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Akari Therapeutics Plc

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FY2016 Annual Report · Akari Therapeutics Plc
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AKARI THERAPEUTICS PLC  

CONSOLIDATED ANNUAL REPORT AND FINANCIAL STATEMENTS 

FOR THE YEAR ENDED  

31 DECEMBER 2016 

Registered Number: 05252842 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

CONSOLIDATED ANNUAL REPORT AND FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2016 

CONTENTS 

Officers and professional advisers 

Directors’ report 

Strategic Report 

Director’s Remuneration Report 

Independent Auditors’ report to the shareholders of Akari Therapeutics Plc 

Consolidated statement of comprehensive loss 

Consolidated statement of financial position 

Parent company statement of financial position 

Consolidated statement of changes in equity 

Consolidated statement of cash flows 

Parent company statement of cash flows 

Page 

1 

2 – 3 

4 – 8 

9-17 

18 

19 

20 

21 

22 

23 

24 

Notes to the report and financial statements 

25-37 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

OFFICERS AND PROFESSIONAL ADVISERS 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Directors 

Secretary 

Registered Office 

Independent Auditors 

G Roshwalb 
R Prudo-Chlebosz  
C Richardson  
J Hill  
S Ungar  
D Byrne 
R Ward   
D Williams  

SLC Corporate Services Limited 
R Shaw (appointed 23 March 2016) 

42-50 Hersham Road 
Walton-On-Thames, 
Surrey 
KT12 1RZ 

haysmacintyre 
26 Red Lion Square 
London  
WC1R 4AG 

1 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Unless  the  context  otherwise  requires,  all  references  to  “Akari,”  “we,”  “us,”  “our,”  the  “Company”,  the  “Group”  and 
similar designations refer to Akari Therapeutics, Plc and its subsidiaries. 

The directors present their report and the audited financial statements for the year ended 31 December 2016. 

PRINCIPAL ACTIVITY  

The  principal  activity  of  the  Group  is  developing  inhibitors  of  acute  and  chronic  inflammation,  specifically  the 
complement system, the eicosanoid system and the bioamine system for the treatment of rare and orphan diseases. 

DIRECTORS 

The directors who served the company during the year and up to the date of signing the Annual Report were as follows: 

M Cohen (resigned 13 October 2016) 
G Roshwalb 
A Shaw (resigned 29 June 2016) 
R Prudo-Chlebosz  
C Richardson  
J Hill  
S Ungar  
D Byrne (appointed 20 April 2016) 
R Ward (appointed 13 October 2016) 
D Williams (appointed 29 June 2016) 

SUPPLIER PAYMENT POLICY 

It  is  the  Group’s  policy  to  agree  to  commercial  terms  with  its  suppliers  prior  to  purchase  of  goods  or  services.      The 
Group negotiates favourable payment terms where possible. 

CORPORATE GOVERNANCE 

The Group is not required to implement the provisions of the UK Corporate Governance Code (the “Code”).  

Regular  board  meetings  are  held  and  the  Executive  Directors  are  heavily  involved  in  the  day  to  day  running  of  the 
business.    The  Board  of  Directors  meets  regularly  and  is  responsible  for  formulating  strategy,  monitoring  financial 
performance and approving material items of expenditure. 

GOING CONCERN 

The  Group  meets  its  day-to-day  working  capital  requirements  through  funding.  The  competiveness  in  the  market 
conditions continue to create uncertainty particularly over the level of demand for the Group’s research and development 
activities, product candidates and products and the availability of funding for the foreseeable future. The Group’s forecast 
and projections, taking account of reasonably possible changes in trading performance and market conditions, show that 
the Group should be able to operate within the level of its current liabilities. After making enquiries, the Directors have a 
reasonable expectation that the Group has sufficient funding and adequate resource to continue operationally for at least 
12 months from the date of this Annual Report.  The Group therefore continues to adopt the going concern basis for the 
preparation of the consolidated financial statements. 

2 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

STATEMENT OF DIRECTORS’ RESPONSIBILITIES  

The Directors are responsible for preparing the Annual Report and the financial statements in accordance with applicable 
laws and regulations. 

Company law requires the directors to prepare group and parent company financial statements for each financial year. Under 
that  law  the  directors  are  required  to  prepare  the  group  financial  statements  in  accordance  with  International  Financial 
Reporting  Standards  (“IFRS”) as  adopted  by  the  EU.    Under  company  law  the  Directors  must  not  approve the  financial 
statements unless they are satisfied that they give a true and fair view of the state of affairs of the Group and the Company 
and the profit or loss of the Group for that period. 

The Group financial statements are required by law and IFRSs as adopted by the EU to present fairly the financial position 
and performance of the group; the Companies Act 2006 provides in relation to such financial statements that references in 
the  relevant  part  of  that  Act  to  financial  statements  giving  a  true  and  fair  view  are  references  to  their  achieving  a  fair 
presentation. The parent company financial statements are required by law to give a true and fair view of the state of affairs 
of the parent company. 

In preparing these financial statements the directors are required to: 
 
 
 

select suitable accounting policies and then apply them consistently; 
make judgements and accounting estimates that are reasonable and prudent; 
state  whether  they  have  been  prepared  in  accordance  with  IFRS  as  adopted  by  the  EU  subject  to  any  material 
departures disclosed and explained in the financial statements;  and 
prepare the financial statements on the going concern basis unless it is inappropriate to presume that the Group and 
the parent company will continue in business. 

 

The directors are responsible for keeping proper accounting records which disclose with reasonable accuracy at any time 
the financial position of the Group and parent company and to enable them to ensure that the financial statements comply 
with the Companies Act 2006 and Article 4 of the IAS Regulation.  They have general responsibility for taking such steps 
as are reasonably open to safeguard the assets of the Group and parent company and to prevent and detect fraud and  
other irregularities.  

The  Directors consider that the Annual Report, taken as  a whole, is fair, balanced and understandable and provides the 
information necessary for shareholders to assess the Group’s performance, business model and strategy.  

DISCLOSURE OF INFORMATION TO AUDITORS 

So far as each of the directors is aware at the time the report is approved: 
 
 

there is no relevant audit information of which the Groups’s auditors are unaware; and 
the  directors  have taken all  steps  that they  ought  to have taken  to  make  themselves  aware  of  any  relevant  audit 
information and to establish that the auditors are aware of that information 

This report was approved by the board on 15 May 2017 
and signed on its behalf. 

Dr. R Prudo                                                                                           
Executive Chairman 

3 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2016 

REVIEW OF BUSINESS 

We are a clinical-stage biopharmaceutical company focused on developing inhibitors of acute and chronic inflammation, 
specifically the complement system, the eicosanoid system and the bioamine system for the treatment of rare and orphan 
diseases. Each of these systems has scientifically well-supported causative roles in the diseases being targeted by us. We 
believe that blocking early mediators of inflammation will prevent initiation and continual amplification of the processes 
that cause certain diseases. 

Ticks  have  undergone  300  million  years  of  natural  selection  to  produce  inhibitors  that  bind  tightly  to  key  highly-
conserved  inflammatory  mediators,  are  generally  well  tolerated in  humans,  and  remain  fully  functional  when  a  host  is 
repeatedly exposed to the molecule. Our molecules are derived from these inhibitors. 

Our  lead  product  candidate,  Coversin™,  which  is  a  second-generation  complement  inhibitor,  acts  on  complement 
component-C5,  preventing  release  of  C5a  and  formation  of  C5b–9  (also  known  as  the  membrane  attack  complex,  or 
MAC),  and  independently  also  inhibits  LTB4  activity,  both  elements  that  are  co-located  as  part  of  the 
immune/inflammatory response. Coversin is a recombinant small protein (16,740 Da) derived from a protein originally 
discovered  in  the  saliva  of  the  Ornithodoros  moubata  tick,  where  it  modulates  the  host  immune  system  to  allow  the 
parasite to feed without alerting the host to its presence or provoking an immune response. 

Coversin has received orphan drug status from the  U.S. Food and Drug  Administration, or the FDA, and the European 
Medicines Agency, or the EMA, for paroxysmal nocturnal haemoglobinuria, or PNH, and  Guillain Barré Syndrome, or 
GBS.  Orphan  drug  designation  provides  us  with  certain  benefits  and  incentives,  including  a  period  of  marketing 
exclusivity if regulatory approval of the drug is ultimately received for the designated indication. The receipt of orphan 
drug  designation  status  does  not  change  the  regulatory  requirements  or  process  for  obtaining  marketing  approval  and 
designation does not mean that marketing approval will be received. We intend to apply in the future for further orphan 
drug designation in indications we deem appropriate. We have also received fast track designation for the investigation of 
Coversin for treatment of PNH in patients who have polymorphisms conferring eculizumab resistance. 

Our initial clinical targets for Coversin are PNH, atypical Hemolytic Uremic Syndrome, or aHUS, and GBS. We are also 
targeting patients with polymorphisms of the C5 molecule which interfere with correct binding of Soliris® (eculizumab), 
a  first-generation  C5  inhibitor  currently  approved  for  PNH  and  aHUS  treatment,  making  these  patients  resistant  to 
treatment  with  that  drug.  In  addition  to  disease  targets  where  complement  dysregulation  is  the  key  driver,  we  are  also 
targeting a range of inflammatory diseases where the inhibition of both C5 and LTB4 are implicated. 

Other  compounds  in  our  pipeline  include  engineered  versions  of  Coversin  that  potentially  decrease  the  frequency  of 
administration, improve potency, or allow for specific tissue targeting, as well as new proteins targeting LBT4 alone, as 
well as bioamine inhibitors (for example, anti-histamines). In general, these inhibitors act as ligand binding compounds, 
which may provide additional benefit versus other modes of inhibition. For example, off target effects are less likely with 
ligand capture. One example of this benefit is seen with LTB4 inhibition through ligand capture. LTB4 acts to amplify 
the inflammatory signal by bringing and activating white blood cells to the area of inflammation. Compounds that have 
targeted the production of leukotrienes will inhibit both the production of pro-inflammatory as well as anti-inflammatory 
leukotrienes—often diminishing the potential benefit of the drug on the inflammatory system. Coversin has demonstrated 
that,  by  capturing  LTB4,  it  is  limited  to  disrupting  the  white  blood  cell  activation  and  attraction  aspects,  without 
interfering with the anti-inflammatory benefits of other leukotrienes. 

Coversin  is  much  smaller  than  typical  antibodies  currently  used  in  therapeutic  treatment.  Coversin  can  be  self-
administered  by  subcutaneous  injection,  much  like  an  insulin  injection,  which  we  believe  will  provide  considerable 
benefits  in  terms  of  patient  convenience.  We  believe  that  the  subcutaneous  formulation  of  Coversin  may  accelerate 
recruitment for our clinical trials, and, as an alternative to intravenous infusion, may accelerate patient uptake if Coversin 
is  approved  by  regulatory  authorities  for  commercial  sale.  Patient  surveys  contracted  by  us  suggest  that  a  majority  of 
patients would prefer to self-inject daily than undergo intravenous infusions. 

Information about the interim analysis of our ongoing Phase II PNH trial and other matters can be found in our Report on 
Form 6-K filed with the Securities and Exchange Commission on April 24, 2017. 

As previously reported by us in our public filings with the Securities and Exchange Commission, on 27 April 2017, we 
issued  a  press  release  stating  that  Edison  Investment  Research  Ltd.  has  withdrawn  its  report  issued  26  April  2017  titled  “Akari’s 
Coversin matches Soliris in Phase II” (the “Edison Report”) because it contains material inaccuracies, including without 
limitation, with respect to our recently announced interim analysis of its ongoing Phase 2 PNH trial of Coversin.  

4 

 
 
 
 
 
 
  
  
 
 
  
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Investors were cautioned not to rely upon any information contained in the Edison Report and instead were directed to 
our press release issued on 24 April 2017 that discusses the interim analysis of its ongoing Phase 2 PNH trial and other 
matters. Our Board of Directors has established an ad hoc special committee of the Board to review the involvement, if 
any,  of  our  personnel  with the Edison  Report.    While  that  review  is  pending,  Dr.  Gur  Roshwalb,  our  Chief  Executive 
Officer,  has  been  placed  on  administrative  leave  and  Dr.  Ray  Prudo  in  his  role  as  Executive  Chairman  is  temporarily 
assuming Dr. Roshwalb’s duties in his absence. 

On  12  May  2017,  a  putative  securities  class  action  captioned  Derek  Da  Ponte  v.  Akari  Therapeutics,  PLC,  Gur 
Roshwalb,  and Dov Elefant (Case 1:17-cv-03577) was filed in the U.S. District Court for the Southern District of New 
York  against  the  Company,  the  Company’s  Chief  Executive  Officer  and  the  Company’s  Chief  Financial  Officer.   The 
plaintiff  asserted  claims  alleging  violations  of  Sections  10(b)  and  20(a)  of  the  Securities  Exchange  Act  of  1934  based 
primarily  on  the  Company’s  above  referenced  press  release  issued  on  27  April  2017.   The  purported  class  covers  the 
period from 30 March 2017 to 11 May 2017.  The action seeks unspecified damages and costs and fees.  The Company 
intends  to  vigorously  defend  itself  against  this  lawsuit.    At  this  time,  the  Company  is  unable  to  estimate  the  ultimate 
outcome of this legal matter and its impact on the Company. 

RESULTS AND DIVIDENDS 

Research and development expenses for the year ended 31 December 2016  were $17,306,000 (2015: $5,799,000). This 
$11,507,000 increase was due to higher expenses of $8,175,000 for manufacturing, $1,859,000 for clinical trial expenses, 
$914,000  for  consulting  expense,  $576,000  for  personnel  expenses,  $221,000  for  regulatory  expenses,  $119,000  for 
toxicology studies and $119,000 for stock-based non-cash compensation expense offset by a research and development 
tax credit of $578,000. 

Administrative  expenses  for  the  year  ended  31  December  2016  were  $9,941,000  (2015:  $5,502,000).  This  $4,439,000 
increase  was  primarily  due  to  higher  expenses  of  $2,851,000  for  stock-based  non-cash  compensation  expense, 
$1,480,000  of  personnel  expenses,  $564,000  of  board  expenses  and  $356,000  of  rent  expenses,  offset  by  $750,000  of 
compensation  expense  in  2015.  Net  cash  used  in  operating  activities  for  the  year  ended  31  December  2016  was 
$24,614,000  (2015:  $4,967,000).  Net  cash  flow  used  in  operating  activities  was  primarily  attributed  to  our  ongoing 
research activities to support Coversin, including manufacturing, clinical trial and preclinical activities. 

Net cash used in investing activities for the year ended 31 December 2016 was $10,067,000 (2015: net cash received of 
$1,533,000). This is cash used to purchase office equipment and short-term investments offset by maturities of short-term 
securities. 

Cash, cash equivalents, and short term investments decreased to approximately $44,263,000 at 31 December 2016 (2015: 
$69,062,000).    

The  Group  made  a  loss  of  $26,224,000  (2015:  $29,607,000).    The  loss  for  the  Group  is  in  line  with  the  expected 
performance and the Directors are satisfied with the results for the year. 

No dividends were paid during the year (2015: $Nil) and the directors do not propose a final dividend. 

5 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

PRINCIPAL RISKS AND UNCERTAINTIES 

Financing 
The  Group’s  main  risk  is  obtaining  additional  funding  when  required  to  continue  its  future  operations  and  planned 
research  and  development  activities.      The  Directors  recognise  that  the  Group  may  not  be  able  to  obtain  financing  on 
favourable  terms  and  the  terms  of  the  Group’s  finance  arrangements  may  be  dilutive.    The  Group  may  also  seek 
additional  funding  through  arrangements  with  collaborators  and  other  third  parties.    These  type  of  arrangements  may 
require the Group to relinquish rights to internally  developed technology, product candidates or products.  If the Group 
was unable to obtain additional funding on a timely basis, the Group may be required to curtail or terminate some or all 
of its research or development programs, including some or all of its product candidates. 

Early stage development 
The Group is an early stage development Group with limited history of trading on which future projections can be based.  
There  is  no  guarantee  that  the  Group  will  succeed  in  growing  its  current  business  or  that  the  Group  will  be  able  to 
provide or maintain sufficient resources required for operations in the development and introduction of its products.  A 
large majority of early stage development companies fail to achieve their business plans mainly due to lack of being able 
to estimate the speed of new market entrants and the costs associated with entering markets and obtaining market share. 

Drug development 
The  Group’s  approach  to  drug  development  is  complex  and  all  of  the  product  candidates  are  in  an  early  stage  of 
development with a high risk of failure.  It is impossible to predict when or if any of the product candidates will prove 
effective or safe in humans or will receive regulatory approval. 

Further common challenges for similar companies and the Group is to: 

  Find a stable active product or formulation without extensive clinical trials and substantial additional 

costs or create adequate assay for the products for formulation or clinical testing purposes; 

  Manufacture, and/or formulate sufficient amounts of its product candidates or upscale or optimise such 

synthesis so as to enable efficient production of scale; 

  Find safe and effective doses and dose ratios for its product candidates without extensive clinical trials 

and substantial additional costs; 

  Obtain sufficient supply or quality of product candidates supply or materials to produce product 

candidates or other materials necessary to conduct clinical trials; and 

  Establish manufacturing capabilities  or enter into agreements  with third  parties to supply materials to 

make product candidates, or manufacture clinical trial drug supplies. 

6 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

PRINCIPAL RISKS AND UNCERTAINTIES (CONTINUED) 

Market acceptance 
The Group is not guaranteed that any of its product candidates will gain market acceptance amongst physicians, patients, 
healthcare providers, pharmaceutical companies or other customers. 

The Group’s clinical trials in humans may show that the doses or dose ratios selected based on screening, animal testing 
or early clinical trials do not achieve the desired therapeutic result in humans, or achieve these results only in a small part 
of the population.  The U.S.  Food and Drug  Administration  (“FDA”)  or  other regulatory  agencies in the United States 
and foreign jurisdictions may determine that these clinical trials do not support the Group’s conclusion.  The Group may 
be  required  to  conduct  additional  long-term  clinical  studies  and  provide  more  evidence  substantiating  the  safety  and 
effectiveness of the doses or dose ratios selected in a significant patient population. 

Intense competition from powerful competitors 
Many  companies,  universities  and  research  organisations  developing  product  candidates  have  greater  resources  and 
significantly greater experience in financial, research and development, manufacturing, marketing, sales, distribution and 
technical  regulatory  matters  than  the  Group  has.    These  competitors  could  commence  and complete  clinical  testing  of 
their  products,  obtain  regulatory  approval,  and  begin  commercial-scale  manufacturing  of  their  products  faster  than  the 
Group is able to, thus resulting in a situation whereby the Group may not be able to commercialise its product candidates 
or achieve a competitive position in the market. 

Product liability exposure 
The Group faces exposure to product liability and other claims if its product candidates, products or processes are alleged 
to have caused harm.  These risks are inherent in testing, manufacturing, and marketing human therapeutic products.  If 
the  Group  is  sued  for  any  injury  caused  by  its  products,  product  candidates  or  processes,  the  Group’s  liability  could 
exceed its product liability insurance coverage and its total assets.  Claims against the Group, regardless of their merit or 
potential outcome, may also generate negative publicity or damage the Group’s ability to obtain physician endorsement 
of its products or expand its business. 

Intellectual Property 
The Group may be unable to protect the intellectual property relating to its product candidates, or if it infringes the rights 
of  others,  its  ability  to  successfully  commercialise  its  product  candidates  may  be  harmed.    The  Group  owns  or  hold 
licenses to a number of issued patents (foreign and foreign counterparts) and pending patent applications.  The Group’s 
success  depends in part on its ability to obtain  patent protection both in the United States and in  other countries for its 
product candidates, as well as the methods for treating patients in the product indications using these product candidates. 
The  Group’s  ability  to  protect  its  product  candidates  from  unauthorised  or  infringing  use  by  third  parties  depends  in 
substantial  part  on  its  ability  to  obtain  and  maintain  valid  and  enforceable  patents.  Due  to  evolving  legal  standards 
relating to the patentability,  validity  and enforceability  of patents covering  pharmaceutical  inventions and the  scope of 
claims  made under these  patents,  the  Group’s  ability  to  obtain,  maintain and  enforce  patents is uncertain and involves 
complex legal and factual questions. Even if the Group’s product candidates, as well as methods for treating patients for 
prescribed indications using these product candidates are covered by valid and enforceable patents and have claims with 
sufficient scope, disclosure and support in the specification, the patents will provide protection only for a limited amount 
of  time.  Accordingly,  rights  under  any  issued  patents  may  not  provide  the  Group  with  sufficient  protection  for  a 
commercial advantage against competitive products or processes 

Liquidity and Public Listing 
Historically, a limited public market exists for the Group’s securities and it cannot assure that its securities will continue 
to be listed on the NASDAQ Capital Market or any other securities exchange or that an active trading market will ever 
develop for any  of its securities. The Group’s  ADSs  were approved for listing on the  NASDAQ  Capital Market on  31 
January  2014.  The  Group  cannot  assure  that  it  will  be  successful  in  meeting  the  continuing  listing  standards  of  the 
NASDAQ  Capital  Market.  Consequently,  the  trading  liquidity  of  its  ADSs  may  not  improve.  The  Group  may  not  be 
successful in maintaining the listing of its ADSs on the NASDAQ Capital Market and cannot assure that its ADSs will be 
listed on a national securities exchange. There is no assurance that an active trading market for its ADSs will develop or 
if such a market develops that it will be sustained. 

7 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

FINANCIAL INSTRUMENTS 

The Group finances its operations using cash generated by the sale of equity instruments in the Group.  The cash flow of 
the Group is monitored on a regular basis to ensure the Group has sufficient funding to meet its capital and operational 
requirements. 

RESEARCH AND DEVELOPMENT 

The  Group  is  a  clinical-stage  biopharmaceutical  company  focused  on  developing  inhibitors  of  acute  and  chronic 
inflammation, specifically the complement system, the eicosanoid system and the bioamine system for the treatment of 
rare and orphan diseases. 

KEY PERFORMANCE INDICATORS  

The  Directors  consider  the  key  performance  indicators  to  be  the  research  and  development  spend.    This  allows  the 
Directors to manage the on-going activities and strategies for further development of the Group.  

The key performance indicators are measured and reviewed on a regular basis at Board meetings and enable the Directors 
to communicate the performance of the Group against predetermined targets.  

Key financial performance indicators:  

Research and Development spend - $17,306,000 (2015: $5,799,000) 
Cash, cash equivalents and short term investments position - $44,263,000 (2015: $69,062,000) 

This report was approved by the board on 15 May 2017 and signed on its behalf. 

Dr. R Prudo                                                                                           
Executive Chairman 
15 May 2017 

8 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT  

FOR THE YEAR ENDED 31 DECEMBER 2016 

PART I - ANNUAL REPORT ON REMUNERATION 

Information provided in this section of the Directors’ Remuneration report is subject to audit.  

Single Total Figure of Remuneration for Each Director (subject to audit) 

The following table shows the compensation paid or accrued during the fiscal year ended 31 December 2016. 

Name of Director 

Salary 
and Fees 
($) 

Taxable 
Benefits 
($) 

Bonus 
($) 

Stock 
Awards 
($) 

Option 
Awards 
($)(1) 

Pension 
Benefits 
($) 

2016 Total 
($) 

Executive Director 
Ray Prudo(2) 
Gur Roshwalb, M.D 

200,000 
375,000 

- 
28,925 
(3) 
8,757 (5) 

150,000 
187,500 

129,167 

282,178 

Clive Richardson 
Non-Employee Director 
James Hill, M.D 
Stuart Ungar, M.D 
David Byrne (7) 
Donald Williams (8) 
Robert Ward (9) 
Mark S. Cohen(10) 
Allan Shaw (11) 

58,249 
50,770 
21,683 
25,500 
10,880 
60,749 
25,290 

- 
- 
- 
- 
- 
- 
- 

- 
- 
- 
- 
- 
- 
- 

- 
- 

- 

- 
- 
- 
- 
- 
- 
- 

- 
- 

- 

- 
18,750(4) 

350,000 
581,250 

33,225(6) 

446,160 

126,226 
126,226 
278,636 
248,898 
69,062 
195,287 
- 

- 
- 
- 
- 
- 
- 
- 

184,475 
176,996 
300,319 
274,398 
79,942 
256,036 
25,290 

(1) These amounts represent the aggregate grant date fair value for option awards for fiscal year 2016 computed in accordance with FASB ASC Topic 
718.  A discussion of  the assumptions used in determining  grant date fair  value may  be  found in  Akari’s  Financial  Statements,  included  in Akari’s 
Annual Report on Form 20-F for the year ended 31 December 2016. 

(2) Dr. Prudo is party to a non-executive contract although he performs executive duties on behalf of Akari. 

(3) Consists of company contributions to health benefits. 

(4) Consists of company contributions to a 401K plan. 

(5) Consists of company contributions to health benefits of $7,167 and life insurance premiums of $1,590. 

(6) Consists of company contributions to a pension plan. 

(7) Mr. Byrne was appointed to the board as a Class A director on 20 April 2016. 

(8) Mr. Williams was appointed to the board as a Class A director on 30 June 2016. 

(9) Mr. Ward was appointed to the board as a Class A director on 13 October 2016. 

(9) Mr. Cohen resigned as a Class C director on 13 October 2016. In connection with Mr. Cohen’s resignation, Akari and Mr. Cohen agreed that Mr. 
Cohen’s (i) outstanding unvested stock options from 25 November 2015 and 29 June 2016 in the amounts of 1,028,722 and 1,300,000 ordinary shares, 
respectively, shall be fully vested as of 13 October 2016, and (ii) vested options (including those whose vesting accelerated pursuant to the preceding 
clause) shall continue to be exercisable for a period ending on the earlier of (1) 10 years following the respective dates of grant of such options, or (2) 
three months following Akari’s 2018 AGM. In addition, Akari agreed to (i) grant Mr. Cohen an additional option to purchase 1,300,000 fully vested 
ordinary shares (equivalent to 13,000 ADS) at an exercise price of $0.080621 per share (or $8.0621 per ADS) and which can be exercised until three 
months following the 2018 AGM, and (ii) pay Mr. Cohen, in quarterly instalments, $45,750 for the balance of director fees that he would have earned 
through the 2017 AGM and an additional $61,000 that he would have earned in director fees from the 2017 AGM to the 2018 AGM. 

(10) Mr. Shaw’s term as a Class A director expired on 29 June 2016. As of 31 December 2016, all previously granted options to Mr. Shaw expired 
without exercise. 

The following table shows the compensation paid or accrued during the fiscal year ended 31 December 2015. 

Name of Director 

Salary 
and Fees 
($) 

Taxable 
Benefits 
($) 

Bonus 
($) 

Stock 
Awards 
($) 

Option 
Awards 
($)(1) 

Pension 
Benefits 
($) 

2015 Total 
($) 

Executive Director 
Ray Prudo (2) 
Gur Roshwalb, M.D 
Clive Richardson 
Non-employee Director 
James Hill, M.D 

56,986 
357,292 
79,792 

- 
31,429(4) 
1,660(5) 

- 
86,625 
- 

17,381 

- 

- 

- 
6,863,034 
3,431,517 

- 
- 
9,184(6) 

56,986 
7,306,951 
3,511,309 

185,875 

- 

203,256 

- 

- 

- 

9 

 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Stuart Ungar, M.D 
David Byrne 
Donald Williams 
Robert Ward 
Mark S. Cohen (3) 
Allan Shaw 

15,956 
- 
- 
- 
42,312 
39,463 

- 
- 
- 
- 
- 
- 

- 
- 
- 
- 
- 
- 

- 
- 
- 
- 
- 
- 

184,548 
- 
- 
- 
188,530 
185,875 

- 
- 
- 
- 
- 
- 

200,504 
- 
- 
- 
230,842(3) 
225,338 

(1) These amounts represent the aggregate grant date fair value for option awards for fiscal year 2015 computed in accordance with FASB ASC Topic 
718.  A discussion of  the assumptions used in determining  grant date fair  value may  be  found in  Akari’s  Financial  Statements,  included  in Akari’s 
Annual Report on Form 20-F for the year ended 31 December 2015. 

(2) Dr. Prudo is party to a non-executive contract although he performs executive duties on behalf of Akari. 

(3) Does not include payments of an aggregate of $451,361 for intellectual property legal services and expenses for third parties in 2015 made to Pearl 
Cohen Zedek Latzer Baratz LLP, of which Mr. Cohen is a senior partner. 

(4) Consists of company contributions to health benefits. 

(5) Consists of company contributions to health benefits of $1,365 and life insurance premiums of $295. 

(6) Consists of company contributions to a pension plan. 

Incentive Plan Awards (subject to audit) 

Akari  operates an  equity  incentive  plan (the  2014  Equity  Incentive Plan  (“2014  Plan”))  under  which  Directors receive 
options to acquire ordinary shares in Akari.  Options awards granted during the fiscal year ended 31 December 2016 are 
as follows:  

Name of Director 

James Hill, M.D 
Stuart Ungar, M.D 
David Byrne 
David Byrne 
Donald Williams 
Donald Williams 
Robert Ward 
Mark S. Cohen 
Mark S. Cohen 

Option 
Awards(1) 
1,300,000 
1,300,000 
1,300,000 
1,300,000 
1,300,000 
1,300,000 
1,300,000 
1,300,000 
1,300,000 

Grant Date  Exercise 

Stock Awards ($) (2) 

29/6/2016 
29/6/2016 
22/4/2016 
29/6/2016 
29/6/2016 
29/6/2016 
13/10/2016 
29/6/2016 
13/10/2016 

Price 

$0.1454 
$0.1454 
$0.1796 
$0.1454 
$0.1454 
$0.1454 
$0.080621 
$0.1454 
$0.080621 

126,226 
126,226 
152,410 
126,226 
126,226 
122,673 
69,062 
126,226 
69,062 

(1) Option awards are subject to time-based vesting. 

(2) These amounts represent the aggregate grant date fair value for option awards for fiscal year 2016 computed in accordance with FASB ASC Topic 
718.  A discussion of  the assumptions used in determining  grant date fair  value may  be  found in  Akari’s  Financial  Statements,  included  in Akari’s 
Annual Report on Form 20-F for the year ended 31 December 2016. 

Payments for Loss of Office 

Mark  Cohen resigned from Akari on 13 October 2016.   Akari has agreed to make payments for loss of  office to Mark 
Cohen  for  an  amount  equal  to  his  director  fees  up  the  date  of  the  annual  general  meeting  in  2018  (June  2018).    The 
amount payable for the payment for loss of office in 2016 is $13,095. 

Director’s shareholdings (subject to audit) 

The table below shows, for each Director, the total number of shares owned, the total number of share options held and 
the  number  of  share  options  vested  as  at  31  December 2016.  No  Director  exercised  any  share  options during  the  year 
ended 31 December 2016. 

Name of Director 
Executive Director 
Ray Prudo 
Gur Roshwalb, M.D 
Clive Richardson 
Non-employee Director 

Ordinary Shares Owned 

Share Options 

Vested Share Options (1) 

722,345,600 (2) 
175,438 
- 

- 
33,323,700 
16,271,850 

- 
10,949,906 
5,084,953 

10 

 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

James Hill, M.D 
Stuart Ungar, M.D 
David Byrne 
Donald Williams 
Robert Ward  
Allan Shaw (3) 
Mark Cohen (4) 

- 
- 
- 
- 
- 
33,530 
2,647,857 

2,600,000 
2,600,000 
2,600,000 
2,600,000 
1,300,000 
- 
4,401,500 

587,518 
574,185 
- 
- 
- 
- 
4,401,500 

(1)  All  share  options  that  were  outstanding  as  at  31  December  2016  use  time-based  vesting  and  are  not  subject  to  performance  targets  other  than 
continued service until the date of vesting. None of the options have been exercised. 

(2) Represents the entire holdings of RPC Pharma Limited. Dr. Prudo has voting and dispositive control over the Ordinary Shares held by RPC Pharma 
Limited and owns approximately 71% of RPC’s outstanding shares (including option grants), including 10.64% of RPC’s outstanding shares held in 
trust for Dr. Ungar. Dr. Prudo disclaims beneficial ownership except to the extent of his actual pecuniary interest in such shares. 

(3) Mr. Shaw’s term as a Class A director expired on 29 June 2016.  

(4) Mr. Cohen resigned as a Class C director on 13 October 2016. 

The remainder of this Directors’ Remuneration Report is not subject to audit. 

Illustration of Total Shareholder Return 

The following graph compares the cumulative total shareholder return on Akari’s ADSs, each representing 100 ordinary 
shares,  with that  of the Nasdaq Biotech  Index from the period that Akari’s shares  were publicly traded on  The Nasdaq 
Capital Market through 31 December 2016. Akari selected the Nasdaq Biotech Index because Akari’s ADSs trade on The 
NASDAQ Capital Market and Akari believes this indicates its relative performance against a  group consisting  of more 
similarly situated companies. 

11 

 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Chief Executive Total Remuneration History 

The table below sets out total remuneration details for the Chief Executive Officer. 

Period 

Single total 
figure of 
remuneration 
$ 

2016 (Gur Roshwalb) 
2015 (Gur Roshwalb) 
2014 (Gur Roshwalb) 
2013 (Gur Roshwalb) (1) 
2012 (2) 

581,250 
7,306,951 
410,564 
576,389 
- 

Annual 
Bonus 

187,500 
86,625 
- 
- 
- 

Short-term 
incentive 
payout  
against 
maximum 
125% (4) 
100% (5) 
- 
- 
- 

Option 
Awards ($) 

- 
6,863,034 
60,564 
173,396 
- 

Option 
Awards  
against 
maximum 
(3) 
- 
- 
- 
- 
- 

(1)  Dr. Roshwalb was appointed as Akari’s Chief Executive Officer on 4 March  2013. 
(2)  Akari was not a quoted company in 2012. 
(3)  All options were awarded on a discretionary basis on an annual basis. 
(4)  Bonus was awarded in 2016 but calculated for a 15 month period from the date of the acquisition of Volution Immuno Pharmaceutical SA on 18 

September 2015.  

(5)  Bonus was awarded in 2015 but calculated for a 9 month period until the date of the acquisition of Volution Immuno Pharmaceutical SA on 18 

September 2015.  

Chief Executive Officer’s Remuneration Compared to Other Employees 

The table below shows the percentage change in remuneration of the Chief Executive Officer and Akari’s employees as a 
whole between the year ended 31 December 2015 and the year ended 31 December 2016. 

Basic Salary 
Annual bonus 
Taxable benefits 

Percentage increase in remuneration 
in year ended 31 December 2016 
compared 
with remuneration in the year ended 
31 December 2015 

CEO 
5% 
116% 
9% 

All employees (1) 
88% 
270% 
6% 

(1) 

Increase was due to the acquisition of Volution Immuno Pharmaceutical SA on 18 September  2015 and subsequent increase in headcount and 
governance changes in Akari as a result of the acquisition. 

Relative Importance of Spend on Pay 

The following table sets forth the total amounts spent by the Company on remuneration for the year ended 31 December 
2016 and the year ended 31 December 2015. Given that Akari remains in the early phases of its business life cycle, the 
comparator chosen to reflect the relative importance of Akari’s spend on pay is Akari’s research and development costs 
as shown in its Annual Report on Form 20-F for the  year ended 31 December 2016.   The Company acquired Volution 
Immuno Pharmaceuticals SA on 18 September 2015 and as a result spending has increased. 

Period 

Total spend on remuneration 
Shareholder distributions 
Research and development costs 

December 

Year Ended  
31 
2016 
$ 
3,145,055 
- 
17,306,001 

December 

Year Ended  
31 
2015 
$ (1) 
1,335,837 
- 
5,799,076 

(1) 

Increase was due to the acquisition of Volution Immuno Pharmaceutical SA on 18 September 2015 and subsequent increase in headcount and 
governance changes in Akari as a result of the acquisition. 

12 

 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Implementation of remuneration policy for year ending 31 December 2017 

The following table presents the salary increases agreed for the upcoming fiscal year   

Director  

Executive Director 
Ray Prudo  
Gur Roshwalb, M.D 
Clive Richardson 
Non-employee Director 
James Hill, M.D 
Stuart Ungar, M.D 
David Byrne 
Donald Williams 
Robert Ward 

31 
December 
2016 

31 
December 
2017 (1) 

Increase 
%  

$200,000 
$375,000 
£210,000 

$206,000 
$450,000 
£252,000 

3% (2) 
20% (3) 
20% (4) 

$56,000 
$50,770 
$21,683 
$25,500 
$10,880 

$57,680 
$47,380 
$47,380 
$52,530 
$47,380 

3% (2) 
3% (2) 
3% (2) 
3% (2) 
3% (2) 

(1) Additional discretionary bonuses may be awarded in accordance with contractual entitlement and the remuneration policy. 

(2) Represents an increase in line with inflation. 

(3)  Represents  an  increase  in  line  with  market  and  industry  compensation  packages  (following  compensation  committees’  consultation  with 
compensation consultants). 

(4) Represents an increase in line with increased global role and to bring Mr. Richardson in line with the US salary ranges. 

Compensation Committee Approach to Remuneration Matters 

The Compensation Committee is comprised of Dr. James Hill (Chairman), Dr. Stuart Ungar, and Mr. David Byrne. All 
members have continued to serve until the date of this Directors’ Remuneration Report.  The charter of the Committee is 
set forth on Akari’s website at http://www.akaritx.com. 

Advice Provided to the Compensation Committee 

The  Committee  retained  Willis  Towers  Watson  to  provide  independent  advice  and  consultation  with  respect  to 
remuneration  arrangements  for  the  Executive  Officers,  senior  management  and  the  Non-Executive  Directors.    Willis 
Towers Watson is a global remuneration consultant with a well established reputation for design and implementation of 
remuneration programmes, including the design and implementation of equity-based award programmes.  The amounts 
paid to Willis Towers Watson in the year ended 31 December 2016 total $39,167. 

In  addition  to  Willis  Towers  Watson,  the  Committee  solicited  and  received  input  from  the  Chief  Executive  Officer 
concerning  the  remuneration  of  senior  executives  other  than  himself.    The  Chief  Executive  Officer  provided 
recommendations  with  respect  to  annual  cash  bonuses  to  be  paid  to  these  persons  for  service  in  the  year  ending  31 
December  2016  and base  salary  awards  effective  from  1  January  2017,  and  with  respect  to  equity-based  awards  to  be 
made to these persons in December 2016.  The Chief Executive Officer also provided input concerning the remuneration 
packages of senior executives appointed during the year.  Finally, the Chief Executive Officer also provided input to the 
Committee  regarding  the  implementation  of  equity-based  remuneration  as  an  element  of  all  other  employees’ 
remuneration. 

Statement of Voting at AGM 

Akari  is  committed  to  ongoing  shareholder  dialogue  and  the  Compensation  Committee  takes  an  active  interest  in 
shareholder views and voting outcomes. 

This is the first year that the Directors’ Remuneration Report is being put to shareholder vote. 

13 

 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

PART II - DIRECTORS’ REMUNERATION POLICY  

INFORMATION PROVIDED IN THIS SECTION OF THE DIRECTORS’ REMUNERATION REPORT IS 
NOT SUBJECT TO AUDIT.  

This Directors’ Remuneration Policy (“Policy”) of Akari Therapeutics, Plc (“Akari”) is subject to shareholder approval at 
the 2017 Annual General Meeting of Shareholders (“AGM”). The Policy provides a framework for execution of Akari’s 
compensation framework from the date of its approval at the 2017 AGM and for a period of three years thereafter, unless 
changes to the Policy are required earlier and a new Policy is put to shareholder vote. 

For the avoidance  of doubt, in approving the  Directors’ remuneration policy, authority is given to  Akari to honour any 
commitments entered into with current or former Directors (such as the payment of a pension, fees or the vesting/exercise 
of past share option awards).  

Akari’s remuneration policy seeks to provide compensation packages which will attract, motivate, reward and retain an 
executive  team  with  the  right  calibre  of  talent,  experience,  and  skills  to  lead  a  successful  future  for  Akari.    Akari’s 
compensation  framework  is  designed  to  provide  a  competitive  package  in  comparison  to  companies  of  similar  size, 
complexity, maturity profile and geographic presence.  

The  table  below  sets  out  the  main  elements  of  Akari’s  remuneration  policy  for  its  Executive  Directors  and  seeks  to 
explain how each element of the compensation package operates: 

Policy table – Executive Directors  

Element 

Base salary 

Purpose and 
link to 
strategy 

Support the 
recruitment 
and retention 
of Executive 
Officers  

Pension 

Other 
Benefits 

Encourages 
and enables 
executives to 
build savings 
for their 
retirement 

Provide 
market 
competitive 
benefits in a 
cost-effective 
way 

Operation 

Maximum opportunity 

Performance 
metrics 

 Base salary levels are 
set taking into account 
the role, responsibilities 
and individual’s 
experience in the 
position, performance of 
the individual and 
Akari. 

 Base salaries are 

typically reviewed 
annually.  

 Akari typically makes 

contributions to pension 
plans (or retirement 
savings plans) to match 
prevailing local market 
practices. 

 None, although 

overall 
performance of the 
individual is 
considered when 
setting and 
reviewing salaries. 

 There is no prescribed 
maximum increase nor 
any requirement to 
increase salary at any 
time. 

 By exception, higher 

increases may be made 
to reflect individual 
circumstances. These 
may include significant 
changes in the job size 
or complexity and/or 
promotion. 

 Currently up to 10% of 

 None. 

salary per annum. 

 Provisions include 

 No prescribed 

 None. 

maximum.  The cost of 
benefits will vary from 
year to year in 
accordance with the cost 
of insuring such 
benefits. 

medical insurance, life 
assurance, permanent 
health insurance, etc. 

 In exceptional 

circumstances, such as 
the relocation of an 
executive or for a new 
hire, additional benefits 

14 

 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Bonus 

To reward the 
delivery of  
annual targets 
as well as to 
recognise the 
individual 
contributions 
towards our 
key strategic 
achievements 

may be provided in the 
form of relocation 
allowance and benefits. 

 Other benefits may be 
offered if considered 
appropriate and 
reasonable by the 
Compensation 
Committee. 

 Any bonus is paid in 

cash typically within 60 
days after the end of the 
financial year to which 
it relates. 

 Performance objectives 
and targets are either 
fixed contractually or 
set annually and actual 
payout levels are 
determined after the 
year end, based on 
performance against 
targets subject to 
overriding discretion of 
the Compensation 
Committee. 

 The maximum annual 
bonus payable for any 
financial year is capped 
at 100% of salary, 
although the 
Compensation 
Committee reserves the 
right to vary this amount 
in exceptional 
circumstances. 

 Where 

performance 
conditions are 
attached to a bonus 
payment, targets 
are either fixed 
contractually or 
selected by the 
Compensation 
Committee and set 
annually and can 
include key 
financial, 
operational and/or 
individual 
objectives. All 
assessments of 
performance 
against target is 
made by the 
Compensation 
Committee in its 
sole discretion. 

Equity 
incentive 
plan 

(2014 Equity 
Incentive 
Plan) 

To motivate 
and reward 
long-term 
performance 
in alignment 
with the 
shareholder 
interests and 
value-creation 

CSOP 

(UK resident 
employees 
and directors 
only) 

 Awards may be made 

periodically to 
Executive Officers in 
the form of options or in 
shares including stock 
appreciation rights, 
phantom stock awards 
or stock units. 

 Awards typically vest 

over three or four years 
and may be subject to 
phased vesting. 

 Executives are eligible 
to participate in the all-
employee CSOP Plan 
under the same 
conditions as all other 
employees.  

 There is no specific 

 Where performance 

maximum set for annual 
equity awards.  

 When making awards, 

the Compensation 
Committee will take 
into account internal 
grant guidelines, which 
have been set in 
reference to local 
market norms.  

conditions are 
attached to an 
award, these 
typically include 
key financial, 
operational and/or 
individual 
objectives subject 
to overall 
Compensation 
Committee 
discretion. 

 Grant value of £30,000 
or local market rules as 
amended from time to 
time. 

 None. 

15 

 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Policy table – Non-Executive Directors 

Akari’s  non-employee  compensation  policy  is  administered  by  its  board  of  directors  with  the  assistance  of  the 
Compensation  Committee.  The  Compensation  Committee  periodically  reviews  non-employee  director  compensation 
policy and makes recommendations to the board.  

Non-Executive Directors typically receive an annual retainer paid in cash for their service (depending on their additional 
membership and chairman responsibilities) and an annual grant of stock options but do not participate in the bonus plan 
to which Executive Officers are eligible, nor do they typically receive any other performance related payment.   

The table below sets out some of the features of Akari’s current non-employee director compensation policy: 

Element 

Annual Cash 
Retainer Fee 

Purpose and 
link to 
strategy 

Support the 
recruitment 
and retention 
of Non-
Executive 
Directors  

Share 
options 

Strengthens 
the alignment 
to 
shareholders’ 
interests 
through share 
ownership  

Operation 

Maximum opportunity 

Performance 
metrics 

 Each Non-Executive 

  There is no 

 None.  

prescribed maximum 
increase nor any 
requirement to 
increase salary at any 
time. 

 None. 

 Normal initial grant and 
annual grant of share 
options will be equal to 
1,300,000 (or equivalent 
value of ADS) but the 
Committee reserves the 
discretion to review and 
amend this amount. 

Director serving on the 
Board receives an 
annual cash retainer, 
with additional amounts 
payable for acting as a 
chairman or a member 
of various committees. 

 In addition, the 

Chairman and Vice 
Chairman receive an 
additional cash retainer. 

 Annual cash retainers 

are typically payable on 
a quarterly basis. 

 A Non-Employee 

Director may elect to 
receive annual cash 
payments in the form of 
fully-vested ordinary 
shares. 

 Directors typically 

receive an annual grant 
of options in the form of 
market value options 
under the 2014 Equity 
Incentive Plan.  

 These awards typically 
vest in full on the date 
of the next AGM 
following the date of 
grant, subject to the 
Non-Executive 
Director’s continued 
service on the Board, 
have a term of 10 years 
from date of grant, and 
vesting accelerates in 
the case of a change of 
control. 

16 

 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

The  foregoing  is  qualified  in  its  entirety  by  Akari’s  current  non-employee  director  compensation  policy,  as  may  be 
amended from time to time.  

Approach to recruitment compensation 

Akari’s policy is to pay a fair remuneration package for the role being undertaken and the experience of the individual to 
be appointed.  

Akari  expects  remuneration  packages  for  Executive  Directors  to  include  base  salary,  targeted  level  of  annual  cash 
incentive,  initial  and  ongoing  equity-based  awards,  standard  benefits  and  special  provisions  tailored  to  the  recruiting 
situation, such as: sign-on bonus, reasonable relocation support and make-whole awards for remuneration forfeited from 
a  prior  employer  (whether  on  account  of  cash  bonuses,  share  awards,  pension  benefits  or  other  forfeited  items).  The 
Compensation  Committee  retains  the  discretion  to  provide  additional  cash,  share  based  payment,  benefits  and  other 
remuneration where necessary or  useful to recruit new Executive Directors or to secure the ongoing service of existing 
Executive Directors.  

The remuneration package for any new non-Executive Director will be set in accordance with the terms of Akari’s non-
employee director compensation policy then in effect.  

Director’s service contracts 

Akari’s board of directors is divided into three classes for purposes of election (Class A Directors, who serve a one year 
term before being subject to re-election at Akari’s annual general meeting; Class B Directors, who serve a two year term 
before  being  subject  to  re-election  at  the  annual  general  meeting;  and  Class  C  Directors  who  serve  a  three  year  term 
before being subject to re-election at the annual general meeting, provided also that in any two year period, a majority of 
the board must stand for re-election).  

Service contracts are available for inspection at Akari’s registered office or 75/76 Wimpole Street London W1G 9RT. 

Policy on Payments for Loss of Office 

Akari’s  approach  to  payments  to  Executive  Directors  in  the  event  of  termination  is  to  take  account  of  the  individual 
circumstances including the reason for termination, individual performance, contractual obligations and the terms of any 
option award. 

Generally, Akari expects that employment arrangements for any Executive  Director will include a notice provision and 
continuing payment obligations as per the individual Executive Director service contracts following termination by Akari 
of an Executive Director  without cause or termination by  the Executive  Director  for good reason  or change of control. 
Payment  obligations  could  include  base  salary,  benefits,  and  all  or  some  portion  of  target  annual  cash  remuneration. 
Akari may offer payment in lieu of notice if it is considered to be in the best interests of Akari. 

Treatment  of  unvested  outstanding  equity  awards  will  be  determined  according  to  the  specific  nature  of  termination, 
individual contracts, and plan rules. 

The  Compensation  Committee  reserves  the  right  to  make  payments  it  considers  reasonable  under  a  compromise  or 
settlement agreement, including payment or reimbursement of reasonable legal and professional fees, and any payment or 
compensation  (in  whatever  form)  in  respect  of  statutory  rights  under  employment  law  in  the  US,  UK  or  other 
jurisdictions. Payment or reimbursement (in whatever forms) of reasonable outplacement fees may also be provided. 

Other relevant information considered 

As appropriate, the Compensation Committee considers the pay and conditions of the broader employee workforce when 
making compensation related decisions for the Directors.  

The Compensation Committee also considers shareholder feedback, so far as it relates to compensation, when reviewing 
of the appropriateness of its Policy. 

This report was approved by the board on 15 May 2017 and signed on its behalf. 

Dr. R Prudo 
Executive Chairman 

17 

 
 
 
 
INDEPENDENT AUDITORS’ REPORT TO THE SHAREHOLDER OF 

AKARI THERAPEUTICS PLC  

We  have  audited  the  financial  statements  of  Akari  Therapeutics  Plc  for  the  year  ended  31  December  2016  which 
comprise the  Consolidated Statement  of Comprehensive  Loss, the Consolidated  and  Company  Statements  of  Financial 
Position, the Consolidated and Company Statement of Changes in Equity, the Consolidated Statement of Cash Flows and 
the  related  notes.  The  financial  reporting  framework  that  has  been  applied  in  their  preparation  is  applicable  law  and 
International  Financial  Reporting  Standards  (IFRSs)  as  adopted  by  the  European  Union  and,  as  regards  the  parent 
company financial statements, as applied in accordance with the provisions of the Companies Act 2006. 

This  report  is  made  solely  to  the  company's  shareholders,  as  a  body,  in  accordance  with  Chapter  3  of  Part  16  of  the 
Companies  Act  2006.  Our  audit  work  has  been  undertaken  so  that  we  might  state  to  the  company's  members  those 
matters we are required to state to them in an Auditor's report and for no other purpose. To the fullest extent permitted by 
law, we do not accept or assume responsibility to anyone other than the company and the company's members as a body, 
for our audit work, for this report, or for the opinions we have formed. 

Respective responsibilities of directors and auditors 
As explained more fully in the Statement of Directors’ Responsibilities, the directors are responsible for the preparation 
of the financial statements and for  being  satisfied that  they give a  true and  fair  view. Our  responsibility  is  to audit  the 
financial statements in accordance with applicable law and International Standards on Auditing (UK and Ireland). Those 
standards require us to comply with the Auditing Practices Board’s Ethical Standards for Auditors. 

Scope of the audit of the financial statements 
A description of the scope of an audit of financial statements is provided on the Financial Reporting Council's website at 
www.frc.org.uk/auditscopeukprivate. 

Opinion on financial statements 
In our opinion: 

 

 

 

 

the financial statements give a true and fair view of the state of the group’s and of the parent company’s affairs 
as at 31 December 2016 and of the group’s loss for the year then ended; 
the  group  financial  statements  have  been  properly  prepared  in  accordance  with  IFRSs  as  adopted  by  the 
European Union;  
the parent company financial statements have been properly  prepared in accordance with IFRSs as adopted by 
the European Union and as applied in accordance with the provisions of the Companies Act 2006; and 
the  financial  statements  have  been  prepared  in  accordance  with  the  requirements  of  the  Companies  Act  2006 
and, as regards the group financial statements, Article 4 of the IAS Regulation. 

Opinion on other matter prescribed by the Companies Act 2006 
In  our  opinion the information given in the  Directors’ Report and Strategic Report for the financial  year for which  the 
financial  statements  are  prepared  is  consistent  with  the  financial  statements  and  these  reports  have  been  prepared  in 
accordance with applicable legal requirements. 

In the light of our knowledge and understanding of the Group and its environment obtained in the course of the audit, we 
have not identified material misstatements in the Directors' Report and Strategic Report. 

The  part  of  the  Directors’  Remuneration  Report  to  be  audited  has  been  properly  prepared  in  accordance  with  the 
Companies Act 2006. 

Matters on which we are required to report by exception 
We have nothing to report in respect of the following matters where the Companies Act 2006 requires us to report to you 
if, in our opinion: 

 

 

adequate accounting records have not been kept by the parent company, or returns adequate for our audit have 
not been received from branches not visited by us; or 
the parent company financial statements and the part of Directors’ Remuneration Report to be audited are not in 
agreement with the accounting records and returns; or 
 
certain disclosures of directors’ remuneration specified by law are not made; or 
  we have not received all the information and explanations we require for our audit. 

Ian Cliffe (Senior statutory auditor)   
for and on behalf of haysmacintyre, Statutory Auditor 
15 May 2017 

26 Red Lion Square 
London WC1R 4AG 

18 

 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC 

CONSOLIDATED INCOME STATEMENT OF COMPREHENSIVE LOSS 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Research and development expenses 
Administrative expenses 
Goodwill impairment 

OPERATING LOSS 

Net finance income 

LOSS BEFORE INCOME TAX 

Income Tax Expense 

LOSS FOR THE YEAR 

Other Comprehensive (Loss) Income: 
Currency translation differences  

COMPREHENSIVE LOSS FOR THE YEAR 

Notes 

3 

4 

2016 
$000 

(17,306) 
(9,941) 
- 
--------------- 
(27,247) 

1,023 
--------------- 
(26,224) 

- 
--------------- 
(26,224) 
======= 

(437) 
--------------- 
(26,661) 
======= 

2015 
$000 

(5,799) 
(5,502) 
(19,284) 
--------------- 
(30,585) 

978 
--------------- 
(29,607) 

- 
--------------- 
(29,607) 
======= 

111 
--------------- 
(29,496) 
======= 

All losses are derived from continuing activities for the current and previous financial year. 

The Company has elected to take the exemption under section 408 of the Companies Act 2006 not to present the parent 
company income statement. Refer note 5 for the results of the parent company.  

The notes on pages 25 to 37 form an integral part of the consolidated financial statements. 

19 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

COMPANY NUMBER: 05252842 

CONSOLIDATED STATEMENT OF FINANCIAL POSITION 

AS AT 31 DECEMBER 2016 

ASSETS 
Non-current assets 
Property, plant and equipment 
Intangible Assets 

Current assets 
Trade and Other receivables 
Cash and cash equivalents  
Short term investments 

TOTAL ASSETS 

EQUITY 
Capital and reserves attributable to the Company’s 
 equity shareholders 
Called up share capital 
Share premium 
Other reserves 
Merger reserve 
Share based payment reserve 
Reverse Acquisition reserve 
Retained earnings  

TOTAL EQUITY  

LIABILITIES 
Non Current Liabilities 
Warrants 
Other long term liabilities 
Current liabilities 
Trade and other payables 

TOTAL LIABILITIES 

TOTAL EQUITY AND LIABILITIES 

Notes 

2016 
$000 

2015 
$000 

7 
6 

9 

12 
13 
13 
13 
13 
13 
13 

11 
11 

10 

58 
39 
--------------- 
97 

1,513 
34,241 
10,022 
--------------- 
45,776 
--------------- 
45,873 
======= 

18,341 
94,778 
(280) 
9,128 
8,029 
(20,983) 
(67,283) 
--------------- 
41,730 
--------------- 

35 
56 

4,052 
--------------- 
4,143 
--------------- 
45,873 
======= 

41 
52 
--------------- 
93 

739 
69,062 
- 
--------------- 
69,801 
--------------- 
69,894 
======= 

18,341 
94,778 
157 
9,128 
4,096 
(20,983) 
(41,086) 
--------------- 
64,431 
--------------- 

685 
49 

4,729 
--------------- 
5,463 
--------------- 
69,894 
======= 

The financial statements were approved and authorised for issue by the Board of Directors on 15 May 2017 
and were signed below on its behalf by:                      

Dr. R Prudo 
Executive Chairman 

The notes on pages 25 to 37 form an integral part of these consolidated financial statements. 

20 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

  COMPANY NUMBER: 05252842 

PARENT COMPANY STATEMENT OF FINANCIAL POSITION 

AS AT 31 DECEMBER 2016 

ASSETS 
Non-current assets 
Property, plant and equipment 
Investment in subsidiaries 

Current assets 
Trade and Other receivables 
Cash and cash equivalents  
Short term investments 

TOTAL ASSETS 

EQUITY 
Capital and reserves attributable to the Company’s 
 equity shareholders 
Called up share capital 
Share premium 
Merger reserve 
Share based payment reserve 
Retained earnings  

TOTAL EQUITY  

LIABILITIES 
Non Current Liabilities 
Warrants 
Other long term liabilities 
Current liabilities 
Trade and other payables 

TOTAL LIABILITIES 

TOTAL EQUITY AND LIABILITIES 

Notes 

2016 
$000 

2015 
$000 

7 
8 

9 

12 
13 
13 
13 
13 

11 
11 

10 

58 
20,339 
--------------- 
20,397 

5,589 
34,115 
10,022 
--------------- 
49,726 
--------------- 
70,123 
======= 

18,341 
94,778 
9,128 
8,029 
(64,231) 
--------------- 
66,045 
--------------- 

35 
56 

3,987 
--------------- 
4,078 
--------------- 
70,123 
======= 

41 
20,339 
--------------- 
20,380 

4,337 
68,685 
- 
--------------- 
73,022 
--------------- 
93,402 
=======  

18,341 
94,778 
9,128 
4,096 
(38,221) 
--------------- 
88,122 
--------------- 

685 
49 

4,546 
--------------- 
5,280 
--------------- 
93,402 
======= 

The financial statements were approved and authorised for issue by the Board of Directors on 15 May 2017 
and were signed below on its behalf by:                      

Dr. R Prudo 
Executive Chairman 

The notes on pages 25 to 37 form an integral part of these consolidated financial statements. 

21 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Share 
Capital 
$000 

Share 

Other   Merger 
Premium  Reserves  Reserve 
$000 

$000 

$000 

Share 
Based 
Payment 
Reserve 
$000 

Reverse 
Acquis- 
ition 
Reserve 
$000 

Retained  
Loss 
$000 

Total 
$000 

(11,479) 

2,224

At I January 2015 

11,211 

2,446 

Comprehensive loss for the year 
Shares in issue by parent prior to 
reverse acquisition 
Reverse acquisition adjustment 
Issue  of 
acquisition 
Issue of shares 
Issue of shares for advisory fees  
Share based payments 

shares  on 

reverse 

At 31 December 2015 

Comprehensive loss for the year 
Share based payments 
Dissolution of subsidiary 

At 31 December 2016 

- 
927 

(11,211) 
11,211 

6,144 
59 
- 
-------------- 
18,341 
======= 

- 
- 
- 
-------------- 
18,341 
======= 

- 
30,657 

(2,446) 
- 

63,430 
691 
- 
-------------- 
94,778 
======= 

- 
- 
- 
-------------- 
94,778 
======= 

46 

111 
- 

- 
- 

- 
- 
- 
-------------- 
157 
======= 

(437)
- 
- 
-------------- 
(280)
======= 

- 

- 
- 

-

-
3,056

- 

- 
- 

(29,607) 
- 

- 
9,128 

- 
- 
- 
-------------- 
9,128 
======= 

- 
- 
- 
-------------- 
9,128 
======= 

-
-

(20,983) 
- 

- 
- 

-
-
1,040
--------------
4,096
=======

-
3,933
-
--------------
8,029
=======

- 
- 
- 
-------------- 
(20,983) 
======= 

- 
- 
- 
-------------- 
(20,983) 
======= 

- 
- 
- 
-------------- 
(41,086) 
======= 

(26,224) 
- 
27 
-------------- 
(67,283) 
======= 

(29,496)
34,640

(34,640)
20,339

69,574
750
1,040
--------------
64,431
=======

(26,661)
3,933
27
--------------
41,730
=======

PARENT COMPANY STATEMENT OF CHANGES IN EQUITY 

Share 
Capital 
$000 

Share 
Premium 
$000 

Merger  
Reserve 
$000 

Share Based 
Payment 
Reserve 
$000 

At I January 2015 

927 

30,657 

Total comprehensive loss for the year 
Share based payments 
Issue of shares on reverse acquisition 
Issue of shares (relating to financing, net of 
issue costs) 
Issue  of  shares  for  advisory  fees  (net  of 
costs) 

At 31 December 2015 

Total comprehensive loss for the year 
Share based payments 
Dissolution of subsidiary 

At 31 December 2016 

- 
- 
11,211 

- 
- 
- 

6,144 

63,430 

59 
-------------- 
18,341 
======= 

- 
- 
- 
-------------- 
18,341 
======= 

691 
-------------- 
94,778 
======= 

- 
- 
- 
-------------- 
94,778 
======= 

- 

- 
- 
9,128 

- 

- 
-------------- 
9,128 
======= 

- 
- 
- 
-------------- 
9,128 
======= 

2,964 

- 
1,132 
- 

- 

- 
-------------- 
4,096 
======= 

- 
3,933 
- 
-------------- 
8,029 
======= 

The notes on pages 25 to 37 form an integral part of these consolidated financial statements. 

Retained 
Loss 
$000 

Total 
$000 

(29,306) 

5,242 

(8,915) 
- 
- 

(8,915) 
1,132 
20,339 

- 

69,574 

- 
-------------- 
(38,221) 
======= 

(26,037) 
- 
27 
-------------- 
(64,231) 
======= 

750 
-------------- 
88,122 
======= 

(26,037) 
3,933 
27 
-------------- 
66,045 
======= 

22 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

CONSOLIDATED STATEMENT OF CASH FLOWS 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Cash flows from operating activities 
 Loss before income tax 
Adjustments for: 
Changes in fair value of warrants 
Share-based payment 
Compensation expense 
Goodwill impairment 
Foreign currency exchange gains 
Depreciation and amortisation 
Trade and other receivables 
Trade and other payables 
Other liabilities 

Net cash flows used in operating activities  

Cash flow from investing activities 
Cash received from reverse acquisition 
Receivable from related party 
Purchase of property and equipment 
Purchase of short-term investments 
Maturities of short-term investments 

Net cash used (from) investing activities 

Cash flows from financing activities 
Proceeds from shareholder loans 
Payments of shareholder loans 
Proceeds from issuance of Ordinary shares 
Issue costs 

Cash generated from financing activities 

Exchange (losses) gains on cash and cash equivalents 

Net increase in cash and cash equivalents 
Cash and cash equivalents at beginning of period 

Cash and cash equivalents at end of period 

2016 
$000 

2015 
$000 

(26,224) 

(29,607) 

(650) 
3,933 
- 
- 
(273) 
51 
(786) 
(672) 
7 
------------ 
(24,614) 

- 
10 
(55) 
(46,120) 
36,098 
------------ 
(10,067) 

- 
- 
- 
- 
------------ 
- 

(140) 

(34,821) 
69,062 
------------ 
34,241 
======== 

(1,115) 
1,040 
750 
19,283 
- 
10 
914 
3,755 
3 
------------ 
(4,967) 

1,552 
(8) 
(11) 
- 
- 
------------ 
1,533 

3,031 
(3,561) 
75,000 
(5,426) 
------------ 
69,044 

125 

65,735 
3,327 
------------ 
69,062 
======== 

The notes on pages 25 to 37 form an integral part of these consolidated financial statements. 

23 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

PARENT COMPANY STATEMENT OF CASH FLOWS 

FOR THE YEAR ENDED 31 DECEMBER 2016 

Cash flows from operating activities 
Loss before income tax 
Adjustments for: 
Changes in fair value of warrants 
Share based payments 
Compensation expense 
Depreciation 
Trade and other receivables 
Trade and other payables 
Taxation 
Exchange rate differences 
Other liabilities 

Net cash flows used in operating activities  

Cash flow from investing activities 
Purchase of property, plant and equipment 
Purchase of short-term investments 
Maturities of short-term investments 

Net cash used in investing activities 

Cash flows from financing activities 
Proceeds from issuance of Ordinary shares 
Issue costs 

Cash generated from financing activities 

2016 
$000 

2015 
$000 

(26,037) 

(10,646) 

(650) 
3,933 
- 
38 
(1,252) 
(559) 
- 
- 
7 
------------ 
(24,520) 

(55) 
(46,120) 
36,098 
------------ 
(10,077) 

- 
- 
------------ 
- 

451 
1,132 
750 
19 
(3,700) 
3,203 
1,563 
(8) 
- 
------------ 
(7,236) 

(11) 
- 
- 
------------ 
(11) 

75,000 
(5,426) 
------------ 
69,574 

Exchange gains on cash and cash equivalents 

27 

- 

Net increase in cash and cash equivalents 
Cash and cash equivalents at beginning of period 

Cash and cash equivalents at end of period 

(34,570) 
68,685 
------------ 
34,115 
======== 

62,327 
6,358 
------------ 
68,685 
======== 

The notes on pages 25 to 37 form an integral part of these consolidated financial statements. 

24 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2016 

1.  

ACCOUNTING POLICIES 

 The principal accounting policies applied in the preparation of these consolidated financial statements are set out 
below. These policies have been consistently applied to all the years presented, unless otherwise stated. 

(a) 

Basis of preparation 
These  consolidated  financial  statements  of  Akari  Therapeutics  Plc  have  been  prepared  in  accordance  with 
International Financial Reporting Standards (IFRS) and IFRIC interpretations issued and effective or issued and 
early  adopted  as  at  the  time  of  preparing  these  statements  and  with  those  parts  of  the  Companies  Act  2006 
applicable to companies reporting under IFRS. The consolidated financial statements are prepared on a historical 
cost conversion. A summary of the more important accounting policies is set out below.   

The  preparation  of  financial  statements  in  conformity  with  IFRS  requires  the  use  of  certain  critical  accounting 
estimates. It also requires management to exercise its judgement in the process of applying the Group’s accounting 
policies.  The  areas  involving  a  higher  degree  of  judgement  or  complexity  or  areas  where  assumptions  and 
estimates are significant to the consolidated financial statements are disclosed in note 1(n). 

(b) 

Basis of consolidation 
Subsidiaries are all entities over which the Group has control. The Group controls an entity when the Group is  
exposed  to,  or  has  rights  to,  variable  returns  from  its  involvement  with  the  entity  and  has  the  ability  to 
affect those returns through its power over the entity. The subsidiaries are fully consolidated from the date   on 
which control is transferred to the Group and deconsolidated from the date that control ceases.  

The  financial  statements  of  the  subsidiaries  are  prepared  for  the  same  financial  year  as  the  parent  company, 
applying  consistent  accounting  policies  throughout  the  Group.  Inter-company  balances  and  transactions, 
including unrealised profits are eliminated on consolidation. 

The Group financial statements consolidate the Company’s financial statements  of Akari Therapeutics Plc and 
its  subsidiaries  (the  “Group”).  The  consolidated  financial  statements  include  the  accounts  of  the  Company, 
Volution and Volution Immuno Pharmaceuticals Ltd (a UK Ltd Company), its wholly-owned subsidiary, which 
was incorporated in London on 22 August 2015.  On 6 September 2016, Volution Immuno Pharmaceuticals Ltd 
was dissolved. 

(c) 

Foreign currency translation 
Functional and presentation currency 
Items included in the financial statements of each of the Group’s entities are measured using the currency of the 
primary economic environment in which the entity operates (the “functional currency”). The functional currency 
of Akari Therapeutics Plc is U.S. dollars.  The Group and Parent Company financial statements are presented in 
U.S Dollars which is considered to the Group’s presentation currency.  

Transactions and balances  
Foreign  currency  transactions are  translated  into  the  functional  currency  using  the  exchange  rate  prevailing  at 
the  date  of  the  transactions  or  valuation  where  items  are  re-measured.  Foreign  exchange  gains  and  losses 
resulting  from  the  settlement  of  such  transactions  and  from  the  translation  at  period-end  exchange  rates  of 
monetary assets and liabilities denominated in foreign currencies are recognised in the income statement. 

Group companies 
The  results  and  financial  position  of  all  the  Group  entities  (none  of  which  has  the  currency  of  a  hyper-
inflationary economy) that have a functional currency different from the presentation currency are translated as 
follows: 

(a) 

(b) 
(c) 

assets and liabilities at the balance sheet date are translated at the closing rate as at that balance sheet 
date; 
income and expenses for each income statement are translated at average exchange rates; and 
all resulting exchange differences are recognised in other comprehensive income. 

25 

 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

1. 

ACCOUNTING POLICIES (continued) 

(d)    

Financial instruments 
Cash and cash equivalents   
Cash and cash equivalents includes cash in hand, deposits held at call with banks, other short-term highly liquid 
investments  with  original  maturities  of three months  or  less,  and  bank  overdrafts.   Bank  overdrafts are  shown 
within borrowings in current liabilities on the balance sheet. 

Trade and other receivables  
Trade  and  other  receivables  are  recognised  at  fair  value  less  a  provision  for  impairment.    Bad  debts  are  written  off 
through the income statement when identified. If collection is expected in one year or less, they are classified as current 
assets. If not, they are presented as non-current assets.    

Trade and other payables 
Trade  payables  are  obligations  to  pay  for  goods  or  services  received  that  have  been  acquired  in  the  ordinary 
course of the business from suppliers. Trade payables are classified as current liabilities if payment is due within 
one  year or less. If not, they are presented  as non-current liabilities.  Executory contracts are recognised when 
both parties to the contract met their respective obligations. Trade and other payable are  unsecured, non-interest 
bearing and are stated at cost. 

The Group's liability related to options and warrants related to equity and debt financing and are recognised on 
the  balance  sheet  at  their  fair  value,  with  changes  in  the  fair  value  accounted  for  in  the  statement  of 
comprehensive loss and included in financing income or expenses. 

Share capital 
Ordinary shares are classified as equity.  Incremental costs directly attributable to the issue of shares or options 
are shown in equity as a deduction, net of tax, from the proceeds.  

(e)  

Research and development expenditure 
Research  costs  are  expensed  through  the  income  statement  as  they  are  incurred.  Research  and  development 
expenses  include,  among  other  costs,  costs  incurred  by  outside  laboratories  and  other  accredited  facilities  in 
connection with clinical trials and preclinical studies.  

Under IAS 38, development costs are only capitalised after technical and commercial feasibility of the asset for 
sale or use have been established. The company must intend and be able to complete the asset and either use it 
or sell it and be able to demonstrate how the asset will generate future economic benefit. If the company cannot 
distinguish between the research and the development phase, then all costs are expensed as research costs. 

(f)  

Property, plant and equipment: 
Property,  plant  and  equipment  are  measured  at  cost,  including  directly  attributable  costs,  less  accumulated 
depreciation  and  excluding  day-to-day  servicing  expenses.    The  assets  residual  values  and  useful  lives  are 
reviewed, and adjusted if appropriate, at the end of each reporting period. 

Depreciation is calculated on a straight-line basis over the useful life of the assets at annual rates as follows: 

Computers, peripheral and scientific equipment - 33%  
Office furniture and equipment 

- 33% 

The Group reviews all long-lived assets for impairment whenever events or circumstances indicate the carrying 
amount  of  such  assets  may  not  be  recoverable.  Recoverability  of  assets  to  be  held  or  used  is  measured  by 
comparison of the carrying value of the asset to the future undiscounted net cash flows expected to be generated 
by the asset. If such asset is considered to be impaired, the impairment recognised is measured by the amount by 
which the carrying value of the asset exceeds the discounted future cash flows expected to be generated by the 
asset. 

26 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

1. 

ACCOUNTING POLICIES (continued) 

(g) 

   Intangible assets:  

(h) 

(i) 

Patent acquisition costs and related capitalised legal fees are recognised at historical cost. Patents have a finite 
useful life and are carried at cost less accumulated amortisation.  Amortisation is calculated using the straight-
line  basis  method  and  are  amortised  over  the  shorter  of  the  legal  or  useful  life.  The  estimated  useful  life  for 
current patents is twenty two years. 

The Group expenses costs associated with maintaining and defending patents subsequent to their issuance in the 
period the costs are incurred. 

Investments 
Investments in subsidiary undertakings are stated at cost less provisions for impairment. 

Share-based payments and warrants 
Where  share  options  or  warrants  are  awarded  to  directors  and  employees,  the  fair  value  of  the  options  or 
warrants at the grant date is charged to the consolidated income statement over the vesting period. Non-market 
vesting conditions are taken into account by adjusting the number of equity instruments expected to vest at each 
balance sheet date so that, ultimately, the cumulative amount recognised over the vesting period is based on the 
number of options that eventually vest. Market vesting conditions are factored into the fair value of the options 
and  warrants  granted.  As  long  as  all  other  vesting  conditions  are  satisfied,  a  charge  is  made  irrespective  of 
whether  the  market  vesting  conditions  are  satisfied.  The  cumulative  expense  is  not  adjusted  for  failure  to 
achieve a market vesting condition. 

Where the terms and conditions of options and warrants are modified before they vest, the increase in the fair 
value of the options and warrants,  measured immediately  before and  after the modification, is also charged to 
the consolidated income statement over the remaining vesting period. 

When the options and warrants are exercised, the company issues new shares. The proceeds received net of any 
directly attributable transaction costs are credited to share capital (nominal value) and share premium when the 
options and warrants are exercised. 

When share options and warrants lapse, any amounts credited to the share-based payments reserve are released 
to the retained earnings reserve. 

(k) 

Finance income and expenses 
Interest income and expenses are recognised using the effective interest method.  It mainly  comprise of changes 
in the fair value of financial assets and liabilities that are measured at fair value through the income statement 
and exchange gains and losses which is reported on a net basis in the statement of comprehensive loss.  

(l)        Operating lease agreements 

Leases  in  which  a  significant  portion  of  the  risks  and  rewards  of  ownership  are  retained  by  the  lessor  are 
classified  as  operating  leases.  Payments  made  on  operating  leases  are  charged  to  the  income  statement  on  a 
straight line basis over the period of the lease. 

(m)  Deferred taxation 

Deferred tax is provided in full, using the liability method, on temporary differences arising between the tax bases 
of assets and liabilities and their carrying values in the financial statements.  The deferred tax is not accounted for if 
it arises from initial recognition of an asset or liability in a transaction, other than a business combination, that at 
the time of the transaction does not affect either the accounting or taxable profit or loss.  Deferred tax is determined 
using  tax  rates  (and  laws)  that  have  been  enacted  or  substantially  enacted  by  the  balance  sheet  date  and  are 
expected to apply when the related deferred tax asset is realised or the deferred tax liability is settled. 

Deferred tax assets are recognised to the extent that it is probable that future taxable profit will be available against 
which temporary differences can be utilised. 

27 

 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

1. 

ACCOUNTING POLICIES (continued) 

(n)       Critical accounting estimates and judgements: 

The  Group  makes  estimates  and  assumptions  concerning  the  future.  The  preparation  of  financial  statements 
requires management and the Board of Directors to make estimates and judgments that affect reported amounts 
of  assets,  liabilities,  revenues  and  expenses,  and  related  disclosure  of  contingent  assets  and  liabilities.  These 
estimates  are  based  on  historical  experience  and  various  other  assumptions  that  management  and  the  Board 
believe are reasonable under the circumstances, the results of which form the basis for making judgments about 
the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may 
differ  from  these  estimates  under  different  assumptions  or  conditions,  significantly  impacting  earnings  and 
financial position. 

Management  believes  that  the  following  areas,  all  of  which  are  discussed  and  separately  marked  in  the 
respective  sections  of  Note  1  “Accounting  Policies,”  comprise  the  most  difficult,  subjective  or  complex 
judgments it has to make in the preparation  of the financial statements: valuation  of intangible and other non-
current assets, deferred taxation, and collecting trade receivables. 

(o)       Business combinations: 

Business combinations on  or after 1 January 2004 are accounted for under  IFRS  3 (“Business combinations”) 
using the purchase price method. Any excess of the cost of business combinations over the group’s interest in 
the net fair value of the identifiable assets, liabilities and contingent liabilities is recognised in the balance sheet 
as goodwill.  

After initial recognition, goodwill is not amortised but is  stated at cost  less  any  accumulated  impairment loss, 
with  the  carrying  value  being  reviewed  for  impairment,  at  least  annually  and  whenever  events  or  changes  in 
circumstances indicate that the carrying value may be impaired.  

For the  purpose of  impairment testing,  goodwill is allocated to the related  cash  generating units monitored by 
management.  Where  the  recoverable  amount  of  the  cash  generating  unit  is  less  than  its  carrying  amount, 
including goodwill, an impairment loss is recognised in the income statement.  

Intangible assets are tested annually for impairment and other non-current assets are tested where an indication 
of  impairment  arises.  The  assessment  of  impairment  is  made  by  comparing  the  carrying  amount  of  cash 
generating  units  (including  any  associated  goodwill)  to  the  higher  of  their  value  in  use  and  their  fair  value. 
Value in use represents the net present value of future discounted cash flows.  

Any impairment of non-current assets are recognised in the income statement. 

2. 

EXPENSES BY NATURE 

Employee benefit expense (see below) 
Depreciation 
Amortisation 
Exchange loss 
Auditors’ remuneration 
- audit fees 
- other services  

2016 
$000 

2,722 
38 
13 
(273) 

20 
2 
======= 

2015 
$000 

551 
10 
7 
91 

27 
5 
====== 

28 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

2. 

EXPENSES BY NATURE (continued) 

Employee benefit expense 
Wages and salaries 
Social security costs 

The average number of persons (including directors) 
 employed by the group during the year was as follows: 
  Office and administration 

Key management remuneration 
Wages and salaries 

2016 
$000 

2,453 
269 
-------------- 
2,722 
======= 

20 
======= 

1,928 
======= 

2015 
$000 

520 
31 
-------------- 
551 
======= 

9 

======= 

310 
======= 

The  Key  management  is  considered  to  be  the  directors  and  senior  management  team.    Details  of  directors’ 
remuneration can be seen within the Directors’ Remuneration Report on pages 9 to 17. 

3. 

NET FINANCE INCOME 

Change in value of liability related to warrants 
Net foreign exchange gains (losses) 
Interest Income 
Interest Expense 
Other taxes 

4(a). 

INCOME TAX EXPENSE 

Current tax: 
Current tax on losses for the year 
Adjustment in respect of prior years 

The tax assessed in the year is different from the standard rate of  
corporation tax in the UK of 20.00% in 2016 and 20.25% in 2015.   
The differences are explained below:  

Loss before tax  

Loss on ordinary activities before tax multiplied by the standard  
companies’ rate of tax in the UK 

Effects of: 
Losses carried forward 

Tax charge 

29 

2016 
$000 

650 
273 
143 
(39) 
(5) 
--------------- 
1,022 
======= 

2016 
$000 

- 
- 
------------- 
- 
====== 

2015 
$000 

1,115 
(91) 
21 
(23) 
(44) 
--------------- 
978 
======= 

2015 
$000 

- 
- 
------------- 
- 
======= 

(26,224) 

======= 

(29,607) 
======= 

(5,245) 

(5,995) 

5,245 
-------------- 
- 
======= 

5,995 
-------------- 
- 
======= 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

5. 

LOSS ATTRIBUTABLE TO THE PARENT COMPANY 

The parent Company has taken advantage of section 408 of the Companies Act 2006 and has not included its own 
profit  and  loss  account  in  these  financial  statements.    The  parent  Company  has  made  a  loss  for  the  year  of 
$26,037,000 (2015: $8,915,000). 

6. 

INTANGIBLE ASSETS 
GROUP  

Cost 
At 1 January 2016  
Additions 

At 31 December 2016 

Amortisation 
At 1 January 2016 
Charge for the year 

At 31 December 2016 

Net Book Value 
At 31 December 2016 

At 31 December 2015  

Patent 
acquisition costs 
$000 

95 
- 
--------------- 
95 
--------------- 

(43) 
(13) 
--------------- 
(56) 
--------------- 

39 
======= 
52 
======= 

7. 

PROPERTY PLANT AND EQUIPMENT 
GROUP  

Office furniture 
and equipment 
$000 

Cost 
At 1 January 2016 
Additions 

At 31 December 2016 

Depreciation 
At 1 January 2016 
Charge for the year 

At 31 December 2016 

Net Book Value 
At 31 December 2016 

At 31 December 2015  

80 
55 
--------------- 
135 
--------------- 

(39) 
(38) 
--------------- 
(77) 
--------------- 

58 
======= 
41 
======= 

30 

Total 
$000 

95 
- 
--------------- 
95 
--------------- 

(43) 
(13) 
--------------- 
(56) 
--------------- 

39 
======= 
52 
======= 

Total 
$000 

80 
55 
--------------- 
135 
--------------- 

(39) 
(38) 
--------------- 
(77) 
--------------- 

58 
======= 
41 
======= 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

7. 

PROPERTY PLANT AND EQUIPMENT 
COMPANY 

Office furniture 
and equipment 
$000 

Cost 
At 1 January 2016  
Additions 

At 31 December 2016 

Depreciation 
At 1 January 2016 
Charge for the year 

At 31 December 2016 

Net Book Value 
At 31 December 2016 

At 31 December 2015  

80 
55 
--------------- 
135 
--------------- 

(39) 
(38) 
--------------- 
(77) 
--------------- 

58 
======= 
41 
======= 

Total 
$000 

80 
55 
--------------- 
135 
--------------- 

(39) 
(38) 
--------------- 
(77) 
--------------- 

58 
======= 
41 
======= 

8. 

INVESTMENTS IN SUBSIDIARIES 

Company 

Investments in 
Subsidiary 
Undertakings 

$000 

At 1 January 2016 
Additions 

20,339 
- 
---------- 
At 31 December 2016 
20,339 
                                                                                                                                                                                              ====== 

The Company directly owns 100% of the issued share capital of the following subsidiary undertakings, which 
have been included in the consolidated financial statements: 

Volution Immuno 
Pharmaceuticals SA  
Celsus Therapeutics Inc. 
Morria Biopharma Ltd.  

Principal activity 

Development of 
pharmaceutical drugs 
Dormant 
Dormant 

Country of 
incorporation 

Holdings 

Switzerland 

Ordinary 

United States 
Israel 

Ordinary 
Ordinary 

% 

100 

100 
100 

Volution Immuno Pharmaceuticals Ltd was dissolved on 6 September 2016. 

31 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

9. 

TRADE AND OTHER  
RECEIVABLES 

Trade and other receivables 
Prepayments and accrued income 

2016 
$000 

176 
1,337 
----------- 
1,513 
===== 

Group 

Company 

2015 
$000 

10 
729 
----------- 
739 
===== 

2016 
$000 

4,267
1,322
----------
5,589
=====

2015 
$000 

3,645 
692 
---------- 
4,337 
===== 

10. 

TRADE AND OTHER PAYABLES 

Group 

Company 

Trade payables 
Accrued expenses 

2016 
$000 

2,316 
1,736 
--------------- 
4,052 
======= 

2015 
$000 

2016 
$000 

4,321 
408 
--------------- 
4,729 
======= 

2,275
1,712
-------------
3,987
======

2015 
$000 

4,155 
391 
------------- 
4,546 
====== 

11. 

NON CURRENT LIABILITIES 

Group 

Company 

Warrants (note 14) 
Deferred rent liability 

2016 
$000 

35 
56 
------------- 
91 
====== 

2015 
$000 

2016 
$000 

685 
49 
------------- 
734 
====== 

35
56
------------
91
======

2015 
$000 

685 
49 
------------ 
734 
====== 

12. 

CALLED UP SHARE CAPITAL 

Issued and fully paid 

No of shares 

  Share Capital 

$ 

Akari Therapeutics Plc 
As at 1 January 2016 and 31 December 2016 

1,177,693,383 
============== 

18,340,894 
============= 

32 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
     
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

13. 

RESERVES 

The following describes the nature and purpose of each reserve within equity: 

Share  premium -  Accumulated amounts subscribed for share capital in excess of the nominal value of the share 
capital issued. 

Retained loss – Includes all current and prior period losses  

Other  reserves  -  Accounts  for  all  other  gains  and  losses  reported  by  the  group  and  not  recognised  elsewhere.  
Includes accumulated gains and losses arising from the retranslation of the net assets of overseas entities. 

Share based payment reserve – This includes all movement for share options granted during the period. 

Merger  reserve  –  Merger  reserve  represents  the  premium  on  the  shares  issued  to  acquire  Volution  Immuno 
Pharmaceuticals SA in accordance with the provisions of S612 of the Companies Act 2006. 

Reverse  acquisition  reserve  –  The  reverse  acquisition  reserve  relates  to  the  reverse  acquisition  between  Celsus 
Therapeutics PLC and  Volution Immuno Pharmaceuticals SA on 18 September 2015. 

14.  WARRANTS 

Upon completion of the Acquisition, the Company assumed certain warrants that were issued in connection with several 
private placements by the Company and certain investors where it sold ordinary shares and warrants. Some of the issued 
warrants contain non-standard anti-dilution clauses. 

As  of  18  September  2015,  the  Acquisition  date,  warrants  to  purchase  5,617,977  ordinary  shares  had  full  ratchet  anti-
dilution protection (which would be triggered by a share or warrant issuance at less than $0.1958 price share or exercise 
price per share). The issuance of ordinary shares in connection with the financing triggered the full ratchet anti-dilution 
protection  resulting  in  an  additional  188,303  ordinary  shares  issuable  upon  exercise  of  such  warrants  for  a  total  of 
5,806,280  and  reducing  the  exercise  price  to  $0.18945.    As  of  31  December  2016,  the  fair  value  of  the  warrants  was 
$34,838.  The  net  change  in  fair  value  was  recognised  as  change  in  fair  value  of  option  and  warrant  liabilities  in  the 
Group’s consolidated statement of comprehensive loss.  The warrants expired on 4 April 2017. 

The  Group  accounts  for  the liability  warrants  issued  in  accordance  with  IAS  39,  “’Financial  Instruments:  Recognition 
and Measurement” as a freestanding liability instrument that is measured at fair value at each reporting date, based on its 
fair value, with changes in the fair values being recognised in the Group's consolidated statement of comprehensive loss 
as financing income or expense.  

The fair value of warrants granted was measured using the Binomial method of valuation.  

Fair values were estimated using the following assumptions for the options as of 31 December 2016: 

Expected dividend yield 
Expected volatility 
Risk-free interest 
Expected life 

0 % 
73.39 % 
0.51 % 

    0.26 years  

The Group’s financial assets and liabilities measured at fair value on a recurring basis, consisted of the following types of 
instruments as of the following dates: 

Warrants (anti-dilution protection) 

33 

31 December      31 December    

2016 

2015 

$ 

34,838     $ 

685,141    

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
  
  
 
  
  
   
  
  
  
  
   
  
  
  
  
     
  
  
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

14.  WARRANTS (continued) 

Warrants to service providers and investors - 

The warrants acquired as part of the acquisition and outstanding as of 31 December 2016 are as follows: 

Grant date 
2012 warrants 

Number of 
warrants   
1,383,086  

2013 warrants 

399,160  

 $ 

 $ 

Exercise 
Price 
1.72 - $2.25  

Expiration date 
16 January 2017- 30 November 2017 

2.00  

16 January 2018-17 September 2018 

15 

SHARE OPTIONS 

As  part  of  the  business  combination,  the  Group  acquired  the  former  Company’s  2015  Equity  Incentive  Plan  (the 
“Plan”).  The  number  of  shares  that  may  be  issued  upon  exercise  of  options  under  the  Plan,  cannot  exceed 
141,142,420  shares.  As  of  31  December  2016,  61,770,222  Ordinary  shares  are  available  to  be  issued  to  certain 
employees or directors under the Plan rules.  The option plan is administered by the Group’s board of directors and 
grants are made pursuant thereto by the compensation committee.  The per share exercise price for the shares to be 
issued pursuant to the exercise of an option shall be such price equal to the fair market value of the Group’s ordinary 
shares on the grant date and set forth in the individual option agreement.  Options terminate ten years after the grant 
date and typically vest over three to four years. 

The following is a summary of the Group's share options granted separated into ranges of exercise price: 

Exercise 
price 
(range) 

Options 
outstanding 
as of 31 
December 
2016 

Weighted 
average 
remaining 
contractual 
life (years) 

Weighted 
average 
exercise 
price 

Options 
exercisable 
as of 31 
December 
2016 

Remaining 
contractual 
life (years for 
exercisable 
options 

Weighted 
average 
exercise 
price 

0.08-0.19 
0.32 
0.60-0.75 
1.19-1.56 
2.00 

24,313,351 
53,597,347 
290,000 
311,500 
860,000 
79,372,198 

9.31 
8.72 
7.2 
3.24 
6.73 

0.15 
0.32 
0.72 
1.31 
2.00 

6,950,054 
17,239,932 
290,000 
311,500 
695,000 
25,486,486 

9.22 
8.72 
8.23 
3.24 
6.73 

0.15 
0.32 
0.72 
1.31 
2.00 

On  23  March  2016,  the Company  granted  11,000,000  options  to  its  employees  at  an  exercise  price  of  $0.141  per 
share that vests semi-annually over four years. On 22 April 2016, the Company granted 1,300,000 options 
a 
director at an exercise price of $0.18 per share that vest annually over three years.  On  29  June  2016,  the  Company 
granted. 7,800,000 options to its directors at an exercise price of $0.145 per share, 6,500,000 which will vest in full 
on the date of the Company’s 2017 Annual General Meeting and 1,300,000 of which will vest over three years.  On 
13 October 2016, the Company granted 1,300,000 options to a  director  at  an  exercise  price  of  $0.080621  per  share 
which will vest equally over three years on the date of the Company’s 2017-2019 Annual General Meetings, with the 
first vesting on the date of the Company’s 2017 Annual  General  Meeting.    On  13  October  2016,  the  Company 
granted  1,  300,000  options  to  a  resigning  director  at  an  exercise  price  of  $0.080621  per  share  which  vested 
immediately upon grant. On October 13, 2016, the Company granted 1,300,000 options to a resigning director at an 
exercise price of $0.080621 per share which vested immediately upon grant. 

to 

The  Company  accounts  for  awards  of  equity  instruments  issued  to  employees  and  directors  under  the  fair  value 
method  of  accounting  and  recognise  such  amounts  in  its  Consolidated  Statements  of  Comprehensive  Loss.  The 
Company  measures  compensation  cost  for  all  share-based  awards  at  fair  value  on  the  date  of  grant  and  recognise 
compensation expense in its Consolidated Statements of Comprehensive Loss using the straight-line method over the 
service period over which it expects the awards to vest.  

34 

 
 
 
 
 
 
 
  
  
 
  
  
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

15.      SHARE OPTIONS (Continued) 

The  Company  accounts  for  awards  of  equity  instruments  issued  to  employees  and  directors  under  the  fair  value 
method  of  accounting  and  recognise  such  amounts  in  its  Consolidated  Statements  of  Comprehensive  Loss.  The 
Company  measures  compensation  cost  for  all  share-based  awards  at  fair  value  on  the  date  of  grant  and  recognise 
compensation expense in its Consolidated Statements of Comprehensive Loss using the straight-line method over the 
service period over which it expects the awards to vest.  

The  Company  estimates  the  fair  value  of  all  time-vested  options  as  of  the  date  of  grant  using  the  Black-Scholes 
option  valuation  model,  which  was  developed  for  use  in  estimating  the  fair  value  of  traded  options  that  have  no 
vesting  restrictions  and  are  fully  transferable.  Option  valuation  models  require  the  input  of  highly  subjective 
assumptions, including the expected share price volatility, which is calculated based on the historical volatility of the 
Company’s common share. The Company uses a risk-free interest rate, based  on the U.S. Treasury instruments in 
effect at the time of the grant, for the period comparable to the expected term of the option. Given its limited history 
with share option grants and exercises, the Company uses the “simplified” method in estimating the expected term, 
the period of time that options granted are expected to be outstanding, for its grants. 

The Company classifies its share-based payments as either liability-classified awards or as equity-classified awards. 
The Company remeasures liability-classified awards to fair value at each balance sheet date until the award is settled. 
The  Company  measures  equity-classified  awards  at  their  grant  date  fair  value  and  do  not  subsequently  remeasure 
them. The Company has classified its share-based payments which are settled in common share as equity-classified 
awards and share-based payments that are settled in cash as liability-classified awards. Compensation costs related to 
equity-classified  awards  generally  are  equal  to  the  grant-date  fair  value  of  the  award  amortised  over  the  vesting 
period of the award. The liability for liability-classified awards generally is equal to the fair value of the award as of 
the balance sheet date multiplied by the percentage vested at the time. The Company charges (or credits) the change 
in the liability amount from one balance sheet date to another to compensation expense.  Below are the assumptions 
used for the options assumed and granted in the year ended 31 December 2016:  

Expected dividend yield 
Expected volatility 
Risk-free interest 
Expected life 

2016 
0% 
   74.18%-80.71% 
   1.03%-1.52% 
   5.50-6.25 years 

During  the  year  the  Group  recognised  $3,933,000  in  share  based  compensation  expenses  for  employees  and 
directors. As of 31 December 2016, there was $8,957,000 unrecognised compensation cost relating to unvested share 
options granted under the Group’s share option plans. 

16.   FINANCIAL INSTRUMENTS 

a. 

Classification of financial assets and liabilities: 

The financial assets and financial liabilities in the statement of financial position are classified by groups of financial 
instruments pursuant to IAS 39 are:  

Financial assets: 
Other receivables 

Financial liabilities: 
Trade payables, other payables, warrants and other long term liabilities 

2016 
$000 

2015 
$000 

176 
======= 

2,407 
======= 

10 
======= 

5,055 
======= 

35 

 
 
 
 
 
 
 
 
 
 
  
  
  
  
  
 
  
 
  
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

16.   FINANCIAL INSTRUMENTS (continued) 

Financial risks factors: 

The  Group's  activities  are  exposed  to  foreign  exchange  risk.  The  Group's  comprehensive  risk  management  plan 
focuses  on  activities  and  strategies  that  reduce  adverse  effects  on  the  financial  performance  of  the  Group  to  a 
minimum.  

1. 

Foreign currency risk: 

Foreign  currency  risk  is  the  risk  that  the  fair  value  or  future  cash  flows  of  a  financial  instrument  will  fluctuate 
because of changes in foreign exchange rates. The Group's exposure to the risk of changes in foreign exchange rates 
relates primarily to the Group's operating activities when expenses are denominated in a different currency from the 
Group's functional currency. The Group believes that no reasonable change in foreign currency exchange rates would 
have a material impact on the income statement or statement  of changes in equity. The  Group manages its foreign 
currency  risk  by  managing  bank  accounts  that  are  denominated  in  a  currency  other  than  its  respective  functional 
currency, primarily the Great Britain Pound (GBP). 

2. 

Credit risk: 

Credit  risk  is  the  risk  that  a  counterparty  will  not  meet  its  obligations  under  a  financial  instrument  or  supplier 
contract,  leading  to  a  financial  loss.  Financial  instruments  that  potentially  subject  the  Group  to  concentrations  of 
credit  risk consist  principally  of cash and  cash equivalents.  Cash and cash  equivalents and  short-term  deposits  are 
deposited with major banks in Europe and the United States, and invested mostly in U.S. dollars and Great Britain 
Pounds. Such deposits may be in excess of insured limits and are not insured in other jurisdictions. Generally, these 
deposits may be redeemed upon demand and therefore bear low risk. 

3. 

Market risk: 

The Group's financial instruments comprise equity investments, cash  and  various items such as trade debtors and 
trade creditors that arise directly from its operations. The main risk arising from the Groups financial instruments is 
liquidity risk. The Group has not entered into any derivative transactions. 

17.  OPERATING LEASE COMMITMENTS 

The future minimum lease payable under non-cancelable office operating lease are as follows: 

2017 
2018 
2019  

Total 

London 
$000 

129 
129 
  26 
---------- 
   284 
===== 

United States 
$000 

313 
330 
225 
---------- 
868 
===== 

36 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2016 

18.      RELATED PARTY TRANSACTIONS 

The following transactions were carried out with related parties: 

Accounting  Services  -  An  entity  related  to  a  shareholder  provided  accounting  and  bookkeeping  services  of 
$45,000  and  $131,000,  respectively,  to  the  Group  during  the  years  ended  31  December 2016  and  2015, 
respectively. 

Other  –  At  31  December 2015,  there  was  a  receivable  balance  in  the  amount  of  $10,366  with  RPC  Pharma 
Limited  (“RPC”), a major  shareholder.  The  Group  paid certain registration  fees  on RPC’s  behalf and  is  treating 
this as short-term in nature with no interest. This amount is recorded under “Receivable from related party” within 
current assets on the statement of financial position. At 31 December 2016, the balance was $nil. 

Office Lease - A non-employee director of the Group is also the CEO of The Doctors Laboratory (“TDL”).  The 
Group  leases its  UK  office space  from  TDL  and  has  incurred expenses  of approximately $142,000 and  $10,000 
plus VAT during the years ended 31 December 2016 and 2015, respectively. 

19.       POST BALANCE SHEET EVENTS 

During April 2017, the Group granted 7,150,000 share options to certain employees. 

On  12  May  2017,  a  putative  securities  class  action  captioned  Derek  Da  Ponte  v.  Akari  Therapeutics,  PLC,  Gur 
Roshwalb,  and Dov Elefant (Case 1:17-cv-03577) was filed in the U.S. District Court for the Southern District of 
New  York  against  the  Company,  the  Company’s  Chief  Executive  Officer  and  the  Company’s  Chief  Financial 
Officer.   The  plaintiff  asserted  claims  alleging  violations  of  Sections  10(b)  and  20(a)  of  the  Securities  Exchange 
Act of 1934 based primarily on the Company’s press release issued on 27 April 2017 stating that investors should 
not rely on a research report about the Company prepared by a research company. The purported class covers the 
period  from  30  March  2017  to  11  May  2017.   The  action  seeks  unspecified  damages  and  costs  and  fees.   The 
Company intends to vigorously defend itself against this lawsuit.   At this time, the Company is unable to estimate 
the ultimate outcome of this legal matter and its impact on the Company. 

20. 

STANDARDS ISSUED BUT NOT YET EFFECTIVE 

Standards, amendments and interpretations issued but not yet effective up to the date of issuance of the Annual 
Report are listed below. This listing is of standards, amendments and interpretations issued, which the group 
reasonably expects to be applicable at a future date. The group intends to adopt those standards when they become 
effective. 

IFRS 15 ‘Revenue from contracts with customers’.  
IFRS 9 ‘Financial instruments’. 

 
 
  Amendment to IAS 1, ‘Presentation of financial statements’ on the disclosure initiative. 
 

IFRS 16 ‘Leases’. 

The impact on the Group’s financial statements of the future adoption of these and other new standards and 
interpretations is under review. With the exception of the IFRS 16 the Group does not expect the impact of such 
changes on the financial statements to be material. 

21.  ULTIMATE CONTROLLING PARTY 

The ultimate controlling party of the Group is RPC who holds a 61% stake in the Group. 

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