Zogenix
Annual Report 2017

Plain-text annual report

Table of Contents UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON, DC 20549_________________________________Form 10-K_________________________________xANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2017or¨TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period from to ________________________________________________________________________ Commission file number: 001-34962____________________________________ Zogenix, Inc.____________________________________ Delaware(State of Incorporation) 20-5300780(I.R.S. Employer Identification No.) 5858 Horton Street, Suite 455Emeryville, California 94608(510) 550-8300Securities registered pursuant to Section 12(b) of the Act:Common Stock, par value $0.001 per share The Nasdaq Global MarketSecurities registered pursuant to Section 12(g) of the Act:NoneIndicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes x No ¨Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange Act. Yes ¨ No xIndicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No ¨Indicate by check mark whether the registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted and postedpursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and postsuch files). x Yes ¨ NoIndicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of the registrant’sknowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. xIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.See definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.Large accelerated filer ¨ Accelerated filer xNon-accelerated filer o (Do not check if a smaller reporting company) Smaller reporting company oEmerging growth company o If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financialaccounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨ No xAs of June 30, 2017, the aggregate market value of the registrant’s common stock held by non-affiliates of the registrant was approximately $229.7 million, based on the closingprice of the registrant’s common stock on the Nasdaq Global Market of $14.50 per share.As of February 28, 2018, there were 34,807,509 shares of the registrant’s common stock outstanding.DOCUMENTS INCORPORATED BY REFERENCEPortions of the registrant’s definitive proxy statement relating to its 2018 annual meeting of shareholders (the “2018 Proxy Statement”) are incorporated by reference into Part III ofthis Annual Report on Form 10-K where indicated. The 2018 Proxy Statement will be filed with the U.S. Securities and Exchange Commission within 120 days after the end of thefiscal year to which this report relates. Table of ContentsZOGENIX, INC.FORM 10-KFor the Year Ended December 31, 2017Table of Contents PagePART I Item 1Business3Item 1ARisk Factors18Item 1BUnresolved Staff Comments45Item 2Properties45Item 3Legal Proceedings46Item 4Mine Safety Disclosures46 PART II Item 5Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities47Item 6Selected Financial Data49Item 7Management’s Discussion and Analysis of Financial Condition and Results of Operations51Item 7AQuantitative and Qualitative Disclosures About Market Risk65Item 8Financial Statements and Supplementary Data65Item 9Changes in and Disagreements With Accountants on Accounting and Financial Disclosure65Item 9AControls and Procedures66Item 9BOther Information68 PART III Item 10Directors, Executive Officers and Corporate Governance69Item 11Executive Compensation69Item 12Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters69Item 13Certain Relationships, Related Transactions and Director Independence69Item 14Principal Accounting Fees and Services69 PART IV Item 15Exhibits, Financial Statement Schedules70 Signatures iTable of ContentsPART IForward-Looking Statements and Market DataThis Annual Report on Form 10-K and the information incorporated herein by reference contain forward-looking statements that involve substantialrisks and uncertainties. These forward looking statements include, but are not limited to, statements about:•the progress and timing of clinical trials of ZX008;•the safety and efficacy of our product candidates;•the timing of submissions to, and decisions made by, the U.S. Food and Drug Administration, or FDA, and other regulatory agencies, including foreignregulatory agencies, with regards to the demonstration of the safety and efficacy of our product candidates to the satisfaction of the FDA and such otherregulatory agencies;•our ability to obtain, maintain and successfully enforce adequate patent and other intellectual property protection of our product candidates and theability to operate our business without infringing the intellectual property rights of others;•the goals of our development activities and estimates of the potential markets for our product candidates, and our ability to compete within thosemarkets;•our ability to obtain and maintain adequate levels of coverage and reimbursement from third-party payors for any of our product candidates that may beapproved for sale, the extent of such coverage and reimbursement and the willingness of third-party payors to pay for our products versus less expensivetherapies;•the impact of healthcare reform laws; and•projected cash needs and our expected future revenues, operations and expenditures.The forward-looking statements are contained principally in the sections entitled “Risk Factors,” “Management’s Discussion and Analysis of FinancialCondition and Results of Operations” and “Business.” In some cases, you can identify forward-looking statements by the following words: “may,” “will,”“could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “ongoing” or thenegative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements relate to futureevents or our future financial performance or condition and involve known and unknown risks, uncertainties and other factors that could cause our actualresults, levels of activity, performance or achievement to differ materially from those expressed or implied by these forward-looking statements. We discussmany of these risks, uncertainties and other factors in this Annual Report on Form 10-K in greater detail under the heading “Item 1A — Risk Factors.”Given these risks, uncertainties and other factors, we urge you not to place undue reliance on these forward-looking statements, which speak only as ofthe date of this report. You should read this Annual Report on Form 10-K completely and with the understanding that our actual future results may bematerially different from what we expect. For all forward-looking statements, we claim the protection of the safe harbor for forward-looking statementscontained in the Private Securities Litigation Reform Act of 1995. We undertake no obligation to revise or update publicly any forward-looking statements,whether as a result of new information, future events or otherwise, unless required by law.This Annual Report on Form 10-K also contains estimates, projections and other information concerning our industry, our business, and the markets forZX008 and other product candidates, including data regarding the estimated size of those markets, their projected growth rates, the incidence of certainmedical conditions, statements that certain drugs, classes of drugs or dosages are the most widely prescribed in the United States or other markets, theperceptions and preferences of patients and physicians regarding certain therapies and other prescription, prescriber and patient data, as well as data regardingmarket research, estimates and forecasts prepared by our management. Information that is based on estimates, forecasts, projections, market research or similarmethodologies is inherently subject to uncertainties and actual events or circumstances may differ materially from events and circumstances reflected in thisinformation. Unless otherwise expressly stated, we obtained this industry, business, market and other data from reports, research surveys, studies and similardata prepared by market research firms and other third parties, industry, medical and general publications, government data and similar sources. In particular,unless otherwise specified, all prescription, prescriber and patient data in this Annual Report on Form 10-K is from Source Healthcare Analytics, Source®Pharmaceutical Audit Suite (PHAST) Institution/Prescription, Source® PHAST Prescription, Source® Prescriber or Source® Dynamic Claims. In some cases, wedo not expressly refer to the sources from which this data is derived. In that regard, when we refer to one or more sources of this type of data in any paragraph,you should assume that other data of this type appearing in the same paragraph is derived from the same sources, unless otherwise expressly stated or thecontext otherwise requires.DosePro® and Zogenix™ are our trademarks. All other trademarks, trade names and service marks appearing in this Annual Report on Form 10-K are theproperty of their respective owners. Use or display by us of other parties’ trademarks,1Table of Contentstrade dress or products is not intended to and does not imply a relationship with, or endorsements or sponsorship of, us by the trademark or trade dress owner.Unless the context requires otherwise, references in this Annual Report on Form 10-K to “Zogenix,” “we,” “us” and “our” refer to Zogenix, Inc.,including its consolidated subsidiaries.2Table of ContentsItem 1. BusinessCompany OverviewZogenix, Inc. (“Zogenix” or “we” or “the Company”) is a pharmaceutical company developing and commercializing innovative central nervoussystem (“CNS”) therapies for people living with serious and life-threatening rare CNS disorders and medical conditions. Our current primary area oftherapeutic focus is rare, or “orphan” childhood-onset epilepsy disorders.We currently own and control worldwide development and commercialization rights to ZX008, our lead Phase 3 product candidate. ZX008 is low-dose fenfluramine for the treatment of seizures associated with two rare and catastrophic forms of childhood-onset epilepsy: Dravet syndrome and Lennox-Gastaut syndrome (“LGS”).Dravet syndrome is a rare form of pediatric-onset epilepsy with life threatening consequences for patients and for which current treatment options arevery limited. ZX008 has received orphan drug designation in the United States and the European Union (“the EU”) for the treatment of Dravet syndrome. Inaddition, ZX008 for the treatment of Dravet syndrome received Fast Track designation from the U.S. Food and Drug Administration (the “FDA”) in January2016 and Breakthrough Therapy designation in February 2018.We initiated our Phase 3 clinical trials in North America (Study 1501) in January 2016 and in Europe and Australia in June 2016 (Study 1502). Study1501 and Study 1502 are each identical randomized, double-blind, placebo-controlled studies of ZX008 as adjunctive therapy for patients with uncontrolledseizures who have Dravet syndrome. In January 2017, we announced our plan to report top-line results from Study 1501 and Study 1502 via a prospectivemerged study analysis approach whereby top-line results from the first approximately 120 subjects randomized into either Study 1501 or 1502 would havetheir study results analyzed and be reported initially as “Study 1.” In April 2017, we completed enrollment of Study 1 and, in September 2017, we announcedpositive top-line results for the 119 patients included in the Study 1 Phase 3 trial. The Study 1 trial met its primary objective of demonstrating that ZX008, ata dose of 0.8 mg/kg/day, is superior to placebo as adjunctive therapy in the treatment of Dravet syndrome in children and young adults based on change inthe frequency of convulsive seizures between the 6-week baseline observation period and the 14-week treatment period (p<0.001). In the trial, ZX008 at adose of 0.8 mg/kg/day also demonstrated statistically significant improvements versus placebo in all key secondary measures, including the proportion ofpatients with clinically meaningful reductions in seizure frequency (50% or greater) and longest seizure-free interval. The same analyses comparing a 0.2mg/kg/day ZX008 dose versus placebo also demonstrated statistically significant improvement compared with placebo. ZX008 was generally well toleratedwithout any signs or symptoms of valvulopathy or pulmonary hypertension.In September 2016, we initiated Part 1 of Study 1504, a two-part, double blind, randomized, two arm pivotal Phase 3 clinical trial of ZX008 in Dravetsyndrome patients who are taking stiripentol, valproate and/or clobazam as part of their baseline standard care. Part 1 investigated the pharmacokineticprofile and safety of ZX008 when co-administered with the stiripentol regimen (stiripentol, valproate and clobazam). Based on the results of thepharmacokinetic and safety portion of the trial, in February 2017 we initiated the safety and efficacy portion of Study 1504, a two-arm study that comparesZX008 versus placebo across the titration and 12-week maintenance periods at multiple sites, which currently includes sites in France, the Netherlands,United States, Canada, Germany, the United Kingdom and Spain. Study 1504 is targeted to enroll approximately 40 patients per treatment group. In January2018, we completed enrollment of this study and expect to report top-line results from the trial in the second quarter of 2018. We believe we are on track tosubmit applications for regulatory approvals for ZX008 in the United States and Europe in the fourth quarter of 2018.LGS is another rare, refractory, debilitating pediatric-onset epilepsy with life threatening consequences for patients and for which current treatmentoptions are very limited and suboptimal. Beginning in first quarter of 2016, we funded an open-label, dose-finding, investigator-initiated study of theeffectiveness and tolerability of ZX008 as an adjunctive therapy in patients with LGS. In December 2016, we presented initial data from an interim analysisof the first 13 patients to have completed at least 12 weeks of this Phase 2 clinical trial at the 70th Annual Meeting of the American Epilepsy Society. Thesedata demonstrated that ZX008 provided clinically meaningful improvement in major motor seizure frequency in patients with severe refractory LGS, with 7out of 13 patients (54%) achieving at least a 50% reduction in the number of major motor seizures, at doses below the 0.8 mg/kg/day maximum allowed dose.In addition, ZX008 was generally well tolerated without any observed signs or symptoms of valvulopathy or pulmonary hypertension. We believe these dataindicate that ZX008 has the potential to be a safe and effective adjunctive treatment of major motor seizures for patients with LGS. Based on the strength ofthe LGS data generated, in the first quarter of 2017, we submitted an investigational new drug, or IND, application to the FDA to initiate a Phase 3 program ofZX008 in LGS, which became effective in April 2017. In November 2017, we announced the initiation of our multicenter global Phase 3 clinical trial ofZX008 as an adjunctive treatment for seizures in patients with LGS (Study 1601) with the enrollment of the first patient into the study. In the first half of2017, ZX008 received orphan drug designation for the treatment of LGS from the FDA in the United States and the European Medicines Agency (the “EMA”)in the EU.3Table of ContentsIn April 2015, we sold our Zohydro ER business to enable us to focus on development of our CNS rare disease product candidates and to enhance ourfinancial strength. Zohydro ER (hydrocodone bitartrate) is an extended-release capsule oral formulation of hydrocodone without acetaminophen.In May 2014, we sold our Sumavel DosePro (sumatriptan injection) Needle-free Delivery System business to affiliates of Endo International plc, orEndo. In connection with the sale, we entered into a supply agreement to manufacture and supply Sumavel DosePro to Endo (the “Endo Supply Agreement”).Under this agreement, we provided contract manufacturing services and supplied Sumavel DosePro to Endo through April 2017. The supply agreement wasterminated in September 2017.Our StrategyWe are committed to developing and commercializing therapeutic solutions for people living with serious and life-threatening rare CNS disorders andmedical conditions. Our strategy centers on developing and advancing our lead therapeutic product candidate, ZX008, low-dose fenfluramine for thetreatment of Dravet syndrome, LGS, and potentially other rare and catastrophic epilepsy disorders. In addition to ZX008, we aim to identify, develop, andadvance other innovative therapeutic product candidates with the potential to treat patients living with serious and life-threating rare CNS disorders. The keyelements of our strategy are:•Rapidly advancing ZX008 for the treatment of Dravet syndrome through clinical development and regulatory approval. In September 2017, weannounced positive top-line results for our first Phase 3 trial (Study 1) studying ZX008 as adjunctive therapy for patients with uncontrolled convulsiveseizures who have Dravet syndrome. We are currently conducting a second double-blind, randomized, two-arm pivotal Phase 3 trial for ZX008 as anadjunctive treatment in Dravet syndrome, Study 1504, in which all patients will be taking stiripentol, valproate and/or clobazam as part of their baselinestandard care. We expect to report top-line results from Study 1504 in the second quarter of 2018, and if positive, submit applications for regulatoryapprovals in the U.S. and Europe in the fourth quarter of 2018.•Developing ZX008 for the treatment of Lennox-Gastaut syndrome. In November 2017, we announced the initiation of our multicenter global Phase 3clinical trial for ZX008 as an adjunctive treatment of seizures associated with LGS with the enrollment of the first patient into the study. In the first half of2017, ZX008 received orphan drug designation for the treatment of LGS from the FDA in the United States and the European Medicines Agency in the EU.•Evaluating ZX008 for potential treatment of other forms of orphan pediatric epilepsy. In addition to Dravet syndrome and LGS, we believe that theunique mechanism of action of ZX008 has the potential to treat other epileptic encephalopathies where there is a significant unmet medical need. Weexpect to continue to evaluate its potential in additional orphan pediatric-onset epilepsy indications where there is a significant unmet medical need.•Identifying innovative, differentiated product development candidates in the therapeutic area of rare CNS disorders for acquisition and furtherdevelopment. Our business development team focuses on identifying and evaluating differentiated, high-value licensing and product acquisitionopportunities that would build our CNS product candidate pipeline and effectively leverage our capabilities in the United States and Europe. Our Clinical Product CandidateWe currently have one product candidate in clinical development for differentiated therapies treating CNS disorders.ZX008 (Low-Dose Fenfluramine) for the Treatment of Dravet SyndromeDravet syndrome is a rare childhood-onset channelopathy in which intractable epilepsy is one of the most significant and devastatingsymptoms. Children and young adults with Dravet syndrome experience debilitating, persistent and potentially life-threatening seizures beginning in thefirst year of life. Seizures continue throughout their lifetime and are most often treatment resistant, meaning that currently available medications andtherapies are not able to achieve complete or clinically meaningful seizure control and, in some cases, worsen the condition. Individuals with Dravetsyndrome face a higher incidence of Status Epilepticus and Sudden Unexplained Death in Epilepsy, or SUDEP. These patients suffer from severe cognitiveand other developmental impairment throughout life, as well as neurobehavioral disorders such as autistic-like behavior and attention deficit hyperactivitydisorder, and motor abnormalities. The prognosis for patients with Dravet syndrome to become seizure free is poor. A recent study by Wu et. al. published bythe American Academy of Pediatrics in 2015 reported an incidence rate for Dravet syndrome of approximately 1 per 16,000 live births with onset occurringwithin the first year of life.There are currently no FDA-approved treatments indicated for the treatment of seizures associated with Dravet syndrome. The standard of care usuallyinvolves a combination of the following anticonvulsant drugs: clobazam, clonazepam, levetiracetam, topiramate, valproic acid, ethosuximide andzonisamide. Stiripentol is approved in Europe, Canada, Australia and Japan for the treatment of seizures associated with Dravet syndrome in conjunction withvalproate and/or clobazam. In4Table of ContentsEurope, stiripentol was granted an orphan drug designation for the treatment of Dravet syndrome in 2001. In the United States, stiripentol is not FDA-approved and can only be obtained via the FDA’s Personal Importation Policy (“PIP”) or under an Expanded Access IND. Sodium channel blockinganticonvulsant drugs often used to treat most other epilepsy conditions increase seizure frequency in patients with Dravet syndrome. Management of thisdisease may also include a nonpharmacologic treatments, including ketogenic diet and vagal nerve stimulation.Fenfluramine was originally developed and approved as an anorectic agent for the treatment of adult obesity. Pre-clinical and clinical evidence of thedrug’s ability to treat refractory pediatric epileptic seizures was first described in the 1980s. Fenfluramine was withdrawn from the market in 1997 because therisk outweighed the benefit in this adult obese population, after cases of heart valve defects and pulmonary hypertension were reported in adults who hadtaken fenfluramine, most often with phentermine. However, at this time, academic pediatric neurologists in Belgium continued to evaluate low doses offenfluramine in a small number of refractory patients under a government approved compassionate use protocol. Their open-label study, which continuestoday, evaluated the safety and effectiveness of low-dose fenfluramine to reduce seizures in refractory Dravet syndrome patients.In December 2016, we presented the most recent analyses of the original Dravet syndrome patients being treated in Belgium under this governmentapproved protocol at the 70th Annual Meeting of the American Epilepsy Society. At that time ten original patients who started treatment with fenfluramineprior to 2010 had been treated with low-dose fenfluramine for a mean of 17.5 years (range: 7-28 years) From the analysis, low-dose fenfluramine, as anadjunctive therapy to standard antiepileptic drugs, was providing these difficult to treat patients with long-term, durable seizure control. As reported at themeeting, for the most immediate past six years of treatment leading up to the analysis, three patients were seizure-free for the entire six years and four patientsexperienced seizure-free intervals of at least two years. None of these patients developed any clinically meaningful signs or symptoms of cardiacvalvulopathy or pulmonary hypertension, while two patients had mild and stable cardiac valve thickening on the most recent cardiac echocardiogram thatwas deemed to be clinically unimportant. After 2010, an additional 11 Dravet syndrome patients started adjuvant treatment with low-dose fenfluramine underthe Belgium government approved protocol and data on this cohort was presented at the 71st Annual Meeting of the American Epilepsy Society. The meanage at start of fenfluramine in this cohort was 12.5 years (range, 1- 30 years) and treatment with fenfluramine was for a median duration of 3.0 years (range, 1-7 years). Ninety-one percent of these patients had a clinically meaningful reduction (≥50%) and 73% had substantial reductions (≥75%) in major motorseizure frequency at the prior visit. Fenfluramine was generally well tolerated with no clinical and/or echocardiographic signs of cardiac valvulopathy orpulmonary hypertension. In this ongoing Belgian study of low dose fenfluramine treating refractory Dravet syndrome patients, no patient has stoppedtreatment for any adverse event.Because of the known cardiac side effects of fenfluramine reported when prescribed in higher doses for the treatment of adult obesity (without baselinecardiac data), the ongoing Belgian study requires ongoing periodic evaluations of the heart and, in particular, the heart valves and measures assessing for thepresence of pulmonary hypertension using echocardiography. Overall, low-dose fenfluramine has been shown to be well tolerated and side-effects oftreatment have been mild and transient over the entire 29-year study period. There have been no clinically significant findings related to cardiacvalvulopathy and no reports of pulmonary hypertension in any ZX008 or low-dose fenfluramine studies to date.Formal meetings have been held with the regulatory agencies in the United States and EU to obtain concurrence on remaining pre-clinical and clinicalrequirements for regulatory approval. Based upon this information, we believe our two pivotal placebo-controlled Phase 3 studies in Dravet syndrome, ifsuccessful, will support regulatory approval of ZX008 in the United States and in Europe. Our investigational new drug (“IND”) application for ZX008 for thetreatment of Dravet syndrome became effective in December 2015. We initiated our Phase 3 clinical trials in North America (Study 1501) in January 2016and in Europe and Australia in June 2016 (Study 1502). Study 1501 and Study 1502 are each identical randomized, double-blind, placebo-controlled studiesof ZX008 as adjunctive therapy for patients with uncontrolled seizures who have Dravet syndrome. In January 2017, we announced our plan to report top-line results from Study 1501 and Study 1502 via a prospective merged study analysis approach whereby top-line results from the first approximately 120subjects randomized into either Study 1501 or 1502 would have their study results analyzed and be reported initially as “Study 1.” In April 2017, wecompleted enrollment of Study 1 and, in September 2017, we announced positive top-line results for the 119 patients included in the Study 1 Phase 3 trial.The Study 1 trial met its primary objective of demonstrating that ZX008, at a dose of 0.8 mg/kg/day, is superior to placebo as adjunctive therapy in thetreatment of Dravet syndrome in children and young adults based on change in the frequency of convulsive seizures between the 6-week baselineobservation period and the 14-week treatment period (p<0.001). In the trial ZX008 0.8 mg/kg/day also demonstrated statistically significant improvementsversus placebo in all key secondary measures, including the proportion of patients with clinically meaningful reductions (50% or greater) in convulsiveseizure frequency and longest seizure-free interval. The same analyses comparing a 0.2 mg/kg/day ZX008 dose versus placebo also demonstrated statisticallysignificant improvement compared with placebo. Patients completing the Phase 3 trials are given the opportunity to enroll in an open label long-termextension safety study (Study 1503).5Table of ContentsWe are conducting Study 1504 in Dravet syndrome patients who are incomplete responders to a stiripentol treatment regimen. In September 2016, weinitiated Part 1 of Study 1504, a two-part, double blind, randomized, two arm pivotal Phase 3 clinical trial of ZX008 in Dravet syndrome patients who aretaking stiripentol, valproate and/or clobazam as part of their baseline standard care. Part 1 investigated the pharmacokinetic profile and safety of ZX008when co-administered with the stiripentol regimen (stiripentol, valproate and clobazam). Based on the results of the pharmacokinetic and safety portion ofthe trial, in February 2017, we initiated the safety and efficacy portion of Study 1504, a two-arm study that compares ZX008 versus placebo across thetitration and 12-week maintenance periods at multiple sites, which currently includes sites in France, the Netherlands, United States, Canada, Germany, theUnited Kingdom and Spain. Study 1504 is targeted to enroll approximately 40 patients per treatment group. We completed enrollment of this study inJanuary 2018 and expect to report top-line results from Study 1504 in the second quarter of 2018. We believe in addition to Study 1504 being a pivotalPhase 3 trial, it may also demonstrate the potential incremental benefit of ZX008 over the background stiripentol regimen, which is required to maintainZX008 orphan drug status in the EU. We also expect the results of Study 1504 will be important for future market positioning and reimbursement of ZX008in Europe.In the event that the FDA requires a risk evaluation and mitigation strategy (“REMS”) to ensure that the benefits of the drug outweigh the potentialrisks, we are currently developing the appropriate elements of a specific REMS to support and maintain a long-term favorable benefit-risk profile for ZX008in the United States, as well as a similar risk mitigation plan, or RMP for Europe. This is consistent with other drugs with known safety issues that areapproved for serious diseases with high unmet need. We intend to submit a new drug application (“NDA”) and a marketing authorization application(“MAA”) for ZX008 for the treatment of Dravet syndrome in the fourth quarter of 2018.ZX008 for the Treatment of Lennox-Gastaut SyndromeLGS is a severe, refractory and debilitating form of epilepsy that typically becomes apparent during early childhood. Affected children experiencegeneralized tonic-clonic seizures, tonic seizures, atonic seizures, and tonic/atonic seizures, all of which can result in “drop attacks.” Other seizure types thatoccur in some LGS patients include non-convulsive seizures, such as atypical absences, focal seizures, and myoclonic seizures. Children with LGS most oftenalso develop cognitive dysfunction, delays in reaching developmental milestones and behavioral problems. LGS can be caused by a variety of underlyingconditions, but in some cases no cause can be identified.LGS makes up 1% to 4% of all pediatric epilepsies. There is no specific therapy for LGS that is effective in all cases and the disorder has provenparticularly resistant to most currently available therapeutic options. The three main therapeutic options for the treatment of LGS are anti-epileptic drugs(“AEDs”), dietary therapy (typically the ketogenic diet) or surgery (VNS therapy or corpus callosotomy). AEDs are usually prescribed to individuals withLGS, but the individual response is highly variable. However, because individuals with LGS rarely respond successfully to one AED, they most often requirepolypharmacotherapy with multiple AEDs, and yet still most continue to have refractory seizures. Although a variety of specific drugs have been approvedby the FDA and/or EMA for the treatment of LGS including topiramate, lamotrigine, clobazam, rufinamide, felbamate and clonazepam, these medicationstypically have limited success and in addition, are often associated with intolerable side effects, especially in individuals who receive multidrug, high-doseregimens. Furthermore, all current AEDs can also become less effective over time.Beginning in first quarter of 2016, we funded an open-label dose-ranging investigator-initiated study of the effectiveness and tolerability of ZX008 asan adjunctive therapy in patients with LGS. Refractory LGS patients were treated with ZX008 as an adjunctive therapy for seizures associated with LGS. InDecember 2016, we presented initial data from an interim analysis of the first 13 patients to have completed at least 12 weeks of this Phase 2 open-label,dose-finding study at the 70th Annual Meeting of the American Epilepsy Society. These data demonstrated that ZX008 provided clinically meaningfulimprovement in major motor seizure frequency in patients with severely refractory LGS, despite not attempting to dose to maximal efficacy as per protocol,with 7 of 13 patients (54%) achieving at least a 50% reduction in the number of major motor seizures, at doses below the 0.8 mg/kg/day maximum alloweddose. In addition, ZX008 was generally well tolerated without any observed signs or symptoms of valvulopathy or pulmonary hypertension. We believe thesedata indicate that ZX008 has the potential to be a safe and effective adjunctive treatment for LGS.Based on the strength of the LGS data generated in the investigator-initiated study, in November 2017 we announced the initiation of our global Phase3 clinical trial for ZX008 as an adjunctive treatment of seizures associated with LGS, Study 1601. Study 1601 is divided in two parts. Part 1 is a double-blind,placebo-controlled investigation to assess the safety, tolerability and efficacy of ZX008, low-dose fenfluramine, when added to a patient’s current anti-epileptic therapy. The trial will include two dose levels of ZX008 (0.2 mg/kg/day and 0.8 mg/kg/day, up to a maximum daily dose of 30 mg), as well asplacebo. After establishing baseline seizure frequency for 4 weeks, randomized patients will be titrated to their dose over a 2-week titration6Table of Contentsperiod, followed by a 12-week fixed dose maintenance period. The Company is targeting a total of 225 randomized patients (75 per treatment arm) in thetrial. The primary endpoint of Study 1601 is change in the number of seizures that result in drops between baseline and the combined titration andmaintenance periods at the 0.8 mg/kg/day dose as compared to placebo. The key secondary endpoints include change in the number of seizures that result indrops between baseline and the combined titration and maintenance periods at the 0.2 mg/kg/day dose, and the proportion of patients achieving at least a50% reduction in drop seizures. Part 2 of Study 1601 will be a 12-month open-label extension to evaluate the long-term safety, tolerability and effectivenessof ZX008. ZX008 for the treatment of LGS has been designated as an orphan drug by both the FDA and the European Commission. Study 1601 is planned forup to 85 sites in North America, Europe, Asia-Pacific, South America, South Africa and Australia.Beyond Dravet syndrome and LGS, we also intend to evaluate ZX008’s potential to treat additional indications in other rare pediatric-onset epilepticencephalopathies and related medical conditions in the future.CompetitionThe pharmaceutical industry is characterized by rapidly advancing technologies, intense competition and a strong emphasis on proprietarytherapeutics. We face competition from a number of sources, some of which may target the same indications as our product candidates, including largepharmaceutical companies, smaller biopharmaceutical companies, biotechnology companies, academic institutions, government agencies and private andpublic research institutions, many of which have greater financial resources, research and development capabilities, sales and marketing capabilities,manufacturing capabilities, experience in obtaining regulatory approvals for product candidates and/or other resources than us. We will face competition notonly in the commercialization of any product candidates for which we obtain marketing approval from the FDA or other regulatory authorities, but also forthe in-licensing or acquisition of additional product candidates.ZX008There are currently no FDA-approved treatments indicated for the treatment of seizures associated with Dravet syndrome. The standard of care usuallyinvolves a combination of the following anticonvulsant drugs: clobazam, clonazepam, levetiracetam, topiramate, valproic acid, ethosuximide andzonisamide. Stiripentol is approved in Europe, Canada, Australia and Japan for the treatment of Dravet syndrome when used in conjunction with valproateand/or clobazam. In Europe, stiripentol was granted an orphan drug designation for the treatment of Dravet syndrome in 2001. In the United States, stiripentolis not FDA approved and can only be obtained via the FDA’s Personal Importation Policy, or PIP, or under an Expanded Access IND. The FDA’s PIP isintended to make available, through the exercise of enforcement discretion, unapproved drugs used to treat serious medical conditions for which noequivalent treatment exists in the United States, and unapproved drugs used to continue treatment begun in a foreign country. All new patients obtainingstiripentol must have a patient specific IND application submitted to the FDA by the prescribing physician, who is most often an academic pediatricneurologist. The manufacturer of stiripentol, Biocodex, may in the future seek and receive FDA approval for stiripentol for the treatment of Dravet syndrome.ZX008 has a novel mechanism of action (selective serotonin activity and possibly sigma-1 activity) that is different from the other antiepileptic drugscurrently available and in clinical development in the United States and EU for the treatment of epileptic encephalopathies like Dravet syndrome. Two otherdrug candidates in clinical development for the treatment of Dravet syndrome are both cannabinoids which have a different distinct mechanism of actionfrom ZX008. We do not expect that their successful development and approval in the United States or Europe would block the FDA or EMA from grantingapproval of ZX008 even if they are approved prior to ZX008.One cannabinoid product candidate in clinical development for Dravet syndrome is GW Pharmaceuticals’ Epidiolex, a liquid drug formulation of plant-derived purified cannabidiol, or CBD, a component of marijuana. Published open-label clinical data and anecdotal evidence has suggested that patients withDravet syndrome experience a reduction in seizures when CBD is prescribed to them. In March 2016, GW Pharmaceuticals announced positive results fromits first Phase 3 clinical trial for Epidiolex for the treatment of Dravet syndrome, and in June and September 2016 announced positive results from its twoPhase 3 clinical trials for Epidiolex for the treatment of LGS, with Epidiolex achieving its primary study endpoints in all three trials. GW Pharmaceuticals iscurrently conducting an additional Phase 3 study in Dravet syndrome and in December 2017 announced data from the second Phase 3 study in Dravetsyndrome is expected in the second half of 2018. Also in December 2017, GW Pharmaceuticals announced FDA acceptance of its NDA filing for Epidiolex inthe treatment of LGS and Dravet syndrome and that an MAA for Epidiolex in both indications had been filed in Europe.Insys Therapeutics, or Insys, is developing a synthetic cannabidiol, or CBD, for the treatment of pediatric epilepsies, including Dravet syndrome. Insyspreviously advanced its synthetic CBD program, which has received orphan drug designation7Table of Contentsand Fast Track status by the FDA for use of CBD as a potential treatment for Dravet syndrome, into a Phase 1/2 clinical trial. Insys initiated Phase 2development of its CBD product candidate for childhood absence epilepsy in December of 2017, and plans to initiate a Phase 3 trial in infantile spasms, apediatric epilepsy syndrome, in the first quarter of 2018.Several other companies, including Xenon Pharmaceuticals, Inc. have disclosed that they are developing preclinical drug candidates for the potentialtreatment of Dravet syndrome.Manufacturing and SupplyIn September 2017, our agreement to manufacture and supply Sumavel DosePro to Endo was terminated. We do not own or operate, and currently haveno plans to establish or own any manufacturing facilities with respect to the manufacture of ZX008 or any future product candidates. We currently rely, andexpect to continue to rely, on third-party manufacturers to produce sufficient quantities of our product candidates and their component raw materials for usein our internal research efforts and clinical trials and in relation to any future commercialization of our product candidates. Our third-party manufacturers areresponsible for obtaining the raw materials necessary to manufacture our product candidates, which we believe are readily available from more than onesource. Additional third-party manufacturers are and will be used to formulate, fill, label, package and distribute investigational drug products. This approachallows us to maintain a more efficient infrastructure while enabling us to focus our expertise on developing and commercializing our product candidates.Although we believe we have multiple potential sources for the manufacture of our product candidates and their related raw materials, we currently rely onsingle manufacturers for different aspects of ZX008.License AgreementsZogenix International Limited Sales and Purchase Agreement (ZX008)Under the terms of our agreement to acquire Zogenix International Limited, pursuant to a sale and purchase agreement with Brabant Pharma Limited(Brabant), we agreed to make future milestone payments to the former principals of Brabant of up to $95.0 million in the event we achieve contractuallyspecified regulatory and sales milestones with respect to ZX008. We agreed to use commercially reasonable efforts to develop and commercialize ZX008 andto achieve the milestones.In addition, in October 2014, Zogenix International Limited has a collaboration and license agreement with the Universities of Antwerp and Leuven inBelgium (the “Universities”), which runs through September 2045. Under the terms of the agreement, the Universities granted Zogenix International Limitedan exclusive worldwide license to use the data obtained from the study, as well as certain intellectual property related to fenfluramine for the treatment ofDravet syndrome. Zogenix International Limited is required to pay a mid-single-digit percentage royalty on net sales of fenfluramine for the treatment ofDravet syndrome or, in the case of a sublicense of fenfluramine for the treatment of Dravet syndrome, a percentage in the mid-twenties of the sub-licensingrevenues. The agreement may be terminated by the Universities if Zogenix International Limited: (a) does not use commercially reasonable efforts to (i)develop and commercialize fenfluramine for the treatment of Dravet syndrome or related conditions stemming from infantile epilepsy, or (ii) seek approval offenfluramine for the treatment of Dravet syndrome in the United States; or (b) if Zogenix International Limited becomes insolvent, shall make an assignmentfor the benefit of creditors, or shall have a petition in bankruptcy filed for or against it or if a petition for any similar relief has been filed against it. TheCompany can terminate the agreement upon specified prior written notice to the Universities.Intellectual PropertyOur success will depend to a significant extent on our ability to obtain, expand and protect our intellectual property estate, enforce patents, maintaintrade secret and trademark protection and operate without infringing the proprietary rights of other parties.ZX008As of December 31, 2017, we have rights to 4 issued U.S. patents. These patents, entitled “Method for the Treatment of Dravet Syndrome,” cover claimsrelated to a method for adjunctive treatment of seizures associated with Dravet syndrome with ZX008 and are expected to provide protection of theassociated claims through 2033. There are currently 21 pending U.S. patent applications (which includes nine provisional applications); and 33 pendingforeign applications (which includes one allowed European application and five Patent Cooperation Treaty applications) in the ZX008 series of patent cases.Our pending patent applications may not result in the issuance of any additional patents.Government Regulation8Table of ContentsFDA Approval ProcessIn the United States, pharmaceutical products are subject to extensive regulation by the FDA. The Federal Food, Drug, and Cosmetic Act, or FFDCA,and other federal and state statutes and regulations govern, among other things, the research, development, testing, manufacture, storage, recordkeeping,approval, labeling, promotion and marketing, distribution, post-approval monitoring and reporting, sampling and import and export of pharmaceuticalproducts. Failure to comply with applicable FDA or other requirements may subject a company to a variety of administrative or judicial sanctions, such as theFDA’s refusal to approve pending applications, a clinical hold, warning letters, recall or seizure of products, partial or total suspension of production,withdrawal of the product from the market, injunctions, fines, civil penalties or criminal prosecution.FDA approval is required before any new drug or dosage form, including a new use of a previously approved drug, can be marketed in the United States.The process required by the FDA before a drug may be marketed in the United States generally involves:•completion of pre-clinical laboratory and animal testing and formulation studies in compliance with the FDA’s current good laboratory practice, orGLP, regulations;•submission to the FDA of an IND for human clinical testing which must become effective before human clinical trials may begin in the UnitedStates;•performance of adequate and well-controlled human clinical trials in accordance with current good clinical practice, or GCP, regulations, toestablish the safety and efficacy of the proposed drug product for each intended use;•submission, review and approval to the FDA of an NDA; and•satisfactory completion of an FDA inspection of the manufacturing facility or facilities where the product is produced to assess compliance withcurrent Good Manufacturing Practice, or cGMP, requirements.The pre-clinical and clinical testing and approval process requires substantial time, effort and financial resources, and we cannot be certain that anyapprovals for our product candidates will be granted on a timely basis, if at all. Pre-clinical tests include laboratory evaluation of product chemistry,formulation, stability and toxicity, as well as animal studies to assess the characteristics and potential safety and efficacy of the product. The results of pre-clinical tests, together with manufacturing information, analytical data and a proposed clinical trial protocol and other information, are submitted as part ofan IND to the FDA. Some pre-clinical testing may continue even after the IND is submitted. The IND automatically becomes effective 30 days after receipt bythe FDA, unless the FDA, within the 30-day time period, raises concerns or questions relating to one or more proposed clinical trials and places a trial onclinical hold, including concerns that human research subjects will be exposed to unreasonable health risks. In such a case, the IND sponsor and the FDAmust resolve any outstanding concerns before the clinical trial can begin. As a result, our submission of an IND may not result in FDA authorization tocommence a clinical trial. A separate submission to an existing IND must also be made for each successive clinical trial conducted during productdevelopment.Clinical trials involve the administration of an investigational drug to human subjects under the supervision of qualified investigators in accordancewith GCP requirements, which include the requirement that all research subjects provide their informed consent in writing for their participation in anyclinical trial. For purposes of an NDA submission and approval, human clinical trials are typically conducted in the following sequential phases, which mayoverlap or be combined:•Phase 1: The drug is initially introduced into healthy human subjects or patients and tested for safety, dose tolerance, absorption, metabolism,distribution and excretion and, if possible, to gain an early indication of its effectiveness.•Phase 2: The drug is administered to a limited patient population to identify possible adverse effects and safety risks, to preliminarily evaluate theefficacy of the product for specific targeted indications and to determine dose tolerance and optimal dosage.•Phase 3: When Phase 2 evaluations demonstrate that a dose range of the product appears to be effective and has an acceptable safety profile, Phase 3“pivotal” trials are undertaken in large patient populations to obtain additional evidence of clinical efficacy and safety in an expanded patientpopulation at multiple, geographically-dispersed clinical trial sites.In some cases, the FDA may condition the approval of the NDA on the sponsor’s agreement to conduct additional pre-clinical and clinical studies tofurther assess the drug’s safety and effectiveness after NDA approval. Such post-approval studies are typically referred to as Post-Marketing or Phase 4studies.The results of product development, pre-clinical studies and clinical trials are submitted to the FDA as part of an NDA. NDAs must also containextensive information relating to the product’s pharmacology, chemistry, manufacturing, and controls (“CMC”) and proposed labeling, among other things.For some drugs, the FDA may determine that a REMS is necessary to9Table of Contentsensure that the benefits of the drug outweigh the risks of the drug, and may require submission of a REMS as a condition of approval. The submission of anNDA is additionally subject to a substantial application user fee, and the manufacturer and/or sponsor under an approved NDA are also subject to annualprogram user fees. The FDA has 60 days from its receipt of an NDA to determine whether the application will be accepted for filing based on the agency’sthreshold determination that it is sufficiently complete to permit substantive review. Once the submission has been accepted for filing, the FDA begins an in-depth substantive review.During the FDA’s review of an NDA the FDA may inspect the facility or facilities where the product is manufactured. The FDA will not approve anapplication unless it determines that the manufacturing processes and facilities are in compliance with cGMP, and if applicable, quality system regulation(“QSR”) requirements (for medical device components), and are adequate to assure consistent production of the product within required specifications.Additionally, the FDA will typically inspect one or more clinical sites to assure compliance with GCP requirements before approving an NDA. The FDA mayalso refer applications for novel drug products or drug products which present difficult questions of safety or efficacy to an advisory committee for review,evaluation and recommendation as to whether the application should be approved and under what conditions. The FDA is not bound by the recommendationof an advisory committee, but it considers such recommendations carefully when making decisions.Once the FDA’s NDA review process is substantially complete, it may issue an approval letter, or it may issue a complete response letter (“CRL”) toindicate that the review cycle for an application is complete and that the application is not ready for approval. CRLs generally outline the deficiencies in thesubmission and may require substantial additional testing or information in order for the FDA to reconsider the application. Even with submission of thisadditional information, the FDA ultimately may decide that the application does not satisfy the regulatory criteria for approval. If and when the deficiencieshave been addressed to the FDA’s satisfaction, the FDA will typically issue an approval letter. An approval letter authorizes commercial marketing of thedrug with specific prescribing information for specific indications.Once issued, the FDA may withdraw product approval if ongoing regulatory requirements are not met or if safety problems are identified after theproduct reaches the market. Drugs may be marketed only for the approved indications and in accordance with the provisions of the approved label, and, evenif the FDA approves a product, it may limit the approved indications for use for the product or impose other conditions, including labeling or distributionrestrictions or a post-market REMS requirement. Further, if there are any modifications to the drug, including changes in indications, labeling, ormanufacturing processes or facilities, the sponsor may be required to submit and obtain FDA approval of a new or supplemental NDA, which may require thedevelopment of additional data or conduct of additional pre-clinical studies and clinical trials.Post-Approval RequirementsOnce an NDA is approved, a product will be subject to pervasive and continuing regulation by the FDA, including, among other things, requirementsrelating to drug/device listing, recordkeeping, periodic reporting, product sampling and distribution, advertising and promotion and reporting of adverseexperiences with the product. There also are extensive U.S. Drug Enforcement Administration, or DEA, regulations applicable to marketed controlledsubstances.Drug manufacturers and other entities involved in the manufacture and distribution of approved drugs are required to register their establishments withthe FDA and state agencies, and are subject to periodic unannounced inspections by the FDA and these state agencies for compliance with cGMP or QSRrequirements. Changes to the manufacturing process are strictly regulated and generally require prior FDA approval before being implemented. FDAregulations also require investigation and correction of any deviations from cGMP or QSR and impose reporting and documentation requirements upon usand any third-party manufacturers that we may decide to use. Accordingly, manufacturers must continue to expend time, money, and effort in the area ofproduction and quality control to maintain cGMP or QSR compliance.Once an approval is granted, the FDA may withdraw the approval if compliance with regulatory requirements and standards is not maintained or ifproblems occur after the product reaches the market, though the FDA must provide an application holder with notice and an opportunity for a hearing inorder to withdraw its approval of an application. Later discovery of previously unknown problems with a product, including adverse events of unanticipatedseverity or frequency, or with manufacturing processes, or failure to comply with regulatory requirements, may result in, among other things:•restrictions on the marketing or manufacturing of the product, complete withdrawal of the product from the market or product recalls;•fines, warning letters or holds on post-approval clinical trials;•refusal of the FDA to approve pending applications or supplements to approved applications, or suspension or revocation of product approvals;10Table of Contents•product seizure or detention, or refusal to permit the import or export of products; or•injunctions or the imposition of civil or criminal penalties.The FDA strictly regulates the marketing, labeling, advertising and promotion of drug and device products that are placed on the market. Whilephysicians may prescribe drugs and devices for off label uses, manufacturers may only promote for the approved indications and in accordance with theprovisions of the approved label. The FDA and other agencies actively enforce the laws and regulations prohibiting the promotion of off label uses, and acompany that is found to have improperly promoted off label uses may be subject to significant liability.In addition, the distribution of prescription pharmaceutical products is subject to the Prescription Drug Marketing Act, or PDMA, and associated FDAregulations, which governs the distribution of drugs and drug samples at the federal level, and sets minimum standards for the registration and regulation ofdrug distributors by the states. Both the PDMA and state laws limit the distribution of prescription pharmaceutical product samples and impose requirementsto ensure accountability in distribution, including a drug pedigree which tracks the distribution of prescription drugs. With the enactment of the DrugQuality and Security Act in November 2013, drug manufacturers will also be subject to requirements for identifying and tracking prescription drugs as theyare distributed in the United States. The requirements of this law will be phased in over a ten-year period, including requirements for unique productidentifiers and provision of product handling information to the FDA.The FDA may require post-approval studies and clinical trials if the FDA finds they are appropriate based on available data, including informationregarding related drugs. The purpose of such studies would be to assess a known serious risk or signals of serious risk related to the drug or to identify anunexpected serious risk when available data indicate the potential for a serious risk. The FDA may also require a labeling change if it becomes aware of newsafety information that it believes should be included in the labeling of a drug. The FDA also has the authority to require a REMS to ensure that the benefitsof a drug outweigh its risks. In determining whether a REMS is necessary, the FDA must consider the size of the population likely to use the drug, theseriousness of the disease or condition to be treated, the expected benefit of the drug, the duration of treatment, the seriousness of known or potential adverseevents, and whether the drug is a new molecular entity. If the FDA determines a REMS is necessary for a new drug, the drug sponsor must submit a proposedREMS as part of its NDA prior to approval. The FDA may also impose a REMS requirement on a drug already on the market if the FDA determines, based onnew safety information, that a REMS is necessary to ensure that the drug’s benefits continue to outweigh its risks. A REMS may be required to includevarious elements, such as a medication guide or patient package insert, a communication plan to educate health care providers of the drug’s risks, limitationson who may prescribe or dispense the drug, requirements that patients enroll in a registry or undergo certain health evaluations and other measures that theFDA deems necessary to assure the safe use of the drug. In addition, the REMS must include a timetable to assess the strategy, at a minimum, at 18 months,three years, and seven years after the strategy’s approval.Concurrently with our clinical development program for ZX008, we plan to develop the appropriate elements of a REMS program to support andmonitor the long-term favorable benefit-risk profile for ZX008. We expect that the FDA will require a REMS for ZX008 including elements to assure safe use,among other requirements, as a condition of approval, consistent with other drugs with known safety issues and that are approved for serious diseases withhigh unmet need. We will be solely responsible for the costs of development of any REMS for ZX008 and will continue to be responsible for all costsassociated with implementation and operation of the REMS if ZX008 is approved.With respect to post-market product advertising and promotion, the FDA imposes a number of complex requirements on entities that advertise andpromote pharmaceuticals, which include, among others, standards for direct-to-consumer advertising, off-label promotion, industry-sponsored scientific andeducational activities, and promotional activities involving the internet and social media. The FDA has very broad enforcement authority under the FFDCA,and failure to abide by these regulations can result in penalties, including the issuance of a warning letter directing entities to correct deviations from FDAstandards, a requirement that future advertising and promotional materials be pre-cleared by the FDA, and state and federal civil and criminal investigationsand prosecutions.Orphan Drug DesignationUnder the Orphan Drug Act, the FDA may grant orphan drug designation to a drug intended to treat a rare disease or condition, which is a disease orcondition that affects fewer than 200,000 individuals in the United States, or if it affects more than 200,000, there is no reasonable expectation that sales ofthe drug in the United States will be sufficient to offset the costs of developing and making the drug available in the United States. Orphan drug designationmust be requested before submitting an NDA. Orphan drug designation does not convey any advantage in or shorten the duration of the regulatory reviewand approval process.11Table of ContentsIf the FDA approves a sponsor’s marketing application for a designated orphan drug for use in the rare disease or condition for which it was designated,the sponsor is eligible for a seven-year period of marketing exclusivity, during which the FDA may not approve another sponsor’s marketing application for adrug with the same active moiety and intended for the same use or indication as the approved orphan drug, except in limited circumstances, such as if asubsequent sponsor demonstrates its product is clinically superior. During a sponsor’s orphan drug exclusivity period, competitors, however, may receiveapproval for drugs with different active moieties for the same indication as the approved orphan drug, or for drugs with the same active moiety as theapproved orphan drug, but for different indications. Orphan drug exclusivity could block the approval of one of our products for seven years if a competitorobtains approval for a drug with the same active moiety intended for the same indication before we do, unless we are able to demonstrate that grounds forwithdrawal of the orphan drug exclusivity exist, or that our product is clinically superior. Further, if a designated orphan drug receives marketing approval foran indication broader than the rare disease or condition for which it received orphan drug designation, it may not be entitled to exclusivity.ZX008 has received orphan drug designation in the United States and the EU for ZX008 in the treatment of Dravet syndrome and LGS. We may seekorphan drug designation for ZX008 for a different indication, or other product candidates, but the FDA may disagree with our analysis of the prevalence ofthe particular disease or condition or other criteria for designation and refuse to grant orphan status. We cannot guarantee that we will obtain orphan drugdesignation or approval for any product candidate, or that we will be able to secure orphan drug exclusivity if we do obtain approval.Section 505(b)(2) New Drug ApplicationsAn applicant may submit an NDA under Section 505(b)(2) of the FFDCA to seek approval for modifications or new uses of products previouslyapproved by the FDA. Section 505(b)(2) was enacted as part of the Drug Price Competition and Patent Term Restoration Act of 1984, also known as theHatch-Waxman Amendments, and permits the filing of an NDA where at least some of the information required for approval comes from studies notconducted by or for the applicant and for which the applicant has not obtained a right of reference. The applicant may rely upon published literature and theFDA’s previous findings of safety and effectiveness for an approved product based on the prior pre-clinical or clinical trials conducted for the approvedproduct. The FDA may also require companies to perform new studies or measurements to support the change from the approved product. The FDA may thenapprove the new product candidate for all or some of the label indications for which the referenced product has been approved, as well as for any newindication sought by the Section 505(b)(2) applicant.To the extent that a Section 505(b)(2) NDA relies on studies conducted for a previously approved drug product, the applicant is required to certify tothe FDA concerning any patents listed for the approved product in the FDA’s current list of “Approved Drug Products with Therapeutic EquivalenceEvaluations,” known as the Orange Book. Specifically, the applicant must certify for each listed patent that (1) the required patent information has not beenfiled; (2) the listed patent has expired; (3) the listed patent has not expired, but will expire on a particular date and approval is sought after patent expiration;or (4) the listed patent is invalid, unenforceable or will not be infringed by the new product. A certification that the new product will not infringe the alreadyapproved product’s listed patent or that such patent is invalid is known as a Paragraph IV certification. If the applicant does not challenge the listed patentsthrough a Paragraph IV certification, the Section 505(b)(2) NDA application will not be approved until all the listed patents claiming the referenced producthave expired. The Section 505(b)(2) NDA application also will not be accepted or approved until any non-patent exclusivity, such as exclusivity forobtaining approval of a New Chemical Entity, listed in the Orange Book for the referenced product, has expired.If the 505(b)(2) NDA applicant has provided a Paragraph IV certification to the FDA, the applicant must also send notice of the Paragraph IVcertification to the referenced NDA and patent holders once the 505(b)(2) NDA has been accepted for filing by the FDA. The NDA and patent holders maythen initiate a legal challenge based on the Paragraph IV certification. Under the FFDCA, if a patent infringement lawsuit is filed against the 505(b)(2) NDAapplicant within 45 days of receipt of the Paragraph IV certification notice, an automatic stay of approval is imposed, which prevents the FDA fromapproving the Section 505(b)(2) NDA for 30 months, or until a court decision or settlement finding that the patent is invalid, unenforceable or not infringed,whichever is earlier. The court also has the ability to shorten or lengthen the 30 month stay if either party is found not to be reasonably cooperating inexpediting the litigation. Thus, the 505(b)(2) NDA applicant may invest a significant amount of time and expense in the development of its product only tobe subject to significant delay and patent litigation before its product may be commercialized.The 505(b)(2) NDA applicant may be eligible for its own regulatory exclusivity period, such as three-year new product exclusivity. The first approved505(b)(2) applicant for a particular condition of approval, or change to a marketed product, such as a new extended-release formulation for a previouslyapproved product, may be granted three-year Hatch-Waxman exclusivity if one or more clinical trials, other than bioavailability or bioequivalence studies,was essential to the approval of the application and was conducted/sponsored by the applicant. Should this occur, the FDA is precluded from makingeffective any other application for the same condition of use or for a change to the drug product that was granted exclusivity until after12Table of Contentsthat three-year exclusivity period has expired. Additional exclusivities may also apply, such as an added six-month pediatric exclusivity period based onstudies conducted in pediatric patients under a written request from the FDA.Additionally, the 505(b)(2) NDA applicant may list its own relevant patents in the Orange Book, and if it does, it can initiate patent infringementlitigation against subsequent applicants that challenge such patents, which could result in a 30-month stay delaying those applicants.DEA RegulationThe Controlled Substances Act of 1970 (“CSA”) establishes registration, security, recordkeeping, reporting, storage, distribution and otherrequirements administered by the DEA. The DEA is concerned with the control of handlers of controlled substances, and with the equipment and rawmaterials used in their manufacture and packaging, in order to prevent loss and diversion into illicit channels of commerce.The DEA regulates controlled substances as Schedule I, II, III, IV or V substances. Schedule I substances by definition have no established medicinaluse, and may not be marketed or sold in the United States. A pharmaceutical product may be listed as Schedule II, III, IV or V, with Schedule II substancesconsidered to present the highest risk of abuse and Schedule V substances the lowest relative risk of abuse among such substances.Fenfluramine, the active ingredient in ZX008, is currently regulated as a Schedule IV drug in the United States. Substances in Schedule IV areconsidered to have a low potential for abuse relative to substances in Schedule III. A prescription for controlled substances in Schedules III, IV, and V issuedby a practitioner, may be communicated either orally, in writing, or by facsimile to the pharmacist, and may be refilled if so authorized on the prescription orby call-in. Many commonly prescribed sleep aids (e.g., Ambien®, Sonata®), most benzodiazepines (e.g., Ativan®, Valium®, Versed®, Diastat®, Onfi®) andsome weight loss drugs (e.g., Belviq®, Qsymia®) are also regulated as Schedule IV drugs.Annual registration is required for any facility that manufactures, distributes, dispenses, imports or exports any controlled substance. The registration isspecific to the particular location, activity and controlled substance schedule. For example, separate registrations are needed for import and manufacturing,and each registration will specify which schedules of controlled substances are authorized.The DEA typically inspects a facility to review its security measures prior to issuing a registration. Security requirements vary by controlled substanceschedule, with the most stringent requirements applying to Schedule I and Schedule II substances. Required security measures include background checks onemployees and physical control of inventory through measures such as cages, surveillance cameras and inventory reconciliations. Records must bemaintained for the handling of all controlled substances, and periodic reports made to the DEA. Reports must also be made for thefts or losses of anycontrolled substance, and authorization must be obtained to destroy any controlled substance. In addition, special authorization and notificationrequirements apply to imports and exports.To meet its responsibilities, the DEA conducts periodic inspections of registered establishments that handle controlled substances. Failure to maintaincompliance with applicable requirements, particularly as manifested in loss or diversion, can result in enforcement action that could have a material adverseeffect on our business, results of operations and financial condition. The DEA may seek civil penalties, refuse to renew necessary registrations, or initiateproceedings to revoke those registrations. In certain circumstances, violations could eventuate in criminal proceedings.Individual states also regulate controlled substances, and we and our contract manufacturers will be subject to state regulation on distribution of theseproducts.International RegulationIn addition to regulations in the United States, we are subject to a variety of foreign regulations regarding safety and efficacy and governing, amongother things, clinical trials and commercial sales and distribution of our products. Whether or not we obtain FDA approval for a product, we must obtain thenecessary approvals by the comparable and respective regulatory authorities of foreign countries before we can commence clinical trials or marketing of theproduct in those countries. The approval process varies from country to country and can involve additional product testing and additional review periods,and the time may be longer or shorter than that required to obtain FDA approval and, if applicable, DEA classification. The requirements governing, amongother things, the conduct of clinical trials, product licensing, pricing and reimbursement vary greatly from country to country. Regulatory approval in onecountry does not ensure regulatory approval in another, but a failure or delay in obtaining regulatory approval in one country may negatively impact theregulatory process in others.13Table of ContentsUnder EU regulatory systems, marketing authorizations may be submitted either under a centralized or decentralized procedure. The centralizedprocedure provides for the grant of a single marketing authorization that is valid for all EU member states. The decentralized procedure provides for mutualrecognition of national approval decisions. Under this procedure, the holder of a national marketing authorization may submit an application to theremaining member states. Within 90 days of receiving the applications and assessment report, each member state must decide whether to recognize approval.In addition to regulations in Europe and the United States, we are subject to a variety of other foreign regulations governing, among other things, theconduct of clinical trials, pricing and reimbursement and commercial distribution of our products. If we fail to comply with applicable foreign regulatoryrequirements, we may be subject to fines, suspension or withdrawal of regulatory approvals, product recalls, seizure of products, operating restrictions andcriminal prosecution.Healthcare Fraud and Abuse LawsWe are subject to various federal, state and local laws targeting fraud and abuse in the healthcare industry. These laws are applicable to manufacturersof products regulated by the FDA, such as us, and hospitals, physicians and other potential purchasers of such products.In particular, the federal Anti-Kickback Statute prohibits persons from knowingly and willfully soliciting, receiving, offering or providingremuneration, directly or indirectly, to induce either the referral of an individual, or the furnishing, recommending, or arranging for a good or service, forwhich payment may be made under a federal healthcare program such as the TRICARE, Medicare and Medicaid programs. The term “remuneration” is notdefined in the federal Anti-Kickback Statute and has been broadly interpreted to include anything of value, including for example, gifts, discounts, thefurnishing of supplies or equipment, credit arrangements, payments of cash, waivers of payments, ownership interests and providing anything at less than itsfair market value. Moreover, the lack of uniform court interpretation of the Anti-Kickback Statute makes compliance with the law difficult. In addition, aperson or entity does not need to have actual knowledge of the statute or specific intent to violate it in order to have committed a violation. In addition, thegovernment may assert that a claim including items or services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulentclaim for purposes of the civil False Claims Act (discussed below) or the civil monetary penalties statute, which imposes fines against any person who isdetermined to have presented or caused to be presented claims to a federal health care program that the person knows or should know is for an item or servicethat was not provided as claimed or is false or fraudulent.Additionally, many states have adopted laws similar to the federal Anti-Kickback Statute. Some of these state prohibitions apply to referral of patientsfor healthcare items or services reimbursed by any third-party payor, not only the Medicare and Medicaid programs in at least some cases, and do not containsafe harbors or statutory exceptions. Government officials have focused their enforcement efforts on marketing of healthcare services and products, amongother activities, and have brought cases against numerous pharmaceutical and medical device companies, and certain sales and marketing personnel forallegedly offering unlawful inducements to potential or existing customers in an attempt to procure their business or reward past purchases orrecommendations.Another development affecting the healthcare industry is the increased use of the federal civil False Claims Act and, in particular, actions broughtpursuant to the False Claims Act’s “whistleblower” or “qui tam” provisions. The civil False Claims Act imposes liability on any person or entity who, amongother things, knowingly presents, or causes to be presented, a false or fraudulent claim for payment by a federal healthcare program. The qui tam provisions ofthe False Claims Act allow a private individual to bring civil actions on behalf of the federal government alleging that the defendant has submitted a falseclaim to the federal government, and to share in any monetary recovery. In recent years, the number of suits brought by private individuals has increaseddramatically. When an entity is determined to have violated the False Claims Act, it may be required to pay up to three times the actual damages sustained bythe government, plus civil penalties of $11,181 to $22,363 for each separate false claim. The False Claims Act has been used to assert liability on the basis ofinadequate care, kickbacks and other improper referrals, improperly reported government pricing metrics such as Best Price or Average Manufacturer Priceand improper promotion of off-label uses (i.e., uses not expressly approved by FDA in a drug’s label). In addition, various states have enacted false claim lawsanalogous to the False Claims Act. Many of these state laws apply where a claim is submitted to any third-party payor and not merely a federal healthcareprogram.The Health Insurance Portability and Accountability Act of 1996, or HIPAA, created several new federal crimes, including health care fraud, and falsestatements relating to health care matters. The health care fraud statute prohibits knowingly and willfully executing a scheme to defraud any health carebenefit program, including private third-party payors. The false statements statute prohibits knowingly and willfully falsifying, concealing or covering up amaterial fact or making any materially false, fictitious or fraudulent statement in connection with the delivery of or payment for health care benefits, items orservices. Similar to the federal Anti-Kickback Statute, a person or entity does not need to have actual knowledge of the statute or specific intent to violate itin order to have committed a violation.14Table of ContentsThe Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act, or collectively, the PPACA, alsoimposes new reporting and disclosure requirements on drug manufacturers for any “transfer of value” made or distributed to prescribers and other healthcareproviders, and any ownership or investment interests held by physicians and their immediate family members during the preceding calendar year. Failure tosubmit required information may result in civil monetary penalties of up to an aggregate of $165,786 per year (and up to an aggregate of $1.1 million peryear for “knowing failures”), for all payments, transfers of value or ownership or investment interests not reported in an annual submission. Manufacturers arerequired to report such data to the government by the 90th day of each calendar year.Under California law, pharmaceutical companies must adopt a comprehensive compliance program that is in accordance with both the Office ofInspector General Compliance Program Guidance for Pharmaceutical Manufacturers, or OIG Guidance, and the Pharmaceutical Research and Manufacturersof America Code on Interactions with Healthcare Professionals, or the PhRMA Code. The PhRMA Code seeks to promote transparency in relationshipsbetween health care professionals and the pharmaceutical industry and to ensure that pharmaceutical marketing activities comport with the highest ethicalstandards. The PhRMA Code contains strict limitations on certain interactions between health care professionals and the pharmaceutical industry relating togifts, meals, entertainment and speaker programs, among others. Also, certain states have imposed restrictions on the types of interactions that pharmaceuticalcompanies or their agents (e.g., sales representatives) may have with health care professionals, including bans or strict limitations on the provision of meals,entertainment, hospitality, travel and lodging expenses, and other financial support, including funding for continuing medical education activities.Healthcare Privacy and Security LawsWe may be subject to, or our marketing activities may be limited by, HIPAA, and its implementing regulations, including the final omnibus rulepublished on January 25, 2013, which established uniform standards for certain “covered entities” (healthcare providers, health plans and healthcareclearinghouses) governing the conduct of certain electronic healthcare transactions and protecting the security and privacy of protected health information.The American Recovery and Reinvestment Act of 2009, commonly referred to as the economic stimulus package, included sweeping expansion of HIPAA’sprivacy and security standards called the Health Information Technology for Economic and Clinical Health Act, or HITECH, which became effective onFebruary 17, 2010. Among other things, the new law makes HIPAA’s privacy and security standards directly applicable to “business associates” —independent contractors or agents of covered entities that receive or obtain protected health information in connection with providing a service on behalf ofa covered entity. HITECH also increased the civil and criminal penalties that may be imposed against covered entities, business associates and possibly otherpersons, and gave state attorneys general new authority to file civil actions for damages or injunctions in federal courts to enforce the federal HIPAA laws andseek attorney’s fees and costs associated with pursuing federal civil actions.Third-Party Payor Coverage and ReimbursementThe commercial success of our product candidates, if and when commercialized, will depend, in part, upon the availability of coverage andreimbursement from third-party payors at the federal, state and private levels. Third-party payors include governmental programs such as Medicare orMedicaid, private insurance plans and managed care plans. These third-party payors may deny coverage or reimbursement for a product or therapy in wholeor in part if they determine that the product or therapy was not medically appropriate or necessary. Also, third-party payors have attempted to control costs bylimiting coverage through the use of formularies and other cost-containment mechanisms and the amount of reimbursement for particular procedures or drugtreatments.Changes in third-party payor coverage and reimbursement rules can impact our business. For example, the PPACA changes include increased rebates amanufacturer must pay to the Medicaid program, addressed a new methodology by which rebates owed by manufacturers under the Medicaid Drug RebateProgram are calculated for drugs that are inhaled, infused, instilled, implanted or injected, and established a new Medicare Part D coverage gap discountprogram, in which manufacturers must provide 50% point-of-sale discounts on products covered under Part D. Further, the law imposes a significant annual,nondeductible fee on companies that manufacture or import branded prescription drug products. Substantial new provisions affecting compliance have alsobeen enacted, which may require us to modify our business practices with health care practitioners. The Bipartisan Budget Act of 2018 increased the point-of-sale discount manufacturers must agree to offer under the Medicare part D coverage gap discount program from 50% to 70%, starting in 2019. PPACA andother healthcare reform measures continue to put pressure on pharmaceutical pricing, as well as increase our regulatory burdens and operating costs.Other legislative changes have also been proposed and adopted in the United States since the PPACA was enacted. For example, in August 2011, theBudget Control Act of 2011, among other things included aggregate reductions to Medicare payments to providers of 2% per fiscal year, which went intoeffect on April 1, 2013, and, due to subsequent legislative amendments to the statute, will remain in effect through 2025 unless additional Congressionalaction is taken. In January 2013,15Table of Contentsthe American Taxpayer Relief Act of 2012, among other things, further reduced Medicare payments to several providers, including hospitals, imaging centersand cancer treatment centers, and increased the statute of limitations period for the government to recover overpayments to providers from three to five years.Recently, there has been heightened governmental scrutiny over the manner in which drug manufacturers set prices for their marketed products, whichhas resulted in several Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing, review therelationship between pricing and manufacturer patient programs, and reform government program reimbursement methodologies for drug products.Individual states have also become increasingly active in passing legislation and implementing regulations designed to control pharmaceutical productpricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access, and to encourage importation from othercountries and bulk purchasing. These new laws may result in additional reductions in Medicare and other health care funding, which could have a materialadverse effect on our customers and accordingly, our financial operations.In international markets, reimbursement and healthcare payment systems vary significantly by country, and many countries have instituted priceceilings on specific products and therapies. There can be no assurance that our products will be considered medically reasonable and necessary for a specificindication, that our products will be considered cost-effective by third-party payors, that an adequate level of reimbursement will be established even ifcoverage is available or that the third-party payors’ reimbursement policies will not adversely affect our ability to sell our products profitably.Manufacturing RequirementsWe and our third-party manufacturers must comply with applicable FDA regulations relating to FDA’s cGMP regulations and, if applicable, QSRrequirements. The cGMP regulations include requirements relating to, among other things, organization of personnel, buildings and facilities, equipment,control of components and drug product containers and closures, production and process controls, packaging and labeling controls, holding and distribution,laboratory controls, records and reports, and returned or salvaged products. The manufacturing facilities for our products must meet cGMP requirements to thesatisfaction of the FDA pursuant to a pre-approval inspection before we can use them to manufacture our products. We and our third-party manufacturers arealso subject to periodic unannounced inspections of facilities by the FDA and other authorities, including procedures and operations used in the testing andmanufacture of our products to assess our compliance with applicable regulations. Failure to comply with statutory and regulatory requirements subjects amanufacturer to possible legal or regulatory action, including, among other things, warning letters, the seizure or recall of products, injunctions, consentdecrees placing significant restrictions on or suspending manufacturing operations and civil and criminal penalties.Other Regulatory RequirementsWe are also subject to various laws and regulations regarding laboratory practices, the experimental use of animals, and the use and disposal ofhazardous or potentially hazardous substances in connection with our research. In each of these areas, as above, the FDA has broad regulatory andenforcement powers, including, among other things, the ability to levy fines and civil penalties, suspend or delay issuance of approvals, seize or recallproducts, and withdraw approvals, any one or more of which could have a material adverse effect on us.EmployeesAs of December 31, 2017, we employed 68 full-time employees. Of the full-time employees, 43 were engaged in product development, qualityassurance and clinical and regulatory activities, 6 were engaged in sales and marketing and 19 were engaged in general and administrative activities(including business and corporate development).None of our employees are represented by a labor union, and we consider our employee relations to be good. We currently utilize two employerservices companies to provide human resource services. These service companies are the employer of record for payroll, benefits, employee relations andother employment-related administration.Research and DevelopmentWe invested $67.4 million, $41.8 million and $27.9 million in research and development in 2017, 2016 and 2015, respectively.About ZogenixWe were formed as a Delaware corporation on May 11, 2006 as SJ2 Therapeutics, Inc. We changed our name to Zogenix, Inc. on August 28, 2006. Ourprincipal executive offices are located at 5858 Horton Street, Suite 455, Emeryville,16Table of ContentsCalifornia 94608, and our telephone number is 1-866-ZOGENIX (1-866-964-3649). We conduct our research and development activities and general andadministrative functions primarily from our Emeryville, California location.We formed a wholly-owned subsidiary, Zogenix Europe Limited, in June 2010, a company organized under the laws of England and Wales and whichis located in the United Kingdom, and whose principal operations were to support the manufacture of the DosePro technology. Zogenix International Limitedis a wholly-owned subsidiary of Zogenix Europe Limited which was acquired in October 2014.Financial Information about SegmentsWe manage our business as one segment which includes all activities related to the development and commercialization of pharmaceutical products.For financial information related to our one segment, see “Management's Discussion and Analysis of Financial Condition and Results of Operations” and ourconsolidated financial statements and related notes included in this Annual Report on 10-K.Available InformationWe file our annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K electronically with the Securities andExchange Commission, or SEC, pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended. We make copies of these reportsavailable on our website at www.zogenix.com, free of charge, as soon as reasonably practicable after we electronically file such material with, or furnish it to,the SEC. The public may read or copy any materials we file with the SEC at the SEC’s Public Reference Room at 100 F Street NE, Washington, D.C. 20549.The public may obtain information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. The SEC maintains an Internetsite that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC. The address of thatsite is http://www.sec.gov. The information in or accessible through the SEC and our website are not incorporated into, and are not considered part of, thisfiling. Further, our references to the URLs for these websites are intended to be inactive textual references only.17Table of ContentsItem 1A. Risk FactorsWe operate in a dynamic and rapidly changing environment that involves numerous risks and uncertainties. Certain factors may have a materialadverse effect on our business prospects, financial condition and results of operations, and you should carefully consider them. Accordingly, in evaluatingour business, we encourage you to consider the following discussion of risk factors, in its entirety, in addition to other information contained in this AnnualReport on Form 10-K and our other public filings with the Securities and Exchange Commission, or SEC. Other events that we do not currently anticipateor that we currently deem immaterial may also affect our business, prospects, financial condition and results of operations.Risks Related to Our Business and IndustryOur success depends substantially on our only product candidate in development, ZX008. We cannot be certain that ZX008 or our product candidates willreceive regulatory approval or be successfully commercialized.We have only one product candidate in clinical development, and our business depends substantially on its successful development andcommercialization. We currently have no drug products approved for sale, and we may not be able to develop marketable drug products in the future.Following the termination of the development and license agreement with Durect Corporation in August 2017, our sole product candidate in clinicaldevelopment is ZX008. ZX008 and our product candidates will require additional clinical and pre-clinical development, regulatory review and approval inmultiple jurisdictions, substantial investment, access to sufficient commercial manufacturing capacity and significant marketing efforts before we cangenerate any revenues from product sales. The research, testing, manufacturing, labeling, approval, sale, marketing, distribution and promotion of drugproducts are subject to extensive regulation by the U.S. Food and Drug Administration, or FDA, and other regulatory authorities in the United States andother countries, whose regulations differ from country to country.We are not permitted to market our product candidates in the United States until we receive approval of a new drug application, or NDA, from the FDA,or in any foreign countries until we receive the requisite approval from the regulatory authorities of such countries, and we may never receive such regulatoryapprovals. Obtaining regulatory approval for a product candidate is a lengthy, expensive and uncertain process, and may not be successful. Any failure toobtain regulatory approval of ZX008 or our product candidates, or failure to obtain such approval for all of the indications and labeling claims we deemdesirable, would limit our ability to generate future revenues, would potentially harm the development prospects of ZX008 and would have a material andadverse impact on our business.Even if we successfully obtain regulatory approvals to market our product candidates, our revenues will be dependent, in part, on our ability tocommercialize such products as well as the size of the markets in the territories for which we gain regulatory approval. If the markets for our productcandidates are not as significant as we estimate, our business and prospects will be harmed.Our clinical trials may fail to demonstrate acceptable levels of safety and efficacy for ZX008 or our product candidates, which could prevent orsignificantly delay their regulatory approval.ZX008 and our product candidates are prone to the risks of failure inherent in drug development. Before obtaining U.S. regulatory approval for thecommercial sale of ZX008 or our product candidates, we must gather substantial evidence from well-controlled clinical trials that demonstrate to thesatisfaction of the FDA that the product candidate in question is safe and effective, and similar regulatory approvals would be necessary to commercialize ourproduct candidates in other countries. Failure can occur at any stage of our clinical trials, and we could encounter problems that cause us to abandon or repeatclinical trials.A number of companies in the biotechnology and pharmaceutical industries have suffered significant setbacks in advanced clinical trials, even afterpromising results in earlier trials. If ZX008 is not shown to be safe and effective in clinical trials, the programs could be delayed or terminated, which couldhave a material adverse effect on our business, results of operations, financial condition and prospects.The results of previous clinical trials may not be predictive of future results, and the results of our current and planned clinical trials may not satisfy therequirements of the FDA or non‑U.S. regulatory authorities.The results from the prior clinical trials of ZX008 discussed elsewhere in this report may not necessarily be predictive of the results of future clinicaltrials or preclinical studies. Even if we are able to complete our planned clinical trials of ZX008 according to our current development timeline, the resultsfrom our prior clinical trials of ZX008 may not be replicated in these future trials. Clinical data are often susceptible to varying interpretations and analyses,and many companies that believed their product candidates performed satisfactorily in prior clinical trials nonetheless have failed to obtain FDA approval. Ifwe fail to produce positive results in our clinical trials of ZX008, the development timeline and regulatory approval and commercialization prospects forZX008 and our business and financial prospects, would be adversely affected.18Table of ContentsFurther, ZX008 may not be approved even if it achieves its primary endpoint in our ongoing Phase 3 clinical trials. The FDA or non‑U.S. regulatoryauthorities may disagree with our trial design and our interpretation of data from preclinical studies and clinical trials. In addition, any of these regulatoryauthorities may change its requirements for the approval of a product candidate even after reviewing and providing comments or advice on a protocol for apivotal clinical trial that, if successful, would potentially form the basis for an application for approval by the FDA or another regulatory authority.Furthermore, any of these regulatory authorities may also approve our product candidates for fewer or more limited indications than we request or may grantapproval contingent on the performance of costly post‑marketing clinical trials.Top-line data may not accurately reflect the complete results of a particular study or trial.We may publicly disclose top-line or interim data from time to time, which is based on a preliminary analysis of then-available efficacy and safety datasuch as the top-line results we reported from Study 1, and the results and related findings and conclusions are subject to change following a morecomprehensive review of the data related to the particular study or trial. We also make assumptions, estimations, calculations and conclusions as part of ouranalyses of data, and we may not have received or had the opportunity to fully and carefully evaluate all data. As a result, the top-line results that we reportmay differ from future results of the same studies, or different conclusions or considerations may qualify such results, once additional data have been receivedand fully evaluated. Top-line data also remain subject to audit and verification procedures that may result in the final data being materially different from thepreliminary data we previously published. As a result, top-line data should be viewed with caution until the final data are available. Further, others, includingregulatory agencies, may not accept or agree with our assumptions, estimations, calculations, conclusions or analyses or may interpret or weigh theimportance of data differently, which could impact the value of the particular program, the approvability or commercialization of the particular drugcandidate or drug and our company in general. In addition, the information we may publicly disclose regarding a particular study or clinical trial is based onwhat is typically extensive information, and you or others may not agree with what we determine is the material or otherwise appropriate information toinclude in our disclosure, and any information we determine not to disclose may ultimately be deemed significant with respect to future decisions,conclusions, views, activities or otherwise regarding a particular drug, drug candidate or our business. If the top-line data that we report differ from actualresults, or if others, including regulatory authorities, disagree with the conclusions reached, our ability to obtain approval for, and commercialize, our productcandidates may be harmed, which could harm our business, operating results, prospects or financial condition.Delays in the commencement or completion of clinical testing for ZX008 or pre-clinical or clinical testing for our product candidates could result inincreased costs to us and delay or limit our ability to pursue regulatory approval for, or generate revenues from, such product candidates.Clinical trials are very expensive, time consuming and difficult to design and implement. Delays in the commencement or completion of clinicaltesting for ZX008 or pre-clinical or clinical testing for our product candidates could significantly affect our product development costs and business plan.Our Phase 3 program for ZX008 includes three randomized, double-blind placebo-controlled clinical trials of ZX008 as adjunctive therapy for patientswith uncontrolled seizures who have Dravet syndrome and one randomized, double-blind placebo-controlled clinical trial of ZX008 for patients withLennox-Gastaut Syndrome, or LGS. In September 2017, we announced positive top line data from two identical clinical trials, Study 1501 in the U.S. andCanada and Study 1502 in Europe and Australia, which we collectively refer to as Study 1. Study 1 evaluated two dose levels of ZX008 (0.2 mg/kg/day and0.8 mg/kg/day, up to a maximum daily dose of 30 mg) and met its primary efficacy endpoint of reducing convulsive seizures experienced by patients aftertreatment of ZX008 compared to treatment with a placebo. In December 2017, we reported additional data from Study 1. Study 1504 is evaluating a singledose a ZX008 (0.5 mg/kg/day, up to a maximum daily dose of 20 mg, which has been shown to be equivalent to 0.8mg/kg/day in patients not takingstiripentol), in patients taking stiripentol, valproate and/or clobazam. Study 1504 is a multi-national study commenced in the third quarter 2016 and is beingconducted in western Europe and North America. We expect to report top-line results from the trial in the second quarter of 2018. Notwithstanding theaforementioned plans, we may not be able to identify and enroll sufficient number of study participants and interpret results on these time frames, andconsequently the completion of our ongoing Phase 3 clinical trials may be delayed.In November 2017, we enrolled our first patient in our Phase 3 clinical trial of ZX008 as an adjunctive treatment of seizures associated with LGS,Study 1601. Study 1601 is divided in two parts. Part 1 is a double-blind, placebo-controlled investigation to assess the safety, tolerability and efficacy ofZX008, low-dose fenfluramine, when added to a patient’s current anti-epileptic therapy. The trial will include two dose levels of ZX008 (0.2 mg/kg/day and0.8 mg/kg/day, up to a maximum daily dose of 30 mg), as well as placebo. After establishing baseline seizure frequency for 4 weeks, randomized patients willbe titrated to their dose over a 2-week titration period, followed by a 12-week fixed dose maintenance period. We are targeting a total of 225 patients (75 pertreatment arm) in the trial. The primary endpoint of the clinical trial is change in the number of seizures that result in drops between baseline and thecombined titration and maintenance periods at the 0.8 mg/kg/day dose.19Table of ContentsPart 2 of Study 1601 will be a 12-month open-label extension to evaluate the long-term safety, tolerability and effectiveness of ZX008.The completion of clinical trials can be delayed for a number of reasons, including delays related to:•obtaining regulatory authorization to commence a clinical trial;•reaching agreement on acceptable terms with clinical research organizations, or CROs, clinical investigators and trial sites;•manufacturing or obtaining sufficient quantities of a product candidate and placebo for use in clinical trials;•obtaining institutional review board, or IRB, approval to initiate and conduct a clinical trial at a prospective site;•identifying, recruiting and training suitable clinical investigators;•identifying, recruiting and enrolling subjects to participate in clinical trials for a variety of reasons, including competition from other clinical trialprograms for the treatment of similar indications;•retaining patients who have initiated a clinical trial but may be prone to withdraw due to side effects from the therapy, lack of efficacy, personalissues, or for any other reason they choose, or who are lost to further follow-up;•uncertainty regarding proper dosing; and•scheduling conflicts with participating clinicians and clinical institutions.In addition, if a significant number of patients fail to stay enrolled in any of our current or future clinical trials of ZX008 and such failure is notadequately accounted for in our trial design and enrollment assumptions, our clinical development program could be delayed. Clinical trials may also bedelayed or repeated as a result of ambiguous or negative interim results or unforeseen complications in testing. In addition, a clinical trial may be suspendedor terminated by us, the FDA, the IRB overseeing the clinical trial at issue, any of our clinical trial sites with respect to that site, or other regulatory authoritiesdue to a number of factors, including:•inability to design appropriate clinical trial protocols;•inability by us, our employees, our CROs or their employees to conduct the clinical trial in accordance with all applicable FDA, drug enforcementadministration, or DEA, or other regulatory requirements or our clinical protocols;•inspection of the clinical trial operations or trial sites by the FDA or other regulatory authorities resulting in the imposition of a clinical hold;•discovery of serious or unexpected toxicities or side effects experienced by study participants or other unforeseen safety issues;•lack of adequate funding to continue the clinical trial, including the incurrence of unforeseen costs due to enrollment delays, requirements toconduct additional trials and studies and increased expenses associated with the services of our CROs and other third parties;•lack of effectiveness of any product candidate during clinical trials;•slower than expected rates of subject recruitment and enrollment rates in clinical trials;•inability of our CROs or other third-party contractors to comply with all contractual requirements or to perform their services in a timely oracceptable manner;•inability or unwillingness of medical investigators to follow our clinical protocols; and•unfavorable results from on-going clinical trials and pre-clinical studies.Additionally, changes in applicable regulatory requirements and guidance may occur and we may need to amend clinical trial protocols to reflect thesechanges. Amendments may require us to resubmit our clinical trial protocols to the FDA and IRBs for reexamination, which may impact the costs, timing orsuccessful completion of a clinical trial. If we experience delays in the completion of, or if we terminate, any of our clinical trials, the commercial prospectsfor ZX008 and our product candidates may be harmed, which may have a material adverse effect on our business, results of operations, financial conditionand prospects.Fast Track designation for ZX008 may not lead to a faster development or review process.We have been granted a Fast Track designation for ZX008 in the United States for the treatment of Dravet syndrome. The Fast Track program is intendedto expedite or facilitate the process for reviewing new drug candidates that meet certain criteria. Specifically, new drugs are eligible for Fast Trackdesignation if they are intended, alone or in combination with one or more20Table of Contentsdrugs, to treat a serious or life-threatening disease or condition and demonstrate the potential to address unmet medical needs for the disease or condition.Fast Track designation applies to the combination of the drug candidate and the specific indication for which it is being studied. With a Fast Track drugcandidate, the FDA may consider for review sections of the NDA on a rolling basis before the complete application is submitted, if the sponsor provides aschedule for the submission of the sections of the NDA, the FDA agrees to accept sections of the NDA and determines that the schedule is acceptable and thesponsor pays any required user fees upon submission of the first section of the NDA.Obtaining a Fast Track designation does not change the standards for product approval, but may expedite the development or approval process. Eventhough the FDA has granted such designation for ZX008, it may not actually result in faster clinical development or regulatory review or approval.Furthermore, such a designation does not increase the likelihood that ZX008 will receive marketing approval in the United States.We have limited sales and marketing resources, and we may not be able to effectively market and sell our products.We do not currently have all the necessary components of an organization for sales, marketing and distribution of pharmaceutical products, andtherefore we must build this organization or make arrangements with third parties to perform these functions in order to commercialize any products that wesuccessfully develop and for which we obtain regulatory approvals. We will have to compete with other pharmaceutical and biotechnology companies torecruit, hire, train and retain sales and marketing personnel. We will also face competition in our search for collaborators and potential co-promoters, if wechoose such an option. To the extent we may rely on third parties to co-promote or otherwise commercialize any product candidates in one or more regionsthat may receive regulatory approval, we are likely to receive less revenue than if we commercialized these products ourselves. Further, by entering intostrategic partnerships or similar arrangements, we may rely in part on such third parties for financial and commercialization resources. Even if we are able toidentify suitable partners to assist in the commercialization of our product candidates, they may be unable to devote the resources necessary to realize the fullcommercial potential of our products.Further, we may lack the financial and managerial resources to establish a sales and marketing organization to adequately promote and commercializeany product candidates that may be approved. The establishment of a sales force will result in an increase in our expenses, which could be significant beforewe generate revenues from any newly approved product candidate. Even though we may be successful in establishing future partnership arrangements, suchsales force and marketing teams may not be successful in commercializing our products, which would adversely affect our ability to generate revenue for suchproducts, and could have a material adverse effect on our business, results of operations, financial condition and prospects.We face intense competition, and if our competitors market and/or develop treatments for Dravet syndrome or psychiatric disorders that are marketedmore effectively, approved more quickly than our product candidates or demonstrated to be safer or more effective than our products, our commercialopportunities will be reduced or eliminated.The pharmaceutical industry is characterized by rapidly advancing technologies, intense competition and a strong emphasis on proprietarytherapeutics. We face competition from a number of sources, some of which may target the same indications as our product candidates, including largepharmaceutical companies, smaller pharmaceutical companies, biotechnology companies, academic institutions, government agencies and private andpublic research institutions, many of which have greater financial resources, sales and marketing capabilities, including larger, well-established sales forces,manufacturing capabilities, experience in obtaining regulatory approvals for product candidates and other resources than we do.If approved for the chronic treatment of Dravet syndrome, ZX008 may compete against other products and product candidates. Stiripentol is approvedin Europe, Canada, Australia and Japan for the treatment of Dravet syndrome when used in conjunction with valproate and/or clobazam. In Europe,stiripentol was granted an orphan drug designation for the treatment of Dravet syndrome in 2001. In the United States, stiripentol is not FDA approved andcan only be obtained via the FDA’s Personal Importation Policy, or PIP, or under an Expanded Access IND. The FDA’s PIP is intended to make available,through the exercise of enforcement discretion, unapproved drugs used to treat serious medical conditions for which no equivalent treatment exists in theUnited States, and unapproved drugs used to continue treatment begun in a foreign country. All new patients obtaining stiripentol must have a patientspecific IND application submitted to the FDA by the prescribing physician, who is most often an academic pediatric neurologist. The manufacturer ofstiripentol, Biocodex, may in the future seek and receive FDA approval for stiripentol for the treatment of Dravet syndrome. Epidiolex®, a cannabinoid drug,is in clinical development for Dravet syndrome and LGS by GW Pharmaceuticals. In March 2016, GW Pharmaceuticals announced positive results from itsfirst Phase 3 clinical trial for Epidiolex for the treatment of Dravet syndrome, and in June and September 2016 announced positive results from its two Phase3 clinical trials for Epidiolex for the treatment of LGS, with Epidiolex achieving its primary study endpoints in all three trials. GW Pharmaceuticals iscurrently conducting an additional Phase 3 study in Dravet syndrome and in December 2017 announced data from the second Phase 3 study in Dravetsyndrome is expected in the second half of 2018. Also in December 2017, GW Pharmaceuticals announced FDA acceptance of its NDA filing for Epidiolex inthe treatment of LGS and Dravet syndrome and that an MAA for Epidiolex in both indications had been filed in Europe. Insys Therapeutics, or Insys, isdeveloping a synthetic cannabidiol, or CBD, for the treatment of pediatric epilepsies, including21Table of ContentsDravet syndrome. Insys previously advanced its synthetic CBD program, which has received orphan drug designation and Fast Track status by the FDA foruse of CBD as a potential treatment for Dravet syndrome, into a Phase 1/2 clinical trial. Insys initiated Phase 2 development of its CBD product candidate forchildhood absence epilepsy in December of 2017, and plans to initiate a Phase 3 trial in infantile spasms, a pediatric epilepsy syndrome, in the first quarter of2018.We expect ZX008, if approved, to compete on the basis of, among other things, product efficacy and safety, time to market, price, coverage andreimbursement by third-party payors, extent of adverse side effects and convenience of treatment procedures. One or more of our competitors may developother products that compete with ours, obtain necessary approvals for such products from the FDA, or other agencies, if required, more rapidly than we do ordevelop alternative products or therapies that are safer, more effective and/or more cost effective than any products developed by us. The competition that wewill encounter with respect to any of our product candidates that receive the requisite regulatory approval and classification and are marketed will have aneffect on our product prices, market share and results of operations. We may not be able to successfully differentiate any products that we are able to marketfrom those of our competitors, successfully develop or introduce new products that are less costly or offer better results than those of our competitors or offerpurchasers of our products payment and other commercial terms as favorable as those offered by our competitors. In addition, competitors may seek todevelop alternative formulations of our product candidates and/or alternative drug delivery technologies that address our targeted indications.The commercial opportunity for our product candidates could be significantly harmed if competitors are able to develop alternative formulationsand/or drug delivery technologies outside the scope of our products. Compared to us, many of our potential competitors have substantially greater:•capital resources;•research and development resources, expertise and experience, including personnel and technology;•drug development, clinical trial and regulatory resources and experience;•sales and marketing resources and experience;•manufacturing and distribution resources and experience;•name recognition; and•resources, experience and expertise in prosecution and enforcement of intellectual property rights.As a result of these factors, our competitors may obtain regulatory approval of their products more rapidly than we are able to or may obtain patentprotection or other intellectual property rights that limit or block us from developing or commercializing our product candidates. Our competitors may alsodevelop drugs that are more effective, more useful, better tolerated, subject to fewer or less severe side effects, more widely prescribed or accepted or lesscostly than ours and may also be more successful than we are in manufacturing and marketing their products. If we are unable to compete effectively with themarketed therapeutics of our competitors or if such competitors are successful in developing products that effectively compete with any of our productcandidates that are approved, our business, results of operations, financial condition and prospects may be materially adversely affected.If ZX008 receives regulatory approval but does not achieve broad market acceptance or coverage by third-party payors, the revenues that we generate willbe limited.The commercial success of ZX008, if approved by the FDA or other regulatory authorities will depend upon the acceptance of these products byphysicians, patients, healthcare payors and the medical community. Adequate coverage and reimbursement of our approved product by third-party payorswill also be critical for commercial success. The degree of market acceptance of any product candidates for which we may receive regulatory approval willdepend on a number of factors, including:•acceptance by physicians and patients of the product as a safe and effective treatment;•any negative publicity or political action related to our or our competitors’ products;•the relative convenience and ease of administration;•the prevalence and severity of adverse side effects;•demonstration to authorities of the pharmacoeconomic benefits;•demonstration to authorities of the improvement in burden of illness;•limitations or warnings contained in a product’s FDA-approved or European Medicines Agency, or EMA, approved labeling;22Table of Contents•the clinical indications for which a product is approved;•availability and perceived advantages of alternative treatments;•the effectiveness of our or any current or future collaborators’ sales, marketing and distribution strategies;•pricing and cost effectiveness;•our ability to obtain sufficient U.S. third-party payor coverage and reimbursement;•our ability to obtain European countries’ pricing authorities’ coverage and reimbursement; and•the willingness of patients to pay out of pocket in the absence of third-party payor coverage.Our efforts to educate the medical community, U.S. third-party payors and European countries’ health authorities on the benefits of ZX008 or any ofour product candidates for which we obtain marketing approval from the FDA or other regulatory authorities and gain broad market acceptance may requiresignificant resources and may never be successful. If our products do not achieve an adequate level of acceptance by physicians, third-party payors,pharmacists, patients, and the medical community, we may not generate sufficient revenue from these products to become or remain profitable.We have a history of significant net losses and negative cash flow from operations. We cannot predict if or when we will become profitable and anticipatethat our net losses and negative cash flow from operations will continue for at least the next year.We were organized in 2006, began commercialization of Sumavel DosePro in January 2010 and launched the commercial sale of Zohydro ER in theUnited States in March 2014. We sold our Sumavel DosePro business in April 2014 and sold our Zohydro ER business in April 2015. Our business andprospects must be considered in light of the risks and uncertainties frequently encountered by pharmaceutical companies developing and commercializingnew products.Excluding gains from two discrete business divestitures, we have incurred significant net losses from our operations since the company’s inception andhave an accumulated deficit of $572.0 million as of December 31, 2017. In 2017, we used $75.9 million of cash in operations. We expect to continue to incuroperating losses and negative cash flow from operating activities for at least the next year primarily as a result of costs incurred related to the clinicaldevelopment of ZX008. Additionally, in the event that ZX008 is approved in the United States or the European Union, or EU, we will owe milestonepayments under the Zogenix International Limited Sales and Purchase Agreement for ZX008. Our ability to generate revenues from ZX008 will depend on anumber of factors including our ability to successfully complete clinical trials, obtain necessary regulatory approvals and negotiate arrangements with thirdparties to help finance the development of, and market and distribute, any product candidates that receive regulatory approval. In addition, we are subject tothe risk that the marketplace will not accept our products.Because of the numerous risks and uncertainties associated with our commercialization and product development efforts, we are unable to predict theextent of our future losses or when or if we will become profitable, if at all. If we do not generate significant sales from ZX008, our product candidate that mayreceive regulatory approval, there would likely be a material adverse effect on our business, results of operations, financial condition and prospects whichcould result in our inability to continue operations.We rely on third parties to conduct our pre-clinical studies and clinical trials. If these third parties do not successfully carry out their contractual duties ormeet expected deadlines, we may not be able to obtain regulatory approval for or commercialize our product candidates and our business could besubstantially harmed.We have agreements with third-party CROs to conduct our ongoing Phase 3 program for ZX008. We rely heavily on these parties for the execution ofour clinical trials and pre-clinical studies, and control only certain aspects of their activities. Nevertheless, we are responsible for ensuring that each of ourstudies is conducted in accordance with the applicable protocol and regulatory requirements. We and our CROs are required to comply with good clinicalpractice, or GCP, requirements for clinical studies of our product candidates, and good laboratory practice, or GLP, requirements for certain pre-clinicalstudies. The FDA enforces these regulations through periodic inspections of trial sponsors, principal investigators and trial sites. If we or our CROs fail tocomply with applicable regulations, the data generated in our pre-clinical studies and clinical trials may be deemed unreliable and the FDA may require us toperform additional pre-clinical studies or clinical trials before approving our marketing applications. We cannot assure you that, upon inspection, the FDAand similar foreign regulators will determine that any of our clinical trials comply or complied with GCP regulations. In addition, our clinical trials must beconducted with product produced under current good manufacturing practice, or cGMP, regulations, and require a large number of test subjects. Our inabilityto comply with these regulations may require us to repeat clinical trials, which would delay the regulatory approval process.If any of our relationships with these third-party CROs terminates, we may not be able to enter into arrangements with alternative CROs oncommercially reasonable terms, or at all. If CROs do not successfully carry out their contractual duties or23Table of Contentsobligations or meet expected deadlines, if they need to be replaced or if the quality or accuracy of the clinical data they obtain is compromised due to thefailure to adhere to our clinical protocols or regulatory requirements or for other reasons, our clinical trials may be extended, delayed or terminated and wemay not be able to obtain regulatory approval for or successfully commercialize our product candidates. As a result, our results of operations and thecommercial prospects for our product candidates would be harmed, our costs could increase and our ability to generate additional revenues could be delayed.Switching or adding additional CROs can involve substantial cost and require extensive management time and focus. In addition, there is a naturaltransition period when a new CRO commences work. As a result, delays may occur, which can materially impact our ability to meet our desired clinicaldevelopment timelines. Though we carefully manage our relationships with our CROs, there can be no assurance that we will not encounter similarchallenges or delays in the future or that these delays or challenges will not have a material adverse impact on our business, results of operations, financialcondition and prospects.We may engage in strategic transactions that could impact our liquidity, increase our expenses and present significant distractions to our management.From time to time we may consider strategic transactions, such as acquisitions of companies, asset purchases and out-licensing or in-licensing ofproducts, product candidates or technologies. For example, in October 2014, we completed the acquisition of Brabant, which owns worldwide developmentand commercialization rights to ZX008, and in October 2016, we completed an asset purchase agreement to acquire the global rights to a preclinicaldevelopment program for orphan CNS disorders. Additional potential transactions that we may consider include a variety of different business arrangements,including spin-offs, strategic partnerships, joint ventures, restructurings, divestitures, business combinations and investments. Any such transaction mayrequire us to incur non-recurring or other charges, may increase our near and long-term expenditures and may pose significant integration challenges ordisrupt our management or business, which could adversely affect our operations and financial results. For example, these transactions may entail numerousoperational and financial risks, including:•exposure to unknown liabilities;•disruption of our business and diversion of our management’s time and attention in order to develop acquired products, product candidates ortechnologies;•incurrence of substantial debt or dilutive issuances of equity securities to pay for acquisitions;•significant or higher than expected acquisition and integration costs;•write-downs of assets or goodwill or impairment charges;•increased amortization expenses;•difficulty and cost in combining the operations and personnel of any acquired businesses with our operations and personnel;•impairment of relationships with key suppliers or customers of any acquired businesses due to changes in management, personnel and ownership;and•inability to retain key employees of any acquired businesses.Accordingly, although there can be no assurance that we will undertake or successfully complete any additional transactions of the nature describedabove, any additional transactions that we do complete could have a material adverse effect on our business, results of operations, financial condition andprospects.We are dependent on numerous third parties in our manufacturing supply chain, all of which are currently single source suppliers, for the clinical supplyof ZX008, and if we experience problems with any of these suppliers, the development of ZX008 could be delayed.We outsource all manufacturing and packaging of the clinical trial materials for ZX008 to third parties. ZX008, if approved, would require processvalidation, for which there can be no assurance of success. We may never be able to establish additional sources of supply for ZX008.Suppliers are subject to regulatory requirements covering, among other things, testing, quality control and record keeping relating to our productcandidate, and are subject to ongoing inspections by regulatory agencies. Failure by any of our suppliers to comply with applicable regulations may result inlong delays and interruptions, and increase our costs, while we seek to secure another supplier who meets all regulatory requirements, including obtainingregulatory approval to utilize the new supplier. Accordingly, the loss of any of our current suppliers could have a material adverse effect on our business,results of operations, financial condition and prospects.24Table of ContentsReliance on suppliers entails risks to which we would not be subject if we manufactured our product candidate ourselves, including:•reliance on the third parties for regulatory compliance and quality assurance;•the possible breach of the manufacturing agreements by the third parties because of factors beyond our control or the insolvency of any of thesethird parties or other financial difficulties, labor unrest, natural disasters or other factors adversely affecting their ability to conduct their business;and•the possibility of termination or non-renewal of the agreements by the third parties, at a time that is costly or inconvenient for us, because of ourbreach of the manufacturing agreement or based on their own business priorities.If our contract manufacturers or suppliers are unable to provide the quantities of our product candidate required for our clinical trials and, if approved,for commercial sale, on a timely basis and at commercially reasonable prices, and we are unable to find one or more replacement manufacturers or supplierscapable of production at a substantially equivalent cost, in substantially equivalent volumes and quality, and on a timely basis, we would likely be unable tomeet demand for our products and would have to delay or terminate our pre-clinical or clinical trials, and we would lose potential revenue. It may also take asignificant period of time to establish an alternative source of supply for our products, product candidates and components and to have any such new sourceapproved by the FDA or any applicable foreign regulatory authorities. Furthermore, any of the above factors could cause the delay or suspension of initiationor completion of clinical trials, regulatory submissions or required approvals of our product candidates, cause us to incur higher costs and could prevent usfrom commercializing our product candidates successfully.If we are unable to attract and retain key personnel, we may not be able to manage our business effectively or develop our product candidates orcommercialize our products.Our success depends on our continued ability to attract, retain and motivate highly qualified management and key clinical development, regulatory,sales and marketing and other personnel. As of December 31, 2017, we employed 68 full-time employees. Of the full-time employees, 43 were engaged inproduct development, quality assurance and clinical and regulatory activities, 6 were engaged in sales and marketing and 19 were engaged in general andadministrative activities (including business and corporate development). If we are not able to retain our employee base, we may not be able to effectivelymanage our business or be successful in commercializing our products.We are highly dependent on the development, regulatory, commercial and financial expertise of our senior management team. We may not be able toattract or retain qualified management and scientific and clinical personnel in the future due to the intense competition for qualified personnel amongbiotechnology, pharmaceutical and other businesses, especially in the San Francisco Bay Area where we operate. If we are not able to attract, retain andmotivate necessary personnel to accomplish our business objectives, we may experience constraints that will significantly impede the achievement of ourdevelopment and commercialization objectives, our ability to raise additional capital, our ability to implement our business strategy and our ability tomaintain effective internal controls for financial reporting and disclosure controls and procedures as required by the Sarbanes-Oxley Act of 2002, or theSarbanes-Oxley Act. The loss of the services of any members of our senior management team, especially our Chief Executive Officer and President, Stephen J.Farr, Ph.D., could delay or prevent the development and commercialization of ZX008 and our product candidates. Further, if we lose any members of oursenior management team, we may not be able to find suitable replacements, and our business may be harmed as a resultAlthough we have employment agreements with each of our executive officers, these agreements are terminable by them at will at any time with orwithout notice and, therefore, do not provide any assurance that we will be able to retain their services. We do not maintain “key man” insurance policies onthe lives of our senior management team or the lives of any of our other employees. In addition, we have clinical advisors who assist us in formulating ourclinical strategies. These advisors are not our employees and may have commitments to, or consulting or advisory contracts with, other entities that may limittheir availability to us, or may have arrangements with other companies to assist in the development of products that may compete with ours. If we are unableto attract and retain key personnel, our business, results of operations, financial condition and prospects will be adversely affected.Our business and operations would suffer in the event of system failures.Despite the implementation of security measures, our internal computer systems and those of our current and our partners, contractors and consultantsare vulnerable to damage from cyber-attacks, computer viruses, unauthorized access, natural disasters, terrorism, war and telecommunication and electricalfailures. For example, we have in the past experienced failures in our information systems and computer servers, which may have been the result of a cyber-attack. These failures resulted in an interruption of our normal business operations and required substantial expenditure of financial and administrativeresources to remedy. We cannot be sure that similar failures will not occur in the future. System failures, accidents or security breaches can cause interruptionsin our operations, and can result in a material disruption of our commercialization activities, drug development programs and our business operations. Theloss of clinical trial data from completed or future clinical trials could result in delays25Table of Contentsin our regulatory approval and post-market study compliance efforts and significantly increase our costs to recover or reproduce the data. Similarly, we relyon a large number of third parties to supply components for and manufacture our product candidates and conduct clinical trials, and similar events relating totheir computer systems could also have a material adverse effect on our business. To the extent that any disruption or security breach were to result in a lossof, or damage to, our data or applications, or inappropriate disclosure of confidential or proprietary information, we could incur liability and the developmentof our product candidates could be delayed or otherwise adversely affected.Fluctuations in the value of the Euro or U.K. pound sterling could negatively impact our results of operations and increase our costs.We conduct research and development activities in the United Kingdom and other European countries and some of the payments for these activities aredenominated in Euros and U.K. pounds sterling. As a result, we are exposed to foreign exchange risk, and our results of operations may be impacted byfluctuations in the exchange rate between the U.S. dollar and the Euro or U.K. pound sterling, such as the decline in value of the U.K. pound sterlingfollowing the results of the United Kingdom’s referendum on withdrawal from the EU. A significant appreciation in the Euro or U.K. pound sterling relativeto the U.S. dollar will result in higher expenses and cause increases in our net losses. Likewise, to the extent that we generate any revenues denominated inforeign currencies, or become required to make payments in other foreign currencies, fluctuations in the exchange rate between the U.S. dollar and thoseforeign currencies could also negatively impact our results of operations. We currently have not entered into any foreign currency hedging contracts toreduce the effect of changes in foreign currency exchange rates, and foreign currency hedging is inherently risky and may result in unanticipated losses.If we are unable to achieve and maintain adequate levels of coverage and reimbursement for any of our other product candidates for which we may receiveregulatory approval on reasonable pricing terms, their commercial success may be severely hindered.Successful sales of any product candidates for which we may receive regulatory approval will depend on the availability of adequate coverage andreimbursement from third-party payors. Patients who are prescribed medicine for the treatment of their conditions generally rely on third-party payors toreimburse all or part of the costs associated with their prescription drugs. Adequate coverage and reimbursement from governmental healthcare programs,such as Medicare and Medicaid, and commercial payors are critical to new product acceptance. Coverage decisions may depend upon clinical and economicstandards that disfavor new drug products when more established or lower cost therapeutic alternatives are already available or subsequently becomeavailable. Assuming coverage is approved, the resulting reimbursement payment rates might not be adequate or may require co-payments that patients findunacceptably high. Patients are unlikely to use our products unless coverage is provided and reimbursement is adequate to cover a significant portion of thecost of our products.In addition, the market for our products will depend significantly on access to third-party payors’ drug formularies, or lists of medications for whichthird-party payors provide coverage and reimbursement. The industry competition to be included in such formularies often leads to downward pricingpressures on pharmaceutical companies. Also, third-party payors may refuse to include a particular branded drug in their formularies or otherwise restrictpatient access to a branded drug when a less costly generic equivalent or other alternative is available.In addition, regional healthcare authorities and individual hospitals are increasingly using competitive bidding procedures to determine whatpharmaceutical products and which suppliers will be included in their prescription drug and other healthcare programs. This can reduce demand for ourproducts or put pressure on our product pricing, which could negatively affect our business, results of operations, financial condition and prospects.Third-party payors, whether foreign or domestic, or governmental or commercial, are developing increasingly sophisticated methods of controllinghealthcare costs. In addition, in the United States, no uniform policy of coverage and reimbursement for drug products exists among third-party payors.Therefore, coverage and reimbursement for drug products can differ significantly from payor to payor.Further, we believe that future coverage and reimbursement will likely be subject to increased restrictions both in the United States and in internationalmarkets. Third-party coverage and reimbursement for any of our product candidates for which we may receive regulatory approval may not be available oradequate in either the United States or international markets, which could have a material adverse effect on our business, results of operations, financialcondition and prospects.We face potential product liability exposure, and if successful claims are brought against us, we may incur substantial liability if our insurance coveragefor those claims is inadequate.The commercial use of our products and clinical use of our products and product candidates expose us to the risk of product liability claims. This riskexists even if a product or product candidate is approved for commercial sale by the FDA and manufactured in facilities regulated by the FDA such as the casewith Zohydro ER, or an applicable foreign regulatory authority. Our products and product candidates are designed to affect important bodily functions andprocesses. Any side effects, manufacturing defects, misuse or abuse associated with Zohydro ER or our product candidates could result in injury to26Table of Contentsa patient or even death. For example, Zohydro ER is an opioid pain reliever that contains hydrocodone, which is a regulated “controlled substance” under theControlled Substances Act of 1970, or CSA, and could result in harm to patients relating to its potential for abuse. Although we no longer sell Zohydro ERfollowing the sale of the Zohydro ER business in April 2015, we retain all liabilities associated with the Zohydro ER business arising prior to such sale,including possible product liability exposure in connection with sales of Zohydro ER made prior to the sale of the Zohydro ER business. In addition, aliability claim may be brought against us even if our products or product candidates merely appear to have caused an injury.Product liability claims may be brought against us by consumers, health care providers, pharmaceutical companies or others selling or otherwisecoming into contact with our products or product candidates, if approved, among others. If we cannot successfully defend ourselves against product liabilityclaims, we will incur substantial liabilities. In addition, regardless of merit or eventual outcome, product liability claims may result in:•the inability to commercialize our product candidates;•decreased demand for our product candidates, if approved;•impairment of our business reputation;•product recall or withdrawal from the market;•withdrawal of clinical trial participants;•costs of related litigation;•distraction of management’s attention from our primary business;•substantial monetary awards to patients or other claimants; or•loss of revenues.We have obtained product liability insurance coverage for commercial product sales and clinical trials with a $20 million per occurrence and annualaggregate coverage limit. Our insurance coverage may not be sufficient to cover all of our product liability related expenses or losses and may not cover usfor any expenses or losses we may suffer. Moreover, insurance coverage is becoming increasingly expensive, and, in the future, we may not be able tomaintain insurance coverage at a reasonable cost, in sufficient amounts or upon adequate terms to protect us against losses due to product liability. If wedetermine that it is prudent to increase our product liability coverage based on approval of ZX008, or otherwise, we may be unable to obtain this increasedproduct liability insurance on commercially reasonable terms or at all. Large judgments have been awarded in class action or individual lawsuits based ondrugs that had unanticipated side effects, including side effects that are less severe than those of Zohydro ER and our product candidates. A successfulproduct liability claim or series of claims brought against us could cause our stock price to decline and, if judgments exceed our insurance coverage, coulddecrease our cash and have a material adverse effect on our business, results of operations, financial condition and prospects.We may never receive regulatory approval or commercialize our product candidate outside of the United States.We intend to market ZX008 outside of the United States, if approved. For example, ZX008 has received orphan drug designation in the EU, and wecompleted a Phase 3 clinical trial, which included sites in Europe and Australia, in 2017 to support a European MAA. In order to market our products outsideof the United States, we, or any potential partner, must obtain separate regulatory approvals and comply with numerous and varying regulatory requirementsof other countries regarding safety and efficacy and governing, among other things, clinical trials and commercial sales, pricing and distribution of ourproducts. The time required to obtain approval in other countries might differ from and be longer than that required to obtain FDA approval. The regulatoryapproval process in other countries may include all of the risks detailed in these “Risk Factors” regarding FDA approval in the United States, as well as otherrisks.For example, in the European Economic Area, or EEA (comprised of 28 EU member states plus Iceland, Liechtenstein, and Norway), medicinalproducts can only be commercialized after obtaining a Marketing Authorization, or MA. There are two types of MAs:•The Community MA, which is issued by the European Commission through the Centralized · Procedure, based on the opinion of the Committee forMedicinal Products for Human Use, or CHMP, of the EMA and which is valid throughout the entire territory of the EEA. The Centralized Procedureis mandatory for certain types of products, such as biotechnology medicinal products, orphan medicinal products, and medicines that contain a newactive substance indicated for the treatment of AIDS, cancer, neurodegenerative disorders, diabetes, auto-immune and viral diseases. The CentralizedProcedure is optional for products containing a new active substance not yet authorized in the EEA, or for products that constitute a significanttherapeutic, scientific or technical innovation or which are in the interest of public health in the EU. Under the Centralized Procedure the maximumtimeframe for the evaluation of a marketing authorization application is 210 days (excluding clock stops, when additional written or oralinformation is to be27Table of Contentsprovided by the applicant in response to questions asked by the CHMP). Accelerated evaluation might be granted by the CHMP in exceptionalcases, when the authorization of a medicinal product is of major interest from the point of view of public health and in particular from the viewpointof therapeutic innovation. Under the accelerated procedure the standard 210-day review period is reduced to 150 days.•National MAs, which are issued by the competent authorities of the member states of the EEA and only cover their respective territory, are availablefor products not falling within the mandatory scope of the Centralized Procedure. Where a product has already been authorized for marketing in amember state of the EEA, this National MA can be recognized in other member states through the Mutual Recognition Procedure. If the product hasnot received a National MA in any member state at the time of application, it can be approved simultaneously in various Member States through theDecentralized Procedure.In the EEA, upon receiving marketing authorization, new chemical entities generally receive eight years of data exclusivity and an additional twoyears of market exclusivity. If granted, data exclusivity prevents regulatory authorities in the EU from referencing the innovator’s data to assess a genericapplication. During the additional two-year period of market exclusivity, a generic marketing authorization can be submitted, and the innovator’s data maybe referenced, but no generic product can be marketed until the expiration of the market exclusivity. However, there is no guarantee that a product will beconsidered by the EU’s regulatory authorities to be a new chemical entity and qualify for data exclusivity.In the EEA we can take advantage of the hybrid application pathway of the EU Centralized Procedure, which is similar to the FDA’s 505(b)(2)pathway. Hybrid applications may rely in part on the results of pre-clinical tests and clinical trials contained in the authorization dossier of the referenceproduct, but must be supplemented with additional data. In territories where data is not freely available, we or our partners may not have the ability tocommercialize our products without negotiating rights from third parties to refer to their clinical data in our regulatory applications, which could require theexpenditure of significant additional funds. We, or any potential partner, may be unable to obtain rights to the necessary clinical data and may be required todevelop our own proprietary safety effectiveness dossiers. Regulatory approval in one country does not ensure regulatory approval in another, but a failure ordelay in obtaining regulatory approval in one country may have a negative effect on the regulatory process in others.Inability to obtain regulatory approval in other countries or any delay or setback in obtaining such approval could have the same adverse effectsdetailed in these “Risk Factors” regarding FDA approval in the United States. As described above, such effects include the risks that our product candidatesmay not be approved at all or for all requested indications, which could limit the uses of our product candidates and have an adverse effect on theircommercial potential or require costly, post-marketing studies. In addition, we, or any potential partner, may be subject to fines, suspension or withdrawal ofregulatory approvals, product recalls, seizure of products, operating restrictions and criminal prosecution if we are unable to comply with applicable foreignregulatory requirements.Our business involves the use of hazardous materials and we and our third-party manufacturers and suppliers must comply with environmental laws andregulations, which can be expensive and restrict how we do business.Our research and development activities and our third-party manufacturers’ and suppliers’ activities involve the controlled storage, use and disposal ofhazardous materials owned by us, including the components of our product candidates and other hazardous compounds. We and our manufacturers andsuppliers are subject to laws and regulations governing the use, manufacture, storage, handling and disposal of these hazardous materials. In some cases, thesehazardous materials and various wastes resulting from their use are stored at our and our manufacturers’ facilities pending use and disposal. We cannotcompletely eliminate the risk of contamination, which could cause an interruption of our research and development efforts and business operations, injury toour employees and others, environmental damage resulting in costly clean-up and liabilities under applicable laws and regulations governing the use,storage, handling and disposal of these materials and specified waste products. Although we believe that the safety procedures utilized by our third-partymanufacturers for handling and disposing of these materials generally comply with the standards prescribed by these laws and regulations, we cannotguarantee that this is the case or eliminate the risk of accidental contamination or injury from these materials. In such an event, we may be held liable for anyresulting damages and such liability could exceed our resources. We do not currently carry biological or hazardous waste insurance coverage.In connection with the reporting of our financial condition and results of operations, we are required to make estimates and judgments which involveuncertainties, and any significant differences between our estimates and actual results could have an adverse impact on our financial position, results ofoperations and cash flows.Our discussion and analysis of our financial condition and results of operations are based on our consolidated financial statements, which have beenprepared in accordance with generally accepted accounting principles in the United States, or GAAP. The preparation of these consolidated financialstatements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses and related disclosure ofcontingent assets and liabilities. Any28Table of Contentssignificant differences between our actual results and our estimates and assumptions could negatively impact our financial position, results of operations andcash flows.Changes in accounting standards and their interpretations could adversely affect our operating results.Generally accepted accounting principles in the United States are subject to interpretation by the Financial Accounting Standards Board, the AmericanInstitute of Certified Public Accountants, the SEC, and various other bodies that promulgate and interpret appropriate accounting principles. These principlesand related implementation guidelines and interpretations can be highly complex and involve subjective judgments. A change in these principles orinterpretations could have a significant effect on our reported financial results, and could affect the reporting of transactions completed before theannouncement of a change.The results of the United Kingdom’s referendum on withdrawal from the European Union may have a negative effect on global economic conditions,financial markets and our business.We are a company with worldwide operations, which includes significant business operations in Europe, and our wholly owned subsidiary ZogenixEurope Limited is incorporated under the laws of England and Wales. In June 2016, a majority of voters in the United Kingdom elected to withdraw from theEU in a national referendum. The referendum was advisory, and the terms of any withdrawal are subject to a negotiation period that could last at least twoyears after the government of the United Kingdom formally initiates a withdrawal process. Nevertheless, the referendum has created significant uncertaintyabout the future relationship between the United Kingdom and the EU, and has given rise to calls for certain regions within the United Kingdom to preservetheir place in the EU by separating from the United Kingdom as well as for the governments of other EU member states to consider withdrawal.These developments, or the perception that any of them could occur, have had and may continue to have a material adverse effect on global economicconditions and the stability of global financial markets, and could significantly reduce global market liquidity and restrict the ability of key marketparticipants to operate in certain financial markets. Asset valuations, currency exchange rates and credit ratings may be especially subject to increased marketvolatility. Lack of clarity about future U.K. laws and regulations as the United Kingdom determines which EU laws to replace or replicate in the event of awithdrawal, including financial laws and regulations, tax and free trade agreements, intellectual property rights, supply chain logistics, environmental, healthand safety laws and regulations, immigration laws and employment laws, could decrease foreign direct investment in the United Kingdom, increase costs,depress economic activity and restrict our access to capital. If the United Kingdom and the EU are unable to negotiate acceptable withdrawal terms or if otherEU member states pursue withdrawal, barrier-free access between the United Kingdom and other EU member states or among the European economic areaoverall could be diminished or eliminated. Any of these factors could have a material adverse effect on our business, financial condition and results ofoperations and affect our strategy in the European pharmaceutical market.Cyber-attacks or other failures in telecommunications or information technology systems could result in information theft, data corruption and significantdisruption of our business operations.We use information technology, computer systems and networks to process, transmit and store electronic information in connection with our businessactivities. Cyber incidents, including deliberate attacks and attempts to gain unauthorized access to computer systems and networks, have increased infrequency, scope and sophistication in every industry. These threats pose a risk to the security of our systems and networks and the confidentiality,availability and integrity of our data, and may cause a disruption in our operations, harm our reputation and increase our stock trading risk. There can be noassurance that we will be successful in preventing cyber-attacks or successfully mitigating their effects. Similarly, there can be no assurance that our third-party collaborators, distributors and other contractors and consultants will be successful in protecting our data that is stored on their systems. A cyberattack ordestruction or loss of data could have a material adverse effect on our business and prospects. In addition, we may suffer reputational harm or face litigationor adverse regulatory action as a result of cyber-attacks or other data security breaches and may incur significant additional expense to implement further dataprotection measures.Risks Related to Our Financial Position and Capital RequirementsWe have never generated net income from operations or positive cash flow from operations and are dependent upon external sources of financing to fundour business and development.We launched our first approved product, Sumavel DosePro, in January 2010 and subsequently sold the business in April 2014. We launched ourapproved product, Zohydro ER, in March 2014 and subsequently sold the business in April 2015. In September 2017, our remaining revenue-generatingagreement to manufacture and supply Sumavel DosePro to Endo was terminated. We have financed our operations primarily through the proceeds from theissuance of equity securities, the sale of the Sumavel DosePro and Zohydro ER businesses, and debt, and have incurred negative cash flow from operations ineach year since our inception. For the years ended December 31, 2017, 2016 and 2015, we incurred net (loss) income of $(126.8) million, $(69.7) million and$26.1 million, respectively, and our cash used in operating activities was $75.9 million, $72.9 million and29Table of Contents$64.6 million, respectively. As of December 31, 2017, we had an accumulated deficit of $572.0 million. The losses and negative cash flow from operationshave had a material adverse effect on our stockholders’ equity and working capital.We expect to continue to incur net losses and negative cash flow from operating activities for at least the next year to conduct clinical trials to supportregulatory approval of our product candidates. As a result, we will remain dependent upon external sources of financing to fund our business and thedevelopment and commercialization of any approved products and product candidates. To the extent we need to raise additional capital in the future, wecannot ensure that debt or equity financing will be available to us in amounts, at times or on terms that will be acceptable to us, or at all. Any shortfall in ourcash resources could require that we delay or abandon certain development and commercialization activities and could otherwise have a material adverseeffect on our business, results of operations, financial condition and prospects.We will require additional funding in the future to carry out our plan of operations and if we are unable to raise capital when needed, we may be forced todelay, reduce or eliminate our product development programs or future commercialization efforts.Our operations have consumed substantial amounts of cash since inception. We will require additional capital in the future to fund our operations,including:•further development of our product candidates to support potential regulatory approval; and•commercialize any of our product candidates, or any products or product candidates that we may develop, in-license or otherwise acquire, if anysuch product candidates receive regulatory approval.In addition, our estimates of the amount of cash necessary to fund our business and development activities may prove to be wrong, and we could spendour available financial resources much faster than we currently expect. Our future funding requirements will depend on many factors, including, but notlimited to:•the rate of progress and cost of our clinical trials and other product development programs for our product candidates and any future productcandidates that we may develop, in-license or acquire;•the timing of regulatory approval for any of our product candidates and the commercial success of any approved products;•the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights associated with our productcandidates;•the costs of establishing or outsourcing sales, marketing and distribution capabilities, should we elect to do so;•the costs, terms and timing of completion of outsourced commercial manufacturing supply arrangements for any product candidate;•the effect of competing technological and market developments; and•the terms and timing of any additional collaborative, licensing, co-promotion or other arrangements that we may establish, including our ability tosecure a global strategic development and commercialization partner for ZX008.Until we can generate a sufficient amount of product revenue and cash flow from operations and achieve profitability, we expect to finance futurecash needs through public or private equity offerings, debt financings, receivables financings or corporate collaboration and licensing arrangements. Wecannot be certain that additional funding will be available on acceptable terms, or at all. If we are unsuccessful in raising additional funds when needed, wemay be required to significantly delay, reduce the scope of or eliminate one or more of our development programs or our commercialization efforts, or ceaseoperating as a going concern. We also may be required to relinquish, license or otherwise dispose of rights to product candidates or products that we wouldotherwise seek to develop or commercialize ourselves on terms that are less favorable than might otherwise be available. If we raise additional funds byissuing equity securities, substantial dilution to existing stockholders would likely result. If we raise additional funds by incurring debt financing, the termsof the debt may involve significant cash payment obligations as well as covenants and specific financial ratios that may restrict our ability to operate ourbusiness. If we are unable to maintain sufficient financial resources, including by raising additional funds when needed, our business, financial condition andresults of operations will be materially and adversely affected and we may be unable to continue as a going concern.Our results of operations and liquidity needs could be materially negatively affected by market fluctuations and economic downturn.Our results of operations and liquidity could be materially negatively affected by economic conditions generally, both in the United States andelsewhere around the world. Domestic and international equity and debt markets have experienced and may continue to experience heightened volatility andturmoil based on domestic and international economic conditions and concerns. In the event these economic conditions and concerns continue or worsenand the markets continue to remain volatile,30Table of Contentsour results of operations and liquidity could be adversely affected by those factors in many ways, including making it more difficult for us to raise funds ifnecessary, and our stock price may decline. In addition, we maintain significant amounts of cash and cash equivalents at one or more financial institutionsthat are not federally insured. If economic instability continues, we cannot provide assurance that we will not experience losses on these investments.Raising additional funds by issuing securities may cause dilution to existing stockholders and raising funds through lending and licensing arrangementsmay restrict our operations or require us to relinquish proprietary rights.We may need to raise additional funds through public or private equity offerings, debt financings, receivables or royalty financings or corporatecollaboration and licensing arrangements. For example, we currently have an at-the-market sales agreement with Cantor Fitzgerald & Co (“Cantor”) for theoffer and sale of up to $75.0 million of shares of our common stock from time to time. To the extent that we raise additional capital by issuing equitysecurities or convertible debt, your ownership interest in us will be diluted. Debt financing typically contains covenants that restrict operating activities.If we raise additional funds through collaboration, licensing or other similar arrangements, it may be necessary to relinquish potentially valuablerights to our current product or product candidates or proprietary technologies, or grant licenses on terms that are not favorable to us. If adequate funds arenot available, our ability to achieve profitability or to respond to competitive pressures would be significantly limited and we may be required to delay,significantly curtail or eliminate the commercialization and development of our product or product candidates.We may be unable to benefit from favorable U.K. tax legislation.As a company that carries out extensive research and development activities, we benefit from the U.K. research and development tax credit regimefor small and medium-sized companies, whereby we are able to surrender operating losses that arise from our qualifying research and development activitiesfor a payable tax credit of up to 33.35% of eligible research and development expenditures. Qualifying expenditures largely comprise employment costs forresearch staff, consumables and certain internal overhead costs incurred as part of research projects. Certain subcontracted qualifying research expendituresare eligible for a cash rebate of up to 21.67%. The majority of our pipeline research, clinical trials management and manufacturing development activities areeligible for inclusion within these tax credit cash rebate claims. We may not be able to continue to claim research and development tax credits (R&D taxcredits) in the future as we increase our personnel and expand our business because we may no longer qualify as an SME (small or medium-sized enterprise).Our ability to utilize our net operating loss and research and development income tax credit carryforwards may be limited.Under Section 382 of the Internal Revenue Code of 1986, as amended, or the IRC, substantial changes in our ownership may limit the amount of netoperating loss and research and development income tax credit carryforwards, and certain other attributes (such as any future carryovers resulting from anybusiness interest deductions that are disallowed under the recently-enacted U.S. tax legislation) (collectively, tax attributes) that could be utilized annuallyin the future to offset taxable income, if any. Specifically, this limitation may arise in the event of a cumulative change in ownership of our company of morethan 50% within a three-year period as determined under the IRC, which we refer to as an ownership change. Any such annual limitation may significantlyreduce the utilization of these tax attributes before they expire. Prior to our initial public offering in November 2010, we performed an IRC Section 382 and383 analysis and determined that we had one ownership change, which occurred in August 2006 upon the issuance of convertible preferred stock. Weperformed an additional IRC Section 382 and 383 analysis upon the issuance of common stock in our follow-on public offering in September 2011, andtogether with the issuance of common stock in our initial public offering and certain other transactions involving our common stock, resulted in anadditional ownership change. We had a third ownership change as defined by IRC Sections 382 and 383, which occurred in January 2014. There was noforfeiture in federal and California net operating loss carryforwards or research and development income tax credits as a result of the third ownership change.We are in the process of analyzing if an ownership change occurred during 2017. As a result of these ownership changes, our ability to use our then existingtax attributes to offset future taxable income, if any, was limited. Any future equity financing transactions, private placements and other transactions thatoccur within the specified three-year period may trigger additional ownership changes, which could further limit our use of such tax attributes. Any suchlimitations, whether as the result of prior or future offerings of our common stock or sales of common stock by our existing stockholders, could have anadverse effect on our consolidated results of operations in future years. Furthermore, under recently enacted U.S. tax legislation, although the treatment of taxlosses generated before December 31, 2017 has generally not changed, tax losses generated in calendar year 2018 and beyond may only offset 80% of ourtaxable income. This change may require us to pay federal income taxes in future years despite generating a loss for federal income tax purposes in prioryears.Recent U.S. tax legislation may materially adversely affect our financial condition, results of operations and cash flows.Recently-enacted U.S. tax legislation has significantly changed the U.S. federal income taxation of U.S. corporations, including by reducing the U.S.corporate income tax rate, limiting interest deductions, adopting elements of a territorial tax system, imposing a one-time transition tax (or “repatriation tax”)on all undistributed earnings and profits of certain U.S.-31Table of Contentsowned foreign corporations, revising the rules governing net operating losses and the rules governing foreign tax credits, and introducing new anti-baseerosion provisions. Many of these changes are effective immediately, without any transition periods or grandfathering for existing transactions. Thelegislation is unclear in many respects and could be subject to potential amendments and technical corrections, as well as interpretations and implementingregulations by the Treasury and Internal Revenue Service (“IRS”), any of which could lessen or increase certain adverse impacts of the legislation. Inaddition, it is unclear how these U.S. federal income tax changes will affect state and local taxation, which often uses federal taxable income as a startingpoint for computing state and local tax liabilities. Further, there may be other material adverse effects resulting from the legislation that we have not yetidentified.While some of the changes made by the tax legislation may adversely affect the Company in one or more reporting periods and prospectively, otherchanges may be beneficial on a going forward basis. We continue to work with our tax advisors to determine the full impact that the recent tax legislation as awhole will have on us. We urge our investors to consult with their legal and tax advisors with respect to such legislation.Risks Related to Government RegulationZX008 and any of our product candidates are subject to extensive regulation, and we cannot give any assurance that it will receive regulatory approval orbe successfully commercialized.We currently are developing ZX008 for the treatment of seizures associated with Dravet syndrome and LGS. The research, testing, manufacturing,labeling, approval, sale, marketing, distribution and promotion of drug products, among other things, are subject to extensive regulation by the FDA andother regulatory authorities in the United States. We are not permitted to market ZX008 or any of our product candidates in the United States unless and untilwe receive regulatory approval from the FDA. We cannot provide any assurance that we will obtain regulatory approval for any of our product candidates, orthat any such product candidates will be successfully commercialized.Under the policies agreed to by the FDA under the Prescription Drug User Fee Act, or PDUFA, the FDA is subject to a two-tiered system of review timesfor new drugs: standard review and priority review. For drugs that do not contain a new molecular entity, such as ZX008, a standard review means the FDAhas a goal to complete its review of the NDA and respond to the applicant within ten months from the date of receipt of an NDA. The review process and thePDUFA target action date may be extended if the FDA requests or the NDA sponsor otherwise provides additional information or clarification regardinginformation already provided in the submission. The FDA’s review goals are subject to change, and the duration of the FDA’s review may depend on thenumber and type of other NDAs that are submitted to the FDA around the same time period.The FDA may also refer applications for novel products or products which present difficult questions of safety or efficacy to an advisory committee,typically a panel that includes clinicians and other experts, for review, evaluation and a recommendation as to whether the application should be approved.Although the FDA is not bound by the recommendation of an advisory committee, the matters discussed at the advisory committee meeting, and in particularany concerns regarding safety, could limit our ability to successfully commercialize our product candidates subject to advisory committee review.As part of its review of an NDA, the FDA may inspect the facility or facilities where the drug is manufactured. If the FDA’s evaluations of the NDA andthe clinical and manufacturing procedures and facilities are favorable, the FDA will issue an action letter, which will be either an approval letter, authorizingcommercial marketing of the drug for a specified indication, or a Complete Response letter containing the conditions that must be met in order to secureapproval of the NDA. These conditions may include deficiencies identified in connection with the FDA’s evaluation of the NDA submission or the clinicaland manufacturing procedures and facilities. Until any such conditions or deficiencies have been resolved, the FDA may refuse to approve the NDA. If andwhen those conditions have been met to the FDA’s satisfaction, the FDA will issue an approval letter. The FDA has substantial discretion in the drug approvalprocess, including the ability to delay, limit or deny approval of a product candidate for many reasons. For example:•the FDA may not deem a product candidate safe and effective;•the FDA may not find the data from pre-clinical studies and clinical trials sufficient to support approval;•the FDA may require additional pre-clinical studies or clinical trials;•the FDA may not approve of our third-party manufacturers’ processes and facilities; or•the FDA may change its approval policies or adopt new regulations.Our lead product candidate ZX008 and other product candidates, may not be approved even if they achieve their specified endpoints in clinical trials.The FDA may disagree with our trial design and our interpretation of data from clinical32Table of Contentstrials, or may change the requirements for approval even after it has reviewed and commented on the design for our clinical trials. The FDA may also approvea product candidate for fewer or more limited indications than we request or may grant approval contingent on the performance of costly post-approvalclinical trials. In addition, the FDA may not approve the labeling claims that we believe are necessary or desirable for the successful commercialization of ourproduct candidates. Approval may also be contingent on a risk evaluation and mitigation strategy, or REMS program, which can limit the labeling anddistribution of a drug product.ZX008 and any of our product candidates may not achieve their specified endpoints in clinical trials.The safety and effectiveness of ZX008 has been evaluated in a single, continuing, long-term, open-label, study in patients with Dravet syndrome inBelgium. In January 2016, we initiated a Phase 3 clinical trial in North America for ZX008 as an adjunctive treatment of seizures in children with Dravetsyndrome. This followed FDA acceptance of our IND application for ZX008 in December 2015.If we are unable to obtain regulatory approval for ZX008 or any of our product candidates on the timeline we anticipate, we may not be able to executeour business strategy effectively and our ability to generate revenues may be limited.We may not be able to maintain orphan drug designation or obtain or maintain orphan drug exclusivity for ZX008.We have obtained orphan drug designation for ZX008 in the United States and Europe for both the treatment of Dravet syndrome and LGS. In theUnited States, under the Orphan Drug Act, the FDA may designate a product as an orphan drug if it is intended to treat a rare disease or condition affectingfewer than 200,000 individuals in the United States or, if it affects more than 200,000 people, there is no reasonable expectation that costs of research anddevelopment of the drug for the indication can be recovered by sales in the United States. In the EU, a drug may receive orphan designation if the prevalenceof the condition in the EU is of no more than five in 10,000 or it if is unlikely that marketing of the medicine would generate sufficient returns to justify theinvestment needed for its development. Orphan drug designation in the United States confers certain benefits, including tax incentives and waiver of theapplicable application fee upon submission of the product for approval in the rare disease or condition. In the EU, sponsors who obtain orphan designationbenefit from a number of incentives, including protocol assistance and fee reductions.If a product with an orphan drug designation subsequently receives the first marketing approval for the indication for which it has such designation,the product is eligible for a period of marketing exclusivity, which precludes the FDA or EMA from approving another marketing application for the samedrug to treat the same rare disease or condition for that time period, except in limited circumstances. The applicable period is seven years in the United Statesand ten years in Europe. Also, we are only able to attain orphan drug status in Europe if we are able to demonstrate to EMA that ZX008 has incrementalbenefit over any other approved product for that orphan disorder. Our planned study, 1504, to show incremental benefit over stiripentol may not show anybenefit. Currently, only stiripentol has orphan drug status in Europe for treatment of seizures in Dravet syndrome, but others could be approved.The European exclusivity period can be reduced to six years if a drug no longer meets the criteria for orphan drug designation or if the drug issufficiently profitable so that market exclusivity is no longer justified. Orphan drug exclusivity may be lost if the FDA or EMA determines that the request fordesignation was materially defective or if the manufacturer is unable to assure sufficient quantity of the drug to meet the needs of patients with the raredisease or condition.Orphan drug exclusivity may not effectively protect the product from competition in the United States because different drugs can be approved for thesame condition. Even after an orphan drug is approved and granted exclusivity, the FDA and EMA can subsequently approve the same or a similar drug forthe same condition during the exclusivity period if the FDA or the EMA concludes that the later drug is clinically superior in that it is shown to be safer, moreeffective or makes a major contribution to patient care. Orphan drug designation neither shortens the development time or regulatory review time of a drugnor gives the drug any advantage in the regulatory review or approval process.33Table of ContentsAny of our product candidates that receive regulatory approval will be subject to ongoing and continued regulatory review, which may result in significantexpense and limit our ability to commercialize such products.Even after we achieve U.S. regulatory approval for a product, the FDA may still impose significant restrictions on the approved indicated uses forwhich the product may be marketed or on the conditions of approval. For example, a product’s approval may contain requirements for potentially costly post-approval studies and surveillance, including Phase 4 clinical trials, to monitor the safety and efficacy of the product, or the implementation of a REMSprogram. We may also be subject to ongoing FDA obligations and continued regulatory review with respect to the manufacturing, processing, labeling,packaging, distribution, adverse event reporting, storage, advertising, promotion and recordkeeping for any approved product. These requirements mayinclude submissions of safety and other post-marketing information and reports, establishment registration and drug listing, as well as continued compliancewith cGMP for our marketed and investigational products, and with GCP and GLP requirements, which are regulations and guidelines enforced by the FDAfor all of our products in clinical and pre-clinical development, and for any clinical trials that we conduct post-approval. To the extent that a product isapproved for sale in other countries, we may be subject to similar restrictions and requirements imposed by laws and government regulators in thosecountries.In the case of any product candidates containing controlled substances, we and our contract manufacturers will also be subject to ongoing DEAregulatory obligations, including, among other things, annual registration renewal, security, recordkeeping, theft and loss reporting, periodic inspection andannual quota allotments for the raw material for commercial production of our products. In addition, manufacturers of drug products and their facilities aresubject to continual review and periodic inspections by the FDA and other regulatory authorities for compliance with cGMP regulations, QSR requirementsfor medical device components or similar requirements, if applicable. If we or a regulatory agency discovers previously unknown problems with an approvedproduct, such as adverse events of unanticipated severity or frequency, or problems with the facility where, or processes by which, the product ismanufactured, a regulatory agency may impose restrictions on that product, the manufacturer or us, including requiring product recall, notice to physicians,withdrawal of the product from the market or suspension of manufacturing.If we, our product candidates or the manufacturing facilities for our product candidates fail to comply with applicable regulatory requirements, aregulatory agency may:•impose restrictions on the marketing or manufacturing of a product, suspend or withdraw product approvals or revoke necessary licenses;•issue warning letters, show cause notices or untitled letters describing alleged violations, which may be publicly available;•commence criminal investigations and prosecutions;•impose injunctions, suspensions or revocations of necessary approvals or other licenses;•impose fines or other civil or criminal penalties;•suspend any ongoing clinical trials;•deny or reduce quota allotments for the raw material for commercial production of our controlled substance products;•delay or refuse to approve pending applications or supplements to approved applications filed by us;•refuse to permit drugs or precursor chemicals to be imported or exported to or from the United States;•suspend or impose restrictions on operations, including costly new manufacturing requirements; or•seize or detain products or require us to initiate a product recall.In addition, labeling, advertising and promotion of any approved products are subject to regulatory requirements and continuing regulatory review.The FDA strictly regulates the promotional claims that may be made about prescription drug products. In particular, a drug may not be promoted for uses thatare not approved by the FDA as reflected in the product’s approved labeling, although the FDA does not regulate the prescribing practices of physicians. TheFDA and other agencies actively enforce the laws and regulations prohibiting the promotion of off-label uses, and a company that is found to haveimproperly promoted off-label uses may be subject to significant liability, including substantial monetary penalties and criminal prosecution.34Table of ContentsThe FDA’s regulations, policies or guidance may change and new or additional statutes or government regulations may be enacted that could preventor delay regulatory approval of our product candidates or further restrict or regulate post-approval activities. For example, in December 2016, the 21stCentury Cures Act was signed into law, which is intended, among other things, to modernize the regulation of drugs and biologics and to spur innovation. Ifwe are not able to achieve and maintain regulatory compliance, we may not be permitted to market our drugs, which would adversely affect our ability togenerate revenue and achieve or maintain profitability.In addition, we cannot predict the likelihood, nature or extent of adverse government regulation that may arise from pending or future legislation oradministrative action, either in the United States or abroad. For example, certain policies of the current presidential administration may impact our businessand industry. Namely, the current presidential administration has taken several executive actions, including the issuance of a number of Executive Orders,that could impose significant burdens on, or otherwise materially delay, FDA’s ability to engage in routine regulatory and oversight activities such asimplementing statutes through rulemaking, issuance of guidance, and review and approval of marketing applications. It is difficult to predict how theserequirements will be implemented, and the extent to which they will impact the FDA’s ability to exercise its regulatory authority. If these executive actionsimpose constraints on FDA’s ability to engage in oversight and implementation activities in the normal course, our business may be negatively impacted.ZX008 may cause undesirable side effects or have other unexpected properties that could delay or prevent approval or result in post-approval regulatoryaction.If we or others identify undesirable side effects, or other previously unknown problems, caused by ZX008 or any of our other product candidates withthe same or related active ingredients, during development or after obtaining U.S. regulatory approval, a number of potentially significant negativeconsequences could result, including:•regulatory authorities may not permit us to initiate our studies or could put them on hold;•regulatory authorities may not approve, or may withdraw their approval of the product;•regulatory authorities may require us to recall the product;•regulatory authorities may add new limitations for distribution and marketing of the product;•regulatory authorities may require the addition of warnings in the product label or narrowing of the indication in the product label;•we may be required to create a Medication Guide outlining the risks of such side effects for distribution to patients;•we may be required to change the way the product is administered or modify the product in some other way;•we may be required to implement a REMS program;•the FDA may require us to conduct additional clinical trials or costly post-marketing testing and surveillance to monitor the safety or efficacy of theproduct;•we could be sued and held liable for harm caused to patients; and•our reputation may suffer.Any of the above events resulting from undesirable side effects or other previously unknown problems could prevent us from achieving or maintainingmarket acceptance of the affected product, if approved, and could substantially increase the costs of commercializing our product candidates.Healthcare reform measures and changes in policies, funding, staffing and leadership at the FDA and other agencies could hinder or prevent thecommercial success of any of our product candidates that may be approved by the FDA.In the United States, there have been a number of legislative and regulatory changes to the healthcare system in ways that could affect our futureresults of operations and the future results of operations of our customers. There have been and continue to be a number of initiatives at the federal and statelevels that seek to reduce healthcare costs. In March 2010, the Patient Protection and Affordable Care Act, as amended by the Health Care and EducationReconciliation Act, or collectively the PPACA, was signed into law, which includes measures to significantly change the way health care is financed by bothgovernmental and private insurers. Among the provisions of the PPACA of greatest importance to the pharmaceutical industry are the following:35Table of Contents•an annual, nondeductible fee on any entity that manufactures or imports certain branded prescription drugs and biologic agents, apportioned amongthese entities according to their market share in certain government healthcare programs;•an increase in the statutory minimum rebates a manufacturer must pay under the Medicaid Drug Rebate Program to 23% and 13% of the averagemanufacturer price for most branded and generic drugs, respectively;•a new methodology by which rebates owed by manufacturers under the Medicaid Drug Rebate Program are calculated for drugs that are inhaled,infused, instilled, implanted or injected;•a new Medicare Part D coverage gap discount program, in which manufacturers must agree to offer 50% point-of-sale discounts, which, throughsubsequent legislative amendments, will be increased to 70%, starting in 2019, off negotiated prices of applicable brand drugs to eligiblebeneficiaries during their coverage gap period, as a condition for the manufacturer’s outpatient drugs to be covered under Medicare Part D;•extension of manufacturers’ Medicaid rebate liability to covered drugs dispensed to individuals who are enrolled in Medicaid managed careorganizations;•expansion of eligibility criteria for Medicaid programs by, among other things, allowing states to offer Medicaid coverage to additional individualsand by adding new mandatory eligibility categories for certain individuals with income at or below 133% of the Federal Poverty Level, therebypotentially increasing both the volume of sales and manufacturers’ Medicaid rebate liability;•expansion of the entities eligible for discounts under the Public Health Service pharmaceutical pricing program;•new requirements to report certain financial arrangements with physicians and others, including reporting any “transfer of value” made or distributedto prescribers and other healthcare providers and reporting any investment interests held by physicians and their immediate family members duringeach calendar year. Manufacturers are required to report such data to the Centers for Medicare & Medicaid Services, or CMS, by the 90th day of eachcalendar year;•a new requirement to annually report drug samples that manufacturers and distributors provide to physicians;•a licensure framework for follow-on biologic products;•a new Patient-Centered Outcomes Research Institute to oversee, identify priorities in, and conduct comparative clinical effectiveness research, alongwith funding for such research; and•establishment of a Center for Medicare Innovation at CMS to test innovative payment and service delivery models to lower Medicare and Medicaidspending.There have been judicial and Congressional challenges to certain aspects of the PPACA, and we expect there will be additional challenges andamendments to the PPACA in the future, particularly in light of the current presidential administration and U.S. Congress. In addition, Congress couldconsider subsequent legislation to replace repealed elements of the PPACA. At this time, the full effect that the PPACA and any subsequent legislation wouldhave on our business remains unclear.Other legislative changes have also been proposed and adopted in the United States since the PPACA was enacted. For example, in August 2011, theBudget Control Act of 2011, among other things included aggregate reductions to Medicare payments to providers of 2% per fiscal year, which went intoeffect on April 1, 2013, and, due to subsequent legislative amendments to the statute, will remain in effect through 2025 unless additional Congressionalaction is taken. In January 2013, the American Taxpayer Relief Act of 2012, among other things, further reduced Medicare payments to several providers,including hospitals, imaging centers and cancer treatment centers, and increased the statute of limitations period for the government to recover overpaymentsto providers from three to five years.Recently, there has been heightened governmental scrutiny over the manner in which drug manufacturers set prices for their marketed products, whichhas resulted in several Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing, review therelationship between pricing and manufacturer patient programs, and reform government program reimbursement methodologies for drug products.Individual states have also become increasingly active in passing legislation and implementing regulations designed to control pharmaceutical productpricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access, and to encourage importation from othercountries and bulk purchasing. These new laws may result in additional reductions in Medicare and36Table of Contentsother health care funding, which could have a material adverse effect on our customers and accordingly, our financial operations.Furthermore, regulatory authorities’ assessment of the data and results required to demonstrate safety and efficacy can change over time and can beaffected by many factors, such as the emergence of new information, including on other products, changing policies and agency funding, staffing andleadership. We cannot be sure whether future changes to the regulatory environment will be favorable or unfavorable to our business prospects. For example,average review times at the FDA for marketing approval applications have fluctuated over the last ten years, and we cannot predict the review time for any ofour submissions with any regulatory authorities. In addition, review times can be affected by a variety of factors, including budget and funding levels andstatutory, regulatory and policy changes.We may incur liability if our continuing medical or health education programs and/or product promotions are determined, or are perceived, to beinconsistent with regulatory guidelines.The FDA provides guidelines with respect to appropriate promotion and continuing medical and health education activities. Although we endeavor tofollow these guidelines, the FDA or the Office of the Inspector General U.S. Department of Health and Human Services may disagree, and we may be subjectto significant liability, including civil and administrative remedies as well as criminal sanctions. In addition, management’s attention could be diverted andour reputation could be damaged.If we do not comply with federal and state healthcare laws, including fraud and abuse and health information privacy and security laws, we could facesubstantial penalties and our business, results of operations, financial condition and prospects could be adversely affected.As a pharmaceutical company, certain federal and state healthcare laws and regulations pertaining to fraud and abuse and patients’ rights areapplicable to our business. We could be subject to healthcare fraud and abuse and patient privacy regulation by both the federal government and the states inwhich we conduct our business. The laws that may affect our ability to operate include:•the federal Anti-Kickback Statute, which constrains our marketing practices, educational programs, pricing policies, and relationships withhealthcare providers or other entities, by prohibiting, among other things, soliciting, receiving, offering or paying remuneration, directly orindirectly, in cash or in kind, to induce, or in return for, the purchase or recommendation of an item or service reimbursable under a federalhealthcare program, such as the Medicare and Medicaid programs. A person or entity no longer needs to have actual knowledge of the statute orspecific intent to violate it in order to have committed a violation. In addition, the government may assert that a claim including items or servicesresulting from a violation of the federal anti-kickback statute constitutes a false or fraudulent claim for purposes of the False Claims Act;•federal civil and criminal false claims laws and civil monetary penalty laws, which prohibit, among other things, individuals or entities fromknowingly presenting, or causing to be presented, claims for payment from Medicare, Medicaid, or other third-party payors that are false orfraudulent, and which may apply to entities like us which provide coding and billing advice to customers;•the federal Health Insurance Portability and Accountability Act of 1996, or HIPAA, which created new federal criminal statutes that prohibitexecuting a scheme to defraud any healthcare benefit program or making false statements relating to healthcare matters. Similar to the federal Anti-Kickback Statute, a person or entity no longer needs to have actual knowledge of the statute or specific intent to violate it in order to havecommitted a violation;•HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act, and its implementing regulations, which imposecertain requirements relating to the privacy, security and transmission of individually identifiable health information;•federal “sunshine” requirements that require drug manufacturers to report and disclose any “transfer of value” made or distributed to physicians andteaching hospitals, and any investment or ownership interests held by such physicians and their immediate family members. Manufacturers arerequired to report data to the government by the 90th day of each calendar year; and•state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws which may apply to items or services reimbursedby any third-party payor, including commercial insurers, and state laws governing the privacy and security of health information in certaincircumstances, many of which differ from each other in significant ways and often are not preempted by HIPAA, thus complicating complianceefforts.37Table of ContentsBecause of the breadth of these laws and the narrowness of the statutory exceptions and safe harbors available under the U.S. federal Anti-KickbackStatute, it is possible that some of our business activities could be subject to challenge under one or more of such laws.In addition, there has been a recent trend of increased state regulations that require drug manufacturers to file reports with states regarding pricing andmarketing information, and require the tracking and reporting of gifts, compensation and other remuneration to physicians. Certain states mandateimplementation of commercial compliance programs to ensure compliance with these laws and impose restrictions on drug manufacturer marketing practicesand tracking and reporting of gifts, compensation and other remuneration to physicians. The shifting commercial compliance environment and the need tobuild and maintain robust and expandable systems to comply with multiple jurisdictions with different compliance and/or reporting requirements increasesthe possibility that a healthcare company may be found out of compliance of one or more of the requirements.To the extent that any product we make is sold in a foreign country, we may be subject to similar foreign laws and regulations. If we or our operationsare found to be in violation of any of the laws described above or any other governmental regulations that apply to us, we may be subject to penalties,including civil and criminal penalties, damages, fines, exclusion from participation in U.S. federal or state health care programs, and the curtailment orrestructuring of our operations. Any penalties, damages, fines, curtailment or restructuring of our operations could materially adversely affect our ability tooperate our business and our financial results. Although compliance programs can mitigate the risk of investigation and prosecution for violations of theselaws, the risks cannot be entirely eliminated. Any action against us for violation of these laws, even if we successfully defend against it, could cause us toincur significant legal expenses and divert our management’s attention from the operation of our business. Moreover, achieving and sustaining compliancewith applicable federal and state privacy, security and fraud laws may prove costly.Import/export regulations and tariffs may change and increase our costs.We are subject to risks associated with the regulations relating to the import and export of products and materials. We cannot predict whether theimport and/or export of our products will be adversely affected by changes in, or enactment of, new quotas, duties, taxes or other charges or restrictionsimposed by any country in the future. Any of these factors could adversely affect our business, results of operations, financial condition and prospects.Risks Related to Intellectual PropertyOur success depends in part on our ability to protect our intellectual property. It is difficult and costly to protect our proprietary rights and technology,and we may not be able to ensure their protection.Our commercial success depends in large part on obtaining and maintaining patent, trademark and trade secret protection of our product candidates,their respective components, formulations, methods used to manufacture them and methods of treatment, as well as successfully defending these patentsagainst third-party challenges. Our ability to stop unauthorized third parties from making, using, selling, offering to sell or importing our product candidatesis dependent upon the extent to which we have rights under valid and enforceable patents or trade secrets that cover these activities.We in-licensed certain data from a continuing, long-term, open-label study in 15 Dravet syndrome patients, as well as certain intellectual propertyrelated to fenfluramine for the treatment of Dravet syndrome from the Universities of Antwerp and Leuven in Belgium, or the Universities.Prior to receiving rights to 4 U.S. patents in 2017, we did not own or control any issued patents covering ZX008 or its use. There is no guarantee thatany of our pending applications will issue as patents. The patents covering the active pharmaceutical ingredient, or API, in ZX008 have expired and thereforeit is not subject to patent protection. The initial applications covering methods of treatment using ZX008 were licensed by us and not written by ourattorneys. Neither we nor our licensors had control over the drafting and initial prosecution of these applications. Further, the counsel previously handlingthe matter might not have given the same attention to the drafting and prosecution to these applications as we would have if we had been the owners andoriginators of the applications and had control over the drafting and prosecution. In addition, the former counsel handling the matter may not have beencompletely familiar with U.S. patent law or the patent law in various countries, possibly resulting in inadequate disclosure and/or filing of applications attimes which do not meet appropriate priority requirements. The named inventors on the pending applications and others involved in the protection of theintellectual property related to ZX008 did not and may still not have sufficient knowledge relating to preferred procedures related to the protection ofintellectual property. They published papers which adversely affected our rights. Although they have been advised with respect to procedures going forward,we cannot directly control their actions. All of these factors and others could result in the inability to obtain the issuance of additional applications in theUnited States or elsewhere in the world.38Table of ContentsThe patent positions of pharmaceutical, biopharmaceutical and medical device companies can be highly uncertain and involve complex legal andfactual questions for which important legal principles remain unresolved. No consistent policy regarding the breadth of claims allowed in patents in thesefields has emerged to date in the United States. There have been recent changes regarding how patent laws are interpreted, and both the U.S. Patent andTrademark Office, or USPTO, and Congress have recently made significant changes to the patent system. There have been three U.S. Supreme Court decisionsthat now show a trend of the Supreme Court which is distinctly negative on patents. The trend of these decisions along with resulting changes inpatentability requirements being implemented by the USPTO could make it increasingly difficult for us to obtain and maintain patents on our products. Wecannot accurately predict future changes in the interpretation of patent laws or changes to patent laws which might be enacted into law. Those changes maymaterially affect our patents, our ability to obtain patents and/or the patents and applications of our collaborators and licensors. The patent situation in thesefields outside the United States is even more uncertain. Changes in either the patent laws or in interpretations of patent laws in the United States and othercountries may diminish the value of our intellectual property or narrow the scope of our patent protection. Accordingly, we cannot predict the breadth ofclaims that may be allowed or enforced in the patents we own or to which we have a license or third-party patents.The degree of future protection for our proprietary rights is uncertain because legal means afford only limited protection and may not adequatelyprotect our rights or permit us to gain or keep our competitive advantage. For example:•others may be able to make or use compounds that are the same or similar to the pharmaceutical compounds used in our product candidates but thatare not covered by the claims of our patents or our in-licensed patents;•the APIs in ZX008 are, or may soon become, commercially available in generic drug products, and no patent protection will be available withoutregard to formulation or method of use;•we or our licensors, as the case may be, may not be able to detect infringement against our patents or in-licensed patents, which may be especiallydifficult for manufacturing processes or formulation patents;•we or our licensors, as the case may be, might not have been the first to make the inventions covered by our owned or in-licensed issued patents orpending patent applications;•we or our licensors, as the case may be, might not have been the first to file patent applications for these inventions;•others may independently develop similar or alternative technologies or duplicate any of our technologies;•it is possible that our pending patent applications will not result in issued patents;•it is possible that our owned or in-licensed U.S. patents are not Orange-Book eligible;•it is possible that there are dominating patents to ZX008 of which we are not aware;•it is possible that there are prior public disclosures that could invalidate our or our licensors’ patents, as the case may be, or parts of our or theirpatents;•it is possible that others may circumvent our owned or in-licensed patents;•it is possible that there are unpublished applications or patent applications maintained in secrecy that may later issue with claims covering ourproducts or technology similar to ours;•the claims of our owned or in-licensed issued patents or patent applications, if and when issued, may not cover our system or products or our systemof product candidates;•our owned or in-licensed issued patents may not provide us with any competitive advantages, or may be narrowed in scope, be held invalid orunenforceable as a result of legal administrative challenges by third parties;•we may not develop additional proprietary technologies for which we can obtain patent protection; or•the patents of others may have an adverse effect on our business.We also may rely on trade secrets to protect our technology, especially where we do not believe patent protection is appropriate or obtainable.However, trade secrets are difficult to protect, and we have limited control over the protection of trade secrets used by our licensors, collaborators andsuppliers. Although we use reasonable efforts to protect our trade secrets, our employees, consultants, contractors, outside scientific collaborators and otheradvisors may unintentionally or willfully disclose our information to competitors. Enforcing a claim that a third party illegally obtained and is using any ofour trade39Table of Contentssecrets is expensive and time consuming, and the outcome is unpredictable. In addition, state laws in the Unites States vary, and their courts as well as courtsoutside the United States are sometimes less willing to protect trade secrets. Moreover, our competitors may independently develop equivalent knowledge,methods and know-how. If our confidential or proprietary information is divulged to or acquired by third parties, including our competitors, our competitiveposition in the marketplace will be harmed and our ability to successfully penetrate our target markets could be severely compromised.If any of our owned or in-licensed patents are found to be invalid or unenforceable, or if we are otherwise unable to adequately protect our rights, itcould have a material adverse impact on our business and our ability to commercialize or license our technology and products.If we fail to comply with our obligations in our intellectual property licenses with third parties, we could lose license rights that are important to ourbusiness.Our existing license with the Universities impose various diligence, milestone payment, royalty, insurance and other obligations on us. If we fail tocomply with these obligations, our licensors may have the right to terminate the license, in which event we would not be able to develop or market theaffected products. If we lose such license rights, our business, results of operations, financial condition and prospects may be materially adversely affected.We may enter into additional licenses in the future and if we fail to comply with obligations under those agreements, we could suffer similar consequences.We may incur substantial costs as a result of litigation or other proceedings relating to patent and other intellectual property rights, and we may be unableto protect our rights to our products and technology.If we or our collaborators or licensors choose to go to court to stop a third party from using the inventions claimed in our owned or in-licensed patents,that third party may ask the court to rule that the patents are not infringed, invalid and/or should not be enforced against that third party. These lawsuits areexpensive and would consume time and other resources even if we or they, as the case may be, were successful in stopping the infringement of these patents.In addition, there is a risk that the court will decide that these patents are not valid and that we or they, as the case may be, do not have the right to stop othersfrom using the inventions.There is also the risk that, even if the validity of these patents is upheld, the court will refuse to stop the third party on the ground that such third-party’s activities do not infringe our owned or in-licensed patents. In addition, the U.S. Supreme Court has recently changed some tests regarding grantingpatents and assessing the validity of patents. As a consequence, issued patents may be found to contain invalid claims according to the newly revisedstandards. Some of our own or in-licensed patents may be subject to challenge and subsequent invalidation or significant narrowing of claim scope in areexamination or other post-grant proceeding before the USPTO, or during litigation, under the revised criteria which make it more difficult to obtain patents.We may also not be able to detect infringement of our own or in-licensed patents, which may be especially difficult for methods of manufacturing orformulation products. While we intend to take actions reasonably necessary to enforce our patent rights, we depend, in part, on our licensors andcollaborators to protect a substantial portion of our proprietary rights.If we are sued for infringing intellectual property rights of third parties, it will be costly and time consuming, and an unfavorable outcome in thatlitigation would have a material adverse effect on our business.Our commercial success depends upon our ability and the ability of our collaborators to develop, manufacture, market and sell our product candidateand use our proprietary technologies without infringing the proprietary rights of third parties. Numerous U.S. and foreign issued patents and pending patentapplications, which are owned by third parties, exist in the fields relating to ZX008. As the medical device, biotechnology and pharmaceutical industriesexpand and more patents are issued, the risk increases that others may assert that our products or product candidates infringe the patent rights of others.Moreover, it is not always clear to industry participants, including us, which patents cover various types of medical devices, drugs, products or their methodsof use. Thus, because of the large number of patents issued and patent applications filed in our fields, there may be a risk that third parties may allege theyhave patent rights encompassing our products, product candidates, technology or methods.In addition, there may be issued patents of third parties of which we are currently unaware, that are infringed or are alleged to be infringed by ourproduct candidate or proprietary technologies. Because some patent applications in the United States may be maintained in secrecy until the patents areissued, patent applications in the United States and many foreign jurisdictions are typically not published until eighteen months after filing, and publicationsin the scientific literature often lag behind actual discoveries, we cannot be certain that others have not filed patent applications for technology covered byour owned and in-licensed issued patents or our pending applications, or that we or, if applicable, a licensor were the first to invent the technology. Ourcompetitors may have filed, and may in the future file, patent applications covering our product candidates40Table of Contentsor technology similar to ours. Any such patent application may have priority over our owned and in-licensed patent applications or patents, which couldfurther require us to obtain rights to issued patents covering such technologies. If another party has filed a U.S. patent application on inventions similar tothose owned or in-licensed to us, we or, in the case of in-licensed technology, the licensor may have to participate in an interference proceeding declared bythe USPTO to determine priority of invention in the United States. The costs of these proceedings could be substantial, and it is possible that suchproceedings may be decided against us if the other party had independently arrived at the same or similar invention prior to our own or, if applicable, ourlicensor’s invention, resulting in a loss of our U.S. patent position with respect to such inventions. In addition, if another party has reason to assert asubstantial new question of patentability against any of our claims in our owned and in-licensed U.S. patents, the third party can request that the USPTOreexamine the patent claims, which may result in a loss of scope of some claims or a loss of the entire patent. In addition to potential infringement claims,interference and reexamination proceedings, we may become a party to patent opposition proceedings in the European Patent Office, Australian Patent Officeor other jurisdictions where either our patents are challenged, or we are challenging the patents of others. The costs of these proceedings could be substantial,and it is possible that our efforts would be unsuccessful. We may be exposed to, or threatened with, future litigation by third parties having patent or otherintellectual property rights alleging that our product candidates and/or proprietary technologies infringe their intellectual property rights. These lawsuits arecostly and could adversely affect our results of operations and divert the attention of managerial and technical personnel. There is a risk that a court woulddecide that we or our commercialization partners are infringing the third party’s patents and would order us or our partners to stop the activities covered bythe patents. In addition, there is a risk that a court will order us or our partners to pay the other party damages for having violated the other party’s patents.If a third-party’s patent was found to cover our product candidate, proprietary technologies or their uses, we or our collaborators could be enjoined bya court and required to pay damages and could be unable to commercialize our product candidates or use our proprietary technologies unless we or theyobtained a license to the patent. A license may not be available to us or our collaborators on acceptable terms, if at all. In addition, during litigation, thepatent holder could obtain a preliminary injunction or other equitable relief which could prohibit us from making, using or selling our products, technologiesor methods pending a trial on the merits, which could be years away.There is a substantial amount of litigation involving patent and other intellectual property rights in the device, biotechnology and pharmaceuticalindustries generally. If a third party claims that we or our collaborators infringe its intellectual property rights, we may face a number of issues, including, butnot limited to:•infringement and other intellectual property claims which, regardless of merit, may be expensive and time-consuming to litigate and may divert ourmanagement’s attention from our core business;•substantial damages for infringement, which we may have to pay if a court decides that the product at issue infringes on or violates the third party’srights, and if the court finds that the infringement was willful, we could be ordered to pay treble damages and the patent owner’s attorneys’ fees;•a court order prohibiting us from selling or licensing the product unless the third party licenses its patent rights to us, which it is not required to do;•if a license is available from a third party, we may have to pay substantial royalties, upfront fees and/or grant cross-licenses to intellectual propertyrights for our products; and•redesigning our products or processes so they do not infringe, which may not be possible or may require substantial monetary expenditures and time.Some of our competitors may be able to sustain the costs of complex patent litigation more effectively than we can because they have substantiallygreater resources. In addition, any uncertainties resulting from the initiation and continuation of any litigation could have a material adverse effect on ourability to raise the funds necessary to continue our operations or otherwise have a material adverse effect on our business, results of operations, financialcondition and prospects.41Table of ContentsObtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment and otherrequirements imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for non-compliance with theserequirements.Periodic maintenance fees on our owned and in-licensed patents are due to be paid to the USPTO in several stages over the lifetime of the patents.Future maintenance fees will also need to be paid on other patents which may be issued to us or our licensors. We have systems in place to remind us to paythese fees, and we employ outside firms to remind us or our in-licensor to pay annuity fees due to foreign patent agencies on our pending foreign patentapplications. The USPTO and various foreign governmental patent agencies require compliance with a number of procedural, documentary, fee payment andother similar provisions during the patent application process. In many cases, an inadvertent lapse can be cured by payment of a late fee or by other means inaccordance with the applicable rules. However, there are situations in which noncompliance can result in abandonment or lapse of the patent or patentapplication, resulting in partial or complete loss of patent rights in the relevant jurisdiction. In such an event, our competitors might be able to enter themarket and this circumstance would have a material adverse effect on our business.We also may rely on trade secrets and confidentiality agreements to protect our technology and know-how, especially where we do not believe patentprotection is appropriate or obtainable. However, trade secrets are difficult to protect, and we have limited control over the protection of trade secrets used byour licensors, collaborators and suppliers. Although we use reasonable efforts to protect our trade secrets, our employees, consultants, contractors, outsidescientific collaborators and other advisors may unintentionally or willfully disclose our information to competitors. Enforcing a claim that a third partyillegally obtained and is using any of our trade secrets is expensive and time consuming, and the outcome is unpredictable. In addition, courts outside theUnited States are sometimes less willing to protect trade secrets. Moreover, our competitors may independently develop equivalent knowledge, methods andknow-how. If our confidential or proprietary information is divulged to or acquired by third parties, including our competitors, our competitive position inthe marketplace will be harmed and our ability to successfully generate revenues from our product candidates, if approved by the FDA or other regulatoryauthorities, could be adversely affected.We may be subject to claims that our employees have wrongfully used or disclosed alleged trade secrets of their former employers.As is common in the device, biotechnology and pharmaceutical industries, we employ individuals who were previously employed at other device,biotechnology or pharmaceutical companies, including our competitors or potential competitors. Although no claims against us are currently pending, wemay be subject to claims that these employees or we have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of theirformer employers. Litigation may be necessary to defend against these claims. Even if we are successful in defending against these claims, litigation couldresult in substantial costs and be a distraction to management, which would adversely affect our financial condition.Risks Relating to the Securities Markets and an Investment in Our StockThe market price of our common stock has fluctuated and is likely to continue to fluctuate substantially.The market prices for securities of biotechnology and pharmaceutical companies have historically been highly volatile, and the market has recentlyexperienced significant price and volume fluctuations that are unrelated to the operating performance of particular companies. Since the commencement oftrading in connection with our initial public offering in November 2010, the publicly traded shares of our common stock have themselves experiencedsignificant price and volume fluctuations. During the year ended December 31, 2017, the price per share for our common stock on the Nasdaq Global Markethas ranged from a low sale price of $7.70 to a high sale price of $43.35. This market volatility is likely to continue. These and other factors could reduce themarket price of our common stock, regardless of our operating performance. In addition, the trading price of our common stock could change significantly,both over short periods of time and the longer term, due to many factors, including those described elsewhere in this “Risk Factors” section and thefollowing:•FDA or international regulatory actions and whether and when we receive regulatory approval for ZX008;•the development status of ZX008, including the results from our clinical trials;•variations in the level of expenses related to ZX008 clinical development programs, including relating to the timing of invoices from, and otherbilling practices of, our CROs and clinical trial sites;•changes in operating performance and stock market valuations of other pharmaceutical companies and price and volume fluctuations in the overallstock market;•deviations from securities analysts’ estimates or the impact of other analyst comments;•ratings downgrades by any securities analysts who follow our common stock;•additions or departures of key personnel;42Table of Contents•third-party payor coverage and reimbursement policies;•developments concerning current or future strategic collaborations, and the timing of payments we may make or receive under these arrangements;•developments affecting our contract manufacturers, component fabricators and service providers;•the development and sustainability of an active trading market for our common stock;•future sales of our common stock by our officers, directors and significant stockholders;•other events or factors, including those resulting from war, incidents of terrorism, natural disasters, security breaches, system failures or responses tothese events;•changes in accounting principles; and•discussion of us or our stock price by the financial and scientific press and in online investor communities.In addition, the stock markets, and in particular the Nasdaq Global Market, have experienced extreme price and volume fluctuations that have affectedand continue to affect the market prices of equity securities of many pharmaceutical companies. Stock prices of many pharmaceutical companies havefluctuated in a manner unrelated or disproportionate to the operating performance of those companies. The realization of any of the above risks or any of abroad range of other risks, including those described in these “Risk Factors” could have a dramatic and material adverse impact on the market price of ourcommon stock.Our quarterly operating results may fluctuate significantly.Our quarterly operating results are difficult to predict and may fluctuate significantly from period to period, particularly because the success and costsof our ZX008 development programs are uncertain and therefore our future prospects are uncertain. Our net loss and other operating results will be affected bynumerous factors, including:•variations in the level of development and/or regulatory expenses related to ZX008 development programs;•results of clinical trials for ZX008;•any intellectual property infringement lawsuit in which we may become involved;•the level of underlying demand for any of our product candidates that may receive regulatory approval;•our ability to control production spending and underutilization of production capacity;•those of our competitors; and•our execution of any collaborative, licensing or similar arrangements, and the timing of payments we may make or receive under these arrangements.If our quarterly operating results fall below the expectations of investors or securities analysts, the price of our common stock could declinesubstantially. Furthermore, any quarterly fluctuations in our operating results may, in turn, cause the price of our stock to fluctuate substantially.We may become involved in securities class action litigation that could divert management’s attention and adversely affect our business and could subjectus to significant liabilities.The stock markets have experienced significant price and volume fluctuations that have affected the market prices for the common stock ofpharmaceutical companies. These broad market fluctuations as well a broad range of other factors, including the realization of any of the risks described inthese “Risk Factors,” may cause the market price of our common stock to decline. In the past, securities class action litigation has often been brought againsta company following a decline in the market price of its securities. This risk is especially relevant for us because biotechnology and pharmaceuticalcompanies generally experience significant stock price volatility. We may become involved in this type of litigation in the future. Litigation often isexpensive and diverts management’s attention and resources, which could adversely affect our business. Any adverse determination in any such litigation orany amounts paid to settle any such actual or threatened litigation could require that we make significant payments.If securities or industry analysts do not publish research or publish inaccurate or unfavorable research about our business, our stock price and tradingvolume could decline.The trading market for our common stock will depend in part on the research and reports that securities or industry analysts publish about us or ourbusiness. As of December 31, 2017, we had research coverage by only 5 securities analysts. If these securities analysts cease coverage of our company, thetrading price for our stock would be negatively impacted. If one or more of the analysts who covers us downgrades our stock or publishes inaccurate orunfavorable research about our business, our stock price would likely decline. If one or more of these analysts ceases coverage of us or fails to publish reportson us regularly, demand for our stock could decrease, which could cause our stock price and trading volume to decline.43Table of ContentsFuture sales of our common stock or securities convertible or exchangeable for our common stock may depress our stock price.Persons who were our stockholders prior to the sale of shares in our initial public offering in November 2010 continue to hold a substantial number ofshares of our common stock that they are able to sell in the public market, subject in some cases to certain legal restrictions. Significant portions of theseshares are held by a small number of stockholders. If these stockholders sell, or indicate an intention to sell, substantial amounts of our common stock in thepublic market, the trading price of our common stock could decline. The perception in the market that these sales may occur could also cause the tradingprice of our common stock to decline. As of December 31, 2017, we had 34,807,509 shares of common stock outstanding. The majority of these shares arefreely tradeable, without restriction, in the public market.In addition, shares of common stock that are either subject to outstanding options or reserved for future issuance under our employee benefit plans areeligible for sale in the public market to the extent permitted by the provisions of various vesting schedules and Rule 144 and Rule 701 under the SecuritiesAct of 1933, as amended, or the Securities Act, and, in any event, we have filed a registration statement permitting shares of common stock issued on exerciseof options to be freely sold in the public market. If these additional shares of common stock are sold, or if it is perceived that they will be sold, in the publicmarket, the trading price of our common stock could decline.Our directors and executive officers may establish programmed selling plans under Rule 10b5-1 of the Securities Exchange Act of 1934, as amended, orthe Exchange Act, for the purpose of effecting sales of our common stock. Any sales of securities by these stockholders, warrantholders or executive officersand directors, or the perception that those sales may occur, could have a material adverse effect on the trading price of our common stock.Anti-takeover provisions under our charter documents and Delaware law could delay or prevent a change of control which could limit the market price ofour common stock and may prevent or frustrate attempts by our stockholders to replace or remove our current management.Our amended and restated certificate of incorporation and amended and restated bylaws contain provisions that could delay or prevent a change ofcontrol of our company or changes in our board of directors that our stockholders might consider favorable. Some of these provisions include:•a board of directors divided into three classes serving staggered three-year terms, such that not all members of the board will be elected at one time;•a prohibition on stockholder action through written consent, which requires that all stockholder actions be taken at a meeting of our stockholders;•a requirement that special meetings of stockholders be called only by the chairman of the board of directors, the chief executive officer, the presidentor by a majority of the total number of authorized directors;•advance notice requirements for stockholder proposals and nominations for election to our board of directors;•a requirement that no member of our board of directors may be removed from office by our stockholders except for cause and, in addition to anyother vote required by law, upon the approval of not less than 66 2/3% of all outstanding shares of our voting stock then entitled to vote in theelection of directors;•a requirement of approval of not less than 66 2/3% of all outstanding shares of our voting stock to amend any bylaws by stockholder action or toamend specific provisions of our certificate of incorporation; and•the authority of the board of directors to issue preferred stock on terms determined by the board of directors without stockholder approval and whichpreferred stock may include rights superior to the rights of the holders of common stock.In addition, because we are incorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporate Law, whichmay prohibit certain business combinations with stockholders owning 15% or more of our outstanding voting stock. These anti-takeover provisions andother provisions in our amended and restated certificate of incorporation and amended and restated bylaws could make it more difficult for stockholders orpotential acquirers to obtain control of our board of directors or initiate actions that are opposed by the then- current board of directors and could also delayor impede a merger, tender offer or proxy contest involving our company. These provisions could also discourage proxy contests and make it more difficultfor you and other stockholders to elect directors of your choosing or cause us to take other corporate actions you desire. Any delay or prevention of a changeof control transaction or changes in our board of directors could cause the market price of our common stock to decline.We have never paid dividends on our capital stock, and we do not anticipate paying any cash dividends in the foreseeable future.The continued operation and expansion of our business will require substantial funding. Investors seeking cash dividends in the foreseeable futureshould not purchase our common stock. We have paid no cash dividends on any of our classes of44Table of Contentscapital stock to date and we currently intend to retain our available cash to fund the development and growth of our business. Any determination to paydividends in the future will be at the discretion of our board of directors and will depend upon results of operations, financial condition, contractualrestrictions, restrictions imposed by applicable law and other factors our board of directors deems relevant. We do not anticipate paying any cash dividendson our common stock in the foreseeable future. Any return to stockholders will therefore be limited to the appreciation in the market price of their stock,which may never occur.We have incurred and will continue to incur significant increased costs as a result of operating as a public company, and our management is required todevote substantial time to meet compliance obligations.As a public company, we have incurred and will continue to incur significant legal, accounting and other expenses. We are subject to the reportingrequirements of the Exchange Act, the Sarbanes-Oxley Act, as well as rules subsequently implemented by the SEC and the Nasdaq Stock Market, or Nasdaq,that impose significant requirements on public companies, including requiring establishment and maintenance of effective disclosure and financial controlsand changes in corporate governance practices. The Exchange Act requires, among other things, that we file annual, quarterly and current reports with respectto our business and financial condition. In addition, on July 21, 2010, the Dodd-Frank Wall Street Reform and Protection Act, or the Dodd-Frank Act, wasenacted. There are significant corporate governance and executive compensation-related provisions in the Dodd-Frank Act that require the SEC to adoptadditional rules and regulations in these areas. The requirements of these rules and regulations have increased and will continue to increase our legal andfinancial compliance costs, make some activities more difficult, time-consuming or costly and may also place considerable strain on our personnel, systemsand resources. Our management and other personnel have devoted and will continue to devote a substantial amount of time to these new complianceinitiatives. In addition, we expect these rules and regulations to make it more difficult and more expensive for us to obtain director and officer liabilityinsurance, and we may be required to accept reduced policy limits and coverage or incur substantially higher costs to obtain the same or similar coverage. Asa result, it may be more difficult for us to attract and retain qualified people to serve on our board of directors, our board committees or as executive officers.The Sarbanes-Oxley Act requires, among other things, that we maintain effective internal controls for financial reporting and disclosure controls andprocedures. Ensuring that we have adequate internal financial and accounting controls and procedures in place is a costly and time-consuming effort thatneeds to be re-evaluated frequently. In particular, commencing in fiscal 2011, we performed system and process evaluation and testing of our internalcontrols over financial reporting which allowed management to report on the effectiveness of our internal controls over financial reporting, as required bySection 404 of the Sarbanes-Oxley Act, or Section 404. Our future testing may reveal deficiencies in our internal controls over financial reporting that aredeemed to be material weaknesses or that may require prospective or retroactive changes to our consolidated financial statements or identify other areas forfurther attention or improvement. We expect to incur significant expense and devote substantial management effort toward ensuring compliance withSection 404. Pursuant to Section 404(c) of the Sarbanes-Oxley Act, our independent registered public accounting firm is required to deliver an attestationreport on the effectiveness of our internal control over financial reporting. We currently do not have an internal audit function, and we may need to hireadditional accounting and financial staff with appropriate public company experience and technical accounting knowledge. Implementing any appropriatechanges to our internal controls may require specific compliance training for our directors, officers and employees, entail substantial costs to modify ourexisting accounting systems, and take a significant period of time to complete. Such changes may not, however, be effective in maintaining the adequacy ofour internal controls, and any failure to maintain that adequacy, or consequent inability to produce accurate consolidated financial statements or otherreports on a timely basis, could increase our operating costs and could materially impair our ability to operate our business. Moreover, effective internalcontrols are necessary for us to produce reliable financial reports and are important to help prevent fraud. If we are not able to comply with the requirementsof Section 404 in a timely manner, or if we or our independent registered public accounting firm identifies deficiencies in our internal controls that aredeemed to be material weaknesses, the market price of our stock could decline and we could be subject to sanctions or investigations by Nasdaq, the SEC orother regulatory authorities, which would entail expenditure of additional financial and management resources.Item 1B. Unresolved Staff CommentsNone.Item 2. PropertiesOur corporate headquarters, which includes research and development and business operations and executive offices, is located in Emeryville,California. It consists of approximately 22,000 square feet of office and laboratory space under an operating lease that expires in 2022. We also lease limitedoffice space in Maidenhead, United Kingdom under a month-to-month arrangement.We believe that our facilities are adequate to meet our needs for the immediate future, and that, should it be needed, suitable additional space will beavailable to accommodate expansion of our operations.45Table of ContentsItem 3. Legal ProceedingsWe are currently not a party to any material legal proceedings.Item 4. Mine Safety DisclosuresNot Applicable.46Table of ContentsPART IIItem 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity SecuritiesMarket InformationOur common stock has been traded on the Nasdaq Global Market since November 23, 2010 under the symbol “ZGNX.” Prior to such time, there was nopublic market for our common stock. The following table sets forth the high and low sales price of our common stock as reported by the Nasdaq GlobalMarket during each quarter of the two most recent years: High Low2017 Fourth Quarter$43.35 $32.40Third Quarter$37.55 $10.05Second Quarter$15.40 $10.20First Quarter$13.40 $7.702016 Fourth Quarter$13.70 $7.50Third Quarter$11.59 $7.74Second Quarter$11.98 $7.33First Quarter$14.60 $7.90Holders of Common StockAccording to the records of our transfer agent, there were 11 holders of record of our common stock on February 28, 2018. Because many of such sharesare held by brokers and other institutions on behalf of stockholders, we are unable to estimate the total number of stockholders represented by these recordholders.47Table of ContentsPerformance GraphThe following stock performance graph illustrates a comparison of the total cumulative stockholder return on our common stock over the five yearperiod ended December 31, 2017 to the Nasdaq Composite Index and the Nasdaq Biotechnology Index. The graph assumes an initial investment of $100 onDecember 31, 2012, and that all dividends were reinvested. The comparisons in the graph are required by the Securities and Exchange Commission, or SEC,and are not intended to forecast or be indicative of possible future performance of our common stock.Dividend PolicyWe have never declared or paid any cash dividends on our capital stock and do not anticipate paying any cash dividends in the foreseeable future. Weexpect to retain available cash to finance ongoing operations and the potential growth of our business. Any future determination to pay dividends on ourcommon stock will be at the discretion of our board of directors and will depend upon, among other factors, our results of operations, financial condition,capital requirements, contractual restrictions, business prospects and other factors our board of directors may deem relevant.Equity Compensation Plan InformationSee Part III, Item 12, “Security Ownership of Certain Beneficial Owners and Management and related Stockholder Matters” for information regardingsecurities authorized for issuance under equity compensation plans.Recent Sales of Unregistered SecuritiesNone.Issuer Repurchases of Equity SecuritiesNone.48Table of ContentsItem 6. Selected Financial Data.The following table summarizes certain of our selected financial data. The selected statement of operations data for the years ended December 31, 2017,2016 and 2015 and the consolidated balance sheet data as of December 31, 2017 and 2016 should be read in conjunction with the audited financialstatements and related notes, Management’s Discussion and Analysis of Financial Condition and Results of Operations and other financial informationpresented elsewhere in this Form 10-K. The selected statements of operations data for the years ended December 31, 2014 and 2013 and the consolidatedbalance sheet data as of December 31, 2015, 2014 and 2013 have been derived from audited financial statements not included herein.Our historical results for any prior period do not necessarily indicate our results to be expected for any future period. Year Ended December 31, 2017 2016 2015 2014 2013 (In Thousands, Except Per Share Amounts)Statement of Operations Data Revenue: Contract manufacturing revenue (1)$9,821 $28,525 $24,369 $15,392 $—Net product revenue— — — 9,840 31,699Service and other product revenue— 325 2,813 3,715 1,313Total revenue9,821 28,850 27,182 28,947 33,012Operating expenses: Cost of contract manufacturing (1)10,729 22,173 22,356 14,342 —Cost of goods sold— — — 5,263 21,241Royalty expense— 295 345 591 1,242Research and development67,449 41,840 27,860 11,893 8,372Selling, general and administrative25,885 26,996 26,347 34,639 46,218Loss on contract termination478 — — — —Change in fair value of contingent consideration (2)24,100 1,800 (2,000) — —Restructuring costs— — — — 876Asset impairment charges (3)1,116 8,431 — 838 —Net gain on sale of business— — — (79,980) —Total operating expenses (income)129,757 101,535 74,908 (12,414) 77,949(Loss) income from operations(119,936) (72,685) (47,726) 41,361 (44,937)Other income (expense): Interest expense, net(1,554) (2,382) (2,959) (3,070) (6,592)Loss on sale of marketable securities (4)— — (5,746) — —Loss on extinguishment of debt(5)(4,876) — — (1,254) —Change in fair value of common stock warrant liabilities (6)297 5,387 (1,103) 25,332 (21,927)Change in fair value of embedded derivatives— — — (14) 759Other income (expense)47 46 (71) (784) 96Total other (expense) income(6,086) 3,051 (9,879) 20,210 (27,664)(Loss) income from continuing operations before income taxes(126,022) (69,634) (57,605) 61,571 (72,601)Income tax benefit (expense) (7)— 948 15,901 (84) —Net (loss) income from continuing operations$(126,022) $(68,686) $(41,704) $61,487 $(72,601)Net (loss) income from discontinued operations(795) (1,021) 67,848 (52,900) (8,255)Net (loss) income$(126,817) $(69,707) $26,144 $8,587 $(80,856)Net (loss) income per share, continuing operations, basic(8)$(4.62) $(2.77) $(1.94) $3.45 $(5.35)Net (loss) income per share, continuing operations, diluted(8)$(4.62) $(2.77) $(1.94) $3.44 $(5.35)(1)Amounts relate to the Endo Supply agreement, which was terminated in September 2017. See Note 6 to our consolidated financial statements included inthis Form 10-K.49Table of Contents(2)Reflects changes in the estimated fair value of the contingent consideration liability related to potential regulatory and sales-based milestone payments.See Notes 2 and 3 to our consolidated financial statements included in this Form 10-K.(3)Includes the impairment of long-lived assets used in the production of Sumavel DosePro in 2016 and 2017. See Note 6 to our consolidated financialstatements included in this Form 10-K.(4)Represents loss on sale of marketable securities which was received as part of the sales consideration for divesting Zohydro ER business. See Note 5 toour consolidated financial statements included in this Form 10-K.(5)Reflects loss on extinguishment of the a term loan and a working capital advance note payable in 2017 and the early termination of a financingagreement with Healthcare Royalty Partners in 2014.(6)Reflects changes in the estimated fair value of common stock warrant liabilities. See Note 2 to our consolidated financial statements included in thisForm 10-K.(7)Tax benefit in 2015 was related to the sale of Zohydro ER.(8)See Note 2 to our consolidated financial statements included in this Form 10-K for a discussion of the calculation methodology of net (loss) income pershare and the number of shares used in the computation of the net per share amounts. As of December 31, 2017 2016 2015 2014 2013 (In Thousands)Balance Sheet Data: Cash, cash equivalents and marketable securities$293,503 $91,551 $155,349 $42,205 $72,021Working capital283,720 99,604 154,517 33,741 34,981Total assets417,613 231,505 305,822 202,835 108,288Long-term debt, less current portion— 18,824 15,899 21,703 28,802Accumulated deficit(572,040) (445,223) (375,516) (401,660) (410,247)Total stockholders’ equity301,521 120,756 182,760 55,279 18,42650Table of ContentsItem 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations.MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITIONAND RESULTS OF OPERATIONSThe following discussion and analysis of our financial condition and results of operations should be read in conjunction with “Selected FinancialData” and our consolidated financial statements and related notes appearing elsewhere in this Annual Report on Form 10-K. In addition to historicalinformation, this discussion and analysis contains forward-looking statements that involve risks, uncertainties and assumptions. Our actual results maydiffer materially from those anticipated in these forward-looking statements as a result of certain factors, including, but not limited, to those set forth under“Item 1A — Risk Factors” and elsewhere in this Annual Report on Form 10-K.OverviewWe are a pharmaceutical company developing and commercializing innovative central nervous system (“CNS”) therapies for people living withserious and life-threatening rare CNS disorders and medical conditions. Our current primary area of therapeutic focus is rare, or “orphan” childhood-onsetepilepsy disorders.We currently own and control worldwide development and commercialization rights to ZX008, our lead Phase 3 product candidate. ZX008 is low-dose fenfluramine for the treatment of seizures associated with two rare and catastrophic forms of childhood-onset epilepsy: Dravet syndrome and Lennox-Gastaut syndrome (“LGS”).We initiated our Phase 3 clinical trials in North America (Study 1501) in January 2016 and in Europe and Australia in June 2016 (Study 1502). Study1501 and Study 1502 are each identical randomized, double-blind, placebo-controlled studies of ZX008 as adjunctive therapy for patients with uncontrolledseizures who have Dravet syndrome. In January 2017, we announced our plan to report top-line results from Study 1501 and Study 1502 via a prospectivemerged study analysis approach whereby top-line results from the first approximately 120 subjects randomized into either Study 1501 or 1502 would havetheir study results analyzed and be reported initially as “Study 1.” In April 2017, we completed enrollment of Study 1 and, in September 2017, we announcedpositive top-line results for the 119 patients included in the Study 1 Phase 3 trial. The Study 1 trial met its primary objective of demonstrating that ZX008, ata dose of 0.8 mg/kg/day, is superior to placebo as adjunctive therapy in the treatment of Dravet syndrome in children and young adults based on change inthe frequency of convulsive seizures between the 6-week baseline observation period and the 14-week treatment period (p<0.001). In the trial, ZX008 at adose of 0.8 mg/kg/day also demonstrated statistically significant improvements versus placebo in all key secondary measures, including the proportion ofpatients with clinically meaningful reductions in seizure frequency (50% or greater) and longest seizure-free interval. The same analyses comparing a 0.2mg/kg/day ZX008 dose versus placebo also demonstrated statistically significant improvement compared with placebo. ZX008 was generally well toleratedwithout any signs or symptoms of valvulopathy or pulmonary hypertension.In September 2016, we initiated Part 1 of Study 1504, a two-part, double blind, randomized, two arm pivotal Phase 3 clinical trial of ZX008 in Dravetsyndrome patients who are taking stiripentol, valproate and/or clobazam as part of their baseline standard care. Part 1 investigated the pharmacokineticprofile and safety of ZX008 when co-administered with the stiripentol regimen (stiripentol, valproate and clobazam). Based on the results of thepharmacokinetic and safety portion of the trial, in February 2017 we initiated the safety and efficacy portion of Study 1504, a two-arm study that comparesZX008 versus placebo across the titration and 12-week maintenance periods at multiple sites, which currently includes sites in France, the Netherlands,United States, Canada, Germany, the United Kingdom and Spain. Study 1504 is targeted to enroll approximately 40 patients per treatment group. In January2018, we completed enrollment of this study and expect to report top-line results from the trial in the second quarter of 2018. We believe we are on track tosubmit applications for regulatory approvals for ZX008 in the United States and Europe in the fourth quarter of 2018.Beginning in first quarter of 2016, we funded an open-label, dose-finding, investigator-initiated study of the effectiveness and tolerability of ZX008 asan adjunctive therapy in patients with LGS. In December 2016, we presented initial data from an interim analysis of the first 13 patients to have completed atleast 12 weeks of this Phase 2 clinical trial at the 70th Annual Meeting of the American Epilepsy Society. These data demonstrated that ZX008 providedclinically meaningful improvement in major motor seizure frequency in patients with severe refractory LGS, with 7 out of 13 patients (54%) achieving atleast a 50% reduction in the number of major motor seizures, at doses below the 0.8 mg/kg/day maximum allowed dose. In addition, ZX008 was generallywell tolerated without any observed signs or symptoms of valvulopathy or pulmonary hypertension. We believe these data indicate that ZX008 has thepotential to be a safe and effective adjunctive treatment of major motor seizures for patients with LGS. Based on the strength of the LGS data generated, in thefirst quarter of 2017, we submitted an investigational new drug, or IND, application to the FDA to initiate a Phase 3 program of ZX008 in LGS, which becameeffective in April 2017. In November 2017, we announced the initiation of our multicenter global Phase 3 clinical trial of ZX008 as an adjunctive treatmentfor seizures in patients with LGS (Study 1601) with the enrollment of the first patient into51Table of Contentsthe study. In the first half of 2017, ZX008 received orphan drug designation for the treatment of LGS from the FDA in the United States and the EuropeanMedicines Agency (the “EMA”) in the EU.Sale of Sumavel DosePro Business and Termination of the Contract Manufacturing Supply AgreementIn May 2014, we sold our Sumavel DosePro (sumatriptan injection) Needle-free Delivery System business to affiliates of Endo International plc, orEndo. In connection with the sale, we entered into a supply agreement to manufacture and supply Sumavel DosePro to Endo (the “Endo Supply Agreement”).Under this agreement, we provided contract manufacturing services and supplied Sumavel DosePro to Endo through April 2017. In September 2017, theEndo Supply Agreement was terminated and we also terminated our relationships with third party suppliers and manufacturers related to Sumavel DosePro.Sale of Zohydro ER BusinessIn May 2015, we sold our Zohydro ER business to enable us to focus on development of our rare CNS product candidates and to enhance our financialstrength. Zohydro ER (hydrocodone bitartrate) is an extended-release capsule oral formulation of hydrocodone without acetaminophen.Relday™ Development and License Agreement TerminationIn July 2011, we entered into a development and license agreement with Durect Corporation, or Durect, under which we were granted an exclusiveworldwide development and commercialization license to intellectual property related to Relday. Relday was an investigational, proprietary, long-actingformulation of risperidone, an atypical anti-psychotic agent. On August 1, 2017, we and Durect entered into an agreement to terminate the development and license agreement related to Relday. We have nofurther obligations to make any potential future milestone payments with respect to Relday. In addition, the termination agreement does not provide us withany future royalty entitlements.The termination agreements with Durect and Endo related to Relday and Sumavel DosePro, respectively, will enable us to focus our resources on thedevelopment of ZX008, our lead product candidate and we no longer have a source of recurring revenue.Critical Accounting Policies and EstimatesOur management’s discussion and analysis of our financial condition and results of operations is based on our consolidated financial statements, whichhave been prepared in conformity with generally accepted accounting principles in the United States, or GAAP. The preparation of these consolidatedfinancial statements requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, expenses and related disclosures. Weevaluate our estimates and assumptions on an ongoing basis. Our estimates are based on historical experience and various other assumptions that we believeto be reasonable under the circumstances. Actual results could differ from those estimates.We believe that the assumptions and estimates associated with revenue recognition, the impairment assessments related to goodwill, indefinite-livedintangible assets and other long-lived assets, business combinations, discontinued operations, fair value measurements, clinical trials expense accrual andstock-based compensation have the greatest potential impact on our consolidated financial statements. Therefore, we consider these to be our criticalaccounting policies and estimates. For further information on all of our significant accounting policies, see Note 2 to our consolidated financial statementsincluded in this Form 10-K.Revenue RecognitionWe historically generated revenue from contract manufacturing, service fees earned on collaborative arrangements and product revenue related toSumavel DosePro prior to the sale of the business in May 2014. Until April 2017, we generated revenue from the sale of Zohydro ER, which is included in netincome (loss) from discontinued operations in the consolidated statement of operations and comprehensive income (loss). Revenue was recognized when (i)persuasive evidence of an arrangement existed, (ii) delivery had occurred and title had passed, (iii) the price was fixed or determinable and (iv) collectabilitywas reasonably assured. Revenue from sales transactions where the buyer has the right to return the product was recognized at the time of sale only if (a) ourprice to the buyer was substantially fixed or determinable at the date of sale, (b) the buyer had paid us, or the buyer was obligated to pay us and theobligation was not contingent on resale of the product, (c) the buyer’s obligation to us would not be changed in the event of theft or physical destruction ordamage of the product, (d) the buyer acquiring the product for resale had economic substance apart from that provided by us, (e) we did not have significantobligations for future performance to directly bring about resale of the product by the buyer, and (f) the amount of future returns could be reasonablyestimated. We deferred recognition of revenue on product shipments of Zohydro ER until the right of return lapsed, as we were not able to reliably estimateexpected returns of the product at the time of shipment given the limited sales and return history of Zohydro ER.52Table of ContentsRevenue arrangements with multiple elements were divided into separate units of accounting if certain criteria was met, including whether thedelivered element had stand-alone value to the customer. The consideration received was allocated among the separate units based on their respective fairvalues, and the applicable revenue recognition criteria were applied to each of the separate units. The application of the multiple element guidance requiressubjective determinations, and required us to make judgments about the individual deliverables and whether such deliverables were separable from the otheraspects of the contractual relationship. Deliverables were considered separate units of accounting provided that: (1) the delivered item(s) had value to thecustomer on a stand-alone basis and (2) if the arrangement included a general right of return relative to the delivered item(s), delivery or performance of theundelivered item(s) was considered probable and substantially in our control. In determining the units of accounting, we evaluated certain criteria, includingwhether the deliverables have stand-alone value, based on the consideration of the relevant facts and circumstances for each arrangement. In addition, weconsidered whether the buyer could use the other deliverable(s) for their intended purpose without the receipt of the remaining element(s), whether the valueof the deliverable was dependent on the undelivered item(s), and whether there were other vendors that could provide the undelivered element(s).Arrangement consideration that is fixed or determinable was allocated among the separate units of accounting using the relative selling price method,and the applicable revenue recognition criteria, as described above, was applied to each of the separate units of accounting in determining the appropriateperiod or pattern of recognition. We determined the estimated selling price for deliverables within each agreement using vendor-specific objective evidence,or VSOE, of selling price, if available, third-party evidence, or TPE, of selling price if VSOE is not available, or management’s best estimate of selling price(“BESP”) if neither VSOE nor TPE is available. Determining the BESP for a unit of accounting requires significant judgment. In developing the BESP for aunit of accounting, we considered applicable market conditions and relevant entity-specific factors, including factors that were contemplated in negotiatingthe agreement with the customer and estimated costs.Contract Manufacturing RevenueWe recorded deferred revenue when we received payments in advance of the delivery of products or the performance of services. As part of the sale ofour Sumavel DosePro business in May 2014 to Endo, we allocated a portion of the total consideration received as payments in advance of the delivery ofproduct under the Endo Supply Agreement that was concurrently entered into with the asset sale. We initially recorded $9.1 million of deferred revenue,which was being recognized as contract manufacturing revenue when earned on a “proportional performance” basis as product was delivered. As a result, aportion of our contract manufacturing revenue reported included deferred revenue from this transaction being recognized when earned.Under the proportional performance method, revenue recognition is based on products delivered to date relative to the total expected products to bedelivered over the performance period as this is considered to be representative of the delivery of service under the arrangement. Management exercisesjudgment to estimate the total expected products to be delivered under the Endo Supply Agreement and actual results may differ from these estimates. Theperformance period under the Endo Supply Agreement was initially estimated to be 8 years, the minimum contractual term under the agreement. Changes inestimates of total expected products to be delivered or service obligation time period were accounted for prospectively as a change in estimate. In the fourthquarter of 2016, as a result of Endo’s intent to terminate the supply agreement by the first half of 2017, we revised our estimates of total expected products tobe delivered under the arrangement and recognized revenue for the inception-to-date effect of the change in estimate. The effect of this change in estimateresulted in an increase to 2016 revenue by $4.9 million. All remaining deferred revenue related to the Endo Supply Agreement was recognized in 2017.The termination agreements with Durect and Endo related to Relday and Sumavel DosePro, respectively, will enable us to focus our resources on thedevelopment of ZX008, our lead product candidate. As of September 30, 2017, we no longer have a source of recurring revenue. Unless and until we obtainregulatory approval of and commercialize ZX008, our ability to generate any meaningful revenue will be limited.Contingent Consideration Liabilities Resulting from a Business CombinationIn conjunction with our business combination we have recorded contingent consideration liabilities payable upon the achievement of specifieddevelopment, regulatory approval or sales-based milestone events. The contingent consideration liabilities are measured at their respective fair values as ofthe acquisition date. The models used in valuing the contingent consideration liabilities are based on significant unobservable inputs, including but notlimited to:•estimates of revenues related to the products or product candidates;•the probability of success for unapproved product candidates considering their stages of development;•the time to complete the development and approval of product candidates;53Table of Contents•the life of the potential commercialized products and associated risks, including the inherent difficulties and uncertainties in developing a productcandidate such as obtaining FDA and other regulatory approvals;•risks related to the viability of and potential alternative treatments in any future target markets; and•risk adjusted discount rates.We revalue contingent consideration obligations each quarter following the acquisition and record increases or decreases in fair value within thechange in fair value of contingent consideration line item in our consolidated statements of operations.Increases or decreases in the fair value of our contingent consideration liabilities can result from updates to assumptions such as the expected timing orprobability of achieving the specified milestones, changes in projected revenues, changes in time periods to attain events or revenue targets, or changes indiscount rates. Significant judgment is employed in determining these assumptions as of the acquisition date and for each subsequent period. Updates toassumptions could have a significant impact on our results of operations in any given period. Actual results may differ from estimates.We believe the fair values used to record contingent consideration liabilities incurred in connection with the business combination are based uponreasonable estimates and assumptions given the facts and circumstances as of the related valuation dates.Goodwill and Indefinite-Lived Intangible AssetsGoodwill and indefinite-lived intangible assets are reviewed for impairment at least annually in the fourth quarter, and more frequently if events orother changes in circumstances indicate that the carrying amount of the assets may not be recoverable. Impairment of goodwill and indefinite-livedintangibles is determined to exist when the fair value is less than the carrying value of the net assets being tested.GoodwillWe determined that we have only one operating segment and reporting unit. Accordingly, our review of goodwill impairment indicators is performed atthe entity-wide level. In performing each annual impairment assessment and any interim impairment assessment, we determine if we should qualitativelyassess whether it is more likely than not that the fair value goodwill is less than its carrying amount (the qualitative impairment test). Some of the factorsconsidered in the assessment include general macro-economic conditions, conditions specific to the industry and market, cost factors, the overall financialperformance and whether there have been sustained declines in the Company's share price. If we conclude it is more likely than not that the fair value of thereporting unit is less than its carrying amount, or elect not to use the qualitative impairment test, a quantitative impairment test is performed using a two-stepprocess. The first step of the goodwill qualitative impairment assessment compares the fair value of the reporting unit to its carrying value. If the fair value ofthe reporting unit exceeds its carrying amount, goodwill of the reporting unit is considered not impaired, and the second step of the impairment test is notrequired. We use our market capitalization as an indicator of fair value. We believe that since our reporting unit is publicly traded, the ability of a controllingshareholder to benefit from synergies and other intangible assets that arise from control might cause the fair value of our reporting unit as a whole to exceedour market capitalization. However, we believe that the fair value measurement need not be based solely on the quoted market price of an individual share ofour common stock, but also can consider the impact of a control premium in measuring the fair value of its reporting unit. Should our market capitalizationbe less than our total stockholder's equity as of our annual test date or as of any interim impairment testing date, we would also consider market comparables,recent trends in our stock price over a reasonable period and, if appropriate, use an income approach (discounted cash flow) to determine whether the fairvalue of our reporting unit is greater than our carrying amount. If we were to use an income approach, we would establish a fair value by estimating thepresent value of our projected future cash flows expected to be generated from our business. The discount rate applied to the projected future cash flows toarrive at the present value would be intended to reflect all risks of ownership and the associated risks of realizing the stream of projected future cash flows.Our discounted cash flow methodology would consider projections of financial performance for a period of several years combined with an estimated residualvalue. The most significant assumptions we would use in a discounted cash flow methodology are the discount rate, the residual value and expected futurerevenues, gross margins and operating costs, along with considering any implied control premium. The second step, if required, compares the implied fairvalue of the reporting unit goodwill with the carrying amount of that goodwill. If the carrying amount of the reporting unit's goodwill exceeds its implied fairvalue, an impairment charge is recognized in an amount equal to that excess. Implied fair value is the excess of the fair value of the reporting unit over thefair value of all identified assets and liabilities. In 2017, we elected to bypass the qualitative goodwill impairment assessment. As of October 1, 2017, we havedetermined through a quantitative impairment test that the fair value significantly exceeded the carrying value of our single reporting unit, and concludedthat goodwill was not impaired. We did not recognize any goodwill impairment in any of the years presented.54Table of ContentsIndefinite-Lived Intangible AssetOur indefinite-lived intangible asset consists of in-process research and development (“IPR&D”) acquired in a business combination that are used inresearch and development activities but have not yet reached technological feasibility, regardless of whether they have alternative future use. The primarybasis for determining the technological feasibility or completion of these projects is obtaining regulatory approval to market the underlying products in anapplicable geographic region. We classify in-process research and development acquired in a business combination as an indefinite-lived intangible assetuntil the completion or abandonment of the associated research and development efforts. Upon completion of the associated research and developmentefforts, we perform a final test for impairment and will determine the useful life of the technology and begin amortizing the assets to reflect their use over theirremaining lives. Upon permanent abandonment, we would write-off the remaining carrying amount of the associated in-process research and developmentintangible assetIn performing each annual impairment assessment and any interim impairment assessment, we determine if we should qualitatively assess whether it ismore likely than not that the fair value of our IPR&D asset is less than its carrying amount (the qualitative impairment test). If we conclude that is the case, orelect not to use qualitative impairment test, we would proceed with quantitatively determining the fair value of the IPR&D asset and comparing its fair valueto its carrying value to determine the amount of impairment, if any (the quantitative impairment test).In performing the qualitative impairment test, the Company considers the results of the most recent quantitative impairment test and identifies the mostrelevant divers of the fair value for the IPR&D asset. The most relevant drivers of fair value we have identified are consistent with the assumptions used in thequantitative estimate of the IPR&D asset discussed below. Using these drivers, we identify events and circumstances that may have an effect on the fair valueof the IPR&D asset since the last time the IPR&D’s fair value was quantitatively determined. We then weigh these factors to determine and conclude if it isnot more likely than not that the IPR&D asset is impaired. If it is more likely than not that the IPR&D asset is impaired we proceed with quantitativelydetermining the fair value of the IPR&D asset.We use the income approach to determine the fair value of our IPR&D asset. This approach calculates fair value by estimating the after-tax cash flowsattributable to an in-process project over its useful life and then discounting these after-tax cash flows back to a present value. This estimate includessignificant assumptions regarding the estimates that market participants would make in evaluating the IPR&D asset, including the probability of successfullycompleting clinical trials and obtaining regulatory approval to market the IPR&D asset, the timing of and the expected costs to complete IPR&D projects,future net cash flows from potential drug sales, which are based on estimates of the sales price of the drug, the number of patients who will be diagnosed andtreated and our competitive position in the marketplace, and appropriate discount and tax rates. Any impairment to be recorded is calculated as the differencebetween the fair value of the IPR&D asset as of the date of the assessment with the carrying value of the IPR&D asset on our consolidated balance sheet.For 2017, we performed a qualitative test and concluded that it is more-likely-than-not that the fair value of our IPR&D asset exceeded the carryingvalue and no further testing was required. We did not recognize any IPR&D impairment in any of the years presented.For asset purchases outside of business combinations, we expense any purchased research and development assets as of the acquisition date if they haveno alternative future uses.Impairment of Long-Lived AssetsWe evaluate long-lived assets periodically for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset(group) may not be recoverable. An impairment loss would be recognized when the carrying amount of the assets (asset group) exceeds the estimatedundiscounted net cash flows. The amount of the impairment loss to be recorded is calculated as the excess of the carrying value of the assets (asset group)over their fair value.In the fourth quarter of 2016, Endo informed us of their decision to discontinue Sumavel DosePro and we commenced the wind down of ourmanufacturing operations related to the supply of Sumavel DosePro to Endo (see Note 6). As a result, we performed an analysis to estimate cash flows fromproperty and equipment used in the production of Sumavel DosePro in the fourth quarter of 2016. Based on this analysis, we recognized an impairmentcharge for long-lived assets of $6.4 million. In the first quarter of 2017, we recorded an additional asset impairment charge of $0.8 million for long-livedmanufacturing assets associated with the production of Sumavel DosePro. There was no impairment to our long-lived assets in 2015.Discontinued OperationsIn April 2015, we sold the Zohydro ER business. As a result of this sale, our Zohydro ER activity has been excluded from continuing operations for allperiods herein and reported as discontinued operations. See Note 5 to the consolidated financial statements, Sale of Zohydro ER business, for additionalinformation on the divestiture.55Table of ContentsResearch and Development Expense and AccrualsResearch and development costs include personnel-related costs, outside contracted services including clinical trial costs, facilities costs, fees paid toconsultants, milestone payments prior to FDA approval, license fees prior to FDA approval, professional services, travel costs, dues and subscriptions,depreciation and materials used in clinical trials and research and development. Research and development costs are expensed as incurred unless there is analternative future use in other research and development projects. The Company expenses costs relating to the purchase and production of pre-approvalinventories as research and development expense in the period incurred until FDA approval is received.Our expense accruals for clinical trials are based on estimates of the services received from clinical trial investigational sites and contract researchorganizations, or CROs. Payments under some of the contracts we have with such parties depend on factors such as the milestones accomplished, successfulenrollment of certain numbers of patients, site initiation and the completion of clinical trial milestones. In accruing service fees, we estimate the time periodover which services will be performed and the level of effort to be expended in each period. If possible, we obtain information regarding unbilled servicesdirectly from these service providers. However, we may be required to estimate these services based on information available to our product development oradministrative staff. If we underestimate or overestimate the activity associated with a study or service at a given point in time, adjustments to research anddevelopment expenses may be necessary in future periods. Historically, our estimated accrued liabilities have approximated actual expense incurred.Subsequent changes in estimates may result in a material change in our accruals. Payments made prior to the receipt of goods or services to be used inresearch and development are capitalized until the goods or services are received. Such payments are evaluated for current or long term classification basedon when they will be realized.Stock-Based CompensationFor equity awards that vest subject to the satisfaction of service requirements, compensation expense is measured based on the fair value of the awardon the date of grant and is recognized as expense on a straight-line basis over the requisite service period. For stock awards which have a performancecomponent, compensation cost is measured based on the fair value on the grant date (the date performance targets are established) and is expensed over therequisite service period for each separately vesting tranche when achievement of the performance objective becomes probable. We assess the probability ofthe performance objectives being met on a continuous basis.We use a Black-Scholes option-pricing model to determine the fair value of our stock options. This fair value determined using this model is affectedby our stock price, as well as assumptions regarding a number of subjective variables. These variables include the expected stock price volatility over theexpected term of the option, the expected term of the option and the risk-free interest rate associated with the expected term of the option. The expected termof employee options granted is determined using the simplified method (based on the midpoint between the vesting date and the end of the contractual term).We have historically estimated expected volatility based on our own historical volatility supplemented by a review of historical volatilities of industry peers.As sufficient trading history now exists for our common stock, we began estimating expected volatility using only our own historical stock prices in 2017. Ifany of the assumptions used in the Black-Scholes option pricing model change significantly, stock-based compensation expense may differ materially in thefuture from that recorded in the current period.On January 1, 2017, we adopted the Financial Accounting Standards Board's (“FASB”) ASU 2016-09, Compensation Stock Compensation (Topic 718):Improvements to Employee Share-Based Payment Accounting (“ASU 2016-09”). Under ASU 2016-09, entities are permitted to make an accounting policyelection to either estimate forfeitures on share-based payment awards, as previously required, or to recognize forfeitures as they occur. We have elected torecognize forfeitures as they occur. The impact of this change in accounting policy was determined to be insignificant and resulted in no cumulative-effectchange to our retained earnings.We expect to continue to grant stock options and awards in the future, and to the extent that we do, our actual stock-based compensation expenserecognized in future periods will likely increase.Income TaxesWe account for income taxes under the asset and liability method of accounting. We recognize deferred tax assets and liabilities for the future taxconsequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases, aswell as for operating loss and tax credit carryforwards. We measure deferred tax assets and liabilities using enacted tax rates expected to apply to taxableincome in the years in which we expect to recover or settle those temporary differences. We recognize the effect of a change in tax rates on deferred tax assetsand liabilities in the results of operations in the period that includes the enactment date. We reduce the measurement of a deferred tax asset, if necessary, by avaluation allowance if it is more likely than not that we will not realize some or all of the deferred tax asset.56Table of ContentsWe account for uncertain tax positions by recognizing the financial statement effects of a tax position only when, based upon technical merits, it ismore likely than not that the position will be sustained upon examination.Significant judgment is required in determining the accounting for income taxes. In the ordinary course of business, many transactions and calculationsarise where the ultimate tax outcome is uncertain. Our judgments, assumptions and estimates relative to the accounting for income taxes take into accountcurrent tax laws, our interpretation of current tax laws, and possible outcomes of future audits conducted by foreign and domestic tax authorities. Althoughwe believe that our estimates are reasonable, the final tax outcome of matters could be different from our assumptions and estimates used when determiningthe accounting for income taxes. Such differences, if identified in future periods, could have a material effect on the amounts recorded in our consolidatedfinancial statements.On December 22, 2017, the U.S. government enacted comprehensive tax legislation referred to as the Tax Cuts and Jobs Act (the “Tax Act”) whichsignificantly revises the Internal Revenue Code of 1986, as amended, or the IRC. The Tax Act contains, among other things, significant changes to corporatetaxation, including reduction of the corporate tax rate from a top marginal rate of 35% to a flat rate of 21% for tax years beginning after December 31, 2017,limitation of the deduction for net operating losses to 80% of current year taxable income and elimination of net operating loss carrybacks, implementing aterritorial tax system, and requiring a mandatory one-time tax on U.S. owned undistributed foreign earnings and profits known as the transition tax.On December 22, 2017, the SEC staff issued Staff Accounting Bulletin No. 118 (“SAB 118”) that allows us to record provisional amounts during ameasurement period not to extend beyond one year of the enactment date. We are currently analyzing the impact of the various provisions of the 2017 TaxAct. The ultimate impact may differ from the provisional amounts recorded. We expect to complete our analysis within the measurement period in accordancewith SAB 118.Results of OperationsComparison of Years Ended December 31, 2017, 2016 and 2015Revenue Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeContract manufacturing revenue$9,821 $28,525 $24,369 $(18,704) (66)% $4,156 17 %Service and other product revenue— 325 2,813 (325) (100)% (2,488) (88)%Total revenue$9,821 $28,850 $27,182 $(19,029) (66)% $1,668 6 %Upon termination of the Endo Supply Agreement in September 2017, we are now focused on the development of ZX008, our lead product candidate,and we no longer have a source of recurring revenue.The decrease in contract manufacturing revenue in 2017 as compared to 2016 was due to the termination of the Endo Supply Agreement in 2017. Theincrease in contract manufacturing revenue in 2016 as compared to 2015 was primarily due to a change in estimate in the performance period under theproportional performance method. As a result of the impending termination of our contract manufacturing supply agreement with Endo, the performanceperiod and the total expected products to be delivered under the arrangement were revised, which resulted in an increase to 2016 revenue by $4.9 million.Service and other product revenue in 2015 consisted primarily of co-promotion fees earned for our Migranal ® Nasal Spray sales efforts under ouragreement with Valeant Pharmaceuticals North America LLC until it was terminated in June 2015, as well as adjustments to our return reserve for sales ofSumavel DosePro prior to our divestiture in May 2014.Cost of Contract Manufacturing Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeCost of contract manufacturing$10,729 $22,173 $22,356 $(11,444) (52)% $(183) (1)%Cost of contract manufacturing consisted primarily of materials, third-party manufacturing costs, freight in and indirect personnel and other overheadcosts associated with Sumavel DosePro based on units sold to Endo, as well as the effect of changes in reserves for excess, dated or obsolete commercialinventories and production manufacturing variances. It represents the cost of units recognized as contract manufacturing revenues in the period and theimpact of underutilized production capacity and other manufacturing variances. The decrease in cost of manufacturing in 2017 as compared to 2016corresponded to the decrease in revenue in 2017 as compared to 2016. Cost of manufacturing in 2017 included a $2.2 million inventory write-down in thesecond quarter of 2017 to reflect its current net realizable value. Cost of contract manufacturing in 2016 was57Table of Contentsflat compared to 2015 while the corresponding contract manufacturing revenue increased. This was attributable to a change in estimate under theproportional performance method of revenue recognition related to deferred revenue, which had no impact to cost of contract manufacturing.Royalty Expense Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeRoyalty expense$— $295 $345 $(295) (100)% $(50) (14)%Prior to our divestiture of the Sumavel DosePro business in May 2014, we incurred royalty expense on product sales of Sumavel DosePro, either by us orone of our licensees. Royalty expense incurred subsequent to our divestiture represent the amortization of a royalty prepayment over the contractual term tosupply Sumavel DosePro to Endo. In the fourth quarter of 2016, approximately $2.0 million of unamortized prepaid royalties were written off as a result ofthe impending termination of our supply agreement and were included in impairment charges within operating expenses in the consolidated statements ofoperations. Research and Development Expenses Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeResearch and development$67,449 $41,840 $27,860 $25,609 61% $13,980 50%Research and development expenses consist of expenses incurred in developing, testing and seeking marketing approval of our product candidates,including: license and milestone payments; payments made to third-party clinical research organizations, or CROs, and investigational sites, which conductour clinical trials on our behalf, and consultants; expenses associated with regulatory submissions, pre-clinical development and clinical trials; payments tothird-party manufacturers, which produce our active pharmaceutical ingredient and finished product; personnel related expenses, such as salaries, benefits,travel and other related expenses, including stock-based compensation; and facility, maintenance, depreciation and other related expenses.We utilize contract manufacturing organizations, CROs, contract laboratories and independent contractors to produce product candidate material andfor the conduct of our pre-clinical studies and clinical trials. We track third-party costs by program. We recognize the expenses associated with the servicesprovided by CROs based on estimated progress toward completion at the end of each reporting period. We coordinate clinical trials through a number ofcontracted investigational sites and recognize the associated expense based on a number of factors, including actual and estimated subject enrollment andvisits, direct pass-through costs and other clinical site fees. The table below sets forth information regarding our research and development costs for our majordevelopment programs.The table below sets forth information regarding our research and development costs for our major development programs. Year Ended December 31, 2017 2016 2015 (In Thousands)Research and development expenses: ZX008$47,819 $29,133 $10,782Relday (1)40 439 9,625Other (2)19,590 12,268 7,453Total$67,449 $41,840 $27,860(1)In August 2017, we and Durect entered into an agreement to terminate the development and license agreement related to Relday. (2)Other research and development expenses include employee and infrastructure resources that are not tracked on a program-by-program basis.The increase in ZX008 expense in 2017 as compared to 2016 was attributable to the progression and expansion of our clinical trial activities related toour Phase 3 development program of ZX008 in Dravet syndrome. The increase in ZX00858Table of Contentsexpense in 2016 as compared to 2015 was primarily attributable to increased development activities related to our Phase 3 clinical trials in Dravet syndromeand funding of an open-label dose-ranging investigator-initiated study in patients with LGS. In addition, 2016 research and development expense included a$1.5 million asset acquisition for a project that had not yet reached technological feasibility, was deemed to have no alternative use, and was immediatelyexpensed.We use our employee and infrastructure resources across our product and product candidate development programs. Therefore, we have not trackedsalaries, other personnel related expenses, facilities or other related costs to our product development activities on a program-by-program basis.We anticipate research and development expenses in 2018 to increase over our 2017 levels as we continue to further develop Phase 3 studies of ZX008in Dravet syndrome and continue the planned clinical development activities with respect to our Phase 3 clinical trial of ZX008 in LGS for which we enrolledour first patient into the study in November 2017.Selling, General and Administrative Expenses Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeSelling expense$4,762 $6,002 $3,935 $(1,240) (21)% $2,067 53 %General and administrative expense21,123 20,994 22,412 129 1 % (1,418) (6)%Total$25,885 $26,996 $26,347 $(1,111) (4)% $649 2 %Selling expense consists primarily of salaries and benefits of marketing personnel, marketing and advertising costs, service fees under our co-promotionagreement and product sample costs. The decrease in selling expense in 2017 as compared to 2016 reflected lower spend on market research activities relatedto ZX008. The increase in selling expense in 2016 as compared to 2015 resulted from our increased spend on marketing infrastructure, marketing researchand participation in industry conferences raising awareness of our lead product candidate ZX008 and its potential to treat LGS.General and administrative expenses consist primarily of salaries and related costs for personnel in executive, finance, accounting, businessdevelopment and internal support functions. In addition, general and administrative expenses include professional fees for legal, public relations, patentprotection, tax and accounting services.General and administrative expense remained flat in 2017 as compared to 2016. The decrease in general and administrative expense in 2016 ascompared to 2015 was primarily attributable to lower personnel-related expense due to reduced headcount.Change in Fair Value of Contingent Consideration and Asset Impairment Charges Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeChange in fair value of contingentconsideration$24,100 $1,800 (2,000) $22,300 1,239 % $3,800 190%Asset impairment charges$1,116 $8,431 — $(7,315) (87)% $8,431 100%The contingent consideration liability resulted from our acquisition of Zogenix International Limited in October 2014 where we agreed to payadditional consideration if certain future regulatory and commercial milestones are met for ZX008. The increase in the fair value of the contingentconsideration payable in 2017 as compared to 2016 was attributable to a change in the estimated probabilities of achieving the developmental and sales-based milestones to reflect our recently announced positive top-line results from our Phase 3 clinical trial in Dravet syndrome (Study 1) in September 2017,and the initiation of our Phase 3 clinical trial in LGS in November 2017.Asset impairment charges incurred in 2017 and 2016 were primarily associated with long-lived assets used in the production of Sumavel DosePro dueto Endo’s intention to discontinue Sumavel DosePro and associated termination of the Endo Supply Agreement (See Note 6 to the consolidated financialstatements).59Table of ContentsOther income (expense) Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % change Interest income$1,090 $443 $101 $647 146 % $342 339 %Interest expense$(2,644) $(2,825) $(3,060) $181 (6)% $235 (8)%Loss on sale of marketable securities$— $— $(5,746) $— — % $5,746 (100)%Loss on extinguishment of debt$(4,876) $— $— $(4,876) (100)% $— — %Change in fair value of warrantliabilities$297 $5,387 $(1,103) $(5,090) (94)% $6,490 588 %Other income (expense)$47 $46 $(71) $1 2 % $117 165 %Total other income (expense)$(6,086) $3,051 $(9,879) $(9,137) (150)% $12,930 131 %Interest IncomeInterest income increased in 2017 as compared to 2016 and was attributable to interest earned from higher average cash and cash equivalents balancesresulting from our capital raising activities. Interest income increased in 2016 as compared to 2015 and was attributable to interest earned from higheraverage cash and cash equivalents balances resulting from proceeds received for our Zohydro business divestiture in April 2015 and our common stockoffering in August 2015.Interest Expense Interest expense incurred in 2017 and 2016 were primarily attributable to our term debt and amortization of imputed interest on our interest-freeworking capital advance from Endo. In 2017, we settled fully the balance of the working capital advance note payable to Endo in September 2017 and repaidin full borrowings (the “Term Loan”) under a Loan and Security Agreement (the “Loan Agreement”) with Oxford Finance LLC (“Oxford”) and Silicon ValleyBank (“SVB”) (collectively, the “Lenders”) in December 2017. In 2016, we refinanced our term debt and extended its maturity from its original maturity dateof December 1, 2018 to July 1, 2020. In 2015, interest expense incurred was attributable to our term debt, working capital advance from Endo, as well as ourrevolving line of credit for a portion of the year.Loss on sale of marketable securitiesIn 2015, we incurred a loss on sale of marketable securities, which we received as part of the sales consideration related to the divestiture of ourZohydro ER business in 2015.Loss on Extinguishment of DebtIn connection with the termination of the Endo Supply Agreement in September 2017, the interest-free working capital advance of $7.0 millionprovided by Endo in May 2014 to support our Sumavel DosePro contract manufacturing operations became due and payable in accordance with its terms andwas settled in full. We recognized a non-cash charge upon debt extinguishment of $3.4 million to write off the remaining unamortized debt discount. InDecember 2017, we used a portion of the proceeds from our October 2017 common stock offering and repaid the entire $20.0 million Term Loan. Werecognized a $1.5 million loss on the early extinguishment of debt consisting of a non-cash charge to write off the remaining unamortized debt issuance costsand debt discount associated with the warrant issued at loan origination. We also paid $1.9 million in additional fees for prepayment and termination of theLoan Agreement.Change in Fair Value of Common Stock Warrant LiabilitiesThe change in fair value of common stock warrant liabilities resulted from the periodic remeasurement of the estimated fair value (see Note 2 to ourconsolidated financial statements for additional discussion). The decrease in fair value of common stock warrant liabilities in 2017 as compared to 2016 wasdue to the expiration of outstanding warrants exercisable for 1,901,918 shares of common stock with an exercise price of $20.00 per share in July 2017. Thewarrants were issued in connection with a 2012 common stock public offering. As of December 31, 2017, we had outstanding warrants to purchase upto 28,125 shares of common stock at an exercise price of $72.00 per share subject to periodic remeasurement. These warrants will expire in July 2021 if notexercised.60Table of ContentsUK Research and Development CreditsWe carry out extensive research and development activities that may benefit from the UK’s small and medium-sized enterprise (“SME”) research anddevelopment tax credit regime, whereby we may either receive an enhanced UK tax deduction on our research and development activities or a refundablecash credit. Where an entity is in a net operating loss position under the SME regime, it can surrender a portion of the losses that arise from its research anddevelopment activities in return for a refundable cash credit. These refundable cash credits, which may be received without regard to actual tax liability, arenot subject to accounting for income taxes and will be recorded as a component of other income if realized. As of December 31, 2017, we have filed a claimfor a refundable cash credit for our 2015 tax year of up to $3.1 million. We have not recorded a receivable for this refundable cash credit at December 31,2017 as collectability was deemed not probable or reasonably assured.Other Income (Expense)Other income (expense) was comprised primarily of foreign currency transaction gains and losses.Income Taxes Year Ended December 31, 2016 to 2017 2015 to 2016(Dollars in thousands)2017 2016 2015 $ change % change $ change % changeIncome tax benefit$— $948 $15,901 $(948) (100)% $(14,953) (94)%We are required to allocate the provision for income taxes between continuing operations and other categories of earnings, such as discontinuedoperations. We did not record a provision or benefit for income taxes in 2017 as we incurred a net operating loss. In 2016, we recognized a tax benefit tocontinuing operations primarily related to the tax rate reductions enacted in the United Kingdom in September 2016 which resulted in a decrease in ourdeferred tax liability. In 2015, we recognized net income from discontinued operations, and, as a result, we recorded a tax expense of $14.1 million indiscontinued operations and a corresponding tax benefit from continuing operations. The remaining tax benefit to continuing operations primarily relates totax rate reductions enacted in the United Kingdom in November 2015 which resulted in a decrease in our deferred tax liability.Discontinued OperationsIn 2015, we divested our Zohydro ER business. The divestiture qualified for discontinued operations presentation. Accordingly, financial results fromour Zohydro ER business in 2015, including the related gain on the transaction, have been included in net income from discontinued operations (see Note 5to our consolidated financial statements).Net Operating Loss and Tax Credit CarryforwardsAs of December 31, 2017, we had available federal, California and foreign net operating loss carryforwards of approximately $254.4 million, $192.6million and $135.7 million, respectively. If not utilized, the net operating loss carryforwards will begin expiring in 2026 for federal tax purposes and 2016 forstate tax purposes. As of December 31, 2017, we had federal and state research and development tax credit carryforwards of approximately $3.3 million and$4.0 million, respectively. If not utilized, the federal research and development income tax credit carryforwards will begin to expire in 2026. The Californiaresearch and development income tax credit carryforwards do not expire and can be carried forward indefinitely.Under the Tax Act, federal net operating losses arising after December 31, 2017 may be carried forward indefinitely. However, net operating lossesarising after December 31, 2017 will be limited to 80% of taxable income. Our net operating losses generated in 2017 and in prior years will not be subject tothe limitations under the Tax Act.Under Section 382 of the IRC, substantial changes in our ownership may limit the amount of net operating loss and research and development incometax credit carryforwards that could be utilized annually in the future to offset taxable income. Specifically, this limitation may arise in the event of acumulative change in ownership of our company of more than 50% within a three-year period. Any such annual limitation may significantly reduce theutilization of the net operating loss carryforwards before they expire.We are in the process of completing an analysis under Internal Revenue Service Code (“IRC”) Sections 382 and 383 to determine if our net operatingloss carryforwards and research and development credits are limited due to a change in ownership. As of December 31, 2017, we have experienced at leastthree ownership changes. The first ownership change occurred in August 2006 upon the issuance of our Series A-1 convertible preferred stock. As a result ofthis ownership change, we reduced our net operating loss carryforwards by $1.9 million and research and development income tax credits by $8,000. Wedetermined that we had a second ownership change, as defined by IRC Section 382 and 383, which occurred in September61Table of Contents2011 upon the issuance of stock in our follow-on offering. As a result of this second ownership change, we reduced our federal net operating losscarryforwards as of December 31, 2011 by $121.1 million and research and development income tax credits as of December 31, 2011 by $3.0 million. Wealso reduced our California net operating loss carryforwards as of December 31, 2011 by $53.3 million as a result of the second ownership change. We had athird ownership change as defined by IRC Sections 382 and 383, which occurred in January 2014. There was no forfeiture in federal and California netoperating loss carryforwards or research and development income tax credits as a result of the third ownership change.LIQUIDITY AND CAPITAL RESOURCESWe have experienced significant net losses and negative cash flow from operations since inception. We expect to continue to incur net losses andnegative cash flow from operating activities for at least the next year primarily as a result of the expenses incurred in connection with the clinicaldevelopment of ZX008.Since we commenced operations in 2006, our operations have been financed primarily through equity and debt financings and proceeds from twobusiness divestitures—Sumavel DosePro and Zohydro ER. Excluding gains from business divestitures, we have incurred significant net losses fromoperations and negative cash flows from operating activities. As of December 31, 2017, we have an accumulated deficit of $572.0 million. In September2017, our only revenue generating contract was terminated. As a result, we currently do not engage in any revenue-generating activities. We do not knowwhen, or if, we will generate any revenue from product sales and do not expect to generate significant revenue from product sales unless and until wecommercialize ZX008. As of December 31, 2017, we had cash and cash equivalents of $293.5 million.Sources of LiquidityIn May 2016, we entered into an at-the-market sales agreement (the “ATM Agreement”) with Cantor Fitzgerald & Co. (“Cantor”) and filed a registrationstatement (File No. 333-211265) and a prospectus for the offer and sale of up to $25.0 million of shares of our common stock from time to time. In August andSeptember 2017, we sold a total of 1,550,880 shares of our common stock under the ATM Agreement resulting in net proceeds of approximately $19.4million, after deducting underwriting discounts and commissions and other offering expenses. In December 2017, we filed a prospectus supplement under ourshelf registration statement (File No. 333-220759), for the offer and sale of up to $75.0 million of shares of our common stock from time to time pursuant tothe ATM Agreement. Cantor is entitled to a commission at a fixed commission rate of up to 3.0% of the gross proceeds of the sales price of all common stocksold under the ATM Agreement. We and Cantor may each terminate the ATM Agreement at any time upon ten days’ prior notice. To date, we have not soldany shares of common stock under the 2017 prospectus supplement pursuant to the ATM Agreement.In October 2017, we completed an underwritten public offering of 7.7 million shares of our common stock, which included 1.0 million shares ofcommon stock issued upon the exercise in full of the option to purchase additional shares granted to the underwriters in the offering. The shares were sold tothe public at an offering price of $37.50 per share. Net proceeds raised from the offering amounted to approximately $271.3 million, after deductingunderwriting discounts and commissions and other offering expenses.A summary of our cash flow activity was as follows: Year Ended December 31, 2017 2016 2015 (In Thousands)Cash provided by (used in): Operating activities$(75,874) $(72,880) $(64,602)Investing activities(76) 9,899 85,545Financing activities277,902 (817) 92,201Net increase (decrease) in cash and cash equivalents$201,952 $(63,798) $113,144Operating Activities Net cash used in operating activities of $75.9 million in 2017 was primarily attributable to a net loss of $126.8 million, offset by non-cash charges of$39.5 million and a net cash inflow from changes in operating assets and liabilities of $11.4 million. Non-cash charges primarily consisted of a $24.1 millionchange in fair value of contingent consideration, $6.2 million of stock-based compensation, a $4.9 million loss on extinguishment of debt and $3.3 millionof inventory write-down and impairment charges for long-lived assets related to our Endo Supply Agreement. The increase in cash provided by operatingassets and liabilities was primarily attributable to cash received from Endo for previously delivered product. Certain working62Table of Contentscapital balances which were net settled by the extinguishment of the working capital advance note payable pursuant to the Endo termination agreement wereaccounted for as a non-cash activity.Net cash used in operating activities of $72.9 million in 2016 was primarily attributable to a net loss of $69.7 million, offset by non-cash chargesincluding a $8.4 million impairment charge related to long-lived assets associated with the production of Sumavel DosePro and the write-down of prepaidroyalties (see Note 6), $7.4 million of stock based compensation and $1.8 million increase in the fair value of contingent consideration offset by $5.4million change in fair value of warrant liabilities. The primary use of cash from changes in working capital was attributable to an $11.2 million increase intrade accounts receivable due to the timing of shipments and collections. Other uses of cash in operating activities include personnel-related costs, researchand development costs for ZX008, other professional services, including legal and accounting, and increases in our accounts payable and accrued expensesdue to the timing of payments. Cash provided by changes in working capital items was primarily attributable to lower inventory purchases of SumavelDosePro raw materials due to the anticipated wind down of our manufacturing operations related to the supply of Sumavel DosePro to Endo (see Note 6).Net cash used in operating activities of $64.6 million in 2015 was primarily attributable to the use of cash to fund operating expenses, adjusted for non-cash charges including the $89.5 million pre-tax gain on the sale of our Zohydro ER business, a $5.7 million loss on our sale of marketable securities,recognition of $8.5 million of deferred revenue and $7.7 million in stock-based compensation. Significant working capital uses of cash included personnel-related costs, research and development costs (primarily for ZX008 and Relday), other professional services, including legal and accounting, and reduction ofour accounts payable and accrued expense balances totaling $14.4 million, offset by lower accounts receivable balances of $7.5 million.Investing ActivitiesNet cash used in investing activities in 2017 was primarily related to purchases of computer equipment.Net cash provided by investing activities of $9.9 million in 2016 was primarily due to receipt of funds previously held in escrow related to the sale ofour Zohydro ER business.Net cash provided by investing activities of $85.5 million in 2015 was primarily attributable to the proceeds from the sale of our Zohydro ER business.Financing Activities Net cash provided by financing activities of $277.9 million in 2017 consisted of net proceeds of $271.3 million and $19.4 million from our commonstock offering and common stock sale under an at-the-market sales agreement, respectively, and $9.2 million in proceeds from common stock issuancepursuant to our equity incentive plans, offset by $21.9 million to repay all outstanding principal and debt extinguishment costs under our Term Loan withOxford and SVB.Net cash used in financing activities of $0.8 million in 2016 consisted of $1.2 million for net debt repayment, offset by $0.3 million of cash receiptsfrom exercises of employee stock options and employee stock purchase plan.Net cash provided by financing activities was $92.2 million in 2015. The primary inflows of cash associated with financing activities were net proceedsfrom our public offering of $92.2 million and $1.4 million of cash receipts from exercises of employee stock options and employee stock purchase plan. Theprimary outflow of cash associated with financing activities was $1.4 million for the repayment of all outstanding indebtedness under the revolving creditfacility with Oxford and SVB.Future Funding RequirementsOur principal uses of cash are research and development expenses, selling, general and administrative expenses and other working capitalrequirements. Our future funding requirements will depend on many factors, including, but not limited to:•the rate of progress and cost of our clinical trials and other product development programs for our product candidates and any future productcandidates that we may develop, in-license or acquire;•the timing of regulatory approval for any of our product candidates and the commercial success of any approved products;•the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights associated with our productcandidates;•the costs of establishing or outsourcing sales, marketing and distribution capabilities, should we elect to do so;•the costs, terms and timing of completion of outsourced commercial manufacturing supply arrangements for any product candidate;•the effect of competing technological and market developments; and63Table of Contents•the terms and timing of any additional collaborative, licensing, co-promotion or other arrangements that we may establish, including our ability tosecure a global strategic development and commercialization partner for ZX008.Until we can generate a sufficient amount of product revenue and cash flow from operations and achieve profitability, we expect to finance future cashneeds through public or private equity offerings, debt financings, receivables financings or corporate collaboration and licensing arrangements. We cannotbe certain that additional funding will be available on acceptable terms, or at all. If we are unsuccessful in raising additional funds when needed, we may berequired to significantly delay, reduce the scope of or eliminate one or more of our development programs or our commercialization efforts, or ceaseoperating as a going concern. We also may be required to relinquish, license or otherwise dispose of rights to product candidates or products that we wouldotherwise seek to develop or commercialize ourselves on terms that are less favorable than might otherwise be available. If we raise additional funds byissuing equity securities, substantial dilution to existing stockholders would likely result. If we raise additional funds by incurring debt financing, the termsof the debt may involve significant cash payment obligations as well as covenants and specific financial ratios that may restrict our ability to operate ourbusiness. If we are unable to maintain sufficient financial resources, including by raising additional funds when needed, our business, financial condition andresults of operations will be materially and adversely affected and we may be unable to continue as a going concern.Debt ObligationsAs of December 31, 2017, we have fully repaid our Term Loan and working capital advance note payable and have no outstanding indebtedness.Early Extinguishment of Term LoanIn December 2014, we entered into the Loan Agreement with the Lenders, under which we borrowed a $20.0 million Term Loan. In addition, the LoanAgreement provided for a revolving credit facility of up to $4.0 million.In connection with the Loan Agreement, the Lenders were issued warrants to purchase 63,559 shares of the Company’s common stock at an exerciseprice per share of $9.44. The warrants have a term of 10 years from the issuance date. The fair value of the warrants at issuance was estimated to be $0.6million using the Black-Scholes valuation model and was recorded as debt discount to the Term Loan with a corresponding increase to additional paid incapital in the consolidated balance sheet.The Term Loan bore interest at an annual rate equal to the greater of (i) 8.75% or (ii) the sum of the prime rate plus 5.25%. Payments under the TermLoan were interest-only until January 1, 2016, followed by equal monthly payments of principal and interest through the scheduled maturity date ofDecember 1, 2018.In April 2015, in connection with the sale of the Zohydro ER business, we and the Lenders entered into an amendment to the Loan Agreement, whichterminated all encumbrances on our personal property related to our Zohydro ER business.In June 2016, we entered into a second amendment to the Loan Agreement, which modified the loan repayment terms to be interest-only from July 1,2016 to February 1, 2018, followed by equal monthly payments of principal and interest through the new maturity date of July 1, 2020. Under the terms ofthe second amendment, the interest rate applicable to the Term Loan bore interest at an annual rate equal to the greater of (i) 7.00% or (ii) the sum of theprime rate plus 3.25%. In addition, the second amendment terminated the revolving credit facility previously available under the Loan Agreement. Inconnection with the second amendment, we paid (i) an end of term fee of $1.0 million due under the Loan Agreement as a result of this refinancing and (ii)the end of term fee of $0.1 million with respect to the termination of the revolving credit facility. The second amendment also included an end of term feeof $1.4 million payable on July 1, 2020, or upon early repayment of the Term Loan. An early repayment would be subject to a prepayment fee.In December 2017, we used a portion of the proceeds from the Company’s October 2017 common stock offering and repaid in full the entire $20.0million of outstanding principal under the Loan Agreement, plus accrued interest. We recognized a $1.5 million loss on early extinguishment of debtconsisting of a non-cash charge to write off the remaining unamortized debt issuance costs and debt discount associated with the warrant issued at loanorigination. We also paid $1.9 million in additional fees for prepayment and termination of the Loan Agreement.Extinguishment of Working Capital Advance Note PayableIn connection with entering into Endo Supply Agreement in May 2014, Endo provided us with an interest-free working capital advance of $7.0 millionin the form of a note payable to support our DosePro operations. The note payable matures in the event the Endo Supply Agreement is terminated. The notepayable was initially recorded on the consolidated balance sheet net of a $4.7 million debt discount related to imputed interest. The debt discount was beingamortized as interest expense using the effective interest method over the Endo Supply Agreement’s initial term of 8 years.In September 2017, the Company and Endo terminated the supply agreement and the note payable became due and payable in accordance with itsterms. Pursuant to the termination agreement, the $7.0 million promissory note was extinguished64Table of Contentsto settle amounts owed to us for accounts receivable and purchased raw materials. In connection with the extinguishment, the Company recorded a non-cashcharge upon extinguishment of debt of $3.4 million due to the write-off of unamortized discount related to the remaining unamortized imputed interest.Contractual Obligations and CommitmentsThe following table describes our contractual obligations and commitments as of December 31, 2017: Payments due by period Total Less than1 year 1-3 years 4-5 years More than 5 years (In Thousands)Operating lease obligations (1)$5,811 $1,396 $2,465 $1,950 $—(1)Represents the minimum lease payments, net of sublease income from our former headquarters of $1.2 million.In connection with our acquisition of ZX008, we may be required to make certain regulatory and sales-based milestone payments. We cannot, at thistime, determine when or if the related milestones will be achieved or whether the events triggering the commencement of payment obligations will occur.Therefore, such payments were not included in the table above. See Note 3 to our consolidated financial statements in this Form 10-K for additional details ofour potential milestone payment obligations.Recent Accounting PronouncementsFor the summary of recent accounting pronouncements applicable to our consolidated financial statements, see Note 2, Summary of SignificantAccounting Policies, in Part IV, Item 15, Notes to Consolidated Financial Statements, which is incorporated herein by reference.Off-Balance Sheet ArrangementsWe have not engaged in any off-balance sheet arrangements, as defined in Item 303(a)(4)(ii) of Regulation S-KItem 7A. Quantitative and Qualitative Disclosures About Market RiskInterest Rate RiskAs of December 31, 2017, we had cash and cash equivalents of $293.5 million. A portion of our cash equivalents, which are in money market funds,may be subject to interest rate risk and could fall in value if market interest rates increase. However, because our cash equivalents are primarily short-term induration, we believe that our exposure to interest rate risk is not significant and a 100 basis points movement in market interest rates would not have asignificant impact on the total value of our portfolio.Foreign Exchange RiskOur material suppliers and contract manufacturers are primarily located in Euro Zone countries and in the U.K., which requires payments denominatedin the Euro and the British Pound Sterling, respectively. As a result, we face foreign exchange risk for such expenditures. Due to the uncertain timing ofexpected payment in foreign currencies, we do not utilize any forward exchange contracts. While we have not experienced significant gains and/or lossesfrom such transactions to date, an adverse movement in foreign exchange rates could have a material effect on payments made to foreign suppliers andcontract manufacturers in the future. In 2017, the effect of foreign exchange rate fluctuations was not material to our consolidated financial statements. Ahypothetical 10% change in the average exchange rate of the Euro or the British Pound Sterling during 2017 would not have had a material impact on ourconsolidated financial statements. We will continue to monitor and evaluate various options to mitigate the foreign exchange risk as a result of entering intotransactions denominated in currencies other than the U.S. Dollar.Item 8. Financial Statements and Supplementary DataOur consolidated financial statements and the report of our independent registered public accounting firm are included in this report on pages F-1through F-31.Item 9. Changes in and Disagreements with Accountants on Accounting and Financial DisclosureNone.65Table of ContentsItem 9A. Controls and ProceduresConclusions Regarding the Effectiveness of Disclosure Controls and ProceduresWe maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our Exchange Act reports isrecorded, processed, summarized and reported within the timelines specified in the SEC’s rules and forms, and that such information is accumulated andcommunicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regardingrequired disclosure. In designing and evaluating the disclosure controls and procedures, management recognized that any controls and procedures, no matterhow well designed and operated, can only provide reasonable assurance of achieving the desired control objectives, and in reaching a reasonable level ofassurance, management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures.As required by SEC Rule 13a-15(b), we carried out an evaluation, under the supervision and with the participation of our management, including ourChief Executive Officer and Chief Financial Officer, of the effectiveness of the design and operation of our disclosure controls and procedures, as of the endof the period covered by this report. Based on the foregoing, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controlsand procedures were effective as of December 31, 2017 at the reasonable assurance level.Changes in Internal Control Over Financial ReportingThere have been no changes in our internal control over financial reporting during our most recent fiscal quarter that have materially affected, or arereasonably likely to materially affect, our internal control over financial reporting.Management’s Annual Report on Internal Control Over Financial ReportingInternal control over financial reporting refers to the process designed by, or under the supervision of, our Chief Executive Officer and Chief FinancialOfficer, and effected by our board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financialreporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles, and includes thosepolicies and procedures that: (1) pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositionsof our assets; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance withgenerally accepted accounting principles, and that our receipts and expenditures are being made only in accordance with authorizations of our managementand directors; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the company’sassets that could have a material effect on the financial statements.Internal control over financial reporting cannot provide absolute assurance of achieving financial reporting objectives because of its inherentlimitations. Internal control over financial reporting is a process that involves human diligence and compliance and is subject to lapses in judgment andbreakdowns resulting from human failures. Internal control over financial reporting also can be circumvented by collusion or improper management override.Because of such limitations, there is a risk that material misstatements may not be prevented or detected on a timely basis by internal control over financialreporting. However, these inherent limitations are known features of the financial reporting process. Therefore, it is possible to design into the processsafeguards to reduce, though not eliminate, this risk.Management is responsible for establishing and maintaining adequate internal control over our financial reporting, as such term is defined in Rule 13a-15(f) under the Exchange Act. Under the supervision and with the participation of our management, including our Chief Executive Officer and ChiefFinancial Officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting. Management has used the framework setforth in the report entitled “Internal Control — Integrated Framework (2013)” published by the Committee of Sponsoring Organizations of the TreadwayCommission to evaluate the effectiveness of our internal control over financial reporting. Based on this evaluation, management has concluded that ourinternal control over financial reporting was effective as of December 31, 2017, the end of our most recent fiscal year. Pursuant to Section 404(c) of theSarbanes-Oxley Act, our independent registered public accounting firm has issued an attestation report on the effectiveness of our internal control overfinancial reporting for the year ended December 31, 2017, which is included below.66Table of Contents Report of Independent Registered Public Accounting FirmTo the Shareholders and the Board of Directors of Zogenix, Inc.Opinion on Internal Control over Financial ReportingWe have audited Zogenix, Inc.’s internal control over financial reporting as of December 31, 2017, based on criteria established in Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) (“the COSO criteria”). In ouropinion, Zogenix, Inc. (“the Company”) maintained, in all material respects, effective internal control over financial reporting as of December 31, 2017,based on the COSO criteria.We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (“PCAOB”), theconsolidated balance sheets of the Company as of December 31, 2017 and December 31, 2016, the related consolidated statements of operations,comprehensive (loss) income, stockholders’ equity, and cash flows, for each of the three years in the period ended December 31, 2017, and the related notesand our report dated March 6, 2018 expressed an unqualified opinion thereon.Basis for OpinionThe Company’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of theeffectiveness of internal control over financial reporting included in the accompanying Management's Annual Report on Internal Control Over FinancialReporting. Our responsibility is to express an opinion on the Company’s internal control over financial reporting based on our audit. We are a publicaccounting firm registered with the PCAOB and are required to be independent with respect to the Company in accordance with the U.S. federal securitieslaws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtainreasonable assurance about whether effective internal control over financial reporting was maintained in all material respects.Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testingand evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considerednecessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.Definition and Limitations of Internal Control Over Financial ReportingA company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financialreporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’sinternal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail,accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded asnecessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of thecompany are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assuranceregarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on thefinancial statements.Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of anyevaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degreeof compliance with the policies or procedures may deteriorate./s/ Ernst & Young LLPRedwood City, CaliforniaMarch 6, 201867Table of ContentsItem 9B. Other InformationNone.68Table of ContentsPART IIIItem 10. Directors, Executive Officers and Corporate GovernanceInformation required by this item will be contained in our Definitive Proxy Statement to be filed with the Securities and Exchange Commission inconnection with our 2018 Annual Meeting of Stockholders, which is expected to be filed not later than 120 days after the end of our fiscal year endedDecember 31, 2017, under the headings “Election of Directors,” “Corporate Governance and Other Matters ,” “Executive Officers,” and “Section 16(a)Beneficial Ownership Reporting Compliance,” and is incorporated herein by reference .We have adopted a Code of Business Conduct and Ethics that applies to our officers, directors and employees which is available on our internetwebsite at www.zogenix.com. The Code of Business Conduct and Ethics contains general guidelines for conducting the business of our company consistentwith the highest standards of business ethics, and is intended to qualify as a “code of ethics” within the meaning of Section 406 of the Sarbanes-Oxley Act of2002 and Item 406 of Regulation S-K. In addition, we intend to promptly disclose (1) the nature of any amendment to our Code of Business Conduct andEthics that applies to our principal executive officer, principal financial officer, principal accounting officer or controller or persons performing similarfunctions and (2) the nature of any waiver, including an implicit waiver, from a provision of our code of ethics that is granted to one of these specifiedofficers, the name of such person who is granted the waiver and the date of the waiver on our website in the future.Item 11. Executive CompensationInformation required by this item will be contained in our Definitive Proxy Statement under the heading “Executive Compensation and OtherInformation” and is incorporated herein by reference.Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder MattersInformation required by this item will be contained in our Definitive Proxy Statement under the headings “Security Ownership of Certain BeneficialOwners and Management” and is incorporated herein by reference.Item 13. Certain Relationships, Related Transactions and Director IndependenceInformation required by this item will be contained in our Definitive Proxy Statement under the headings “Certain Relationships and Related PartyTransactions” and “Independence of the Board of Directors” and is incorporated herein by reference.Item 14. Principal Accounting Fees and ServicesInformation required by this item will be contained in our Definitive Proxy Statement under the heading “Independent Registered Public AccountingFirm’s Fees” and is incorporated herein by reference.69Table of ContentsPART IVItem 15. Exhibits, Financial Statement Schedules(a) Documents filed as part of this report.1. Financial Statements. The following consolidated financial statements of Zogenix, Inc., together with the report thereon of Ernst & Young LLP, anindependent registered public accounting firm, are included in this Annual Report on Form 10-K: PageReport of Independent Registered Public Accounting FirmF- 2Consolidated Balance SheetsF- 3Consolidated Statements of OperationsF- 4Consolidated Statements of Comprehensive (Loss) IncomeF- 5Consolidated Statements of Stockholders’ EquityF- 6Consolidated Statements of Cash FlowsF- 7Notes to Consolidated Financial StatementsF- 82. Financial Statement Schedules.All schedules are omitted as the required information is inapplicable, or the information is presented in the consolidated financial statements or relatednotes.3. Exhibits.A list of exhibits to this Annual Report on Form 10-K is set forth on the Exhibit Index immediately preceding the signature page to this Annual Reporton Form 10-K and is incorporated herein by reference.(b) See Exhibit Index.(c) See Item 15(a)(2) above.70Table of ContentsZogenix, Inc.Index to Consolidated Financial Statements Report of Independent Registered Public Accounting FirmF- 2Consolidated Balance SheetsF- 3Consolidated Statements of OperationsF- 4Consolidated Statements of Comprehensive (Loss) IncomeF- 5Consolidated Statements of Stockholders’ EquityF- 6Consolidated Statements of Cash FlowsF- 7Notes to Consolidated Financial StatementsF- 8F- 1Table of ContentsReport of Independent Registered Public Accounting FirmTo the Shareholders and the Board of Directors of Zogenix, Inc.Opinion on the Financial StatementsWe have audited the accompanying consolidated balance sheets of Zogenix, Inc. (the “Company”) as of December 31, 2017 and 2016, the relatedconsolidated statements of operations, comprehensive (loss) income, stockholders’ equity, and cash flows, for each of the three years in the period endedDecember 31, 2017, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in allmaterial respects, the financial position of the Company as of December 31, 2017 and 2016, and the results of its operations and its cash flows for each of thethree years in the period ended December 31, 2017, in conformity with U.S. generally accepted accounting principles.We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (“PCAOB”), theCompany's internal control over financial reporting as of December 31, 2017, based on criteria established in Internal Control-Integrated Framework issuedby the Committee of Sponsoring Organizations of the Treadway Commission (2013 Framework) and our report dated March 6, 2018 expressed an unqualifiedopinion thereon.Basis for OpinionThese financial statements are the responsibility of the Company‘s management. Our responsibility is to express an opinion on the Company‘sfinancial statements based on our audits. We are a public accounting firm registered with the PCAOB and are required to be independent with respect to theCompany in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and thePCAOB.We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtainreasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. Our audits included performingprocedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond tothose risks. Such procedures include examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits alsoincluded evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of thefinancial statements. We believe that our audits provide a reasonable basis for our opinion./s/ Ernst & Young LLPWe have served as the Company’s auditor since 2007.Redwood City, CaliforniaMarch 6, 2018F- 2Table of ContentsZogenix, Inc.Consolidated Balance Sheets(In thousands, except per share amounts) December 31, 2017 2016Assets Current assets: Cash and cash equivalents$293,503 $91,551Trade accounts receivable— 12,577Inventory— 7,047Prepaid expenses5,994 7,404Other current assets5,206 1,335Total current assets304,703 119,914Property and equipment, net245 1,710Indefinite-lived intangible asset102,500 102,500Goodwill6,234 6,234Other assets3,931 1,147Total assets$417,613 $231,505Liabilities and stockholders’ equity Current liabilities: Accounts payable$3,356 $4,549Accrued expenses10,499 6,374Common stock warrant liabilities512 809Accrued compensation6,616 3,652Working capital advance note payable, net of discount of $3,733 at December 31, 2016— 3,267Deferred revenue— 1,245Current liabilities of discontinued operations— 414Total current liabilities20,983 20,310Long-term debt— 18,824Contingent consideration76,900 52,800Deferred tax liability17,425 17,425Other long-term liabilities784 1,390Commitments and contingencies Stockholders’ equity: Common stock, $0.001 par value; 50,000 shares authorized; 34,808 and 24,813 shares issued andoutstanding at December 31, 2017 and 2016, respectively.35 25Additional paid-in capital873,526 565,954Accumulated deficit(572,040) (445,223)Total stockholders’ equity301,521 120,756Total liabilities and stockholders’ equity$417,613 $231,505See accompanying notes to the consolidated financial statements.F- 3Table of ContentsZogenix, Inc.Consolidated Statements of Operations(In thousands, except per share amounts) Year Ended December 31, 2017 2016 2015Revenue: Contract manufacturing revenue$9,821 $28,525 $24,369Service and other product revenue— 325 2,813Total revenue9,821 28,850 27,182Operating expenses (income): Cost of contract manufacturing10,729 22,173 22,356Royalty expense— 295 345Research and development67,449 41,840 27,860Selling, general and administrative25,885 26,996 26,347Loss on contract termination478 — —Change in fair value of contingent consideration24,100 1,800 (2,000)Asset impairment charges1,116 8,431 —Total operating expenses129,757 101,535 74,908Loss from operations(119,936) (72,685) (47,726)Other income (expense): Interest income1,090 443 101Interest expense(2,644) (2,825) (3,060)Loss on sale of marketable securities— — (5,746)Loss on extinguishment of debt(4,876) — —Change in fair value of common stock warrant liabilities297 5,387 (1,103)Other income (expense)47 46 (71)Total other income (expense)(6,086) 3,051 (9,879)Loss from continuing operations before income taxes(126,022) (69,634) (57,605)Income tax benefit— 948 15,901Loss from continuing operations(126,022) (68,686) (41,704)Discontinued operations: (Loss) income from discontinued operations(795) (1,021) 67,848Net (loss) income$(126,817) $(69,707) $26,144Net (loss) income per share, basic and diluted Net (loss) income per share, basic: Continuing operations$(4.62) $(2.77) $(1.94)Discontinued operations$(0.03) $(0.04) $3.16Total$(4.65) $(2.81) $1.22Net (loss) income per share, diluted: Continuing operations$(4.62) $(2.77) $(1.94)Discontinued operations$(0.03) $(0.04) $3.16Total$(4.65) $(2.81) $1.22Weighted average shares outstanding, basic27,301 24,785 21,449Weighted average shares outstanding, diluted27,301 24,785 21,449See accompanying notes to the consolidated financial statements.F- 4Table of ContentsZogenix, Inc.Consolidated Statements of Comprehensive (Loss) Income(in thousands) Year Ended December 31, 2017 2016 2015Net (loss) income$(126,817) $(69,707) $26,144Other comprehensive (loss) income: Unrealized loss on marketable securities— — (5,485)Reclassification of other-than-temporary loss on marketable securities included in netincome— — 5,485Comprehensive (loss) income$(126,817) $(69,707) $26,144See accompanying notes to the consolidated financial statements.F- 5Table of ContentsZogenix, Inc.Consolidated Statements of Stockholders’ Equity(in thousands) Common Stock AdditionalPaid-inCapital Accumulated OtherComprehensive(Loss)/Income AccumulatedDeficit TotalStockholders’Equity Shares Amount Balance at December 31, 201419,170 $19 $456,920 $— $(401,660) $55,279Net income— — — — 26,144 26,144Issuance of common stock, net of offering costs5,463 5 92,002 — — 92,007Issuance of common stock upon net exercise ofcommon stock warrants17 — — — — —Issuance of common stock upon exercise of stockoptions96 1 1,440 — — 1,441Issuance of common stock under Employee StockPurchase Plan26 — 203 — — 203Stock-based compensation— — 7,686 — — 7,686Unrealized loss on marketable securities— — — 5,485 — 5,485Reclassification of other-than-temporary loss onmarketable securities included in net income (loss)— — — (5,485) — (5,485)Balance at December 31, 201524,772 $25 $558,251 $— $(375,516) $182,760Net loss— — — — (69,707) (69,707)Issuance of common stock upon exercise of stockoptions6 — 47 — — 47Issuance of common stock under Employee StockPurchase Plan35 — 303 — — 303Stock-based compensation— — 7,353 — — 7,353Balance at December 31, 201624,813 $25 $565,954 $— $(445,223) $120,756Net loss— — — — (126,817) (126,817)Issuance of common stock, net of offering costs9,256 9 290,582 — — 290,591Issuance of common stock upon net exercise ofcommon stock warrants26 — — — — —Issuance of common stock upon exercise of stockoptions677 1 10,477 — — 10,478Issuance of common stock under Employee StockPurchase Plan36 — 358 — — 358Stock-based compensation— — 6,155 — — 6,155Balance at December 31, 201734,808 $35 $873,526 $— $(572,040) $301,521See accompanying notes to the consolidated financial statements.F- 6Table of ContentsZogenix, Inc.Consolidated Statements of Cash Flows(in thousands) Year Ended December 31, 2017 2016 2015Operating activities: Net (loss) income$(126,817) $(69,707) $26,144Adjustments to reconcile net (loss) income to net cash used in operating activities: Stock-based compensation6,155 7,353 7,686Depreciation425 1,402 1,621Amortization of debt issuance costs and debt discount887 991 791Change in fair value of common stock warrant liabilities(297) (5,387) 1,103Change in fair value of contingent consideration24,100 1,800 (2,000)Inventory write-down2,232 — —Asset impairment charges1,116 8,431 —Loss on sale of marketable securities— — 5,746Loss on extinguishment of debt4,876 — —Gain on sale of business— — (89,484)Changes in operating assets and liabilities: Trade accounts receivable9,356 (11,181) 7,477Inventory2,583 4,983 1,394Prepaid expenses and other current assets(801) (3,394) (650)Other assets(2,784) 471 316Accounts payable, accrued expenses and other liabilities4,340 (1,778) (14,232)Deferred revenue(1,245) (5,839) (8,464)Deferred tax liability— (1,025) (2,050)Net cash used in operating activities(75,874) (72,880) (64,602)Investing activities: Purchases of property and equipment(76) (103) (308)Proceeds from divestiture of businesses— — 82,984Change in restricted cash from divestiture of businesses— 10,002 (1,502)Proceeds from sale of marketable securities— — 4,371Net cash (used in) provided by investing activities(76) 9,899 85,545Financing activities: Proceeds from borrowings— 2,167 —Principal repayments of long-term debt(20,000) (3,334) (1,450)Payment of fees to extinguish long-term debt(1,865) — —Proceeds from issuance of common stock under equity incentive plans9,176 350 1,441Proceeds from issuance of common stock, net of offering costs290,591 — 92,210Net cash provided by (used in) financing activities277,902 (817) 92,201Net increase (decrease) in cash and cash equivalents201,952 (63,798) 113,144Cash and cash equivalents at beginning of period91,551 155,349 42,205Cash and cash equivalents at end of period$293,503 $91,551 $155,349Supplemental disclosure of cash flow information: Cash paid for interest$1,475 $1,470 $1,466Noncash investing and financing activities: Extinguishment of Endo working capital advance note payable through net settlement of balances owed to theCompany$7,000 $— $—See accompanying notes to the consolidated financial statements.F- 7Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements 1. Organization and Description of BusinessZogenix, Inc. and subsidiaries (the “Company”) is a pharmaceutical company developing and commercializing innovative central nervous system(“CNS”) therapies for people living with serious and life-threatening rare CNS disorders and medical conditions. The Company’s current primary area oftherapeutic focus is rare, or “orphan” childhood-onset epilepsy disorders.The Company was incorporated as SJ2 Therapeutics, Inc. in May 2006 in the State of Delaware and changed its name to Zogenix, Inc. in August 2006.The Company operates in one business segment—the research, development and commercialization of pharmaceutical products and its headquarters arelocated in Emeryville, California.The Company performed contract manufacturing services under a supply agreement through April 2017.In April 2015, the Company divested its Zohydro ER business. Zohydro ER activity has been excluded from continuing operations for all periodsherein and reported as discontinued operations.Future Funding RequirementsExcluding gains from two discrete business divestitures, the Company has incurred significant net losses and negative cash flows from operatingactivities resulting in an accumulated deficit of $572.0 million as of December 31, 2017. Management expects to continue to incur significant operatinglosses and negative cash flows from operations as the Company continues to incur costs related to its ongoing Phase 3 clinical trials of ZX008 in NorthAmerica and the European Union (“EU”) in Dravet syndrome and a Phase 3 clinical trial in Lennox-Gastaut syndrome (“LGS”), which commenced inNovember 2017. Additionally, upon acceptance of the Company’s regulatory submissions for ZX008 by the U.S. Food and Drug Administration (“FDA”) orthe European Medicines Agency (“EMA”), if at all, each a milestone event, the Company will owe milestone payments under an existing agreement inconnection with the Company’s prior acquisition of ZX008. Through December 31, 2017, the Company has relied primarily on the proceeds from equityofferings to finance its operations. Until such time, if ever, the Company can generate a sufficient amount of revenue to finance its cash requirements, theCompany may need to continue to rely on additional financing to achieve its business objectives. However, if such financing is not available at adequatelevels when needed, the Company may be required to significantly delay, scale back or discontinue one or more of the product development programs orcommercialization efforts or other aspects of its business plans, and its operating results and financial condition would be adversely affected.2. Summary of Significant Accounting PoliciesBasis of PresentationThese consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States(“GAAP”) and include the accounts of Zogenix and its wholly owned subsidiaries. The functional currency of the Company’s foreign subsidiaries is the U.S.dollar. All intercompany transactions have been eliminated in consolidation.Use of EstimatesThe preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect theamounts reported in the consolidated financial statements and accompanying notes. Actual results may differ materially from those estimates. The Companybelieves significant judgment is involved in determining and in estimating the valuation of stock-based compensation, accrued clinical expenses, andcontingent consideration liabilities. These estimates form the basis for making judgments about the carrying values of assets and liabilities when these valuesare not readily apparent from other sources. Business CombinationsThe Company measures all assets acquired and liabilities assumed, including contingent consideration, at fair value as of the acquisition date.Contingent consideration obligations incurred in connection with a business combination are remeasured to their estimated fair values at each reportingperiod with the change in fair value recorded in operating expenses until the related contingencies are resolved. In addition, the Company capitalizes in-process research and development (“IPR&D”) and either amortizes it over the life of the product upon commercialization, or impairs it if the carrying valueexceeds the fair value or if the project is abandoned. Post-acquisition adjustments in deferred tax liabilities are recorded in current period income tax expensein the period of the adjustment.Discontinued OperationsIn April 2015, the Company sold its Zohydro ER business. The operating results of the Zohydro ER business have beenF- 8Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)excluded from continuing operations for all periods herein and reported as discontinued operations. See Note 5, Sale of Zohydro ER business, for additionalinformation on the divestiture.Cash and Cash EquivalentsThe Company considers cash equivalents to be only those investments which are highly liquid, readily convertible to cash and have an originalmaturity of three months or less when purchased.Accounts ReceivableThe Company records its allowance for doubtful accounts based upon its assessment of various factors, including historical experience, the length oftime the receivables are past due and the financial health of the customer.Fair Value MeasurementsCertain of the Company’s financial instruments, including cash and cash equivalents, other current assets, accounts payable and accrued liabilitiesapproximates their fair value due to their short maturities. The carrying amount of the Company’s Term Loan (as defined in Note 8 below) at December 31,2016 approximates fair value, considering Level 2 inputs, because it has a variable interest rate. At December 31, 2016, the estimated fair value of theCompany’s working capital advance note payable approximated its face amount due to its impending maturity upon Endo International plc (“Endo”) and theCompany finalizing an agreement to terminate the supply agreement to manufacture and supply Sumavel DosePro to Endo (the “Endo Supply Agreement”).Accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:Level 1:Observable inputs such as quoted prices in active markets;Level 2:Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; andLevel 3:Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions.The fair value of cash equivalents was determined based on Level 1 inputs utilizing quoted prices in active markets. The fair value of the Company’scommon stock warrant liabilities and contingent consideration liabilities were determined based on Level 3 inputs using valuation models with significantunobservable inputs. Assets and liabilities measured at fair value on a recurring basis at December 31, 2017 and 2016 were as follows (in thousands): Fair Value Measurements at Reporting Date UsingQuoted Pricesin ActiveMarkets forIdentical Assets(Level 1) SignificantOtherObservableInputs(Level 2) SignificantUnobservableInputs(Level 3) TotalAt December 31, 2017 Assets Cash equivalents (1)$289,782 $— $— $289,782Liabilities Common stock warrant liabilities (2)$— $— $512 $512Contingent purchase consideration (3)$— $— $76,900 $76,900 At December 31, 2016 Assets Cash equivalents (1)$87,792 $— — $87,792Liabilities Common stock warrant liabilities (2)$— $— $809 $809Contingent purchase consideration (3)$— $— $52,800 $52,800F- 9Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued) (1)Cash equivalents are comprised of money market fund shares and are included as a component of cash and cash equivalents on the consolidated balancesheets.(2)Represents the fair value of common stock warrants outstanding that may require cash settlement under certain circumstances. The Company estimatedthe fair value of the warrant liabilities using the Black-Scholes valuation model. As of December 31, 2017, common stock warrant liabilities consisted ofwarrants issued in July 2011 in connection with a debt financing arrangement. The warrants entitle the holder to purchase up to 28,125 shares ofcommon stock at an exercise price of $72.00 per share. The warrants will expire in July 2021. As of December 31, 2016, common stock warrant liabilitieswere primarily attributable to warrants sold as part of the Company’s July 2012 public offering. The warrants were exercisable into 1,901,918 shares ofthe Company’s common stock at an exercise price of $20.00 per share and had a contractual term of 5 years from the issuance date. In July 2017, thesewarrants expired unexercised.(3)In connection with the acquisition of ZX008 in 2014, the Company may be required to pay future consideration that is contingent upon the achievementof specified development, regulatory approval or sales-based milestone events. The Company estimates the fair value of contingent purchaseconsideration liabilities using a probability-weighted income approach, which reflects the probability and timing of future payments. This fair valuemeasurement is based on significant Level 3 inputs such as the anticipated timelines and probability of achieving development, regulatory approval orsales-based milestone events and projected revenues. The resulting probability-weighted cash flows are discounted at risk-adjusted rates. Subsequent tothe acquisition date, at each reporting period prior to settlement, the Company revalues these liabilities by performing a review of the assumptions listedabove and records an adjustment to reflect any changes in the estimated fair values of these contingent consideration liabilities. In the absence of anysignificant changes in key assumptions during a reporting period, the change in fair values of these contingent consideration liabilities would primarilyreflect an increase in fair value from the passage of time. Significant judgment is used in determining Level 3 inputs and fair value measurements as of areporting period. Updates to assumptions could have a significant impact on the Company’s results of operations in a reporting period and actual resultsmay differ from estimates. For example, significant increases in the estimated probability of achieving a milestone or projected revenues would result in asignificantly higher fair value measurement while significant decreases in the estimated probability of achieving a milestone or projected revenueswould result in a significantly lower fair value measurement. Significant increases in the discount rate or in the anticipated timelines would result in asignificantly lower fair value measurement while significant decreases in the discount rate or anticipated timelines would result in a significantly higherfair value measurement. The potential contingent consideration payments required upon achievement of development, regulatory approval and sales-based milestones related to the Company’s acquisition of ZX008 range from zero if none of the milestones are achieved to a maximum of $95.0 million(undiscounted).There were no transfers between levels for all periods presented.The following table provides a reconciliation of assets and liabilities measured at fair value on a recurring basis using significant unobservable inputs(Level 3) for the years ended December 31, 2017 and 2016 (in thousands): ContingentPurchaseConsideration Common StockWarrantLiabilitiesBalance at December 31, 2015 $51,000 $6,196Additions — —Settlements — —Changes in fair value 1,800 (5,387)Balance at December 31, 2016 52,800 809Additions — —Settlements — —Changes in fair value 24,100 (297)Balance at December 31, 2017 $76,900 $512F- 10Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Changes in the estimated fair value of contingent purchase consideration are reflected as operating expenses in the consolidated statements ofoperations. Changes in the estimated fair value of common stock warrant liabilities are included within other income (expense) in the consolidatedstatements of operations.InventoryInventory is stated at the lower of cost or market. Cost includes amounts related to materials, labor and overhead, and is determined in a manner whichapproximates the first-in, first-out method. The Company adjusts the carrying value of inventory for potentially excess, dated or product within one year ofexpiration and obsolete products based on an analysis of inventory on hand and compared to forecasts of future sales. As of December 31, 2016, the entireinventory balance consisted of raw materials and work-in-process related to the fulfillment of Sumavel DosePro under the supply agreement with Endo. Uponthe termination of Endo Supply Agreement in September 2017, the Company no longer engages in contract manufacturing and therefore no longer carriesinventory.Concentration of RiskFinancial instruments that potentially subject the Company to concentrations of credit risk consist primarily of cash and cash equivalents. TheCompany maintains accounts in federally insured financial institutions in excess of federally insured limits. The Company also holds money market fundsthat are not federally insured. However, management believes the Company is not exposed to significant credit risk due to the financial position of thedepository institutions in which these deposits are held and of the money market funds and other entities in which these investments are made. Additionally,the Company has established guidelines regarding the diversification of its investments and their maturities, which are designed to maintain safety andliquidity.Certain materials and key components that the Company utilizes in its operations are obtained through single suppliers. Since the suppliers of keycomponents and materials must be named in a new drug application (NDA) filed with the U.S. Food and Drug Administration (FDA) for a product, significantdelays can occur if the qualification of a new supplier is required. If delivery of material from the Company’s suppliers were interrupted for any reason, theCompany may be unable to supply any of its product candidates for clinical trials.Property and Equipment, NetProperty and equipment is recorded at cost, net of accumulated depreciation. Depreciation is calculated on a straight-line basis over the estimateduseful lives of the respective assets and primarily consists of the following:Computer equipment and software 3 yearsFurniture and fixtures 3-7 yearsLeasehold improvements Shorter of estimated useful life or lease termDepreciation expense for 2017, 2016 and 2015 was $0.4 million, $1.4 million and $1.6 million, respectively.Goodwill and Indefinite-Lived Intangible AssetsGoodwill and indefinite-lived intangible assets are reviewed for impairment at least annually in the fourth quarter, and more frequently if events orother changes in circumstances indicate that the carrying amount of the assets may not be recoverable. Impairment of goodwill and indefinite-livedintangibles is determined to exist when the fair value is less than the carrying value of the net assets being tested.GoodwillThe difference between the purchase price and the fair value of assets acquired and liabilities assumed in a business combination is allocated togoodwill. Goodwill is evaluated for impairment on an annual basis as of October 1, and more frequently if indicators are present or changes in circumstancessuggest that impairment may exist.As of October 1, 2017, the Company has determined through its quantitative test that the fair value significantly exceeded the carrying value of oursingle reporting unit, and concluded that goodwill was not impaired. The Company has not recognized any goodwill impairment in any of the yearspresented.F- 11Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Indefinite-Lived Intangible AssetThe Company’s indefinite-lived intangible asset consists of IPR&D acquired in a business combination that are used in research and developmentactivities but have not yet reached technological feasibility, regardless of whether they have alternative future use. The primary basis for determining thetechnological feasibility or completion of these projects is obtaining regulatory approval to market the underlying products in an applicable geographicregion. The Company classifies IPR&D acquired in a business combination as an indefinite-lived intangible asset until the completion or abandonment ofthe associated research and development efforts. Upon completion of the associated research and development efforts, the Company performed a final test forimpairment and will determine the useful life of the technology and begin amortizing the assets to reflect their use over their remaining lives. Uponpermanent abandonment, the Company would write-off the remaining carrying amount of the associated IPR&D intangible asset.In performing each annual impairment assessment and any interim impairment assessment, the Company determines if it should qualitatively assesswhether it is more likely than not that the fair value of its IPR&D asset is less than its carrying amount (the qualitative impairment test). If the Companyconcludes that is the case, or elect not to use qualitative impairment test, the Company would proceed with quantitatively determining the fair value of theIPR&D asset and comparing its fair value to its carrying value to determine the amount of impairment, if any (the quantitative impairment test).In performing the qualitative impairment test, the Company considers the results of the most recent quantitative impairment test and identifies the mostrelevant drivers of the fair value for the IPR&D asset. The most relevant drivers of fair value identified are consistent with the assumptions used in thequantitative estimate of the IPR&D asset discussed below. Using these drivers of fair value, the Company identifies events and circumstances that may havean effect on the fair value of the IPR&D asset since the last time the IPR&D’s fair value was quantitatively determined. The Company then weighs thesefactors to determine and conclude if it is not more likely than not that the IPR&D asset is impaired. If it is more likely than not that the IPR&D asset isimpaired, the Company proceeds with quantitatively determining the fair value of the IPR&D asset. For 2017, the Company performed a qualitative test andconcluded that it is more likely than not that the fair value of its IPR&D asset exceeded its carrying value and no further testing was required.The Company uses the income approach to determine the fair value of its IPR&D asset. This approach calculates fair value by estimating the after-taxcash flows attributable to an in-process project over its useful life and then discounting these after-tax cash flows back to a present value. This estimateincludes significant assumptions regarding the estimates that market participants would make in evaluating the IPR&D asset, including the probability ofsuccessfully completing clinical trials and obtaining regulatory approval to market the IPR&D asset, the timing of and the expected costs to complete IPR&Dprojects, future net cash flows from potential drug sales, which are based on estimates of the sales price of the drug, the number of patients who will bediagnosed and treated and our competitive position in the marketplace, and appropriate discount and tax rates. Any impairment to be recorded is calculatedas the difference between the fair value of the IPR&D asset as of the date of the assessment with the carrying value of the IPR&D asset on its consolidatedbalance sheet.For 2017, the Company performed a qualitative test and concluded that it is more-likely-than-not that the fair value of our IPR&D asset exceeded thecarrying value and no further testing was required. The Company did not recognize any IPR&D impairment in any of the years presented.Impairment of Long-Lived AssetsThe Company evaluates long-lived assets periodically for impairment whenever events or changes in circumstances indicate that the carrying amountof an asset (group) may not be recoverable. An impairment loss would be recognized when the carrying amount of the assets (asset group) exceeds theestimated undiscounted net cash flows. The amount of the impairment loss to be recorded is calculated as the excess of the carrying value of the assets (assetgroup) over their fair value.In the fourth quarter of 2016, the Company was informed by Endo of their decision to discontinue Sumavel DosePro and the Company commenced thewind down of our manufacturing operations related to the supply of Sumavel DosePro to Endo (see Note 6). As a result, the Company performed an analysisto estimate cash flows from property and equipment used in the production of Sumavel DosePro in the fourth quarter of 2016. Based on this analysis, theCompany recognized an impairment charge for long-lived assets of $6.4 million. In the first quarter of 2017, the Company recorded an additional assetimpairment charge of $0.8 million for long-lived manufacturing assets associated with the production of Sumavel DosePro. There was no impairment to long-lived assets in 2015.Common Stock Warrant LiabilitiesIn accordance with accounting guidance for common stock warrants that may potentially require cash settlement under certain circumstances, theCompany classifies such common stock warrants as current liabilities on the consolidated balance sheet. The Company adjusts the carrying value of thesecommon stock warrants to their estimated fair value at each reportingF- 12Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)date with the increases or decreases in the fair value of such warrants recorded as change in fair value of warrant liabilities in the consolidated statement ofoperations.Revenue RecognitionThe Company historically generated revenue from contract manufacturing, service fees earned on collaborative arrangements and product revenuerelated to Sumavel DosePro prior to the sale of the business in May 2014. Until April 2015, the Company generated revenue from the sale of Zohydro ER,which is included in net income (loss) from discontinued operations in the consolidated statement of operations and comprehensive income (loss). Revenuewas recognized when (i) persuasive evidence of an arrangement existed, (ii) delivery had occurred and title had passed, (iii) the price was fixed ordeterminable and (iv) collectability was reasonably assured. Revenue from sales transactions where the buyer has the right to return the product wasrecognized at the time of sale only if (a) our price to the buyer was substantially fixed or determinable at the date of sale, (b) the buyer had paid us, or thebuyer was obligated to pay us and the obligation was not contingent on resale of the product, (c) the buyer’s obligation to us would not be changed in theevent of theft or physical destruction or damage of the product, (d) the buyer acquiring the product for resale had economic substance apart from thatprovided by us, (e) the Company did not have significant obligations for future performance to directly bring about resale of the product by the buyer, and (f)the amount of future returns could be reasonably estimated. The Company deferred recognition of revenue on product shipments of Zohydro ER until theright of return lapsed, as the Company was not able to reliably estimate expected returns of the product at the time of shipment given the limited sales andreturn history of Zohydro ER.Revenue arrangements with multiple elements were divided into separate units of accounting if certain criteria were met, including whether thedelivered element had stand-alone value to the customer. The consideration received was allocated among the separate units based on their respective fairvalues, and the applicable revenue recognition criteria were applied to each of the separate units. The application of the multiple element guidance requiressubjective determinations, and required the Company to make judgments about the individual deliverables and whether such deliverables were separablefrom the other aspects of the contractual relationship. Deliverables were considered separate units of accounting provided that: (1) the delivered item(s) hadvalue to the customer on a stand-alone basis and (2) if the arrangement included a general right of return relative to the delivered item(s), delivery orperformance of the undelivered item(s) was considered probable and substantially in our control. In determining the units of accounting, the Companyevaluated certain criteria, including whether the deliverables have stand-alone value, based on the consideration of the relevant facts and circumstances foreach arrangement. In addition, the Company considered whether the buyer could use the other deliverable(s) for their intended purpose without the receipt ofthe remaining element(s), whether the value of the deliverable was dependent on the undelivered item(s), and whether there were other vendors that couldprovide the undelivered element(s).Arrangement consideration that is fixed or determinable was allocated among the separate units of accounting using the relative selling price method,and the applicable revenue recognition criteria, as described above, was applied to each of the separate units of accounting in determining the appropriateperiod or pattern of recognition. The Company determined the estimated selling price for deliverables within each agreement using vendor-specific objectiveevidence (“VSOE”) of selling price, if available, third-party evidence (“TPE”) of selling price if VSOE is not available, or management’s best estimate ofselling price (“BESP”) if neither VSOE nor TPE is available. Determining the BESP for a unit of accounting requires significant judgment. In developing theBESP for a unit of accounting, the Company considered applicable market conditions and relevant entity-specific factors, including factors that werecontemplated in negotiating the agreement with the customer and estimated costs.Contract Manufacturing RevenueThe Company recorded deferred revenue when payments are received in advance of the delivery of products or the performance of services. As part ofthe sale of our Sumavel DosePro business in May 2014 to Endo, the Company allocated a portion of the total consideration received as payments in advanceof the delivery of product under the Endo Supply Agreement that was concurrently entered into with the asset sale. The Company initially recorded $9.1million of deferred revenue, which was being recognized as contract manufacturing revenue when earned on a “proportional performance” basis as productwas delivered. As a result, a portion of contract manufacturing revenue reported included deferred revenue from this transaction being recognized whenearned.Under the proportional performance method, revenue recognition is based on products delivered to date relative to the total expected products to bedelivered over the performance period as this is considered to be representative of the delivery of service under the arrangement. Management exercisesjudgment to estimate the total expected products to be delivered under the Endo Supply Agreement and actual results may differ from these estimates. Theperformance period under the Endo Supply Agreement was initially estimated to be 8 years, the minimum contractual term under the agreement. Changes inestimates ofF- 13Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)total expected products to be delivered or service obligation time period were accounted for prospectively as a change in estimate. In the fourth quarter of2016, as a result of Endo’s intent to terminate the supply agreement by the first half of 2017, we revised our estimates of total expected products to bedelivered under the arrangement and recognized revenue for the inception-to-date effect of the change in estimate. The effect of this change in estimateresulted in an increase to 2016 revenue by $4.9 million. All remaining deferred revenue related to the Endo Supply Agreement was recognized in 2017concurrent with the shipment of final product and termination of this agreement.After the termination of the agreements with Durect related to Relday and Endo related to Sumavel DosePro, respectively, the Company no longer hasa source of recurring revenue.The Company generated service revenue under a co-promotion agreement with Valeant Pharmaceuticals North America LLC (Valeant), which wasterminated in July 2015, and other product revenue upon expiration of return rights for Sumavel DosePro products sold prior to the Company’s divestiture.Research and Development Expense and AccrualsResearch and development costs are expensed as incurred unless there is an alternative future use in other research and development projects. Researchand development costs include personnel-related costs, outside contracted services including clinical trial costs, facilities costs, fees paid to consultants,milestone payments prior to FDA approval, license fees prior to FDA approval, professional services, travel costs, dues and subscriptions, depreciation andmaterials used in clinical trials and research and development. The Company expenses costs relating to the purchase and production of pre-approvalinventories as research and development expense in the period incurred until FDA approval is received. Payments made prior to the receipt of goods orservices to be used in research and development are capitalized until the goods or services are received. Such payments are evaluated for current or long-termclassification based on when they will be realized.The Company’s expense accruals for clinical trials are based on estimates of the services received from clinical trial investigational sites and contractresearch organizations (“CROs”). Payments under some of the Company’s contracts with such parties depend on factors such as the milestones accomplished,successful enrollment of certain numbers of patients, site initiation and the completion of clinical trial milestones. In accruing service fees, the Companyestimates the time period over which services will be performed and the level of effort to be expended in each period. If possible, the Company obtainsinformation regarding unbilled services directly from these service providers. However, the Company may be required to estimate these services based oninformation available to its product development or administrative staff. If the Company underestimates or overestimates the activity associated with a studyor service at a given point in time, adjustments to research and development expenses may be necessary in future periods.For asset purchases outside of business combinations, the Company expenses any purchased research and development assets as of the acquisition dateif they have no alternative future uses.Income TaxesIncome taxes are accounted for under the asset and liability method of accounting. Deferred tax assets and liabilities are recognized for the future taxconsequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases, aswell as for operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxableincome in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a changein tax rates is recognized in the results of operations in the period that includes the enactment date. The Company provides a valuation allowance against netdeferred tax assets unless, based upon the available evidence, it is more likely than not that the deferred tax asset will be realized. The Company recognizesthe tax benefit from an uncertain tax position only if it is more likely than not that the tax position will be sustained on examination by the taxing authoritiesbased on the technical merits of the position.On December 22, 2017, the Securities and Exchange Commission (“SEC”) staff issued Staff Accounting Bulletin No. 118 (“SAB 118”) to address theaccounting implications of the U.S. federal tax reform enacted on December 22, 2017. SAB 118 allows a company to record provisional amounts during ameasurement period not to extend beyond one year of the enactment date.Foreign Currency TransactionsGains or losses resulting from transactions denominated in foreign currencies are included in other expense, net in the consolidated statements ofoperations and were not material for all periods presented.F- 14Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Stock-Based CompensationThe Company recognizes stock-based compensation for all equity awards made to employees based upon the awards’ estimated grant date fair value.For equity awards that vest subject to the satisfaction of service requirements, compensation expense is measured based on the fair value of the award on thedate of grant and is recognized as expense on a straight-line basis over the requisite service period. For stock awards which have a performance component,compensation cost is measured based on the fair value on the grant date (the date performance targets are established) and is expensed over the service periodfor each separately vesting tranche when the achievement of the performance objective becomes probable. The Company has elected to recognize forfeituresas they occur.Valuation of Stock OptionsThe fair value of each option granted was estimated on the date of grant using the Black-Scholes option-pricing model with the following assumptions:•Expected term—The expected term of the option awards represents the period of time between the grant date of the option awards and the date theoption awards are either exercised, converted or canceled, including an estimate for those option awards still outstanding. The Company used thesimplified method, as permitted by the SEC for companies with a limited history of relevant stock option exercise activity, to determine theexpected term for its option grants.•Expected volatility—The expected volatility was calculated based on the Company’s historical stock prices, supplemented as necessary withhistorical volatility of the common stock of several peer companies with characteristics similar to those of the Company.•Risk-free interest rate—The risk-free interest rate was based on the U.S. Treasury yield curve in effect at the time of grant and with a maturity thatapproximated the Company’s expected term.•Dividend yield—The dividend yield was based on the Company’s dividend history and the anticipated dividend payout over its expected term.Valuation of Restricted Stock UnitsThe fair value of each restricted stock unit was based on the Company’s closing stock price on the date of grant. The Company is also required to makeestimates as to the probability of achieving the specific performance criteria. If actual results are not consistent with the Company’s assumptions andjudgments used in making these estimates, the Company may be required to increase or decrease compensation expense, which could be material to theCompany’s results of operations.Loss from Continuing Operations per ShareBasic net loss from continuing operations per share is calculated by dividing the net loss from continuing operations by the weighted average numberof common shares outstanding for the period reduced by weighted average shares subject to repurchase, without consideration for common stock equivalents.Diluted net loss from continuing operations per share is computed by dividing the net loss from continuing operations by the weighted average number ofcommon share equivalents outstanding for the period determined using the treasury-stock method and as-if converted method, as applicable. For purposes ofthis calculation, stock options, restricted stock units and warrants are considered to be common stock equivalents and are only included in the calculation ofdiluted net loss from continuing operations per share when their effect is dilutive.The calculation of diluted loss per share also requires that, to the extent the average market price of the underlying shares for the reporting periodexceeds the exercise price of the common stock warrants and the presumed exercise of such securities are dilutive to loss per share for the period, adjustmentsto net income or net loss used in the calculation are required to remove the change in fair value of the common stock warrant liability for the period.Likewise, adjustments to the denominator are required to reflect the related dilutive shares.The following table presents the computation of basic and diluted loss from continuing operations per share (in thousands, except per share amounts): 2017 2016 2015Numerator Net loss from continuing operations$(126,022) $(68,686) $(41,704)Denominator Weighted average common shares outstanding, basic and diluted27,301 24,785 21,449Loss from continuing operations per share, basic and diluted$(4.62) $(2.77) $(1.94)The following table presents the potential common shares outstanding that were excluded from the computation of dilutedF- 15Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)loss from continuing operations per share of common stock for the periods presented because including them would have been antidilutive (in thousands): Year Ended December 31, 2017 2016 2015Shares subject to outstanding common stock options3,865 3,171 529Shares subject to outstanding restricted stock units237 85 —Shares subject to outstanding warrants to purchase common stock282 1,975 1,975 4,384 5,231 2,504Accounting Pronouncements Recently AdoptedAccounting Standards Update (“ASU”) 2016-09, Compensation—Stock Compensation (Topic 718): Improvements to Employee Share-Based PaymentAccounting changes how companies account for certain aspects of stock-based awards to employees. Under the guidance, entities will no longer recordexcess tax benefits and certain tax deficiencies in additional paid-in capital. Instead, they will record all excess tax benefits and tax deficiencies as incometax expense or benefit in the income statement. In addition, entities will recognize excess tax benefits regardless of whether the benefit reduces taxes payablein the current period. Under current guidance, excess tax benefits are not recognized until the deduction reduces taxes payable. Further, the new guidanceallows entities to make an accounting policy election to either estimate forfeitures or recognize forfeitures as they occur. If an election is made, the change torecognize forfeitures as they occur must be adopted using a modified retrospective approach with a cumulative effect adjustment recorded to retainedearnings or accumulated deficit. The Company adopted ASU 2016-09 on January 1, 2017. Upon adoption, the Company recorded a deferred tax asset of $0.2 million for previouslyunrecognized excess tax benefits from stock-based compensation, which was fully offset by an equal increase to its valuation allowance resulting in noimpact to opening accumulated deficit. In addition and as provided for under this guidance, the Company made an accounting policy election to recognizeforfeitures as they occur. The adoption of this aspect of the guidance did not have a material impact on the Company’s consolidated financial statements andrelated disclosures.ASU 2015-11, Inventory (Topic 330): Simplifying the Measurement of Inventory simplifies current accounting treatments by requiring entities tomeasure most inventories at “the lower of cost and net realizable value” rather than using lower of cost or market. This guidance does not apply to inventoriesmeasured using the last-in, first-out method or the retail inventory method. The Company adopted ASU 2015-11 on January 1, 2017. The adoption of thisnew guidance did not have any impact on the Company’s consolidated financial statements and related disclosures.Accounting Pronouncements Issued But Not Yet EffectiveASU 2014-09, Revenue from Contracts with Customers (Topic 606) and subsequent amendments to the initial guidance (collectively, “Topic 606”)will replace all current GAAP guidance on this topic and eliminate all industry-specific guidance. The new revenue recognition standard provides a unifiedmodel to determine when and how revenue is recognized. The core principle of Topic 606 is to recognize revenues when promised goods or services aretransferred to customers in an amount that reflects the consideration that is expected to be received for those goods or services. Topic 606 defines a five-stepprocess to achieve this core principle and, in doing so, it is possible more judgment and estimates may be required within the revenue recognition processthan are required under existing GAAP, including identifying performance obligations in the contract, estimating the amount of variable consideration toinclude in the transaction price and allocating the transaction price to each separate performance obligation, among others. This guidance will be effectivefor the Company beginning January 1, 2018. The guidance permits two methods of adoption: retrospectively to each prior reporting period presented (fullretrospective method), or retrospectively with the cumulative effect of initially applying the guidance recognized at the date of initial application (themodified retrospective method). The Company will implement the standard on January 1, 2018 to contracts which are not completed as of this date using themodified retrospective method. This standard will not have a material impact on the Company’s consolidated financial statements as the Company does nothave any contracts with customers in effect as of the initial adoption date.ASU 2016-02, Leases (Topic 842) requires lessees to recognize the lease assets and lease liabilities that arise from both capital and operating leases withlease terms of more than 12 months and to disclose qualitative and quantitative information about lease transactions. The guidance is effective for fiscal yearsbeginning after December 15, 2018, including interim periodsF- 16Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)within those fiscal years. The Company is currently evaluating the timing and impact of adopting this new accounting standard on its consolidated financialstatements and related disclosures.ASU 2017-01, Business Combinations (Topic 805): Clarifying the Definition of a Business provides a screen to determine when an integrated set ofassets and activities is not a business. The screen requires that when substantially all of the fair value of the gross assets acquired (or disposed of) isconcentrated in a single identifiable asset or a group of similar identifiable assets, the set is not a business. To be considered a business, an acquisition wouldhave to include an input and a substantive process that together significantly contribute to the ability to create outputs. To be a business without outputs,there will need to be an organized workforce. The ASU also narrows the definition of the term “outputs” to be consistent with how it is described in Topic606. ASU 2017-01 is effective for annual periods beginning after December 15, 2017, including interim periods within those periods on a prospective basis,and may be early adopted. The Company is currently evaluating the timing and impact of adopting this new accounting standard on its consolidatedfinancial statements and related disclosures.ASU 2017-04, Intangibles-Goodwill and Other (Topic 350): Simplifying the Test for Goodwill Impairment simplifies how an entity is required to testgoodwill for impairment by eliminating Step 2 from the goodwill impairment test. Step 2 measures a goodwill impairment loss by comparing the implied fairvalue of a reporting unit’s goodwill with the carrying amount of that goodwill. Under the amendments in ASU 2017-04, an entity should recognize animpairment charge for the amount by which the carrying amount of a reporting unit exceeds its fair value; however, the loss recognized should not exceed thetotal amount of goodwill allocated to that reporting unit. The updated guidance requires a prospective adoption. ASU 2017-04 is effective for fiscal yearsbeginning after December 15, 2019, including interim periods within those fiscal years. Early adoption is permitted for goodwill impairment tests performedon testing dates after January 1, 2017. The Company is currently evaluating the timing and impact of adopting this new accounting standard on itsconsolidated financial statements and related disclosures.ASU 2017-09, Compensation—Stock Compensation (Topic 718): Scope of Modification Accounting provides guidance on determining changes to theterms and conditions of share-based payment awards and require an entity to apply modification accounting under Topic 718 unless all of the followingconditions are met: (1) the fair value of the modified award is the same as the fair value of the original award immediately before the original award ismodified. If the modification does not affect any of the inputs to the valuation technique that the entity uses to value the award, the entity is not required toestimate the value immediately before and after the modification; (2) the vesting conditions of the modified award are the same as the vesting conditions ofthe original award immediately before the original award is modified; and (3) the classification of the modified award as an equity instrument or a liabilityinstrument is the same as the classification of the original award immediately before the original award is modified. The amendments are effective for annualperiods, and interim periods within those annual periods, beginning after December 15, 2017 and should be applied prospectively to an award modified on orafter the adoption date. The Company is currently evaluating the timing and impact of adopting this new accounting standard on its consolidated financialstatements.3. Collaboration, License and Purchase AgreementsZogenix International Limited Sales and Purchase AgreementIn October 2014, the Company acquired Zogenix International Limited, pursuant to a sale and purchase agreement with Brabant Pharma Limited(Brabant). Zogenix International Limited owns worldwide development and commercialization rights to ZX008 (low-dose fenfluramine). Under the terms ofthe sale and purchase agreement, the Company agreed to make future milestone payments to the former principals of Brabant of up to $95.0 million in theevent the Company achieves certain milestones with respect to ZX008, consisting of $50.0 million in regulatory milestones and $45.0 million in salesmilestones.In addition, Zogenix International Limited has a collaboration and license agreement with the Universities of Antwerp and Leuven in Belgium (theUniversities) that runs through September 2045. Under the terms of the agreement, the Universities granted Zogenix International Limited an exclusiveworldwide license to use the data obtained from the study, as well as certain intellectual property related to fenfluramine for the treatment of Dravetsyndrome. Zogenix International Limited is required to pay a mid-single-digit percentage royalty on net sales of fenfluramine for the treatment of Dravetsyndrome or, in the case of a sublicense of fenfluramine for the treatment of Dravet syndrome, a percentage in the mid-twenties of the sub-licensing revenues.The agreement may be terminated by the Universities if Zogenix International Limited: (a) does not use commercially reasonable efforts to (i) develop andcommercialize fenfluramine for the treatment of Dravet syndrome or related conditions stemming from infantile epilepsy, or (ii) seek approval of fenfluraminefor the treatment of Dravet syndrome in the United States; or (b) if Zogenix International Limited becomes insolvent, shall make an assignment for the benefitof creditors, or shallF- 17Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)have a petition in bankruptcy filed for or against it or if a petition for any similar relief has been filed against it. The Company can terminate the agreementupon specified prior written notice to the Universities.Endo Asset Purchase AgreementIn May 2014, the Company completed the sale of its Sumavel DosePro business to Endo and concurrently entered into the Endo Supply Agreement forthe exclusive right, and contractual obligation, to manufacture and supply Sumavel DosePro to Endo. The agreement provides for an initial term of eightyears. In September 2017, the Endo Supply Agreement was terminated (See Note 6).Durect Development and License Agreement for ReldayIn July 2011, the Company entered into a development and license agreement with Durect under which the Company was granted an exclusiveworldwide development and commercialization license to intellectual property related to Relday. Relday is an investigational, proprietary, long-actingformulation of risperidone, an atypical anti-psychotic agent. Under the development and license agreement, the Company were responsible for the clinicaldevelopment and commercialization of Relday while Durect was responsible for pre-clinical, formulation and chemistry, manufacturing and controlsdevelopment. In addition, the Company was obligated to use commercially reasonable efforts to fund the development and seek and maintain regulatoryapproval for Relday and if successful, to pay Durect up to $103.0 million in total future milestone payments with respect to Relday, subject to and upon theachievement of various development, regulatory, and sales-related milestones.In August 2017, the Company and Durect entered into an agreement to terminate the development and license agreement related to Relday. Under theterms of the termination agreement, all of our development and commercialization rights related to Relday were returned to Durect and all our regulatoryfilings and development information related to Relday will be assigned and/or transferred to Durect. Upon termination, the Company has no furtherobligations to make any potential future milestone payments with respect to Relday. In addition, the termination agreement does not provide the Companywith any future royalty entitlements.Aradigm Corporation Asset Purchase AgreementIn 2006, the Company entered into an asset purchase agreement with Aradigm Corporation (Aradigm). Under the terms of the agreement, Aradigmtransferred all of its tangible assets and intellectual property related to the DosePro needle-free drug delivery system to the Company. Aradigm also grantedthe Company a non-exclusive license under all of its other intellectual property related to the DosePro delivery system prior to the closing of the assetpurchase. Aradigm retained a non-exclusive license, with a right to sublicense, under all transferred intellectual property rights solely for purposes of thepulmonary field, and the Company granted Aradigm a license under other intellectual property rights solely for use in the pulmonary field. Endo paysroyalties to Aradigm Corporation on sales of Sumavel DosePro subsequent to the sale of the business to Endo in May 2014.The Company made an initial payment to Aradigm at the closing of the asset purchase and made an additional milestone payment upon the U.S.commercialization of Sumavel DosePro in 2010. The Company is also required to pay a 3% royalty on global net sales of Sumavel DosePro, by the Companyor one of the Company’s future licensees, if any, until the later of January 2020 or the expiration of the last valid claim of the transferred patents covering themanufacture, use, or sale of the product. The Company recorded the second milestone payment in other assets in the consolidated balance sheet and wasamortizing the prepaid royalties over the estimated useful life of the technology to royalty expense. As a result of Endo’s decision to discontinue SumavelDosePro (see Note 6), the Company recorded an impairment charge of $2.0 million to write off the remaining carrying amount of the prepaid royalties. TheCompany does not expect further royalty payments under this agreement as Sumavel DosePro has been discontinued.Other Asset AcquisitionsIn October 2016, the Company paid $1.5 million to acquire the global rights to a preclinical development program for orphan CNS disorders in an assetacquisition. At the date of acquisition, the project had not yet reached technological feasibility, was deemed to have no alternative use, and was immediatelycharged to research and development expense. The asset purchase agreement provides for potential additional payments if certain development and salesmilestones are achieved. Due to the preclinical stage of development and the nature of this arrangement, any future potential payments related to theattainment of the specified milestones over a period of several years are inherently uncertain.F- 18Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)4. Consolidated Balance Sheet DetailsInventory (in thousands)Inventory consists of the following: December 31, 2017 2016Raw materials$— $4,397Work in process— 2,650 $— $7,047Prior to the termination of the Endo Supply Agreement, the Company maintained inventory to fulfill its obligations to manufacture and supply Endowith Sumavel DosePro. Upon the termination of Endo Supply Agreement in September 2017, the Company no longer engages in contract manufacturing andtherefore no longer carries inventory.Property and Equipment, Net (in thousands) December 31, 2017 2016Machinery, equipment and tooling$— $11,011Construction in progress— 104Computer equipment and software141 78Leasehold improvements976 1,372Furniture and fixtures407 659Total1,524 13,224Less accumulated depreciation(1,279) (11,514)Property and equipment, net$245 $1,710Other Assets (in thousands) December 31, 2017 2016Deposits and other278 376Prepaid clinical trial costs3,653 771 $3,931 $1,147Accrued Expenses (in thousands) December 31, 2017 2016Accrued product returns$— $99Accrued interest payable, current— 121Accrued clinical trial costs8,657 3,657Other accrued expenses1,842 2,497 $10,499 $6,374F- 19Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Other Long-Term Liabilities (in thousands) December 31, 2017 2016Deferred rent$244 $661Accrual for end of term fee related to term loan— 729Other long-term liabilities540 — $784 $1,3905. Divestiture and Sale of Zohydro ER businessIn March 2015, the Company entered into an asset purchase agreement with Pernix Ireland Limited and Pernix Therapeutics (collectively, Pernix)whereby the Company agreed to divest its Zohydro ER business to Pernix, and in April 2015, the Company completed the divestiture to Ferrimill Limited, asubsidiary of Pernix, as a substitute purchaser. The Zohydro ER business divestiture included the registered patents and trademarks, certain contracts, the newdrug application and other regulatory approvals, documentation and authorizations, the books and records, marketing materials and product data relating toZohydro ER.The Company received consideration of $80.0 million in cash, subject to an escrow holdback of $10.0 million, and $10.6 million in PernixTherapeutics common stock. The escrow period expired in March 2016. The Company may receive additional cash payments, not to exceed $283.5 millionbased on the achievement of certain regulatory and sales milestones. As of December 31, 2017, the Company had not received and does not expect to receiveany additional cash payments. The Company recorded an after-tax gain of $75.4 million from the divestiture of its Zohydro ER business in discontinuedoperations in 2015.The results of operations for discontinued operations presented below include certain allocations that management believes fairly reflect the utilizationof services provided to the Zohydro ER business. The allocations do not include amounts related to general corporate administrative expenses or interestexpense. Therefore, the results of operations from the Zohydro ER business do not necessarily reflect what the results of operations would have been had thebusiness operated as a stand-alone entity.The following table summarizes the results of discontinued operations presented in the consolidated statements of operations for the periods indicated(in thousands): Year Ended December 31,Discontinued operations 2017 2016 2015Net product revenue $57 $532 $11,299 Operating expense (income): Cost of product sold — 15 2,205 Royalty expense 3 32 835 Research and development — — 5,504 Selling, general and administrative 920 1,594 14,820Restructuring expense — — 588Gain on sale of business — — (89,484)Total operating expense (income) 923 1,641 (65,532)Other income — — 5,077Net (loss) income from discontinued operations before tax (866) (1,109) 81,908Tax benefit (expense) 71 88 (14,060)Net loss (income) from discontinued operations $(795) $(1,021) $67,848Other income of $5.1 million in 2015 was attributed to payment received for the Company’s waiver of its regulatory exclusivity rights. Assets andliabilities for discontinued operations as of December 31, 2017 and 2016 were not material. Noncash expenses related to stock-based compensation, anddepreciation and amortization expense included in discontinued operations in 2015 was $0.7 million and $0.2 million, respectively. These noncash expenseswere not material in 2017 or 2016.F- 20Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)6. Contract Manufacturing Agreement with Endo and Associated Exit ActivitiesThe Company divested its Sumavel DosePro business to Endo in May 2014. In connection with the divestiture, the Company entered into the EndoSupply Agreement for an initial term of 8 years. As a result of the Company’s continuing involvement through the Endo Supply Agreement, the divestituredid not qualify for discontinued operations presentation based on the accounting guidance applicable at the time. To support the Company’s SumavelDosePro manufacturing operations, Endo provided the Company with an interest-free working capital advance of $7.0 million under a promissory note (seeNote 8). The working capital advance matured upon the termination of the Endo Supply Agreement.In the fourth quarter of 2016, the Company was informed by Endo of their decision to discontinue Sumavel DosePro and the Company commenced thewind down of its manufacturing operations related to the supply of Sumavel DosePro to Endo (see Note 6). As a result, the Company performed an analysis toestimate cash flows from property and equipment used in the production of Sumavel DosePro in the fourth quarter of 2016. Based on this analysis, theCompany recognized an impairment charge for long-lived assets of $6.4 million. In addition, the Company wrote-off the carrying value of prepaid royaltiesof $2.0 million related to certain licensed drug-delivery technology used Sumavel DosePro to impairment charges in the consolidated statements ofoperations.In 2017, the Company recorded an additional asset impairment charge of $0.8 million for long-lived manufacturing assets associated with theproduction of Sumavel DosePro and a $2.2 million reduction to inventory to reflect its current net realizable value. These additional charges reflectedongoing negotiations over the course of finalizing the termination of the Endo Supply Agreement and were included as a component of operating expensesand cost of contract manufacturing, respectively, in the consolidated statements of operations.In September 2017, the Company and Endo executed a termination agreement which resolved all matters under the Supply Agreement. Pursuant to thetermination agreement, the Company received cash consideration of $1.5 million from Endo for reimbursement of a portion of the Company’s terminationcosts for its third-party suppliers and manufacturers related to Sumavel DosePro product. As part of the termination agreement, both parties also agreed to netsettle outstanding accounts receivable of $4.7 million due from Endo and the Company’s remaining purchased raw materials and other costs of $2.3million against the $7.0 million working capital advance note payable due to Endo. In connection with the Endo termination agreement, the Company alsoexecuted termination agreements with its third-party suppliers and manufacturers related to the Sumavel DosePro product and incurred contract terminationcosts of $2.5 million. Excluding the non-cash loss on extinguishment of debt due to the write-off of unamortized discount related to imputed interest (seeNote 8), these termination agreements resulted in a net loss on contract termination of $0.5 million, which has been included in loss on contract terminationwithin continuing operations in the consolidated statements of operations.7. Commitments and ContingenciesThe Company is not currently involved in any material legal proceedings. The Company may become involved in various legal proceedings andclaims that arise in the ordinary course of business. Such matters are subject to uncertainty and there can be no assurance that such legal proceedings will nothave a material adverse effect on its business, results of operations, financial position or cash flows.Operating LeasesThe Company has two noncancelable operating leases consisting of administrative and research and development office space for its Emeryville,California headquarters and former headquarters in San Diego, California that expire in November 2022 and March 2020, respectively. The base rent for theEmeryville headquarters is subject to a 3% increase each year for the duration of the lease. Under the terms of the lease, as amended, the Company received anoption to expand into additional space under certain conditions, as well as a renewal option for an additional five year term upon the expiration date. TheCompany will also pay a portion of common area and pass-through expenses in excess of base year amounts.In September 2017, the Company completely vacated its former headquarters in anticipation of subleasing the available space, which was subleased inOctober 2017 to an unrelated third party pursuant to which it will rent the vacated space through the remainder of the Company’s original lease term.Accordingly, the Company recognized a cease-use liability of $1.1 million. The fair value of the cease-use liability was calculated based on the present valueof the remaining net cash flows related to the Company’s continuing obligations under the lease less the present value of sublease rental payments to bereceived under the sublease agreement over the term of the sublease. The net cash flows were discounted using the Company’s estimated incrementalborrowing rate, a Level 2 input within the fair value hierarchy. Additionally, the Company derecognized the related deferred rent liability in the amountof $0.5 million. These adjustments resulted in a loss on lease of $0.6 million, which hasF- 21Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)been included in general and administrative expenses in the consolidated statements of operations. As of December 2017, accrued operating leaseobligations related to the cease-use liability was $0.9 million, of which $0.5 million was long-term.The Company recognizes rent expense on a straight-line basis over the noncancelable term of its operating leases. Rent expense for 2017, 2016 and2015 was $1.8 million, $1.9 million and $1.5 million, respectively.Future minimum operating lease payments, net of sublease income, were as follows (in thousands): Gross LeasePayments SubleaseIncome Net LeasePayments2018$1,896 $(500) $1,39620191,955 (576) 1,37920201,234 (148) 1,08620211,004 — 1,0042022946 — 946Total$7,035 $(1,224) $5,8118. Debt ObligationsEarly Extinguishment of Term LoanIn December 2014, the Company entered into a Loan and Security Agreement (the “Loan Agreement”) with Oxford Finance LLC (“Oxford”) andSilicon Valley Bank (“SVB”) (collectively, the “Lenders”), under which the Company borrowed a $20.0 million term loan (the “Term Loan”). In addition, theLoan Agreement provided for a revolving credit facility of up to $4.0 million.In connection with the Loan Agreement, the Lenders were issued warrants to purchase 63,559 shares of the Company’s common stock at an exerciseprice per share of $9.44. The warrants have a term of 10 years from the issuance date. The fair value of the warrants at issuance was estimated to be $0.6million using the Black-Scholes valuation model and was recorded as debt discount to the term loan with a corresponding increase to additional paid incapital in the consolidated balance sheet.The term loan bore interest at an annual rate equal to the greater of (i) 8.75% or (ii) the sum of the prime rate plus 5.25%. Payments under the term loanwere interest-only until January 1, 2016, followed by equal monthly payments of principal and interest through the scheduled maturity date of December 1,2018.In April 2015, in connection with the sale of the Zohydro ER business, the Company and the Lenders entered into an amendment to the LoanAgreement, which terminated all encumbrances on the Company’s personal property related to its Zohydro ER business.In June 2016, the Company entered into a second amendment to the Loan Agreement, which modified the loan repayment terms to be interest-onlyfrom July 1, 2016 to February 1, 2018, followed by equal monthly payments of principal and interest through the new maturity date of July 1, 2020. Underthe terms of the second amendment, the interest rate applicable to the term loan bore interest at an annual rate equal to the greater of (i) 7.00% or (ii) the sumof the prime rate plus 3.25%. In addition, the second amendment terminated the revolving credit facility previously available under the Loan Agreement. Inconnection with the second amendment, the Company paid (i) an end of term fee of $1.0 million due under the Loan Agreement as a result of this refinancingand (ii) the end of term fee of $0.1 million with respect to the termination of the revolving credit facility. The second amendment also included an end of termfee of $1.4 million payable on July 1, 2020, or upon early repayment of the term loan. An early repayment would be subject to a prepayment fee.In December 2017, the Company used a portion of the proceeds from the Company’s October 2017 common stock offering (see Note 10) and repaid infull the entire $20.0 million of outstanding principal under the Loan Agreement, plus accrued interest. The Company recognized a $1.5 million loss on earlyextinguishment of debt consisting of a non-cash charge to write off the remaining unamortized debt issuance costs and debt discount associated with thewarrant issued at loan origination. The Company also paid $1.9 million in additional fees for prepayment and termination of the Loan Agreement.F- 22Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Extinguishment of Working Capital Advance Note PayableIn connection with entering into the Supply Agreement for Sumavel DosePro with Endo in May 2014, Endo provided the Company with an interest-free working capital advance of $7.0 million in the form of a note payable to support the Company’s Sumavel DosePro operations. The note payable maturesin the event the Supply Agreement is terminated. The note payable was initially recorded on the consolidated balance sheet net of a $4.7 million debtdiscount related to imputed interest. The debt discount was being amortized as interest expense using the effective interest method over the Endo SupplyAgreement’s initial term of 8 years.In September 2017, the Company and Endo terminated the supply agreement and the note payable became due and payable in accordance with itsterms. Pursuant to the termination agreement, the $7.0 million promissory note was extinguished to settle amounts owed to the Company for accountsreceivable and purchased raw materials (see Note 6). In connection with the extinguishment, the Company recognized a non-cash charge upon debtextinguishment of $3.4 million to write off the remaining unamortized debt discount related to imputed interest.9. Stockholders’ EquityPreferred StockThe Company has 10,000,000 shares of preferred stock authorized for issuance, par value of $0.001 per share. As of December 31, 2017 and 2016, noshares of preferred stock were issued and outstanding.Common StockThe Company has 50,000,000 shares of common stock authorized for issuance, par value of $0.001 per share. Holders of the Company’s common stockare entitled to one vote per share. As of December 31, 2017 and 2016, there were 34,807,509 and 24,813,169 shares of common stock issued and outstanding.The following table presents common stock reserved for future issuance for the following equity instruments as of December 31, 2017 and 2016 (inthousands): December 31, 2017 2016Stock options and restricted stock units outstanding3,651 3,388Warrants to purchase common stock38 1,975Available for future issuance under equity and purchase plans872 952 4,561 6,315Sale of Common StockIn May 2016, the Company entered into an at-the-market sales agreement (the “ATM Agreement”) with Cantor Fitzgerald & Co. (“Cantor”) and filed aregistration statement (File No. 333-211265) and a prospectus for the offer and sale of up to $25.0 million of shares of its common stock from time to time. InAugust and September 2017, the Company sold a total of 1,550,880 shares of its common stock under the ATM Agreement resulting in net proceeds ofapproximately $19.4 million, after deducting underwriting discounts and commissions and other offering expenses. In December 2017, the Company filed aprospectus supplement under its shelf registration statement (File No. 333-220759), for the offer and sale of up to $75.0 million of shares of its common stockfrom time to time pursuant to the ATM Agreement. Cantor is entitled to a commission at a fixed commission rate of up to 3.0% of the gross proceeds of thesales price of all common stock sold under the ATM Agreement. The Company and Cantor may each terminate the ATM Agreement at any time upon tendays’ prior notice. To date, the Company has not sold any shares of common stock under the 2017 prospectus supplement pursuant to the ATM Agreement.In October 2017, the Company completed an underwritten public offering of 7.7 million shares of its common stock, which included 1.0 million sharesof common stock issued upon the exercise in full of the option to purchase additional shares granted to the underwriters in the offering. The shares were soldto the public at an offering price of $37.50 per share. Net proceeds raised from the offering amounted to approximately $271.3 million, after deductingunderwriting discounts and commissions and other offering expenses.F- 23Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Warrants to Purchase Common StockOutstanding warrants to purchase common stock at December 31, 2016 included warrants sold as part of the Company’s 2012 public offering. Thewarrants were exercisable into 1,901,918 shares of the Company’s common stock at an exercise price of $20.00 per share and had a contractual term of 5 yearsfrom the issuance date. In July 2017, these warrants expired unexercised. As of December 31, 2017, the Company had outstanding warrants exercisable into37,840 shares of the Company’s common stock with a weighted-average exercise price of $76.11 per share.10. Stock-Based CompensationDescription of Equity Incentive PlansIn 2006, the Company adopted the 2006 Equity Incentive Award Plan, as amended, (the “2006 Plan”) under which 141,750 shares of common stockwere reserved for issuance to employees, directors and consultants of the Company. The 2006 Plan provides for the grant of incentive stock options, non-qualified stock options and rights to purchase restricted stock to eligible recipients. Recipients of stock options are eligible to purchase shares of theCompany’s common stock at an exercise price equal to no less than the estimated fair market value of such stock on the date of grant. The maximum term ofoptions granted under the 2006 Plan is ten years. Options granted pursuant to the 2006 Plan generally vest over four years. Upon adoption of the 2010 Plandiscussed below, no further grants may be made from the 2006 Plan.In 2010, the Company adopted the 2010 Equity Incentive Award Plan (the “2010 Plan”), which became effective immediately prior to the completionof the IPO. An initial 280,459 shares were reserved for issuance to employees, directors and consultants of the Company under the 2010 plan. The number ofshares initially reserved were subsequently increased by the number of shares of common stock related to awards granted under the 2006 Plan that arerepurchased, forfeited, expired or are canceled on or after the effective date of the 2010 Plan, as well as an annual increase pursuant to an evergreen provision.The 2010 Plan provides for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock units and rights topurchase restricted stock to eligible recipients. Recipients of stock options are eligible to purchase shares of the Company’s common stock at an exerciseprice equal to no less than the estimated fair market value of such stock on the date of grant. The maximum term of options granted under the 2010 Plan is tenyears.Service-based options granted pursuant to the 2010 Plan generally vest over four years. Performance-based options are subject to the employee’scontinued service and become vested and exercisable based on the completion of a specified regulatory milestone.In June 2012, the Company amended and restated the 2010 Plan (the “Restated 2010 Plan”). Pursuant to the Restated 2010 Plan, the number of sharesthat are reserved for issuance under the 2010 Plan was increased to 1,162,500, plus any shares related to outstanding options granted under the 2006 Plan thatare repurchased, forfeited, expire or are canceled on or after the effective date of the Restated 2010 Plan. Further, the 2010 Plan’s evergreen provision wasamended such that, commencing on January 1, 2013, and on each January 1 thereafter during the term of the Restated 2010 Plan, the aggregate number ofshares available for issuance under the Restated 2010 Plan shall be increased by that number of shares of the Company’s common stock equal to the lower of:•4% of the Company’s outstanding common stock on the applicable January 1; or•an amount determined by the board of directors.At December 31, 2017 and 2016, 756,524 and 571,778 shares of common stock were available for future issuance under the Restated 2010 Plan,respectively.On December 4, 2013, the Company adopted the Employment Inducement Equity Incentive Award Plan (the Inducement Plan). The terms of theInducement Plan are substantially similar to the terms of the Company’s 2010 Equity Incentive Award Plan with two principal exceptions: (1) incentive stockoptions may not be granted under the Inducement Plan; and (2) the annual compensation paid by the Company to specified executives will be deductibleonly to the extent that it does not exceed $1.0 million, as the conditions of Section 162(m) of the Internal Revenue Code of 1986, as amended (“IRC”)applicable at the time will not be met. The Inducement Plan was adopted by the board of directors without stockholder approval pursuant to Rule 5635(c)(4)of the Nasdaq Listing Rules.The Company has initially reserved 337,500 shares of the Company’s common stock for issuance pursuant to awards granted under the InducementPlan. In accordance with Rule 5635(c)(4) of the Nasdaq Listing Rules, awards under the Inducement Plan may only be made to an employee who has notpreviously been an employee or member of the board ofF- 24Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)directors of the Company or any parent or subsidiary, or following a bona fide period of non-employment by the Company or a parent or subsidiary, if he orshe is granted such award in connection with his or her commencement of employment with the Company or a subsidiary and such grant is an inducementmaterial to his or her entering into employment with the Company or such subsidiary. As of December 31, 2017 and 2016, there were 102,276 and 236,625shares of common stock available for future issuance under the Inducement Plan, respectively.The 2006 Plan, Restated 2010 Plan and Inducement Plan are intended to encourage ownership of stock by employees, consultants and non-employeedirectors of the Company, as applicable, and with respect to the 2006 Plan and Restated 2010 Plan, to provide additional incentives for them to promote thesuccess of the Company’s business. The board of directors is responsible for determining the individuals to receive equity grants, the number of sharessubject to each grant, the exercise price per share and the exercise period of each option. The Company satisfies option exercises through the issuance of newshares.The following sections summarize activity under the Company’s stock plans.Stock OptionsThe following table summarizes the Company’s stock option activity for 2017: Shares(in thousands) WeightedAverageExercisePrice WeightedAverageRemainingContractualTerm (years) AggregateIntrinsicValue(in thousands)Outstanding at December 31, 20163,285 $15.46 Granted961 $11.07 Exercised(677) $15.47 Canceled(177) $11.79 Outstanding at December 31, 20173,392 $14.41 7.2 $86,987Exercisable at December 31, 20172,003 $16.53 6.3 $47,116The total intrinsic value of options exercised in 2017, 2016 and 2015 was $14.3 million, $24,000 and $0.3 million, respectively. In 2017, the Company determined the achievement of the performance condition for certain options granted in October 2015 was no longer consideredprobable, and previously recognized compensation costs of $0.7 million were reversed.Restricted Stock UnitsThe following table summarizes the Company’s restricted stock unit activity for 2017: Shares(in thousands) Weighted AverageFair Value perShare at GrantDateNonvested at December 31, 2016103 $10.31Granted175 10.42Vested— —Canceled(19) 9.60Nonvested at December 31, 2017259 10.43F- 25Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)As of December 31, 2017, restricted stock units (“RSUs”) outstanding include 159,000 shares granted in March 2017 with performance-basedconditions to employees and executives. The weighted average fair value of RSUs granted was $10.20 per share. The RSUs vest upon the approval by theFDA of the Company’s new drug application for ZX008, provided such approval occurs within five years following the grant date. Due to the uncertaintiesassociated with the FDA approval process, approval is not yet probable, as such term is used for accounting purposes, prior to the occurrence of the event.Accordingly, no compensation expense has been recognized as of December 31, 2017 for these awards.There were no vestings of restricted stock units in 2017, 2016 and 2015. As of December 31, 2017, nonvested restricted stock units outstanding notsubject to a performance condition had a weighted average remaining contractual term of 0.2 years with an intrinsic value of $3.9 million.Employee Stock Purchase PlanIn 2010, the Company adopted the 2010 Employee Stock Purchase Plan (the “ESPP”), which allows employees to purchase shares of the Company’scommon stock during specified offering periods at a discount to the fair market value at the time of purchase. The ESPP is implemented by overlapping,twelve-month offering periods and each offering period may contain up to two purchase periods of six months each. At any one time, there may be up to twooffering periods under the ESPP. In general, a new twelve-month offering period commences on each June 1 and December 1 of a calendar year.Stock may be purchased under the ESPP at a price equal to 85% of the fair market value of the Company’s stock on either the date of purchase or thefirst day of an offering period, whichever is lower. Eligible employees may elect to withhold up to 20% of their compensation through payroll deductionsduring an offering period for the purchase of stock. The ESPP contains a reset provision whereby if the price of the Company’s common stock on the first dayof a new offering period is less than the price on the first day of any preceding offering period, all participants in the preceding offering period with higherfirst day price will be automatically withdrawn from such offering periods and re-enrolled in the new offering period. The reset feature, when triggered, will beaccounted for as a modification to the original offering period, resulting in incremental expense to be recognized over the twelve-month period of the newoffering.The ESPP limits the maximum number of shares that may be purchased by any one participant in an offering period to 2,500 shares. In addition, theIRC limits purchases under an ESPP to $25,000 worth of stock in any one calendar year, valued as of the first day of the offering period.At December 31, 2017 and 2016, a total of 16,672 and 21,356 shares of common stock were reserved for issuance under the ESPP, respectively. In 2017,2016 and 2015 35,934, 35,164, and 25,204 shares were issued under the ESPP, respectively.Valuation of Equity AwardsThe Company used the Black-Scholes option-pricing model for determining the estimated fair value and stock-based compensation for stock-basedawards to employees and the board of directors. The assumptions used in the Black-Scholes option-pricing model were as follows: Year Ended December 31, 2017 2016 2015Stock Options Risk free interest rate1.8% to 2.3% 1.1% to 2.1% 1.5% to 1.9%Expected term5.1 to 6.1 years 5.1 to 6.1 years 5.1 to 6.1 yearsExpected volatility75.1% to 85.8% 76.5% to 78.1% 76.7% to 79.2%Expected dividend yield—% —% —%Weighted-average fair value of option on grant date$7.43 $6.69 $8.37 Employee Stock Purchase Plan Risk free interest rate1.1% to 1.6% 0.5% to 0.8% 0.1% to 0.5%Expected term0.5 to 1.0 years 0.5 to 1.0 years 0.5 to 1.0 yearsExpected volatility54.8% to 152.8% 59.5% to 71.3% 67.4% to 77.8%Expected dividend yield—% —% —%The risk-free interest rate assumption was based on the rates for U.S. Treasury zero-coupon bonds with maturities similar to those of the expected termof the stock option or purchase right being valued. The assumed dividend yield was zero as theF- 26Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)Company currently does not intend to pay dividends in the foreseeable future. The weighted average expected term of options was calculated using thesimplified method as prescribed by accounting guidance for stock-based compensation due to the Company’s limited history of relevant stock optionexercise activity. The expected volatility was calculated based on the Company’s historical stock prices, supplemented as necessary with historical volatilityof the common stock of several peer companies with characteristics similar to those of the Company.Stock-Based Compensation ExpenseThe Company recognized stock-based compensation expense in continuing operations as follows (in thousands): Year Ended December 31, 2017 2016 2015Cost of contract manufacturing$71 $386 $390Research and development1,933 1,924 1,266Selling, general and administrative4,151 5,043 5,285Total$6,155 $7,353 $6,941As of December 31, 2017, there was approximately $9.2 million of total unrecognized compensation costs related to outstanding equity awardsscheduled to be recognized over a weighted average period of 2.3 years.11. Employee Benefit PlanEffective February 1, 2007, the Company established a defined contribution 401(k) plan (the Plan) for all employees who are at least 21 years of age.Employees are eligible to participate in the Plan beginning on the first day of the month following one month of employment. Under the terms of the Plan,employees may make voluntary contributions as a percentage of compensation. The Plan also provides the Company to make discretionary matchingcontributions. In 2017 and 2016, the Company made discretionary matching contributions of $0.2 million and $0.1 million, respectively. In 2015, nodiscretionary contributions were made.12. Income TaxesThe Company recognizes liabilities for uncertain tax positions based on a two-step process. The first step is to evaluate the tax position for recognitionby determining if the weight of available evidence indicates it is more likely than not that the position will be sustained on audit, including resolution ofrelated appeals or litigation processes, if any. The second step is to measure the tax benefit as the largest amount which is more than 50% likely of beingrealized upon ultimate settlement. There were no unrecognized tax benefits included in the balance sheet at December 31, 2017 and 2016, that would, ifrecognized, affect the tax rate.The following table summarizes the activity related to the Company’s unrecognized tax benefits (in thousands): December 31, 2017 2016 2015Beginning balance of unrecognized tax benefits$1,248 $1,132 $1,019Gross increases based on tax positions related to current year633 116 113Gross increases based on tax positions related to prior year149 — —Settlements with taxing authorities— — —Expiration of statute of limitations— — —Ending balance of unrecognized tax benefits$2,030 $1,248 $1,132If the unrecognized tax benefits as of December 31, 2017 were reversed, there would be no effect on the Company’s effective tax rate as the tax benefitwould increase a deferred tax asset, which is currently offset with a full valuation allowance.The Company recognizes interest and, if applicable, penalties related to income tax matters as income tax expense. No interest or penalties have beenrecorded for all periods presented. The Company does not expect any significant increases or decreases to its unrecognized tax benefits in the next twelvemonths.F- 27Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)For financial reporting purposes, the components of loss from continuing operations before income taxes were as follows (in thousands): December 31, 2017 2016 2015United States$(32,112) $(24,285) $(40,845)Foreign(93,910) (45,349) (16,760)Total$(126,022) $(69,634) $(57,605)At December 31, 2017, the Company’s federal, state, and foreign income tax net operating loss carryforwards were approximately $254.4 million,$192.6 million and $135.7 million, respectively, which may be subject to limitations as described below. If not utilized, the federal tax loss carryforwardswill begin to expire in 2026 and the state tax loss carryforwards will begin to expire in 2016. Under the newly enacted federal income tax law, federal netoperating losses incurred in 2018 and in future years may be carried forward indefinitely, but the deductibility of such federal net operating losses is limited.It is uncertain if and to what extent various states will conform to the newly enacted federal income tax law. In addition, the Company has federal andCalifornia research and development income tax credit carryforwards of $3.3 million and $4.0 million, respectively. If not utilized, the federal research anddevelopment income tax credit carryforwards will begin to expire in 2026. The California research and development income tax credit carryforwards do notexpire and can be carried forward indefinitely. Due to the net operating loss carryforwards, all years remain open for income tax examination by taxauthorities in the United States, various states and foreign tax jurisdictions in which the Company files tax returns.The Company is in the process of completing an analysis under Internal Revenue Service Code (“IRC”) Sections 382 and 383 to determine if theCompany’s net operating loss carryforwards and research and development credits are limited due to a change in ownership. As of December 31, 2017, theCompany has experienced at least three ownership changes. The first ownership change occurred in August 2006 upon the issuance of the Series A-1convertible preferred. As a result of this ownership change, the Company has reduced its net operating loss carryforwards by $1.9 million and research anddevelopment income tax credits by $8,000. The Company had a second ownership change as defined by IRC Sections 382 and 383, which occurred inSeptember 2011 upon the issuance of common stock in its follow-on offering. As a result of the second ownership change, the Company has reduced itsfederal net operating loss carryforwards as of December 31, 2011 by $121.1 million and research and development income tax credits as of December 31,2011 by $3.0 million. The Company also reduced its California net operating loss carryforwards as of December 31, 2011 by $53.3 million as a result of thesecond ownership change. The Company had a third ownership change as defined by IRC Sections 382 and 383, which occurred in January 2014. There wasno forfeiture of federal and California net operating loss carryforwards or research and development income tax credits as a result of the third ownershipchange. The Company may have experienced an ownership change during 2017 and believes that any such ownership change is not expected to furtherreduce its federal net operating loss or research and development credit carryforwards. Pursuant to IRC Section 382 and 383, use of the Company’s netoperating loss and research and development income tax credit carryforwards may be limited in the event of a future cumulative change in ownership of morethan 50% within a three-year period.F- 28Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)A reconciliation of the Company’s income tax benefit from continuing operations compared to the income tax benefit computed at the Federalstatutory tax is was as follows (in thousands): December 31, 2017 2016 2015Income tax at 34% federal statutory rate$(42,846) $(23,675) $(19,586)State taxes, net of federal benefit(19) (65) (691)Change in valuation allowance(11,208) 16,024 (14,042)U.S. statutory tax rate change36,085 — —Valuation allowance adjustment for continuing operations— — 15,498Permanent interest disallowed(150) (1,832) 375Foreign rate change - Impact on Deferred Taxes1,619 521 (1,993)Other permanent differences5,774 1,307 114Research and development tax credits(274) (145) (1,060)State tax rate benefit56 578 2,181Foreign rate differential10,636 6,122 2,550Credits and other327 217 753Income tax benefit$— $(948) $(15,901)ASC 740-20 requires total income tax expense or benefit to be allocated among continuing operations, discontinued operations, extraordinary items,other comprehensive income and items charged directly to shareholders’ equity. This allocation is referred to as intra-period tax allocation. As a result of thegain recognized in discontinued operations from the sale of the Company’s Zohydro ER business to Pernix in 2015, ASC 740-20-45-7 required us to allocatea tax expense to discontinued operations and a tax benefit to continuing operations. The amount of income tax expense recorded as part of discontinuedoperations is limited to the tax benefit from income from continuing operations. Accordingly, the Company has recorded a tax expense of $14.1 million in2015 in discontinued operations and a corresponding income tax benefit from continuing operations. The remaining tax benefit to continuing operationsprimarily relates to tax rate reductions enacted in the U.K. in November 2015, which resulted in a decrease to deferred tax liability.On December 22, 2017, the Tax Cuts and Jobs Act (the “Tax Act”) was enacted into legislation, which includes a broad range of provisions affectingbusinesses. The Tax Act contains, among other things, significant changes to corporate taxation, including reduction of the corporate tax rate from a topmarginal rate of 35% to a flat rate of 21% for tax years beginning after December 31, 2017, limitation of the deduction for net operating losses to 80% ofcurrent year taxable income and elimination of net operating loss carrybacks, implementing a territorial tax system, and requiring a mandatory one-time taxon U.S. owned undistributed foreign earnings and profits known as the transition tax.Pursuant to SAB 118, an entity may select between one of three scenarios to determine a reasonable estimate arising from the Tax Act. The scenarios are(i) a final estimate which effectively closes the measurement window; (ii) a reasonable estimate leaving the measurement window open for future revisions;and (iii) no estimate as the law is still being analyzed. The Company was able to provide a reasonable estimate for the revaluation of deferred taxes and theeffects of the transition tax on undistributed foreign earnings and profits. As such, the Company has recorded a $36.1 million reduction in deferred tax assetsfor the revaluation of deferred taxes which was offset by a corresponding decrease to the Company’s full valuation allowance. The reduction in deferred taxassets included provisional amounts to account for changes to IRC Section 162(m) and the impacts of the transition tax on the Company’s net operatinglosses. Additional work is necessary for a more detailed analysis of the impacts of the Tax Act. Any subsequent adjustment to these amounts will be recordedto current tax expense in the quarter of 2018 when the analysis is complete.Significant components of the Company’s deferred tax assets are presented below. A valuation allowance of $101.1 million and $112.3 million as ofDecember 31, 2017 and 2016, respectively, has been established against the deferred tax assets for which it is more likely than not that the tax benefit willnot be realized.F- 29Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued) December 31, 2017 2016Deferred tax assets: Net operating losses$87,142 $90,543Capitalized research and development2,155 4,504Accrued expenses1,310 1,240Research and development credits5,282 4,596Accrued product returns— 34Inventory reserve and UNICAP— 175Amortization630 1,680Depreciation163 1,533Deferred revenue— 475Other, net4,432 7,542Total deferred tax assets101,114 112,322Less valuation allowance(101,114) (112,322)Net deferred tax assets— — Deferred tax liabilities: IPR&D(17,425) (17,425)Total deferred tax liabilities(17,425) (17,425)Net deferred tax liability$(17,425) $(17,425)On December 31, 2015, the California Supreme Court overturned the California Appellate court decision on The Gillette Company et al. v. CaliforniaFranchise Tax Board. The court held that the taxpayers couldn’t elect an evenly weighted, three-factor apportionment formula pursuant to the Multistate TaxCompact, or MTC. The Company had elected the three-factor apportionment formula pursuant to the MTC for 2013 and 2014. As a result of the CaliforniaSupreme Court decision, the Company has reduced its deferred tax assets and offsetting valuation allowance related to the California NOL calculated in 2013and 2014 pursuant to the MTC election.The Company’s income tax expense related to taxable income generated by its wholly-owned subsidiary, Zogenix Europe Limited were not materialfor all years presented. In addition, the Company recorded income tax benefit of zero, $1.0 million and $2.1 million in 2017, 2016 and 2015, respectively,related to the operations of its other wholly-owned subsidiary, Zogenix International Limited.The Company carries out extensive research and development activities that may benefit from the UK’s small and medium-sized enterprise (“SME”)research and development tax credit regime, whereby the Company may either receive an enhanced UK tax deduction on its research and developmentactivities or a refundable cash credit. Where an entity is in a net operating loss position under the SME regime, it can surrender a portion of the losses thatarise from its research and development activities in return for a refundable cash credit. These refundable cash credits, which may be received without regardto actual tax liability, are not subject to accounting for income taxes and will be recorded as a component of other income if realized. As of December 31,2017, the Company had filed a claim for a refundable cash credit for its 2015 tax year of up to $3.1 million. The Company has not recorded a receivable forthis refundable cash credit at December 31, 2017 as collectability was deemed not probable or reasonably assured.F- 30Table of ContentsZogenix, Inc.Notes to Consolidated Financial Statements (continued)13. Summarized Quarterly Data (Unaudited)The following financial information reflects all adjustments, which includes all normal recurring adjustments and the items described in (1) to (2)below, which are, in the opinion of management, necessary for a fair statement of the consolidated financial results of the interim periods. Summarizedquarterly data for 2017 and 2016 is as follows: 2017 Quarter Ended March 31 June 30 (1) September 30 (1) December 31 (1) (in thousands, except per share amounts)Revenue$2,696 $7,125 $— $—Loss from continuing operations$(21,126) $(22,453) $(42,660) $(39,783)(Loss) income from discontinued operations$(181) $(555) $(134) $75Net loss$(21,307) $(23,008) $(42,794) $(39,708)Net loss per share, basic and diluted$(0.86) $(0.93) $(1.68) $(1.17) 2016 Quarter Ended March 31 June 30 September 30 December 31(2) (in thousands, except per share amounts)Revenue$9,206 $2,088 $6,570 $10,986Loss from continuing operations$(10,220) $(18,246) $(16,618) $(23,602)(Loss) income from discontinued operations$(169) $(582) $(379) $109Net loss$(10,389) $(18,828) $(16,997) $(23,493)Net loss per share, basic and diluted$(0.42) $(0.76) $(0.69) $(0.95)(1)In April 2017, the Company completed fulfillment of the remaining open orders under its manufacturing and supply agreement with Endo and theCompany no longer has a source of recurring revenue.(2)Net loss from continuing operations included asset impairment charges of $8.4 million for long-lived assets and prepaid royalties associated with theproduction of Sumavel DosePro (See Note 6).F- 31Table of ContentsEXHIBIT INDEX Incorporated by Reference ExhibitNo. Description Form File Number Date of Filing ExhibitNo. FiledHerewith 2.1† Sale and Purchase Agreement dated October 24, 2014 by and amongthe Registrant, Zogenix Europe Limited, Brabant Pharma Limitedand Anthony Clarke, Richard Stewart, Ann Soenen-Darcis,Jennifer Watson, Rekyer Securities plc and Aquarius Life ScienceLimited, as sellers 8-K/A 001-34962 December 23, 2014 10.1 2.2† Asset Purchase Agreement, dated March 10, 2015, by and amongthe Registrant, Pernix Ireland Limited and Pernix TherapeuticsHoldings, Inc. 8-K/A 001-34962 August 18, 2015 2.1 2.3† Amendment to Asset Purchase Agreement, dated April 23, 2015, byand among the Registrant, Pernix Ireland Limited and PernixTherapeutics Holdings, Inc. 8-K 001-34962 April 28, 2015 2.2 3.1 Fifth Amended and Restated Certificate of Incorporation S-1/A 333-169210 October 27, 2010 3.5 3.2 Certificate of Amendment of Fifth Amended and Restated Certificateof Incorporation 10-Q 001-34962 November 8, 2012 3.2 3.3 Certificate of Amendment of Fifth Amended and Restated Certificateof Incorporation 10-Q 001-34962 August 10, 2015 3.3 3.4 Amended and Restated Bylaws S-1/A 333-169210 October 27, 2010 3.7 4.1 Form of the Registrant’s Common Stock Certificate S-1/A 333-169210 November 4, 2010 4.1 4.2 Warrant dated June 30, 2008 issued by the Registrant to CITHealthcare LLC (subsequently transferred to The CIT Group/EquityInvestments, Inc.) S-1 333-169210 September 3, 2010 4.6 4.3 Transfer of Warrant dated March 24, 2009 from CIT Healthcare LLCto The CIT Group/Equity Investments, Inc. S-1 333-169210 September 3, 2010 4.7 4.4 Warrant dated July 18, 2011 issued by the Registrant to CowenHealthcare Royalty Partners II, L.P. 10-Q 001-34962 August 12, 2011 4.12 10.1 Form of Director and Executive Officer Indemnification Agreement S-1/A 333-169210 October 27, 2010 10.1 10.2# 2006 Equity Incentive Plan, as amended, and forms of optionagreements thereunder S-1 333-169210 September 3, 2010 10.3 10.3# 2010 Equity Incentive Award Plan and forms of option and restrictedstock agreements thereunder S-1/A 333-169210 October 27, 2010 10.5 10.4# 2010 Employee Stock Purchase Plan and form of Offering documentthereunder S-1/A 333-169210 October 27, 2010 10.6 10.5# Form of Restricted Stock Unit Award Agreement under the 2010Equity Incentive Award Plan 10-Q 001-34962 August 8, 2013 10.1 10.6# Employment Inducement Equity Incentive Award Plan and form ofstock option agreement thereunder 8-K 001-34962 December 5, 2013 10.1 10.7# Annual Incentive Plan 10-Q 001-34962 May 11, 2015 10.3 10.8# Independent Director Compensation Policy as amended and restatedeffective March 8, 2016 10-Q 001-34962 May 10, 2016 10.2 10.9# Amended and Restated Employment Agreement, dated April 27,2015, by and between the Registrant and Stephen J. Farr, Ph.D. 10-Q 001-34962 August 10, 2015 10.4 10.10# Employment Agreement, dated June 29, 2015, by and between theRegistrant and Gail M. Farfel, Ph.D. 10-Q 001-34962 August 10, 2015 10.5 Table of Contents Incorporated by Reference ExhibitNo. Description Form File Number Date of Filing ExhibitNo. FiledHerewith 10.11# Employment Agreement dated December 17, 2013 by and betweenthe Registrant and Bradley S. Galer, M.D. 10-K 001-34962 March 7, 2014 10.44 10.12# Employment Agreement dated January 16, 2017, by and between theRegistrant and Michael P. Smith 10-Q 001-34962 May 4, 2017 10.2 10.13# General Release of Claims dated January 16, 2017, by and betweenRegistrant and Ann D. Rhoads 10-Q 001-34962 May 4, 2017 10.1 10.14# Settlement Agreement dated November 22, 2017, by and between theRegistrant and Thierry Darcis X 10.15† Collaboration and License Agreement dated as of October 23, 2014by and among The Katholieke Universiteit Leuven, UniversityHospital Antwerp and Brabant Pharma Limited 10-Q 001-34962 November 6, 2014 10.5 10.16 Lease dated October 31, 2006 by and between the Registrant andEmery Station Joint Venture, LLC S-1 333-169210 September 3, 2010 10.10 10.17 First Amendment to Lease dated July 10, 2007 by and between theRegistrant and Emery Station Joint Venture, LLC S-1 333-169210 September 3, 2010 10.11 10.18 Second Amendment to Lease dated October 20, 2009 by andbetween the Registrant and Emery Station Joint Venture, LLC S-1 333-169210 September 3, 2010 10.12 10.19 Third Amendment to Office Lease, dated July 20, 2015, by andbetween the Registrant and Emery Station Joint Venture, LLC 10-Q 001-34962 August 10, 2015 10.8 10.20 Office Lease dated August 5, 2014 by and between the Registrantand Kilroy Realty, L.P. 10-Q 001-34962 November 6, 2014 10.6 10.21 Controlled Equity Offering Sales Agreement, dated May 10, 2016,by and between the Registrant and Cantor Fitzgerald & Co. S-3 333-211265 May 10, 2016 1.2 21.1 Subsidiaries of the Company 10-K 001-34962 March 10, 2017 21.1 23.1 Consent of Independent Registered Public Accounting Firm X 31.1 Certification of Chief Executive Officer pursuant to Section 302 ofthe Public Company Accounting Reform and Investor ProtectionAct of 2002 (18 U.S.C. §1350, as adopted) X 31.2 Certification of Chief Financial Officer pursuant to Section 302 ofthe Public Company Accounting Reform and Investor ProtectionAct of 2002 (18 U.S.C. §1350, as adopted) X 32.1 Certification of Chief Executive Officer pursuant to Section 906 ofthe Public Company Accounting Reform and Investor ProtectionAct of 2002 (18 U.S.C. §1350, as adopted) X 32.2 Certification of Chief Financial Officer pursuant to Section 906 ofthe Public Company Accounting Reform and Investor ProtectionAct of 2002 (18 U.S.C. §1350, as adopted) X Table of Contents Incorporated by Reference ExhibitNo. Description Form File Number Date of Filing ExhibitNo. FiledHerewith101 The following financial statements from Zogenix, Inc.’s AnnualReport on Form 10-K for the year ended December 31, 2017, filedon March 5, 2018, formatted in XBRL: (i) Consolidated BalanceSheets, (ii) Consolidated Statements of Operations; (iii)Consolidated Statements of Comprehensive (Loss) Income, (iv)Consolidated Statements of Cash Flows, and (v) the Notes toConsolidated Financial Statements. X† Confidential treatment has been granted or requested, as applicable, for portions of this exhibit. These portions have beenomitted from the Registration Statement and filed separately with the Securities and Exchange Commission# Indicates management contract or compensatory plan.Table of ContentsSIGNATURESPursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to besigned on its behalf by the undersigned, thereunto duly authorized. ZOGENIX, INC. Date: March 6, 2018 By:/s/ Stephen J. Farr President and Chief Executive Officer Date: March 6, 2018 By:/s/ Michael P. Smith Executive Vice President, Chief FinancialOfficer, Treasurer and SecretaryPursuant to the requirements of the Securities Exchange Act of 1934, as amended, this report has been signed below by the following persons on behalfof the Registrant and in the capacities and on the dates indicated. Signature Title Date/S/ STEPHEN J. FARR, PH.D. President and Chief Executive Officer (Principal Executive Officer) March 6, 2018Stephen J. Farr, Ph.D. /S/ MICHAEL P. SMITH Executive Vice President, Chief Financial Officer, Treasurer andSecretary (Principal Financial and Accounting Officer) March 6, 2018Michael P. Smith /S/ CAM L. GARNER Chairman of the Board March 6, 2018Cam L. Garner /S/ LOUIS C. BOCK Director March 6, 2018Louis C. Bock /S/ JAMES B. BREITMEYER, M.D., Ph.D. Director March 6, 2018James B. Breitmeyer, M.D., Ph.D /S/ ROGER L. HAWLEY Director March 6, 2018Roger L. Hawley /S/ ERLE T. MAST Director March 6, 2018Erle T. Mast /S/ RENEE TANNENBAUM, Pharm.D. Director March 6, 2018Renee Tannenbaum, Pharm.D. /S/ MARK WIGGINS Director March 6, 2018Mark Wiggins Date: November 22, 2017ZOGENIX INTERNATIONAL LIMITEDTHIERRY DARCIS SETTLEMENT AGREEMENT London99 BishopsgateLondon EC2M 3XF(44) 020 7710 1000 (Tel)(44) 020 7374 4460 (Fax)www.lw.comContact: Gus Fung iSETTLEMENT AGREEMENTWITHOUT PREJUDICE AND SUBJECT TO CONTRACTTHIS AGREEMENT is made on 22nd of November 2017BETWEEN(1)ZOGENIX INTERNATIONAL LIMITED, a company registered in England with registered number 08330213 and havingits registered office at Siena Court, Broadway, Maidenhead,England, SL6 1NJ (the “Company”); and(2)Thierry Darcis, residing at Blair Lodge, 318 Reading Road, Wallingford OX10 9DW (the “Employee”).BACKGROUND(A)The Employee’s employment with the Company will terminate by reason of redundancy at the Termination Date;(B)The Employee believes he has the Claims (as that term is defined below) arising out of the termination of his employment orotherwise;(C)The parties have entered into this Agreement for the purposes of recording and implementing the terms that they have agreedas full and final settlement of the Claims and any and all other claims that the Employee has and/or may have against theCompany and any Group Company (as defined below) whether or not they are or could be in the contemplation of the partiesat the date of this Agreement;(D)The parties agree that the conditions regulating settlement agreements under the Acts (as defined below) are satisfied by thisAgreement; and(E)The Company is entering into this Agreement for itself and for all Group Companies, and is duly authorised to do so in thatrespect.IT IS AGREED as follows:1.DEFINITIONS AND INTERPRETATION1.1DefinitionsIn this Agreement, unless the context otherwise requires:“the Acts”means the Employment Rights Act 1996 section 203(3), the Equality Act 2010,section 147 and the Working Time Regulations 1998 regulation 35(2)(b).“Claims”means the claims that the Employee believes that he has against the Company or anyGroup Company or against any of its or their respective shareholders, officers,employees or agents, being:(i) for breach of contract arising out of his employment, or termination of theemployment, or otherwise;(ii) for unfair dismissal under the Employment Rights Act 1996; 1SETTLEMENT AGREEMENT (iii) in relation to unauthorised deductions from wages;(iv) for working time or holiday pay under the Working Time Regulations1998;(v) for discrimination, harassment or victimisation on the grounds of age, sex,race or nationality or any other unlawful ground, pursuant to the EqualityAct 2010;(vi) for breach of contract or any other rights to or in respect of shares or othersecurities or securities based incentives (individually and together “ShareIncentives”) in the Company or any Group Company;(vii) for unlawful detriment under the Employment Rights Act 1996; and(viii) under the Public Interest Disclosure Act 1998.“Employment Contract”means the Employee’s terms and conditions of employment with an effectivedate of 29 June 2015.“Group”means the Company, any presently existing or future holding company orundertaking of the Company and any presently existing or future subsidiariesand subsidiary undertakings of the Company or such holding company orundertaking (and the words “subsidiary” and “holding company” shall havethe meanings given to them in section 1159 in the Companies Act 2006).“Group Company”means any company within the Group.“Schedule”means a schedule to this Agreement.“Termination Date”means 22 November 2017.1.2Interpretation and ConstructionSave to the extent that the context or the express provisions of this Agreement require otherwise, in this Agreement:(a)words importing the singular shall include the plural and vice versa;(b)words importing any gender shall include all other genders;(c)references to any statute or statutory provision (including any subordinate legislation) include any statute or statutoryprovision which amends, extends, consolidates or replaces the same, or which has been amended, extended,consolidated or replaced by the same, and shall include any orders, regulations, instruments or other subordinatelegislation made under the relevant statute or statutory provision;(d)references to a “person” includes any individual, firm, company, corporation, body corporate, government, state oragency of state, trust or foundation, or any association, partnership or unincorporated body (whether or not havingseparate legal personality) or two or more of the foregoing; 2SETTLEMENT AGREEMENT(e)general words shall not be given a restrictive meaning because they are followed by words which are particularexamples of the acts, matters or things covered by the general words and “including”, “include” and “in particular”shall be construed without limitation; and(f)the words “other” and “otherwise” shall not be construed eiusdem generis with any foregoing words where a widerconstruction is possible.1.3HeadingsThe headings in this Agreement are included for convenience only and shall be ignored in construing the Agreement.2.TERMINATION OF EMPLOYMENT AND OFFICES2.1The employment of the Employee with the Company will terminate on the Termination Date.2.2This Agreement constitutes written notice from the Company of termination of the Employee’s employment.2.3The Employee will resign forthwith in terms of the draft letter set out at Schedule 1 confirming his resignation from hisemployment and from all directorships and other offices which the Employee holds in the Company and the Group.2.4The Employee will do all such acts and things as the Company may require to effect his resignation from all other offices towhich the Employee was appointed in connection with or by reason of his employment by or appointment with the Companyor any Group Company, including all trusteeships.3.PAYMENTS3.1Subject to compliance by the Employee with the terms of this Agreement, the Company will (without admission of liability)pay to the Employee the following sums (the “Severance Payments”):(a)£1,467 as a statutory redundancy payment, calculated as follows: the Employee’s age is 54, length of service is 2 years,therefore entitlement is 3 weeks’ pay at £489 (the statutory cap per week);(b)£108,000 as an ex gratia payment in compensation for the termination of his employment;(c)£19,763.30 as a payment in lieu of notice;(d)£220,690.20 as a contractual redundancy payment;(e)£4,800 as a payment equal to the monthly plan premium for 12 months for the Employee and his eligible dependentswho were covered under the Company’s health plans as at the Termination Date; and(f)£100 in respect of the undertakings given in Clause 11 in this Agreement.3.2The Severance Payments will be paid within 14 days after the later to occur of:(a)the Termination Date; and 3SETTLEMENT AGREEMENT(b)receipt by the Company of this Agreement duly executed by the Employee and his solicitor.3.3Subject to compliance by the Employee with the terms of this Agreement, the Company will also (without admission ofliability) pay to the Employee a sum equivalent to any Bonus (as defined in the Employment Contract) to which the Employeeis eligible if there is a Change of Control (as defined in the Employment Contract) within sixty days after the Termination Date(the “Change of Control Payment”).3.4The Change of Control Payment will be paid within 14 days after the later to occur of:(a)receipt by the Company of this Agreement duly executed by the Employee and his solicitor; and(b)the relevant Change of Control.3.5The Severance Payments and Change of Control Payment set out above are gross amounts and will be made after deduction ofall payments or deductions required by law or owed by the Employee to the Company or any Group Company, including taxdue on any benefits or payments made or to be made to the Employee in respect of his employment with the Company.3.6On receipt of a written request from a potential employer, the Company shall provide a factual reference limited to confirmingthe dates of employment and position held. Any oral reference provided will be on the same terms.4.TAXATION4.1The Company gives no warranty as to how the Severance Payments and Change of Control Payment should be taxed. TheCompany understands that the aggregate of the first £30,000 of the Severance Payments under Clauses 3.1(a) and 3.1(b) willnot be subject to tax, pursuant to chapter 3 of part 6 of the Income Tax (Earnings and Pensions) Act 2003, but the aggregate ofthe Severance Payments under Clauses 3.1(a) and 3.1(b) in excess of £30,000 and the Severance Payments under Clauses3.1(c), 3.1(d), 3.1(e) and 3.1(f) and the Change of Control Payment (if any) (together the “Taxable Amount”) will be subject todeduction by the Company of tax at the appropriate rate and (other than for the Severance Payments under Clauses 3.1(a) and(b)) employee’s National Insurance contributions before payment is made to the Employee. The Company will account toHMRC for the tax and National Insurance contributions deducted.4.2The Employee will be responsible and liable for the payment of any tax and employee’s National Insurance contributions andany social security contributions and other employment related taxes wherever in the world arising (including any interest,penalties, costs and expenses) due in respect of the Severance Payments and the benefits and incentives (if any) set out in thisAgreement (excluding the tax and National Insurance contributions deducted by the Company from the Taxable Amount) (the“Additional Tax”). The Employee will indemnify the Company and each Group Company and keep them indemnified on acontinuing basis against all and any liability for Additional Tax that the Company or any Group Company may incur. Nopayment of Additional Tax will be made to HMRC or other relevant authority without first particulars of the proposed paymentbeing given to the Employee so that he is given the opportunity at his own expense to dispute any such payment or liabilitywith HMRC or other relevant authority.5.PAYMENT OF ACCRUED SUMS AND EXPENSES5.1The Company will pay the Employee salary in respect of the period up to the Termination Date and pay in lieu of holidaywhich has accrued in the period up to the Termination Date. 4SETTLEMENT AGREEMENT5.2The Employee will submit his final expenses claim made up to the Termination Date, within 5 days after the date of thisAgreement. The Company will reimburse the Employee for all expenses reasonably incurred in the proper performance of hisduties in the usual way.5.3The Employee accepts he is not entitled to and will not be paid any commission or bonus (other than as may become duepursuant to Clause 3.3).6.STOCK INCENTIVES/SHARES6.1As at the Termination Date, the Employee will hold 162,500 of shares subject to stock options (that have been granted atvarious different exercise prices) under the Zogenix, Inc. 2010 Equity Incentive Plan (the “Options”). On the TerminationDate, the Options (save for those granted in October 2015 and the restricted stock unit awards granted in March 2015) willaccelerate and vest to provide the Employee with the number of Shares subject to Options that he would have received had heremained employed with the Company for another twelve months following the Termination Date. The Employee will havethree months from the Termination Date to exercise the Options. On the day that is three months after the Termination Date anyunexercised vested Options will lapse and cease to be exercisable.6.2The Employee has been granted 8,750 Restricted Stock Units under the Zogenix, Inc. 2010 Equity Incentive Plan. All of theseRestricted Stock Units are unvested and will lapse on the Termination Date.6.3The terms of the Zogenix, Inc. 2010 Equity Incentive Plan will continue to govern the Options and Restricted Stock Units.7.LEGAL COSTS7.1Subject to receipt by the Company of the signed certificate at Schedule 2, the Company will make a contribution of £500(excluding VAT) towards the reasonable legal costs incurred by the Employee for the advice received regarding thetermination of his employment and entering into this Agreement.7.2Payment of this sum will be made directly to the Employee’s solicitors by the Company within 14 days after receipt by theCompany of a copy of the VAT invoice from the Employee’s solicitors (which should be addressed to the Employee butmarked as payable by the Company).8.WARRANTIES8.1The Employee warrants that:(a)he has not raised any legal proceedings against the Company or any Group Company or against any of its or theirrespective shareholders, officers, employees or agents; and(b)other than the Claims, he has no further or outstanding claims or rights of action, being any further or outstandingclaims or rights of action, whether under statute or common law (including contractual, tortious or other claims) andwhether before an Employment Tribunal, court or otherwise and whether in the UK or any other jurisdiction in theworld against the Company or any Group Company or any of its or their respective shareholders, officers, employeesor agents including in respect of or arising out of his employment, or the holding of any office with, the Company orany Group Company or the termination of that employment or office (such claims or rights of action referred to as“Further Claims”).8.2The Employee warrants as a strict condition to payment under this Agreement that there are no circumstances of which he isaware or of which he ought to be aware which could constitute a 5SETTLEMENT AGREEMENTrepudiatory breach by him of his contract of employment which would entitle or have entitled the Company to terminate hisemployment without notice.9.SETTLEMENT9.1The Employee accepts the terms of this Agreement in full and final settlement of the Claims and all and any Further Claims,whether such claims are known or unknown to the parties and whether or not they are or could be in the contemplation of theparties at the date of this Agreement, which are waived and released in full.9.2The Employee undertakes not to institute or pursue any proceedings against the Company or any Group Company or againstany of its or their respective shareholders, officers, employees or agents before an Employment Tribunal, court or any otherjudicial body anywhere in the world in respect of the Claims or for any remedy arising from any Further Claims.9.3The Employee does not waive his right to bring a claim for accrued rights under any pension scheme or damages for latentpersonal injuries and/or any latent industrial disease arising out of the course of his employment with the Company and/or theGroup that are currently unknown to him. The Employee warrants that he is not aware of having any such personal injuries.These exceptions are the only claims which have not been settled by this Agreement.9.4Subject to the terms of Clause 9.3, if any other claim emerges in law or in fact anywhere in the world which was not previouslyknown or foreseeable by the Employee in relation to his employment or holding of office or termination of that employment oroffice, then the Employee agrees that there should be no recourse to any remedy for the claim against the Company or anyGroup Company. The Employee acknowledges and accepts that in agreeing to the level of the Severance Payments he hastaken into account that he has waived the right to pursue any claims, whether foreseeable or not previously known, against theCompany or any Group Company.10.ACKNOWLEDGEMENTThe Employee acknowledges that the Company has entered into this Agreement and made the Severance Payments in relianceon the warranties and the undertakings given by him in Clause 8 and Clause 9, respectively. In the event of any breach by theEmployee of any of those warranties or undertakings, the Severance Payments shall be repaid by him to the Companyimmediately and shall be recoverable by the Company as a debt.11.CONFIDENTIALITY11.1The Employee agrees he continues to owe a duty of confidentiality to the Company and to the Group after the TerminationDate.11.2The Employee undertakes to keep confidential the existence and terms of this Agreement and that he will not disclose the sameto any other person unless expressly authorised by the Company, save for the purposes of:(a)seeking legal advice in relation to its terms;(b)disclosing the same to the proper authorities as required by law;(c)disclosing to any actual or prospective employer with the prior written permission of the Board of the Company that hisemployment with the Company terminated by reason of redundancy upon terms which remain confidential; and(d)disclosing the terms of this Agreement to his spouse/civil partner provided that on so doing the Employee imposesupon him/her a like condition of confidentiality. 6SETTLEMENT AGREEMENT11.3The Employee undertakes not to do any act or thing that might reasonably be expected would damage the business, interests orreputation of the Company or any Group Company, and will not make or publish or cause to be made or published to anyonein any circumstances any disparaging remarks concerning the Company or any Group Company or any of its or theirrespective shareholders, officers, employees or agents.11.4Neither the Company nor any Group Company will authorise anyone to make or publish or cause to be made or published toanyone any statement or do any act or thing which it or they might reasonably expect would damage the interests or reputationof the Employee.11.5The Employee acknowledges and agrees that, whilst the consideration paid pursuant to Clause 3.1(f) represents valuableconsideration, it does not amount to an estimate of or cap on the loss or damage which the Company or any Group Companywould suffer were the Employee to breach any of the obligations set out in this Clause.12.DELIVERY UP12.1The Employee will return to the Company’s premises on or before the Termination Date all books, documents, papers, data(including copies or extracts and whether in printed or electronic format), materials, mobile phones, personal electronicdevices, computer and peripherals and security codes, credit cards, keys, security cards, or other property of or relating to thebusiness of the Company or the Group or its or their respective clients or suppliers.12.2The Employee confirms that he has not retained any confidential information relating to the Company or the Group, whetherstored in electronic format or otherwise.13.STATUTORY SETTLEMENTThis Agreement is made in compliance with the Acts which have been satisfied both generally and in the following particulars:(a)the Employee confirms that he has received independent legal advice on the terms and effect of this Agreement, and inparticular its effect on his ability to pursue his rights before an Employment Tribunal or court;(b)the said legal advice has been given to the Employee by Daff Richardson of Pennington Manches LLP whose address is9400 Garsington Road, Oxford Business Park, Oxford,OX4 2HN; and(c)the said solicitor has confirmed to the Employee that she is a qualified solicitor holding a current practising certificateand in respect of whom there is in force a policy of professional indemnity insurance covering the risk of a claimagainst her and the said firm in respect of loss arising in consequence of the said advice and by signing this Agreementalso confirms that she complies with the Acts.14.EMPLOYMENT CONTRACTThe Employee confirms that all clauses in his Employment Contract with the Company that are described as applying after thetermination of his employment, including the restrictions set out in clause 6, will continue to apply to him.15.COUNTERPARTSThis Agreement may be executed in any number of counterparts, including facsimiles, each of which is an original and all ofwhich together evidence the same agreement. 7SETTLEMENT AGREEMENT16.GOVERNING LAW AND JURISDICTION16.1This Agreement is governed and to be construed in accordance with English law and any dispute is subject to the exclusivejurisdiction of the English courts.16.2Any Group Company may enjoy the benefit of and enforce the terms of this Agreement in accordance with the provisions ofthe Contracts (Rights of Third Parties) Act 1999.The “without prejudice” and “subject to contract” nature of this document shall cease to apply once executed by the parties. 8SETTLEMENT AGREEMENTSCHEDULE 1 - RESIGNATIONThe DirectorsZogenix International Limited Siena CourtBroadway, Maidenhead EnglandSL6 1NJ22 November 2017 Gentlemen,Zogenix International Limited (the “Company”)I hereby resign with immediate effect as an employee and from my office as a director of the Company and from all other officeswhich I hold in any Group Company.Yours faithfully/s/ Thierry Darcis Thierry Darcis 9SETTLEMENT AGREEMENTSCHEDULE 2 - CERTIFICATE OF INDEPENDENT LEGAL ADVISERI Daff Richardson of Pennington Manches LLP whose address is 9400 Garsington Road, Oxford Business Park, Oxford, OX4 2HNconfirm that I gave independent legal advice to Thierry Darcis as to the terms and effect of the Agreement to which this certificate isattached (including the effect of Clauses 8, 9 and 10) and in particular its effect on his ability to pursue his rights before a Court orEmployment Tribunal.I confirm that I am a solicitor of the Senior Courts holding a current practising certificate and that the statutory requirements relating tosettlement agreements and compromise agreements set out in the Acts (as defined in the Agreement) have been met. Further, that therewas in force at the time I gave the advice referred to above a policy of insurance covering the risk of a claim by Thierry Darcis inrespect of any loss arising in consequence of that advice.Signed:/s/ Daff Richardson Daff Richardson Dated:23/17/11 10SETTLEMENT AGREEMENTIN WITNESS of which this document has been executed as a deed by the parties on the date shown at the beginning of thisdocument.SIGNED byZOGENIX INTERNATIONAL LIMITEDacting by STEPHEN FARR/s/ Stephen Farr SIGNED by THIERRY DARCIS Witness’s:Signature:/s/ Susan Hanan /s/ Thierry Darcis Full Name:Susan Hanan Thierry Darcis Address: Blair Lodge Reading Rd Wallingford OX10 9DW UK 11SETTLEMENT AGREEMENTExhibit 23.1Consent of Independent Registered Public Accounting FirmWe consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-170875, No. 333-181543, No. 333-197998) pertaining tothe 2006 Equity Incentive Plan of Zogenix, Inc., the 2010 Equity Incentive Award Plan and 2010 Employee Stock Purchase Plan of Zogenix, Inc., the 2010Equity Incentive Award Plan, as amended of Zogenix Inc., the Employment Inducement Equity Incentive Award Plan of the Zogenix, Inc., and theRegistration Statements on Form S-3 (No. 333-220759, No. 333-185900) of Zogenix, Inc. and in the related Prospectuses, as applicable, of our reports datedMarch 6, 2018, with respect to the consolidated financial statements of Zogenix, Inc., and the effectiveness of internal control over financial reporting ofZogenix, Inc., and to the reference to our firm under the captions “Risk Factors” included in this Annual Report (Form 10-K) for the year ended December 31,2017./s/ Ernst & Young LLP Redwood City, CaliforniaMarch 6, 2018Exhibit 31.1CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Stephen J. Farr, certify that:1.I have reviewed this Annual Report on Form 10-K of Zogenix, Inc. for the fiscal year ended December 31, 2017;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light ofthe circumstances under which such statements were made, not misleading with respect to the period covered by this report;3.Based on my knowledge, the consolidated financial statements, and other financial information included in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that materialinformation relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period inwhich this report is being prepared;b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to providereasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generallyaccepted accounting principles;c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of thedisclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (theregistrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal controlover financial reporting; and5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors andthe audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adverselyaffect the registrant’s ability to record, process, summarize and report financial information; andb)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financialreporting. /s/ Stephen J. FarrStephen J. FarrPresident and Chief Executive OfficerDate: March 6, 2018Exhibit 31.2CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002I, Michael P. Smith, certify that:1.I have reviewed this Annual Report on Form 10-K of Zogenix, Inc. for the fiscal year ended December 31, 2017;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light ofthe circumstances under which such statements were made, not misleading with respect to the period covered by this report;3.Based on my knowledge, the consolidated financial statements, and other financial information included in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that materialinformation relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period inwhich this report is being prepared;b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to providereasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generallyaccepted accounting principles;c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of thedisclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; andd)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (theregistrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal controlover financial reporting; and5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors andthe audit committee of the registrant’s board of directors (or persons performing the equivalent functions):a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adverselyaffect the registrant’s ability to record, process, summarize and report financial information; andb)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financialreporting. /s/ Michael P. SmithMichael P. SmithChief Financial OfficerDate: March 6, 2018Exhibit 32.1CERTIFICATIONPursuant to Section 906 of the Sarbanes-Oxley Act of 2002(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)In connection with the Annual Report on Form 10-K of Zogenix, Inc. (the “Company”) for the period ended December 31, 2017, as filed with the Securities andExchange Commission on the date hereof (the “Report”), I, Stephen J. Farr, as Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adoptedpursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. Date:March 6, 2018 /s/ Stephen J. Farr Stephen J. Farr Chief Executive OfficerThe foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the SecuritiesExchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of anygeneral incorporation language in such filing. A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by theCompany and furnished to the Securities and Exchange Commission or its staff upon request.Exhibit 32.2CERTIFICATIONPursuant to Section 906 of the Sarbanes-Oxley Act of 2002(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)In connection with the Annual Report on Form 10-K of Zogenix, Inc. (the “Company”) for the period ended December 31, 2017, as filed with the Securities andExchange Commission on the date hereof (the “Report”), I, Michael P. Smith, as Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adoptedpursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. Date:March 6, 2018 /s/ Michael P. Smith Michael P. Smith Chief Financial OfficerThe foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the SecuritiesExchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of anygeneral incorporation language in such filing. A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by theCompany and furnished to the Securities and Exchange Commission or its staff upon request.

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