Vanda Pharmaceuticals Inc. Annual Report 2019

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FY2019 Annual Report · Vanda Pharmaceuticals Inc.

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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Form 10-K

☒

☐

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2019

TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF
1934

Commission File No. 001-34186

VANDA PHARMACEUTICALS INC.

(Exact name of registrant as specified in its charter)

Delaware
(State or other jurisdiction of
incorporation or organization)

03-0491827
(I.R.S. Employer
Identification No.)

2200 Pennsylvania Avenue NW, Suite 300 E
Washington DC 20037
(202) 734-3400
(Address and telephone number, including area code, of registrant’s principal executive offices)

Securities registered pursuant to Section 12(b) of the Exchange Act:

Title of each class
Common Stock, par value $0.001 per share

Trading Symbol(s)
VNDA

Name of each exchange on which registered
The Nasdaq Global Market

Securities registered pursuant to Section 12(g) of the Exchange Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act. Yes ☐ No ☒

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of
Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such
files). Yes ☒ No ☐

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best
of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. ☒

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an
emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company”
in Rule 12b-2 of the Exchange Act.

Large accelerated filer

Non-accelerated filer

☒ Accelerated filer

☐ Smaller reporting company

Emerging growth company

☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Securities Exchange Act of 1934). Yes ☐ No ☒

As of June 30, 2019, the last business day of the registrant’s last completed second quarter, the aggregate market value of the Common Stock held by
non-affiliates of the registrant was approximately $731.2 million based on the closing price of the registrant’s Common Stock, as reported by The Nasdaq

Global Market, on such date. Shares of Common Stock held by each executive officer and director and stockholders known by the registrant to own 10% or
more of the outstanding stock based on public filings and other information known to the registrant have been excluded since such persons may be deemed
affiliates. This determination of affiliate status is not necessarily a conclusive determination for other purposes.

The number of shares of the registrant’s Common Stock, par value $0.001 per share, outstanding as of February 18, 2020 was 53,648,617.

The exhibit index as required by Item 601(a) of Regulation S-K is included in Item 15 of Part IV of this report.

DOCUMENTS INCORPORATED BY REFERENCE

Specified portions of the registrant’s proxy statement with respect to the registrant’s 2020 Annual Meeting of Stockholders, which is to be filed pursuant

to Regulation 14A within 120 days after the end of the registrant’s fiscal year ended December 31, 2019, are incorporated by reference into Part III of this
Form 10-K.

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Vanda Pharmaceuticals Inc.
Form 10-K

Table of Contents

Cautionary Note Regarding Forward-Looking Statements

Business

Risk Factors

Unresolved Staff Comments

Properties

Legal Proceedings

Mine Safety Disclosures

Part I

Part II

Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

Selected Consolidated Financial Data

Management’s Discussion and Analysis of Financial Condition and Results of Operations

Item 1

Item 1A

Item 1B

Item 2

Item 3

Item 4

Item 5

Item 6

Item 7

Item 7A

Qualitative and Quantitative Disclosures about Market Risk

Item 8

Item 9

Item 9A

Item 9B

Item 10

Item 11

Item 12

Item 13

Item 14

Financial Statements and Supplementary Data

Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

Controls and Procedures

Other Information

Directors, Executive Officers and Corporate Governance

Executive Compensation

Part III

Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

Certain Relationships and Related Transactions, and Director Independence

Principal Accountant Fees and Services

Part IV

Item 15

Exhibits and Financial Statement Schedules

Signatures

Exhibits

Page

100

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CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

PART I

This annual report on Form 10-K (Annual Report) contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of

1933, as amended (Securities Act) and Section 21E of the Securities Exchange Act of 1934, as amended (Exchange Act). Words such as, but not limited to,
“believe,” “expect,” “anticipate,” “estimate,” “intend,” “plan,” “project,” “target,” “goal,” “likely,” “will,” “would,” and “could,” or the negative of these
terms and similar expressions or words, identify forward-looking statements. Forward-looking statements are based upon current expectations that involve
risks, changes in circumstances, assumptions and uncertainties. The forward-looking statements in this Annual Report may include, among other things,
statements about:

•

the ability of Vanda Pharmaceuticals Inc. (we, our, the Company or Vanda) to continue to commercialize HETLIOZ® (tasimelteon) for the treatment
of Non-24-Hour Sleep-Wake Disorder (Non-24) in the United States (U.S.) and Europe;

our ability to increase market awareness of Non-24 and the market acceptance of HETLIOZ®;

our ability to continue to generate U.S. sales of Fanapt® (iloperidone) for the treatment of schizophrenia;

our dependence on third-party manufacturers to manufacture HETLIOZ® and Fanapt® in sufficient quantities and quality;

our level of success in commercializing HETLIOZ® and Fanapt® in new markets;

our ability to reach agreement with the U.S. Food and Drug Administration (FDA) regarding our regulatory approval strategy, preclinical animal
testing requirements or proposed path to approval for tradipitant;

our ability to prepare, file, prosecute, defend and enforce any patent claims and other intellectual property rights;

our ability to maintain rights to develop and commercialize our products under our license agreements;

our ability to obtain approval from the FDA for HETLIOZ® for the treatment of jet lag disorder;

the ability to obtain and maintain regulatory approval of our products, and the labeling for any approved products;

our expectations regarding the timing and success of preclinical studies and clinical trials;

the ability of our products to be demonstrably safe and effective;

limitations on our ability to utilize some or all of our prior net operating losses and orphan drug and research and development credits;

the size and growth of the potential markets for our products and the ability to serve those markets;

our expectations regarding trends with respect to our revenues, costs, expenses, liabilities and cash, cash equivalents and marketable securities;

the scope, progress, expansion, and costs of developing and commercializing our products;

our ability to identify or obtain rights to new products;

our ability to attract and retain key scientific or management personnel;

the cost and effects of litigation;

our ability to obtain the capital necessary to fund our research and development or commercial activities;

regulatory developments in the U.S., Europe and other jurisdictions;

potential losses incurred from product liability claims made against us; and

the use of our existing cash, cash equivalents and marketable securities.

All written and verbal forward-looking statements attributable to us or any person acting on our behalf are expressly qualified in their entirety by the

cautionary statements contained throughout this report. We caution investors not to rely too heavily on the forward-looking statements we make or that are
made on our behalf. We undertake no obligation, and specifically decline any obligation, to update or revise publicly any forward-looking statements, whether
as a result of new information, future events or otherwise, except as required by law.

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We encourage you to read Management’s Discussion and Analysis of Financial Condition and Results of Operations and our consolidated financial
statements contained in this Annual Report. We also encourage you to read Item 1A of Part I of this Annual Report, entitled Risk Factors, which contains a
more complete discussion of the risks and uncertainties associated with our business. In addition to the risks described in this Annual Report, other unknown
or unpredictable factors also could affect our results. Therefore, the information in this report should be read together with other reports and documents that
we file with the Securities and Exchange Commission from time to time, including on Form 10-Q and Form 8-K, which may supplement, modify, supersede
or update those risk factors. As a result of these factors, we cannot assure you that the forward-looking statements in this report will prove to be accurate.
Furthermore, if our forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these
forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our
objectives and plans in any specified time frame, or at all.

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ITEM 1.

BUSINESS

Overview

Vanda Pharmaceuticals Inc. (we, our, the Company or Vanda) is a leading global biopharmaceutical company focused on the development and

commercialization of innovative therapies to address high unmet medical needs and improve the lives of patients.

We strive to advance novel approaches to bring important, new medicines to market through responsible innovation. We are committed to the use of

technologies that support sound science, including genetics and genomics, in drug discovery, clinical trials and the commercial positioning of our products.

Our commercial portfolio is currently comprised of two products, HETLIOZ® for the treatment of Non-24 and Fanapt® for the treatment of

schizophrenia. HETLIOZ® is the first treatment for Non-24 approved by the FDA. In addition, we have a number of drugs in development, including:

•

HETLIOZ® (tasimelteon) for the treatment of jet lag disorder, Smith-Magenis Syndrome (SMS), pediatric Non-24 and delayed sleep phase disorder
(DSPD);

Fanapt® (iloperidone) for the treatment of bipolar disorder and a long acting injectable (LAI) formulation program for the treatment of
schizophrenia;

Tradipitant (VLY-686), a small molecule neurokinin-1 receptor (NK-1R) antagonist, for the treatment of atopic dermatitis, gastroparesis and motion
sickness;

VTR-297, a small molecule histone deacetylase (HDAC) inhibitor for the treatment of hematologic malignancies and with potential use as a
treatment for several oncology indications;

VQW-765, a small molecule nicotinic acetylcholine receptor partial agonist, with potential use for the treatment of psychiatric disorders; and

Portfolio of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) activators and inhibitors for the treatment of dry eye and ocular
inflammation and for the treatment of secretory diarrhea disorders, including cholera.

We were incorporated in 2003 and are headquartered in Washington, D.C.

Our Strategy

Our goal is to further solidify our position as a leading global biopharmaceutical company focused on developing and commercializing innovative

therapies addressing high unmet medical needs through the application of our drug development expertise and our pharmacogenetics and pharmacogenomics
expertise. The key elements of our strategy to accomplish this goal are to:

• Maximize the commercial success of HETLIOZ® and Fanapt®;

•

Enter into strategic partnerships to supplement our capabilities and to extend our commercial reach;

Pursue the clinical development and regulatory approval of our products, including tradipitant;

Apply our pharmacogenetics and pharmacogenomics expertise to differentiate our products;

Expand our product portfolio through the identification and acquisition of additional products; and

Utilize novel and innovative approaches in pursuit of each of these strategies.

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Commercialized Products

Our commercial product portfolio consists of:

Product

Indication

Non-24

2019 Net Sales (in millions)
$143.0

Geography

United States

Europe

Schizophrenia

$84.2

United States

Israel

HETLIOZ®

In January 2014, HETLIOZ® was approved in the U.S. for the treatment of Non-24 Sleep-Wake Disorder otherwise known as Non-24. Non-24 is a
serious, rare and chronic circadian rhythm sleep-wake disorder characterized by the inability to entrain (synchronize) the master body clock with the 24-hour
day-night cycle. HETLIOZ® is the first FDA approved treatment for Non-24. HETLIOZ® is a melatonin agonist of the human MT1 and MT2 receptors, with
greater specificity for MT2. These receptors are thought to be involved in the control of circadian rhythms. HETLIOZ® is believed to reset the master body
clock in the suprachiasmatic nucleus, located in the hypothalamus, resulting in the entrainment and alignment of the body’s melatonin and cortisol rhythms to
the 24-hour day-night cycle.

Most people have a master body clock that naturally runs longer than 24 hours and light is the primary environmental cue that resets it to 24 hours

each day. Individuals with Non-24 have a master body clock that is not reset, and continually delays, resulting in prolonged periods of misalignment between
their circadian rhythms and the 24-hour day-night cycle, including the timing of melatonin and cortisol secretion. As a result of this misalignment, Non-24 is
associated with significant disruption of the sleep-wake cycle and impairments in social and occupational functioning, and marked subjective distress.
Individuals with Non-24 cycle in and out of phase and suffer from disrupted nighttime sleep patterns and/or excessive daytime sleepiness.

HETLIOZ® was launched commercially in the U.S. in April 2014. In addition, in July 2015, the European Commission (EC) granted centralized

marketing authorization with unified labeling for HETLIOZ® for the treatment of Non-24 in totally blind adults and included post-marketing commitments
related to a pediatric investigation plan. This authorization is valid in the 27 countries that are members of the European Union (E.U.), as well as European
Economic Area members Iceland, Liechtenstein and Norway. HETLIOZ® was launched commercially in Germany in August 2016. We have applied for
renewal of this marketing authorization, which expires in the ordinary course in July 2020.

In January 2010, the FDA granted orphan drug designation status for HETLIOZ® in Non-24 in blind individuals. The FDA grants orphan drug
designation to drugs that may provide significant therapeutic advantage over existing treatments and target conditions affecting 200,000 or fewer U.S. patients
per year. Orphan drug designation provides potential financial and regulatory incentives, including study design assistance, tax credits, waiver of FDA user
fees, and up to seven years of market exclusivity upon marketing approval. In February 2011, the European Medicines Agency (EMA) designated HETLIOZ®
as an orphan medicinal product for the same indication.

Non-24 affects a majority of totally blind individuals, or approximately 80,000 people in the U.S. Blind individuals who develop Non-24 lack the
light sensitivity necessary to synchronize the master body clock in the brain with the 24-hour day-night cycle. More rarely, Non-24 also can affect sighted
individuals. As with the totally blind, Non-24 in sighted individuals appears to be a comorbidity with certain other conditions. For example, a comorbidity has
been established between psychiatric mood disorders and Non-24. Hospitalized individuals with neurological and psychiatric disorders can become
insensitive to social cues, which may predispose them to the development of Non-24. This recognition of comorbidity led Vanda to an initiative to engage
with the psychiatric community. Patients diagnosed with traumatic brain injury, including concussions, frequently suffer from sleep disorders, some of which
may be circadian rhythm sleep-wake disorders, including Non-24.

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While there are no FDA or EC approved treatments for Non-24 other than HETLIOZ®, there are a number of drugs approved and prescribed for

patients with sleep disorders. The most commonly prescribed drugs are hypnotics. See Competition below for a discussion of commonly prescribed drugs for
patients with sleep disorders.

Fanapt®

Fanapt® is a product for the treatment of schizophrenia. In May 2009, the FDA granted U.S. marketing approval of Fanapt® for the acute treatment of

schizophrenia in adults. In October 2009, we entered into an amended and restated sublicense agreement with Novartis. We had originally entered into a
sublicense agreement with Novartis in June 2004 pursuant to which we obtained certain worldwide exclusive licenses from Novartis relating to Fanapt®.
Pursuant to the amended and restated sublicense agreement, Novartis had exclusive commercialization rights to all formulations of Fanapt® in the U.S. and
Canada. In January 2010, Novartis launched Fanapt® in the U.S. On December 31, 2014, Novartis transferred all the U.S. and Canadian commercial rights to
the Fanapt® franchise to us as part of a settlement agreement. Additionally, our distribution partners launched Fanapt® in Israel in 2014. In May 2016, the
FDA approved a supplemental New Drug Application (sNDA) for Fanapt® for the maintenance treatment of schizophrenia in adults.

In July 2017, the EMA’s Committee for Medicinal Products for Human Use (CHMP) issued a negative opinion recommending against approval of

Fanaptum® (oral iloperidone tablets) for the treatment of schizophrenia in adult patients in the E.U. The CHMP was of the opinion that the benefits of
Fanaptum® did not outweigh its risks and recommended against marketing authorization. The negative opinion was upheld upon appeal in November 2017.
(See Part I, Item 3, Legal Proceedings of this Annual Report for information relating to subsequent proceedings in this matter.)

Schizophrenia is a chronic, debilitating mental disorder characterized by hallucinations, delusions, racing thoughts and other psychotic symptoms

(collectively referred to as “positive symptoms”), as well as moodiness, anhedonia (inability to feel pleasure), loss of interest, eating disturbances and
withdrawal (collectively referred to as “negative symptoms”), and attention and memory deficits (collectively referred to as “cognitive symptoms”).
Schizophrenia develops in late adolescence or early adulthood in approximately 1% of the world’s population. Most schizophrenia patients today are treated
with drugs known as “atypical” antipsychotics, which were first approved in the U.S. in the late 1980s. These antipsychotics have been named “atypical” for
their ability to treat a broader range of negative symptoms than the first-generation “typical” antipsychotics, which were introduced in the 1950s and are now
generic. Atypical antipsychotics are generally regarded as having improved side effect profiles and efficacy relative to typical antipsychotics. See Competition
below for a discussion of commonly prescribed atypical antipsychotics in addition to Fanapt®.

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Research and Development

We have the following products in clinical development or under regulatory review:

HETLIOZ® for Jet Lag Disorder

In March and May 2018, respectively, we announced the results of our JET8 and JET studies for the treatment of jet lag disorder. In the JET8 clinical
study, HETLIOZ® demonstrated significant and clinically meaningful benefits in nighttime and daytime symptoms of jet lag disorder, including improvement
in sleep time and benefits in measurements of next day alertness.

The JET study showed effectiveness in treating travelers who traveled either five or eight time zones from Washington, DC to London and San

Francisco or Los Angeles to London, respectively. The results support the previously reported pivotal JET5 and JET8 Phase III studies, which demonstrated
significant effects in circadian advances of five and eight hours, respectively.

Additionally, in September 2018, we announced results from a driving study, which demonstrated that tasimelteon did not impair measures of

driving performance.

The FDA accepted the filing of our sNDA for HETLIOZ® for the treatment of jet lag disorder in December 2018. The FDA determined the action
target date under the Prescription Drug User Fee Act Amendments of 2017 (PDUFA-VI) to be August 16, 2019. Vanda received a complete response letter
(CRL) on August 16, 2019 from the FDA related to the sNDA for HETLIOZ® for the treatment of jet lag disorder, in which the FDA asserted that the
measures demonstrating improved sleep were of unclear clinical significance. We met with the FDA to discuss the CRL in a Post Action meeting and are
continuing to pursue approval of the sNDA.

Jet lag disorder is a common circadian disorder frequently observed in millions of travelers who cross multiple time zones. Jet lag disorder is
characterized by nighttime sleep disruption, a decrease in daytime alertness and impairment to social and occupational functioning. Jet lag disorder symptoms
are more severe during eastward travel. U.S. Department of Commerce, International Trade Administration reports state that more than 20 million U.S.
residents make trips abroad each year to overseas destinations in Europe, the Middle East and Asia.

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HETLIOZ® for SMS

We reported results from an SMS placebo controlled study in December 2018, which showed that HETLIOZ® improved sleep quality and increased
sleep duration in patients with SMS. SMS is a rare genetic disorder caused by a deletion on chromosome 17. The U.S. National Institute of Health estimates
that SMS affects approximately one in 15,000 to 25,000 births in the U.S. We met with the FDA in the fourth quarter of 2019 to discuss the HETLIOZ® SMS
clinical study results. We submitted an sNDA, including data for a liquid formulation, and expect regulatory action by the FDA in 2020.

HETLIOZ® for Pediatric Non-24

We plan to develop HETLIOZ® for the treatment of pediatric Non-24. A pharmacokinetic study of the HETLIOZ® pediatric liquid formulation was

completed in the first quarter of 2018.

HETLIOZ® for DSPD

A clinical program of HETLIOZ® in DSPD is ongoing. DSPD is a circadian rhythm disorder in which a person's sleep is delayed beyond the socially

acceptable or conventional bedtime. This delay in falling asleep causes difficulty in waking up at the desired time and affects social and occupational
functioning.

Fanapt® for Bipolar Disorder (oral tablets)

A Phase III study of Fanapt® in bipolar disorder is ongoing. Bipolar disorders are brain disorders that cause changes in a person’s mood, energy and

ability to function. Bipolar disorder is a category that includes three different conditions - bipolar I, bipolar II and cyclothymic disorder.

People with bipolar disorders have extreme and intense emotional states that occur at distinct times, called mood episodes. These mood episodes are

categorized as manic, hypomanic or depressive. People with bipolar disorders generally have periods of normal mood as well.

Fanapt® LAI

In October 2018, we enrolled our first patient in a pharmacokinetic study of the LAI formulation of Fanapt®. This pharmacokinetic study is ongoing

and will serve to inform the dosing for a later clinical study of Fanapt® LAI for the treatment of schizophrenia.

Tradipitant for Atopic Dermatitis

We announced results in September 2017 from a randomized Phase II clinical study of tradipitant as a monotherapy in the treatment of patients with

atopic dermatitis. Tradipitant was shown to improve the intensity of the worst itch patients experienced, as well as atopic dermatitis disease severity. On the
pre-specified primary endpoint of Average Itch Visual Analog Scale (VAS), tradipitant showed improvement over placebo, but this improvement was not
significant due to high placebo effect and the lack of sensitivity of this measure.

In June 2018, we initiated EPIONE, a Phase III study of tradipitant for pruritus in atopic dermatitis. In October 2019, we began enrolling patients in

EPIONE 2, a second Phase III clinical study of tradipitant in atopic dermatitis. We announced results of EPIONE in February 2020. The EPIONE study did
not meet its primary endpoint in reduction of pruritus across the overall study population. However, the antipruritic effect of tradipitant was robust in the mild
atopic dermatitis population. The EPIONE study continued to demonstrate that tradipitant is safe and well-tolerated. We plan to reassess the ongoing EPIONE
2 study of tradipitant in atopic dermatitis.

Atopic dermatitis is a chronic, relapsing inflammatory skin disorder characterized by the symptom of intense and persistent pruritus or itch. Other

clinical features include erythema, excoriation, edema, lichenification, oozing and xerosis. It is a common skin disorder affecting millions of people
worldwide. Currently, there are very few safe systemic treatments available for atopic dermatitis, representing a significant unmet medical need in this
population. A 2015 Decision Resources Group report estimated that 9.8 million individuals were diagnosed with atopic dermatitis in the U.S., of which
approximately 6.4 million were drug-treated atopic dermatitis patients.

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Tradipitant for Gastroparesis

We announced results in December 2018 from a randomized clinical study (2301) of tradipitant as a monotherapy in the treatment of gastroparesis.

Several symptom severity scales were used to assess gastroparesis symptoms, including the Gastroparesis Symptom Index (GCSI), Patients Assessment of
Upper Gastrointestinal Disorders-Symptoms (PAGI- SYM), and Patient Global Impression of Change (PGI-C) as well as a Clinician Global Impression of
Severity (CGI-S). Tradipitant met the primary endpoint of the study of change in nausea score as measured by patient daily diaries and also met the related
endpoint of improvement in the number of nausea free days. Tradipitant also showed significant improvement in most of the secondary endpoints studied,
including several key scales reflecting overall gastroparesis symptoms, specifically GCSI, PAGI-SYM, CGI-S, and PGI-C.

Gastroparesis is a serious medical condition characterized by delayed gastric emptying associated with the symptoms of nausea, vomiting, bloating,

fullness after meals and abdominal pain, along with significant impairment of social and occupational functioning. A paper by Rey et al published in the
January 2012 Journal of Neurogastroenterology and Motility estimated the prevalence of gastroparesis in the U.S. to be over 5 million patients, many of
whom remain undiagnosed.

In April 2018, we submitted a protocol amendment to the FDA, proposing a 52-week open-label extension (OLE) period for patients who had

completed the tradipitant Phase II clinical study (2301) in gastroparesis. In May 2018, based on feedback from the FDA, we amended the protocol limiting
the duration of treatment in the 2301 study to a total of three months, while continuing to seek further dialogue with the FDA on extending the study duration
to 52-weeks. As a part of this negotiation process, in September 2018, we submitted a new follow-on 52-week OLE protocol to the FDA (2302) for patients
who had completed the 2301 study. While waiting for further feedback, no patients were ever enrolled in any study beyond 12 weeks. On December 19, 2018,
the FDA imposed a partial clinical hold (PCH) on the two proposed studies, stating that we are required first to conduct additional chronic toxicity studies in
canines, monkeys or minipigs before allowing patients access in any clinical protocol beyond 12 weeks. At that time, the FDA informed us that the original
PCH was not based on any safety or efficacy data related to tradipitant, but rather that these additional toxicity studies were required by a guidance document.
Subsequently, the FDA has taken the position that an additional study was required in order for the FDA to have adequate toxicology data to undertake a risk
analysis of tradipitant.

On February 5, 2019, we filed a lawsuit against the FDA in the U.S. District Court for the District of Columbia (DC District Court), challenging the
FDA’s legal authority to issue the PCH, and seeking an order to set it aside. In February 2019, the FDA filed a Motion for Voluntary Remand to the Agency
and for a Stay of the Case. In March 2019, the DC District Court granted the FDA’s request for voluntary remand and returned the matter to the FDA for
further consideration. In April 2019, the FDA provided its remand response, in which it indicated that, upon review of scientific literature and tradipitant data,
it believes that a PCH continues to be appropriate until we have safety data from a nine-month non-rodent toxicity study. In May 2019, we filed an amended
complaint, and in July 2019, we filed a Motion for Summary Judgment based on our continuing belief after review of the FDA’s remand response that
additional chronic toxicity studies are unjustified, and that we have provided the FDA with sufficient information regarding the safety of tradipitant to justify
the continued study of tradipitant in patients beyond 12 weeks, in accordance with applicable law and FDA regulations. The FDA filed a reply and cross-
motion for summary judgment in October 2019 and an oral hearing was held on December 13, 2019. On January 31, 2020, the Court granted the FDA's cross-
motion for summary judgment and granted judgment in favor of the FDA on our claims. We are evaluating our options, including a potential appeal, and we
intend to continue vigorously pursuing our interests in the matter. (see Part I, Item 3, Legal Proceedings of this Annual Report for additional information).

We do not expect the PCH to have a material impact on our ongoing clinical studies in atopic dermatitis, gastroparesis or motion sickness, each of
which is under 12 weeks in duration and are not subject to the PCH. Nor do we expect the PCH to impact the potential timing of the submission of a New
Drug Application (NDA) with the FDA. If the matter has not been fully resolved prior to the date on which we are ready to submit the first NDA for
tradipitant, then we may choose to submit with the safety data we have available at that time. We may pursue additional studies of durations in excess of 12
weeks in countries where the conduct of such studies may be permitted (or we may choose to file for approval of a limited indication). If the FDA continues
to recommend that we conduct a long-term safety study of 12 months duration in humans, and determines that our NDA does not contain safety data
sufficient for approval, it may not accept the NDA for filing. We will continue to reassess the situation on an ongoing basis.

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Enrollment in the Phase III study of tradipitant in gastroparesis is ongoing.

Tradipitant for Motion Sickness

In July 2019, we reported tradipitant was effective in treating motion sickness in a Phase II clinical study conducted in the Pacific Ocean. In the
study, 126 people with a prior history of motion sickness were subjected to sea travel in the Pacific Ocean. Study participants were randomized to receive
either tradipitant or placebo in a blinded fashion. The study had two primary endpoints: percentage of participants vomiting, and Motion Sickness Severity
Scale (MSSS) Worst score. In the overall population, a significantly higher percentage of participants experienced vomiting in the placebo arm as compared
to the tradipitant arm. The MSSS Worst score endpoint also favored tradipitant, but the difference did not reach statistical significance.

Motion sickness is a disorder that arises often as a response to real or perceived movement, as occurring during vehicular travel. Vomiting is the most

disturbing symptom of motion sickness, although the disorder is often accompanied by a constellation of symptoms that includes nausea, sweating, pallor,
headache and anorexia. Motion sickness is one of the most prevalent episodic disorders in the world, whose prevalence has dramatically increased with world
population mobility over the last 100 years. It is reported that approximately 30% of the general population suffers from Motion Sickness under ordinary
travel conditions that include sea, air and land travel.

We plan to complete the Phase III program of tradipitant in motion sickness and expect to file an NDA with the FDA in 2020.

VTR-297

VTR-297 is a small molecule HDAC inhibitor with potential use as a treatment for several oncology indications. The FDA accepted an

Investigational New Drug (IND) application for VTR-297 in 2017 and provided authorization to proceed with the treatment of patients with relapsed and/or
refractory hematologic malignancies. We initiated a clinical study in patients with hematologic malignancies in the fourth quarter of 2018. Enrollment in the
Phase I clinical study (1101) of VTR-297 in hematologic malignancies is ongoing.

Other Products

VQW-765

VQW-765 is a Phase II alpha-7 nicotinic acetylcholine receptor partial agonist that we licensed from Novartis on December 31, 2014 pursuant to a

settlement agreement. The FDA accepted an Investigational New Drug (IND) application for VQW-765 in January 2020 and provided authorization to
proceed with clinical development. We are evaluating VQW-765 for the treatment of psychiatric disorders.

Portfolio of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) activators and inhibitors

An early stage CFTR activator program is planned for the treatment of dry eye and ocular inflammation. In addition, an early stage CFTR inhibitor

program is planned for the treatment of secretory diarrhea disorders, including cholera.

For more detailed information regarding our clinical trial results and regulatory activities for our products please refer to our SEC filings and press

releases, which can be found on the SEC Edgar system and on our website www.vandapharma.com.

License Agreements

Our rights to develop and commercialize our products are subject to the terms and conditions of licenses granted to us by other pharmaceutical

companies.

HETLIOZ®

In February 2004, we entered into a license agreement with Bristol-Myers Squibb (BMS) under which we received an exclusive worldwide license

under certain patents and patent applications, and other licenses to intellectual property, to develop and commercialize HETLIOZ®. To date, we have paid
BMS $37.5 million in upfront fees and milestone obligations. We have no remaining milestone obligations to BMS. Additionally, we are obligated to make
royalty payments on HETLIOZ® net sales to BMS in any territory where we commercialize HETLIOZ® for a period equal to the greater of 10 years
following the first

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commercial sale in the territory or the expiry of the new chemical entity (NCE) patent in that territory. During the period prior to the expiry of the NCE patent
in a territory, we are obligated to pay a 10% royalty on net sales in that territory. The royalty rate is decreased by half for countries in which no NCE patent
existed or for the remainder of the 10 years after the expiry of the NCE patent. We are also obligated under the license agreement to pay BMS a percentage of
any sublicense fees, upfront payments and milestone and other payments (excluding royalties) that we receive from a third-party in connection with any
sublicensing arrangement, at a rate which is in the mid-twenties. We have agreed with BMS in the license agreement for HETLIOZ® to use commercially
reasonable efforts to develop and commercialize HETLIOZ®.

Either party may terminate the HETLIOZ® license agreement under certain circumstances, including a material breach of the agreement by the other.

In the event we terminate our license, or if BMS terminates our license due to our breach, all rights licensed and developed by us under this agreement will
revert or otherwise be licensed back to BMS on an exclusive basis.

Fanapt®

Pursuant to the terms of a settlement agreement with Novartis, Novartis transferred all U.S. and Canadian rights in the Fanapt® franchise to us on

December 31, 2014. We paid directly to Sanofi S.A. (Sanofi) a fixed royalty of 3% of net sales through December 2019 related to manufacturing know-
how. No further royalties on manufacturing know-how are payable by us. We are also obligated to pay Sanofi a fixed royalty on Fanapt® net sales equal up to
6% on Sanofi know-how not related to manufacturing under certain conditions for a period of up to 10 years in markets where the NCE patent has expired or
was not issued. We are obligated to pay this 6% royalty on net sales in the U.S. through November 2026. No further royalties on know-how not related to
manufacturing will be payable by us for net sales in the U.S. after November 2026. We may lose our rights to develop and commercialize Fanapt® if we fail to
comply with certain requirements in the Titan license agreement regarding our financial condition, or if we fail to comply with certain diligence obligations
regarding our development or commercialization activities.

Tradipitant (VLY-686)

In April 2012, we entered into a license agreement with Eli Lilly and Company (Lilly) pursuant to which we acquired an exclusive worldwide

license under certain patents and patent applications, and other licenses to intellectual property, to develop and commercialize an NK-1R antagonist,
tradipitant, for all human indications. Lilly is eligible to receive future payments based upon achievement of specified development, regulatory approval and
commercialization milestones as well as tiered-royalties on net sales at percentage rates up to the low double digits. To date, we have paid Lilly $3.0 million
in upfront fees and development milestones, including a $2.0 million milestone payment as a result of enrolling the first subject into a Phase III study for
tradipitant in July 2018. As of December 31, 2019, remaining milestones include a $2.0 million development milestone due upon the filing of the first
marketing authorization for tradipitant in either the U.S. or the E.U, $10.0 million and $5.0 million for the first approval of a marketing authorization for
tradipitant in the U.S. and E.U., respectively, and up to $80.0 million for sales milestones. We are obligated to use commercially reasonable efforts to develop
and commercialize tradipitant.

Either party may terminate the agreement under certain circumstances, including a material breach of the agreement by the other. In the event that we

terminate the agreement, or if Lilly terminates the agreement due to our breach or for certain other reasons set forth in the agreement, all rights licensed and
developed by us under the agreement will revert or otherwise be licensed back to Lilly on an exclusive basis, subject to payment by Lilly to us of a royalty on
net sales of products that contain tradipitant.

VQW-765

In connection with the settlement agreement with Novartis relating to Fanapt®, we received an exclusive worldwide license under certain patents and

patent applications, and other licenses to intellectual property, to develop and commercialize VQW-765, a Phase II alpha-7 nicotinic acetylcholine receptor
partial agonist. Pursuant to the license agreement, we are obligated to use commercially reasonable efforts to develop and commercialize VQW-765 and are
responsible for all development costs. We have no milestone obligations, but Novartis is eligible to receive tiered-royalties on net sales at percentage rates up
to the mid-teens.

Either party may terminate the agreement under certain circumstances, including a material breach of the agreement by the other. In the event that we

terminate the agreement, or if Novartis terminates the agreement due to our breach or for certain other reasons set forth in the agreement, all rights licensed
and developed by us under the agreement will revert or

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otherwise be licensed back to Novartis on an exclusive basis, subject to payment by Novartis to us of a royalty on net sales of products that contain VQW-
765.

Portfolio of CFTR activators and inhibitors

In March 2017, we entered into a license agreement with the University of California San Francisco (UCSF), under which we acquired an exclusive

worldwide license to develop and commercialize a portfolio of CFTR activators and inhibitors. Pursuant to the license agreement, we will develop and
commercialize the CFTR activators and inhibitors and are responsible for all development costs under the license agreement, including current pre-
investigational new drug development work. UCSF is eligible to receive future payments based upon achievement of specified development, regulatory
approval and commercialization milestones as well as single-digit tiered-royalties on net sales. To date, we have paid UCSF $1.2 million in upfront fees and
development milestones, including an upfront license fee payment of $1.0 million in 2017 and a $0.2 million development milestone payment in March 2019.
As of December 31, 2019, remaining milestones include $12.2 million for development milestones and $33.0 million for future regulatory approval and sales
milestones. Included in the $12.2 million in development milestones is a $350,000 milestone due upon the conclusion of a Phase I study for each licensed
product but not to exceed $1.1 million in total for the CFTR portfolio.

Either party may terminate the agreement under certain circumstances. In the event that we terminate the agreement, or if UCSF terminates the

agreement due to our breach or for certain other reasons set forth in the agreement, all rights licensed and developed by us under the agreement will revert or
otherwise be licensed back to UCSF. Termination will not relieve us of our obligation to pay royalties or other payments owed, if any, to UCSF under the
terms of the agreement.

Patents and proprietary rights; Hatch-Waxman protection

We will be able to protect our products from unauthorized use by others only to the extent that our products are covered through regulatory
protections or by valid and enforceable patents, either licensed to us by others or generated through our activities internally, that give us sufficient proprietary
rights. Accordingly, securing patents, regulatory data package protection, and other proprietary rights is an essential element of our business strategies.

HETLIOZ®, tradipitant and VQW-765 are covered by NCE and other patents and patent applications related to their respective medicinal uses. In
addition, NCE patent protection has been sought for VTR-297 and CFTR. Patent applications for these active ingredients remain pending. While the NCE
patents protecting Fanapt® have expired, Fanapt® remains protected by medicinal patents. For more on the license and sublicense arrangements related to
these active ingredients, see License Agreements above. In addition, we have filed for patents based on our own discoveries that seek to provide additional
protection for HETLIOZ® and Fanapt®.

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The table below is a summary of patents listed in the Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) for our

commercial products. Members of these patent families are also issued or pending in a number of territories, such as Europe and Japan.

Product

HETLIOZ®

Fanapt®

HETLIOZ®

Number
US 5,856,529

US 9,060,995

US 9,539,234

US 9,549,913

US 9,730,910

US 9,855,241

US RE46604

US 10,071,977

US 10,149,829

US 10,376,487

US 10,449,176

US 8,586,610

US 8,652,776

US 8,999,638

US 9,072,742

US 9,074,254

US 9,074,255

US 9,074,256

US 9,138,432

US 9,157,121

Type
New chemical entity

Method of treatment

Drug substance

Method of treatment

Our rights to the NCE patent covering HETLIOZ® and related intellectual property have been acquired through a license with BMS. HETLIOZ® and

its formulations, genetic markers and uses are the subject of numerous patent filings for which protection has been sought in selected countries worldwide.
The NCE patent covering HETLIOZ® expires in December 2022 in the U.S., which is inclusive of a five-year extension granted under the Hatch-Waxman Act
in October 2018. Corresponding NCE patent protection has expired in most other markets. The U.S. Patent and Trademark Office has issued nine method of
use patents for HETLIOZ® that will expire between 2033 and 2035 and one drug substance patent that will expire in 2035.

In Europe, the law provides for ten years of data exclusivity (with the potential for an additional year if a medicine is developed for a significant new

indication). In addition, Europe provides for ten years of market exclusivity for orphan indications. As such, in Europe, data or market exclusivity will
provide protection for HETLIOZ® for at least ten years from approval. It is also possible that the protection through a basic patent (i.e., a patent which
protects a product as such, a process to obtain a product, or an application of a product) in Europe could be extended for up to five years by the issuance of a
supplementary protection certificate (SPC). A completed Pediatric Investigation Plan (PIP) could further extend SPC protection for an additional six months
or the market exclusivity in an orphan indication for two additional years. Thus, a PIP could provide a total of 12 years of market exclusivity for an orphan
indication. The European Patent Office has granted our patent application directed to the 20 mg/day dose. This patent will expire in 2027 and provides the
basis for an SPC. Other pending patent applications in Europe, if granted, may offer additional protection for HETLIOZ®.

Outside the U.S. and Europe, data exclusivity will protect HETLIOZ® from generic competition for varying numbers of years depending on the

country.

Additional patent applications directed to specific sleep disorders and to methods of treating patients with HETLIOZ®, if issued, would provide

exclusivity for such indications and methods of treatment, potentially extending the effective patent protection period in the U.S., Europe, and other markets.

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Fanapt®

The NCE patent for Fanapt®, which expired in 2016 in the U.S. and in 2010 in other countries, was owned by Sanofi. Other patents and patent

applications relating to Fanapt® are owned by Vanda.

Fanapt® metabolites, formulations, genetic markers and uses are the subject of numerous patent filings in which protection has been sought in the

U.S., Europe, and other markets. In November 2013, a U.S. patent (U.S. 8,586,610) directed to a method of treating patients with Fanapt® based on genotype
was issued to us by the U.S. Patent and Trademark Office. This patent, which was listed in the Orange Book in January 2015, is set to expire in 2027,
potentially further extending the U.S. marketing exclusivity for Fanapt®. Additional method of treatment patents have been issued in the U.S. and listed in the
Orange Book, with the latest expiration date in December 2031.

We have also filed and plan on filing additional patent applications covering the use of iloperidone (Fanapt® active ingredient) LAI formulations.

Patents for the microsphere LAI formulation of Fanapt® expire in 2024 in the U.S. and 2022 in some markets in Europe. Patents for the aqueous microcrystals
LAI formulation of Fanapt® expire in 2023 in the U.S. and in some markets in Europe. We have pending patent applications covering the use of iloperidone
and plan on filing additional applications based on discoveries made throughout the development plan of this molecule.

In Europe, the law provides for ten years of regulatory exclusivity (with the potential for an additional year if the drug is developed for a significant

new indication). No generic versions of Fanapt® would be permitted to be marketed or sold during the applicable regulatory exclusivity period in most
European countries. Outside the U.S. and Europe, similar regulatory package protection periods may be available and could protect Fanapt® from generic
competition for varying numbers of years depending upon the country.

Tradipitant

Lilly owns an NCE patent as well as patent applications directed to polymorphic forms of, and methods of making tradipitant. This patent protection
was sought in the U.S. and in other countries worldwide. These patents and patent applications have been licensed to us. The NCE patent covering tradipitant
expires in April 2023, except in the U.S., where it expires normally in June 2024, subject to any extension that may be received under Hatch-Waxman. We
have filed additional patent applications based on discoveries made during recent studies with tradipitant.

VTR-297

VTR-297 is a small molecule HDAC inhibitor with potential use as a treatment for several oncology indications. We have pending patent

applications covering the use of VTR-297 and plan on filing additional applications based on discoveries made throughout the development plan of this
molecule.

VQW-765

Novartis owns an NCE patent as well as patent applications directed to methods of using VQW-765, VQW-765 formulations, and combinations of

VQW-765 with other active pharmaceutical ingredients. In connection with the settlement agreement with Novartis relating to Fanapt®, we received an
exclusive worldwide license under certain patents and patent applications, and other licenses to intellectual property, to develop and commercialize VQW-
765, a Phase II alpha-7 nicotinic acetylcholine receptor partial agonist. The NCE patent expires normally in 2023 in the U.S., Europe, and other markets.

Portfolio of CFTR activators and inhibitors

Our portfolio of CFTR activators and inhibitors may have broad applicability in addressing a number of high unmet medical needs, including
chronic dry eye, constipation, polycystic kidney disease, cholestasis and secretory diarrheas. We plan on filing applications based on discoveries made
throughout the development plan of these compounds.

Other Patents

Aside from the NCE patents and other in-licensed patents discussed above, we have obtained or filed numerous patents and patent applications, most

of which have been filed in key markets including the U.S., relating to our products and development compounds. In addition, we have filed numerous other
patent applications relating to drugs not presently in clinical studies. The claims in these various patents and patent applications are directed to compositions
of matter, including claims covering other products, pharmaceutical compositions and methods of use.

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Proprietary Know-how

For proprietary know-how that is not appropriate for patent protection, processes for which patents are difficult to enforce and any other elements of

our discovery process that involve proprietary know-how and technology that are not covered by patent applications, we generally rely on trade secret
protection and confidentiality agreements to protect our interests. We require all of our employees, relevant consultants and advisors to enter into
confidentiality agreements. Where it is necessary to share our proprietary information or data with outside parties, our policy is to make available only that
information and data required to accomplish the desired purpose and only pursuant to a duty of confidentiality on the part of those parties.

Marketing and Sales

HETLIOZ® was approved in the U.S. for the treatment of Non-24 in January 2014 and commercially launched in the U.S. in April 2014.

Additionally, HETLIOZ® was approved in the E.U. for the treatment of Non-24 in totally blind adults in July 2015. We commercially launched HETLIOZ® in
Germany in August 2016. Given the range of potential indications for HETLIOZ®, we may pursue one or more partnerships for the development and
commercialization of HETLIOZ® worldwide.

Fanapt® was approved in the U.S. for the treatment of schizophrenia in May 2009 and commercially launched in the U.S. in January 2010. We

continue to explore the regulatory path and commercial opportunity for Fanapt® oral formulation in other regions.

Manufacturing

We currently utilize a virtual supply manufacturing and distribution chain in which we do not have our own facilities to manufacture commercial or
clinical trial supplies of drugs and we do not have our own distribution facilities. Additionally, we do not intend to develop such facilities for any product in
the near future. Instead, we contract with third parties for the manufacture, warehousing, order management, billing and collection and distribution of our
products and product candidates.

We expect to continue to rely solely on third-party manufacturers to manufacture drug substance and final drug products for both clinical
development and commercial sale. However, there are numerous factors that could cause interruptions in the supply of our products, including regulatory
reviews, changes in our sources for manufacturing, disputes with a manufacturer, or financial instability of manufacturers, all of which could negatively
impact our operation and our financial results.

We have agreements in place with Patheon Pharmaceuticals Inc. and Patheon Inc. (collectively, Patheon), subsidiaries of Thermo Fisher Scientific,

for the manufacture of HETLIOZ® and Fanapt®.

In January 2014, we entered into a manufacturing agreement with Patheon for the manufacture of commercial supplies of HETLIOZ® 20 mg

capsules at Patheon’s Cincinnati, Ohio manufacturing site. Under the HETLIOZ® manufacturing agreement, we are responsible for supplying the active
pharmaceutical ingredient (tasimelteon) for HETLIOZ® to Patheon and have agreed to order from Patheon at least 80% of the total expected yearly
production of new units of HETLIOZ® capsules. Patheon is responsible for manufacturing the HETLIOZ® 20 mg capsules, conducting quality control and
stability testing, and packaging the HETLIOZ® capsules. The HETLIOZ® manufacturing agreement had an initial term of five years and automatically renews
after the initial term for successive terms of one year each, unless either party gives notice of its intention to terminate the agreement at least 12 months prior
to the end of the then current term. Either party may terminate the HETLIOZ® manufacturing agreement under certain circumstances upon specified written
notice to the other party.

As part of a settlement agreement in 2014, we assumed Novartis’ manufacturing agreement with Patheon for the manufacture of commercial
supplies of Fanapt®. In May 2016, we entered into a new manufacturing agreement with Patheon for the manufacture of commercial supplies of Fanapt® 1, 2,
4, 6, 8, 10 and 12 mg tablets at Patheon’s Mississauga, Ontario, Canada manufacturing site. Under the Fanapt® manufacturing agreement, we are responsible
for sourcing the supply of the active pharmaceutical ingredient (iloperidone), and have agreed to order from Patheon at least 70% of the total expected yearly
production of new units of Fanapt® tablets for the U.S. and other specified countries each year for the term of the agreement. Patheon is responsible for
manufacturing the Fanapt® 1, 2, 4, 6, 8, 10 and 12 mg tablets, conducting quality control and stability testing, and packaging the Fanapt® tablets. The Fanapt®
manufacturing agreement has an initial term of five years and will automatically renew after the initial term for successive terms of one year each, unless
either party gives notice of its intention to terminate the agreement at least 12 months prior to the end of the then current term. Either party may terminate the
Fanapt® manufacturing agreement under certain circumstances upon specified written notice to the other party.

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Research and Development

We have built a research and development organization that includes extensive expertise in the scientific disciplines of pharmacogenetics and
pharmacogenomics. We operate cross-functionally and are led by an experienced research and development management team. We use rigorous project
management techniques to assist us in making disciplined strategic research and development program decisions and to help limit the risk profile of our
product pipeline. We also access relevant market information and key opinion leaders in creating target product profiles and, when appropriate, as we advance
our programs towards commercialization. We engage third parties to conduct portions of our preclinical research. In addition, we utilize multiple clinical sites
to conduct our clinical trials; however, we are not substantially dependent upon any one of these sites for our clinical trials nor do any of them conduct a
major portion of our clinical trials.

Major Customers

Our revenues are generated from product sales and are concentrated with specialty pharmacies, including Diplomat Pharmacy, Inc. (a subsidiary of

UnitedHealth Group) and Accredo (a subsidiary of Express Scripts), and wholesalers, including Cardinal Health, Inc., AmerisourceBergen Drug Corporation,
and McKesson Corporation. These 5 major customers each accounted for more than 10% of total revenues and, as a group, represented 96% of total revenues
for the year ended December 31, 2019.

Competition

The pharmaceutical industry, in particular, is highly competitive and includes a number of established large and mid-sized companies with greater

financial, technical and personnel resources than we have and significantly greater commercial infrastructures than we have. Our market segment also
includes several smaller emerging companies whose activities are directly focused on our target markets and areas of expertise. Our products, once approved
for commercial use, will compete with numerous therapeutic treatments offered by these competitors. While we believe that our products will have certain
favorable features, existing and new treatments may also possess advantages. Additionally, the development of other drug technologies and methods of
disease prevention are occurring at a rapid pace. These developments may render our products or technologies obsolete or noncompetitive.

We believe the primary competitors for HETLIOZ® and Fanapt® are as follows:

•

For HETLIOZ® in the treatment of Non-24, there are no FDA approved direct competitors. Sedative-Hypnotic treatments for certain sleep
related disorders include, Ambien® (zolpidem) by Sanofi (including Ambien CR®), Lunesta® (eszopiclone) by Sunovion Pharmaceuticals Inc.,
Sonata® (zaleplon) by Pfizer Inc., Rozerem® (ramelteon) by Takeda Pharmaceuticals Company Limited, Silenor® (doxepin) by Pernix
Therapeutics, Belsomra® (suvorexant) by Merck & Co., Inc., generic products such as zolpidem, trazodone and doxepin, and over-the-counter
remedies such as Benadryl® and Tylenol PM®. The class of melatonin agonists includes Rozerem® (ramelteon) by Takeda Pharmaceuticals
Company Limited, Valdoxan® (agomelatine) by Servier, Circadin® (long-acting melatonin) by Neurim Pharmaceuticals Ltd. and the food
supplement melatonin. Shift work and excessive sleepiness disorder treatments include Nuvigil® (armodafinil) and Provigil® (modafinil) both by
Teva Pharmaceutical Industries Ltd.

For Fanapt® in the treatment of schizophrenia, the atypical antipsychotics competitors are Risperdal® (risperidone), including the LAI
formulation Risperdal Consta® and Invega® (paliperidone), including the LAI formulation Invega® Sustenna®, each by Ortho-McNeil-Janssen
Pharmaceuticals, Inc., Zyprexa® (olanzapine), including the LAI formulation Zyprexa® RelprevvTM, each by Lilly, Seroquel® and Seroquel XR®
(quetiapine) by AstraZeneca PLC, Abilify® (aripiprazole) by Otsuka America Pharmaceutical Inc., Abilify Maintena® (the LAI formulation of
Abilify®) by Lundbeck/Otsuka America Pharmaceutical Inc., Geodon® (ziprasidone) by Pfizer Inc., Saphris® (asenapine) by Allergan plc,
Latuda® (lurasidone) by Sunovion Pharmaceuticals Inc., Rexulti® (brexpiprazole) by Lundbeck/Otsuka America Pharmaceutical, Inc.,
AristadaTM (aripiprazole lauroxil) extended-release injectable suspension by Alkermes, Inc., VraylarTM (cariprazine) by Teva Pharmaceutical
Industries Ltd., CALYPTA® (lumapteperone) by Intra-Cellular Therapies, and generic clozapine, as well as the typical antipsychotics
haloperidol, chlorpromazine, thioridazine, and sulpiride (all of which are generic).

Our ability to compete successfully will depend in part on our ability to utilize our pharmacogenetics and pharmacogenomics and drug development

expertise to identify, develop, secure rights to and obtain regulatory approvals for promising pharmaceutical products before others are able to develop
competitive products. Our ability to compete successfully will also depend on our ability to attract and retain skilled and experienced personnel. Additionally,
our ability to compete may

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be affected because insurers and other third-party payors in some cases seek to encourage the use of cheaper, generic products, which could make our
products less attractive.

Government Regulation

United States government regulation

Exclusivity

The FDA provides periods of regulatory exclusivity, which provides the holder of an approved NDA limited protection from new competition in the

marketplace for the innovation represented by its approved drug for a period of three or five years following the FDA’s approval of the NDA. Five years of
exclusivity are available to NCEs. An NCE is a drug that contains no active moiety that has been approved by the FDA in any other NDA. An active moiety
is the molecule or ion, excluding those appended portions of the molecule that cause the drug to be an ester, salt, including a salt with hydrogen or
coordination bonds, or other noncovalent, or not involving the sharing of electron pairs between atoms, derivatives, such as a complex (i.e., formed by the
chemical interaction of two compounds), chelate (i.e., a chemical compound), or clathrate (i.e., a polymer framework that traps molecules), of the molecule,
responsible for the therapeutic activity of the drug substance. During the exclusivity period, the FDA may not accept for review or approve an abbreviated
new drug application (ANDA) or a 505(b)(2) NDA submitted by another company that contains the previously approved active moiety. An ANDA or 505(b)
(2) application, however, may be submitted one year before NCE exclusivity expires if a Paragraph IV certification is filed. If a product is not eligible for the
NCE exclusivity, it may be eligible for three years of exclusivity. Three-year exclusivity is available to the holder of an NDA, including a 505(b)(2) NDA, for
a particular condition of approval, or change to a marketed product, such as a new formulation for a previously approved product, if one or more new clinical
trials, other than bioavailability or bioequivalence trials, was essential to the approval of the application and was conducted or sponsored by the applicant.
This three-year exclusivity period protects against FDA approval of ANDAs and 505(b)(2) NDAs for the condition of the new drug’s approval. As a general
matter, three-year exclusivity does not prohibit the FDA from approving ANDAs or 505(b)(2) NDAs for generic versions of the original, unmodified drug
product. Five-year and three-year exclusivity will not delay the submission or approval of a full NDA; however, an applicant submitting a full NDA would be
required to conduct or obtain a right of reference to all of the preclinical studies and adequate and well-controlled clinical trials necessary to demonstrate
safety and efficacy.

Orphan Drug Act

Under the Orphan Drug Act, the FDA may grant Orphan Drug Designation to drugs intended to treat a rare disease or condition, generally a disease

or condition that affects fewer than 200,000 individuals in the U.S. Orphan Drug Designation must be requested before submitting an NDA. After the FDA
grants Orphan Drug Designation, the generic identity of the drug and its potential orphan use are disclosed publicly by the FDA. Orphan Drug Designation
does not convey any advantage in, or shorten the duration of, the regulatory review and approval process. The first NDA applicant to receive FDA approval
for a particular active ingredient to treat a particular disease with FDA Orphan Drug Designation is entitled to a seven-year exclusive marketing period in the
United States for that product, for that indication. During the seven-year exclusivity period, the FDA may not approve any other applications to market the
same drug for the same disease, except in limited circumstances, such as a showing of clinical superiority to the product with orphan drug exclusivity. Orphan
drug exclusivity does not prevent FDA from approving a different drug for the same disease or condition, or the same drug for a different disease or
condition. Among the other benefits of Orphan Drug Designation are tax credits for certain research and development expenses and a waiver of the NDA
application user fee.

Fast Track and Breakthrough Therapy Designations

The FDA is required to facilitate the development and expedite the review of drugs that are intended for the treatment of a serious or life-threatening

condition for which there is no effective treatment, and which demonstrate the potential to address unmet medical needs for the condition. Under the Fast
Track program, the sponsor of a new product candidate may request the FDA to designate the product for a specific indication as a Fast Track product
concurrent with or after the submission of the IND for the product candidate. The FDA must determine if the product candidate qualifies for Fast Track and
Breakthrough Therapy designations within 60 days after receipt of the sponsor’s request. For Fast Track and Breakthrough Therapy products, the sponsor
may have more frequent interactions with the FDA and the FDA may initiate review of sections of a Fast Track or Breakthrough Therapy product’s NDA
before the application is complete. This rolling review is available if the applicant provides and the FDA approves a schedule for the submission of the
remaining information and the applicant pays applicable user fees. However, the FDA’s time period goal for reviewing a Fast Track or Breakthrough Therapy
application does not begin until the last section of the NDA is submitted. In addition, the Fast Track and Breakthrough Therapy designations may be
withdrawn by the FDA if the FDA believes that the designation is no longer supported by data emerging in

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the clinical trial process. A Fast Track and Breakthrough Therapy designated product candidate would ordinarily meet the FDA’s criteria for priority review.

NDA Submission and Review by the FDA

Assuming successful completion of the required clinical trials and preclinical testing, among other items, the results of product development,

including chemistry, manufacture and controls, nonclinical studies and clinical trials are submitted to the FDA, along with proposed labeling, as part of an
NDA. The submission of an NDA requires payment of a substantial user fee to the FDA. These user fees must be paid at the time of the first submission of
the application, even if the application is being submitted on a rolling basis. Fee waivers or reductions are available in some circumstances. One basis for a
waiver of the application user fee is if the applicant employs fewer than 500 employees, including employees of affiliates, the applicant does not have an
approved marketing application for a product that has been introduced or delivered for introduction into interstate commerce, and the applicant, including its
affiliates, is submitting its first marketing application.

In addition, under the Pediatric Research Equity Act (PREA), an NDA or supplement to an NDA for a new active ingredient, indication, dosage

form, dosage regimen or route of administration must contain data that are adequate to assess the safety and efficacy of the drug for the claimed indications in
all relevant pediatric subpopulations, and to support dosing and administration for each pediatric subpopulation for which the product is safe and effective.
The FDA may, on its own initiative or at the request of the applicant, grant deferrals for submission of some or all pediatric data until after approval of the
product for use in adults or full or partial waivers from the pediatric data requirements.

The FDA may refer applications for drugs that contain active ingredients, including any ester or salt of the active ingredients that have not previously
been approved by the FDA to an advisory committee or provide in an action letter a summary of the reasons for not referring it to an advisory committee. The
FDA may also refer drugs which present difficult questions of safety, purity or potency to an advisory committee. An advisory committee is typically a panel
that includes clinicians and other experts who review, evaluate and make a recommendation as to whether the application should be approved and under what
conditions. The FDA is not bound by the recommendations of an advisory committee, but it considers such recommendations carefully when making
decisions.

The FDA reviews applications to determine, among other things, whether a product is safe and effective for its intended use and whether the

manufacturing controls are adequate to assure and preserve the product’s identity, strength, quality and purity. Before approving an NDA, the FDA will
inspect the facility or facilities where the product is manufactured. The FDA will not approve an application unless it determines that the manufacturing
processes and facilities, including contract manufacturers and subcontracts, are in compliance with current Good Manufacturing Practices (cGMP)
requirements and adequate to assure consistent production of the product within required specifications. Additionally, before approving an NDA, the FDA
will typically inspect one or more clinical trial sites to assure compliance with Good Clinical Practices (GCPs).

Once the FDA receives an application, it has 60 days to review the NDA to determine if it is substantially complete to permit a substantive review,

before it accepts the application for filing. Once the submission is accepted for filing, the FDA begins an in-depth review of the NDA. The FDA’s NDA
review times may differ based on whether the application is a standard review or priority review application. The FDA may give a priority review designation
to drugs that are intended to treat serious conditions and provide significant improvements in the safety or effectiveness of the treatment, diagnosis, or
prevention of serious conditions. Under the goals and policies agreed to by the FDA under the Prescription Drug User Fee Act (PDUFA), the FDA has set the
review goal of 10 months from the 60-day filing date to complete its initial review of a standard NDA for a new molecular entity (NME) and make a decision
on the application. For non-NME standard applications, the FDA has set the review goal of 10 months from the submission date to complete its initial review
and to make a decision on the application. For priority review applications, the FDA has set the review goal of reviewing NME NDAs within six months of
the 60-day filing date and non-NME applications within six months of the submission date. Such deadlines are referred to as the PDUFA date. The PDUFA
date is only a goal and the FDA does not always meet its PDUFA dates. The review process and the PDUFA date may also be extended if the FDA requests or
the NDA sponsor otherwise provides additional information or clarification regarding the submission.

Once the FDA’s review of the application is complete, the FDA will issue either a Complete Response Letter, or CRL, or approval letter. A CRL

indicates that the review cycle of the application is complete, and the application is not ready for approval. A CRL generally contains a statement of specific
conditions that must be met in order to secure final approval of the NDA and may require additional clinical or preclinical testing, or other information or
analyses in order for the FDA to reconsider the application. The FDA has the goal of reviewing 90% of application resubmissions in either two or six months
of the resubmission date, depending on the kind of resubmission. Even with the submission of additional information, the FDA ultimately may decide that the
application does not satisfy the regulatory criteria for approval. If and when those conditions

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have been met to the FDA’s satisfaction, the FDA may issue an approval letter. An approval letter authorizes commercial marketing of the drug with specific
prescribing information for specific indications.

The FDA may delay or refuse approval of an NDA if applicable regulatory criteria are not satisfied, require additional testing or information and/or

require post-marketing testing and surveillance to monitor safety or efficacy of a product, or impose other conditions, including distribution restrictions or
other risk management mechanisms. For example, the FDA may require a risk evaluation and mitigation strategy (REMS), as a condition of approval or
following approval to mitigate any identified or suspected serious risks and ensure safe use of the drug. The FDA may prevent or limit further marketing of a
product, or impose additional post-marketing requirements, based on the results of post-marketing studies or surveillance programs. After approval, some
types of changes to the approved product, such as adding new indications, manufacturing changes and additional labeling claims, are subject to further testing
requirements, FDA notification and FDA review and approval. Further, should new safety information arise, additional testing, product labeling or FDA
notification may be required.

If regulatory approval of a product is granted, such approval may entail limitations on the indicated uses for which such product may be marketed or

may include contraindications, warnings or precautions in the product labeling, which has resulted in a boxed warning. The FDA also may not approve the
inclusion of labeling claims necessary for successful marketing. Once approved, the FDA may withdraw the product approval if compliance with pre- and
post-marketing regulatory standards is not maintained or if problems occur after the product reaches the marketplace. In addition, the FDA may require Phase
IV post-marketing studies to monitor the effect of approved products and may limit further marketing of the product based on the results of these post-
marketing studies.

Post-approval Requirements

Any products manufactured or distributed by us pursuant to FDA approvals are subject to continuing regulation by the FDA, including
manufacturing, periodic reporting, product sampling and distribution, advertising, promotion, drug shortage reporting, compliance with any post-approval
requirements imposed as a conditional of approval such as Phase 4 clinical trials, Risk Evaluation and Mitigation Strategy (REMS) and surveillance,
recordkeeping and reporting requirements, including adverse experiences.

After approval, most changes to the approved product, such as adding new indications or other labeling claims are subject to prior FDA review and

approval. There also are continuing, annual program user fee requirements for any approved products, as well as new application fees for supplemental
applications with clinical data.

Drug manufacturers and their subcontractors are required to register their establishments with the FDA and certain state agencies and to list their

drug products and are subject to periodic announced and unannounced inspections by the FDA and these state agencies for compliance with cGMPs and other
requirements, which impose procedural and documentation requirements upon us and our third-party manufacturers. We cannot be certain that we or our
present or future suppliers will be able to comply with the cGMP regulations and other FDA regulatory requirements.

Changes to the manufacturing process are strictly regulated and often require prior FDA approval before being implemented, or FDA notification.

FDA regulations also require investigation and correction of any deviations from cGMPs and specifications and impose reporting and documentation
requirements upon the sponsor and any third-party manufacturers that the sponsor may decide to use. Accordingly, manufacturers must continue to expend
time, money and effort in the area of production and quality control to maintain cGMP compliance.

Later discovery of previously unknown problems with a product, including adverse events (AEs) of unanticipated severity or frequency, or with
manufacturing processes, or failure to comply with regulatory requirements, may result in withdrawal of marketing approval, mandatory revisions to the
approved labeling to add new safety information or other limitations, imposition of post-market studies or clinical trials to assess new safety risks, or
imposition of distribution or other restrictions under a REMS program, among other consequences.

The FDA closely regulates the marketing and promotion of drugs. A company can make only those claims relating to safety and efficacy, purity and

potency that are approved by the FDA. Physicians, in their independent professional medical judgement, may prescribe legally available products for uses
that are not described in the product’s labeling and that differ from those tested by us and approved by the FDA. We, however, are prohibited from marketing
or promoting drugs for uses outside of the approved labeling but may share truthful and not misleading information that is otherwise consistent with the
product’s approved labeling.

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In addition, the distribution of prescription pharmaceutical products, including samples, is subject to the Prescription Drug Marketing Act (PDMA),

which regulates the distribution of drugs and drug samples at the federal level, and sets minimum standards for the registration and regulation of drug
distributors by the states. Both the PDMA and state laws limit the distribution of prescription pharmaceutical product samples and impose requirements to
ensure accountability in distribution. The Drug Supply Chain Security Act also imposes obligations on manufacturers of pharmaceutical products related to
product and tracking and tracing.

Failure to comply with any of the FDA’s requirements could result in significant adverse enforcement actions. These include a variety of
administrative or judicial sanctions, such as refusal to approve pending applications, license suspension or revocation, withdrawal of an approval, imposition
of a clinical hold or termination of clinical trials, warning letters, untitled letters, cyber letters, modification of promotional materials or labeling, product
recalls, product seizures or detentions, refusal to allow imports or exports, total or partial suspension of production or distribution, debarment, injunctions,
fines, consent decrees, corporate integrity agreements, refusals of government contracts and new orders under existing contracts, exclusion from participation
in federal and state healthcare programs, restitution, disgorgement or civil or criminal penalties, including fines and imprisonment. Any of these sanctions
could result in adverse publicity, among other adverse consequences.

The Hatch-Waxman Act

In seeking approval for a drug through an NDA, applicants are required to list with the FDA each patent with claims that cover the applicant’s drug.

Upon approval of a drug, each of the patents listed in the application for the drug is then published in the FDA’s Orange Book. Drugs listed in the Orange
Book can, in turn be cited by potential competitors in support of approval of an ANDA. An ANDA provides for marketing of a drug that has the same active
ingredients in the same strengths and dosage form as the listed drug and has been shown through bioequivalence testing to be therapeutically equivalent to the
listed drug. ANDA applicants are not required to conduct or submit results of preclinical or clinical tests to prove the safety or effectiveness of their drug,
other than the requirement for bioequivalence testing. Drugs approved in this way are commonly referred to as “generic equivalents” to the listed drug, and
can often be substituted by pharmacists under prescriptions written for the original listed drug.

The ANDA applicant is required to certify to the FDA concerning any patents listed for the approved drug in the Orange Book. Specifically, the

applicant must certify that: (i) the required patent information has not been filed; (ii) the listed patent has expired; (iii) the listed patent has not expired, but
will expire on a particular date and approval is sought after patent expiration; or (iv) the listed patent is invalid or will not be infringed by the new drug. A
certification that the new drug will not infringe the already approved drug’s listed patents or that such patents are invalid is called a Paragraph IV certification.
If the applicant does not challenge the listed patents, the ANDA application will not be approved until all the listed patents claiming the referenced drug have
expired.

If the ANDA applicant has provided a Paragraph IV certification to the FDA, the applicant must also send notice of the Paragraph IV certification to

the NDA and patent holders once the ANDA has been accepted for filing by the FDA. The NDA and patent holders may then initiate a patent infringement
lawsuit in response to the notice of the Paragraph IV certification. The filing of a patent infringement lawsuit within 45 days of the receipt of a Paragraph IV
certification automatically prevents the FDA from approving the ANDA until the earlier of 30 months, expiration of the patent, settlement of the lawsuit or a
decision in the infringement case that is favorable to the ANDA applicant.

The ANDA application also will not be approved until any non-patent exclusivity, such as exclusivity for obtaining approval of a NCE, listed in the
Orange Book for the referenced drug has expired. The U.S. Drug Price Competition and Patent Term Restoration Act of 1984, more commonly known as the
“Hatch-Waxman Act,” provides a period of five years following approval of a drug containing no previously approved active ingredients, during which
ANDAs for generic versions of those drugs cannot be submitted unless the submission contains a Paragraph IV challenge to a listed patent, in which case the
submission may be made four years following the original drug approval. Federal law provides for a period of three years of exclusivity following approval of
a listed drug that contains previously approved active ingredients but is approved in a new dosage form, route of administration or combination, or for a new
use, the approval of which was required to be supported by new clinical trials conducted by or for the sponsor, during which FDA cannot grant effective
approval of an ANDA based on that listed drug.

Foreign regulation

Regardless of whether we obtain FDA approval for a product, we must obtain approval by the comparable regulatory authorities of foreign countries
before we can commence clinical trials or marketing of the product in those countries. The approval process varies from country to country, and the time may
be longer or shorter than that required for FDA approval.

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The requirements governing the conduct of clinical trials, product licensing, pricing and reimbursement also vary greatly from country to country. Although
governed by the applicable country, clinical trials conducted outside of the U.S. typically are administered with the three-Phase sequential process that is
discussed above under “United States government regulation.” However, the foreign equivalent of an IND is not a prerequisite to performing pilot studies or
Phase I clinical trials.

Under E.U. regulatory systems, we may submit Marketing Authorization Applications (MAAs) either under a centralized or decentralized procedure.

The centralized procedure, which is available for drugs produced by biotechnology or which are highly innovative, provides for the grant of a single
marketing authorization that is valid for all E.U. member states. This authorization is a marketing authorization approval. The decentralized procedure
provides for mutual recognition of national approval decisions. Under this procedure, the holder of a national marketing authorization may submit an
application to the remaining member states. Within 90 days of receiving the applications and assessment report, each member state must decide whether to
recognize approval. This procedure is referred to as the mutual recognition procedure. In addition, regulatory approval of prices is required in most countries
other than the U.S. We face the risk that the resulting prices would be insufficient to generate an acceptable return to us.

Pharmaceutical Coverage, Pricing and Reimbursement

Significant uncertainty exists as to the coverage and reimbursement status of products approved by the FDA and other government authorities. Sales
of products will depend, in part, on the extent to which the costs of the products will be covered by third-party payors, including government health programs
in the United States such as Medicare and Medicaid, commercial health insurers and managed care organizations. The process for determining whether a
payor will provide coverage for a product may be separate from the process for setting the price or reimbursement rate that the payor will pay for the product
once coverage is approved. Third-party payors are increasingly challenging the prices charged, examining the medical necessity, and reviewing the cost-
effectiveness of medical products and services and imposing controls to manage costs. Third-party payors may also limit coverage to specific products on an
approved list, or formulary, which might not include all of the approved products for a particular indication.

In order to secure coverage and reimbursement for any product that might be approved for sale, a company may need to conduct expensive
pharmacoeconomic studies in order to demonstrate the medical necessity and cost-effectiveness of the product, in addition to the costs required to obtain FDA
or other comparable regulatory approvals. A payor’s decision to provide coverage for a drug product does not imply that an adequate reimbursement rate will
be approved. Third-party reimbursement may not be sufficient to maintain price levels high enough to realize an appropriate return on investment in product
development.

The containment of healthcare costs has become a priority of federal, state and foreign governments and the prices of drugs have been a focus in this
effort. Governments have shown significant interest in implementing cost-containment programs, including price controls, restrictions on reimbursement and
requirements for substitution of generic products. Adoption of price controls and cost-containment measures, and adoption of more restrictive policies in
jurisdictions with existing controls and measures, could further limit a company’s revenue generated from the sale of any approved products. Coverage
policies and third-party reimbursement rates may change at any time. Even if favorable coverage and reimbursement status is attained for one or more
products for which a company or its collaborators receive marketing approval, less favorable coverage policies and reimbursement rates may be implemented
in the future. In the E.U., pricing and reimbursement schemes vary widely from country to country. Some countries provide that drug products may be
marketed only after a reimbursement price has been agreed. Some countries may require the completion of additional studies that compare the cost-
effectiveness of a particular drug candidate to currently available therapies, or so called health technology assessments, in order to obtain reimbursement or
pricing approval. For example, the E.U. provides options for its member states to restrict the range of drug products for which their national health insurance
systems provide reimbursement and to control the prices of medicinal products for human use. E.U. member states may approve a specific price for a drug
product or may instead adopt a system of direct or indirect controls on the profitability of the company placing the drug product on the market. Other member
states allow companies to fix their own prices for drug products, but monitor and control company profits. The downward pressure on health care costs in
general, particularly prescription drugs, has become intense. As a result, increasingly high barriers are being erected to the entry of new products. In addition,
in some countries, cross-border imports from low-priced markets exert competitive pressure that may reduce pricing within a country. Any country that has
price controls or reimbursement limitations for drug products may not provide favorable reimbursement and pricing arrangements.

A primary trend in the U.S. healthcare industry and elsewhere is cost containment. There have been a number of federal and state proposals during

the last several years regarding the pricing of pharmaceutical and biopharmaceutical products, limiting coverage and reimbursement for drugs and other
medical products, government control and other changes to the healthcare system in the U.S.

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The U.S. and state governments continue to propose and pass legislation designed to reduce the cost of healthcare. By way of example, the 2010

Affordable Care Act (ACA), among other things, includes changes to the coverage and payment for products under government health care programs. Among
the provisions of the ACA of importance to potential drug candidates are:

•

an annual, nondeductible fee on any entity that manufactures or imports specified branded prescription drugs and biologic agents, apportioned
among these entities according to their market share in certain government healthcare programs, although this fee does not apply to sales of
certain products approved exclusively for orphan indications;

expansion of eligibility criteria for Medicaid programs by, among other things, allowing states to offer Medicaid coverage to certain individuals
with income at or below 133% of the federal poverty level, thereby potentially increasing a manufacturer’s Medicaid rebate liability;

expanded manufacturers’ rebate liability under the Medicaid Drug Rebate Program by increasing the minimum rebate for both branded and
generic drugs and revising the definition of “average manufacturer price,” or AMP, for calculating and reporting Medicaid drug rebates on
outpatient prescription drug prices and extending rebate liability to prescriptions for individuals enrolled in Medicaid managed care plans;

addressed a new methodology by which rebates owed by manufacturers under the Medicaid Drug Rebate Program are calculated for drugs that
are inhaled, infused, instilled, implanted or injected;

expanded the types of entities eligible for the 340B drug discount program;

established the Medicare Part D coverage gap discount program by requiring manufacturers to provide a 50% point‑of‑sale‑discount off the
negotiated price of applicable brand drugs to eligible beneficiaries during their coverage gap period as a condition for the manufacturers’
outpatient drugs to be covered under Medicare Part D. The Bipartisan Budget Act of 2018 increased the manufacturer discount from 50% to
70% effective in 2019;

established a new Patient‑Centered Outcomes Research Institute to oversee, identify priorities in, and conduct comparative clinical effectiveness
research, along with funding for such research;

established the Independent Payment Advisory Board (IPAB), which has authority to recommend certain changes to the Medicare program to
reduce expenditures by the program that could result in reduced payments for prescription drugs. However, the IPAB implementation has been
not been clearly defined. The ACA provided that under certain circumstances, IPAB recommendations will become law unless Congress enacts
legislation that will achieve the same or greater Medicare cost savings; and

established the Center for Medicare and Medicaid Innovation within CMS to test innovative payment and service delivery models to lower
Medicare and Medicaid spending, potentially including prescription drug spending. Funding has been allocated to support the mission of the
Center for Medicare and Medicaid Innovation from 2011 to 2019.

Other legislative changes have been proposed and adopted since the ACA was enacted. These changes include the Budget Control Act of 2011,
which, among other things, led to aggregate reductions to Medicare payments to providers of up to 2% per fiscal year that started in 2013 and will stay in
effect through 2024 unless additional congressional action is taken, and the American Taxpayer Relief Act of 2012, which, among other things, reduced
Medicare payments to several types of providers and increased the statute of limitations period for the government to recover overpayments to providers
from three to five years. These new laws may result in additional reductions in Medicare and other healthcare funding and otherwise affect the prices we may
obtain for any of our product candidates for which we may obtain regulatory approval or the frequency with which any such product candidate is prescribed
or used. Further, there have been several recent U.S. congressional inquiries and proposed state and federal legislation designed to, among other things, bring
more transparency to drug pricing, review the relationship between pricing and manufacturer patient programs, reduce the costs of drugs under Medicare and
reform government program reimbursement methodologies for drug products.

These healthcare reforms, as well as other healthcare reform measures that may be adopted in the future, may result in additional reductions in

Medicare and other healthcare funding, more rigorous coverage criteria, new payment methodologies and additional downward pressure on the price for any
approved product and/or the level of reimbursement physicians receive for administering any approved product. Reductions in reimbursement levels may
negatively impact the prices we can charge or the frequency with which products are prescribed or administered. Any reduction in reimbursement from
Medicare or other government programs may result in a similar reduction in payments from private payors. Since enactment of the ACA, there have been
numerous legal challenges and congressional actions to repeal and replace provisions of the law. Various pieces of

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legislation have been proposed and/or passed by each of the chambers of Congress to achieve those objectives, but to date, few of these measures have been
implemented.

The current presidential administration has also taken executive actions to undermine or delay implementation of the ACA. In January 2017, the

President signed an Executive Order directing federal agencies with authorities and responsibilities under the ACA to waive, defer, grant exemptions from, or
delay the implementation of any provision of the ACA that would impose a fiscal or regulatory burden on states, individuals, healthcare providers, health
insurers, or manufacturers of pharmaceuticals or medical devices. In October 2017, the President signed a second Executive Order allowing for the use of
association health plans and short-term health insurance, which may provide fewer health benefits than the plans sold through the ACA exchanges. At the
same time, the Administration announced that it will discontinue the payment of cost-sharing reduction (CSR) payments to insurance companies until
Congress approves the appropriation of funds for such CSR payments. The loss of the CSR payments is expected to increase premiums on certain policies
issued by qualified health plans under the ACA and is currently being challenged in court.

More recently, with enactment of the Tax Cuts and Jobs Act of 2017 (TCJA), Congress repealed the “individual mandate.” The repeal of this
provision, which requires most Americans to carry a minimal level of health insurance, became effective on January 1, 2019. According to the Congressional
Budget Office, the repeal of the individual mandate will cause 13 million fewer Americans to be insured in 2027 and premiums in insurance markets may
rise. Additionally, in January 2018, the President signed a continuing resolution on appropriations for fiscal year 2018 that delayed the implementation of
certain ACA-mandated fees, including the so-called “Cadillac” tax on certain high cost employer-sponsored insurance plans, the annual fee imposed on
certain health insurance providers based on market share, and the medical device excise tax on non-exempt medical devices. In December 2018, a federal
district court judge in Texas found the ACA to be unconstitutional, although the ruling was stayed while the case is appealed.

Further, there have been several recent U.S. congressional inquiries and both federal and state legislation, proposed or enacted, designed to, among
other things, bring more transparency to drug pricing, review the relationship between pricing and manufacturer patient programs, reduce the costs of drugs
under Medicare and reform government program reimbursement methodologies for drug products. At the federal level, Congress and the current presidential
administration have each indicated that they will continue to seek new legislative and/or administrative measures to control drug costs. In May 2018, the
Administration issued "American Patients First," a multi-faceted blueprint to lower drug prices. The Administration has taken administrative steps to
implement the blueprint, including through proposing sweeping demonstration projects aimed at putting downward pressure on drug prices. At the state level,
individual states are increasingly aggressive in passing legislation and implementing regulations designed to control pharmaceutical and biological product
pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access and marketing cost disclosure and transparency
measures, and, in some cases, designed to encourage importation from other countries and bulk purchasing. In addition, regional health care authorities and
individual hospitals are increasingly using bidding procedures to determine what pharmaceutical products and which suppliers will be included in their
prescription drug and other health care programs. These measures could reduce the ultimate demand for our products, once approved, or put pressure on our
product pricing.

Employees

We had 284 full-time employees as of December 31, 2019, compared with 270 employees as of December 31, 2018. None of our employees are

represented by a labor union. We have not experienced any work stoppages and consider our employee relations to be good.

Corporate Information

We were incorporated in Delaware in 2002. Our principal executive offices are located at 2200 Pennsylvania Avenue NW, Suite 300E, Washington

D.C. 20037, and our telephone number is (202) 734-3400. Our website address is www.vandapharma.com and the information contained in, or that can be
accessed through, our website is not part of this Annual Report and should not be considered part of this Annual Report.

Available Information

We file annual, quarterly, and current reports, proxy statements, and other documents with the Securities and Exchange Commission (SEC) under the
Securities Exchange Act of 1934 (Exchange Act). The SEC maintains a website at www.sec.gov that contains reports, proxy and information statements, and
other information regarding issuers, including us, that file electronically with the SEC.

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We also make available free of charge on our Internet website at www.vandapharma.com our annual reports on Form 10-K, quarterly reports on

Form 10-Q, current reports on Form 8-K, and, if applicable, amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the
Exchange Act as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC.

Our code of ethics, other corporate policies and procedures, and the charters of our Audit Committee, Compensation Committee and

Nominating/Corporate Governance Committee are available through our Internet website at www.vandapharma.com.

ITEM 1A.

RISK FACTORS

Our business, financial condition and operating results can be affected by a number of factors, whether currently known or unknown, including but
not limited to those described below, any one or more of which could, directly or indirectly, cause our actual operating results and financial condition to vary
materially from past, or anticipated future, operating results and financial condition. Any of these factors, in whole or in part, could materially and adversely
affect our business, financial condition, operating results and the price of our common stock.

The following discussion of risk factors contains forward-looking statements. These risk factors may be important to understanding any statement in
this Annual Report or elsewhere. The following information should be read in conjunction with the consolidated financial statements and related notes in Part
II, Item 8, Financial Statements and Supplementary Data and Part II, Item 7, Management’s Discussion and Analysis of Financial Condition and Results of
Operations.

Because of the following factors, as well as other factors affecting our financial condition and operating results, past financial performance should

not be considered to be a reliable indicator of future performance, and investors should not use historical trends to anticipate results or trends in future
periods.

Risks related to our business and industry

We are dependent on the commercial success of HETLIOZ® and Fanapt®.

Our future success is currently substantially dependent upon the commercial success of HETLIOZ® for the treatment of Non-24-Hour Sleep-Wake

Disorder (Non-24) and Fanapt® for the treatment of schizophrenia.

In January 2014, the U.S. Food and Drug Administration (FDA) approved our New Drug Application (NDA) for HETLIOZ® for the treatment of
Non-24 and in April 2014, we commenced the U.S. commercial launch of HETLIOZ®. In July 2015, the European Commission (EC) granted centralized
marketing authorization with unified labeling for HETLIOZ® for the treatment of Non-24 in totally blind adults, and in August 2016 we commenced the
commercial launch of HETLIOZ® in Germany. This authorization is valid in the 27 countries that are members of the European Union (E.U.), as well as
European Economic Area members Iceland, Liechtenstein and Norway. We have applied for renewal of this marketing authorization which expires in the
ordinary course in July 2020.

In the fourth quarter of 2014, we acquired the U.S. commercial rights to Fanapt®, and began selling, marketing and distributing Fanapt® in the U.S.

Our ability to generate significant product revenue from sales of HETLIOZ® and Fanapt®, both in the U.S. and abroad, in the near term will depend

on, among other things, our ability to:

•

defend our patents and intellectual property from generic competition;

• maintain commercial manufacturing arrangements with third-party manufacturers;

•

produce, through a validated process, sufficiently large quantities of inventory of our products to meet demand;

continue to maintain and grow a wide variety of internal sales, distribution and marketing capabilities sufficient to sustain growth in sales of our
products;

gain broad acceptance of our products from physicians, health care payors, patients, pharmacists and the medical community;

properly price and obtain adequate coverage and reimbursement of these products by governmental authorities, private health insurers, managed
care organizations and other third-party payors;

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• maintain compliance with ongoing labeling, packaging, storage, advertising, promotion, recordkeeping, safety and other post-market

requirements;

•

obtain regulatory approval to expand the labeling of our approved products for additional indications;

obtain regulatory approval for HETLIOZ® or Fanapt® in additional countries;

renew and maintain our existing regulatory approval for HETLIOZ® in Europe;

adequately protect against and effectively respond to any claims by holders of patents and other intellectual property rights that our products
infringe their rights; and

adequately protect against and effectively respond to any unanticipated adverse effects or unfavorable publicity that develops in respect to our
products, as well as the emergence of new or existing competitive products, which may be proven to be more clinically effective and cost-
effective.

We expect to continue to incur significant expenses and to utilize a substantial portion of our cash resources as we continue the commercialization of

HETLIOZ® and Fanapt®, evaluate foreign market opportunities for HETLIOZ® and Fanapt® and continue to grow our operational capabilities, both
domestically and abroad. This activity represents a significant investment in the commercial success of HETLIOZ® and Fanapt®, which is uncertain.

If our continued commercial efforts are not successful with respect to HETLIOZ® and Fanapt® in the U.S., Europe or other jurisdictions in which

these products may be approved for sale, our ability to generate increased product sales revenue may be jeopardized.

The cost of growing and maintaining a sales, marketing and distribution organization may exceed its cost effectiveness. If we fail to continue to

develop sales, marketing and distribution capabilities, if sales efforts are not effective or if costs of developing sales, marketing and distribution capabilities
exceed their cost effectiveness, our business, results of operations and financial condition could be materially adversely affected.

Growth of HETLIOZ® and Fanapt® may be slow or limited for a variety of reasons including competing products or unanticipated safety issues. If

either HETLIOZ® or Fanapt® is not successful in gaining broad commercial acceptance, our business would be harmed.

Any increase in sales of HETLIOZ® and Fanapt® will be dependent on several factors, including our ability to educate physicians and to increase

physician awareness of the benefits of our products relative to competing products. The degree of further market acceptance of any of our products or market
acceptance of approved product candidates among physicians, patients, health care payors and the medical community will depend on a number of factors,
including but not limited to:

•

acceptable evidence of safety and efficacy;

relative convenience and ease of administration;

the prevalence and severity of any adverse side effects;

availability of alternative treatments; and

pricing and cost effectiveness.

In addition, HETLIOZ® and Fanapt® are subject to continual review by the FDA, and we cannot assure that newly discovered or reported safety

issues will not arise. With the use of any newly marketed drug by a wider patient population, serious adverse events may occur from time to time that initially
do not appear to relate to the drug itself. Any safety issues could cause us to suspend or cease marketing of our approved products, cause us to modify how we
market our approved products, subject us to substantial liabilities and adversely affect our revenues and financial condition. In the event of a withdrawal of
either HETLIOZ® or Fanapt® from the market, our revenues would decline significantly and our business would be seriously harmed.

If the FDA does not accept for filing the NDAs that we may submit for tradipitant for the treatment of atopic dermatitis, the treatment of
gastroparesis, and the treatment of motion sickness, or the FDA determines that our clinical trial results for tradipitant for the treatment of atopic
dermatitis, the treatment of gastroparesis or the treatment of motion sickness do not demonstrate adequate safety and efficacy, or the FDA does not
approve an applicable PDUFA-VI date, continued development of tradipitant will be significantly delayed or terminated, our business will be significantly
harmed, and the market price of our stock could decline.

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In October 2019, we completed enrollment in EPIONE, a Phase III clinical study of tradipitant for the treatment of pruritus in atopic dermatitis and

commenced enrollment in EPIONE 2, a second Phase III clinical study of tradipitant for the treatment of atopic dermatitis. Additionally, in the second quarter
of 2019 we initiated a Phase III clinical study of tradipitant for the treatment of gastroparesis. If the results of our ongoing studies of tradipitant for the
treatment of atopic dermatitis, gastroparesis and/or motion sickness are positive, we will likely submit an NDA with the FDA for these indications. Any
adverse developments or results or perceived adverse developments or results with respect to our pre-NDA meeting with the FDA, our regulatory submission
or the tradipitant clinical programs in any or all indications will significantly harm our business and could cause the market price of our stock to decline.
Examples of such adverse developments include, but are not limited to:

•

the FDA determining that additional clinical studies are required with respect to tradipitant for the treatment of atopic dermatitis and/or the
treatment of gastroparesis and/or the treatment of motion sickness;

safety, efficacy or other concerns arising from clinical or non-clinical studies in these programs; or

the FDA determining that the tradipitant clinical trial programs raise safety concerns or do not demonstrate adequate efficacy.

In April 2018, we submitted a protocol amendment to the FDA, proposing a 52-week open-label extension (OLE) period for patients who had
completed the randomized clinical study (2301 study) of tradipitant as a monotherapy in the treatment of gastroparesis. In May 2018, based on feedback from
the FDA, we amended the protocol to limit the duration of treatment in the 2301 study to a total of three months, while continuing to seek further dialogue
with the FDA on extending the study duration to 52-weeks. As a part of this negotiation process, in September 2018, we submitted a new follow-on 52-week
OLE protocol to the FDA (2302 study) for patients who had completed the 2301 study. While waiting for further feedback, we did not enroll any patients in
any study beyond 12 weeks. In December 2018, the FDA imposed a partial clinical hold (PCH) on the two proposed studies, stating that we are required first
to conduct additional chronic toxicity studies in canines, monkeys or minipigs before allowing patients access in any clinical protocol beyond 12 weeks. At
that time, the FDA informed us that the original PCH was not based on any safety or efficacy data related to tradipitant, but rather that these additional
toxicity studies were required by a guidance document. Subsequently, the FDA has taken the position that an additional study was required in order for the
FDA to have adequate toxicology data to undertake a risk analysis of tradipitant.

On February 5, 2019, we filed a lawsuit against the FDA in the United States District Court for the District of Columbia (DC District Court),
challenging the FDA’s legal authority to issue the PCH, and seeking an order to set it aside. In February 2019, the FDA filed a Motion for Voluntary Remand
to the Agency and for a Stay of the Case. In March 2019, the DC District Court granted the FDA’s request for voluntary remand and returned the matter to the
FDA for further consideration. In April 2019, the FDA provided its remand response, in which it indicated that, upon review of scientific literature and
tradipitant data, it believes that a PCH continues to be appropriate until we have safety data from a nine-month non-rodent toxicity study. In May 2019, we
filed an amended complaint, and in July 2019, we filed a Motion for Summary Judgment based on our continuing belief after review of the FDA’s remand
response that additional chronic toxicity studies are unjustified, and that we have provided the FDA with sufficient information regarding the safety of
tradipitant to justify the continued study of tradipitant in patients beyond 12 weeks, in accordance with applicable law and FDA regulations. The FDA filed a
reply and cross-motion for summary judgment in October 2019 and an oral hearing was held on December 13, 2019. On January 31, 2020, the Court granted
the FDA's cross-motion for summary judgment and granted judgment in favor of the FDA on our claims. We are evaluating our options, including a potential
appeal, and we intend to continue vigorously pursuing our interests in the matter. (See Part I, Item 3, Legal Proceedings of this Annual Report for additional
information.)

We do not expect the PCH to have a material impact on our ongoing clinical studies in atopic dermatitis, gastroparesis or motion sickness, each of
which is under 12 weeks in duration and are not subject to the PCH. Nor do we expect the PCH to impact the potential timing of the submission of an NDA
with the FDA. If the matter has not been fully resolved prior to the date on which we are ready to submit the first NDA for tradipitant, then we may choose to
submit with the safety data we have available at that time. We may pursue additional studies of durations in excess of 12 weeks in countries where the
conduct of such studies may be permitted (or we may choose to file for approval of a limited indication). If the FDA continues to recommend that we conduct
a long-term safety study of 12 months duration in humans and determines that our NDA does not contain safety data sufficient for approval, it may not accept
the NDA for filing. We will continue to reassess the situation as events unfold.

Even if we decide to appeal the decision and ultimately prevail, there can be no assurances that the FDA will not attempt to impose a clinical hold or

PCH on other grounds. Any litigation related to this matter is subject to uncertainties and we may not prevail. Because the PCH could, however, impede our
ability to conduct longer term studies of tradipitant, whether the PCH impacts the timing or approvability of NDA filings with the FDA for any indication will
depend on a number of

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factors, including whether the PCH is resolved through the potential appeals of the lawsuit described above, whether we resolve the PCH out of court through
discussions with the FDA, and, in addition to the non-clinical animal studies, whether the FDA considers the clinical trials that we conduct to be sufficient. A
delay in filing, or FDA delay or denial of approval of NDA filings for tradipitant for the treatment of atopic dermatitis, gastroparesis or motion sickness could
materially adversely impact our business.

If the FDA does not approve our supplemental New Drug Application (sNDA) for HETLIOZ® for the treatment jet lag disorder, or does not agree to
an acceptable regulatory path forward for HETLIOZ® for the treatment of Smith-Magenis Syndrome (SMS) or continued development of tasimelteon for
the treatment of either jet lag disorder or SMS is significantly delayed or terminated, our business will be significantly harmed, and the market price of
our stock could decline.

In December 2018, we announced that the FDA had accepted the HETLIOZ® sNDA for the treatment of jet lag disorder. We received a complete
response letter in August 2019 in which the FDA asserted that the measures of the study were of unclear clinical significance and declined to approve our
sNDA. We met with the FDA to discuss the complete response letter in a Post Action meeting and are in ongoing discussions with the FDA on the regulatory
path forward.

For HETLIOZ® for the treatment of SMS, we met with the FDA in the fourth quarter of 2019 to discuss the HETLIOZ® SMS clinical study results.

We submitted an sNDA, including data for a liquid formulation, and expect regulatory action by the FDA in 2020.

Any additional adverse developments or results or perceived adverse developments or results with respect to our regulatory submission for jet lag

disorder or our meeting with the FDA to determine the regulatory path forward for HETLIOZ® for the treatment of SMS will significantly harm our business
and could cause the market price of our stock to decline. Examples of such adverse developments include, but are not limited to:

•

the FDA determining that additional clinical studies are required with respect to either the SMS or jet lag disorder program;

safety, efficacy or other concerns arising from clinical or non-clinical studies in either the SMS or jet lag disorder program, or the manufacturing
processes or facilities used for either the SMS or jet lag disorder programs; or

the FDA determining that either the SMS or jet lag disorder program raises safety concerns or does not demonstrate substantial evidence of
efficacy.

We may enter into third party collaborations from time to time in order to develop and commercialize our products. If we are unable to identify or

enter into an agreement with any material third-party collaborator, if our collaborations with any such third-party are not commercially successful or if
our agreement with any such third-party is terminated or allowed to expire, we could be adversely affected financially or our business reputation could be
harmed.

Our business strategy includes entering into collaborations with corporate collaborators for the commercialization of HETLIOZ®, Fanapt® and our
other products. While we are not currently party to any material commercial collaborative arrangements, areas in which we may potentially enter into third-
party collaboration arrangements include joint sales and marketing arrangements for sales and marketing in certain E.U. countries and elsewhere outside of
the U.S., and future product development arrangements. If we are unable to identify or enter into an agreement with any material third-party collaborator, this
could result in an adverse effect on our business, results of operations or financial condition. Any arrangements we do enter into may not be scientifically or
commercially successful. The termination of any of these arrangements might adversely affect our ability to develop, commercialize and market our products.

The success of our collaboration arrangements will depend heavily on the efforts and activities of our collaborators. Our collaborators will have

significant discretion in determining the efforts and resources that they will apply to these collaborations. We expect that the risks which we face in
connection with these future collaborations will include the following:

•

our collaboration agreements are expected to be for fixed terms and subject to termination under various circumstances, including, in many
cases, on short notice without cause;

our collaborators may develop and commercialize, either alone or with others, products and services that are similar to or competitive with our
products which are the subject of their collaboration with us; and

our collaborators may change the focus of their commercialization efforts.

In recent years there have been a significant number of mergers and consolidations in the pharmaceutical and biotechnology industries, some of

which have resulted in the participant companies reevaluating and shifting the focus of their

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business following the completion of these transactions. The ability of our products to reach their potential could be limited if any of our future collaborators
decreases or fails to increase spending relating to such products.

Collaborations with pharmaceutical companies and other third-parties often are terminated or allowed to expire by the other party. With respect to

our future collaborations, any such termination or expiration could adversely affect us financially as well as harm our business reputation.

Even after we obtain regulatory approvals of a product, acceptance of the product in the marketplace is uncertain and failure to achieve commercial

acceptance will prevent or delay our ability to generate significant revenue from such product.

Even after obtaining regulatory approvals for the sale of our products, the commercial success of these products will depend, among other things, on

their acceptance by physicians, patients, third-party payors and other members of the medical community as therapeutic and cost-effective alternatives to
competing products and treatments. The degree of market acceptance of any product will depend on a number of factors, including the demonstration of its
safety and efficacy, its cost-effectiveness, its potential advantages over other therapies, the reimbursement policies of government and third-party payors with
respect to such product, our ability to attract and maintain corporate partners, including pharmaceutical companies, to assist in commercializing our products,
receipt of regulatory clearance of marketing claims for the uses that we are developing and the effectiveness of our marketing and distribution capabilities. If
our approved products fail to gain market acceptance or do not become widely accepted by physicians, patients, third-party payors and other members of the
medical community, it is unlikely that we will ever become profitable on a sustained basis or achieve significant revenues.

We rely and will continue to rely on outsourcing arrangements for many of our activities, including preclinical and clinical development and supply

of HETLIOZ®, Fanapt® and our other products.

As of December 31, 2019, we had 284 full-time employees. We rely on outsourcing arrangements for a significant portion of our activities, including

distribution, preclinical and clinical research and development, data collection and analysis and manufacturing, as well as for certain functions as a public
company. We have limited control over these third parties and we cannot guarantee that they will perform their obligations in an effective and timely manner.

Disruptions to our HETLIOZ® or Fanapt® supply chains could materially affect our level of success in commercializing HETLIOZ® or Fanapt®,

thereby reducing our future earnings and prospects.

A loss or disruption with any one of our manufacturers or suppliers could disrupt the supply of HETLIOZ® or Fanapt®, possibly for a significant time

period, and we may not have sufficient inventories to maintain supply before the manufacturer or supplier could be replaced or the disruption is resolved. In
addition, marketed drugs and their contract manufacturing organizations are subject to continual review, including review and approval by regulatory
authorities of their manufacturing facilities and the manufacturing processes, which can result in delays in the regulatory approval process and/or
commercialization. Introducing a replacement or backup manufacturer or supplier for HETLIOZ® or Fanapt® requires a lengthy regulatory and commercial
process and there can be no guarantee that we could obtain necessary regulatory approvals in a timely fashion or at all. In addition, it is difficult to identify
and select qualified suppliers and manufacturers with the necessary technical capabilities, and establishing new supply and manufacturing sources involves a
lengthy and technical engineering process.

Failure to comply with government regulations regarding the sale and marketing of our products could harm our business.

Pharmaceutical companies are subject to extensive government regulation and oversight by government authorities in countries in which they do
business. As a result, we may become subject to governmental actions which could materially and adversely affect our business, results of operations and
financial condition, certain of which are described below.

Pharmaceutical Pricing and Reimbursement

In U.S. markets, our ability to commercialize our products successfully, and to attract commercialization partners for our products, should we choose

to do so, depends in significant part on the availability of adequate financial coverage and reimbursement from third-party payors, including, in the U.S.,
governmental payors such as the Medicare and Medicaid programs, managed care organizations, and private health insurers.

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We participate in the Medicaid Drug Rebate Program for both HETLIOZ® and Fanapt®. Under the Medicaid Drug Rebate Program, we are required
to pay a rebate to each state Medicaid program for our covered outpatient drugs that are dispensed to Medicaid beneficiaries and paid for by a state Medicaid
program as a condition of having our drugs eligible for coverage under Medicaid and Medicare Part B. Those rebates are based on pricing data that are
reported by us on a monthly and quarterly basis to the Centers for Medicare & Medicaid Services (CMS). Federal law requires that any company that
participates in the Medicaid Drug Rebate Program also participate in the Public Health Service Act’s 340B drug pricing discount program (340B program), in
order for the manufacturer’s drugs to be eligible for coverage under Medicaid and Medicare Part B. The 340B program requires participating manufacturers
to agree to charge statutorily-defined covered entities no more than the 340B “ceiling price” for the manufacturer’s covered outpatient drugs. The ceiling
price can represent a significant discount and is based on the pricing data reporting to the Medicaid Drug Rebate Program.

The ACA expanded the 340B program to include additional entity types: certain free-standing cancer hospitals, critical access hospitals, rural referral

centers and sole community hospitals, each as defined by ACA. ACA exempts drugs designated under section 526 of the FDC Act as “orphan drugs” from
the ceiling price requirements for these newly-eligible entities.

ACA also obligates the Health Resources and Services Administration to create regulations and processes to improve the integrity of the 340B

program and to update the agreement that manufacturers must sign to participate in the 340B program. A final regulation regarding the calculation of the
340B ceiling price and the imposition of civil monetary penalties on manufacturers that knowingly and intentionally overcharge covered entities became
effective on January 1, 2019. Implementation of this final regulation and the issuance of any other final regulations and guidance could affect our obligations
under the 340B program in ways we cannot anticipate. In addition, legislation may be introduced that, if passed, would further expand the 340B program to
additional covered entities or would require participating manufacturers to agree to provide 340B discounted pricing on drugs used in the inpatient setting.

Federal law also requires that for a drug manufacturer’s products to be eligible for coverage under the Medicaid and Medicare Part B programs and

to be purchased by certain federal agencies and grantees, the manufacturer must participate in the Department of Veterans Affairs Federal Supply Schedule
(FSS), pricing program, established by Section 603 of the Veterans Health Care Act of 1992. Manufacturers that participate in the FSS pricing program must
list their covered (innovator and authorized generic) drugs on an FSS contract and charge no more than Federal Ceiling Price (FCP), to the Department of
Veterans Affairs, Department of Defense, Public Health Service, and Coast Guard when those agencies purchase from the FSS contract or a depot contract.
FCP is calculated based on non-federal average manufacturer price data, which manufacturers must submit quarterly and annually. In addition, because our
products are available in the retail and specialty pharmacy setting, we are required to provide rebates to the Department of Defense for prescriptions
dispensed to Tricare beneficiaries from Tricare retail network pharmacies under the Tricare Retail Refund Program. To the extent we choose to participate in
these government healthcare programs for our current and future products, these and other requirements may affect our ability to profitably sell any product
for which we obtain marketing approval.

Pricing and rebate calculations vary among products and programs. The calculations are complex and will often be subject to interpretation by us,

governmental or regulatory agencies and the courts. If we become aware that our reporting of pricing data for a prior quarter was incorrect, we will be
obligated to resubmit the corrected data. For the Medicaid Drug Rebate Program, corrected data must be submitted for a period not to exceed 12 quarters from
the quarter in which the data originally were due. Such restatements and recalculations increase our costs for complying with the laws and regulations
governing the Medicaid Drug Rebate Program and other governmental pricing programs.

We may be liable for errors associated with our submission of pricing data. If we are found to have knowingly submitted false pricing data to the

Medicaid program or the FSS pricing program, we may be liable for civil monetary penalties in the amount of up to $100,000 per item of false information,
adjusted for inflation as applicable. Our failure to submit pricing data to the Medicaid program or the FSS pricing program on a timely basis could result in a
civil monetary penalty of $10,000 per day for each day the information is late, adjusted for inflation as applicable. Such failure also could be grounds for
CMS to terminate our Medicaid drug rebate agreement, which is the agreement under which we would participate in the Medicaid Drug Rebate Program. In
the event that CMS terminates our rebate agreement, our products may no longer be eligible for coverage under Medicaid or Medicare Part B. There can be
no assurance that our submissions will not be found to be incomplete or incorrect.

Third-party payors decide which drugs they will cover and establish reimbursement and co-pay levels. Third-party payors are increasingly
challenging the prices charged for medical products and services and examining their cost effectiveness, in addition to their safety and efficacy. We may need
to conduct expensive pharmacoeconomic studies in order to demonstrate the cost effectiveness of our products. Even with such studies, any of our products
that are commercialized may be considered

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less cost-effective than other products, and third-party payors may not provide coverage and reimbursement, in whole or in part, for our products.

Political, economic and regulatory influences are subjecting the healthcare industry in the U.S. to fundamental changes. There have been, and we

expect there will continue to be, legislative and regulatory proposals to change the healthcare system pharmaceutical pricing, and reimbursement systems in
ways that could impact our ability to profitably sell commercialized products.

Payors also are increasingly considering new metrics as the basis for reimbursement rates. It is difficult to project the impact of these evolving

reimbursement mechanics on the willingness of payors to cover any of our commercialized products.

In addition, we anticipate that a significant portion of our revenue from sales of commercialized products will be obtained through government
payors, including Medicare and Medicaid. Any failure to obtain eligibility for coverage under those programs for products we are able to commercialize
would have a material adverse effect on revenues and royalties from sales of such products.

Interactions with Healthcare Providers

Physicians and other healthcare providers often play a primary role in the recommendation and prescription of pharmaceutical products.
Manufacturers of branded prescription drugs are subject to broadly applicable fraud and abuse and other healthcare laws and regulations that may constrain
the business or financial arrangements and relationships through which manufacturers market, sell and distribute the products for which they obtain marketing
approval. Some of the laws and regulations that may affect our ability to operate are described below.

Anti-Kickback Laws

The federal Anti-Kickback Statute prohibits, among other things, knowingly and willfully offering, paying, soliciting, or receiving remuneration,

directly or indirectly, in cash or in kind, to induce or reward the purchasing, leasing, ordering or arranging for or recommending the purchase, lease, or order
of any health care item or service reimbursable under federal healthcare programs such as Medicare and Medicaid. The term “remuneration” has been broadly
interpreted to include anything of value, and the government can establish a violation of the Anti-Kickback Statute without proving that a person or entity had
actual knowledge of the law or specific intent to violate it. This statute has been interpreted to apply to arrangements between pharmaceutical manufacturers
on the one hand and prescribers, purchasers, patients, and formulary managers on the other. There are a number of statutory exceptions and regulatory safe
harbors protecting certain common activities from prosecution or other regulatory sanctions, however, the exceptions and safe harbors are drawn narrowly.
Failure to meet all of the requirements of a particular statutory exception or regulatory safe harbor does not make the conduct per se illegal under the Anti-
Kickback Statute, but the legality of the arrangement will be evaluated on a case-by-case basis based on the totality of the facts and circumstances. Violations
of the Anti-Kickback Statute are punishable by imprisonment, criminal fines, civil monetary penalties and exclusion from the participation in federal
healthcare programs, such as Medicare and Medicaid. A number of states also have anti-kickback laws that establish similar prohibitions that may apply to
items or services reimbursed by government programs, as well as any third-party payors, including commercial payors, known as "all-payor" laws.

Federal Food Drug and Cosmetic Act

The Federal Food Drug and Cosmetic Act and its implementing regulations (FDCA) apply to drug product advertising and labeling. The FDCA

provides the FDA with the authority to prohibit drug manufacturers and third parties acting on their behalf from marketing drug products for off-label uses.
Violations of the prohibition can result in warning letters and untitled letters, criminal and civil penalties, including imprisonment and civil monetary
penalties. The U.S. Criminal Code may also apply and permit greater fines than those enumerated in the FDCA.

Prescription Drug Marketing Act

As part of the sales and marketing process, pharmaceutical companies frequently provide healthcare providers with samples of approved drugs. The

Prescription Drug Marketing Act (PDMA) imposes requirements and limitations upon the distribution of drugs and drug samples, and prohibits states from
licensing distributors of prescription drugs unless the state licensing program meets certain federal guidelines that include minimum standards for storage and
handling, as well as record keeping and other requirements. Violations of the PDMA may result in criminal and civil penalties. In addition, ACA imposes
annual reporting requirements related to sample distribution.

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False Claims Act

The federal False Claims Act prohibits, among other things, knowingly presenting, or causing to be presented false or fraudulent claims for payment
of government funds and knowingly making, or causing to be made or used, a false record or statement to get a false claim paid. Certain marketing practices
may implicate the False Claims Act, including promotion of pharmaceutical products for unapproved uses, providing free product to customers with the
expectation that customers would bill federal programs for the product, or inflating prices reported to private price publication services used to set drug
reimbursement rates under federal healthcare programs. In addition, ACA amended the Social Security Act to provide that a claim including items or services
resulting from a violation of the Anti-Kickback Statute constitutes a false claim for purposes of the False Claims Act. Actions under the False Claims Act
may be brought by the government or as a qui tam action by private individuals who may receive financial awards if their claims are successful. False Claims
Act liability is potentially significant in the healthcare industry because the statute provides for treble damages and mandatory penalties of $5,500 to $11,000
per false claim or statement, which increased to a range of $11,181 to $22,363 in January 2018, with respect to violations occurring after November 2, 2015.
Violations of the False Claims Act are also punishable by exclusion from participation in federal healthcare programs, such as Medicare and Medicaid.
Pharmaceutical and other life sciences companies often resolve allegations without admissions of liability for significant and sometimes material amounts to
avoid the uncertainty of treble damages and per claim penalties that may be awarded in litigation. These companies may be required, however, to enter into
corporate integrity agreements with the government, which may impose substantial costs on companies to ensure compliance.

Health Insurance Portability and Accountability Act and Health Information Technology for Economic and Clinical Health Act

The federal Health Insurance Portability and Accountability Act of 1996 (HIPAA), includes federal criminal statutory provisions that prohibit among

other actions, knowingly and willfully executing, or attempting to execute, a scheme to defraud any healthcare benefit program, including private third-party
payors, knowingly and willfully embezzling or stealing from a healthcare benefit program, willfully obstructing a criminal investigation of a healthcare
offense, and knowingly and willfully falsifying, concealing or covering up a material fact or making any materially false, fictitious or fraudulent statement in
connection with the delivery of or payment for healthcare benefits, items or services.

HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act (HITECH) and their implementing regulations,

impose certain requirements and restrictions on certain types of individuals and entities relating to the privacy and security of individually identifiable health
information. Among other things, HITECH makes HIPAA’s privacy and security standards directly applicable not only to covered entities (e.g. health care
providers and health plans), but also to business associates, i.e., independent contractors or agents of covered entities that create, receive, maintain or transmit
protected health information in connection with providing a service for or on behalf of a covered entity. HITECH also created four new tiers of civil monetary
penalties, amended HIPAA to make civil and criminal penalties directly applicable to business associates, and gave state attorneys general new authority to
file civil actions for damages or injunctions in federal courts to enforce the federal HIPAA laws and seek attorneys’ fees and costs associated with pursuing
federal civil actions.

Physician Payment Sunshine Act

The federal Physician Payment Sunshine Act requires manufacturers of drugs, devices, biologics and medical supplies for which payment is

available under Medicare, Medicaid or the Children’s Health Insurance Program to report annually (with certain exceptions) to CMS information related to
payments or other “transfers of value” made to physicians and teaching hospitals, and requires applicable manufacturers and group purchasing organizations
to report annually to CMS ownership and investment interests held by physicians and their immediate family members and payments or other ‘‘transfers of
value’’ to such physician owners. Failure to report relevant data may result in civil fines and/or penalties.

Foreign Corrupt Practices Act

The Foreign Corrupt Practices Act (FCPA), prohibits U.S. corporations and their representatives and intermediaries from offering, promising,
authorizing or making payments to any foreign government official, government staff member, political party or political candidate in an attempt to obtain or
retain business abroad. The scope of the FCPA includes interactions with certain healthcare professionals in many countries. Other countries have enacted
similar anti-corruption laws and/or regulations. Violation of the FCPA could result in substantial civil and criminal penalties and remedies, including fines,
disgorgement, and/or imprisonment.

Analogous State and Foreign Laws

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Analogous state and foreign fraud and abuse laws and regulations, such as state anti-kickback and false claims laws, can apply to our business
practices, including but not limited to research, distribution, sales or marketing arrangements and claims involving healthcare items or services reimbursed by
non-governmental third party payors and are generally broad and are enforced by many different federal and state agencies as well as through private actions.
In addition to requiring reporting transfers of value, some states have imposed price reporting requirements, and an increasing number of countries worldwide
have either adopted or are considering similar laws requiring disclosure of various interactions with healthcare professionals. These state laws apply to items
and services reimbursed under Medicaid and other state programs, or, in several states, apply regardless of the payor. In addition, a number of states require
pharmaceutical companies to report expenses relating to the marketing and promotion of pharmaceutical products and to report gifts and payments to
individual physicians in the states. Other states restrict when pharmaceutical companies may provide meals to prescribers or engage in other marketing related
activities, or require pharmaceutical companies to implement compliance programs or marketing codes of conduct, and file periodic reports or disclosures
with states. Compliance with these laws requires significant resources and companies that do not comply may face civil penalties or other consequences.

Many state laws govern the privacy and security of personal information in specified circumstances. For example, the California Consumer Privacy

Act (CCPA), which became effective on January 1, 2020, established a new legal framework governing covered businesses' collection and use of personal
information of California residents by, among other things, creating an expanded definition of covered personal information, establishing new privacy rights
for California residents, imposing an opt-in standard for certain disclosures of personal information about minors, and creating a new and potentially severe
statutory damages framework for businesses subject to certain data breaches resulting from the failure to implement and maintain reasonable security
procedures and practices. While properly collected clinical trial data and all protected health information governed by HIPAA are exempt from the current
version of the CCPA, other personal information may be applicable and possible changes to the CCPA may broaden its scope.

Outside the U.S., we are subject to similar regulations in those countries where we market and sell products, including with respect to transparency,

bribery and other laws mentioned above. In some foreign countries, including major markets in the E.U. and Japan, the pricing of prescription
pharmaceuticals is subject to governmental control. In these countries, pricing negotiations with governmental authorities can take nine to twelve months or
longer after the receipt of regulatory marketing approval for a product. To obtain reimbursement or pricing approval in some countries, we may be required to
conduct a clinical trial that compares the cost-effectiveness of our product to other available therapies. Our business could be materially harmed if
reimbursement of our products is unavailable or limited in scope or amount or if pricing is set at unsatisfactory levels.

The collection and processing of personal data in the E.U. is governed by the General Data Protection Regulation (GDPR), which became applicable

in May 2018. The GDPR implements stringent operational requirements for processors and controllers of personal data, including, for example, expanded
disclosure requirements about how personal information is to be used, strengthened individual data subject rights, limitations on retention of personal data,
increased requirements pertaining to health data and pseudonymised (i.e., key-coded) data, shortened mandatory data breach notification timelines and higher
standards for controllers to demonstrate they have obtained valid consent for certain data processing activities. The GDPR provides that E.U. member states
may make their own additional laws and regulations in relation to the processing of genetic, biometric or health data, which could result in differences
between member states, limit our ability to use and share personal data or cause our costs to increase, and harm our business and financial condition. Further,
the U.K.’s exit from the E.U. on January 31, 2020, with a transition period through December 31, 2020, often referred to as Brexit, has created uncertainty
with regard to data protection regulation in the U.K. During the transition period, the U.K. will continue to follow E.U. law and will negotiate with the E.U.
on the terms of its relationship post-2020. In particular, it is unclear how data transfers to and from the U.K. will be regulated. We are also subject to evolving
and strict rules on the transfer of personal data out of the E.U. Failure to comply with E.U. data protection laws may result in significant fines, including
GDPR fines of up to the higher of €20,000,000 or 4% of our total worldwide annual turnover of the preceding financial year, and other administrative
penalties, which may be onerous and adversely affect our business, financial condition, results of operations and prospects.

Efforts to ensure that our business arrangements with third parties, and our business generally, will comply with applicable healthcare laws and

regulations may involve substantial costs. It is possible that governmental authorities will conclude that our business practices may not comply with current or
future statutes, regulations, agency guidance or case law involving applicable fraud and abuse or other healthcare laws and regulations. If our operations are
found to be in violation of any of these laws or any other governmental regulations that may apply to us, we may be subject to significant civil, criminal and
administrative penalties, damages, fines, imprisonment, exclusion from government funded healthcare programs, such as Medicare and Medicaid, and the
curtailment or restructuring of our operations.

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Additionally, drug prices are under significant scrutiny, and along with other health care costs, continue to be subject to intense political and societal
pressures, which we anticipate will continue and escalate, including on a global basis. As a result, our business and reputation may be harmed, our stock price
may be adversely impacted and experience periods of volatility, and our results of operations may be adversely impacted.

Other Laws and Regulations

There are evolving legal requirements and other statutory and regulatory regimes that will continue to affect our business.

Efforts to ensure that business activities and business arrangements comply with applicable healthcare laws and regulations can be costly for
manufacturers of branded prescription products. If a manufacturer’s operations, including activities conducted by its sales or marketing teams, are found to be
in violation of any of these laws or any other governmental regulations that apply to the company, the company may be subject to significant civil, criminal
and administrative sanctions, including imprisonment, monetary penalties, damages, fines, exclusion from participation in federal healthcare programs, such
as Medicare and Medicaid, and the curtailment or restructuring of operations.

We intend to seek regulatory approvals for our products in additional foreign jurisdictions, but we may not obtain any such approvals.

We intend to market our products, alone or with others, in foreign jurisdictions. In order to market our products in foreign jurisdictions, we may be
required to obtain separate regulatory approvals and to comply with numerous and varying regulatory requirements. The approval procedure varies among
countries and jurisdictions and can involve additional trials, and the time required to obtain approval may differ from that required to obtain FDA approval.
Additionally, the foreign regulatory approval process may include all of the risks associated with obtaining FDA approval. For all of these reasons, we may
not obtain foreign regulatory approvals on a timely basis, if at all. Approval by the FDA does not ensure approval by regulatory authorities in other countries
or jurisdictions, and approval by one foreign regulatory authority does not ensure approval by regulatory authorities in other foreign countries or jurisdictions
or by the FDA. We may not be able to file for regulatory approvals and may not receive necessary approvals to commercialize our products in any market.
The failure to obtain these approvals could harm our business materially.

We rely on a limited number of specialty pharmacies for distribution of HETLIOZ® in the U.S., and the loss of one or more of these specialty

pharmacies or their failure to distribute HETLIOZ® effectively would materially harm our business.

HETLIOZ® is available for distribution through a limited number of specialty pharmacies in the U.S. A specialty pharmacy is a pharmacy that

specializes in the dispensing of medications for complex or chronic conditions, which often require a high level of patient education and ongoing
management. The use of specialty pharmacies involves certain risks, including, but not limited to, risks that these specialty pharmacies will:

•

not provide us accurate or timely information regarding their inventories, the number of patients who are using HETLIOZ® or complaints about
HETLIOZ®;

reduce their efforts or discontinue to sell or support or otherwise not effectively sell or support HETLIOZ®;

not devote the resources necessary to sell HETLIOZ® in the volumes and within the time frames that we expect;

be unable to satisfy financial obligations to us or others; or

cease operations.

In addition, if one or more of our specialty pharmacies do not fulfill their contractual obligations to us, or refuse or fail to adequately serve patients,
or their agreements are terminated without adequate notice, shipments of HETLIOZ®, and associated revenues, would be adversely affected. We expect that it
would take a significant amount of time if we were required to replace one or more of our specialty pharmacies.

Our revenues from Fanapt® are substantially dependent on sales through a limited number of wholesalers, and such revenues may fluctuate from

quarter to quarter.

We sell Fanapt® primarily through a limited number of pharmaceutical wholesalers in the U.S. The use of pharmaceutical wholesalers involves

certain risks, including, but not limited to, risks that these pharmaceutical wholesalers will:

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•

not provide us accurate or timely information regarding their inventories, demand from wholesaler customers buying Fanapt® or complaints
about Fanapt®;

reduce their efforts or discontinue to sell or support or otherwise not effectively sell or support Fanapt®;

not devote the resources necessary to sell Fanapt® in the volumes and within the time frames that we expect;

be unable to satisfy financial obligations to us or others; or

cease operations.

Additionally, our reliance on a small number of wholesalers could cause revenues to fluctuate from quarter to quarter based on the buying patterns of

these wholesalers. In addition, if any of these wholesalers fails to pay on a timely basis or at all, our business, financial condition and results of operations
could be materially adversely affected.

We face substantial competition, which may result in others developing or commercializing products before or more successfully than we do.

Our future success will depend on our ability to demonstrate and maintain a competitive advantage with respect to our products and our ability to

identify and develop additional products. Large, fully integrated pharmaceutical companies, either alone or together with collaborative partners, have
substantially greater financial resources and have significantly greater experience than we do in:

•

developing products;

undertaking preclinical testing and clinical trials;

obtaining FDA and other regulatory approvals of products; and

• manufacturing, marketing and selling products.

These companies may invest heavily and quickly to discover and develop novel products that could make our products obsolete. Accordingly, our

competitors may succeed in obtaining patent protection, receiving FDA or foreign regulatory approval or commercializing superior products or other
competing products before we do. Technological developments or the FDA or foreign regulatory approval of new therapeutic indications for existing products
may make our products obsolete or may make them more difficult to market successfully, any of which could have a material adverse effect on our business,
results of operations and financial condition.

Our products, if successfully developed and approved for commercial sale, will compete with a number of drugs and therapies currently

manufactured and marketed by major pharmaceutical and other biotechnology companies. Our products may also compete with new products currently under
development by others or with products which may cost less than our products. Physicians, patients, third party payors and the medical community may not
accept or utilize any of our products that may be approved. If HETLIOZ®, Fanapt® and our other products, if and when approved, do not achieve significant
market acceptance, our business, results of operations and financial condition would be materially adversely affected. We believe the primary competitors for
HETLIOZ® and Fanapt® are as follows:

•

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Saphris® (asenapine) by Allergan plc, Latuda® (lurasidone) by Sunovion Pharmaceuticals Inc., Rexulti® (brexpiprazole) by Lundbeck/Otsuka
America Pharmaceutical, Inc., AristadaTM (aripiprazole lauroxil) extended-release injectable suspension by Alkermes, Inc., VraylarTM
(cariprazine) by Teva Pharmaceutical Industries Ltd., CALYPTA® (lumapteperone) by Intra-Cellular Therapies, and generic clozapine, as well as
the typical antipsychotics haloperidol, chlorpromazine, thioridazine, and sulpiride (all of which are generic).

Additionally, we may face competition from newly developed generic products. Under the Hatch-Waxman Act, newly approved drugs and

indications may benefit from a statutory period of non-patent marketing exclusivity. The Hatch-Waxman Act seeks to stimulate competition by providing
incentives to generic pharmaceutical manufacturers to introduce non-infringing forms of patented pharmaceutical products and to challenge patents on
branded pharmaceutical products. If we are unsuccessful at challenging an ANDA, filed pursuant to the Hatch-Waxman Act, cheaper generic versions of our
products, which may be favored by insurers and third-party payors, may be launched commercially, which would significantly harm our business.

To obtain an ANDA approval for a generic drug, the generic company needs to show, among other things, that its version of the product is
bioequivalent to the Reference Listed Drug (RLD). This usually requires the generic company to conduct bioequivalence studies comparing its product to the
RLD, and to retain sufficient samples of the RLD used in testing after a study is complete. In recent years, the U.S. federal lawmakers and the FDA have been
considering proposals to facilitate the generic drug company’s access to samples and foster the generic competition. For example, in February 2019, the U.S.
House and Senate lawmakers reintroduced the Creating and Restoring Equal Access to Equivalent Samples Act (CREATES Act), a bill intended to require
brand drug manufacturers to provide sufficient drug samples to generic and biosimilar drug developers. The proposed legislation, if enacted, would allow a
biosimilar or generic product developer to bring a civil action against a brand drug manufacturer for failing to provide samples of the brand product for
comparative testing “on commercially reasonable, market-based terms.” The developer could receive injunctive relief and a monetary award “sufficient to
deter the license holder from failing to provide other eligible product developers with sufficient quantities of a covered product on commercially reasonable,
market-based terms” in certain cases.

Certain states have also taken similar actions. In 2018, Maine passed a new law that requires brand drug manufacturers to make samples of drugs

distributed in the state available for sale in Maine at a price no greater than wholesale acquisition cost and without any restriction that would block or delay a
biosimilar and generic drug application in a manner inconsistent with federal law. The state may seek injunctive relief and attorney’s fees from a drug
manufacturer who fails to comply with this requirement.

FDA and foreign regulatory approval of our products is uncertain.

The research, testing, manufacturing and marketing of products such as those that we have developed or that we are developing are subject to

extensive regulation by federal, state and local government authorities, including the FDA, as well as foreign regulatory authorities in jurisdictions in which
we seek approval. To obtain regulatory approval of such products, we must demonstrate to the satisfaction of the applicable regulatory agency that, among
other things, the product is safe and effective for its intended use. In addition, we must show that the manufacturing facilities used to produce such products
are in compliance with cGMPs.

The process of obtaining FDA and other required regulatory approvals and clearances can take many years and will require us to expend substantial

time and capital. Despite the time and expense expended, regulatory approval is never guaranteed. The number of preclinical and clinical trials that will be
required for FDA or foreign regulatory approval varies depending on the product, the disease or condition that the product is in development for, and the
requirements applicable to that particular product. The FDA or applicable foreign regulatory agency can delay, limit or deny approval of a product for many
reasons, including that:

•

a product may not be shown to be safe or effective;

the FDA or foreign agency may interpret data from preclinical and clinical trials in different ways than we do;

the FDA or foreign agency may not approve our or our partners’ manufacturing processes or facilities;

a product may not be approved for all the indications we request;

the FDA or foreign agency may change its approval policies or adopt new regulations;

the FDA or foreign agency may not meet, or may extend, the PDUFA-VI date or its foreign equivalent with respect to a particular NDA or
foreign application; and

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•

the FDA or foreign agency may not agree with our regulatory approval strategies or components of the regulatory filings, such as clinical trial
designs.

For example, if certain of our methods for analyzing trial data are not accepted by the FDA or the applicable foreign agency, we may fail to obtain

regulatory approval for our products.

Any delay or failure to obtain regulatory approvals for our products will result in increased costs, could diminish competitive advantages that we

may attain and would adversely affect the marketing and sale of our products. Other than HETLIOZ® in the U.S. and the countries in Europe covered by the
centralized marketing authorization by the EC, and Fanapt® in the U.S., Mexico and Israel, we have not received, and may never receive, regulatory approval
to market any of our products in any jurisdiction.

Even following regulatory approval of our products, the FDA or the applicable foreign agency may impose limitations on the indicated uses for

which such products may be marketed, subsequently withdraw approval or take other actions against us, or such products that are adverse to our business. The
FDA and foreign agencies generally approve drugs for particular indications. An approval for a more limited indication reduces the size of the potential
market for the product. Product approvals, once granted, may be withdrawn or modified if problems occur after initial marketing.

We and our partners also are subject to numerous federal, state, local and foreign laws, regulations and recommendations relating to safe working
conditions, laboratory and manufacturing practices, the environment and the use and disposal of hazardous substances used in connection with discovery,
research and development work. In addition, we cannot predict the extent to which new governmental regulations might significantly impede the discovery,
development, production and marketing of our products. We or our partners may be required to incur significant costs to comply with current or future laws or
regulations, and we may be adversely affected by the cost of such compliance or the inability to comply with such laws or regulations.

If our products are determined to be unsafe or ineffective in humans, whether commercially or in clinical trials, our business will be materially

harmed.

Despite the FDA’s approval of the NDA for HETLIOZ® in January 2014 and the NDA for Fanapt® in May 2009, the EC’s grant of the centralized
marketing authorization for HETLIOZ® in July 2015, and the positive results of our completed trials for HETLIOZ® and Fanapt®, we are uncertain whether
either of these products will ultimately prove to be effective and safe in humans long term and in all uses. Frequently, products that have shown promising
results in clinical trials have suffered significant setbacks in later clinical trials or even after they are approved for commercial sale. Future uses of our
products, whether in clinical trials or commercially, may reveal that the product is ineffective, unacceptably toxic, has other undesirable side effects, is
difficult to manufacture on a large scale, is uneconomical, infringes on proprietary rights of another party or is otherwise not fit for further use. If our products
are determined to be unsafe or ineffective in humans, our business will be materially harmed.

Clinical trials for our products are expensive and their outcomes are uncertain. Any failure or delay in completing clinical trials for our products

could severely harm our business.

Preclinical studies and clinical trials required to demonstrate the safety and efficacy of our products are time-consuming and expensive and together

take several years to complete. Before obtaining regulatory approvals for the commercial sale of any of our products, we must demonstrate through
preclinical testing and clinical trials that such product is safe and effective for use in humans. We have incurred, and we will continue to incur, substantial
expense for, and devote a significant amount of time to, preclinical testing and clinical trials.

Historically, the results from preclinical testing and early clinical trials often have not predicted results of later clinical trials. A number of new drugs
have shown promising results in clinical trials, but subsequently failed to establish sufficient safety and efficacy data to obtain necessary regulatory approvals.
Clinical trials conducted by us or by third parties on our behalf may not demonstrate sufficient safety and efficacy to obtain the requisite regulatory approvals
for our products. Regulatory authorities may not permit us to undertake any additional clinical trials for our products, may force us to stop any ongoing
clinical trials and it may be difficult to design efficacy studies for our products in new indications.

Clinical development efforts performed by us may not be successfully completed, or completed in a timely manner. Completion of clinical trials may

take several years or more. The length of time can vary substantially with the type, complexity, novelty and intended use of the products and the size of the
prospective patient population. Our ability to enroll

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patients in, and the commencement and rate of completion of, clinical trials for our products may be affected by many factors, including:

•

the size and nature of the patient population;

the design of the trial protocol for our clinical trials;

the eligibility and exclusion criteria for the trial in question;

the availability of competing therapies and competing clinical trials, and physician and patient perception of our product candidates and our
other product candidates being studied in relation to these other potential options;

the availability of raw materials and the possibility of raw materials expiring prior to their use;

difficulty in maintaining contact with patients after treatment, resulting in incomplete data;

poor effectiveness of our products during clinical trials;

unforeseen safety issues or side effects;

the number and location of clinical sites in our clinical trials;

the proximity and availability of clinical trial sites for prospective patients;

the availability of time and resources at the institutions where clinical trials are and will be conducted;

the availability of adequate financing to fund ongoing clinical trial expenses;

the study endpoints that rely on subjective patient reported outcomes; and

governmental or regulatory delays and changes in regulatory requirements and guidelines.

If we fail to complete successfully, or have difficulty enrolling a sufficient number of patients for, our clinical trials, we or they may not receive the

regulatory approvals needed to market that product. Any such failure or difficulty could have a material adverse effect on our business.

Our products may cause undesirable side effects or have other properties that could delay, prevent or result in the revocation of their regulatory

approval or limit their marketability.

Undesirable side effects caused by our products could interrupt, delay or halt clinical trials and could result in the denial of regulatory approval by
the FDA or other regulatory authorities for any or all targeted indications, and in turn prevent us from commercializing or continuing the commercialization
of such products and generating revenues from their sale. We will continue to assess the side effect profile of our products in ongoing clinical development
programs. However, we cannot predict whether the commercial use of our approved products (or our products in development, if and when they are approved
for commercial use) will produce undesirable or unintended side effects that have not been evident in the use of, or in clinical trials conducted for, such
products to date. Additionally, incidents of product misuse may occur. These events, among others, could result in product recalls, product liability actions or
withdrawals or additional regulatory controls, all of which could have a material adverse effect on our business, results of operations and financial condition.

In addition, if after receiving marketing approval of a product, we or others identify undesirable side effects caused by such product, we could face

one or more of the following:

•

regulatory authorities may require the addition of labeling statements, such as a “black box” warning or a contraindication;

regulatory authorities may withdraw their approval of the product;

we may be required to change the way the product is administered, conduct additional clinical trials or change the labeling of the product; and

our or the product’s reputation may suffer.

Any of these events could prevent us from achieving or maintaining market acceptance of the affected product or could substantially increase the

costs and expenses of commercializing the product, which in turn could delay or prevent us from generating significant revenues from its sale.

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We have a history of operating losses and may not be able to achieve or sustain profitability in the future.

We have been engaged in identifying and developing drug products since March 2003, which has required, and will continue to require, significant
research and development expenditures. The continued commercialization of HETLIOZ® and Fanapt® will also require substantial additional expenditures.

As of December 31, 2019, we had an accumulated deficit of $220.7 million and we cannot estimate with precision the extent of our future income or

loss. We may not succeed in gaining additional market acceptance of HETLIOZ® and Fanapt® in the U.S. and we may not succeed in commercializing
HETLIOZ® or Fanapt® outside of the U.S. We may not be profitable even if our products are successfully commercialized. We may be unable to fully
develop, obtain regulatory approval for, commercialize, manufacture, market, sell and derive revenue from our products in the timeframes we project, if at all,
and our inability to do so would materially and adversely impact the market price of our common stock and our ability to raise capital and continue
operations.

There can be no assurance that we will achieve sustained profitability, which depends on many factors, including but not limited to, our ability to
obtain regulatory approval for our products and achieve success in commercializing them in the U.S., Europe and our other target jurisdictions, as well as
other factors described in this Annual Report.

In addition, the amount we spend on developing, obtaining and maintaining regulatory approval for and commercializing our products, among other

expenditures described in this Annual Report, will impact our profitability.

Our ability to use net operating loss carryforwards and tax credit carryforwards to offset future taxable income is dependent on generating future

taxable income and may be limited, including as a result of transactions involving our common stock.

We have recorded deferred tax assets based on our assessment that we will be able to realize the benefits of our net operating losses and other
favorable tax attributes. Realization of deferred tax assets involve significant judgments and estimates, which are subject to change and ultimately depends on
generating sufficient taxable income of the appropriate character during the appropriate periods. Changes in circumstances may affect the likelihood of such
realization, which in turn may trigger the need for additional valuation allowance against our deferred tax assets and adversely affect our net income and
financial condition. In addition, we are potentially subject to ongoing and periodic tax examinations and audits in various jurisdictions, including with respect
to the amount of our net operating losses and any limitation thereon. An adjustment to such net operating loss carryforwards, including an adjustment from a
taxing authority, could result in higher tax costs, penalties and interest, thereby adversely impacting our financial condition.

In general, under Section 382 of the Internal Revenue Code of 1986,, as amended (IRC), a corporation that undergoes an “ownership change” is
subject to limitations on its ability to utilize its pre-change net operating losses (NOLs) and certain other tax assets (tax attributes) to offset future taxable
income. In general, an ownership change occurs if the aggregate stock ownership of certain stockholders increases by more than 50 percentage points over
such stockholders’ lowest percentage ownership during the testing period (generally three years). Transactions involving our common stock, even those
outside our control, such as purchases or sales by investors, within the testing period could result in an ownership change. A limitation on our ability to utilize
some or all of our NOLs or credits could have a material adverse effect on our results of operations and cash flows. Ownership changes occurred in the years
ending December 31, 2014 and 2008. We believe that the ownership changes in 2014 and 2008 will not impact our ability to utilize NOL and credit
carryforwards; however, future ownership changes may cause our existing tax attributes to have additional limitations.

If we fail to adequately fund our research and development activities and commercialization efforts, we may be unable to continue operations or we

may be forced to share our rights to commercialize our products with third parties on terms that may not be attractive to us.

Our activities will necessitate significant uses of working capital throughout 2020 and beyond. It is uncertain whether cash provided by our operating

activities, together with our existing funds, will be sufficient to meet our operating needs. As of December 31, 2019, our total cash and cash equivalents and
marketable securities were $312.1 million. Our long term capital requirements are expected to depend on many factors, including, among others:

•

our level of success in commercializing HETLIOZ® and Fanapt® globally;

outcomes of ongoing and potential patent litigation;

costs of developing and maintaining sales, marketing and distribution channels and our ability to sell our products;

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• market acceptance of our products;

•

costs involved in establishing and maintaining manufacturing capabilities for commercial quantities of our products;

the number of potential formulations and products in development;

progress with preclinical studies and clinical trials;

time and costs involved in obtaining regulatory (including FDA) approval;

costs involved in preparing, filing, prosecuting, maintaining and enforcing patent, trademark and other intellectual property claims;

competing technological and market developments;

costs for recruiting and retaining employees and consultants;

costs for training physicians; and

legal, accounting, insurance and other professional and business related costs.

As a result, we may need to raise additional capital to fund our anticipated operating expenses and execute on our business plans. In our capital-

raising efforts, we may seek to sell debt securities or additional equity securities, obtain a bank credit facility, or enter into partnerships or other collaboration
agreements. The sale of additional equity or debt securities, if convertible, could result in dilution to our stockholders and may also result in a lower price for
our common stock. The incurrence of indebtedness would result in increased fixed obligations and could also result in covenants that could restrict our
operations. However, we may not be able to raise additional funds on acceptable terms, or at all. If additional financing is not available when required or is
not available on acceptable terms, we may be unable to fund our operations and planned growth, develop or enhance our technologies or products, take
advantage of business opportunities or respond to competitive market pressures, any of which would materially harm our business, financial condition and
results of operations.

If our contract research organizations (CROs) do not successfully carry out their duties or if we lose our relationships with CROs, our drug

development efforts could be delayed.

Our arrangements with CROs are critical to our success in bringing our products to the market. We are dependent on CROs, third-party vendors and
investigators for preclinical testing and clinical trials related to our drug discovery and development efforts and we will likely continue to depend on them to
assist in our future discovery and development efforts. These parties are not our employees and we cannot control the amount or timing of resources that they
devote to our programs. As such, they may not complete activities on schedule or may not conduct our clinical trials in accordance with regulatory
requirements or our stated protocols. The parties with which we contract for execution of our clinical trials play a significant role in the conduct of the trials
and the subsequent collection and analysis of data. If they fail to devote sufficient time and resources to our drug development programs or if their
performance is substandard, it will delay the development, approval and commercialization of our products. Moreover, these parties may also have
relationships with other commercial entities, some of which may compete with us. If they assist our competitors, it could harm our competitive position.

Our CROs could merge with or be acquired by other companies or experience financial or other setbacks unrelated to our collaboration that could,

nevertheless, materially adversely affect our business, results of operations and financial condition.

If we lose our relationship with any one or more of these parties, we could experience a significant delay in both identifying another comparable

provider and then contracting for its services. We may be unable to retain an alternative provider on reasonable terms, if at all. Even if we locate an alternative
provider, it is likely that this provider may need additional time to respond to our needs and may not provide the same type or level of service as the original
provider. In addition, any provider that we retain will be subject to current Good Laboratory Practices as set forth in 21 Code of Federal Regulations (C.F.R.)
Part 58 and Good Clinical Practices as set forth in 21 C.F.R. Part 50, 54, 58, and 312, and similar international standards and we do not have control over
compliance with these regulations by these providers. Consequently, if these practices and standards are not adhered to by these providers, the development
and commercialization of our products could be delayed.

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We rely on a limited number of third-party manufacturers to formulate and manufacture our products and our business will be seriously harmed if

these manufacturers are not able to satisfy our demand and alternative sources are not available.

We do not have an in-house manufacturing capability and depend completely on a small number of third-party manufacturers and active

pharmaceutical ingredient formulators for the manufacture of our products. Therefore, we are dependent on third parties for our formulation development and
manufacturing of our products. This may expose us to the risk of not being able to directly oversee the production and quality of the manufacturing process
and provide ample commercial supplies to successfully launch and maintain the marketing of our products. Furthermore, these third party contractors,
whether foreign or domestic, may experience regulatory compliance difficulty, mechanical shut downs, employee strikes, or other unforeseeable events that
may delay or limit production. Our inability to adequately establish, supervise and conduct (either ourselves or through third parties) all aspects of the
formulation and manufacturing processes would have a material adverse effect on our ability to develop and commercialize our products.

We have agreements in place with Patheon Pharmaceuticals Inc. and Patheon Inc. (collectively, Patheon), subsidiaries of Thermo Fisher Scientific,

for the manufacture of HETLIOZ® and Fanapt®.

In January 2014, we entered into a manufacturing agreement with Patheon for the manufacture of commercial supplies of HETLIOZ® 20 mg

capsules at Patheon’s Cincinnati, Ohio manufacturing site. In May 2016, we entered into a manufacturing agreement with Patheon for the manufacture of
commercial supplies of Fanapt® tablets at Patheon’s Mississauga, Ontario, Canada manufacturing site. We do not have exclusive long-term agreements with
any other third-party manufacturers of our products. If our current manufacturers, or any other third-party manufacturer, is unable or unwilling to perform its
obligations under our manufacturing agreements for any reason, we may not be able to locate alternative acceptable manufacturers or formulators or enter into
favorable agreements with them. Any inability to acquire sufficient quantities of our products in a timely manner from these third parties could adversely
affect sales of our products, delay clinical trials and prevent us from developing our products in a cost-effective manner or on a timely basis. In addition,
manufacturers of our products are subject to cGMP and similar foreign standards and we do not have control over compliance with these regulations by our
manufacturers. If one of our contract manufacturers fails to maintain compliance, the production of our products could be interrupted, resulting in delays and
additional costs. In addition, if the facilities of such manufacturers do not pass a pre-approval or post-approval plant inspection, the FDA will not grant
approval and may institute restrictions on the marketing or sale of our products.

Our manufacturing strategy presents the following additional risks:

•

because most of our third-party manufacturers and formulators are located outside of the U.S., there may be difficulties in importing our
products or their components into the U.S. as a result of, among other things, FDA import inspections, incomplete or inaccurate import
documentation or defective packaging; and

because of the complex nature of our products, our manufacturers may not be able to successfully manufacture our products in a cost-effective
and/or timely manner.

Materials necessary to manufacture our products may not be available on commercially reasonable terms, or at all, which may delay the

development, regulatory approval and commercialization of our products.

We rely on manufacturers to purchase from third-party suppliers the materials necessary to produce our products for clinical trials and

commercialization. Suppliers may not sell these materials to such manufacturers at the times we need them or on commercially reasonable terms. We do not
have any control over the process or timing of the acquisition of these materials by these manufacturers. Moreover, we currently do not have any agreements
for the commercial production of these materials. If the manufacturers are unable to obtain these materials for our clinical trials, product testing, potential
regulatory approval of our products and commercial scale manufacturing could be delayed, significantly affecting our ability to further develop and
commercialize our products. If we, our manufacturers are unable to purchase these materials for our products, there would be a shortage in supply or the
commercial launch of such products would be delayed, which would materially and adversely affect our ability to generate revenues from the sale of such
products.

If we cannot identify, or enter into licensing arrangements for, new products, our ability to develop a diverse product portfolio will be limited.

A component of our business strategy is acquiring rights to develop and commercialize products discovered or developed by other pharmaceutical
and biotechnology companies for which we may find effective uses and markets through our unique pharmacogenetics and pharmacogenomics expertise for
the treatment of central nervous system disorders. Competition for the acquisition of these products is intense. If we are not able to identify opportunities to
acquire rights to

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commercialize additional products, we may not be able to develop a diverse portfolio of products. Additionally, it may take substantial human and financial
resources to secure commercial rights to promising products. Moreover, if other firms develop pharmacogenetics and pharmacogenomics capabilities, we may
face increased competition in identifying and acquiring additional products.

If we lose key scientists or management personnel, or if we fail to recruit additional highly skilled personnel, it will impair our ability to identify,

develop, and commercialize products.

We are highly dependent on principal members of our management team and scientific staff, including our Chief Executive Officer, Mihael H.

Polymeropoulos, M.D. These executives each have significant pharmaceutical industry experience. The loss of any such executives, including
Dr. Polymeropoulos, or any other principal member of our management team or scientific staff, would impair our ability to identify, develop and market new
products. Our management and other employees may voluntarily terminate their employment with us at any time. The loss of the services of these or other
key personnel, or the inability to attract and retain additional qualified personnel, could result in delays to development or approval, loss of sales and
diversion of management resources. In addition, we depend on our ability to attract and retain other highly skilled personnel, including research scientists.
Competition for qualified personnel is intense, and the process of hiring and integrating such qualified personnel is often lengthy. We may be unable to recruit
such personnel on a timely basis, if at all, which would negatively impact our development and commercialization programs.

Additionally, we do not currently maintain “key person” life insurance on the lives of our executives or any of our employees. This lack of insurance

means that we may not have adequate compensation for the loss of the services of these individuals.

Product liability lawsuits could divert our resources, result in substantial liabilities and reduce the commercial potential of our products.

The risk that we may be sued on product liability claims is inherent in the development and sale of pharmaceutical products. For example, we face a

risk of product liability exposure related to the testing of our products in clinical trials and will face even greater risks upon commercialization of our
products. We believe that we may be at a greater risk of product liability claims relative to other pharmaceutical companies because certain of our products
are intended to treat central nervous system disorders, among others, and it is possible that we may be held liable for the behavior and actions of patients who
use our products. These lawsuits may divert our management from pursuing our business strategy and may be costly to defend. In addition, if we are held
liable in any of these lawsuits, we may incur substantial liabilities and we may be forced to limit or forego further commercialization of one or more of our
products. Although we maintain product liability insurance, our aggregate coverage limit under this insurance is $30.0 million, and while we believe this
amount of insurance is sufficient to cover our product liability exposure, these limits may not be high enough to fully cover potential liabilities. As our
development activities and commercialization efforts progress and we sell our products, this coverage may be inadequate, we may be unable to obtain
adequate coverage at an acceptable cost or we may be unable to get adequate coverage at all or our insurer may disclaim coverage as to a future claim. This
could prevent the commercialization or limit the commercial potential of our products. Even if we are able to maintain insurance that we believe is adequate,
our results of operations and financial condition may be materially adversely affected by a product liability claim. Uncertainties resulting from the initiation
and continuation of products liability litigation or other proceedings could have a material adverse effect on our ability to compete in the marketplace. Product
liability litigation and other related proceedings may also require significant management time.

E.U. Member States tend to impose strict price controls, which may delay or prevent the further commercial launch or impede the commercial

success of HETLIOZ® in Europe and adversely affect our future results of operations.

In the E.U., prescription drug pricing and reimbursement are subject to governmental control and reimbursement mechanisms used by private and

public health insurers in the E.U. vary by Member State. For the public systems, reimbursement is determined by guidelines established by the legislature or
responsible national authority. As elsewhere, inclusion in reimbursement catalogues focuses on the medical usefulness, need, quality and economic benefits to
patients and the health care system. Acceptance for reimbursement comes with cost, use and often volume restrictions, which can vary by Member State.
Although we have received marketing authorization for HETLIOZ® from the EC, pricing negotiations with governmental authorities may take a considerable
amount of time in those Member States that impose price controls. For example, we launched HETLIOZ® commercially in Germany in August 2016, and
concluded our pricing negotiations with German authorities in October 2017. In addition, to obtain reimbursement or pricing approval for HETLIOZ® in
some Member States, we may be required to conduct a clinical trial that compares the cost-effectiveness of HETLIOZ®, to other available therapies.

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Some Member States require approval of the sale price of a drug before it can be marketed. In many countries, the pricing review period begins after
marketing or product licensing approval is granted. In some Member States, prescription pharmaceutical pricing remains subject to continuing governmental
control even after initial approval is granted. As a result, we may be subject to lengthy price regulations that delay or prevent the commercial launch of
HETLIOZ® in a particular Member State and negatively impact the revenues that are generated from the sale of HETLIOZ® in that country. If reimbursement
of HETLIOZ® is unavailable or limited in scope or amount, or if pricing for HETLIOZ® is set at unsatisfactory levels or takes too long to establish, or if there
is competition from lower priced cross-border sales, our results of operations will be negatively affected.

We may not be able to effectively market and sell our future products, if approved, in the U.S.

We plan to continue to build our sales and marketing capabilities in the U.S. to commercialize future products, if approved. Our current sales and

marketing capabilities in the U.S. may not be adequate to support the commercialization of future products and we would expect to build such capabilities by
investing significant amounts of financial and management resources. Furthermore, the cost of establishing and maintaining marketing and sales capabilities
may not be justifiable in light of the revenues generated by any future products.

If we are unable to establish and maintain adequate sales and marketing capabilities for future products or are unable to do so in a timely manner, we

may not be able to generate product revenues from these products which may prevent us from reaching or maintaining profitability.

Healthcare legislative reform measures may have a material adverse effect on our business and results of operations.

In the U.S., there have been and continue to be a number of legislative initiatives to contain healthcare costs. For example, in March 2010, the ACA

was passed, which substantially changes the way healthcare is financed by both governmental and private insurers, and significantly impacts the U.S.
pharmaceutical industry. The ACA, among other things, increases the minimum Medicaid rebates owed by manufacturers under the Medicaid Drug Rebate
Program and extends the rebate program to individuals enrolled in Medicaid managed care organizations, establishes annual fees and taxes on manufacturers
of certain branded prescription drugs, and creates a new Medicare Part D coverage gap discount program, in which manufacturers must agree to offer 70%
point-of-sale discounts off negotiated prices of applicable brand drugs to eligible beneficiaries during their coverage gap period, as a condition for the
manufacturer’s outpatient drugs to be covered under Medicare Part D.

Some of the provisions of the ACA have yet to be fully implemented, while certain provisions have been subject to judicial and Congressional

challenges, as well as efforts by the Trump administration to repeal or replace certain aspects of the ACA. Since January 2017, President Trump has signed
two Executive Orders designed to delay the implementation of certain provisions of the ACA or otherwise circumvent some of the requirements for health
insurance mandated by the ACA. Concurrently, Congress has considered legislation that would repeal or repeal and replace all or part of the ACA. While
Congress has not passed comprehensive repeal legislation, two bills affecting the implementation of certain taxes under the ACA have been signed into law.
The TCJA, includes a provision that repealed, effective January 1, 2019, the tax-based shared responsibility payment by imposed by the ACA on certain
individuals who failed to maintain qualifying health coverage for all or part of a year that is commonly referred to as the “individual mandate.” Additionally,
on January 22, 2018, President Trump signed a continuing resolution on appropriations for fiscal year 2018 that delayed the implementation of certain ACA-
mandated fees, including the so-called “Cadillac” tax on certain high cost employer-sponsored insurance plans, the annual fee imposed on certain high cost
employer-sponsored insurance plans, the annual fee imposed on certain health insurance providers based on market share, and the medical device excise tax
on non-exempt medical devices. Further, the Bipartisan Budget Act of 2018 (BBA), among other things, amended the ACA, effective January 1, 2019, to
reduce the coverage gap in most Medicare drug plans, commonly referred to as the “donut hole.” On December 14, 2018, a U.S. District Court ruled that the
ACA is unconstitutional in its entirety because the “individual mandate” was repealed by Congress as part of the TCJA. Subsequently, the U.S. Fifth Circuit
Court of Appeals upheld the U.S. District Court ruling as to the unconstitutionality of the individual mandate, but remanded the decision for further analysis
of whether the unconstitutionality of one provision would render the entirety of the ACA unconstitutional. While the ruling has no immediate effect pending
review by the lower court and potential appeal of the decision to the U.S. Supreme Court, it is unclear how this decision, subsequent appeals, and other efforts
to repeal and replace the ACA will impact the ACA and our business. The effect that the ACA and its possible repeal and replacement may have on our
business remains unclear.

Other legislative changes have been proposed and adopted in the U.S. since the ACA was enacted. On August 2, 2011, the Budget Control Act of

2011, among other things, included aggregate reductions of Medicare payments to providers of 2% per fiscal year. These reductions went into effect on April
1, 2013 and, due to subsequent legislative amendments to the

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statute, will remain in effect through 2027 unless additional congressional action is taken. On January 2, 2013, the American Taxpayer Relief Act of 2012 was
signed into law, which, among other things, further reduced Medicare payments to several types of providers.

Moreover, payment methodologies may be subject to changes in healthcare legislation and regulatory initiatives. We expect that additional state and

federal healthcare reform measures will be adopted in the future, any of which could limit the amounts that federal and state governments will pay for
healthcare products and services, which could result in reduced demand for any product candidate we develop or complementary diagnostics or companion
diagnostics or additional pricing pressures.

Additionally, there has been increasing legislative and enforcement interest in the U.S. with respect to specialty drug pricing practices. Specifically,

there have been several recent U.S. Congressional inquiries and proposed and enacted federal and state legislation designed to, among other things, bring
more transparency to drug pricing, reduce the cost of prescription drugs under Medicare, review the relationship between pricing and manufacturer patient
programs, and reform government program reimbursement methodologies for drugs. We expect that the healthcare reform measures that have been adopted
and may be adopted in the future, may result in more rigorous coverage criteria and in additional downward pressure on the price that we receive for any
approved product and could seriously harm our future revenues. Any reduction in reimbursement from Medicare or other government programs may result in
a similar reduction in payments from private third-party payors.

Significant developments arising from changes in the political climate could have a material adverse effect on us.

Changes in U.S. social, political, regulatory and economic conditions or in laws and policies governing foreign trade, manufacturing, development

and investment, and any negative sentiments towards the U.S. as a result of such changes, could adversely affect our business.

In addition, the U.K. formally withdrew from the E.U. on January 31, 2020 with a transition period through December 31, 2020. During the

transition period, the U.K. will continue to follow E.U. law and will negotiate with the E.U. on the terms of its relationship post-2020. Since the regulatory
framework for pharmaceutical products in the U.K. covering quality, safety and efficacy of pharmaceutical products, clinical trials, marketing authorization,
commercial sales and distribution of pharmaceutical products is derived from E.U. directives and regulations, Brexit could materially impact the future
regulatory regime which applies to products and the approval of product candidates in the U.K. It remains to be seen how, if at all, Brexit will impact
regulatory requirements for product candidates and products in the U.K. These possible negative impacts, and others resulting from the U.K.’s withdrawal
from the E.U., may adversely affect our operating results and growth prospects as well as the manner in which we conduct our business operations in Europe.

Changes to tax regulations to which we are subject could adversely affect us.

We are subject to tax laws, treaties and regulations in the countries in which we operate, and these laws and treaties are subject to interpretation. New

legislation or regulation which could affect our tax burden could be enacted by any governmental authority. We cannot predict the timing or extent of such
tax-related developments which could have a negative impact on our financial results. We have taken, and will continue to take, tax positions based on our
interpretation of such tax laws. However, a challenge by a taxing authority, our ability to utilize tax benefits such as carryforwards or tax credits, or a
deviation from other tax-related assumptions may cause actual financial results to deviate from previous estimates.

Future transactions may harm our business or the market price of our stock.

We regularly review potential transactions related to technologies, products or product rights and businesses complementary to our business. These

transactions could include:

• mergers;

•

acquisitions;

strategic alliances;

licensing agreements; and

co-promotion and similar agreements.

We may choose to enter into one or more of these transactions at any time, which may cause substantial fluctuations in the market price of our stock.
Moreover, depending upon the nature of any transaction, we may experience a charge to earnings, which could also materially adversely affect our results of
operations and could harm the market price of our stock.

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We may undertake strategic acquisitions in the future, and difficulties integrating such acquisitions could damage our ability to achieve or sustain

profitability.

Although we have no experience in acquiring businesses, we may acquire businesses or assets that complement or augment our existing business. If

we acquire businesses with promising products or technologies, we may not be able to realize the benefit of acquiring such businesses if we are unable to
move one or more products through preclinical and/or clinical development to regulatory approval and commercialization. Integrating any newly acquired
businesses or technologies could be expensive and time-consuming, resulting in the diversion of resources from our current business. We may not be able to
integrate any acquired business successfully. We cannot assure you that, following an acquisition, we will achieve revenues, specific net income or loss levels
that justify the acquisition or that the acquisition will result in increased earnings, or reduced losses, for the combined company in any future period.
Moreover, we may need to raise additional funds through public or private debt or equity financing to acquire any businesses, which would result in dilution
for stockholders or the incurrence of indebtedness and may not be available on terms which would otherwise be acceptable to us. We may not be able to
operate acquired businesses profitably or otherwise implement our growth strategy successfully.

Our operating results may fluctuate significantly due to a number of factors which make our future results difficult to predict and could cause our

operating results to fall below expectations or our guidance.

Our operating results will continue to be subject to fluctuations. The revenues we generate and our operating results will be affected by numerous

factors, including:

•

product sales;

cost of product sales;

• marketing and other expenses;

• manufacturing or supply issues;

•

the timing and amount of royalties or milestone payments;

our addition or termination of development programs;

variations in the level of expenses related to our products or future development programs;

regulatory developments affecting our products or those of our competitors;

our execution of collaborative, licensing or other arrangements, and the timing of payments we may make or receive under these arrangements;

any intellectual property infringement or other lawsuit in which we may become involved; and

the timing and recognition of stock-based compensation expense.

If our operating results fall below the expectations of investors or securities analysts or below any guidance we may provide, the price of our
common stock could decline substantially. Furthermore, any fluctuations in our operating results may, in turn, cause the price of our stock to fluctuate
substantially. We believe that comparisons of our financial results are not necessarily meaningful and should not be relied upon as an indication of our future
performance.

We are increasingly dependent on information technology systems, infrastructure and data. Cybersecurity breaches could expose us to liability,

damage our reputation, compromise our confidential information or otherwise adversely affect our business.

We are increasingly dependent upon information technology systems, infrastructure and data. Our computer systems may be vulnerable to service

interruption or destruction, malicious intrusion and random attack. Security breaches pose a risk that sensitive data, including intellectual property, trade
secrets or personal information may be exposed to unauthorized persons or to the public. Cyber-attacks are increasing in their frequency, sophistication and
intensity, and have become increasingly difficult to detect. Cyber-attacks could include the deployment of harmful malware, denial-of service, social
engineering and other means to affect service reliability and threaten data confidentiality, integrity and availability. Our key business partners face similar
risks, and a security breach of their systems could adversely affect our security posture. While we continue to invest in data protection and information
technology, there can be no assurance that our efforts will prevent service interruptions, or identify breaches in our systems, that could adversely affect our
business and operations and/or result in the loss of critical or sensitive information, which could result in financial, legal, business or reputational harm.

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Our internal computer systems, or those of our collaborator, CROs or other contractors or consultants, may fail or suffer security breaches, which

could result in a material disruption of development programs for our product candidates.

Despite the implementation of security measures, our internal computer systems and those of our collaborators, CROs, and other contractors and
consultants are vulnerable to damage from computer viruses, unauthorized access, natural disasters, terrorism, war and telecommunication and electrical
failures. Information security risks have significantly increased in recent years in part due to the proliferation of new technologies and the increased
sophistication and activities of organized crime, hackers, terrorists and other external parties, including foreign state actors. As cyber threats continue to
evolve, we may be required to expend significant additional resources to continue to modify or enhance our protective measures or to investigate and
remediate any information security breaches.

While we have not experienced any such system failure, accident or security breach to date, if such an event were to occur and cause interruptions in

our operations, it could result in a material disruption of our independent drug development programs. For example, the loss of clinical trial data from
ongoing or future clinical trials for any of our product candidates could result in delays in regulatory approval efforts and significantly increase costs to
recover or reproduce the data. Our information security systems are also subject to laws and regulations requiring that we take measures to protect the privacy
and security of certain information we gather and use in our business. For example, HIPAA and its implementing regulations impose, among other
requirements, certain regulatory and contractual requirements regarding the privacy and security of personal health information. In addition to HIPAA,
numerous other federal and state laws, including, without limitation, state security breach notification laws, state health information privacy laws and federal
and state consumer protection laws, govern the collection, use, disclosure and storage of personal information. To the extent that any disruption or security
breach were to result in a loss of or damage to data or applications, or inappropriate disclosure of confidential or proprietary information or personal health
information, we could incur substantial liability, our reputation would be damaged, and the further development of our product candidates could be delayed.

Risks related to intellectual property and other legal matters

Our rights to develop and commercialize our products are subject in part to the terms and conditions of licenses or sublicenses granted to us by other

pharmaceutical companies.

Our rights to our product portfolio are based in part on patents and other intellectual property licensed from third-parties. These third parties may

generally terminate the license agreements under certain circumstances, including a material breach of the agreement by the other. In the event we terminate
our license, or if the third-party terminates our license due to our breach, rights to the intellectual property revert back to the licensor. Any termination or
reversion of our rights to develop or commercialize our products would have a material adverse effect on our business.

If our efforts to protect the proprietary nature of the intellectual property related to our products are not adequate, we may not be able to compete

effectively in our markets.

Method of treatment patents protect the use of a product for the method specified in the patent claims. This type of patent does not prevent a
competitor from making and marketing a product that is identical to our product for a use that is outside the scope of the patented method. Moreover, even if
competitors do not actively promote their product for our patented methods, physicians may prescribe these products “off-label.” Although off-label
prescriptions may infringe or contribute to the infringement of method of treatment patents, such infringement may be difficult to prevent.

Our patents and patent applications may be challenged or fail to result in issued patents and our existing or future patents may be too narrow to

prevent third parties from developing or designing around these patents. In addition, we generally rely on trade secret protection and confidentiality
agreements to protect certain proprietary know-how that is not patentable, for processes for which patents are difficult to enforce and for any other elements
of our drug development processes that involve proprietary know-how, information and technology that is not covered by patent applications. While we
require all of our employees, consultants, advisors and any third parties who have access to our proprietary know-how, information and technology to enter
into confidentiality agreements, we cannot be certain that this know-how, information and technology will not be disclosed or that competitors will not
otherwise gain access to our trade secrets or independently develop substantially equivalent information and techniques. Further, the laws of some foreign
countries do not protect proprietary rights to the same extent as the laws of the U.S. As a result, we may encounter significant problems in protecting and
defending our intellectual property both in the U.S. and abroad. If we are unable to protect or defend the intellectual property related to our technologies, we
will not be able to establish or maintain a competitive advantage in our market.

Even if our patent applications issue as patents, they may not issue in a form that will provide us with any meaningful protection, prevent

competitors from competing with us or otherwise provide us with any competitive advantage. Our

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competitors may be able to circumvent our owned or licensed patents by developing similar or alternative technologies or products in a non-infringing
manner. Our competitors may seek to market generic versions of any approved products by submitting ANDAs to the FDA in which they claim that patents
owned or licensed by us are invalid, unenforceable and/or not infringed. Alternatively, our competitors may seek approval to market their own products
similar to or otherwise competitive with our products. In these circumstances, we may need to defend and/or assert our patents, including by filing lawsuits
alleging patent infringement. In any of these types of proceedings, a court or other agency with jurisdiction may find our patents invalid and/or unenforceable.
Even if we have valid and enforceable patents, these patents still may not provide protection against competing products or processes sufficient to achieve our
business objectives.

The issuance of a patent is not conclusive as to its inventorship, scope, validity or enforceability, and our owned and licensed patents may be

challenged in the courts or patent offices in the U.S. and abroad. Such challenges may result in loss of exclusivity or freedom to operate or in patent claims
being narrowed, invalidated or held unenforceable, in whole or in part, which could limit our ability to stop others from using or commercializing similar or
identical technology and products, or limit the duration of the patent protection of our technology and products. In addition, given the amount of time required
for the development, testing and regulatory review of new product candidates, patents protecting such candidates might expire before or shortly after such
candidates are commercialized.

We are, have been, and may continue to be, involved in lawsuits to protect or enforce our patents, which could be expensive, time-consuming and

unsuccessful, and third parties may challenge the validity or enforceability of our patents and they may be successful.

Even where laws provide protection or we are able to obtain patents, costly and time-consuming litigation may be necessary to enforce and

determine the scope of our proprietary rights, and the outcome of such litigation would be uncertain. Moreover, any actions we may bring to enforce our
intellectual property against our competitors could provoke them to bring counterclaims against us, and some of our competitors have substantially greater
intellectual property portfolios than we have. To counter infringement or unauthorized use of any patents we may obtain, we may be required to file
infringement claims, which can be expensive and time-consuming to litigate. In addition, if we or one of our future collaborators were to initiate legal
proceedings against a third party to enforce a patent covering one of our products, current product candidates, or one of our future products, the defendant
could counterclaim that the patent is invalid or unenforceable. In patent litigation in the U.S., defendant counterclaims alleging invalidity or unenforceability
are commonplace and challenges to validity of patents in certain foreign jurisdictions are common as well. Grounds for a validity challenge could be an
alleged failure to meet any of several statutory requirements, including lack of novelty, obviousness, non-enablement or lack of statutory subject matter.
Grounds for an unenforceability assertion could be an allegation that someone connected with prosecution of the patent withheld relevant material
information from the U.S. Patent and Trademark Office, or made a materially misleading statement, during prosecution. We may assert the patents in Hatch-
Waxman litigation against the party filing the ANDA to keep the competing product off of the market until the patents expire but there is a risk that we will
not succeed. The party filing the ANDA may also counterclaim in the litigation that our patents are not valid or unenforceable, and the court may find one or
more claims of our patents invalid or unenforceable. If this occurs, a competing generic product could be marketed prior to expiration of our patents listed in
the FDA’s Approved Drug Products with Therapeutic Equivalence Evaluations, commonly known as the “Orange Book,” which would harm our business.

We have been and continue to be involved in number of lawsuits with a variety of generic drug manufacturers who have filed ANDAs relating to

certain of our patents. We have been successful in asserting that these third parties have infringed certain of our patents, but we may not be successful in such
lawsuits in the future. Please see Part I, Item 3, Legal Proceedings, of this Annual Report for additional information.

If we do not obtain protection under the Hatch-Waxman Act and similar foreign legislation to extend our patents and to obtain market exclusivity for

our products, our business will be harmed.

The Hatch-Waxman Act provides for an extension of patent term for drugs for a period of up to five years to compensate for time spent in
development. The HETLIOZ® U.S. new chemical entity (NCE) patent (the primary patent covering the product as a new composition of matter) received the
full five-year patent term extension under the Hatch-Waxman Act and so, assuming that we continue to have rights under our license agreement with respect
to this product, this patent in the U.S. expires in December 2022. We also own HETLIOZ® U.S. method of treatment patents (directed to the approved method
of treatment as described in the HETLIOZ® label approved by the FDA), which expire normally between 2033 and 2035, and a drug substance patent which
expires in 2035. The Fanapt® U.S. NCE patent received the full five-year patent term extension under the Hatch-Waxman Act and so this patent in the U.S.
expired in November 2016. In November 2013, a patent directed to a method of treating patients with Fanapt® based on genotype was issued to us by the
U.S. Patent and Trademark Office. This patent, which was listed in the Orange Book in January 2015, is set to expire in 2027. Please see the

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risk factor entitled “We are, have been, and may continue to be, involved in lawsuits to protect or enforce our patents, which could be expensive, time-
consuming and unsuccessful, and third parties may challenge the validity or enforceability of our patents and they may be successful,” and Part I, Item 3,
Legal Proceedings, of this Annual Report for additional information. Eight additional U.S. patents directed to methods of treating patients with Fanapt®,
which are set to expire between 2025 and 2031, were issued to us in 2015.

A directive in the E.U. provides that companies that receive regulatory approval for a new medicinal product will have a 10-year period of market
exclusivity for that product (with the possibility of a further one-year extension), beginning on the date of such European regulatory approval, regardless of
when the European NCE patent covering such product expires. A generic version of the approved drug may not be marketed or sold in Europe during such
market exclusivity period. This directive is of material importance with respect to Fanapt®, since the European NCE patent for Fanapt® has expired.

Assuming we gain a five-year patent term restoration for tradipitant, and that we continue to have rights under our license agreement with respect to
this product, we would have exclusive rights to tradipitant’s U.S. NCE patent until 2029. Assuming we gain a five-year patent term restoration for VQW-765,
and that we continue to have rights under our license agreement with respect to this product, we would have exclusive rights to VQW-765’s U.S. NCE patent
until 2028.

However, there is no assurance that we will receive the extensions of our patents or other exclusive rights available under the Hatch-Waxman Act or

similar foreign legislation. If we fail to receive such extensions or exclusive rights, our ability to prevent competitors from manufacturing, marketing and
selling generic versions of our products will be materially impaired.

We may not be successful in the development of products for our own account.

In addition to our business strategy of acquiring rights to develop and commercialize products, we may develop products for our own account by
applying our technologies to off-patent drugs as well as developing our own proprietary molecules. Because we will be funding the development of such
programs, there is a risk that we may not be able to continue to fund all such programs to completion or to provide the support necessary to perform the
clinical trials, obtain regulatory approvals or market any approved products. We expect the development of products for our own account to consume
substantial resources. If we are able to develop commercial products on our own, the risks associated with these programs may be greater than those
associated with our programs with collaborative partners.

Litigation or third-party claims of intellectual property infringement could require us to divert resources and may prevent or delay our drug discovery

and development efforts.

Our commercial success depends in part on our not infringing the patents and proprietary rights of third parties. Third parties may assert that we are
employing their proprietary technology without authorization. In addition, third parties may obtain patents in the future and claim that use of our technologies
infringes upon these patents.

Furthermore, parties making claims against us may obtain injunctive or other equitable relief, which could effectively block our ability to develop

and commercialize one or more of our products. Defense of these claims, regardless of their merit, would divert substantial financial and employee resources
from our business. In the event of a successful claim of infringement against us, we may have to pay substantial damages, obtain one or more licenses from
third parties or pay royalties. In addition, even in the absence of litigation, we may need to obtain additional licenses from third parties to advance our
research or allow commercialization of our products. We may fail to obtain any of these licenses at a reasonable cost or on reasonable terms, if at all. In that
event, we would be unable to develop and commercialize further one or more of our products.

In addition, in the future we could be required to initiate litigation to enforce our proprietary rights against infringement by third parties. Prosecution

of these claims to enforce our rights against others could divert substantial financial and employee resources from our business. If we fail to enforce our
proprietary rights against others, our business will be harmed.

As described elsewhere in these risk factors and in Part I, Item 3, Legal Proceedings, of this Annual Report, we have initiated lawsuits to enforce our

patent rights against certain generic pharmaceutical companies.

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Risks related to our common stock

Our stock price has been highly volatile and may be volatile in the future, and purchasers of our common stock could incur substantial losses.

The realization of any of the risks described in these risk factors or other unforeseen risks could have a dramatic and adverse effect on the market

price of our common stock. Between January 1, 2019 and December 31, 2019, the high and low sale prices of our common stock as reported on The Nasdaq
Global Market varied between $11.83 and $31.30. Additionally, market prices for securities of biotechnology and pharmaceutical companies, including ours,
have historically been very volatile. The market for these securities has from time to time experienced significant price and volume fluctuations for reasons
that were unrelated to the operating performance of any one company.

The following factors, in addition to the other risk factors described in this section, may also have a significant impact on the market price of our

common stock:

•

our level of success in commercializing our products;

our level of success in executing our commercialization strategies;

publicity regarding actual or potential testing or trial results relating to products under development by us or our competitors;

the outcome of regulatory review relating to products under development by us or our competitors;

regulatory developments in the U.S. and foreign countries;

developments concerning any collaboration or other strategic transaction we may undertake;

publicity regarding actual or potential litigation involving us;

announcements of patent issuances or denials, technological innovations or new commercial products by us or our competitors;

safety issues with our products or those of our competitors;

announcements of technological innovations or new therapeutic products or methods by us or others;

actual or anticipated variations in our quarterly operating results;

changes in estimates of our financial results or recommendations by securities analysts or failure to meet such financial expectations;

changes in government regulations or policies;

changes in patent legislation or patent decisions or adverse changes to patent law;

additions or departures of key personnel or members of our board of directors;

the publication of negative research or articles about our company, our business or our products by industry analysts or others;

• market rumors or press reports;

•

publicity regarding actual or potential transactions involving us; and

economic, political and other external factors beyond our control.

We have been and may in the future be subject to litigation, which could harm our stock price, business, results of operations and financial condition.

We have been the subject of litigation in the past and may be subject to litigation in the future. In the past, following periods of volatility in the

market price of their stock, many companies, including us, have been the subjects of securities class action litigation. Any such litigation can result in
substantial costs and diversion of management’s attention and resources and could harm our stock price, business results of operations and financial condition.
As a result of these factors, holders of our common stock might be unable to sell their shares at or above the price they paid for such shares.

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If there are substantial sales of our common stock, our stock price could decline.

A small number of institutional investors and private equity funds hold a significant number of shares of our common stock. Sales by these
stockholders of a substantial number of shares, or the expectation of such sales, could cause a significant reduction in the market price of our common stock.

In addition to our outstanding common stock, as of December 31, 2019, there were a total of 6,144,430 shares of our common stock that we have
registered and that we are obligated to issue upon the exercise of currently outstanding options and settlement of restricted stock unit awards granted under
our 2006 and 2016 Equity Incentive Plans. Upon the exercise of these options or settlement of the shares underlying these restricted stock units, as the case
may be, in accordance with their respective terms, these shares may be resold freely, subject to restrictions imposed on our affiliates under Rule 144. If
significant sales of these shares occur in short periods of time, these sales could reduce the market price of our common stock. Any reduction in the trading
price of our common stock could impede our ability to raise capital on attractive terms, if at all.

If securities or industry analysts do not publish research or reports or publish unfavorable research about our business, our stock price and trading

volume could decline.

The trading market for our common stock will depend in part on the research and reports that securities or industry analysts publish about us or our

business. We currently have research coverage by securities and industry analysts. If one or more of the analysts who covers us downgrades our stock, our
stock price would likely decline. If one or more of these analysts ceases coverage of our company or fails to regularly publish reports on us, interest in the
purchase of our stock could decrease, which could cause our stock price or trading volume to decline.

Our common stock may experience future dilution as a result of future equity offerings.

In order to raise additional capital, we may in the future offer additional shares of our common stock or other securities convertible into or
exchangeable for our common stock at prices that may not be the same as the price per share in previous offerings. We may sell shares or other securities in
any other offering at a price per share that is less than the price per share paid by investors in previous offerings, and investors purchasing shares or other
securities in the future could have rights superior to existing stockholders. The price per share at which we sell additional shares of our common stock, or
securities convertible or exchangeable into common stock, in future transactions may be higher or lower than the price per share paid by investors.

Our business could be negatively affected as a result of the actions of activist stockholders.

Proxy contests have been waged against many companies in the biopharmaceutical industry, including us, over the last several years. If faced with a

proxy contest or other type of shareholder activism, we may not be able to respond successfully to the contest or dispute, which would be disruptive to our
business. Even if we are successful, our business could be adversely affected by a proxy contest or shareholder dispute involving us because:

•

responding to proxy contests and other actions by activist stockholders can be costly and time-consuming, disrupting operations and diverting
the attention of management and employees;

perceived uncertainties as to future direction may result in the loss of potential acquisitions, collaborations or in-licensing opportunities, and
may make it more difficult to attract and retain qualified personnel and business partners; and

if individuals are elected to a board of directors with a specific agenda, it may adversely affect our ability to effectively and timely implement
our strategic plan and create additional value for our stockholders.

These actions could cause our stock price to experience periods of volatility.

Anti-takeover provisions in our charter and bylaws and under Delaware law, and the adoption of a rights plan, could prevent or delay a change in

control of our company.

We are a Delaware corporation and the anti-takeover provisions of Section 203 of the Delaware General Corporation Law may discourage, delay or

prevent a change in control by prohibiting us from engaging in a business combination with an interested stockholder for a period of three years after the
person becomes an interested stockholder, even if a change of control would be beneficial to our existing stockholders. In addition, our amended and restated
certificate of incorporation and bylaws may discourage, delay or prevent a change in our management or control over us that stockholders may consider
favorable. Our amended and restated certificate of incorporation and bylaws:

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•

authorize the issuance of “blank check” preferred stock that could be issued by our board of directors to thwart a takeover attempt;

do not provide for cumulative voting in the election of directors, which would allow holders of less than a majority of the stock to elect some
directors;

establish a classified board of directors, as a result of which the successors to the directors whose terms have expired will be elected to serve
from the time of election and qualification until the third annual meeting following their election;

require that directors only be removed from office for cause;

provide that vacancies on the board of directors, including newly-created directorships, may be filled only by a majority vote of directors then in
office;

limit who may call special meetings of stockholders;

prohibit stockholder action by written consent, requiring all actions to be taken at a meeting of the stockholders; and

establish advance notice requirements for nominating candidates for election to the board of directors or for proposing matters that can be acted
upon by stockholders at stockholder meetings.

Our board of directors previously adopted a rights agreement, the provisions of which could have had the effect of discouraging, delaying or

preventing a change in or management or control over us. While there is no plan to do so at this time, our board of directors may choose to adopt a new
rights plan in the future.

Global economic conditions may have an adverse effect on our business.

Financial instability or a general decline in economic conditions in the U.S. and other countries where we sell our product could adversely affect our

operations. Economic conditions, and uncertainty as to the general direction of the macroeconomic environment, are beyond our control and may make any
necessary debt or equity financing more difficult, more costly, and more dilutive. While we believe we have adequate capital resources to meet current
working capital and capital expenditure requirements, an economic downturn or significant increase in our expenses could require additional financing on less
than attractive rates or on terms that are excessively dilutive to existing stockholders. Failure to secure any necessary financing in a timely manner and on
favorable terms could have a material adverse effect on our stock price and could require us to delay or abandon clinical development plans.

Sales of our products will be dependent, in large part, on reimbursement from government health administration authorities, private health insurers,
distribution partners and other organizations. In the event of economic decline, these organizations may be unable to satisfy their reimbursement obligations
or may delay payment. In addition, federal and state health authorities may reduce Medicare and Medicaid reimbursements, and private insurers may increase
their scrutiny of claims. A reduction in the availability or extent of reimbursement could negatively affect our product sales and revenue.

In addition, we rely on third parties for several important aspects of our business. For example, we use third parties for sales, distribution, medical

affairs and clinical research, and we rely upon several single source providers of raw materials and contract manufacturers for the manufacture of our
products. During challenging and uncertain economic times and in tight credit markets, there may be a disruption or delay in the performance of our third
party contractors, suppliers or partners. If such third parties are unable to satisfy their commitments to us, our business and results of operations would be
adversely affected.

ITEM 1B.

UNRESOLVED STAFF COMMENTS

Not applicable.

ITEM 2.

PROPERTIES

Our headquarters office consists of a total of 43,462 square feet of office space located at 2200 Pennsylvania Avenue, N.W. in Washington, D.C.

under operating leases and subleases that expire between 2026 and 2028 and are subject to renewal options. In addition, we have 2,880 square feet of office
space in London, England under an operating lease that has a lease

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term ending in 2021 and is subject to a renewal option, and other short term leases. We believe that these facilities are suitable and adequate to meet our
anticipated near-term needs. We anticipate that following the expiration of the leases, additional or alternative space will be available at commercially
reasonable terms.

ITEM 3.

LEGAL PROCEEDINGS

Fanapt®. We have been involved in litigation with Roxane Laboratories, Inc. (Roxane) and its affiliates, West-Ward Pharmaceuticals International
Limited and West-Ward Pharmaceuticals Corp (West-Ward), since we filed a lawsuit against Roxane in the U.S. District Court for the District of Delaware
(Delaware District Court) for patent infringement in June 2014. The lawsuit was filed in response to Roxane’s submission to the U.S. Food and Drug
Administration (FDA) of an Abbreviated New Drug Application (ANDA) for a generic version of Fanapt® prior to the expiration of certain of our patents
covering Fanapt®, including U.S. Patent No. 8,586,610 (‘610 Patent). In August 2016, the Delaware District Court ruled in our favor, permanently enjoining
Roxane from manufacturing, using, selling, offering to sell, distributing or importing any generic iloperidone product described in Roxane’s ANDA until the
expiration of the ‘610 Patent in November 2027, or May 2028 if we obtain pediatric exclusivity. In April 2018, following an appeal by Roxane of the
Delaware District Court’s decision to the Federal Circuit Court of Appeals (Federal Circuit), the Federal Circuit affirmed the Delaware District Court’s ruling.
In June 2018, West-Ward, having replaced Roxane as defendants following the acquisition of Roxane by West-Ward’s parent company, Hikma
Pharmaceuticals PLC, petitioned the Federal Circuit for a rehearing en banc. In August 2018, the Federal Circuit denied West-Ward's petition. In January
2019, West-Ward filed a petition in the U.S. Supreme Court for a writ of certiorari seeking reversal of the Federal Circuit’s decision. In March 2019, the U.S.
Supreme Court invited the Solicitor General of the U.S. to file a brief in the matter expressing the views of the U.S. In January 2020, the U.S. Supreme Court
denied West-Ward's petition for writ of certiorari.

In 2015, we filed six separate patent infringement lawsuits in the Delaware District Court against Roxane, Inventia Healthcare Pvt. Ltd. (Inventia),
Lupin Ltd. and Lupin Pharmaceuticals, Inc. (Lupin), Taro Pharmaceuticals USA, Inc. and Taro Pharmaceutical Industries, Ltd. (Taro), and Apotex Inc. and
Apotex Corp. (Apotex, and collectively with Roxane, Inventia, Lupin and Taro, the Fanapt® Defendants). These lawsuits were filed in response to the
submission to the FDA by each of the Fanapt® Defendants of ANDAs for generic versions of Fanapt® prior to the expiration of the ‘610 Patent in November
2027 or the U.S. Patent No. 9,138,432 in September 2025. We entered into separate confidential stipulations with each of Inventia and Lupin regarding any
potential launch of their generic versions of Fanapt®. The parties are scheduled to provide the court with a status report in March 2020 with respect to the
remaining lawsuits against the other Fanapt® Defendants.

HETLIOZ®. In April and May 2018, we filed three separate patent infringement lawsuits in the Delaware District Court against Teva

Pharmaceuticals USA, Inc. (Teva), MSN Pharmaceuticals Inc. and MSN Laboratories Private Limited (MSN) and Apotex (collectively with Teva and MSN,
the HETLIOZ® Defendants) after having received Paragraph IV certification notice letters (Paragraph IV Letters) from each of the HETLIOZ® Defendants
alleging that certain of our patents covering HETLIOZ® (collectively, the HETLIOZ® Patents) were invalid, unenforceable and/or would not be infringed by
the manufacture, use or sale of their generic versions of HETLIOZ®, as described in the ANDAs submitted to the FDA by each of the HETLIOZ®
Defendants, prior to the expiration of the latest to expire of the HETLIOZ® Patents in 2034. Each of the HETLIOZ® Patents are listed in the Approved Drug
Products with Therapeutic Equivalence Evaluations (Orange Book). In December 2018, we filed amended complaints against each of the HETLIOZ®
Defendants following the receipt of additional Paragraph IV Letters from Teva and Apotex concerning our Orange Book listed '977 Patent, which expires in
2035. These lawsuits are scheduled for trial in October 2020.

In March 2019, April 2019, and May 2019, we filed three additional patent infringement lawsuits in the Delaware District Court against the
HETLIOZ® Defendants following the receipt of additional Paragraph IV Letters from each concerning our Orange Book listed U.S. Patent No. 10,149,829,
which expires in 2033. These lawsuits have been consolidated with the other lawsuits against the HETLIOZ® Defendants and are also scheduled for trial in
October 2020.

In November and December 2019, we filed additional patent infringement lawsuits in the Delaware District Court against Apotex and Teva,

respectively, for infringement of our Orange Book listed U.S. Patent No. 10,376,487 ('487 Patent) following the receipt of additional Paragraph IV Letters
from Apotex and Teva regarding the '487 Patent, which expires in July 2035. Teva asserted a counterclaim for a declaratory judgment that the ‘487 Patent is
invalid. We answered Teva’s counterclaim by denying their allegation that the ‘487 Patent is invalid. In January 2020, we filed two additional patent
infringement lawsuits in the Delaware District Court against Teva and Apotex for infringement of our Orange Book-listed U.S. Patent No. 10,449,176 (‘176
Patent) following the receipt of additional Paragraph IV Letters from Teva and Apotex regarding the ‘176 Patent, which expires in January 2033. A trial date
has not yet been scheduled for these lawsuits.

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In January 2020, we received an additional Paragraph IV Letter from MSN concerning the '487 patent, in which MSN alleges that the ‘487 Patent is

invalid, unenforceable and/or will not be infringed by the commercial manufacture, use, sale offer for sale, or importation of MSN's generic version of
HETLIOZ® as described in MSN's ANDA. We intend to vigorously pursue a patent infringement lawsuit permanently enjoining MSN from infringing the
claims of the ‘487 Patent.

Other Matters. In April 2018, we submitted a protocol amendment to the FDA, proposing a 52-week open-label extension (OLE) period for patients

who had completed the tradipitant Phase II clinical study (2301) in gastroparesis. In May 2018, based on feedback from the FDA, we amended the protocol
limiting the duration of treatment in the 2301 study to a total of three months, while continuing to seek further dialogue with the FDA on extending the study
duration to 52-weeks. As a part of this negotiation process, in September 2018, we submitted a new follow-on 52-week OLE protocol to the FDA (2302) for
patients who had completed the 2301 study. While waiting for further feedback, we did not enroll any patients in any study beyond 12 weeks. In December
2018, the FDA imposed a partial clinical hold (PCH) on the two proposed studies, stating that we are required first to conduct additional chronic toxicity
studies in canines, monkeys or minipigs before allowing patients access in any clinical protocol beyond 12 weeks. At that time, the FDA informed us that the
original PCH was not based on any safety or efficacy data related to tradipitant, but, rather, that these additional toxicity studies were required by a guidance
document. Subsequently, the FDA has taken the position that an additional study was required in order for the FDA to have adequate toxicology data to
undertake a risk analysis of tradipitant.

In February 2019, a qui tam action filed against us was unsealed by order of the DC District Court. The qui tam action, which was filed under seal in
March 2017, was brought by a former employee of ours on behalf of the U.S., 28 states and the District of Columbia (collectively, the Plaintiff States) and the
policyholders of certain insurance companies under the Federal False Claims Act and state law equivalents to the Federal False Claims Act and related state
laws. The complaint alleged that we violated these laws through the promotion and marketing of our products Fanapt® and HETLIOZ® and sought, among
other things, treble damages, civil penalties for each alleged false claim, and attorneys’ fees and costs. By virtue of the DC District Court having unsealed the
original complaint, we learned that in January 2019, the U.S. Department of Justice (the DOJ), as well as the Plaintiff States, elected not to intervene in the
qui tam action at that time. In May 2019, the plaintiff filed an amended complaint under seal repeating the same allegations and seeking the same relief.
According to a filing unsealed in June 2019, the DOJ reaffirmed its decision not to intervene and incorporated its prior filing, indicating that neither the DOJ
nor the Plaintiff States were intervening regarding the original complaint. Although the DOJ and the Plaintiff States have elected not to intervene, the plaintiff
may litigate this action and the DOJ and the Plaintiff States may later seek to intervene in the action. In August 2019, we filed a motion to dismiss, and in
October 2019 the plaintiff filed a reply. We intend to vigorously defend ourselves in the case. The Court will hear our motion to dismiss on March 20, 2020.

In February 2019, a securities class action, Gordon v. Vanda Pharmaceuticals Inc., was filed in the U.S. District Court for the Eastern District of

New York naming us and certain of our officers as defendants. An amended complaint was filed in July 2019. The amended complaint, filed on behalf of a
purported stockholder, asserts claims on behalf of a putative class of all persons who purchased our publicly traded securities between November 4, 2015 and
February 11, 2019, for alleged violations of Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule 10b-5 promulgated
thereunder. The amended complaint alleges that the defendants made false and misleading statements and/or omissions regarding Fanapt®, HETLIOZ® and
our interactions with the FDA regarding tradipitant between November 3, 2015 and February 11, 2019. We believe that we have meritorious defenses and
intend to vigorously defend this lawsuit. We do not anticipate that this litigation will have a material adverse effect on our business, results of operations or
financial condition. However, this lawsuit is subject to inherent uncertainties, the actual cost may be significant, and we may not prevail. We believe we are
entitled to coverage under our relevant insurance policies, subject to a retention, but coverage could be denied or prove to be insufficient.

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In July 2019, a shareholder derivative complaint, Samuel Williams vs. Mihael Polymeropoulos, et al., was filed in the U.S. District Court for the
Eastern District of New York naming certain of our current and former directors and officers as defendants. In September 2019, a shareholder derivative
complaint, Michael Bavaro v. Mihael Polymeropoulos, et al., was filed in the Delaware District Court naming certain of our current and former directors and
officers as defendants. In October 2019, we filed a motion to transfer the Bavaro case to the Eastern District of New York, where the Gordon and Williams
cases are pending. In February 2020, the Delaware District Court issued an order staying the Bavaro case pending the resolution of the Williams case. These
complaints, filed on behalf of purported stockholders, derivatively on our behalf, assert claims for alleged breach of fiduciary duties by certain of our current
and former directors and officers. We believe that we have meritorious defenses and intend to vigorously defend these lawsuits. We do not anticipate that this
litigation will have a material adverse effect on our business, results of operations or financial condition. However, these lawsuits are subject to inherent
uncertainties, the actual cost may be significant, and we may not prevail. We believe we are entitled to coverage under our relevant insurance policies, subject
to a retention, but coverage could be denied or prove to be insufficient.

In July 2017, the CHMP issued a negative opinion recommending against approval of Fanaptum® (oral iloperidone tablets) for the treatment of

schizophrenia in adult patients in the E.U. The CHMP was of the opinion that the benefits of Fanaptum® did not outweigh its risks and recommended against
marketing authorization. In March 2018, we filed an application seeking annulment of the EMA’s negative opinion and the subsequent European Commission
decision refusing marketing authorization of Fanaptum in the European General Court. In December 2019, the General Court issued its judgment dismissing
the action, leaving the EMA opinion and Commission decision intact. We are considering our options to appeal the decision.

ITEM 4.

MINE SAFETY DISCLOSURES

Not applicable.

PART II

ITEM 5.

MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES
OF EQUITY SECURITIES

Our common stock is quoted on The Nasdaq Global Market under the symbol “VNDA.” As of February 18, 2020, there were seven holders of record

of our common stock. The number of holders of record of our common stock does not reflect the number of beneficial holders whose shares are held by
depositors, brokers or other nominees.

Market Price of and Dividends on the Registrant’s Common Equity and Related Stockholder Matters

The following graph shows the cumulative five-year total return on our common stock relative to the cumulative total returns of the Nasdaq
Composite Index and the Nasdaq Biotechnology Index. An investment of $100 (with reinvestment of dividends) is assumed to have been made in our
common stock and in each of the indexes on December 31, 2014 and its relative performance is tracked through December 31, 2019. The comparisons in the
table are required by the Securities and Exchange Commission (SEC) and are not intended to forecast or be indicative of possible future performance of our
common stock. We have never paid cash dividends to our stockholders and do not plan to pay dividends in the foreseeable future. The following graph and
related information is being furnished solely to accompany this Annual Report pursuant to Item 201(e) of Regulation S-K and shall not be deemed “soliciting
materials” or to be “filed” with the SEC (other than as provided in Item 201), nor shall such information be incorporated by reference into any of our filings
under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date hereof, and
irrespective of any general incorporation language in any such filing.

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Securities Authorized for Issuance under Equity Incentive Plans

Information regarding securities authorized for issuance under equity incentive plans will be contained in our Proxy Statement for the 2020 Annual

Meeting of Stockholders to be filed with the SEC within 120 days after the end of the fiscal year ended December 31, 2019, under the caption “Security
Ownership of Certain Beneficial Owners and Management” and is incorporated herein by reference pursuant to General Instruction G(3) to Form 10-K.

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ITEM 6.

SELECTED CONSOLIDATED FINANCIAL DATA

The consolidated statements of operations data for the years ended December 31, 2019, 2018 and 2017 and the consolidated balance sheet data as of

December 31, 2019 and 2018 are each derived from our audited consolidated financial statements included in this Annual Report. The consolidated
statements of operations data for the years ended December 31, 2016 and 2015, and the consolidated balance sheet data as of December 31, 2017, 2016 and
2015 are each derived from our audited consolidated financial statements not included herein. Our historical results for any prior period are not necessarily
indicative of results to be expected in any future period.

The following data should be read together with our consolidated financial statements and accompanying notes and the section entitled

Management’s Discussion and Analysis of Financial Condition and Results of Operations included in this Annual Report.

(in thousands, except for share and per share amounts)

2019 (1)

2018 (1)(2)

2017 (1)(2)

2016 (1)(2)

2015 (1)(2)

Year Ended December 31,

Statements of Operations Data

Total revenues

Operating expenses:

Cost of goods sold excluding amortization

Research and development

Selling, general and administrative

Intangible asset amortization

Total operating expenses

Income (loss) from operations

Other income

Income (loss) before income taxes

Provision (benefit) for income taxes

Net income (loss)

Net income (loss) per share:

Basic

Diluted

Weighted average shares outstanding:

Basic

Diluted

(in thousands)
Balance Sheet Data

Cash and cash equivalents

Marketable securities

Working capital

Total assets

Long-term liabilities

Total liabilities

Accumulated deficit

Total stockholders’ equity

227,188 $

193,118 $

165,083 $

146,017 $

109,925

24,488

48,649

129,736

1,505

204,378

22,810

6,218

29,028

(86,525)

20,508

43,594

105,751

1,527

171,380

21,738

3,608

25,346

138

17,848

38,547

123,841

1,750

181,986

(16,903)

1,472

(15,431)

136

24,712

29,156

99,787

10,933

164,588

(18,571)

665

(17,906)

104

23,462

29,145

84,531

12,972

150,110

(40,185)

320

(39,865)

—

115,553 $

25,208 $

(15,567) $

(18,010) $

(39,865)

2.17 $

2.11 $

0.50 $

0.48 $

(0.35) $

(0.41) $

(0.94)

53,137,562

50,859,947

44,735,146

43,449,441

54,847,060

53,045,257

44,735,146

43,449,441

42,250,254

2019 (1)

2018 (1)

2017 (1)

2016 (1)

2015 (1)

December 31,

45,072 $

61,005 $

33,627 $

40,426 $

267,057

294,631

483,748

13,298

72,803

(220,665)

410,945

196,355

246,117

332,130

3,693

56,708

(336,218)

275,422

109,786

99,494

205,425

3,675

74,038

(361,426)

131,387

100,914

123,855

210,374

28,724

79,044

(345,859)

131,330

50,843

92,337

115,230

213,050

28,706

80,023

(327,849)

133,027

(1)

(2)

We adopted Accounting Standards Codification (ASC) Subtopic 842 Leases (ASC 842), effective January 1, 2019, using a modified retrospective
transition. Results for the years ended prior to December 31, 2019 are accounted for in accordance with ASC 840.

We adopted Accounting Standards Codification (ASC) Subtopic 606 Revenue from Contracts with Customers (ASC 606), effective January 1, 2018,
using the modified retrospective method to those contracts which were not completed

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as of January 1, 2018. Results for the years ended prior to December 31, 2018 are accounted for in accordance with ASC 605.

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ITEM 7.

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

You should read the following discussion and analysis of our financial condition and results of operations together with Selected Consolidated
Financial Data and our consolidated financial statements and related notes appearing in this annual report on Form 10-K (Annual Report). Some of the
information contained in this discussion and analysis or set forth elsewhere in this Annual Report include historical information and other information with
respect to our plans and strategy for our business and contain forward-looking statements that involve risks, uncertainties and assumptions. Our actual
results may differ materially from those anticipated in these forward-looking statements as a result of certain factors, including but not limited to those set
forth under the “Risk Factors” section of this report and elsewhere in this Annual Report.

Overview

Vanda Pharmaceuticals Inc. (we, our or Vanda) is a leading global biopharmaceutical company focused on the development and commercialization

of innovative therapies to address high unmet medical needs and improve the lives of patients.

We strive to advance novel approaches to bring important, new medicines to market through responsible innovation. We are committed to the use of

technologies that support sound science, including genetics and genomics, in drug discovery, clinical trials and the commercial positioning of our products.

Our commercial portfolio is currently comprised of two products, HETLIOZ® for the treatment of Non-24-Hour Sleep-Wake Disorder (Non-24) and

Fanapt® for the treatment of schizophrenia. HETLIOZ® is the first treatment for Non-24 approved by the FDA. In addition, we have a number of drugs in
development, including:

•

HETLIOZ® (tasimelteon) for the treatment of jet lag disorder, Smith-Magenis Syndrome (SMS), pediatric Non-24 and delayed sleep phase disorder
(DSPD);

Fanapt® (iloperidone) for the treatment of bipolar disorder and a long acting injectable (LAI) formulation program for the treatment of
schizophrenia;

Tradipitant (VLY-686), a small molecule neurokinin-1 receptor (NK-1R) antagonist, for the treatment of atopic dermatitis, gastroparesis and motion
sickness;

VTR-297, a small molecule histone deacetylase (HDAC) inhibitor for the treatment of hematologic malignancies and with potential use as a
treatment for several oncology indications;

VQW-765, a small molecule nicotinic acetylcholine receptor partial agonist, with potential use for the treatment of psychiatric disorders; and

Operational Highlights

Tradipitant

•

Results from the EPIONE study of tradipitant in the treatment of pruritus in atopic dermatitis were reported today. We will reassess EPIONE 2 and
determine next steps.

Enrollment in the Phase III study of tradipitant in gastroparesis (VP-VLY-686-3301) is ongoing.

• We expect to complete the Phase III program of tradipitant in motion sickness and file an NDA with the FDA in 2020.

• We continue to engage with the FDA over the requirement of a nine-month dog toxicity study.

HETLIOZ®

• We submitted an sNDA for HETLIOZ® in SMS, including data for a liquid formulation, and expect regulatory action by the FDA in 2020.

• We continue to pursue approval for HETLIOZ® in the treatment of jet lag disorder.

•

A clinical program for HETLIOZ® in DSPD is ongoing.

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Fanapt®

•

A Phase III study of Fanapt® in bipolar disorder is ongoing.

Development of the LAI formulation of Fanapt® is ongoing.

Since we began operations, we have devoted substantially all of our resources to the in-licensing, clinical development and commercialization of our

products. Our ability to generate meaningful product sales and achieve profitability largely depends on our level of success in commercializing HETLIOZ®
and Fanapt® in the U.S. and Europe, on our ability, alone or with others, to complete the development of our products, and to obtain the regulatory approvals
for and to manufacture, market and sell our products. The results of our operations will vary significantly from year-to-year and quarter-to-quarter and depend
on a number of factors, including risks related to our business, risks related to our industry, and other risks which are detailed in Risk Factors reported in
Item 1A of Part I of this Annual Report.

As described in Part I, Item 3, Legal Proceedings, of this Annual Report, we have initiated lawsuits to enforce our patent rights against certain

generic pharmaceutical companies.

Critical Accounting Policies

The preparation of our consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and
liabilities and the disclosure of contingent assets and liabilities at the date of our financial statements, as well as the reported revenues and expenses during the
reported periods. We base our estimates on historical experience and on various other factors that we believe are reasonable under the circumstances, the
results of which form the basis for making judgments about the carrying value of assets and liabilities that are not apparent from other sources. Actual results
may differ from these estimates under different assumptions or conditions.

A summary of our significant accounting policies appears in the notes to our audited consolidated financial statements for the year ended

December 31, 2019 included in this Annual Report. However, we believe that the following accounting policies are important to understanding and evaluating
our reported financial results, and we have accordingly included them in this discussion.

Leases. In accordance with Accounting Standards Codification (ASC) 842, Leases, effective January 1, 2019, we determine if an arrangement

contains a lease at inception. Right-of-use (ROU) assets represent our right to use an underlying asset for the lease term and lease liabilities represent our
obligation to make lease payments arising from that lease. For leases with a term greater than 12 months, ROU assets and liabilities are recognized at the
lease commencement date based on the estimated present value of lease payments over the lease term. The lease term includes the option to extend the lease
when it is reasonably certain we will exercise that option. We do not combine lease and non-lease elements for office leases. For existing leases as of January
1, 2019, executory costs are excluded from lease expense, which is consistent with our accounting under ASC 840, Leases. For all leases entered into after
January 1, 2019, executory costs are allocated between lease and non-lease elements based upon their relative stand-alone prices.

When available, we use the rate implicit in the lease to discount lease payments to present value; however, most of our leases do not provide a
readily determinable implicit rate. Therefore, we use our incremental borrowing rate based on information available at the lease commencement date in
determining the present value of lease payments. Our incremental borrowing rate is derived from information available at the lease commencement date in
determining the present value of lease payments. Since we do not have outstanding debt that could provide an indication of the appropriate discount rate we
used publicly available data for instruments with similar characteristics when calculating our incremental borrowing rates. In making this estimation we
considered market comparable data on companies with similar credit rating, secured contracts and contract length terms. We use the lease term to determine
the incremental borrowing rate.

Net Product Sales. Our net product sales consist of sales of HETLIOZ® and sales of Fanapt®. In accordance with ASC Subtopic 606 Revenue from

Contracts with Customers (ASC 606), which we adopted January 1, 2018, we account for a contract when it has approval and commitment from both parties,
the rights of the parties are identified, payment terms are identified, the contract has commercial substance and collectability of consideration is probable. We
recognize revenue when control of the product is transferred to the customer in an amount that reflects the consideration we expect to be entitled to in
exchange for those product sales, which is typically once the product physically arrives at the customer. Sales taxes, value add taxes, and usage-based taxes
are excluded from revenues.

HETLIOZ® is available in the U.S. for distribution through a limited number of specialty pharmacies, and is not available in retail pharmacies.

Fanapt® is available in the U.S. for distribution through a limited number of wholesalers and is

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available in retail pharmacies. We invoice and record revenue when customers, specialty pharmacies and wholesalers, receive product from the third-party
logistics warehouse which is the point at which control is transferred to the customer. Revenues and accounts receivable are concentrated with these
customers. Outside the U.S., we commercially launched HETLIOZ® in Germany in August 2016. We have also entered into a distribution agreement with
Megapharm Ltd. for the commercialization of Fanapt® in Israel. The Company evaluates outstanding receivables to assess collectability. In performing this
evaluation, the Company analyzes economic conditions, the aging of receivables and customer specific risks.

The transaction price is determined based upon the consideration to which we will be entitled in exchange for transferring product to the customer.
Our product sales are recorded net of applicable product revenue allowances for which reserves are established and include discounts, rebates, chargebacks,
service fees, co-pay assistance and product returns that are applicable for various government and commercial payors. We estimate the amount of variable
consideration that should be included in the transaction price utilizing the most likely amount method and update our estimate at each reporting date. Variable
consideration is included in the transaction price if, in our judgment, it is probable that a significant future reversal of cumulative revenue under the contract
will not occur. Allowances for rebates, chargebacks and co-pay assistance are based upon the insurance benefits of the end customer, which are estimated
using historical activity and, where available, actual and pending prescriptions for which we have validated the insurance benefits. Reserves for variable
consideration are classified as product revenue allowances on the consolidated balance sheets, with the exception of prompt-pay discounts which are
classified as reductions of accounts receivable. The reserve for product returns for which the product may not be returned for a period of greater than one year
from the balance sheet date is included as a component of other non-current liabilities in the consolidated balance sheets. Uncertainties related to variable
consideration are generally resolved in the quarter subsequent to period end, with the exception of Medicaid rebates, which are dependent upon the timing of
when states submit reimbursement claims, and product returns which are resolved during the product expiry period specified in the customer contract. We
currently record sales allowances for the following:

Prompt-pay: Specialty pharmacies and wholesalers are offered discounts for prompt payment. We expect that the specialty pharmacies and wholesalers
will earn prompt payment discounts and, therefore, deduct the full amount of these discounts from total product sales when revenues are recognized.

Rebates: Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program as well as contracted rebate programs with other
payors. Rebate amounts owed after the final dispensing of the product to a benefit plan participant are based upon contractual agreements or legal
requirements with public sector benefit providers, such as Medicaid. The allowance for rebates is based on statutory or contracted discount rates and
estimated patient utilization.

Chargebacks: Chargebacks are discounts that occur when contracted indirect customers purchase directly from specialty pharmacies and wholesalers.
Contracted indirect customers, which currently consist primarily of Public Health Service institutions, non-profit clinics, and federal government entities
purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The specialty pharmacy or wholesaler, in turn, charges
back the difference between the price initially paid by the specialty pharmacy or wholesaler and the discounted price paid to the specialty pharmacy or
wholesaler by the contracted customer.

Medicare Part D Coverage Gap: Medicare Part D prescription drug benefit mandates manufacturers to fund approximately 50% of the Medicare Part D
insurance coverage gap for prescription drugs sold to eligible patients through 2018. Public Law No. 115-123, also known as the Bipartisan Budget Act
of 2018 enacted on February 9, 2018 increased the manufacturer discount from 50% to 70% effective in 2019 for applicable drugs. We account for the
Medicare Part D coverage gap using a point of sale model. Estimates for expected Medicare Part D coverage gap are based in part on historical activity
and, where available, actual and pending prescriptions when we have validated the insurance benefits.

Service Fees: We receive sales order management, data and distribution services from certain customers. These fees are based on contracted terms and
are known amounts. We accrue service fees at the time of revenue recognition, resulting in a reduction of product sales and the recognition of an accrued
liability, unless it is a payment for a distinct good or service from the customer in which case the fair value of those distinct goods or services are
recorded as selling, general and administrative expense.

Co-payment Assistance: Patients who have commercial insurance and meet certain eligibility requirements may receive co-payment assistance. Co-pay
assistance utilization is based on information provided by our third-party administrator.

Product Returns: We generally offer direct customers a limited right to return as contractually defined with our customers. We consider several factors in
the estimation process, including expiration dates of product shipped to customers, inventory levels within the distribution channel, product shelf life,
historical return activity, including activity for product sold for which the return period has past, prescription trends and other relevant factors. We do not
expect returned goods to be resalable. There was no right of return asset as of December 31, 2019 or 2018.

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The following table summarizes sales discounts and allowance activity as of and for the years ended December 31, 2019, 2018 and 2017:

(in thousands)
Balances at December 31, 2016

Provision related to current period sales

Adjustments for prior period sales

Credits/payments made

Balances at December 31, 2017

Provision related to current period sales

Adjustments for prior period sales

Credits/payments made

Balances at December 31, 2018

Provision related to current period sales

Adjustments for prior period sales

Credits/payments made

Balances at December 31, 2019

Rebates &
Chargebacks

Discounts,
Returns
and Other

Total

31,202 $

6,458 $

53,406

(3,883)

(60,496)

20,229

59,317

811

(58,223)

22,134

59,358

(350)

(58,750)

23,751

1,362

(24,214)

7,357

23,796

370

(21,823)

9,700

26,872

(399)

(26,022)

22,392 $

10,151 $

37,660

77,157

(2,521)

(84,710)

27,586

83,113

1,181

(80,046)

31,834

86,230

(749)

(84,772)

32,543

The provision for rebates and chargebacks of $59.4 million and $59.3 million for the years ended December 31, 2019 and 2018, respectively,

primarily represents Medicaid rebates applicable to sales of Fanapt® and HETLIOZ®. The provision for discounts, returns and other of $26.9 million and
$23.8 million for the years ended December 31, 2019 and 2018, primarily represents wholesaler distribution fees applicable to sales of Fanapt® and, to a
lesser extent, estimated product returns of Fanapt®, as well as co-pay assistance costs and prompt pay discounts applicable to the sales of both HETLIOZ® and
Fanapt®.

Stock-based compensation. Compensation costs for all stock-based awards to employees and directors are measured based on the grant date fair

value of those awards and recognized over the period during which the employee or director is required to perform service in exchange for the award. We use
the Black-Scholes-Merton option pricing model to determine the fair value of stock options. The determination of the fair value of stock options on the date
of grant using an option pricing model is affected by our stock price as well as assumptions regarding a number of complex and subjective variables. These
variables include the expected stock price volatility over the expected term of the awards, actual and projected employee stock option exercise behaviors,
risk-free interest rate and expected dividends. Expected volatility rates are based on the historical volatility of our publicly traded common stock and other
factors. The risk-free interest rates are based on the U.S. Treasury yield for a period consistent with the expected term of the option in effect at the time of the
grant. We have never paid cash dividends to our stockholders and do not plan to pay dividends in the foreseeable future. As stock-based compensation
expense recognized in the consolidated statements of operations is based on awards ultimately expected to vest, it has been reduced for estimated forfeitures.
Forfeitures are estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.

Research and development expenses. Research and development expenses consist primarily of fees for services provided by third parties in
connection with the clinical trials, costs of contract manufacturing services for clinical trial use, milestone payments made under licensing agreements prior to
regulatory approval, costs of materials used in clinical trials and research and development, costs for regulatory consultants and filings, depreciation of capital
resources used to develop products, related facilities costs, and salaries, other employee-related costs and stock-based compensation for research and
development personnel. We expense research and development costs as they are incurred for products in the development stage, including manufacturing
costs and milestone payments made under license agreements prior to FDA approval. Upon and subsequent to FDA approval, manufacturing and milestone
payments made under license agreements are capitalized. Milestone payments are accrued when it is deemed probable that the milestone event will be
achieved. Costs related to the acquisition of intellectual property are expensed as incurred if the underlying technology is developed in connection with our
research and development efforts and has no alternative future use.

Clinical trials are inherently complex, often involve multiple service providers, and can include payments made to investigator physicians at study

sites. Because billing for services often lags delivery of service by a substantial amount of time, we often are required to estimate a significant portion of our
accrued clinical expenses. Our assessments include, but are not

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limited to: (i) an evaluation by the project manager of the work that has been completed during the period, (ii) measurement of progress prepared internally
and/or provided by the third-party service provider, (iii) analyses of data that justify the progress, and (iv) management’s judgment. In the event that we do
not identify certain costs that have begun to be incurred or we under- or over-estimates the level of services performed or the costs of such services, our
reported expenses for such period would be too low or too high.

Intangible Assets. Our intangible assets consist of capitalized license costs for products approved by the FDA. We amortize our intangible assets on a

straight-line basis over the estimated useful economic life of the related product patents. We assess the impairment of intangible assets whenever events or
changes in circumstances indicate that the carrying value may not be recoverable. Factors we consider important which could trigger an impairment review
include significant underperformance relative to expected historical or projected future operating results, a significant adverse change in legal or regulatory
factors that could affect the value or patent life including our ability to defend and enforce patent claims and other intellectual property rights and significant
negative industry or economic trends. When we determine that the carrying value of our intangible assets may not be recoverable based upon the existence of
one or more of the indicators of impairment, we measure any impairment based on the amount that carrying value exceeds fair value. No impairments have
been recognized on our intangible assets.

Income taxes. We assess the need for a valuation allowance against our deferred tax asset each quarter through the review of all available positive

and negative evidence. Deferred tax assets are reduced by a tax valuation allowance when, in the opinion of management, it is more likely than not that some
portion of the deferred tax assets will not be realized. The analysis is highly dependent upon historical and projected taxable income. Projected taxable
income includes significant assumptions related to revenue, commercial expenses and research and development activities. During 2019, after considering all
available positive and negative evidence, including but not limited to cumulative income in recent periods, historical, current and future projected results and
significant risks and uncertainties related to forecasts, we concluded that it was more likely than not that substantially all of our deferred tax assets in the U.S.
are realizable in future periods. A valuation allowance has been retained against certain U.S. federal tax attributes with short carryforward periods and District
of Columbia state deferred tax assets as of December 31, 2019. A full valuation allowance was recorded against all net U.S. deferred tax assets as of
December 31, 2018. Tax benefits are recognized from an uncertain tax position only if it is more likely than not that the tax position will be sustained on
examination by the taxing authorities based on the technical merits of the position. The tax benefit recognized in the financial statements for a particular tax
position is based on the largest benefit that is more likely than not to be realized upon settlement.

Recent Accounting Pronouncements

See Note 2, Summary of Significant Accounting Policies, to the consolidated financial statements included in Part II of this Annual Report for

information on recent accounting pronouncements.

Results of Operations

We anticipate that our results of operations will fluctuate for the foreseeable future due to several factors, including our and our partners’ ability to
successfully commercialize our products, any possible payments made or received pursuant to license or collaboration agreements, progress of our research
and development efforts, the timing and outcome of clinical trials and related possible regulatory approvals. Since our inception, we have incurred significant
losses resulting in an accumulated deficit of $220.7 million as of December 31, 2019. Our total stockholders’ equity was $410.9 million as of December 31,
2019.

Year ended December 31, 2019 compared to year ended December 31, 2018

Revenues. Total revenues increased by $34.1 million, or 18%, to $227.2 million for the year ended December 31, 2019 compared to $193.1 million

for the year ended December 31, 2018. Revenues were as follows:

(in thousands)
HETLIOZ® product sales, net
Fanapt® product sales, net
Total net product sales

Year Ended December 31,

2019

2018

142,980 $

115,835 $

84,208

77,283

227,188 $

193,118 $

Net
Change

Percent

27,145

6,925

34,070

23%

18%

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HETLIOZ® product sales, net increased by $27.1 million, or 23%, to $143.0 million for the year ended December 31, 2019 compared to $115.8
million for the year ended December 31, 2018. The increase to net product sales was attributable to an increase in volume and an increase in price net of
deductions.

Fanapt® product sales, net increased by $6.9 million, or 9%, to $84.2 million for the year ended December 31, 2019 compared to $77.3 million for

the year ended December 31, 2018. The increase to net product sales was attributable to an increase in price net of deductions.

Cost of goods sold. Cost of goods sold increased by $4.0 million, or 19%, to $24.5 million for the year ended December 31, 2019 compared to $20.5

million for the year ended December 31, 2018. Cost of goods sold includes third party manufacturing costs of product sold, third party royalty costs and
distribution and other costs. Third party royalty costs were 10% and 5% of net product sales of HETLIOZ® in the U.S. and Germany, respectively, and 9% of
net product sales of Fanapt®. Third party royalty costs on net product sales of Fanapt® will decrease to 6% beginning January 2020.

In addition to third party royalty costs, HETLIOZ® and Fanapt® cost of goods sold as a percentage of revenue depends upon our cost to manufacture
inventory at normalized production levels with our third party manufacturers. We expect that, in the future, total HETLIOZ® manufacturing costs included in
cost of goods sold will continue to be less than 2% of our net HETLIOZ® product sales. We expect that, in the future, total U.S. Fanapt® manufacturing costs
included in cost of goods sold will continue to be less than 3% of our net U.S. Fanapt® product sales.

Research and development expenses. Research and development expenses increased by $5.1 million, or 12%, to $48.6 million for the year ended

December 31, 2019 compared to $43.6 million for the year ended December 31, 2018. The increase was primarily due to an increase in clinical trial expenses
associated with the tradipitant and Fanapt programs as well as an increase in indirect project costs including stock-based compensation expense, partially
offset by a decrease in expenses associated with the HETLIOZ® clinical programs.

The following table summarizes the costs of our product development initiatives for the years ended December 31, 2019 and 2018.

(in thousands)
Direct project costs (1)
HETLIOZ®
Fanapt®
Tradipitant

VTR-297

CFTR

Other

Indirect project costs (1)

Stock-based compensation

Other indirect overhead

Year Ended December 31,

2019

2018

8,672 $

5,516

21,290

1,609

4,511

668

42,266

3,207

3,176

6,383

Total research and development expense

48,649 $

12,709

3,438

16,978

2,190

3,870

619

39,804

1,290

2,500

3,790

43,594

(1) We record direct costs, including personnel costs and related benefits, on a project-by-project basis. Many of our research and development costs are
not attributable to any individual project because we share resources across several development projects. We record indirect costs that support a
number of our research and development activities in the aggregate, including stock-based compensation.

We expect to incur significant research and development expenses as we continue to develop our products. In addition, we expect to incur licensing

costs in the future that could be substantial, as we continue our efforts to expand our product pipeline.

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Selling, general and administrative expenses. Selling, general and administrative expenses increased by $24.0 million, or 23%, to $129.7 million for
the year ended December 31, 2019 compared to $105.8 million for the year ended December 31, 2018. The increase was primarily the result of higher spend
on legal and corporate related activities, including personnel costs, and Non-24 direct to consumer marketing.

Intangible asset amortization. Intangible asset amortization was $1.5 million for each of the years ended December 31, 2019 and 2018.

Other income. Other income was $6.2 million for the year ended December 31, 2019 compared to $3.6 million for the year ended December 31,

2018. Other income primarily relates to investment income on our marketable securities.

Provision for income taxes. An income tax benefit of $86.5 million was recorded for the year ended December 31, 2019 and a provision for income

taxes of $0.1 million was recorded for the year ended December 31, 2018. The income tax benefit for 2019 was primarily due to the reduction of the tax
valuation allowance against substantially all of its deferred tax assets in the U.S. Tax expense associated with U.S. income before income taxes for the years
ended December 31, 2019 and 2018 was offset by a corresponding tax benefit for the reduction of the valuation allowance recorded against tax attributes that
were utilized in those periods. Income tax expense was recorded related to certain U.S. state and foreign jurisdictions for the years ended December 31, 2019
and 2018.

Liquidity and Capital Resources

As of December 31, 2019, our total cash and cash equivalents and marketable securities were $312.1 million compared to $257.4 million at
December 31, 2018. Our cash and cash equivalents are deposits in operating accounts and highly liquid investments with an original maturity of 90 days or
less at date of purchase and consist of investments in money market funds with commercial banks and financial institutions, and commercial paper of high-
quality corporate issuers. Our marketable securities consist of investments in government sponsored and corporate enterprises and commercial paper.

Our liquidity resources as of December 31, 2019 and 2018 are summarized as follows:

(in thousands)
Cash and cash equivalents

Marketable securities:

U.S. Treasury and government agencies

Corporate debt

Asset-backed securities

Total marketable securities

Total cash, cash equivalents and marketable securities

December 31, 2019

December 31, 2018

45,072 $

61,005

88,601

130,055

48,401

267,057

312,129 $

69,270

105,910

21,175

196,355

257,360

As of December 31, 2019, we maintained all of our Cash in two financial institutions. Deposits held with these institutions may exceed the amount

of insurance provided on such deposits, but we do not anticipate any losses with respect to such deposits.

We expect to incur substantial costs and expenses throughout 2020 and beyond in connection with our continued clinical development of tradipitant
and our other products, U.S. commercial activities for HETLIOZ® and Fanapt®, the European commercial launch activities for HETLIOZ® and payments due
upon achievement of milestones under our license agreements. Additionally, we continue to pursue market approval of HETLIOZ® and Fanapt® in other
regions. The actual costs to advance tradipitant and our research and development projects and commercial activities for HETLIOZ® and Fanapt® are difficult
to estimate and may vary significantly. We believe that our existing funds will be sufficient to meet our operating plans for at least the next twelve months.
Our future capital requirements and the adequacy of our available funds will depend on many factors, primarily including our ability to generate revenue, the
scope and costs of our commercial, manufacturing and process development activities, the magnitude of our discovery, preclinical and clinical development
programs, and potential costs to acquire or license the rights to additional products.

We may need or desire to obtain additional capital to finance our operations through debt, equity or alternative financing arrangements. We may also
seek capital through collaborations or partnerships with other companies. The issuance of debt could require us to grant liens on certain of our assets that may
limit our flexibility and debt securities may be convertible

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into common stock. If we raise additional capital by issuing equity securities, the terms and prices for these financings may be much more favorable to the
new investors than the terms obtained by our existing stockholders. These financings also may significantly dilute the ownership of our existing stockholders.
If we are unable to obtain additional financing, we may be required to reduce the scope of our future activities which could harm our business, financial
condition and operating results. There can be no assurance that any additional financing required in the future will be available on acceptable terms, if at all.

Cash Flow

The following table summarizes our net cash flows from operating, investing and financing activities for the years ended December 31, 2019 and

2018:

(in thousands)
Net cash provided by (used in):

Operating activities:

Net income

Non-cash charges

Net change in operating assets and liabilities

Operating activities

Investing activities:

Acquisition of intangible asset

Purchases of property and equipment

Net purchases of marketable securities

Investing activities

Financing activities:

Net proceeds from offering of common stock

Proceeds from exercise of employee stock options and other

Financing activities

Effect of exchange rate changes on cash, cash equivalents and restricted cash

Net increase (decrease) in cash, cash equivalents and restricted cash

Year Ended December 31,

2019

2018

Net Change

115,553 $

25,208 $

(72,731)

3,125

45,947

—

(1,019)

(67,290)

(68,309)

—

6,264

(1)

12,568

(7,790)

29,986

(25,000)

(368)

(84,292)

(109,660)

90,345

(85,299)

10,915

15,961

25,000

(651)

17,002

41,351

100,870

(100,870)

6,256

107,126

(100,862)

(38)

(16,099) $

27,414 $

(43,513)

Operating Activities. Cash flows provided by operating activities during the year ended December 31, 2019 were $45.9 million, an increase of $16.0

million compared to $30.0 million during the year ended December 31, 2018. The increase reflects an increase of $90.3 million in net income and $10.9
million from the net change in operating assets and liabilities, partially offset by a decrease of $85.3 million in non-cash charges primarily due to the
reduction of our tax valuation allowance against substantially all of our deferred tax assets in the U.S. The increase of $10.9 million from the net change in
operating assets and liabilities primarily relates to a decrease in accounts receivable attributable to the timing of shipments and payments and an increase in
accounts payable and other liabilities attributable to the timing of activities and payments.

Investing Activities. Cash flows used in investing activities during the year ended December 31, 2019 were $68.3 million, a decrease of $41.4 million

compared to $109.7 million during the year ended December 31, 2018. Investing activities reflect continued net reinvestment of available cash and cash
equivalents in our portfolio of marketable securities. Additionally, during the year ended December 31, 2018, we paid $25.0 million upon achievement of a
HETLIOZ® milestone obligation.

Financing Activities. Cash flows provided by financing activities during the year ended December 31, 2019 were $6.3 million, a decrease of $100.9
million compared to $107.1 million during the year ended December 31, 2018. During the year ended December 31, 2018, we received net cash proceeds of
$100.9 million from a public offering of common stock.

Off-balance sheet arrangements

We have no off-balance sheet arrangements, as defined in Item 303(a)(4) of the Securities and Exchange Commission’s Regulation S-K.

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Contractual obligations and commitments

The following is a summary of our non-cancellable long-term contractual cash obligations as of December 31, 2019:

(in thousands)
Operating leases (1)

Purchase commitments (2)

Total

2020

2021

2022

2023

2024

Thereafter

20,103 $

2,326 $

2,332 $

2,355 $

2,420 $

2,488 $

10,614

9,167

966

481

—

30,717 $

11,493 $

3,298 $

2,836 $

2,420 $

2,488 $

8,182

—

8,182

Cash payments due by year (3)(4)

(1) Operating leases include the minimum lease payments for our operating lease liabilities. This table does not include obligations under short-term lease
agreements, variable payments for building maintenance and other services and executory costs associated with our operating lease agreements.

(2) Purchase commitments include noncancellable purchase commitments for agreements longer than one year and primarily relate to commitments for

media and data services. This table does not include various other long-term agreements entered into for services with other third party vendors, such as
inventory purchase commitments, due to the cancelable nature of the services or variable terms within the agreement. Additionally, this table does not
include rebates, chargebacks or discounts recorded as liabilities at the time that product sales are recognized as revenue.

(3) This table does not include potential future milestone obligations under our license agreements for which we have not deemed it probable that the

milestone event will occur as of December 31, 2019. See Part I, Item 1, Business, of this Annual Report, for a description of our licensing arrangements
and remaining milestone obligations.

(4) This table does not include liabilities related to uncertain tax positions taken as of December 31, 2019. Due to the uncertainties in the timing of potential

tax audits, the timing associated with the resolution of these positions is also uncertain.

ITEM 7A.

QUALITATIVE AND QUANTITATIVE DISCLOSURES ABOUT MARKET RISK

Interest rate risks

Our exposure to market risk is currently confined to our cash and cash equivalents, marketable securities and restricted cash. We currently do not
hedge interest rate exposure. We have not used derivative financial instruments for speculation or trading purposes. Because of the short-term maturities of
our cash and cash equivalents and marketable securities, we do not believe that an increase in market rates would have any significant impact on the realized
value of our investments.

Concentrations of credit risk

We deposit our cash with financial institutions that we consider to be of high credit quality and purchase marketable securities which are generally

investment grade, liquid, short-term fixed income securities and money-market instruments denominated in U.S. dollars. Our marketable securities consist of
commercial paper, corporate notes, asset-backed securities and U.S. government agency notes.

Revenues and accounts receivable are concentrated with specialty pharmacies and wholesalers. There were 5 major customers that each accounted

for more than 10% of total revenues and, as a group, represented 96% of total revenues for the year ended December 31, 2019. There were 5 major customers
that each accounted for more than 10% of accounts receivable and, as a group, represented 94% of total accounts receivable at December 31, 2019. We
mitigate our credit risk relating to accounts receivable from customers by performing ongoing credit evaluations.

Foreign currency risk

We are exposed to risks related to changes in foreign currency exchange rates relating to our foreign operations. The functional currency of our

international subsidiaries is the local currency. We are exposed to foreign currency risk to the extent that we enter into transactions denominated in currencies
other than our subsidiaries’ respective functional currencies. We are also exposed to unfavorable fluctuations of the U.S. dollar, which is our reporting
currency, against the currencies of our operating subsidiaries when their respective financial statements are translated into U.S. dollars for inclusion in our

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consolidated financial statements. We do not currently hedge our foreign currency exchange rate risk. Foreign currency has not had a material impact on our
results of operations.

Effects of inflation

Inflation has not had a material impact on our results of operations.

ITEM 8.

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The consolidated financial statements and related financial statement schedules required to be filed are listed in the Index to Consolidated Financial

Statements and are incorporated in Item 15 of Part IV of this Annual Report.

ITEM 9.

CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

None.

ITEM 9A.

CONTROLS AND PROCEDURES

Conclusion Regarding the Effectiveness of Disclosure Controls and Procedures

Under the supervision and with the participation of our management, including the Chief Executive Officer and Chief Financial Officer, we

evaluated the effectiveness of the design and operation of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the
Securities and Exchange Act of 1934 (Exchange Act)) as of December 31, 2019. Based upon that evaluation, our Chief Executive Officer and Chief Financial
Officer concluded that our disclosure controls and procedures are effective as of December 31, 2019, the end of the period covered by this Annual Report, to
ensure that the information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and
reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management,
including our Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosures.

Management’s Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining an adequate system of internal control over financial reporting, as defined in the

Exchange Act Rule 13a-15(f). Management conducted an assessment of our internal control over financial reporting based on the original framework
established in 2013 by the Committee of Sponsoring Organizations of the Treadway Commission in Internal Control — Integrated Framework. Based on the
assessment, management concluded that, as of December 31, 2019, our internal control over financial reporting was effective. The effectiveness of our
internal control over financial reporting as of December 31, 2019 has been audited by PricewaterhouseCoopers LLP, an independent registered public
accounting firm, as stated in their report included in this Annual Report.

Changes in Internal Control over Financial Reporting

There has been no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act)

during the fourth quarter of 2019 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

ITEM 9B.

OTHER INFORMATION

None.

PART III

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ITEM 10.

DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

Information required under this item will be contained in our Proxy Statement for the 2020 Annual Meeting of Stockholders to be filed with the SEC

within 120 days after the end of the fiscal year ended December 31, 2019, under the captions “Election of Directors,” “Executive Officers,” “Corporate
Governance,” and “Section 16(a) Beneficial Ownership Reporting Compliance” and is incorporated herein by reference pursuant to General Instruction G(3)
to Form 10-K.

ITEM 11.

EXECUTIVE COMPENSATION

Information required under this item will be contained in our Proxy Statement for the 2020 Annual Meeting of Stockholders to be filed with the SEC

within 120 days after the end of the fiscal year ended December 31, 2019, under the captions “Corporate Governance” and “Compensation of Executive
Officers,” and is incorporated herein by reference pursuant to General Instruction G(3) to Form 10-K, except that information required by Item 407(e)(5) of
Regulation S-K will be deemed furnished in this Form 10-K and will not be deemed incorporated by reference into any filing under the Securities Act of
1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent that we specifically incorporate it by reference into such filing.

ITEM 12.

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER
MATTERS

Information required under this item will be contained in our Proxy Statement for the 2020 Annual Meeting of Stockholders to be filed with the SEC

within 120 days after the end of the fiscal year ended December 31, 2019, under the caption “Security Ownership of Certain Beneficial Owners and
Management” and is incorporated herein by reference pursuant to General Instruction G(3) to Form 10-K.

ITEM 13.

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE

Information required under this item will be contained in our Proxy Statement for the 2020 Annual Meeting of Stockholders to be filed with the SEC
within 120 days after the end of the fiscal year ended December 31, 2019, under the caption “Corporate Governance” and is incorporated herein by reference
pursuant to General Instruction G(3) to Form 10-K.

ITEM 14.

PRINCIPAL ACCOUNTANT FEES AND SERVICES

Information required under this item will be contained in our Proxy Statement for the 2020 Annual Meeting of Stockholders to be filed with the SEC

within 120 days after the end of the fiscal year ended December 31, 2019, under the caption “Ratification of Selection of Independent Registered Public
Accounting Firm” and is incorporated herein by reference pursuant to General Instruction G (3) to Form 10-K.

ITEM 15.

EXHIBITS AND FINANCIAL STATEMENTS SCHEDULES

PART IV

The consolidated financial statements filed as part of this annual report on Form 10-K are listed in the Index to Consolidated Financial Statements.
Certain schedules are omitted because they are not applicable, or not required, or because the required information is included in the consolidated financial
statements or notes thereto. The Exhibits are listed in the Exhibit Index.

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Signatures

Pursuant to the requirements of Section 13 and 15(d) of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this annual

report on Form 10-K to be signed on its behalf by the undersigned, thereunto duly authorized.

Vanda Pharmaceuticals Inc.

February 26, 2020

By:

/s/ Mihael H. Polymeropoulos, M.D.

Mihael H. Polymeropoulos, M.D.

President and Chief Executive Officer

Pursuant to the requirements of the Securities Act of 1934, this annual report on Form 10-K has been signed below by the following persons on

behalf of the registrant and in the capacities and on the dates indicated.

Name

Title

Date

/s/ Mihael H. Polymeropoulos, M.D.

Mihael H. Polymeropoulos, M.D.

President and Chief Executive Officer and Director
(principal executive officer)

February 26, 2020

/s/ James P. Kelly

James P. Kelly

Executive Vice President, Chief Financial Officer
and Treasurer (principal financial
officer and principal accounting officer)

/s/ H. Thomas Watkins

H. Thomas Watkins

/s/ Anne Sempowski Ward

Anne Sempowski Ward

/s/ Phaedra Chrousos

Phaedra Chrousos

/s/ Richard W. Dugan

Richard W. Dugan

Stephen Ray Mitchell

Chairman of the Board and
Director

Director

February 26, 2020

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Vanda Pharmaceuticals Inc.

Index to Consolidated Financial Statements

Report of Independent Registered Public Accounting Firm

Consolidated Balance Sheets at December 31, 2019 and 2018

Consolidated Statements of Operations for the years ended December 31, 2019, 2018 and 2017

Consolidated Statements of Comprehensive Income (Loss) for the years ended December 31, 2019, 2018 and 2017

Consolidated Statements of Changes in Stockholders’ Equity for the years ended December 31, 2019, 2018 and 2017

Consolidated Statements of Cash Flows for the years ended December 31, 2019, 2018 and 2017

Notes to the Consolidated Financial Statements

Page

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Report of Independent Registered Public Accounting Firm

To the Board of Directors and Stockholders of Vanda Pharmaceuticals Inc.

Opinions on the Financial Statements and Internal Control over Financial Reporting

We have audited the accompanying consolidated balance sheets of Vanda Pharmaceuticals Inc. and its subsidiaries (the “Company”) as of December 31, 2019
and 2018, and the related consolidated statements of operations, of comprehensive income (loss), of changes in stockholders’ equity and of cash flows for
each of the three years in the period ended December 31, 2019, including the related notes (collectively referred to as the “consolidated financial statements”).
We also have audited the Company's internal control over financial reporting as of December 31, 2019, based on criteria established in Internal Control -
Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO).

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of the Company as of
December 31, 2019 and 2018, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2019 in
conformity with accounting principles generally accepted in the United States of America. Also in our opinion, the Company maintained, in all material
respects, effective internal control over financial reporting as of December 31, 2019, based on criteria established in Internal Control - Integrated Framework
(2013) issued by the COSO.

Change in Accounting Principle

As discussed in Note 2 to the consolidated financial statements, the Company changed the manner in which it accounts for leases in 2019.

Basis for Opinions

The Company's management is responsible for these consolidated financial statements, for maintaining effective internal control over financial reporting, and
for its assessment of the effectiveness of internal control over financial reporting, included in Management’s Report on Internal Control over Financial
Reporting appearing under Item 9A. Our responsibility is to express opinions on the Company’s consolidated financial statements and on the Company's
internal control over financial reporting based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight
Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the
applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain reasonable
assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud, and whether effective internal
control over financial reporting was maintained in all material respects.

Our audits of the consolidated financial statements included performing procedures to assess the risks of material misstatement of the consolidated financial
statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis,
evidence regarding the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles used
and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. Our audit of internal
control over financial reporting included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness
exists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audits also included performing
such other procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinions.

Definition and Limitations of Internal Control over Financial Reporting

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and
the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over
financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect
the transactions and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions are recorded as necessary to

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permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are
being made only in accordance with authorizations of management and directors of the company; and (iii) provide reasonable assurance regarding prevention
or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of
effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance
with the policies or procedures may deteriorate.

Critical Audit Matters

The critical audit matters communicated below are matters arising from the current period audit of the consolidated financial statements that were
communicated or required to be communicated to the audit committee and that (i) relate to accounts or disclosures that are material to the consolidated
financial statements and (ii) involved our especially challenging, subjective, or complex judgments. The communication of critical audit matters does not alter
in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by communicating the critical audit matters below,
providing separate opinions on the critical audit matters or on the accounts or disclosures to which they relate.

Medicaid rebates

As described in Note 2 to the consolidated financial statements, allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program
as well as contracted rebate programs with other payors. Rebate amounts owed after the final dispensing of the product to a benefit plan participant are based
upon contractual agreements or legal requirements with public sector benefit providers, such as Medicaid. The allowance for rebates is based on statutory or
contracted discount rates and estimated patient utilization. The Company has recorded product revenue allowances of $31.9 million as of December 31, 2019,
of which a significant amount relates to allowances for Medicaid rebates.

The principal considerations for our determination that performing procedures relating to Medicaid rebates is a critical audit matter are there was significant
judgment by management due to the significant measurement uncertainty involved in developing the allowances, as these allowances are based on
assumptions developed for estimated patient utilization, primarily payor mix, invoice lag and inventory levels within the distribution channel. This in turn led
to a high degree of auditor judgment, subjectivity and effort in performing procedures and evaluating audit evidence related to management’s significant
assumptions, related to the estimated patient utilization.

Addressing the matter involved performing procedures and evaluating audit evidence in connection with forming our overall opinion on the consolidated
financial statements. These procedures included testing the effectiveness of controls relating to the allowances for Medicaid rebates, including controls over
the assumptions used to estimate these rebates. These procedures also included, among others, (i) developing an independent estimate of the Medicaid rebates
by utilizing third-party information related to payor mix, as well as inventory levels within the distribution channel and the historical trends of the invoice lag;
(ii) comparing the independent estimate to management’s estimate; and (iii) testing rebate claims processed by the Company, including evaluating those
claims for consistency with the contractual and mandated terms of the Medicaid Drug Rebate Program.

Product Returns for Fanapt

As described in Note 2 to the consolidated financial statements, the Company generally offers direct customers a limited right to return as contractually
defined with the customers. The Company has recorded a reserve for product returns for Fanapt of $6.1 million as of December 31, 2019. Management
considers several factors in the estimation process, including expiration dates of product shipped to customers, inventory levels within the distribution
channel, product shelf life, historical return activity including activity for product sold for which the return period has past, prescription trends and other
relevant factors. Management does not expect returned goods to be resalable.

The principal considerations for our determination that performing procedures relating to the product returns for Fanapt is a critical audit matter are there was
significant judgment by management due to the significant measurement uncertainty involved in developing the reserve, as the reserve is based on
assumptions developed using return activity with limited historical information and inventory levels within the distribution channel. This in turn led to a high
degree of auditor judgment, subjectivity and effort in performing procedures relating to these significant assumptions, and evaluating audit evidence relating
to the reserve for product returns for Fanapt.

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Valuation Allowance for Deferred Tax Assets

As described in Note 15 to the consolidated financial statements, the Company has recorded a valuation allowance on deferred tax assets of $8.2 million as of
December 31, 2019. For the year ended December 31, 2019, the Company recorded income tax benefit of $86.5 million. The income tax benefit for 2019 was
primarily due to the reduction of the Company's tax valuation allowance against substantially all of its deferred tax assets in the U.S. Management assesses
the need for a valuation allowance against its deferred tax asset each quarter through the review of all available positive and negative evidence. Deferred tax
assets are reduced by a tax valuation allowance when, in the opinion of management, it is more likely than not that some portion of the deferred tax assets will
not be realized. Management’s analysis depends on historical and projected taxable income. Projected taxable income includes significant assumptions related
to revenue, commercial expenses and research and development activities.

The principal considerations for our determination that performing procedures relating to the valuation allowance for deferred tax assets is a critical audit
matter are there was significant judgment by management due to the significant measurement uncertainty involved in determining the realizability of the
deferred tax assets, as realizability is based on historical taxable income and projected taxable income, specifically related to assumptions developed for
projected revenue, commercial expenses and research and development activities. This in turn led to a high degree of auditor judgment, subjectivity and effort
in performing procedures related to evaluating management’s judgments about the Company’s ability to realize deferred tax assets, including the evaluation of
significant assumptions related to the realizability of deferred tax assets, and evaluating audit evidence relating to assumptions for projected revenue,
commercial expenses and research and development activities.

Addressing the matter involved performing procedures and evaluating audit evidence in connection with forming our overall opinion on the consolidated
financial statements. These procedures included testing the effectiveness of controls relating to the valuation allowance for deferred tax assets, including
controls over the assessment of the need for valuation allowances. These procedures also included, among others, (i) testing management’s process for
developing projected taxable income; (ii) evaluating the appropriateness of the method for estimating projected taxable income; (iii) testing the completeness,
accuracy, and relevance of underlying data used in the estimate; and (iv) evaluating the significant assumptions used by management to estimate projected
revenue, commercial expenses and research and development activities. Evaluating management’s assumptions involved evaluating whether the assumptions
used by management were reasonable considering (i) the current and past performance of the company, (ii) the consistency with external market and industry
data, and (iii) whether these assumptions were consistent with evidence obtained in other areas of the audit.

/s/ PricewaterhouseCoopers LLP

Baltimore, Maryland
February 26, 2020

We have served as the Company’s auditor since 2003.

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VANDA PHARMACEUTICALS INC.
CONSOLIDATED BALANCE SHEETS

(in thousands, except for share and per share amounts)
ASSETS

Current assets:

Cash and cash equivalents

Marketable securities

Accounts receivable, net

Inventory

Prepaid expenses and other current assets

Total current assets

Property and equipment, net

Operating lease right-of-use assets

Intangible assets, net

Deferred tax assets

Non-current inventory and other

Total assets

LIABILITIES AND STOCKHOLDERS’ EQUITY

Current liabilities:

Accounts payable and accrued liabilities

Product revenue allowances

Milestone obligations under license agreements

Total current liabilities

Operating lease non-current liabilities

Other non-current liabilities

Total liabilities

Commitments and contingencies (Notes 10 and 17)

Stockholders’ equity:

Preferred stock, $0.001 par value; 20,000,000 shares authorized, and no shares issued or outstanding

Common stock, $0.001 par value; 150,000,000 shares authorized; 53,549,612 and 52,477,593 shares
issued and outstanding at December 31, 2019 and 2018, respectively

Additional paid-in capital

Accumulated other comprehensive income

Accumulated deficit

Total stockholders’ equity

Total liabilities and stockholders’ equity

December 31, 2019

December 31, 2018

45,072 $

267,057

26,367

1,140

14,500

354,136

3,864

11,180

23,037

87,680

3,851

61,005

196,355

28,780

994

11,998

299,132

4,417

—

24,542

—

4,039

483,748 $

332,130

27,590 $

31,915

—

59,505

12,455

843

72,803

—

631,307

249

(220,665)

410,945

21,584

31,231

200

53,015

—

3,693

56,708

—

611,587

(336,218)

275,422

332,130

483,748 $

The accompanying notes are an integral part of these consolidated financial statements.

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(in thousands, except for share and per share amounts)
Revenues:

Net product sales

Total revenues

Operating expenses:

Cost of goods sold excluding amortization

Research and development

Selling, general and administrative

Intangible asset amortization

Total operating expenses

Income (loss) from operations

Other income

Income (loss) before income taxes

Provision (benefit) for income taxes

Net income (loss)

Net income (loss) per share:

Basic

Diluted

Weighted average shares outstanding:

Basic

Diluted

VANDA PHARMACEUTICALS INC.
CONSOLIDATED STATEMENTS OF OPERATIONS

Year Ended December 31,

2019

2018

2017

227,188 $

193,118 $

227,188

193,118

24,488

48,649

129,736

1,505

204,378

22,810

6,218

29,028

(86,525)

20,508

43,594

105,751

1,527

171,380

21,738

3,608

25,346

138

165,083

17,848

38,547

123,841

1,750

181,986

(16,903)

1,472

(15,431)

136

115,553

25,208

(15,567)

2.17 $

2.11 $

0.50 $

0.48 $

(0.35)

53,137,562

50,859,947

54,847,060

53,045,257

44,735,146

The accompanying notes are an integral part of these consolidated financial statements.

VANDA PHARMACEUTICALS INC.
CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)

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(in thousands)
Net income (loss)

Other comprehensive income (loss):

Net foreign currency translation gain (loss)

Change in net unrealized gain (loss) on marketable securities

Tax provision on other comprehensive income

Other comprehensive income (loss), net of tax

Comprehensive income (loss)

Year Ended December 31,

2019

2018

2017

115,553 $

25,208 $

(15,567)

313

(71)

248

(22)

—

(122)

—

(92)

115,801

25,243

(15,659)

The accompanying notes are an integral part of these consolidated financial statements.

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VANDA PHARMACEUTICALS INC.
CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY

Common Stock

Par Value

Additional
Paid-in Capital

Other
Comprehensive
Income (Loss)

Accumulated
Deficit

Total

44,000,614 $

44 $

477,087 $

58 $

(345,859) $

131,330

(in thousands, except for share amounts)
Balances at December 31, 2016

Issuance of common stock from the

exercise of stock options and settlement
of restricted stock units

Stock-based compensation expense

Net loss

Other comprehensive loss, net of tax

Net proceeds from public offering of

common stock

Issuance of common stock from the

exercise of stock options and settlement
of restricted stock units

Stock-based compensation expense

Net income

Other comprehensive income, net of tax

937,519

—

1,214,460

—

Balances at December 31, 2017

44,938,133

Balances at December 31, 2018

52,477,593

Issuance of common stock from the

exercise of stock options and settlement
of restricted stock units

Stock-based compensation expense

Net income

Other comprehensive income, net of tax

1,072,019

—

6,325,000

100,864

—

5,250

10,465

—

492,802

—

6,255

11,666

—

611,587

6,262

13,458

—

(92)

(34)

—

248

—

(15,567)

—

(361,426)

5,251

10,465

(15,567)

(92)

131,387

—

100,870

—

25,208

—

6,256

11,666

25,208

(336,218)

275,422

—

115,553

—

6,264

13,458

115,553

248

Balances at December 31, 2019

53,549,612

631,307

249

(220,665)

410,945

The accompanying notes are an integral part of these consolidated financial statements.

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VANDA PHARMACEUTICALS INC.
CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)
Cash flows from operating activities

Net income (loss)

Adjustments to reconcile net income (loss) to net cash provided by (used in) operating
activities:

Depreciation of property and equipment

Stock-based compensation

Amortization of discounts and premiums on marketable securities

Intangible asset amortization

Deferred income taxes

Other non-cash adjustments, net

Changes in operating assets and liabilities:

Accounts receivable

Prepaid expenses and other assets

Inventory

Accounts payable and other liabilities

Product revenue allowances

Net cash provided by (used in) operating activities

Cash flows from investing activities

Acquisition of intangible asset

Purchases of property and equipment

Purchases of marketable securities

Maturities of marketable securities

Net cash used in investing activities

Cash flows from financing activities

Net proceeds from offering of common stock

Proceeds from exercise of employee stock options

Net cash provided by financing activities

Effect of exchange rate changes on cash, cash equivalents and restricted cash

Net increase (decrease) in cash, cash equivalents and restricted cash

Cash, cash equivalents and restricted cash

Beginning of year

End of year

Year Ended December 31,

2019

2018

2017

115,553 $

25,208 $

(15,567)

1,387

13,458

(3,099)

1,505

(87,767)

1,785

2,342

(2,764)

(722)

3,508

761

45,947

—

(1,019)

(394,517)

327,227

(68,309)

—

6,264

(1)

(16,099)

1,429

11,666

(2,221)

1,527

—

167

(11,207)

(4,258)

(618)

8,223

29,986

(25,000)

(368)

(282,395)

198,103

(109,660)

100,870

6,256

107,126

(38)

27,414

61,749

45,650

34,335

61,749

1,234

10,465

(426)

1,750

—

587

2,525

3,652

(1,060)

5,953

(11,096)

(1,983)

—

(1,664)

(148,135)

139,568

(10,231)

—

5,251

(6,921)

41,256

34,335

The accompanying notes are an integral part of these consolidated financial statements.

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1. Business Organization and Presentation

Business organization

VANDA PHARMACEUTICALS INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

Vanda Pharmaceuticals Inc. (the Company) is a leading global biopharmaceutical company focused on the development and commercialization of

innovative therapies to address high unmet medical needs and improve the lives of patients. The Company commenced its operations in 2003 and operates in
one reporting segment.

The Company's commercial portfolio is currently comprised of two products, HETLIOZ® for the treatment of Non-24-Hour Sleep-Wake Disorder
(Non-24) and Fanapt® for the treatment of schizophrenia. HETLIOZ® is the first treatment for Non-24 approved by the U.S. Food and Drug Administration
(FDA). In addition, the Company has a number of drugs in development, including:

•

HETLIOZ® (tasimelteon) for the treatment of jet lag disorder, Smith-Magenis Syndrome (SMS), pediatric Non-24 and delayed sleep phase
disorder (DSPD);

Fanapt® (iloperidone) for the treatment of bipolar disorder and a long acting injectable (LAI) formulation program for the treatment of
schizophrenia;

Tradipitant (VLY-686), a small molecule neurokinin-1 receptor (NK-1R) antagonist, for the treatment of atopic dermatitis, gastroparesis and
motion sickness;

VTR-297, a small molecule histone deacetylase (HDAC) inhibitor for the treatment of hematologic malignancies and with potential use as a
treatment for several oncology indications;

VQW-765, a small molecule nicotinic acetylcholine receptor partial agonist, with potential use for the treatment of psychiatric disorders; and

Basis of Presentation

The accompanying consolidated financial statements includes the accounts of Vanda Pharmaceuticals Inc. and its wholly-owned subsidiaries and

have been prepared in accordance with accounting principles generally accepted in the United States of America (U.S.). All intercompany accounts and
transactions have been eliminated in consolidation.

2. Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America (GAAP)

requires management to make estimates that affect the reported amounts of assets and liabilities at the date of the financial statements, disclosure of
contingent assets and liabilities, and the reported amounts of revenue and expenses during the reporting period. Management continually re-evaluates its
estimates, judgments and assumptions, and management’s evaluation could change. Actual results could differ from those estimates.

Cash, Cash Equivalents and Restricted Cash

For purposes of the Consolidated Balance Sheets and Consolidated Statements of Cash Flows, cash equivalents represent highly-liquid investments
with a maturity date of three months or less at the date of purchase. Cash and cash equivalents include investments in money market funds with commercial
banks and financial institutions, and commercial paper of high-quality corporate issuers. Restricted cash relates primarily to amounts held as collateral for
letters of credit for leases for office space at the Company’s Washington, D.C. headquarters.

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The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the Consolidated Balance Sheets to the total

end of period cash, cash equivalents and restricted cash reported within the Consolidated Statement of Cash Flows:

(in thousands)
Cash and cash equivalents

Restricted cash included in:

Prepaid expenses and other current assets

Non-current inventory and other

Total cash, cash equivalents and restricted cash

Marketable Securities

December 31,

2019

2018

45,072 $

61,005

—

578

45,650 $

157

587

61,749

The Company classifies all of its marketable securities as available-for-sale securities. The Company’s investment policy requires the selection of
high-quality issuers. Available-for-sale securities are carried at fair market value, with unrealized gains and losses reported as a component of stockholders’
equity in accumulated other comprehensive income (loss). At each balance sheet date, the Company assesses available-for-sale securities in an unrealized loss
position to determine whether the unrealized loss is other-than-temporary. If declines in the value of available for-sale securities are determined to be other-
than-temporary, a loss is recorded in earnings in the current period. Interest and dividend income is recorded when earned and included in other income.
Premiums and discounts on marketable securities are amortized and accreted, respectively, to earliest call date and maturity, respectively, and included in
other income. The Company uses the specific identification method in computing realized gains and losses on the sale of investments, which would be
included in the consolidated statements of operations when generated. All available-for-sale marketable securities are available for use in current operations
and are classified as current.

Inventory

Inventory, which is recorded at the lower of cost or net realizable value, includes the cost of third-party manufacturing and other direct and indirect
costs and is valued using the first-in, first-out method. The Company capitalizes inventory costs associated with its products upon regulatory approval when,
based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized; otherwise,
such costs are expensed as research and development. Inventory not expected to be sold within 12 months following the balance sheet date are classified as
non-current.

Intangible Assets

Costs incurred for products not yet approved by the FDA and for which no alternative future use exists are recorded as expense. Obligations for

milestone payments to other pharmaceutical companies that may result in a capitalized intangible asset are recognized when it is deemed probable that the
milestone event will occur. In the event a product has been approved by the FDA or an alternative future use exists for a product, patent and license costs are
capitalized and amortized on a straight-line basis over the estimated useful economic life of the of the related product patents. For intangible assets related to
HETLIOZ®, the estimated useful life is the estimated economic useful life of the related product patents, the latest of which expires in July 2035. Intangible
assets related Fanapt® have been fully amortized on a straight-line basis to November 2016. The useful life estimate for Fanapt® was based on the market
participant methodology prescribed by ASC 805, and therefore does not reflect the impact of additional Fanapt® patents solely owned by the Company with
varying expiration dates, the latest of which is December 2031.

Property and Equipment

Property and equipment are stated at cost less accumulated depreciation. Depreciation of most property and equipment is provided on a straight-line

basis over the estimated useful lives of the assets. Leasehold improvements are amortized using a straight-line basis over the lesser of the estimated useful
lives of the assets or the terms of the related leases. The costs of additions and improvements are capitalized, and repairs and maintenance costs are charged to
operations in the period incurred. Upon retirement or disposition of property and equipment, the cost and accumulated depreciation are removed from the
accounts and any resulting gain or loss is reflected in the statement of operations for that period.

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Leases

In accordance with Accounting Standards Codification (ASC) 842, Leases, effective January 1, 2019, the Company determines if an arrangement

contains a lease at inception. Right-of-use (ROU) assets represent the Company's right to use an underlying asset for the lease term and lease liabilities
represent the Company's obligation to make lease payments arising from that lease. For leases with a term greater than 12 months, ROU assets and liabilities
are recognized at the lease commencement date based on the estimated present value of lease payments over the lease term. The lease term includes the
option to extend the lease when it is reasonably certain the Company will exercise that option. When available, the Company uses the rate implicit in the lease
to discount lease payments to present value. In the case the implicit rate is not available, the Company uses its incremental borrowing rate based on
information available at the lease commencement date, including publicly available data for instruments with similar characteristics, to determine the present
value of lease payments. The Company does not combine lease and non-lease elements for office leases. For existing leases as of January 1, 2019, executory
costs are excluded from lease expense, which is consistent with the Company's accounting under ASC 840, Leases. For all leases entered into after January 1,
2019, executory costs are allocated between lease and non-lease elements based upon their relative stand-alone prices.

Accounts Payable and Accrued Liabilities

The Company’s management is required to estimate accrued liabilities as part of the process of preparing financial statements. The estimation of

accrued liabilities involves identifying services that have been performed on the Company’s behalf, and then estimating the level of service performed and the
associated cost incurred for such services as of each balance sheet date in the financial statements. Accrued liabilities include research and development
expenses, such as accrued costs under contracts with clinical monitors, data management organizations and investigators in conjunction with clinical trials,
fees to contract manufacturers in conjunction with the production of clinical materials, consulting and professional fees, such as lawyers and fees for
marketing and other commercialization activities, accrued compensation and employee benefits, such as accrued bonus, royalties payable under licensing
agreements, and other accrued fees. Pursuant to management’s assessment of the services that have been performed on clinical trials and other contracts, the
Company recognizes these expenses as the services are provided. Such management assessments include, but are not limited to: (i) an evaluation by the
project manager of the work that has been completed during the period, (ii) measurement of progress prepared internally and/or provided by the third-party
service provider, (iii) analyses of data that justify the progress, and (iv) management’s judgment. In the event that the Company does not identify certain costs
that have begun to be incurred or the Company under- or over-estimates the level of services performed or the costs of such services, the Company’s reported
expenses for such period would be too low or too high.

Revenue Recognition

In accordance with ASC Subtopic 606 Revenue from Contracts with Customers (ASC 606), which the Company adopted January 1, 2018, the
Company accounts for a contract when it has approval and commitment from both parties, the rights of the parties are identified, payment terms are identified,
the contract has commercial substance and collectability of consideration is probable. The Company recognizes revenue when control of the product is
transferred to the customer in an amount that reflects the consideration the Company expects to be entitled to in exchange for those product sales, which is
typically once the product physically arrives at the customer. Sales taxes, value add taxes, and usage-based taxes are excluded from revenues. Results for
reporting period ended December 31, 2017 were not adjusted and continue to be reported in accordance with historic accounting under ASC 605. The impact
to the Consolidated Statements of Operations if the Company had applied ASC 606 for the year ended December 31, 2017 is not material.

The Company’s net product sales consist of sales of HETLIOZ® and Fanapt®. Net sales by product for the years ended December 31, 2019, 2018 and

2017 were as follows:

(in thousands)
HETLIOZ® product sales, net
Fanapt® product sales, net
Total net product sales

Year Ended December 31,

2019

2018

2017

142,980 $

115,835 $

84,208

77,283

227,188

193,118

89,978

75,105

165,083

HETLIOZ® is available in the U.S. for distribution through a limited number of specialty pharmacies, and is not available in retail pharmacies.

Specialty pharmacy customers include Diplomat Pharmacy, Inc. (a subsidiary of UnitedHealth Group) and Accredo (a subsidiary of Express Scripts). Fanapt®
is available in the U.S. for distribution through a limited number of wholesalers and is available in retail pharmacies. Wholesaler customers include Cardinal
Health, Inc., AmerisourceBergen

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Drug Corporation, and McKesson Corporation. The Company invoices and records revenue when its customers, specialty pharmacies and wholesalers,
receive product from the third-party logistics warehouse which is the point at which control is transferred to the customer. Revenues and accounts receivable
are concentrated with these customers. The Company evaluates outstanding receivables to assess collectability. In performing this evaluation, the Company
analyzes economic conditions, the aging of receivables and customer specific risks.

The following table presents each major customer that represented more than 10% of total revenues for the years ended December 31, 2019, 2018

and 2017:

Percent of Net Product Sales
Distributor A

Distributor B

Distributor C

Distributor D

Distributor E

Distributor F

Year Ended December 31,

2019

2018

2017

38%

23%

12%

11%

—%

37%

17%

14%

12%

32%

10%

15%

12%

11%

The following table presents each major customer that represented more than 10% of accounts receivable, net, as of December 31, 2019 and 2018:

Percent of Accounts Receivable, Net
Distributor A

Distributor B

Distributor C

Distributor D

Distributor E

December 31,

2019

2018

21%

18%

16%

18%

30%

15%

20%

13%

16%

The transaction price is determined based upon the consideration to which the Company will be entitled in exchange for transferring product to the
customer. The Company’s product sales are recorded net of applicable product revenue allowances for which reserves are established and include discounts,
rebates, chargebacks, service fees, co-pay assistance and product returns that are applicable for various government and commercial payors. The Company
estimates the amount of variable consideration that should be included in the transaction price utilizing the most likely amount method and updates its
estimate at each reporting date. Variable consideration is included in the transaction price if, in the Company’s judgment, it is probable that a significant future
reversal of cumulative revenue under the contract will not occur. Allowances for rebates, chargebacks and co-pay assistance are based upon the insurance
benefits of the end customer, which are estimated using historical activity and, where available, actual and pending prescriptions for which the Company has
validated the insurance benefits. Reserves for variable consideration are classified as product revenue allowances on the consolidated balance sheets, with the
exception of prompt-pay discounts which are classified as reductions of accounts receivable. The reserve for product returns for which the product may not be
returned for a period of greater than one year from the balance sheet date is included as a component of other non-current liabilities in the consolidated
balance sheets. Uncertainties related to variable consideration are generally resolved in the quarter subsequent to period end, with the exception of Medicaid
rebates, which are dependent upon the timing of when states submit reimbursement claims, and product returns which are resolved during the product expiry
period specified in the customer contract. The Company currently records sales allowances for the following:

Prompt-pay: Specialty pharmacies and wholesalers are offered discounts for prompt payment. The Company expects that the specialty pharmacies
and wholesalers will earn prompt payment discounts and, therefore, deducts the full amount of these discounts from total product sales when
revenues are recognized.

Rebates: Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program as well as contracted rebate programs with
other payors. Rebate amounts owed after the final dispensing of the product to a benefit plan participant are based upon contractual agreements or
legal requirements with public sector benefit providers, such as Medicaid. The allowance for rebates is based on statutory or contracted discount
rates and estimated patient utilization.

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Chargebacks: Chargebacks are discounts that occur when contracted indirect customers purchase directly from specialty pharmacies and
wholesalers. Contracted indirect customers, which currently consist primarily of Public Health Service institutions, non-profit clinics, and federal
government entities purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The specialty pharmacy or
wholesaler, in turn, charges back the difference between the price initially paid by the specialty pharmacy or wholesaler and the discounted price
paid to the specialty pharmacy or wholesaler by the contracted customer.

Medicare Part D Coverage Gap: Medicare Part D prescription drug benefit mandates manufacturers to fund approximately 50% of the Medicare
Part D insurance coverage gap for prescription drugs sold to eligible patients through 2018. Public Law No. 115-123, also known as the Bipartisan
Budget Act of 2018 enacted on February 9, 2018 increased the manufacturer discount from 50% to 70% effective in 2019 for applicable drugs.
Vanda accounts for the Medicare Part D coverage gap using a point of sale model. Estimates for expected Medicare Part D coverage gap are based in
part on historical activity and, where available, actual and pending prescriptions for which the Company has validated the insurance benefits.

Service Fees: The Company receives sales order management, data and distribution services from certain customers. These fees are based on
contracted terms and are known amounts. The Company accrues service fees at the time of revenue recognition, resulting in a reduction of product
sales and the recognition of an accrued liability, unless it is a payment for a distinct good or service from the customer in which case the fair value of
those distinct goods or services are recorded as selling, general and administrative expense.

Co-payment Assistance: Patients who have commercial insurance and meet certain eligibility requirements may receive co-payment assistance. Co-
pay assistance utilization is based on information provided by the Company’s third-party administrator.

Product Returns: The Company generally offers direct customers a limited right to return as contractually defined with the customers. The Company
considers several factors in the estimation process, including expiration dates of product shipped to customers, inventory levels within the
distribution channel, product shelf life, historical return activity, including activity for product sold for which the return period has past, prescription
trends and other relevant factors. The Company does not expect returned goods to be resalable. There was no right of return asset as of December 31,
2019 or 2018. The following table summarizes activity for product returns as of and for the years ended December 31, 2019, 2018 and 2017, all of
which relates to sales of Fanapt®:

(in thousands)
Balances at December 31, 2016

Additions

Credits/payments

Balances at December 31, 2017

Additions

Credits/payments

Balances at December 31, 2018

Additions

Credits/payments

Balances at December 31, 2019

Cost of Goods Sold

Reserve for Product
Returns

3,080

5,978

(4,939)

4,119

2,684

(1,616)

5,187

3,138

(2,205)

6,120

Cost of goods sold includes royalties payable, the cost of inventory sold, manufacturing and supply chain costs and product shipping and handling

costs related to sales of HETLIOZ® and Fanapt® to the Company’s distribution partners.

Research and Development Expenses

Research and development expenses consist primarily of fees for services provided by third parties in connection with the clinical trials, costs of

contract manufacturing services, milestone payments, costs of materials used in clinical trials and research and development, costs for regulatory consultants
and filings, depreciation of capital resources used to develop products, related facilities costs, and salaries, other employee-related costs and stock-based
compensation for research and development personnel. The Company expenses research and development costs as they are incurred for products in the

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development stage, including manufacturing costs and milestone payments made under license agreements prior to FDA approval. Upon and subsequent to
FDA approval, manufacturing and milestone payments related to license agreements are capitalized. Milestone payments are accrued when it is deemed
probable that the milestone event will be achieved. Costs related to the acquisition of intellectual property are expensed as incurred if the underlying
technology is developed in connection with the Company’s research and development efforts and has no alternative future use.

Selling, General and Administrative Expenses

Selling, general and administrative expenses consist of salaries, stock-based compensation, facilities and third party expenses. Selling, general and
administrative expenses are associated with the activities of the corporate, finance, accounting, information technology, business development, commercial
support, trade and distribution, sales, marketing, legal, medical affairs and human resource functions. Additionally, selling, general and administrative
expenses included an estimate for the annual Affordable Care Act fee.

Stock-Based Compensation

Compensation costs for all stock-based awards to employees and directors are measured based on the grant date fair value of those awards and

recognized over the period during which the employee or director is required to perform service in exchange for the award. The Company recognizes the
expense over the award’s vesting period. The fair value of stock options granted and restricted stock units (RSUs) awarded are amortized using the straight-
line method. As stock-based compensation expense recognized in the consolidated statements of operations is based on awards ultimately expected to vest, it
has been reduced for estimated forfeitures. Forfeitures are estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures
differ from those estimates.

Advertising Expense

The Company expenses the costs of advertising, including branded promotional expenses, as incurred. Branded advertising expenses, recorded in

selling, general and administrative expenses, were $3.2 million, $0.9 million and $1.3 million for the years ended December 31, 2019, 2018 and 2017,
respectively.

Foreign Currency

The reporting currency of the Company is the U.S. dollar. The functional currency of the Company’s international subsidiaries is the local currency.

Assets and liabilities denominated in foreign currencies, including intercompany balances for which settlement is anticipated in the foreseeable future, are
translated at exchange rates in effect at the balance sheet date. Foreign currency equity balances are translated at historical rates. Revenues and expenses
denominated in foreign currencies are translated at average exchange rates for the respective periods. Foreign currency translation adjustments are recorded in
accumulated other comprehensive income (loss).

Transactions denominated in currencies other than subsidiaries’ functional currencies are recorded based on exchange rates at the time such
transactions arise. Changes in exchange rates with respect to amounts recorded in the consolidated balance sheets related to these items will result in
unrealized foreign currency transaction gains and losses based upon period-end exchange rates. The Company also records realized foreign currency
transaction gains and losses upon settlement of the transactions. Foreign currency transaction gains and losses are included in other income and were not
material for the years ended December 31, 2019, 2018 and 2017, respectively.

Income Taxes

The Company accounts for income taxes using the asset and liability method. Under the asset and liability method, current income tax expense or

benefit is the amount of income taxes expected to be payable or refundable for the current year. A deferred income tax asset or liability is recognized for
future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax
bases and tax credits and loss carryforwards. Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely
than not that some portion of the deferred tax assets will not be realized. Tax rate changes are reflected in income during the period such changes are enacted.
Changes in ownership may limit the amount of net operating loss (NOL) carryforwards that can be utilized in the future to offset taxable income. Tax benefits
are recognized from an uncertain tax position only if it is more likely than not that the position will be sustained on examination by the taxing authorities
based on the technical merits of the position. The tax benefit recognized in the financial statements for a particular tax position is based on the largest benefit
that is more likely than not to be realized upon settlement.

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Certain Risks and Uncertainties

The Company’s products under development require approval from the FDA or other international regulatory agencies prior to commercial sales.

There can be no assurance the products will receive the necessary clearance. If the Company is denied clearance or clearance is delayed, it may have a
material adverse impact on the Company.

The Company’s products are concentrated in rapidly-changing, highly-competitive markets, which are characterized by rapid technological

advances, changes in customer requirements and evolving regulatory requirements and industry standards. Any failure by the Company to anticipate or to
respond adequately to technological developments in its industry, changes in customer requirements or changes in regulatory requirements or industry
standards or any significant delays in the development or introduction of products or services could have a material adverse effect on the Company’s business,
operating results and future cash flows.

The Company depends on single source suppliers for critical raw materials for manufacturing, as well as other components required for the

administration of its products. The loss of these suppliers could delay the clinical trials or prevent or delay commercialization of the products.

Concentrations of Credit Risk

Financial instruments, which potentially subject the Company to significant concentrations of credit risk, consist primarily of cash, cash equivalents
and marketable securities. The Company places its cash, cash equivalents and marketable securities with highly-rated financial institutions. At December 31,
2019, the Company maintained all of its cash, cash equivalents and marketable securities in two financial institutions. Deposits held with these institutions
may exceed the amount of insurance provided on such deposits. Generally, these deposits may be redeemed upon demand, and the Company believes there is
minimal risk of losses on such balances.

Segment and Geographic Information

The Company operates in one reporting segment and, accordingly, no segment disclosures are presented herein. Foreign sales were not material for

each of the years ended December 31, 2019, 2018 and 2017.

Recent Accounting Pronouncements

In December 2019, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update (ASU) 2019-12, Income Taxes (Topic

740): Simplifying the Accounting for Income Taxes, which clarifies and simplifies certain aspects of the accounting for income taxes. The standard is effective
for years beginning after December 15, 2020, and interim periods within annual periods beginning after December 15, 2020. The Company is evaluating this
standard to determine if adoption will have a material impact on the Company’s consolidated financial statements.

In August 2018, the U.S. Securities and Exchange Commission (SEC) adopted the final rule under SEC Release No. 33-10532, Disclosure Update
and Simplification. This final rule amends certain disclosure requirements that are redundant, duplicative, overlapping, outdated or superseded. In addition,
the amendments expand the disclosure requirements on the analysis of stockholders' equity for interim financial statements. Under the amendments, an
analysis of changes in each caption of stockholders' equity presented in the balance sheet must be provided in a note or separate statement. The analysis
should present a reconciliation of the beginning balance to the ending balance of each period for which a statement of comprehensive income is required to be
filed. This final rule is effective for the Company for all filings made on or after November 5, 2018. The SEC staff clarified that the first presentation of the
changes in shareholders' equity may be included in the first Form 10-Q for the quarter that begins after the effective date of the amendments. The adoption of
the final rule did not have a material impact on the Company’s consolidated financial statements.

In June 2016, the FASB issued ASU 2016-13, Financial Instruments – Credit Losses, which changes the impairment model for most financial assets

and certain other financial instruments. The standard will require the use of a forward-looking “expected loss” model for instruments measured at amortized
cost that generally will result in the earlier recognition of allowances for losses. The standard is effective for years beginning after December 15, 2019, and
interim periods within annual periods beginning after December 15, 2019. The adoption of this standard is not expected to have a material impact on the
Company's consolidated financial results.

In February 2016, the FASB issued ASU 2016-2, Leases (Topic 842), which was further clarified by ASU 2018-10, Codification Improvements to

Topic 842, Leases, and ASU 2018-11, Leases - Targeted Improvements, issued in July

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2018. ASC 842 supersedes existing lease guidance, including ASC 840 Leases. The new leasing standard is effective for fiscal years beginning after
December 15, 2018, including interim periods within those fiscal years. The new leasing standard requires that lessees will need to recognize an ROU asset
and a lease liability for virtually all of their leases, and allows companies to make a policy election as to whether short term leases will be recognized under
the requirements of the new standard. The Company elected to exclude short-term leases in the application of the new standard. The lease liability is equal to
the present value of lease payments. The ROU asset is based on the liability subject to certain adjustments. For income statement purposes, the FASB retained
a dual model, requiring leases to be classified as either operating or finance. Operating leases will result in straight-line expense, similar to accounting for
operating leases under ASC 840, while finance leases will result in a front-loaded expense pattern, similar to accounting for capital leases under ASC 840.

The Company adopted the new leasing standard in the first quarter of 2019, using a modified retrospective transition. There was no impact to the

opening balance of retained earnings as of the effective date of January 1, 2019 as a result of adoption. Prior period financial statements were not recast. The
Company elected the package of transition provisions available for expired or existing contracts, which allowed it to carryforward its historical assessments of
(1) whether contracts are or contain leases, (2) lease classification and (3) initial direct costs. The adoption of the new leasing standard on January 1, 2019
resulted in the recognition of $15.8 million of operating lease liabilities, $2.2 million of which were classified as current liabilities, with corresponding ROU
assets of $12.2 million, net of lease prepayments and the balance of deferred lease incentives. The Company does not have any financing leases.

3. Marketable Securities

The following is a summary of the Company’s available-for-sale marketable securities as of December 31, 2019, which all have contractual

maturities of less than two years:

(in thousands)
U.S. Treasury and government agencies

Corporate debt

Asset-backed securities

Total marketable securities

Amortized
Cost

Gross
Unrealized
Gains

Gross
Unrealized
Losses

Fair
Market
Value

88,535 $

129,860

48,355

266,750

68 $

196

313

(2) $

(1)

(3)

(6)

88,601

130,055

48,401

267,057

The following is a summary of the Company’s available-for-sale marketable securities as of December 31, 2018, which all have contract maturities

of less than one year:

(in thousands)
U.S. Treasury and government agencies

Corporate debt

Asset-backed securities

Total marketable securities, current

4. Fair Value Measurements

Amortized
Cost

Gross
Unrealized
Gains

Gross
Unrealized
Losses

Fair
Market
Value

69,275 $

105,897

21,189

196,361

12 $

—

(17) $

(25)

(14)

(56)

69,270

105,910

21,175

196,355

Authoritative guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value. These tiers include:

•

Level 1 — defined as observable inputs such as quoted prices in active markets

Level 2 — defined as inputs other than quoted prices in active markets that are either directly or indirectly observable

Level 3 — defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions

Marketable securities classified in Level 1 and Level 2 as of December 31, 2019 and 2018 consist of cash equivalents and available-for-sale
marketable securities. The valuation of Level 1 instruments is determined using a market approach, and is based upon unadjusted quoted prices for identical
assets in active markets. The valuation of investments classified in Level 2

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also is determined using a market approach based upon quoted prices for similar assets in active markets, or other inputs that are observable for substantially
the full term of the financial instrument. Level 2 securities include certificates of deposit, commercial paper, corporate notes, and asset-backed securities that
use as their basis readily observable market parameters.

The Company held certain assets that are required to be measured at fair value on a recurring basis as of December 31, 2019, as follows:

(in thousands)
U.S. Treasury and government agencies

Corporate debt

Asset-backed securities

Total assets measured at fair value

Total Fair Value

88,601 $

137,025

48,401

274,027

Fair Value Measurement as of December 31, 2019 Using

Quoted Prices in
Active Markets for
Identical Assets
(Level 1)

Significant Other
Observable Inputs
(Level 2)

Significant
Unobservable
Inputs
(Level 3)

88,601 $

—

— $

137,025

48,401

88,601

185,426

The Company held certain assets that are required to be measured at fair value on a recurring basis as of December 31, 2018, as follows:

(in thousands)
U.S. Treasury and government agencies

Corporate debt

Asset-backed securities

Total assets measured at fair value

Total Fair Value

69,270 $

105,910

21,175

196,355

Fair Value Measurement as of December 31, 2018 Using

Quoted Prices in
Active Markets for
Identical Assets
(Level 1)

Significant Other
Observable Inputs
(Level 2)

Significant
Unobservable
Inputs
(Level 3)

69,270 $

—

— $

105,910

21,175

69,270

127,085

—

Total assets measured at fair value as of December 31, 2019 include $7.0 million of cash equivalents.

The Company also has financial assets and liabilities, not required to be measured at fair value on a recurring basis, which primarily consist of cash,

accounts receivable, restricted cash, accounts payable and accrued liabilities, product revenue allowances, and milestone obligations under license
agreements, the carrying values of which materially approximate their fair values.

5. Inventory

The Company evaluates expiry risk by evaluating current and future product demand relative to product shelf life. The Company builds demand

forecasts by considering factors such as, but not limited to, overall market potential, market share, market acceptance and patient usage. Inventory levels are
evaluated for the amount of inventory that would be sold within one year. At certain times, the level of inventory can exceed the forecasted level of cost of
goods sold for the next twelve months. The Company classifies the estimate of such inventory as non-current. Inventory consisted of the following as of
December 31, 2019 and 2018:

(in thousands)
Current assets

Work-in-process

Finished goods

Total inventory, current

Non-Current assets

Raw materials

Work-in-process

Finished goods

Total inventory, non-current

December 31,
2019

December 31,
2018

— $

1,140

1,140 $

659 $

1,109

1,056

2,824 $

946

994

2,290

516

2,892

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6. Property and Equipment

The following is a summary of the Company’s property and equipment, at cost, as of December 31, 2019 and 2018:

(in thousands)
Computer and other equipment

Furniture and fixtures

Leasehold improvements

Total property and equipment, gross

Accumulated depreciation and amortization

Total property and equipment, net

Estimated
Useful Life
(Years)
3

5 - 7

5 - 11

December 31, 2019

December 31, 2018
3,642

4,398 $

1,491

4,587

10,476

(6,612)

3,864 $

1,488

4,506

9,636

(5,219)

4,417

Depreciation expense was $1.4 million, $1.4 million and $1.2 million for the years ended December 31, 2019, 2018 and 2017, respectively.

7. Leases

The Company's long-term leases primarily include operating leases and subleases for office space in Washington, D.C. and London, England. The
Company recognized ROU assets and lease liabilities related to fixed payments for these long-term operating leases in its Consolidated Balance Sheet as of
December 31, 2019. The Company also has short-term leases, including office space in Berlin, Germany.

In June 2011, the Company entered into an operating lease agreement under which it leases 33,534 square feet of office space for its headquarters at
2200 Pennsylvania Avenue, N.W. in Washington, D.C. Subject to the prior rights of other tenants, the Company has the right to renew the lease for five years
following its expiration in July 2028. As of December 31, 2019, the renewal period has not been included in the lease term. The Company has the right to
sublease or assign all or a portion of the premises, subject to standard conditions. The lease may be terminated early by the Company or the landlord under
certain circumstances.

In June 2016, the Company entered into a sublease agreement under which it subleases an additional 9,928 square feet of office space for its

headquarters at 2200 Pennsylvania Avenue, N.W. in Washington, D.C. The sublease term began in January 2017 and ends in July 2026, but may be
terminated earlier by either party under certain circumstances. The Company has the right to sublease or assign all or a portion of the premises, subject to
standard conditions.

In May 2016, the Company entered into an operating lease agreement under which it leases 2,880 square feet of office space in London, England.

The Company has the right to renew the lease for five years following its expiration in 2021. As of December 31, 2019, the renewal period has not been
included in the lease term.

The following is a summary of the Company’s ROU assets and operating lease liabilities as of December 31, 2019:

(in thousands)
Assets

Operating lease assets

Liabilities

Operating lease current liabilities

Operating lease non-current liabilities

Total lease liabilities

Weighted average remaining lease term
Weighted average discount rate(1)

Classification on the Balance Sheet

December 31, 2019

Operating lease right-of-use assets

Accounts payable and accrued liabilities

Operating lease non-current liabilities

11,180

2,147

12,455

14,602

8.1

8.1%

(1) Upon adoption of the new lease standard, discount rates used for existing leases were established at January 1, 2019.

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For the year ended December 31, 2019, the Company recognized operating lease cost of $2.3 million and short-term operating lease cost of $0.4

million. The Company also recognized $1.4 million of expense related to non-lease elements, such as building maintenance services and utilities, and
executory costs associated with the operating leases. For existing leases as of January 1, 2019, executory costs are excluded from operating lease expense,
which is consistent with the Company's accounting under ASC 840. For all leases entered into after January 1, 2019, executory costs are allocated between
lease and non-lease elements based upon their relative stand-alone prices. For the years ended December 31, 2018 and 2017, the Company recognized $3.6
million and $3.2 million of rent expense, respectively, inclusive of lease expense, non-lease elements, and executory costs for short and long-term operating
leases.

Cash paid for amounts included in the measurement of operating lease liabilities is included in operating cash flows and was $2.5 million for the year

ended December 31, 2019.

The table below reconciles the Company's future cash obligations to operating lease liabilities recorded on the balance sheet as of December 31,

2019:

(in thousands)
2020

2021

2022

2023

2024

Thereafter

Total minimum lease payments

Less: amount of lease payments representing interest

Present value of future minimum lease payments

Less: current obligations under leases

Operating lease non-current liabilities

Operating Leases

2,326

2,332

2,355

2,420

2,488

8,182

20,103

(5,501)

14,602

(2,147)

12,455

At December 31, 2018, future minimum payments under noncancellable operating leases under ASC 840 were as follows:

Total

2019

2020

Cash Payments Due by Year
2021

2022

2023

Thereafter

22,757 $

2,483 $

2,495 $

2,335 $

2,355 $

2,420 $

10,669

(in thousands)
Operating leases

8. Intangible Assets

HETLIOZ®. In January 2014, the Company announced that the FDA had approved the New Drug Application (NDA) for HETLIOZ®. As a result of

this approval, the Company met a milestone under its license agreement with Bristol-Myers Squibb (BMS) that required the Company to make a license
payment of $8.0 million to BMS. The $8.0 million is being amortized on a straight-line basis over the estimated economic useful life of the related product
patents, the latest of which expires in July 2035.

In April 2018, the Company met its final milestone under its license agreement when cumulative worldwide sales of HETLIOZ® reached $250.0
million. As a result of the achievement of this milestone, the Company made a payment to BMS of $25.0 million in 2018. The $25.0 million, which was
capitalized as an intangible asset in the first quarter of 2015, was determined to be additional consideration for the acquisition of the HETLIOZ® intangible
asset and is being amortized on a straight-line basis over the estimated economic useful life of the related product patents, the latest of which expires in July
2035.

The estimated economic useful life of both the $8.0 million and the $25.0 million intangible assets were changed from February 2035 to July 2035
based on the July 2035 expiration date of U.S. patent number 10,376,487 ('487 Patent) issued by the U.S. Patent and Trademark Office in August 2019. The
estimated economic useful life of these intangible assets were

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previously changed from May 2034 to February 2035 based on the February 2035 expiration date of U.S. patent number 10,071,977 ('977 Patent) issued by
the U.S. Patent and Trademark Office in September 2018.

The following is a summary of the Company’s intangible assets as of December 31, 2019:

(in thousands)
HETLIOZ®

Estimated
Useful Life
(Years)
July 2035

Gross
Carrying
Amount

December 31, 2019

Accumulated
Amortization

Net
Carrying
Amount

33,000 $

9,963 $

23,037

The following is a summary of the Company’s intangible assets as of December 31, 2018:

(in thousands)
HETLIOZ®

Estimated
Useful Life
(Years)
February 2035

Gross
Carrying
Amount

December 31, 2018

Accumulated
Amortization

Net
Carrying
Amount

33,000 $

8,458 $

24,542

As of December 31, 2019 and 2018, the Company also had $27.9 million of fully amortized intangible assets related to Fanapt®.

Intangible assets are amortized over their estimated useful economic life using the straight-line method. Amortization expense for the years ended

December 31, 2019, 2018 and 2017 was as follows:

(in thousands)
HETLIOZ®

Year Ended December 31,

2019

2018

2017

1,505 $

1,527 $

1,750

The following is a summary of the future intangible asset amortization schedule as of December 31, 2019:

(in thousands)
HETLIOZ®

Total

2020

2021

2022

2023

2024

Thereafter

23,037 $

1,478 $

15,647

9. Accounts Payable and Accrued Liabilities

The following is a summary of the Company’s accounts payable and accrued liabilities as of December 31, 2019 and 2018:

(in thousands)
Compensation and employee benefits

Royalties payable

Research and development expenses

Consulting and other professional fees

Operating lease liabilities

Other

Total accounts payable and accrued liabilities

10. Commitments and Contingencies

Guarantees and Indemnifications

December 31,
2019

December 31,
2018

6,597 $

5,904

5,893

5,376

2,147

1,673

27,590 $

6,363

5,172

5,593

2,924

—

1,532

21,584

The Company has entered into a number of standard intellectual property indemnification agreements in the ordinary course of its business. Pursuant

to these agreements, the Company indemnifies, holds harmless, and agrees to reimburse the indemnified party for losses suffered or incurred by the
indemnified party, generally the Company’s business partners or customers, in connection with any U.S. patent or any copyright or other intellectual property
infringement claim by any third party with respect to the Company’s products. The term of these indemnification agreements is generally perpetual from the
date of execution of the agreement. The maximum potential amount of future payments the Company could be required to make under these indemnification
agreements is unlimited. Since inception, the Company has not incurred costs to defend

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lawsuits or settle claims related to these indemnification agreements. The Company also indemnifies its officers and directors for certain events or
occurrences, subject to certain conditions.

License Agreements

The Company’s rights to develop and commercialize its products are subject to the terms and conditions of licenses granted to the Company by other

pharmaceutical companies.

HETLIOZ®. In February 2004, the Company entered into a license agreement with BMS under which it received an exclusive worldwide license

under certain patents and patent applications, and other licenses to intellectual property, to develop and commercialize HETLIOZ®. To date, the Company has
paid BMS $37.5 million in upfront fees and milestone obligations, including $33.0 million of regulatory approval and commercial milestones capitalized as
intangible assets (see Note 8). The Company has no remaining milestone obligations to BMS. Additionally, the Company is obligated to make royalty
payments on HETLIOZ® net sales to BMS in any territory where the Company commercializes HETLIOZ® for a period equal to the greater of 10 years
following the first commercial sale in the territory or the expiry of the new chemical entity (NCE) patent in that territory. During the period prior to the expiry
of the NCE patent in a territory, the Company is obligated to pay a 10% royalty on net sales in that territory. The royalty rate is decreased by half for countries
in which no NCE patent existed or for the remainder of the 10 years after the expiry of the NCE patent. The Company is also obligated under the license
agreement to pay BMS a percentage of any sublicense fees, upfront payments and milestone and other payments (excluding royalties) that it receives from a
third party in connection with any sublicensing arrangement, at a rate which is in the mid-twenties. The Company has agreed with BMS in the license
agreement for HETLIOZ® to use its commercially reasonable efforts to develop and commercialize HETLIOZ®.

Fanapt®. Pursuant to the terms of a settlement agreement with Novartis, Novartis transferred all U.S. and Canadian rights in the Fanapt® franchise to
the Company on December 31, 2014. The Company paid directly to Sanofi S.A. (Sanofi) a fixed royalty of 3% of net sales from November 16, 2016 through
December 31, 2019 related to manufacturing know-how. The Company is also obligated to pay Sanofi a fixed royalty on Fanapt® net sales equal to 6% on
Sanofi know-how not related to manufacturing under certain conditions for a period of up to 10 years in markets where the NCE patent has expired or was not
issued. The Company is obligated to pay this 6% royalty on net sales in the U.S. through November 2026.

Tradipitant. In April 2012, the Company entered into a license agreement with Eli Lilly and Company (Lilly) pursuant to which the Company

acquired an exclusive worldwide license under certain patents and patent applications, and other licenses to intellectual property, to develop and
commercialize an NK-1R antagonist, tradipitant, for all human indications. Lilly is eligible to receive future payments based upon achievement of specified
development, regulatory approval and commercialization milestones as well as tiered-royalties on net sales at percentage rates up to the low double digits. To
date, the Company has paid Lilly $3.0 million in upfront fees and development milestones, including a $2.0 million milestone payment in July 2018 as a
result of enrolling the first subject into a Phase III study for tradipitant. As of December 31, 2019, remaining milestone obligations include a $2.0 million
development milestone due upon the filing of the first marketing authorization for tradipitant either in the U.S. or European Union (E.U.), $10.0 million and
$5.0 million for the first approval of a marketing authorization for tradipitant in the U.S. and E.U., respectively, and up to $80 million for sales milestones.
The Company is obligated to use its commercially reasonable efforts to develop and commercialize tradipitant.

VQW-765. In connection with a settlement agreement with Novartis relating to Fanapt®, the Company received an exclusive worldwide license under

certain patents and patent applications, and other licenses to intellectual property, to develop and commercialize VQW-765, a Phase II alpha-7 nicotinic
acetylcholine receptor partial agonist. Pursuant to the license agreement, the Company is obligated to use its commercially reasonable efforts to develop and
commercialize VQW-765 and is responsible for all development costs. The Company has no milestone obligations; however, Novartis is eligible to receive
tiered-royalties on net sales at percentage rates up to the mid-teens.

Portfolio of CFTR activators and inhibitors. In March 2017, the Company entered into a license agreement with the University of California San
Francisco (UCSF), under which the Company acquired an exclusive worldwide license to develop and commercialize a portfolio of CFTR activators and
inhibitors. Pursuant to the license agreement, the Company will develop and commercialize the CFTR activators and inhibitors and is responsible for all
development costs under the license agreement, including current pre-investigational new drug development work. UCSF is eligible to receive future
payments based upon achievement of specified development and commercialization milestones as well as single-digit royalties on net sales. To date, the
Company has paid UCSF $1.2 million in upfront fees and development milestones, including an upfront license fee payment of $1.0 million in 2017 and a
$0.2 million development milestone payment in the March 2019. As of December 31, 2019, remaining milestone obligations include $12.2 million for
development milestones and $33.0 million for future

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regulatory approval and sales milestones. Included in the $12.2 million in development milestones is a $350,000 milestone due upon the conclusion of a
Phase I study for each licensed product but not to exceed $1.1 million in total for the CFTR portfolio.

Purchase Commitments

In the course of its business, the Company regularly enters into agreements with clinical organizations to provide services relating to clinical

development and clinical manufacturing activities under fee service arrangements. The Company’s current agreements for clinical and marketing services
may be terminated on generally 90 days’ notice without incurring additional charges, other than charges for work completed but not paid for through the
effective date of termination and other costs incurred by the Company’s contractors in closing out work in progress as of the effective date of termination.
Noncancellable long-term contractual cash obligations include noncancellable purchase commitments longer than one year and primarily relate to
commitments for media and data services, of which $9.2 million, $1.0 million and $0.5 million are expected to be paid in 2020, 2021 and 2022, respectively.

11. Public Offering of Common Stock

In March 2018, the Company completed a public offering of 6,325,000 shares of its common stock, including the exercise of the underwriters’

option to purchase an additional 825,000 shares of common stock, at a price to the public of $17.00 per share. Net cash proceeds from the public offering
were $100.9 million, after deducting the underwriting discounts and commissions and offering expenses.

12. Accumulated Other Comprehensive Income

The accumulated balances related to each component of other comprehensive income (loss), net of taxes, were as follows for the years ended

December 31, 2019 and 2018:

(in thousands)
Foreign currency translation

Unrealized gain (loss) on marketable securities

Accumulated other comprehensive income

December 31,
2019

December 31,
2018

13 $

236

249 $

(6)

There were no reclassifications out of accumulated other comprehensive income (loss) for the years ended December 31, 2019, 2018 and 2017.

13. Stock-Based Compensation

As of December 31, 2019, there were 6,144,430 shares that were subject to outstanding options and RSUs under the 2006 Equity Incentive Plan
(2006 Plan) and the Amended and Restated 2016 Equity Incentive Plan (2016 Plan, and together with the 2006 Plan, Plans). The 2006 Plan expired by its
terms on April 12, 2016, and the Company adopted the 2016 Plan. Outstanding options and RSUs under the 2006 Plan remain in effect and the terms of the
2006 Plan continue to apply, but no additional awards can be granted under the 2006 Plan. In June 2016, the Company’s stockholders approved the 2016 Plan.
The 2016 Plan has been amended and restated twice to increase the number of shares reserved for issuance, among other administrative changes. Both
amendments and restatements of the 2016 Plan were approved by the Company's stockholders. There are a total of 7,100,000 shares of common stock
reserved for issuance under the 2016 Plan, 3,026,147 shares of which remained available for future grant as of December 31, 2019.

Stock Options

The Company has granted option awards under the Plans with service conditions (service option awards) that are subject to terms and conditions

established by the compensation committee of the board of directors. Service option awards have 10-year contractual terms. Service option awards granted to
employees and new directors upon their election vest and become exercisable over four years, with the first 25% of the shares subject to service option
awards vesting on the first anniversary of the grant date and the remaining 75% of the shares subject to the service option awards in 36 equal monthly
installments thereafter. Subsequent annual service option awards granted to directors vest and become exercisable in full on the first anniversary of the grant
date. Certain service option awards to executives and directors provide for accelerated vesting if there is a change in control of the Company. Certain service
option awards to employees and executives provide for accelerated vesting if the respective employee’s or executive’s service is terminated by the Company
for any reason other than cause or permanent disability.

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As of December 31, 2019, $9.8 million of unrecognized compensation costs related to unvested service option awards are expected to be recognized

over a weighted average period of 1.4 years. No option awards are classified as a liability as of December 31, 2019.

The following is a summary of option activity for the 2006 Plan and the 2016 Plan for the years ended December 31, 2019, 2018, and 2017:

2006 and 2016 Plans
(in thousands, except for share and per share amounts)

Outstanding at December 31, 2016

Granted

Forfeited

Expired

Exercised

Outstanding at December 31, 2017

Granted

Forfeited

Exercised

Outstanding at December 31, 2018

Granted

Forfeited

Expired

Exercised

Outstanding at December 31, 2019

Exercisable at December 31, 2019

Vested and expected to vest at December 31, 2019

Number of
Shares

Weighted Average
Exercise Price at Grant
Date

Weighted Average
Remaining Term
(Years)

Aggregate
Intrinsic
Value

5,548,336 $

643,000

(290,729)

(605,617)

(575,206)

4,719,784

567,500

(232,527)

(685,715)

4,369,042

687,500

(53)

(15,000)

(546,344)

4,495,145

3,371,836

4,354,708

11.62

14.44

10.73

29.87

9.13

10.03

19.22

13.99

9.12

11.15

18.38

7.94

14.78

11.47

12.21

10.31

12.02

5.58 $

32,453

5.63

5.28

5.58

4.53

5.46

3,140

24,421

5,945

65,438

2,482

22,148

21,200

22,039

The weighted average grant-date fair value of options granted was $10.19, $10.66 and $7.81 per share for the years ended December 31, 2019, 2018
and 2017, respectively. Proceeds from the exercise of stock options amounted to $6.3 million, $6.3 million and $5.3 million for the years ended December 31,
2019, 2018 and 2017, respectively.

Restricted Stock Units

An RSU is a stock award that entitles the holder to receive shares of the Company’s common stock as the award vests. The fair value of each RSU is

based on the closing price of the Company’s stock on the date of grant. The Company has granted RSUs under the Plans with service conditions (service
RSUs) that vest in four equal annual installments provided that the employee remains employed with the Company. Annual service RSUs granted to directors
vest on the first anniversary of the grant date.

As of December 31, 2019, $22.8 million of unrecognized compensation costs related to unvested service RSUs are expected to be recognized over a

weighted average period of 1.8 years. No RSUs are classified as a liability as of December 31, 2019.

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The following is a summary of RSU activity for the 2006 Plan and the 2016 Plan for the years ended December 31, 2019, 2018, and 2017:

RSUs

Unvested at December 31, 2016

Granted

Forfeited

Vested

Unvested at December 31, 2017

Granted

Forfeited

Vested

Unvested at December 31, 2018

Granted

Forfeited

Vested

Unvested at December 31, 2019

Number of
Shares

1,138,428 $

Weighted
Average
Grant Date Fair Value
10.07

857,336

(275,613)

(362,313)

1,357,838

714,086

(229,603)

(528,745)

1,313,576

937,328

(75,444)

(526,175)

1,649,285

14.57

11.41

9.78

12.72

18.93

15.19

12.69

15.68

19.46

18.93

14.54

18.04

The grant date fair value for the 526,175 shares underlying RSUs that vested during the year ended December 31, 2019 was $7.7 million.

Stock-Based Compensation Expense

Stock-based compensation expense recognized for the years ended December 31, 2019, 2018 and 2017 was allocated as follows:

(in thousands)
Research and development

Selling, general and administrative

Total stock-based compensation expense

Year Ended December 31,

2019

2018

2017

3,207 $

10,251

13,458 $

1,290 $

10,376

11,666 $

1,152

9,313

10,465

The fair value of each option award is estimated on the date of grant using the Black-Scholes-Merton option pricing model that uses the assumptions
noted in the following table. Expected volatility rates are based on the historical volatility of the Company’s publicly traded common stock and other factors.
The risk-free interest rates are based on the U.S. Treasury yield for a period consistent with the expected term of the option in effect at the time of the grant.
The Company has never paid cash dividends to its stockholders and does not plan to pay dividends in the foreseeable future. Assumptions used in the Black-
Scholes-Merton option pricing model for employee and director stock options granted during the years ended December 31, 2019, 2018 and 2017 were as
follows:

Expected dividend yield

Weighted average expected volatility

Weighted average expected term (years)

Weighted average risk-free rate

14. Employee Benefit Plan

Year Ended December 31,

2019

2018

2017

—%

58%

5.95

2.26%

—%

58%

5.90

2.68%

—%

57%

5.89

1.97%

The Company has a defined contribution plan under IRC Section 401(k). This plan covers substantially all employees who meet minimum age and

service requirements and allows participants to defer a portion of their annual compensation on a pre-tax basis. Currently, the Company matches fifty percent
up to the first six percent of employee contributions. All matching

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contributions have been paid by the Company. The Company match vests over a 4-year period and amounted to $0.8 million, $0.9 million and $0.8 million
for the years ended December 31, 2019, 2018 and 2017, respectively.

15. Income Taxes

The following is a summary of the domestic and foreign components of income (loss) before income taxes for the years ended December 31, 2019,

2018 and 2017:

(in thousands)
Domestic

Foreign

Total income (loss) before income taxes

Year Ended December 31,

2019

2018

2017

28,794 $

25,123 $

234

223

29,028 $

25,346 $

(15,693)

262

(15,431)

The following is a summary of the provision (benefit) for income taxes for the years ended December 31, 2019, 2018 and 2017:

(in thousands)
Current:

Federal

State

Foreign

Deferred:

Federal

State

Foreign

Year Ended December 31,

2019

2018

2017

— $

1,161

(85,624)

(2,127)

(16)

— $

—

(14)

Provision (benefit) for income taxes

(86,525) $

138 $

—

(66)

—

137

136

The Company assesses the need for a valuation allowance against its deferred tax asset each quarter through the review of all available positive and

negative evidence. Deferred tax assets are reduced by a tax valuation allowance when, in the opinion of management, it is more likely than not that some
portion of the deferred tax assets will not be realized. The analysis depends on historical and projected taxable income. Projected taxable income includes
significant assumptions related to revenue, commercial expenses and research and development activities. During 2019, after considering all available
positive and negative evidence, including but not limited to cumulative income in recent periods, historical, current and future projected results and
significant risks and uncertainties related to forecasts, the Company concluded that it was more likely than not that substantially all of its deferred tax assets in
the U.S. are realizable in future periods. A valuation allowance has been retained against certain U.S. federal tax attributes with short carryforward periods
and District of Columbia state deferred tax assets as of December 31, 2019. A full valuation allowance was recorded against all net U.S. deferred tax assets as
of December 31, 2018.

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The income tax benefit for 2019 was primarily due to the reduction of the Company's valuation allowance against substantially all of its deferred tax

assets in the U.S. Tax expense associated with U.S. income before income taxes for the years ended December 31, 2019 and 2018 was offset by a
corresponding tax benefit for the reduction of the valuation allowance recorded against tax attributes that were utilized in those periods. Tax benefit associated
with U.S. loss before income taxes for the year ended December 31, 2017 was offset by a corresponding tax expense for the increase of the valuation
allowance recorded against tax attributes that were generated in that period. The following is reconciliation between the federal statutory tax rate and the
Company’s effective tax rate for the years ended December 31, 2019, 2018 and 2017:

Federal tax at statutory rate

State taxes

U.S. Tax Cuts and Job Act (1)

Change in valuation allowance - U.S. Tax Cuts and Jobs Act

Other change in valuation allowance (2)

Research and development credit (3)

Orphan drug credit (3)

Section 162(m) limitation

Other tax rate changes

Other changes in state deferred taxes (4)

Uncertain tax positions (5)

Stock-based compensation

Other items

Effective tax rate

Year Ended December 31,

2019

2018

2017

21.0 %

1.8 %

— %

(357.6)%

(10.9)%

17.1 %

2.7 %

(0.5)%

— %

26.3 %

(1.0)%

3.0 %

(298.1)%

21.0 %

1.7 %

— %

(16.4)%

(9.1)%

(2.7)%

3.1 %

(0.7)%

5.9 %

— %

(3.9)%

1.6 %

0.5 %

35.0 %

1.7 %

(262.6)%

262.6 %

(47.8)%

9.0 %

6.3 %

8.1 %

(2.6)%

5.1 %

— %

(13.0)%

(2.7)%

(0.9)%

(1)

(2)

(3)

(4)

(5)

Includes the effect of the Tax Cuts and Jobs Act, which primarily relates to the remeasurement of existing deferred taxes as a result of the change to
the U.S. federal tax rate.

Reductions in 2019 valuation allowances include $7.5 million related to 2019 U.S. income before income taxes, $10.7 related to adjustments for
prior period credit carryforwards and uncertain tax positions and $85.6 million related to a change in beginning-of-the-year balances that resulted
from a change in circumstances that caused a change in judgment about the realizability of U.S. deferred tax assets in future years. Reductions in
2018 valuation allowances are attributable to 2018 income before income taxes.

2019 activity includes adjustments to prior year credit carryforwards. As a result of the tax valuation allowance previously recorded against deferred
tax assets in the U.S., these adjustments resulted in no change in tax expense.

Includes adjustments to state deferred taxes based on changes to filing jurisdictions.

2019 activity includes adjustments to prior year tax positions. As a result of the tax valuation allowance previously recorded against deferred tax
assets in the U.S., these adjustments resulted in no change in tax expense.

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The following is a summary of the components of the Company’s deferred tax assets (liabilities) and the related tax valuation allowance as of

December 31, 2019 and 2018:

(in thousands)
Deferred tax assets:

Net operating loss carryforwards

Stock-based compensation

Accrued and deferred expenses

Allowance for returns and uncollectable receivables

Research and development and orphan drug credit carryforwards

Other

Total deferred tax assets

Deferred tax liabilities:

Intangible assets

Other

Total deferred tax liabilities

Deferred tax assets, net

Less: Valuation allowance

December 31,
2019

December 31,
2018

52,034 $

5,298

2,101

1,468

36,041

1,301

98,243

(1,994)

(414)

(2,408)

95,835

8,155

55,742

5,202

2,096

1,247

48,066

1,405

113,758

(1,247)

(576)

(1,823)

111,935

111,950

(15)

Net deferred tax assets (liabilities)

87,680 $

The Company’s net deferred tax liability of less than $0.1 million as of December 31, 2018 is included as a component of other non-current

liabilities.

The following is a summary of changes in the Company’s tax valuation allowance for the years ended December 31, 2019, 2018 and 2017:

(in thousands)

Year Ended:

December 31, 2019

December 31, 2018

December 31, 2017

Balance at
Beginning
of Year

Additions

Reductions

111,950 $

— $

(103,795) $

116,110

146,012

4,036

12,403

(8,196)

(42,305)

Balance at
End of
Year

8,155

111,950

116,110

The Company has NOL and other tax credit carryforwards in several jurisdictions. As of December 31, 2019, the Company has $43.3 million of

deferred tax assets relating to U.S. federal NOL carryforwards, along with deferred tax assets of $12.0 million and $24.0 million related to U.S. federal
research and development credits and orphan drug credits, respectively. These tax attributes will begin to expire in 2031, 2024 and 2030, respectively. In
addition, the Company has $8.7 million of deferred tax assets relating to U.S. state NOL carryforwards, which primarily relate to the District of Columbia.
State NOLs for the District of Columbia will begin to expire in 2031 and other state NOLs will begin to expire in 2021.

Tax benefits are recognized from an uncertain tax position only if it is more likely than not that the position will be sustained on examination by the
taxing authorities based on the technical merits of the position. The tax benefit recognized in the financial statements for a particular tax position is based on
the largest benefit that is more likely than not to be realized upon settlement.

A reconciliation of the beginning and ending amount of gross unrecognized tax benefits is as follows:

(in thousands)
Unrecognized tax benefits at the beginning of the year

Increases related to prior year tax positions

Increases related to current year tax positions

Unrecognized tax benefits at the end of the year

Year Ended December 31,

2019

2018

2017

— $

8,223

1,518

9,741 $

— $

—

— $

—

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The amount of uncertain tax benefits that, if recognized, would impact the effective tax rate is $9.7 million. No material income tax interest or

penalties have been recorded, and unrecognized tax benefits are not expected to change materially over the next 12 months. Income tax returns filed by the
Company for all periods are open to examination by tax jurisdictions. As of December 31, 2019, the Company is not under examination by any federal or
state tax jurisdiction.

Certain tax attributes of the Company, including NOLs and credits, would be subject to a limitation should an ownership change as defined under the

Internal Revenue Code of 1986, as amended (IRC), Section 382, occur. The limitations resulting from a change in ownership could affect the Company’s
ability to utilize its NOLs and credit carryforward (tax attributes). Ownership changes occurred in the years ending December 31, 2014 and December 31,
2008. The Company believes that the ownership changes in 2014 and 2008 will not impact its ability to utilize NOL and credit carryforwards; however, future
ownership changes may cause the Company’s existing tax attributes to have additional limitations.

The Tax Cuts and Jobs Act (TCJA) was enacted in December 2017. The TCJA reduces the U.S. federal corporate tax rate from 35% to 21%, requires

companies to pay a one-time transition tax on earnings of certain foreign subsidiaries that were previously deferred and creates new taxes on certain foreign
sourced earnings. During the fourth quarter of 2018, the Company completed its accounting for the tax effects of the TCJA. Effects of the TCJA resulted in
no tax expense in 2018 or 2017 as they were fully offset by a change in the Company's tax valuation allowance.

16. Earnings per Share

Basic earnings per share (EPS) is calculated by dividing the net income (loss) by the weighted average number of shares of common stock

outstanding. Diluted EPS is computed by dividing the net income (loss) by the weighted average number of shares of common stock outstanding, plus
potential outstanding common stock for the period. Potential outstanding common stock includes stock options and shares underlying RSUs, but only to the
extent that their inclusion is dilutive.

The following table presents the calculation of basic and diluted net income (loss) per share of common stock for the years ended December 31,

2019, 2018 and 2017:

(in thousands, except for share and per share amounts)
Numerator:

Net income (loss)

Denominator:

Weighted average shares outstanding, basic

Effect of dilutive securities

Weighted average shares outstanding, diluted

Net income (loss) per share, basic and diluted:

Basic

Diluted

Year Ended December 31,

2019

2018

2017

115,553 $

25,208 $

(15,567)

53,137,562

1,709,498

54,847,060

50,859,947

2,185,310

53,045,257

44,735,146

—

44,735,146

2.17 $

2.11 $

0.50 $

0.48 $

(0.35)

Antidilutive securities excluded from calculations of diluted net income (loss) per share

1,932,024

903,265

3,136,515

The Company incurred a net loss for the year ended December 31, 2017 causing inclusion of any potentially dilutive securities to have an anti-

dilutive effect, resulting in dilutive loss per share and basic loss per share attributable to common stockholders being equivalent.

17. Legal Matters

Fanapt®. The Company has been involved in litigation with Roxane Laboratories, Inc. (Roxane) and its affiliates, West-Ward Pharmaceuticals

International Limited and West-Ward Pharmaceuticals Corp (West-Ward), since the Company filed a lawsuit against Roxane in the U.S. District Court for the
District of Delaware (Delaware District Court) for patent infringement in June 2014. The lawsuit was filed in response to Roxane’s submission to the U.S.
Food and Drug Administration (FDA) of an Abbreviated New Drug Application (ANDA) for a generic version of Fanapt® prior to the expiration of certain of
the Company’s patents covering Fanapt®, including U.S. Patent No. 8,586,610 (‘610 Patent). In August 2016, the Delaware District Court ruled in the
Company’s favor, permanently enjoining Roxane from manufacturing, using,

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selling, offering to sell, distributing or importing any generic iloperidone product described in Roxane’s ANDA until the expiration of the ‘610 Patent in
November 2027, or May 2028 if the Company obtains pediatric exclusivity. In April 2018, following an appeal by Roxane of the Delaware District Court’s
decision to the Federal Circuit Court of Appeals (Federal Circuit), the Federal Circuit affirmed the Delaware District Court’s ruling. In June 2018, West-Ward,
having replaced Roxane as defendants following the acquisition of Roxane by West-Ward’s parent company, Hikma Pharmaceuticals PLC, petitioned the
Federal Circuit for a rehearing en banc. In August 2018, the Federal Circuit denied West-Ward's petition. In January 2019, West-Ward filed a petition in the
U.S. Supreme Court for a writ of certiorari seeking reversal of the Federal Circuit’s decision. In March 2019, the U.S. Supreme Court invited the Solicitor
General of the U.S. to file a brief in the matter expressing the views of the U.S. In January 2020, the U.S. Supreme Court denied West-Ward's petition for writ
of certiorari.

In 2015, the Company filed six separate patent infringement lawsuits in the Delaware District Court against Roxane, Inventia Healthcare Pvt. Ltd.

(Inventia), Lupin Ltd. and Lupin Pharmaceuticals, Inc. (Lupin), Taro Pharmaceuticals USA, Inc. and Taro Pharmaceutical Industries, Ltd. (Taro), and Apotex
Inc. and Apotex Corp. (Apotex, and collectively with Roxane, Inventia, Lupin and Taro, the Fanapt® Defendants). These lawsuits were filed in response to the
submission to the FDA by each of the Fanapt® Defendants of ANDAs for generic versions of Fanapt® prior to the expiration of the ‘610 Patent in November
2027 or the U.S. Patent No. 9,138,432 in September 2025. The Company entered into separate confidential stipulations with each of Inventia and Lupin
regarding any potential launch of their generic versions of Fanapt®. The parties are scheduled to provide the court with a status report in March 2020 with
respect to the remaining lawsuits against the other Fanapt® Defendants.

HETLIOZ®. In April and May 2018, the Company filed three separate patent infringement lawsuits in the Delaware District Court against Teva

Pharmaceuticals USA, Inc. (Teva), MSN Pharmaceuticals Inc. and MSN Laboratories Private Limited (MSN) and Apotex (collectively with Teva and MSN,
the HETLIOZ® Defendants) after having received Paragraph IV certification notice letters (Paragraph IV Letters) from each of the HETLIOZ® Defendants
alleging that certain of the Company's patents covering HETLIOZ® (collectively, the HETLIOZ® Patents) were invalid, unenforceable and/or would not be
infringed by the manufacture, use or sale of their generic versions of HETLIOZ®, as described in the ANDAs submitted to the FDA by each of the
HETLIOZ® Defendants, prior to the expiration of the latest to expire of the HETLIOZ® Patents in 2034. Each of the HETLIOZ® Patents are listed in the
Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book). In December 2018, the Company filed amended complaints against each
of the HETLIOZ® Defendants following the receipt of additional Paragraph IV Letters from Teva and Apotex concerning its Orange Book listed '977 Patent,
which expires in 2035. These lawsuits are scheduled for trial in October 2020.

In March 2019, April 2019, and May 2019, the Company filed three additional patent infringement lawsuits in the Delaware District Court against

the HETLIOZ® Defendants following the receipt of additional Paragraph IV Letters from each concerning its Orange Book listed U.S. Patent No. 10,149,829,
which expires in 2033. These lawsuits have been consolidated with the other lawsuits against the HETLIOZ® Defendants and are also scheduled for trial in
October 2020.

In November and December 2019, the Company filed additional patent infringement lawsuits in the Delaware District Court against Apotex and

Teva, respectively, for infringement of its Orange Book listed U.S. Patent No. 10,376,487 ('487 Patent) following the receipt of additional Paragraph IV
Letters from Apotex and Teva regarding the '487 Patent, which expires in July 2035. Teva asserted a counterclaim for a declaratory judgment that the ‘487
Patent is invalid. The Company answered Teva’s counterclaim by denying their allegation that the ‘487 Patent is invalid. In January 2020, the Company filed
two additional patent infringement lawsuits in the Delaware District Court against Teva and Apotex for infringement of its Orange Book-listed U.S. Patent
No. 10,449,176 (‘176 Patent) following the receipt of additional Paragraph IV Letters from Teva and Apotex regarding the ‘176 Patent, which expires in
January 2033. A trial date has not yet been scheduled for these lawsuits.

In January 2020, the Company received an additional Paragraph IV Letter from MSN concerning the '487 patent, in which MSN alleges that the ‘487

Patent is invalid, unenforceable and/or will not be infringed by the commercial manufacture, use, sale offer for sale, or importation of MSN's generic version
of HETLIOZ® as described in MSN's ANDA. The Company intends to vigorously pursue a patent infringement lawsuit permanently enjoining MSN from
infringing the claims of the ‘487 Patent.

Other Matters. In April 2018, the Company submitted a protocol amendment to the FDA, proposing a 52-week open-label extension (OLE) period
for patients who had completed the tradipitant Phase II clinical study (2301) in gastroparesis. In May 2018, based on feedback from the FDA, the Company
amended the protocol limiting the duration of treatment in the 2301 study to a total of three months, while continuing to seek further dialogue with the FDA
on extending the study duration to 52-weeks. As a part of this negotiation process, in September 2018, the Company submitted a new follow-on 52-week
OLE protocol to the FDA (2302) for patients who had completed the 2301 study. While waiting for further feedback, the Company did not enroll any patients
in any study beyond 12 weeks. In December 2018, the FDA imposed a partial clinical hold (PCH) on

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the two proposed studies, stating that the Company is required first to conduct additional chronic toxicity studies in canines, monkeys or minipigs before
allowing patients access in any clinical protocol beyond 12 weeks. At that time, the FDA informed the Company that the original PCH was not based on any
safety or efficacy data related to tradipitant, but, rather. that these additional toxicity studies were required by a guidance document. Subsequently, the FDA
has taken the position that an additional study was required in order for the FDA to have adequate toxicology data to undertake a risk analysis of tradipitant.

On February 5, 2019, the Company filed a lawsuit against the FDA in the U.S. District Court for the District of Columbia (DC District Court),

challenging the FDA’s legal authority to issue the PCH, and seeking an order to set it aside. In February 2019, the FDA filed a Motion for Voluntary Remand
to the Agency and for a Stay of the Case. In March 2019, the DC District Court granted the FDA’s request for voluntary remand and returned the matter to the
FDA for further consideration. In April 2019, the FDA provided its remand response, in which it indicated that, upon review of scientific literature and
tradipitant data, it believes that a PCH continues to be appropriate until the Company has adequate safety data from a nine-month non-rodent toxicity study. In
May 2019, the Company filed an amended complaint, and in July 2019, the Company filed a Motion for Summary Judgment based on its continuing belief
after review of the FDA’s remand response that additional chronic toxicity studies are unjustified, and that it has provided the FDA with sufficient information
regarding the safety of tradipitant to justify the continued study of tradipitant in patients beyond 12 weeks, in accordance with applicable law and FDA
regulations. The FDA filed a reply and cross-motion for summary judgment in October 2019 and an oral hearing was held on December 13, 2019. On January
31, 2020, the Court granted the FDA's cross-motion for summary judgment and granted judgment in favor of the FDA on the Company's claims. The
Company is evaluating its options, including a potential appeal, and the Company intends to continue vigorously pursuing its interests in the matter.

In February 2019, a qui tam action filed against the Company was unsealed by order of the DC District Court. The qui tam action, which was filed

under seal in March 2017, was brought by a former Company employee on behalf of the U.S., 28 states and the District of Columbia (collectively, the
Plaintiff States) and the policyholders of certain insurance companies under the Federal False Claims Act and state law equivalents to the Federal False
Claims Act and related state laws. The complaint alleged that the Company violated these laws through the promotion and marketing of its products Fanapt®
and HETLIOZ® and sought, among other things, treble damages, civil penalties for each alleged false claim, and attorneys’ fees and costs. By virtue of the
DC District Court having unsealed the original complaint, the Company learned that in January 2019, the U.S. Department of Justice (the DOJ), as well as the
Plaintiff States, elected not to intervene in the qui tam action at that time. In May 2019, the plaintiff filed an amended complaint under seal repeating the same
allegations and seeking the same relief. According to a filing unsealed in June 2019, the DOJ reaffirmed its decision not to intervene and incorporated its prior
filing, indicating that neither the DOJ nor the Plaintiff States were intervening regarding the original complaint. Although the DOJ and the Plaintiff States
have elected not to intervene, the plaintiff may litigate this action and the DOJ and the Plaintiff States may later seek to intervene in the action. In August
2019, the Company filed a motion to dismiss, and in October 2019 the plaintiff filed a reply. The Company intends to vigorously defend itself in the case. The
Court will hear the Company's motion to dismiss on March 20, 2020.

In February 2019, a securities class action, Gordon v. Vanda Pharmaceuticals Inc., was filed in the U.S. District Court for the Eastern District of
New York naming the Company and certain of its officers as defendants. An amended complaint was filed in July 2019. The amended complaint, filed on
behalf of a purported stockholder, asserts claims on behalf of a putative class of all persons who purchased the Company’s publicly traded securities between
November 4, 2015 and February 11, 2019, for alleged violations of Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule
10b-5 promulgated thereunder. The amended complaint alleges that the defendants made false and misleading statements and/or omissions regarding Fanapt®,
HETLIOZ® and the Company’s interactions with the FDA regarding tradipitant between November 3, 2015 and February 11, 2019. The Company believes
that it has meritorious defenses and intends to vigorously defend this lawsuit. The Company does not anticipate that this litigation will have a material adverse
effect on its business, results of operations or financial condition. However, this lawsuit is subject to inherent uncertainties, the actual cost may be significant,
and the Company may not prevail. The Company believes it is entitled to coverage under its relevant insurance policies, subject to a retention, but coverage
could be denied or prove to be insufficient.

In July 2019, a shareholder derivative complaint, Samuel Williams vs. Mihael Polymeropoulos, et al., was filed in the U.S. District Court for the

Eastern District of New York naming certain current and former Company directors and officers as defendants. In September 2019, a shareholder derivative
complaint, Michael Bavaro v. Mihael Polymeropoulos, et al., was filed in the Delaware District Court naming certain current and former Company directors
and officers as defendants. In October 2019, the Company filed a motion to transfer the Bavaro case to the Eastern District of New York, where the Gordon
and Williams cases are pending. In February 2020, the Delaware District Court issued an order staying the Bavaro case pending the resolution of the Williams
case. These complaints, filed on behalf of purported stockholders, derivatively on behalf of the Company, assert claims for alleged breach of fiduciary duties
by certain of the Company’s current and former directors and officers. The Company believes that it has meritorious defenses and intends to vigorously
defend these lawsuits. The Company

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does not anticipate that this litigation will have a material adverse effect on its business, results of operations or financial condition. However, these lawsuits
are subject to inherent uncertainties, the actual cost may be significant, and the Company may not prevail. The Company believes it is entitled to coverage
under its relevant insurance policies, subject to a retention, but coverage could be denied or prove to be insufficient.

In July 2017, the CHMP issued a negative opinion recommending against approval of Fanaptum® (oral iloperidone tablets) for the treatment of

schizophrenia in adult patients in the E.U. The CHMP was of the opinion that the benefits of Fanaptum® did not outweigh its risks and recommended against
marketing authorization. In March 2018, the Company filed an application seeking annulment of the EMA’s negative opinion and the subsequent European
Commission decision refusing marketing authorization of Fanaptum in the European General Court. In December 2019, the General Court issued its
judgment dismissing the action, leaving the EMA opinion and Commission decision intact. The Company is considering its options to appeal the decision.

18. Quarterly Financial Data (Unaudited)

The following is a summary of quarterly financial data for the years ended December 31, 2019 and 2018:

(in thousands, except for per share amounts)
Year Ended December 31, 2019

Revenues

Gross profit (1)

Income (loss) from operations

Net income (loss)

Net income (loss) per share, basic

Net income (loss) per share, diluted

Year Ended December 31, 2018

Revenues

Gross profit (1)

Income from operations

Net income

Net income per share, basic

Net income per share, diluted

First
Quarter

Second
Quarter

Third
Quarter

Fourth
Quarter

47,713 $

59,060 $

59,485 $

42,220

(2,087)

(612)

(0.01) $

52,313

9,895

11,526

0.22 $

0.21 $

52,327

10,759

100,423

1.88 $

1.84 $

43,592 $

47,350 $

49,135 $

38,680

2,442

3,066

0.07 $

0.06 $

41,739

3,913

4,611

0.09 $

43,670

6,233

7,171

0.14 $

0.13 $

60,930

54,335

4,243

4,216

0.08

53,041

46,994

9,150

10,360

0.20

0.19

(1)

Gross profit includes revenues less cost of goods sold, excluding amortization, and less intangible asset amortization.

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VANDA PHARMACEUTICALS INC.

EXHIBIT INDEX

Description

Form of Amended and Restated Certificate of Incorporation of the registrant (filed as Exhibit 3.8 to Amendment No. 2 to the registrant’s
registration statement on Form S-1 (File No. 333-130759) on March 17, 2006 and incorporated herein by reference).

Fourth Amended and Restated Bylaws of the registrant, as amended and restated on December 17, 2015 (filed as Exhibit 3.1 to the registrant’s
current report on Form 8-K (File No. 001-34186) on December 21, 2015 and incorporated herein by reference).

Specimen certificate representing the common stock of the registrant (filed as Exhibit 4.4 to Amendment No. 2 to the registrant’s registration
statement on Form S-1 (File No. 333-130759) on March 17, 2006, and incorporated herein by reference).

Amended and Restated License, Development and Commercialization Agreement, dated July 24, 2005, by and between Bristol-Myers Squibb
Company and the registrant (relating to HETLIOZ®) (filed as Exhibit 10.3 to Amendment No. 1 to the registrant’s registration Statement on
Form S-1 (File No. 333-130759) on February 16, 2006 and incorporated herein by reference).

Form of Indemnification Agreement entered into by directors and executive officers (filed as Exhibit 10.11 to the registrant’s registration
statement on Form S-1 (File No. 333-130759) on December 29, 2005 and incorporated herein by reference).

2006 Equity Incentive Plan, as amended (filed as Exhibit 10.17 to Amendment No. 2 to the registrant’s Registration Statement on Form S-1
(File No. 333-130759), as filed on March 17, 2006, and incorporated herein by reference).

Exhibit
Number

3.1

3.2

4.1

10.1#

10.2

10.3†

10.4†

Amended and Restated Employment Agreement, dated December 16, 2008, by and between Mihael H. Polymeropoulos and the registrant

(filed as Exhibit 10.34 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on August 10, 2009 and incorporated herein by
reference).

10.5†

Employment Agreement, dated December 13, 2010, by and between James Kelly and the registrant (filed as Exhibit 10.38 to the registrant’s

annual report on Form 10-K (File No. 001-34186) on March 10, 2011 and incorporated herein by reference).

10.6†

Amendment to Amended and Restated Employment Agreement, dated December 16, 2010, by and between Mihael H. Polymeropoulos and

the registrant (filed as Exhibit 10.39 to the registrant’s annual report on Form 10-K (File No. 001-34186) on March 10, 2011 and incorporated
herein by reference).

10.7

Amended and Restated Tax Indemnity Agreement, dated December 16, 2010, by and between Mihael H. Polymeropoulos and the registrant
(filed as Exhibit 10.41 to the registrant’s annual report on Form 10-K (File No. 001-34186) on March 10, 2011 and incorporated herein by
reference).

10.8

Lease, effective as of July 25, 2011, by and between Square 54 Office Owner LLC and the registrant (filed as Exhibit 10.42 to the registrant’s

quarterly report on Form 10-Q (File No. 001-34186) on November 7, 2011 and incorporated herein by reference).

10.9

10.10

Amendment to Amended and Restated License, Development and Commercialization Agreement, dated as of April 15, 2010, by and between
Bristol-Myers Squibb Company and the registrant (filed as Exhibit 10.38 to the registrant’s current report on Form 8-K (File No. 001-34186)
on April 19, 2010 and incorporated herein by reference).

Amendment to Amended and Restated License, Development and Commercialization Agreement, dated as of May 24, 2012, by and between
Bristol-Myers Squibb Company and the registrant (filed as Exhibit 10.46 to the registrant’s current report on Form 8-K (File No. 001-34186)
on May 30, 2012 and incorporated herein by reference).

10.11#

License, Development and Commercialization Agreement, dated as of April 12, 2012, by and between Eli Lilly and Company and the

registrant (filed as Exhibit 10.48 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on August 3, 2012 and incorporated
herein by reference).

10.12

Amendment to Amended and Restated License, Development and Commercialization Agreement, dated as of April 25, 2013, by and between
Bristol-Myers Squibb Company and the registrant (filed as Exhibit 10.50 to the registrant’s current report on Form 8-K (File No. 001-34186)
on April 29, 2013 and incorporated herein by reference).

100

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Exhibit
Number

10.13#

Manufacturing Agreement, dated January 24, 2014, by and between Patheon Pharmaceuticals Inc. and the registrant (relating to HETLIOZ®)
(filed as Exhibit 10.53 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on May 8, 2014 and incorporated herein by
reference).

Description

10.14

Amendment to Lease Agreement, dated March 18, 2014, by and between Square 54 Office Owner LLC and the registrant (filed as Exhibit

10.54 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on May 8, 2014 and incorporated herein by reference).

10.15

Settlement Agreement and Mutual General Release, dated December 22, 2014, by and among Novartis Pharma AG and the registrant (filed as
Exhibit 10.55 to the registrant’s annual report on Form 10-K (File No. 001-34186) on March 13, 2015 and incorporated herein by reference).

10.16#

Asset Transfer Agreement, dated December 22, 2014, by and among Novartis Pharma AG, Novartis AG and the registrant (relating to

Fanapt®) (filed as Exhibit 10.56 to the registrant’s annual report on Form 10-K/A (File No. 001-34186) on June 10, 2015 and incorporated
herein by reference).

10.17#

Sublicense Agreement, dated November 20, 1997, by and between Titan Pharmaceuticals, Inc. and Novartis Pharma AG (filed as Exhibit

10.30 to Titan Pharmaceutical Inc.’s registration statement on Form S-3 (File No. 333-42367) on December 16, 1997 and incorporated herein
by reference).

10.18#

Amendment No. 1 to Sublicense Agreement by and between Titan Pharmaceuticals, Inc. and Novartis Pharma AG, dated November 30, 1998
(filed as Exhibit 10.58 to the registrant’s annual report on Form 10-K (File No. 001-34186) on March 13, 2015 and incorporated herein by
reference).

10.19#

Amendment No. 2 to Sublicense Agreement, dated April 10, 2001, by and between Titan Pharmaceuticals, Inc. and Novartis Pharma AG (filed

as Exhibit 10.59 to the registrant’s annual report on Form 10-K/A (File No. 001-34186) on June 10, 2015 and incorporated herein by
reference).

10.20#

Amendment No. 3 to Sublicense Agreement, dated June 4, 2004, by and between Titan Pharmaceuticals, Inc. and Novartis Pharma AG (filed

as Exhibit 10.60 to the registrant’s annual report on Form 10-K (File No. 001-34186) on March 13, 2015 and incorporated herein by
reference).

10.21

Stock Purchase Agreement, dated December 22, 2014, by and between Novartis AG and the registrant (filed as Exhibit 10.61 to the

registrant’s annual report on Form 10-K (File No. 001-34186) on March 13, 2015 and incorporated herein by reference).

10.22#

License Agreement, dated December 22, 2014, by and between Novartis Pharma AG and the registrant (relating to AQW051) (filed as Exhibit

10.62 to the registrant’s annual report on Form 10-K (File No. 001-34186) on March 13, 2015 and incorporated herein by reference).

10.23†

Employment Agreement, dated September 3, 2015, by and between Gian Piero Reverberi, Senior Vice President and General Manager Europe,

and the registrant (filed as Exhibit 10.64 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on November 4, 2015 and
incorporated herein by reference).

10.24

Agreement, dated February 2, 2016, by and among Titan Pharmaceuticals, Inc., Aventisub LLC, the successor-in-interest to Aventisub II Inc.
Sanofi-Aventis and the registrant (filed as Exhibit 10.1 to the registrant’s current report on Form 8-K (File No. 001-34186) on February 4,
2016 and incorporated herein by reference).

10.25†

Vanda Pharmaceuticals Inc. Amended and Restated 2016 Equity Incentive Plan, effective as of June 13, 2018 (filed as Exhibit 10.1 to the

registrant’s registration statement on Form S-8 (File No. 333-225599) on June 13, 2018 and incorporated herein by reference).

10.26†

Form of Notice of Stock Option Grant and Stock Option Agreement under Amended and Restated 2016 Equity Incentive Plan (filed as Exhibit

10.2 to the registrant’s registration statement on Form S-8 (File No. 333-218774) on June 15, 2017 and incorporated herein by reference).

10.27†

Form of Restricted Stock Unit Award Agreement under Amended and Restated 2016 Equity Incentive Plan (filed as Exhibit 10.3 to the

registrant’s registration statement on Form S-8 (File No. 333-218774) on June 15, 2017 and incorporated herein by reference).

10.28†

UK Sub Plan under the Amended and Restated 2016 Equity Incentive Plan (filed as Exhibit 10.4 to the registrant’s registration statement on

Form S-8 (File No. 333-218774) on June 15, 2017 and incorporated herein by reference).

10.29†

Form of Stock Option Grant and Stock Option Agreement under the UK Sub Plan under the Amended and Restated 2016 Equity Incentive
Plan (filed as Exhibit 10.5 to the registrant’s registration statement on Form S-8 (File No. 333-218774) on June 15, 2017 and incorporated
herein by reference).

101

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Exhibit
Number

10.30†

Form of Restricted Stock Unit Award Agreement under the UK Sub Plan under the Amended and Restated 2016 Equity Incentive Plan (filed
as Exhibit 10.6 to the registrant’s registration statement on Form S-8 (File No. 333-218774) on June 15, 2017 and incorporated herein by
reference).

Description

10.31#

Manufacturing Agreement, dated May 6, 2016, by and between Patheon Pharmaceuticals Inc. and the registrant (relating to Fanapt®) (filed as
Exhibit 10.42 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on July 28, 2016 and incorporated herein by reference).

10.32

Second Amendment to Lease Agreement, dated June 20, 2016, by and between Square 54 Office Owner LLC and the registrant (filed as

Exhibit 10.43 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on July 28, 2016 and incorporated herein by reference).

10.33

Sublease Agreement, dated June 22, 2016, by and between Hunton & Williams LLP and the registrant (filed as Exhibit 10.44 to the

registrant’s quarterly report on Form 10-Q (File No. 001-34186) on July 28, 2016 and incorporated herein by reference).

10.34#

License Agreement, dated October 24, 2016, by and among Taro Pharmaceuticals USA, Inc., Taro Pharmaceuticals Industries Ltd. and the

registrant (filed as Exhibit 10.45 to the registrant’s annual report on Form 10-K (File No. 001-34186) on February 17, 2017 and incorporated
herein by reference).

10.35#

License Agreement, dated December 7, 2016, by and between Apotex, Inc. and the registrant (filed as Exhibit 10.46 to the registrant’s annual

report on Form 10-K (File No. 001-34186) on February 17, 2017 and incorporated herein by reference).

10.36

10.37

10.38†

10.39†

10.40†

10.41†

Third Amendment to Lease Agreement, dated March 28, 2018, by and between Square 54 Office Owner LLC and the registrant (filed as
Exhibit 10.38 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on May 2, 2018 and incorporated herein by reference).

Fourth Amendment to Lease Agreement, dated March 29, 2018, by and between Square 54 Office Owner LLC and the registrant (filed as
Exhibit 10.39 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on May 2, 2018 and incorporated herein by reference).

Amended and Restated Employment Agreement, dated April 30, 2018, by and between Gunther Birznieks and the registrant (filed as Exhibit
10.40 to the registrant’s quarterly report on Form 10-Q (File No. 001-34186) on May 2, 2018 and incorporated herein by reference).

Employment Agreement, dated August 13, 2018, by and between Timothy Williams and the registrant (filed as Exhibit 10.41 to the registrant’s
quarterly report on Form 10-Q (File No. 001-34186) on November 7, 2018 and incorporated herein by reference).

Employment Agreement, dated July 3, 2019, by and between Aranthan "AJ" Jones II and the registrant (filed as Exhibit 10.40 to the
registrant’s quarterly report on Form 10-Q (File No. 001-34186) on November 7, 2019 and incorporated herein by reference).

Employment Agreement, dated August 5, 2019, by and between Joakim Wijkstrom and the registrant (filed as Exhibit 10.41 to the registrant’s
quarterly report on Form 10-Q (File No. 001-34186) on November 7, 2019 and incorporated herein by reference).

21.1

List of Subsidiaries (filed as Exhibit 21.1 to the registrant’s annual report on Form 10-K (File No. 001-34186) on February 17, 2017 and

incorporated herein by reference).

23.1*

31.1*

31.2*

32.1*

101*

Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.

Certification of the Chief Executive Officer, as required by Section 302 of the Sarbanes-Oxley Act of 2002.

Certification of the Chief Financial Officer as required by Section 302 of the Sarbanes-Oxley Act of 2002.

Certification of the Chief Executive Officer and Chief Financial Officer as required by Section 906 of the Sarbanes-Oxley Act of 2002.

The following financial information from this annual report on Form 10-K for the fiscal year ended December 31, 2019, formatted in Inline

Extensible Business Reporting Language (iXBRL) and furnished electronically herewith: (i) Consolidated Balance Sheets as of December 31,
2019 and 2018; (ii) Consolidated Statements of Operations for the years ended December 31, 2019, 2018 and 2017; (iii) Consolidated
Statements of Comprehensive Income (Loss) for the years ended December 31, 2019, 2018 and 2017; (iv) Consolidated Statements of
Changes in Stockholders’ Equity for the years ended December 31, 2019, 2018 and 2017; (v) Consolidated Statements of Cash Flows for the
years ended December 31, 2019, 2018 and 2017; and (vi) Notes to the Consolidated Financial Statements.

102

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Exhibit
Number

Description

104

Cover Page Interactive Data File (embedded within the Inline XBRL document).

†

Indicates management contract or compensatory plan.

Confidential treatment has been granted with respect to certain provisions of this exhibit.

Filed herewith.

103

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-133368, No. 333-138070, No. 333-141571,
No. 333-148924, No. 333-156995, No. 333-164567, No. 333-171962, No. 333-179265, No. 333-186509, No. 333-193614, No. 333-201754, No. 333-209144,
No. 333-212255, No. 333-218774 and No. 333-225599) of Vanda Pharmaceuticals Inc. of our report dated February 26, 2020 relating to the financial
statements and the effectiveness of internal control over financial reporting, which appears in this Form 10-K.

Exhibit 23.1

/s/ PricewaterhouseCoopers LLP

Baltimore, Maryland
February 26, 2020

EXHIBIT 31.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Mihael H. Polymeropoulos, certify that:

I have reviewed this annual report on Form 10-K of Vanda Pharmaceuticals Inc.;

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;

Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-
15(f)) for the registrant and have:

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,
to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within
those entities, particularly during the period in which this report is being prepared;

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most
recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely
to materially affect, the registrant’s internal control over financial reporting; and

The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to
the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are
reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal
control over financial reporting.

February 26, 2020

/s/ Mihael H. Polymeropoulos, M.D.

Mihael H. Polymeropoulos, M.D.

President and Chief Executive Officer
(Principal Executive Officer)

EXHIBIT 31.2

CERTIFICATION OF CHIEF FINANCIAL OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, James P. Kelly, certify that:

I have reviewed this annual report on Form 10-K of Vanda Pharmaceuticals Inc.;

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal
control over financial reporting.

February 26, 2020

/s/ James P. Kelly

James P. Kelly
Executive Vice President, Chief Financial Officer and Treasurer
(Principal Financial Officer and Principal Accounting Officer)

CERTIFICATION OF CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)

EXHIBIT 32.1

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), each of the
undersigned officers of Vanda Pharmaceuticals Inc., (the “Company”), does hereby certify, to the best of such officer’s knowledge, that:

The Annual Report on Form 10-K for the year ended December 31, 2019 (the Form 10-K) of the Company fully complies with the requirements of
Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and the information contained in the Form 10-K fairly presents, in all material respects, the
consolidated financial condition and results of operations of the Company.

February 26, 2020

/s/ Mihael H. Polymeropoulos, M.D.

Mihael H. Polymeropoulos, M.D.
President and Chief Executive Officer
(Principal Executive Officer)

February 26, 2020

/s/ James P. Kelly

James P. Kelly
Executive Vice President, Chief Financial Officer and Treasurer
(Principal Financial Officer and Principal Accounting Officer)

A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to
the Securities and Exchange Commission (SEC) or its staff upon request. This certification “accompanies” the Form 10-K to which it relates, is not deemed
filed with the SEC and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities
Exchange Act of 1934, as amended (whether made before or after the date of the Form 10-K), irrespective of any general incorporation language contained
in such filing.