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Sientra

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FY2016 Annual Report · Sientra
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-K

(Mark One)

☒☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

☐☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2016

OR

Commission file number: 001-36709

SIENTRA, INC.
(Exact Name of Registrant as Specified in its Charter)

Delaware 
(State or Other Jurisdiction of Incorporation or Organization)

20-5551000 
(I.R.S. Employer Identification No.)

420 South Fairview Avenue, Suite 200, Santa Barbara, California 
(Address of Principal Executive Offices)

93117 
(Zip Code)

(805) 562-3500
(Registrant’s Telephone Number, Including Area Code)

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes  ☐   No  ☒

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes  ☐   No  ☒

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the
preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90
days.  Yes  ☒   No  ☐

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be
submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was
required to submit and post such files).  Yes  ☒   No  ☐

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§ 229.405 of this chapter) is not contained herein, and will not be
contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to
this Form 10-K. ☒

Indicate  by  check  mark  whether  the  registrant  is  a  large  accelerated  filer,  an  accelerated  filer,  a  non-accelerated  filer,  or  a  smaller  reporting  company.  See  the

definitions of “large accelerated filer”, “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer  ☐

Non-accelerated filer ☐
(Do not check if a smaller reporting company)
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐   No ☒

Accelerated filer ☒

Smaller reporting company ☐

The aggregate market value of registrant's common stock held by non-affiliates of the registrant, based upon the closing price of a share of the registrant's common stock
on June 30, 2016 as reported by NASDAQ Global Select Market on such date was approximately $65,626,788. Shares of the registrant's common stock held by each
executive  officer,  director  and  holder  of  5%  or  more  of  the  outstanding  common  stock  have  been  excluded  in  that  such  persons  may  be  deemed  to  be  affiliates.  This
determination of affiliate status is not necessarily a conclusive determination for other purposes.

As of March 9, 2017, there were 18,833,933 shares of the registrant’s common stock, par value $0.01 per share, outstanding.

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the registrant’s definitive Proxy Statement relating to its 2017 Annual Meeting of Stockholders are incorporated by reference into Part III of this Annual
Report on Form 10-K where indicated. Such Proxy Statement will be filed with the U.S. Securities and Exchange Commission within 120 days after the end of the fiscal
year to which this report relates.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Table of Contents

PART I  
Item 1 .
Item 1A .
Item 1B .
Item 2 .
Item 3 .
Item 4.  
PART II  
Item 5 .

Item 6 .
Item 7.  
Item 7A .
Item 8 .
Item 9 .
Item 9A .
Item 9B .
PART III  
Item 10 .
Item 11 .
Item 12 .
Item 13 .
Item 14 .
PART IV  
Item 15 .

Signatures

Business
Risk Factors
Unresolved Staff Comments
Properties
Legal Proceedings
Mine Safety Disclosures

Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity
Securities
Selected Financial Data
Management’s Discussion and Analysis of Financial Condition and Results of Operations
Quantitative and Qualitative Disclosures about Market Risk
Financial Statements and Supplementary Data
Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
Controls and Procedures
Other Information

Directors, Executive Officers, and Corporate Governance
Executive Compensation
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
Certain Relationships and Related Transactions and Director Independence
Principal Accountant Fees and Services

Exhibits, Financial Statements and Schedule

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SPECIAL NOTE REGARDING FORWARD‑‑LOOKING STATEMENTS

This  Annual  Report  on  Form  10‑K,  or  Annual  Report  contains  forward‑looking  statements  within  the  meaning  of
Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of
1934,  as  amended,  or  the  Exchange  Act.  Forward‑looking  statements  are  often  identified  by  the  use  of  words  such  as,
“anticipate,”  “believe,”  “may,”  “might,”  “could,”  “will,”  “aim,”  “estimate,”  “continue,”  “intend,”  “expect,”  “plan,”  or  the
negative  of  those  terms,  and  similar  expressions  that  convey  uncertainty  of  future  events  or  outcomes  to  identify  these
forward‑looking statements. These statements are based on the beliefs and assumptions of our management based on information
currently available to management. Forward‑looking statements in this Annual Report on Form 10‑K include, but are not limited
to, statements about:

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

the timing and availability of alternative manufacturing sources and our ability to supply our silicone gel breast implants,
tissue expanders and other products to our customers;

the success of our market reentry plan in light of limited inventory;

our ability to achieve profitability;

our ability to generate significant net sales through the sale of our silicone gel breast implants and other products;

the ability of our products to achieve and maintain market acceptance;

our ability to successfully commercialize our products;

our ability to comply with the applicable governmental regulations to which our products and operations are subject;

our ability to successfully integrate new products into our portfolio;

our ability to retain a high percentage of our customer base;

plans regarding the expansion of our sales force and marketing programs;

the productivity of our sales representatives and ability to achieve expected growth;

our assumptions about the breast implant market;

our ability to protect our intellectual property;

our ability to successfully defend against lawsuits filed against us and our officers; and

our estimates regarding expenses, net sales, capital requirements and needs for additional financing.

These forward‑looking statements involve risks and uncertainties as well as assumptions that, if they never materialize
or  prove  incorrect,  could  cause  our  results  to  differ  materially  from  those  expressed  or  implied  by  such  forward‑looking
statements.  Factors that could cause or contribute to such differences include, but are not limited to, those discussed in the section
titled “ Risk Factors ” included under Part I, Item 1A below. You should read these factors and the other cautionary statements
made  in  this  Annual  Report  as  being  applicable  to  all  related  forward-looking  statements  wherever  they  appear  in  this  Annual
Report.    We  caution  you  that  the  risks,  uncertainties  and  other  factors  referenced  above  may  not  contain  all  of  the  risks,
uncertainties and other factors that may impact the results and timing of certain events to differ materially from those expressed or
implied  in  forward-looking  statements.    In  addition,  we  cannot  guarantee  future  results,  level  of  activity,  performance  or
achievements. Any forward‑looking statement made by us in this Annual Report speaks only as of the date of this Annual Report.
Except  as  required  by  law,  we  undertake  no  obligation  to  update  any  forward‑looking  statements,  whether  as  a  result  of  new
information, future events or otherwise, after the date of such statements.

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Item 1.  Busines s

Overview

PART I

Sientra, Inc. (“Sientra”, the “Company,” “we,” “our” or “us”) is a medical aesthetics company committed to making a difference
in patients’ lives by enhancing their body image, growing their self‑esteem and restoring their confidence. We were founded to
provide  greater  choices  to  board‑certified  plastic  surgeons  and  patients  in  need  of  medical  aesthetics  products.  We  have
developed a broad portfolio of products with technologically differentiated characteristics, supported by independent laboratory
testing and strong clinical trial outcomes. We sell our breast implants and breast tissue expanders, or Breast Products, exclusively
to board‑certified and board‑admissible plastic surgeons and tailor our customer service offerings to their specific needs, which
we believe helps secure their loyalty and confidence. We have recently expanded our product portfolio through two acquisitions. 
We began selling bioCorneum®, an advanced silicone scar treatment directly to physicians after we acquired bioCorneum® from
Enaltus LLC, or Enaltus, in March 2016.  Additionally, we began selling the AlloX2®, and Dermaspan™ lines of breast tissue
expanders,  as  well  as  the  Softspan™  line  of  general  tissue  expanders,  after  we  acquired  these  product  lines  from  Specialty
Surgical Products, Inc., or SSP, in November 2016.

Our primary products are silicone gel breast implants for use in breast augmentation and breast reconstruction procedures, which
we  offer  in  approximately  400  variations  of  shapes,  sizes,  fill  volumes  and  textures.  Our  breast  implants  are  primarily  used  in
elective procedures that are generally performed on a cash‑pay basis. Many of our proprietary breast implants incorporate one or
more technologies that differentiate us from our competitors, including a High‑Strength Cohesive, or HSC, silicone gel and shell
texturing. Our breast implants offer a desired balance between strength, shape retention and softness due to the integration of our
silicone implant shell and  High‑Strength Cohesive silicone gel used in our implants. The texturing on Sientra’s implant shell is
designed to reduce the incidence of malposition, rotation and capsular contracture.

Our breast implants were approved by the U.S. Food and Drug Administration, or FDA, in 2012, based on data we collected from
our ongoing, long‑term clinical trial of our breast implants in 1,788 women across 36 investigational sites in the United States,
which included 3,506 implants (approximately 53% of which were smooth and 47% of which were textured). Our clinical trial is
the largest prospective, long‑term safety and effectiveness pivotal study of breast implants in the United States and includes the
largest  magnetic  resonance  imaging,  or  MRI,  cohort  with  571  patients.  The  MRI  cohort  is  a  subset  of  study  patients  that
underwent  regular  MRI  screenings  in  addition  to  the  other  aspects  of  the  clinical  trial  protocol  prior  to  FDA  approval.  Post-
approval,  all  patients  in  the  long-term  clinical  trial  are  subject  to  serial  MRI  screenings  as  part  of  the  clinical  protocol.  The
clinical data we collected over a nine‑year follow‑up period demonstrated rupture rates, capsular contracture rates and reoperation
rates that were comparable to or better than those of our competitors, at similar time points. In addition to our pivotal study, our
clinical data is supported by our Continued Access Study of 2,497 women in the United States. We have also commissioned a
number  of  bench  studies  run  by  independent  laboratories  that  we  believe  further  demonstrate  the  advantages  of  our  breast
implants over those of our competitors.

We sell our Breast Products exclusively to board‑certified and board‑admissible plastic surgeons, as determined by the American
Board of Plastic Surgery, who we refer to as Plastic Surgeons. These surgeons have completed the extensive multi‑year plastic
surgery  residency  training  required  by  the  American  Board  of  Plastic  Surgery.  While  aesthetic  procedures  are  performed  by  a
wide range of medical professionals, including dermatologists, otolaryngologists, obstetricians, gynecologists, dentists and other
specialists, the majority of aesthetic surgical procedures are performed by Plastic Surgeons. Plastic Surgeons are thought leaders
in  the  medical  aesthetics  industry.  According  to  the  American  Board  of  Plastic  Surgery,  there  are  approximately  6,500
board‑certified plastic surgeons in the United States. We seek to provide Plastic Surgeons with differentiated services, including
enhanced customer service offerings, a ten‑year limited warranty that we believe is the best in the industry based on: providing
patients  with  the  largest  cash  reimbursement  for  certain  out‑of‑pocket  costs  related  to  revision  surgeries  in  a  covered  event;  a
lifetime  no‑charge  implant  replacement  program  for  covered  ruptures;  and  our  industry‑first  CapCon  Care  Program,  or  C3
Program,  through  which  we  offer  no‑charge  replacement  implants  to  breast  augmentation  patients  who  experience  capsular
contracture within the first five years after implantation with our smooth or textured breast implants.

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We  commenced  sales  of  our  breast  implants  in  the  United  States  in  the  second  quarter  of  2012.  Our  net  sales  were
$20.7 million, $38.1 million and $44.7 million for the years ended December 31, 2016,  2015 and 2014, respectively. Our net loss
was $40.2 million, $41.2 million and $5.8 million for the years ended December 31, 2016,  2015 and 2014, respectively.

Between October 9, 2015 and March 1, 2016, we voluntarily suspended the sale of all Sientra devices manufactured by Silimed
Indústria de Implantes Ltda. (formerly, Silimed-Silicone e Instrumental Medico-Cirugio e Hospitalar Ltda.), or Silimed, due to
the suspension of Silimed’s CE and ISO 13485 certifications by TÜV SÜD, Silimed’s notified body under EU regulations.  This
was followed by Brazilian regulatory inquiries of Silimed and a suspension by the Brazilian regulatory agency ANVISA and the
Department  of  the  Secretary  of  State  of  Rio  de  Janeiro  of  the  manufacturing  and  shipment  of  all  medical  devices  made  by
Silimed, and their recommendation that plastic surgeons discontinue implanting the d evices until further notice. See Note 1(e) to
our Financial Statements for more information on the history of these developments with Silimed.  

After ongoing discussions with the FDA and our own review of the matter with the assistance of independent experts in
quality  management  systems,  current  Good  Manufacturing  Practices,  or  cGMP,  and  data-based  risk  assessment,  on  March  1,
2016,  we  lifted  the  temporary  hold  on  sales  .    We  also  informed  our  Plastic  Surgeons  of  our  controlled  market  re-entry  plan
designed to optimize our inventory supply , which continues to be limited as we finalize access to an alternative manufacturing
source.  

The events involving Silimed will likely continue to adversely impact our business, in particular due to the limitations on
our existing inventory levels , the uncertainty of our customers’ responsiveness to our controlled market re-entry plan , the fact
that Silimed filed a lawsuit against us alleging, among other things, a material breach of the existing manufacturing contract , and
the fact that the manufacturing contract with Silimed expires on its terms on April 1, 2017 .  See “Risk Factors — Risks Relating
to Our Business and Our Industry” for further detail. 

In  response  to  these  events  and  anticipated  impacts  on  our  business,  we  have  increasingly  focused  our  efforts  on

securing and qualifying an alternate manufacturing supplier.

On August 9, 2016, we announced our collaboration with Vesta Intermediate Funding, Inc., or Vesta, pursuant to which
we are working with Vesta towards establishing a dedicated contract manufacturing facility for our breast implants.  Vesta is a
Lubrizol LifeSciences Company and leading medical device contract manufacturer of silicone products and other medical devices
headquartered in Wisconsin. On March 14, 2017, we announced that we had executed a definitive manufacturing agreement with
Vesta  for  the  manufacture  and  supply  of  our  breast  implants.    In  addition,  on  March  14,  2017,  we  announced  that  we  had
submitted a pre‑market approval, or PMA, supplement to the FDA for the manufacturing of our PMA-approved breast implants
by Vesta. For further details, see Item 9B — “Other Information.”

We sell our products in the United States through a direct sales organization, which as of December 31, 2016, consisted

of 43 employees, including 36 sales representatives and 7 sales managers.

Our Market

The overall market for medical aesthetic procedures is significant, and awareness and acceptance of these procedures is
growing in the United States. According to the American Society for Aesthetic Plastic Surgery, or ASAPS, in 2015, consumers in
the  United  States  spent  approximately  $13.5  billion  on  aesthetic  procedures  overall,  including  both  surgical  and  non‑invasive
cosmetic treatments. Of this amount, more than $7.8 billion was spent on aesthetic surgical procedures.

Breast augmentation surgery remains the leading aesthetic surgical procedure by dollars and number of procedures in the
United States. According to ASAPS, over 305,000 primary breast augmentation procedures were performed in the United States
in 2015. These procedures provide cosmetic solutions generally to enhance breast size and shape, correct breast asymmetries or
help restore fullness after breastfeeding. For breast reconstruction, American Society of Plastic Surgeons, or ASPS, estimates that
approximately  106,000  procedures  were  performed  in  the  United  States  in  2015.  These  procedures  are  a  surgical  solution
generally used to restore a breast to near normal shape and appearance following a mastectomy and typically utilize a breast tissue
expander prior to implantation of a breast implant. Based on the number of procedures reported by ASAPS and by ASPS, and our
estimates of average selling price, implant mix and

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implants per procedure, we estimate that the U.S. market for breast implants and breast tissue expanders exceeded $635 million in
2015.  

Our Opportunity

We believe a significant opportunity exists in the U.S. marketplace due to the high barriers to entry in the U.S. breast

implant market and the historical lack of product and service innovation for Plastic Surgeons.

For more than 20 years prior to the FDA approval of our breast implants in 2012, only two companies manufactured and
distributed breast implants in the United States. We believe that this market concentration is largely a result of the considerable
costs  and  risks  associated  with  the  lengthy  regulatory  approval  process  required  by  the  FDA,  which  has  created  a  significant
barrier to entry in the U.S. breast implant market. All new breast implants require PMA approval from the FDA before they may
be  marketed  in  the  United  States.  The  PMA  application  process  is  lengthy  and  uncertain,  and  it  must  be  supported  by  valid
scientific  evidence,  which  typically  requires  long‑term  follow‑up  of  a  large  number  of  enrolled  patients,  as  well  as  extensive
pre‑clinical, clinical and other product data to demonstrate safety and effectiveness. We believe that in the near term, it is likely
that the companies currently providing silicone gel breast implants in the United States will continue to be the only companies
servicing the U.S. silicone breast implant market.

We  believe  the  rigorous  FDA  approval  process  and  the  existence  of  only  two  competitors  in  the  U.S.  market  have
historically  contributed  to  a  lack  of  technological  innovation  in  the  U.S.  breast  implant  industry  resulting  in  limited  product
choices. Until the FDA approval of our breast implants in 2012, surgeons in the United States were only able to purchase basic
round  breast  implants  from  our  two  U.S.  competitors,  while  surgeons  outside  of  the  United  States  were  able  to  purchase
technologically‑advanced round and anatomically‑shaped breast implants.

Our Competitive Strengths

We  believe  that  we  are  well  positioned  to  take  advantage  of  opportunities  afforded  by  current  market  dynamics.  By
focusing on products with technologically differentiated characteristics, demonstrating strong clinical data, offering more product
choices and providing services tailored specifically to the needs of Plastic Surgeons, we believe we can enhance our position in
the breast implant market. Our competitive strengths include:

Differentiated silicone gel and texturing technologies.  We incorporate differentiated technologies into our proprietary
breast implants to distinguish ourselves from our competitors, including our silicone shell, High‑Strength Cohesive silicone gel
and a textured surface. Our breast implants offer a desired balance between strength, shape retention and softness due to the High-
Strength Cohesive silicone gel used in our products. In addition, the texturing on Sientra’s implant shell is designed to reduce the
incidence of malposition, rotation and capsular contracture.

Strong clinical trial outcomes.  Our clinical trial results demonstrate the safety and effectiveness of our breast implants.
Our breast implants were approved by the FDA based on data we collected from our ongoing, long‑term clinical trial of our breast
implants  in  1,788  women  across  36  investigational  sites  in  the  United  States.  The  clinical  data  we  collected  over  a  nine-year
follow-up  period  demonstrated  rupture  rates,  capsular  contracture  rates  and  reoperation  rates  that  were  comparable  to  or  better
than those of our competitors, based on our competitors’ published nine-year data.

Innovative services that deliver an improved customer experience.  Our Breast Product customer service offerings are
intended  to  accommodate  and  anticipate  the  needs  of  Plastic  Surgeons  so  they  can  focus  on  providing  better  services  to  their
patients. We provide a ten‑year limited warranty that we believe is the best in the industry based on: providing patients with the
largest cash reimbursement for certain out‑of‑pocket costs related to revision surgeries in a covered event; a lifetime no‑charge
implant  replacement  program  for  covered  ruptures;  and  our  industry‑first  C3  Program  through  which  we  offer  no‑charge
replacement  implants  to  breast  augmentation  patients  who  experience  capsular  contracture  within  the  first  five  years  after
implantation  with  our  smooth  or  textured  breast  implants.  We  also  offer  specialized  educational  initiatives  and  a  streamlined
ordering, shipping and billing process.

Board‑‑certified plastic surgeon focus.  We sell our Breast Products exclusively to board‑certified and board‑admissible
plastic  surgeons  who  are  thought  leaders  in  the  medical  aesthetics  industry.  We  address  the  specific  needs  of  Plastic  Surgeons
through continued product innovation, expansion of our product portfolio and enhanced customer service offerings. We believe
that  securing  the  loyalty  and  confidence  of  Plastic  Surgeons  is  essential  to  our  success  and  that  our  association  with  Plastic
Surgeons enhances our credibility and aligns with our focus on making a difference in patients’ lives.

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Proven and experienced leadership team.  We have a highly experienced management team at both the corporate and
operational levels with significant experience in the medical aesthetics industry. Members of our senior management team have
extensive experience in the medical aesthetics industry.

Our Strategy

Our objective is to become a leading global provider of differentiated medical aesthetic products and services tailored to
meet the needs of physicians, allowing us to deliver on our commitment to enhance and make a difference in patients’ lives. We
are  mainly  focused  on  the  breast  implant  and  breast  tissue  expander  markets  and  our  share  of  them  in  the  United  States,  and
intend to continue to leverage our capabilities into new or complementary aesthetic products or technologies and new geographic
markets or market segments. To achieve our objective, we are pursuing the following business strategies:

Create  awareness  of  our  differentiated  technologies,  products  and  services  with  Plastic  Surgeons  and  consumers.
 Since we commenced commercial operations, we have focused most of our marketing efforts on Plastic Surgeons to promote and
create  awareness  of  the  benefits  of  our  products.  Among  other  marketing  programs  targeted  at  Plastic  Surgeons,  we  offer
educational  initiatives  exclusively  to  Plastic  Surgeons  through  our  Sientra  Education  Forums,  and  we  have  continued  our
consumer-directed  efforts,  including  an  exclusive  collaboration  with  RealSelf.com.    We  believe  that  continuing  to  invest  in
expanding marketing initiatives will have a positive impact on our business.

Selectively  pursue  acquisitions  and  expand  into  new  markets.   We  may  continue  to  selectively  pursue  domestic  and
international acquisitions of businesses or technologies that may allow us to leverage our relationships with Plastic Surgeons and
our  existing  commercial  infrastructure  to  provide  us  with  new  or  complementary  products  or  technologies,  and  allow  us  to
compete  in  new  geographic  markets  or  market  segments  or  to  increase  our  market  share.  For  example,  we  began  selling
bioCorneum®  directly  to  physicians  after  we  acquired  bioCorneum®  from  Enaltus  in  March  2016.  We  began  selling  the
AlloX2®  and  Dermaspan™  lines  of  breast  tissue  expanders,  and  the  Softspan™  line  of  general  tissue  expanders,  after  we
acquired these product lines from SSP in November 2016.

Broaden our product portfolio and launch new products and services.  We plan to continue to develop products that
address  the  unmet  needs  of  Plastic  Surgeons  and  patients  by  leveraging  our  innovative  technologies  in  combination  with  our
regulatory  and  product  development  expertise.  We  have  a  number  of  new  Breast  Products  under  development  with  different
characteristics and configurations. We believe these expanded product choices will allow Plastic Surgeons to potentially achieve
better outcomes for their patients.

Enhance our sales capabilities and marketing programs to drive adoption of our products.  We intend to increase our
direct  sales  capabilities  through  the  hiring  of  additional,  experienced  sales  representatives  and  support  staff.  We  believe  that
continued expansion of our sales team will allow us to broaden our market reach and educate a broader group of Plastic Surgeons
on the benefits of our products.

Invest  in  clinical  studies  and  peer  reviewed  articles  with  key  opinion  leaders.   We  intend  to  continue  to  invest  in
clinical  studies  in  order  to  provide  published  peer  reviewed  articles  that  support  the  clinical  benefits  of  our  products  and
technologies  over  those  of  our  competitors.  We  believe  our  relationship  with  Plastic  Surgeons  and  our  continued  focus  on
providing differentiated products and services will allow us to leverage our existing capabilities to increase our share of the breast
implant market specifically and the medical aesthetics market generally.

Our Products

Our  portfolio  of  products  has  been  specifically  tailored  to  the  needs  of  the  physicians  we  serve.  We  believe  that  our
broad portfolio of products with technologically differentiated characteristics enable Plastic Surgeons to deliver better outcomes
for their patients.

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Breast Augmentation and Breast Reconstruction Products

Our Breast Products are comprised of breast implants and breast tissue expanders.

Breast Implants.  We offer the following breast implants:

·

·

·

·

Anatomically‑shaped  textured.    A  full  line  of  textured,  anatomically‑shaped  HSC+  breast  implants,  all  of  which
incorporate  our  High‑Strength  Cohesive  silicone  gel  and  a  textured  surface.  Our  anatomically‑shaped  implants  are
engineered  for  shape  retention  and  feature  a  gradual  upper‑pole  slope  and  distributed  volume  that  mimics  the
characteristics of a natural breast. They also provide a desired balance between strength, shape retention and softness and
are designed to enhance tissue adherence to reduce malposition and capsular contracture. Due to the unique relationship
between our implant gel and our implant shells, our anatomically‑shaped implants have enhanced ability to retain their
shape without sacrificing the desired softness. We offer these anatomically‑shaped implants in three base configurations:
Round  Base,  Classic  Base  and  Oval  Base.  Our  Round  Base  implants  are  available  in  one  projection  profile  and  eight
volumes, our Classic Base implants are available in one projection profile and eight volumes and our Oval Base implants
are available in three projection profiles and 25 volumes. Additionally, in the fourth quarter of 2016, we received FDA
approval  of  84  new  anatomically-shaped  devices,  a  205%  increase  of  our  anatomically-shaped  portfolio.  Our  Round
Base implants were approved with an additional projection and 28 new sizes, our Classic Base implants were approved
with an additional projection and 32 new sizes and our Oval Base implants were approved with an additional 24 sizes.

Round  textured.    A  full  line  of  textured,  round  HSC  breast  implants,  all  of  which  incorporate  our  High‑Strength
Cohesive silicone gel and textured surface technology. Our textured, round implants maintain softness and are designed
to enhance tissue adherence that reduces malposition and capsular contracture. We offer these textured, round implants
in three projection profiles: Low, Moderate Plus and High. Our Low projection implants are available in 15 volumes, our
Moderate  Plus  projection  implants  are  available  in  22  volumes  and  our  High  projection  implants  are  available  in  16
volumes. Additionally, in the fourth quarter of 2016, we received approval of an additional projection and 52 more sizes.

Round smooth.  A full line of smooth, round HSC breast implants, all of which incorporate our High‑Strength Cohesive
silicone gel. Our smooth, round implants are designed to deliver full upper‑pole aesthetic results without compromising
softness.  We offer  these smooth, round implants  in five  projection  profiles:  Low, Moderate,  Moderate  Plus, Moderate
High and High. Additionally, in the fourth quarter of 2016, we received FDA approval of 8 more sizes.

Breast Tissue Expanders.  We offer a full line of breast tissue expanders, marketed as AlloX2® and Dermaspan™ in 52
different shapes and sizes. Our AlloX2 is the first and only breast tissue expander with access to the periprosthetic space,
with  its  patented  technology,  addressing  fluid  accumulation  that  can  lead  to  postoperative  complications.  Our  breast
tissue expanders are temporary devices used in breast reconstruction and implanted during or after the completion of a
mastectomy  and  intended  to  aid  in  the  process  of  recreating  tissue  coverage  to  allow  for  the  placement  of  the  final
implant to reconstruct the breast.

Scar Management Products

We offer bioCorneum®, the only advanced scar treatment with a patented crosslinking silicone technology, Silishield™, plus the
protection of SPF 30. bioCorneum® acts as a quick drying, silicone gel that creates an invisible, breathable and flexible silicone
sheet over scars. It is a clinically proven silicone scar technology that prevents and minimizes the formation of hypertrophic and
keloid  scars,  decreases  the  appearance  of  old  scars,  and  helps  to  restore  the  function  of  healthy  skin.  The  SPF  30  provides
protection  from  the  sun  to  reduce  the  sun’s  darkening  effects  on  scars.  The  patented  gel  helps  to  safeguard  against  chemical,
microbial, and physical detriments while improving the cosmetic appearance of scar tissue by binding with the stratum corneum
(the  outer  layer  of  skin  cells).  bioCorneum®  decreases  transepidermal  water  loss  and  increases  the  production  of  fibroblast
growth factor  to heal skin and prevent  abnormal  scarring.  Additionally,  we offer bioCorneum® with Hydrocortisone  to relieve
itching.

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Other Products

We also offer a range of other aesthetic products that have received 510(k) clearance from the FDA, including:

·

·

temporary,  single‑use,  saline‑filled  breast  implant  sizers  that  can  be  used  to  help  identify  the  correct  style  and  size
implant for an individual patient; and

Softspan™ non‑breast tissue expanders, which are temporary devices intended to aid in the process of expanding tissue
and skin surface area for burn care and other reconstructive use.

Our Technology

Our current portfolio of breast implants utilizes what we believe are the most advanced technologies currently available
on  the  market.  These  technologies  are  supported  by  rigorous  product  testing,  analytics  and  clinical  data.  The  advanced
technologies in our products include:

High‑‑Strength  Cohesive  silicone  gel.   Our HSC and  HSC+ breast  implants  offer  a  desired  balance  between  strength,
shape  retention  and  softness  due  to  the  High‑Strength  Cohesive  silicone  gel  used  in  our  products.  The  use  of  High‑Strength
Cohesive silicone gel in our HSC and HSC+ breast implants in conjunction with our silicone shell allows the breast implants to
hold a controlled shape while maintaining a soft feel.

The  silicone  material  used  in  our  breast  implants  has  been  designed  to  provide  the  characteristics  desired  by  Plastic
Surgeons for breast implants. At present, we are the only company in the United States that has received FDA approval to use
High Strength Cohesive silicone gel in breast implants.

We  have  completed  a  number  of  studies  conducted  by  independent  laboratories  to  demonstrate  the  competitive
advantages  of  using  High‑Strength  Cohesive  silicone  gel  in  our  breast  implants.  We  believe  this  technology  differentiates  our
breast implants for the following reasons:

·

·

·

our implant gel is stronger, which is evidenced by its resistance to gel fracture;

due to the unique relationship between our implant gel and our implant shells, our implants have an enhanced ability to
retain their shape while preserving the shape of anatomically‑shaped implants without sacrificing the desired softness;
and

our shaped implants are softer and more elastic than our competitors’ shaped implants.

We believe the beneficial properties of our implants arise from the characteristics of the gel, as well as the integration of
the gel with our implant shell. Inside each of our implants, the gel adheres to the shell, creating additional structural strength and
shape retention in the implant. This results in the ability to deliver strength and shaping capability without a stiffer gel or implant
and without sacrificing the desired softness. We typically evaluate these characteristics using the following metrics:

·

Peel‑force.  Peel‑force is measured by the amount of force, measured in pound‑force, or lbf, necessary to separate the
outer  shell  of  the  implant  from  the  internal  gel  filling.  A  greater  peel‑force  measurement  indicates  greater  gel‑shell
integration. In the case of anatomically‑shaped implants, greater peel‑force can also be an indication of the ability of the
implant to retain its shape, particularly the upper portions of the implant, also referred to as the upper pole. Upper pole
stability is of particular importance in preserving the desired anatomical shape of an implant over time.

· Gel strength.  Gel strength is measured by the amount of force, measured in lbf, required to cause permanent fractures in

the gel. A larger value indicates greater strength.

· Gel  elasticity  and  implant  elasticity.    Gel  elasticity  and  implant  elasticity  can  be  measured  by  the  level  of  resistance,
measured  in  millimeters,  or  mm,  to  an  applied  constant  force.  A  higher  value  represents  greater  softness  and  a  lower
deformation value represents greater firmness.

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Sientra’s Implant Texture.  We sell breast implants that are available with a smooth outer surface or a textured outer
surface. We believe our textured breast implants offer us clinical advantages over our competitors’ textured products, including:  

·

·

better tissue adherence to reduce the incidence of malposition and rotation; and

reduction  in  the  rate  of  capsular  contracture,  a  complication  in  which  the  patient’s  body  creates  a  scar‑tissue  capsule
around the implant that can tighten and squeeze the implant potentially causing discomfort, pain and even dislocation of
the  implant.  While  we  have  neither  sought  nor  obtained  FDA  approval  to  state  that  our  breast  implants  reduces  the
incidence  of  capsular  contracture,  we  believe  it  may  significantly  reduce  this  risk,  as  evidenced  by  the  lower  rates  of
capsular contraction reported over a nine‑year follow‑up period in our ongoing clinical trial.

On a breast implant, the desired texture should have a proportionate amount of surface disruption, as overly aggressive
texture  can  result  in  double‑capsule  formation  while  not  enough  texturing  can  result  in  a  lack  of  adherence  resulting  in
malposition  or  rotation.  We  believe  that  our  textured  implants  have  the  right  combination  of  surface  disruption  without  overly
aggressive texturing.

By incorporating High‑Strength Cohesive silicone gel and our texturing into our breast implants, we believe we have a

competitive advantage in marketing and differentiating our products to Plastic Surgeons.

Our Clinical Data

In 2012, our breast implants were approved by the FDA based on data we collected from our ongoing, long‑term clinical
trial of our breast implants in 1,788 women across 36 investigational sites in the United States, which included 3,506 implants
(approximately 53% of which were smooth and 47% of which were textured). Our clinical trial results demonstrate the safety and
effectiveness  of  our  breast  implants  and  provide  Plastic  Surgeons  and  their  patients  the  security  and  confidence  to  choose  our
products.

Our  clinical  trial  is  the  largest  prospective,  long‑term  safety  and  effectiveness  pivotal  study  of  breast  implants  in  the
United States and included the largest magnetic resonance imaging, or MRI, cohort with 571 patients. The MRI cohort is a subset
of study patients that underwent regular MRI screenings in addition to the other aspects of the clinical trial protocol prior to FDA
approval.  Post-approval,  all  patients  in  the  long-term  clinical  trial  are  subject  to  serial  MRI  screening  as  part  of  the  clinical
protocol. The clinical data we collected over a nine‑year follow‑up period demonstrated rupture rates, capsular contracture rates
and reoperation rates that were comparable to or better than those of our competitors, at similar time points. In addition to our
pivotal study, our clinical data is supported by our Continued Access Study of 2,497 women in the United States. We have also
commissioned a number of bench trials run by independent laboratories that we believe further demonstrate the advantages of our
breast implants over those of our competitors.

We and our two competitors were required to run independent ten‑year clinical studies to obtain PMA approval from the
FDA.  Our  clinical  study  was  not  designed  to  facilitate  head‑to‑head  comparisons.    However,  our  clinical  data  and  our
competitors’  clinical  data  are  publicly  available  to  both  surgeons  and  patients  who  are  able  to  use  such  data  to  compare  and
contrast competing implants.

Our Services

Our services are designed to cater to the specific needs of Plastic Surgeons to enable them to maintain and grow their
practices. We provide our Plastic Surgeons with superior warranty programs, enhanced customer service offerings and specialized
educational initiatives. We believe that tailoring our customer service offerings to Plastic Surgeons helps secure their loyalty and
confidence.

Industry‑‑Leading  Product  Programs  and  Warranties.   Through  our  C3  Program,  we  provide  no ‑charge  replacement
implants  to  patients  who  experience  capsular  contracture  in  the  first  five  years  following  primary  breast  augmentation.  We
provide this benefit to every patient implanted with our smooth or textured breast implants. We also provide a ten‑year limited
warranty that we believe is the best in the industry, based on providing patients with the largest cash reimbursement for certain
out‑of‑pocket  costs  related  to  revision  surgeries  in  a  covered  event  and  a  lifetime  no‑charge  implant  replacement  program  for
covered ruptures.

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Enhanced Customer Service.  As we focus primarily on Plastic Surgeons and their patients, we believe we are able to

tailor our customer service offerings to their specific needs. Our surgeon‑facing customer service policies include:

·

·

·

·

·

·

simplified account setup through our sales representatives with pre‑qualification and pre‑approved credit terms;

no‑charge shipping to and from accounts;

six‑month pre‑approved returns of unused products with no‑charge return shipping and no restocking fees;

end‑of‑month statement billing, rather than one invoice per shipment, and 30‑day payment terms;

individualized consignment inventory; and

order acceptance by phone, fax, email or through our sales representatives.

Educational and Marketing Initiatives.   We have implemented  educational  and marketing  initiatives  with a focus  on

both Plastic Surgeons and their patients considering breast augmentation or reconstruction.

Plastic  Surgeons.    In  order  to  educate  Plastic  Surgeons  about  our  product  lines  and,  in  particular,  about  the
proper use of our anatomically‑shaped breast implants, we provide a variety of education programs for Plastic Surgeons
under the banner of the Sientra Education Forum. To date:

· we have developed a tablet‑based mobile marketing tool for our sales representatives to use while calling on accounts
that includes access to our patient  and surgeon labeling,  published clinical  studies, marketing  literature,  details  on our
warranty and C3 programs, our educational iBooks and more.

· we  host  symposia  with  one  or  more  key‑note  speakers  who  speak  on  topics  ranging  from  our  corporate  identity  and

customer service offerings to surgical tips and suggestions from thought‑leading Plastic Surgeons.

· we produce comprehensive guides for Plastic Surgeons via the Internet, referred to as iBooks, to provide them training

and expertise on the implantation of anatomically‑shaped breast implants.

· we send a limited number of Plastic Surgeons to Europe to observe surgeries and train with world‑renowned surgeons
who have  been  implanting  anatomically‑shaped  breast  implants  for  decades  and,  upon return  to  the  United  States,  we
engage them as consultant‑educators to conduct training sessions for other U.S.‑based Plastic Surgeons.

· we periodically sponsor educational surgical preceptorships where a small group of Plastic Surgeons are able to observe

a live surgery conducted by one of our trained preceptors and train with that preceptor.

Patients.    We  have  been  engaging  directly  with  consumers  who  are  considering  breast  augmentation  or
reconstruction.  We  initially  focused  our  consumer  educational  and  marketing  activities  on  websites  where  consumers
come to research their breast augmentation or reconstruction options, including:

·

·

our  own  consumer  website,  branded  with  our  “Feel  So  Good”  campaign,  that  provides  resources  for  consumers
considering  breast  augmentation  or  reconstruction,  including  referrals  and  commentaries,  product  descriptions,  patient
planning guides and educational brochures and information regarding our rupture warranty and C3 programs; and

our  exclusive  collaboration  with  RealSelf,  the  leading  online  community  helping  people  make  confident  choices  in
elective  cosmetic  procedures.  Together  with  RealSelf,  we  deliver  fresh  and  meaningful  content  to  the  RealSelf
community that answers common questions patients have regarding breast augmentation. This content is featured on a
dedicated Sientra page on RealSelf’s website designed to build consumer engagement with the brand and open up the
online conversation around breast augmentation directly with Plastic Surgeons.

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We  believe  that  our  innovative  services,  including  industry‑leading  product  programs  and  warranties,  enhanced
customer  service  offerings  and  educational  and  marketing  initiatives,  deliver  an  improved  customer  experience  to  Plastic
Surgeons and their patients.

Sales and Marketing

As of December 31, 2016, we had a sales organization of 43 employees, including 36 sales representatives and 7 sales
managers.    We  assign  sales  territories  based  on  the  regions  with  the  highest  concentration  of  accounts.  Our  sales  team  is
supported by customer and sales experience teams, which provide full‑time telephonic and email customer support to our sales
representatives and customers.

In  addition,  our  marketing  team  leads  our  efforts  in  brand  development,  trade  show  attendance,  educational  forums,

product messaging, website development and advertising, among others.

Research and Development

We  have  incurred,  and  expect  to  continue  to  incur,  significant  research  and  development  expenses.  Our  research  and
development expenses were approximately $9.7 million, $7.2 million and $4.7 million for the years ended December 31, 2016,
 2015  and  2014,  respectively.  Our  research  and  development  is  focused  on  enhancing  and  improving  our  Breast  Products,
increasing our breast implant portfolio, product development related activities and expanding into synergistic markets. We believe
research  and  development  is  important  to  the  success  of  the  Company  as  we  continue  to  develop  and  expand  our  product
portfolio.

Manufacturing and Quality Assurance

We hold an FDA Medical Device Establishment Registration.  All of our medical device products are listed under our
Device Listing where it indicates we are the specification developer of our products, and except for our breast implant sizers, we
are  the  owner  of  our  products’  FDA  approvals  and  clearances.  This  means  that  we  are  primarily  responsible  for  the  design,
manufacturing and quality assurance of our products. However, we do not manufacture our products ourselves. Instead, we rely
on our third-party manufacturers to manufacture and package our silicone gel breast implants, tissue expanders and other products
to our specifications. When we receive our products from our third-party manufacturers, we inspect a representative sample of
packaging and labeling prior to shipping them to our customers. We typically maintain strategic levels of inventory at our storage
facilities located in Santa Barbara, California. As a result of the events with Silimed, currently all of the remaining inventory we
received from Silimed is located at this storage facility.

We, along with our third-party manufacturers are subject to the FDA’s Quality System Regulation, or QSR, reporting
requirements and current Good Manufacturing Practices, or cGMP, audits by the FDA. Under the QSR and cGMP requirements,
manufacturers,  including  third-party  manufacturers,  must  follow  stringent  design,  testing,  production,  control,  supplier  and
contractor  selection,  complaint  handling,  documentation  and  other  quality  assurance  procedures  during  all  aspects  of  the
manufacturing  process.  The  FDA  has  regularly  inspected  both  the  Company  and  Silimed.      The  FDA  has  never  found  the
Company or Silimed to be in violation of any part of the Federal Food, Drug and Cosmetic Act, or FDCA.

Historically, all of our silicone gel breast implants were manufactured by Silimed pursuant to an amended and restated
exclusivity  agreement  with  Silimed,  which  we  refer  to  as  the  Silimed  Agreement.  Several  events  have  occurred  which  have
affected  our  supply  of  silicone  gel  breast  implants.  These  events  includ  e  the  suspension  of  Silimed’s  CE  and  ISO  13485
certificate  by  TÜV  SÜD  followed  by  a  suspension  by  the  Brazilian  regulatory  agency  ANVISA  and  the  Department  of  the
Secretary  of  State  of  Rio  de  Janeiro  of  the  manufacturing  and  shipment  of  all  medical  devices  made  by  Silimed,  including
products manufactured for Sientra, and the Silimed manufacturing facility where Sientra breast implants were manufactured was
damaged  by  a  fire  on  October  22,  2015.      As  a  result  of  the  suspensions,  between  October  9,  2015  and  March  1,  2016,  we
voluntarily  placed  a  temporary  hold  on  the  sale  of  all  Sientra  devices  manufactured  by  Silimed  and  recommended  that  plastic
surgeons discontinue implanting the devices until further notice. On March 1, 2016, after ongoing discussions with the FDA and
our own review of the matter with the assistance of independent experts in quality management systems, GMP and data-based
risk assessment, we lifted this temporary hold on sale and informed our Plastic Surgeons of our controlled market re-entry plan
designed to optimize our inventory supply, which continues to be limited.  The events involving Silimed will likely continue to
adversely  impact  our  business,  in  particular  due  to  the  limitations  on  our  existing  inventory  levels,  the  uncertainty  of  our
customers’ responsiveness to our controlled market re-entry plan, the fact that Silimed filed a lawsuit against us alleging, among
other things, a material breach of the existing manufacturing

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contract , and the fact that the manufacturing contract with Silimed expires on its terms on April 1, 2017.  See “Risk Factors —
Risks Relating to Our Business and Our Industry” for further detail. 

Pursuant to the Silimed Agreement, in the event Silimed fails to supply products ordered by us, we may, under certain
circumstances, exercise manufacturing rights to manufacture the products directly or through a third-party manufacturer. Silimed
also granted  to  us  an  exclusive,  royalty‑free,  non‑transferable  license  to  use  certain  of  its  trademarks  in  the  United  States  and
Canada, which we refer to as the Territory, including in the event Silimed fails to supply the products to us and in connection with
the marketing and sale of the products in the Territory. In addition, the Silimed Agreement addresses intellectual property rights,
including that the parties will jointly own all developments, modifications, enhancements or alterations of products jointly created
by  the  parties,  subject  to  certain  restrictions  concerning  the  use  of  such  improvements  outside  of  the  Territory.  Each  party  is
subject to certain limitations and other restrictions on the transfer of the other party’s technology to third parties.

In  response  to  these  events  and  anticipated  impacts  on  our  business,  we  have  increasingly  focused  our  efforts  on
securing  and  qualifying  an  alternate  manufacturing  supplier.    On  August  9,  2016,  we  announced  our  collaboration  with  Vesta,
pursuant  to  which  we  are  working  with  Vesta  towards  establishing  a  dedicated  contract  manufacturing  facility  for  our  breast
implants.  On  March  14,  2017,  we  announced  that  we  had  executed  a  definitive  manufacturing  agreement  with  Vesta  for  the
manufacture and supply of our breast implants.  In addition, on March 14, 2017, we announced that we had submitted a PMA
supplement to the FDA for the manufacturing of our PMA-approved breast implants by Vesta.

Competition

The medical device industry is intensely competitive, subject to rapid change and highly sensitive to the introduction of
new products or other market activities of industry participants. We primarily compete with two companies that manufacture and
sell breast implants in the United States: Johnson & Johnson through its wholly owned subsidiary, Mentor Worldwide, LLC, or
Mentor, and Allergan plc, or Allergan.

Both  of  our  U.S.  competitors  are  either  publicly‑traded  companies  or  divisions  or  subsidiaries  of  publicly‑traded
companies with significantly more market share and resources than we have. These companies have greater financial resources
for sales, marketing and product development, broader established relationships with healthcare providers and third‑party payors,
and larger and more established distribution networks. In some instances, our competitors also offer products that include features
that  we  do  not  currently  offer.  For  example,  Allergan  sells  temporary  gel  sizers  for  silicone  gel  implants  and  we  sell  only
temporary  saline  filled  sizers.  In  addition,  our  competitors  may  offer  pricing  programs  with  discounts  across  their  non‑breast
aesthetic product portfolios.

We also face potential future competition from a number of companies, medical researchers and existing medical device
companies  that  may  be  pursuing  new  implant  technologies,  new  material  technologies  and  new  methods  of  enhancing  and
reconstructing the breast.

We believe the primary competitive factors in our markets include:

·

·

·

·

·

·

breadth of portfolio;

technological characteristics of products;

clinical evidence;

product price;

customer service; and

support by key opinion leaders.

Government Regulation

Our products are subject to extensive regulation by the FDA and other federal and state regulatory authorities, Health
Canada  and,  if  we  commence  international  sales  outside  of  the  United  States  and  Canada,  other  regulatory  bodies  in  other
countries.

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Regulation  by  the  FDA.   The  Federal  Food,  Drug  and  Cosmetic  Act,  or  FDCA,  and  the  FDA’s  implementing

regulations govern, among other things:

·

·

·

·

·

·

·

·

·

·

·

·

·

product design and development;

pre‑clinical and clinical testing;

establishment registration and product listing;

product manufacturing;

product labeling and storage;

pre‑market clearance or approval;

post‑market studies;

advertising and promotion;

product sales and distribution;

record-keeping and device tracking;

complaint handling;

recalls and field safety corrective actions; and

post‑market
device malfunctions.

 surveillance  and  adverse  event

 reporting,

 including  reporting  of  deaths,

 serious  injuries  or

Unless an exemption applies, each new or significantly modified medical device we seek to commercially distribute in
the United States will require either a pre‑market notification to the FDA requesting permission for commercial distribution under
Section 510(k) of the FDCA, also referred to as a 510(k) clearance, or approval from the FDA of a PMA application. Both the
510(k) clearance and PMA approval processes can be expensive, lengthy and require payment of significant user fees, unless an
exemption is available.

The FDA classifies medical devices into one of three classes. Unless specifically exempted from certain requirements,
all three classes of devices are subject to general controls such as labeling, pre‑market notification and adherence to the FDA’s
QSR,  which  cover  manufacturers’  methods  and  documentation  of  the  design,  testing,  production,  control,  quality  assurance,
labeling, packaging, sterilization, storage and shipping of products. Devices deemed to pose low to moderate risk are placed in
Class  I  or  II,  which,  absent  an  exemption,  requires  the  applicant  to  obtain  a  510(k)  clearance.  Class  II  devices  are  subject  to
special  controls  such  as  performance  standards,  post‑market  surveillance,  FDA  guidelines,  or  particularized  labeling
requirements,  as  well  as  general  controls.  Some  low  risk  devices  are  exempted  by  regulation  from  the  510(k)  clearance
requirement, and/or the requirement of compliance with substantially all of the QSR. A PMA application is required for devices
deemed by the FDA to pose the greatest risk, such as life‑sustaining, life‑supporting or certain implantable devices, including all
breast implants, or devices that are “not substantially equivalent” either to a device previously cleared through the 510(k) process
or  to  a  “preamendment”  Class  III  device  in  commercial  distribution  in  the  United  states  before  May  28,  1976  for  which  a
regulation requiring a PMA application has not been issued by the FDA.

Our tissue expanders and our body contouring, facial and nasal implants received FDA clearance as Class II devices at
various dates prior to approval of our breast implants in March 2012. To obtain 510(k) clearance, we must submit a pre‑market
notification  demonstrating  that  the  proposed  device  is  substantially  equivalent  to  a  previously  cleared  510(k)  device  or  a
preamendment device. The FDA’s 510(k) clearance pathway usually takes from three to 12 months from the date the application
is completed, but it can take significantly longer and clearance is never assured. Although many 510(k) pre‑market notifications
are cleared without clinical data, in some cases, the FDA requires significant clinical

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data  to  support  substantial  equivalence.  In  reviewing  a  pre‑market  notification,  the  FDA  may  request  additional  information,
including  clinical  data,  which  may  significantly  prolong  the  review  process.  After  a  device  receives  510(k)  clearance,  any
modification  that  could  significantly  affect  its  safety  or  effectiveness,  or  that  would  constitute  a  new  or  major  change  in  its
intended use, will require a new 510(k) clearance or, depending on the modification, could require a PMA application. The FDA
requires each manufacturer to make this determination initially, but the FDA can review any such decision and can disagree with
a manufacturer’s determination. If the FDA disagrees with a manufacturer’s determination regarding whether a new pre‑market
submission is required for the modification of an existing device, the FDA can require the manufacturer to cease marketing and/or
recall the modified device until 510(k) clearance or approval of a PMA application is obtained. If the FDA requires us to seek
510(k) clearance or approval of a PMA application for any modifications to a previously cleared product, we may be required to
cease marketing or recall the modified device until we obtain this clearance or approval. In addition, in these circumstances, we
may  be  subject  to  significant  regulatory  fines  or  penalties  for  failure  to  submit  the  requisite  510(k)  clearance(s)  or  PMA
application(s).  In  addition,  the  FDA  is  currently  evaluating  the  510(k)  process  and  may  make  substantial  changes  to  industry
requirements.

Silicone gel breast implants are treated as Class III devices and a full PMA is required. A PMA for our breast implants
was approved by the FDA in March 2012. The PMA application process is generally more costly and time consuming than the
510(k) process and requires proof of the safety and effectiveness  of the device to the FDA’s satisfaction.  Accordingly, a PMA
application  must  be  supported  by  valid  scientific  evidence  that  typically  includes,  but  is  not  limited  to,  extensive  information
regarding the product, including pre‑clinical, clinical, and other product data to demonstrate to the FDA’s satisfaction the safety
and effectiveness of the device for its intended use. After a PMA application is submitted and found to be sufficiently complete,
the  FDA  begins  an  in‑depth  review  of  the  submitted  information.  By  statute,  the  FDA  has  180  days  to  review  the  “accepted
application,” although, generally, review of the application takes between one and three years, but may take significantly longer.
During  this  review  period,  the  FDA  may  request  additional  information  or  clarification  of  information  already  provided.  Also
during  the  review  period,  an  advisory  panel  of  experts  from  outside  the  FDA  may  be  convened  to  review  and  evaluate  the
application and provide recommendations to the FDA as to the approvability of the device. In addition, the FDA generally will
conduct  a  pre‑approval  inspection  of  the  intended  manufacturing  facility  to  evaluate  compliance  with  QSR,  which  requires
manufacturers to implement and follow elaborate design, testing, control, documentation and other quality assurance procedures
in the device design and manufacturing process.

The FDA may approve a PMA application with post‑approval conditions intended to ensure the safety and effectiveness
of the device including, among other things, restrictions on labeling, promotion, sale and distribution and collection of long‑term
follow‑up data from patients in the clinical study that supported approval. Failure to comply with the conditions of approval can
result in materially adverse enforcement action, including the loss or withdrawal of the approval. New PMA applications or PMA
supplements are required for significant modifications to the manufacturing process, labeling and design of a device that could
affect the safety or effectiveness of the device, including, for example, certain types of modifications to the device’s indication for
use, manufacturing process, labeling and design. PMA supplements often require submission of the same type of information as a
PMA application, except that the supplement is limited to information needed to support any changes from the device covered by
the original PMA application, and may not require as extensive clinical data or the convening of an advisory panel, depending on
the nature of the proposed change.

Clinical  Trials.   A  clinical  trial  is  almost  always  required  to  support  a  PMA  application  and  may  be  required  for  a
510(k) pre‑market notification. In the United States, absent certain limited exceptions, human clinical trials intended to support
product clearance or approval require an Investigational Device Exemption, or IDE, application. Some types of studies deemed to
present  “non‑significant  risk”  are  deemed  to  have  an  approved  IDE  once  certain  requirements  are  addressed  and  institutional
review board, or IRB, approval is obtained. If the device presents a “significant risk” to human health, as defined by the FDA, the
Sponsor must submit an IDE application to the FDA and obtain IDE approval prior to commencing the human clinical trials. The
IDE application must be supported by appropriate data, such as animal and laboratory testing results, showing that it is safe to
evaluate  the  device  in  humans  and  that  the  testing  protocol  is  scientifically  sound.  The  IDE  application  must  be  approved  in
advance by the FDA for a specified number of subjects, unless the product is deemed a non‑significant risk device and eligible for
more abbreviated IDE requirements. Clinical trials for a significant risk device may begin once the IDE application is approved
by the FDA and the responsible institutional review boards at the clinical trial sites. There can be no assurance that submission of
an IDE will result in the ability to commence clinical trials. Additionally, after a trial begins, the FDA may place it on hold or
terminate it if, among other reasons, it concludes that the clinical subjects are exposed to unacceptable health risks that outweigh
the  benefits  of  participation  in  the  study.  During  a  study,  we  are  required  to  comply  with  the  FDA’s  IDE  requirements  for
investigator

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selection,  clinical  trial  monitoring,  reporting,  record  keeping  and  prohibitions  on  the  promotion  of  investigational  devices  or
making safety or efficacy claims for them. We are also responsible for the appropriate labeling and distribution of investigational
devices. Our clinical trials must be conducted in accordance with FDA regulations and federal and state regulations concerning
human subject protection, including informed consent and healthcare privacy. The investigators must also obtain patient informed
consent,  rigorously  follow  the  investigational  plan  and  study  protocol,  control  the  disposition  of  investigational  devices  and
comply with all reporting and record-keeping requirements. The FDA’s grant of permission to proceed with clinical testing does
not constitute a binding commitment that the FDA will consider the study design adequate to support clearance or approval. In
addition,  there  can  be  no  assurance  that  the  data  generated  during  a  clinical  study  will  meet  chosen  safety  and  effectiveness
endpoints or otherwise produce results that will lead the FDA to grant marketing clearance or approval.

Other Regulatory Requirements.  Even though our breast implants have been approved and commercialized, numerous
regulatory requirements apply after a device is placed on the market, regardless of its classification or pre‑market pathway. These
include, but are not limited to:

·

establishment registration and device listing with the FDA;

· QSR, which requires manufacturers, including third-party manufacturers, to follow stringent design, testing, production,
control,  supplier  and  contractor  selection,  complaint  handling,  documentation  and  other  quality  assurance  procedures
during all aspects of the manufacturing process;

·

labeling  regulations  that  prohibit  the  promotion  of  products  for  uncleared  or  unapproved,  or  “off‑label,”  uses,  and
impose other restrictions on labeling, advertising and promotion;

· medical Device Reporting, or MDR, regulations, which require that manufacturers report to the FDA if their device may
have caused or contributed to a death or serious injury or malfunctioned in a way that would likely cause or contribute to
a death or serious injury if the malfunction were to recur; and

·

corrections and removals reporting regulations, which require that manufacturers report to the FDA field corrections and
product recalls or removals if undertaken to reduce a risk to health posed by the device or to remedy a violation of the
FDCA  that  may  present  a  risk  to  health.  In  addition,  the  FDA  may  order  a  mandatory  recall  if  there  is  a  reasonable
probability that the device would cause serious adverse health consequences or death.

The  FDA  requires  us  to  conduct  post‑market  surveillance  studies  and  to  maintain  a  system  for  tracking  our  breast
implants through the chain of distribution to the patient level. The FDA enforces regulatory requirements by conducting periodic,
unannounced inspections and market surveillance. Inspections may include the manufacturing facilities of our subcontractors.

Failure by us or our manufacturer to comply with applicable regulatory requirements can result in enforcement actions
by  the  FDA  and  other  regulatory  agencies.  These  may  include,  but  may  not  be  limited  to,  any  of  the  following  sanctions  or
consequences:

· warning letters or untitled letters that require corrective action;

·

·

·

·

·

·

fines and civil penalties;

unanticipated expenditures;

delays in or refusal to grant requests for 510(k) clearance or pre‑market approval of new products or modified products;

FDA refusal to issue certificates to foreign governments needed to export products for sale in other countries;

suspension or withdrawal of FDA clearance or approval;

product recall, detention or seizure;

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·

·

·

operating restrictions, partial suspension or total shutdown of production;

injunctions and consent decrees; and

criminal prosecution.

We  and  our  contract  manufacturers  and  some  suppliers  of  components  or  device  accessories  also  are  required  to
manufacture our products in compliance with cGMP requirements set forth in the QSR. The QSR requires a quality system for the
design,  manufacture,  packaging,  labeling,  storage,  installation  and  servicing  of  marketed  devices,  and  it  includes  extensive
requirements with respect to quality management and organization, device design, buildings, equipment, purchase and handling
of  components  or  services,  production  and  process  controls,  packaging  and  labeling  controls,  device  evaluation,  distribution,
installation, complaint handling, servicing, and record keeping. The FDA evaluates compliance with the QSR through periodic,
unannounced inspections that may include the manufacturing facilities of our subcontractors. If the FDA believes that we or any
of  our  contract  manufacturers  or  regulated  suppliers  are  not  in  compliance  with  these  requirements,  it  can  shut  down  our
manufacturing operations, require recall of our products, refuse to approve new marketing applications, institute legal proceedings
to  detain  or  seize  products,  enjoin  future  violations  or  assess  civil  and  criminal  penalties  against  us  or  our  officers  or  other
employees.

Healthcare  Regulatory  Laws.   Our  business  activities,  including  but  not  limited  to,  research,  sales,  marketing,
promotion,  distribution,  medical  education  and  other  activities  are  subject  to  regulation  under  additional  healthcare  laws  by
numerous  regulatory  and  enforcement  authorities  in  the  United  States,  in  addition  to  the  FDA.  These  laws  include,  without
limitation,  state  and  federal  anti‑kickback,  false  claims,  physician  sunshine,  and  patient  data  privacy  and  security  laws  and
regulations, including but not limited to those described below.

Additionally, our relationships with healthcare providers and other third parties are subject to scrutiny under these laws.
Non‑compliance  with  the  laws  described  below  may  generally  result  in  the  imposition  of  civil,  criminal  and  administrative
penalties,  damages, monetary  fines, disgorgement,  individual  imprisonment,  possible exclusion from participation  in Medicare,
Medicaid and other federal healthcare programs, contractual damages, reputational harm, diminished profits and future earnings,
additional reporting requirements and oversight if we become subject to a corporate integrity agreement or similar agreement to
resolve allegations of non-compliance with these laws, and curtailment of our operations, any of which could adversely affect our
ability to operate our business and our results of operations. Defending against any actions for non‑compliance of such laws can
be costly, time‑consuming and may require significant financial and personnel resources. Therefore, even if we are successful in
defending against any such actions that may be brought against us, our business may be impaired.

Federal Anti‑‑Kickback Law.  The federal Anti‑Kickback Statute prohibits, among other things, knowingly or willfully
soliciting, receiving, offering, or paying remuneration, directly or indirectly, to induce, or in return for, either the referral of an
individual  or  the  purchase,  recommendation,  order  or  furnishing  of  an  item  or  service  reimbursable  under  a  federal  healthcare
program, such as the Medicare and Medicaid programs. The definition of “remuneration” has been broadly interpreted to include
anything  of  value,  including  such items  as  improper  payments,  gifts,  discounts,  the furnishing  of  supplies  or  equipment,  credit
arrangements,  waiver  of  payments  and  providing  anything  at  other  than  its  fair  market  value.  There  are  a  number  of  statutory
exceptions  and  regulatory  safe  harbors  protecting  certain  common  activities  from  prosecution.  Failure  to  meet  all  of  the
requirements  of  a  particular  applicable  statutory  exception  or  regulatory  safe  harbor  does  not  make  the  conduct  per  se  illegal
under the federal Anti‑Kickback Statute. Instead, the legality of the arrangement will be evaluated on a case‑by‑case basis based
on a cumulative review of all of its facts and circumstances.

The penalties for violating the federal Anti‑Kickback Statute include imprisonment for up to five years, fines of up to
$25,000 per violation and possible exclusion from federal healthcare programs such as Medicare and Medicaid. Further, a person
or  entity  does  not  need  to  have  actual  knowledge  of  this  statute  or  specific  intent  to  violate  it  in  order  to  commit  a  violation.
Rather, if “one purpose” of the remuneration is to induce referrals, the federal Anti-Kickback Statute is violated. In addition, a
claim including items or services resulting from a violation of the federal Anti‑Kickback Statute constitutes a false or fraudulent
claim for purposes of the federal civil False Claims Act, or FCA.

We  have  entered  into  consulting,  speaker  and  other  financial  arrangements  with  physicians,  including  some  who
prescribe  or  recommend  our  products  to  patients.  We  engage  such  physicians  as  consultants,  advisors  and  to  educate  other
physicians. Noncompliance with the federal Anti‑Kickback Statute could result in the penalties set forth above.

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Federal Civil False Claims Act.  The FCA prohibits any person from knowingly presenting, or causing to be presented,
a false claim for payment to the federal government, or knowingly making, using or causing to be made or used, a false record or
statement  material  to  a  false  or  fraudulent  claim  to  the  federal  government.  The  FCA  has  been  used  to  prosecute  persons
submitting claims for payment that are inaccurate or fraudulent, that are for services not provided as claimed, or for services that
are not medically  necessary.  Manufacturers  can be held liable  under the FCA if they are deemed to “cause”  the submission of
false  or  fraudulent  claims  by,  for  example,  providing  inaccurate  billing  or  coding  information  to  customers  or  promoting  a
product  off‑label.  Penalties  for  FCA  violations  include  three  times  the  actual  damages  sustained  by  the  government,  plus
mandatory civil penalties of between $10,781.40 and $21,562.80 for each separate false claim, the potential for exclusion from
participation in federal healthcare programs, and, although the federal FCA is a civil statute, FCA violations may also implicate
various federal criminal statutes.

In  addition  to  actions  initiated  by  the  government  itself,  the  statute  authorizes  actions  to  be  brought  on  behalf  of  the
federal government by a private  party having knowledge of the alleged fraud, known as “qui tam”, or whistleblower, lawsuits.
Because the complaint is initially filed under seal, the action may be pending for some time before the defendant is even aware of
the action. If the government intervenes and is ultimately successful in obtaining redress in the matter, or if the plaintiff succeeds
in obtaining redress without the government’s involvement, then the plaintiff will receive a percentage of the recovery. Qui tam
actions have increased significantly in recent years, causing greater numbers of healthcare companies to have to defend a false
claim action, pay fines or be excluded from Medicare, Medicaid or other federal or state healthcare  programs as a result of an
investigation arising out of such action.

Federal Criminal False Claims Laws.  The federal criminal false claims laws prohibit, among other things, knowingly
and willfully making, or causing to be made, a false statement or representation of a material fact for use in determining the right
to any benefit or payment under a federal health care program. A violation of these laws may constitute a felony or misdemeanor
and may result in fines or imprisonment.

Civil Monetary Penalties Law.  The federal Civil Monetary Penalties Law prohibits, among other things, the offering or
transferring of remuneration to a Medicare or Medicaid beneficiary that the person knows or should know is likely to influence
the beneficiary’s selection of a particular supplier of Medicare or Medicaid payable items or services. Noncompliance with such
beneficiary inducement provision of the federal Civil Monetary Penalties Law can result in civil money penalties of up to $10,000
for  each  wrongful  act,  assessment  of  three  times  the  amount  claimed  for  each  item  or  service  and  exclusion  from  the  federal
healthcare programs.

Health Insurance Portability and Accountability Act of 1996.  The Health Insurance Portability and Accountability Act
of  1996,  or  HIPAA,  augmented  two  federal  crimes:  healthcare  fraud  and  false  statements  relating  to  healthcare  matters.  The
healthcare fraud statute prohibits knowingly and willfully executing, or attempting to execute, a scheme to defraud any healthcare
benefit  program,  including  private  payors.  A  violation  of  this  statute  is  a  felony  and  may  result  in  fines,  imprisonment  or
exclusion from governmental programs. The false statements statute prohibits knowingly and willfully falsifying, concealing or
covering up a material fact or making any materially false, fictitious or fraudulent statement in connection with the delivery of or
payment for healthcare benefits, items or services. A violation of this statute is a felony and may result in fines or imprisonment.

HIPAA,  as  amended  by  the  Health  Information  Technology  for  Economic  and  Clinical  Health  Act,  or  HITECH,  and
their implementing regulations, including the Final HIPAA Omnibus Rule published on January 25, 2013, mandates, among other
things,  that  certain  types  of  entities  and  individuals  adopts  uniform  standards  for  the  electronic  exchange  of  information  in
common  healthcare  transactions,  as  well  as  standards  relating  to  the  privacy  and  security  of  individually  identifiable  health
information, which require the adoption of administrative, physical and technical safeguards to protect such information. Among
other  things,  HITECH  makes  certain  of  HIPAA’s  standards  and  requirements  directly  applicable  to  “business  associates”—
independent contractors or agents of covered entities that create, receive or obtain protected health information in connection with
providing  a  service  for  or  on  behalf  of  a  covered  entity.  HITECH  also  increased  the  civil  and  criminal  penalties  that  may  be
imposed against covered entities and business associates, and gave state attorneys general new authority to file civil actions for
damages or injunctions in federal courts to enforce the federal HIPAA laws and seek attorney’s fees and costs associated with
pursuing  federal  civil  actions.  In  addition,  certain  state  laws  govern  the  privacy  and  security  of  health  information  in  certain
circumstances, some of which are more stringent than HIPAA and many of which differ from each other in significant ways and
may  not  have  the  same  effect,  thus  complicating  compliance  efforts.  Failure  to  comply  with  these  laws,  where  applicable,  can
result in the imposition of significant civil and/or criminal penalties.

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Physician Payments Sunshine Act.  The Patient Protection and Affordable Care Act, as amended by the Health Care
and  Education  Reconciliation  Act  of  2010,  or  collectively,  PPACA,  imposed,  among  other  things,  new  annual  reporting
requirements for certain manufacturers of drugs, devices, biologics, and medical supplies for which payment is available under
Medicare,  Medicaid,  or  the  Children’s  Health  Insurance  Program,  for  certain  payments  and  “transfers  of  value”  provided  to
physicians and teaching hospitals, as well as ownership and investment interests held by physicians and their immediate family
members. Failure to submit timely, accurately, and completely the required information for all payments, transfers of value and
ownership or investment interests may result in civil monetary penalties of up to an aggregate of $150,000 per year and up to an
aggregate of $1 million per year for “knowing failures,” for all payments, transfers of value or ownership or investment interests
that are not timely, accurately, and completely reported in an annual submission. We are required to report detailed payment data
and submit legal attestation to the accuracy of such data by March 31st of each calendar year.

In  addition,  there  has  been  a  recent  trend  of  increased  federal  and  state  regulation  of  payments  and  other  transfers  of
value  provided  to  healthcare  professionals  and  entities.  Similar  to  the  federal  law,  certain  states  also  have  adopted  marketing
and/or transparency laws relevant to device manufacturers, some of which are broader in scope. Certain states, such as California
and Connecticut, also mandate that device manufacturers implement compliance programs. Other states, such as Massachusetts
and  Vermont,  impose  restrictions  on  device  manufacturer  marketing  practices  and  require  tracking  and  reporting  of  gifts,
compensation,  and  other  remuneration  to  healthcare  professionals  and  entities.  The  need  to  build  and  maintain  a  robust
compliance program with different compliance and/or reporting requirements increases the possibility that a healthcare company
may violate one or more of the requirements, resulting in fines and penalties

Additional State Healthcare Laws.  Many states have also adopted some form of each of the aforementioned laws, some
of which may be broader in scope and may apply regardless of payor. Nevertheless, a determination of liability under such laws
could result in fines and penalties and restrictions on our ability to operate in these jurisdictions.

Additionally, as some of these laws are still evolving, we lack definitive guidance as to the application of certain key
aspects of these laws as they relate to our arrangements with providers with respect to patient training. We cannot predict the final
form that these regulations will take or the effect that the final regulations will have on us. As a result, our provider and training
arrangements may ultimately be found to be not in compliance with applicable laws.

United  States  Foreign  Corrupt  Practices  Act.   The  United  States  Foreign  Corrupt  Practices  Act,  or  FCPA,  prohibits
United States corporations and their representatives from offering, promising, authorizing or making corrupt payments, gifts or
transfers  to  any  foreign  government  official,  government  staff  member,  political  party  or  political  candidate  in  an  attempt  to
obtain or retain business abroad. The scope of the FCPA would include interactions with certain healthcare professionals in many
countries.

International Regulation.  We may evaluate international expansion opportunities in the future. International sales of
medical  devices  are  subject  to  local  government  regulations,  which  may  vary  substantially  from  country  to  country.  The  time
required to obtain approval in another country may be longer or shorter than that required for FDA approval, and the requirements
may differ. There is a trend towards harmonization of quality system standards among the European Union, United States, Canada
and various other industrialized countries.

The primary  regulatory  body in Europe is that of the European  Union, which includes  most of the major  countries  in
Europe.  Other  countries,  such  as Switzerland,  have  voluntarily  adopted  laws and  regulations  that  mirror  those of  the European
Union with respect to medical devices. The European Union has adopted numerous directives and standards regulating the design,
manufacture, clinical trials, labeling and adverse event reporting for medical devices. Devices that comply with the requirements
of  a  relevant  directive  will  be  entitled  to  bear  the  CE  conformity  marking,  indicating  that  the  device  conforms  to  the  essential
requirements  of the applicable  directives  and, accordingly,  can be commercially  distributed  throughout Europe. The method  of
assessing conformity varies depending on the class of the product, but normally involves a combination of self‑assessment by the
manufacturer  and  a  third  party  assessment  by  a  “Notified  Body.”  This  third‑party  assessment  may  consist  of  an  audit  of  the
manufacturer’s  quality  system  and  specific  testing  of  the  manufacturer’s  product.  An  assessment  by  a  Notified  Body  of  one
country within the European Union is required in order for a manufacturer to commercially distribute the product throughout the
European  Union.  Additional  local  requirements  may  apply  on  a  country‑by‑country  basis.  Outside  of  the  European  Union,
regulatory approval would need to be sought on a country‑by‑country basis in order for us to market our products.

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Coverage and Reimbursement.  Sales of our products depend, in part, on the extent to which the procedures using our
products  will  be  covered  by  third‑party  payors,  such  as  government  health  care  programs,  commercial  insurance  and  managed
healthcare  organizations.  Breast  augmentation  procedures  are  generally  performed  on  a  cash‑pay  basis  and  are  not  covered  by
third‑party  payors.  In  contrast,  breast  reconstruction  procedures  may  be  covered  by  third‑party  payors,  but  such  third‑party
payors are increasingly limiting coverage and reducing reimbursements for medical products and services. In addition, the U.S.
government, state legislatures and foreign governments have continued implementing cost‑containment programs, including price
controls,  restrictions  on  coverage  and  reimbursement.  Third-party  payors  are  increasingly  challenging  the  price,  examining  the
medical necessity and reviewing the cost-effectiveness of medical drug products and medical services, in addition to questioning
their safety and efficacy. Adoption of price controls and cost‑containment measures, and adoption of more restrictive policies in
jurisdictions with existing controls and measures, could further limit our net sales and results.

Moreover, the process for determining whether a third-party payor will provide coverage for a product or procedure may
be separate from the process for establishing the reimbursement rate that such a payor will pay for the product or procedure. A
payor’s  decision  to  provide  coverage  for  a  product  or  procedure  does  not  imply  that  an  adequate  reimbursement  rate  will  be
approved. Further, one payor’s determination  to provide coverage for a product or procedure does not assure that other payors
will also provide coverage for the product or procedure. Adequate third-party reimbursement may not be available to enable us to
maintain price levels sufficient to ensure profitability.

Health  Reform.    The  United  States  and  some  foreign  jurisdictions  are  considering  or  have  enacted  a  number  of
legislative and regulatory proposals to change the healthcare system in ways that could affect our business. Among policy makers
and payors in the United States and elsewhere, there is significant interest in promoting changes in healthcare systems with the
stated goals of containing healthcare costs, improving quality or expanding access.

By  way  of  example,  in  the  United  States,  the  PPACA  is  an  example  of  a  reform  measure  with  the  potential  to
substantially  change  healthcare  financing  and  delivery  by  both  governmental  and  private  insurers,  and  significantly  impact  the
pharmaceutical  and medical  device  industries.  The PPACA imposed,  among other  things, a new federal  excise  tax of 2.3% on
certain entities that manufacture or import medical devices for sale in the United States and implemented payment system reforms
including  a  national  pilot  program  on payment  bundling to  encourage  hospitals,  physicians  and other  providers  to  improve  the
coordination, quality and efficiency of certain healthcare services through bundled payment models. The medical device excise
tax has been suspended by the Consolidated Appropriations Act of 2016, or the CAA, with respect to medical device sales during
calendar years 2016 and 2017.  Absent further Congressional action, this excise tax will be reinstated for medical device sales
beginning  January  1,  2018.    The  CAA  also  temporarily  delays  implementation  of  other  taxes  intended  to  help  fund  PPACA
programs.

The full impact of the PPACA on our business remains unclear.  There have been judicial and Congressional challenges
to  certain  aspects  of the  PPACA, and we  expect  there  will  be additional  challenges  and  amendments  in the  future.  In  January,
Congress voted to adopt a budget resolution for fiscal year 2017, or the Budget Resolution, that authorizes the implementation of
legislation that would repeal portions of the PPACA.  The Budget Resolution is not a law; however, it is widely viewed as the
first  step  toward  the  passage  of  repeal  legislation.  Further,  on  January  20,  2017,  President  Trump  signed  an  Executive  Order
directing federal agencies with authorities and responsibilities under the PPACA to waive, defer, grant exemptions from, or delay
the  implementation  of  any  provision  of  the  PPACA  that  would  impose  a  fiscal  or  regulatory  burden  on  states,  individuals,
healthcare  providers,  health  insurers,  or  manufacturers  of  pharmaceuticals  or  medical  devices.  Congress  also  could  consider
subsequent legislation to replace elements of the PPACA that are repealed.

In  addition,  other  legislative  changes  have  been  proposed  and  adopted  since  the  PPACA  was  enacted.  On  August  2,
2011,  President  Obama  signed  into  law  the  Budget  Control  Act  of  2011,  which,  among  other  things,  created  the  Joint  Select
Committee on Deficit Reduction to recommend to Congress proposals in spending reductions. The Joint Select Committee did not
achieve a targeted deficit reduction of at least $1.2 trillion for the years 2013 through 2021, triggering the legislation’s automatic
reduction  to  several  government  programs.  This  includes  reductions  to  Medicare  payments  to  providers  of  2%  per  fiscal  year,
which went into effect on April 1, 2013, following passage of the Bipartisan Budget Act of 2015, and will stay in effect through
2025 unless Congressional action is taken. On January 2, 2013, President Obama signed into law the American Taxpayer Relief
Act  of  2012,  or  the  ATRA,  which,  among  other  things,  further  reduced  Medicare  payments  to  several  providers,  including
hospitals.

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We expect that additional state and federal healthcare reform measures will be adopted in the future, any of which could
limit the amounts that federal and state governments will pay for healthcare products and services, which could result in reduced
demand for our products or additional pricing pressure.

Intellectual Property and Proprietary Rights

We  believe  that  in  order  to  maintain  a  competitive  advantage  in  the  marketplace,  we  must  develop  and  maintain
protection  of  the  proprietary  aspects  of  our  product  lines.  We  rely  on  a  combination  of  trademarks,  trade  secrets,  confidential
information,  copyrights,  patent  rights  and  other  intellectual  property  rights  to  protect  our  intellectual  property.  Our  trademark
portfolio consists of seven registered U.S. trademarks.

In addition, to protect our trade secrets, confidential information and other intellectual property rights, we have entered
into  confidentiality  agreements  with  third  parties,  and  confidential  information  and  invention  assignment  agreements  with
employees, consultants and advisors.

There are risks related to our intellectual property rights. For further details on these risks, see Item 1A — “Risk Factors.”

Employees

As  of  December  31,  2016,  we  had  89  full‑time  employees.  None  of  our  employees  are  represented  by  a  collective
bargaining  agreement,  and  we  have  never  experienced  any  work  stoppage.  We  believe  we  have  good  relations  with
our employees.

Facilities

Our headquarters located in Santa Barbara, California is approximately 20,000 square feet. The term of the lease for our
headquarters  expires  in  February  2020.  We  also  lease  warehouse  space  located  in  Santa  Barbara,  California,  which  is
approximately 10,000 square feet. The term of the lease for our warehouse expires in January 2019.

Legal Proceedings

From time to time, we are involved in legal proceedings and regulatory proceedings arising out of our operations. We establish
reserves for specific liabilities in connection with legal actions that we deem to be probable and estimable. The ability to predict
the  ultimate  outcome  of  such  matters  involves  judgments,  estimates,  and  inherent  uncertainties.  The  actual  outcome  of  such
matters could differ materially from management’s estimates.

Class Action Shareholder Litigation

On September 25, 2015, a lawsuit styled as a class action of the Company’s stockholders was filed in the United States
District Court for the Central District of California. The lawsuit names the Company and certain of our officers as defendants, or
the Sientra Defendants, and alleges violations of Sections 10(b) and 20(a) of the Exchange Act in connection with allegedly false
and misleading statements concerning the Company’s business, operations, and prospects.  The plaintiff seeks damages and an
award  of  reasonable  costs  and  expenses,  including  attorneys’  fees.  On  November  24,  2015,  three  stockholders  (or  groups  of
stockholders) filed motions to appoint lead plaintiff(s) and to approve their selection of lead counsel.  On December 10, 2015, the
court  entered  an  order  appointing  lead  plaintiffs  and  approving  their  selection  of  lead  counsel.    On  February  19,  2016,  lead
plaintiffs filed their consolidated amended complaint, which added claims under Sections 11, 12(a)(2), and 15 of the Securities
Act and named as defendants the underwriters associated with the Company’s follow-on public offering that closed on September
23, 2015, or the Underwriter Defendants. On March 21, 2016, the Sientra Defendants and the Underwriter Defendants each filed a
motion to dismiss, or the Motions to Dismiss, the consolidated amended complaints. On April 20, 2016, lead plaintiffs filed their
opposition to the Motions to Dismiss, and the Sientra Defendants and Underwriter Defendants filed separate replies on May 5,
2016.  On  June  9,  2016,  the  court  granted  in  part  and  denied  in  part  the  Motions  to  Dismiss.    On  July  14,  2016,  the  Sientra
Defendants moved the court to reconsider its June 9, 2016 order and grant the Motions to Dismiss in full. On August 4, 2016, lead
plaintiffs  filed  an  opposition  to  the  motion  for  reconsideration.  On  August  12,  2016,  the  court  denied  the  motion  for
reconsideration, and the Sientra Defendants and the Underwriter Defendants each filed an answer to the consolidated amended
complaint.  

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On  October  28,  November  5,  and  November  19,  2015,  three  lawsuits  styled  as  class  actions  of  the  Company’s
stockholders were filed in the Superior Court of California for the County of San Mateo. The lawsuits name the Company, certain
of  our  officers  and  directors,  and  the  underwriters  associated  with  our  follow-on  public  offering  that  closed  on  September  23,
2015  as  defendants.  The  lawsuits  allege  violations  of  Sections  11,  12(a)(2),  and  15  of  the  Securities  Act  in  connection  with
allegedly  false  and  misleading  statements  in  our  offering  documents  associated  with  the  follow-on  offering  concerning  our
business,  operations,  and  prospects.  The  plaintiffs  seek  damages  and  an  award  of  reasonable  costs  and  expenses,  including
attorneys’ fees. On December 4, 2015, defendants removed all three lawsuits to the United States District Court for the Northern
District  of  California.    On  December  15  and  December  16,  2015,  plaintiffs  filed  motions  to  remand  the  lawsuits  back  to  San
Mateo Superior Court, or Motions to Remand.  On January 19, 2016, defendants filed their opposition to the Motions to Remand,
and plaintiffs filed their reply in support of the Motions to Remand on January 26, 2016. 

On May 20, 2016, the United States District Court for the Northern District of California granted plaintiffs’ Motions to Remand,
and the San Mateo Superior Court received the remanded cases on May 27, 2016.  On July 19, 2016, the San Mateo Superior
Court  consolidated  the  three  lawsuits.    On  August  2,  2016,  plaintiffs  filed  their  consolidated  complaint.  On  August  5,  2016,
defendants  filed  a  motion  to  stay  all  proceedings  in  favor  of  the  class  action  filed  in  the  United  States  District  Court  for  the
Central District of California.

On September 13, 2016, the parties to the actions pending in the San Mateo Superior Court and the United States District Court
for  the  Central  District  of  California  signed  a  memorandum  of  understanding  that  sets  forth  the  material  deal  points  of  a
settlement that covers both actions and includes class-wide relief. On September 13, 2016, and September 20, 2016, respectively,
the  parties  filed  notices  of  settlement  in  both  courts.  On  September  22,  2016,  the  United  States  District  Court  for  the  Central
District  of  California  stayed  that  action  pending  the  court’s  approval  of  a  settlement.  On  September  23,  2016,  the  San  Mateo
Superior Court stayed that action as well as pending the court’s approval of a settlement. 

On  December  20,  2016,  the  plaintiffs  in  the  federal  court  action  filed  a  motion  for  preliminary  approval  of  the  class  action
settlement.  On January 23, 2017, the United States District Court for the Central District of California preliminarily approved the
settlement. A final approval hearing in that court is scheduled for May 22, 2017.  On January 5, 2017, the plaintiffs in the state
court  action  also  filed  a  motion  for  preliminary  approval  of  the  class  action  settlement.    On  February  7,  2017,  the  San  Mateo
Superior Court preliminarily approved the settlement.  A final approval hearing in that court is scheduled for May 31, 2017.  The
settlement is contingent upon final approval by both the San Mateo Superior Court and the United States District Court for the
Central District of California.

As  a  result  of  these  developments,  we  have  determined  that  a  probable  loss  has  been  incurred  and  we  have  recognized  a  net
charge  to  earnings  of  approximately  $1.6  million  within  general  and  administrative  expense,  which  is  comprised  of  the  loss
contingency  of  approximately  $10.9  million,  net  of  expected  insurance  proceeds  of  approximately  $9.4  million.  We  have
classified  the  loss  contingency  as  “legal  settlement  payable”  and  the  expected  insurance  proceeds  as  “insurance  recovery
receivable” on the accompanying condensed balance sheets. While it is possible that we may incur a loss greater than the amounts
recognized in the accompanying interim financial statements, we are unable to determine a range of possible losses greater than
the amount recognized.

Silimed Litigation

On November 6, 2016, Silimed filed a lawsuit in the United States District Court for the Southern District of New York
naming  Sientra  as  the  defendant  and  alleging  breach  of  contract  of  the  Silimed  Agreement,  unfair  competition  and
misappropriation of trade secrets against us.  In its complaint, Silimed alleges that our theft, misuse, and improper disclosure of
Silimed’s  confidential,  proprietary,  and  trade  secret  manufacturing  information  was  done  in  order  for  us  to  develop  our  own
manufacturing capability that we intend to use to manufacture our PMA-approved products.  Silimed is seeking a declaration that
we are in material breach of the Silimed Agreement, a preliminary and permanent injunction to prevent our allegedly wrongful
use  and  disclosure  of  Silimed’s  confidential  and  proprietary  information,  as  well  as  unquantified  compensatory  and  punitive
damages.   On November  15, 2016, Sientra filed  its  answer and counterclaims  for declaratory  judgment in which it denied that
Silimed is entitled to any relief including, among other reasons, because of Silimed’s material breach of the Silimed Agreement
and  Silimed’s  unclean  hands,  and  further  seeks  declaratory  relief  that  Sientra  is  the  owner  of  certain  assets  it  acquired  from
Silimed, Inc. in 2007, that Sientra owns, or is exclusively licensed, to any improvements created since April 2007, that Silimed
lacks any confidential information or proprietary rights under the Silimed Agreement, and that Silimed lacks any relevant trade
secret rights.  On December 9, 2016, Silimed filed a motion to strike the Company’s counterclaims.  Briefing on that motion was
completed on December 30, 2016, and the

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parties are waiting for a decision from the court.  On February 1, 2017, Sientra filed a motion to stay Silimed’s breach of contract
claim  in  light  of  a  demand  for  arbitration  filed  by  Sientra  against  Silimed  on  January  20,  2017  concerning  Silimed’s  material
breaches of the Silimed Agreement, and to further dismiss, or alternatively stay, the unfair competition and misappropriation of
trade secrets claims.  Briefing on that motion was completed on February 22, 2017, and the parties are waiting for a decision from
the court.  On February 3, 2017, the court held an initial pre-trial conference and entered a pre-trial scheduling order which set a
final  pre-trial  conference  date  of  August  3,  2018.    We  believe  that  Silimed’s  claims  are  legally  and  factually  unsupported  and
intend to defend this lawsuit vigorously.

On January 20, 2017, Sientra filed an arbitration demand in the International Center for Dispute Resolution in New York
naming  Silimed  as  the  defendant  and  alleging  material  breach  of  the  Silimed  Agreement,  gross  negligence  and  tortious
interference by Silimed, as well as seeking certain declaratory relief.  Among other things, Sientra alleges that Silimed’s supply
failure constitutes a material breach of the Silimed Agreement, and that such breach was caused by Silimed’s grossly negligent or
other willful conduct related to its regulatory suspensions and the fire at its manufacturing facility.   Silimed filed its answer to
Sientra’s arbitration demand on March 8, 2017.  The parties nominated their party arbitrators on March 13, 2017.

Seasonality

Typically, we experience fluctuations in revenue from quarter to quarter due to seasonality. We believe that breast implant sales
are subject to seasonal fluctuation due to breast augmentation patients’ planning their surgery leading up to the summer season
and in the period around the winter holiday season.

Corporate Information

We  incorporated  in  Delaware  on  August  29,  2003  under  the  name  Juliet  Medical,  Inc.  and  subsequently  changed  our
name to Sientra, Inc. in April 2007. Our principal executive offices are located at 420 South Fairview Avenue, Suite 200, Santa
Barbara,  California,  93117,  and  our  telephone  number  is  (805)  562‑3500.  Our  website  is  located  at  www.sientra.com,  and  our
investor  relations  website  is  located  at  http://investors.sientra.com.  Our  Annual  Reports  on  Form  10-K,  Quarterly  Reports  on
Form 10-Q, reports on Form 8-K and our Proxy Statements are available through our investor relations website, free of charge, as
soon as reasonably possible after we file them with the SEC.

Item 1A.  Risk Factor s

You  should  carefully  consider  the  following  risk  factors,  as  well  as  the  other  information  appearing  elsewhere  in  this  Annual
Report  on Form  10-K,  including  our  financial  statements  and  related  notes,  before  deciding  whether  to  purchase,  hold  or  sell
shares of our common stock. The occurrence of any of the following risks could harm our business, financial condition, results of
operations  and/or  growth  prospects  or  cause  our  actual  results  to  differ  materially  from  those  contained  in  forward-looking
statements  we  have  made  in  this  report  and  those  we  may  make  from  time  to  time.  You  should  consider  all  of  the  risk  factors
described when evaluating our business.

Risks Relating to Our Business and Our Industry

We  may  not  be  able  to  procure  and  qualify  a  new  manufacturer  for  our  silicone  gel  breast  implants  and  other  products
previously manufactured by Silimed.

Our existing manufacturing contract with Silimed expires on its terms on April 1, 2017, and we do not intend to renew
it.  Moreover, our existing inventory of breast implants that were previously manufactured by Silimed is limited and we do not
currently anticipate any future inventory purchases from Silimed.

Although we have entered into a definitive manufacturing agreement with Vesta, Vesta has not yet been qualified as a
manufacturer to source our implants. We recently submitted a PMA supplement to the FDA for the manufacturing of our PMA-
approved implants by Vesta, but the timing of when we may obtain FDA approval, if any, could be subject to delays, some of
which are beyond our control. Moreover, Vesta, or any other alternate manufacturer, would need to be qualified with the FDA,
which  is  an  expensive  and  time-consuming  process.  Any  delays  or  our  inability  to  qualify  Vesta  or  negotiate  a  manufacturing
agreement  and  qualify  another  alternate  manufacturer  could  result  in  a  supply  interruption,  which  would  materially  adversely
affect our business, financial condition and results of operations.

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We  are  in  litigation  with  Silimed,  our  former  sole  source  supplier  of  our  silicone  gel  breast  implants  and  certain  other
products.

On November 6, 2016, Silimed filed a lawsuit in the United States District Court for the Southern District of New York
naming  Sientra  as  the  defendant  and  alleging  breach  of  contract  of  the  Silimed  Agreement,  unfair  competition  and
misappropriation of trade secrets against us.  In its complaint, Silimed alleges that our theft, misuse, and improper disclosure of
Silimed’s  confidential,  proprietary,  and  trade  secret  manufacturing  information  was  done  in  order  for  us  to  develop  our  own
manufacturing capability that we intend to use to manufacture our PMA-approved products.  Silimed is seeking a declaration that
we are in material breach of the Silimed Agreement, a preliminary and permanent injunction to prevent our allegedly wrongful
use  and  disclosure  of  Silimed’s  confidential  and  proprietary  information,  as  well  as  unquantified  compensatory  and  punitive
damages.   On November  15, 2016, Sientra filed  its  answer and counterclaims  for declaratory  judgment in which it denied that
Silimed is entitled to any relief including, among other reasons, because of Silimed’s material breach of the Silimed Agreement
and  Silimed’s  unclean  hands,  and  further  seeks  declaratory  relief  that  Sientra  is  the  owner  of  certain  assets  it  acquired  from
Silimed, Inc. in 2007, that Sientra owns, or is exclusively licensed, to any improvements created since April 2007, that Silimed
lacks any confidential information or proprietary rights under the Silimed Agreement, and that Silimed lacks any relevant trade
secret rights.  On December 9, 2016, Silimed filed a motion to strike the Company’s counterclaims.  Briefing on that motion was
completed on December 30, 2016, and the parties are waiting for a decision from the court.  On February 1, 2017, Sientra filed a
motion to stay Silimed’s breach of contract claim in light of a demand for arbitration filed by Sientra against Silimed on January
20, 2017 concerning Silimed’s material breaches of the Silimed Agreement, and to further dismiss, or alternatively stay, the unfair
competition and misappropriation of trade secrets claims.  Briefing on that motion was completed on February 22, 2017, and the
parties are waiting for a decision from the court. 

We  believe  Silimed’s  claims  are  legally  and  factually  unsupported  and  intend  to  defend  this  lawsuit  vigorously. 
However, we cannot provide assurance that we will be successful in our defense.  If Silimed were to succeed in establishing that
any protectable Silimed IP rights were in fact unlawfully compromised by our new manufacturing relationship with Vesta in a
manner that warrants injunctive relief, we could be subject to an injunction which may delay or otherwise hinder our ability to
procure  and  qualify  an  alternate  manufacturing  supplier  of  our  silicone  gel  breast  implants,  and  we  could  be  required  to  pay
Silimed damages, which risks could have a material adverse effect on our business, results of operations and financial condition
depending on the scope of any injunctive relief and the size of any damage award.  Adverse effects, if any, on our business results
of operations and financial condition with respect to such claims are difficult to assess.  In any event, we expect to incur increased
costs associated with defending this lawsuit and the diversion of our management’s attention from the existing business, which
could also adversely affect our results of operations and financial condition. 

We depend on a positive reaction from our Plastic Surgeons and their patients to successfully re-enter the market after our
voluntary suspension of the sale of Sientra devices manufactured by Silimed.

As a result of the regulatory inquiries into Silimed-manufactured products, between October 9, 2015 and March 1, 2016,
we voluntarily placed a temporary hold on the sale of all Sientra devices manufactured by Silimed and recommended that plastic
surgeons discontinue implanting the devices until further notice. Each of the FDA, ANVISA and MHRA noted that no risks to
patient health have been identified in connection with implanting Silimed-manufactured products, and, accordingly, there is no
need to adopt any procedure or action for those patients who have received them. Additionally, the FDA and ANVISA indicated
that  there  have  been  no  reports  of  adverse  events  related  to  the  alleged  presence  of  particles  on  Silimed-manufactured
products.    Breast  implants  have  stringent  standards  for  manufacturing  and  robust  quality  systems,  but  there  is  no  specific  or
defined standard for surface particles on breast implants. Extensive independent, third-party testing and analyses of our finished
goods  inventory  indicated  no  anticipated  significant  safety  concerns  with  the  use  of  Sientra’s  products,  including  our  breast
implants, consistent with their FDA approval status in 2012. On March 1, 2016, we lifted the temporary hold on the sale of our
devices manufactured by Silimed and informed our Plastic Surgeons of our controlled market re-entry plan designed to optimize
our inventory levels, which continues to be limited.  Although our market re-entry decision was based on extensive testing and
detailed independent third party reviews, we depend on a positive reception from our Plastic Surgeon customers and their patients
to be able to reestablish the market position we had prior to the voluntary suspension.  Our re-entry into the market requires us to
effectively and responsibly educate accounts on the results of our testing and reconfirm our strong clinical data, while providing
the  same  high  levels  of  customer  service  to  which  our  Plastic  Surgeons  are  accustomed.  Our  plastic  surgery  consultants  are
working diligently to solidify the trust and support of all our Plastic Surgeons during this important phase of our market re-entry;

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however, if we are not successful in re-establishing these relationships, adapting our business systems, or competing effectively in
this market, our sales revenues, market share and financial performance will be affected negatively.

Contracting  with  any  third-party  manufacturer  and  supplier  involves  inherent  risks  and  various  factors  outside  our  direct
control that may adversely affect the manufacturing and supply of our breast implants, tissue expanders and other products.

Our  reliance  on  any  third-party  manufacturer,  including  Formulated  Solutions,  LLC,  or  Formulated  Solutions,  which
supplies our bioCorneum® scar management products, SiMatrix, a Vesta subsidiary that supplies the tissue expanders we recently
acquired from SSP, and Vesta or any future third-party manufacturer we procure and qualify for the manufacture of our breast
implants  involves  a  number  of  risks.  Manufacturing  and  supply  of  our  breast  implants,  tissue  expanders  and  other  products  is
technically challenging. Changes that our manufacturers may make outside the purview of our direct control can have an impact
on our processes and quality, as well as the successful delivery of products to Plastic Surgeons.  Mistakes and mishandling are not
uncommon and can affect production and supply. Additionally, there are only a few suppliers of medical-grade silicone available
, and if these suppliers become unable or unwilling to supply medical-grade silicone to Vesta, Formulated Solutions, SiMatrix or
any other manufacturer that we may engage with , an alternate supply of medical-grade silicone may not be able to be found in a
timely manner .  Some of the additional risks with relying on third-party manufacturers and suppliers include:

·

our products may not be manufactured in accordance with agreed upon specifications or in compliance with regulatory
requirements  or  cGMP,  or  the  manufacturing  facilities  may  not  be  able  to  maintain  compliance  with  regulatory
requirements or cGMP, which could negatively affect the safety or efficacy of our products or cause delays in shipments
of our products;

· we may not be able to timely respond to unanticipated changes in customer orders, and if orders do not match forecasts,

we may have excess or inadequate inventory of materials and components;

·

our products may be mishandled while in production or in preparation for transit;

· we are subject to transportation and import and export risk, particularly given the global nature of our supply chain;

·

·

·

·

·

·

·

the third-party manufacturer may discontinue manufacturing and supplying products to us for risk management reasons;

the  third-party  manufacturer  may  lose  access  to  critical  services  and  components,  resulting  in  an  interruption  in  the
manufacturing or shipment of our products;

the  third-party  manufacturer  may  encounter  financial  or  other  hardships  unrelated  to  us and  our  demand  for  products,
which could inhibit our ability to fulfill our orders;

there  may  be  delays  in  analytical  results  or  failure  of  analytical  techniques  that  we  depend  on  for  quality  control  and
release of products;

natural disasters, labor disputes, financial distress, lack of raw material supply, issues with facilities and equipment or
other forms of disruption to business operations affecting our manufacturer or its suppliers may occur;

latent defects may become apparent after products have been released and which may result in a recall of such products;
and

there are  inherent  risks  if  we  contract  with  manufacturers  located  outside  of  the  United  States,  including  the  risks  of
economic change, recession, labor strikes or disruptions, political turmoil, new or changing tariffs or trade barriers, new
or  different  restrictions  on  importing  or  exporting,  civil  unrest,  infrastructure  failure,  cultural  differences  in  doing
business, lack of contract enforceability, lack of protection for intellectual property, war and terrorism.

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The materialization of any of these risks and limitations inherent in a third-party manufacturing contractual relationship
could  significantly  increase  our  costs,  impair  our  ability  to  generate  net  sales,  and  adversely  affect  market  acceptance  of  our
products and customers  may instead  purchase or use our competitors’  products, which could materially  adversely  and severely
affect our business, financial condition and results of operations.

We have incurred significant net operating losses since inception and cannot assure you that we will achieve profitability.

Since  our  inception,  we  have  incurred  significant  net  operating  losses.    As  of  December  31,  2016,  we  had  an
accumulated  deficit  of  $215.4  million.  To  date,  we  have  financed  our  operations  primarily  through  sales  of  preferred  stock,
borrowings under our term loans, sales of our products since 2012, our initial public offering and our follow-on public offering of
our  common  stock.    We  have  devoted  substantially  all  of  our  resources  to  the  acquisition  and  clinical  development  of  our
products,  the  commercial  launch  of  our  products,  the  development  of  a  sales  and  marketing  team  and  the  assembly  of  a
management team to manage our business.

For the year ended December 31, 2016, our net loss was $40.2 million. The extent of our future operating losses and the
timing of profitability are uncertain, especially in light of our inventory supply issues. We will need to generate significant sales
to achieve  profitability,  and we might  not be able  to do so.  Even if  we do generate  significant  sales,  we might  not be able  to
achieve, sustain or increase profitability on a quarterly or annual basis in the future.  If our sales grow more slowly than we have
forecasted,  or  if  our  operating  expenses  exceed  our  forecasts,  our  financial  performance  and  results  of  operations  will  be
adversely affected.

Our future profitability depends on the success of our Breast Products.

Our  Breast  Products  have  historically  accounted  for  substantially  all  of  our  net  sales  and  we  expect  our  Breast  Products  to
continue to be a substantial majority of our net sales. Our inability to manage our inventory supply issues, the inability to qualify
Vesta or another third party as an alternate manufacturer, the potential loss of market acceptance of our Breast Products, or any
adverse  rulings  by  regulatory  authorities,  any  adverse  finding  in  the  Silimed  Litigation,  any  adverse  publicity  or  other  adverse
events relating to us or our Breast Products, or the introduction of competitive products by our competitors and other third parties,
would adversely affect our business, financial condition and results of operations.

Any negative publicity concerning our products could harm our business and reputation and negatively impact our financial
results.

The responses of potential patients, physicians, the news media, legislative and regulatory bodies and others to information about
complications  or  alleged  complications  of  our  products  could  result  in  negative  publicity  and  could  materially  reduce  market
acceptance of our products.  These responses or any investigations and potential resulting negative publicity may have a material
adverse effect on our business and reputation and negatively impact our financial condition, results of operations or the market
price of our common  stock.  In addition, significant  negative  publicity  could result in an increased  number of product liability
claims against us.

We may not realize the benefits of our recent acquisitions which may be subject to additional risks and uncertainties.

In  March  2016,  we  acquired  bioCorneum®,  an  advanced  silicone  gel  scar  management  product  from  Enaltus.    In
November 2016, we acquired  certain  assets,  consisting  of  the  Dermaspan™,  Softspan™,  and  AlloX2®  tissue  expanders,  from
SSP.  These acquisitions were made in an effort to add differentiated and complementary products that serve the needs of Plastic
Surgeons while diversifying our business mix.

Our acquisition of bioCorneum® involves risks and uncertainties including that we have limited experience in the scar
management  industry,  our  management’s  attention  may  be  diverted  from  our  existing  business  as  we  attempt  to  integrate
bioCorneum®  and  the  integration  may  not  be  successful.  Additionally,  bioCorneum®  is  an  over-the-counter  pharmaceutical
registered with the FDA, and there may be risks associated with the use of bioCorneum® including skin irritation, rash, itching or
accidental application into the eye or ingestion. We also rely on Formulated Solutions as our sole source, third-party manufacturer
of bioCorneum® and if Formulated Solutions becomes unable or unwilling to supply bioCorneum®, we may not be able to find
an alternate supplier in a timely manner.

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Our acquisition of the tissue expanders from SSP also involves risk and uncertainties including that our management’s
attention  may  be  diverted  from  our  existing  business  as  we  integrate  the  Dermaspan  ™  ,  Softspan  ™,  and  AlloX2®  tissue
expanders;  and  the  integration  of  these  products  into  our  existing  business  may  not  be  successful  or  we  may  not  achieve  the
anticipated benefits.  Additionally, these SSP products are currently manufactured and supplied by SiMatrix, a Vesta subsidiary,
and if SiMatrix becomes unable or unwilling to supply these products, we may not be able to find an alternate supplier in a timely
manner.    Our  existing  manufacturing  contract  with  SiMatrix  expires  on  its  terms  on  November  1,  2017,  and  there  can  be  no
assurance that SiMatrix will agree to continue to manufacture and supply such products after the expiration of our contract or they
may impose increased pricing terms if the contract is renegotiated or renewed.

We do not know if we will be able to successfully integrate these recently acquired products into our existing business,
or  whether  unforeseen  risks  associated  with  their  uses  will  materialize.  Our  inability  to  integrate  these  acquired  products
effectively or realize anticipated synergies may adversely affect our business, financial condition and results of operations.

We may not realize the benefits of partnerships with other companies, acquisitions of complementary products or technologies
or other strategic alternatives.

In addition to our recent acquisitions of bioCorneum® and the tissue expanders from SSP, from time to time, we may consider
opportunities  to  partner  with  or  acquire  other  businesses,  products  or  technologies  that  may  enhance  our  product  platform  or
technology,  expand  the  breadth  of  our  markets  or  customer  base  or  advance  our  business  strategies.  Potential  partnerships  or
acquisitions involve numerous risks, including:

·

integration of the acquired products or technologies with our existing business;

· maintenance of uniform standards, procedures, controls and policies;

·

·

·

·

unanticipated costs associated with partnerships or acquisitions;

diversion of management’s attention from our existing business;

uncertainties associated with entering new markets in which we have limited or no experience; and

increased  legal  and  accounting  costs  relating  to  the  partnerships  or  acquisitions  or  compliance  with  regulatory
matters.

We  do  not  know  if  we  will  be  able  to  identify  partnerships  or  acquisitions  we  deem  suitable,  whether  we  will  be  able  to
successfully  complete  any  such  partnerships  or  acquisitions  on  favorable  terms  or  at  all,  or  whether  we  will  be  able  to
successfully  integrate  any partnered  or acquired  products  or technologies.   Our potential  inability  to  integrate  any  partnered  or
acquired  products  or  technologies  effectively  or  realize  anticipated  synergies  may  adversely  affect  our  business,  financial
condition and results of operations.

We have a limited operating history and may face difficulties encountered by companies early in their commercialization in
competitive and rapidly evolving markets.

We  commenced  operations  in  2007  and  began  commercializing  silicone  gel  breast  implants  in  the  second  quarter  of
2012.  Accordingly, we have a limited operating history upon which to evaluate our business and forecast our future net sales and
operating  results.    In  assessing  our  business  prospects,  you  should  consider  the  various  risks  and  difficulties  frequently
encountered by companies early in their commercialization in competitive markets, particularly companies that develop and sell
medical devices.  These risks include our ability to:

·

·

implement and execute our business strategy;

expand and improve the productivity of our sales force and marketing programs to grow sales of our existing and
proposed products;

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·

increase awareness of our brand and build loyalty among Plastic Surgeons;

· manage expanding operations;

·

·

·

·

·

respond effectively to competitive pressures and developments;

enhance our existing products and develop new products;

obtain regulatory clearance or approval to enhance our existing products and commercialize new products;

perform clinical trials with respect to our existing products and any new products; and

attract, retain and motivate qualified personnel in various areas of our business.

Due to our limited operating history, we may not have the institutional knowledge or experience to be able to effectively address
these and other risks that we may face.  In addition, we may not be able to develop insights into trends that could emerge and
negatively affect our business and may fail to respond effectively to those trends.  As a result of these or other risks, we may not
be  able  to  execute  key  components  of  our  business  strategy,  and  our  business,  financial  condition  and  operating  results  may
suffer.

If we fail to compete effectively against our competitors, both of which have significantly greater resources than we have, our
net sales and operating results may be negatively affected.

Our industry is intensely competitive and subject to rapid change from the introduction of new products, technologies and other
activities of industry participants.  Our competitors, Mentor, a wholly owned subsidiary of Johnson & Johnson, and Allergan are
well-capitalized global pharmaceutical companies that have been the market leaders for many years and have the majority share
of  the  breast  implant  market  in  the  United  States.    These  competitors  also  enjoy  several  competitive  advantages  over  us,
including:

·

·

·

·

·

·

·

greater financial and human resources for sales, marketing and product development;

established relationships with health care providers and third-party payors;

established  reputations  and  name  recognition  among  health  care  providers  and  other  key  opinion  leaders  in  the
plastic surgery industry;

in some cases, an established base of long-time customers;

products supported by long-term clinical data;

larger and more established distribution networks;

greater ability to cross-sell products; and

· more experience  in conducting research  and development,  manufacturing,  performing  clinical  trials  and obtaining

regulatory approval or clearance.

If we fail to compete effectively against our competitors, our net sales and operating results may be negatively affected.

Pricing pressure from customers and our competitors may impact our ability to sell our products at prices necessary to support
our current business strategies.

Our  2012  entry  into  the  U.S.  breast  implant  market  represented  a  significant  expansion  of  the  breast  implant  choices  and
technologies  available  in  the  United  States.    As  a  result  of  our  entry  into  the  U.S.  breast  implant  market,  our  competitors
intensified competitive pricing pressure for traditional round-shaped breast implants.  If we are not successful

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in convincing customers or third-party payors of our breast implants as compared to our competitors’ products, third-party payors
may not cover or adequately reimburse our products and customers may choose our competitors’ products.

The long-term safety of our products has not fully been established and our breast implants are currently under study in our
PMA post-approval studies, which could reveal unanticipated complications.

We have  been  market  ing  our  silicone  gel  breast  implants  in  the  United  States  with  pre-market  approval  from  the  FDA  since
2012. However, there could still be unanticipated complications or unforeseen health consequences of being implanted with our
silicone gel breast implants over the long-term (defined as 10 years or more). Additionally, we rely on our clinical data to make
favorable  comparisons  of  our  product  to  our  competitive  products,  and  our  longer-term  data  may  change  over  time.  Further,
future  studies  or  clinical  experience  may  indicate  that  treatment  with  our  products  is  not  differentiated  to  treatment  with
competitive  products.  Such  results  could  slow  the  adoption  of  our  products  and  significantly  reduce  our  sales,  which  could
prevent us from achieving our forecasted sales targets or achieving or sustaining profitability. Moreover, if long-term results and
experience  indicate  that  our  products  cause  unexpected  or  serious  complications,  we  could  be  subject  to  mandatory  product
recalls, suspension or withdrawal of clearance or approval by the FDA or other applicable regulatory bodies and significant legal
liability.

Among  the  long-term  health  risks  of  breast  implants  which  are  being  studied  is  the  possible  association  between  breast
implants and a rare form of cancer called anaplastic large-cell lymphoma.

In January 2011, the FDA indicated that there was a possible association between saline and silicone gel breast implants
and anaplastic large-cell lymphoma, or ALCL. Since our FDA approval in 2012, Sientra’s breast-implant product label, which is
approved by the FDA, has been required to contain a description of ALCL as a possible, though rare, outcome. Since its report in
January  2011,  the  FDA  continued  to  gather  information  about  ALCL  in  women  with  breast  implants  through  the  review  of
medical device reports, review of medical literature, and collaboration with international regulators, scientific experts, ASPS, and
other  organizations.  In  January  2016,  the  FDA  reiterated,  after  a  review  of  information  since  2011,  that  ALCL  is  a  very  rare
condition and the FDA recommended the same measures as it had before for health care providers and patients.  Further studies or
clinical  experience  may  indicate  that  breast  implants,  including  our  products,  expose  individuals  to  a  more  substantial  risk  of
developing ALCL or other unexpected complications. As a result, we may be exposed to increased regulatory scrutiny, negative
publicity  and  lawsuits  from  any  individual  who  may  develop  ALCL  after  using  our  products,  any  of  which  could  have  a
significant  negative  impact  on  our  results  of  operations  or  financial  condition.  Moreover,  if  long-term  results  and  clinical
experience  indicate  that  our  products  cause  unexpected  or  serious  complications,  we  could  be  subject  to  mandatory  product
recalls, suspension or withdrawal of regulatory clearances and approvals and significant legal liability.

If we are unable to train Plastic Surgeons on the safe and appropriate use of our products, we may be unable to achieve our
expected growth.

An  important  part  of  our  sales  process  includes  the  ability  to  educate  Plastic  Surgeons  about  the  availability  of  anatomically-
shaped breast implants and train Plastic Surgeons on the safe and appropriate use of our products.  If we become unable to attract
potential  new  Plastic  Surgeon  customers  to  our  education  and  training  programs,  we  may  be  unable  to  achieve  our  expected
growth.

There is a learning process involved for Plastic Surgeons to become proficient in the use of our anatomically-shaped products.  It
is critical to the success of our commercialization efforts to train a sufficient number of Plastic Surgeons and provide them with
adequate  instruction  in  the  appropriate  use  of  our  products  via  preceptorships  and  additional  demonstration  surgeries.    This
training process may take longer than expected and may therefore affect our ability to increase sales.  Following completion of
training, we rely on the trained Plastic Surgeons to advocate the benefits of our products in the marketplace.  Convincing Plastic
Surgeons to dedicate the time and energy necessary for adequate training is challenging, and we cannot assure you that we will be
successful in these efforts.  If Plastic Surgeons are not properly trained, they may misuse or ineffectively use our products.  This
may also result in, among other things, unsatisfactory patient outcomes, patient injury, negative publicity or lawsuits against us,
any of which could have an adverse effect on our business and reputation.

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If we are unable to continue to enhance our existing Breast Products and develop and market new products that respond to
customer needs and preferences and achieve market acceptance, we may experience a decrease in demand for our products
and our business could suffer.

We  may  not  be  able  to  compete  effectively  with  our  competitors,  and  ultimately  satisfy  the  needs  and  preferences  of  our
customers,  unless  we  can  continue  to  enhance  existing  products  and  develop  and  market  new  innovative  products.    Product
development requires the investment of significant financial, technological and other resources.  Product improvements and new
product  introductions  also  require  significant  planning,  design,  development  and  testing  at  the  technological,  product  and
manufacturing  process  levels  and  we  may  not  be  able  to  timely  develop  product  improvements  or  new  products.    Our
competitors’ new products may beat our products to market, be more effective with new features, obtain better market acceptance
or render our products obsolete.  Any new or modified products that we develop may not receive clearance or approval from the
FDA, or achieve market acceptance or otherwise generate any meaningful sales or profits for us relative to our expectations based
on,  among  other  things,  existing  and  anticipated  investments  in  manufacturing  capacity  and  commitments  to  fund  advertising,
marketing, promotional programs and research and development.

If  changes  in  the  economy  and  consumer  spending  reduce  consumer  demand  for  our  products,  our  sales  and  profitability
would suffer.

We are subject to the risks arising from adverse changes in general economic and market conditions.  Certain elective procedures,
such as breast augmentation and body contouring, are typically not covered by insurance.  Adverse changes in the economy may
cause consumers to reassess their spending choices and reduce the demand for these surgeries and could have an adverse effect on
consumer spending.  This shift could have an adverse effect on our net sales.  Furthermore, consumer preferences and trends may
shift  due  to  a  variety  of  factors,  including  changes  in  demographic  and  social  trends,  public  health  initiatives  and  product
innovations, which may reduce consumer demand for our products.

We are required to maintain high levels of inventory, which could consume a significant amount of our resources and reduce
our cash flows.

We need to maintain substantial levels of inventory to protect ourselves from supply interruptions, provide our customers with a
wide range of shapes and sizes of our breast implants, and account for the high return rates we experience as Plastic Surgeons
typically  order  our  products  in  multiple  sizes  for  a  single  surgery  and  then  return  what  they  do  not  use.    As  a  result  of  our
substantial  inventory  levels,  we  are  subject  to  the  risk  that  a  substantial  portion  of  our  inventory  becomes  obsolete.  The
materialization of any of these risks may have a material adverse effect on our earnings and cash flows due to the resulting costs
associated with the inventory impairment charges and costs required to replace such inventory.  Additionally, our ability to find
an alternate  supplier in a timely  manner, may affect  our ability  to maintain  the level of inventory supply we require to protect
ourselves from supply interruptions that could have an unfavorable impact on our net sales.

Any disruption at our facilities could adversely affect our business and operating results.

Our principal offices are located in Santa Barbara, California.  Substantially all of our operations are conducted at this location,
including  customer  service,  development  and  management  and  administrative  functions.    Substantially  all  of  our  inventory  of
finished goods is held at a second location in Santa Barbara, California. Despite our efforts to safeguard our facilities, including
acquiring insurance, adopting health and safety protocols and utilizing off-site storage of computer data, vandalism, terrorism or a
natural  or  other  disaster,  such  as  an  earthquake,  fire  or  flood,  could  damage  or  destroy  our  inventory  of  finished  goods,  cause
substantial delays in our operations, result in the loss of key information and cause us to incur additional expenses.  Our insurance
may not cover our losses in any particular case.  In addition, regardless of the level of insurance coverage, damage to our facilities
may have a material adverse effect on our business, financial condition and operating results.

If  there  are  significant  disruptions  in  our  information  technology  systems,  our  business,  financial  condition  and  operating
results could be adversely affected.

The efficient operation of our business depends on our information technology systems.  We rely on our information technology
systems  to  effectively  manage  sales  and  marketing  data,  accounting  and  financial  functions,  inventory,  product  development
tasks, clinical data, and customer service and technical support functions.  Our information

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technology systems are vulnerable to damage or interruption from earthquakes, fires, floods and other natural disasters, terrorist
attacks, computer viruses or hackers, power losses, and computer system or data network failures.  In addition, a variety of our
software  systems  are  cloud-based  data  management  applications  hosted  by  third-party  service  providers  whose  security  and
information technology systems are subject to similar risks.

The failure of our or our service providers’ information technology could disrupt our entire operation or result in decreased sales,
increased  overhead  costs  and  product  shortages,  all  of  which  could  have  a  material  adverse  effect  on  our  reputation,  business,
financial condition and operating results.

We  may  be  adversely  affected  by  earthquakes  or  other  natural  disasters  and  our  business  continuity  and  disaster  recovery
plans may not adequately protect us from a serious disaster.

Our corporate headquarters and certain other facilities are located in Santa Barbara, California, which in the past has experienced
both severe earthquakes and wildfires.  We do not carry earthquake insurance.  Earthquakes, wildfires or other natural disasters
could severely disrupt our operations, and have a material adverse effect on our business, results of operations, financial condition
and prospects.

If  a  natural  disaster,  power  outage  or  other  event  occurred  that  prevented  us  from  using  all  or  a  significant  portion  of  our
headquarters,  that  damaged  critical  infrastructure,  such  as  our  enterprise  financial  systems  or  manufacturing  resource  planning
and enterprise quality systems, or that otherwise disrupted operations, it may be difficult or, in certain cases, impossible for us to
continue  our  business  for  a  substantial  period  of  time.    The  disaster  recovery  and  business  continuity  plans  we  have  in  place
currently  are  limited  and  are  unlikely  to  prove  adequate  in  the  event  of  a  serious  disaster  or  similar  event.    We  may  incur
substantial expenses as a result of the limited nature of our disaster recovery and business continuity plans, which, particularly
when taken together with our lack of earthquake insurance, could have a material adverse effect on our business.

Failure to obtain hospital or group purchasing organization contracts could have a material adverse effect on our financial
condition and operating results.

A portion of our net sales is derived from sales to hospitals.  Many hospital customers, through the contracting process, limit the
number of breast implant suppliers that may sell to their institution.  Hospitals may choose to contract with our competitors who
have a broader range of products that can be used in a wider variety of procedures or our competitors may actively position their
broader product portfolios against us during the hospital contracting process.  Any limitations on the number of hospitals to which
we can sell our products may significantly restrict our ability to grow.

In  addition,  contracts  with  hospitals  and  group  purchasing  organizations,  or  GPOs,  often  have  complex  insurance  and
indemnification requirements, which may not be beneficial to us, or we may not be able to successfully negotiate contracts with a
substantial  number  of  hospitals  and  GPOs  at  all,  which  could  adversely  affect  our  business,  financial  condition  and  results  of
operations.

Our  business  could  suffer  if  we  lose  the  services  of  key  personnel  or  are  unable  to  attract  and  retain  additional  qualified
personnel.

We are dependent upon the continued services of key personnel, including members of our executive management team who have
extensive experience in our industry. The loss of any one of these individuals could disrupt our operations or our strategic plans.
Additionally,  our  future  success  will  depend  on,  among  other  things,  our  ability  to  continue  to  hire  and  retain  the  necessary
qualified  sales,  marketing  and  managerial  personnel,  for  whom  we  compete  with  numerous  other  companies,  academic
institutions and organizations. If we lose additional key employees, if we are unable to attract or retain other qualified personnel,
or if our management team is not able to effectively manage us through these events, our business, financial condition, and results
of operations may be adversely affected.

We will need to increase the size of our organization, and we may experience difficulties in managing growth.

As of December 31, 2016, we had approximately 89 full-time employees.  Our management and personnel, and the systems and
facilities  we currently have in place, may not be adequate to support future growth.  Effectively  executing our growth strategy
requires that we increase net sales through sales and marketing activities, recruit and retain additional employees and continue to
improve our operational, financial and management controls, reporting systems and procedures.

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If we are not able to effectively expand our organization in these ways, we may not be able to successfully execute our growth
strategy, and our business, financial condition and results of operations may suffer.

Risks Related to Our Financial Results

Our quarterly net sales and operating results are unpredictable and may fluctuate significantly from quarter to quarter due to
factors  outside  our  control,  which  could  adversely  affect  our  business,  results  of  operations  and  the  trading  price  of  our
common stock.

Our net sales and operating results may vary significantly from quarter to quarter and year to year due to a number of factors,
many of which are outside of our control and any of which may cause our stock price to fluctuate.  Our net sales and results of
operations will be affected by numerous factors, including:

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

·

the  timing  and  availability  of  alternative  manufacturing  sources  to  supply  our  silicone  gel  breast  implants  and
certain other products;

our ability to integrate and achieve the anticipated benefits of our recent acquisitions of bioCorneum® and the tissue
expanders from SSP;

the impact of the buying patterns of patients and seasonal cycles in consumer spending;

our ability to drive increased sales of anatomically-shaped breast implants products;

our ability to establish and maintain an effective and dedicated sales organization;

pricing pressure applicable to our products, including adverse third-party coverage and reimbursement outcomes;

results of clinical research and trials on our existing products;

the impact of the recent regulatory inquiries of Silimed on our brand and reputation;

timing of our research and development activities and initiatives;

the mix of our products sold due to different profit margins among our products;

timing of new product offerings, acquisitions, licenses or other significant events by us or our competitors;

the ability of our suppliers to timely provide us with an adequate supply of products;

the evolving product offerings of our competitors;

regulatory approvals and legislative changes affecting the products we may offer or those of our competitors;

increased labor and related costs;

interruption in the manufacturing or distribution of our products;

the effect of competing technological, industry and market developments;

changes in our ability to obtain regulatory clearance or approval for our products;

our ability to expand the geographic reach of our sales and marketing efforts; and

our ability to successfully defend against the claims asserted in the Silimed Litigation.

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Many  of  the  products  we  may  seek  to  develop  and  introduce  in  the  future  will  require  FDA  approval  or  clearance  before
commercialization in the United States, and commercialization of such products outside of the United States would likely require
additional  regulatory  approvals,  CE  Certificates  of  Conformity  and  export  licenses.    As  a  result,  it  will  be  difficult  for  us  to
forecast demand for these products with any degree of certainty.  In addition, we will be increasing our operating expenses as we
expand our commercial capabilities.  Accordingly, we may experience significant, unanticipated quarterly losses.  If our quarterly
or annual operating results fall below the expectations of investors or securities analysts, the price of our common stock could
decline substantially.  Furthermore, any quarterly or annual fluctuations in our operating results may, in turn, cause the price of
our common stock to fluctuate substantially.  We believe that quarterly comparisons of our financial results are not necessarily
meaningful and should not be relied upon as an indication of our future performance.

Our future capital needs are uncertain and we may need to raise additional funds in the future, and these funds may not be
available on acceptable terms or at all.

As of December 31, 2016, we had $67.2 million in cash and cash equivalents. We believe that our available cash on hand will be
sufficient  to  satisfy  our  liquidity  requirements  for  at  least  the  next  12  months.    However,  the  planned  growth  of  our  business,
including  the  expansion  of  our  sales  force  and  marketing  programs,  and  research  and  development  activities,  and  potential
partnerships or strategic acquisitions could significantly increase our expenses.  In addition, we expect expenses we may incur in
connection with reestablishing our inventory supply,   expenses we may incur defending against litigation claims, including the
Silimed Litigation may have a material effect on our future cash outflows and our financial condition.

Our future capital requirements will depend on many factors, including:

·

·

·

·

·

·

·

·

·

the timing and availability of alternative manufacturing sources and costs associated with procuring and qualifying
such manufacturing capacity;

net sales generated by our silicone gel breast implants and tissue expanders and any other future products that we
may develop and commercialize;

expenses  we  incur  in  connection  with  the  Silimed  Litigation,  other  potential  litigation  or  governmental
investigations;

costs associated with expanding our sales force and marketing programs;

cost associated with developing and commercializing our proposed products or technologies;

cost of obtaining and maintaining regulatory clearance or approval for our current or future products;

cost of ongoing compliance with regulatory requirements;

anticipated or unanticipated capital expenditures; and

unanticipated general and administrative expenses.

As a result of these and other factors, we do not know whether and the extent to which we may be required to raise additional
capital.  We may in the future seek additional capital from public or private offerings of our capital stock, borrowings under term
loans or other sources.  If we issue equity or debt securities to raise additional funds, our existing stockholders may experience
dilution,  and  the  new  equity  or  debt  securities  may  have  rights,  preferences  and  privileges  senior  to  those  of  our  existing
stockholders.    In  addition,  if  we  raise  additional  funds  through  collaborations,  licensing,  joint  ventures,  strategic  alliances,
partnership arrangements or other similar arrangements, it may be necessary to relinquish valuable rights to our potential future
products or proprietary technologies, or grant licenses on terms that are not favorable to us.

If we are unable to raise additional capital, we may not be able to expand our sales force and marketing programs, enhance our
current products or develop new products, take advantage of future opportunities, or respond to competitive

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pressures, changes in supplier relationships, or unanticipated changes in customer demand.  Any of these events could adversely
affect  our  ability  to  achieve  our  strategic  objectives,  which  could  have  a  material  adverse  effect  on  our  business,  financial
condition and operating results.

Our loan agreement contains restrictive covenants that may limit our operating flexibility .

We  recently  entered  into  a  Loan  and  Security  Agreement,  or  the  Loan  Agreement,  with  Silicon  Valley  Bank.  The  Loan
Agreement  contains  certain  restrictive  covenants  including  covenants  against  the  occurrence  of  a  change  in  control,  financial
reporting  obligations,  and  certain  limitations  on  indebtedness,  liens,  investments,  distributions  (including  dividends),  collateral,
mergers or acquisitions, taxes, corporate changes, and deposit accounts, among others. We therefore may not be able to engage in
any  of  the  foregoing  transactions  unless  we  obtain  the  consent  of  the  lender  or  terminate  the  Loan  Agreement.    There  is  no
guarantee  that  we  will  be  able  to  pay  the  principal  and  interest  under  the  Loan  Agreement  or  that  future  working  capital,
borrowings or equity  financing  will be available  to repay  or refinance  any amounts  outstanding under the Loan Agreement.  In
addition,  we  may  enter  into  debt  agreements  in  the  future  that  may  contain  similar  or  more  burdensome  terms  and  covenants,
including financial covenants.

Our ability to use net operating losses to offset future taxable income may be subject to certain limitations.

As  of  December  31,  2016,  we  had  federal  net  operating  loss  carryforwards,  or  NOLs, of  approximately  $170.9 million,  which
begin expiring in 2027, if not utilized to offset taxable income.  In general, under Section 382 of the Internal Revenue Code of
1986,  as  amended,  or  the  Code,  a  corporation  that  undergoes  an  “ownership  change”  is  subject  to  limitations  on  its  ability  to
utilize its pre-change NOLs to offset future taxable income.  In general, an “ownership change” occurs if there is a cumulative
change in our ownership by “5% shareholders” that exceeds 50 percentage points over a rolling three-year period.  Our existing
NOLs may be subject to limitations arising from previous ownership changes, and if we undergo one or more ownership changes
in  connection  with  future  transactions  in  our  stock,  our  ability  to  utilize  NOLs  could  be  further  limited  by  Section  382  of  the
Code.  As a result of these limitations, we may not be able to utilize a material portion of the NOLs reflected on our balance sheet
and for this reason, we have fully reserved against the value of our NOLs on our balance sheet. We have not completed a Section
382 analysis to determine if an ownership change has occurred. Until such analysis is completed, we cannot be sure that the full
amount of the existing federal NOLs will be available to us, even if we do generate taxable income before their expiration.

Future changes in financial accounting standards may cause adverse unexpected net sales or expense fluctuations and affect
our reported results of operations.

A  change  in  accounting  standards  could  have  a  significant  effect  on  our  reported  results  and  may  even  affect  our  reporting  of
transactions  completed  before  the  change  is  effective.    New  pronouncements  and  varying  interpretations  of  existing
pronouncements have occurred and may occur in the future.  Changes to existing rules or current practices may adversely affect
our reported financial results of our business.

Risks Related to Our Intellectual Property and Potential Litigation

If  our  intellectual  property  rights  do  not  adequately  protect  our  products  or  technologies,  others  could  compete  against  us
more directly, which would hurt our profitability.

Our success depends in part on our ability to protect our intellectual property rights.  We rely on a combination of trademarks,
trade  secrets,  confidential  information,  copyrights,  patent  rights  and  other  intellectual  property  rights  to  protect  our  intellectual
property.   In addition, to protect our trade secrets, confidential information and other intellectual property rights, we have entered
into  confidentiality  agreements  with  third  parties,  and  confidential  information  and  invention  assignment  agreements  with
employees, consultants and advisors.  However, these agreements may not provide sufficient protection or adequate remedies for
violation  of  our  rights  in  the  event  of  unauthorized  use  or  disclosure  of  confidential  and  proprietary  information.    Without
additional  protection  under  the  patent  or  other  intellectual  property  laws,  such  unauthorized  use  or  disclosure  may  enable
competitors  to  duplicate  or  surpass  our  technological  achievements.    Moreover,  the  laws  of  certain  foreign  countries  do  not
recognize intellectual property rights or protect them to the same extent as do the laws of the United States.  Failure to protect our
proprietary rights could seriously impair our competitive position.

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The medical device industry is characterized by patent and other intellectual property litigation and we have and could become
subject to litigation that could be costly, result in the diversion of management’s time and efforts, require us to pay damages or
prevent us from marketing our existing or future products.

Our  commercial  success  will  depend  in  part  on  not  infringing  the  patents  or  violating  the  other  proprietary  rights  of
others.  Significant litigation regarding patent rights occurs in our industry.  Our competitors in both the United States and abroad,
many  of  which  have  substantially  greater  resources  and  have  made  substantial  investments  in  patent  portfolios  and  competing
technologies,  may  have  applied  for  or  obtained  or  may  in  the  future  apply  for  and  obtain,  patents  that  will  prevent,  limit  or
otherwise  interfere  with  our  ability  to  make,  use  and  sell  our  products.    Absent  specific  circumstances,  we  do  not  generally
conduct independent reviews of patents issued to third parties.  We may not be aware of whether our products do or will infringe
existing or future patents.  In addition, patent applications in the United States and elsewhere can be pending for many years, and
may be confidential for 18 months or more after filing, and because pending patent claims can be revised before issuance, there
may be applications of others now pending of which we are unaware that may later result in issued patents that will prevent, limit
or otherwise interfere with our ability to make, use or sell our products.  We may not be aware of patents that have already issued
that a third party might assert are infringed by our products.  It is also possible that patents of which we are aware, but which we
do  not  believe  are  relevant  to  our  product  candidates,  could  nevertheless  be  found  to  be  infringed  by  our  products.    The  large
number of patents, the rapid rate of new patent applications and issuances, the complexities of the technology involved and the
uncertainty of litigation increase the risk of business assets and management’s attention being diverted to patent litigation.  In the
future, we may receive communications from various industry participants alleging our infringement of their patents, trade secrets
or  other  intellectual  property  rights  and/or  offering  licenses  to  such  intellectual  property.    Any  lawsuits  resulting  from  such
allegations could subject us to significant liability for damages and invalidate our proprietary rights, even if they lack merit.  Any
existing or potential intellectual property litigation also could force us to do one or more of the following:

·

·

·

·

·

·

·

stop making, selling or using products or technologies that allegedly infringe the asserted intellectual property;

lose  the  opportunity  to  license  our  technology  to  others  or  to  collect  royalty  payments  based  upon  successful
protection and assertion of our intellectual property rights against others;

incur significant legal expenses;

pay  substantial  damages  or  royalties  to  the  party  whose  intellectual  property  rights  we  may  be  found  to  be
infringing;

pay the attorney fees and costs of litigation to the party whose intellectual property rights we may be found to be
infringing;

redesign those products that contain the allegedly infringing intellectual property, which could be costly, disruptive
and/or infeasible; or

attempt  to  obtain  a  license  to  the  relevant  intellectual  property  from  third  parties,  which  may  not  be  available  on
reasonable terms or at all.

Any litigation or claim against us, even those without merit, may cause us to incur substantial costs, and could place a significant
strain on our financial resources, divert the attention of management from our core business, negatively impact shareholder value
and harm our reputation.  If we are found to infringe the intellectual property rights of third parties, we could be required to pay
substantial  damages  (which may be increased  up to three  times  of awarded  damages)  and/or substantial  royalties  and could be
prevented from selling our products unless we obtain a license or are able to redesign our products to avoid infringement.  Any
such license may not be available on reasonable terms, if at all, and there can be no assurance that we would be able to redesign
our products in a way that would not infringe the intellectual property rights of others.  If we fail to obtain any required licenses
or make any necessary changes to our products or technologies, we may have to withdraw existing products from the market or
may be unable to commercialize one or more of our products, all of which could have a material adverse effect on our business,
results of operations and financial condition.

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In addition, we generally indemnify our customers with respect to infringement by our products of the proprietary rights of third
parties.  Third parties may assert infringement claims against our customers.  These claims may require us to initiate or defend
protracted and costly litigation on behalf of our customers, regardless of the merits of these claims. If any of these claims succeed,
we may be forced to pay damages on behalf of our customers or may be required to obtain licenses for the products they use.  If
we  cannot  obtain  all  necessary  licenses  on  commercially  reasonable  terms,  our  customers  may  be  forced  to  stop  using  our
products.

We may be subject to damages resulting from claims that we or our employees have wrongfully used or disclosed alleged trade
secrets of our competitors or are in breach of non-competition or non-solicitation agreements with our competitors.

Many  of  our  employees  were  previously  employed  at  other  medical  device  companies,  including  our  competitors  or  potential
competitors, in some cases until recently.  We have been the subject of and may, in the future, be subject to claims that we, our
employees have inadvertently or otherwise used or disclosed alleged trade secrets or other proprietary information of these former
employers or competitors.  In addition, we have been and may in the future be subject to claims that we caused an employee to
breach the terms of his or her non-competition or non-solicitation agreement.  Litigation may be necessary to defend against these
claims.    Even  if  we  are  successful  in  defending  against  these  claims,  litigation  could  result  in  substantial  costs  and  could  be  a
distraction to management.  If our defense to those claims fails, in addition to paying monetary damages, we may lose valuable
intellectual property rights or personnel.  Any litigation or the threat thereof may adversely affect our ability to hire employees.  A
loss of key personnel or their work product could hamper or prevent our ability to commercialize product candidates, which could
have an adverse effect on our business, results of operations and financial condition.

We are and may be subject to warranty or product liability claims or other litigation in the ordinary course of business that
may adversely affect our business, financial condition and operating results.

As a supplier of medical devices, we are and may be subject to warranty or product liability claims alleging that the use of our
products has resulted in adverse health effects or other litigation in the ordinary course of business that may require us to make
significant expenditures to defend these claims or pay damage awards.  The breast implant industry has a particularly significant
history of product liability litigation. The risks of litigation exist even with respect to products that have received or in the future
may receive regulatory approval for commercial sale, such as our Breast Products.  In addition, our silicone gel breast implants
are sold with a warranty providing for no-charge replacement implants in the event of certain ruptures that occur any time during
the life of the patient and this warranty also includes cash payments to offset surgical fees if the rupture occurs within 10 years of
implantation.

We maintain product liability insurance, but this insurance is limited in amount and subject to significant deductibles.  There is no
guarantee that insurance will be available or adequate to protect against all claims.  Our insurance policies are subject to annual
renewal and we may not be able to obtain liability insurance in the future on acceptable terms or at all.  In addition, our insurance
premiums could be subject to increases in the future, which may be material.  If the coverage limits are inadequate to cover our
liabilities or our insurance costs continue to increase as a result of warranty or product liability claims or other litigation, then our
business, financial condition and operating results may be adversely affected.

Fluctuations in insurance cost and availability could adversely affect our profitability or our risk management profile.

We hold a number of insurance policies, including product liability insurance, directors’ and officers’ liability insurance, general
liability insurance, property insurance, employment practices, and workers’ compensation insurance.  If the costs of maintaining
adequate  insurance  coverage  increase  significantly  in  the  future,  our  operating  results  could  be  materially  adversely
affected.    Likewise,  if  any  of  our  current  insurance  coverage  should  become  unavailable  to  us  or  become  economically
impractical, we would be required to operate our business without indemnity from commercial insurance providers.  If we operate
our  business  without  insurance,  we  could  be  responsible  for  paying  claims  or  judgments  against  us  that  would  have  otherwise
been covered by insurance, which could adversely affect our results of operations or financial condition.

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Risks Related to Our Legal and Regulatory Environment

We are subject to extensive federal and state healthcare regulation, and if we fail to comply with applicable regulations, we
could suffer severe criminal or civil sanctions or be required to restructure our operations, any of which could adversely affect
our business, financial condition and operating results.

As  a  device  manufacturer,  even  though  we  do  not  control  referrals  or  bill  directly  to  Medicare,  Medicaid  or  other  third-party
payors,  we  are  subject  to  healthcare  fraud  and  abuse  regulation  and  enforcement  by  the  federal  government  and  the  states  in
which we conduct our business, as well as other healthcare laws and regulations.  The healthcare laws and regulations that may
affect our ability to operate include:

·

·

the  federal  Anti-Kickback  Statute,  which  applies  to  our  business  activities,  including  our  marketing  practices,
educational  programs,  pricing  policies  and  relationships  with  healthcare  providers,  by  prohibiting,  among  other
things, knowingly and willfully soliciting, receiving, offering or providing any remuneration (including any bribe,
kickback or rebate) directly or indirectly, overtly or covertly, in cash or in kind, intended to induce or in return for
the  purchase  or  recommendation  of  any  good,  facility,  item  or  service  reimbursable,  in  whole  or  in  part,  under  a
federal healthcare program, such as the Medicare or Medicaid programs. A person or entity does not need to have
actual knowledge of the federal Anti-Kickback Statute or specific intent to violate it in order to commit a violation.
Rather, if “one purpose” of the remuneration is to induce referrals, the federal Anti-Kickback Statute is violated. In
addition, following passage of the PPACA violations of the federal Anti-Kickback Statute became per se violations
of the False Claims Act;

federal  civil  and  criminal  false  claims  laws  and  civil  monetary  penalty  laws,  including  the  FCA,  that  prohibit,
among other things, knowingly presenting, or causing to be presented, claims for payment from Medicare, Medicaid
or  other  government  payors  that  are  false  or  fraudulent,  or  making  a  false  statement  to  decrease  or  conceal  an
obligation  to  pay  or  transmit  money  or  property  to  the  federal  government,  and  which  may  apply  to  entities  that
provide coding and billing advice to customers;

· HIPAA, and its implementing regulations, which created additional federal criminal laws that prohibit, among other
things,  knowingly  and  willfully  executing,  or  attempting  to  execute  a  scheme  to  defraud  any  healthcare  benefit
program or making false statements relating to healthcare matters;

·

·

·

and,  HIPAA,  as  amended  by  HITECH,  also  imposes  certain  regulatory  and  contractual  requirements  on  certain
types  of  people  and  entities  subject  to  the  law  and  their  business  associates  regarding  the  privacy,  security  and
transmission of individually identifiable health information;

the federal Physician Payments Sunshine Act, enacted under the PPACA, which requires certain manufacturers of
drugs,  devices,  biologics,  and  medical  supplies  for  which  payment  is  available  under  Medicare,  Medicaid,  or  the
Children’s Health Insurance Program, with specific exceptions, to make annual reports to the Centers for Medicare
&  Medicaid  Services,  or  CMS,  regarding  any  “transfers  of  value”  provided  to  physicians  and  teaching  hospitals.
Failure to submit required information may result in civil monetary penalties of up to an aggregate of $150,000 per
year and up to an aggregate of $1 million per year for “knowing failures,” for all payments, transfers of value or
ownership or investment interests that are not timely, accurately, and completely reported in an annual submission.
We are required to report detailed payment data and submit legal attestation to the accuracy of such data by March
31st of each calendar year; and

state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws that may apply
to  items  or  services  reimbursed  by  any  third-party  payor,  including  commercial  insurers;  state  laws  that  require
device  companies  to  comply  with  the  industry’s  voluntary  compliance  guidelines  and  the  relevant  compliance
guidance promulgated by the federal government or otherwise restrict payments that may be provided to healthcare
providers  and  entities;  state  laws  that  require  device  manufacturers  to  report  information  related  to  payments  and
other  transfers  of  value  to  physicians  and  other  healthcare  providers  and  entities  or  marketing  expenditures;  and
state laws governing the privacy and security of certain health information, many of which differ from each other in
significant ways and often are not preempted by HIPAA, thus complicating compliance efforts.

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Because of the breadth of these laws, it is possible that some of our business activities, including our relationships with physicians
and other health care providers and entities, some of whom recommend, purchase and/or prescribe our products, could be subject
to challenge under one or more of such laws.  Any action against us for violation of these laws, even if we successfully defend
against  it,  could  cause  us  to  incur  significant  legal  expenses  and  divert  our  management’s  attention  from  the  operation  of  our
business.  If our operations are found to be in violation of any of the laws described above or any other governmental regulations
that  apply  to  us,  we  may  be  subject  to  penalties,  including,  without  limitation,  administrative,  civil  and/or  criminal  penalties,
damages,  fines,  disgorgement,  contractual  damages,  reputational  harm,  exclusion  from  governmental  health  care  programs,
diminished  profits  and  future  earnings,  additional  reporting  requirements  and  oversight  if  we  become  subject  to  a  corporate
integrity  agreement  or  similar  agreement  to  resolve  allegations  of  non-compliance  with  these  laws,  and  the  curtailment  or
restructuring of our operations, any of which could adversely affect our ability to operate our business and our financial results.

Our medical device  products and operations are subject to extensive governmental regulation both in the United States and
abroad, and our failure to comply with applicable requirements could cause our business to suffer.

Our medical device products and operations are subject to extensive regulation by the FDA and various other federal, state and
foreign  governmental  authorities,  such  as  Health  Canada.    Government  regulation  of  medical  devices  is  meant  to  assure  their
safety and effectiveness, and includes regulation of, among other things:

·

·

·

·

design, development and manufacturing;

testing, labeling, content and language of instructions for use and storage;

clinical trials;

product safety;

· marketing, sales and distribution;

·

·

·

·

·

·

·

·

regulatory clearances and approvals including pre-market clearance and approval;

conformity assessment procedures;

product traceability and record keeping procedures;

advertising and promotion;

product complaints, complaint reporting, recalls and field safety corrective actions;

post-market  surveillance,  including  reporting  of  deaths  or  serious  injuries  and  malfunctions  that,  if  they  were  to
recur, could lead to death or serious injury;

post-market studies; and

product import and export.

The regulations to which we are subject are complex and have tended to become more stringent over time.  Regulatory changes
could  result  in  restrictions  on  our  ability  to  carry  on  or  expand  our  operations,  higher  than  anticipated  costs  or  lower  than
anticipated sales.

Before we can market or sell a new regulated product or a significant modification to an existing product in the United States, we
must obtain either clearance under Section 510(k) of the Federal Food, Drug and Cosmetic Act, or FDCA, or an approval of a
PMA application unless the device is specifically exempt from pre-market review.  In the 510(k) clearance process, the FDA must
determine that a proposed device is “substantially equivalent” to a device legally on the market, known as a “predicate” device,
with  respect  to  intended  use,  technology  and  safety  and  effectiveness,  in  order  to  clear  the  proposed  device  for
marketing.  Clinical data is sometimes required to support substantial equivalence. 

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In the PMA approval process, the FDA must determine that a proposed device is safe and effective for its intended use based, in
part,  on  specific  data,  including,  but  not  limited  to,  pre-clinical,  clinical  trial,  and  other  product  data.    The  PMA  process  is
typically required for devices for which the 510(k) process cannot be used and that are deemed to pose the greatest risk, such as
life-sustaining, life-supporting or implantable devices.  Modifications to products that are approved through a PMA application
generally  need  FDA  approval.    Similarly,  some  modifications  made  to  products  cleared  through  a  510(k)  may  require  a  new
510(k).    The  FDA’s  510(k)  clearance  process  usually  takes  from  three  to  12  months,  but  may  last  longer.    The  process  of
obtaining  a  PMA  is  much  more  costly  and  uncertain  than  the  510(k)  clearance  process  and  generally  takes  from  one  to  three
years, or even longer, from the time the application is submitted to the FDA until an approval is obtained.

In the United States, our silicone gel breast implants are marketed pursuant to a PMA order issued by the FDA in March 2012,
and our tissue expanders are marketed pursuant to pre-market clearance under Section 510(k) of the FDCA.  If the FDA requires
us  to  go  through  a  lengthier,  more  rigorous  examination  for  future  products  or  modifications  to  existing  products  than  we  had
expected, our product introductions or modifications could be delayed or canceled, which could cause our sales to decline.  The
FDA may demand that we obtain a PMA prior to marketing certain of our future products.  In addition, if the FDA disagrees with
our determination that a product we market is subject to an exemption from pre-market review, the FDA may require us to submit
a 510(k) or PMA in order to continue marketing the product.  Further, even with respect to those future products where a PMA is
not required, we cannot assure you that we will be able to obtain the 510(k) clearances with respect to those products.

The FDA can delay, limit or deny clearance or approval of a device for many reasons, including:

· we  may  not  be  able  to  demonstrate  to  the  FDA’s  satisfaction  that  our  products  are  safe  and  effective  for  their

intended uses;

·

·

the data from our pre-clinical studies and clinical trials may be insufficient to support clearance or approval, where
required; and

the manufacturing process or facilities we use may not meet applicable requirements.

In addition, the FDA may change its clearance and approval policies, adopt additional regulations or revise existing regulations,
or take other actions that may prevent or delay approval or clearance of our products under development or impact our ability to
modify  our  currently  approved  or  cleared  products  on  a  timely  basis.  Any  change  in  the  laws  or  regulations  that  govern  the
clearance  and  approval  processes  relating  to  our  current  and  future  products  could  make  it  more  difficult  and  costly  to  obtain
clearance or approval for new products, or to produce, market and distribute existing products.

The FDA could also reclassify some or all of our products that are currently classified as Class II to Class III requiring additional
controls, clinical studies and submission of a PMA for us to continue marketing and selling those products. We cannot guarantee
that the FDA will not reclassify any of our Class II devices into Class III and require us to submit a PMA for FDA review and
approval of the safety and effectiveness of our product. Any delay in, or failure to receive or maintain clearance or approval for
our  products  under  development  could  prevent  us  from  generating  sales  from  these  products  or  achieving  profitability.
Additionally, the FDA and other regulatory authorities have broad enforcement powers.  Regulatory enforcement or inquiries, or
other increased scrutiny on us, could dissuade some surgeons from using our products and adversely affect our reputation and the
perceived safety and efficacy of our products.

In addition, even after we have obtained the proper regulatory clearance or approval to market a product, the FDA has the power
to require us to conduct post-marketing studies.  For example, we are required to continue to study and report clinical results to
the FDA on our silicone gel breast implants.  Failure to conduct this or other required studies in a timely manner could result in
the revocation of the PMA approval or 510(k) clearance for the product that is subject to such a requirement and could also result
in the recall or withdrawal of the product, which would prevent us from generating sales from that product in the United States.

Failure to comply with applicable laws and regulations could jeopardize our ability to sell our products and result in enforcement
actions such as:

· warning letters;

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·

·

·

·

·

·

·

·

fines;

injunctions;

civil penalties;

termination of distribution;

recalls or seizures of products;

delays in the introduction of products into the market;

total or partial suspension of production;

refusal of the FDA or other regulator to grant future clearances or approvals;

· withdrawals  or  suspensions  of  current  clearances  or  approvals,  resulting  in  prohibitions  on  sales  of  our  products;

and/or

·

in the most serious cases, criminal penalties.

Any of these sanctions could result in higher than anticipated costs or lower than anticipated sales and have a material adverse
effect on our reputation, business, results of operations and financial condition.

If  we  or  if  our  third-party  manufacturer  fail  to  comply  with  the  FDA’s  good  manufacturing  practice  regulations,  it  could
impair our ability to market our products in a cost-effective and timely manner.

We and our third-party manufacturers are required to comply with the FDA’s QSR, which covers the methods and documentation
of  the  design,  testing,  production,  control,  quality  assurance,  labeling,  packaging,  sterilization,  storage  and  shipping  of  our
products.  The FDA audits compliance with the QSR through periodic announced and unannounced inspections of manufacturing
and other facilities.  The FDA may conduct inspections or audits at any time.  If we or our manufacturers fail to adhere to QSR
requirements,  have  significant  non-compliance  issues  or  fail  to  timely  and  adequately  respond  to  any  adverse  inspectional
observations  or  product  safety  issues,  or  if  any  corrective  action  plan  that  we  or  our  manufacturers  propose  in  response  to
observed deficiencies is not sufficient, the FDA could take enforcement action against us, which could delay production of our
products and may include:

·

·

·

·

·

untitled letters, warning letters, fines, injunctions, consent decrees and civil penalties;

unanticipated expenditures to address or defend such actions;

customer notifications or repair, replacement, refunds, recall, detention or seizure of our products;

operating restrictions or partial suspension or total shutdown of production;

refusing or delaying our requests for 510(k) clearance or pre-market approval of new products or modified products;

· withdrawing 510(k) clearances or pre-market approvals that have already been granted;

·

·

refusal to grant export approval for our products; or

criminal prosecution.

Any of the foregoing actions could have a material adverse effect on our reputation, business, financial condition and operating
results.  Furthermore, our manufacturer may not currently be or may not continue to be in compliance with

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all  applicable  regulatory  requirements,  which  could  result  in  our  failure  to  produce  our  products  on  a  timely  basis  and  in  the
required quantities, if at all.

There is no guarantee that the FDA will grant 510(k) clearance or PMA approval of our future products, and failure to obtain
necessary clearances or approvals for our future products would adversely affect our ability to grow our business.

Some of our future products may require FDA clearance of a 510(k) or FDA approval of a PMA.  The FDA may not approve or
clear these products for the indications that are necessary or desirable for successful commercialization.  Indeed, the FDA may
refuse our requests for 510(k) clearance or pre-market approval of new products.

Significant delays in receiving clearance or approval, or the failure to receive clearance or approval for our new products would
have an adverse effect on our ability to expand our business.

If  we  modify  our  FDA  approved  or  cleared  devices,  we  may  need  to  seek  additional  clearances  or  approvals,  which,  if  not
granted, would prevent us from selling our modified products.

In the United States, our silicone gel breast implants are marketed pursuant to a PMA order issued by the FDA in March 2012,
and our tissue expanders are marketed pursuant to pre-market clearance under Section 510(k) of the FDCA.  Any modifications to
a PMA-approved or 510(k)-cleared device that could significantly affect its safety or effectiveness, including significant design
and  manufacturing  changes,  or  that  would  constitute  a  major  change  in  its  intended  use,  manufacture,  design,  components,  or
technology  requires  a  new  510(k)  clearance  or,  possibly,  approval  of  a  new  PMA  application  or  PMA  supplement.    However,
certain changes to a PMA-approved device do not require submission and approval of a new PMA or PMA supplement and may
only  require  notice  to  FDA  in  a  PMA  30-Day  Notice,  Special  PMA  Supplement  –  Changes  Being  Effected  or  PMA  Annual
Report.    The  FDA  requires  every  manufacturer  to  make  this  determination  in  the  first  instance,  but  the  FDA  may  review  any
manufacturer’s  decision.    The  FDA  may  not  agree  with  our  decisions  regarding  whether  new  clearances  or  approvals  are
necessary.  We have modified some of our 510(k) cleared products, and have determined based on our review of the applicable
FDA  guidance  that  in  certain  instances  the  changes  did  not  require  new  510(k)  clearances  or  PMA  approvals.    If  the  FDA
disagrees  with  our  determination  and  requires  us  to  seek  new  510(k)  clearances  or  PMA  approvals  for  modifications  to  our
previously cleared or approved products for which we have concluded that new clearances or approvals are unnecessary, we may
be required to cease marketing or to recall the modified product until we obtain clearance or approval, and we may be subject to
significant  regulatory  fines  or  penalties.    Furthermore,  our  products  could  be  subject  to  recall  if  the  FDA  determines,  for  any
reason, that our products are not safe or effective or that appropriate regulatory submissions were not made.  Delays in receipt or
failure to receive approvals, the loss of previously received approvals, or the failure to comply with any other existing or future
regulatory requirements, could reduce our sales, profitability and future growth prospects.

A recall of our products, either voluntarily or at the direction of the FDA or another governmental authority, or the discovery
of serious safety issues with our products that leads to corrective actions, could have a significant adverse impact on us.

The FDA and similar foreign governmental authorities have the authority to require the recall of commercialized products in the
event of material deficiencies or defects in design or manufacture of a product or in the event that a product poses an unacceptable
risk to health.  The FDA’s authority to require a recall must be based on an FDA finding that there is reasonable probability that
the  device  would  cause  serious  injury  or  death.    Manufacturers  may  also,  under  their  own  initiative,  recall  a  product  if  any
material deficiency in a device is found or withdraw a product to improve device performance or for other reasons.  The FDA
requires  that  certain  classifications  of  recalls  be  reported  to  the  FDA  within  10  working  days  after  the  recall  is  initiated.  A
government-mandated or voluntary recall by us or one of our distributors could occur as a result of an unacceptable risk to health,
component  failures,  malfunctions,  manufacturing  errors,  design  or  labeling  defects  or  other  deficiencies  and  issues.    Similar
regulatory agencies in other countries have similar authority to recall devices because of material deficiencies or defects in design
or  manufacture  that  could  endanger  health.    Any  recall  would  divert  management  attention  and  financial  resources  and  could
cause  the  price  of  our  stock  to  decline,  expose  us  to  product  liability  or  other  claims  and  harm  our  reputation  with
customers.  Such events could impair our ability to produce our products in a cost-effective and timely manner in order to meet
our  customers’  demands.    A  recall  involving  our  silicone  gel  breast  implants  could  be  particularly  harmful  to  our  business,
financial and operating results.  Companies are required to maintain certain records of recalls, even if they are not reportable to
the FDA or similar foreign governmental authorities.  We may initiate voluntary recalls involving our products in the future that
we determine do not

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require notification of the FDA or foreign governmental authorities.  If the FDA or foreign governmental authorities disagree with
our  determinations,  they  could  require  us  to  report  those  actions  as  recalls.    A  future  recall  announcement  could  harm  our
reputation with customers and negatively affect our sales.  In addition, the FDA or a foreign governmental authority could take
enforcement action for failing to report the recalls when they were conducted.

In addition, under the FDA’s medical device reporting regulations, we are required to report to the FDA any incident in which our
product may have caused or contributed to a death or serious injury or in which our product malfunctioned and, if the malfunction
were  to  recur,  would  likely  cause  or  contribute  to  death  or  serious  injury.    Repeated  product  malfunctions  may  result  in  a
voluntary or involuntary product recall.  We are also required to follow detailed record-keeping requirements for all firm-initiated
medical  device  corrections  and  removals,  and  to  report  such  corrective  and  removal  actions  to  FDA  if  they  are  carried  out  in
response to a risk to health and have not otherwise been reported under the medical device reporting regulations.  Depending on
the corrective action we take to redress a product’s deficiencies or defects, the FDA may require, or we may decide, that we will
need to obtain new approvals or clearances for the device before we may market or distribute the corrected device.  Seeking such
approvals  or  clearances  may  delay  our  ability  to  replace  the  recalled  devices  in  a  timely  manner.    Moreover,  if  we  do  not
adequately address problems associated with our devices, we may face additional regulatory enforcement action, including FDA
warning letters, product seizure, injunctions, administrative penalties, or civil or criminal fines.  We may also be required to bear
other  costs  or  take  other  actions  that  may  have  a  negative  impact  on  our  sales  as  well  as  face  significant  adverse  publicity  or
regulatory consequences, which could harm our business, including our ability to market our products in the future.

Any  adverse  event  involving  our  products,  whether  in  the  United  States  or  abroad,  could  result  in  future  voluntary  corrective
actions,  such  as  recalls  or  customer  notifications,  or  agency  action,  such  as  inspection,  mandatory  recall  or  other  enforcement
action.    Any  corrective  action,  whether  voluntary  or  involuntary,  as  well  as  defending  ourselves  in  a  lawsuit,  will  require  the
dedication of our time and capital, distract management from operating our business and may harm our reputation and financial
results.

If the third parties on which we rely to conduct our clinical trials and to assist us with pre-clinical development do not perform
as contractually required or expected, we may not be able to obtain regulatory clearance or approval for or commercialize our
products.

We  often  must  rely  on  third  parties,  such  as  contract  research  organizations,  medical  institutions,  clinical  investigators  and
contract laboratories to conduct our clinical trials and preclinical development activities.  If these third parties do not successfully
carry out their contractual duties or regulatory obligations or meet expected deadlines, if these third parties need to be replaced, or
if the quality or accuracy of the data they obtain is compromised due to the failure to adhere to our clinical protocols or regulatory
requirements or for other reasons, our pre-clinical development activities or clinical trials may be extended, delayed, suspended or
terminated, and we may not be able to obtain regulatory clearance or approval for, or successfully commercialize, our products on
a timely basis, if at all, and our business, operating results and prospects may be adversely affected.  Furthermore, our third-party
clinical trial investigators may be delayed in conducting our clinical trials for reasons outside of their control.

We may be subject to regulatory or enforcement actions if we engage in improper marketing or promotion of our products.

Our educational and promotional activities and training methods must comply with FDA and other applicable laws, including the
prohibition of the promotion of a medical device for a use that has not been cleared or approved by the FDA.  Use of a device
outside  of  its  cleared  or  approved  indications  is  known  as  “off-label”  use.    Physicians  may  use  our  products  off-label  in  their
professional medical judgment, as the FDA does not restrict or regulate a physician’s choice of treatment within the practice of
medicine.  However, if the FDA determines that our educational and promotional activities or training constitutes promotion of an
off-label  use,  it  could  request  that  we  modify  our  training  or  promotional  materials  or  subject  us  to  regulatory  or  enforcement
actions, including the issuance of warning letters, untitled letters, fines, penalties, injunctions, or seizures, which could have an
adverse  impact  on  our  reputation  and  financial  results.    It  is  also  possible  that  other  federal,  state  or  foreign  enforcement
authorities may take action if they consider our educational and promotional activities or training methods to constitute promotion
of an off-label use, which could result in significant fines or penalties under other statutory authorities, such as laws prohibiting
false  claims  for  reimbursement.    In  that  event,  our  reputation  could  be  damaged  and  adoption  of  the  products  could  be
impaired.    Although  our  policy  is  to  refrain  from  statements  that  could  be  considered  off-label  promotion  of  our  products,  the
FDA or another regulatory agency could disagree and conclude that we have engaged in off-label promotion.  It is also possible
that other federal, state or foreign enforcemen t  

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authorities might take action, such as federal prosecution under the federal civil False Claims Act, if they consider our business
activities  constitute  promotion  of  an  off-label  use,  which  could  result  in  significant  penalties,  including,  but  not  limited  to,
criminal,  civil  and/or  administrative  penalties,  damages,  fines,  disgorgement,  exclusion  from  participation  in  government
healthcare programs, additional reporting requirements and oversight if we become subject to a corporate integrity agreement or
similar  agreement  to  resolve  allegations  of  non-compliance  with  these  laws,  and  the  curtailment  or  restructuring  of  our
operations.  In addition, the off-label use of our products may increase the risk of product liability claims.  Product liability claims
are expensive to defend and could divert our management’s attention, result in substantial damage awards against us, and harm
our reputation.

Changes in existing third-party coverage and reimbursement may impact our ability to sell our products when used in breast
reconstruction procedures.

Maintaining and growing sales of our products when used in breast reconstruction procedures depends, in part, on the availability
of  coverage  and  adequate  reimbursement  from  third-party  payors,  including  government  programs  such  as  Medicare  and
Medicaid,  private  insurance  plans  and  managed  care  programs.  Breast  augmentation  procedures  are  generally  performed  on  a
cash‑pay  basis  and  are  not  covered  by  third‑party  payors.  In  contrast,  breast  reconstruction  procedures  may  be  covered  by
third‑party  payors.  Therefore,  hospitals  and  other  healthcare  provider  customers  that  purchase  our  products  to  use  in  breast
reconstruction procedures typically bill various third-party payors to cover all or a portion of the costs and fees associated with
the procedures in which our products are used, including the cost of the purchase of our products. Decreases in the amount third-
party payors are willing to reimburse our customers for breast reconstruction procedures using our products could create pricing
pressures for us. The process for determining whether a third-party payor will provide coverage for a product or procedure may
be separate from the process for establishing the reimbursement rate that such a payor will pay for the product or procedure. A
payor’s  decision  to  provide  coverage  for  a  product  or  procedure  does  not  imply  that  an  adequate  reimbursement  rate  will  be
approved. Further, one payor’s determination  to provide coverage for a product or procedure does not assure that other payors
will also provide such coverage. Adequate third-party reimbursement may not be available to enable us to maintain our business
in a profitable way.  We may be unable to sell our products on a profitable basis if third-party payors deny coverage or reduce
their current levels of payment, or if our costs of production increase faster than increases in reimbursement levels.

Furthermore,  the  healthcare  industry  in  the  United  States  has  experienced  a  trend  toward  cost  containment  as  government  and
private  insurers  seek  to  control  healthcare  costs  by  imposing  lower  payment  rates  and  negotiating  reduced  contract  rates  with
service  providers.    Therefore,  we  cannot  be  certain  that  the  breast  reconstruction  procedures  using  our  products  will  be
reimbursed at a cost-effective level.  Nor can we be certain that third-party payors using a methodology that sets amounts based
on the type of procedure performed, such as those utilized by government programs and in many privately managed care systems,
will view the cost of our products to be justified so as to incorporate such costs into the overall cost of the procedure.  Moreover,
we are unable to predict what changes will be made to the reimbursement methodologies used by third-party payors in the future.

To the extent we sell our products internationally, market acceptance may depend, in part, upon the availability of coverage and
reimbursement within prevailing healthcare payment systems.  Reimbursement and healthcare payment systems in international
markets  vary  significantly  by  country,  and  include  both  government-sponsored  healthcare  and  private  insurance.    We  may  not
obtain international coverage and reimbursement approvals in a timely manner, if at all.  Our failure to receive such approvals
would negatively impact market acceptance of our products in the international markets in which those approvals are sought.

Legislative  or  regulatory  health  care  reforms  may  make  it  more  difficult  and  costly  to  produce,  market  and  distribute  our
products after clearance or approval is obtained, or to do so profitably.

Recent  political,  economic  and  regulatory  influences  are  subjecting  the  health  care  industry  to  fundamental  changes.  Both  the
federal  and  state  governments  in  the  United  States  and  foreign  governments  continue  to  propose  and  pass  new  legislation  and
regulations designed to contain or reduce the cost of health care, improve quality of care, and expand access to healthcare, among
other purposes. Such legislation and regulations may result in decreased reimbursement for medical devices and/or the procedures
in  which  they  are  used,  which  may  further  exacerbate  industry-wide  pressure  to  reduce  the  prices  charged  for  medical
devices.  This could harm our ability to market and generate sales from our products.

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In addition, FDA regulations and guidance are often revised or reinterpreted by the FDA in ways that may significantly affect our
business  and  our  products.    Any  new  regulations,  revisions  or  reinterpretations  of  existing  regulations  may  impose  additional
costs or lengthen review times of our products.

Federal  and  state  governments  in  the  United  States  have  recently  enacted  legislation  to  overhaul  the  nation’s  health  care
system.    For  example,  in  March  2010,  the  PPACA  was  signed  into  law.    While  one  goal  of  health  care  reform  is  to  expand
coverage  to  more  individuals,  it  also  involves  increased  government  price  controls,  additional  regulatory  mandates  and  other
measures  designed  to  constrain  medical  costs.    The  PPACA  substantially  changes  the  way  healthcare  is  financed  by  both
governmental  and  private  insurers,  encourages  improvements  in  the  quality  of  healthcare  items  and  services  and  significantly
impacts the medical device industry.  Among other ways in which the PPACA significantly impacts our industry, the PPACA:

·

·

·

·

·

imposes an annual excise tax of 2.3% on any entity that manufactures or imports medical devices offered for sale in
the United States, with limited exceptions;

expands eligibility criteria for Medicaid programs;

establishes  a  new  Patient-Centered  Outcomes  Research  Institute  to  oversee  and  identify  priorities  in  comparative
clinical effectiveness research in an effort to coordinate and develop such research;

implements  payment  system  reforms  including  a  national  pilot  program  on  payment  bundling  to  encourage
hospitals, physicians and other providers to improve the coordination, quality and efficiency of certain health care
services through bundled payment models; and

creates  an  independent  payment  advisory  board  that,  if  impaneled,  will  submit  recommendations  to  Congress  to
reduce Medicare spending if projected Medicare spending exceeds a specified growth rate.

The medical device excise tax has been suspended by the CAA, with respect to medical device sales during calendar years 2016
and 2017.  Absent further Congressional action, this excise tax will be reinstated for medical device sales beginning January 1,
2018.  The CAA also temporarily delays implementation of other taxes intended to help fund PPACA programs.

There have been judicial and Congressional challenges to certain aspects of the PPACA, and we expect there will be additional
challenges and amendments in the future.   In January, Congress voted to adopt a budget resolution for fiscal year 2017, or the
Budget  Resolution,  that  authorizes  the  implementation  of  legislation  that  would  repeal  portions  of  the  PPACA.  The  Budget
Resolution is not a law; however, it is widely viewed as the first step toward the passage of repeal legislation. Further, on January
20, 2017, President Trump signed an Executive  Order directing  federal  agencies  with authorities  and responsibilities  under the
PPACA to waive, defer, grant exemptions from, or delay the implementation of any provision of the PPACA that would impose a
fiscal  or  regulatory  burden  on  states,  individuals,  healthcare  providers,  health  insurers,  or  manufacturers  of  pharmaceuticals  or
medical  devices.  Congress also  could  consider  subsequent  legislation  to  replace  elements  of the PPACA that  are  repealed.  We
cannot predict how the PPACA, its possible repeal, or any legislation that may be proposed to replace the PPACA will impact our
business.

In addition, other legislative changes have been proposed and adopted since the PPACA was enacted.  For example, on August 2,
2011,  the  President  signed  into  law  the  Budget  Control  Act  of  2011,  which,  among  other  things,  created  the  Joint  Select
Committee on Deficit Reduction to recommend to Congress proposals in spending reductions.  The Joint Select Committee did
not  achieve  a  targeted  deficit  reduction  of  at  least  $1.2  trillion  for  the  years  2013  through  2021,  triggering  the  legislation’s
automatic  reduction  to  several  government  programs.    This  includes  reductions  to  Medicare  payments  to  providers  of  2%  per
fiscal  year,  which  went  into  effect  on  April  1,  2013, following  passage  of  the  Bipartisan  Budget  Act  of  2015, and  will  stay  in
effect through 2025 unless additional Congressional action is taken.  Additionally, on January 2, 2013, President Obama signed
into law the ATRA, which, among other things, reduced  Medicare  payments to several  providers, including hospitals, imaging
centers and cancer treatment centers and increased the statute of limitations period for the government to recover overpayments to
providers from three to five years.

In the future there may continue to be additional proposals relating to the reform of the U.S. healthcare system.  Certain of these
proposals could limit the prices we are able to charge for our products or the amount of reimbursement

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available for our products, and could limit the acceptance  and availability of our products, any of which could have a material
adverse effect on our business, results of operations and financial condition.

If we fail to obtain and maintain regulatory approval in Canada, our market opportunities will be reduced.

In order to market our products in Canada, we must obtain and maintain separate regulatory approvals and comply with numerous
and varying regulatory requirements.  We are currently not able to obtain Health Canada’s approval to market our breast implant
products in Canada due to the suspension of Silimed’s ISO 13485 certificate.  Regardless of Silimed’s ISO certification status, the
time required to obtain regulatory approval in Canada may be longer than the time required to obtain FDA pre-market approval
and  Health  Canada  may  want  additional  information  prior  to  approval  as  well.    The  Canadian  regulatory  approval  process
includes many of the risks associated with obtaining FDA approval and we may not obtain Canadian regulatory approval on a
timely basis, if at all.  FDA approval does not ensure approval by regulatory authorities in other countries, including Canada, and
approval  by  one  foreign  regulatory  authority  does  not  ensure  approval  by  regulatory  authorities  in  other  foreign
countries.  However, the failure to obtain clearance or approval in one jurisdiction may have a negative impact on our ability to
obtain clearance or approval elsewhere.  If we do not obtain or maintain necessary approvals to commercialize our products in
Canada, it would negatively affect our overall market penetration.

Our  customers  and  much  of  our  industry  are  required  to  be  compliant  under  the  federal  Health  Insurance  Portability  and
Accountability  Act  of  1996,  the  Health  Information  Technology  for  Economic  and  Clinical  Health  Act  and  implementing
regulations  (including  the  final  Omnibus  Rule  published  on  January  25,  2013)  affecting  the  transmission,  security  and
privacy of health information, and failure to comply could result in significant penalties.

Numerous federal and state laws and regulations, including HIPAA, and HITECH, govern the collection, dissemination, security,
use  and  confidentiality  of  health  information  that  identifies  specific  patients.    HIPAA  and  HITECH  require  our  surgeon  and
hospital customers to comply with certain standards for the use and disclosure of health information within their companies and
with third parties.  The Privacy Standards and Security Standards under HIPAA establish a set of standards for the protection of
individually identifiable health information by health plans, health care clearinghouses and certain health care providers, referred
to  as  Covered  Entities,  and  the  Business  Associates  with  whom  Covered  Entities  enter  into  service  relationships  pursuant  to
which  individually  identifiable  health  information  may  be  exchanged.    Notably,  whereas  HIPAA  previously  directly  regulated
only these Covered Entities, HITECH, which was signed into law as part of the stimulus package in February 2009, makes certain
of HIPAA’s privacy and security standards also directly applicable to Covered Entities’ Business Associates.  As a result, both
Covered Entities and Business Associates are now subject to significant civil and criminal penalties  for failure to comply with
Privacy Standards and Security Standards.

HIPAA requires Covered Entities (like our customers) and Business Associates to develop and maintain policies and procedures
with  respect  to  protected  health  information  that  is  used  or  disclosed,  including  the  adoption  of  administrative,  physical  and
technical  safeguards  to  protect  such  information.    HITECH  expands  the  notification  requirement  for  breaches  of  patient-
identifiable health information, restricts certain disclosures and sales of patient-identifiable health information and provides for
civil  monetary  penalties  for  HIPAA  violations.    HITECH  also  increased  the  civil  and  criminal  penalties  that  may  be  imposed
against Covered Entities and Business Associates and gave state attorneys general new authority to file civil actions for damages
or  injunctions  in  federal  courts  to  enforce  the  federal  HIPAA  laws  and  seek  attorney  fees  and  costs  associated  with  pursuing
federal  civil  actions.    Additionally,  certain  states  have  adopted  comparable  privacy  and  security  laws  and  regulations,  some  of
which may be more stringent than HIPAA.

We  are  not  currently  required  to  comply  with  HIPAA  or  HITECH  because  we  are  neither  a  Covered  Entity  nor  a  Business
Associate  (as  that  term  is  defined  by  HIPAA).    However,  in  administering  our  warranties  and  complying  with  FDA-required
device  tracking,  we  do  regularly  handle  confidential  and  personal  information  similar  to  that  which  these  laws  seek  to
protect.  We also occasionally encounter hospital customers who pressure us to sign Business Associate Agreements, or BAAs,
although, to date, we have refused, given that we do not believe we are business associates to such Covered Entities under HIPAA
or  HITECH.    If  the  law  or  regulations  were  to  change  or  if  we  were  to  agree  to  sign  a  BAA, the  costs  of  complying  with  the
HIPAA standards are burdensome and could have a material adverse effect on our business.  In addition, under such situations
there would be significant risks and financial penalties for us if we were then found to have violated the laws and regulations that
pertain to Covered Entities and Business Associates.

We are unable to predict what changes to the HIPAA Privacy Standards and Security Standards might be made in the future or
how those changes could affect our business.  Any new legislation or regulation in the area of privacy and

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security of personal information, including personal health information, could also adversely affect our business operations.  If we
do not comply with existing or new applicable federal or state laws and regulations related to patient health information, we could
be subject to criminal or civil sanctions and any resulting liability could adversely affect our financial condition.

An  adverse  outcome  of  a  sales  and  use  tax  audit  could  have  a  material  adverse  effect  on  our  results  of  operations  and
financial condition.

We sell our products in all 50 states and each state (and some local governments) has its own sales tax laws and regulations.  We
charge  each  of  our  customers  sales  tax  on  each  order  and  report  and  pay  that  tax  to  the  appropriate  state  authority,  unless  we
believe there is an applicable exception.  In some states, there are no available exceptions; in some states, we believe our products
can  be  sold  tax-free.   In  other  states,  we  believe  we can  sell  our  products  tax-free  only  for  customers  who request  tax-exempt
treatment due to the nature of the devices we sell or due to the nature of the customer’s use of our device.  We may be audited by
the  taxing  authorities  of  one  or  more  states  and  there  can  be  no  assurance,  however,  that  an  audit  will  be  resolved  in  our
favor.  Such an audit could be expensive and time-consuming and result in substantial management distraction.  If the matter were
to  be  resolved  in  a  manner  adverse  to  us,  it  could  have  a  material  adverse  effect  on  our  results  of  operations  and  financial
condition.

Risks Related to Our Common Stock

Our stock price may be volatile, and you may not be able to resell shares of our common stock at or above the price you paid.

The  market  price  of  our  common  stock  is  likely  to  be  highly  volatile  and  could  be  subject  to  wide  fluctuations  in  response  to
various factors, some of which are beyond our control.  For example, our common stock price declined from $20.58 to $2.78 from
September  23,  2015  to  November  17,  2015  primarily  as  a  result  of  the  then-current  events  concerning  Silimed.  These  factors
include those discussed in this “Risk Factors” section of this Form 10-K and others such as:

·

·

·

·

·

·

·

·

·

·

·

·

a determination that our products are not in compliance with regulatory requirements, or our facilities, or those of
our third-party manufacturers are not maintained in compliance with regulatory requirements;

the  timing  and  availability  of  alternative  manufacturing  sources  to  supply  our  silicone  gel  breast  implants,  tissue
expanders and certain other products;

a slowdown in the medical device industry, the aesthetics industry or the general economy;

actual or anticipated quarterly or annual variations in our results of operations or those of our competitors;

changes in accounting principles or changes in interpretations of existing principles, which could affect our financial
results;

actual or anticipated changes in our growth rate relative to our competitors;

changes in earnings estimates or recommendations by securities analysts;

fluctuations in the values of companies perceived by investors to be comparable to us;

announcements  by  us  or  our  competitors  of  new  products  or  services,  significant  contracts,  commercial
relationships, capital commitments or acquisitions;

competition from existing technologies and products or new technologies and products that may emerge;

the entry into, modification or termination of agreements with our sales representatives or distributors;

developments with respect to intellectual property rights;

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·

·

·

·

·

·

sales, or the anticipation of sales, of our common stock by us, our insiders or our other stockholders, including upon
the expiration of contractual lock-up agreements;

our ability to develop and market new and enhanced products on a timely basis;

our ability to integrate and achieve the anticipated benefits of our recent acquisitions of bioCorneum® and the tissue
expanders from SSP;

our commencement of, or involvement in, litigation;

additions or departures of key management or technical personnel; and

changes in laws or governmental regulations applicable to us.

In  recent  years,  the  stock  markets  generally  have  experienced  extreme  price  and  volume  fluctuations  that  have  often  been
unrelated  or  disproportionate  to  the  operating  performance  of  those  companies.    Broad  market  and  industry  factors  may
significantly affect the market price of our common stock, regardless of our actual operating performance.

We do not anticipate  paying any cash dividends  in the foreseeable  future, and accordingly, stockholders  must rely  on stock
appreciation for any return on their investment.

We  do not  anticipate  declaring  any  cash  dividends  to  holders  of  our  common  stock  in  the  foreseeable  future.    In  addition,  our
ability  to  pay  cash  dividends  is  currently  prohibited  by  our  Loan  Agreement.  As  a  result,  capital  appreciation,  if  any,  of  our
common  stock  will  be  your  sole  source  of  gain  for  the  foreseeable  future.    Any  future  determination  to  pay  dividends  will  be
made at the discretion of our board of directors and will depend on then-existing conditions, including our financial condition,
operating results, contractual restrictions,  capital requirements, business prospects and other factors our board of directors may
deem relevant.

Our executive officers, directors and principal stockholders own a significant percentage of our stock and will be able to exert
significant control over matters subject to stockholder approval.

As of March 9, 2017, our executive officers, directors and principal stockholders beneficially  owned approximately 43.52% of
our outstanding voting stock. As a result, these stockholders have the ability to influence us through their ownership position and
may  be  able  to  determine  all  matters  requiring  stockholder  approval.    For  example,  these  stockholders  may  be  able  to  control
elections  of  directors,  amendments  of  our  organizational  documents,  or  approval  of  any  merger,  sale  of  assets,  or  other  major
corporate transaction.  This may prevent or discourage unsolicited acquisition proposals or offers for our common stock that you
may feel are in your best interest as one of our stockholders.

We  are  an  “emerging  growth  company”  and  intend  to  take  advantage  of  reduced  disclosure  requirements  applicable  to
emerging growth companies, which could make our common stock less attractive to investors.

We are an “emerging growth company,” as defined in the JOBS Act, and we intend to take advantage of certain exemptions from
various reporting requirements that apply to other public companies that are not “emerging growth companies.” As an emerging
growth company:

· we are exempt from the requirement to obtain an attestation and report from our auditors on the assessment of our
internal control over financial reporting pursuant to the Sarbanes-Oxley Act of 2002, or the Sarbanes-Oxley Act;

· we  are  permitted  to  provide  less  extensive  disclosure  about  our  executive  compensation  arrangements  in  our

periodic reports, proxy statements and registration statements; and

· we  are  not  required  to  give  our  stockholders  non-binding  advisory  votes  on  executive  compensation  or  golden

parachute arrangements.

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In addition, the JOBS Act provides that an emerging growth company may take advantage of an extended transition period for
complying with new or revised accounting standards.  We have irrevocably elected not to avail ourselves of this exemption and,
therefore, we will be subject to the same new or revised accounting standards as other public companies that are not emerging
growth companies.

We  may  remain  an  emerging  growth  company  until  December  31,  2019  (the  last  day  of  the  fiscal  year  following  the  fifth
anniversary of our initial public offering).  However, if certain events occur prior to the end of such five-year period, including if
we become a “large accelerated filer,” our annual gross revenue equals or exceeds $1.0 billion or we issue more than $1.0 billion
of non-convertible debt in any three-year period, we will cease to be an emerging growth company prior to the end of such five-
year period.

As  a  public  company,  we  are  required  to  assess  our  internal  control  over  financial  reporting  on  an  annual  basis,  and  any
future adverse results from such assessment could result in a loss of investor confidence in our financial reports and have an
adverse effect on our stock price.

As a public company, we are required to comply with certain of the requirements of Section 404 of the Sarbanes-Oxley Act of
2002,  as  amended,  regarding  internal  control  over  financial  reporting,  including  a  report  of  management  on  the  company’s
internal controls over financial reporting in their annual reports on Form 10-K.

In connection with the preparation and audit of our 2016 financial statements, we identified certain deficiencies in our
internal controls over financial reporting that we concluded to be a material weakness and that our internal control over financial
reporting was not effective as of December 31, 2016.  The material weakness resulted from the inadequate design and operation
of internal controls related to the accounting for significant unusual transactions. For more information, see “Item 9.A – Controls
and Procedures – Management Annual Report on Internal Control over Financial Reporting.”

We are in the process of improving policies and procedures and design more effective controls to remediate this material
weakness, but our remediation efforts are not complete and are ongoing. If our remedial measures are insufficient to address the
material weakness, or if additional material weaknesses or significant deficiencies in our internal control are discovered or occur
in the future, it may materially adversely affect our ability to report our financial condition and results of operations in a timely
and accurate manner and impact investor confidence in our Company.

Due to the above referenced material weakness in our internal control over financial reporting, we may be unable to comply with
the SOX 404 internal controls requirements. Additionally, for as long as we remain an “emerging growth company” as defined in
the  JOBS  Act,  we  intend  to  utilize  the  provision  exempting  us  from  the  requirement  that  our  independent  registered  public
accounting  firm  provide  an  attestation  on  the  effectiveness  of  our  internal  control  over  financial  reporting.  The  process  of
becoming fully compliant with Section 404 may divert internal resources and will take a significant amount of time and effort to
complete, and may result in additional deficiencies and material weaknesses being identified by us or our independent registered
public  accounting  firm.  We  may  experience  higher  than  anticipated  operating  expenses,  as  well  as  increased  independent
registered  public  accounting  firm  fees  during  the  implementation  of  any  required  changes  and  thereafter.  Completing
documentation of our internal control system and financial processes, remediation of control deficiencies and management testing
of internal controls will require substantial effort by us. If our internal control over financial reporting or our related disclosure
controls and procedures are not effective, we may not be able to accurately report our financial results or file our periodic reports
in a timely manner, which may cause investors to lose confidence in our reported financial information and may lead to a decline
in our stock price.

Sales of a substantial number of shares of our common stock in the public market could cause our stock price to decline.

Sales of a substantial number of shares of our common stock in the public market could occur at any time.  These sales, or the
perception  in  the  market  that  our  officers,  directors  or  the  holders  of  a  large  number  of  shares  of  common  stock  intend  to  sell
shares, could reduce the market price of our common stock.  As of March 9, 2017, we had approximately 18,833,933 shares of
common stock outstanding. Of these shares, all of the shares of our common stock sold in our initial public offering, which was
completed on November 3, 2014, and all of the shares sold in our follow-on public offering, which was completed on September
23, 2015 are freely tradable, without restriction, in the public market.

Based on shares outstanding as of March 9, 2017, and information contained in Form 4s and Schedule 13Gs filed with the SEC,
up to an additional 4,974,003 shares of common stock became eligible for sale in the public market,

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approximately 44,226 of which are held by our executive officers and directors and approximately 4,929,777 of which are held by
our  affiliates  (including  stockholders  affiliated  with  our  directors)  and  subject  to  volume  limitations  under  Rule  144  under  the
Securities Act.

Holders  of  an  aggregate  of  approximately  5,672,351  shares  of  our  common  stock  have  rights,  subject  to  some  conditions,  to
require us to file registration statements covering their shares or to include their shares in registration statements that we may file
for ourselves or other stockholders.

As  of  March  9,  2017,  options  to  purchase  an  aggregate  of  3,496,266  shares  of  our  common  stock  were  outstanding  under  our
2007 Plan, our 2014 Plan and our Inducement Plan and an additional 701,062 shares of common stock are reserved for issuance
under our 2014 Plan and our Inducement Plan. These shares can be freely sold in the public market upon issuance and once vested
in accordance with Rule 144, including volume restrictions applicable to “control securities” held by our officers and directors.

We cannot predict what effect, if any, sales of our shares in the public market or the availability of shares for sale will have on the
market  price  of  our  common  stock.  Future  sales  of  substantial  amounts  of  our  common  stock  in  the  public  market,  including
shares  issued  upon  exercise  of  outstanding  options  or  warrants,  or  the  perception  that  such  sales  may  occur,  however,  could
adversely affect the market price of our common stock and also could adversely affect our future ability to raise capital through
the sale of our common stock or other equity-related securities of ours at times and prices we believe appropriate.

Future  sales  and  issuances  of  our  common  stock  or  rights  to  purchase  common  stock,  including  pursuant  to  our  equity
incentive plans, could result in additional dilution of the percentage ownership of our stockholders and could cause our stock
price to fall.

We expect that significant additional capital may be needed in the future to continue our planned operations, including conducting
clinical  trials,  commercialization  efforts,  expanded  research  and  development  activities  and  costs  associated  with  operating  a
public  company.  To  raise  capital,  we  may  sell  common  stock,  convertible  securities  or  other  equity  securities  in  one  or  more
transactions at prices and in a manner we determine from time to time. If we sell common stock, convertible securities or other
equity securities, investors may be materially diluted by subsequent sales. Such sales may also result in material dilution to our
existing stockholders, and new investors could gain rights, preferences and privileges senior to the holders of our common stock.

As of December 31, 2016, the number of shares of common stock reserved for issuance under our 2014 plan was 2,045,495. The
number of shares of our common stock reserved for issuance under the 2014 Plan automatically increases on January 1 of each
year, continuing through and including January 1, 2024, by 4% of the total number of shares of our capital stock outstanding on
December 31 of the preceding calendar year, or a lesser number of shares determined by our board of directors. Unless our board
of  directors  elects  not  to  increase  the  number  of  shares  available  for  future  grant  each  year,  our  stockholders  may  experience
additional dilution, which could cause our stock price to fall. Pursuant to the foregoing provision, effective January 1, 2017, our
board  of  directors  increased  the  number  of  shares  of  common  stock  reserved  for  issuance  under  the  2014  Plan  by  4%  of  the
number of shares of our capital stock outstanding on December 31, 2016, or 743,947 shares.

As  of  December  31,  2016,  the  number  of  shares  of  common  stock  reserved  for  issuance  under  our  ESPP  was  584,563.  The
number of shares of our common stock reserved for issuance under the ESPP automatically increases on January 1 of each year,
beginning on January 1, 2015 and continuing through and including January 1, 2024, by 1% of the total number of shares of our
capital stock outstanding on December 31 of the preceding calendar year, or a lesser number of shares determined by our board of
directors.  Unless  our  board  of  directors  elects  not  to  increase  the  number  of  shares  available  for  future  grant  each  year,  our
stockholders may experience additional dilution, which could cause our stock price to fall. Pursuant to the foregoing provision,
effective January 1, 2017, our board of directors increased the number of shares of common stock reserved for issuance under the
ESPP by 1% of the number of shares of our capital stock outstanding on December 31, 2016, or 185,986 shares.

Pursuant to the Inducement Plan that our board of directors approved in March 2016, our compensation committee of the board of
directors  is authorized  to grant  stock  options or  restricted  stock  units  which may  be exercised  or  settled,  as  applicable,  to  new
employees  as  inducements  material  to  such  new  employees  entering  into  employment  with  us  in  accordance  with  NASDAQ
Marketplace Rule 5635(c)(4). Since the inception of the Inducement Plan, options to purchase

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330,000 shares had been awarded by the compensation committee and the number of shares available for future grant was 70,000
shares.  The  number  of  shares  that  may  be  granted  under  the  Inducement  Plan  may  be  increased  in  the  future  by  our  board  of
directors.

Anti-takeover  provisions  in  our  organizational  documents  and  under  Delaware  law  may  discourage  or  prevent  a  change  of
control, even if an acquisition would be beneficial to our stockholders, which could reduce our stock price and prevent our
stockholders from replacing or removing our current management.

Our amended  and restated  certificate  of incorporation  and amended  and restated  bylaws contain  provisions  that  could  delay  or
prevent  a  change  of  control  of  our  company  or  changes  in  our  board  of  directors  that  our  stockholders  might  consider
favorable.  Some of these provisions include:

·

·

·

·

·

·

·

a board of directors divided into three classes serving staggered three-year terms, such that not all members of the
board will be elected at one time;

a prohibition on stockholder action through written consent, which requires that all stockholder actions be taken at a
meeting of our stockholders;

a  requirement  that  special  meetings  of  stockholders  be  called  only  by  the  chairman  of  the  board  of  directors,  the
chief executive officer, or by a majority of the total number of authorized directors;

advance notice requirements for stockholder proposals and nominations for election to our board of directors;

a requirement that no member of our board of directors may be removed from office by our stockholders except for
cause  and,  in  addition  to  any  other  vote  required  by  law,  upon  the  approval  of  not  less  than  two-thirds  of  all
outstanding shares of our voting stock then entitled to vote in the election of directors;

a  requirement  of  approval  of  not  less  than  two-thirds  of  all  outstanding  shares  of  our  voting  stock  to  amend  any
bylaws by stockholder action or to amend specific provisions of our certificate of incorporation; and

the authority of the board of directors to issue preferred stock on terms determined by the board of directors without
stockholder approval and which preferred stock may include rights superior to the rights of the holders of common
stock.

We are subject to the provisions of Section 203 of the General Corporation Law of the State of Delaware, which may prohibit
certain  business  combinations  with  stockholders  owning  15%  or  more  of  our  outstanding  voting  stock.    These  and  other
provisions in our amended and restated certificate of incorporation, amended and restated bylaws and Delaware law could make it
more difficult for stockholders or potential acquirers to obtain control of our board of directors or initiate actions that are opposed
by our then-current board of directors, including a merger, tender offer or proxy contest involving our Company.  Any delay or
prevention of a change of control transaction or changes in our board of directors could cause the market price of our common
stock to decline.

If  securities  or  industry  analysts  issue  an  adverse  or  misleading  opinion  regarding  our  stock,  our  stock  price  and  trading
volume could decline.

The  trading  market  for  our  common  stock  will  be  influenced  by  the  research  and  reports  that  industry  or  securities  analysts
publish about us or our business.  If any of the analysts who cover us issue an adverse or misleading opinion regarding us, our
business model, our intellectual property or our stock performance, or if our clinical trials and operating results fail to meet the
expectations of analysts, our stock price would likely decline.  If one or more of these analysts cease coverage of us, or fail to
publish  reports  on  us  regularly,  we  could  lose  visibility  in  the  financial  markets,  which  in  turn  could  cause  our  stock  price  or
trading volume to decline.

Item 1B.  Unresolved Staff Comment s

Not applicable.

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Item 2.  Propertie s

Our headquarters located in Santa Barbara, California is approximately 20,000 square feet. The term of the lease for our
headquarters  expires  in  February  2020.  We  also  lease  warehouse  spaces  located  in  Santa  Barbara,  California,  which  is
approximately 10,000 square feet. The lease term expires in January 2019. We believe that our existing facilities are adequate for
our  current  needs.  As  additional  space  is  needed  in  the  future,  we  believe  that  suitable  space  will  be  available  in  the  required
locations on commercially reasonable terms.

Item 3.  Legal Proceeding s

From time to time, we are involved in legal proceedings and regulatory proceedings arising out of our operations. We establish
reserves for specific liabilities in connection with legal actions that we deem to be probable and estimable. The ability to predict
the  ultimate  outcome  of  such  matters  involves  judgments,  estimates,  and  inherent  uncertainties.  The  actual  outcome  of  such
matters could differ materially from management’s estimates.

Class Action Shareholder Litigation

On September 25, 2015, a lawsuit styled as a class action of the Company’s stockholders was filed in the United States
District Court for the Central District of California. The lawsuit names the Company and certain of our officers as defendants, or
the Sientra Defendants, and alleges violations of Sections 10(b) and 20(a) of the Exchange Act, in connection with allegedly false
and misleading statements concerning the Company’s business, operations, and prospects.  The plaintiff seeks damages and an
award  of  reasonable  costs  and  expenses,  including  attorneys’  fees.  On  November  24,  2015,  three  stockholders  (or  groups  of
stockholders) filed motions to appoint lead plaintiff(s) and to approve their selection on lead counsel.  On December 10, 2015, the
court  entered  an  order  appointing  lead  plaintiffs  and  approving  their  selection  of  lead  counsel.    On  February  19,  2016,  lead
plaintiffs  filed their consolidated amended  complaint, which added claims  under Sections 11, 12(a)(2)  and 15 of the Securities
Act and named as defendants the underwriters associated with the Company’s follow-on public offering that closed on September
23, 2015, or the Underwriter Defendants. On March 21, 2016, the Sientra Defendants and the Underwriter Defendants each filed a
motion to dismiss, or the Motions to Dismiss, the consolidated amended complaints. On April 20, 2016, lead plaintiffs filed their
opposition to the Motions to Dismiss, and the Sientra Defendants and Underwriter Defendants filed separate replies on May 5,
2016.  On  June  9,  2016,  the  court  granted  in  part  and  denied  in  part  the  Motions  to  Dismiss.    On  July  14,  2016,  the  Sientra
Defendants moved the court to reconsider its June 9, 2016 order and grant the Motions to Dismiss in full. On August 4, 2016, lead
plaintiffs  filed  an  opposition  to  the  motion  for  reconsideration.  On  August  12,  2016,  the  court  denied  the  motion  for
reconsideration, and the Sientra Defendants and the Underwriter Defendants each filed an answer to the consolidated amended
complaint.  

On  October  28,  November  5,  and  November  19,  2015,  three  lawsuits  styled  as  class  actions  of  the  Company’s
stockholders were filed in the Superior Court of California for the County of San Mateo. The lawsuits name the Company, certain
of  our  officers  and  directors,  and  the  underwriters  associated  with  our  follow-on  public  offering  that  closed  on  September  23,
2015  as  defendants.  The  lawsuits  allege  violations  of  Sections  11,  12(a)(2),  and  15  of  the  Securities  Act  in  connection  with
allegedly  false  and  misleading  statements  in  our  offering  documents  associated  with  the  follow-on  offering  concerning  our
business,  operations,  and  prospects.  The  plaintiffs  seek  damages  and  an  award  of  reasonable  costs  and  expenses,  including
attorneys’ fees. On December 4, 2015, defendants removed all three lawsuits to the United States District Court for the Northern
District  of  California.    On  December  15  and  December  16,  2015,  plaintiffs  filed  motions  to  remand  the  lawsuits  back  to  San
Mateo Superior Court, or Motions to Remand.  On January 19, 2016, defendants filed their opposition to the Motions to Remand,
and plaintiffs filed their reply in support of the Motions to Remand on January 26, 2016. 

On May 20, 2016, the United States District Court for the Northern District of California granted plaintiffs’ Motions to Remand,
and the San Mateo Superior Court received the remanded cases on May 27, 2016.  On July 19, 2016, the San Mateo Superior
Court  consolidated  the  three  lawsuits.    On  August  2,  2016,  plaintiffs  filed  their  consolidated  complaint.  On  August  5,  2016,
defendants  filed  a  motion  to  stay  all  proceedings  in  favor  of  the  class  action  filed  in  the  United  States  District  Court  for  the
Central District of California.

On September 13, 2016, the parties to the actions pending in the San Mateo Superior Court and the United States District Court
for  the  Central  District  of  California  signed  a  memorandum  of  understanding  that  sets  forth  the  material  deal  points  of  a
settlement that covers both actions and includes class-wide relief. On September 13, 2016, and September 20, 2016, respectively,
the parties filed notices of settlement in both courts. On September 22, 2016, the United States District

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Court  for  the  Central  District  of  California  stayed  that  action  pending  the  court’s  approval  of  a  settlement.  On  September  23,
2016, the San Mateo Superior Court stayed that action as well as pending the court’s approval of a settlement. 

On  December  20,  2016,  the  plaintiffs  in  the  federal  court  action  filed  a  motion  for  preliminary  approval  of  the  class  action
settlement.  On January 23, 2017, the United States District Court for the Central District of California preliminarily approved the
settlement. A final approval hearing in that court is scheduled for May 22, 2017.  On January 5, 2017, the plaintiffs in the state
court  action  also  filed  a  motion  for  preliminary  approval  of  the  class  action  settlement.    On  February  7,  2017,  the  San  Mateo
Superior Court preliminarily approved the settlement.  A final approval hearing in that court is scheduled for May 31, 2017.  The
settlement is contingent upon final approval by both the San Mateo Superior Court and the United States District Court for the
Central District of California. 

As a result of these developments, we have determined that a probable loss has been incurred and have recognized a net charge to
earnings of approximately $1.6 million within general and administrative expense which is comprised of the loss contingency of
approximately  $10.9  million,  net  of  expected  insurance  proceeds  of  approximately  $9.4  million.  We  have  classified  the  loss
contingency  as  “legal  settlement  payable”  and  the  expected  insurance  proceeds  as  “insurance  recovery  receivable”  on  the
accompanying  balance  sheets.  While  it  is  possible  that  we  may  incur  a  loss  greater  than  the  amounts  recognized  in  the
accompanying financial statements, we are unable to determine a range of possible losses greater than the amount recognized.

Silimed Litigation

On November 6, 2016, Silimed filed a lawsuit in the United States District Court for the Southern District of New York
naming  Sientra  as  the  defendant  and  alleging  breach  of  contract  of  the  Silimed  Agreement,  unfair  competition  and
misappropriation of trade secrets against us.  In its complaint, Silimed alleges that our theft, misuse, and improper disclosure of
Silimed’s  confidential,  proprietary,  and  trade  secret  manufacturing  information  was  done  in  order  for  us  to  develop  our  own
manufacturing capability that we intend to use to manufacture our PMA-approved products.  Silimed is seeking a declaration that
we are in material breach of the Silimed Agreement, a preliminary and permanent injunction to prevent our allegedly wrongful
use  and  disclosure  of  Silimed’s  confidential  and  proprietary  information,  as  well  as  unquantified  compensatory  and  punitive
damages.   On November  15, 2016, Sientra filed  its  answer and counterclaims  for declaratory  judgment in which it denied that
Silimed is entitled to any relief including, among other reasons, because of Silimed’s material breach of the Silimed Agreement
and  Silimed’s  unclean  hands,  and  further  seeks  declaratory  relief  that  Sientra  is  the  owner  of  certain  assets  it  acquired  from
Silimed, Inc. in 2007, that Sientra owns, or is exclusively licensed, to any improvements created since April 2007, that Silimed
lacks any confidential information or proprietary rights under the Silimed Agreement, and that Silimed lacks any relevant trade
secret rights.  On December 9, 2016, Silimed filed a motion to strike the Company’s counterclaims.  Briefing on that motion was
completed on December 30, 2016, and the parties are waiting for a decision from the court.  On February 1, 2017, Sientra filed a
motion to stay Silimed’s breach of contract claim in light of a demand for arbitration filed by Sientra against Silimed on January
20, 2017 concerning Silimed’s material breaches of the Silimed Agreement, and to further dismiss, or alternatively stay, the unfair
competition and misappropriation of trade secrets claims.  Briefing on that motion was completed on February 22, 2017, and the
parties are waiting for a decision from the court.  On February 3, 2017, the court held an initial pre-trial conference and entered a
pre-trial  scheduling  order  which  set  a  final  pre-trial  conference  date  of  August  3,  2018.    We  believe  that  Silimed’s  claims  are
legally and factually unsupported and intend to defend this lawsuit vigorously.

On January 20, 2017, Sientra filed an arbitration demand in the International Center for Dispute Resolution in New York
naming  Silimed  as  the  defendant  and  alleging  material  breach  of  the  Silimed  Agreement,  gross  negligence  and  tortious
interference by Silimed, as well as seeking certain declaratory relief.  Among other things, Sientra alleges that Silimed’s supply
failure constitutes a material breach of the Silimed Agreement, and that such breach was caused by Silimed’s grossly negligent or
other willful conduct related to its regulatory suspensions and the fire at its manufacturing facility.   Silimed filed its answer to
Sientra’s arbitration demand on March 8, 2017.  The parties nominated their party arbitrators on March 13, 2017.

Item 4.  Mine Safety Disclosure s

Not applicable.

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PART I I

Item 5.  Market for Registrant’s Common Equit y, Related Stockholder Matters and Issuer Purchases of Equity Securities

Our common stock has been traded on the NASDAQ Global Select Market under the symbol “SIEN” since our initial
public offering on October 29, 2014. Prior to this time, there was no public market for our common stock. The following table
shows the high and low sale prices per share of our common stock as reported on the NASDAQ Global Select Market for the
periods indicated:

Year ended December 31, 2015

First Quarter
Second Quarter
Third Quarter
Fourth Quarter

Year ended December 31, 2016

First Quarter
Second Quarter
Third Quarter
Fourth Quarter

High

Low

$

$

20.93  
26.67  
25.94  
10.61  

10.45  
8.68  
9.26  
10.22  

$

$

14.02  
15.93  
9.38  
2.78  

5.61  
5.60  
6.57  
6.92  

On March 9, 2017, the last reported sale price for our common stock on the NASDAQ Global Select Market was $9.58

per share.

Stock Performance Graph

The graph set forth below compares the cumulative total stockholder return on our common stock between October 29,
2014 (the date of our initial public offering) and December 31, 2016, with the cumulative total return of (a) the NASDAQ Health
Care  Index  and  (b)  the  NASDAQ  Composite  Index,  over  the  same  period.  This  graph  assumes  the  investment  of  $100  on
October 29, 2014 in our common stock, the NASDAQ Health Care Index and the NASDAQ Composite Index and assumes the
reinvestment of dividends, if any. The graph assumes our closing sales price on October 29, 2014 of $16.75 per share as the initial
value of our common stock and not the initial offering price to the public of $15.00 per share.

The comparisons shown in the graph below are based upon historical data. We caution that the stock price performance
shown in the graph below is not necessarily indicative of, nor is it intended to forecast, the potential future performance of our
common stock. Information used in the graph was obtained from the Nasdaq Stock Market LLC, a financial data provider and a
source believed to be reliable. The Nasdaq Stock Market LLC is not responsible for any errors or omissions in such information.

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CUMULATIVE TOTAL RETURN SUMMARY
December 2016

This performance graph shall not be deemed filed for purposes of Section 18 of the Exchange Act or otherwise subject to
liabilities  under  that  section  and  shall  not  be  deemed  to  be  incorporated  by  reference  into  any  filing  of  Sientra,  Inc.  under  the
Securities Act, except as shall be expressly set forth by specific reference in such filing.

Holders of Record

As  of  March  9,  2017,  there  were  approximately  109  holders  of  record  of  our  common  stock.  The  actual  number  of
stockholders is greater than this number of record holders, and includes stockholders who are beneficial owners, but whose shares
are held in street name by brokers and other nominees. This number of holders of record also does not include stockholders whose
shares may be held in trust by other entities.

Dividends

We have not paid any cash dividends on our common stock since inception and do not anticipate paying cash dividends

in the foreseeable future.

Securities Authorized for Issuance under Equity Compensation Plans

Information about our equity compensation plans is incorporated herein by reference to Item 12 of Part III of this Annual

Report on Form 10‑K.

Use of Proceeds from Public Offering of Common Stock

On  November  3,  2014,  we  closed  the  sale  of  5,750,000  shares  of  common  stock  to  the  public  (inclusive  of  750,000
shares of common stock sold by us pursuant to the full exercise of an overallotment option granted to the underwriters) at a price
of $15.00 per share. The offer and sale of the shares in the IPO was registered under the Securities Act pursuant to registration
statements on Form S‑1 (File No. 333‑198837), which was filed with the SEC, on September 19, 2014 and amended subsequently
and  declared  effective  on  October  28,  2014.  Piper  Jaffray  &  Co.  and  Stifel,  Nicolaus  &  Company,  Incorporated  acted  as
managing  underwriters  of  the  offering.  We  raised  approximately  $77.0  million  in  net  proceeds  after  deducting  underwriting
discounts and commissions of approximately $6.0 million and other offering expenses of

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approximately $3.2 million. None of these expenses consisted of payments made by us to directors, officers or persons owning
10% or more of our common stock or to their associates, or to our affiliates.

On  September  23,  2015,  we  closed  the  sale  of  3,000,000  shares  of  common  stock  in  a  follow-on  public  offering  at  a
price  of  $22.00  per  share.  The  offer  and  sale  of  the  shares  in  the  follow-on  offering  were  registered  under  the  Securities  Act
pursuant to registration statements on Form S-1 (File No. 333-206755), which was filed with the SEC and declared effective on
September 17, 2015. Piper Jaffray & Co. and Stifel, Nicolaus & Company, Incorporated acted as joint book-running managers
and Leerink Partners, LLC and William Blair & Company, LLC acted as co-managers. We raised approximately $61.4 million in
net proceeds after deducting underwriting discounts and commissions of approximately $4.0 million and other offering expenses
of approximately $0.6 million. None of these expenses consisted of payments made by us to directors, officers or persons owning
10% or more of our common stock or to their associates, or to our affiliates.

Upon receipt, the net proceeds from our IPO and our follow-on public offering were held in cash and cash equivalents,
primarily  bank  money  market  accounts.  There  has  been  no  material  change  in  our  planned  use  of  the  net  proceeds  from  the
offering as described in our final prospectus filed with the SEC pursuant to Rule 424(b) under the Securities Act on October 29,
2014, or from our follow-on public offering as described in our final prospectus filed with the SEC pursuant to Rule 424(b) under
the  Securities  Act  on  September  23,  2015.  The  amount  and  timing  of  our  actual  expenditures  depend  on  numerous  factors,
including  the  ongoing  status  of  and  results  from  clinical  trials,  as  well  as  any  unforeseen  cash  needs.  Accordingly,  our
management has broad discretion in the application of the net proceeds. As of December 31, 2016, we have used approximately
$24.5 million of the proceeds to repay outstanding debt, $6.9 million for the acquisition of bioCorneum® and related transaction
costs, $5.0 million for the acquisition of Dermaspan™, Softspan™, and AlloX2® tissue expanders from SSP, and $34.4 million
in working capital and other general corporate purposes . 

Purchases of Equity Securities by the Issuer or Affiliated Purchasers

There were no repurchases of shares of common stock made during the year ended December 31, 2016.

Item 6.  Selected Financial Dat a

The  following  selected  financial  data  should  be  read  in  conjunction  with  “Management’s  Discussion  and  Analysis  of
Financial  Condition  and  Results  of  Operations”,  the  financial  statements  and  related  notes,  and  other  financial  information
included in this Annual Report on Form 10‑K.

We derived the financial data for the years ended December 31, 2016,  2015 and 2014 and as of December 31, 2016 and
2015 from our financial statements, which are included elsewhere in this Annual Report on Form 10‑K. The financial data for the
year ended December 31, 2012 and as of December 31, 2013 are derived from audited financial statements which are not included
in this Form 10-K. Historical results are not necessarily indicative of the results to be expected in future periods.

Year Ended December 31,

2016

2015
(in thousands, except share data)

2014

2013

2012

Statement of operations data
Net sales
Gross profit
Net loss

Net loss per share
Basic and diluted

Weighted average shares

Basic and diluted

  $

20,734   $
13,854  
(40,166) 

38,106   $
27,452  
(41,230) 

44,733   $ 35,171   $ 10,447  
33,233  
8,095  
  (23,433) 
(5,811) 

  26,579  
  (19,125) 

  $

(2.20)  $

(2.61)  $

(2.28)  $ (82.25)  $ (85.01) 

  18,233,177  

  15,770,972  

  2,545,371  

  232,512  

  275,642  

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Balance sheet data
Working capital
Total assets
Long-term debt, excluding current position
Stockholders' equity (deficit)

As of December 31,

2016

2015

2014

2013

(in thousands)

  $ 72,484   $ 118,609   $ 103,151   $
  140,805  
 —  
  118,871  

  114,283  
 —  
83,617  

  139,078  
21,671  
95,639  

24,509  
53,166  
15,092  
  (126,673) 

Item 7.  Management’s Discussion and Analysi s of Financial Condition and Results of Operations

The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our
financial  statements  and  related  notes  appearing  elsewhere  in  this  Annual  Report  on  Form  10‑K.  This  discussion  contains
forward‑looking statements that reflect our plans, estimates and beliefs, and involve risks and uncertainties. Our actual results
and the timing of certain events could differ materially from those anticipated in these forward‑looking statements as a result of
several factors, including those discussed in the section titled “Risk Factors” included under Part I, Item 1A and elsewhere in
this Annual Report. See “Special Note Regarding Forward‑Looking Statements” in this Annual Report.

Overview

We are a medical aesthetics company committed to making a difference in patients’ lives by enhancing their body image, growing
their self‑esteem and restoring their confidence. We were founded to provide greater choices to board‑certified plastic surgeons
and  patients  in  need  of  medical  aesthetics  products.  We  have  developed  a  broad  portfolio  of  products  with  technologically
differentiated characteristics, supported by independent laboratory testing and strong clinical trial outcomes. We sell our breast
implants and breast tissue expanders, or Breast Products, exclusively to board‑certified and board‑admissible plastic surgeons and
tailor our customer service offerings to their specific needs, which we believe helps secure their loyalty and confidence. We have
recently  expanded  our  product  portfolio  through  two  acquisitions.    We  began  selling  bioCorneum®,  an  advanced  silicone  scar
treatment directly to physicians after we acquired bioCorneum® from Enaltus in March 2016.  Additionally, we began selling the
AlloX2®, and Dermaspan™ lines of breast tissue expanders, as well as the Softspan™ line of general tissue expanders, after we
acquired these product lines from SSP in November 2016.

Our primary products are silicone gel breast implants for use in breast augmentation and breast reconstruction procedures, which
we  offer  in  approximately  400  variations  of  shapes,  sizes,  fill  volumes  and  textures.  Our  breast  implants  are  primarily  used  in
elective procedures that are generally performed on a cash‑pay basis. Many of our proprietary breast implants incorporate one or
more technologies that differentiate us from our competitors, including High‑Strength Cohesive silicone gel and shell texturing.
Our  breast  implants  offer  a  desired  balance  between  strength,  shape  retention  and  softness  due  to  the  silicone  shell  and
High‑Strength  Cohesive  silicone  gel  used  in  our  implants.  The  texturing  on  Sientra’s  implant  shell  is  designed  to  reduce  the
incidence of malposition, rotation and capsular contracture.

Our breast implants were approved by the FDA, in 2012, based on data we collected from our ongoing, long‑term clinical trial of
our  breast  implants  in  1,788  women  across  36  investigational  sites  in  the  United  States,  which  included  3,506  implants
(approximately  53%  of  which  were  smooth  and  47%  of  which  were  textured).  Our  clinical  trial  is  the  largest  prospective,
long‑term  safety  and  effectiveness  pivotal  study  of  breast  implants  in  the  United  States  and  includes  the  largest  magnetic
resonance imaging, or MRI, cohort with 571 patients. The MRI cohort is a subset of study patients that underwent regular MRI
screenings in addition to the other aspects of the clinical trial protocol prior to FDA approval. Post-approval, all patients in the
long-term clinical trial are subject to serial MRI screenings as part of the clinical protocol. The clinical data we collected over a
nine‑year follow‑up period demonstrated rupture rates, capsular contracture rates and reoperation rates that were comparable to or
better than those of our competitors, at similar time points. In addition to our pivotal study, our clinical data is supported by our
Continued Access Study of 2,497 women in the United States. We have also commissioned  a number of bench studies run by
independent laboratories that we believe further demonstrate the advantages of our breast implants over those of our competitors.

We sell our Breast Products exclusively to board‑certified and board‑admissible plastic surgeons, as determined by the American
Board of Plastic Surgery, who we refer to as Plastic Surgeons. These surgeons have completed the extensive multi‑year plastic
surgery residency training required by the American Board of Plastic Surgery. While aesthetic

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procedures  are  performed  by  a  wide  range  of  medical  professionals,  including  dermatologists,  otolaryngologists,  obstetricians,
gynecologists,  dentists  and  other  specialists,  the  majority  of  aesthetic  surgical  procedures  are  performed  by  Plastic  Surgeons.
Plastic Surgeons are thought leaders in the medical aesthetics industry. According to the American Board of Plastic Surgery, there
are  approximately  6,500  board‑certified  plastic  surgeons  in  the  United  States.  We  seek  to  provide  Plastic  Surgeons  with
differentiated services, including enhanced customer service offerings, a ten‑year limited warranty that we believe is the best in
the industry based on: providing patients with the largest cash reimbursement for certain out‑of‑pocket costs related to revision
surgeries  in  a  covered  event;  a  lifetime  no‑charge  implant  replacement  program  for  covered  ruptures;  and  our  industry‑first
CapCon Care Program, or C3 Program, through which we offer no‑charge replacement implants to breast augmentation patients
who experience capsular contracture within the first five years after implantation with our smooth or textured breast implants.

Between October 9, 2015 and March 1, 2016, we voluntarily suspended the sale of all Sientra devices manufactured by Silimed
due  to  the  suspension  of  Silimed’s  CE  and  ISO  13485  certifications  by  TÜV  SÜD,  Silimed’s  notified  body  under  EU
regulations.  This was followed by Brazilian regulatory inquiries of Silimed and a suspension by the Brazilian regulatory agency
ANVISA and the Department of the Secretary of State of Rio de Janeiro of the manufacturing and shipment of all medical devices
made  by  Silimed,  and  their  recommendation  that  plastic  surgeons  discontinue  implanting  the  devices  until  further  notice.  See
Note 1(e) to our Financial Statements for more information on the history of these developments with Silimed.  

After ongoing discussions with the FDA and our own review of the matter with the assistance of independent experts in
quality management systems, cGMP, and data-based risk assessment, on March 1, 2016, we lifted the temporary hold on sales
.    We  also  informed  our  Plastic  Surgeons  apprising  them  of  our  controlled  market  re-entry  plan  designed  to  optimize  our
inventory supply , which continues to be limited.  

The events involving Silimed will likely continue to adversely impact our business, in particular due to the limitations on
our existing inventory levels , the uncertainty of our customers’ responsiveness to our controlled market re-entry plan , the fact
that Silimed filed a lawsuit against us alleging, among other things, a material breach of the existing manufacturing contract , and
the fact that the manufacturing contract with Silimed expires on its terms on April 1, 2017.  See “Risk Factors — Risks Relating
to Our Business and Our Industry” for further detail.

In  response  to  these  events  and  anticipated  impacts  on  our  business,  we  have  increasingly  focused  our  efforts  on

securing and qualifying an alternate manufacturing supplier.

On August 9, 2016, we announced our collaboration with Vesta, pursuant to which we are working with Vesta towards
establishing a dedicated contract manufacturing facility for our breast implants. On March 14, 2017, we announced that we had
executed a definitive manufacturing agreement with Vesta for the manufacture and supply of our breast implants.  In addition, on
March  14,  2017,  we  announced  that  we  had  submitted  a  PMA  supplement  to  the  FDA  for  the  manufacturing  of  our  PMA-
approved breast implants by Vesta.

We sell our products in the United States through a direct sales organization, which as of December 31, 2016, consisted

of 43 employees, including 36 sales representatives and 7 sales managers.

Components of Operating Results

Net Sales

We recognize revenue, net of sales discounts and estimated returns, as the customer has a standard six-month window to
return purchased Breast Products . We commenced sales of our breast implants in the United States in the second quarter of 2012
and our Breast Products have historically accounted for substantially all of our net sales. However, sales of our Breast Products
accounted for 79% of our net sales for the year end December 31, 2016, as compared to 98% and 97% of our net sales for the
years ended December 31, 2015 and 2014, respectively. The percentage decrease in sales of Breast Products for the year ended
December 31, 2016 reflects the combined effect of the temporary hold on sales and implanting of Breast Products until March 1,
2016 and the commercial introduction of our scar management products as a result of the acquisition of bioCorneum® on March
9, 2016. Sales of scar management products are included the results of operations from the date of acquisition and accounted for
18% of our net sales for the year ended December 31, 2016.

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We expect that, in the future, our net sales will fluctuate on a quarterly basis due to a variety of factors, including seasonality of
breast  augmentation  procedures.    We  believe  that  breast  implant  sales  are  subject  to  seasonal  fluctuation  due  to  breast
augmentation  patients’  planning  their  surgery  leading  up  to  the  summer  season  and  in  the  period  around  the  winter  holiday
season.

Cost of Goods Sold and Gross Margin

Cost of goods sold consists primarily of costs of finished products purchased from our third‑party manufacturers, reserve

for product warranties and warehouse and other related costs.

With respect to our breast implants, each particular style of implant has a fixed unit cost under the contract with our third-party
manufacturers. Our recently acquired breast tissue expanders are manufactured in the United States under an exclusive contract
with  SiMatrix,  a  subsidiary  of  Vesta.    Under  our  contract  with  SiMatrix,  each  particular  product  has  a  fixed  unit  cost.  Our
bioCorneum®  scar  management  products  are  manufactured  in  the  United  States  under  an  exclusive  contract  with  Formulated
Solutions. Under our contract with Formulated Solutions, each particular product has a fixed unit cost.

In addition to product costs, we provide a commercial warranty on our silicone gel breast implants. The warranty covers device
ruptures in certain circumstances. Estimated warranty costs are recorded at the time of sale. Our warehouse and other related costs
include labor, rent, product shipments from our third-party manufacturers and other related costs.

We  expect  our  overall  gross  margin,  which  is  calculated  as net  sales  less  cost of  goods  sold  for a  given  period  divided  by net
sales, to fluctuate in future periods primarily as a result of quantity of units sold, manufacturing price increases, the changing mix
of products sold with different gross margins, overhead costs and targeted pricing programs.

Sales and Marketing Expenses

Our sales and marketing expenses primarily consist of salaries, bonuses, benefits, incentive compensation and travel for our sales,
marketing  and  customer  support  personnel.  Our  sales  and  marketing  expenses  also  include  expenses  for  trade  shows,  our
no‑charge customer shipping program and no-charge product evaluation units, as well as educational, promotional and marketing
activities, including direct and online marketing. We expect our sales and marketing expenses to fluctuate in future periods as a
result of headcount and timing of our marketing programs.  However, we generally expect these costs will increase in absolute
dollars.

Research and Development Expenses

Our research and development, or R&D, expenses primarily consist of clinical expenses, product development costs, regulatory
expenses, consulting services, outside research activities, quality control and other costs associated with the development of our
products and compliance with Good Clinical Practices, or cGCP, requirements. R&D expenses also include related personnel and
consultant compensation and stock‑based compensation expense. We expense R&D costs as they are incurred.

We  expect  our  R&D  expenses  to  vary  as  different  development  projects  are  initiated,  including  improvements  to  our  existing
products, expansions of our existing product lines, new product acquisitions and our FDA‑required PMA post‑approval studies of
our breast implants. However, we generally expect these costs will increase in absolute terms over time as we continue to expand
our product portfolio and add related personnel.

General and Administrative Expenses

Our  general  and  administrative,  or  G&A,  expenses  primarily  consist  of  salaries,  bonuses,  benefits,  incentive
compensation  and  stock-based  compensation  for  our  executive,  financial,  legal,  business  development  and  administrative
functions.    Other  G&A  expenses  include  outside  legal  counsel  and  litigation  expenses,  independent  auditors  and  other  outside
consultants, corporate insurance, facilities and information technologies expenses. In 2014 and 2015, G&A expenses also include
the federal excise tax on the sale of our medical devices in the United States. In 2016, we did not have expense for the federal
excise tax on the sale of our medical devices, as the tax was suspended for 2016 and 2017.

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We expect future G&A expenses to increase as we continue to build our finance, legal, information technology, human
resources and other general administration resources to continue to advance the commercialization of our products.  In addition,
we  expect  to  continue  to  incur  G&A  expenses  in  connection  with  operating  as  a  public  company,  which  may  increase  further
when  we  are  no  longer  able  to  rely  on  the  “emerging  growth  company”  exemption  we  are  afforded  under  the  Jumpstart  Our
Business Startups Act, or the JOBS Act.  

Other (Expense) Income, net

Other  (expense)  income,  net  primarily  consists  of  interest  income,  interest  expense  and  amortization  of  debt  discount

associated with our term loans and insurance recoveries.

In 2012, the Company filed a claim with the Hartford Insurance Company, or Hartford, for reimbursement of legal costs
incurred in connection with litigation with a competitor that was resolved in 2013. The Company held a D&O insurance policy
with Hartford, and the Company and Hartford settled the matter in May 2014. The Company received settlement payments from
Hartford and recovery of costs associated with the litigation of $0.0 million, $0.0 million, and $2.4 million for the years ended
December 31, 2016, 2015 and 2014, respectively.

Critical Accounting Policies and Significant Judgments and Estimates

Our discussion and analysis of our financial condition and results of operations are based on our financial statements,
which have been prepared in accordance with accounting principles generally accepted in the United States. The preparation of
these  financial  statements  requires  management  to  make  estimates  and  judgments  that  affect  the  reported  amounts  of  assets,
liabilities, net sales and expenses and the disclosure of contingent assets and liabilities in our financial statements. We evaluate
our estimates and judgments on an ongoing basis. We base our estimates on historical experience and on various other factors that
we believe are reasonable under the circumstances, the results of which form the basis for making judgments about our financial
condition  and  results  of  operations  that  are  not  readily  apparent  from  other  sources.  Actual  results  may  differ  from  these
estimates.

While our significant accounting policies are more fully described in Note 2 to our financial statements, we believe that
the  following  accounting  policies  to  be  most  critical  to  the  judgments  and  estimates  used  in  the  preparation  of  our  financial
statements.

Revenue Recognition

We sell our products directly to customers in markets where we have regulatory approval. We offer a six‑month return
policy;  and  we  recognize  revenue,  net  of  sales  discounts  and  returns,  in  accordance  with  the  Financial  Accounting  Standards
Board, or FASB, Accounting Standards Codification 605, Revenue Recognition , or ASC 605. ASC 605 requires that six basic
criteria must be met before revenue can be recognized when a right of return exists:

·

·

·

·

·

·

the seller’s price to the buyer is substantially fixed or determinable at the date of sale;

the buyer has paid the seller, or the buyer is obligated to pay the seller and the obligation is not contingent on resale of
the product;

the buyer’s obligation to the seller would not be changed in the event of theft or physical destruction or damage of the
product;

the buyer acquiring the product for resale has economic substance apart from that provided by the seller;

the seller does not have significant obligations for future performance to directly bring about resale of the product by the
buyer; and

the amount of future returns can be reasonably estimated.

Appropriate reserves are established for anticipated sales returns based on historical experience, recent gross sales and
any  notification  of  pending  returns.  The  Company  recognizes  revenue  when  title  to  the  product  and  risk  of  loss  transfer  to
customers,  provided there  are no remaining  performance  obligations  required  of the Company or any written matters  requiring
customer acceptance. The Company allows for the return of product from customers within six months after the original sale and
records  estimated  sales  returns  as  a  reduction  of  sales  in  the  same  period  revenue  is  recognized.  Sales  return  provisions  are
calculated based upon historical experience with actual returns. Actual sales returns in any future period are inherently uncertain
and thus may differ from the estimates. If actual sales returns differ significantly from the

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estimates,  an  adjustment  to  revenue  in  the  current  or  subsequent  period  would  be  recorded.  The  Company  has  established  an
allowance for sales returns of $3.9 million and $0.7 million as of December 31, 2016 and 2015, respectively, recorded net against
accounts receivable in the balance sheet.

A portion  of the  Company’s revenue  is  generated  from  consigned  inventory  of silicone  gel  breast  implants  and tissue
expanders maintained at doctor, hospital, and clinic locations. The customer is contractually obligated to maintain a specific level
of inventory and to notify the Company upon use. For these products, revenue is recognized at the time the Company is notified
by  the  customer  that  the  product  has  been  implanted.  Notification  is  usually  through  the  replenishing  of  the  inventory  and  the
Company  periodically  reviews  consignment  inventories  to  confirm  accuracy  of  customer  reporting.  FDA  regulations  require
tracking the sales of all breast implants.

Warranty Reserve

We offer a limited warranty and a lifetime product replacement program for our silicone gel breast implants. Under the
limited  warranty  program,  we  will  reimburse  patients  for  certain  out‑of‑pocket  costs  related  to  revision  surgeries  performed
within ten years from the date of implantation in a covered event. Under the lifetime product replacement program, we provide
no‑charge  replacement  breast  implants  under  a  covered  event.  The  programs  are  available  to  all  patients  implanted  with  our
silicone breast implants after April 1, 2012 and are subject to the terms, conditions, claim procedures, limitations and exclusions.
Timely completion of a device tracking and warranty enrollment form by the patient’s Plastic Surgeon is required to activate the
programs and for the patient to be able to receive benefits under either program.

We recorded expense for the accrual of warranties in the amounts of $0.1 million, $0.4 million and $0.5 million, for the
years  ended  December  31,  2016,  2015  and  2014,  respectively.  As  of  December  31,  2016  and  2015,  we  held  total  warranty
liabilities of $1.4 million and $1.3 million, respectively.

Stock‑‑Based Compensation

We recognize stock‑based compensation using a fair‑value based method, for costs related to all employee share‑based
payments, including stock options, restricted stock units,   and the employee stock purchase plan.  Stock-based compensation cost
is measured at the date of grant based on the estimated fair value of the award, net of estimated forfeitures.

We estimate the fair value of our stock‑based awards to employees and directors using the Black‑Scholes option pricing
model. The grant date fair value of a stock‑based award is recognized as an expense over the requisite service period of the award
on  a  straight‑line  basis.  In  addition,  we  use  the  Monte-Carlo  simulation  option-pricing  model  to  determine  the  fair  value  of
market-based awards. The Monte-Carlo simulation option-pricing model uses the same input assumptions as the Black-Scholes
model; however, it also further incorporates into the fair-value determination the possibility that the market condition may not be
satisfied.  Compensation  costs  related  to  these  awards  are  recognized  regardless  of  whether  the  market  condition  is  satisfied,
provided that the requisite service has been provided.

The  Black‑Scholes  and  Monte-Carlo  models  require  inputs  of  subjective  assumptions,  including  the  risk‑free  interest
rate,  expected  dividend  yield,  expected  volatility  and  expected  term,  among  other  inputs.  These  estimates  involve  inherent
uncertainties  and  the  application  of  management’s  judgment.  If  factors  change  and  different  assumptions  are  used,  our
stock‑based compensation expense could be materially different in the future.

We  recorded  total  non‑cash  stock‑based  compensation  expense  of  $3.2  million,  $2.4  million  and  $0.6  million  for  the
years  ended  December  31,  2016,    2015  and  2014,  respectively.  As  of  December  31,  2016,  we  had  total  unrecognized
compensation costs of $4.3 million related to our stock options and employee stock purchase plan. These costs are expected to be
recognized  over  a  weighted  average  period  of  2.74  years.  As  of  December  31,  2016,  we  had  total  unrecognized  compensation
costs of $2.2 million related to restricted stock units, or RSUs. These costs are expected to be recognized over a weighted average
period of 1.86 years.

Warrant Liabilities

We have issued warrants to Oxford Finance, LLC, or Oxford, to purchase shares of common stock in connection with
our  previously  held  term  loan  agreement  with  Oxford.  The  warrants  are  recorded  at  fair  value  using  either  the  Black‑Scholes
option pricing model, other binomial valuation model or lattice model, depending on the characteristics of the warrants at the time
of the valuation. The fair value of these warrants is re‑measured at each financial reporting period

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with any changes in fair value being recognized as a component of other income (expense) in the accompanying statements of
operations. We will continue to re‑measure the warrants to fair value until exercise or expiration of the related warrant. 

As  of  December  31,  2016  and  2015,  the  fair  value  of  our  warrant  liability  was  $0.1  million  and  $0.0  million,
respectively. We recognized an increase of other (income) expense of $39,072 for the change in fair value of warrants during the
year ended December 31, 2016, a decrease of $0.4 million for the year ended December 31, 2015 and an increase of $0.2 million
for the year ended December 31, 2014. 

Acquisitions

We account for acquired business combinations using the acquisition method of accounting, which requires that assets
acquired  and  liabilities  assumed  be  recorded  at  fair  value,  with  limited  exceptions.  Valuations  are  generally  completed  for
business  acquisitions  using  a  discounted  cash  flow  analysis.  The  most  significant  estimates  and  assumptions  inherent  in  a
discounted cash flow analysis include the amount and timing of projected future cash flows, the discount rate used to measure the
risks inherent in the future cash flows, the assessment of the asset’s life cycle, and the competitive and other trends impacting the
asset, including consideration of technical, legal, regulatory, economic and other factors. Each of these factors and assumptions
can  significantly  affect  the  value  of  the  intangible  asset.  The  excess  of  the  fair  value  of  consideration  transferred  over  the  fair
value of the net assets acquired is recorded as goodwill.

We believe the fair values assigned to the assets acquired and liabilities assumed are based on reasonable assumptions.
However, these assumptions may be incomplete or inaccurate, and unanticipated events and circumstances may occur. We will
finalize  these  amounts  as  we  obtain  the  information  necessary  to  complete  the  measurement  processes.  Any  changes  resulting
from  facts  and  circumstances  that  existed  as  of  the  acquisition  dates  may  result  in  adjustments  to  the  provisional  amounts
recognized at the acquisition dates. Any changes resulting from facts and circumstances that existed as of the acquisition dates
may result in adjustments to the provisional amounts recognized at the acquisition dates. These changes could be significant. We
will finalize these amounts no later than one year from the respective acquisition dates.

Determining the useful life of an intangible asset also requires judgment, as different types of intangible assets will have
different useful lives and certain assets may even be considered to have indefinite useful lives. Useful life is the period over which
the  intangible  asset  is  expected  to  contribute  directly  or  indirectly  to  our  future  cash  flows.  We  determine  the  useful  lives  of
intangible assets based on a number of factors, such as legal, regulatory, or contractual provisions that may limit the useful life,
and  the  effects  of  obsolescence,  anticipated  demand,  existence  or  absence  of  competition,  and  other  economic  factors  on
useful life.

Acquisition-related contingent consideration associated with a business combination is initially recognized at fair value
and then remeasured each reporting period, with changes in fair value recorded in general and administrative expense. We use the
Monte-Carlo Simulation model to estimate the fair value of contingent consideration, which requires input assumptions about the
likelihood  of  achieving  specified  milestone  criteria,  projections  of  future  financial  performance,  and  assumed  discount  rates.
Changes  in  the  fair  value  of  the  acquisition-related  contingent  consideration  obligations  result  from  several  factors  including
changes  in  discount  periods  and  rates,  changes  in  the  timing  and  amount  of  revenue  estimates  and  changes  in  probability
assumptions with respect to the likelihood of achieving specified milestone criteria. These estimates involve inherent uncertainties
and  the  application  of  management’s  judgment.  If  factors  change  and  different  assumptions  are  used,  our  stock‑based
compensation expense could be materially different in the future.

Recent Accounting Pronouncements

Please  refer  to  Note  2  in  the  notes  to  our  financial  statements  included  in  this  Annual  Report  on  Form  10-K  for

information on recent accounting pronouncements and the expected impact on our financial statements.

Results of Operations

Comparison of the Years Ended December 31, 2016 and 2015

The following table sets forth our results of operations for the years ended December 31, 2016 and 2015:

Year Ended

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Statement of operations data

Net sales
Cost of goods sold
Gross profit

Operating Expenses

Sales and marketing
Research and development
General and administrative
Goodwill impairment
Total operating expenses
Loss from operations
Other income (expense), net

Interest income
Interest expense
Other (expense) income, net
Total other income (expense), net
Loss before income taxes

Income taxes

Net loss

Net Sales

December 31,

2016

2015

(in thousands)

20,734  $
6,880   
13,854   

20,607   
9,704   
23,577   
 —   
53,888   
(40,034)   

63    
(98)   
(36)   
(71)   
(40,105)  
61   
(40,166)  $

38,106  
10,654  
27,452  

25,762  
7,199  
18,738  
14,278  
65,977  
(38,525) 

32  
(3,097) 
360  
(2,705) 
(41,230) 
 —  
(41,230) 

 $

  $

Net sales decreased $17.4 million, or 45.6%, to $20.7 million for the year ended December 31, 2016, as compared to
$38.1  million  for  the  year  ended  December  31,  2015.  The  decrease  was  a  result  of  both  our  voluntary  hold  on  the  sale  and
implanting of all Sientra devices manufactured by Silimed between October 9, 2015 and March 1, 2016 and our controlled re-
entry to market designed to optimize our supply of Breast Products inventory. The decrease in Breast Product net sales was offset
by  $3.8  million  of  scar  management  product  net  sales  for  the  year  ended  December  31,  2016,  following  the  acquisition  of
bioCorneum® in March 2016.

As  of  December  31,  2016,  our  sales  organization  included  43  employees,  as  compared  to  51  employees  as  of

December 31, 2015.

Cost of Goods Sold and Gross Margin

Cost  of  goods  sold  decreased  $3.8  million,  or  35.4%,  to  $6.9  million  for  the  year  ended  December  31,  2016,  as
compared to $10.7 million for the year ended December 31, 2015.  This decrease was due to a decrease in sales volume driven by
both our voluntary hold on sales from October 9, 2015 to March 1, 2016 and our controlled re-entry into the marketplace, offset
by a decrease to our allowance for sales returns.

The gross margins for the years ended December 31, 2016 and 2015 were 66.8% and 72.0%, respectively. The decrease
for the year ended December 31, 2016 was primarily due to increased inventory write-offs, partially offset by increased sales of
our scar management products, which generally have higher gross margins.  The increase in inventory write-offs resulted from the
timing and recognition of products anticipated to expire prior to being sold and discontinuation of certain product lines. 

Sales and Marketing Expenses

Sales and marketing expenses decreased $5.2 million, or 20.0%, to $20.6 million for the year ended December 31, 2016,
as compared to $25.8 million for the year ended December 31, 2015.  This decrease consisted primarily of a $2.9 million decrease
in  employee–related  costs  as  a  result  of  decreased  headcount  and  a  $2.6  million  decrease  in  marketing  costs  due  to  lower
no‑charge customer shipping costs and less direct marketing activities.

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Research and Development Expenses

R&D expenses increased $2.5 million, or 34.8%, to $9.7 million for the year ended December 31, 2016, as compared to
$7.2  million  for  the  year  ended  December  31,  2015.    This  increase  was  primarily  due  to  a  $2.6  million  increase  in  product
development  costs  and  related  consulting  fees,  a  $0.2  million  increase  of  employee  incentive  compensation,  offset  by  a  $0.4
million decrease in clinical trial expenses.

General and Administrative Expenses

G&A expenses increased $4.8 million, or 25.8%, to $23.6 million for the year ended December 31, 2016, as compared to
$18.7 million for the year ended December 31, 2015.  This increase consisted primarily of a $2.9 million increase in outside legal
counsel  and  litigation  expenses,  a  $1.6  million  probable  loss  incurred  related  to  the  proposed  settlement  of  the  class  action
securities litigation, and a $0.8 million increase in amortization expense related to intangible assets acquired in the current fiscal
year, offset by a $0.8 million decrease in medical device excise tax costs as a result of the suspension of the tax during calendar
years 2016 and 2017.

Goodwill Impairment

There were no goodwill impairment charges for the year ended December 31, 2016. Goodwill impairment charges for the year
ended  December  31  2015  were  $14.3  million.  For  additional  information  on  the  goodwill  impairment  for  the  year  ended
December 31, 2015, see Note 5 to our Financial Statements included herein. 

Other Income (Expense), net

Total other income (expense), net for the year ended December 31, 2016 was primarily associated with interest income
on cash held in a money market account, interest paid on inventory payable and expense recognized for the change in fair value of
warrants. Total other income (expense), net for the year ended December 31, 2015 was primarily associated with interest income
on  cash  held  in  a  money  market  account,  interest  expense  on  our  Oxford  term  loans,  which  were  repaid  in  full  in  the  fourth
quarter of 2015 and income recognized for the change in fair value of warrants.

Income Tax Expense

Income tax expense for the year ended December 31, 2016 was associated with a deferred tax liability associated with indefinite
lived intangibles from acquisitions that cannot offset the deferred tax asset. There was no income tax expense for the year ended
December 31, 2015.

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Comparison of the Years Ended December 31, 2015 and 2014

The following table sets forth our results of operations for the years ended December 31, 2015 and 2014:

Statement of operations data

Net sales
Cost of goods sold
Gross profit

Operating Expenses

Sales and marketing
Research and development
General and administrative
Goodwill impairment
Total operating expenses
Loss from operations
Other income (expense), net

Interest income
Interest expense
Other (expense) income, net
Total other income (expense), net
Loss before income taxes

Income taxes

Net loss

Net Sales

Year Ended
December 31,

2015

2014

(in thousands)

  $

  $

38,106  $
10,654   
27,452   

25,762   
7,199   
18,738   
14,278   
65,977   
(38,525)   

32    
(3,097)   
360   
(2,705)   
(41,230)   
 —   
(41,230)  $

44,733  
11,500  
33,233  

23,599  
4,707  
10,712  
 —  
39,018  
(5,785) 

 —  
(2,172) 
2,146  
(26) 
(5,811) 
 —  
(5,811) 

Net  sales  decreased  $6.6  million,  or  14.8%,  to  $38.1  million  for  the  year  ended  December  31,  2015,  as  compared  to
$44.7 million for the year ended December 31, 2014. This decrease was primarily driven by our voluntary hold on the sale and
implanting of all Sientra devices manufactured by Silimed on October 9, 2015.

As  of  December  31,  2015,  our  sales  organization  included  51  employees,  as  compared  to  46  employees  as  of

December 31, 2014.

Cost of Goods Sold and Gross Margin

Cost  of  goods  sold  decreased  $0.8  million,  or  7.4%,  to  $10.7  million  for  the  year  ended  December  31,  2015,  as
compared to $11.5 million for the year ended December 31, 2014. This decrease was primarily due to a decrease in sales volume
driven by our voluntary hold on sales.

The gross margins for the years ended December 31, 2015 and 2014 were 72.0% and 74.3%, respectively. The decrease
in gross margin was primarily due to an incremental $0.3 million reserve for inventory obsolescence recorded in the third quarter
for product that we estimate to expire prior to being sold, greater fixed overhead as a percentage of net sales, and manufacturing
cost increases.

Sales and Marketing Expenses

Sales and marketing expenses increased $2.2 million, or 9.2%, to $25.8 million for the year ended December 31, 2015,
as  compared  to  $23.6  million  for  the  year  ended  December  31,  2014.  This  was  primarily  due  to  a  $3.2  million  increase  in
employee related expenses for the sales department offset by a $0.9 million decrease in marketing costs.

Research and Development Expenses

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R&D expenses increased $2.5 million, or 52.9%, to $7.2 million for the year ended December 31, 2015, as compared to

$4.7 million for the year ended December 31, 2014. This was primarily due to an increase in product development costs.

General and Administrative Expenses

G&A expenses increased $8.0 million, or 74.9%, to $18.7 million for the year ended December 31, 2015, as compared to
$10.7 million for the year ended December 31, 2014. This increase  was primarily  due to an increase  in expenses that relate  to
operating as a public company, termination benefits for certain former executives, and outside legal counsel costs.

Goodwill Impairment

Goodwill  impairment  charges  for  the  year  ended  December  31,  2015  were  $14.3  million.  There  were  no  goodwill  impairment
charges  for  the  year  ended  December  31,  2014.  For  additional  information  on  these  goodwill  impairments,  see  Note  5  to  our
Financial Statements included herein. 

Other (Expense) Income, net

Total other (expense) income, net for the year ended December 31, 2015 was primarily associated with interest expense
on our term loans of $3.1 million, offset by income recognized for the change in fair value of warrants of $0.4 million. Total other
(expense) income, net for the year ended December 31, 2014 was primarily associated with interest expense on our term loans of
$2.2  million,  offset  by  income  from  settlement  payments  from  Hartford  and  recovery  of  costs  associated  with  the  litigation  of
$2.4 million.

Liquidity and Capital Resources

Since our inception, we have incurred significant net operating losses and anticipate that our losses will continue in the
near  term.    We  expect  our  operating  expenses  will  continue  to  grow  as  we  expand  our  operations.    We  will  need  to  generate
significant  net sales to achieve profitability. To date, we have funded our operations primarily with proceeds from the sales of
preferred stock, borrowings under our term loans, sales of our products since 2012, and the proceeds from the sale of our common
stock in public offerings. As of December 31, 2016, we had no long-term debt.

In November 2014, we completed our IPO of common stock in which we sold 5,750,000 shares at a price of $15.00 per
share  ,  raising  approximately  $77.0  million  in  net  proceeds  after  deducting  underwriting  discounts  and  commissions  of
approximately $6.0 million and offering expenses of approximately $3.2 million.

On September 23, 2015, we completed a  follow-on public offering of common stock in which we sold 3,000,000 shares
at a price of $22.00 per share , raising approximately $61.4 million in net proceeds after deducting underwriting discounts and
commissions of approximately $4.0 million and offering expenses of approximately $0.6 million.

As  of  December  31,  2016,  we  had  $67.2  million  in  cash  and  cash  equivalents.  Our  historical  cash  outflows  have
primarily been associated with research and development activities, especially related to obtaining FDA approval for our breast
implant  portfolio  and  complying  with  the  FDA’s  post-approval  requirements,  activities  relating  to  commercialization  and
increases  in  working  capital,  including  the  purchase  of  inventory  as  well  as  the  expansion  of  our  sales  force  and  marketing
programs. In addition, we have used cash to fund recent acquisitions, including $6.9 million for the acquisition of bioCorneum
from Enaltus, which closed on March 9, 2016 and $5.0 million for the acquisition of assets from SSP, which closed on November
2, 2016. We believe that our available cash on hand will be sufficient to satisfy our liquidity requirements for at least the next 12
months from the date our financial statements are issued.

However, we expect that uncertainty regarding expenses we may continue to incur in connection with establishing new
manufacturing capacity with Vesta or any other third-party manufacturer for our breast implants, and our uncertainty regarding
the amount of additional expenses we may incur in connection with regulatory inquiries, as well as expenses we may incur defen
ding against litigation claims, including the Silimed Litigation, may have a material effect on our future cash outflows and our
liquidity.  As a result,  we may be required  to seek additional  funds in the future  from  public or private  offerings  of our capital
stock, borrowings under term loans or from other sources.

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On March 13, 2017 we entered into a Loan and Security Agreement, or the Loan Agreement, with Silicon Valley Bank,
or SVB. Under the terms of the Loan Agreement, SVB made available to us a revolving line of credit of up to $15.0 million and a
$5.0  million  term  loan.  We  have  not  borrowed  any  amounts  under  the  Loan  Agreement.  For  further  details  on  the  Loan
Agreement, see Item 9B — “Other Information.”

Cash Flows

The  following  table  shows  a  summary  of  our  cash  flows  provided  by  (used  in)  operating,  investing  and  financing

activities for the periods indicated:

Net cash (used in) provided by:

Operating activities
Investing activities
Financing activities

Net change in cash and cash equivalents

Cash (used in) provided by operating activities

Year Ended December 31,

2016

2015

(in thousands)

2014

  $

  $

(34,430)  $
(12,835)   
1,676   
(45,589)  $

(18,184)  $
(1,128)   
35,384   
16,072  $

450  
(439) 
86,996  
87,007  

Net cash used in operating activities was $34.4 million and $18.2 million during the years ended December 31, 2016 and
2015, as compared to net cash provided by operating activities of $0.5 million during the year ended December 31, 2014. The
$16.2 million increase in cash used in operating activities between the years ended December 31, 2016 and 2015 was primarily
associated  with  a  $17.4  million  decrease  in  net  sales,  a  $2.1  million  increase  in  operating  expenses,  excluding  goodwill
impairment for 2015, and an increase in cash outflows from operating assets and liabilities resulting from customer deposits and
timing of accounts payable and accrued liability payments. The $18.6 million increase in cash used in operating activities between
the years ended December 31, 2015 and 2014 was primarily associated with the increase in net loss of $35.4 million, which was
affected by our voluntary hold on the sale and implanting of all Sientra devices manufactured by Silimed since October 9, 2015,
offset by a decrease in cash outflows from operating assets and liabilities resulting from a decrease in inventory purchases and
timing of accounts payable payments.

Cash used in investing activities

Net  cash  used  in  investing  activities  was  $12.8  million,  $1.1  million  and  $0.4  million  during  the  years  ended
December 31, 2016, 2015 and 2014, respectively. The increase in cash used in investing activities of $11.7 million between the
years ended December 31, 2016 and 2015 was primarily due to $6.9 million for the acquisition of bioCorneum® in March 2016
and $5.0 million for the acquisition of the AlloX2® and Dermaspan™ lines of breast tissue expanders, in addition the Softspan™
line  of  general  tissue  expanders  in  November  2016.  The  $0.7  million  increase  in  cash  used  in  investing  activities  between  the
years ended December 31, 2015 and 2014 was due to an increase in property and equipment purchases.

Cash provided by financing activities

Net cash provided  by financing  activities  was $1.7 million  during  the year  ended December  31, 2016 as compared  to
$35.4 million during the year ended December 31, 2015. The decrease in cash provided by financing activities of $33.7 million
between the years ended December 31, 2016 and 2015 was primarily the result of decrease in cash proceeds from the issuance of
our common stock. For the year ended December 31, 2015, we received cash proceeds from the issuance of common stock, net of
underwriters discount in a follow-on offering of $62.0 million, offset by the repayment of long-term debt of $26.6 million. The
decrease  in  cash  provided  by  financing  activities  of  $51.6  million  between  the  years  ended  December  31,  2015  and  2014  was
primarily the result of the decrease in cash proceeds from the issuance of

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our common stock. For the year ended December 31, 2014, we received cash proceeds from the issuance of common stock, net of
the underwriters discount in an IPO of $80.2 million.

Our  liquidity  position  and  capital  requirements  are  subject  to  a  number  of  factors.  For  example,  our  cash  inflow  and

outflow may be impacted by the following:

·

·

·

·

·

·

·

·

·

the timing and availability of alternative manufacturing sources, and costs associated with procuring and qualifying
such manufacturing capacity;

net sales generated by our Breast Products, scar management products, and any other future products that we may
develop and commercialize;

costs associated with expanding our sales force and marketing programs;

cost associated with developing and commercializing our proposed products or technologies;

expenses we incur in connection with potential litigation or governmental investigations;

cost of obtaining and maintaining regulatory clearance or approval for our current or future products;

cost of ongoing compliance with regulatory requirements;

anticipated or unanticipated capital expenditures; and

unanticipated G&A expenses.

Our primary short-term capital needs, which are subject to change, include expenditures related to:

·

·

·

·

·

support of our sales and marketing efforts related to our current and future products;

new product acquisition and development efforts ;  

facilities expansion needs;

investment in inventory required to meet customer demands; and

expenses we incur in connection with defending against litigation, including the Silimed Litigation.

Although we believe the foregoing items reflect our most likely uses of cash in the short-term, we cannot predict with
certainty  all of our particular  short-term  cash  uses or the timing  or amount of cash used.  If cash generated  from operations  is
insufficient to satisfy our working capital and capital expenditure requirements, we may be required to sell additional equity or
debt  securities  or  obtain  credit  facilities.    Additional  capital,  if  needed,  may  not  be  available  on  satisfactory  terms,  if  at
all.  Furthermore, any additional equity financing may be dilutive to stockholders, and debt financing, if available, may include
restrictive covenants.  For a discussion of other factors that may impact our future liquidity and capital funding requirements, see
“Risk Factors — Risks Related to Our Financial Results.”

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Contractual Obligations and Commitments

The following table summarizes our contractual obligations and commitments as of December 31, 2016 (in thousands):

Operating lease obligations
Purchase obligations (1)
Total contractual obligations (2)

Payments Due by Period

Total

  Less than 1 year   1 - 3 years
(in thousands)

  3 - 5 years

  More than
5 years

    $

  $

1,560     $
2,571  
4,131   $

532     $

2,571  
3,103   $

1,028     $
 —  
1,028   $

 —     $
 —  
 —   $

 —
 —
 —

(1) Purchase  obligations  include  the  following:  (i)  accounts  payable  and  (ii)  open  purchase  commitments  with  our  contract

manufacturers. We currently expect to fund these commitments with cash flows from operations and existing cash balances.

(2) This table reflects our contractual obligations as of December 31, 2016 and does not reflect the Loan Agreement with SVB

discussed above, which was entered into on March 13, 2017.

Off‑‑Balance Sheet Arrangements

During the periods presented we did not have, nor do we currently have, any off‑balance sheet arrangements as defined

under SEC rules.

Item 7A.  Quantitative and Qualitative Disclosure s about Market Risks

As of December 31, 2016, we had $67.2 million in cash and cash equivalents. We generally hold our cash in checking
accounts and interest-bearing money market accounts. Our exposure to market risk related to interest rate sensitivity is affected by
changes in the general level of U.S. interest rates. Due to the short-term maturities of our cash equivalents and the low risk profile
of our investments, an immediate 100 basis point change in interest rates would not have a material effect on the fair market value
of our cash equivalents.  

Item 8.  Financial Statements and Supplementary Dat a

The financial statements required to be filed pursuant to this Item 8 are appended to this report beginning on page F‑1.

An index of those financial statements is included in Part IV, Item 15 below.

Item 9.  Changes in and Disagreements with Accountant s on Accounting and Financial Disclosure

None.

Item 9A.  Controls and Procedure s

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our principal executive officer and principal financial officer, has evaluated
the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the period covered by this
Annual Report on Form 10‑K.  The term “disclosure controls and procedures,” as defined in Rules 13a‑15(e) and 15d‑15(e) under
the Exchange Act.  Disclosure controls and procedures  include, without limitation,  controls  and procedures  designed to ensure
that  information  required  to  be  disclosed  by  a  company  in  the  reports  that  it  files  or  submits  under  the  Exchange  Act  is  (i)
recorded, processed, summarized and reported, within the time periods specified in the SEC rules and form; and accumulated and
communicated to the company’s management, including its principal executive and principal financial officers, as appropriate to
allow timely decisions regarding required disclosure.

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Based on this evaluation, the Company’s principal executive officer and principal financial officer have concluded that,
as of December 31, 2016, the Company’s disclosure controls and procedures were not effective as a result of a material weakness
described below in Management’s Annual Report on Internal Control over Financial Reporting.

Management’s Annual Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting as such term is
defined in Exchange Act Rule 13a-15(f).  Internal control over financial reporting is a process designed under the supervision and
with  the  participation  of  our  management,  including  our  principal  executive  officer  and  principal  financial  officer,  to  provide
reasonable  assurance  regarding  the  reliability  of  financial  reporting  and  the  preparation  of  financial  statements  for  external
purposes in accordance with accounting principles generally accepted in the United States of America and includes policies and
procedures that:

• pertain  to  the  maintenance  of  records  that  in  reasonable  detail  accurately  and  fairly  reflect  the  transactions  and

dispositions of the assets of the company;

•  provide  reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit  preparation  of  financial
statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the
company are being made only in accordance with authorizations of management and directors of the company;
and

•  provide  reasonable  assurance  regarding  prevention  or  timely  detection  of  unauthorized  acquisition,  use  or

disposition of the company’s assets that could have a material effect on the financial statements.

Because of inherent  limitations,  internal  control over financial reporting  may not prevent or detect misstatements.   In addition,
projections  of  any  evaluation  of  effectiveness  to  future  periods  are  subject  to  the  risk  that  controls  may  become  inadequate
because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

A material weakness is a deficiency, or combination of deficiencies, in internal control over financial reporting such that there is a
reasonable  possibility  that  a  material  misstatement  of  our  annual  or  interim  consolidated  financial  statements  will  not  be
prevented or detected on a timely basis. 

As of December 31, 2016, our management assessed the effectiveness of our internal control over financial reporting using the
criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission in Internal Control – Integrated
Framework (2013) , or the COSO 2013 Framework. Based on this assessment, management concluded that as of December 31,
2016, our internal control over financial reporting was not effective because of the material weakness described below.

The  Company  did  not  maintain  sufficiently  trained  resources  with  knowledge  of  internal  control  over  financial  reporting  as  it
relates to accounting for significant unusual transactions, including coordination with external service providers. As a result, the
Company  did  not  design  and  implement  effective  management  review  controls  over  business  combinations,  specifically  key
assumptions, financial data and calculations used to measure the fair value of acquired assets and liabilities, including contingent
consideration prepared by its external service provider. 

This  material  weakness  resulted  in  material  misstatements  in  the  current  period  to  intangible  assets,  goodwill  and  contingent
consideration, which were corrected by management prior to the issuance of the Company’s financial statements included herein.
These  deficiencies  represented  a  material  weakness  in  our  internal  control  over  financial  reporting  as  of  December  31,  2016
because there is a reasonable possibility that material misstatements to our consolidated financial statements will not be prevented
or detected on a timely basis.  

This annual report does not include an attestation report of the company’s registered public accounting firm due to the established
rules of the Securities and Exchange Commission.

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Changes in Internal Control over Financial Reporting

Except for the material weakness described herein, there was no change in our internal control over financial reporting
that occurred during the three months ended December 31, 2016 that has materially affected, or is reasonably likely to materially
affect, our internal control over financial reporting.

Remedial Measures

The Company is in the process of improving its policies and procedures relating to the recognition and measurement of
significant  unusual  transactions,  including  those  involving  external  service  providers  and  designing  more  effective  controls  to
remediate the material weakness described above. Management plans to enhance its controls related to non-routine transactions
by  supplementing  with  additional  resources  as  necessary,  enhancing  the  design  and  documentation  of  management  review
controls, and improving the documentation of internal control procedures.

Item 9B.  Other Informatio n

Manufacturing Agreement with Vesta

On March 10, 2017, we entered into a manufacturing agreement with Vesta pursuant to which Vesta shall manufacture
and supply our breast implant products. The term of the manufacturing agreement is five years, subject to customary termination
rights by either party including termination for a material breach of the agreement. The manufacturing agreement also contains
certain provisions regarding the rights and responsibilities of the parties with respect to manufacturing specifications, forecasting
and  ordering,  delivery  arrangements,  payment  terms,  packaging  requirements,  limited  warranties,  confidentiality  and
indemnification, including indemnification by us for a breach of certain representations and warranties related to confidentiality
and intellectual property, the breach of which or the failure to provide such indemnity would qualify as a material breach.

The foregoing description of the manufacturing agreement is not complete and is qualified entirely by reference to the
full text of the agreement, a copy of which will be filed with our Quarterly Report on Form 10-Q for the fiscal quarter ending
March 31, 2017.

PMA Supplement Submission

On March 13, 2017, we submitted a PMA supplement to the FDA for the manufacturing of our PMA-approved breast

implants by Vesta, pursuant to a manufacturing agreement entered into between the parties on March 10, 2017.

Loan and Security Agreement with Silicon Valley Bank

On March 13, 2017, we entered into a Loan Agreement with SVB. Under the terms of the Loan Agreement, SVB made
available to us a revolving line of credit of up to $15.0 million, or the Revolving Line, and a $5.0 million term loan, or the Term
Loan. We have not borrowed any amounts under the Revolving Line or the Term Loan. We intend to use the proceeds from the
Loan Agreement for working capital and other general corporate purposes.  

Any indebtedness under the Term Loan and the Revolving Line bear interest at a floating per annum rate equal to the
prime  rate  as  reported  in  The  Wall  Street  Journal  plus  1.00%,  which  as  of  the  closing  date  is  3.75%.  The  Term  Loan  has  a
scheduled maturity date of March 1, 2020. We must make monthly payments of accrued interest under the Term Loan from the
funding  date  of  the  Term  Loan,  or  the  Funding  Date,  until  April  1,  2018,  followed  by  monthly  installments  of  principal  and
interest through the term loan maturity date. The interest-only period may be extended until April 1, 2019 if we have obtained
FDA certification of the manufacturing facility operated by Vesta by March 31, 2018. We may prepay all, but not less than all, of
the Term Loan prior to its maturity date provided we pay SVB a prepayment charge based on a percentage of the then-outstanding
principal balance which shall be equal to 2% if the prepayment occurs prior to the second anniversary of the Funding Date, and
1%  if  the  prepayment  occurs  thereafter.  Upon  making  the  final  payment  of  the  Term  Loan,  whether  upon  prepayment,
acceleration or at maturity, we are required to pay a 12.5% fee on the original principal amount of the Term Loan.

The amount of loans available to be drawn under the Revolving Line is based on a borrowing base equal to 80% of our
eligible  accounts;  provided that if we maintain  an adjusted quick ratio (as defined  in the Loan Agreement)  of 1.5:1.0 for three
continuous consecutive months, we may access the full Revolving Line. We may make (subject to the applicable

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borrowing base at the time) and repay borrowings from time to time under the Revolving Line until the maturity of the facility on
March 13, 2022. 

The  Loan  Agreement  includes  customary  affirmative  and  restrictive  covenants  and  representations  and  warranties,
including  a  financial  covenant  to  maintain  the  adjusted  quick  ratio  (as  defined  in  the  Loan  Agreement)  of  1.15:1.0  while
borrowings  are  outstanding  and  until  we  have  obtained  FDA  certification  of  the  manufacturing  facility  operated  by  Vesta,  a
covenant against the occurrence of a “change in control,” financial reporting obligations, and certain limitations on indebtedness,
liens, investments,  distributions (including  dividends), collateral,  mergers  or acquisitions, taxes, corporate changes, and deposit
accounts.  The  Loan  Agreement  also  includes  customary  events  of  default,  including  payment  defaults,  breaches  of  covenants
following  any  applicable  cure  period,  the  occurrence  of  any  “material  adverse  change”  as  set  forth  in  the  Loan  Agreement,
penalties or judgements in an amount of at least $1,000,000 rendered against us by any governmental agency and certain events
relating to bankruptcy or insolvency. Upon the occurrence of an event of default, a default interest rate of an additional 5.0% may
be applied to any outstanding principal balances, and SVB may declare all outstanding obligations immediately due and payable
and  take  such  other  actions  as  set  forth  in  the  Loan  Agreement.  Our  obligations  under  the  Loan  Agreement  are  secured  by  a
security interest in substantially all of our assets, other than intellectual property.

In connection with the entry into the Term Loan, we will issue a warrant to SVB, or the Warrant, exercisable for such
number of shares of our common stock as equal to $87,500 divided by a price per share equal to the average closing price of the
Company’s common stock on the NASDAQ Capital Market for the five trading days prior to the Funding Date. The Warrant may
be exercised on a cashless basis, and is immediately  exercisable  from the Funding Date through the earlier  of (i) the five year
anniversary of the Funding Date, and (ii) the consummation of certain acquisition transactions involving the Company as set forth
in the Warrant.

At the closing of the Loan Agreement, SVB earned a commitment fee of $937,500 of which we paid $187,500 on the

closing date and the remainder of which is due and payable by us in increments of $187,500 on each anniversary thereof.

The foregoing descriptions of the Loan Agreement and the Warrant are not complete and are qualified entirely by reference to the
full text of the Loan Agreement and Warrant which will be filed with our Quarterly Report on Form 10-Q for the fiscal quarter
ending March 31, 2017.

Executive Officer Employment Agreement Amendment

On  March  10,  2017  we  amended  our  employment  agreement  with  Charles  Huiner,  our  Chief  Operating  Officer  and
Senior  Vice  President  of  Corporate  Development  &  Strategy,  to  provide  for  the  acceleration  of  his  unvested  equity  awards  in
certain limited situations.

The  foregoing  description  of  the  amendment  to  Mr.  Huiner’s  employment  agreement  is  not  complete  and  is  qualified
entirely by reference to the full text of the amendment, a copy of which is filed herewith as Exhibit 10.17 and incorporated herein
by reference.

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Item 10.  Directors, Executive Officers, and Corporate Governanc e

PART II I

Incorporated by reference from the information in our Proxy Statement for our 2017 Annual Meeting of Stockholders,

which we will file with the SEC within 120 days of the end of the fiscal year to which this Annual Report on Form 10‑K relates.

Item 11.  Executive Compensatio n

Incorporated by reference from the information in our Proxy Statement for our 2017 Annual Meeting of Stockholders,

which we will file with the SEC within 120 days of the end of the fiscal year to which this Annual Report on Form 10‑K relates.

Item 12.  Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

Incorporated by reference from the information in our Proxy Statement for our 2017 Annual Meeting of Stockholders,

which we will file with the SEC within 120 days of the end of the fiscal year to which this Annual Report on Form 10‑K relates.

Item 13.  Certain Relationships and Related Transaction s and Director Independence

Incorporated by reference from the information in our Proxy Statement for our 2017 Annual Meeting of Stockholders,

which we will file with the SEC within 120 days of the end of the fiscal year to which this Annual Report on Form 10‑K relates.

Item 14.  Principal Accountant Fees and Service s

Incorporated by reference from the information in our Proxy Statement for our 2017 Annual Meeting of Stockholders,

which we will file with the SEC within 120 days of the end of the fiscal year to which this Annual Report on Form 10‑K relates.

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PART I V

Item 15.  Exhibits, Financial Statements and Schedule

(a)(1) Financial Statements.

The response to this portion of Item 15 is set forth under Item 8 above.

(a)(2) Financial Statement Schedule.

All  schedules  have  been  omitted  because  they  are  not  required  or  because  the  required  information  is  given  in  the

Financial Statements or Notes thereto.

(a)(3) Exhibits.

See the Exhibit Index immediately following the signature page of this Annual Report on Form 10‑K. The exhibits listed

in the Exhibit Index below are filed or incorporated by reference as part of this Annual Report on Form 10‑K.

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Sientra, Inc.
INDEX TO FINANCIAL STATEMENTS AND FINANCIAL STATEMENT SCHEDULE

Report of Independent Registered Public Accounting Firm  
Balance Sheets  
Statements of Operations  
Statements of Convertible Preferred Stock and Stockholders’ Equity (Deficit)  
Statements of Cash Flows  
Notes to Financial Statements  
Schedule II—Valuation and Qualifying Accounts  

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Report of Independent Registered Public Accounting Fir m

The Board of Directors and Stockholders
Sientra, Inc.:

We have audited the accompanying balance sheets of Sientra, Inc. (the Company) as of December 31, 2016 and 2015,
and the related statements of operations, convertible preferred stock and stockholders’ equity (deficit), and cash flows for each of
the years in the three‑year period ended December 31, 2016. In connection with our audits of the financial statements, we also
have  audited  the  related  financial  statement  schedule  II  –  valuation  and  qualifying  accounts.  These  financial  statements  and
financial statement schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on
these financial statements and financial statement schedule based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United
States).  Those standards  require  that we plan  and perform  the  audit  to obtain  reasonable  assurance  about whether  the financial
statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates
made  by  management,  as  well  as  evaluating  the  overall  financial  statement  presentation.  We  believe  that  our  audits  provide  a
reasonable basis for our opinion.

In our opinion, the financial statements and financial statement schedule referred to above present fairly, in all material
respects, the financial position of Sientra, Inc. as of December 31, 2016 and 2015, and the results of its operations and its cash
flows  for  each  of  the  years  in  the  three‑year  period  ended  December  31,  2016,  in  conformity  with  U.S.  generally  accepted
accounting principles.

Los Angeles, California 
March 14, 2017

(signed) KPMG LLP

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Sientra, Inc.

Balance Sheets

(in thousands, except per share data)

Assets
Current assets:

Cash and cash equivalents
Accounts receivable, net of allowances of $4,329 and $1,116 at December 31, 2016 and
December 31, 2015, respectively
Inventories, net
Insurance recovery receivable
Prepaid expenses and other current assets

Total current assets
Property and equipment, net
Goodwill
Other intangible assets, net
Other assets

Total assets

Liabilities and Stockholders’ Equity
Current liabilities:

Accounts payable
Accrued and other current liabilities
Legal settlement payable
Customer deposits

Total current liabilities

Warranty reserve and other long-term liabilities

Total liabilities

Commitments and contingencies (Note 9)
Stockholders’ equity:

December 31,

2016

2015

  $

67,212   $

112,801  

3,082  
18,484  
9,375  
1,852  
100,005  
2,986  
4,878  
6,186  
228  
114,283   $

3,555   $
6,507  
10,900  
6,559  
27,521  
3,145  
30,666  

4,249  
20,602  
 —  
1,473  
139,125  
1,404  
 —  
53  
223  
140,805  

4,069  
6,959  
 —  
9,488  
20,516  
1,418  
21,934  

  $

  $

Preferred stock, $0.01 par value – Authorized 10,000,000 shares; none issued or
outstanding
Common stock, $0.01 par value — Authorized 200,000,000 shares; issued 18,671,409 and
18,066,143 and outstanding 18,598,682 and 17,993,416 shares at December 31, 2016 and
December 31, 2015 respectively
Additional paid-in capital
Treasury stock, at cost (72,727 shares at December 31, 2016 and December 31, 2015)
Accumulated deficit

Total stockholders’ equity
Total liabilities and stockholders’  equity

 —  

 —  

186  
299,133  
(260) 
(215,442) 
83,617  
114,283   $

180  
294,227  
(260) 
(175,276) 
118,871  
140,805  

  $

See accompanying notes to financial statements.

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Net sales
Cost of goods sold
Gross profit

Operating expenses:

Sales and marketing
Research and development
General and administrative
Goodwill impairment

Total operating expenses
Loss from operations

Other income (expense), net:

Interest income
Interest expense
Other (expense) income, net

Total other income (expense), net
Loss before income taxes

Income taxes
Net loss

Sientra, Inc.

Statements of Operations

(in thousands, except per share data)

2016

Year Ended December 31,
2015

2014

 $

20,734   $
6,880  
13,854  

38,106   $
10,654  
27,452  

20,607  
9,704  
23,577  
 —  
53,888  
(40,034) 

63  
(98) 
(36) 
(71) 
(40,105) 
61  
(40,166)  $

25,762  
7,199  
18,738  
14,278  
65,977  
(38,525) 

32  
(3,097) 
360  
(2,705) 
(41,230) 
 —  
(41,230)  $

44,733  
11,500  
33,233  

23,599  
4,707  
10,712  
 —  
39,018  
(5,785)  

 —  
(2,172)  
2,146  
(26)  
(5,811)  
 —  
(5,811)  

 $

 $

(2.20)  $

(2.61)  $

(2.28)  

Basic and diluted net loss per share attributable to common
stockholders
Weighted average outstanding common shares used for net loss per
share attributable to common stockholders:

Basic and diluted

18,233,177  

15,770,972  

2,545,371  

See accompanying notes to financial statements.

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Sientra, Inc.

Statements of Convertible Preferred Stock and Stockholders’ Equity (Deficit )

(in thousands, except per share data)

Convertible preferred
stock

Common stock

Treasury stock

Additional
paid-in

  Accumulated

Shares

Amount  

Shares

Amount 

Shares  

Amount 

capital

deficit

Total
stockholders’  
equity
(deficit)

Balances at
December 31,
2013

Conversion
of
convertible
preferred
stock to
common
stock
Proceeds
from IPO, net
of costs
Stock option
exercises
Employee
stock-based
compensation
expense

Net loss
Balances at
December 31,
2014

Proceeds
from follow-
on offering,
net of costs
Employee
stock-based
compensation
expense
Stock option
exercises
Employee
stock
purchase
program
(ESPP)

Net loss
Balances at
December 31,
2015

Employee
stock-based
compensation
expense
Stock option
exercises
Employee
stock
purchase
program
(ESPP)
Vested
restricted
stock

Net loss

Balances as of
December 31,
2016

24,593,087  

$

150,456  

279,879  

$

3  

72,727  

$

(260) 

1,819  

$

(128,235) 

$

(24,593,087) 

(150,456) 

8,942,925  

89  

 —  

 —  

150,367  

 —

 —

 —

 —

 —

 —

 —

 —

  5,750,000

12,900

 —

 —

58

 —

 —

 —

 —

 —

 —

 —

 —

 —

 —

 —

  76,977

38

594

 —

 —  

 —

 —

 —

(5,811)

 —  

$

 —  

14,985,704  

$

150  

72,727  

$

(260) 

229,795  

$

(134,046) 

$

 —  

 —  

 —

 —

 —

 —  

 —

 —

 —

 —  

3,000,000  

30  

 —  

 —  

61,367  

 —  

 —

 —

 —

 —  

36,189

44,250

 —

 —  

 —

 —

 —

 —  

 —

 —

 —

 —  

 —

 —

 —

 —  

 —  

 —

2,382  

119

564

 —

 —

(41,230)

 —  

$

 —  

18,066,143  

$

180  

72,727  

$

(260) 

$

294,227  

$

(175,276) 

$

 —  

 —

478,099

 —  

 —  

 —

122,667

 —

4,500

 —

 —  

 —

 —

 —

 —

 —  

 —

 —

 —

 —

3,236  

918

752

 —

 —

 —  

 —

 —

 —

(40,166)

5

1

 —

 —

 —  

$

 —  

18,671,409  

$

186  

72,727  

$

(260) 

$

299,133  

$

(215,442) 

$

See accompanying notes to financial statements.

77

(126,673) 

150,456  

  77,035  
38  

594  
(5,811) 

95,639  

61,397  

2,382  
119  

564  
(41,230) 

118,871  

3,236  
923  

753  

 —  
(40,166) 

83,617  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Sientra, Inc.

Statements of Cash Flow s

(in thousands)

Cash flows from operating activities:

Net loss
Adjustments to reconcile net loss to net cash used in operating activities:  

  $

2016

Year Ended December 31,
2015

2014

(40,166)  $

(41,230)  $

(5,811) 

Goodwill impairment
Depreciation and amortization
Provision for doubtful accounts
Provision for warranties
Provision for inventory
Change in fair value of warrants
Change in fair value of contingent consideration
Non-cash interest expense
Stock-based compensation expense
Loss on disposal of property and equipment
Deferred income taxes
Changes in assets and liabilities:

Accounts receivable
Prepaid expenses, other current assets and other assets
Inventories
Insurance recovery receivable
Accounts payable
Accrued and other liabilities
Legal settlement payable
Customer deposits

Net cash (used in) provided by operating activities

Cash flows from investing activities:

Purchase of property and equipment
Business acquisitions

Net cash used in investing activities

Cash flows from financing activities:

Proceeds from exercise of stock options
Proceeds from issuance of common stock, net of underwriters discount
Proceeds from issuance of common stock under ESPP
Deferred equity issuance costs, IPO
Deferred equity issuance costs, follow-on offering
Proceeds from issuance of long-term debt
Repayment of long-term debt
Deferred financing costs

Net cash provided by financing activities
Net (decrease) increase in cash and cash equivalents

Cash and cash equivalents at:

Beginning of period
End of period

Supplemental disclosure of cash flow information:

Interest paid

Supplemental disclosure of non-cash investing and financing activities:

Accrued equity issuance costs
Property and equipment in accounts payable and accrued liabilities
Acquisition of business, deferred and contingent consideration
obligations at fair value

  $

  $

 —  
1,177  
437  
71  
1,384  
39  
37  
3  
3,236  
124  
61  

927  
(529) 
2,390  
(9,375) 
(564) 
(1,422) 
10,900  
(3,160) 
(34,430) 

(1,126) 
(11,709) 
(12,835) 

923  
 —  
753  
 —  
 —  
 —  
 —  
 —  
1,676  
(45,589) 

14,278  
318  
233  
385  
469  
(360) 
 —  
1,386  
2,382  
 —  
 —  

715  
147  
(898) 
 —  
1,546  
1,571  
 —  
874  
(18,184) 

(1,128) 
 —  
(1,128) 

119  
62,040  
564  
(71) 
(643) 
 —  
(26,625) 
 —  
35,384  
16,072  

112,801  
67,212   $

96,729  
112,801   $

 —  
275  
39  
447  
 —  
220  
 —  
490  
594  
 —  
 —  

875  
(864) 
1,359  
 —  
(2,266) 
1,385  
 —  
3,707  
450  

(439) 
 —  
(439) 

38  
80,213  
 —  
(3,107) 
 —  
10,000  
 —  
(148) 
86,996  
87,007  

9,722  
96,729  

96   $

1,884   $

1,577  

 —  
939  

1,600  

 —  
22  

 —  

71  
44  

 —  

See accompanying notes to financial statements.

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Table of Contents

1) Formation and Business of the Company

(a)

Formation

Sientra, Inc.

Notes to Financial Statements

Sientra,  Inc.,  or  the  Company,  was  incorporated  in  the  State  of  Delaware  on  August  29,  2003  under  the  name  Juliet
Medical, Inc. and subsequently changed its name to Sientra, Inc. in April 2007. The Company acquired substantially all the assets
of Silimed, Inc. on April 4, 2007. The purpose of the acquisition was to acquire the rights to the silicone breast implant clinical
trials, related product specifications and pre-market approval, or PMA, assets. Following this acquisition, the Company focused
on completing the clinical trials to gain FDA approval to offer its silicone gel breast implants in the United States.

In  March  2012,  Sientra  announced  it  had  received  approval  from  the  FDA  for  its  portfolio  of  silicone  gel  breast
implants, and in the second quarter of 2012 the Company began commercialization efforts to sell its products in the United States.
The Company, based in Santa Barbara, California, is a medical aesthetics company that focuses on serving board-certified plastic
surgeons  and  offers  a  portfolio  of  silicone  shaped  and  round  breast  implants,  scar  management,  tissue  expanders,  and  body
contouring products.

(b)

Reverse Stock Split

On  October  10,  2014,  the  board  of  directors  and  stockholders  approved  an  amendment  to  the  Company’s  fourth  amended  and
restated certificate of incorporation, which was filed on October 17, 2014, which effected a 2.75-to-1 reverse stock split of the
Company’s issued and outstanding shares of common stock. The par value of the common stock was not adjusted as a result of
the reverse stock split. All issued and outstanding shares of common stock, stock options and warrants and the related per share
amounts contained in the Company’s financial statements have been retroactively adjusted to reflect this reverse stock split for all
periods presented. Also, as a result of the reverse stock split of the common stock, the conversion ratios for all of the Company’s
convertible preferred stock have been adjusted such that the preferred stock are now convertible into shares of common stock at a
conversion rate of 2.75-to-1 instead of 1-to-1. The number of issued and outstanding shares of preferred stock and their related
per  share  amounts  have  not  been  affected  by  the  reverse  stock  split  and  therefore  have  not  been  adjusted  in  the  Company’s
financial  statements.  However,  to  the  extent  that  the  convertible  preferred  stock  are  presented  on  an  as  converted  to  common
stock basis, such share and per share amounts contained in the Company’s financial statements have been retroactively adjusted
to reflect this reverse stock split for all periods presented.

(c)

Initial Public Offering

On November 3, 2014, the Company completed an initial public offering, or IPO, whereby it sold a total of 5,750,000
shares of common stock at $15.00 per share inclusive of 750,000 shares sold to underwriters for the exercise of their option to
purchase additional shares.  The Company received net proceeds from the IPO of approximately $77.0 million, after deducting
underwriting  discounts  and  commissions  and  offering  expenses  of  approximately  $9.2  million.    These  expenses  were  recorded
against the proceeds received from the IPO.  Common stock is listed on the Nasdaq Stock Exchange under the symbol “SIEN.”

The outstanding shares of convertible preferred stock were converted on a 2.75-to-1 basis into shares of common stock
concurrent with the closing of the IPO. All of the outstanding shares of Series A, Series B and Series C preferred stock converted
into 8,942,925 shares of common stock. Following the closing of the IPO, there were no shares of preferred stock outstanding.

(d)

Follow-on Offering

On  September  23,  2015,  the  Company  closed  a  follow-on  public  offering,  whereby  it  sold  3,000,000  shares  of  its
common stock, at a price to the public of $22.00 per share. The Company received net proceeds from the follow-on offering of
approximately $61.4 million, after deducting underwriting discounts and commissions of $4.0 million and offering expenses of
approximately $0.6 million.

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(e)

Regulatory Inquiries Regarding Products Manufactured by Silimed

There  have  been  recent  regulatory  inquiries  related  to  medical  devices  manufactured  by  Silimed  Indústria  de
Implantes  Ltda.  (formerly,  Silimed-Silicone  e  Instrumental  Medico-Cirugio  e  Hospitalar  Ltda.),  or  Silimed,  the  Company’s
former sole source contract manufacturer for its silicone gel breast implants and certain other products.

On September 23, 2015, the Medicines and Healthcare Products Regulatory Agency, or MHRA, an executive agency of
the United Kingdom, or U.K., issued a press release announcing the suspension of sales and implanting in the U.K. of all medical
devices manufactured by Silimed following the suspension of the CE and ISO 13485 certifications  of these products issued by
TÜV SÜD, Silimed’s notified body under European Union, or EU, regulation. The suspension of Silimed’s CE and ISO 13485
certifications  by  TÜV  SÜD  followed  TÜV  SÜD’s  inspection  at  Silimed’s  manufacturing  facilities  in  Brazil,  relating  to  the
alleged presence of surface particles on Silimed breast products. Breast implants have stringent standards for manufacturing and
robust quality systems, but there is no specific or defined standard for surface particles on breast implants. MHRA noted that no
risks to patient health have been identified in connection with implanting Silimed-manufactured products, and, accordingly, there
is no need to adopt any procedure or action for those patients who have received them.

On October 2, 2015, the Brazilian regulatory agency ANVISA and the Department of the Secretary of State of the State
of Rio de Janeiro announced suspension of the manufacturing and shipment of all medical devices made by Silimed, including
products  manufactured  for  Sientra,  while  they  continue  to  review  the  technical  compliance  related  to  cGMP,  of  Silimed’s
manufacturing  facility.  ANVISA  reiterated  that  no  risks  to  patient  health  have  been  identified  in  connection  with  implanting
Silimed-manufactured products, and, accordingly, there is no need to adopt any procedure or action for those patients who have
received them. Furthermore, ANVISA also indicated that, based on its contact to date with foreign regulatory authorities, there
have been no reports of adverse events related to this issue.

On October 9, 2015, the Company voluntarily placed a hold on the sale of all Sientra devices manufactured by Silimed
and  recommended  that  plastic  surgeons  discontinue  implanting  the  devices  until  further  notice.    The  Company  had  ongoing
discussions  with  the  FDA  regarding  European  and  Brazilian  regulatory  inquiries  into  Silimed-manufactured  products,  and  the
Company  conducted  its  own  review  of  the  matter  with  the  assistance  of  independent  experts  in  quality  management  systems,
cGMP and data-based risk assessment.  The FDA also reiterated that no reports of adverse events and no risks to patient health
had been identified in connection with implanting Silimed-manufactured products.

On January 27, 2016, after completing an analysis and risk assessment, ANVISA announced its authorization of Silimed
to resume the commercialization and use of its previously manufactured products.  ANVISA concluded there was no evidence to
prove that the presence of surface particles on the silicone implants represented risks which are additional to the ones inherent in
the  product.    However,  Silimed  would  continue  to  be  suspended  from  manufacturing  and  commercializing  new  batches  of
implants until an inspection was performed to reassess the fulfillment of its GMP compliance.

On  March  1,  2016,  after  the  completion  of  extensive  independent,  third-party  testing  and  analyses  of  its  devices
manufactured by Silimed, the Company lifted the temporary hold on the sale of such devices and informed its Plastic Surgeons of
the  Company’s  controlled  market  re-entry  plan  designed  to  optimize  the  Company’s  inventory  supply.  The  results  of  the
Company’s testing  indicate  no  significant  safety  concerns  with the  use of  its products,  including  its breast  implants,  consistent
with their approval status since 2012.

On  July  11,  2016,  after  completing  an  inspection  of  Silimed’s  facility,  ANVISA  announced  the  reinstatement  of
Silimed’s GMP certificate and their ability to manufacture commercial products. The Brazilian GMP certificate is effective as of
July 8, 2016 and is valid for two years. The Silimed facility that has been approved for manufacturing is a different facility from
where Sientra breast implants were previously manufactured, which was damaged by a fire on October 22, 2015, and it remains
unclear as to whether this different facility is fully equipped to manufacture Sientra’s silicone gel breast implants. Moreover, even
if this different facility was equipped to manufacture Sientra’s silicone gel breast implants, such products cannot be sold in the
U.S. until a PMA supplement for that facility is submitted, Silimed’s operations have been fully validated to U.S. FDA standards
and  they  have  successfully  passed  an  FDA  inspection,  the  timing  of  which  remains  uncertain.  Additionally,  the  suspension  of
Silimed’s  CE  and  ISO  13485  certifications  by  TÜV  SÜD  remains  in  place  and  continues  to  limit  Silimed’s  ability  to  sell  to
countries  requiring  a  CE  mark.  The  Company’s  existing  manufacturing  contract  with  Silimed  expires  on  its  terms  on  April  1,
2017.

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For  more  information  on  the  status  of  the  Company’s  relationship  with  Silimed,  see  Note  9—Commitments  and

Contingencies.

(2) Summary of Significant Accounting Policies

(a) Basis of Presentation and Use of Estimates

The  preparation  of  financial  statements  in  conformity  with  accounting  principles  generally  accepted  in  the  United  States  of
America,  or  GAAP,  requires  management  to  make  estimates  and  assumptions  that  affect  the  reported  amounts  of  assets  and
liabilities and the disclosure of contingent assets and liabilities at the dates of the financial statements, and the reported amounts
of  revenues  and  expenses  during  the  reporting  period.  Actual  results  could  differ  from  those  estimates.  Assets  and  liabilities
which are subject to significant judgment and use of estimates include the allowance for doubtful accounts, sales return reserves,
provision  for  warranties,  valuation  of  inventories,  recoverability  of  long-lived  assets,  valuation  allowances  with  respect  to
deferred tax assets, useful lives associated with property and equipment and finite lived intangible assets, and the valuation and
assumptions underlying stock-based compensation and other equity instruments. On an ongoing basis, the Company evaluates its
estimates compared to historical experience and trends, which form the basis for making judgments about the carrying value of
assets  and  liabilities.  In  addition,  the  Company  engages  the  assistance  of  valuation  specialists  in  concluding  on  fair  value
measurements in connection with stock-based compensation and other equity instruments.

(b) Liquidity

Since inception, the Company has incurred net losses. During the years ended December 31, 2016, 2015, and 2014 the
Company incurred net losses of $40.2 million, $41.2 million, and $5.8 million, respectively. The Company used $34.4 million of
cash in operations for the year ended December 31, 2016, used $18.2 million cash in operations during the year ended December
31, 2015 and provided $0.5 million of cash in operations during the year ended December 31, 2014. At December 31, 2016 and
2015  the  Company  had  an  accumulated  deficit  of  $215.4  million  and  $175.3  million,  respectively.  At  December  31, 2016,  the
Company had cash and cash equivalents of $67.2 million. The accompanying financial statements have been prepared on a going
concern basis, which implies the Company will continue to realize its assets and discharge its liabilities in the normal course of
business.  As of  December  31,  2016, the  Company’s  existing  manufacturing  contract  with  Silimed,  the  Company’s  former  sole
source, third-party manufacturer of silicone gel breast implants expires on its terms on April 1, 2017, and the Company does not
intend  to  renew  that  contract  with  Silimed.    Accordingly,  the  Company  continues  to  evaluate  the  availability  of  alternative
manufacturing  sources,  including  with  Vesta  Intermediate  Funding,  Inc.,  or  Vesta,  a  Lubrizol  Lifesciences  company,  which  is
establishing manufacturing capacity for the Company and with which the Company recently executed a definitive manufacturing
agreement  for  the  long-term  supply  of  the  Company’s  PMA-approved  breast  implants.  The  continuation  of  the  Company  as  a
going  concern  is  dependent  upon  many  factors  including  resolution  of  any  outstanding  disputes  with  Silimed  (see  Note  9—
Commitments  and  Contingencies),  the  availability  of  alternative  manufacturing  sources,  and  continued  sale  of  the  Company’s
products. The Company believes that it has the ability to continue as a going concern for at least 12 months from the date the
Company’s financial statements are issued. These financial statements do not include any adjustments to the recoverability and
classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to
continue as a going concern.

(c) Cash and Cash Equivalents

The Company considers all highly liquid investments purchased with an original maturity of three months or less when purchased
to  be  cash  equivalents.  Cash  and  cash  equivalents  consist  primarily  of  cash  in  checking  accounts  and  interest-bearing  money
market accounts.

(d) Concentration of Credit and Supplier Risks

Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily
of  cash  and  cash  equivalents.  The  Company’s  cash  and  cash  equivalents  are  deposited  in  demand  accounts  at  a  financial
institution  that  management  believes  is  creditworthy.  The  Company  is  exposed  to  credit  risk  in  the  event  of  default  by  this
financial institution for cash and cash equivalents in excess of amounts insured by the Federal Deposit Insurance Corporation, or
FDIC. Management believes that the Company’s investments in cash and cash equivalents are

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financially sound and have minimal credit risk and the Company has not experienced any losses on its deposits of cash and cash
equivalents.

The  Company  relies  on  a  limited  number  of  third-party  manufacturers  for  the  manufacturing  and  supply  of  its  products.    This
could  result  in  the  Company  not  being  able  to  acquire  the  inventory  needed  to  meet  customer  demand,  which  would  result  in
possible loss of sales and affect operating results adversely.

(e) Fair Value of Financial Instruments

The  carrying  amounts  of  cash  and  cash  equivalents,  accounts  receivable,  accounts  payable,  accrued  liabilities,  and  customer
deposits are reasonable estimates of their fair value because of the short maturity of these items. The fair value of the common
stock warrant liability is discussed in Note 2.  As of December 31, 2016 and 2015, the Company had no outstanding long-term
debt.

(f) Fair Value Measurements

Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would
be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or
liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair
value must maximize the use of observable inputs and minimize the use of unobservable inputs.

Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels

of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable:

·

·

·

Level 1 — Quoted prices in active markets for identical assets or liabilities.

Level 2 — Observable inputs (other than Level 1 quoted prices) such as quoted prices in active markets for similar assets
or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that
are observable or can be corroborated by observable market data.

Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to determining
the  fair  value  of  the  assets  or  liabilities,  including  pricing  models,  discounted  cash  flow  methodologies  and  similar
techniques.

The  Company’s  common  stock  warrant  liabilities  are  carried  at  fair  value  determined  according  to  the  fair  value
hierarchy  described  above.  The  Company  has  utilized  an  option  pricing  valuation  model  to  determine  the  fair  value  of  its
outstanding  common  stock  warrant  liabilities.  The  inputs  to  the  model  include  fair  value  of  the  common  stock  related  to  the
warrant, exercise price of the warrant, expected term, expected volatility, risk-free interest rate and dividend yield.  The warrants
are  valued  using  the  fair  value  of  common  stock  as  of  the  measurement  date.  The  Company  historically  has  been  a  private
company and lacks company-specific historical and implied volatility information of its stock. Therefore, it estimates its expected
stock volatility based on the historical volatility of publicly traded peer companies for a term equal to the remaining contractual
term  of  the  warrants.  The  risk-free  interest  rate  is  determined  by  reference  to  the  U.S.  Treasury  yield  curve  for  time  periods
approximately equal to the remaining contractual term of the warrants. The Company has estimated a 0% dividend yield based on
the expected dividend yield and the fact that the Company has never paid or declared dividends. As several significant inputs are
not observable, the overall fair value measurement of the warrants is classified as Level 3.

The  Company  assessed  the  fair  value  of  the  deferred  consideration  and  contingent  consideration  for  future  royalty
payments  related  to  the  acquisition  of  bioCorneum®  and  the  contingent  consideration  for  future  milestone  payments  for  the
acquisition of the tissue expander portfolio from SSP using the Monte-Carlo simulation model. Significant assumptions used in
the measurement include future net sales for a defined term and the risk-adjusted discount rate associated with the business. As
the inputs are not observable, the overall, fair value measurement of the deferred consideration and contingent consideration is
classified as Level 3.

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The following tables present information about the Company’s liabilities that are measured at fair value on a recurring
basis as of December 31, 2016 and 2015 and indicate the level of the fair value hierarchy utilized to determine such fair value (in
thousands):

Liabilities:

Liability for common stock warrants
Liability for deferred consideration
Liability for contingent consideration

Liabilities:

Liability for common stock warrants

Fair Value Measurements as of
December 31, 2016 Using:
       Level 2        Level 3       

     Level 1

  $

  $

—  
—  
—  
 —  

—  
—  
—  
 —  

99  
395  
1,242  
1,736  

Total

99  
395  
1,242  
1,736  

Fair Value Measurements as of
December 31, 2015 Using:
       Level 2        Level 3       

Total

     Level 1

  $
  $

—  
 —  

—  
 —  

60  
60  

60  
60  

The  liability  for  common  stock  warrants  is  included  in  “accrued  and  other  current  liabilities”  and  the  liability  for  the
deferred  consideration  and  contingent  consideration  is  included  in  “warranty  reserve  and  other  long-term  liabilities”  in  the
balance sheet. The following table provides a rollforward of the aggregate fair values of the Company’s common stock warrants,
deferred and contingent consideration for which fair value is determined by Level 3 inputs (in thousands):

Warrant Liability
Balance, December 31, 2015
Increase in fair value through December 31, 2016
Balance, December 31, 2016

Deferred Consideration Liability
Balance, December 31, 2015
Initial fair value of acquisition-related deferred consideration
Change in fair value of deferred consideration
Balance, December 31, 2016

Contingent Consideration Liability
Balance, December 31, 2015
Initial fair value of acquisition-related contingent consideration
Change in fair value of contingent consideration
Balance, December 31, 2016

$

$

$

$

$

$

60  
39  
99  

 —  
434  
(39) 
395  

 —  
1,166  
76  
1,242  

The Company recognizes changes in the fair value of the warrants in “other income (expense), net” in the statement of
operations  and  changes  in  deferred  consideration  and  contingent  consideration  are  recognized  in  “general  and  administrative”
expense in the statement of operations.

(g) Property and Equipment

Property  and  equipment  are  stated  at  cost,  net  of  accumulated  depreciation.  Depreciation  is  computed  using  the  straight‑line
method over the estimated useful life of the asset, generally three years. Leasehold improvements are depreciated over the shorter
of  the  lease  term  or  the  estimated  useful  life  of  the  related  asset.  Upon  retirement  or  sale  of  an  asset,  the  cost  and  related
accumulated  depreciation  or  amortization  are  removed  from  the  balance  sheet  and  any  resulting  gain  or  loss  is  reflected  in
operations in the period realized. Maintenance and repairs are charged to operations as incurred.

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(h) Goodwill and Other Intangible Assets

Goodwill represents the excess of the purchase price over the fair value of net assets of purchased businesses. Goodwill
is not amortized, but instead is subject to impairment tests on at least an annual basis and whenever circumstances suggest that
goodwill  may  be  impaired.  The  Company’s  annual  test  for  impairment  is  performed  as  of  October  1  of  each  fiscal  year.  The
Company  makes  a  qualitative  assessment  of  whether  it  is  more  likely  than  not  that  a  reporting  unit’s  fair  value  is  less  than  its
carrying amount before applying the two‑step goodwill impairment test. If the Company concludes that it is not more likely than
not that the fair value of a reporting unit is less than its carrying amount, it is not required to perform the two‑step impairment test
for that reporting unit.

Under the first step of the test, the Company is required to compare the fair value of a reporting unit with its carrying
amount, including goodwill. If the fair value of a reporting unit exceeds its carrying amount, goodwill of the reporting unit is not
considered impaired and the second step of the test is not performed. If the results of the first step of the impairment test indicate
that the fair value of a reporting unit does not exceed its carrying amount, then the second step of the test is required. The second
step  of  the  test  compares  the  implied  fair  value  of  the  reporting  unit  goodwill  with  the  carrying  amount  of  that  goodwill.  The
impairment loss is measured by the excess of the carrying amount of the reporting unit goodwill over the implied fair value of that
goodwill.

Management  evaluates  the  Company  as  a  single  reporting  unit  for  business  and  operating  purposes  as  all  of  the
Company’s revenue streams are generated by the same underlying products via sales in the United States of America. In addition,
the  majority  of  the  Company’s  costs  are,  by  their  nature,  shared  costs  that  are  not  specifically  identifiable  to  a  geography  or
product line, but relate to all products. As a result, there is a high degree of interdependency among the Company’s net sales and
cash flows for the entity and identifiable cash flows for a reporting unit separate from the entity are not meaningful.

The  Company  tests  indefinite-lived  intangible  assets  for  impairment  on  at  least  an  annual  basis  and  whenever
circumstances suggest the assets may be impaired. The Company’s annual test for impairment is performed as of October 1 of
each  fiscal  year.  If  indicators  of  impairment  are  present,  we  evaluate  the  carrying  value  of  the  intangible  assets  in  relation  to
estimates  of  future  undiscounted  cash  flows.  The  Company  also  evaluates  the  remaining  useful  life  of  an  indefinite-lived
intangible asset to determine whether events and circumstances continue to support an indefinite useful life.

Judgments about the recoverability of purchased finite‑lived intangible assets are made whenever events or changes in
circumstance indicate that impairment may exist. Each fiscal year the Company evaluates the estimated remaining useful lives of
purchased  intangible  assets  and  whether  events  or  changes  in  circumstance  warrant  a  revision  to  the  remaining  periods  of
amortization. Recoverability of finite‑lived intangible assets is measured by comparison of the carrying amount of the asset to the
future undiscounted cash flows the asset is expected to generate. The intangible asset is amortized to the statement of operations
based on estimated cash flows generated from the intangible over its estimated life.

(i) Impairment of Long‑‑Lived Assets

The  Company’s  management  routinely  considers  whether  indicators  of  impairment  of  long‑lived  assets  are  present.  If  such
indicators  are  present,  management  determines  whether  the  sum  of  the  estimated  undiscounted  cash  flows  attributable  to  the
assets in question is less than their carrying value. If less, the Company will recognize an impairment loss based on the excess of
the  carrying  amount  of  the  assets  over  their  respective  fair  values.  Fair  value  is  determined  by  discounted  future  cash  flows,
appraisals  or  other  methods.  If  the  assets  determined  to  be  impaired  are  to  be  held  and  used,  the  Company  will  recognize  an
impairment charge to the extent the present value of anticipated net cash flows attributable to the asset are less than the asset’s
carrying value. The fair value of the asset will then become the asset’s new carrying value. There have been no impairments of
long‑lived  assets  recorded  during  the  years  ended  December  31,  2016,  2015  and  2014.  The  Company  may  record  impairment
losses in future periods if factors influencing its estimates change.

(j) Business Combinations

Business  combinations  are  accounted  for  using  the  acquisition  method  of  accounting.  Under  the  acquisition  method,
assets  acquired  and  liabilities  assumed  are  recorded  at  their  respective  fair  values  as  of  the  acquisition  date  in  our  financial
statements. The excess of the fair value of consideration transferred over the fair value of the net assets acquired is recorded as
goodwill. Contingent consideration obligations incurred in connection with a business combination are

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recorded at their fair values on the acquisition date and remeasured at their fair values each subsequent reporting period until the
related contingencies are resolved. The resulting changes in fair values are recorded in earnings.

(k) Revenue Recognition

The Company sells its product directly to customers in markets where it has regulatory approval. The Company offers a
six-month return policy and recognizes revenue net of sales discounts and returns in accordance with the Financial Accounting
Standards Board, or FASB, Accounting Standards Codification 605, Revenue Recognition, or ASC 605. ASC 605 requires that six
basic criteria must be met before revenue can be recognized when a right of return exists:

·

·

·

·

·

·

the seller’s price to the buyer is substantially fixed or determinable at the date of sale;

the buyer has paid the seller, or the buyer is obligated to pay the seller and the obligation is not contingent on resale
of the product;

the buyer’s obligation to the seller would not be changed in the event of theft or physical destruction or damage of
the product;

the buyer acquiring the product for resale has economic substance apart from that provided by the seller;

the seller does not have significant obligations for future performance to directly bring about resale of the product
by the buyer; and

the amount of future returns can be reasonably estimated.

Appropriate reserves are established for anticipated sales returns based on historical experience, recent gross sales and
any  notification  of  pending  returns.  The  Company  recognizes  revenue  when  title  to  the  product  and  risk  of  loss  transfer  to
customers,  provided there  are no remaining  performance  obligations  required  of the Company or any written matters  requiring
customer acceptance. The Company allows for the return of product from customers within six months after the original sale and
records  estimated  sales  returns  as  a  reduction  of  sales  in  the  same  period  revenue  is  recognized.  Sales  return  provisions  are
calculated based upon historical experience with actual returns. Actual sales returns in any future period are inherently uncertain
and thus may differ from the estimates. If actual sales returns differ significantly from the estimates, an adjustment to revenue in
the current or subsequent period would be recorded. The Company has established an allowance for sales returns of $3.9 million
and $0.7 million as of December 31, 2016 and 2015, respectively, recorded net against accounts receivable in the balance sheet.

A portion of the Company’s revenue is generated from the sale of consigned inventory of breast implants maintained at
doctor,  hospital,  and  clinic  locations.  The  customer  is  contractually  obligated  to  maintain  a  specific  level  of  inventory  and  to
notify the Company upon use. For these products, revenue is recognized at the time the Company is notified by the customer that
the product has been implanted. Notification is usually through the replenishing of the inventory and the Company periodically
reviews  consignment  inventories  to  confirm  accuracy  of  customer  reporting.  FDA  regulations  require  tracking  the  sales  of  all
implanted breast implant products.

Shipping and handling charges are largely provided to customers free of charge. The associated costs are viewed as part
of  the  Company’s  marketing  programs  and  are  recorded  as  a  component  of  sales  and  marketing  expense  in  the  statement  of
operations as an accounting policy election. For the years ended 2016, 2015 and 2014 these costs amounted to $0.6 million, $1.1
million and $1.3 million, respectively.

In other cases, shipping and handling charges may be invoiced to customers based on the amount of products sold. In
such cases, shipping and handling fees collected are recorded as revenue and the related expense as a component of cost of goods
sold.

(l) Accounts Receivable and Allowance for Doubtful Accounts

Accounts  receivable  are  recorded  at  the  invoiced  amount  and  do  not  bear  interest.  The  Company  maintains  allowances  for
doubtful accounts for estimated losses resulting from the inability to collect from some of its customers.

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The  allowances  for  doubtful  accounts  are  based  on  the  analysis  of  historical  bad  debts,  customer  credit‑worthiness,  past
transaction history with the customer, and current economic trends. If the financial condition of the Company’s customers were to
deteriorate,  adversely  affecting  their  ability  to  make  payments,  additional  allowances  may  be  required.  The  Company  has
established an allowance for doubtful accounts of $0.4 million and $0.5 million as of December 31, 2016 and 2015, respectively.

(m) Inventories and Cost of Goods Sold

Inventories  represent  finished  goods  that  are  recorded  at  the  lower  of  cost  or  market  on  a  first‑in,  first‑out  basis,  or
FIFO. The Company periodically assesses the recoverability of all inventories to determine whether adjustments for impairment
or  obsolescence  are  required.  The  Company  evaluates  the  remaining  shelf  life  and  other  general  obsolescence  and  impairment
criteria in assessing the recoverability of the Company’s inventory.

The  Company  recognizes  the  cost  of  inventory  transferred  to  the  customer  in  cost  of  goods  sold  when  revenue

is recognized.

At December 31, 2016 and 2015, approximately $2.0 million and $2.3 million, respectively, of the Company’s inventory

was held on consignment at doctors’ offices, clinics, and hospitals. The value and quantity at any one location is not significant.

(n) Income Taxes

The Company accounts for income taxes under the asset and liability method. Under this method, deferred tax assets and
liabilities  are  determined  based  on  the  difference  between  the  financial  statement  and  tax  bases  of  assets  and  liabilities  using
enacted tax rates in effect for the year in which the differences are expected to affect taxable income. Valuation allowances are
established when necessary to reduce deferred tax assets to the amounts expected to be realized.

The  Company  operates  in  several  tax  jurisdictions  and  is  subject  to  taxes  in  each  jurisdiction  in  which  it  conducts
business. To date, the Company has incurred cumulative net losses and maintains a full valuation allowance on its net deferred tax
assets due to the uncertainty surrounding realization of such assets. However, the Company has deferred tax liabilities associated
with indefinite lived intangible assets that cannot be considered sources of income to support the realization of the deferred tax
assets, and has provided for tax expense and a corresponding deferred tax liability associated with these indefinite lived intangible
assets. Tax expense was $0.1 million and $0.0 million for the years ended December 31, 2016 and 2015, respectively.

The Company accounts for uncertain tax position in accordance with ASC 740‑10, Accounting for Uncertainty in Income Taxes .
The Company assesses all material positions taken in any income tax return, including all significant uncertain positions, in all tax
years that are still subject  to assessment or challenge by relevant taxing authorities.  Assessing an uncertain tax position begins
with the initial determination of the position’s sustainability and is measured at the largest amount of benefit that is greater than
fifty percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions
must be reassessed, and the Company will determine whether (i) the factors underlying the sustainability assertion have changed
and (ii) the amount of the recognized tax benefit is still appropriate. The recognition and measurement  of tax benefits requires
significant  judgment.  Judgments  concerning  the  recognition  and  measurement  of  tax  benefit  might  change  as  new  information
becomes available.

(o) Research and Development Expenditures

Research and development costs are charged to operating expenses as incurred. Research and development, or R&D, primarily
consist  of  clinical  expenses,  regulatory  expenses,  product  development,  consulting  services,  outside  research  activities,  quality
control and other costs associated with the development of the Company’s products and compliance with Good Clinical Practices,
or GCP, requirements. R&D expenses also include related personnel and consultant compensation and stock-based compensation
expense.

(p) Advertising

Expenses related to advertising are charged to sales and marketing expense as incurred. Advertising costs were $0.6 million, $1.0
million and $1.5 million for the years 2016, 2015 and 2014, respectively.

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(q) Stock‑‑Based Compensation

The  Company  applies  the  fair  value  provisions  of  ASC  718,  Compensation  —  Stock  Compensation  ,  or  ASC  718.  ASC  718
requires the recognition of compensation expense, using a fair‑value based method, for costs related to all employee share‑based
payments, including stock options, restricted stock units,   and the employee stock purchase plan. ASC 718 requires companies to
estimate the fair value of share‑based payment awards on the date of grant using an option‑pricing model. We estimate the fair
value of our stock‑based awards to employees and directors using the Black‑Scholes  option  pricing  model.  The grant  date fair
value of a stock‑based award is recognized as an expense over the requisite service period of the award on a straight‑line basis. In
addition,  we  use  the  Monte-Carlo  simulation  option-pricing  model  to  determine  the  fair  value  of  market-based  awards.  The
Monte-Carlo  simulation  option-pricing  model  uses  the  same  input  assumptions  as  the  Black-Scholes  model;  however,  it  also
further incorporates into the fair-value determination the possibility that the market condition may not be satisfied. Compensation
costs related  to these  awards are  recognized  regardless  of whether  the market  condition  is satisfied,  provided  that  the  requisite
service has been provided.

The  option-pricing  models  require  the  input  of  subjective  assumptions,  including  the  risk‑free  interest  rate,  expected
dividend yield, expected volatility and expected term, among other inputs. These estimates involve inherent uncertainties and the
application  of  management’s  judgment.  If  factors  change  and  different  assumptions  are  used,  our  stock‑based  compensation
expense could be materially different in the future. These assumptions are estimated as follows:

·

Risk‑free  interest  rate  —The  risk‑free  interest  rate  is  based  on  the  yields  of  U.S.  Treasury  securities  with  maturities
similar to the expected term of the options for each option group.

· Dividend yield —We have never declared or paid any cash dividends and do not presently plan to pay cash dividends in

the foreseeable future. Consequently, we used an expected dividend yield of zero.

·

·

Expected volatility —As we do  not  have  a  significant  trading  history  for  our  common  stock,  the  expected  stock  price
volatility for our common stock was estimated by taking the average of (i) the median historic price volatility and (ii) the
median of the implied volatility averages, with a three‑month lookback from the valuation date, for any trading options
of  industry  peers  based  on  daily  price  observations  over  a  period  equivalent  to  the  expected  term  of  the  time  to  a
liquidity event. We intend to continue to consistently apply this process using the same or similar public companies until
a  sufficient  amount  of  historical  information  regarding  the  volatility  of  our  own  common  stock  share  price  becomes
available.

Expected term —The expected term represents the period that our stock‑based awards are expected to be outstanding.

The following table presents the weighted‑average assumptions used to estimate the fair value of options granted during

the periods presented:

Stock Options
Expected term (in years)
Expected volatility
Risk-free interest rate
Dividend yield

2016

5.47  

to 6.07  

51 % to

53 %  
1.42 % to 1.54 %  

—

Year Ended December 31,

5.27  

2015
to 6.08  

45 % to

52 %  
1.48 % to 1.92 %  
—

2014

5.77  

to 6.08  

52 % to

57 %  
1.71 % to 2.00 %  
—

In addition to the assumptions used in the option-pricing models, the amount of stock‑based compensation expense we recognize
in our financial statements includes an estimate of stock option forfeitures. We estimate our forfeiture rate based on an analysis of
our actual forfeitures and will continue to evaluate the appropriateness of the forfeiture rate based on actual forfeiture experience,
analysis  of  employee  turnover  and  other  factors.  Changes  in  the  estimated  forfeiture  rate  can  have  a  significant  impact  on  our
stock‑based compensation expense as the cumulative effect of adjusting the rate is recognized in the period the forfeiture estimate
is changed. If a revised forfeiture rate is higher than the previously estimated forfeiture rate, an adjustment is made that will result
in a decrease to the stock‑based compensation expense recognized in the financial statements. If a revised forfeiture rate is lower
than the previously estimated forfeiture rate, an adjustment is made that will result in an increase to the stock‑based compensation
expense recognized in our financial statements.

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The  following  table  presents  the  weighted-average  assumptions  used  to  estimate  the  fair  value  of  the  stock  purchase

rights granted under the employee stock purchase plan:

ESPP
Expected term (in years)
Expected volatility
Risk-free interest rate
Dividend yield

  (r) Product Warranties

2016
to 2.10  

0.50  

Year Ended December 31,
2015

  0.50  

to 2.10  

  0.63  

2014
to 2.14  

58 %  

42 % to

44 %  
0.08 % to 0.85 %   0.08 % to 0.71 %   0.08 % to 0.49 %  
—

42 % to

43 % to

44 %  

—

—

The  Company  offers  a  limited  warranty  and  a  lifetime  product  replacement  program  for  the  Company’s  silicone  gel
breast  implants.  Under  the  limited  warranty,  the  Company  will  reimburse  patients  for  certain  out-of-pocket  costs  related  to
revision  surgeries  performed  within  ten  years  from  the  date  of  implantation  in  a  covered  event.  Under  the  lifetime  product
replacement program, the Company provides no-charge replacement breast implants if a patient experiences a covered event. The
programs are available to all patients implanted with the Company’s silicone breast implants after April 1, 2012 and are subject to
the  terms,  conditions,  claim  procedures,  limitations  and  exclusions.  Timely  completion  of  a  device  tracking  and  warranty
enrollment  form  by  the  patient’s  Plastic  Surgeon  is  required  to  activate  the  programs  and  for  the  patient  to  be  able  to  receive
benefits under either program.

The following table provides a rollforward of the accrued warranties (in thousands):

Beginning balance as of January 1
Payments made during the period
Changes in accrual related to warranties issued during the period
Changes in accrual related to pre-existing warranties
Balance as of December 31

(s) Segment Information

Year Ended December 31,

2016

2015

1,332
(25)
177
(106)
1,378

 $

 $

961
(14)
420
(35)
1,332

 $

 $

Management has determined that it has one business activity and operates in one segment as it only reports financial information
on an aggregate basis to its Chief Executive Officer, who is the Company’s chief operating decision maker. All tangible assets are
held in the United States.

(t) Net Loss Per Share

Net loss (in thousands)
Weighted average common shares outstanding, basic and diluted
Net loss per share attributable to common stockholders

  $

  $

(40,166)  $

(41,230)  $

18,233,177  

15,770,972  

(2.20)  $

(2.61)  $

2016

December 31,
2015

2014

(5,811) 
2,545,371  
(2.28) 

The  Company  excluded  the  following  potentially  dilutive  securities,  outstanding  as  of  December  31,  2016,  2015  and
2014 from the computation of diluted net loss per share attributable to common stockholders for the years ended December 31,
2016, 2015 and 2014 because they had an anti-dilutive impact due to the net loss attributable to common stockholders incurred
for the periods.

Stock options to purchase common stock
Warrants for the purchase of common stock

2016
2,057,296  
47,710  

December 31,

2015
1,967,906  
47,710  

2014
1,613,544  
47,710  

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(u) Recent Accounting Pronouncements

Recently Adopted Accounting Standards

2,105,006  

2,015,616  

1,661,254  

In November 2015, the Financial Accounting Standards Board, or FASB, issued accounting standard update, or ASU,
2015-17,  Balance  Sheet  Classification  of  Deferred  Taxes  ,  which  simplifies  the  presentation  of  deferred  income  taxes.  The
standard  requires  that  deferred  tax  assets  and  liabilities  be  classified  as  noncurrent  on  the  balance  sheet  rather  than  being
separated  into  current  and  noncurrent.  ASU  2015-17  is  effective  for  fiscal  years,  and  interim  periods  within  those  years,
beginning after December 15, 2016. Early adoption is permitted and the standard may be applied either retrospectively or on a
prospective basis to all deferred tax assets and liabilities. The Company early adopted ASU 2015-17 during the third quarter of
2016 on a prospective basis. The adoption of this ASU did not have a significant impact on the Company’s financial statements.

    In  August  2014,  the  FASB  issued  ASU  2014-15,  Presentation 
of 
Financial 
Statement—Going 
Concern
 .  The  standard
was issued to provide guidance about management's responsibility to evaluate whether there is substantial doubt about an entity's
ability  to  continue  as  a  going  concern  and  to  provide  related  footnote  disclosures.  ASU  2014-15  is  effective  for  fiscal  years
ending after December 15, 2016. The Company adopted ASU 2014-15 for the year ended December 31, 2016. The adoption of
this ASU did not have a significant impact on the Company’s financial statements.

Recently Issued Accounting Standards

In May 2014, the FASB issued ASU 2014-09,  Revenue  from Contracts  with Customers  .  The standard was issued to
provide a single framework that replaces existing industry and transaction specific GAAP with a five step analysis of transactions
to determine when and how revenue is recognized. The accounting standard update will replace most existing revenue recognition
guidance  in  GAAP when  it  becomes  effective.  In  August  2015,  the  FASB issued  ASU 2015-14,  Revenue  from  Contracts  with
Customers (Topic 606): Deferral of the Effective Date, to defer the effective date of ASU 2014-09 by one year.  Therefore, ASU
2014-09  will  become  effective  for  the  Company  beginning  in  fiscal  year  2018.  Early  adoption  would  be  permitted  for  the
Company beginning in fiscal year 2017. The standard permits the use of either the retrospective or cumulative transition method.  
In  December  2016,  the  FASB  issued  ASU  2016-20,  Technical  Corrections  and  Improvements  to  Topic  606,  Revenue  from
Contracts with Customers. ASU 2016-20 is intended to clarify and suggest improvements to the application of current standards
under  Topic  606  and  other  Topics  amended  by  ASU  2014-09,  Revenue  from  Contracts  with  Customers  (Topic  606)  .  The
effective  date  of  ASU 2016-20  is  the  same  as  the  effective  date  for  ASU 2014-09.  In preparation  for our  adoption  of the new
standard  in  our  fiscal  year  ending  December  31,  2018,  we  are  reviewing  contracts  and  other  forms  of  agreements  with  our
customers and are evaluating the provisions contained therein in light of the five-step model specified by the new guidance. That
five-step model includes: (1) determination of whether a contract—an agreement between two or more parties that creates legally
enforceable rights and obligations—exists; (2) identification of the performance obligations in the contract; (3) determination of
the transaction price; (4) allocation of the transaction price to the performance obligations in the contract; and (5) recognition of
revenue when (or as) the performance obligation is satisfied. We are also evaluating the impact of the new standard on certain
common practices currently employed by us and by other medical device companies, such as allowance for sales returns, rebates
and other pricing programs. We have not yet determined the impact of the new standard on our financial statements or whether
we will adopt on a prospective or retrospective basis in the first quarter of our fiscal year ending December 31, 2018.

In  February  2016,  the  FASB  issued  ASU  2016-02,  Leases  (Topic  842)  which supersedes FASB Accounting Standard
Codification Leases (Topic 840). The standard is intended to increase the transparency and comparability among organizations by
recognizing lease assets and lease liabilities on the balance sheet and disclosing key information about leasing arrangements. This
accounting standard update will be effective for the Company beginning in fiscal year 2019. The Company is currently evaluating
the impact that adoption of the standard will have on the financial statements and related disclosures.

In  March  2016,  the  FASB  issued  ASU  2016-09,  Compensation  –  Stock  Compensation  (Topic  718).  The  standard
identifies  areas  for  simplification  involving  several  aspects  of  accounting  for  share-based  payment  transactions,  including  the
income tax consequences, classification of awards as either equity or liabilities, an option to recognize gross stock compensation
expense with actual forfeitures recognized as they occur, as well as certain classifications on the statement

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of cash flows. This accounting standard update will be effective for the Company beginning in fiscal year 2017. The Company is
currently evaluating the impact that adoption of the standard will have on the financial statements and related disclosures.

In August 2016, the FASB issued ASU 2016-15,  Statement of Cash Flows – Classifications of Certain Cash Receipts
and  Cash  Payments  (Topic  230)  .  The  standard  update  addresses  eight  specific  cash  flow  issues  not  currently  addressed  by
GAAP, with the objective of reducing the existing diversity in practice of how these cash receipts and payments are presented and
classified in the statement of cash flows. This accounting standard update will be effective for the Company beginning in fiscal
year 2018. The Company is currently evaluating the impact that adoption of the standard will have on the financial statements and
related disclosures.

In January  2017,  the  FASB issued  ASU 2017-01,  Business Combinations (Topic 805) - Clarifying the Definition of a
Business  .  The  standard  adds  guidance  to  assist  entities  with  evaluating  whether  transactions  should  be  accounted  for  as
acquisitions (or disposals) of assets or businesses by providing a more specific definition of a business. The updated accounting
standard will be effective for the Company beginning in fiscal year 2018. This ASU currently has no impact on the Company;
however, the Company will evaluate the impact of this ASU on future business acquisitions .

In January 2017, the FASB issued ASU 2017-04, I ntangibles - Goodwill and Other (Topic 350) - Simplifying the Test
for Goodwill Impairment . The standard update eliminates Step 2 from the goodwill impairment test. The guidance requires an
entity to perform its annual, or interim, goodwill impairment test by comparing the fair value of a reporting unit with its carrying
amount. An entity should recognize  an impairment  charge for the amount by which the carrying amount exceeds the reporting
unit’s  fair  value.  In  addition,  the  guidance  eliminates  the  requirements  for  any  reporting  unit  with  a  zero  or  negative  carrying
amount to perform a qualitative assessment. The standard will be effective for the Company beginning in fiscal year 2020. Early
adoption  is  permitted  for  interim  and  annual  goodwill  impairment  tests  performed  after  January  1,  2017.    The  Company  is
currently evaluating the impact that adoption of the standard will have on the financial statements and related disclosures.

(3) Acquisitions

(a) Acquisition of bioCorneum®

On  March  9,  2016,  the  Company  entered  into  an  asset  purchase  agreement  with  Enaltus  LLC,  or  Enaltus,  to  acquire
exclusive U.S. rights to bioCorneum®, an advanced silicone scar treatment marketed exclusively to physicians. The acquisition of
bioCorneum®  aligns  with  the  Company’s  business  development  objectives  and  adds  a  complementary  product  that  serves  the
needs of its customers. In connection with the acquisition, the Company recorded $0.2 million of professional fees for the year
ended December 31, 2016, which is included in general and administrative expense. The aggregate preliminary acquisition date
fair value of the consideration transferred was estimated at $7.4 million, which consisted of the following (in thousands):

Cash
Deferred consideration
Contingent consideration

$

$

Fair Value

6,859
434
116
7,409

The  deferred  consideration  and  contingent  consideration  consist  of  future  royalty  payments  to  be  paid  on  a  quarterly
basis to Enaltus on future bioCorneum® sales for the 4.5 years beginning January 1, 2024. The Company has determined the fair
value of the deferred consideration and contingent consideration at the acquisition date using a Monte-Carlo simulation model.
The fair value of the deferred consideration is based on the future minimum royalty payments using the risk-free U.S. Treasury
yield curve discount rate. The minimum estimated future payments due under the deferred consideration are $0.5 million. The fair
value of the contingent consideration is based on projected future bioCorneum® sales and a risk-adjusted discount rate. The terms
of the agreement do not provide for a limitation on the maximum potential future payments. The inputs are significant inputs not
observable in the market, which are referred to as Level 3 inputs and are further discussed in Note 5. The deferred consideration
and  contingent  consideration  components  are  classified  as  other  long-term  liability  and  are  subject  to  the  recognition  of
subsequent changes in fair value through general and administrative expense in the statement of operations.

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The  Company  allocated  the  total  consideration  transferred  to  the  tangible  and  identifiable  intangible  assets  acquired
based on their respective fair values on the acquisition date, with the remaining unallocated amount recorded as goodwill. The
goodwill  arising  from  the  transaction  is  primarily  attributable  to  expected  operational  synergies,  and  all  of  goodwill  will  be
deductible  for  income  tax  purposes.  The  financial  statements  for  the  year  ended  December  31,  2016  include  the  results  of
operations of bioCorneum® from the date of acquisition.

The following table summarizes the allocation of the fair value of the consideration transferred by major class for the

business combination completed on March 9, 2016 (in thousands):

Inventory
Prepaid expenses
Goodwill
Intangible assets

March 9,
2016

100
36
3,273
4,000
7,409

$

$

A  summary  of  the  intangible  assets  acquired,  estimated  useful  lives  and  amortization  method  is  as  follows  (in

thousands):

Customer relationships
Trade name

Amount

Estimated useful
life (in years)

$

$

3,200  
800
4,000

10  
12

Amortization
method
Accelerated
Straight-line

The Company retained an independent third-party appraiser to assist management in its valuation and the purchase price
has been finalized. Pro forma results of operations have not been presented because the effect of the acquisition was not material
to the Company's results of operations.

(b) Acquisition of Tissue Expander Portfolio from Specialty Surgical Products, Inc.

On November 2, 2016, the Company entered into an asset purchase agreement with Specialty Surgical Products, Inc., or
SSP,  to  acquire  c  ertain  assets,  consisting  of  the  Dermaspan™,  Softspan™,  and  AlloX2®  tissue  expanders,  from  SSP.  The
acquisition  adds  a  complete  portfolio  of  premium,  differentiated  tissue  expanders  and  aligns  with  the  Company’s  business
development plans for growth in the breast reconstruction market. In connection with the acquisition, the Company recorded $0.1
million of professional fees for the year ended December 31, 2016, which is included in general and administrative expense. The
aggregate preliminary acquisition date fair value of the consideration transferred was estimated at $6.0 million, which consisted
of the following (in thousands):

Cash
Contingent consideration

$

$

Fair Value

4,950
1,050
6,000

The contingent consideration consists of future cash payments of a maximum of $2.0 million to be paid to SSP based
upon  the  achievement  of  certain  milestones  of  future  net  sales.  The  Company  has  determined  the  fair  value  of  the  contingent
consideration at the acquisition date using a Monte-Carlo simulation model. The inputs include the estimated amount and timing
of  future  net  sales,  and  a  risk-adjusted  discount  rate.  The  inputs  are  significant  inputs  not  observable  in  the  market,  which  are
referred to as Level 3 inputs and are further discussed in Note 5. The contingent consideration components are classified as other
long-term  liabilities  and  are  subject  to  the  recognition  of  subsequent  changes  in  fair  value  through  general  and  administrative
expense in the statement of operations.

The Company allocated the total consideration transferred to the tangible and identifiable intangible assets acquired and

liabilities assumed based on their respective fair values on the acquisition date, with the remaining unallocated

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amount  recorded  as  goodwill.  The  goodwill  arising  from  the  transaction  is  primarily  attributable  to  expected  operational
synergies,  and  all  of  goodwill  will  be  deductible  for  income  tax  purposes.  The  financial  statements  for  the  year  ended
December 31, 2016 include the results of operations of the Dermaspan™, Softspan™, and AlloX2® tissue expanders from the
date of acquisition.

The following table summarizes the allocation of the fair value of the consideration transferred by major class for the

business combination completed on November 2, 2016 (in thousands):

Accounts receivable, net
Inventory
Equipment
Goodwill
Intangible assets
Liabilities assumed

November 2,
2016

196
1,555
34
1,605
2,860
(250)
6,000

$

$

A  summary  of  the  intangible  assets  acquired,  estimated  useful  lives  and  amortization  method  is  as  follows  (in

thousands):

Customer relationships
Regulatory approvals
Trade names

Amount

1,740  
670  
450  

2,860

$

$

Estimated useful
life

9 years  
14 months  
indefinite-lived  

Amortization
method
Accelerated
Straight-line

The Company retained an independent third-party appraiser to assist management in its valuation; however, the purchase
price allocation has not been finalized. The primary areas of the preliminary purchase price allocation that are not yet finalized
relate to the fair values of certain tangible assets and liabilities acquired, the valuation of intangible assets acquired, and residual
goodwill. The Company expects to continue to obtain information to assist in determining the fair value of the net assets acquired
at  the  acquisition  date  during  the  measurement  period.  The  preliminary  allocation  of  the  purchase  price  is  based  on  the  best
estimates of management and is subject to revision based on the final valuations and estimates of useful lives.

Pro  forma  results  of  operations  have  not  been  presented  because  the  effect  of  the  acquisition  was  not  material  to  the

Company's results of operations.

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(4) Balance Sheet Components

Property and equipment, net consist of the following (in thousands):

Leasehold improvements
Laboratory equipment and toolings
Computer equipment
Software
Office equipment
Furniture and fixtures

Less accumulated depreciation

December 31,

2016

2015

$

$

86   $

2,264  
287  
669  
129  
743  
4,178  
(1,192) 
2,986   $

86  
366  
277  
655  
137  
724  
2,245  
(841) 
1,404  

Depreciation expense for the years ended December 31, 2016,  2015 and 2014 was $0.4 million, $0.3 million and

$0.2 million, respectively.

Accrued and other current liabilities consist of the following:

Accrued clinical trial and research and development expenses
Audit, consulting and legal fees
Payroll and related expenses
Accrued commission
Warrant liability
Other

(5)   Goodwill and Other Intangible Assets, net

(a) Goodwill

December 31,

2016

2015

119  
803  
2,592  
1,222  
99  
1,672  
6,507  

$

$

215  
1,208  
2,494  
1,960  
60  
1,022  
6,959  

$

$

The Company has determined that it has one reporting unit and evaluates goodwill for impairment at least annually on

October 1  and whenever circumstances suggest that goodwill may be impaired.

st 

The changes in the carrying amount of goodwill during the years ended December 31, 2016 and 2015 were as follows

(in thousands):

Balances as of December 31, 2014

Goodwill
Accumulated impairment losses
Goodwill, net

Goodwill impairment

Balances as of December 31, 2015

Goodwill
Accumulated impairment losses
Goodwill, net

Goodwill acquired (Note 3)

$

$

$

$

14,278  
 —  
14,278  

(14,278) 

14,278  
(14,278) 
 —  

4,878  

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Balances as of December 31, 2016

Goodwill
Accumulated impairment losses
Goodwill, net

$

$

19,156  
(14,278) 
4,878  

On September 24, 2015, the Company experienced a significant decline in its common stock price, which was sustained
through September 30, 2015. The significant decline in the Company’s common stock price for a sustained period, along with the
impact from regulatory inquiries related to medical devices manufactured by Silimed, the Company’s contract manufacturer, were
identified as potential indicators of impairment of goodwill and other intangibles. As a result, the Company was required to assess
whether or not an impairment of its goodwill had occurred as of September 30, 2015. The Company assessed the impact of the
recent  downward  volatility  in  the  Company's  common  stock  price  and  concluded  that  the  sustained  decline  constituted  a
triggering event requiring an interim goodwill impairment test. The Company conducted the first step of the goodwill impairment
test  described  above  for  its  single  reporting  unit  as  of  September  30,  2015.  The  fair  value  of  the  reporting  unit  exceeded  its
carrying value as of September 30, 2015 by 24.7%, and therefore goodwill was determined to not be impaired as of September 30,
2015.

As  a  result  of  the  actions  taken  by  the  Brazilian  regulatory  agency  ANVISA  on  October  2,  2015,  the  Company
voluntarily placing a hold on the sale of all Sientra devices manufactured by Silimed on October 9, 2015, and the burning down of
Silimed’s  facility  for  manufacturing  Sientra’s  breast  implants  on  October  22,  2015,  the  Company  experienced  a  significant
decline in its common stock price, which was sustained through December 31, 2015. The significant decline in the Company’s
common  stock  price  for  a  sustained  period,  along  with  the  impact  from  recent  regulatory  inquiries  related  to  medical  devices
manufactured  by  Silimed,  the  Company’s  contract  manufacturer,  and  the  fire  at  Silimed’s  facility  for  manufacturing  Sientra’s
breast implants, were identified as potential indicators of impairment of goodwill and the Company concluded that these events
constituted a triggering event requiring a goodwill impairment test. The Company conducted a step one analysis which consists of
a comparison of the fair value of the Company as a single reporting unit using a market approach against its carrying amount,
including  goodwill.    As  a  result  of  the  step  one  analysis,  it  was  determined  that  the  carrying  value  exceeded  its  fair  value;
therefore,  the  Company  proceeded  to  step  two  of  the  goodwill  impairment  analysis.  For  step  two,  the  Company  compared  the
implied fair value of goodwill with the carrying amount of goodwill and based on the analysis, there was no implied goodwill;
therefore, the Company recorded a goodwill impairment charge of  $14.3 million for the quarter ended December 31, 2015.

The Company conducted the annual goodwill impairment test in the fourth quarter of 2016 and determined goodwill had

not been impaired for the year ended December 31, 2016.

(b) Other Intangible Assets

The  components  of  the  Company’s  other  intangible  assets  consist  of  the  following  definite-lived  and  indefinite-lived

assets (in thousands):

Intangibles with definite lives
Acquired FDA non-gel product approval
Customer relationships
Trade names - finite life
Regulatory approvals
Non-compete agreement
Total definite-lived intangible assets

Intangibles with indefinite lives
Trade names - indefinite life
Total indefinite-lived intangible assets

December 31, 2016

  Gross Carrying   Accumulated

Amount

Amortization  

Intangible
Assets, net

$

$

$

1,713   $
4,940  
800  
670  
80  
8,203   $

(1,696)  $
(602) 
(56) 
(96) 
(17) 
(2,467)  $

450  
450   $

 —  
 —   $

December 31, 2015

17
4,338
744
574
63
5,736

450
450

Average
Amortization
Period
(in years)
11
9.5
12
1.17
2.0

—

Average
Amortization

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Intangibles with definite lives
Acquired FDA non-gel product approval
Total definite-lived intangible assets

Period
(in years)
11

  Gross Carrying   Accumulated

Amount

Amortization  

Intangible
Assets, net

$
$

1,713   $
1,713   $

(1,660)  $
(1,660)  $

53
53

Amortization  expense  for  the  year  ended  December  31,  2016,    2015  and  2014  was  $0.8  million,    $0.1  million  and
$0.1  million,  respectively.  The  following  table  summarizes  the  estimated  amortization  expense  relating  to  the  Company's
intangible assets as of December 31, 2016 (in thous ands) :

Period
2017
2018
2019
2020
2021

Amortization
Expense

1,708
1,090
794
582
435
4,609

$

$

(6) Income Taxes

The provision for income tax consists of the following:

Deferred tax
  Federal
  State

2016

Year Ended
December 31,

2015

  $

  $

55   $
6    
61   $

2014

 —
 —
 —

 —   $
 —    
 —   $

Actual income tax expense differs from that obtained by applying the statutory federal income tax rate of 34% to income

before income taxes as follows (in thousands):

Tax at federal statutory rate
State, net of federal benefit
Permanent items
Research and development credits
Benefit state rate change
Other
Change in valuation allowance

Year Ended
December 31,

2015

(14,018)  $
(1,624)   
898    
 —    
180    
1    
14,563    
 —   $

2014

(1,976) 
(260) 
580  
(216) 
(941) 
495  
2,318  
 —  

  $

  $

2016

(13,636)  $
(1,321) 
1,420  
 —  
87  
9  
13,502  

61   $

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The tax effects of temporary differences and carryforwards that give rise to significant portions of the deferred tax assets

are as follows (in thousands):

Net operating loss carryforwards
Research and development credits
Depreciation
Accruals and reserves
Intangibles

Less valuation allowance
Total deferred tax assets

Depreciation
Indefinite-lived intangibles (naked credit)
Total deferred tax liabilities

December 31,

2016

2015

65,626  
2,233  
 —  
4,362  
8,309  
80,530  
(80,470) 
60  

(60) 
(61) 
(121)

$

$

 $

53,244  
2,233  
26  
1,900  
9,565  
66,968  
(66,968) 
 —  

 —  
 —  
 —  

$

$

 $

As a result of the realization requirements of ASC 718, the table of deferred tax assets and liabilities does not include
approximately  $0.1  million  and  $0.1  million  of  deferred  tax  assets,  as  of  December  31,  2016  and  December  31,  2015,
respectively,  that  arose  directly  from  tax  deductions  related  to  equity  compensation  that  are  greater  than  the  compensation
recognized for financial reporting.

The  Company  has  established  a  full  valuation  allowance  against  its  net  deferred  tax  assets  due  to  the  uncertainty

surrounding realization of such assets.

As  of  December  31,  2016,  the  Company  had  net  operating  loss  carryforwards  of  approximately  $170.9  million  and
$144.3  million  available  to  reduce  future  taxable  income,  if  any,  for  federal  and  state  income  tax  purposes,  respectively.  The
federal net operating loss carryforward begins expiring in 2027, and the state net operating loss carryforwards begin expiring in
2017.  It  is  possible  that  the  Company  will  not  generate  taxable  income  in  time  to  use  these  NOLs  before  their  expiration.  In
addition,  under  Section  382  of  the  Internal  Revenue  Code  of  1986,  as  amended,  or  the  Code,  if  a  corporation  undergoes  an
“ownership  change”,  the  corporation's  ability  to  use  its  pre-change  NOL  carryforwards  and  other  pre-change  tax  attributes  to
offset its post-change income may be limited.  In general, an “ownership change” occurs if there is a cumulative change in a loss
corporation’s ownership by 5% shareholders that exceeds 50 percentage points over a rolling three-year period.  The Company
has not performed a detailed analysis to determine whether an ownership change under Section 382 of the Code has previously
occurred. As a result, if the Company earns net taxable income, its ability to use their pre-change net operating loss carryforwards
to  offset  U.S.  federal  taxable  income  may  become  subject  to  limitations,  which  could  potentially  result  in  increased  future  tax
liability  to  the  Company.  Until  such  analysis  is  completed,  the  Company  cannot  be  sure  that  the  full  amount  of  the  existing
federal NOLs will be available to them, even if taxable income is generated before their expiration.

As  of  December  31,  2016,  the  Company  had  research  and  development  credit  carryforwards  of  approximately  $1.8
million and $1.8 million available to reduce future taxable income, if any, for federal and California state income tax purposes,
respectively. The federal credit carryforwards begin expiring in 2027 and the state credits carryforward indefinitely.

At December 31, 2016, the Company had unrecognized tax benefits of approximately $0.7 million associated with the
research and development credits. All of the unrecognized tax benefits that, if recognized, would affect the annual effective rate.
The Company does not anticipate that total unrecognized net tax benefits will significantly change over the next twelve months.

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A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

Ending balance at December 31, 2014
Additions based on tax positions taken in the current year
Ending balance at December 31, 2015
Additions based on tax positions taken in the current year
Ending balance at December 31, 2016

$

$

732
 —
732
 —
732

It  is  the  Company’s  policy  to  include  penalties  and  interest  expense  related  to  income  taxes  as  a  component  of  other
expense and interest expense, respectively, as necessary. There was no interest expense or penalties related to unrecognized tax
benefits recorded through December 31, 2016.

The  Company  files  U.S.  federal  and  state  income  tax  returns  in  jurisdictions  with  varying  statute  of  limitations.  The
years that may be subject to examination will vary by jurisdiction. The Company’s tax years 2012 to 2016 will remain open for
examination by the federal and state tax authorities.

(7)   Employee Benefit Plans

In  September  2016,  the  Company  adopted  a  Section  401(k)  Retirement  Savings  Plan  for  the  benefit  of  eligible
employees.  All  employees  become  eligible  to  participate  in  the  plan  the  first  of  the  month  following  their  hire  date  and  may
contribute  their  pretax  or  after–tax  salary,  up  to  the  Internal  Revenue  Service  annual  contribution  limit.  The  Company  makes
contributions  to  the  401(k)  plan  under  a  safe  harbor  provision,  whereby  the  Company  contributes  3%  of  each  participating
employee’s annual compensation. Company contributions vest immediately. The Company contributed and included in operating
expense $0.1 million for the year ended December 31, 2016.

(8)   Stockholders’ Equity

(a)

Authorized Stock

The Company’s Amended and Restated Certificate of Incorporation authorizes the Company to issue 210,000,000 shares
of common and preferred stock, consisting of 200,000,000 shares of common stock with $0.01 par value and 10,000,000 shares of
preferred stock with $0.01 par value. As of December 31, 2016, the Company had no preferred stock issued or outstanding.

(b)

Common Stock Warrants

On January 17, 2013, the Company entered into a Loan and Security Agreement, or the Original Term Loan Agreement,
with Oxford Finance, LLC, or Oxford. On June 30, 2014, the Company entered into the Amended and Restated Loan and Security
Agreement, or the Amended Term Loan Agreement, with Oxford. In connection with the Original Term Loan Agreement and the
Amended Term Loan Agreement, the Company issued to Oxford (i) seven-year warrants in January 2013 to purchase shares of
the  Company’s  common  stock  with  a  value  equal  to  3.0%  of  the  tranche  A,  B  and  C  term  loans  amounts  and  (ii)  seven-year
warrants in June 2014 to purchase shares of the Company’s common stock with a value equal to 2.5% of the tranche D term loan
amount.  The warrants have an exercise price per share of $14.671. As of December 31, 2016, there were warrants to purchase an
aggregate of 47,710 shares of common stock outstanding.

(c)

Stock Option Plans

In  April  2007,  the  Company  adopted  the  2007  Equity  Incentive  Plan,  or  2007  Plan.  The  2007  Plan  provides  for  the
granting  of  stock  options  to  employees,  directors  and  consultants  of  the  Company.  Options  granted  under  the  2007  Plan  may
either be incentive stock options or nonstatutory stock options. Incentive stock options, or ISOs, may be granted only to Company
employees.    Nonstatutory  stock  options,  or  NSOs,  may  be  granted  to  all  eligible  recipients.  A  total  of  1,690,448  shares  of  the
Company’s common stock were reserved for issuance for the 2007 Plan.

As  of  December  31,  2016,  pursuant  to  the  2007  Plan,  there  were  1,054,096  options  outstanding  and  no  shares  of

common stock available for future grants.

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The  Company’s  board  of  directors  adopted  the  2014  Equity  Incentive  Plan,  or  2014  Plan,  in  July  2014,  and  the
stockholders approved the 2014 Plan in October 2014. The 2014 Plan became effective upon completion of the IPO on November
3, 2014, at which time the Company ceased granting awards under the 2007 Plan. Under the 2014 Plan, the Company may issue
ISOs, NSOs, stock appreciation rights, restricted stock awards, restricted stock unit awards and other forms of stock awards, or
collectively, stock awards, all of which may be granted to employees, including officers, non-employee directors and consultants
of the Company and their affiliates. ISOs may be granted only to employees.  A total of 1,027,500 shares of common stock were
initially reserved for issuance under the 2014 Plan, subject to certain annual increases.

As  of  December  31,  2016,  pursuant  to  the  2014  Plan,  there  were  2,045,495  shares  of  common  stock  reserved  and

207,381 shares of common stock available for future grants.

Pursuant  to  a  board-approved  Inducement  Plan,  the  Company  may  issue  NSOs  and  restricted  stock  unit  awards,  or
collectively, stock awards, all of which may only be granted to new employees of the Company and their affiliates in accordance
with NASDAQ Stock Market Rule 5635(c)(4) as an inducement material to such individuals entering into employment with the
Company.  As of December 31, 2016, inducement grants for 330,000 shares of common stock have been awarded, and 70,000
shares of common stock were reserved for future issuance under the Inducement Plan.

Options  under  the  2007  Plan  and  the  2014  Plan  may  be  granted  for  periods  of  up  to  ten  years  as  determined  by  the
Company’s  board  of  directors,  provided,  however,  that  (i)  the  exercise  price  of  an  ISO  shall  not  be  less  than  100%  of  the
estimated  fair  value  of  the  shares  on  the  date  of  grant,  and  (ii)  the  exercise  price  of  an  ISO  granted  to  a  more  than  10%
shareholder  shall  not  be  less  than  110%  of  the  estimated  fair  value  of  the  shares  on  the  date  of  grant.  An  NSO  has  no  such
exercise price limitations. NSOs under the Inducement Plan may be granted for periods of up to ten years as determined by the
board of directors, provided, the exercise price will be not less than 100% of the estimated fair value of the shares on the date of
grant.  Options generally vest with 25% of the grant vesting on the first anniversary and the balance vesting monthly on a straight-
lined basis over the requisite service period of three additional years for the award. Additionally, options have been granted to
certain  key  executives  that  vest  upon  achievement  of  performance  conditions  based  on  performance  targets  as  defined  by  the
board  of  directors,  which  have  included  net  sales  targets  and  defined  corporate  objectives  over  the  performance  period  with
possible payout ranging from 0% to 100% of the target award.  Compensation expense is recognized on a straight-lined basis over
the vesting term of one year based upon the probable performance target that will be met. The vesting provisions of individual
options may vary but provide for vesting of at least 25% per year.

The following summarizes all option activity under the 2007 Plan, 2014 Plan and Inducement Plan:

Balances at December 31, 2014

Granted
Exercised
Forfeited

Balances at December 31, 2015

Granted
Exercised
Forfeited

Balances at December 31, 2016
Vested and expected to vest at December 31, 2016
Vested and exercisable at December 31, 2016

Option Shares

Weighted
average
exercise price

Weighted average
remaining
contractual
term (year)

1,654,906  
1,253,216  
(36,189) 
(86,261) 
2,785,672  
571,753  
(478,099) 
(92,349) 
2,786,977  
2,786,977  
1,485,534  

$

$

$
$
$

4.25  
10.22  
3.54  
13.38  
6.66  
7.08  
1.93  
15.35  
7.27  
7.27  
6.53  

5.48  

6.60  

6.28  
6.28  

4.50  

The weighted average grant date fair value of stock options granted to employees and directors during the years ended
December 31, 2016, 2015 and 2014 was $3.97,  $4.60, and $6.82 per share, respectively. Stock-based compensation expense for
stock  options  for  the  years  ended  December  31,  2016,    2015  and  2014  was  $1.7  million,  $2.0  million  and  $0.6  million,
respectively. Tax benefits arising from the disposition of certain shares issued upon exercise of stock options within two years of
the  date  of  grant  or  within  one  year  of  the  date  of  exercise  by  the  option  holder,  or  Disqualifying  Dispositions,  provide  the
Company with a tax deduction equal to the difference between the exercise price and the fair

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market value of the stock on the date of exercise. When realized, those excess windfall tax benefits are credited to additional paid-
in  capital.  As  of  December  31,  2016  there  was  $4.3  million  of  total  unrecognized  compensation  cost  related  to  stock  options
granted under the plans. The costs are expected to be recognized over a weighted average period of 2.74 years. The expense is
recorded within the operating expense components in the statement of operations based on the employees receiving the awards.

The  aggregate  intrinsic  value  of  stock  options  is  calculated  as  the  difference  between  the  exercise  price  of  the  stock
options and the fair value of the Company’s common stock for those stock options that had exercise prices lower than the fair
value of the Company’s common stock. The aggregate intrinsic value of stock options exercised was $3.0 million, $0.6 million,
and $0.2 million during the years ended December 31, 2016,  2015 and 2014, respectively.

The expected term of employee stock options, risk‑free interest rate and volatility represents the weighted average, based on grant
date period, which the stock options are expected to remain outstanding. The Company utilized the simplified method to estimate
the expected term of the options pursuant to ASC Subtopic 718‑10 for all option grants to employees. The expected volatility is
based upon historical volatilities of an index of a peer group because it is not practicable to make a reasonable estimate of the
Company’s volatility. The risk‑free interest rate is based on the U.S. Treasury yield curve in effect at the time of the grant for
periods corresponding with the expected term of the option. The dividend yield assumption is based on the Company’s history
and expectation of dividend payouts. The Company has never declared or paid any cash dividends on its common stock, and the
Company does not anticipate paying any cash dividends in the foreseeable future.

As  stock‑based  compensation  expense  recognized  in  the  Company’s  statement  of  operations  is  based  on  awards
ultimately  expected  to  vest,  the  amount  has  been  reduced  for  estimated  forfeitures.  Forfeitures  were  estimated  based  on  the
Company’s historical experience and future expectations.

For purposes of financial accounting for stock‑based compensation, the Company has determined the fair values of its
options  based  in  part  on  the  work  of  a  third‑party  valuation  specialist.  The  determination  of  stock‑based  compensation  is
inherently  uncertain  and  subjective  and  involves  the  application  of  valuation  models  and  assumptions  requiring  the  use  of
judgment.  If  the  Company  had  made  different  assumptions,  its  stock‑based  compensation  expense,  and  its  net  loss  could  have
been significantly different.

(d)

Restricted Stock Units

The Company has issued restricted stock unit awards, or RSUs, under the 2014 Plan. The RSUs issued vest on a straight-

line basis, either quarterly over a 4-year requisite service period or annually over a 3-year requisite service period.

Activity related to RSUs is set forth below:

Balances at December 31, 2014

Granted
Vested

Balances at December 31, 2015

Granted
Vested
Forfeited

Balances at December 31, 2016

Number of shares

Weighted average
grant date
fair value

 —  
17,993  
 —  
17,993  
557,240  
(4,500) 
(140,000) 
430,733  

$

$

$

 —
3.88
 —
3.88
8.21
3.88
8.44
7.99

The weighted average grant date fair value of RSUs granted to employees and directors during the years ended
December 31, 2016 and 2015 was $8.21 and $3.88 per share, respectively. Stock-based compensation expense for RSUs for the
years ended December 31, 2016 and 2015 was $1.2 million and $2,000, respectively. As of December 31, 2016, there was $2.2
million total unrecognized compensation cost related to non-vested RSU awards. The cost is expected to be recognized over a
weighted average period of 1.86 years.

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(e)

Employee Stock Purchase Plan

The  Company’s  board  of  directors  adopted  the  2014  Employee  Stock  Purchase  Plan,  or  ESPP,  in  July  2014,  and  the
stockholders  approved  the  ESPP  in  October  2014.  The  ESPP  allows  eligible  employees  to  purchase  shares  of  the  Company’s
common  stock  at  a  discount  through  payroll  deductions  of  up  to  15%  of  their  eligible  compensation,  subject  to  any  plan
limitations. The ESPP provides offering periods not to exceed 27 months, and each offering period will include purchase periods,
which will be the approximately  six-month period commencing with one exercise date and ending with the next exercise date,
except that the first offering period commenced on the first trading day following the effective date of the Company’s registration
statement.  Employees are able to purchase shares at 85% of the lower of the fair market value of the Company’s common stock
on the first trading day of the offering period or on the exercise date.  A total of 255,500 shares of common stock were initially
reserved for issuance under the ESPP.  The number of shares available for sale under the ESPP will be increased annually on the
first day of each fiscal year, equal to the lesser of i) 1% of the total outstanding shares of the Company’s common stock as of the
last day of the immediately preceding fiscal year; ii) 3,000,000 shares of common stock, or iii) such lesser amount as determined
by the board of directors.

As of December 31, 2016, the number of shares of common stock reserved for issuance under the ESPP was 584,563.
 During the year ended December 31, 2016, employees purchased 122,667 shares under the ESPP at a weighted average exercise
price  of  $6.14  per  share.  During  the  year  ended  December  31,  2015,  employees  purchased  44,250  shares  under  the  ESPP  at  a
weighted average exercise price of $12.75 per share. As of December 31, 2016, the number of shares of common stock available
for future issuance under the ESPP was 417,646. Stock-based compensation related to the ESPP for the years ended December
31, 2016, 2015 and 2014 was $0.3 million,  $0.4 million, and $34,000, respectively.

(9)   Commitments and Contingencies

(a)

Operating Lease Commitment

In August 2013, the Company entered into a four-month warehouse lease in Santa Barbara, California, commencing on
September  1,  2013.  This  operating  lease  is  used  for  additional  general  office,  warehouse,  and  research  and  development.  This
lease has been renewed until January 2019.

In March 2014, the Company entered into  a 68-month lease agreement in Santa Barbara, California. The operating lease

is for general office use only and commenced on July 1, 2014.

The terms of the facility lease provide for rental payments on a graduated scale. The Company recognizes rent expense
on  a  straight-line  basis  over  the  lease  term.  Rent  expense  for  the  years  ended  December  31,  2016,  2015  and  2014  was  $0.5
million, $0.5 million and $0.4 million, respectively.

As of December 31, 2016, future minimum lease payments under all non‑cancelable operating leases are as follows (in

thousands):

Year Ended December 31:

2017
2018
2019
2020
2021 and thereafter

(b)

Separation Agreement

 $

$

532  
520  
436  
72  
 —  
1,560  

On October 26, 2016, Matthew Pigeon resigned from his position as Chief Financial Officer, Senior Vice President and
Treasurer of the Company. The Company entered into a Separation Agreement, or the Separation Agreement, with Mr. Pigeon on
November 7, 2016, pursuant to which, Mr. Pigeon is entitled to receive: (i) twelve (12) months of his base salary as in effect on
the separation date paid in equal installments plus a payment of $78,750 for the remaining 2016 bonus earned by Mr. Pigeon in
connection with the completion of the fiscal year prior to the separation date, consisting of (a) $52,500 payable upon separation
and (b) $26,250 to be paid on January 30, 2017, and (ii) up to twelve (12) months of company-paid health insurance premiums to
continue his coverage. The benefits provided for in the Separation Agreement

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are  consistent  with  the  benefits  that  Mr.  Pigeon  would  have  been  entitled  to  receive  under  his  Amended  and  Restated
Employment Agreement had Mr. Pigeon been terminated without cause. As a result of this Separation Agreement, the Company
incurred $0.4 million in termination benefits which were recorded during the year ended December 31, 2016.

(c)

Contingencies

The Company is subject to claims and assessment from time to time in the ordinary course of business. The Company
accrues  a  liability  for  such  matters  when  it  is  probable  that  future  expenditures  will  be  made  and  such  expenditures  can  be
reasonably estimated.

Hartford

In 2012, the Company filed a claim with the Hartford Insurance Company, or Hartford for reimbursement of legal costs
incurred in connection with litigation with a competitor that was resolved in 2013. The Company held a D&O insurance policy
with Hartford, and the Company and Hartford settled the matter in May 2014. The Company received settlement payments from
Hartford and recovery of costs associated with the litigation of $0,  $0, and $2,358 for the years ended December 31, 2016, 2015
and 2014, respectively.

Class Action Shareholder Litigation

On September 25, 2015, a lawsuit styled as a class action of the Company’s stockholders was filed in the United States
District Court for the Central District of California. The lawsuit names the Company and certain of its officers as defendants, or
the Sientra Defendants, and alleges violations of Sections 10(b) and 20(a) of the Exchange Act in connection with allegedly false
and misleading statements concerning the Company’s business, operations, and prospects.  The plaintiff seeks damages and an
award  of  reasonable  costs  and  expenses,  including  attorneys’  fees.  On  November  24,  2015,  three  stockholders  (or  groups  of
stockholders) filed motions to appoint lead plaintiff(s) and to approve their selection on lead counsel.  On December 10, 2015, the
court  entered  an  order  appointing  lead  plaintiffs  and  approving  their  selection  of  lead  counsel.    On  February  19,  2016,  lead
plaintiffs  filed their consolidated amended  complaint, which added claims  under Sections 11, 12(a)(2)  and 15 of the Securities
Act and named as defendants the underwriters associated with the Company’s follow-on public offering that closed on September
23, 2015, or the Underwriter Defendants. On March 21, 2016, the Sientra Defendants and the Underwriter Defendants each filed a
motion to dismiss, or the Motions to Dismiss, the consolidated amended complaints. On April 20, 2016, lead plaintiffs filed their
opposition to the Motions to Dismiss, and the Sientra Defendants and Underwriter Defendants filed separate replies on May 5,
2016.  On  June  9,  2016,  the  court  granted  in  part  and  denied  in  part  the  Motions  to  Dismiss.    On  July  14,  2016,  the  Sientra
Defendants moved the court to reconsider its June 9, 2016 order and grant the Motions to Dismiss in full. On August 4, 2016, lead
plaintiffs  filed  an  opposition  to  the  motion  for  reconsideration.  On  August  12,  2016,  the  court  denied  the  motion  for
reconsideration, and the Sientra Defendants and the Underwriter Defendants each filed an answer to the consolidated amended
complaint.

On October 28, November 5, and November 19, 2015, three lawsuits styled as class actions of the Company’s stockholders were
filed in the Superior Court of California for the County of San Mateo. The lawsuits name the Company, certain of its officers and
directors,  and the underwriters associated  with the Company’s follow-on public offering  that closed on September  23, 2015 as
defendants. The lawsuits allege violations of Sections 11, 12(a)(2), and 15 of the Securities Act in connection with allegedly false
and misleading statements in the Company’s offering documents associated with the follow-on offering concerning its business,
operations, and prospects. The plaintiffs seek damages and an award of reasonable costs and expenses, including attorneys’ fees.
On  December  4,  2015,  defendants  removed  all  three  lawsuits  to  the  United  States  District  Court  for  the  Northern  District  of
California.  On December 15 and December 16, 2015, plaintiffs filed motions to remand the lawsuits back to San Mateo Superior
Court,  or  the  Motions  to  Remand.    On  January  19,  2016,  defendants  filed  their  opposition  to  the  Motions  to  Remand,  and
plaintiffs filed their reply in support of the Motions to Remand on January 26, 2016. 

On May 20, 2016, the United States District Court for the Northern District of California granted plaintiffs’ Motions to Remand,
and the San Mateo Superior Court received the remanded cases on May 27, 2016.  On July 19, 2016, the San Mateo Superior
Court  consolidated  the  three  lawsuits.    On  August  2,  2016,  plaintiffs  filed  their  consolidated  complaint.  On  August  5,  2016,
defendants  filed  a  motion  to  stay  all  proceedings  in  favor  of  the  class  action  filed  in  the  United  States  District  Court  for  the
Central District of California.

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On September 13, 2016, the parties to the actions pending in the San Mateo Superior Court and the United States District Court
for  the  Central  District  of  California  signed  a  memorandum  of  understanding  that  sets  forth  the  material  deal  points  of  a
settlement that covers both actions and includes class-wide relief. On September 13, 2016 and September 20, 2016, respectively,
the  parties  filed  notices  of  settlement  in  both  courts.  On  September  22,  2016,  the  United  States  District  Court  for  the  Central
District  of  California  stayed  that  action  pending  the  court’s  approval  of  a  settlement.  On  September  23,  2016,  the  San  Mateo
Superior Court stayed that action as well pending the court’s approval of a settlement.

On  December  20,  2016,  the  plaintiffs  in  the  federal  court  action  filed  a  motion  for  preliminary  approval  of  the  class  action
settlement.  On January 23, 2017, the United States District Court for the Central District of California preliminarily approved the
settlement. A final approval hearing in that court is scheduled for May 22, 2017.  On January 5, 2017, the plaintiffs in the state
court  action  also  filed  a  motion  for  preliminary  approval  of  the  class  action  settlement.    On  February  7,  2017,  the  San  Mateo
Superior Court preliminarily approved the settlement.  A final approval hearing in that court is scheduled for May 31, 2017.  The
settlement is contingent upon final approval by both the San Mateo Superior Court and the United States District Court for the
Central District of California.

As  a  result  of  these  developments,  the  Company  has  determined  a  probable  loss  has  been  incurred  and  has  recognized  a  net
charge  to  earnings  of  approximately  $1.6  million  within  general  and  administrative  expense  which  is  comprised  of  the  loss
contingency of approximately $10.9 million, net of expected insurance proceeds of approximately $9.4 million. The Company has
classified  the  loss  contingency  as  “legal  settlement  payable”  and  the  expected  insurance  proceeds  as  “insurance  recovery
receivable” on the accompanying condensed balance sheets. While it is possible that the Company may incur a loss greater than
the amounts recognized in the accompanying financial statements, the Company is unable to determine a range of possible losses
greater than the amount recognized.

Silimed Litigation

On November 6, 2016, Silimed filed a lawsuit in the United States District Court for the Southern District of New York
naming  Sientra  as  the  defendant  and  alleging  breach  of  contract  of  the  Silimed  Agreement,  unfair  competition  and
misappropriation of trade secrets against us.  In its complaint, Silimed alleges that our theft, misuse, and improper disclosure of
Silimed’s  confidential,  proprietary,  and  trade  secret  manufacturing  information  was  done  in  order  for  us  to  develop  our  own
manufacturing capability that we intend to use to manufacture our PMA-approved products.  Silimed is seeking a declaration that
we are in material breach of the Silimed Agreement, a preliminary and permanent injunction to prevent our allegedly wrongful
use  and  disclosure  of  Silimed’s  confidential  and  proprietary  information,  as  well  as  unquantified  compensatory  and  punitive
damages.   On November  15, 2016, Sientra filed  its  answer and counterclaims  for declaratory  judgment in which it denied that
Silimed is entitled to any relief including, among other reasons, because of Silimed’s material breach of the Silimed Agreement
and  Silimed’s  unclean  hands,  and  further  seeks  declaratory  relief  that  Sientra  is  the  owner  of  certain  assets  it  acquired  from
Silimed, Inc. in 2007, that Sientra owns, or is exclusively licensed, to any improvements created since April 2007, that Silimed
lacks any confidential information or proprietary rights under the Silimed Agreement, and that Silimed lacks any relevant trade
secret rights.  On December 9, 2016, Silimed filed a motion to strike the Company’s counterclaims.  Briefing on that motion was
completed on December 30, 2016, and the parties are waiting for a decision from the court.  On February 1, 2017, Sientra filed a
motion to stay Silimed’s breach of contract claim in light of a demand for arbitration filed by Sientra against Silimed on January
20, 2017 concerning Silimed’s material breaches of the Silimed Agreement, and to further dismiss, or alternatively stay, the unfair
competition and misappropriation of trade secrets claims.  Briefing on that motion was completed on February 22, 2017, and the
parties are waiting for a decision from the court.  On February 3, 2017, the court held an initial pre-trial conference and entered a
pre-trial  scheduling  order  which  set  a  final  pre-trial  conference  date  of  August  3,  2018.    We  believe  that  Silimed’s  claims  are
legally and factually unsupported and intend to defend this lawsuit vigorously.

On January 20, 2017, Sientra filed an arbitration demand in the International Center for Dispute Resolution in New York
naming  Silimed  as  the  defendant  and  alleging  material  breach  of  the  Silimed  Agreement,  gross  negligence  and  tortious
interference by Silimed, as well as seeking certain declaratory relief.  Among other things, Sientra alleges that Silimed’s supply
failure constitutes a material breach of the Silimed Agreement, and that such breach was caused by Silimed’s grossly negligent or
other willful conduct related to its regulatory suspensions and the fire at its manufacturing facility.   Silimed filed its answer to
Sientra’s arbitration demand on March 8, 2017.  The parties nominated their party arbitrators on March 13, 2017.

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It is possible that additional suits will be filed, or allegations made by stockholders, with respect to these same or other matters
and also naming the Company and/or its officers and directors as defendants. The Company believes it has meritorious defenses
and intends to defend these lawsuits vigorously. 

(10) Subsequent Events

(a) Manufacturing Agreement with Vesta

On  March  10,  2017,  the  Company  entered  into  a  manufacturing  agreement  with  Vesta  pursuant  to  which  Vesta  shall
manufacture and supply the Company’s breast implant products. The term of the manufacturing agreement is five years, subject
to customary termination rights by either party including termination for a material breach of the agreement. The manufacturing
agreement also contains certain provisions regarding the rights and responsibilities of the parties with respect to manufacturing
specifications,  forecasting  and  ordering,  delivery  arrangements,  payment  terms,  packaging  requirements,  limited  warranties,
confidentiality  and  indemnification,  including  indemnification  by  the  Company  for  a  breach  of  certain  representations  and
warranties related to confidentiality and intellectual property, the breach of which or the failure to provide such indemnity would
qualify as a material breach.

(b) PMA Supplement Submission

On March 13, 2017, the Company submitted a PMA supplement to the FDA for the manufacturing of the Company’s
PMA-approved breast implants by Vesta, pursuant to a manufacturing agreement entered into between the parties on March 10,
2017.

(c ) Loan and Security Agreement with Silicon Valley Bank

On March 13, 2017, the Company entered into a Loan Agreement with SVB. Under the terms of the Loan Agreement,
SVB made available to the Company a revolving line of credit of up to $15.0 million, or the Revolving Line, and a $5.0 million
term  loan,  or  the  Term  Loan.  The  Company  has  not  borrowed  any  amounts  under  the  Revolving  Line  or  the  Term  Loan.  The
Company intends to use the proceeds from the Loan Agreement for working capital and other general corporate purposes.  

Any indebtedness under the Term Loan and the Revolving Line bear interest at a floating per annum rate equal to the
prime  rate  as  reported  in  The  Wall  Street  Journal  plus  1.00%,  which  as  of  the  closing  date  is  3.75%.    The  Term  Loan  has  a
scheduled maturity date of March 1, 2020. The Company must make monthly payments of accrued interest under the Term Loan
from  the  Funding  Date  until  April  1,  2018,  followed  by  monthly  installments  of  principal  and  interest  through  the  term  loan
maturity date. The interest-only period may be extended until April 1, 2019 if the Company has obtained FDA certification of the
manufacturing  facility operated  by Vesta by March 31, 2018. The Company may prepay all, but not less than all, of the Term
Loan  prior  to  its  maturity  date  provided  the  Company  pays  SVB  a  prepayment  charge  based  on  a  percentage  of  the  then-
outstanding principal balance which shall be equal to 2% if the prepayment occurs prior to the second anniversary of the Funding
Date, and 1% if the prepayment occurs thereafter. Upon making the final payment of the Term Loan, whether upon prepayment,
acceleration or at maturity, the Company is required to pay a 12.5% fee on the original principal amount of the Term Loan.

The amount of loans available to be drawn under the Revolving Line is based on a borrowing base equal to 80% of the
Company’s eligible accounts; provided that if the Company maintains an adjusted quick ratio (as defined in the Loan Agreement)
of 1.5:1.0 for three continuous consecutive months, they may access the full Revolving Line. The Company may make (subject to
the applicable borrowing base at the time) and repay borrowings from time to time under the Revolving Line until the maturity of
the facility on March 13, 2022. 

The  Loan  Agreement  includes  customary  affirmative  and  restrictive  covenants  and  representations  and  warranties,
including  a  financial  covenant  to  maintain  the  adjusted  quick  ratio  (as  defined  in  the  Loan  Agreement)  of  1.15:1.0  while
borrowings  are  outstanding  and  until  we  have  obtained  FDA  certification  of  the  manufacturing  facility  operated  by  Vesta,  a
covenant against the occurrence of a “change in control,” financial reporting obligations, and certain limitations on indebtedness,
liens, investments,  distributions (including  dividends), collateral,  mergers  or acquisitions, taxes, corporate changes, and deposit
accounts.  The  Loan  Agreement  also  includes  customary  events  of  default,  including  payment  defaults,  breaches  of  covenants
following  any  applicable  cure  period,  the  occurrence  of  any  “material  adverse  change”  as  set  forth  in  the  Loan  Agreement,
penalties  or  judgements  in  an  amount  of  at  least  $1,000,000  rendered  against  the  Company  by  any  governmental  agency  and
certain  events  relating  to  bankruptcy  or  insolvency.  Upon  the  occurrence  of  an  event  of  default,  a  default  interest  rate  of  an
additional 5.0% may be applied to any outstanding principal balances,

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and SVB may declare all outstanding obligations immediately due and payable and take such other actions as set forth in the Loan
Agreement. The Company’s obligations under the Loan Agreement are secured by a security interest in substantially all of our
assets, other than intellectual property.

In connection with the entry into the Term Loan,  the Company will issue a warrant to SVB, or the Warrant, exercisable
for such number of shares of the Company’s common stock as equal to $87,500 divided by a price per share equal to the average
closing  price  of the  Company’s  common  stock  on the  NASDAQ Capital  Market  for  the  five  trading  days  prior  to the  Funding
Date.  The  Warrant  may  be  exercised  on  a  cashless  basis,  and  is  immediately  exercisable  from  the  Funding  Date  through  the
earlier of (i) the five year anniversary of the Funding Date, or (ii) the consummation of certain acquisition transactions involving
the Company as set forth in the Warrant.

At the closing of the Loan Agreement, SVB earned a commitment fee of $937,500 of which the Company paid $187,500
on  the  closing  date  and  the  remainder  of  which  is  due  and  payable  by  the  Company  in  increments  of  $187,500  on  each
anniversary thereof.
(11) Summary of Quarterly Financial Information (Unaudited)

The  following  tables  set  forth  our  unaudited  quarterly  statements  of  operations  data  in  dollars  and  as  a  percentage  of
revenue and our key metrics for each of the eight quarters ended December 31, 2016. We have prepared the quarterly data on a
consistent  basis  with  the  audited  financial  statements  included  in  this  report.  In  the  opinion  of  management,  the  financial
information reflects all necessary adjustments, consisting only of normal recurring adjustments, necessary for a fair presentation
of  this  data.  This  information  should  be  read  in  conjunction  with  the  audited  financial  statements  and  related  notes  included
elsewhere in this report. The results of historical periods are not necessarily indicative of the results of operations for a full year or
any future period.

2016

Net sales
Gross profit
Net loss
Net loss per share:
       Basic and diluted

2015

Net sales
Gross profit
Net loss
Net loss per share:
       Basic and diluted

Quarter Ended

  March 31

June 30

  September 30  

  December 31  

  $

(in thousands, except share data)

1,471  $
711  
(11,937)  

6,244  $
4,499    
(10,193)    

6,531  $
4,717    
(9,963)    

6,488  
3,927  
(8,073) 

  $

(0.66)  $

(0.56)  $

(0.55)  $

(0.43) 

Quarter Ended

  March 31

June 30

  September 30  

  December 31  

(in thousands, except share data)

  $

12,434  $
9,197    
(3,384)    

14,206  $
10,269    
(2,992)    

9,929  $
6,996    
(6,604)    

1,537  
990  
(28,250) 

  $

(0.23)  $

(0.20)  $

(0.43)  $

(1.57) 

104

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
  
 
  
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
  
 
  
  
 
 
Table of Contents

Sientra, Inc.

Schedule II — Valuation and Qualifying Accounts

December 31, 2016, 2015 and 2014

(In thousands)

Year Ended December 31, 2014
Allowance for sales returns
Year Ended December 31, 2015
Allowance for sales returns
Year Ended December 31, 2016
Allowance for sales returns

(1)

Amounts represent actual sales returns.

Balance at  
  beginning of  
period

Additions  
charged to  
costs and  
expenses

  Deductions 

(1)

Balance at
end of
period

 $

 $

 $

8,270

10,018

660

 $

 $

 $

110,033

85,429

33,797

 $

 $

 $

(108,285)

(94,787)

(30,549)

 $

 $

 $

10,018  

660  

3,908  

105

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
  
 
  
 
  
 
 
  
 
  
 
  
 
  
 
 
  
 
  
 
  
 
  
 
 
 
Table of Contents

Pursuant  to  the  requirements  of  Section  13  or  15(d)  of  the  Securities  Exchange  Act  of  1934,  the  Registrant  has  duly

caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

SIGNATURE S

Date: March 14, 2017

SIENTRA, INC.

By:

/s/ Jeffrey Nugent
Jeffrey Nugent 

Chief Executive Officer

POWER OF ATTORNEY

KNOW  ALL  PERSONS  BY  THESE  PRESENTS,  that  each  person  whose  signature  appears  below  constitutes  and
appoints Jeffrey Nugent and Patrick F. Williams, and each of them, as his true and lawful attorneys‑in‑fact and agents, with full
power of substitution for him, and in his name in any and all capacities, to sign any and all amendments to this Annual Report on
Form 10‑K, and to file the same, with exhibits thereto and other documents in connection therewith, with the U.S. Securities and
Exchange  Commission,  granting  unto  said  attorneys‑in‑fact  and  agents,  and  each  of  them,  full  power  and  authority  to  do  and
perform each and every act and thing requisite and necessary to be done therewith, as fully to all intents and purposes as he or she
might or could do in person, hereby ratifying  and confirming  all that said attorneys‑in‑fact and agents, and either  of them, his
substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, this report has been signed below by

the following persons on behalf of the Registrant and in the capacities and on the dates indicated.

Name

/s/ Jeffrey Nugent
Jeffrey Nugent

Title

Date

Chief Executive Officer and Director (Principal Executive
Officer)

March 14, 2017

/s/ Patrick F. Williams
Patrick F. Williams

Chief Financial Officer and Treasurer (Principal Financial and
Accounting Officer)

March 14, 2017

/s/ Nicholas Simon
Nicholas Simon

/s/ Timothy Haines
Timothy Haines

/s/ R. Scott Greer
R. Scott Greer

/s/ Kevin O’Boyle
Kevin O’Boyle

/s/ Philippe A. Schaison
Philippe A. Schaison

March 14, 2017

March 14, 2017

March 14, 2017

March 14, 2017

March 14, 2017

Director

Director

Director

Director

Director

106

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exhibit 
Number

Exhibit Description

3.1  Amended and Restated

Certificate of Incorporation of
the Registrant

3.2  Amended and Restated Bylaws

of the Registrant.
4.1  Form of Common Stock

Certificate of the Registrant.
4.2  Conversion and Amendment
Agreement by and among the
Registrant and certain of its
stockholders, dated October 10,
2014.

4.3  Amended and Restated Investor
Rights Agreement, dated
March 28, 2012, by and among
Sientra, Inc., and the investors
and stockholders party thereto.

4.4  Warrant to Purchase Stock

issued to Oxford Finance LLC,
dated January 17, 2013.
4.5  Warrant to Purchase Stock

issued to Oxford Finance LLC,
dated January 17, 2013.
4.6  Warrant to Purchase Stock

issued to Oxford Finance LLC,
dated August 1, 2013.
4.7  Warrant to Purchase Stock

issued to Oxford Finance LLC,
dated August 1, 2013.
4.8  Warrant to Purchase Stock

issued to Oxford Finance LLC,
dated December 13, 2013.
4.9  Warrant to Purchase Stock

issued to Oxford Finance LLC,
dated December 13, 2013.

10.1# Form of Indemnity Agreement

by and between Sientra, Inc. and
its directors and officers.
10.2# 2007 Equity Incentive Plan, as
amended, and forms of award
agreements thereunder.
10.3# 2014 Equity Incentive Plan and

forms of award agreements
thereunder.

10.4# 2014 Non‑Employee Director
Compensation Policy.

EXHIBIT INDEX

Incorporated by Reference

Form
S‑1/A

S‑1/A

S‑1/A

S‑1/A

SEC File 
No.
333‑198837

333‑198837

333‑198837

Exhibit
3.2

Filing
October 20, 2014

Filed 
Herewith

3.4

4.1

October 20, 2014

October 20, 2014

333‑198837

4.11

October 20, 2014

S‑1

333‑198837

4.2

September, 19 2014

S‑1

S‑1

S‑1

S‑1

S‑1

S‑1

S‑1

S‑1

333‑198837

333‑198837

333‑198837

333‑198837

333‑198837

333‑198837

4.3

4.4

4.5

4.6

4.7

4.8

September, 19 2014

September, 19 2014

September, 19 2014

September, 19 2014

September, 19 2014

September, 19 2014

333‑198837

10.1

September, 19 2014

333‑198837

10.2

September, 19 2014

S‑1/A

333‑198837

10.3

October 20, 2014

S‑1

333‑198837

10.4

September, 19 2014

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Table of Contents

Exhibit 
Number

Exhibit Description

10.5# 2014 Employee Stock Purchase

Plan.

10.6  Multi‑Purpose Commercial

Building Lease, dated March 28,
2014, by and between
Sientra, Inc. and Fairview
Business Center, L.P.

10.7+ Amended and Restated

Exclusivity Agreement, dated
April 4, 2007, by and between
Sientra, Inc. (formerly, Juliet
Medical, Inc.) and Silimed
Industria de Implantes Ltda.
(formerly, Silimed‑Silicone e
Instrumental Medico‑Cirugio e
Hospitalar Ltda.).

10.8  Amendment No. 1 to Amended
and Restated Exclusivity
Agreement, dated May 12, 2010,
by and between Sientra, Inc.
(formerly, Juliet Medical, Inc.)
and Silimed Industria de
Implantes Ltda. (formerly,
Silimed‑Silicone e Instrumental
Medico‑Cirugio e
Hospitalar Ltda.).

10.9  Amendment No. 2 to Amended
and Restated Exclusivity
Agreement, dated November 8,
2013, by and between
Sientra, Inc. (formerly, Juliet
Medical, Inc.) and Silimed
Industria de Implantes Ltda.
(formerly, Silimed‑Silicone e
Instrumental Medico‑Cirugio e
Hospitalar Ltda.).

10.10# 2014 Employee Stock Purchase

Plan.

10.11# Amended and Restated

Employment Agreement by and
between Sientra, Inc. and
Charles Huiner, dated September
22, 2016.

Incorporated by Reference

Form
S‑1/A

SEC File 
No.
333‑198837

Exhibit
10.5

Filing
October 20, 2014

Filed 
Herewith

S‑1

333‑198837

10.6

September, 19 2014

S‑1/A

333‑198837

10.8

October, 20 2014

S‑1

333‑198837

10.9

September, 19 2014

S‑1

333‑198837

10.10

September, 19 2014

S‑1/A

333‑198837

10-Q

001-36709

10.5

10.1

October 20, 2014

November 9, 2016

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Table of Contents

Exhibit 
Number

Exhibit Description

10.12# Amended and Restated

Employment Agreement by and
between Sientra, Inc. and
Matthew Pigeon, dated
September 22, 2016.
10.13# Separation Agreement by and

between Sientra, Inc. and
Matthew Pigeon, dated
November 7, 2016.

10.14# Employment Agreement by and
between Sientra, Inc. and Patrick
F. Williams, dated October 26,
2016.

10.15# Employment Agreement by and
between Sientra, Inc. and Jeffrey
Nugent, dated November 12,
2015.

10.16# Amendment to Amended and
Restated Employment
Agreement by and between
Sientra, Inc. and Charles Huiner,
dated February 7, 2017.
10.17# Amendment No. 2 to Amended

and Restated Employment
Agreement by and between
Sientra, Inc. and Charles Huiner,
dated March 10, 2017.
10.18# Sientra, Inc. Inducement Plan

and forms of award agreements
thereunder.

21.1  List of significant subsidiaries of

the registrant.

23.1  Consent of KPMG LLP, an

independent registered public
accounting firm.

24.1  Power of Attorney (included in

signature page to this Annual
Report on Form 10‑K).

31.1  Certification of Principal

Executive Officer pursuant to
Rule 13a‑14(a) or
Rule 15d‑14(a) of the Securities
Exchange Act of 1934, as
amended.

Incorporated by Reference

Form
10-Q

SEC File 
No.
001-36709

Exhibit
10.2

Filing
November 9, 2016

Filed 
Herewith

10-Q

001-36709

10.4

November 9, 2016

10-Q

001-36709

10.3

November 9, 2016

10-Q

001-36709

10.3

November 16, 2016

10-K

001-36709

10.20

March 3, 2016

S‑1

333‑198837

21.1

September 19, 2014

X

X

X

X

X

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Table of Contents

Exhibit 
Number

Exhibit Description

Form

Incorporated by Reference

SEC File 
No.

Exhibit

Filing

31.2  Certification of Principal

Financial Officer pursuant to
Rule 13a‑14(a) or
Rule 15d‑14(a) of the Securities
Exchange Act of 1934, as
amended.

32.1  Certification of Principal

32.2  Certification of Principal

Executive Officer pursuant to
Rule 13a‑14(b) of the Securities
Exchange Act of 1934, as
amended, and 18 U.S.C.
Section 1350, as adopted
pursuant to Section 906 of the
Sarbanes‑Oxley Act of 2002.

Financial Officer pursuant to
Rule 13a‑14(b) of the Securities
Exchange Act of 1934, as
amended, and 18 U.S.C.
Section 1350, as adopted
pursuant Section 906 of the
Sarbanes‑Oxley Act of 2002.

101.INS* XBRL Instance Document.
101.SCH* XBRL Taxonomy Extension

Schema Document.

Filed 
Herewith
X

X

X

101.CAL* XBRL Taxonomy Extension

Calculation Linkbase Document.

101.DEF* XBRL Taxonomy Extension

Definition Linkbase Document.

101.LAB* XBRL Taxonomy Extension

Label Linkbase Document.

101.PRE* XBRL Taxonomy Extension

Presentation Linkbase
Document.

+  Confidential  treatment  has  been  granted  with  respect  to  certain  portions  of  this  exhibit.  Omitted  portions  have  been  filed

separately with the SEC.

# Indicates management contract or compensatory plan, contract, or agreement.

*  XBRL  (Extensible  Business  Reporting  Language)  information  is  furnished  and  not  filed  herewith,  is  not  a  part  of  a
registration statement or prospectus for purposes of sections 11 or 12 of the Securities Act of 1933, is deemed

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Table of Contents

not filed for purposes of section 18 of the Securities Exchange Act of 1934, and otherwise is not subject to liability under
these sections. 

 
Amendment To Amended and Restated Employment Agreement

This Amendment (this  “ Amendment ”) to the Amended and Restated Employment Agreement dated September
12,  2016  (the  “  Agreement  ”),  by  and  between  Sientra,  Inc.  and  Charles  Huiner  (the  “  Executive  ”)  is  executed  as  of
February 7, 2017. 

WHEREAS, the Executive and the Company wish to modify various provisions of the Agreement.

NOW,  THEREFORE,  for  good  and  valuable  consideration,  the  adequacy  and  receipt  of  which  is  hereby

acknowledged, the Executive and the Company agree to the following:

Exhibit 10.16

1. Effective January 1, 2017,  the reference to base salary in Section 2.1 of the Agreement is hereby amended to

$350,000.

2. Effective  January  1,  2017,  Section  2.2  of  the  Agreement  is  hereby  amended,  restated  and  replaced  in  its

entirety to read as follows:

2.2  Performance  Bonus.   Executive  will  be  eligible  to  earn  a  performance  bonus  of  up  to
50% of Executive’s Base Salary (the “ Performance Bonus ”) based upon such corporate objectives
and personal performance criteria as are established by the Compensation Committee of the Board of
Directors  (the  “  Committee  ”).    The  achievement  of  and  amount  of  the  Performance  Bonus  as
measured  by  the  foregoing  criteria  shall  be  determined  by  the  Committee  in  its  sole  and  absolute
discretion.    Executive  must  remain  an  active  employee  through  the  end  of  any  given  Performance
Bonus  determination  period.    No  Performance  Bonus  will  be  paid  later  than  March  15  of  the  year
following the year in which the Performance Bonus was earned.

Capitalized terms not defined herein shall have the meanings given to them in the Agreement. In all other respects

the Agreement shall remain in full force and effect.

This  Amendment  constitutes  the  complete,  final  and  exclusive  embodiment  of  the  entire  agreement  between
Executive  and  the  Company  with  regard  to  the  provisions  contained  herein.    This  Amendment  may  not  be  modified  or
amended except in a writing signed by both Executive and a duly authorized officer of the Company.

 
 
 
 
 
 
 
IN WITNESS WHEREOF, the parties have executed this Amendment as of the later of the two dates set forth below.

Company

By:   /s/ Jeffrey M. Nugent

Jeffrey M. Nugent
Printed Name

Chairman and Chief Executive Officer
Title

February 7, 2017
Date

Executive

/s/ Charles Hunier
Charles Huiner

February 7, 2017
Date

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exhibit 10.17

Amendment No. 2 To Amended and Restated Employment Agreement

This  Amendment  No.  2  (this    “  Amendment  ”)  to  the  Amended  and  Restated  Employment  Agreement  dated
September  12,  2016  (the  “  A&R  Employment  Agreement  ”),  as  amended  by  that  certain  Amendment  to  Amended  and
Restated  Employment  Agreement,  dated  as  of  February  7,  2017    (together,  with  the  A&R  Employment  Agreement,  the  “
Agreement ”), by and between Sientra, Inc. and Charles Huiner (the “ Executive ”) is executed as of March 10, 2017. 

WHEREAS, the Executive and the Company wish to modify various provisions of the Agreement.

NOW,  THEREFORE,  for  good  and  valuable  consideration,  the  adequacy  and  receipt  of  which  is  hereby

acknowledged, the Executive and the Company agree to the following:

1.

Section 6.4 of the Agreement is hereby amended such that the following sentence
shall be included following the last sentence of Section 6.4:

“In addition, if an acquiror does not assume or continue Executive’s then unvested Company
equity  awards  in  connection  with  a  Change  in  Control  that  also  represents  a  Corporate
Transaction (as defined in the Company’s 2014 Equity Incentive Plan), then all such awards
shall  accelerate  in  full  and  will  be  deemed  vested  and  exercisable  as  of  the  closing  of  the
Corporate Transaction.”

Capitalized terms not defined herein shall have the meanings given to them in the Agreement. In all other respects

the Agreement shall remain in full force and effect.

This  Amendment  constitutes  the  complete,  final  and  exclusive  embodiment  of  the  entire  agreement  between
Executive  and  the  Company  with  regard  to  the  provisions  contained  herein.    This  Amendment  may  not  be  modified  or
amended except in a writing signed by both Executive and a duly authorized officer of the Company.

 
 
 
 
 
 
 
IN WITNESS WHEREOF, the parties have executed this Amendment as of the later of the two dates set forth below.

Company

By:   /s/ Jeffrey M. Nugent

Jeffrey M. Nugent
Printed Name

Chairman and Chief Executive Officer
Title

March 10, 2017
Date

Executive

/s/ Charles Hunier
Charles Huiner

March 10, 2017
Date

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Consent of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders 
Sientra, Inc.:

We consent to the incorporation by reference in the registration statements (No. 333-199684, 333-202879,
333-209129,    333-210695,  and  333-215603)  on  Form  S-8  of  Sientra,  Inc.  of  our  report  dated  March  14,
2017, with respect to the balance sheets of Sientra, Inc. as of December 31, 2016 and 2015, and the related
statements of operations, convertible preferred stock and stockholders’ equity (deficit), and cash flows for
each  of  the  years  in  the  three-year  period  ended  December  31,  2016,  and  the  related  financial  statement
schedule, which report appears in the December 31, 2016 annual report on Form 10-K of Sientra, Inc.

Los Angeles, California 
March 14, 2017

/s/ KPMG LLP

Exhibit 31.1

 
Exhibit 31.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES‑‑OXLEY ACT OF 2002

I, Jeffrey Nugent, certify that:

1.

I have reviewed this annual report on Form 10‑K of Sientra, Inc.;

2. 

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a
material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not
misleading with respect to the period covered by this report;

3. 

Based on my knowledge, the financial statements, and other financial information included in this report, fairly
present  in all material  respects  the financial  condition, results of operations  and cash flows of the registrant  as of, and for, the
periods presented in this report;

4. 

The  registrant’s  other  certifying  officer  and  I  are  responsible  for  establishing  and  maintaining  disclosure
controls and procedures (as defined in Exchange Act Rules 13a‑15(e) and 15d‑15(e)) and internal control over financial reporting
(as defined in Exchange Act Rules 13(a)-15(f) and 15d-15(f) for the registrant and have:

a. 

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures
to  be  designed  under  our  supervision,  to  ensure  that  material  information  relating  to  the  registrant,  including  its
consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which
this report is being prepared;

b. 

Designed such internal control over financial reporting, or caused such internal control over financial
reporting  to  be  designed  under  our  supervision,  to  provide  reasonable  assurance  regarding  the  reliability  of  financial
reporting  and  the  preparation  of  financial  statements  for  external  purposes  in  accordance  with  generally  accepted
accounting principles;

c. 

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this
report  our  conclusions  about  the  effectiveness  of  the  disclosure  controls  and  procedures,  as  of  the  end  of  the  period
covered by this report based on such evaluation; and

d. 

Disclosed  in  this  report  any  change  in  the  registrant’s  internal  control  over  financial  reporting  that
occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual
report)  that  has  materially  affected,  or  is  reasonably  likely  to  materially  affect,  the  registrant’s  internal  control  over
financial reporting; and

5. 

The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal
control  over  financial  reporting,  to  the  registrant’s  auditors  and  the  audit  committee  of  the  registrant’s  board  of  directors  (or
persons performing the equivalent functions):

a. 

All significant deficiencies and material weaknesses in the design or operation of internal control over
financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize
and report financial information; and

b. 

Any  fraud,  whether  or  not  material,  that  involves  management  or  other  employees  who  have  a

significant role in the registrant’s internal control over financial reporting.

 
Date: March 14, 2017

President and Chief Executive Officer
/s/ Jeffrey Nugent
Jeffrey Nugent 
Chief Executive Officer

Exhibit 31.2

 
 
 
Exhibit 31.2

CERTIFICATION OF CHIEF FINANIAL OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES‑‑OXLEY ACT OF 2002

I, Patrick F. Williams, certify that:

1.

I have reviewed this annual report on Form 10‑K of Sientra, Inc.;

2. 

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a
material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not
misleading with respect to the period covered by this report;

3. 

Based on my knowledge, the financial statements, and other financial information included in this report, fairly
present  in all material  respects  the financial  condition, results of operations  and cash flows of the registrant  as of, and for, the
periods presented in this report;

4. 

The  registrant’s  other  certifying  officer  and  I  are  responsible  for  establishing  and  maintaining  disclosure
controls and procedures (as defined in Exchange Act Rules 13a‑15(e) and 15d‑15(e)) and internal control over financial reporting
(as defined in Exchange Act Rules 13(a)-15(f) and 15d-15(f) for the registrant and have:

a. 

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures
to  be  designed  under  our  supervision,  to  ensure  that  material  information  relating  to  the  registrant,  including  its
consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which
this report is being prepared;

b. 

Designed such internal control over financial reporting, or caused such internal control over financial
reporting  to  be  designed  under  our  supervision,  to  provide  reasonable  assurance  regarding  the  reliability  of  financial
reporting  and  the  preparation  of  financial  statements  for  external  purposes  in  accordance  with  generally  accepted
accounting principles;

c. 

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this
report  our  conclusions  about  the  effectiveness  of  the  disclosure  controls  and  procedures,  as  of  the  end  of  the  period
covered by this report based on such evaluation; and

d. 

Disclosed  in  this  report  any  change  in  the  registrant’s  internal  control  over  financial  reporting  that
occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual
report)  that  has  materially  affected,  or  is  reasonably  likely  to  materially  affect,  the  registrant’s  internal  control  over
financial reporting; and

5. 

The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal
control  over  financial  reporting,  to  the  registrant’s  auditors  and  the  audit  committee  of  the  registrant’s  board  of  directors  (or
persons performing the equivalent functions):

a. 

All significant deficiencies and material weaknesses in the design or operation of internal control over
financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize
and report financial information; and

b. 

Any  fraud,  whether  or  not  material,  that  involves  management  or  other  employees  who  have  a

significant role in the registrant’s internal control over financial reporting.

 
Date: March 14, 2017

Chief Financial Officer
/s/ Patrick F. Williams
Patrick F. Williams 
Chief Financial Officer

Exhibit 32.1

 
 
 
CERTIFICATION OF CHIEF EXECUTIVE OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES‑‑OXLEY ACT OF 2002

Exhibit 32.1

In  connection  with  the  Annual  Report  of  Sientra,  Inc.  (the  “Company”)  on  Form  10‑K  for  the  period  ended
December 31, 2016 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Jeffrey Nugent,
Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes‑Oxley Act of 2002, to my knowledge that:

(1)

(2)

The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of
1934, as amended; and

The  information  contained  in  the  Report  fairly  presents,  in  all  material  respects,  the  financial  condition  and
results of operations of the Company.

Date:  March 14, 2017

President and Chief Executive Officer
/s/ Jeffrey Nugent
Jeffrey Nugent 
Chief Executive Officer

A signed original of this written statement required by Section 906 has been provided to the Company and will be

retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.  The foregoing
certification is being furnished solely pursuant to 18 U.S.C. Section 1350 and is not being filed as part of the Report or as a
separate document.

Exhibit 32.2

 
 
 
CERTIFICATION OF CHIEF FINANCIAL OFFICER

PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES‑‑OXLEY ACT OF 2002

Exhibit 32.2

In  connection  with  the  Annual  Report  of  Sientra,  Inc.  (the  “Company”)  on  Form  10‑K  for  the  period  ended
December  31,  2016  as  filed  with  the  Securities  and  Exchange  Commission  on  the  date  hereof  (the  “Report”),  I,  Patrick  F.
Williams,  Chief  Financial  Officer  of  the  Company,  certify,  pursuant  to  18  U.S.C.  Section  1350,  as  adopted  pursuant  to
Section 906 of the Sarbanes‑Oxley Act of 2002, to my knowledge that:

(1)

(2)

The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of
1934, as amended; and

The  information  contained  in  the  Report  fairly  presents,  in  all  material  respects,  the  financial  condition  and
results of operations of the Company.

Date: March 14, 2017

/s/ Patrick F. Williams
Patrick F. Williams
Chief Financial Officer

A  signed  original  of  this  written  statement  required  by  Section  906  has  been  provided  to  the  Company  and  will  be
retained  by  the  Company  and  furnished  to  the  Securities  and  Exchange  Commission  or  its  staff  upon  request.  The  foregoing
certification  is  being  furnished  solely  pursuant  to  18  U.S.C.  Section  1350  and  is  not  being  filed  as  part  of  the  Report  or  as  a
separate document.