the  2017 Notes,  the  2017 Hedge  is  expected  to 
reduce the equity dilution if the daily volume-weighted average price per share of our common stock exceeds the strike price of the 
2017 Hedge. We also entered into warrant transactions with the counterparties of the 2017 Hedge entitling them to acquire shares of 
our common stock. The warrant transaction could have a dilutive effect on our earnings per share to the extent that the price of our 
common stock during a given measurement period (the quarter or year to date period) exceeds the strike price of the warrants. See 
Note 6 to the Consolidated Financial Statements included in this Annual Report for further discussion.  

Foreign Currency Exchange Risk 

A substantial portion of our operations are located in the United States, and the majority of our sales since inception have been 
made in the United States dollars. Accordingly, we have assessed that we do not have any material exposure to foreign currency rate 
fluctuations. However, as our business in markets outside of the United States continues to increase, we will be exposed to foreign 
currency exchange risk related to our foreign operations. Fluctuations in the rate of exchange between the United States dollar and 
foreign currencies, primarily the pound sterling the euro, the Australian dollar and the yen, could adversely affect our financial results, 
including our revenues, revenue growth rates, gross margins, income and losses as well as assets and liabilities. In addition, loss of 
financial  stability  within  these  markets  could  lead  to  delays  in  reimbursement  or  inability  to  remit  payment  due  to  currency 
controls.  Specifically, we have operations in Puerto Rico, Greece, Argentina and Venezuela that have financial instability or currency 
controls. We do not have any material financial exposure to one customer or one country that would significantly hinder our liquidity.   

55 

 
 
We translate the financial statements of our foreign subsidiaries with functional currencies other than the United States dollar 
into the United States dollar for consolidation using end-of-period exchange rates for assets and liabilities and average exchange rates 
during each reporting period for results of operations. Net gains or losses resulting from the translation of foreign financial statements 
and the effect of exchange rate changes on intercompany receivables and payables of a long-term investment nature are recorded as a 
separate component of stockholders’ equity. These adjustments will affect net income only upon sale or liquidation of the underlying 
investment in foreign subsidiaries. Exchange rate fluctuations resulting from the translation of the short-term intercompany balances 
between domestic entities and our foreign subsidiaries are recorded as foreign currency transaction gains or losses and are included in 
other income (expense) in the consolidated statement of operations.  For those short-term intercompany balances, we enter into the 
foreign currency forward contracts to partially offset the impact from fluctuation of the foreign currency rates. The notional amount of 
the  outstanding  foreign  currency  forward contracts  was $8.5  million  as  of December  31,  2015,  which  was  settled  in  January  2016. 
During the year ended December 31, 2015, a gain of $1.7 million was recognized in other income due to the change in the fair value 
of the derivative instruments, and the fair value of the hedge contracts we held was immaterial on our Consolidated Balance Sheet as 
of December 31, 2015. The notional principal amounts provide one measure of the transaction volume outstanding as of period end, 
but do not represent the amount of our exposure to market loss. The estimates of fair value are based on applicable and commonly 
used pricing models using prevailing financial market information. The amounts ultimately realized upon settlement of these financial 
instruments,  together  with  the  gains  and  losses  on  the  underlying  exposures,  will  depend  on  actual  market  conditions  during  the 
remaining  life  of  the  instruments.    The  financial  exposures  by  exchange  rate  fluctuations  are  monitored  and  managed  by  us  as  an 
integral part of our overall risk management program, which recognizes the unpredictability of financial markets and seeks to reduce 
potentially adverse effects on our results. We expect the exposure on the foreign currency rate fluctuations to our financial results will 
be immaterial for the foreseeable future.  

Item 8. 

Financial Statements and Supplementary Data  

The  consolidated  financial  statements  and  supplementary  data  required  by  this  item  are  set  forth  at  the  pages  indicated  in 

Item 15.  

Item 9. 

Changes in and Disagreements with Accountants on Accounting and Financial Disclosure 

None.  

Item 9A.  Controls and Procedures  

Disclosure Controls and Procedures 

We  maintain  disclosure  controls  and  procedures  that  are  designed  to  ensure  that  information  required  to  be  disclosed  in  our 
reports  under  the  Securities  Exchange  Act  of  1934,  as  amended  (Exchange  Act)  is  recorded,  processed,  summarized  and  reported 
within the timelines specified in the Commission’s rules and forms, and that such information is accumulated and communicated to 
our  management,  including  our  Chief  Executive  Officer  and  Chief  Financial  Officer,  as  appropriate,  to  allow  timely  decisions 
regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognized that any 
controls and procedures, no matter how well designed and operated, can only provide reasonable assurance of achieving the desired 
control  objectives,  and  in  reaching  a  reasonable  level  of  assurance,  management  necessarily  was  required  to  apply  its  judgment  in 
evaluating the cost-benefit relationship of possible controls and procedures.  

Under  the  supervision  and  with  the  participation  of  our  management,  including  our  Chief  Executive  Officer  and  our  Chief 
Financial Officer, we carried out an evaluation of the effectiveness of the Company’s disclosure controls and procedures (as defined in 
SEC Rules 13a — 15(e) and 15d — 15(e) of the Exchange Act) as of December 31, 2015. Based on such evaluation, our management 
has concluded as of December 31, 2015, the Company’s disclosure controls and procedures are effective.  

Management’s Report on Internal Control over Financial Reporting 

Our management is responsible for establishing and maintaining adequate internal control over financial reporting as defined in 
Rule 13a-15(f)  under  the  Exchange  Act.  Internal  control  over  financial  reporting  refers  to  the  process  designed  by,  or  under  the 
supervision of, our Chief Executive Officer and Chief Financial Officer, and effected by our board of directors, management and other 
personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements 
for external purposes in accordance with U.S. generally accepted accounting principles.  

Management has used the framework set forth in the report entitled Internal Control — Integrated Framework published by the 
Committee  of  Sponsoring  Organizations  of  the  Treadway  Commission  (2013  framework)  to  evaluate  the  effectiveness  of  the 
Company’s internal control over financial reporting. On May 14, 2013, the Committee of Sponsoring Organizations of the Treadway 
Commission  published  a  2013  framework  and  related  illustrative  documents.  We  adopted  the  new  framework during  2014. 
Management has concluded that the Company’s internal control over financial reporting was effective as of December 31, 2015, based 
on those criteria. Ernst & Young LLP, the Company’s independent registered public accounting firm, has issued an attestation report 
on the Company’s internal control over financial reporting which is included herein.  

56 

 
 
Changes in Internal Control over Financial Reporting 

We are involved in ongoing evaluations of internal controls. In anticipation of the filing of this Form 10-K, our Chief Executive 
Officer and Chief Financial Officer, with the assistance of other members of our management, performed an evaluation of any change 
in  internal  control  over  financial  reporting  that  occurred  during  our  last  fiscal  quarter  that  has  materially  affected,  or  is  likely  to 
materially  affect,  our  internal  controls  over  financial  reporting.  There  has  been  no  change  to  our  internal  control  over  financial 
reporting  during  our  most  recent  fiscal  quarter  that  has  materially  affected,  or  is reasonably  likely  to  materially  affect,  our  internal 
control over financial reporting.  

57 

 
 
 
 
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM 

The Board of Directors and Stockholders of NuVasive, Inc. 

We  have  audited  NuVasive,  Inc.’s  internal  control  over  financial  reporting  as  of  December 31,  2015,  based  on  criteria 
established  in  Internal  Control—Integrated  Framework  issued  by  the  Committee  of  Sponsoring  Organizations  of  the  Treadway 
Commission  (2013  framework)  (the  COSO  criteria).  NuVasive, Inc.’s  management  is  responsible  for maintaining  effective  internal 
control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting included in the 
accompanying management’s Report on Internal Control over Financial Reporting. Our responsibility is to express an opinion on the 
company’s internal control over financial reporting based on our audit. 

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). 
Those  standards  require  that  we  plan  and  perform  the  audit  to  obtain  reasonable  assurance  about  whether  effective  internal  control 
over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over 
financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of 
internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. 
We believe that our audit provides a reasonable basis for our opinion. 

A  company’s  internal  control  over  financial  reporting  is  a  process  designed  to  provide  reasonable  assurance  regarding  the 
reliability  of  financial  reporting  and  the  preparation  of  financial  statements  for  external  purposes  in  accordance  with  generally 
accepted  accounting  principles.  A  company’s  internal  control  over  financial  reporting  includes  those  policies  and  procedures  that 
(1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the 
assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial 
statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being 
made  only  in  accordance  with  authorizations  of  management  and  directors  of  the  company;  and  (3) provide  reasonable  assurance 
regarding  prevention  or  timely  detection  of  unauthorized  acquisition,  use,  or  disposition  of  the  company’s  assets  that  could  have  a 
material effect on the financial statements. 

Because  of  its  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect  misstatements.  Also, 
projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of 
changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate. 

In  our  opinion,  NuVasive,  Inc.  maintained,  in  all  material  respects,  effective  internal  control  over  financial  reporting  as  of 

December 31, 2015, based on the COSO criteria. 

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the 
consolidated  balance  sheets  of  NuVasive,  Inc.  as  of  December 31,  2015  and  2014,  and  the  related  consolidated  statements  of 
operations, comprehensive income (loss), equity, and cash flows for each of the three years in the period ended December 31, 2015 of 
NuVasive, Inc. and our report dated February 11, 2016 expressed an unqualified opinion thereon. 

/s/ Ernst & Young LLP 

San Diego, California 
February 11, 2016 

58 

 
 
 
 
 
Item 9B.  Other Information 

None.  

PART III  

Certain information required by Part III is omitted from this report because the Company will file a definitive proxy statement 
within  120 days  after  the  end  of  its  fiscal  year  pursuant  to  Regulation 14A  (the  Proxy  Statement)  for  its  2016  annual  meeting  of 
stockholders, and certain information included in the Proxy Statement is incorporated herein by reference.  

Item 10.  Directors, Executive Officers and Corporate Governance  

We have adopted a Code of Ethical Business Conduct for all officers, directors and shareowners. The Code of Ethical Business 
Conduct is available on our website, www.nuvasive.com. We intend to disclose future amendments to, or waivers from, provisions of 
our Code of Ethical Business Conduct that apply to our Principal Executive Officer, Principal Financial Officer, Principal Accounting 
Officer, or Controller, or persons performing similar functions, within four business days of such amendment or waiver.  

The  other  information  required  by  this  Item 10  will  be  set  forth  in  the  Proxy  Statement  and  is  incorporated  in  this  report  by 

reference.  

Item 11.  Executive Compensation 

The information required by this item will be set forth in the Proxy Statement and is incorporated in this report by reference.  

Item 12.  Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters 

The information required by this item will be set forth in the Proxy Statement and is incorporated in this report by reference.  

Item  13.  Certain Relationships and Related Transactions, and Director Independence 

The information required by this item will be set forth in the Proxy Statement and is incorporated in this report by reference.  

Item  14.  Principal Accounting Fees and Services 

The information required by this item will be set forth in the Proxy Statement and is incorporated in this report by reference.  

PART IV  

Item  15.  Exhibits, Financial Statement Schedules 

(a)  The following documents are filed as a part of this report:  

(1)  Report of Independent Registered Public Accounting Firm  

Consolidated Balance Sheets as of December 31, 2015 and 2014  

Consolidated Statements of Operations for the years ended December 31, 2015, 2014 and 2013  

Consolidated Statements of Comprehensive Income (Loss) for the years ended December 31, 2015, 2014 and 2013  

Consolidated Statements of Equity for the years ended December 31, 2015, 2014 and 2013  

Consolidated Statements of Cash Flows for the years ended December 31, 2015, 2014 and 2013 

Notes to Consolidated Financial Statements  

(2)  Financial Statement Schedules: Schedule II — Valuation Accounts  

All  other  financial  statement  schedules  have  been  omitted  because  they  are  not  applicable,  not  required  or  the 
information required by such schedules is shown in the financial statements or the notes thereto.  

59 

 
 
 
 
 
 
 
 
 
 
 
 
 
(2) 

Exhibits 

See Item 15, subsection (b) below. 

(b) The following exhibits are filed as part of this report:  

Exhibit  
Number 

3.1 

3.2 

3.3 

3.4 

4.1 

4.2 

4.3 

4.4 

10.1# 

10.2# 

10.3# 

10.4# 

10.5# 

10.6# 

10.7# 

10.8# 

10.9# 

Description

Restated Certificate of Incorporation (incorporated by reference to our Quarterly Report on Form 10-Q filed with the 
Commission on August 13, 2004) 

Certificate of Amendment to the Restated Certificate of Incorporation (incorporated by reference to our Current Report
on Form 8-K filed with the Commission on September 28, 2011) 

Restated  Bylaws  (incorporated  by  reference  to  our  Current  Report  on  Form 8-K  filed  with  the  Commission  on
January 6, 2012) 

Amendment No. 1 to the Restated Bylaws (incorporated by reference to our Current Report on Form 8-K filed with the 
Commission on May 19, 2014) 

Specimen  Common  Stock  Certificate  (incorporated  by  reference  to  our  Annual  Report  on  Form 10-K  filed  with  the 
Commission on March 16, 2006) 

Certificate  of  Designations  of  Series A  Participating  Preferred  Stock  filed  with  the  Delaware  Secretary  of  State  on
June 28, 2011 (incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 
2011) 

Indenture dated June 28, 2011 between the Company and U.S. National Association (incorporated by reference to our
Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Form of 2.75% Convertible Senior Note due 2017 (incorporated by reference to our Current Report on Form 8-K filed 
with the Commission on June 29, 2011) 

2004 Amended and Restated Equity Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q 
filed with the Commission on July 26, 2012) 

Amendment No. 1 to the 2004 Amended and Restated Equity Incentive Plan (incorporated by reference to our Annual
Report on Form 10-K filed with the Commission on March 3, 2014) 

Form  of  Stock  Option  Award  Notice  under  the  2004  Amended  and  Restated  Equity  Incentive  Plan  (incorporated  by
reference to Amendment No. 1 to our Registration Statement on Form S-1 filed with the Commission on April 8, 2004)

Form of Option Exercise and Stock Purchase Agreement under the 2004 Amended and Restated Equity Incentive Plan 
(incorporated by reference to Amendment No. 1 to our Registration Statement on Form S-1 filed with the Commission 
on April 8, 2004) 

Form  of  Restricted  Stock  Unit  Award  Agreement  under  the  2004  Amended  and  Restated  Equity  Incentive  Plan 
(incorporated by reference to our Annual Report on Form 10-K filed with the Commission on February 26, 2010) 

Form of Restricted Stock Grant Notice and Restricted Stock Agreement under the 2004 Amended and Restated Equity
Incentive Plan (incorporated by reference to Amendment No.1 to our Registration Statement on Form S-1 filed with the 
Commission on April 8, 2004) 

NuVasive,  Inc.  2004  Amended  and  Restated  Employee  Stock  Purchase  Plan  (incorporated  by  reference  to  our
Quarterly Report on Form 10-Q filed with the Commission on October 30, 2014) 

2014  Equity  Incentive  Plan (incorporated by  reference  to  Exhibit A  to  our  Definitive  Proxy  Statement  filed with the
Commission on March 27, 2014) 

Form  of  Performance  Restricted  Stock  Unit  Agreement  (with  accompanying  Form  Notice  of  Grant)  under  the  2014
Equity Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on
May 4, 2015) 

10.10# 

Form of Executive Restricted Stock Unit Agreement (with accompanying Form Notice of Grant) under the 2014 Equity
Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on May 4, 
2015) 

60 

 
 
  
 
   
 
 
 
  
 
 
  
 
 
  
 
 
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
   
 
 
 
 
 
Exhibit  
Number 

10.11# 

10.12# 

10.13# 

10.14# 

10.15# 

10.16# 

10.17# 

10.18# 

10.19# 

10.20# 

10.21# 

10.22# 

10.23# 

10.24# 

Description

Form  of  Performance  Cash  Award  Agreement  (with  accompanying  Form  Notice  of  Grant)  under  the  2014  Equity
Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on May 4, 
2015) 

Form of Performance Restricted Stock Unit Agreement (with accompanying Notice of Grant) for grants after February
11, 2016 under the 2014 Equity Incentive Plan 

Form  of  Executive  Restricted  Stock  Unit  Agreement  (with  accompanying  Form  Notice  of  Grant)  for  grants  after
February 11, 2016 under the 2014 Equity Incentive Plan 

Form of Performance Cash Award Agreement (with accompanying Form Notice of Grant) for grants after February 11,
2016 under the 2014 Equity Incentive Plan 

NuVasive, Inc. 2014 Executive Incentive Compensation Plan (incorporated by reference to Exhibit B to our Definitive
Proxy Statement filed with the Commission on March 27, 2014) 

Form  of  Indemnification  Agreement  between  the  Company  and  its  directors  and  certain  executives  thereof
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on May 19, 2014) 

NuVasive, Inc. Amended and Restated Executive Severance Plan (incorporated by reference to our Current Report on
Form 8-K filed with the Commission on August 6, 2015) 

Form of Change in Control Agreement between the Company and certain executives thereof (incorporated by reference
to our Current Report on Form 8-K filed with the Commission on May 19, 2014) 

NuVasive, Inc. Deferred Compensation Plan (incorporated by reference to our Current Report on Form 8-K filed with 
the Commission on August 6, 2015) 

Separation Agreement and Release dated March 27, 2015 between the Company and Alex V. Lukianov (incorporated 
by reference to our Current Report on Form 8-K filed with the Commission on April 1, 2015) 

Consulting Agreement dated March 27, 2015 between the Company and Alex V. Lukianov (incorporated by reference
to our Current Report on Form 8-K filed with the Commission on April 1, 2015) 

Letter Agreement dated May 22, 2015 between the Company and Gregory T. Lucier (incorporated by reference to our
Current Report on Form 8-K filed with the Commission on May 26, 2015) 

Notice  of  Grant  of  Share  Purchase  Matching  Performance  Restricted  Stock  Units  and  Award  Agreement  granted  to
Gregory  T.  Lucier  on  May  22,  2015  (incorporated  by  reference  to  our  Current  Report  on  Form  8-K  filed  with  the 
Commission on May 26, 2015) 

Notice  of  Grant  of  “Inducement”  Performance  Restricted  Stock  Units  and  Award  Agreement  granted  to  Gregory  T.
Lucier on May 22, 2015 (incorporated by reference to our Current Report on Form 8-K filed with the Commission on
May 26, 2015) 

10.25# 

Non-Employee Director Cash Compensation Plan (incorporated by reference to our Annual Report on Form 10-K filed 
with the Commission on March 3, 2014) 

10.26 

10.27 

10.28 

10.29 

Lease  Agreement  for  Sorrento  Summit  dated  November 6,  2007  between  the  Company  and  HCPI/Sorrento,  LLC 
(incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on November 8, 2007) 

Confirmation for base call option transaction dated June 22, 2011 between the Company and Bank of America, N.A.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for additional call option transaction dated June 24, 2011, between the Company and Bank of America,
N.A. (incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for base call option transaction dated June 22, 2011 between the Company and Goldman, Sachs & Co.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

61 

 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
  
  
 
 
  
 
 
  
 
 
   
 
 
   
 
 
  
 
 
  
 
 
  
 
 
   
  
 
   
 
 
   
 
 
  
 
 
  
 
 
  
 
 
  
 
 
 
   
 
Exhibit  
Number 

10.30 

10.31 

10.32 

10.33 

10.34 

10.35 

10.36† 

10.37† 

10.38† 

21.1 

23.1 

31.1 

31.2 

32.1* 

Description

Confirmation for additional call option transaction dated June 24, 2011 between the Company and Goldman, Sachs &
Co. (incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation  for  base  warrant  transaction  dated  June 22,  2011  between  the  Company  and  Bank  of  America,  N.A.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for additional warrant transaction dated June 24, 2011 between the Company and Bank of America, N.A. 
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation  for  base  warrant  transaction  dated  June 22,  2011  between  the  Company  and  Goldman,  Sachs  &  Co.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for additional warrant transaction dated June 24, 2011 between the Company and Goldman, Sachs & Co. 
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Preferred Stock Purchase Agreement dated January 13, 2009 among the Company, Progentix Orthobiology, B.V. and
the sellers listed on Schedule A thereto (incorporated by reference to our Annual Report on Form 10-K filed with the 
Commission on February 26, 2010) 

Option Purchase Agreement dated January 13, 2009 among the Company, Progentix Orthobiology, B.V. and the sellers 
listed on Schedule A thereto (incorporated by reference to our Annual Report on Form 10-K filed with the Commission 
on February 26, 2010) 

Exclusive  Distribution  Agreement  dated  January 13,  2009  between  the  Company  and  Progentix  Orthobiology,  B.V.
(incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on May 8, 2009) 

Settlement and License Agreement dated April 25, 2013 among the Company, Medtronic Sofamor Danek USA, Inc.,
Warsaw Orthopedic, Inc., Medtronic Puerto Rico Operations Co. and Medtronic Sofamor Danek Deggendorf, GmbH
(incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on July 30, 2013) 

List of subsidiaries of the Company 

Consent of Independent Registered Public Accounting Firm 

Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 
1934, as amended 

Certification  of  Chief  Financial  Officer  pursuant  to  Rule 13a-14(a)  and  15d-14(a)  of  the  Securities  Exchange  Act  of 
1934, as amended 

Certifications of the Chief Executive Officer and Chief Financial Officer pursuant to Rule 13a-14(b) of the Securities 
Exchange Act of 1934, as amended, and 18 U.S.C. section 1350 

101 

101 

101 

101 

101 

101 

† 

# 
* 

XBRL Instance Document 

XBRL Taxonomy Extension Schema Document 

XBRL Taxonomy Calculation Linkbase Document 

XBRL Taxonomy Label Linkbase Document 

XBRL Taxonomy Presentation Linkbase Document 

XBRL Taxonomy Definition Linkbase Document 

Certain confidential information contained in this exhibit was omitted by means of redacting a portion of the text and replacing 
it with an asterisk. We have filed separately with the Commission an unredacted copy of the exhibit.  
Indicates management contract or compensatory plan.  
These certifications are being furnished solely to accompany this annual report pursuant to 18 U.S.C. Section 1350, and are not 
being filed for purposes of Section 18 of the Securities Exchange Act of 1934 and are not to be incorporated by reference into 
any filing of NuVasive, Inc., whether made before or after the date hereof, regardless of any general incorporation language in 
such filing. 

62 

 
 
 
   
 
 
 
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
   
 
 
  
 
 
  
 
 
  
 
 
 
  
 
  
 
 
  
 
 
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this 

report to be signed on its behalf by the undersigned, thereunto duly authorized.  

SIGNATURES  

Date: February 11, 2016 

Date: February 11, 2016 

    NUVASIVE, INC.

By: /s/ Gregory T. Lucier 
Gregory T. Lucier  
Chairman and Chief Executive Officer 
(Principal Executive Officer) 

By: /s/ Quentin S. Blackford 
Quentin S. Blackford 
Executive Vice President and 
Chief Financial Officer 
(Principal Financial Officer) 

63 

 
 
 
 
 
   
 
 
   
   
 
 
   
 
 
POWER OF ATTORNEY  

KNOW  ALL  PERSONS  BY  THESE  PRESENTS,  that  each  person  whose  signature  appears  below  constitutes  and  appoints 
Gregory T. Lucier and Quentin S. Blackford, jointly and severally, his or her attorneys-in-fact, each with the power of substitution, for 
him or her in any and all capacities, to sign any amendments to this Report on Form 10-K, and to file the same, with exhibits thereto 
and other documents in connection therewith with the Securities and Exchange Commission, hereby ratifying and confirming all that 
each of said attorneys-in-fact, or his or her substitute or substitutes may do or cause to be done by virtue hereof.  

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons 

on behalf of the registrant and in the capacities and on the dates indicated.  

Signature 

Title 

Date

/s/    Gregory T. Lucier 

Gregory T. Lucier 

Chairman and Chief Executive Officer 
(Principal Executive Officer) 

February 11, 2016 

/s/    Quentin S. Blackford 

Quentin S. Blackford 

/s/    Jack R. Blair 

Jack R. Blair 

/s/    Vickie L. Capps 

Vickie L. Capps 

/s/    Peter C. Farrell, Ph.D, AM 

Peter C. Farrell, Ph.D, AM 

/s/    Lesley H. Howe 

Lesley H. Howe 

/s/    Leslie V. Norwalk, Esq.  

Leslie V. Norwalk, Esq. 

/s/    Daniel J. Wolterman 

Daniel J. Wolterman 

February 11, 2016 

February 11, 2016 

February, 11 2016 

February 11, 2016 

February 11, 2016 

February 11, 2016 

February 11, 2016 

Executive Vice President and Chief 
Financial Officer (Principal Financial and 
Accounting Officer) 

Director 

Director 

Director 

Director 

Director 

Director 

64 

 
 
 
  
 
   
 
 
  
 
 
 
 
 
  
 
 
 
 
  
 
 
 
   
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
  
 
 
 
   
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
  
 
 
NUVASIVE, INC.  

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS  

Report of Independent Registered Public Accounting Firm ..............................................................................................................     66
Consolidated Balance Sheets as of December 31, 2015 and 2014 .....................................................................................................     67
Consolidated Statements of Operations for the years ended December 31, 2015, 2014 and 2013 ....................................................     68
Consolidated Statements of Comprehensive Income (Loss) for the years ended December 31, 2015, 2014 and 2013 .....................     69
Consolidated Statements of Equity for the years ended December 31, 2015, 2014 and 2013 ...........................................................     70
Consolidated Statements of Cash Flows for the years ended December 31, 2015, 2014 and 2013 ...................................................     71
Notes to Consolidated Financial Statements ......................................................................................................................................     72

65 

 
 
 
 
 
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM  

The Board of Directors and Stockholders of NuVasive, Inc. 

We have audited the accompanying consolidated balance sheets of NuVasive, Inc. as of December 31, 2015 and 2014, and the 
related consolidated statements of operations, comprehensive income (loss), equity, and cash flows for each of the three years in the 
period ended December 31, 2015. Our audits also included the financial statement schedule listed in the Index at Item 15(a). These 
financial statements and schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on 
these financial statements and schedule based on our audits. 

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). 
Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are 
free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the 
financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, 
as  well  as  evaluating  the  overall  financial  statement  presentation.  We  believe  that  our  audits  provide  a  reasonable  basis  for  our 
opinion. 

In  our  opinion,  the  financial  statements  referred  to  above  present  fairly,  in  all  material  respects,  the  consolidated  financial 
position of NuVasive, Inc. at December 31, 2015 and 2014, and the consolidated results of its operations and its cash flows for each of 
the three years in the period ended December 31, 2015, in conformity with U.S. generally accepted accounting principles. Also, in our 
opinion,  the  related  financial  statement  schedule,  when  considered  in  relation  to  the  basic  financial  statements  taken  as  a  whole, 
presents fairly in all material respects the information set forth therein. 

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), 
NuVasive, Inc.’s internal control over financial reporting as of December 31, 2015, based on criteria established in Internal Control — 
Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) and our 
report dated February 11, 2016 expressed an unqualified opinion thereon. 

/s/ Ernst & Young LLP 

San Diego, California 
February 11, 2016 

66 

 
 
 
 
NUVASIVE, INC.  

CONSOLIDATED BALANCE SHEETS  

(In thousands, except par value and shares)  

Current assets: 

ASSETS 

Cash and cash equivalents 
Short-term marketable securities 
Accounts receivable, net of allowances of $5,320 and $5,844, respectively 
Inventory, net 
Prepaid income taxes 
Prepaid expenses and other current assets 

Total current assets 

Property and equipment, net 
Long-term marketable securities 
Intangible assets, net 
Goodwill 
Deferred tax assets, non-current 
Restricted cash and investments 
Other assets 

Total assets 

LIABILITIES AND EQUITY 

Current liabilities: 

Accounts payable and accrued liabilities 
Accrued payroll and related expenses 
Litigation liabilities 
Income tax liabilities 

Total current liabilities 

Senior convertible notes 
Deferred and income tax liabilities, non-current 
Non-current litigation liabilities 
Other long-term liabilities 
Commitments and contingencies 
Stockholders’ equity: 

Preferred stock, $0.001 par value; 5,000,000 shares authorized, none outstanding 
Common stock, $0.001 par value; 120,000,000 shares authorized at December 31, 2015 
and 2014, respectively, 52,616,471 and 47,691,744 issued and outstanding at 
December 31, 2015 and 2014, respectively 
Additional paid-in capital 
Accumulated other comprehensive loss 
Accumulated deficit 
Treasury stock at cost; 3,316,794 shares and 233,369 shares at December 31, 2015 and 
December 31, 2014, respectively 

Total NuVasive, Inc. stockholders’ equity 

Non-controlling interests 
Total equity 
Total liabilities and equity 

December 31, 

2015 

2014 

192,339    $
165,423   
127,595   
168,140   
40,540   
8,790   
702,827   
141,441   
112,332   
85,076   
154,281   
67,051   
5,615   
21,026   
1,289,649    $

60,986    $
37,641   
—   
990   
99,617   
376,542   
8,602   
88,261   
14,425   

142,387 
220,329 
118,959 
154,638 
11,321 
10,325 
657,959 
128,565 
43,042 
96,555 
154,443 
111,354 
123,233 
26,420 
1,341,571 

133,324 
38,032 
30,000 
12,740 
214,096 
360,746 
11,441 
93,700 
13,230 

—   

— 

53   
989,387   
(12,112 ) 
(120,647 ) 

(161,788 ) 
694,893   

7,309    $
702,202    $
1,289,649    $

48 
847,145 
(9,670)
(186,938)

(10,537)
640,048 
8,310 
648,358 
1,341,571   

   $

   $

   $

   $
   $
   $

See accompanying notes to Consolidated Financial Statements.  

67 

 
 
  
  
  
 
  
  
  
 
 
    
  
      
  
 
       
         
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
   
 
 
    
   
 
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
    
   
 
 
    
   
 
 
    
 
    
 
    
 
    
 
    
 
    
 
    
 
  
 
NUVASIVE, INC.  

CONSOLIDATED STATEMENTS OF OPERATIONS  

(In thousands, except per share amounts)  

Revenue 
Cost of goods sold (excluding below amortization of intangible assets) 

   $

Gross profit 
Operating expenses: 

   Sales, marketing and administrative 
   Research and development 
   Amortization of intangible assets 
   Impairment of intangible assets 
   Litigation liability (gain) loss 
   Business transition costs 

Total operating expenses 
Interest and other expense, net: 

   Interest income 
   Interest expense 
   Other income (expense), net 

Total interest and other expense, net 
Income (loss) before income taxes 

Income tax expense 

Consolidated net income (loss) 

Add back net loss attributable to non-controlling interests 

Net income (loss) attributable to NuVasive, Inc. 

Net income (loss) per share attributable to NuVasive, Inc.: 

   Basic 
   Diluted 

Weighted average shares outstanding: 

   Basic 
   Diluted 

   $
   $
   $

   $
   $

2015 

Year Ended December 31, 
2014 

2013 

 $ 

811,113 
194,479 
616,634 

$

762,415 
182,358 
580,057 

464,530 
35,851 
12,516 
— 
(41,826)
6,480 
477,551 

1,589 
(29,078)
425 
(27,064)
112,019 
(46,729)
65,290 
(1,001)
66,291 

1.36 
1.26 

48,687 
52,424 

 $ 
 $ 
 $ 

 $ 
 $ 

468,285 
37,986 
13,571 
10,708 
30,000 
1,363 
561,913 

968 
(27,911)
(2,411)
(29,354)
(11,210)
(6,286)
(17,496) $
(776) $
(16,720) $

(0.36) $
(0.36) $

46,715 
46,715 

685,173 
180,484 
504,689 

420,064 
32,209 
19,326 
— 
— 
— 
471,599 

755 
(27,178)
3,101 
(23,322)
9,768 
(2,783)
6,985 
(917)
7,902 

0.18 
0.17 

44,461 
46,786   

See accompanying notes to Consolidated Financial Statements.  

68 

 
 
  
  
  
 
  
  
    
 
 
 
    
   
 
    
   
 
    
 
   
 
 
 
    
   
 
    
   
 
    
   
 
    
   
 
    
   
 
    
   
 
    
   
 
    
 
   
 
 
 
    
   
 
    
   
 
    
   
 
    
   
 
    
   
 
    
   
 
  
    
 
   
 
 
 
    
 
   
 
 
 
    
 
   
 
 
 
    
   
 
    
   
 
 
 
CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)  

NUVASIVE, INC. 

(In thousands)  

Consolidated net income (loss) 

Other comprehensive loss: 

Unrealized loss on marketable securities, net of tax 
Translation adjustments, net of tax 
Other comprehensive loss: 

Total consolidated comprehensive income (loss) 

Net loss attributable to non-controlling interests 

Comprehensive income (loss) attributable to NuVasive, Inc. 

   $

2015 

Year Ended December 31, 
2014 

2013 

   $

65,290 

 $ 

(17,496) $

6,985 

(344)
(2,098)
(2,442)
62,848 
1,001 
63,849 

 $ 

(161)
(6,271)
(6,432)
(23,928)
776 
(23,152) $

(27)
(3,997)
(4,024)
2,961 
917 
3,878   

See accompanying notes to Consolidated Financial Statements.  

69 

 
 
  
  
  
 
  
  
    
 
 
 
    
 
   
 
 
 
    
   
 
    
   
 
    
   
 
    
   
 
    
   
 
 
 
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7

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
NUVASIVE, INC.  
CONSOLIDATED STATEMENTS OF CASH FLOWS  

(In thousands)  

2015 

Year Ended December 31, 
2014 

2013 

   $

65,290     $ 

(17,496)    $

6,985 

Operating activities: 

Consolidated net income (loss) 
Adjustments to reconcile net income (loss) to net cash provided by operating 
activities: 

Depreciation and amortization 
Deferred income tax expense (benefit) 
Amortization of non-cash interest 
Stock-based compensation 
Impairment of intangible assets 
Reserves on current assets 
Other non-cash adjustments 
Changes in operating assets and liabilities, net of effects from acquisitions: 

Accounts receivable 
Inventory 
Prepaid expenses and other current assets 
Accounts payable and accrued liabilities 
Accrued payroll and related expenses 
Accrued royalties 
Litigation liability 
Income taxes 

Net cash provided by operating activities 

Investing activities: 

Acquisitions and other investments 
Purchases of intangible assets 
Proceeds from sales of property and equipment 
Purchases of property and equipment 
Purchases of marketable securities 
Proceeds from marketable securities 
Purchases of restricted investments 
Proceeds from restricted investments 

Financing activities: 

Net cash used in investing activities 

Principal payment of 2013 Senior Convertible Notes 
Incremental tax benefits related to stock-based compensation awards 
Proceeds from the issuance of common stock 
Payment of contingent consideration 
Purchase of treasury stock 
Other financing activities 

Net cash (used in) provided by financing activities 

Effect of exchange rate changes on cash 

Increase (decrease) in cash and cash equivalents 

Cash and cash equivalents at beginning of year 
Cash and cash equivalents at end of year 

Supplemental disclosure of non-cash transactions: 

Intangible asset purchase 
Issuance of common stock for contingent consideration and asset acquisitions 

Supplemental cash flow information: 

Interest paid 
Income taxes paid 

   $

   $
   $

   $
   $

65,915       
34,757       
17,851       
26,203       
—       
9,454       
17,581       

(9,463)      
(25,984)      
1,239       
7,742       
(192)      
(46,092)      
(36,270)      
(39,304)      
88,727       

(1,357)      
(32,020)      
40       
(75,772)      
(427,945)      
411,471       
(62,625)      
180,694       
(7,514)      

—       
15,185       
12,106       
(514)      
(56,929)      
(192)      
(30,344)      
(917)      
49,952       
142,387       
192,339     $ 

—     $ 
—     $ 

11,069     $ 
36,303     $ 

65,837      
(23,231)     
16,490      
33,687      
10,708      
1,856      
13,191      

(18,465)     
(21,343)     
(5,183)     
5,855      
7,179      
12,410      
30,000      
4,053      
115,548      

(500)     
—      
241      
(58,424)     
(217,158)     
174,816      
(3,800)     
—      
(104,825)     

—      
11,896      
23,354      
(498)     
(3,782)     
(693)     
30,277      
(1,438)     
39,562      
102,825      
142,387     $

27,389     $
3,161     $

11,069     $
13,640     $

63,106 
(11,341)
15,336 
33,240 
— 
7,468 
7,116 

(17,384)
(21,002)
(3,608)
4,665 
3,220 
19,106 
(7,500)
(1,968)
97,439 

(2,987)
(11,831)
— 
(47,597)
(218,454)
216,299 
— 
— 
(64,570)

(74,311)
13,569 
8,422 
— 
— 
(162)
(52,482)
(861)
(20,474)
123,299 
102,825 

— 
— 

12,035 
3,196   

See accompanying notes to Consolidated Financial Statements. 

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NUVASIVE, INC.  

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS  

1.    Organization and Significant Accounting Policies  

Description of Business 

NuVasive, Inc. (the “Company” or “NuVasive”) was incorporated in Delaware on July 21, 1997, and began commercializing its 
products  in  2001.  The  Company’s  principal  product  offering  includes  a  minimally-disruptive  surgical  platform  called  Maximum 
Access Surgery, or MAS. The MAS platform combines three categories of solutions that collectively minimize soft tissue disruption 
during  spine  fusion  surgery,  provide  maximum  visualization  and  are  designed  to  enable  safe  and  reproducible  outcomes  for  the 
surgeon and the patient. The platform includes our proprietary software-driven nerve detection and avoidance systems, NVM5, and 
Intraoperative Monitoring (“IOM”), services and support; MaXcess, an integrated split-blade retractor system; and a wide variety of 
specialized implants and biologics. The Company also recently launched Integrated Global Alignment (“iGA”), in which products and 
computer assisted technology under the MAS platform help achieve more precise spinal alignment. The individual components of the 
MAS platform, and many of the Company’s products, can also be used in open or traditional spine surgery. The Company continues to 
focus  research  and development  efforts  to  expand  its  MAS product  platform  and  advance  the  applications  of  its  unique  technology 
into  procedurally-integrated  surgical  solutions.  The  Company  dedicates  significant  resources  toward  training  spine  surgeons  on  its 
unique technology and products. 

The Company’s primary business model is to loan its MAS systems to surgeons and hospitals that purchase implants, biologics and 
disposables  for  use  in  individual  procedures.  In  addition,  for  larger  customers,  the  Company’s  proprietary  nerve  monitoring  systems, 
MaXcess and surgical instrument sets are placed with hospitals for an extended period at no up-front cost to them. The Company also 
offers  a  range  of  bone  allograft  in  patented  saline  packaging,  disposables  and  spine  implants,  which  include  its  branded  CoRoent® 
products and fixation devices such as rods, plates and screws. The Company sells MAS instrument sets, MaXcess and nerve monitoring 
systems to hospitals, however, such sales are immaterial to the Company’s results of operations. 

On February 11, 2016, the Company completed the acquisition of Ellipse Technologies, Inc. (“Ellipse Technologies”). Refer to 
Note 13 to the Consolidated Financial Statements included in this Annual Report for further discussion on the acquisition of Ellipse 
Technologies. 

Basis of Presentation and Principles of Consolidation 

The accompanying consolidated financial statements include the accounts of the Company and its majority-owned or controlled 
subsidiaries,  collectively  referred  to  as  either  NuVasive  or  the  Company.  The  Company  translates  the  financial  statements  of  its 
foreign  subsidiaries  using  end-of-period  exchange  rates  for  assets  and  liabilities  and  average  exchange  rates  during  each  reporting 
period for results of operations. When there is a portion of equity in an acquired subsidiary not attributable, directly or indirectly, to 
the respective parent entity, the Company records the fair value of the non-controlling interests at the acquisition date and classifies 
the  amounts  attributable  to  non-controlling  interests  separately  in  equity  in  the  Company's  Consolidated  Financial  Statements.  Any 
subsequent  changes  in  a  parent's  ownership  interest  while  the  parent  retains  its  controlling  financial  interest  in  its  subsidiary  are 
accounted for as equity transactions. All significant intercompany balances and transactions have been eliminated in consolidation.  

Reclassification of prior period amounts to conform to current period presentation does not affect any content or total of prior 

period financial statements. 

Use of Estimates 

To prepare financial statements in conformity with generally accepted accounting principles (“GAAP”) accepted in the United 
States,  management  must  make  estimates  and  assumptions  that  affect  the  amounts  reported  in  the  financial  statements  and 
accompanying notes. Actual results could differ from those estimates.  

72 

 
 
Recent Accounting Pronouncements Not Yet Adopted 

 In May 2014, the Financial Accounting Standards Board (“FASB”) issued Accounting Standard Update No. 2014-09, Revenue 
from Contracts with Customers, (“ASU 2014-09”) an updated standard on revenue recognition. ASU 2014-09 provides enhancements 
to the quality and consistency of how revenue is reported by companies while also improving comparability in the financial statements 
of  companies  reporting  using  International  Financial  Reporting  Standards  or  GAAP. The  main  purpose  of  the  new  standard  is  for 
companies to recognize revenue to depict the transfer of goods or services to customers in amounts that reflect the consideration to 
which  a  company  expects  to  be  entitled  in  exchange  for  those  goods  or  services.  The  new  standard  also  will  result  in  enhanced 
disclosures  about  revenue,  provide  guidance  for  transactions  that  were  not  previously  addressed  comprehensively  and  improve 
guidance  for  multiple-element  arrangements. In  August  2015,  the  FASB  issued  ASU  No.  2015-14,  Revenue  from  Contracts  with 
Customers: Deferral of the Effective Date, which deferred the effective date of the new revenue standard for periods beginning after 
December 15, 2016 to December 15, 2017, with early adoption permitted but not earlier than the original effective date. Accordingly, 
the  updated  standard  is  effective  for  the  Company  in  the  first  quarter  of  fiscal  2018.  The  Company  is  evaluating  the  impact  of 
implementation  and  transition  approach  of  this  standard  on  its  financial  statements  but  does  not  anticipate  a  material  impact  on  its 
financial statements.  

In  April  2014,  the  FASB  issued  ASU  No.  2015-03  amended  requirements  that  require  debt  issuance  costs,  related  to  a 
recognized debt liability, to be presented in the balance sheet as a direct deduction from the carrying amount of that debt liability. The 
Company will apply the amended presentation requirements on January 1, 2016 and does not expect a material impact on its financial 
statements. 

Recently Adopted Accounting Standards 

On  November  20,  2015,  the  Financial  Accounting  Standards  Board  (“FASB”)  issued  ASU  No.  2015-17,  Balance  Sheet 
Classification of Deferred Taxes, requiring all deferred tax assets and liabilities, and any related valuation allowance, to be classified 
as non-current on the balance sheet. The Company elected to adopt the accounting standard in the fourth quarter of 2015 with prior 
periods in the Consolidated Financial Statements retrospectively adjusted. Upon adoption of ASU 2015-17, current deferred tax assets 
of  $22.0  million  and  current  deferred  tax  liabilities  of  $0.8  million  in  the  December  31,  2015  consolidated  balance  sheet  were 
reclassified as non-current. Additionally, current deferred tax assets of $47.9 million and current deferred tax liabilities of $0.8 million 
in the December 31, 2014 consolidated balance sheet were reclassified as non-current. 

Revenue Recognition 

 In accordance with the Securities and Exchange Commission’s guidance, the Company recognizes revenue when all four of the 
following  criteria  are  met:  (i) persuasive  evidence  that  an  arrangement  exists;  (ii) delivery  of  the  products  and/or  services  has 
occurred; (iii) the selling price is fixed or determinable; and (iv) collectability is reasonably assured. Specifically, revenue from the 
sale  of  implants,  biologics  and  disposables  is  generally  recognized  upon  acknowledgment  of  a  purchase  order  from  the  hospital 
indicating product use or implantation or upon shipment to third-party customers who immediately accept title. Revenue from the sale 
of instrument sets is recognized upon receipt of a purchase order and the subsequent shipment to customers who immediately accept 
title.  

Accounts Receivable and Related Valuation Accounts 

Accounts  receivable  in  the  accompanying  consolidated  balance  sheets  are  presented  net  of  allowances  for  doubtful  accounts. 
The  Company  performs  credit  evaluations  of  its  customers’  financial  condition  and,  generally,  requires  no  collateral  from  its 
customers. The Company makes judgments as to its ability to collect outstanding receivables and provides an allowance for specific 
receivables if and when collection becomes doubtful. Provisions are made based upon a specific review of all significant outstanding 
invoices as well as a review of the overall quality and age of those invoices not specifically reviewed. In determining the provision for 
invoices not specifically reviewed, the Company analyzes historical collection experience and current economic trends.  

In addition, the Company establishes a reserve for estimated sales returns and price adjustments that is recorded as a reduction 

to revenue. This reserve is maintained to account for the future return and price adjustments of products sold in the current period.  

Concentration of Credit Risk and Significant Customers 

Financial instruments, which potentially subject the Company to concentrations of credit risk, consist primarily of cash and cash 
equivalents, short-term and long-term marketable securities and accounts receivable. The Company limits its exposure to credit loss 
by  placing  its  cash  and  investments  with  high  credit  quality  financial  institutions.  Additionally,  the  Company  has  established 
guidelines  regarding  diversification  of  its  investments  and  their maturities,  which  are  designed  to  maintain  principal  and  maximize 
liquidity. Additionally, the Company has a diverse customer base and no single customer represented greater than ten percent of sales 
or accounts receivable for any of the periods presented.  

73 

 
 
Fair Value of Financial Instruments 

The  Company’s  financial  instruments  consist  principally  of  cash  and  cash  equivalents,  marketable  securities,  restricted 
investments, derivatives, contingent considerations, accounts receivable, accounts payable, accrued expenses, and Senior Convertible 
Notes. 

The  Company  measures  certain  assets  and  liabilities  in  accordance  with  authoritative  guidance  which  requires  fair  value 

measurements to be classified and disclosed in one of the following three categories:  

Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities.  

Level 2: Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.  

Level 3: Unobservable inputs are used when little or no market data is available.  

Assets  and  liabilities  are  classified  based  on  the  lowest  level  of  input  that  is  significant  to  the  fair  value  measurements.  The 
Company reviews the fair value hierarchy classification on a quarterly basis. Changes in the ability to observe valuation inputs may 
result  in  a  reclassification  of  levels  for  certain  assets  or  liabilities  within  the  fair  value  hierarchy.  The  Company  did  not  have  any 
transfers of assets and liabilities between the levels of the fair value measurement hierarchy during the years presented. 

Cash and Cash Equivalents 

The  Company  considers  all  highly  liquid  investments  that  are  readily  convertible  into  cash  and  have  an  original  maturity  of 

three months or less at the time of purchase to be cash equivalents.  

Marketable Securities 

The Company defines marketable securities as income yielding securities that can be readily converted into cash. Marketable 
securities consist of certificates of deposit, corporate notes, commercial paper, U.S. government treasury securities, and securities of 
government-sponsored entities.  

The Company classifies all such securities as available-for-sale as the sale of such securities may be required prior to maturity to 
implement  management  strategies.  These  securities  are  carried  at  fair  value  with  the  unrealized  gains  and  losses  reported  as  a 
component of other comprehensive income in equity until realized. Realized gains and losses and declines in value judged to be other-
than-temporary,  if  any,  on  available-for-sale  securities  are  included  in  other  income  or  expense  on  the  Consolidated  Statements  of 
Operations and a new accounting cost basis for the security is established in the period in which it occurs. The Company reviews its 
investments if there is an indicator of possible other-than-temporary impairment. Factors considered in determining whether a loss is 
other-than-temporary include the length of time and extent to which fair value has been less than the cost basis, the financial condition 
and near-term prospects of the investee, and the Company’s intent and ability to hold the investment for a period of time sufficient to 
allow  for  any  anticipated  recovery  in  market  value.  Premiums  and  discounts  are  amortized  or  accreted  over  the  life  of  the  related 
security as an adjustment to yield using the straight-line method and are included in interest income on the Consolidated Statements of 
Operations.  Interest  and  dividends  on  securities  classified  as  available-for-sale  are  also  included  in  interest  income  on  the 
Consolidated Statements of Operations. Realized gains and losses from the sale of marketable securities, if any, are determined on a 
specific identification basis. Realized gains and losses and interest income related to marketable securities were immaterial during all 
periods presented. 

The Company maintains an investment policy that requires a diversified investment portfolio in terms of types, maturities, and 
credit exposure, and invests with institutions that have high credit quality. Annually, the Company reassesses the investment policy to 
ensure it is reflective of current markets and conditions. The Company does not currently hold financial instruments for speculative 
purposes. 

Derivatives 

The  Company  maintains  a  foreign  currency  risk  management  strategy  that  uses  derivative  instruments  to  protect  against 
fluctuations in earnings and cash flows that may rise from volatility in currency exchange rates. The Company uses foreign currency 
forward  exchange  contracts  to  hedge  the  currency  exchange  rate  exposure  from  short-term  intercompany  receivables  and  payables 
denominated  in  a  currency  other  than  the  reporting  entity’s  functional  currency.  Realized  and  unrealized  gains  or  losses  forward 
contracts are included in the determination of net income as the forward contracts are not designated for hedge accounting under ASC 
Topic  815,  Derivatives  and  Hedging.  The  foreign  currency  forward  contracts  effectively  lock  in  the  exchange  rate  at  which  the 
specific  intercompany  receivables  and  payables  will  be  settled,  so  that  gains  or  losses  on  the  forward  contracts  offset  the  gains  or 
losses from changes in the value of the underlying receivables and payables. The forward contracts are generally settled monthly. 

74 

 
 
Inventory 

Inventory consists primarily of purchased finished goods, which includes specialized implants and disposables, and is stated at 
the  lower  of  cost  or  market  determined  by  utilizing  a  standard  cost  method  which  approximates  the  weighted  average  cost.  The 
Company  reviews  the  components  of  its  inventory  on  a  periodic  basis  for  excess  and  obsolescence  and  records  a  reserve  for  the 
identified items. At December 31, 2015 and 2014, the balance of the allowance for excess and obsolete inventory is $32.7 million and 
$22.6 million, respectively.  

Goodwill and Intangible Assets 

The  Company’s  goodwill  represents  the  excess  of  the  cost  over  the  fair  value  of  net  assets  acquired  from  its  business 
combinations.  The  determination  of  the  value  of  goodwill  and  intangible  assets  arising  from  business  combinations  and  asset 
acquisitions requires extensive use of accounting estimates and judgments to allocate the purchase price to the fair value of the net 
tangible  and  intangible  assets  acquired,  including  capitalized  in-process  research  and  development  (IPR&D).  Intangible  assets 
acquired  in  a  business  combination  that  are  used  for  in-process  research  and  development  activities  are  considered  indefinite  lived 
until  the  completion  or  abandonment  of  the  associated  research  and  development  efforts.  Upon  reaching  the  end  of  the  relevant 
research  and  development  project,  the  Company  will  amortize  the  acquired  IPR&D  over  its  estimated  useful  life  or  expense  the 
acquired in-process research and development should the research and development project be unsuccessful with no future alternative 
use. 

 Goodwill and IPR&D are not amortized; however, they are assessed for impairment using fair value measurement techniques 
on an annual basis or more frequently if facts and circumstance warrant such a review. The goodwill or IPR&D are considered to be 
impaired if we determine that the carrying value of the reporting unit or IPR&D exceeds its respective fair value.    

The Company performs its goodwill impairment analysis at the reporting unit level, which aligns with the Company’s reporting 
structure and availability of discrete financial information. The Company performs its annual impairment analysis by either comparing 
a reporting unit’s estimated fair value to its carrying amount or doing a qualitative assessment of a reporting unit’s fair value from the 
last  quantitative  assessment  to  determine  if  there  is  potential  impairment.  The  Company  may  do  a  qualitative  assessment  when  the 
results of the previous quantitative test indicated the reporting unit’s estimated fair value was significantly in excess of the carrying 
value  of  its  net  assets  and  it  does  not  believe  there  have  been  significant  changes  in  the  reporting  unit’s  operations  that  would 
significantly  decrease  its  estimated  fair  value  or  significantly  increase  its  net  assets. If  a  qualitative  assessment  is  performed  the 
evaluation  includes  management  estimates  of  cash  flow  projections  based  on  internal  future  projections  and/or  use  of  a  market 
approach by looking at market values of comparable companies. Key assumptions for these projections include revenue growth, future 
gross  and  operating  margin  growth,  and  its  weighted  cost  of  capital  and  terminal  growth  rates.  The  revenue  and  margin  growth  is 
based  on  increased  sales  of  new  and  existing  products  as  we  maintain  our  investment  in  research  and  development.  Additional 
assumed  value  creators  may  include  increased  efficiencies  from  capital  spending.  The  resulting  cash  flows  are  discounted  using  a 
weighted  average  cost  of  capital.  Operating  mechanisms  and  requirements  to  ensure  that  growth  and  efficiency  assumptions  will 
ultimately  be  realized  are  also  considered  in  the  evaluation,  including  timing  and  probability  of  regulatory  approvals  for  Company 
products to be commercialized. The Company’s market capitalization is also considered as a part of its analysis. 

The Company’s annual evaluation for impairment of goodwill consists of two reporting units; the Progentix reporting unit and 
the remainder of the Company (the “primary reporting unit”). In accordance with our policy, we completed our most recent annual 
evaluation  for  impairment  using  the  discounted  cash  flow  valuation  methodology  based  on  discounted  cash  flows  as  of  October 1, 
2015  and  determined  that  no  impairment  existed,  and  it  was  determined  that  no  reporting  unit  of  the  Company  was  at  risk  of 
impairment when assessing the unit’s fair value compared to its carrying value. In addition, no indicators of impairments were noted 
through December 31, 2015 and consequently, no impairment charge has been recorded during the year. 

Intangible  assets  with  a  finite  life,  such  as  acquired  technology,  customer  relationships,  manufacturing  know-how,  licensed 
technology,  supply  agreements  and  certain  trade  names  and  trademarks,  are  amortized  on  a  straight-line  basis  over  their  estimated 
useful life, ranging from 1 to 17 years. Intangible assets with a finite life are tested for impairment whenever events or circumstances 
indicate that the carrying amount may not be recoverable.  

In  determining  the  useful  lives  of  intangible  assets,  the  Company  considers  the  expected  use  of  the  assets  and  the  effects  of 
obsolescence, demand, competition, anticipated technological advances, changes in surgical techniques, market influences and other 
economic  factors.  For  technology  based  intangible  assets,  the  Company  considers  the  expected  life  cycles  of  products  which 
incorporate the corresponding technology. Trademarks and trade names that are related to products are assigned lives consistent with 
the period in which the products bearing each brand are expected to be sold.  

See  Note  2  to  the  Consolidated  Financial  Statements  included  in  this  Annual  Report  for  further  discussion  on  goodwill  and 

intangible assets. 

75 

 
 
Property and Equipment 

Property  and  equipment  are  carried  at  cost  less  accumulated  depreciation.  Depreciation  is  computed  using  the  straight-line 
method over the estimated useful lives of the assets, ranging from 2 to 20 years. The Company depreciates leasehold improvements 
over their estimated useful lives or the term of the applicable lease, whichever is shorter. Leased property meeting certain capital lease 
criteria is capitalized, and the net present value of the related lease payments is recorded as a liability. Amortization of assets under 
capital leases is recorded using the straight-line method over the shorter of the estimated useful lives or the lease terms. Maintenance 
and repairs are expensed as incurred. 

The Company reviews property, plant and equipment for impairment whenever events or changes in circumstances indicate that 
the carrying value of an asset may not be recoverable. An impairment loss would be recognized when estimated future undiscounted 
cash flows relating to the asset are less than its carrying amount. An impairment loss is measured as the amount by which the carrying 
amount of an asset exceeds its fair value.  

Income Taxes 

The asset and liability approach is used to recognize deferred tax assets and liabilities for the expected future tax consequences 
of  temporary  differences  between  the  carrying  amounts  and  the  tax  bases  of  assets  and  liabilities.  Tax  law  and  rate  changes  are 
reflected  in  income  in  the  period  such  changes  are  enacted.  The  Company  includes  interest  and  penalties  related  to  income  taxes, 
including unrecognized tax benefits, within income tax expense. 

The Company’s income tax returns are based on calculations and assumptions that are subject to examination by the Internal 
Revenue  Service  and  other  tax  authorities.  In  addition,  the  calculation  of  the  Company’s  tax  liabilities  involves  dealing  with 
uncertainties in the application of complex tax regulations. The Company recognizes liabilities for uncertain tax positions based on a 
two-step  process.  The  first  step  is  to  evaluate  the  tax  position  for  recognition  by  determining  if  the  weight  of  available  evidence 
indicates that it is more likely than not that the position will be sustained on audit, including resolution of related appeals or litigation 
processes, if any. The second step is to measure the tax benefit as the largest amount that is more than 50% likely of being realized 
upon  settlement.  While  the  Company  believes  it  has  appropriate  support  for  the  positions  taken  on  its  tax  returns,  the  Company 
regularly assesses the potential outcomes of examinations by tax authorities in determining the adequacy of its provision for income 
taxes.  The  Company  continually  assesses  the  likelihood and  amount  of  potential  adjustments  and  adjusts  the  income  tax  provision, 
income taxes payable and deferred taxes in the period in which the facts that give rise to a revision become known. 

The  Company  recognizes  windfall  tax  benefits  associated  with  share-based  awards  directly  to  stockholders’  equity  when 
realized.  A  windfall  tax  benefit  occurs  when  the  actual  tax  benefit  realized  by  the  Company  upon  an  employee’s  disposition  of  a 
share-based award exceeds the deferred tax asset, if any, associated with the award that the Company had recorded. When assessing 
whether  excess  tax  benefits  relating  to  share-based  compensation  have  been  realized,  the  Company  follows  the  with-and-without 
approach excluding any indirect effects of the excess tax deductions. Under this approach, excess tax benefits related to share-based 
compensation are not deemed to be realized until after the utilization of all other tax benefits available to the Company. 

Significant judgment is required in determining our provision for income taxes, our deferred tax assets and liabilities and the 
valuation allowance recorded against our net deferred tax assets. Deferred tax assets and liabilities are determined using the enacted 
tax rates in effect for the years in which those tax assets are expected to be realized. A valuation allowance is established when it is 
more likely than not the future realization of all or some of the deferred tax assets will not be achieved. The evaluation of the need for 
a valuation allowance is performed on a jurisdiction-by-jurisdiction basis, and includes a review of all available positive and negative 
evidence. Factors reviewed include projections of pre-tax book income for the foreseeable future, determination of cumulative pre-tax 
book income after permanent differences, earnings history, and reliability of forecasting. 

See Note 9 to the Consolidated Financial Statements included in this Annual Report for further discussion on income taxes. 

Loss Contingencies 

An estimated loss contingency is accrued in the Company’s financial statements if it is probable or reasonably possible that a 
liability  has  been  incurred  and  the  amount  of  the  loss  can  be  reasonably  estimated.  Based  on  the  Company’s  assessment,  it  has 
adequately accrued an amount for contingent liabilities currently in existence. The Company does not accrue amounts for liabilities 
that it does not believe are probable or that it considers immaterial to its overall financial position. In most cases, significant judgment 
is required to estimate the amount and timing of a loss to be recorded. 

The Company is involved in a number of legal actions arising out of the normal course of our business. The outcomes of these 
legal actions are not within the Company’s complete control and may not be known for prolonged periods of time. In some actions, 
the claimants seek damages as well as other relief, including injunctions barring the sale of products that are the subject of the lawsuit, 
that could require significant expenditures or result in lost revenues. Litigation is inherently unpredictable, and unfavorable resolutions 
could  occur.  As  a  result,  assessing  contingencies  is  highly  subjective  and  requires  judgment  about  future  events.  The  amount  of 
ultimate  loss  may  exceed  the  Company’s  current  accruals,  and  it  is  possible  that  its  cash  flows  or  results  of  operations  could  be 
materially affected in any particular period by the unfavorable resolution of one or more of these contingencies. 

76 

 
 
See  Note  11  to  the  Consolidated  Financial  Statements  included  in  this  Annual  Report  for  further  discussion  on  legal 

proceedings. 

Comprehensive Income (Loss) 

Comprehensive  income  (loss)  is  defined  as  the  change  in  equity  during  a  period  from  transactions  and  other  events  and 
circumstances  from  non-owner  sources.  Comprehensive  income  (loss)  includes  net  of  tax,  unrealized  gains  or  losses  on  the 
Company’s  marketable  securities  and  foreign  currency  translation  adjustments.  The  cumulative  translation  adjustments  included  in 
accumulated  other  comprehensive  loss  were  $11.6  million,  $9.5  million,  and  $3.3  million  at  December 31,  2015,  2014,  and  2013, 
respectively. 

Research and Development 

Research  and  development  costs  are  expensed  as  incurred.  To  the  extent  the  Company  purchases  research  and  development 

assets with a future alternative use the Company will capitalize and amortize the assets over its useful life.  

Product Shipment Costs 

Product  shipment  costs  are  included  in  sales,  marketing  and  administrative  expense  in  the  accompanying  consolidated 
statements of operations and were $21.6 million, $23.6 million, and $21.7 million for the years ended December 31, 2015, 2014, and 
2013, respectively.  The majority of the Company’s shipping costs are related to the loan of instrument sets, which are not sold as part 
of the Company’s core sales offering.  Amounts billed to customers for shipping and handling of products are reflected in revenues 
and are not significant for any period presented. 

Restructuring Charges 

During the year ended December 31, 2014, the Company exited a portion of its New Jersey property and subsequently, in 2015, 
made the decision to terminate the respective lease entirely to reduce its footprint on the east coast of the United States as part of a 
company-wide efficiency effort to match its business needs without adversely impacting its ability to deliver surgeon education and 
local  customer  fulfillment.  As  a  result,  the  Company  recognized  restructuring  charges  of  $2.1  million  and  $6.4  million  during  the 
years ended December 31, 2015 and 2014, respectively. The restructuring charges mainly consist of future rental payments through 
2017,  and  lease  termination  fee,  net  of  estimated  future  sublease  income  and  deferred  rent  write-offs.  The  Company  also  recorded 
impairment charges associated with the exit related to leasehold improvement write-offs of $0.9 million and $2.2 million, in 2015 and 
2014,  respectively.  All  of  the  associated  charges  are  recorded  in  sales,  marketing  and  administrative  expense  in  the  Consolidated 
Statements of Operations. 

Business Transition Costs 

 The  Company  incurs  various  costs  related  to  business  combination  and  integration  activities.  These  activities  include 
restructuring and integrating acquired entities and existing operations through business consolidation activities. Types of costs include 
severance, relocation, consulting, and other costs directly related to the activity. The Company recorded such expenses of $6.5 million 
and  $1.4 million  during  the  years  ended  December  31,  2015  and  2014,  respectively. The  expense  related  to  these  activities  was 
minimal during the year ended December 31, 2013. 

Stock-based Compensation 

Stock-based  compensation  expense  for  equity-classified  awards,  principally  related  to  restricted  stock  units  (“RSUs”)  and 
performance  restricted  stock  units  (“PRSUs”),  is  measured  at  the  grant  date  based  on  the  estimated  fair  value  of  the  award  and  is 
recognized over the employee’s requisite service period on an accelerated basis. The fair value of equity instruments that are expected 
to vest is recognized and amortized over the requisite service period. The Company has granted awards with up to five year graded or 
cliff  vesting  terms  (in  each  case,  with  service  through  the  date  of  vesting  being  required).  No  exercise  price  or  other  monetary 
payment  is  required for  receipt of  the  shares  issued  in  settlement  of  the respective  award;  instead,  consideration  is furnished  in  the 
form of the participant’s service to the Company. 

The fair value of RSUs including PRSUs with pre-defined performance criteria is based on the stock price on the date of grant 
whereas  the  expense  for  PRSU  with  pre-defined  performance  criteria  is  adjusted  with  the  probability  of  achievement  of  such 
performance criteria at each period end. The fair value of the PRSUs that are earned based on the achievement of pre-defined market 
conditions for total shareholder return (“TSR PRSUs”) is estimated on the date of grant using a Monte Carlo valuation model. The key 
assumptions in applying this model are an expected volatility and a risk-free interest rate.  

Stock-based  compensation  expense  is  adjusted  from  the  grant  date  to  exclude  expense  for  awards  that  are  expected  to  be 
forfeited. The forfeiture estimate is adjusted as necessary through the vesting date so that full compensation cost is recognized only for 
awards that vest. The Company assesses the reasonableness of the estimated forfeiture rate at least annually, with any change to be 
made on a cumulative basis in the period the estimated forfeiture rates change. The Company considered its historical experience of 
pre-vesting forfeitures on awards by each homogenous group of shareowners as the basis to arrive at its estimated annual pre-vesting 
forfeiture rates. 

77 

 
 
The Company estimates the fair value of stock options issued under its equity incentive plans and shares issued to shareowners 
under its employee stock purchase plan using a Black-Scholes option-pricing model on the date of grant. The Black-Scholes option-
pricing model incorporates various and highly sensitive assumptions including expected volatility, expected term and risk-free interest 
rates.  The  expected  volatility  is  based  on  the  historical  volatility  of  the  Company’s  common  stock  over  the  most  recent  period 
commensurate  with  the  estimated  expected  term  of  the  Company’s  stock  options  and  ESPP  which  is  derived  from  historical 
experience. The risk-free interest rate for periods within the contractual life of the option is based on the U.S. Treasury yield in effect 
at the time of grant. The Company has never declared or paid dividends and has no plans to do so in the foreseeable future.  

See Note 8 to the Consolidated Financial Statements included in this Annual Report for further discussion on stockholder equity 

and stock-based compensation. 

Net Income (Loss) Per Share 

The Company computes basic net income (loss) per share using the weighted-average number of common shares outstanding 
during the period. Diluted net income (loss) assumes the conversion, exercise or issuance of all potential common stock equivalents, 
unless  the  effect  of  inclusion  would  be  anti-dilutive.  For  purposes  of  this  calculation,  common  stock  equivalents  include  the 
Company’s  stock  options, unvested  RSUs,  including  those  with performance  and  market  conditions, warrants,  and  the  shares  to  be 
issued upon the conversion of the Senior Convertible Notes. For the years 2014 and 2013, no shares related to the assumed conversion 
of the Senior Convertible Notes were included in the diluted net income (loss) calculation because the inclusion of such shares would 
have had an anti-dilutive effect. The shares to be issued upon exercise of all outstanding warrants were excluded from the diluted net 
income (loss) calculation for the years 2014 and 2013 because the inclusion of such shares would have had an anti-dilutive effect. The 
contingently issuable shares are included in basic net income (loss) per share as of the date that all necessary conditions have been 
satisfied and are included in the denominator for dilutive calculation for the entire period if such shares would be issuable as of the 
end of the reporting period assuming the end of the reporting period was the end of the contingency period. 

The following table sets forth the computation of basic and diluted earnings (loss) per share (in thousands, except share data):   

Numerator: 

Net income (loss) available to the Company 
Denominator for basic and diluted net income (loss) per 
   share: 

Weighted average common shares outstanding for 
   basic 
Dilutive potential common stock outstanding: 

Stock options and ESPP 
RSUs 
Warrants 
Senior Convertible Notes 

Weighted average common shares outstanding for 
   diluted 

Basic net income (loss) per share attributable to 
   NuVasive, Inc. 
Diluted net income (loss) per share attributable to 
   NuVasive, Inc. 

Year Ended December 31, 
2014 

2013 

2015 

  $

66,291  $

(16,720 )   $ 

7,902 

48,687 

46,715       

44,461 

1,089 
1,157 
177 
1,314 

—       
—       
—       
—       

416 
1,909 
— 
— 

52,424 

46,715       

46,786 

$

$

1.36  $

(0.36 )   $ 

0.18 

1.26  $

(0.36 )   $ 

0.17  

The  following  weighted  outstanding  common  stock  equivalents  were  not  included  in  the  calculation  of  net  income  (loss)  per 

diluted share because their effects were anti-dilutive (in thousands):  

Stock Options, ESPP, and RSUs 
Warrants 
Senior Convertible Notes 
Total 

Year Ended December 31, 
2014 

2013 

2015 

40     
4,777     
—     
4,817     

8,902        
9,553        
9,553        
28,008        

5,015 
12,709 
9,890 
27,614  

78 

 
 
  
 
 
  
 
    
     
 
   
 
 
       
 
 
 
 
 
       
 
 
 
 
   
 
 
       
 
   
 
   
 
   
 
   
 
 
 
 
 
 
  
  
 
 
  
 
 
 
     
 
   
   
   
   
 
2.    Balance Sheet Details  

Property and Equipment, net 

Property and equipment, net, consisted of the following (in thousands, except years):  

Instrument sets 
Machinery and equipment 
Computer equipment and software 
Leasehold improvements 
Furniture and fixtures 
Building and improvements 
Land 

Less: accumulated depreciation and 
amortization 

  $

Useful Life 
4 
5 to 7 
3 to 7 
2 to 15 
3 to 7 
10 to 20 
—

December 31, 

2015 

2014 

214,893    $ 
26,871     
55,480     
17,331     
5,884     
10,875     
1,288     
332,622     

189,774  
25,413  
52,269  
20,083  
7,282  
7,507  
541  
302,869  

(191,181)   
141,441    $ 

(174,304 )
128,565   

  $

Our property and equipment mainly consisted of instrument sets, which we loan to surgeons and hospitals that purchase implants, 

biologics and disposables for use in individual procedures, and computer equipment and software. 

Depreciation  expense  was  $49.8  million,  $52.3  million,  and  $43.8  million  for  the  years  ended  December 31,  2015,  2014  and 
2013,  respectively.  At  December 31,  2015  and  2014,  gross  assets  recorded  under  capital  leases  of  $1.5  million  are  included  in 
machinery  and  equipment.  Depreciation  of  the  assets  under  capital  leases  is  included  in  depreciation  expense.  The  Company 
depreciates leasehold improvements over their estimated useful lives or the term of the applicable lease, whichever is shorter. 

Included  in  the  depreciation  expense  recognized  during  the  year  ended  December 31,  2014  was  $4.2  million  of  accelerated 
depreciation  as  a  result  of  the  Company’s  plan  to  consolidate  its  offices  located  in  San  Diego,  California  into  one  corporate 
headquarters. This project commenced during the year ended December 31, 2014 and completed in 2015. As a result, certain long-
lived assets, primarily leasehold improvements, were abandoned and replaced during the respective construction period. In accordance 
with the authoritative guidance, the Company shortened the depreciable lives of the impacted assets, which resulted in $4.2 million of 
accelerated depreciation, which was  included in  sales,  marketing  and  administrative  expenses, during  the  year  ended December 31, 
2014,  that  would  have  otherwise  been  recorded  in  future  periods.  There  is  no  impact  to  the  Company’s  Consolidated  Statement  of 
Operations over the life of the respective assets. The net effect of this change in estimate on net income and earnings per share for the 
year ended December 31, 2014 was $1.8 million and $0.04, respectively. No accelerated depreciation was recorded in 2015. 

Capitalized internal-use software costs include only those direct costs associated with the actual development or acquisition of 
computer  software  for  internal  use,  including  costs  associated  with  the  design,  coding,  installation,  and  testing  of  the  system.  At 
December 31,  2015  and  2014,  the  Company  had  $17.6  million  and  $17.3  million  in  unamortized  capitalized  internal-use  software 
costs,  respectively.  Amortization  expense  related  to  capitalized  internal-use  software  costs  was  $7.3  million,  $7.7  million  and  $5.5 
million for the years ended December 31, 2015, 2014 and 2013, respectively.  

Goodwill and Intangible Assets 

Goodwill and intangible assets as of December 31, 2015 consisted of the following (in thousands, except years):  

Intangible Assets Subject to Amortization: 
Developed technology 
Manufacturing know-how and trade secrets 
Trade name and trademarks 
Customer relationships 
Total intangible assets subject to amortization 

Intangible Assets Not Subject to Amortization: 
Goodwill 
Total goodwill and intangible assets, net 

   Weighted- 
Average 

   Amortization 

Period 
(in years) 

Gross 
Amount 

   Accumulated      
Intangible 
   Amortization      Assets, net 

9 
12 
11 
8 
10 

  $

  $

92,648     $ 
21,787       
9,500       
44,752       
168,687     $ 

(37,382 )    $
(13,296 )     
(5,068 )     
(27,865 )     
(83,611 )    $

55,266 
8,491 
4,432 
16,887 
85,076 

154,281 
239,357  

     $

79 

 
 
  
  
  
 
 
  
 
    
 
   
   
   
   
   
   
  
  
   
  
   
  
  
   
   
  
 
    
  
      
  
 
  
  
   
  
 
    
  
      
  
 
  
 
    
  
    
  
  
 
 
 
  
  
 
 
 
    
      
         
         
 
 
 
   
 
   
 
   
 
 
      
         
         
 
    
      
         
      
    
      
         
Goodwill and intangible assets as of December 31, 2014 consisted of the following (in thousands, except years):  

Intangible Assets Subject to Amortization: 
Developed technology 
Manufacturing know-how and trade secrets 
Trade name and trademarks 
Customer relationships 
Total intangible assets subject to amortization 
Intangible Assets Not Subject to Amortization: 
In-process research and development 
Goodwill 
Total goodwill and intangible assets, net 

   Weighted- 
Average 

   Amortization 

Period 
(in years) 

Gross 
Amount 

   Accumulated      
Intangible 
   Amortization      Assets, net 

9 
12 
11 
8 
10 

  $

  $

79,008    $ 
21,879      
9,500      
43,153      
153,540    $ 

(27,760 )   $
(11,640 )    
(4,264 )    
(23,961 )    
(67,625 )   $

51,248 
10,239 
5,236 
19,192 
85,915 

10,640 
154,443 
250,998  

    $

Total expense related to the amortization of intangible assets was $16.1 million, $13.6 million and $19.3 million for the years 

ended December 31, 2015, 2014 and 2013, respectively.  

In October 2015, the Company concluded the relevant research and development project associated with the $10.6 million in-
process research and development intangible asset acquired in a previous business combination. At the conclusion of the project, the 
Company  began  amortizing  the  developed  technology  associated  with  the  project over  the  estimated useful  life  of approximately  6 
years. 

During  the  year  ended  December  31,  2014,  the  Company  recorded  an  impairment  charge  of  $10.7  million  related  to  the 
developed technology acquired from Cervitech in 2009. The primary factors contributing to this impairment charge was the reduction 
in the Company revenue estimate and related decrease to estimated cash flows for the technology.  

See  Note  1  to  the  Consolidated  Financial  Statements  included  in  this  Annual  Report  for  further  discussion  on  impairment 

charges. 

Total future amortization expense related to intangible assets subject to amortization at December 31, 2015 is set forth in the 

table below (in thousands):  

2016 
2017 
2018 
2019 
2020 
Thereafter through 2026 
Total future amortization expense 

  $ 

  $ 

17,589  
14,392  
13,882  
12,528  
12,117  
14,568  
85,076  

The changes to goodwill are comprised of the following (in thousands):  

Balance at January 1 
Addition recorded in connection with acquisition 
Reduction recorded in connection with disposal of business 
Other 
Balance at December 31 

December 31, 

2015 

2014 

154,443     $ 
—       
—       
(162 )     
154,281     $ 

154,944 
— 
(292)
(209)
154,443  

$

$

80 

 
 
 
  
  
  
   
  
 
    
  
      
  
 
  
  
   
  
 
    
  
      
  
 
  
 
    
  
    
  
  
 
 
 
  
  
 
 
 
    
      
        
        
 
 
 
   
 
   
 
   
 
    
      
        
        
 
    
      
        
     
    
      
        
     
    
      
        
 
  
  
  
    
  
 
  
  
  
  
    
  
  
    
  
  
    
  
  
    
  
  
    
  
  
 
  
  
 
  
  
    
 
  
  
 
  
 
  
 
  
Accounts Payable and Accrued Liabilities 

Accounts payable and accrued liabilities consisted of the following (in thousands):  

 Accrued expenses 
 Distributor commissions payable 
 Accounts payable 
 Other taxes payable 
 Royalties payable 
Others 
 Accounts payable and accrued liabilities 

December 31, 

2015 

2014 

31,187   $ 
8,502     
6,792     
6,386     
4,454     
3,665     
60,986   $ 

49,014  
8,329  
13,648  
6,888  
51,377  
4,068  
133,324  

$

$

Royalties payable decreased in 2015 as a result of the gain of $56.4 million related to a litigation accrual change resulting from 
the legal proceedings in Phase 1 of the Medtronic litigation whereby the damages award by the jury was overturned. See Note 11 to 
the  Consolidated  Financial  Statements  included  in  this  Annual  Report  for  further  discussion  on  the  Medtronic  litigation  matters. 
Accrued  expenses  as  of  December  31,  2014  included  $27.4  million  of  intangible  assets  which  were  paid  during  the  year  ended 
December 31, 2015. 

81 

 
 
  
  
  
 
  
  
    
 
  
  
 
  
 
  
 
  
 
  
 
  
3.    Marketable Securities  

The Company invests its excess cash in marketable securities and the composition of marketable securities is as follows (in thousands, 
except years): 

Contractual 
Maturity 
(in Years)

Amortized 
Cost 

Gross 
Unrealized 
Gains 

Gross 
Unrealized 
Losses

    Fair Value 

December 31, 2015: 
Classified as current assets 
Certificates of deposit 
Corporate notes 
Commercial paper 
Securities of government-sponsored entities 
Short-term marketable securities 

Classified as non-current assets 

Certificates of deposit 
Corporate notes 
Securities of government-sponsored entities 
Long-term marketable securities 

  $

  Less than 1 
  Less than 1 
  Less than 1 
  Less than 1 

  1 to 2 
  1 to 2 
  1 to 2 

6,615    $
108,739     
21,991     
28,284     
165,629     

12,392     
43,857     
56,412     
112,661     

—      $ 
5        
—        
—        
5        

—        
—        
—        
—        

—    $
(173)    
—     
(38)    
(211)    

—     
(109)    
(220)    
(329)    

6,615 
108,571 
21,991 
28,246 
165,423 

12,392 
43,748 
56,192 
112,332 

Total marketable securities at December 
31, 2015 

  $

278,290    $

5      $ 

(540)   $

277,755 

December 31, 2014: 
Classified as current assets 
Certificates of deposit 
Corporate notes 
Commercial paper 
U.S. government treasury securities 
Securities of government-sponsored entities 
Short-term marketable securities 

Classified as non-current assets 

Corporate notes 
Securities of government-sponsored entities 
Long-term marketable securities 

Classified as restricted investments 

U.S. government treasury securities 
Securities of government-sponsored entities 

Restricted investments 

  $

  Less than 1 
  Less than 1 
  Less than 1 
  Less than 1 
  Less than 1 

  1 to 2 
  1 to 2 

  Less than 2 
  Less than 2 

282    $
129,037     
11,290     
1,500     
78,333     
220,442     

14,082     
28,996     
43,078     

51,331     
42,862     
94,193     

—      $ 
8        
—        
1        
12        
21        

—        
—        
-        

13        
2        
15        

—    $
(105)    
—     
—     
(29)    
(134)    

282 
128,940 
11,290 
1,501 
78,316 
220,329 

(13)    
(23)    
(36)    

(13)    
(54)    
(67)    

14,069 
28,973 
43,042 

51,331 
42,810 
94,141 

Total marketable securities at December 
31, 2014 

  $

357,713    $

36      $ 

(237)   $

357,512   

As  of  December 31,  2015,  the  Company  had  no  investments  that  were  in  a  significant  unrealized  loss  position  and  no 

impairment charges were recorded during the periods presented.  

Foreign Currency and Derivative Financial Instruments  

Some  of  the  Company’s  reporting  entities  conduct  a  portion  of  their  business  in  currencies  other  than  the  entity’s  functional 
currency. These transactions give rise to receivables and payables that are denominated in currencies other than the entity’s functional 
currency. The value of these receivables and payables is subject to changes in currency exchange rates from the point at which the 
transactions are originated until the settlement in cash. Both realized and unrealized gains and losses in the value of these receivables 
and payables are included in the determination of net income. Net currency exchange gains (losses), which includes gains and losses 
from  derivative  instruments,  were  $0.3  million,  $(2.6)  million  and  $0.7  million  for  the  years  ended  December 31,  2015,  2014  and 
2013, respectively, and are included in other income (expense) in the Consolidated Statements of Operations. 

As  of  December  31,  2015  and  2014,  a  notional  principal  amount  of $8.5 million  and  $26.0  million,  respectively,  was 
outstanding  in  foreign  currency  forward  contracts  to  hedge  currency  risk  relative  to  foreign  receivables  and  payables.  In  2013,  the 
Company did not have any gain or loss recognized on derivative instruments. 

82 

 
 
 
  
 
  
    
     
 
    
      
        
         
        
 
    
      
        
         
        
 
   
   
   
    
   
    
      
        
         
        
 
   
   
   
    
   
    
  
    
   
  
     
  
       
  
     
  
 
    
      
        
         
        
 
    
      
        
         
        
 
   
   
   
   
    
   
    
      
        
         
        
 
   
   
    
   
    
      
        
         
        
 
   
   
    
   
    
The Company’s currency exposures vary, but are primarily concentrated in the pound sterling, the euro, the Australian dollar, 
the Singapore dollar, and the yen. The Company will continuously monitor the costs and the impact of foreign currency risks upon the 
financial results as part of the Company’s risk management program. The Company does not use derivative financial instruments for 
speculation or trading  purposes  or for  activities  other  than  risk  management.  The  Company does not  require  and  is not  required  to 
pledge collateral for these financial instruments and does not carry any master netting arrangements to mitigate the credit risk.  

The following table summarizes the fair values of derivative instruments at December 31, 2015 and 2014:   

(in thousands) 
Derivatives instruments not designated as 
cash flow hedges 

Forward exchange contracts 

Total derivatives 

Asset Derivatives 

Liability Derivatives 

  Balance Sheet
Location 

December 31,  December 31, Balance Sheet   December 31,

2015 

2014 

Location 

2015 

December 31, 
2014 

Fair Value

Fair Value 

Other current
assets 

* $
$                        * $

Other current 
liabilities 

—
—   

$ 
 $ 

—
*
— $                        *

 *De minimus amount recognized in the hedge relationship. 

The following table summarizes the effect of derivative instruments on the Consolidated Statements of Operations for the years 

ended December 31, 2015 and 2014:   

(in thousands) 
Derivatives instruments not designated as cash flow hedges 

Forward exchange contracts 

Total derivatives 

   Year ended December 31, 2015 
Amount of 
(Gain)/Loss 

Location of 
(Gain)/Loss 
   Recognized in 

Income 

Income 

Location of 
(Gain)/Loss 

      Year ended December 31, 2014 
Amount of 
(Gain)/Loss 
Recognized in   
Income 

Income 

  Recognized in        Recognized  in 

Other (income)
expense 

$
  $

Other (income)
expense 

(1,693 ) 
(1,693 )      

$
  $

(730)
(730)

83 

 
 
  
 
  
 
  
  
 
  
 
 
   
  
    
  
     
  
 
 
   
 
  
  
 
  
  
     
 
  
  
     
 
  
  
     
 
    
      
       
      
 
 
 
  
 
    
  
4.    Fair Value Measurements   

The fair values of the Company’s assets and liabilities, including cash equivalents, marketable securities, restricted investments, 
derivatives,  and  contingent  considerations  are  measured  at  fair  value  on  a  recurring  basis,  and  are  determined  under  the  fair  value 
categories as follows (in thousands):  

December 31, 2015: 
Cash Equivalents and Marketable Securities: 

Money market funds 
Certificates of deposit 
Corporate notes 
Commercial paper 
Securities of government-sponsored entities 
Total cash equivalents and marketable securities 

December 31, 2014: 

Cash Equivalents, Marketable Securities and Restricted 
Investments: 
Money market funds 
Certificates of deposit 
Corporate notes 
Commercial paper 
U.S. government treasury securities 
Securities of government-sponsored entities 

Total cash equivalents, marketable securities and restricted 
investments 
Contingent Consideration: 

Acquisition-related liabilities, current 

Total contingent consideration 

Quoted Price in       Significant Other  
  Active Market      Observable Inputs 

Total 

(Level 1) 

(Level 2) 

Significant 
Unobservable   
Inputs (Level 3)  

  $

  $

  $

68,425    $
19,007     
152,319     
21,991     
115,929     
377,671    $

68,425     $ 
19,007       
—       
—       

87,432     $ 

—    $
—     
152,319     
21,991     
115,929     
290,239    $

39,963    $
282     
143,009     
11,290     
52,831     
150,101     

39,963     $ 
282       
—       
—       
52,831       
—       

—    $
—     
143,009     
11,290     
—     
150,101     

$

397,476    $

93,076     $ 

304,400    $

— 
— 
— 
— 
— 
— 

— 
— 
— 
— 
— 
— 

— 

  $
  $

(644)   $
(644)   $

—     $ 
—     $ 

—    $
—    $

(644)
(644)

The carrying amounts of certain financial instruments such as cash and cash equivalents, accounts receivable, prepaid expenses, 
other current assets, accounts payable, accrued expenses, and other current liabilities as of December 31, 2015 and December 31, 2014 
approximate their related fair values due to the short-term maturities of these instruments. 

The  fair  value  of  certain  financial  instruments  was  measured  and  classified  within  Level 1  based  on  quoted  prices.  Certain 
financial instruments classified within Level 2 of the fair value hierarchy include the types of instruments that trade in markets that are 
not considered to be active, but are valued based on quoted market prices, broker or dealer quotations, or alternative pricing sources 
with reasonable levels of price transparency.  

To  manage  foreign  currency  exposure  risks,  the  Company  uses  derivatives  for  activities  in  entities  that  have  short-term 
intercompany receivables and payables denominated in a currency other than the entity’s functional currency. The fair value is based 
on a quoted market price (Level 1). See Note 3 to the Consolidated Financial Statements included in this Annual Report for further 
discussion on the hedge transactions. 

The fair value, based on a quoted market price (Level 1), of the Company’s outstanding Senior Convertible Notes due 2017 at 
December 31, 2015 and December 31, 2014 was approximately $551.4 million and $516.1 million, respectively. The carrying value of 
the  Company’s  Senior  Convertible  Notes  is  discussed  in  Note 6  to  the  Consolidated  Financial  Statements  included  in  this  Annual 
Report.  

Certain  contingent  consideration  liabilities  are  classified  within  Level  3  of  the  fair  value  hierarchy  because  they  use 
unobservable  inputs.  For  those  liabilities,  fair  value  is  determined  using  a  probability-weighted  discounted  cash  flow  model,  the 
significant inputs which are not observable in the market. 

84 

 
 
 
  
 
  
    
  
  
  
 
     
 
      
        
         
        
 
      
        
         
        
 
   
   
   
   
       
  
   
     
       
     
 
   
     
       
     
 
 
 
     
       
     
 
   
   
   
   
   
 
   
     
       
     
 
 
The following table sets forth the changes in the estimated fair value of the Company’s liabilities measured on a recurring basis 

using significant unobservable inputs (Level 3) (in thousands):  

Fair value measurement at January 1 
Contingent consideration assumed 
Change in fair value measurement included in operating 
expenses 
Contingent consideration paid or settled 
Fair value measurement at December 31 

  $

  $

2015 

2014 

644    $ 
431      

1,212  
—  

(36)     
(1,039)     
—    $ 

40  
(608 )
644   

Non-financial assets and liabilities measured on a nonrecurring basis  

Certain non-financial assets and liabilities are measured at fair value, usually with Level 3 inputs including discounted cash flow 
method or cost method, on a nonrecurring basis in accordance with authoritative guidance. These include items such as nonfinancial 
assets  and  liabilities  initially  measured  at  fair  value  in  a  business  combination  and  non-financial  long-lived  assets  measured  at  fair 
value  for  an  impairment  assessment. In  general,  non-financial  assets,  including  goodwill,  intangible  assets  and  property  and 
equipment,  are  measured  at  fair  value  when  there  is  an  indication  of  impairment  and  are  recorded  at  fair  value  only  when  any 
impairment is recognized. The carrying values of the Company’s capital lease obligations approximated their estimated fair value as 
of  December 31,  2015  and  2014.  The  Company  has  obligations  under  certain  consultancy  arrangements  based  on  achievement  of 
specified milestones. There was no accrual as of December 31, 2015 or 2014, related to these payments. 

In  both  2015  and  2014,  the  Company  recognized  impairment  charges  related  to  leasehold  improvement  write-offs  associated 
with  the  lease  termination  in  New  Jersey.  See  Note  1  to  the  Consolidated  Financial  Statements  included  in  this  Annual  Report  for 
further discussion on the New Jersey lease termination and associated charges. 

During  the  year  ended  December  31,  2014,  the  Company  recorded  an  impairment  charge  of  $10.7  million  related  to  the 

developed technology acquired from Cervitech in 2009. 

See  Note  1  to  the  Consolidated  Financial  Statements  included  in  this  Annual  Report  for  further  discussion  on  impairment 

analysis and leasehold related charges. 

5.    Business Combinations  

The  Company  has  completed  acquisitions  that  were  not  considered  individually  or  collectively  material  to  the  overall 
Consolidated  Financial  Statements  and/or  the  results  of  the  Company's  operations.  These  acquisitions  have  been  included  in  the 
Consolidated  Financial  Statements  from  the  respective  dates  of  the  acquisitions.  The  Company  recognizes  the  assets  acquired, 
liabilities assumed, and any non-controlling interest at fair value at the date of acquisition. 

Contingent Consideration Liabilities   

Contingent  consideration  arrangements  associated  with  certain  asset  and/or  business  acquisitions  include  future  payment 
obligations  based  on  certain  technological  or  operational  milestones.  For  those  contingent  arrangements  entered  in  as  a  result  of 
business  combinations,  the  Company  records  these  obligations  at  fair  value  at  the  time  of  acquisition  with  subsequent  fair  value 
adjustments to the contingent consideration reflected in the line items of the Consolidated Statement of Operations commensurate with 
the  nature  of  the  contingent  consideration.  At December  31,  2015,  the  Company  had  no  contingent  consideration  liabilities 
outstanding (see Note 4 to the Consolidated Financial Statements included in this Annual Report for further discussion). 

Investment in Progentix Orthobiology, B.V.  

In 2009, the Company completed the purchase of forty percent (40%) of the capital stock of Progentix, a company organized 
under  the  laws  of  the  Netherlands,  from  existing  shareholders  (the  Progentix  Shareholders)  pursuant  to  a  Preferred  Stock  Purchase 
Agreement for $10.0 million in cash (the Initial Investment). As of December 31, 2015, NuVasive loaned Progentix cumulatively $5.3 
million at an interest at a rate of 6% per year. NuVasive is not obligated to provide additional funding. 

85 

 
 
  
 
  
 
  
 
     
 
   
 
 
   
 
 
In accordance with authoritative guidance, the Company has determined that Progentix is a variable interest entity, (or “VIE”) as 
it does not have the ability to finance its activities without additional subordinated financial support and its equity investors will not 
absorb  their  proportionate  share  of  expected  losses  and  will  be  limited  in  the  receipt  of  the  potential  residual  returns  of  Progentix. 
Additionally, pursuant to this guidance, NuVasive is considered its primary beneficiary as NuVasive has both the power to direct the 
economically significant activities of Progentix and the obligation to absorb losses of, or the right to receive benefits from, Progentix. 
Accordingly, the financial position and results of operations of Progentix have been included in the Company’s consolidated financial 
statements from the date of the Initial Investment. The liabilities recognized as a result of consolidating Progentix do not represent 
additional claims on the Company’s general assets. The creditors of Progentix have claims only on the assets of Progentix, which are 
not material, and the assets of Progentix are not available to NuVasive.  

The equity interests in Progentix not owned by the Company, which includes shares of both common and preferred stock, are 
reported  as  non-controlling  interests  on  the  consolidated  balance  sheet  of  the  Company.  The  preferred  stock  represents  18%  of  the 
non-controlling equity interests and provides for a cumulative 8% dividend, if and when declared by Progentix’s Board of Directors. 
As the rights of the preferred stock are substantially the same as those of the common stock, the preferred stock is classified as non-
controlling interest and shares in the allocation of the losses incurred by Progentix. Losses incurred by Progentix are charged to the 
Company and to the non-controlling interest holders based on their ownership percentage. The Option Agreement that was entered 
into between NuVasive, Progentix and the Progentix Shareholders were not considered to be freestanding financial instruments during 
the Option Period as defined by authoritative guidance. Therefore, during the Option Period, the Remaining Shares and the Option 
Agreement were accounted for as a combined unit on the consolidated financial statements as a redeemable non-controlling interest 
that was initially recorded at fair value and classified as mezzanine equity. Upon the expiration of the Option Agreement on June 13, 
2013, the non-controlling interest was no longer redeemable and therefore, pursuant to the authoritative guidance, the non-controlling 
interest  was  reclassified  out  of  mezzanine  equity  to  its  own  component  of  total  equity  within  the  Company’s  consolidated  balance 
sheet.  

Total assets and liabilities of Progentix included in the accompanying consolidated balance sheet are as follows (in thousands):  

Total current assets 
Identifiable intangible assets, net 
Goodwill 
Other long-term assets 
Accounts payable & accrued expenses 
Deferred tax liabilities, net 
Non-controlling interests 

  $

December 31, 

2015 

2014 

353    $ 
13,048      
12,654      
—      
574      
1,496      
7,309      

839  
13,935  
12,654  
1  
542  
2,770  
8,310  

The following is a reconciliation of equity attributable to the non-controlling interests (in thousands):  

Non-controlling interests at beginning of period 
Less: Net (loss) attributable to the non-controlling interests 
   subsequent to reclassification from mezzanine to equity 
Non-controlling interests at end of period 

Year Ended December 31, 

2015 

2014 

  $

8,310    $ 

9,086  

(1,001)     
7,309    $ 

(776 )
8,310   

  $

86 

 
 
  
  
 
 
  
 
    
 
   
   
   
   
   
   
  
  
 
 
  
 
     
 
 
 
 Impulse Monitoring Inc. and Physician Practices 

The Company maintains contractual relationships with several physician practices ("PCs") which were inherited through the 

2011 acquisition of Impulse Monitoring Inc. Under the respective contracts' terms, PCs provide the physician oversight services 
associated with IOM services. The Company provides management services to the PCs including all non-medical services, 
management reporting, billing and collections of all charges for medical services provided as well as administrative support. The PCs 
pay the Company a monthly management fee for these services. In accordance with authoritative guidance, the Company has 
determined that the PCs are variable interest entities and the Company has controlling financial interests in the PCs as it has both the 
power to direct the economically significant activities of the PCs, and the obligation to absorb losses of, or the right to receive benefits 
from, the PCs. Therefore, the accompanying Consolidated Financial Statements include the accounts of the PCs from the date of 
acquisition.  During the periods presented, the result of PCs was immaterial to our financials. The creditors of the PCs have claims 
only on the assets of the PCs, which are not material, and the assets of the PCs are not available to the Company. 

6.    Senior Convertible Notes  

The carrying values of the Company’s Senior Convertible Notes are as follows (in thousands):  

2.75% Senior Convertible Notes due 2017: 

Principal amount 
Unamortized debt discount 
Total Senior Convertible Notes 

Senior Convertible Notes due 2017 

December 31, 

2015 

2014 

  $

  $

402,500    $ 
(25,958)    
376,542    $ 

402,500  
(41,754 )
360,746   

In  June  2011,  the  Company  issued  $402.5  million  principal  amount  of  unsecured  Senior  Convertible  Notes  with  a  stated 
interest  rate  of  2.75%  and  a  maturity  date  of  July 1,  2017  (the  "2017  Notes").  The  net  proceeds  from  the  offering,  after  deducting 
initial  purchasers'  discounts  and  costs  directly  related  to  the  offering,  were  approximately  $359.2  million.  The  2017  Notes  may  be 
settled in cash, stock, or a combination thereof, solely at the Company's discretion. It is the Company's current intent and policy to 
settle all conversions through combination settlement, which involves satisfying the principal amount outstanding with cash and any 
note conversion value over the principal amount in shares of the Company's common stock. The initial conversion rate of the 2017 
Notes is 23.7344 shares per $1,000 principal amount, which is equivalent to a conversion price of approximately $42.13 per share, 
subject  to  adjustments.  The  Company  uses  the  treasury  share  method  for  assumed  conversion  of  the  2017  Notes  to  compute  the 
weighted average shares of common stock outstanding for diluted earnings per share. The Company also entered into transactions for 
convertible note hedge (the "2017 Hedge") and warrants (the "2017 Warrants") concurrently with the issuance of the 2017 Notes.  

The cash conversion feature of the 2017 Notes (the “Embedded Conversion Derivative”) required bifurcation from the Notes and 
was initially accounted for as a derivative liability and debt discount of $88.9 million upon issuance of the Notes without authorization 
of issuing additional common stocks for the conversion.  Upon obtaining stockholder approval for the additional authorized shares of 
the  Company’s  common  stock,  the  derivative  liability  was  reclassified  to  stockholders’  equity,  which  resulted  in  recognizing 
cumulatively  $39.5  million  in  other  income  for  change  in  fair  value  measurement  and  $49.4  million  in  additional  paid-in-capital 
during 2011. The effective interest rate on the 2017 Notes is 8.0%, which includes the interest on the notes, amortization of the debt 
discount  and  debt  issuance  costs.  The  interest  expense  recognized  on  the  2017  Notes  during  the  year  ended  December  31,  2015 
includes $11.1 million and $15.8 million for the contractual coupon interest and the accretion of the debt discount, respectively. The 
interest expense recognized on the 2017 Notes during the year ended December 31, 2014 includes $11.1 million and $14.7 million for 
the contractual coupon interest and the accretion of the debt discount, respectively. Interest on the 2017 Notes began accruing upon 
issuance and is payable semi-annually. 

87 

 
 
 
 
  
 
 
  
 
   
 
      
        
 
   
 
 
 
Prior  to  January 1,  2017,  holders  may  convert  their  2017  Notes  only  under  the  following  conditions:  (a)  during  any  calendar 
quarter  beginning  October 1,  2011,  if  the  reported  sale  price  of  the  Company's  common  stock  for  at  least  20  days  out  of  30 
consecutive  trading  days  ending  on  the  last  trading  day  of  the  immediately  preceding  calendar  quarter  is  greater  than  130%  of  the 
conversion price on each applicable trading day; (b) during the five business day period in which the trading price of the 2017 Notes 
falls below 98% of the product of (i) the last reported sale price of the Company's common stock and (ii) the conversion rate on that 
date; and (c) upon the occurrence of specified corporate events, as defined in the 2017 Notes. From January 1, 2017 and until the close 
of business  on  the  second  scheduled  trading day  immediately  preceding  July 1,  2017,  holders  may  convert  their 2017  Notes  at  any 
time  (regardless  of  the  foregoing  circumstances).  The  Company  may  not  redeem  the  2017  Notes  prior  to  maturity.  No  principal 
payments  are  due  on  the  2017  Notes  prior  to  maturity.  Other  than  restrictions  relating  to  certain  fundamental  changes  and 
consolidations, mergers or asset sales and customary anti-dilution adjustments, the 2017 Notes do not contain any financial covenants 
and do not restrict the Company from paying dividends or issuing or repurchasing any of its other securities. The Company is unaware 
of any current events or market conditions that would allow holders to convert the 2017 Notes.  

2017 Hedge 

In connection with the offering of the 2017 Notes, the Company entered into the hedge transaction with the initial purchasers 
and/or  their  affiliates  (the  "2017  Counterparties")  entitling  the  Company  to  purchase  up  to  9,553,096  shares  of  the  Company's 
common stock at an initial stock price of $42.13 per share, each of which is subject to adjustment. The cost of the 2017 Hedge was 
$80.1  million  and  accounted  for  as  derivative  assets  upon  issuance  of  the  Notes.  Upon  approval  of  stockholders  on  issuance  of 
additional authorized shares, the derivative asset was reclassified to stockholders' equity, resulted in recognizing cumulatively $37.1 
million in other expense for the change in fair value measurement and $43.0 million in additional paid-in-capital during 2011. The 
2017 Hedge will expire on July 1, 2017. The 2017 Hedge is expected to reduce the potential equity dilution upon conversion of the 
2017 Notes if the daily volume-weighted average price per share of the Company's common stock exceeds the strike price of the 2017 
Hedge. An assumed exercise of the 2017 Hedge by the Company is considered anti-dilutive since the effect of the inclusion would 
always be anti-dilutive with respect to the calculation of diluted earnings per share. 

2017 Warrants 

The Company sold warrants to the 2017 Counterparties to acquire up to 477,654 shares of the Company's Series A Participating 
Preferred Stock at an initial strike price of $988.51 per share,  subject to adjustment. Each share of Series A Participating Preferred 
Stock is convertible into 20 shares of the Company's common stock, or up to 9,553,080 common shares in total. The 2017 Warrants 
will expire on various dates from September 2017 through January 2018 and may be settled in cash or net shares. It is the Company's 
current intent and policy to settle all conversions in shares of the Company’s common stock. The Company received $47.9 million in 
cash proceeds from the sale of the 2017 Warrants, which was recorded in additional paid-in-capital. The 2017 Warrants could have a 
dilutive  effect  on  the  Company's  earnings  per  share  to  the  extent  that  the  price  of  the  Company's  common  stock  during  a  given 
measurement  period  exceeds  the  strike  price  of  the  2017  Warrants.  The  Company  uses  the  treasury  share  method  for  assumed 
conversion of its 2017 Warrants to compute the weighted average common shares outstanding for diluted earnings per share. 

7.    Commitments  

Leases 

The Company leases office facilities and equipment under various operating and capital lease agreements. The initial terms of 
these leases range from 1 year to 15 years and generally provide for periodic rent increases and renewal options. Certain leases require 
the Company to pay taxes, insurance and maintenance. In connection with certain operating leases, the Company has security deposits 
recorded and maintained as restricted cash totaling $5.6 million as of December 31, 2015. 

Rent expense is recognized on a straight-line basis over the term of the lease. Accordingly, rent expense recognized in excess of 
rent paid is reflected as a liability in the accompanying Consolidated Balance Sheets. Rent expense, including costs directly associated 
with  the  facility  leases,  was  approximately  $9.3  million,  $11.5  million,  and  $12.0  million  for  the  years  ended  December 31,  2015, 
2014, and 2013, respectively.  

88 

 
 
 
 
The  Company’s  future  minimum  annual  lease  payments  under  capital  and  operating  leases,  including  payments  for  costs 

directly associated with the facility leases, for years ending after December 31, 2015 are as follows (in thousands):  

2016 
2017 
2018 
2019 
2020 
Thereafter 
Total minimum lease payments 
Less amount representing interest 
Present value of obligations under capital leases 
Less current portion 
Long-term capital lease obligations 

Capital 
Leases 

   Operating 

Leases 

9,701  
9,278  
6,640  
6,430  
6,478  
17,111  
55,638  

554    $ 
162      
20      
—      
—      
—      
736    $ 
(41)      
695        
(521)      
174        

  $

  $

  $

Licensing and Purchasing Agreements  

The Company is contingently obligated to make additional payments of up to $18.2 million in cash if specified future events 
occur or conditions are met as provided in certain consulting, purchase and/or product develop agreements. Not all of the respective 
agreements  specify  milestone  payment  timelines.  The  Company  has  also  entered  into  certain  consulting  arrangements  that  require 
payment of up to 264,000 shares (the equivalent value of approximately $14.3 million based on the closing price of our stock as of 
December 31, 2015) in the Company’s common stock. These agreements expire on various dates through 2024. 

Executive Employment Agreements 

 The  Company  has  employment  contracts  with  key  executives  that  provide  for  the  continuation  of  salary  if  terminated  for 
reasons  other  than  cause,  as  defined  in  those  agreements.  Certain  agreements  call  for  payments  which  are  based  on  historical 
compensation,  accordingly,  the  amount  of  the  contractual  commitment  will  change  over  time  commensurate  with  the  executive’s 
applicable  earnings. At  December 31,  2015,  future  employment  contract  commitments  for  such key  executives  were  approximately 
$22.1 million. In certain circumstances, the employment agreements call for the acceleration of equity vesting. Those figures are not 
reflected in the above information. 

8.    Stockholders’ Equity  

Common Stock 

There were 120,000,000 shares of common stock authorized at December 31, 2015 and 2014. 

Preferred Stock 

There are 5,000,000 shares of preferred stock authorized and none issued or outstanding at December 31, 2015 and 2014.  

On  June 28,  2011,  in  connection  with  the  issuance  of  the  2017  Warrants,  the  Company  amended  its  Restated  Certificate  of 
Incorporation  to  designate  477,654  shares  of  the  Company’s  authorized  preferred  stock,  par  value  $0.001  per  share,  as  Series  A 
Participating Preferred Stock (the “Series A Preferred Stock”). The Series A Preferred Stock will automatically convert into shares of 
the Company’s common stock.  The holders of Series A Preferred Stock (collectively, the Preferred Holders) are entitled to receive 
dividends when and if declared by the Board of Directors. The preferred dividends are payable in preference and in priority to any 
dividends  on  the  Company’s  common  stock.  Shares  of  Series  A  Preferred  Stock  are  convertible  into  20  shares  of  common  stock, 
subject  to  certain  anti-dilution  adjustments.  Preferred  Holders  vote  on  an  equivalent  basis  with  common  stockholders  on  an  as-
converted basis.    The  Preferred  Holders  are  entitled  to  receive  liquidation  preferences at  the  rate  of $648.20 per  share.  Liquidation 
payments to the Preferred Holders have priority and are made in preference to any payments to the holders of common stock.  

89 

 
 
  
 
 
 
  
 
 
  
 
   
   
   
   
   
   
 
   
 
   
 
 
  
 
Stock-based Compensation 

In  March  2014,  the  Compensation  Committee  (the  "Compensation  Committee")  of  the  Board  of  Directors  of  the  Company 
adopted  the  2014  Equity  Incentive  Plan  of  NuVasive,  Inc.  (the  "2014  EIP"),  replacing  the  2004  Amended  and  Restated  Equity 
Incentive Plan (the “2004 EIP”). No further awards may be granted under the 2004 EIP; however, that plan continues to govern all 
awards previously issued under it (many of which remain outstanding).  The 2014 EIP provides the Company with the ability to grant 
various types of equity awards to its workforce (including, without limitation, restricted stock units (“RSUs”), restricted stock awards, 
performance awards, and deferred stock awards). The 2014 EIP also provides for the issuance of performance RSUs (“PRSUs”) to be 
granted  subject  to  time-  and/or  performance-based  vesting  requirements.  In  addition,  the  award  agreements  under  the  2014  EIP 
generally  provide  for  the  acceleration  of  50%  of  the  unvested  equity  awards  of  all  shareowners  upon  a  change  in  control  and  the 
vesting of the remaining unvested equity awards for those shareowners that are involuntarily terminated within a year of the change in 
control. 

Each of the 2004 EIP and the 2014 EIP allow for “net share settlement” of certain equity awards whereby, in lieu of (i) making 
cash payments in satisfaction of the exercise price owed respective to non-qualified stock option awards, or (ii) open market selling 
award  shares  to  generate  cash  proceeds  for  use  in  satisfaction  of  statutory  tax  obligations  respective  to  an  award’s  settlement  or 
exercise, the company offsets the award shares being settled in a respective transaction by the number of shares of company stock with 
a value equal to the respective obligation, and, in the case of taxes, making a cash payment to the respective taxing authority on behalf 
of the shareowner using Company cash. The net share settlement is accounted for with the cost of any award shares that are net settled 
being included in treasury stock and reported as a reduction in total equity at the time of settlement. 

The  compensation  cost  that  has  been  included  in  the  statement  of  operations  for  our  stock-based  compensation  plans  was  as 

follows (in thousands):  

Sales, marketing and administrative expense 
Research and development expense 
Cost of goods sold 

Stock-based compensation expense before taxes 

Related income tax benefits 

  $

Stock-based compensation expense, net of taxes 

  $

Year Ended December 31, 

2015 

2014 

2013 

24,817    $
1,157     
229     
26,203     
(10,481)   
15,722    $

31,514     $ 
1,841       
332       
33,687       
(13,475 )     
20,212     $ 

31,425 
1,649 
166 
33,240 
(13,296)
19,944  

As of December 31, 2015, there was $13.5 million and $25.1 million of unrecognized compensation expense for RSUs and 
PRSUs, respectively, which is expected to be recognized over a weighted-average period of approximately 1.8 years and 3.3 years, 
respectively. In addition, as of December 31, 2015, there was $0.7 million of unrecognized compensation expense for shares expected 
to be  issued under  the  ESPP  which  is  expected  to  be  recognized  through April  2016. There was no unamortized expense  for  stock 
options as of December 31, 2015. 

The benefits of tax deductions in excess of recognized compensation cost is required to be reported as a financing cash flow. 
Excess  tax  benefits  of  $15.2  million,  $11.9  million,  and  $13.6  million  were  reported  as  financing  cash  flows  for  the  years  ended 
December 31, 2015, 2014, and 2013, respectively. 

Restricted Stock Units 

The total fair value of RSUs that vested during the year ended December 31, 2015, 2014, and 2013 was $39.0 million, $27.5 

million and $10.4 million, respectively.  

Following is a summary of RSU activity for the year ended December 31, 2015 (in thousands, except per share amounts):  

   Number of 

Shares 

   Weighted 
Average 

   Grant Date 
   Fair Value 

2,066    $ 
361      
(833)    
(245)    
1,349    $ 

24.99  
47.92  
23.41  
28.52  
31.82  

Nonvested at December 31, 2014 
Granted 
Vested 
Forfeited 
Nonvested at December 31, 2015 

90 

 
 
  
  
 
 
  
 
   
    
 
   
   
   
   
 
  
    
  
 
 
  
    
  
 
  
 
  
 
 
  
  
 
 
   
   
   
   
   
For  the  majority  of  RSUs,  shares  are  issued  on  the  vesting  dates  net  of  the  amount  of  shares  needed  to  satisfy  statutory  tax 
withholding requirements to be paid by the Company on behalf of the employees. The total shares withheld related to vested RSUs 
were approximately 330,000 and 29,000 in 2015 and 2014, respectively, and were based on the value of the awards on their vesting 
dates as determined by the Company’s closing stock price. Total payments for the employees’ tax obligations to the taxing authorities 
related to vesting RSUs were $15.4 million and $1.1 million in 2015 and 2014, respectively. No shares were withheld from vesting 
RSUs in 2013. 

Performance-Based Restricted Stock Units 

The  Company  has  granted  PRSUs  since  2012  for  which  the  ultimate  issuance  amount  is  determined  by  the  Company’s 
Compensation Committee upon its certification of Company performance against a pre-determined matrix, including revenue targets, 
total  shareholder  return,  or  earnings  per  share  over  pre-determined  periods  of  time.  Share  payout  levels  range  from  0  to  250% 
depending on the respective terms of an award. Based upon the company’s actual performance against the performance conditions, 
approximately  117,000  shares  of  common  stock  vested  on  each  of  March 1,  2013,  March  1,  2014,  and  March  1,  2015  for  PRSUs 
granted in 2012, and approximately 470,000 shares of common stock vested on each of February 1, 2014 and February 1, 2015 for 
PRSUs granted in 2013, in each case in the aggregate for all award recipients. On February 1, 2016, based upon the company’s actual 
performance against the performance conditions, approximately 102,000 shares of common stock vested for PRSUs granted in 2014. 

In  2015,  the  Company  granted  a  PRSU  award  with  five  year  cliff  vesting  terms  to  its  Chief Executive  Officer  for  which  the 
performance criteria was not based on Company specific performance metrics, and as such, the Company records the award as a long-
term liability as expensed over the service period. No amounts have been paid out on this award, or are expected to become due until 
2020. 

The  total  fair  value  of  performance  awards  vested  during  2015,  2014,  and  2013  was  $27.1  million,  $21.6  million  and  $2.3 

million, respectively.   

Following is a summary of PRSU activity for the year ended December 31, 2015 (in thousands, except per share amounts):  

Outstanding at December 31, 2014 
Awarded at target 
Achieved in excess of target 
Vested 
Forfeited 
Outstanding at December 31, 2015 

727    
607    
95    
(588)  
(38)  
803    

  Maximum Number        
of Shares Eligible 
to be Issued 

Shares 

Average Grant
Date Fair Value
18.51
48.34
36.39
18.52
37.29
46.42  

936     $ 
1,093       
—       
(588 )     
(84 )     
1,357     $ 

For the majority of PRSUs, shares are issued on the vesting dates net of the amount of shares needed to satisfy statutory tax 
withholding requirements to be paid by the Company on behalf of the employees. The total shares withheld related to vesting PRSUs 
were  approximately 292,000  in  2015,  and  were  based  on  the  value  of  the  awards  on  their  vesting  dates  as  determined  by  the 
Company’s closing stock price. Total payments for the employees’ tax obligations to the taxing authorities related to vesting PRSUs 
were $13.5 million in 2015. No shares were withheld from vesting PRSUs in each of 2014 and 2013. 

Stock Options 

The Company has not granted any stock options since 2011. The stock options previously granted are exercisable for a period of 

up to ten years after the date of grant. 

The aggregate intrinsic value of outstanding stock options at December 31, 2015 is based on the Company’s closing stock price 
on December 31, 2015 of $54.11. The Company received $6.2 million, $17.5 million and $3.4 million in proceeds from the exercise of 
stock  options  during  the  years  ended  December 31,  2015,  2014  and  2013,  respectively.  The  total  intrinsic  value  of  stock  options 
exercised was $63.4 million, $17.6 million, and $2.0 million during the years ended December 31, 2015, 2014 and 2013, respectively. 
The  total  fair  value  of  stock  options  that  vested  during  the  year  ended  December 31,  2015,  2014  and  2013  was  $0.3  million,  $3.5 
million, and $6.8 million, respectively. 

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Following  is  a  summary  of  stock  option  activity  for  the  year  ended  December 31,  2015  under  all  stock  plans  (in  thousands, 

except years and per share amounts): 

Outstanding at December 31, 2014 

Exercised 
Cancelled 

Outstanding at December 31, 2015 
Exercisable at December 31, 2015 
Vested or expected to vest at December 31, 2015 

Weighted-
Average 

  Weighted 
  Avg. Exercise  
Price 

   Remaining 
   Contractual        Aggregate 
Intrinsic 
Value 

Term 
(Years) 

Shares 

5,286    $
(3,295)    
(21)    
1,970     
1,970    $
1,970    $

32.11   
30.49        
23.08        
34.91      
34.91      
34.91      

3.88      $

79,594 

2.99      $
2.99      $
2.99      $

37,820 
37,820 
37,820  

  For the majority of stock options, shares are issued on the exercise dates net of the amount of shares needed to satisfy each of 
the exercise price (in lieu of cash) and statutory tax withholding requirements, the latter to be paid by the Company on behalf of the 
employee.  The  total  shares  withheld  related  to  exercised  stock  options  were  approximately 2,461,000  and  205,000 in  2015  and 
2014, respectively, and were based on the value of the stock options on their exercise dates as determined by the Company’s closing 
stock  price.  Total  cash  payments  for  the  employees’  tax  obligations  to  the  taxing  authorities  related  to  exercised  stock  options 
were $28.0 million and $2.7 million, in 2015and 2014, respectively. No shares were withheld from exercised stock options in 2013. 

Employee Stock Purchase Plan 

The  NuVasive,  Inc.  2004  Amended  and  Restated  Employee  Stock  Purchase  Plan  (the  “ESPP”),  provides  eligible  employees 
with  a  means  of  acquiring  equity  in  the  Company  at  a  discounted  purchase  price  using  their  own  accumulated  payroll  deductions. 
Under the terms of the ESPP, employees can elect to have up to 15% of their annual compensation, up to a maximum of $21,250 per 
year, withheld to purchase shares of Company common stock for a purchase price equal to 85% of the lower of the fair market value 
per  share  (at  closing)  of  Company  common  stock  on  (i)  the  commencement  date  of  the  two-year  or  six-month  offering  period 
(depending  on  the  purchase  period  enrolled)  or  (ii)  the  respective  purchase  date.  In  the  years  ended  December 31,  2015,  2014  and 
2013, 209,000, 268,000, and 417,000 shares, respectively, were purchased under the ESPP. 

The weighted average assumptions used to estimate the fair value of stock options granted and stock purchase rights under the 

ESPP are as follows:  

ESPP 

Volatility 
Expected term (years) 
Risk free interest rate 
Expected dividend yield 

 Common Stock Reserved for Future Issuance 

Year Ended December 31, 
2014 

2013 

2015 

40%   
1.2    
0.2%   
—%   

46 %     
1.3      
0.2 %     
— %     

55%
1.5  
0.2%
—%

The  following  table  summarizes  common  shares  reserved  for  issuance  on  exercise  or  conversion  at December 31,  2015  (in 

thousands): 

Issued and outstanding stock options 
Issued and outstanding RSUs and PRSUs 
Available for issuance under the ESPP 
Available for future grant 
2017 Notes 
2017 Warrants 
Total shares reserved for future issuance 

1,970 
2,423 
1,549 
1,359 
12,419 
19,106 
38,826  

Pursuant to the terms of the 2014 Equity Incentive Plan, shares subject to awards granted under the 2004 Amended and Restated 
Equity Incentive Plan may be utilized for future grants of awards under the 2014 Equity Incentive Plan, to the extent such awards are 
terminated,  cancelled  or  they  expire,  or  shares  subject  thereto  are  withheld  to  cover  taxes.    As  the  number  of  these  shares  is 
indeterminate, these shares have not been registered for issuance, nor are they reflected in the number of shares available for future 
grant. 

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9.    Income Taxes  

Total income (loss) before income taxes summarized by region for the years ended December 31 is as follows (in thousands):  

United States 
Foreign 
Total income (loss) before income taxes 

Year Ended December 31, 

2015 
128,489    $
(16,470)   
112,019    $

  $

  $

2014 

2013 

11,462     $ 
(22,672 )     
(11,210 )   $ 

8,818 
950 
9,768  

The income tax provision (benefit) for the years ended December 31 consists of the following (in thousands):   

Current: 

Federal 
State 
Foreign 

Total current provision 

Deferred: 

Federal 
State 
Foreign 

Total deferred provision 

Changes in tax rate 
Changes in valuation allowance 

Total provision 

Year Ended December 31, 

2015 

2014 

2013 

  $

  $

1,480    $
178     
2,090     
3,748     

42,719     
4,433     
(698)   
46,454     
266     
(3,739)   
46,729    $

32,387     $ 
3,359       
2,259       
38,005       

(28,604 )     
(2,296 )     
(1,528 )     
(32,428 )     
(84 )     
793       
6,286     $ 

10,484 
2,718 
922 
14,124 

(7,042)
(2,074)
(1,829)
(10,945)
— 
(396)
2,783  

The differences between the income tax provision at the United States federal statutory tax rate and the Company’s effective tax 

rate for the years ended December 31 are the following (in thousands):   

Tax provision at federal statutory rate 
Globalization initiative 
State income tax (benefit) 
Valuation allowance 
Income tax reserves 
Compensation expense 
Income tax credits and incentives 
Non-deductible meals and entertainment 
Foreign earnings taxed as non-United States rates 
Other 

Total provision 

Year Ended December 31, 

2015 

2014 

2013 

  $

  $

39,207    $
9,039     
4,264     
(3,739)   
2,301     
(2,115)   
(1,754)   
638     
(494)   
(618)   
46,729    $

(3,923 )   $ 
9,244       
827       
793       
657       
1,428       
(2,198 )     
521       
(199 )     
(864 )     
6,286     $ 

3,419 
— 
(222)
(396)
285 
1,052 
(1,668)
343 
205 
(235)
2,783  

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Significant components of the Company’s deferred tax assets and liabilities at December 31 are composed of the following (in 

thousands):   

Deferred tax assets: 

Litigation and related accrual 
Share-based compensation 
Inventory 
Net operating loss carryforwards 
General business and other credit carryforwards 
Deferred rent 
Other 
Gross deferred tax assets 
Less valuation allowance 
Net deferred tax assets 

Deferred tax liabilities: 

Depreciation 
Original issue discount 
Acquired intangibles 
Other 

Total deferred tax liabilities 
Consolidated net deferred tax assets 

Add deferred tax liability, net, attributable to non-controlling interests 

Net deferred tax assets 

December 31, 

2015 

2014 

34,054      $
23,641       
13,344       
3,484       
5,425       
5,154       
14,739       
99,841       
(7,290 )     
92,551       

(24,361 )     
(1,090 )     
(295 )     
(1,278 )     
(27,024 )     
65,527      $
897       
66,424      $

66,307 
36,104 
9,988 
6,638 
4,336 
5,354 
12,417 
141,144 
(11,026)
130,118 

(19,642)
(1,629)
(293)
— 
(21,564)
108,554 
1,681 
110,235   

   $

   $

   $

The following table summarizes the activity related to our unrecognized tax benefits (in thousands):  

Year Ended December 31, 

2015 

2014 

2013 

Gross unrecognized tax benefits at January 1 
Increases in tax positions for prior years 
Decreases in tax positions for prior years 
Increases in tax positions for current year relating to ongoing 
operations 
Gross unrecognized tax benefits at December 31 

  $

12,372  $
2,614     
(3,156)   

4,504     $ 
5,294       
-       

618     
12,448    $

2,574       
12,372     $ 

  $

4,399 
92 
- 

13 
4,504  

Included in the gross uncertain tax benefits balance at December 31, 2015 are $0.4 million of tax deductions for which there is 
uncertainty  only  regarding  the  timing  of  the  tax  benefit.    In  the  event  these  deductions  are  deferred  to  a  later  period,  it  would 
accelerate the payment of cash to the taxing authority.  Other than potential interest and penalties, such deferral would have no impact 
on tax expense.  At December 31, 2015, 2014, and 2013, $7.2 million, $7.2 million, and $3.2 million, respectively, of the Company’s 
total unrecognized tax benefits, if recognized, would affect the effective income tax rate.  

In  accordance  with  the  disclosure  requirements  as  described  in  ASC  Topic  740,  Income  Taxes,  the  Company  has  classified 
uncertain tax positions as non-current income tax liabilities unless expected to be paid in one year. The Company’s continuing practice 
is to recognize interest and/or penalties related to income tax matters in income tax expense. For the years ended December 31, 2015, 
the  Company  recognized  approximately  $0.1  million  in  interest  and  penalties  as  income  tax  expense  (benefit)  in  the  Consolidated 
Statement  of  Operations.  The  Company  did  not  recognize  any  interest  and  penalties  in  2014  and  2013.  The  Company  had 
approximately $0.1 million for the payment of interest and penalties accrued at December 31, 2015 in the Consolidated Balance Sheet 
and no amounts accrued for payment of interest and penalties accrued at December 31, 2014. 

The Company does not anticipate there will be a significant change in unrecognized tax benefits within the next 12 months. 

The  Company  is  subject  to  routine  compliance  reviews  on  various  tax  matters  around  the  world  in  the  ordinary  course  of 
business. Currently, income tax audits are being conducted in the state of New York and the state of Louisiana. U.S. and most foreign 
jurisdictions remain subject to examination in all years due to prior year net operating losses and R&D credits. 

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The  Company  does  not  record  U.S.  income  taxes  on  the  undistributed  earnings  of  its  foreign  subsidiaries  based  upon  the 
Company’s  intention  to  indefinitely  reinvest  undistributed  earnings  to  ensure  sufficient  working  capital  and  further  expansion  of 
existing  operations  outside  the  United  States.  The  undistributed  earnings  of  the  foreign  subsidiaries  as  of  December  31,  2015  are 
immaterial.  In  the  event  the  Company  is  required  to  repatriate  funds  from  outside  of  the  United  States,  such  repatriation  would  be 
subject to local laws, customs, and tax consequences. 

Under  ASC  Topic  718,  Compensation—Equity  Compensation,  the  fair  value  of  share-based  compensation  is  required  to  be 
recognized as an expense, and the excess tax benefit associated with such compensation will continue to be credited to additional paid-
in-capital, but only to the extent the excess tax benefits have not already been recognized in the consolidated statement of operations. 
The excess tax benefit associated with employee stock plans were approximately $11.6 million, $11.9 million and $13.6 million for 
2015, 2014 and 2013, respectively. 

The  Company  recognizes  excess  tax  benefits  associated  with  share-based  compensation  to  stockholders’  equity  only  when 
realized. When assessing whether excess tax benefits relating to share-based compensation have been realized, the Company follows 
the with-and-without approach excluding any indirect effects of the excess tax deductions. Under this approach, excess tax benefits 
related to share-based compensation are not deemed to be realized until after the utilization of all other tax benefits available to the 
Company.  During  the  year  ended  December  31,  2015,  the  Company  realized  $11.6  million  of  such  excess  tax  benefits,  and 
accordingly recorded a corresponding credit to additional paid-in capital. As of December 31, 2015, the Company had $18.0 million 
of  unrealized  excess  tax  benefits  associated  with  share-based  compensation.  These  tax  benefits  will  be  accounted  for  as  a  credit  to 
additional paid-in capital, if and when realized, rather than a reduction of the provision for income taxes. 

At  December 31,  2015,  the  Company  had  $38.4 million,  $54.2  million  and  $9.2 million  of  federal,  state  and  foreign  net 

operating loss carryforwards, respectively, which will begin to expire in 2018, 2016, and 2018, respectively. 

There were also federal and state research & development income tax credit carryforwards of $5.8 million and $11.3 million, 
respectively.  The  federal  credits  will  begin  to  expire  in  2019.  The  state  credits  can  be  carried  forward  indefinitely.  A  valuation 
allowance of $8.3 million was recorded against the state credits due to uncertainty surrounding their realization. 

Due to the “change of ownership” provision of the Tax Reform Act of 1986, utilization of the Company’s net operating loss and 
credit  carryforwards  may  be  subject  to  an  annual  limitation  against  taxable  income  in  future  periods.  As  a  result  of  any  future 
ownership  changes,  the  annual  limitation  of  loss  and  credit  carryforwards  may  cause  them  to  expire  before  ultimately  becoming 
available to reduce future income tax liabilities.  

10.    Business Segment, Product and Geographic Information  

The Company operates in one segment based upon the Company’s organizational structure, the way in which the operations and 
investments are managed and evaluated by the chief operating decision maker (“CODM”) as well as the lack of availability of discrete 
financial information at a lower level. The Company’s CODM reviews revenue at the product line offering level, and manufacturing, 
operating income and expenses, and net income at the Company wide level to allocate resources and assess the Company’s overall 
performance.  The  Company  shares  common,  centralized  support  functions,  including  finance,  human  resources,  legal,  information 
technology,  and  corporate  marketing,  all  of  which  report  directly  to  the  CODM.  Accordingly,  decision-making  regarding  the 
Company’s  overall  operating  performance  and  allocation  of  Company  resources  is  assessed  on  a  consolidated  basis.  As  such,  the 
Company operates as one reporting segment. The Company has disclosed the revenues for each of its product line offerings to provide 
the reader of the financial statements transparency into the operations of the Company. 

The Company reports under two distinct product lines for revenue; spine surgery products, and biologics. The Company’s spine 
surgery  products  line  offerings,  which  include  thoracolumbar  product  offerings,  cervical  product  offerings,  IOM  services  and 
disposables are primarily used to enable access to the spine and to perform restorative and fusion procedures in a minimally disruptive 
fashion. The Company’s biologics product line offerings includes allograft (donated human tissue), FormaGraft (a collagen synthetic 
product), Osteocel Plus and Osteocel Pro (each an allograft cellular matrix containing viable mesenchymal stem cells, or MSCs), and 
AttraX (a synthetic bone graft material), all of which are used to aid the spinal fusion or bone healing process. 

Revenue by product line offerings was as follows:  

(in thousands) 
Spine Surgery Products 
Biologics 
Total Revenue 

Year Ended December 31, 

2015 
678,891    $
132,222     
811,113    $

2014 
632,845     $ 
129,570       
762,415     $ 

2013 
569,540 
115,633 
685,173  

  $

  $

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Revenue and property and equipment, net, by geographic area were as follows:  

Revenue 
Year Ended December 31, 

      Property and Equipment, Net

December 31, 

(in thousands) 
United States 
International (excludes Puerto Rico) 
Total 

11.    Contingencies  

2015 
714,768    $
96,345     
811,113    $

2014 
667,850    $
94,565     
762,415    $

  $

  $

2015 

2013 
620,363      $  112,581    $
28,860     
685,173      $  141,441    $

64,810        

2014 
105,022 
23,543 
128,565   

The  Company  is  subject  to  potential  liabilities  under  government  regulations  and  various  claims  and  legal  actions  that  are 
pending or may be asserted from time-to-time. These matters arise in the ordinary course and conduct of the Company’s business and 
include,  for  example,  commercial,  intellectual  property,  environmental,  securities,  and  matters  involving  our  employees  and  sales 
representatives.  The  Company  intends  to  continue  to  defend  itself  vigorously  in  such  matters.  Furthermore,  the  Company  regularly 
assesses contingencies to determine the degree of probability and range of possible loss for potential accrual in its financial statements. 
In the first quarter of 2015, the Company had a gain of $56.4 million related to a litigation accrual change resulting from the legal 
proceedings in Phase 1 of the Medtronic litigation whereby the damages award by the jury was overturned, and a gain of $2.8 million 
in litigation accrual change related to settlement of the NeuroVision trademark litigation. These amounts were offset by a litigation 
charge of $13.8 million related to the Office of the Inspector General of the U.S. Department of Health and Human Services (“OIG”) 
investigation  and  $3.6  million  in  general  litigation  matters.  Refer  to  the  subsequent  section  herein  titled  “Legal  Proceedings”  for 
further information. 

Legal Proceedings  

Medtronic Sofamor Danek USA, Inc. Litigation  

In  August  2008,  Warsaw  Orthopedic,  Inc.,  Medtronic  Sofamor  Danek  USA,  Inc.  and  other  Medtronic  related  entities 
(collectively,  “Medtronic”)  filed  a  patent  infringement  lawsuit  against  the  Company  in  the  United  States  District  Court  for  the 
Southern District of California (the “Medtronic Litigation”), alleging that certain of the Company’s products or methods, including the 
XLIF® procedure, infringe, or contribute to the infringement of, twelve U.S. patents assigned or licensed to Medtronic. Three of the 
patents were later withdrawn by Medtronic, leaving nine purportedly infringed patents. The Company brought counterclaims against 
Medtronic alleging infringement of certain of the Company’s patents.  

The case has been administratively broken into several phases.  

The first phase (“Phase 1”) of the case included three Medtronic patents and one Company patent. The initial trial on the first 
phase  of  the  case  concluded  on  September  20,  2011  in  the  U.S.  District  Court  for  the  Southern  District  of  California,  and  a  jury 
delivered an unfavorable verdict against the Company with respect to the three Medtronic patents and a favorable verdict with respect 
to the one Company patent at issue, including a monetary damages award of approximately $101.2 million to Medtronic (the “2011 
verdict”). Medtronic’s subsequent motion for a permanent injunction was denied by the District Court. On May 15, 2013, the District 
Court  granted  the  parties’  joint  motion  to  dismiss  claims  relating  to  one  of  the  three  Medtronic  patents  pursuant  to  a  settlement 
agreement, leaving two Medtronic patents remaining in the litigation. On June 11, 2013, the District Court granted the parties ongoing 
royalties with respect to the two Medtronic patents and the one Company patent remaining in the first phase of the case (the “June 
2013 ruling”).  

Both parties filed appeals to the U.S. Court of Appeals for the Federal Circuit. On March 2, 2015, the Court of Appeals issued a 
decision  upholding  the  jury’s  findings  of  liability  as  to  all  patents,  but  overturning  the  damage  award  against  the  Company  as 
improper (“March 2nd Court of Appeals Decision”). The case has been remanded back to the District Court for further proceedings to 
determine a proper damages award, and a retrial has not been scheduled. As a result of the affirmation of the infringement and remand 
for a new trial on damages, the Company assessed the existing liability under the loss contingency framework and – in accordance 
with  applicable  accounting  guidance  –  believes  the  most  appropriate  accrual  estimate  within  the  possible  range  dictated  by  such 
guidance is $87.6 million. This amount represents liability for the infringement of the two Medtronic patents for infringing products at 
historically supplied rates from the date of infringement to the current period. The liability does not include an accrual for lost profits 
or convoyed products. A liability associated with this matter has been recorded in non-current litigation liabilities. In prior periods, the 
Company  recorded  the  respective  liabilities  (as  estimated)  in  non-current  litigation  liabilities  and  the  accrued  royalties  in  accrued 
liabilities.  The  Company  does  not  agree  with  the  previously-ruled  royalty  rates,  and  intends  to  rigorously  pursue  appropriate  rates 
during  the  new  trial  on  damages.  Nonetheless,  in  the  interim,  the  Company  has  applied  the  previously-ruled  royalty  rates  when 
calculating the appropriate estimate. As a result of the adjustment, the Company recorded an adjustment of $56.4 million as a gain in 
its Consolidated Statements of Operations during the year ended December 31, 2015. 

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On  March 19, 2012,  in  connection with  these  proceedings,  the  Company  entered  into  an  escrow  arrangement  and  transferred 
$113.3 million of cash into a restricted escrow account to secure the amount of judgment, plus prejudgment interest, during pendency 
of the appeal. As a result of the March 2nd Court of Appeals Decision, the parties agreed to release all of the escrow funds related to 
this  matter  back  to  the  Company.  During  the  year  ended  December  31,  2015,  the  Company  transferred  all  of  the  funds  in  escrow 
related to this matter, approximately $114.1 million, from long-term restricted cash and investments into its unrestricted investment 
accounts. 

In accordance with the authoritative guidance on the evaluation of loss contingencies, during the year ended December 31, 2011, 
the Company recorded an accrual of $101.2 million for the 2011 verdict. In addition, the Company accrued royalties at the royalty 
rates stated in the 2011 verdict on sales subsequent to the 2011 verdict and through March 31, 2013. After the June 2013 ruling, the 
Company (i) began accruing ongoing royalties on sales at the royalty rates stated in the June 2013 ruling, and (ii) recorded a charge of 
approximately $7.9 million to account for the difference between using the royalty rates stated in the 2011 verdict and those in the 
June 2013 ruling on sales through March 31, 2013. Based on the June 2013 ruling, the Company agreed to escrow funds to secure 
accrued royalties as well as future ongoing royalties. However, in light of the March 2nd Court of Appeals Decision, escrowed funds 
have been released to the Company and, absent a court order the Company is no longer required to escrow such funds until damages 
are ultimately determined. Additionally, the Company has modified its accrual from the 2011 verdict as a result of the March 2nd Court 
of Appeals Decision as previously discussed. 

With  respect  to  the  favorable  verdict  delivered  regarding  the  one  Company  patent  litigated  to  verdict,  the  jury  awarded  the 
Company  monetary  damages  of  approximately  $0.7  million  for  reasonable  royalty  damages.  In  accordance  with  the  authoritative 
guidance on the evaluation of gain contingencies, this amount has not been recorded at December 31, 2015. Additionally, the June 
2013 ruling determined the ongoing royalty rate to be paid to the Company by Medtronic for its post-verdict sales of the one Company 
patent. Consistent with the treatment afforded the $0.7 million damage award, no amount has been recorded for royalty revenue as of 
December 31, 2015. 

The  second phase  of  the  case  involved one Medtronic  cervical  plate  patent. On April 25, 2013,  the Company  and Medtronic 
entered  into  a  settlement  agreement  fully  resolving  the  second  phase  of  the  case.  The  settlement  also  removed  from  the  case  the 
cervical plate patent that was part of the first phase. As part of the settlement, the Company received a broad license to practice (i) the 
Medtronic patent that was the sole subject of the second phase of the litigation, (ii) the Medtronic cervical plate patent that was part of 
the  first  phase  of  the  litigation,  and  (iii)  each  of  the  Medtronic  patent  families  that  collectively  represent  the  vast  majority  of 
Medtronic’s  patent  rights  related  to  cervical  plate  technology.  In  exchange  for  these  license  rights,  the  Company  made  a  one-time 
payment to Medtronic of $7.5 million, which amount will be fully offset against any damage award ultimately determined to be owed 
by the Company in connection with a final resolution of the first phase of the litigation. In addition, Medtronic will receive a royalty 
on  certain  cervical  plate  products  sold  by  the  Company,  including  the  Helix®  and  Gradient®  lines  of  products.  As  a  result  of  this 
settlement, all current patent disputes between the parties related to cervical plate technology have been resolved. 

In August 2012, Medtronic filed additional patent claims in the U.S. District Court for the Northern District of Indiana alleging 
that  various  Company  spinal  implants  (including  its  CoRoent® XL family  of  spinal  implants)  infringe  Medtronic’s U.S.  Patent  No. 
8,021,430, that the Company’s Osteocel Plus bone graft product infringes Medtronic’s U.S. Patent No. 5,676,146, (“146 Patent”) and 
that  the  Company’s  XLIF  procedure  and  use  of  MaXcess  IV  retractor  during  the  XLIF  procedure  infringe  methodology  claims  of 
Medtronic’s U.S. Patent No. 8,251,997. The case, which is referred to herein as the third phase of the Medtronic litigation, was later 
transferred  to  the  Southern  District  of  California,  and,  on  March  7,  2013,  the  Company  counterclaimed  alleging  infringement  by 
Medtronic of the Company’s U.S. Patent Nos. 8,000,782 (systems and related methods for performing surgical procedures), 8,005,535 
(systems and related methods for performing surgical procedures), 8,016,767 (a surgical access system including a tissue distraction 
assembly and a tissue retraction assembly), 8,192,356 (a system for accessing a surgical target site and related methods, involving an 
initial distraction system, among other things), 8,187,334 (spinal fusion implant), 8,361,156 (spinal fusion implant), D652,922 (dilator 
design)  (“922  Patent”),  and  D666,294  (dilator  design).  On  July  25,  2013,  Medtronic  amended  its  complaint  to  add  a  charge  of 
infringement of its U.S. Patent No. 8,444,696. The District Court has stayed litigation of a number of Medtronic and Company patents 
currently subject to reexamination or review proceedings conducted by the Patent Office. Both parties brought motions for summary 
judgment  addressing  the  remaining  patents,  and  Medtronic’s  motion  was  granted,  but  the  District  Court  has  not  yet  issued  a  final 
decision regarding the Company motion. On October 20, 2015, the District Court issued an opinion granting Medtronic’s motion for 
summary judgment of non-infringement of the ‘922 Patent. The District Court has not yet issued decisions regarding the Company’s 
dispositive motions with respect to the ‘146 Patent. No trial date has been set in this third phase of the litigation. At December 31, 
2015,  the  probable  outcome  of  this  litigation  cannot  be  determined,  nor  can  the  Company  estimate  a  range  of  potential  loss.  In 
accordance with the authoritative guidance on the evaluation of loss contingencies, the Company has not recorded an accrual related to 
this litigation. 

97 

 
 
Trademark Infringement Litigation  

On September 25, 2009, Neurovision Medical Products, Inc. (NMP) filed suit against the Company in the U.S. District Court for 
the  Central  District  of  California  (Case  No. 2:09-cv-06988-R-JEM)  alleging  trademark  infringement  and  unfair  competition.  NMP 
sought  cancellation of  NuVasive’s “NeuroVision”  trademark  registrations,  injunctive  relief  and  damages  based on NMP’s  common 
law use of the “NeuroVision” mark. The matter was tried in October 2010 and an unfavorable jury verdict was delivered against the 
Company.  The  verdict  awarded  damages  to  NMP  of  $60.0  million.  NuVasive  appealed  the  judgment,  and  during  pendency  of  the 
appeal, NuVasive was required to escrow funds totaling $62.5 million. In September 2012, the Court of Appeals reversed and vacated 
the judgment and ordered the case back to the District Court for a new trial before a different judge.  As a result, the full $62.5 million 
was released from escrow and returned to the Company. Retrial of the matter began on March 25, 2014, and on April 3, 2014, a jury 
returned  a  verdict  in  favor  of  NMP  on  its  claims  against  the  Company  in  the  amount  of  $30.0  million. On  September  4,  2014,  the 
Company filed a notice of appeal.  The Court entered judgment and ordered a permanent injunction on September 24, 2014, enjoining 
the Company’s future use of the NeuroVision trademark to market or promote its products. The Court also entered an order canceling 
the Company’s NeuroVision trademark registrations, but that order was stayed pending the appeal process. On December 2, 2014, the 
Court denied NMP’s motion for attorneys’ fees, costs, and prejudgment interest, and NMP filed a notice of appeal on December 17, 
2014. The  appeals  were  consolidated  on  February  2,  2015.  Subsequent  to  June  30,  2015,  but  prior  to  the  filing  of  the  Company’s 
second quarter Form 10-Q filing, the Company agreed to settle all outstanding matters with NMP for $27.2 million, and on August 25, 
2015, the District Court vacated the judgment, as well as its orders canceling the NeuroVision trademarks and dissolved the injunction. 
The Company adjusted its litigation accrual from $30.0 million to $27.2 million at June 30, 2015, which was recorded in short-term 
liabilities commensurate with the restricted assets. The $2.8 million gain resulting from the litigation accrual adjustment was recorded 
in the Consolidated Statement of Operations during the second quarter 2015. The Company previously escrowed funds totaling $32.5 
million  to  secure  the  amount  of  judgment,  and  cover  potential  attorney’s  fees  and  costs.  Those  funds  accrued  interest  and  were 
included  in  short-term  restricted  cash  and  investments  in  the  Consolidated  Balance  Sheets  until  funding  of  the  settlement  which 
occurred during the third quarter 2015. At December 31, 2015, the Company had no remaining liability or restricted cash related to 
this matter. 

Securities Litigation  

On August 28, 2013, a purported securities class action lawsuit was filed in the U.S. District Court for the Southern District of 
California  naming  the  Company  and  certain  of  its  current  and  former  executive  officers  for  allegedly  making  false  and  materially 
misleading  statements  regarding  the  Company’s  business  and  financial  results,  specifically  relating  to  the  purported  improper 
submission of false claims to Medicare and Medicaid. The complaint asserts a putative class period stemming from October 22, 2008 
to July 30, 2013. The complaint alleges violations of Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, 
and Rule 10b-5 promulgated thereunder and seeks unspecified monetary relief, interest, and attorneys’ fees. On February 13, 2014, the 
lead plaintiff (“Plaintiff”) filed an Amended Class Action Complaint for Violations of the Federal Securities Laws. The District Court 
granted  the  Company’s  motion  to  dismiss  the  Amended  Complaint  and  ordered  Plaintiff  to  amend  its  complaint.  Plaintiff  filed  a 
Second Amended Complaint on September 8, 2014, and the District Court once again granted the Company’s motion to dismiss the 
complaint with leave to amend. On December 23, 2014 Plaintiff filed a Third Amended Complaint.  The Company filed a motion to 
dismiss,  and  while  the  Company’s  motion  was  pending,  Plaintiff  sought  leave  to  file  a  Fourth  Amended  Complaint. The  Company 
moved to dismiss the Fourth Amended Complaint. On August 28, 2015, the District Court issued an order granting the Company’s 
motion  to  dismiss  the  Fourth  Amended  Complaint  with  leave  to  amend.  On  September  11,  2015,  Plaintiff  filed  a  Fifth  Amended 
Complaint  and  the  Company  subsequently  filed  a  motion  to  dismiss.  The  Court  has  not  yet  ruled  on  the  Company’s  motion.  At 
December 31, 2015, the probable outcome of this litigation cannot be determined, nor can the Company estimate a range of potential 
loss.  In  accordance  with  authoritative  guidance  on  the  evaluation  of  loss  contingencies,  the  Company  has  not  recorded  an  accrual 
related to this litigation. 

12.    Regulatory Matters  

In  2013,  the  Company  received  a  federal  administrative  subpoena  from  the  Office  of  the  Inspector  General  of  the  U.S. 
Department of Health and Human Services (OIG) in connection with an investigation into possible false or otherwise improper claims 
submitted to Medicare and Medicaid. In April 2015, the Company announced that it had reached an agreement in principle with the 
U.S.  Department  of  Justice  (“DOJ”)  to  settle  this  matter,  and  in  July  2015,  the  Company  entered  into  a  definitive  settlement 
agreement.  Under  the  terms  of  the  agreement,  the  Company  agreed  to  pay  $13.5  million  plus  fees  and  accrued  interest  of 
approximately $0.3 million to resolve this matter. The settlement was not an admission of liability or wrongdoing by the Company, 
and the Company was not required to enter into a corporate integrity agreement with the OIG as part of the settlement. In accordance 
with the authoritative guidance on the evaluation of loss contingencies, the Company recorded a $13.8 million litigation charge related 
to this matter, which is included in the Consolidated Statements of Operations during the year ended December 31, 2015, and funded 
the $13.8 million settlement during the year ended December 31, 2015. 

98 

 
 
 
On  August  31,  2015,  the  Company  received  a  civil  investigative  demand  (“CID”)  issued  by  the  DOJ  pursuant  to  the  federal 
False Claims Act. The CID requires the delivery of a wide range of documents and information related to an investigation by the DOJ 
concerning allegations that the Company assisted a physician group customer in submitting improper claims for reimbursement and 
made improper payments to the physician group in violation of the Anti-Kickback Statute. The Company is cooperating with the DOJ. 
No  assurance  can  be  given  as  to  the  timing  or  outcome  of  this  investigation.  At  December  31,  2015,  the  probable  outcome  of  this 
matter cannot be determined, nor can the Company estimate a range of potential loss. In accordance with authoritative guidance on the 
evaluation of loss contingencies, the Company has not recorded an accrual related to this matter. 

13.    Subsequent Events 

Acquisition of Ellipse Technologies, Inc. 

On January 4, 2016, the Company entered into a definitive agreement to acquire Ellipse Technologies for an upfront payment of 
$380.0  million  at  the  closing  and  a  potential  milestone  payment  of  $30.0  million  payable  in  2017  related  to  the  achievement  of 
specific  revenue  targets.  The  closing  of  the  acquisition  occurred  on  February  11,  2016,  and  Ellipse  Technologies  is  now  a  wholly-
owned subsidiary of the Company. In connection with the closing, the Company used approximately $380.0 million of its available 
cash and investments on hand to pay the upfront payment to security holders of Ellipse Technologies, as well as related transaction 
fees  and  expenses.  Ellipse  Technologies  offers  magnetically  adjustable  implant  systems  based  on  the  MAGnetic  External  Control 
(“MAGEC”), technology platform. 

Revolving Senior Credit Facility 

In February 2016, the Company entered into a Credit Agreement (the “Credit Agreement”) for a revolving senior credit facility 
(the “Facility”) that provides for secured revolving loans, multicurrency loan options and letters of credit in an aggregate amount of up 
to  $150.0  million.  The  Credit  Agreement  also  contains  an  expansion  feature,  which  allows  the  Company  to  increase  the  aggregate 
principal amount of the Facility provided the Company remains in compliance with the underlying financial covenants. The Facility 
expires in February 2021. 

Borrowings  under  the  Facility  are  used  by  us  to  provide  financing  for  working  capital  and  other  general  corporate  purposes, 
including potential mergers and acquisitions. Loans under the Facility bear interest, at the option of the Company, at either LIBOR 
(determined in accordance with the Credit Agreement) plus an applicable margin ranging from 1.00 % - 2.00 % per annum subject to 
Company’s  applicable  consolidated  leverage  ratio or  the Base  Rate (determined  in  accordance with  the  Credit  Agreement), plus  an 
applicable margin ranging from 0.0% - 1.25% per annum subject to Company’s applicable consolidated leverage ratio. The Facility 
has a commitment fee, which accrues at a rate of 0.2% - 0.4% per annum (determined in accordance with the Credit Agreement) based 
on the Company’s current leverage ratio. 

The Credit Agreement contains affirmative, negative and financial covenants, and events of default customary for financings of 
this type. The financial covenants require the Company to maintain ratios of consolidated earnings before interest, taxes, depreciation 
and  amortization  (EBITDA)  to  consolidated  interest  expense,  and  to  consolidated  debt,  respectively,  as  defined  in  the  Credit 
Agreement, at varying scales throughout the life of the Credit Agreement. The Facility grants the lenders preferred first priority liens 
and security interests in capital stock, intercompany debt and all of the present and future property and assets of the Company and 
each guarantor. 

14.    Quarterly Data (unaudited)  

The following quarterly financial data, in the opinion of management, reflects all adjustments, consisting of normal recurring 

adjustments necessary, for a fair presentation of results for the periods presented (in thousands, except per share amounts):  

Total revenues 
Gross profit 

Consolidated net income 

  $

Net income attributable to NuVasive, Inc. 
Basic net income per common share attributable to NuVasive, Inc.    
Diluted net income per common share attributable to NuVasive, 
Inc. 

Year Ended December 31, 2015 

First 
Quarter (1)

Second 
Quarter

Third 
Quarter 

Fourth 
Quarter

192,383    $
146,719     
31,397     
31,560     
0.66     

202,910      $ 
154,495        
10,040        
10,268        
0.21     

200,538    $
151,371     
12,750     
12,960     
0.26     

215,282 
164,049 
11,103 
11,503 
0.23 

0.61     

0.20     

0.24     

0.22   

99 

 
 
 
 
   
  
 
 
  
 
    
     
    
 
   
   
   
   
Total revenues 
Gross profit 
Consolidated net income (loss) 
Net income (loss) attributable to NuVasive, Inc. 
Basic net income (loss) per common share attributable to 
NuVasive, Inc. 
Diluted net income (loss) per common share attributable to 
NuVasive, Inc. 

Year Ended December 31, 2014 

First 
Quarter (2)

Second 
Quarter (3)

Third 
Quarter 

Fourth 
Quarter

  $

177,496    $
134,202     
(18,533)    
(18,276)    

190,677      $ 
145,841        
(4,270 )      
(4,088 )      

189,918    $
142,199     
(1,987)    
(1,830)    

204,324 
157,815 
7,292 
7,473 

(0.40)    

(0.09 )      

(0.04)    

(0.40)    

(0.09 )      

(0.04)    

0.16 

0.15   

(1)  Consolidated financial results include a litigation liability gain of $56.4 million stemming from a favorable appeal in Phase 1 of 

the Medtronic litigation, and a litigation liability loss of $13.8 million in connection with the OIG investigation. 

(2)  Consolidated  financial  results  include  a  litigation  liability  charge  of  $30.0  million  representing  the  reasonably  estimated 

probable loss related to an unfavorable jury verdict.  

(3)  Consolidated  financial  results  include  a  intangible  assets  impairment  charge  of  $10.7  million  related  to  the  developed 

technology acquired from Cervitech in 2009. 

100 

 
 
 
  
 
 
  
 
    
     
    
 
   
   
   
 
 
 
 
 
 
 
 
NuVasive, Inc.  

Schedule II: Valuation Accounts  

(In thousands)  

Inventory Reserve 
Year ended December 31, 2015 
Year ended December 31, 2014 
Year ended December 31, 2013 

Balance at 
Beginning of  Period   

Additions 
Charged to 
Expense (1) 

Deductions or 
Others (2) 

Balance at 
End of  Period  

  $
  $
$

22,578    $
21,874    $
16,856    $

20,705     $ 
11,425     $ 
10,003     $ 

14,821    $
10,721    $
4,985    $

28,462 
22,578 
21,874  

(1)  Amount represents excess and obsolete reserve recorded to cost of sales.  

(2)  Excess and obsolete inventory write-off against reserve or adjustment of reserve formerly established.  

101 

 
 
   
  
 
    
   
      
        
        
        
 
 
 
 
 
Exhibit  
Number 

3.1 

3.2 

3.3 

3.4 

4.1 

4.2 

4.3 

4.4 

10.1# 

10.2# 

10.3# 

10.4# 

10.5# 

10.6# 

10.7# 

10.8# 

10.9# 

10.10# 

10.11# 

Description

Restated Certificate of Incorporation (incorporated by reference to our Quarterly Report on Form 10-Q filed with the 
Commission on August 13, 2004) 

Certificate of Amendment to the Restated Certificate of Incorporation (incorporated by reference to our Current Report
on Form 8-K filed with the Commission on September 28, 2011) 

Restated  Bylaws  (incorporated  by  reference  to  our  Current  Report  on  Form 8-K  filed  with  the  Commission  on
January 6, 2012) 

Amendment No. 1 to the Restated Bylaws (incorporated by reference to our Current Report on Form 8-K filed with the 
Commission on May 19, 2014) 

Specimen  Common  Stock  Certificate  (incorporated  by  reference  to  our  Annual  Report  on  Form 10-K  filed  with  the 
Commission on March 16, 2006) 

Certificate  of  Designations  of  Series A  Participating  Preferred  Stock  filed  with  the  Delaware  Secretary  of  State  on
June 28, 2011 (incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 
2011) 

Indenture dated June 28, 2011 between the Company and U.S. National Association (incorporated by reference to our
Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Form of 2.75% Convertible Senior Note due 2017 (incorporated by reference to our Current Report on Form 8-K filed 
with the Commission on June 29, 2011) 

2004 Amended and Restated Equity Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q 
filed with the Commission on July 26, 2012) 

Amendment No. 1 to the 2004 Amended and Restated Equity Incentive Plan (incorporated by reference to our Annual
Report on Form 10-K filed with the Commission on March 3, 2014) 

Form  of  Stock  Option  Award  Notice  under  the  2004  Amended  and  Restated  Equity  Incentive  Plan  (incorporated  by
reference to Amendment No. 1 to our Registration Statement on Form S-1 filed with the Commission on April 8, 2004)

Form of Option Exercise and Stock Purchase Agreement under the 2004 Amended and Restated Equity Incentive Plan
(incorporated by reference to Amendment No. 1 to our Registration Statement on Form S-1 filed with the Commission 
on April 8, 2004) 

Form  of  Restricted  Stock  Unit  Award  Agreement  under  the  2004  Amended  and  Restated  Equity  Incentive  Plan
(incorporated by reference to our Annual Report on Form 10-K filed with the Commission on February 26, 2010) 

Form of Restricted Stock Grant Notice and Restricted Stock Agreement under the 2004 Amended and Restated Equity
Incentive Plan (incorporated by reference to Amendment No.1 to our Registration Statement on Form S-1 filed with the 
Commission on April 8, 2004) 

NuVasive,  Inc.  2004  Amended  and  Restated  Employee  Stock  Purchase  Plan  (incorporated  by  reference  to  our
Quarterly Report on Form 10-Q filed with the Commission on October 30, 2014) 

2014  Equity  Incentive  Plan (incorporated by  reference  to  Exhibit A  to  our  Definitive  Proxy  Statement  filed with the
Commission on March 27, 2014) 

Form  of  Performance  Restricted  Stock  Unit  Agreement  (with  accompanying  Form  Notice  of  Grant)  under  the  2014
Equity Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on
May 4, 2015) 

Form of Executive Restricted Stock Unit Agreement (with accompanying Form Notice of Grant) under the 2014 Equity
Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on May 4, 
2015) 

Form  of  Performance  Cash  Award  Agreement  (with  accompanying  Form  Notice  of  Grant)  under  the  2014  Equity
Incentive Plan (incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on May 4, 
2015) 

102 

 
 
 
   
 
 
 
  
 
 
  
 
 
  
 
 
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
   
 
 
 
 
 
 
 
 
 
 
Exhibit  
Number 

10.12# 

10.13# 

10.14# 

10.15# 

10.16# 

10.17# 

10.18# 

10.19# 

10.20# 

10.21# 

10.22# 

10.23# 

10.24# 

Description

Form of Performance Restricted Stock Unit Agreement (with accompanying Notice of Grant) for grants after February
11, 2016 under the 2014 Equity Incentive Plan 

Form  of  Executive  Restricted  Stock  Unit  Agreement  (with  accompanying  Form  Notice  of  Grant)  for  grants  after
February 11, 2016 under the 2014 Equity Incentive Plan 

Form of Performance Cash Award Agreement (with accompanying Form Notice of Grant) for grants after February 11,
2016 under the 2014 Equity Incentive Plan 

NuVasive, Inc. 2014 Executive Incentive Compensation Plan (incorporated by reference to Exhibit B to our Definitive
Proxy Statement filed with the Commission on March 27, 2014) 

Form  of  Indemnification  Agreement  between  the  Company  and  its  directors  and  certain  executives  thereof
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on May 19, 2014) 

NuVasive, Inc. Amended and Restated Executive Severance Plan (incorporated by reference to our Current Report on
Form 8-K filed with the Commission on August 6, 2015) 

Form of Change in Control Agreement between the Company and certain executives thereof (incorporated by reference
to our Current Report on Form 8-K filed with the Commission on May 19, 2014) 

NuVasive, Inc. Deferred Compensation Plan (incorporated by reference to our Current Report on Form 8-K filed with 
the Commission on August 6, 2015) 

Separation Agreement and Release dated March 27, 2015 between the Company and Alex V. Lukianov (incorporated
by reference to our Current Report on Form 8-K filed with the Commission on April 1, 2015) 

Consulting Agreement dated March 27, 2015 between the Company and Alex V. Lukianov (incorporated by reference
to our Current Report on Form 8-K filed with the Commission on April 1, 2015) 

Letter Agreement dated May 22, 2015 between the Company and Gregory T. Lucier (incorporated by reference to our
Current Report on Form 8-K filed with the Commission on May 26, 2015) 

Notice  of  Grant  of  Share  Purchase  Matching  Performance  Restricted  Stock  Units  and  Award  Agreement  granted  to 
Gregory  T.  Lucier  on  May  22,  2015  (incorporated  by  reference  to  our  Current  Report  on  Form  8-K  filed  with  the 
Commission on May 26, 2015) 

Notice  of  Grant  of  “Inducement”  Performance  Restricted  Stock  Units  and  Award  Agreement  granted  to  Gregory  T. 
Lucier on May 22, 2015 (incorporated by reference to our Current Report on Form 8-K filed with the Commission on
May 26, 2015) 

10.25# 

Non-Employee Director Cash Compensation Plan (incorporated by reference to our Annual Report on Form 10-K filed 
with the Commission on March 3, 2014) 

10.26 

10.27 

10.28 

10.29 

10.30 

10.31 

Lease  Agreement  for  Sorrento  Summit  dated  November 6,  2007  between  the  Company  and  HCPI/Sorrento,  LLC 
(incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on November 8, 2007) 

Confirmation for base call option transaction dated June 22, 2011 between the Company and Bank of America, N.A.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for additional call option transaction dated June 24, 2011, between the Company and Bank of America,
N.A. (incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for base call option transaction dated June 22, 2011 between the Company and Goldman, Sachs & Co.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for additional call option transaction dated June 24, 2011 between the Company and Goldman, Sachs &
Co. (incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation  for  base  warrant  transaction  dated  June 22,  2011  between  the  Company  and  Bank  of  America,  N.A.
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

103 

 
 
 
   
 
 
 
  
 
 
   
 
 
 
 
  
  
 
 
  
 
 
  
 
 
   
 
 
   
 
 
  
 
 
  
 
 
  
 
 
   
  
 
   
 
 
   
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
Exhibit  
Number 

10.32 

10.33 

10.34 

10.35 

10.36† 

10.37† 

10.38† 

21.1 

23.1 

31.1 

31.2 

32.1* 

Description

Confirmation for additional warrant transaction dated June 24, 2011 between the Company and Bank of America, N.A. 
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation  for  base  warrant  transaction  dated  June 22,  2011  between  the  Company  and  Goldman,  Sachs  &  Co. 
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Confirmation for additional warrant transaction dated June 24, 2011 between the Company and Goldman, Sachs & Co. 
(incorporated by reference to our Current Report on Form 8-K filed with the Commission on June 29, 2011) 

Preferred Stock Purchase Agreement dated January 13, 2009 among the Company, Progentix Orthobiology, B.V. and
the sellers listed on Schedule A thereto (incorporated by reference to our Annual Report on Form 10-K filed with the 
Commission on February 26, 2010) 

Option Purchase Agreement dated January 13, 2009 among the Company, Progentix Orthobiology, B.V. and the sellers
listed on Schedule A thereto (incorporated by reference to our Annual Report on Form 10-K filed with the Commission 
on February 26, 2010) 

Exclusive  Distribution  Agreement  dated  January 13,  2009  between  the  Company  and  Progentix  Orthobiology,  B.V.
(incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on May 8, 2009) 

Settlement and License Agreement dated April 25, 2013 among the Company, Medtronic Sofamor Danek USA, Inc.,
Warsaw Orthopedic, Inc., Medtronic Puerto Rico Operations Co. and Medtronic Sofamor Danek Deggendorf, GmbH
(incorporated by reference to our Quarterly Report on Form 10-Q filed with the Commission on July 30, 2013) 

List of subsidiaries of the Company 

Consent of Independent Registered Public Accounting Firm 

Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 
1934, as amended 

Certification  of  Chief  Financial  Officer  pursuant  to  Rule 13a-14(a)  and  15d-14(a)  of  the  Securities  Exchange  Act  of 
1934, as amended 

Certifications of the Chief Executive Officer and Chief Financial Officer pursuant to Rule 13a-14(b) of the Securities 
Exchange Act of 1934, as amended, and 18 U.S.C. section 1350 

101 

101 

101 

101 

101 

101 

† 

# 
* 

XBRL Instance Document 

XBRL Taxonomy Extension Schema Document 

XBRL Taxonomy Calculation Linkbase Document 

XBRL Taxonomy Label Linkbase Document 

XBRL Taxonomy Presentation Linkbase Document 

XBRL Taxonomy Definition Linkbase Document 

Certain confidential information contained in this exhibit was omitted by means of redacting a portion of the text and replacing 
it with an asterisk. We have filed separately with the Commission an unredacted copy of the exhibit.  
Indicates management contract or compensatory plan.  
These certifications are being furnished solely to accompany this annual report pursuant to 18 U.S.C. Section 1350, and are not 
being filed for purposes of Section 18 of the Securities Exchange Act of 1934 and are not to be incorporated by reference into 
any filing of NuVasive, Inc., whether made before or after the date hereof, regardless of any general incorporation language in 
such filing. 

104 

 
 
 
   
 
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
  
 
 
   
 
 
  
 
 
  
 
 
  
 
 
 
  
 
  
 
 
  
 
 
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NUVASIVE, INC. CORPORATE INFORMATION

EXECUTIVE OFFICERS:

Gregory T. Lucier
Chairman and  
Chief Executive Officer

Quentin S. Blackford
Executive Vice President and 
Chief Financial Officer

Carol A. Cox
Executive Vice President,  
External Affairs and  
Corporate Marketing 

BOARD OF DIRECTORS:

Gregory T. Lucier
Chairman and  
Chief Executive Officer 
NuVasive, Inc.

Jack R. Blair
Former Executive,  
Smith & Nephew plc

Vickie L. Capps
Former Chief Financial Officer, 
DJO Global, Inc.

Patrick S. Miles
President and  
Chief Operating Officer

Peter M. Leddy, Ph.D.
Executive Vice President,  
Corporate Integrity and  
Global Human Resources

Matthew W. Link
President,  
U.S. Commercial

Jason D. Hanson, Esq.
Executive Vice President,  
Strategy, Corporate Development and 
General Counsel

Edmund Roschak
Chief Executive Officer,  
NuVasive Specialized Orthopedics, Inc.

Jason M. Hannon, Esq.
Executive Vice President, 
International

Peter C. Farrell, Ph.D., AM
Founding Chairman and former  
Chief Executive Officer, ResMed, Inc.

Leslie V. Norwalk, Esq.
Strategic Advisor,  
Epstein Becker & Green, P.C. 

Robert F. Friel
Chairman, Chief Executive Officer and 
President, PerkinElmer, Inc.

Lesley H. Howe
Former Audit Partner, 
KPMG Peat Marwick LLP

Donald J. Rosenberg, Esq.
Executive Vice President, General 
Counsel and Corporate Secretary, 
Qualcomm Incorporated

Daniel J. Wolterman
President and Chief Executive Officer,
Memorial Hermann Health System

ANNUAL MEETING:

STOCK INFORMATION:

TRANSFER AGENT:

May 19, 2016 at 8:00 AM (local time) 
NuVasive, Inc.  
Corporate Headquarters 
7475 Lusk Boulevard,  
San Diego, CA 92121

NuVasive, Inc. common stock is  
listed on the NASDAQ – Global  
Select market (NASDAQ: NUVA)

Computershare  
P.O. Box 30170 
College Station, TX 77842 
Shareholder Services: 1-800-962-4284

FORWARD LOOKING STATEMENTS: The letter to shareholders and this annual report 
contain forward-looking statements that involve risks, uncertainties, assumptions and 
other factors which, if they do not materialize or prove correct, could cause our results 
to differ from historical results or those expressed or implied by such forward-looking 
statements. In some cases, you can identify these forward-looking statements by 
words like “may”, “will”, “should”, “could”, “expect”, “plan”, “anticipate”, “believes”, 
“estimates”, “predicts”, “potential”, “intends”, or “continues” (or the negative of those 
words and other comparable words). Forward-looking statements include, but are not 
limited to, statements about: our intentions, beliefs and expectations regarding our 
expenses, sales, operations and future financial performance; our operating results; our 
plans for future products and enhancements of existing products; and anticipated growth 
and trends in our business. These statements are not guarantees of future performance 
or events, and actual results may differ materially from those discussed herein. These and 
other risks and uncertainties are further described in our news releases and periodic filings 
with the Securities and Exchange Commission, including in Item 1(a) of our Annual Report 
on Form 10-K for the year ended December 31, 2015. NuVasive’s public filings with the 
Securities and Exchange Commission are available at www.sec.gov. NuVasive assumes 
no obligation to update any forward-looking statement to reflect events or circumstances 
arising after the date on which it was made.

NON-GAAP INFORMATION: The letter to shareholders and this annual report include 
financial information that is not calculated in accordance with GAAP. Non-GAAP operating 
profit margin and non-GAAP earnings per share are non-GAAP financial measures that 
exclude amortization of intangible assets, leasehold related charges, integration related 
expenses associated with acquired businesses, one-time restructuring and acquisition 
related items, CEO transition related costs, certain litigation charges and non-cash 
interest expense and or losses on convertible notes. Management also uses certain non-
GAAP financial measures that are intended to exclude the impact of foreign exchange 
currency fluctuations. The measure constant currency is the use of an exchange rate that 
eliminates fluctuations when calculating financial performance numbers. Management 
calculates these non-GAAP financial measures excluding these costs and uses these 
non-GAAP financial measures to enable it to further and more consistently analyze the 
period-to-period financial performance of its core business operations. Management 
believes that providing investors with these non-GAAP financial measures gives them 
additional information to enable them to assess, in the same way management assesses, 
the Company’s current and future continuing operations. These non-GAAP measures 
are not in accordance with, or an alternative for, GAAP, and may be different from non-
GAAP measures used by other companies. Reconciliations of these non-GAAP financial 
measures to the comparable GAAP financial measure can be found on the Investors tab of 
the Company’s website, www.nuvasive.com.

NuVasive, Inc. 
Corporate Headquarters
7475 Lusk Boulevard
San Diego, CA 92121

nuvasive.com