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Akari Therapeutics Plc

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FY2023 Annual Report · Akari Therapeutics Plc
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AKARI THERAPEUTICS, PLC  

ANNUAL REPORT AND CONSOLIDATED FINANCIAL STATEMENTS 

FOR THE YEAR ENDED  

31 DECEMBER 2023 

Registered in England and Wales, number: 05252842 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

CONSOLIDATED ANNUAL REPORT AND FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

CONTENTS 

Officers and professional advisers 

Directors’ report 

Strategic Report 

Director’s Remuneration Report 

Independent Auditor’s report to the shareholders of Akari Therapeutics Plc 

Consolidated statement of comprehensive loss 

Consolidated statement of financial position 

Parent company statement of financial position 

Consolidated statement of changes in equity 

Parent company statement of changes in equity 

Consolidated statement of cash flows 

Parent company statement of cash flows 

Notes to the report and financial statements 

Page 

1  

2  

6  

13  

30  

35 

36   

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38 

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40  

41  

42  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

OFFICERS AND PROFESSIONAL ADVISERS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Directors 

R Prudo-Chlebosz   
M Hashad 
D Williams  
M Grissinger  
S Patel 

Secretary                       

Prism Cosec Limited  

Registered Office 

Independent Auditors 

Highdown House, 
Yeoman Way,  
Worthing,  
West Sussex  
BN99 3HH  

Haysmacintyre LLP 
10 Queen Street Place 
London  
EC4R 1AG 

Unless the context otherwise requires, all references to “Akari,” “we,” “us,” “our,” the “Company”, the “Group” and similar 
designations  refer  to  Akari  Therapeutics,  Plc  and  its  subsidiaries.    All  references  to  “parent  company”  refer  to  Akari 
Therapeutics, Plc excluding its subsidiaries. 

The directors of the Company (“Directors”) present their report and the audited financial statements for the year ended 31 
December 2023. 

1 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

The Company has chosen, in accordance with section 414C(11) of the Companies Act 2006, to include in its strategic report 
the  following  matters  that  would  otherwise  be  required  to  be  disclosed  in  this  Directors’  report:  information  on  material 
financial instruments; information on research and development activities; and an indication of likely future developments in 
the business of the Company. 

PRINCIPAL ACTIVITY  

The principal activity of the Group is developing advanced therapies for autoimmune and inflammatory diseases involving 
the complement (C5) and leukotriene (LTB4) pathways. Each of these systems has scientifically well-supported causative 
roles  in  the  diseases  the  Company  is  targeting.  Management  believes  that  blocking  early  mediators  of  inflammation  will 
prevent  initiation  and  continual  amplification  of  the  processes  that  cause  certain  diseases.  The  Group’s  activities  since 
inception have consisted of performing research and development activities and raising capital. 

DIRECTORS 

The Directors who served the Company during the year and up to the date of signing the Annual Report were as follows: 

R Prudo-Chlebosz   
M Hashad (Appointed on 30 June 2023) 
D Williams  
M Grissinger  
R Jacques (Resigned on 7 May 2024) 
D Byrne (Resigned on 30 June 2023) 
J Hill (Resigned on 30 June 2023)  
S Ungar (Resigned on 30 June 2023) 
S Patel (Appointed 29 November 2023) 

DIRECTORS’ INDEMNITY 

The Company’s Articles of Association provide, subject to the provisions of UK legislation, an indemnity for directors and 
officers of the Company in respect of liabilities they may incur in the discharge of their duties or in the exercise of their 
powers, including any liabilities relating to the defence of any proceedings brought against them which relate to anything 
done or omitted, or alleged to have been done or omitted, by them as officers or employees of the Company. 

Appropriate directors and officer’s liability insurance cover is in place in respect of all Company directors. 

2 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

ENVIRONMENTAL DISCLOSURES 

We are a group with a small number of employees. We have serviced offices and we currently outsource our research, 
development, testing and manufacturing activities. As a result, the group itself consumed 40,000 kWh of energy or less 
during the year ended 31 December 2023. For this reason, no disclosures concerning greenhouse gas emissions, energy 
consumption and energy efficiency action are made under the Large and Medium-sized Companies and Groups (Accounts 
and Reports) Regulations 2008. 

AUDITORS 

Haysmacintyre LLP have indicated their willingness to continue in office as auditor for another year. In accordance with 
section 489 of the Companies Act 2006, a resolution proposing that Haysmacintyre LLP be reappointed as auditors of the 
Company will be put to the Annual General Meeting.  

SUBSTANTIAL SHAREHOLDERS 

On  31  December  2023  the  following  shareholders  held  an  interest  of  3%  or  more  of  the  ordinary  share  capital  of  the 
Company: 

Ray Prudo, M.D. (1) 
PranaBio Investments, LLC (2) 

Ordinary shares of $0.0001  % of issued share capital 
24.0% 
15.8% 

3,171,056,800 
2,085,237,500 

(1)  Represents  the  entire  holdings  of  RPC  Pharma  Limited,  Praxis  Trustees  Limited  As  trustee  of  The  Sonic  Healthcare  Holding 
Company  and  Dr.  Ray Prudo  as reported on  the  Amendment  No.  7  Schedule 13D  filed  with  the U.S.  Securities  and  Exchange 
Commission (“SEC”) on January 4, 2024. The principal business office of RPC Pharma Limited is c/o Landmark Fiduciare (Suisse) 
SA, 6 Place des Eaux-Vives, P.O. Box 3461, Geneva, V8 1211, Switzerland. Dr. Ray Prudo has shared voting and dispositive control 
over  the  ordinary  shares  held by  RPC  Pharma  Limited  and  owns  approximately 67.8%  of  RPC’s outstanding  shares  (including 
option grants), including 10.6% of RPC’s outstanding shares held in trust for Dr. Ungar. Dr. Prudo disclaims beneficial ownership 
except to the extent of his actual pecuniary interest in such shares. 

(2)  Represents the holdings of Pranabio Investments, LLC as reported on Form  4 filed with the SEC on January 2, 2024. Pranabio 
Investments, LLC is a Texas limited liability company. Samir R. Patel, M.D., is the managing member and has sole voting and 
investment power with respect to the shares. 

As at 31 December 2023 no other person had reported an interest of 3% or more in the Company’s ordinary shares. 

3 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

CORPORATE GOVERNANCE 

The Group is not required to implement the provisions of the UK Corporate Governance Code (the “Code”).  

Regular Board of Directors meetings are held. The Board of Directors meets regularly and is responsible for overseeing 
management, formulating strategy and monitoring the Group’s performance. 

GOING CONCERN 

The Group meets its day-to-day working capital requirements through funding. In assessing the Group’s ability to continue 
as a going concern, Management has prepared financial forecasts covering at least the next twelve months from the date of 
approval of the financial statements. 

The Group’s forecast and projections, show that at present, the Group has insufficient working capital to fulfil its current 
business plan without the Group raising additional capital. 

As of 31 December 2023, the Group’s cash balance was $3.8 million. To date, the Group has incurred substantial losses 
and negative cash flows since inception and had an accumulated deficit of $203.6 million as of 31 December 2023. 

The Group anticipates incurring additional losses until such time, if ever, that it can generate significant sales of its product 
candidates currently in development. The Group is subject to a number of risks and uncertainties similar to those of other 
companies of the same size within the biotechnology industry, such as uncertainty of clinical trial outcomes, uncertainty 
of additional funding, and history of operating losses. Substantial additional financing will be needed by the Group to fund 
its operations and to commercially develop its product candidates and there can be no assurance that additional funds will 
be available when the Group need them on terms that are acceptable to it, or at all. As of May 31, 2024, the Group’s cash 
balance of $5.9 million, which includes net proceeds received from the May 2024 Private Placement (see note 19 of the 
notes to financial statements), is not sufficient to fund its operations for the one-year period after the date these consolidated 
financial statements are issued.  

Management  is  currently  evaluating  different  strategies  to  obtain  the  required  funding  for  future  operations.  These 
strategies may include, but are not limited to: product development financing, private placements and/or public offerings 
of  equity  and/or  debt  securities,  and  strategic  research  and  development  collaborations  and/or  similar  arrangements. 
Further, closing of the Group’s proposed merger with Peak Bio, Inc. as contemplated in the associated Merger Agreement 
is  contingent  on  the  PIPE  Investment  (as  defined  in  the  Merger  Agreement)  which  shall  have  been  consummated 
simultaneously with, and conditioned only upon, the occurrence of the closing, and shall result in net proceeds to the Group 
of least $10 million. Management also expects that further sources of funding will also be made available for the Group to 
draw on (if required) as a result of the merger. 

While management is confident in the Company’s ability to obtain future funding, there can be no assurance that these 
future funding efforts, including the PIPE Investment (as defined in the Merger Agreement), will be successful. 
Based on the requirement for Group to raise additional capital to finance future operations and for it to manage its working 
capital position, particularly in relation to accounts payable balances, until further such capital can be raised, management 
has concluded that these outcomes represent material uncertainties that cast significant doubt regarding the Group’s ability 
to continue as a going concern within one year after the date that these consolidated financial statements are issued. 

Notwithstanding these uncertainties, the accompanying consolidated financial statements have been prepared assuming 
that we will continue as a going concern, which contemplates the realisation of assets and the satisfaction of liabilities in 
the normal course of business. As such, the accompanying consolidated financial statements do not reflect any adjustments 
relating to the recoverability and classification of recorded assets and liabilities that might be necessary if  the Group is 
unable to continue as a going concern. 

SUBSEQUENT EVENTS 

Events  occurring  after  the  year  end  and  required  to  be  disclosed  are  detailed  in  note  19  of  the  notes  to  the  financial 
statements.  

4 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

DIRECTORS’ REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

STATEMENT OF DIRECTORS’ RESPONSIBILITIES  

The Directors are responsible for preparing the Annual Report and the financial statements in accordance with applicable 
laws and regulations. 

Company law requires the directors to prepare Group and Parent company financial statements for each financial year. Under 
that  law  the  directors  have  elected  to  prepare  the  Group  and  Parent  company  financial  statements  in  accordance  with 
International Financial Reporting Standards (“IFRS”) as adopted by the United Kingdom. Under company law the directors 
must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of 
the Group and the Company and their profit or loss for that period. 

The financial  statements are required by law and IFRS as adopted by the United Kingdom to present fairly the financial 
position and performance of the Group. 

In preparing these financial statements the directors are required to: 
• 
• 
• 

select suitable accounting policies and then apply them consistently; 
make judgements and accounting estimates that are reasonable and prudent; 
state whether they have been prepared in accordance with IFRS as adopted by the United Kingdom subject to any 
material departures disclosed and explained in the financial statements; and 
prepare the financial statements on the going concern basis unless it is inappropriate to presume that the Group and 
the parent company will continue in business. 

• 

The directors are responsible for keeping proper accounting records which disclose with reasonable accuracy at any time 
the financial position of the Group and Parent company and to enable them to ensure that the financial statements comply 
with the Companies Act 2006 and Article 4 of the IAS Regulation.  They have general responsibility for taking such steps 
as are reasonably open to safeguard the assets of the Group and Parent company and to prevent and detect fraud and  
other irregularities.  

The directors consider that the Annual Report,  taken as a whole, is fair, balanced and understandable and provides the 
information necessary for shareholders to assess the Group’s performance, business model and strategy.  

DISCLOSURE OF INFORMATION TO AUDITORS 

Each of the directors at the time the report is approved confirms that, as at that time: 
•  so far as the director is aware, there is no relevant audit information of which the Company’s auditors are unaware; and 
• 
the director has taken all steps that they ought to have taken as a director to make themselves aware of  any relevant 
audit information and to establish that the Company’s auditors are aware of that information. 

This report was approved by the board on 3 June 2024 and signed on its behalf. 

Samir R. Patel 

Samir R. Patel                                                                                           
Director and Interim Chief Executive Officer

5 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

REVIEW OF BUSINESS 

The  Group  is  a  clinical-stage  biotechnology  company  focused  on  developing  advanced  therapies  for  autoimmune  and 
inflammatory diseases involving the complement (“C5”) and leukotriene (“LTB4”) pathways. Each of these pathways has 
scientifically well-supported causative roles in the diseases the  Group is targeting. Management believes that blocking 
early  mediators  of  inflammation  will  prevent  initiation  and  continual  amplification  of  the  processes  that  cause  certain 
diseases. The  Group’s  activities  since  inception  have  consisted  of  performing  research  and  development  activities  and 
raising capital. 

The  Group’s  lead  product  candidate,  nomacopan,  is  a  recombinant  small  protein  (16,769  Da)  derived  from  a  protein 
originally discovered in the saliva of the Ornithodoros moubata tick, which modulates the host immune system to allow 
the parasite to feed without alerting the host to its presence or provoking an immune response. Nomacopan is a second-
generation complement inhibitor which acts on complement C5, preventing release of C5a and formation of C5b–9 (also 
known as the membrane attack complex (“MAC”)), and also independently and specifically inhibit LTB4 activity, both 
elements that are often co-located as part of the immune/inflammatory response. Management believes the importance of 
nomacopan’s therapeutic potential is twofold. First, its dual inhibitory action may be able to prevent inflammatory and 
prothrombotic activities of two key pathways, and second, nomacopan’s bio-physical properties may allow it to be used in 
a variety of formulations and routes of administration, including subcutaneous, intravenous, topical to eye, inhaled and 
intravitreous. 

Up  until  May  2024,  the  Group  was  conducting  a  clinical  trial  of  subcutaneous  nomacopan  for  the  treatment  of 
hematopoietic  stem  cell  transplant-related  thrombotic  microangiopathy  (“HSCT-TMA”)  in  pediatrics.  Following 
completion of a portfolio prioritization review, the Group announced that its HSCT-TMA program will be suspended, as 
more fully described below. The Group is currently investigating long-acting PASylated-nomacopan (“PAS-nomacopan”) 
for  treatment  of  Geographic  Atrophy  (“GA”)  secondary  to  dry  age-related  macular  degeneration  (“dry  AMD”)  in 
preclinical studies and expect to hold a pre-investigational new drug application meeting in the third quarter of 2024. 

The  U.S.  Food  and  Drug  Administration  (“FDA”)  has  granted  Rare  Pediatric  Disease,  Orphan  Drug,  and  Fast  Track 
designations to nomacopan for the treatment of pediatric HSCT-TMA. Additionally, nomacopan has been granted Orphan 
Drug designation by the European Commission as a treatment for hematopoietic stem cell transplantation (“HSCT”). 

Merger Agreement and Pipeline Prioritization 

On March 5, 2024, Akari announced that it entered into an Agreement and Plan of Merger (the “Merger Agreement”) with 
Peak Bio, Inc. (“Peak Bio”) and Pegasus Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of Akari 
(“Merger Sub”), pursuant to which, upon the terms and subject to the conditions thereof, Merger Sub will be merged with 
and into Peak Bio (the “Merger”), with Peak Bio surviving the Merger as a wholly-owned subsidiary of Akari. 

On  May  1,  2024,  the  Group announced  the  completion  of  a  joint  portfolio  prioritization  review  pursuant  to  which  the 
anticipated combined entity, following completion of the previously announced Merger (as defined below), will focus on 
Peak Bio’s antibody drug conjugate (“ADC”) platform technology and the Group’s PAS-nomacopan GA program. As a 
result, the Group’s HSCT-TMA program will be suspended, with enrollment in its currently active pediatric clinical study 
discontinued due to cost and timeline. Following closing of the Merger, management plans to work closely with the FDA 
to define the best path for this technology and consider the opportunity for partnership and licensing, specifically as it 
relates  to  the  potential  eligibility  for  a  priority  review  voucher  in  connection  with  future  marketing  applications  for 
nomacopan, including as a treatment for pediatric HSCT-TMA. 

Also on May 1, 2024, management began to implement a reduction-in-force of approximately 67% of the Group’s total 
workforce, as a result of the recently announced program prioritization under which the Group’s HSCT-TMA program was 
suspended. The reduction-in-force is part of an operational restructuring plan and includes the elimination of certain senior 
management positions. The purpose of the restructuring plan, including the reduction-in-force, is to reduce HSCT-TMA 
related operating costs, while supporting the execution of our long-term strategic plan. 

6 

 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

RESULTS AND DIVIDENDS 

Research  and  development  expenses  for  the  year  ended  31  December  2023  were  approximately  $9,083,000  (2022: 
$10,816,000). The decrease was the result of the net impact of multiple factors. The Group’s research and development 
expenses decreased primarily due to decreases in clinical trial costs resulting from the Group’s decision to close the bullous 
pemphigoid (“BP”) trial in August 2022 and decreases in nompacopan manufacturing costs due to timing of manufacturing; 
partially offset by increases in personnel costs due to changes in our organizational structure, including a shift to U.S.-
based employees and consultants, and increases in external HSCT-TMA costs as a result of the prioritization of the HSCT-
TMA program in 2023.  

Administrative expenses for the year ended 31 December 2023 were approximately $11,358,000 (2022: $13,075,000). The 
decrease was the result of the net impact of multiple factors. The Group’s administrative expenses decreased   primarily 
due to decreases in (i) financing-related costs of approximately $1,700,000 as a result of costs incurred during the 2023 
period being classified in shareholders' equity, (ii) directors' and officers' insurance premiums of approximately $600,000, 
and (iii) personnel costs (including directors and consultants) of approximately $1,500,000. These decreases were partially 
offset  by  increases  in  other  expenses,  including  legal  and  professional  fees  of  approximately  $1,400,000,  of  which 
approximately $800,000 are costs incurred related to the proposed Merger.  

Net  cash  used  in  operating  activities  for  the  year  ended  31  December  2023  was  approximately  $17,440,000  (2022: 
$21,504,000). Net cash flow used in operating activities was primarily attributed to ongoing research activities to support 
nomacopan and PAS-nomacopan, including manufacturing, clinical trial and preclinical activities, as well as administrative 
expenses and the change in fair value of the warrants issued in 2022, which have been classified as liabilities. 

Net cash generated from financing activities was approximately $6,967,000 (2022: $25,288,000). 

Cash and cash equivalents decreased to approximately $3,845,000 at 31 December 2023 (2022: $13,250,000).    

The Group made a loss of approximately $12,240,000  (2022: $17,011,000). The loss for the Group is in line  with the 
expected performance and the Directors are satisfied with the results for the year. 

No dividends were paid during the year (2022: $Nil) and the Directors do not propose a final dividend. 

PRINCIPAL RISKS AND UNCERTAINTIES 

Financing 
The Group requires additional funding to continue its future operations and planned research and development activities.   
The Directors recognise that the Group may not be able to obtain financing on favorable terms and the terms of the Group’s 
finance arrangements may be dilutive. The Group may also seek additional funding through partnership arrangements with 
collaborators and other third parties.  These types of arrangements may require the Group to relinquish rights to internally 
developed technology, product candidates or products. If the Group is unable to obtain additional funding on a timely basis, 
the Group may be required to curtail or terminate some or all of its research or development programs, including some or 
all of its product candidates. Additionally, the report of the Group’s statutory audit firm on its financial statements for the 
period ended December 31, 2023, includes an explanatory paragraph raising substantial doubt about its ability to continue 
as a going concern as a result of recurring losses from operations and net capital deficiency. The Group’s future is dependent 
upon its ability to obtain financing in the future. This opinion could materially limit the Group’s ability to raise funds.  

The Group plans to raise additional funds through equity or debt financings or other sources, such as strategic partnerships, 
alliance and/or licensing arrangements and government grants. There can be no assurance that additional funds will be 
available when the Group needs them on terms that are acceptable, or at all. 

Clinical development stage 
The Company is a clinical development stage Group with limited history of trading on which future projections can be 
based.  There is no guarantee that the Group will succeed in growing its current business or that the Group will be able to 
provide or maintain sufficient resources required for operations in the development and introduction of its products. It is 
not unusual that clinical development stage companies fail to achieve their business  plans due to lack of being able to 
estimate the speed of new market entrants and the costs associated with entering markets and obtaining market share. 

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AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

PRINCIPAL RISKS AND UNCERTAINTIES (continued) 

Up until May 2024, the Group was conducting a clinical trial of subcutaneous nomacopan for the treatment of HSCT-TMA 
in pediatrics. Following completion of a portfolio prioritization review, the Group announced that its HSCT-TMA program 
will  be  suspended.  The  Group  is  currently  investigating  long-acting  PASylated-nomacopan  (“PAS-nomacopan”)  for 
treatment of GA secondary to dry AMD in preclinical studies. 

Drug development 
The Group’s drug development activities are complex, and all of the product candidates are in clinical development with a 
significant risk of failure.  It is impossible to predict when or if any of the product candidates will prove effective or safe 
in humans and/or will receive regulatory approval. 

Further common challenges for similar companies and the Group is to: 

•  Find a stable active product or formulation without extensive clinical trials and substantial additional 

costs or create adequate assays for the products for formulations or clinical testing purposes; 

•  Manufacture, and/or formulate sufficient amounts of its product candidates or upscale or optimise such 

synthesis so as to enable efficient production of scale; 

•  Find safe and effective doses for its product candidates without extensive clinical trials and substantial 

additional costs; 

•  Obtain sufficient supply or quality of product candidates supply or materials to produce product 

candidates or other materials necessary to conduct clinical trials; and 

•  Establish manufacturing capabilities or enter into agreements with third parties to supply materials in a 

timely fashion to make product candidates, or manufacture clinical trial drug supplies. 

Departure of and search for executive officers 
The  Group’s  success  depends  upon  the  continued  service  and  performance  of  our  senior  management  and  other  key 
personnel. The loss of the services of these personnel could delay or prevent the successful completion of our planned 
clinical trials or the commercialization of our therapeutic candidates or otherwise affect our ability to manage our company 
effectively and to carry out our business plan. The Group does not maintain key-man life insurance. Although the Group 
has  entered  into  employment  agreements  with  all  the  members  of  its  senior  management  team,  members  of  its  senior 
management  team  may  resign  at  any  time.  High  demand  exists  for  senior  management and other  key  personnel  in  the 
biopharmaceutical industry. There can be no assurance that the Group will be able to continue to attract and retain such 
personnel. 

Market acceptance 
The Group is not guaranteed that any of its product candidates will gain market acceptance amongst physicians, patients, 
healthcare providers, pharmaceutical companies or other customers. 

The Group’s clinical trials in humans may show that the doses selected based on screening, animal testing or clinical trials 
do not achieve the desired therapeutic result in humans, or achieve these results only in a small part of the population.  The 
U.S. Food and Drug Administration (“FDA”) or other regulatory agencies in the United States and foreign jurisdictions 
may determine that these clinical trials do not support the Group’s conclusion.  The Group may be required to conduct 
additional  clinical  studies  and  provide  more  evidence  substantiating  the  safety  and  efficacy  of  the  doses  selected  in  a 
significant patient population. 

8 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

PRINCIPAL RISKS AND UNCERTAINTIES (continued) 

Intense competition from larger competitors 
Many  companies,  universities  and  research  organisations  developing  product  candidates  have  greater  resources  and 
significantly greater experience in financial, research and development, manufacturing, marketing, sales, distribution and 
technical regulatory matters than the Group has. These competitors could commence and complete clinical testing of their 
products, obtain regulatory approval, and begin commercial-scale manufacturing of their products faster than the Group is 
able to, thus resulting in a situation whereby the Group may not be able to commercialise its product candidates or achieve 
a competitive position in the market. 

Product liability exposure 
The Group faces exposure to product liability and other claims if its product candidates, products or processes are alleged 
to have caused harm.  These risks are inherent in testing, manufacturing, and marketing human therapeutic products.  If the 
Group is sued for any injury caused by its products, product candidates or processes, the Group’s liability could exceed its 
product liability insurance coverage and its total assets. Claims against the Group, regardless of their merit or potential 
outcome,  may  also  generate  negative  publicity  or  damage  the  Group’s  ability  to  obtain  physician  endorsement  of  its 
products or expand its business. 

Intellectual property 
The Group may be unable to protect the intellectual property relating to its product candidates, or if it infringes the rights 
of others, its ability to successfully commercialise its product candidates may be harmed.  The Group owns or hold licenses 
to a number of issued patents (foreign and foreign counterparts) and pending patent applications.  The Group’s success 
depends in part on its ability to obtain patent protection both in the United States and in other territories for its product 
candidates,  as  well  as  the  methods  for  treating  patients  in  the  product  indications  using  these  product  candidates.  The 
Group’s ability to protect its product candidates from unauthorised or infringing use by third parties depends in substantial 
part on its ability to obtain and maintain valid and enforceable patents. Due to evolving legal standards relating to the 
patentability, validity and enforceability of patents covering pharmaceutical inventions and the scope of claims made under 
these patents, the Group’s ability to obtain, maintain and enforce patents is uncertain and involves complex legal and factual 
questions. Even if the Group’s product candidates, as well as methods for treating patients for prescribed indications using 
these product candidates are covered by valid and enforceable patents and have claims with sufficient scope, disclosure 
and support in the specification, the patents will provide protection only for a limited amount of time. Accordingly, rights 
under  any  issued  patents  may  not  provide  the  Group  with  sufficient  protection  for  a  commercial  advantage  against 
competitive products or processes. 

FINANCIAL INSTRUMENTS 

The Group finances its operations using cash generated by the sale of equity instruments in the Group.  The cash flow of 
the Group is monitored on a regular basis to ensure the Group has sufficient funding to meet its capital and operational 
requirements. 

RESEARCH AND DEVELOPMENT 

The Group is a clinical-stage biopharmaceutical company focused on developing advanced therapies for autoimmune and 
inflammatory  diseases,  specifically  through  the  inhibition  of  the  complement  and  leukotriene  pathways.  Each  of  these 
systems has scientifically well-supported causative roles in the diseases the Group is targeting. 

KEY PERFORMANCE INDICATOR  

The Directors consider the key performance indicator to be the Group’s cash position.  This allows the Directors to manage 
the on-going activities and strategies for further development of the Group.  

The key performance indicator is measured and reviewed on a regular basis at Board meetings and enable the Directors to 
communicate the performance of the Group against predetermined targets.  

9 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Key performance indicator:  

Operational key performance indicators relate to R&D activities and are discussed in the preceding elements of this report. 
Financially, the Group's key performance indicator is cash and utilisation thereof. As at the year ended 31 December 2023, 
the Group’s cash position was $3,845,000 (2022: $13,250,000). Further analysis of changes in the year is provided in the 
Group Statement of Cash Flows. 

EMPLOYEES 

As at 31 December 2023, we had 12 full-time employees. The table shows the number of staff of each gender employed at 
the Company and their level of seniority.  

Directors 
Senior Managers 
Employees 

Male 
5 
2 
3 

Female 
1 
1* 
5 

Total 
6 
3 
8 

* Excludes our President, Chief Executive Officer and director as of 31 December 2023, who is reflected in the Directors 
level. 

SECTION 172 STATEMENT  

When making decisions, the Directors act in the way they consider is most likely to promote the success of the Company, 
for the benefit of its members as a whole, while also considering the broad range of stakeholders who interact with the 
business.  

Our strategy is to develop and commercialize advanced therapies for autoimmune and inflammatory diseases.   

In striving to achieve the goal to develop new therapeutic medicines, the business touches the lives of many people. The 
Group  exists  in  a  complex  and  evolving  regulatory  and  scientific  environment  and  as  a  result  has  a  number  of  key 
stakeholder groups. Considering the interests of its stakeholders is fundamental to the way in which the Company operates. 
Our values and Code of Ethics empower employees to make the best decisions in the interest of the  Company and its 
stakeholders,  and  help  to  ensure  that  these  considerations  are  made  not  only  at  Board  level,  but  throughout  the  entire 
organization.  

Post  the  reporting  period  end,  the  Directors  of  the  Company  have  continued  to  take  into  account  the  Company’s 
stakeholders, including the potential impact of its future activities on the community, the environment and the Company’s 
reputation when making decisions. The Directors also continue to take all necessary measures to ensure the Company is 
acting in good faith and fairly between members and is promoting the success of the Company for its members in the long 
term. 

The table below serves as our Section 172 statement by setting out the key stakeholder groups, their interests and how the 
Company engages with them. Akari’s key stakeholders include its investors, employees, regulatory bodies and suppliers. 

10 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Stakeholder  

Why Akari engages  

How Akari engages  

Investors 

Employees  

Management maintains a regular and 
constructive dialogue with existing and 
potential investors to communicate the 
Company’s strategy and performance to 
promote investor confidence and ensure 
continued access to capital. 

Akari employees are key to the 
Company’s success and to the 
achievement of business objectives. 
Akari aims to be a responsible employer 
in our approach to employee 
engagement, development, performance 
and rewards.  The health, safety and 
well-being of the Group’s employees is 
one of Akari’s primary considerations 
in the way the Company does business.  
Employee engagement is led primarily 
by the CEO (or interim CEO) and the 
Executive Team.  

•  Annual General Meetings 
•  Financial reports filed with the SEC 
•  One-to-one meetings by 

Management with analysts and 
investors 

•  Investor outreach programs 

including attending virtual and in-
person conferences, events and 
roadshows 
•  Press releases 
•  Company website 
•  Social media (e.g. LinkedIn, 

Twitter) 

•  Market competitive compensation 
and benefits aligned with role and 
overall performance 

•  Individual development through 
coaching, on-the-job learning, 
external conferences and training 
opportunities 

•  Communication channels between 
the Board, Executive Team and 
Akari employees 

Regulatory bodies  

Akari is subject to a wide range of laws, 
regulations, and listing requirements 
including the regulatory framework 
from FDA, EMA and other regulatory 
agencies, the SEC, data protection, 
employment, tax, environmental and 
health and safety legislation.  

•  Company website 
•  SEC filings  
•  Annual Report 
•  Direct contact and 

communications with regulators  

•  Compliance updates at Board 

Meetings  

11 

 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

STRATEGIC REPORT 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Stakeholder  

Why Akari engages  

How Akari engages  

Suppliers  

Akari has several key suppliers 
with whom the Company has built 
strong relationships. Akari has 
established communication 
channels to ensure its working 
relationship remains collaborative 
and forward – focused, and to 
create a successful and fair 
collaboration.    

•  Building strong working 

relationships with suppliers 
through open two-way 
discussions and regular 
meetings. 

•  Executing contracts that guide 
expectations of both Akari and 
the suppliers. 

This report was approved by the Board on 3 June 2024 and signed on its behalf. 

Samir R. Patel 

Samir R. Patel, M.D.  
Director and Interim Chief Executive Officer 

12 

 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT  

FOR THE YEAR ENDED 31 DECEMBER 2023 

PART I - ANNUAL REPORT ON REMUNERATION 

Single Total Figure of Remuneration for Each Director  

The following table shows the compensation paid or accrued during the fiscal year ended 31 December 2023. 

Name of 
Director 

Salary 
and/or Fees 
($) 

Other 
compensati
on ($) 

Bonus ($) 

RSU 
Awards 
($)(1) 

Option 
Awards 
($)(2) 

Pension 
Benefits 
($)(3) 

2023 Total 
($) 

2023 
Total 
Fixed ($) 

2023 
Total 
variable 
($) 

Executive Director 

615,750  

Rachelle  
Jacques  
Non-Executive Director 

Ray Prudo, 
M.D.(4) 

Michael 
Grissinger 

Samir Patel, 
M.D(5) 

Mohamed 
Wa’el 
Ahmed 
Hashad(6) 
Donald 
Williams 

James Hill, 
M.D.(7) 

Stuart 
Ungar, 
M.D.(7) 

David 
Byrne(7) 

100,000 

60,350  

3,704 

28,684 

65,280  

29,343  

23,645  

49,170  

- 

-  

- 

- 

- 

-  

-  

-  

-  

-  

-  

-  

- 

- 

-  

-  

-  

-  

729,393  

198,498 

16,500 

1,560,141  

615,750  

945,391  

-  

-  

- 

- 

-  

-  

-  

-  

13,000  

6,500  

6,103 

6,500 

6,500  

-  

-  

-  

-  

-  

- 

 - 

-  

-  

-  

-  

113,000  

100,000  

13,000  

66,850  

60,350 

6,500  

9,807 

3,704 

6,103 

35,184 

28,684 

6,500 

71,780 

65,280  

6,500  

29,343 

29,343 

  -  

23,645 

23,645 

-  

49,170 

49,170  

-  

(1) Represents the aggregate grant date fair value of time-based restricted stock units (“RSUs”) issued under our 2014 Equity Incentive Plan (the “2014 
Plan”) and/or 2023 Equity Incentive Plan (the “2023 Plan”) in accordance with IFRS 2, Share-based payment. 

(2) Represents the aggregate grant date fair value of options to purchase ordinary shares issued under our 2014 Plan and/or 2023 Plan in accordance with 
IFRS 2, Share-based payment. 

(3) Consists of company contributions to U.K. pension scheme or the U.S. 401k Plan. 

(4) Dr. Prudo served as our Executive Chairman from September 2015 through December 2022. Effective January 1, 2023. Dr. Prudo began serving as 
the Chairman of our board of directors with a renumeration package of $100,000 per annum, paid in equal monthly installments. 

(5) Dr. Patel was appointed to our board of directors effective November 29, 2023. Dr. Patel has served as a member of our compensation committee 
since January 30, 2024. 

(6) Mr. Hashad was appointed to our board of directors effective June 30, 2023, at our 2023 annual general meeting. Mr. Hashad has served as a member 
of our audit committee and nominating and corporate governance committee since June 30, 2023.  

(7) Served as a director until our 2023 annual general meeting on June 30, 2023. 

13 

 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

The following table shows the compensation paid or accrued during the fiscal year ended 31 December 2022. 

Name of 
Director 

Salary 
and/or 
Fees ($) 

Other 
Compensa
tion ($) 

Bonus 
($)(6) 

Long-term 
Incentive 
($) 

Option 
Awards 
($)(1) 

Pension 
Benefits 
($) (4) 

2022 Total 
($) 

2022 Total 
Fixed ($) 

2022 
Total 
variable 
($) 

Executive Director 

Ray Prudo, 
M.D. (2) 

Rachelle  
Jacques  
(3) 
Clive 
Richardson (7) 

412,000 

458,333 

- 

- 

206,000 

875,000 

118,195 

14,595  

657,764 

(7) 

(5) 

(7) 

Non-Executive Director 

James Hill, 
M.D. 

Stuart Ungar, 
M.D. 

61,502 

49,064 

David Byrne 

58,332 

Donald 
Williams 

Peter 
Feldschreiber 
(8) 

Michael 
Grissinger 

56,838 

24,974 

41,505 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

618,000 

412,000 

206,000 

2,799,224 

15,250 

4,147,808 

3,922,808 

225,000 

- 

11,819 

802,373 

144,609 

657,764 

20,278 

20,278 

20,278 

20,278 

- 

20,278 

- 

- 

- 

- 

- 

- 

81,780 

81,780 

69,342 

69,342 

78,610 

78,610 

77,116 

77,116 

24,974 

24,974 

61,783 

61,783 

- 

- 

- 

- 

- 

- 

(1) These amounts represent the aggregate grant date fair value for option awards for fiscal year 2022 computed in accordance with IFRS 2, Share-based 
payment. A discussion of the assumptions used in determining grant date fair value may be found in note 16 to the Financial Statements. In addition to 
her stock option awards, Ms. Jacques received a restricted stock award whose grant date fair value was $253,410.   

(2) Dr. Prudo served as Executive Chairman of Akari’s Board of Directors from September 2015 until December 2022 and assumed the role of non-
executive Chairman of the Board effective January 1, 2023. 

(3) Ms. Jacques was appointed our President and Chief Executive Officer in March 2022. Ms. Jacques received a sign-on bonus in the amount of $650,000. 

(4) Consists of company contributions to U.K. pension scheme or the U.S. 401k Plan. 

(5) Consists of company contributions to health benefits of $11,897 and life insurance premiums of $2,698. 

(6)  Bonuses are awarded on the basis of an assessment of the overall performance of the executive director concerned, rather than specific measures or 
targets. In respect of 2022, the annual bonus payment for Mr. Prudo reflects his strong personal performance at a critical time for the business. The 2022 
annual bonus payment for Ms. Jacques was based on the Company’s performance against Company objectives agreed by the Board. Ray Prudo and 
Rachelle Jacques both received annual bonus payments of 100% of their target cash bonuses respectively, of which 100% was paid in the first quarter of 
2023. None of the awards is attributable to share price appreciation and no discretion was exercised because of share price appreciation or depreciation. 
Non-executive directors are not eligible to receive bonuses. 

(7) Mr. Richardson resigned as Chief Executive Officer and Chief Operating Officer in March 2022. Prior to his resignation, Mr. Richardson received 
three months of salary in the amount of $118,000. After his resignation, Mr. Richardson received a cash termination payment of approximately $658,000. 
In addition, Mr. Richardson entered into a consulting agreement with the Company in which Mr. Richardson earned approximately $305,000. 

(8) Mr. Feldschreiber resigned from the Board, effective 3 June 2022.  

15 

 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Incentive Plan Awards  

Akari has two compensation plans under which our equity securities are authorized for issuance (the 2014 Equity 
Incentive Plan and the 2023 Equity Incentive Plan) under which directors receive options to acquire ordinary shares in 
Akari. Upon effectiveness of the 2023 Plan Incentive Plan in June 2023, no further awards are available to be issued 
under the 2014 Plan. As of December 31, 2023, the Company had 789,393,500 ordinary shares underlying outstanding 
equity awards under the 2014 Plan, consisting of stock options and restricted stock units. 

Options and restricted stock units granted during the fiscal year ended 31 December 2023 are as follows: 

Name of Director 

Award 
Type 

Number of 
Awards (1) 

Grant Date 

Exercise 
Price ($) 

Face Value 
($) (2) 

Vesting 
Date 

Expiry 
Date 

Rachelle Jacques 

RSU 

189,787,200 

28/03/2023 

N/A 

358,698 

(3) 

28/03/2033 

Option 

152,690,700 

01/06/2023 

0.0016 

245,832 

(4) 

01/06/2033 

RSU 

190,798,825 

30/06/2023 

N/A 

324,358 

(5) 

30/06/2033 

Ray Prudo, M.D. 

Option 

10,000,000 

30/06/2023 

0.0017 

17,000 

(6) 

30/06/2033 

Michael Grissinger 

Option 

5,000,000 

30/06/2023 

0.0017 

8,500 

(6) 

30/06/2033 

Samir Patel, M.D. 

Option 

5,000,000 

29/12/2023 

0.0016 

7,800 

(6) 

29/12/2033 

Mohamed Wa’el 
Ahmed Hashad 

Option 

5,000,000 

30/06/2023 

0.0017 

8,500 

(6) 

30/06/2033 

Donald Williams 

Option 

5,000,000 

30/06/2023 

0.0017 

8,500 

(6) 

30/06/2033 

James Hill, M.D. 

N/A 

Stuart Ungar, M.D. 

N/A 

David Byrne 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

(1) Option and restricted stock unit awards are subject to time-based vesting conditions without performance measures or targets other than continued 
service until the date of vesting.  

(2) These amounts represent the face value for options awards, calculated as the number of shares awarded (assuming full vesting) multiplied by the 
price per share implied by the market price per ADS, which is equal to the stated exercise price.   

(3) The restricted stock unit award vests 50% on the first anniversary date of the date of grant, or 28 March 2024, with the remainder vesting in twelve 
equal monthly installments thereafter, subject to continued service. 

(4) The stock option award vests and becomes exercisable ratably on a semiannual basis over a four-year period commencing on 01 June 2023, subject 
to continued service. 

(5) The stock restricted stock award vests and becomes exercisable ratably on a semiannual basis over a four-year period commencing on 30 June 2023, 
subject to continued service. 

(6) The stock option award’s vests and becomes exercisable on the date of our 2024 Annual General Meeting, or by 30 June 2024. 

15 

 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Directors’ shareholdings  

The  table  below  shows,  for  each  director,  the  total  number  of  ordinary  shares  owned  (by  the  director  and  connected 
persons),  the  total  number  of  unvested  restricted  stock  units  held,  the  total  number  shares  issuable  upon  exercise  of 
outstanding warrants, and the total number of share options that were held and the number of share options vested as at 31 
December 2023. All unvested restricted stock units and share options are subject to time-based vesting without performance 
measures  or  targets  other  than  continued  service  until  the  date  of  vesting.  No  director  exercised  any  share  options  or 
warrants during the year ended 31 December 2023. 

Ordinary Shares 
Owned(1) 

Unvested 
Restricted Stock 
Units 

Share 
Warrants 

Share Options 

Vested Share 
Options 

Name of Director 

Executive Director 

Ray Prudo, M.D.(2) 

3,171,056,800 

- 

313,901,100 

10,000,000 

- 

Rachelle Jacques 

152,502,975 

385,954,925 

Non-Executive Director 

Michael Grissinger 

20,000,000 

Samir Patel, M.D.(3) 

2,085,237,500 

Mohamed Wa’el 
Ahmed Hashad 

- 

Donald Williams 

20,000,000 

James Hill, M.D 

Stuart Ungar, M.D. 

David Byrne 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

390,087,400 

108,110,100 

16,500,000 

11,500,000 

521,774,000 

5,000,000 

5,000,000 

- 

- 

19,850,000 

14,850,000 

- 

- 

- 

- 

- 

- 

(1) Our shareholders, named executive officers and directors may hold ordinary shares, ADS or a combination of both. This column shows each holder’s 
ownership assuming all shares were held as ordinary shares, which may not be the case. Our ADSs are listed on The Nasdaq Capital Market under the 
trading symbol “AKTX.” Ordinary shares are convertible to ADSs at a 2,000 to one ratio. 

(2) Amounts include holdings of RPC Pharma Limited (“RPC”), together with Ray Prudo, M.D. and Praxis Trustees Limited as trustee  of The Sonic 
Healthcare Holding Company (“Praxis,” and together with Ray Prudo  and RPC, “Ray Prudo and Affiliates”). In his individual capacity, Dr. Prudo 
beneficially owns the 3,484,957,900 Ordinary Shares (inclusive of 304,690,600 and 9,210,500 Ordinary Shares issuable upon exercise of warrants held 
by Dr. Prudo and RPC Pharma, respectively). RPC beneficially owns 809,977,100 Ordinary Shares (inclusive of 9,210,500 Ordinary Shares issuable 
upon exercise of warrants). Praxis beneficially owns 38,709,600 Ordinary Shares. Voting and investment decisions with respect to shares owned by 
RPC and Praxis are controlled by Dr. Prudo. 

(3) Dr. Patel is principal of PranaBio Investments, LLC. Share warrants held by PranaBio Investments, LLC consists of (i) prefunded warrants exercisable 
to purchase 96,774,000 ordinary shares (represented by 48,387 ADSs) at an exercise price of $0.0001 per ordinary share (or $0.20 per ADS), and (ii) 
warrants exercisable to purchase 425,000,000 ordinary shares (represented by 212,500 ADSs) at exercise prices ranging from $0.0016 to $0.03 per 
ordinary share (or $17.00 to $60.00 per ADS). 

16 

 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Illustration of Total Shareholder Return 

The following graph compares the cumulative total shareholder return on Akari’s ADSs, each representing 2,000 ordinary 
shares, with that of the NASDAQ Biotech Index (^NBI) from the period that Akari’s ADSs were publicly traded on The 
Nasdaq Capital Market through 31 December 2023. Akari selected the NASDAQ Biotech Index because Akari’s ADSs 
trade on The NASDAQ Capital Market and Akari believes this indicates its relative performance against a group consisting 
of more similarly situated companies. 

17 

 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Chief Executive Total Remuneration History 

The table below sets out total remuneration details for the Chief Executive Officer. 

Period 

2023 Rachelle Jacques 
2022 Rachelle Jacques (3) 
2022 Clive Richardson (5) 
2021 Clive Richardson 
2020 Clive Richardson 
2019 Clive Richardson (6) 
2018 (David Solomon) (7) 
2017 (Gur Roshwalb and 
David Solomon) (7) 
2016 (Gur Roshwalb) 
2015 (Gur Roshwalb) 
2014 (Gur Roshwalb) 
2013 (Gur Roshwalb) (8) 

Single total 
figure of 
remuneration 
($) 
615,750 
4,147,808 
802,373 
612,047 
503,941 
432,408 
173,611 
1,338,253 

581,250 
7,306,951 
410,564 
576,389 

Short-term 
incentive payout 
against 
maximum (1) 
- 

- 
- 
- 
- 
- 
100% (10) 

125% (11) 
100% (12) 
- 
- 

Option and 
restricted stock 
awards ($) 
927,891 (13) 
2,799,224 (4) 
- 
- 
- 
- 
- 
- 

- 
6,863,034 
60,564 
173,396 

Bonus ($) 
- 
875,000 (3) 
657,764 (5) 
206,826 
214,960 
177,028 
- 
119,041 (9) 

187,500 
86,625 
- 
- 

Option 
Awards 
against 
maximum (2) 
- 

- 
- 
- 
- 
- 
- 

- 
- 
- 
- 

(1)  All cash bonuses to Rachelle Jacques and Clive Richardson were awarded on a discretionary annual basis, except Ms. Jacques’s sign-on bonus.  

(2)  All options were awarded on a discretionary basis. 

(3)  Rachelle Jacques was appointed as Akari’s Chief Executive Officer on 28 March 2022. Ms. Jacques’s bonus includes a $650,000 sign-on bonus. 

(4) 

In addition to Ms. Jacques’s stock option awards granted during 2022, Ms. Jacques received a restricted stock award whose grant date fair value 
was $253,410. 

(5)  Mr. Richardson resigned as Akari’s Chief Executive Officer and Chief Operating Officer in March 2022. Mr. Richardson received a termination 

payment of $657,746. 

(6)  Clive Richardson was appointed Interim Chief Executive on 8 May 2018 and Chief Executive Officer on 18 July 2019.  

(7)  Dr. Roshwalb resigned as Akari’s Chief Executive Officer on 29 May 2017 and David Solomon was appointed as Akari’s Chief Executive 

Officer on 28 August 2017 and resigned 8 May 2018. 

(8)  Dr. Roshwalb was appointed as Akari’s Chief Executive Officer on 4 March 2013. 

(9) 

Includes a $50,000 signing bonus. 

(10)  Bonus was awarded in 2017 but calculated from Dr. Solomon’s appointment on 28 August 2017. 

(11)  Bonus was awarded in 2016 but calculated for a 15-month period from the date of the acquisition of Volution Immuno Pharmaceutical SA on 18 

September 2015.  

(12)  Bonus was awarded in 2015 but calculated for a 9-month period until the date of the acquisition of Volution Immuno Pharmaceutical SA on 18 

September 2015.  

(13)  In addition to Ms. Jacques’s stock option awards granted during 2023, Ms. Jacques received a restricted stock awards with a grant date fair value 

of $729,393 in the aggregate. 

18 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Directors’ Remuneration Compared to Other Employees 

The table below shows the percentage change in remuneration of each director and the parent company’s non-executive 
directors on a full-time equivalent basis between the year ended 31 December 2022 and the year ended 31 December 
2023. 

Change in Remuneration in year ended 31 December 2022 compared with 
remuneration in the year ended 31 December 2023 

Salary and/or Fees 

Taxable Benefits 

Annual Bonus 

Executive Director 
Ray Prudo, M.D. 
Rachelle Jacques  
Non-Executive Director 
James Hill, M.D. 
Stuart Ungar, M.D. 
David Byrne 
Donald Williams 
Mohamed Wa’el Ahmed Hashad 
Michael Grissinger 
Samir Patel, M.D. 
Other Employees 

-76%(1) 
34%(2) 

-52%(3) 
-52%(3) 
-16%(3) 
15%(4) 
- 
45%(5) 
- 
1% 

- 
- 

- 
- 
- 
- 
- 
- 
- 
- 

-100% 
-100% 

- 
- 
- 
- 
- 
- 
- 
-100% 

(1) Dr. Prudo served as our executive chairman from 2015 September through 2022 December. Effective 1 January 2023, Dr. Prudo began serving as the 
Chairman of our board of directors with a renumeration package of $100,000 per annum, paid in equal monthly installments. 

(2) Rachelle Jacques was appointed as Akari’s Chief Executive Officer on 28 March 2022. Accordingly, the increase is primarily due to renumeration 
during the year ended 31 December 2023 being for twelve months versus nine months for the year ended 31 December 2022. 

(3) Served as a director until our 2023 annual general meeting on 30 June 2023. Accordingly, the decrease is primarily due to a partial year of service for 
the year ended 31 December 2023. 

(4) Mr. Williams was appointed chairman of the compensation committee on 30 June 2023 which increased his annual retainer. 

(5) Mr. Grissinger was appointed to the compensation and audit committees on 1 November 2022 and our as chairman of the nominating and governance 
committee on 30 June 2023 which increased his annual retainer. 

19 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Directors’ Remuneration Compared to Other Employees (continued) 

The table below shows the percentage change in remuneration of each director and the parent company’s non-executive 
directors on a full-time equivalent basis between the year ended 31 December 2021 and the year ended 31 December 
2022. 

Executive Director 
Ray Prudo, M.D. 
Rachelle Jacques  
Clive Richardson  
Non-Executive Director 
James Hill, M.D. 
Stuart Ungar, M.D. 
David Byrne 
Donald Williams 
Peter Feldschreiber 
Michael Grissinger 
Other Employees 

Change in Remuneration in year ended 31 December 2021 compared with 
remuneration in the year ended 31 December 2022 

Salary and/or Fees 

Taxable Benefits 

Annual Bonus 

0% 
(1) 
-78% (2) 

- 
- 
- 
- 
- 
- 
2% 

- 
(1) 
-3% 

- 
- 
- 
- 
- 
- 
76% 

0% 
(1) 
-100% (2) 

- 
- 
- 
- 
- 
- 
-34% 

(1) Rachelle Jacques was appointed as Akari’s Chief Executive Officer on 28 March 2022; there is no comparison. 

(2) Mr. Richardson resigned as Akari’s Chief Executive Officer and Chief Operating Officer in March 2022. Mr. Richardson received three months of 
salary in 2022; he did not receive a 2022 bonus. 

The table below shows the percentage change in remuneration of each director and the parent company’s non-executive 
directors on a full-time equivalent basis between the year ended 31 December 2020 and the year ended 31 December 2021. 

Change in Remuneration in year ended 31 December 2020 compared with 
remuneration in the year ended 31 December 2021 

Salary and/or Fees 

Taxable Benefits 

Annual Bonus 

Executive Director 
Ray Prudo, M.D. 
Clive Richardson 
Non-Executive Director 
James Hill, M.D. 
Stuart Ungar, M.D. 
David Byrne 
Donald Williams 
Peter Feldschreiber 
Michael Grissinger 
Other Employees 

- 
5% 

- 
- 
- 
- 
- 
- 
44% 

0% 
-4% 

- 
- 
- 
- 
- 
- 
25% 

0% 
4% 

- 
- 
- 
- 
- 
- 
11% 

20 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Directors’ Remuneration Compared to Other Employees (continued) 

The table below shows the percentage change in remuneration of each director and the parent company’s non-executive 
directors on a full-time equivalent basis between the year ended 31 December 2019 and the year ended 31 December 2020. 

Executive Director 

Ray Prudo, M.D. 
Clive Richardson 
Non-Executive Director 
James Hill, M.D. 
Stuart Ungar, M.D. 
David Byrne 
Donald Williams 
Peter Feldschreiber 
Michael Grissinger 
Other Employees 

Change in Remuneration in year ended 31 December 2019 compared with 
remuneration in the year ended 31 December 2020 

Salary and/or Fees 

Taxable Benefits 

Annual Bonus 

3% 
17% 

- 
- 
- 
- 
- 
- 
23% 

- 
19% 

- 
- 
- 
- 
- 
- 
-9% 

3% 
21% 

- 
- 
- 
- 
- 
- 
8% 

Relative Importance of Cash Position 

The following table sets forth the cash amounts as at 31 December 2023 and 31 December 2022.  

Period 

Cash 

31 December 2023 
($) 
3,845,000 

31 December 2022 
($) 
13,250,000 

Change  
(%) 
(71%) 

Implementation of remuneration policy for year ending 31 December 2023 

Our director remuneration, comprised of annual cash retainers and equity grants, is administered by our board of directors 
with the assistance of the compensation committee. The compensation committee conducts an annual review of director 
remuneration and makes recommendations to the board with respect thereto. 

The shareholders approved our Directors Remuneration Policy on June 30, 2023 to provide a framework for the Directors’ 
remuneration packages. In addition, the Company has a non-executive director remuneration policy, which was amended 
and restated on November 19, 2015, and was subsequently amended on June 29, 2016, January 26, 2017, January 23, 2018, 
January 8, 2019, and on January 9, 2020. On February 1, 2023, our board resolved that the annual cash retainers would be 
increased by 5%, as compared to 2022. As a result, our non-executive directors were compensated for service on our board 
of directors as follows in 2023: 

an annual retainer for service on the board of directors of $41,305; 

an  annual  retainer  for  service  as  a  member  of  the  compensation  committee  and  nominating  and 
governance committee of $5,570; 

an annual retainer for service as a member of the audit committee of $7,875; 

for the chairman of the compensation committee, and nominating and governance committee, an annual 
retainer of $11,139; 

for the chairperson of the audit committee, an annual retainer of $18,375; 

21 

 
 
 
 
 
 
 
 
 
 
 
 
  
 
  
  
 
  
  
 
  
   
 
  
  
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

The following table presents the increases in compensation (board fees and/or salaries) agreed for the upcoming fiscal year 
(with the agreed increases for the year ended 31 December 2023 presented as comparative information): 

31 December 
2022 

31 December 
2023 

Increase/ 
(Decrease) 
%(1) 

31 December 
2023 

31 December 
2024(2) 

Increase/ 
(Decrease) 
%(3) 

$412,000 

$100,000 

(76%) 

$100,000 

$100,000 

0% 

$118,195 

- 

N/A 

N/A 

N/A 

N/A 

$458,333 

$615,750 

34% 

$615,750 

$615,750 

0% 

Director 

Executive Director 

Ray Prudo, 
M.D. (4) 

Clive 
Richardson(5)  

Rachelle 
Jacques(6) 

Non-Executive Director 

Michael 
Grissinger 

Samir R. Patel, 
M.D(7) 

Mohamed Wa’el 
Ahmed Hashad 

Donald 
Williams 

$49,947 

$60,350 

21% 

$60,350 

$65,889 

9% 

- 

- 

$3,704 

N/A 

$3,704 

$46,875(8) 

1,166% 

$28,684 

N/A 

$28,684 

$57,055 

99% 

$56,838 

$65,280 

15% 

$65,280 

$70,819 

85% 

James Hill  

$61,502 

$29,343 

Stuart Ungar 

$49,064 

$23,645 

David Byrne 

$58,332 

$49,170 

Peter 
Feldschreiber 

$24,974 

- 

(52%) 

(52%) 

(16%) 

N/A 

$29,343 

$23,645 

$49,170 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

N/A 

(1)  On February 1, 2023, the Compensation Committee approved a 5% annual retainer increase for our non-executive directors, effective as of January 
1, 2023. All directors are eligible to receive reimbursement for reasonable out-of-pocket expenses incurred in connection with attendance at meetings 
of our board of directors, and our non-executive directors are also eligible to receive reimbursement, upon approval of the board of directors or a 
committee  thereof,  for  reasonable  out-of-pocket  expenses  incurred  in  connection  with  attendance  at  various  conferences  or  meetings  with  our 
management.  

(2)  All figures are estimates. Additional discretionary bonuses may be awarded in accordance with contractual entitlement and the remuneration policy. 

(3)  There were no changes to annual retainers for our executive and non-executive directors in 2024. Changes represent the timing of appointment or 

termination of service on our board, or sub-committee thereof. 

(4)  Dr. Prudo served as our executive chairman from September 2015 through December 2022. Effective January 1, 2023, Dr. Prudo began serving as 

the Chairman of our board of directors with a renumeration package of $100,000 per annum, paid in equal monthly installments. 

(5)  Mr. Richardson resigned as Chief Executive Officer and Chief Operating Officer in March 2022. His annual base compensation of £382,306 was 

pro-rated during 2022.  

(6)  Ms. Jacques was appointed as our Chief Executive Officer in March 2022. Her annual base compensation of $458,333 for this role was pro-rated 

during 2022. Ms. Jacques received an annual base salary of $615,750 until her departure, effective May 1, 2024.  

(7)  All figures represent annual board and committee retainers. Dr. Patel was appointed as a non-executive director on 29 November 2023 and 

eligible for compensation in accordance with our non-executive director remuneration policy. Dr. Patel will also be compensated for his services 
as Interim President and Chief Executive Officer monthly in the form of restricted stock units (“RSUs”) with a fair market value of $50,000. 

22 

 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Compensation Committee Approach to Remuneration Matters 

Our board of directors and compensation committee review compensation annually for our executives. In setting executive 
base salaries and bonuses and granting equity incentive awards, we consider compensation for comparable positions in the 
market,  the  historical  compensation  of  our  executives,  individual  performance  as  compared  to  our  expectations  and 
objectives, our desire to motivate our employees to achieve short- and long-term results that are in the best interests of our 
shareholders, and a long-term commitment to our Company. 

Our compensation committee is primarily responsible for determining the compensation for our executive officers. Our 
compensation committee typically reviews and discusses management’s proposed compensation with our Chief Executive 
Officer for all executives other than the Chief Executive Officer. Based on those discussions and its discretion, taking into 
account the factors noted above, the compensation committee then sets the compensation for each executive officer other 
than  the  Chief  Executive  Officer  and  recommends  the  compensation  for  the  Chief  Executive  Officer  to  our  board  of 
directors for approval. Our board of directors discusses the compensation committee’s recommendation and ultimately 
approves the compensation of our Chief Executive Officer without members of management present. 

In  2023,  our  compensation  committee  utilized  the  services  of  Amplify  Strategy  &  Consulting  LLC  (“Amplify”),  an 
independent compensation consultant. During 2023, Amplify did not provide material services to us other than the services 
to our compensation committee. Based on its evaluation, our compensation committee has determined that Amplify’s work 
has not raised any conflict of interests. 

23 

 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

PART II - DIRECTORS’ REMUNERATION POLICY 

This  section  provides  information  about  the  Directors’  Remuneration  Policy  (the  “Policy”)  of  Akari.  The  Policy  was 
approved at the 2023 Annual General Meeting of Shareholders (“AGM”) and will remain in effect for a period of three 
years thereafter, unless changes to the Policy are required earlier and a new Policy is put to shareholder vote.   

The Policy seeks to provide compensation packages which will attract, motivate, reward and retain an executive team with 
the right caliber of talent, experience, and skills to lead a successful future for Akari. Akari’s compensation framework is 
designed to provide a competitive package in comparison to companies of similar size, complexity, maturity profile and 
geographic presence. Elements of compensation packages which are subject to performance conditions as noted in the 
Policy may include key performance indicators (KPIs), both financial and non-financial, which are an important component 
of the information needed to explain a company’s progress towards its stated goals.  Other elements which are not subject 
to  performance  measures  are  considered  an  important  component  of  attracting  and  retaining  UK  resident  employees, 
including Executive Directors. 

The table below sets out the main elements of the Policy for its Executive Directors and seeks to explain how each element 
of the compensation package operates: 

Policy Table – Executive Directors 

Element 

Purpose and 
Link to Strategy 

Operation 

Maximum Opportunity 

Performance Metrics 
and Recovery Provisions 

Support the 
recruitment and 
retention of 
Executive 
Officers 

Base Salary 

Encourages and 
enables 
executives to 
build savings for 
their retirement 

Pension and 
other 
retirement 
plans 

•  Base salary levels 
are set taking into 
account the role, 
responsibilities 
and individual’s 
experience in the 
position, 
performance of 
the individual and 
Akari.  Market 
competitiveness 
within the 
Company’s peer 
benchmarks are 
utilized to “price” 
a job. 

•  Base salaries are 

typically 
reviewed 
annually. 

•  Akari typically 

makes 
contributions to 
pension plans (or 
retirement 
savings plans) to 
match prevailing 
local market 
practices. 

24 

•  There is no 

•  None, although 

overall performance 
of the individual is 
considered when 
setting and reviewing 
salaries. 

•  No provisions for 
recovery or 
withholding of sums 
as this is not 
performance-related. 

prescribed maximum 
increase nor any 
requirement to 
increase salary at any 
time.  The Company 
uses established 
salary ranges for 
annual merit 
increases 

•  By exception, higher 
increases may be 
made to reflect 
individual 
circumstances.  
These may include 
significant changes in 
the job size or 
complexity and/or 
promotion. 

•  Currently up to 10% 
of salary per annum. 

•  None. 

•  No provisions for 
recovery or 
withholding of sums 
as this is not 
performance-related. 

 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Element 

Purpose and 
Link to Strategy 

Operation 

Maximum Opportunity 

Performance Metrics 
and Recovery Provisions 

Other 
Benefits 

Bonus 

Provide market 
competitive 
benefits in a cost-
effective way 

•  Provisions 

•  No prescribed 

•  None. 

maximum.  The cost 
of benefits will vary 
from year to year in 
accordance with the 
cost of insuring such 
benefits. 

•  No provisions for 
recovery or 
withholding of sums 
as this is not 
performance-related. 

• 

include medical 
insurance, life 
assurance, 
permanent health 
insurance, etc. 

In exceptional 
circumstances, 
such as the 
relocation of an 
executive or for a 
new hire, 
additional 
benefits may be 
provided in the 
form of relocation 
allowance and 
benefits. 

•  Other benefits 

may be offered if 
considered 
appropriate and 
reasonable by the 
Compensation 
Committee. 

To reward the 
delivery of annual 
targets as well as 
to recognise  
individual 
contributions 
towards our key 
strategic 
achievements 

•  Any bonus is paid 

•  The maximum 

annual bonus payable 
for any financial year 
is 100% of target 
bonus, although the 
Compensation 
Committee reserves 
the right to vary this 
amount in 
exceptional 
circumstances and 
based on assessment 
of Company and 
individual 
performance and 
goals achievement. 

in cash typically 
within 60 days 
after the end of 
the financial year 
to which it 
relates. 

•  Performance 

objectives and 
targets are either 
fixed 
contractually or 
set annually and 
actual payout 
levels are 
determined after 
the year end, 
based on 
performance 
against targets 
subject to 
overriding 
discretion of the 

25 

•  Where performance 
conditions are 
attached to a bonus 
payment, targets are 
either fixed 
contractually or 
selected by the 
Compensation 
Committee and set 
annually and can 
include key financial, 
operational and/or 
individual objectives. 

•  All assessments of 

performance against 
target is made by the 
Compensation 
Committee in its sole 
discretion. 

•  No provisions for 
recovery or 
withholding of sums 
as the performance 

 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Element 

Purpose and 
Link to Strategy 

Operation 

Maximum Opportunity 

•  There is no specific 
maximum set for 
annual equity awards. 

•  When making 
awards, the 
Compensation 
Committee will take 
into account internal 
grant guidelines, 
which have been set 
in reference to local 
market norms. 

Performance Metrics 
and Recovery Provisions 

measures are 
considered adequate. 

•  Where performance 
conditions are 
attached to an award, 
these typically include 
key financial, 
operational and/or 
individual objectives 
subject to overall 
Compensation 
Committee discretion. 

•  No provisions for 
recovery or 
withholding of sums as 
the performance 
measures are 
considered adequate. 

•  Grant value of 

•  None. 

£30,000 or local 
market rules as 
amended from time 
to time. 

•  No provisions for 
recovery or 
withholding of sums 
as this is not 
performance-related. 

To motivate and 
reward long-term 
performance in 
alignment with 
the shareholder 
interests and 
value- creation 

Equity 
Incentive 
Plan (2014 
Equity 
Incentive 
Plan & 2023 
Equity 
Incentive 
Plan ) 

CSOP (UK 
resident 
employees 
and directors 
only) 

Compensation 
Committee. 

•  Awards may be 

made periodically 
to Executive 
Officers in the 
form of options 
or in shares 
including stock 
appreciation 
rights, phantom 
stock awards or 
restricted stock 
units. 

•  Awards typically 
vest over two or 
four years and 
may be subject to 
incremental 
vesting. 

•  Executives are 
eligible to 
participate in the 
all- employee 
CSOP Plan under 
the same 
conditions as all 
other employees. 

26 

 
 
 
 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Policy Table – Non-Executive Directors 

Akari’s non-executive compensation policy is administered by its Board of Directors (the “Board”) with the assistance of 
the Compensation Committee. The Compensation committee periodically reviews the non-executive director compensation 
policy and makes recommendations to the Board. 

Non-Executive Directors typically receive an annual retainer paid in cash for their service (depending on their additional 
membership and chairman responsibilities) and an annual grant of stock options but do not participate in the bonus plan to 
which Executive Officers are eligible, nor do they typically receive any other performance related payment.  There are no 
elements  of  the  non-executive  director  compensation  policy  which  are  subject  to  performance  conditions  given  the 
necessity to maintain directors’ independence and board effectiveness in corporate governance, and accordingly there are 
no provisions for recovery or withholding of sums. 

The table below sets out some of the features of Akari’s current non-employee director compensation policy: 

Element 

Purpose and 
Link to Strategy 

Operation 

Maximum Opportunity 

Performance Metrics 

•  None. 

•  There is no prescribed 
maximum increase nor 
any requirement to 
increase salary at any 
time. 

Support the 
recruitment and 
retention of Non- 
Executive 
Directors 

Annual 
Cash 
Retainer 
Fee 

•  Each Non-
Executive 
Director serving 
on the Board 
receives an 
annual cash 
retainer, with 
additional 
amounts payable 
for acting as a 
chairman or a 
member of 
various 
committees. 

• 

In addition, the 
Chairman 
receive an 
additional cash 
retainer. 

•  Annual cash 
retainers are 
typically payable 
on a quarterly 
basis with the 
exception of the 
Executive 
Chairman who is 
paid monthly. 

•  A Non-Executive 
Director may 
elect to receive 
annual cash 
payments in the 
form of fully- 

27 

 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Element 

Purpose and 
Link to Strategy 

Operation 

Maximum Opportunity 

Performance Metrics 

•  None. 

•  Normal initial grant 
and annual grant of 
share options will be 
equal to 5,000,000 (or 
equivalent value of 
ADS) but the 
Committee reserves 
the discretion to 
review and amend this 
amount. 

Strengthens the 
alignment to 
shareholders’ 
interests through 
share ownership 

Share 
Options 

vested ordinary 
shares. 

•  Directors 

typically receive 
an annual grant 
of options in the 
form of market 
value options 
under the 
Company’s 
Equity Incentive 
Plan then in 
effect. 

•  These awards 

typically vest in 
full on the date 
of the next AGM 
following the 
date of grant, 
subject to the 
Non-Executive 
Director’s 
continued service 
on the Board, 
have a term of 
10 years from 
date of grant, and 
vesting 
accelerates in the 
case of a change 
of control. 

The foregoing is qualified in its entirety by Akari’s current non-executive director compensation policy, as may be amended 
from time to time 

Approach to Recruitment Compensation  

Akari’s policy is to pay a fair remuneration package for the role being undertaken and the experience of the individual to 
be appointed. Akari expects remuneration packages for Executive Directors to include base salary, targeted level of annual 
cash incentive, initial and ongoing equity-based awards, standard benefits and special provisions tailored to the recruiting 
situation, such as: sign-on bonus, reasonable relocation support and make-whole awards for remuneration forfeited from a 
prior  employer  (whether  on  account  of  cash  bonuses,  share  awards,  pension  benefits  or  other  forfeited  items).    The 
Compensation  Committee  retains  the  discretion  to  provide  additional  cash,  share  based  payment,  benefits  and  other 
remuneration where necessary or useful to recruit new Executive Directors or to secure the ongoing service of existing 
Executive Directors. The remuneration package for any new non-Executive Director will be set in accordance with the 
terms of Akari’s nonemployee director compensation policy then in effect.  Akari expects remuneration packages for non-
Executive Directors to include an annual retainer paid in cash for their service (depending on their additional membership 
and chairman responsibilities) and an annual grant of stock options.  Non-Executive Directors do not participate in the 
bonus plan to which Executive Officers are eligible, nor do they typically receive any other performance related payment. 

28 

 
 
 
AKARI THERAPEUTICS, PLC  

DIRECTORS’ REMUNERATION REPORT (continued) 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Director’s Service Contracts 

Akari’s board of directors is divided into three classes for purposes of election (Class A Directors, who serve a one year 
term before being subject to re-election at Akari’s annual general meeting; Class B Directors, who serve a two year term 
before being subject to re-election at the annual general meeting; and Class C Directors who serve a three year term before 
being subject to re-election at the annual general meeting, provided also that in any two year period, a majority of the board 
must stand for re-election). 

It is the Company’s policy that executive Directors should have contracts with an indefinite term.  Directors’ notice periods 
are set by the compensation committee, having regard to the need to attract and retain talent, ensure an orderly succession 
and  enable  the  company  to  manage  its  personnel  while  avoiding  excessive  costs.  Service  contracts  are  available  for 
inspection at Akari’s registered office or 75/76 Wimpole Street London W1G 9RT. 

Policy on Payments for Loss of Office 

Akari’s  approach  to  payments  to  Executive  Directors  in  the  event  of  termination  is  to  take  account  of  the  individual 
circumstances including the reason for termination, individual performance, contractual obligations and the terms of any 
option award. 

Generally, Akari employment arrangements for Executive Directors include a notice provision and continuing payment 
obligations  as  per  the  individual  Executive  Director  service  contracts  following  termination  by  Akari  of  an  Executive 
Director without cause or termination by the Executive Director for good reason or change of control.  Payment obligations, 
if any, include base salary, benefits, and all or some portion of target annual cash remuneration.  Akari may offer payment 
in lieu of notice if it is considered to be in the best interests of Akari. 

Treatment  of  unvested  outstanding  equity  awards  will  be  determined  according  to  the  specific  nature  of  termination, 
individual contracts, and plan rules. 

The  Compensation  Committee  reserves  the  right  to  make  payments  it  considers  reasonable  under  a  compromise  or 
settlement agreement, including payment or reimbursement of reasonable legal and professional fees, and any payment or 
compensation (in whatever form) in respect of statutory rights under employment law in the US, UK or other jurisdictions.  
Payment or reimbursement (in whatever forms) of reasonable outplacement fees may also be provided. 

Other Relevant Information Considered 

As appropriate, the Compensation Committee considers the pay and conditions of the broader employee workforce, as well 
as the Consumer Price Index and Retail Price Index, when making compensation related decisions for the directors.  The 
Compensation Committee does not consult employees, other than Executive Directors, when drafting the Policy. 

The Compensation Committee also considers shareholder feedback, so far as it relates to compensation, when reviewing 
the appropriateness of the Policy.  In addition, the Compensation Committee considers potential conflicts of interest and 
directors do not have sole discretion over their own remuneration. 

This report was approved by the Board on 3 June 2024 and signed on its behalf. 

Samir R. Patel 

Samir R. Patel, M.D.  
Director and Interim Chief Executive Officer 

29 

 
 
 
 
 
 
 
 
 
 
 
INDEPENDENT AUDITOR’S REPORT TO THE SHAREHOLDERS OF 

AKARI THERAPEUTICS PLC  

FOR THE YEAR ENDED 31 DECEMBER 2023 

Opinion  
We have audited the financial statements of Akari Therapeutics, Plc (the ‘parent company’) and its subsidiaries (the 
‘group’) for the year ended 31 December 2023 which comprise the consolidated statement of comprehensive loss, the 
consolidated  statement  of  financial  position,  the  parent  company  statement  of  financial  position,  the  consolidated 
statement of changing in equity, the parent company statement of changes in equity, the consolidated statement of 
cash flows, the parent company statement of cash flows and notes to the financial statements, including a summary of 
significant  accounting  policies.  The  financial  reporting  framework  that  has  been  applied  in  their  preparation  is 
applicable law and UK adopted international accounting standards.  

In our opinion, the financial statements:  

• give a true and fair view of the state of the group’s and of the parent company’s affairs as at 31 December 2023 and of 

the group’s loss for the year then ended;  

• have been properly prepared in accordance with UK adopted international accounting standards; and  
• have been prepared in accordance with the requirements of the Companies Act 2006.  

Basis for opinion  
We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable 
law. Our responsibilities under those standards are further described in the Auditor’s responsibilities for the audit of 
the  financial  statements  section  of  our  report.  We  are  independent  of  the  group  in  accordance  with  the  ethical 
requirements that are relevant to our audit of the financial statements in the UK, including the FRC’s Ethical Standard 
as  applied  to  listed  entities,  and  we  have  fulfilled  our  other  ethical  responsibilities  in  accordance  with  these 
requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for 
our opinion.  

An overview of the scope of our audit  
As  part  of  designing  our  audit,  we  determined  materiality  and  assessed  the  risks  of  material  misstatement  in  the 
financial statements. In particular, we considered areas where subjective judgement was exercised by the directors and 
management,  for  example  in  respect  of  significant  accounting  estimates  that  involved  making  assumptions  and 
considering future events that are inherently uncertain. We also assessed the risk of management override of controls, 
including  evaluating  whether  there  was  evidence  of  bias  by  the  directors  that  represented  a  risk  of  material 
misstatement due to fraud. We tailored the scope of our audit to ensure that we performed sufficient work to be able 
to give an opinion on the financial statements as a whole, taking into account the structure of the group and the parent 
company, the accounting processes and controls, and the industry in which they operate.   

Our audit scope included the statutory audit of the parent company for the year ended 31 December 2023. It excludes 
the parent company’s non-UK registered subsidiaries which were audited to component materiality for the purposes 
of the group audit.  

Key audit matters  
Key audit matters are those matters that, in our professional judgment, were of most significance in our audit  of the 
financial  statements  of  the  current period  and  include  the  most  significant  assessed  risks  of  material  misstatement 
(whether or not due to fraud) we identified, including those which had the greatest effect on: the overall audit strategy, 
the allocation of resources in the audit; and directing the efforts of the engagement team. These matters were addressed 
in the context of our audit of the financial statements as a whole, and in forming our opinion thereon, and we do not 
provide a separate opinion on these matters.  

30 

 
 
  
  
  
  
  
  
  
 
 
 
 
 
 
 
 
 
 
 
INDEPENDENT AUDITOR’S REPORT TO THE SHAREHOLDERS OF 

AKARI THERAPEUTICS PLC  

FOR THE YEAR ENDED 31 DECEMBER 2023

 Key Audit Matter  
Valuation of Parent Company investment 
in subsidiaries and amounts due from 
group undertakings 

How our scope addressed this matter  

Our audit work included, but was not restricted to, the 
following:  

•  Review of management’s impairment assessment in 

The Parent Company recognises investments 
in subsidiaries with a carrying value of 
$18,339k. The Group has yet to record 
revenue or recognise an intangible asset in 
association with research and development 
costs. During the year, there was a material 
decline in the market capitalisation of the 
Group which under IAS 36 is considered an 
example of a significant impairment 
indicator. During the year, the Parent 
Company recognised impairment charges of 
$5,758k against investments in subsidiaries 
and amounts owed from group undertakings. 

There is risk these assets may be materially 
overstated. 

relation to Parent Company investments in 
subsidiaries and amounts due from group 
undertakings. 

•  Consideration of management’s assessment of the 
fair value of the equity of subsidiary undertakings, 
which was made with reference to appraisal of what 
the implied enterprise value of the Group is 
attributable to, and valuation reports prepared for the 
Group. 

•  Consideration of contradictory evidence suggesting 

that carrying values associated with these assets as at 
31 December 2023 may be materially overstated. 
•  Review of disclosures made in respect of these assets 

to ensure adequate information is provided to 
highlight the basis on which accounting estimates 
have been made and the degree of uncertainty 
associated with them. 

Our application of materiality  
We  apply  the  concept  of  materiality  both  in  planning  and  performing  our  audit,  and  in  evaluating  the  effect  of 
misstatements on our audit and on the financial statements. For the purposes of determining whether the financial 
statements are free from material misstatement we define materiality as the magnitude of misstatement that makes it 
probable that the economic decisions of a reasonably knowledgeable person, relying on the financial statements, would 
be changed or influenced. We determined overall materiality for the Group and Parent Company financial statements 
as  a  whole  to  be  US$350,000  being  1.7%  of  R&D  and  administrative  expenditure  for  the  year.  We  considered  it 
appropriate to determine our materiality based on expenditure as we consider this to be the key metric in assessing the 
financial performance and position of the Group given its primary purpose is to undertake research and development 
activities. On the basis of our risk assessments, together with our assessment of the overall control environment, we 
apply a different level of materiality, performance materiality, to determine the extent of our testing and this was set 
at 75% of the overall audit financial statements’ materiality, being $263,000. 

We agreed with management that we would report to the Audit Committee all audit differences in excess of US$17,500 
as well as differences below that threshold that, in our view, warranted reporting on qualitative grounds. We also report 
to the Audit Committee on disclosure matters that we identified when assessing the overall presentation of the financial 
statements.  

Material uncertainty in relation to going concern  
We draw attention to note 1(c) in the financial statements, which outlines considerations relating to the group’s and 
parent company’s ability to continue as a going concern. The disclosure indicates that the group and parent company 
are reliant on additional funding, which is largely contingent on the completion of a proposed merger transaction, to 
meet their liabilities as they fall due, together with management of liquidity and working capital positions prior this. 
These circumstances indicate the existence of a material uncertainty which may cast significant doubt on the group’s 
ability to continue as a going concern. Our opinion is not modified in respect of this matter.  

In auditing the financial statements, we have concluded that the directors’ use of the going concern basis of accounting 
in the preparation of the financial statements is appropriate. They have concluded that there is a material uncertainty 
which could cast significant doubt over the going concern status of the Group due to the impact of the requirement for 
additional  fundraising,  and  we  agree  that  this  is  adequately  disclosed  in  the  Directors’  Report  and  the  accounting 
policies.  

The key risk identified was uncertainty around the ability of the Group and Parent Company to raise funds in order to 
continue operations. While the Group and Parent Company have a history of raising funds as required, past history is 
no guarantee that further fundraising which is mostly dependent on the merger going ahead, will be successful.  Future 
fundraising could be delayed and the amounts arising from future fundraises are uncertain. A significant delay in the 

31 

 
 
 
 
  
  
  
INDEPENDENT AUDITOR’S REPORT TO THE SHAREHOLDERS OF 

AKARI THERAPEUTICS PLC  

FOR THE YEAR ENDED 31 DECEMBER 2023

ability to raise funds would negatively impact the group’s ability to generate cash to meet its liabilities as and when 
they fall due.  

Our  evaluation  of  the  directors’  assessment  of  the  entity’s  ability  to  continue  to  adopt  the  going  concern  basis  of 
accounting included an assessment of the inherent risks to the Group’s business model and how such risks may impact 
the  ability  to  continue  operations  over  the  going  concern  assessment  period.  We  also  undertook  the  following 
procedures:  

-  We reviewed trading and fundraising activities after the reporting date and considered management’s assessment 

of the Group’s and Parent Company’s prospects regarding further fundraising.  

-  We reviewed cash flow forecasts prepared by management and assessed their adequacy, and also challenged the 

assumptions and judgements inherent within them.  

-  We assessed the Group’s and Parent Company’s financial position (including cash) as at the date of approval of 

the financial statements. 

-  We considered for reasonableness management’s commentary around the Group’s management of its working 
capital  positions,  including  accounts  receivable  and  payable,  and  its  implications  for  cash  availability  and  the 
quantum and timing of anticipated fundraising.  

Our responsibilities and the responsibilities of the directors with respect to going concern are described in the relevant 
sections of this report.    

Other information  
The directors are responsible for the other information. The other information comprises the information included in 
the annual report, other than the financial statements and our auditor’s report thereon. Our opinion on the financial 
statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we 
do not express any form of assurance conclusion thereon.   

In connection with our audit of the financial statements, our responsibility is to read the other information and, in 
doing  so,  consider  whether  the  other  information  is  materially  inconsistent  with  the  financial  statements  or  our 
knowledge  obtained  in  the  audit  or  otherwise  appears  to  be  materially  misstated.  If  we  identify  such  material 
inconsistencies  or  apparent  material  misstatements,  we  are  required  to  determine  whether  there  is  a  material 
misstatement in the financial statements or a material misstatement of the other information. If, based on the work we 
have performed, we conclude that there is a material misstatement of this other information, we are required to report 
that fact. We have nothing to report in this regard.  

Opinions on other matters prescribed by the Companies Act 2006  
In our opinion, based on the work undertaken in the course of the audit:  
• the  information  given  in  the  strategic  report  and  the  directors’  report  for  the  financial  year  for  which  the  financial 

statements are prepared is consistent with the financial statements; and  

• the strategic report and the directors’ report have been prepared in accordance with applicable legal requirements.  

Matters on which we are required to report by exception  
In the light of the knowledge and understanding of the group and the parent company and its environment obtained in the 
course of the audit, we have not identified material misstatements in the strategic report or the directors’ report.  

We have nothing to report in respect of the following matters in relation to which the Companies Act 
2006 requires us to report to you if, in our opinion:  
• adequate accounting records have not been kept by the parent company, or returns adequate for our audit have not been 

received from branches not visited by us; or  

• the parent company financial statements are not in agreement with the accounting records and returns; or  
• certain disclosures of directors’ remuneration specified by law are not made; or  
• we have not received all the information and explanations we require for our audit.  

Responsibilities of directors  
As explained more fully in the directors’ responsibilities statement set out on page 5, the directors are responsible for 
the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such 

32 

 
 
 
  
  
  
  
  
INDEPENDENT AUDITOR’S REPORT TO THE SHAREHOLDERS OF 

AKARI THERAPEUTICS PLC  

FOR THE YEAR ENDED 31 DECEMBER 2023

internal control as the directors determine is necessary to enable the preparation of financial statements that are free 
from material misstatement, whether due to fraud or error.  

In preparing the financial statements, the directors are responsible for assessing the group’s and the parent company’s 
ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going 
concern basis of accounting unless the directors either intend to liquidate the group or the parent company or to cease 
operations, or have no realistic alternative but to do so.  

Auditor’s responsibilities for the audit of the financial statements  
Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free  from 
material  misstatement,  whether  due  to  fraud  or  error,  and  to  issue  an  auditor’s  report  that  includes  our  opinion. 
Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with 
ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and 
are  considered  material  if,  individually  or  in  the  aggregate,  they  could  reasonably  be  expected  to  influence  the 
economic decisions of users taken on the basis of these financial statements.  

Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in 
line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including 
fraud. The extent to which our procedures are capable of detecting irregularities, including fraud is detailed below:   

Explanation as to what extent the audit was considered capable of detecting irregularities, including fraud   
Based on our understanding of the company and industry, we identified that the principal risks of non-compliance with 
laws  and  regulations  related  to  regulatory  requirements  for  the  company.  We  considered  the  extent  to  which 
noncompliance might have a material effect on the financial statements. We also considered those laws and regulations 
that have a direct impact on the preparation of the financial statements such as the Companies Act 2006, income tax 
and payroll taxes.  

We  evaluated  management’s  incentives  and  opportunities  for  fraudulent  manipulation  of  the  financial  statements 
(including the risk of override of controls), and determined that the principal risks were related to posting inappropriate 
journal entries to areas subject to significant judgement and management bias through accounting estimates. Audit 
procedures performed by the engagement team included:  

Inspecting filings with regulators;  

- 
-  Discussions with management including consideration of known or suspected instances of non-compliance with 

laws and regulation and fraud;  

-  Evaluating management’s controls designed to prevent and detect irregularities;  
- 

Identifying and testing journals, in particular journal entries posted with key words, by individuals who do not 
usually make journals, posted around the end of the period, posted with certain keywords, and journals posted at 
unusual dates or times, and;  

-  Challenging assumptions and judgements made by management in their critical accounting estimates.  

Because of the inherent limitations of an audit, there is a risk that we will not detect all irregularities, including those 
leading to a material misstatement in the financial statements or non-compliance with regulation. This risk increases 
the more that compliance with a law or regulation is removed from the events and transactions reflected in the financial 
statements, as we will be less likely to become aware of instances of non-compliance. The risk is also greater regarding 
irregularities occurring due to fraud rather than error, as fraud involves intentional concealment, forgery, collusion, 
omission or misrepresentation.  

A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting 
Council’s website at: www.frc.org.uk/auditorsresponsibilities. This description forms part of our auditor’s report.  

33 

 
 
  
  
  
  
  
  
  
  
 
 
INDEPENDENT AUDITOR’S REPORT TO THE SHAREHOLDERS OF 

AKARI THERAPEUTICS PLC  

FOR THE YEAR ENDED 31 DECEMBER 2023

Use of our report  
This report is made solely to the company's members, as a body, in accordance with Chapter 3 of Part 16 of the 
Companies Act 2006. Our audit work has been undertaken so that we might state to the company's members those 
matters we are required to state to them in an Auditor's report and for no other purpose. To the fullest extent permitted by 
law, we do not accept or assume responsibility to anyone other than the company and the company's members as a body, 
for our audit work, for this report, or for the opinions we have formed.  

Christopher Cork (Senior Statutory Auditor)  
For and on behalf of Haysmacintyre LLP, Statutory Auditors   

4 June 2024 

10 Queen Street Place  
London  
EC4R 1AG  

34 

 
 
  
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC 

CONSOLIDATED STATEMENT OF COMPREHENSIVE LOSS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Research and development expenses 
Administrative expenses 

Notes 

2023 
$000 

(9,083) 
(11,358) 

2022 
$000 

(10,816) 
(13,075) 

OPERATING LOSS 

3 

(20,441) 

(23,891) 

Excess of consideration over fair value  
Fair value movement on liability related to warrants  
Net finance income / (cost) 

LOSS BEFORE INCOME TAX 

Income tax credit 

LOSS FOR THE YEAR 

Other Comprehensive Loss: 
Currency translation differences  

15 
4 

5 

- 
6,599 
413 

(1,963) 
6,946 
(575) 

(13,429) 

(19,483) 

1,189 

2,472 

(12,240) 

(17,011) 

(269) 

(230) 

COMPREHENSIVE LOSS FOR THE YEAR 

(12,509) 

(17,241) 

Loss  per  share  attributable  to  the  ordinary  equity  holder  of  the 
parent: 
Basic and diluted (cents) 

7 

(0.00) 

(0.00) 

All losses are derived from continuing activities for the current and previous financial year.  

The Company has elected to take the exemption under section 408 of the Companies Act 2006 not to present the parent 
company income statement. Refer note 6 for the results of the parent company.  

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

35 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

COMPANY NUMBER: 05252842 

CONSOLIDATED STATEMENT OF FINANCIAL POSITION 

AS AT 31 DECEMBER 2023 

ASSETS 
Non-current assets 
Intangible assets 

Current assets 
Trade and other receivables 
Cash and cash equivalents 

TOTAL ASSETS 

EQUITY 
Share capital 
Share premium 
Capital redemption reserve 
Other reserves 
Merger reserve 
Share based payment reserve 
Reverse acquisition reserve 
Retained losses 
TOTAL EQUITY 

LIABILITIES 
Current liabilities 
Trade and other payables 
Warrant liability 
TOTAL LIABILITIES 

TOTAL EQUITY AND LIABILITIES 

Notes 

8 

11 

13 
14 
14 
14 
14 
16 
14 
14 

12 
15 

2023 
$000 

14 
14 

1,713 
3,845 
5,559 

5,572 

1,324 
144,797 
52,194 
(1,079) 
9,128 
19,187 
(20,983) 
(203,580) 
988 

3,331 
1,253 
4,584 

5,572 

2022 
$000 

17 
17 

2,951 
13,250 
16,201 

16,218 

744 
138,269 
52,194 
(810) 
9,128 
18,037 
(20,983) 
(191,340) 
5,239 

3,127 
7,852 
10,979 

16,218 

The financial statements were approved and authorised for issue by the Board of Directors on 3 June 2024 and were signed 
below on its behalf by:               

Samir R. Patel 

Samir R. Patel, M.D. 
Director and Interim Chief Executive Officer 

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

36 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC 

                                                      COMPANY NUMBER: 05252842 

PARENT COMPANY STATEMENT OF FINANCIAL POSITION 

AS AT 31 DECEMBER 2023 

ASSETS 
Non-current assets 
Investment in subsidiaries 

Current assets 
Trade and other receivables 
Cash and cash equivalents  

TOTAL ASSETS 

EQUITY 
Share capital 
Share premium 
Capital redemption reserve 
Merger reserve 
Share based payment reserve 
Retained losses  
TOTAL EQUITY  

LIABILITIES 
Current liabilities 
Trade and other payables 
Warrant liability  
TOTAL LIABILITIES 

TOTAL EQUITY AND LIABILITIES 

Notes 

10 

11 

13 
14 
14 
14 
16 
14 

12 
15 

2023 
$000 

18,339 
18,339 

1,726 
3,745 
5,471 

23,810 

1,324 
144,797 
52,194 
9,128 
19,187 
(207,126) 
19,504 

3,053 
1,253 
4,306 

23,810 

2022 
$000 

20,339 
20,339 

6,717 
13,217 
19,934 

40,273 

744 
138,269 
52,194 
9,128 
18,037 
(188,871) 
29,501 

2,920 
7,852 
10,772 

40,273 

As  permitted  by  Section  408  of  the  Companies  Act  2006,  the  income  statement  of  the  parent  Company  is  not 
presented as part of these financial statements. The parent Company’s loss for the financial year was  $18,255,410 
(2022: loss of $17,280,833 ).  

The financial statements were approved and authorised for issue by the Board of Directors on 3 June 2024 and were 
signed below on its behalf by:                      

Samir R. Patel 

Samir R. Patel, M.D. 
Director and Interim Chief Executive Officer 

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

37 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  
STATEMENT OF CHANGES IN EQUITY 
FOR THE YEAR ENDED 31 DECEMBER 2023 

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY 

At 1 January 2022 

Loss for the year 

Total comprehensive loss for the year  

Share based payments 

Shares issued, net of transaction cost 

Total transactions with owners 

At 31 December 2022 

Loss for the year 

Total comprehensive loss for the year 

Share based payments 

Shares issued, net of transaction cost 

Issue of shares for vendor services 

Proceeds from employee vesting of restricted shares 

Total transactions with owners 

Share 
premium 

Other 
reserves 

Merger 
reserve 

Share 
based 
payment 
reserve 

Reverse 
acquisition 
reserve 

Capital 
redemption 
reserve 

$000 

$000 

$000 

$000 

$000 

$000 

Share 
capital 

$000 

Retained  
losses 

$000 

Total 
equity 

$000 

476 

125,059 

(580) 

9,128 

17,302 

(20,983) 

52,194 

(174,329) 

8,267 

- 

- 

- 

- 

- 

- 

268 

268 

13,210 

13,210 

(230) 

(230) 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

735 

- 

735 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

(17,011) 

(17,241) 

(17,011) 

(17,241) 

- 

- 

- 

735 

13,478 

14,213 

744 

138,269 

(810) 

9,128 

18,037 

(20,983) 

52,194 

(191,340) 

5,239 

- 

- 

- 

- 

- 

- 

568 

6,394 

8 

4 

134 

- 

580 

6,528 

(269) 

(269) 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

1,150 

- 

- 

- 

1,150 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

- 

(12,240) 

(12,509) 

(12,240) 

(12,509) 

- 

- 

- 

- 

- 

1,150 

6,962 

142 

4 

8,258 

At 31 December 2023 

1,324 

144,797 

(1,079) 

9,128 

19,187 

(20,983) 

52,194 

(203,580) 

988 

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

38 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  
STATEMENT OF CHANGES IN EQUITY 
FOR THE YEAR ENDED 31 DECEMBER 2023 

PARENT COMPANY STATEMENT OF CHANGES IN EQUITY 

At 1 January 2022 

Loss for the year 

Total comprehensive loss for the year 

Share based payments 

Shares Issued, net of transaction costs 

Total transactions with owners 

Share  
capital 

$000 

Share 
premium 

Merger 
reserve 

$000 

$000 

Share based 
payment 
reserve 
$000 

Capital 
redemption 
reserve 
$000 

Retained 
losses  

Total 
equity 

$000 

$000 

476 

125,059 

9,128 

17,302 

52,194 

(171,590) 

32,569 

- 

- 

- 

268 

268 

- 

- 

- 

13,210 

13,210 

- 

- 

- 

- 

- 

- 

- 

735 

- 

735 

- 

- 

- 

- 

- 

(17,281) 

(17,281) 

(17,281) 

(17,281) 

- 

- 

- 

735 

13,478 

14,213 

At 31 December 2022 

744 

138,269 

9,128 

18,037 

52,194 

(188,871) 

29,501 

Loss for the year 

Total comprehensive loss for the year 

Share based payments 

Shares issued, net of transaction costs 

Issue of shares for vendor services 

Proceeds from employee vesting of restricted shares 

Total transactions with owners 

- 

- 

- 

568 

8 

4 

580 

- 

- 

- 

6,394 

134 

- 

6,528 

- 

- 

- 

- 

- 

- 

- 

- 

- 

1,150 

- 

- 

- 

1,150 

- 

- 

- 

- 

- 

- 

- 

(18,255) 

(18,255) 

(18,255) 

(18,255) 

- 

- 

- 

- 

- 

1,150 

6,962 

142 

4 

8,258 

At 31 December 2023 

1,324 

144,797 

9,128 

19,187 

52,194 

(207,126) 

19,504 

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

39 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

CONSOLIDATED STATEMENT OF CASH FLOWS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Cash flows from operating activities 

Loss before income tax 

Adjustments for: 

Excess of consideration over fair value 

Changes in fair value of warrants 

Share-based payment 

Expenses settled in shares 

Foreign currency exchange (loss)/gains 

Amortization 

Decrease in trade and other receivables 

Increase /(decrease) in trade and other payables 

Tax received  

Net cash flows used in operating activities  

Cash flows from financing activities 

Proceeds from issuance of ordinary shares 

Issue costs 

Proceeds for future exercises of warrants to purchase shares  

Other 

Note 

2023 
$000 

2022 
$000 

(13,429) 

(19,483) 

15 

16 

13 

15 

- 

(6,599) 

1,150 

142 

(468) 

4 

124 

127 

2,571 

(16,378) 

7,972 

(1,010) 

- 

4 

1,963 

(6,946) 

735 

- 

142 

4 

1,699 

(1,936) 

2,318 

(21,504) 

26,942 

(1,748) 

94 

- 

Cash generated from financing activities 

6,966 

25,288 

Exchange losses on cash and cash equivalents 

Net (decrease)/increase in cash and cash equivalents 

Cash and cash equivalents at beginning of year 

Cash and cash equivalents at end of year 

7 

(9,405) 

13,250 

3,845 

105 

3,889 

9,361 

13,250 

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

40 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

PARENT COMPANY STATEMENT OF CASH FLOWS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

Cash flows from operating activities 

Loss before income tax 

Adjustments for: 

Excess of consideration over fair value 

Expenses settled in shares 

Changes in fair value of warrants 

Share based payments 

Impairment on investment 

Impairment on intercompany balance 

Decrease in trade and other receivables 

Increase / (decrease) in trade and other payables 

Taxation received  

Exchange rate differences 

Notes 

2023 
$000 

2022 
$000 

(19,444) 

(19,753) 

15 

16 

10 

- 

142 

(6,599) 

1,150 

2,000 

3,757 

48 

133 

2,571 

(214) 

1,963 

- 

(6,946) 

735 

- 

- 

1,782 

(1,966) 

2,318 

385 

Net cash flows used in operating activities  

(16,457) 

(21,482) 

Cash flows from investing activities 

Movement in intercompany 

Net cash generated by investing activities 

Cash flows from financing activities 

Proceeds from issuance of ordinary shares 

Issue costs 

Proceeds for future exercises of warrants to purchase shares 

Other 

18 

18 

7,972 

(1,010) 

- 

4 

- 

- 

26,942 

(1,748) 

94 

- 

13 

15 

Net cash generated from financing activities 

6,967 

25,288 

Exchange gains on cash and cash equivalents 

Net (decrease)/increase in cash and cash equivalents 

Cash and cash equivalents at beginning of year 

Cash and cash equivalents at end of year 

- 

(9,472) 

13,217 

3,745 

92 

3,898 

9,319 

13,217 

The notes on pages 42 to 63 form an integral part of the consolidated financial statements. 

41 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

1.  

GENERAL INFORMATION 

Akari Therapeutics, Plc is a public company limited by shares registered in England and Wales under number 5252482, with 
its registered office at Highdown House, Yeoman Way, Worthing, West Sussex, BN99 3HH. 

The principal accounting policies applied in the preparation of these consolidated financial statements are set out below. These 
policies have been consistently applied to all the years presented, unless otherwise stated. 

2.   

ACCOUNTING POLICIES 

Basis of preparation 

(a) 
These  consolidated  financial  statements  of  Akari  Therapeutics,  Plc  have  been  prepared  in  accordance  with  International 
Financial Reporting Standards (IFRS) as adopted by the UK and IFRIC interpretations issued and effective or issued and early 
adopted as at the time of preparing these statements and with those parts of the Companies Act 2006 applicable to companies 
reporting under IFRS.  

The consolidated and Company financial statements are presented in USD (“$”) the functional and presentations currency of 
the Company.  

The preparation of financial statements in conformity with IFRS requires the use of certain critical accounting estimates. It 
also requires management to exercise its judgement in the process of applying the Group’s accounting policies. The areas 
involving  a  higher  degree  of  judgement  or  complexity  or  areas  where  assumptions  and  estimates  are  significant  to  the 
consolidated financial statements are disclosed in note 1(n). 

Basis of consolidation 

(b) 
Subsidiaries are all entities over which the Group has control. The Group controls an entity when the Group is  exposed to, 
or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its 
power over the entity. The subsidiaries are fully consolidated from the date on which control is transferred to the Group 
and deconsolidated from the date that control ceases.  

The financial statements of the subsidiaries are prepared for the same financial year as the parent company,  applying 
consistent accounting policies throughout the Group. Inter-company balances and transactions, including unrealised profits 
are eliminated on consolidation. 

The Group financial statements consolidate the Company’s financial statements of Akari Therapeutics, Plc and its subsidiaries 
(the “Group”).  

Going Concern 

(c) 
The Group meets its day-to-day working capital requirements through funding. In assessing the Group’s ability to continue 
as a going concern, Management has prepared financial forecasts covering at least the next twelve months from the date of 
approval of the financial statements. 

The Group’s forecast and projections, show that at present, the Group has insufficient working capital to fulfil its current 
business plan without the Group raising additional capital. 

As of 31 December 2023, the Group’s cash balance was $3.8 million. To date, the Group has incurred substantial losses 
and negative cash flows since inception and had an accumulated deficit of $203.6 million as of 31 December 2023. 

The Group anticipates incurring additional losses until such time, if ever, that it can generate significant sales of its product 
candidates currently in development. The Group is subject to a number of risks and uncertainties similar to those of other 
companies of the same size within the biotechnology industry, such as uncertainty of clinical trial outcomes, uncertainty 
of additional funding, and history of operating losses. Substantial additional financing will be needed by the Group to fund 
its operations and to commercially develop its product candidates and there can be no assurance that additional funds will 
be available when the Group need them on terms that are acceptable to it, or at all. As of May 31, 2024, the Group’s cash 
balance of $5.9 million, which includes net proceeds received from the May 2024 Private Placement (see note 19 of the 
notes to financial statements), is not sufficient to fund its operations for the one-year period after the date these consolidated 
financial statements are issued.  

42 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

2.       ACCOUNTING POLICIES (continued) 

(c)       Going Concern (continued) 
Management  is  currently  evaluating  different  strategies  to  obtain  the  required  funding  for  future  operations.  These 
strategies may include, but are not limited to: product development financing, private placements and/or public offerings 
of  equity  and/or  debt  securities,  and  strategic  research  and  development  collaborations  and/or  similar  arrangements. 
Further, closing of the Group’s proposed merger with Peak Bio, Inc. as contemplated in the associated Merger Agreement 
is  contingent  on  the  PIPE  Investment  (as  defined  in  the  Merger  Agreement)  which  shall  have  been  consummated 
simultaneously with, and conditioned only upon, the occurrence of the closing, and shall result in net proceeds to the Group 
of least $10 million. Management also expects that further sources of funding will also be made available for the Group to 
draw on (if required) as a result of the merger. 

While management is confident in the Company’s ability to obtain future funding, there can be no assurance that these 
future funding efforts, including the PIPE Investment (as defined in the Merger Agreement), will be successful. 

Based on the requirement for Group to raise additional capital to finance future operations and for it to manage its working 
capital position, particularly in relation to accounts payable balances, until further such capital can be raised, management 
has concluded that these outcomes represent material uncertainties that cast significant doubt regarding the Group’s ability 
to continue as a going concern within one year after the date that these consolidated financial statements are issued. 

Notwithstanding these uncertainties, the accompanying consolidated financial statements have  been prepared assuming 
that we will continue as a going concern, which contemplates the realisation of assets and the satisfaction of liabilities in 
the normal course of business. As such, the accompanying consolidated financial statements do not reflect any adjustments 
relating to the recoverability and classification of recorded assets and liabilities that might be necessary if  the Group is 
unable to continue as a going concern. 

Standards and interpretations adopted during the year 

(d) 
The  accounting  policies  adopted  in  the  preparation  of  these  Consolidated  Financial  Statements  are  consistent  with  those 
followed in the preparation of the Group’s audited consolidated financial statements for the year ended 31 December 2023, 
which were prepared in accordance with the International Financial Reporting Standards (“IFRS”), as adopted by the United 
Kingdom, updated to adopt those standards which became effective for periods starting on or before 1 January 2022.  None 
of the new standards have had a material impact on the Group. 

Standards issued, but not yet effective 
The following standards are issued, but not yet effective. The Group intends to adopt these standards, if applicable, when they 
become effective. It is not expected that these standards will have a material impact on the Group. 

The Directors intends to adopt new and amended standards and interpretations, if applicable, when they become effective. At 
the date of approval of these financial statements, the following standards and interpretations which have not been applied in 
these financial statements were in issue for the period beginning 1 January 2024 but not yet effective:  

• 
• 
• 

IFRS 16 Leases (Amendment – Liability in a Sale and Leaseback) 
IAS 1 Presentation of Financial Statements (Amendment – Classification of Liabilities as Current or Non-current) 
IAS 1 Presentation of Financial Statements (Amendment – Non-current Liabilities with Covenants) 

The directors of the Company (the “Directors”) anticipate that the application of all new and amendments to IFRS will have 
no material impact on the future results of the Company in the foreseeable future.  

43 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

2.       ACCOUNTING POLICIES (continued) 

Foreign currency translation 

(e) 
Functional and presentation currency 
Items included in the financial statements of each of the Group’s entities are measured using the currency of the primary 
economic  environment  in  which  the  entity  operates  (the  “functional  currency”).  The  functional  currency  of  Akari 
Therapeutics, Plc is U.S. dollars.  The Group and Parent Company financial statements are presented in U.S Dollars which is 
considered to the Group’s presentation currency. 

Transactions and balances  
Foreign currency transactions are translated into the functional currency using the exchange rate prevailing at the date of the 
transactions or valuation where items are re-measured. Foreign exchange gains and losses resulting from the settlement of 
such transactions and from the translation at period-end exchange rates of monetary assets and liabilities denominated in 
foreign currencies are recognised in the income statement. 

Group companies 
The results and financial position of all the Group entities (none of which has the currency of a hyper-inflationary economy) 
that have a functional currency different from the presentation currency are translated as follows: 

a) 
b) 
c) 

assets and liabilities at the balance sheet date are translated at the closing rate as at that balance sheet date; 
income and expenses for each income statement are translated at average exchange rates; and 
all resulting exchange differences are recognised in other comprehensive income. 

(f) 
Cash and cash equivalents include cash in hand and deposits held at call with banks.  

Cash and cash equivalents 

Trade and other payables 

(g) 
Trade payables are obligations to pay for goods or services received that have been acquired in the ordinary course of the 
business from suppliers. Trade payables are classified as current liabilities if payment is due within one year or less. If not, 
they are presented as non-current liabilities.  Executory contracts are recognised when both parties to the contract met their 
respective obligations. Trade and other payable are unsecured, non-interest bearing and are stated at cost. 

Trade and other receivables 

(h) 
Trade and other receivables are recognised at fair value less a provision for impairment.  Bad debts are written off through the 
income statement when identified. If collection is expected in one year or less, they are classified as current assets. If not, they 
are presented as non-current assets.    

Financial liabilities 

(i) 
All financial liabilities are recognised in the statement of financial position when the Group becomes a party to the contractual 
provision of the instrument.  

Financial liabilities measured at amortised cost 
The Group’s financial liabilities measured at amortised cost comprise trade payables and other payables and bank and other 
borrowings. 

These financial liabilities are initially measured at fair value net of any transaction costs directly attributable to the issue of 
the instrument and are subsequently measured at amortised cost using the effective interest rate method. 

The effective interest method is a method of calculating the amortised cost of a financial liability and of allocating interest 
expense over the relevant period. The effective interest rate is the rate that exactly discounts estimated future cash payments 
(including all fees and points paid or received that form an integral part of the effective interest rate, transaction costs and 
other premiums or discounts) through the expected life of the financial liability to the amortised cost of a financial liability. 

Financial liabilities measured at fair value through profit or loss 

Financial liabilities held at fair value through the profit or loss comprise warrants on initial recognition. The warrants are 
initially measured at fair value and are carried in the statement of financial position at fair value. Subsequent to the initial 
recognition,  the  warrants  are  remeasured  to  fair  value  at  each  financial  period  end  date.  The  changes  in  fair  value  are 
recognised in the statement of comprehensive income.  

44 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

2.       ACCOUNTING POLICIES (continued) 

(i)       Financial liabilities (continued) 
All instruments for which fair value is recognised or disclosed are categorised within the fair value hierarchy, which consists 
of the following 3 levels: 
• 
• 

Quoted prices (unadjusted), in active markets for identical assets or liabilities (level 1); 
Inputs other than quoted prices included within level 1 that are observable for the asset or liability, either directly or 
indirectly (level 2); 
Inputs for the asset or liability that are not based on observable market data (that is, unobservable inputs), (level 3). 

• 

Derivative instruments 

Derivative liabilities are carried in the consolidated statement of financial position at fair value with changes in fair value 
recognised in the profit and loss. The Group does not hold or issue derivative instruments for speculative or hedging purposes. 
Other than these derivative financial instruments, the Group does not have any liabilities held for trading nor has it designated 
any financial liabilities as being at fair value through profit or loss. The fair value of derivatives is determined appropriate 
valuation techniques, including pricing models, and observable market inputs. 

Transaction costs associated with hybrid instruments are allocated to their equity and liability components on the basis of their 
fair values at initial recognition. Transaction costs associated with derivative liabilities classified as fair value through the 
profit and loss are recognised  immediately in the profit and loss, transaction costs associated with equity are treated as a 
deduction in equity. 

Share capital 

(j) 
Ordinary shares are classified as equity.  Incremental costs directly attributable to the issue of shares or options are shown in 
equity as a deduction, net of tax, from the proceeds. 

Research and development expenditure 

(k) 
Research costs are expensed through the income statement as they are incurred. Research and development expenses include, 
among other costs, costs incurred by outside laboratories and other accredited facilities in connection with clinical trials and 
preclinical studies.  

Under IAS 38, development costs are only capitalised after technical and commercial feasibility of the asset for sale or use 
have been established. The company must intend and be able to complete the asset and either use it or sell it and be able to 
demonstrate how the asset will generate future economic benefit. If the company cannot distinguish between the research and 
the development phase, then all costs are expensed as research costs. 

Property, plant and equipment 

(l) 
Property, plant and equipment are measured at cost, including directly attributable costs, less accumulated depreciation and 
excluding  day-to-day  servicing  expenses.    The  assets  residual  values  and  useful  lives  are  reviewed,  and  adjusted  if 
appropriate, at the end of each reporting period. 

Depreciation is calculated on a straight-line basis over the useful life of the assets at annual rates as follows: 

Computers, peripheral and scientific equipment 
Office furniture and equipment 

    33% 
    33% 

The Group reviews all long-lived assets for impairment whenever events or circumstances indicate the carrying amount of 
such assets may not be recoverable. Recoverability of assets to be held or used is measured by comparison of the carrying 
value of the asset to the future undiscounted net cash flows expected to be generated by the asset. If such asset is considered 
to be impaired, the impairment recognised is measured by the amount by which the carrying value of the asset exceeds the 
discounted future cash flows expected to be generated by the asset. 

45 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

2.       ACCOUNTING POLICIES (continued) 

Intangible assets 

(m) 
Patent acquisition costs and related capitalised legal fees are recognised at historical cost. Patents have a finite useful life and 
are  carried  at  cost  less  accumulated  amortisation.  Amortisation  is  calculated  using  the  straight-line  basis  method  and  are 
amortised over the shorter of the legal or useful life. The estimated useful life for current patents is twenty two years. 

The Group expenses costs associated with maintaining and defending patents subsequent to their issuance in the period the 
costs are incurred. 

Investments 

(n) 
Investments in subsidiary undertakings are stated at cost less provisions for impairment. Investments are assessed for the 
presence of impairment indicators, if any indicators are present then an impairment review is conducted. See note 10 for 
additional details on the Parent’s impairment assessment. 

Share-based payments and warrants 

(o) 
Where share options or warrants are awarded to directors and employees, the fair value of the options or warrants at the 
grant date  is charged to the consolidated income statement over the vesting period. Non-market vesting conditions are 
taken  into  account  by  adjusting  the  number  of  equity  instruments  expected  to  vest  at  each  balance  sheet  date  so  that, 
ultimately, the cumulative amount recognised over the vesting period is based on the number of options that eventually 
vest. Market vesting conditions are factored into the fair value of the options and warrants granted. As long as all other 
vesting conditions are satisfied, a charge is made irrespective of whether the market vesting conditions are satisfied. The 
cumulative expense is not adjusted for failure to achieve a market vesting condition. 

Where the terms and conditions of options and warrants are modified before they vest, the increase in the fair value of the 
options and warrants, measured immediately before and after the modification, is also charged to the consolidated income 
statement over the remaining vesting period. 

When the options and warrants are exercised, the company issues new shares. The proceeds received net of any directly 
attributable transaction costs are credited to share capital (nominal value) and share premium when the options and warrants 
are exercised. 

When  share  options  and  warrants  lapse,  any  amounts  credited  to  the  share-based  payments  reserve  are  released  to  the 
retained earnings reserve. 

Where warrants and options issued with settlement criteria that outside fixed for fixed criteria as outlined by IAS 32 (i.e. 
fixed number of shares for fixed amount of cash) the resulting fair value of the instruments issued will be classified in 
financial liabilities. 

Finance income and expenses 

(p) 
Interest income and expenses are recognised using the effective interest method.  It mainly comprises of changes in the fair 
value of financial assets and liabilities that are measured at fair value through the income statement and exchange gains 
and losses which is reported on a net basis in the statement of comprehensive loss.  

Deferred taxation 

(q) 
Deferred tax is provided in full, using the liability method, on temporary differences arising between the tax bases of assets 
and liabilities and their carrying values in the financial statements.  The deferred tax is not accounted for if it arises from 
initial  recognition  of  an  asset  or  liability  in  a  transaction,  other  than  a  business  combination,  that  at  the  time  of  the 
transaction does not affect either the accounting or taxable profit or loss.  Deferred tax is determined using tax rates (and 
laws) that have been enacted or substantially enacted by the balance sheet date and are expected to apply when the related 
deferred tax asset is realised or the deferred tax liability is settled. 

Deferred tax assets are recognised to the extent that it is probable that future taxable profit will be available against which 
temporary differences can be utilised. 

46 

 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

2.       ACCOUNTING POLICIES (continued) 

Critical accounting estimates and judgements 

(r) 
The  Group  makes  estimates  and  assumptions  concerning  the  future.  The  preparation  of  financial  statements  requires 
management and the Board of Directors to make estimates and judgments that affect reported amounts of assets, liabilities, 
revenues and expenses, and related disclosure of contingent assets and liabilities. These estimates are based on historical 
experience and various other assumptions that management and the Board believe are reasonable under the circumstances, 
the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not 
readily  apparent  from  other  sources.  Actual  results  may  differ  from  these  estimates  under  different  assumptions  or 
conditions, significantly impacting earnings and financial position. 

Management believes that the following areas, all of which are discussed and separately marked in the respective sections 
of  Note  1  “Accounting  Policies,”  comprise  the  most  difficult,  subjective  or  complex  judgments  it  has    to  make  in  the 
preparation  of  the  financial  statements:  Assessment  of  the  capitalisation  of  research  and  development  expenditure, 
calculation  and  classification  of  share  based  payments  and  the  assessment  of  the  carrying  value  of  the  subsidiary  for 
impairment.  

Key accounting judgements 
Research and Development: Under IAS 38: Intangible Assets, the Group must determine whether to recognise research 
costs incurred as an expense or asset. Depending on the development stage of a project determines whether an expense can 
be capitalised. Difficulties can arise at determining the stage of a project. No costs have been capitalised in the year ended 
31 December 2023 given the absence of any regulatory approval which the directors considered relevant in determining 
any probably future economic benefits. 

Classification of warrants: The Directors consider the September 2022 warrants to represent a derivative liability due to 
the potential modification of the exercise price under certain conditions that the Directors believe are possible to occur. 
This modification results in the warrants failing the ‘fixed for fixed’ test, as outlined in IAS 32 para 16, which is required 
to recognise the warrants as equity instruments. This test requires the Company to provide a fixed number of shares for a 
fixed  amount  of  cash  on  exercise  of  the  warrants  which  would  not  be  the  case  should  the  exercise  price  be  modified. 
Accordingly, the September 2022 warrants are recognised as derivative liabilities, whereby the fair value must be assessed 
at each balance sheet date with a review of the underlying inputs undertaken. 

Key accounting estimates and assumptions  
Share based payments: The Group issues share options and warrants to employees, service providers and investors. Where 
share  options  and  warrants  are  issued  in  return  for  services,  appropriate  valuation  methods  are  used  to  recognise  an 
appropriate expense is recognised in the financial statements. These valuation methods are subject to significant estimation 
as outlined in note 16. Where warrants issued to investors are classified as free-standing liabilities, they are remeasured to 
fair value at each reporting date for which both judgement and estimation is required in relation based on unobservable 
valuation input assumptions, resulting in a higher degree of estimation uncertainty. 

Investment  in  subsidiary:  The  Parent  must  continually  assess  the  carrying  value  of  investments  in  subsidiaries  for 
indications of impairment. Indications of impairment are considered with reference to the Group’s market capitalisation, 
internal  assessment  of  the  ongoing  contribution  of  intellectual  property  and  any  other  indications  of  obsolescence  and 
progress in line with the Group’s business plan. See note 10 for further information of assumptions and estimates made. 

47 

 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

3.            EXPENSES BY NATURE 

The operating loss is stated after charging/(crediting): 

Employee benefit expense (see below) 
Amortisation – intangibles  
Exchange loss 
Auditors’ remuneration 
- fees for the audit of the Group and Parent Company financial 
statements 

Employee benefit expense 
Wages and salaries 
Employer taxes 
Share-based payments 
   Total employee benefit expense 

The average number of persons (including directors) 
 employed by the group during the year was as follows: 
  Office and administration 

Key management remuneration 
Wages and salaries 

2023 
$000 

5,818 
4 
384 

65 

2023 
$000 

4,261 
407 
1,150 
5,818 

2022 
$000 

7,002 
4 
453 

45 

2022 
$000 

5,747 
520 
735 
7,002 

18 

17 

1,555 

3,054 

The  key  management  is  considered  to  be  the  directors  and  senior  management  team.  Details  of  directors’ 
remuneration and share based compensation can be seen within the Directors’ Remuneration Report beginning on 
page 13. 

4. 

NET FINANCE INCOME/(LOSS) 

Interest income 
Interest expense 
Other  

5. 

INCOME TAX CREDIT 

Current tax: 
Research and development tax credit receivable for current year 
Current tax on losses for the year 
Adjustment in respect of prior years  
Overseas current tax 

Deferred tax: 
Origination and reversal of temporary differences 
Tax on loss on ordinary activities 

48 

2023 
$000 

82 
(1) 
330 
413 

2023 
$000 

(1,200) 
- 
(28) 
39 
(1,189) 

- 
(1,189) 

2022 
$000 

46 
(25) 
(596) 
(575) 

2022 
$000 

- 
(2,865) 
393 
- 
(2,472) 

- 
(2,472) 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

5. 

INCOME TAX CREDIT (continued) 

The tax assessed in the year is different from the standard rate of corporation tax in the UK of 23.52% in 2023 
(2022:19%). From 1 April 2023 the UK Government increased the corporation tax rate to 25% on profits above 
$318,300 (£250,000). Companies with profits of $63,660 (£50,000) or less will be taxed at 19% and companies 
with profits between $63,660 (£50,000) and $318,300 (£250,000) will pay tax at 25% that is reduced by marginal 
relief on a sliding scale. 

The differences are explained below:  

Loss before tax  

(13,429) 

(19,483) 

Loss on ordinary activities before tax multiplied by the standard  
companies’ rate of tax in the UK 

(3,158) 

(3,702) 

Effects of: 
Difference in overseas tax rates 
Deferred tax asset on losses not recognised  
Expenses not deductible for tax purposes 
Enhanced research and development relief  
Surrender of tax losses for R&D  
Adjustment in respect of prior years 

  Tax credit 

(26) 
3,308 
(2,664) 
2,569 
(1,189) 
(29) 
(1,189) 

- 
1,724 
570 
1,408 
(2,472) 
- 
(2,472) 

The group has accumulated losses available to carry forward against future trading profits of $122,751,392 (2022: 
$109,535,630).  No deferred  tax  asset  has  been  recognized in  respect of  tax  losses  since it  is  uncertain  at  the 
balance  sheet  date  as  to  whether  future  profits  will  be  available  against  which  the  unused  tax  losses  can  be 
utilized. The estimated value of the deferred tax asset not recognized, measured at a standard rate  of 25% is 
$30,720,305 (2022: $27,426,425). 

6. 

LOSS ATTRIBUTABLE TO THE PARENT COMPANY 

The parent Company has taken advantage of section 408 of the Companies Act 2006 and has not included its own 
profit and loss account in these financial statements.  The parent Company had a loss for the year of $18,255,410 
(2022: $17,280,833 ). 

7. 

BASIC AND DILUTED LOSS PER SHARE  
The calculation of basic and diluted loss per share is based on the loss attributable to ordinary shareholders of 
$12,239,823 (2022: $17,010,978) and a weighted average number of Ordinary Shares outstanding during the year 
ended 31 December 2023 of 9,788,980,193 (2022: 6,243,462,410) calculated below. As a loss-making group, 
outstanding share options are considered antidilutive and therefore basic and diluted loss per share are considered 
to be equal. 

Loss attributable to ordinary shareholders   

2023 
$000 

12,240 

2022 
$000 

17,011 

49 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

7. 

BASIC AND DILUTED LOSS PER SHARE (Continued) 

Weighted average number of ordinary shares 
Number of shares in issue at the beginning of the year 
Effect of shares issued during year 
Weighted average number of ordinary shares in issue for the year  

2023 
      Number 

2022 
      Number 

7,444,917,123 
2,344,063,070 
9,788,980,193 

4,292,112,667  
1,951,349,743  
6,243,462,410  

8. 

INTANGIBLE ASSETS 

GROUP: 

Patent acquisition costs 
Cost 
At 1 January  
At 31 December  

Amortisation 
At 1 January  
Charge for the year 
Exchange rate difference 
At 31 December  

Net Book Value 
At 31 December  

9. 

PROPERTY PLANT AND EQUIPMENT 

GROUP & COMPANY: 

Office furniture and equipment  
Cost 
At 1 January  
Additions 
At 31 December  

Depreciation 
At 1 January  
Charge for the year 
At 31 December  

Net Book Value 
At 31 December  

50 

2023 
$000 

95 
95 

(78) 
(4) 
1 
(81) 

2022 
$000 

95 
95 

(72) 
(4) 
(2) 
(78) 

14 

17 

2023 
$000 

172 
- 
172 

(172) 
- 
(172) 

2022 
$000 

172 
- 
172 

(172) 
- 
(172) 

- 

- 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

10. 

INVESTMENTS IN SUBSIDIARIES 

COMPANY: 

Cost 
At 1 January 2022 
At 31 December 2022 

Impairment 
At 1 January 2022 
At 31 December 2022 

Cost 
At 1 January 2023 
At 31 December 2023 

Impairment 

At 1 January 2023 

Charge 

At 31 December 2023 

Net book value 

At 31 December 2023 

At 31 December 2022 

Investments in 
Subsidiary 
Undertakings 
$000 

20,339 
20,339 

- 
- 

20,339 
20,339 

- 

2,000 

2,000 

18,339 

20,339 

Impairment assessment on Investments 
As at 31 December 2023, the Group assessed whether there were any indicators of impairment of the investment 
and intercompany receivable balance relating to Volution Immuno Pharmaceuticals SA (“Volution”) recognized 
in the Parent Company’s balance sheet. 

On 29 December 2023, the last trading day of the year, Akari Therapeutics Plc had 6,600,922 ADSs outstanding 
that  traded  at  $3.12,  resulting  in  a  market  capitalization  of  $20.6m.  Management  compared  the  market 
capitalization against the total net assets of the Parent Company and concluded that the carrying values of the net 
assets were higher, which was deemed to be an indicator of impairment of these balances. 

Further to this, management considered the  significant changes in market conditions with an emphasis on the 
biotech  industry  as  whole,  which  has  experienced  declining  stocks  prices,  along  with  fundraising  challenges. 
Factors  contributing  to  the  downturn  including  rising  interest  rates  and  cost  of  capital,  difficulty  developing 
profitable products, political tensions and the uncertainties around the Inflation Reduction Act.  

Lastly,  management  considered  the  Group’s  competition with  respect  to  their  ongoing trials  and  research  and 
development activities, as well as any evidence of obsolescence in certain elements of IP.  
Management  concluded  that  of  the  above  matters,  those  associated  with  the  Group’s  market  capitalization 
represented indicators that prompted the requirement to undertake an impairment review of the investment and 
intercompany receivable balances.  

Given that Volution is the IP holder for the Group, which is not generating revenue due to its early-stage status of 
being a research and development company, management determined its recoverable value by assessing the fair 
value less the costs of disposal (FVLCD) of the entity, rather than perform a discounted cash flow analysis, given 
that  any  projection  of  future cash  flows  from  pre-clinical development  activities  would  be  speculative  and  an 
unreliable measure of value.   

51 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

As part of the  Company’s proposed merger with Peak Bio, Inc. (see note 19), the Company engaged with an 
independent global investment bank to provide a fairness opinion on the transaction, which included an enterprise 
value of the Group. The Directors consider that the enterprise value of the Group is inherently driven by the value 
of its accumulated intellectual property (which is owned by Volution) and therefore an implied range of fair values 
for its investment in Volution was derived from this. 

Based on management’s experience and judgement, while making reference to the valuation implied by the 
aforementioned valuation subject to a fairness opinion and the constraining factors implied by the Group’s 
overall market capitalization, it was determined that it was appropriate to recognise impairment charge totalling 
$5.7m as at 31 December 2023 to reduce the carrying value of the intercompany receivable to $nil and the 
investment in Volution to $18.3m. 

Investments  
The Company directly owns 100% of the issued share capital of the following subsidiaries, which have been 
included in the consolidated financial statements: 

Subsidiary 
Volution Immuno 
Pharmaceuticals SA  
Celsus Therapeutics Inc. 
Morria Biopharma Ltd.  
Akari Malta Limited  

Principal activity 

Development of 
pharmaceutical drugs 
Dormant 
Dormant 
Regulatory 
compliance  

Country of 
incorporation 
Switzerland 

United States 
Israel 
Malta 

Holdings 
Ordinary 

Ordinary 
Ordinary 
Ordinary 

% 
100 

100 
100 
100 

Registered office addresses of subsidiaries: 
Volution Immuno Pharmaceuticals SA : Place Des Eaux-Vives 6, 1207 Geneva, Switzerland 
Celsus Therapeutics Inc: 1209 Orange Street, Wilmington, DE 19801 
Morria Biopharma Ltd: 1209 Orange Street, Wilmington, DE 19801 
Akari Malta Limited:  189 Marina Suites, Marina Street, Pieta, Malta PTA9041  

11.  

TRADE AND OTHER RECEIVABLES 

Due from a related party 
Prepayments and accrued income 
Income tax receivable 
Other receivables  

Group 

2023 
$000 

2022 
$000 

Company 

2023 
$000 

2022 
$000 

- 
299 
1,217 
197 
1,713 

- 
465 
2,386 
100 
2,951 

- 
294 
1,217 
215 
1,726 

3,774 
459 
2,386 
98 
6,717 

During the period, it was determined that the intercompany balance with Volution recognized in the 
Company’s financial statements was to be written off in full. At 31 December 2023, a total balance of $3.7m 
was written off and recognized in the Company’s Statement of Comprehensive Income. Further details on the 
impairment can be found in note 10.  

52 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

12.  

TRADE AND OTHER PAYABLES 

Trade payables 
Accrued expenses 
Other payables 

Group 

2023 
$000 

2022 
$000 

1,671 
1,566 
94 
3,331 

947 
2,086 
94 
3,127 

Company 

2023 
$000 

2022 
$000 

1,417 
1,542 
94 
3,053 

756 
2,070 
94 
2,920 

The directors consider that the carrying value of trade and other payables approximates their fair value. Included 
within other payables is an amount of $94,118 (2022: $94,118) that relates to pre-funded cashless exercise price 
of warrants received.  

13. 

CALLED UP SHARE CAPTIAL  

Issued and fully paid 
Akari Therapeutics, Plc 

As at 1 January 2023 
Issuance of ordinary shares 
Pending issuance of ordinary shares underlying vested 
restricted stock units 
As at 31 December 2023 

2023 
No. of Shares 

7,444,917,123 
5,761,246,400 

28,151,775 

Share 
Capital 
($) 

744,492 
576,125 

2,815 

13,234,315,298 

1,323,432 

ADS Ratio Change 
The Parent’s ordinary shares, $0.0001 par value per share, in the form of American Depositary Shares (“ADSs”), 
currently trade on the Nasdaq Capital Market under the symbol “AKTX”. Effective August 17, 2023, the Parent 
changed the ratio of its ADSs to ordinary shares, par value $0.0001 per share, from one ADS representing 100 
ordinary shares to a new ratio of one ADS representing 2,000 ordinary shares (the “ADS Ratio Change”). All 
ADS and per ADS amounts in the accompanying financial statements and notes thereto have been retroactively 
adjusted for all periods presented to reflect the ADS Ratio Change. 

Issue of shares 
In December 2023, the Parent entered into purchase agreements to sell in a private placement to existing investors, 
Dr. Prudo, the Parent’s Chairman, and Dr. Patel, Parent director, (the “December 2023 Private Placement”) an 
aggregate of 947,868 ADSs (equivalent to 1,895,736,000 ordinary shares) at $2.11 per ADS, for aggregate gross 
proceeds  of  approximately  $2.0  million.  Net  proceeds  from  the  December  2023  Private  Placement  was 
approximately $1.8 million after deducting placement agent fees and other expenses. 

In September 2023, the Parent entered into purchase agreements to sell in a private placement to existing investors, 
including Dr. Ray Prudo, the Parent’s Chairman, and Ms. Rachelle Jacques, the Parent’s then President and CEO 
(the “September 2023 Private Placement”) an aggregate of 551,816 ADSs (equivalent to 1,103,632,000 ordinary 
shares) at $3.30 per ADS, and pre-funded warrants (the “Pre-Funded Warrants”) to purchase up to 48,387 ADSs 
(equivalent to 96,774,000 ordinary shares) at a purchase price per Pre-Funded Warrant of $3.10, for aggregate 
gross proceeds of approximately $2.0 million. The Pre-Funded Warrants are exercisable at an exercise price of 
$0.20  per  ADS  and  will  not  expire  until  exercised  in  full.  The  September  2023  Private  Placement  closed  in 
October 2023 resulting in net proceeds of approximately $1.7 million after deducting placement agent fees and 
other expenses.  

53 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

13.  

CALLED UP SHARE CAPITAL (Continued) 

At  close  of  the  September  2023  Private  Placement,  the  Parent  issued  to  Paulson  Investment  Company,  LLC 
("Paulson"), as placement agent for the September 2023 Private Placement, warrants to purchase 42,550 ADSs 
(equivalent to 85,100,000 ordinary shares) at an exercise price of $4.13 per ADS (representing 125% of the price 
per ADS in the September 2023 Private Placement) and a term expiring on October 6, 2028 (the “October 2023 
Placement Agent Warrants”). The estimated fair value of the October 2023 Placement Agent Warrants on the 
issuance date was approximately $0.1 million. The Parent determined that the Pre-Funded Warrants and October 
2023 Placement Agent Warrants met all of the criteria for equity classification. Accordingly, upon closing of the 
September  2023  Private  Placement,  each  of  the  Pre-Funded  Warrants  and  October  2023  Placement  Agent 
Warrants were recorded as a component of shareholders’ equity. 

On  March  31,  2023,  the  Parent  entered  into  securities  purchase  agreements  with  certain  accredited  and 
institutional investors, including Dr. Ray Prudo, the Parent’s Chairman, (the “March Registered Direct Offering”) 
providing for the issuance of an aggregate of 1,333,333 ADSs (equivalent to 2,666,666,700 ordinary shares) in a 
registered  direct  offering  at  $3.00  per  ADS,  resulting  in  gross  proceeds  of  approximately  $4.0  million.  Net 
proceeds from the March Registered Direct Offering was approximately $3.5 million after deducting placement 
agent fees and expenses. 

See note 19 for details around the issuance of share capital post 31 December 2023. 

14. 

    RESERVES 

The following describes the nature and purpose of each reserve within equity: 

Share premium - Accumulated amounts subscribed for share capital in excess of the nominal value of the share 
capital issued. Costs relating to the issue of shares are offset against share premium. Issue costs incurred in the 
year ended 31 December 2023 offset in share premium were $6,529,000 (31 December 2022: $1,747,975 ). 

Retained earnings – Includes all current and prior period losses  

Other  reserves  -  Accounts  for  all  other  gains  and  losses  reported  by  the  group  and  not  recognised  elsewhere.  
Includes accumulated gains and losses arising from the retranslation of the net assets of overseas entities. 

Share based payment reserve – This includes all movement for share options granted during the period. 

Merger  reserve  –  Merger  reserve  represents  the  premium  on  the  shares  issued  to  acquire  Volution  Immuno 
Pharmaceuticals SA in accordance with the provisions of S612 of the Companies Act 2006. 

Reverse acquisition reserve – The reverse acquisition reserve relates to the reverse acquisition between Celsus 
Therapeutics PLC and Volution Immuno Pharmaceuticals SA on 18 September 2015. 

Capital redemption reserve – Amounts transferred from share capital on redemption of issued shares. 

15. 

  WARRANTS 

On September 14, 2022, the Company’s sale of ADSs to accredited and institutional investors also included the issuance 
of series A and series B warrants. The series A warrants allow the investors to purchase an aggregate of 755,000 ADSs at 
$17.00 per ADS (“Series A warrants”). The Series A warrants are immediately exercisable and expire two years from 
issuance (September 14, 2024). The series B warrants allow the investors to purchase an aggregate of  755,000 ADSs at 
$17.00 per ADS (“Series B warrants”). The Series B warrants are immediately exercisable and expire seven years from 
issuance (September 14, 2029). The Series A warrants and the Series B warrants may be exercised on a cashless basis if 
six months after issuance there is no effective registration statement registering the ADSs underlying the warrants. Pursuant 
to  the  cashless  exercise  provision,  the  warrant  holder  must  make  an  additional  payment  to  the  Company  equal  to  the 
nominal value of an ADS (i.e., $0.0001) per warrant ADS to be issued pursuant to the cashless exercise.  

54 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

15. 

  WARRANTS (Continued) 

The fair value of the Series A and Series B warrants was determined using the Black-Scholes Option Pricing Model, which 
uses various assumptions, including (i) fair value of the Company’s ADSs, (ii) exercise price of the warrant, (iii) expected 
term of the warrant, (iv) expected volatility and (v) expected risk-free interest rate.  

Below are the assumptions used for the fair value calculations of warrants, adjusted where applicable to reflect the change 
in ADS ratio at the year ended 31 December 2023 and 31 December 2022: 

31 December 2023 

 31 December 2022 

Stock price 
Exercise price 
Expected  term  (in 
years) 
Volatility  
Risk-free rate 

Series A 
$3.12 
$17.00 
0.7 

85% 
5.1% 

Series B 
$3.12 
$17.00 
5.7 

95% 
3.9% 

Series A 
$9.40 
$17.00 
1.7 

80% 
4.37% 

Series B 
$9.40 
$17.00 
6.7 

120% 
3.96% 

The following table summarizes the activity in the warrant liability during the year ended 31 December 2023:  

Fair value at 1 January 2023 

Issuance of warrant 

Change in fair value of liability 

Fair value at 31 December 2023  

Series A 
($000) 

1,812 

- 

(1,797) 

15 

Series B 
($000) 

6,040 

- 

(4,082) 

1,238 

Total 
($000) 

7,852 

- 

(6,599) 

1,253 

The following table summarizes the activity in the warrant liability during the year ended 31 December 2022:  

Fair value at 1 January 2022 

Issuance of warrant 

Change in fair value 

Fair value at 31 December 2022  

Series A 
($000) 

- 

5,285 

(3,473) 

1,812 

Series B 
($000) 

- 

9,513 

(3,473) 

6,040 

Total 
($000) 

- 

14,798 

(6,946) 

7,852 

The  Company  is  accounting  for  the  warrants  in  accordance  with  IAS  32  Financial  Instruments:  Presentation.  IAS  32 
provides that the Company’s financial instruments shall be classified on initial recognition in accordance with the substance 
of the contractual arrangement and the definitions of a financial liability or an equity instrument.  

The Company determined that the Series A and Series B warrants (collectively, the “September 2022 Warrants”) represent 
freestanding  financial  instruments  because  based  on  the  warrant  term  their  volatility  input  would  preclude  an  option 
contract from being considered indexed to an entity’s own stock. 

The grant date fair value of the September 2022 Warrants totaled $14,798,000, which exceeded the $12,835,000 proceeds 
received  from  the  sale  of  ADSs.  The  Company  concluded  that  the  September  2022  Registered  Direct  Offering  was 
conducted on an arm’s length basis and it used an external subject matter valuation expert to determine the fair value of 
the warrants. The excess fair value over the proceeds received of $1,963,000 at grant date was recognized as a non-operating 
expense in the consolidated statement of operations and comprehensive loss.  

55 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

In connection with the September 2022 Registered Direct Offering, the Company expensed $1.7 million of issuance costs 
associated with the September 2022 Warrants during the year ended December 31, 2023, which have been recognized as 
general and administrative expense in the consolidated statement of operations and comprehensive loss.  

At December 31, 2023, the fair value of the September 2022 Warrants was $1,253,000. 

The following table summarises the Company’s outstanding warrants as at 31 December 2023 and 2022: 

2023 

2022 

Number 
of ADS 
Warrants 

2,077,673 

90,937 

2,168,610 

Weighted 
Average 
Exercise Price 
$ 
22.85 

2.04 

21.97 

Number  
of ADS 
Warrants 

250,281 

2,059,401 

2,077,673 

Weighted  
Average 
Exercise Price 
$ 
49.06 

18.31 

22.85 

Outstanding at 1 January 2023 

Granted during the year 

Outstanding at 31 December 2023 

16. 

SHARE-BASED EQUITY AWARDS 

2023 Equity Incentive Plan  
On June 30, 2023, the Company’s shareholders approved the 2023 Equity Incentive Plan (the “2023 Plan”), which provides 
for the grant of stock options, both incentive stock options and nonqualified stock options, stock, with and without vesting 
restrictions, restricted stock units and stock appreciation rights, to be granted to employees, directors and consultants. The 
Company is permitted to grant up to 980,000,000 ordinary share incentive awards under the 2023 Plan. 

All  outstanding  ordinary  shares  under  the  2014  Equity  Incentive  Plan  (the  “2014  Plan”)  relating  to  stock  options  and 
restricted stock units may be issued under the 2023 Plan if such awards are forfeited, cancelled or expire unexercised. As 
of June 30, 2023, the Company had 855,637,300 ordinary shares underlying outstanding equity awards under the 2014 
Plan,  consisting  of  stock  options  and restricted  stock  units.  Accordingly,  the  total  number  of ordinary  shares  that  may 
ultimately be issued under rights granted under the 2023 Plan, including shares subject to outstanding grants under the 
2014 Plan, shall not exceed 1,835,637,300 ordinary shares. In addition, if an award issued under the 2023 Plan is terminated 
or results in any shares not being issued, the unissued or reacquired shares shall again be available for issuance under the 
2023 Plan. As of December 31, 2023, the Company had 247,798,825 ordinary shares underlying outstanding equity awards 
under the 2023 Plan and 765,819,200 ordinary shares were available for future issuance under the 2023 Plan. 

The 2023 and 2014 Plans provide that they be administered by the compensation committee of the board of directors. The 
exercise price for stock option awards may not be less than 100% of the fair market value of the Company’s ordinary shares 
on the date of grant and the term of awards may not be greater than ten years. The Company determines the fair value of 
its ordinary shares based on the quoted market price of its ADSs. Vesting periods are determined at the discretion of the 
compensation committee. Awards granted to employees typically vest over two to four years and directors over one year. 

2014 Equity Incentive Plan 
Under  the  2014  Plan  the  Company  was  authorized  to  grant  stock  options,  restricted  stock  units  and  other  awards,  to 
employees, members of the board of directors and consultants. Upon effectiveness of the 2023 Plan no further awards were 
available  to be  issued  under  the  2014  Plan.  As  of  December  31,  2023,  the  Company  had  789,393,500 ordinary  shares 
underlying outstanding equity awards under the 2014 Plan, consisting of stock options and restricted stock units. 

56 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

16. 

SHARE-BASED EQUITY AWARDS (Continued) 

Share Options 
The following is a summary of the Company’s stock option activity under the 2014 Plan and the 2023 Plan for the year 
ended December 31, 2023: 

2023 

2022 

Outstanding at 1 January 2023 

Granted during the year 

Forfeited/expired during the year 

Outstanding at 31 December 2023 

Number 

513,673,885 

223,690,700 

(86,127,185) 

651,237,400 

Exercisable (Vested) at 31 December 2023 

212,510,100 

Weighted 
Average 
Exercise Price 
$ 
0.02 

0.00 

0.03 

0.01 

0.02 

Number 

  142,949,035 

  409,396,700 

(38,671,850) 

  513,673,885 

  128,451,772 

Weighted 
Average  
Exercise Price 
$ 
0.07 

0.01 

0.15 

0.02 

0.04 

The weighted average remaining contractual life of the options is 8.5 years (2022: 8.7 years ).  

The following is a summary of the Group's share options granted separated into ranges of exercise price: 

Exercise  
price 
(range) ($) 
>0.01 
0.01-0.018 
0.02-0.05 
0.12-0.32 

Options 
outstanding 
at 31 
December 
 2023 

  307,090,700 
  291,596,700 
46,700,000 
5,850,000 

651,237,400 

Weighted 
average 
remaining 
contractual 
life (years) 
9.3 
8.4 
- 
- 

Weighted 
average  
exercise 
price ($) 
0.01 
0.01 
0.02 
0.16 

Options 
exercisable 
at 
December 
31, 2023 
50,986,338 
  108,973,763 
46,700,000 
5,850,000 
212,510,100 

Exercise  
price 
(range) ($) 
<0.01 
0.01 
0.02-0.05 
0.12-0.32 

Options 
outstanding 
at 31 
December 
 2022 

  106,500,000 
  286,896,700 
  102,000,000 
18,227,185 
  513,673,885 

Weighted 
average 
remaining 
contractual 
life (years) 
9.8 
9.3 
6.8 
3.3 

Weighted 
average  
exercise 
price ($) 
0.01 
0.01 
0.02 
0.16 

Options 
exercisable 
at 
December 
31, 2022 

- 
29,674,587 
80,500,000 
18,277,185 
128,451,772 

Remaining 
contractual 
life for 
exercisable 
options 
(years) 
9.1 
7.9 
4.9 
2.2 

Weighted 
average  
exercise  
price for 
exercisable 
options ($) 
- 
0.01 
0.02 
0.16 

Remaining 
contractual 
life for 
exercisable 
options 
(years) 
- 
9.2 
6.3 
3.3 

Weighted 
average  
exercise  
price for 
exercisable 
options ($) 
- 
0.01 
0.02 
0.16 

57 

 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
  
  
  
  
  
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
  
  
  
  
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

16. 

SHARE-BASED EQUITY AWARDS (Continued) 

The Company measures compensation cost for all share-based awards at fair value on the date of grant and recognizes 
compensation  expense  in  general  administrative  and  research  and  development  expenses  within  its  Consolidated 
Statements of Comprehensive Loss using the straight-line method over the service period over which it expects the awards 
to vest.  

The Company estimates the fair value of all time-vested options as of the date of grant using the  Black-Scholes option 
valuation model, which was developed for use in estimating the fair value of traded options that have no vesting restrictions 
and  are  fully  transferable.  Option  valuation  models  require  the  input  of  highly  subjective  assumptions,  including  the 
expected share price volatility, which is calculated based on the historical volatility of peer companies. The Company uses 
a risk-free interest rate, based on the U.S. Treasury instruments in effect at the time of the grant, for the period comparable 
to the expected term of the option. Given its limited history with share option grants and exercises, the Company uses the 
“simplified” method in estimating the expected term, the period of time that options granted are expected to be outstanding, 
for its grants. 

The  Company classifies its stock-based payments  which are settled in ordinary shares  as equity-classified awards. The 
Company  measures  equity-classified  awards  at  their  grant  date  fair  value  and  does  not  subsequently  re-measure  them. 
Compensation  costs  related  to  equity-classified  awards  generally  are  equal  to  the  grant-date  fair  value  of  the  award 
amortized over the vesting period of the award.  

Below are the weighted-average assumptions used for the options granted in the year ended 31 December 2023:  

Expected dividend yield 

Expected volatility 

Risk-free interest 

Expected life 

2023 

0% 

98.7% 

3.8% 

6.0 years 

Below are the assumptions used for the options granted in the year ended 31 December 2022:  

Expected dividend yield 

Expected volatility 

Risk-free interest 

Expected life 

2022 

0% 

   72.8%-120.0% 

1.46%-4.34% 

   5.5-6.25 years 

Restricted Stock Units 
The 2014 Plan provided, and the 2023 Plan provides, for the award of restricted stock units (“RSUs”). RSUs are granted 
to employees that are subject to time-based vesting conditions that lapse between one year and four years from date of 
grant, assuming continued employment. Compensation cost for time-based RSUs, which vest only on continued service, 
is recognized on a straight-line basis over the requisite service period based on the grant date fair of the RSU's, which is 
derived from the closing price of the Company's ADS's on the date of grant. 

58 

 
 
 
 
 
 
  
 
 
  
  
  
  
  
  
 
 
  
  
 
 
 
  
  
  
  
  
 
 
  
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

16. 

SHARE-BASED EQUITY AWARDS (Continued) 

The following table summarizes the Company’s restricted stock activity for the year ended December 31, 2023: 

2023 

2022 

Weighted 
Average  
Grant Date 
Fair Value 

$ 

0.01 

0.00 

0.01 

0.00 

Number 

21,475,400 

407,843,000 

(43,363,475) 

385,954,925 

Number 

- 
  21,475,400 
- 
  21,475,400 

Weighted 
Average 
Grant Date 
Fair Value 

$ 

- 

0.01 

- 

0.01 

Nonvested shares at 1 January 2023 

Granted during the year 

Vested during the year 

Nonvested shares at 31 December 2023 

The fair value of time-based RSUs that vested during the year ended December 31, 2023 was approximately $0.2 million. 
No time-based RSUs vested during the year ended December 31, 2022. 

As of December 31, 2023, 28,151,775 ordinary shares underlying vested time-based RSUs were pending issuance due to 
administrative reasons. 

Share-based Compensation Expense 
During the year ended 31 December 23 the Group recognized $1,150,000 (2022: $735,000 ) in share-based compensation 
expenses for employees and directors. At 31 December 2023, there was approximately $1.7 million and $0.6 million of 
unrecognized compensation cost related to unvested stock options and time-based RSUs, respectively.  

17. 

FINANCIAL INSTRUMENTS 

The Group’s activities expose it to financial risks: foreign current risk and credit risk and also non-financial risks: market 
risk.  The  Group’s  overall  risk  management  program  focuses  on  unpredictability  and  seeks  to  minimised  the  potential 
adverse  effects  on  the  Group’s  financial  performance.  The  Board,  on  a  regular  basis,  reviews  key  risks  and,  where 
appropriate, actions are taken to mitigate the key risks identified.  

The fair value measurement of the Group’s financial and non-financial assets and liabilities utilities market observable inputs 
and data as far as possible. Inputs used in determining fair value measurements are categorised into different levels based on 
how observable the inputs used in the valuation technique utilised are (the “fair value hierarchy”): 

Level 1: Quoted prices in active markets for identical items; 
Level 2: Observable direct or indirect inputs other than Level 1 inputs; and 
Level 3: Unobservable inputs, thus not derived from market data. 

The classification of an item into the above levels is based on the lowest level of the inputs used that has a significant effect 
on the fair value measurement of the item. There have been no transfers between levels during the period.  

59 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

17. 

FINANCIAL INSTRUMENTS (Continued) 

The Group has the following categories of financial instruments as at 31 December 2023: 

Financial assets measured at amortised cost: 
Other receivables 

Financial liabilities measured at amortised cost: 
Trade payables and other payables 

Financial liabilities measured at FVPL 
Warrant liability (Note 15) 

2023 
$000 

198 

2022 
$000 

- 

3,331 

3,127 

1,253 

7,852 

There is no significant difference between the fair value and the carrying value of financial instruments. 

All financial instruments are classified as current assets and current liabilities. There are no non-current financial instruments 
as at 31 December 2023. 

For details of valuation techniques and significant unobservable inputs related to determining the fair value of the warrant 
liability, which is classified in level 3 of the fair value hierarchy, refer to Note 15. 

The Group’s risk management policies are established to identify and analyse the risks faced by the Group, to set appropriate 
risk  limits  and  controls,  and  to  monitor  risks  and  adherence  limits.  Risk  management  policies  and  systems  are  reviewed 
regularly to reflect changes in market conditions and the Group’s activities. 

Financial risks factors: 
The Group's activities are exposed to foreign exchange risk. The Group's comprehensive risk management plan focuses on 
activities and strategies that reduce adverse effects on the financial performance of the Group to a minimum.  

Foreign currency risk: 

1. 
The  Group  is  exposed  to  foreign  currency  risk  arising  on  cash  and  cash  equivalents  and  receivables  denominated  in a 
currency other than the respective functional currencies of the Group. The currencies in which these transactions primarily 
are denominated are GBP Sterling (GBP). Swiss Franc (CHF) and Euro (EUR).  

The following balances held in foreign currency at the reporting date are:  

GBP 
CHF 
EUR 
Total net exposure 

Group 

Company 

31 December 
2023 
$000 

31 December 
2022 
$000 

31 December 
2023 
$000 

31 December 
2022 
$000 

954 
- 
1,471 

2,425 

152 
10 
41 
203 

954 
- 
1,471 
2,425 

152 
10 
41 
203 

60 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

17. 

FINANCIAL INSTRUMENTS (Continued) 

Sensitivity analysis  
A 10 percent strengthening of USD against the respective currencies at 31 December 2023 would have decreased equity 
and profit and loss by the amounts shown below: 

Group: 

GBP 
CHF 
EUR 
Total net exposure 

Company: 

GBP 
CHF 
EUR 
Total net exposure 

Profit and loss 

Equity 

31 December 
2023 
$ 

31 December 
2022 
$ 

31 December 
2023 
$ 

31 December 
2022 
$ 

(95) 
- 
(147) 
(242) 

(15) 
(4) 
(1) 
(20) 

(95) 
- 
(147) 
(242) 

(15) 
(4) 
(1) 
(20) 

Profit and loss 

Equity 

31 December 
2023 
$ 

31 December 
2022 
$ 

31 December 
2023 
$ 

31 December 
2022 
$ 

(95) 
- 
(147) 
(242) 

(15) 
(4) 
(1) 
(20) 

(95) 
- 
(147) 
(242) 

(15) 
(4) 
(1) 
(20) 

Foreign currency risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate because of 
changes in foreign exchange rates. The Group's exposure to the risk of changes in foreign exchange rates relates primarily to 
the Group's operating activities when expenses are denominated in a different currency from the Group's functional currency.   

Credit risk: 
Credit risk is the risk that a counterparty will not meet its obligations under a financial instrument or supplier contract, leading 
to a financial loss. Financial instruments that potentially subject the Group to concentrations of credit risk consist principally 
of cash and cash equivalents. Cash and cash equivalents and short-term deposits are deposited with major banks in Europe 
and  the  United  States,  and  invested  mostly  in  U.S.  dollars  and  Great  British  Pounds.  Such  redeemed  upon  demand  and 
therefore bear low risk.  

Market risk: 
The  Group's  financial  instruments  comprise  equity  investments,  cash  and  various  items  such  as  trade  debtors  and  trade 
creditors that arise directly from its operations. The main risk arising from the Groups financial instruments is liquidity risk. 
During the period the Group issued to investors Series A and Series B Warrants, exercisable to purchase in the aggregate 
up to 755,000 ADSs at an exercise price of $17.00 per ADS each. On initial recognition both the Series A and Series B 
Warrant  instruments  met  the  definition  of  a  derivative  instrument  and  was  subsequently  recognized  as  such.  As  at  31 
December 2023 the Group has sufficient cash to cover the Warrant liability and as such the Directors do not consider this 
to be a significant risk. 

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AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

18.      RELATED PARTY TRANSACTIONS 

The following transactions were carried out with related parties: 

The Doctors Laboratory 
The  Company  leases  its  offices  in  London  from  The  Doctors  Laboratory  (“TDL”)  and  has  incurred  expenses  of 
approximately $148,000 plus VAT during the year ended  31 December 2023 (2022: $129,000). David Byrne, a former 
non-employee director of the Company, is also the Chief Executive Officer of TDL and Dr. Ray Prudo, the Company’s 
Chairman, is Non-Executive Chairman of the Board of Directors of TDL. 

Company  received  laboratory  testing  services  for  its  clinical  trials  provided  by  TDL,  including  certain  administrative 
services, and has incurred expenses of approximately $122,000 plus VAT during the year ended 31 December 2023 (2022: 
$89,000).  

The Company recorded payable balances to TDL of  approximately $70,000 plus VAT as of December 31, 2023 (2022: 
$23,000).  

Other 
A non-employee director of the Company began providing business development consulting services in January 2018. The 
consulting agreement was terminated in November 2022. The  Company has incurred expenses of  $Nil during the year 
ended December 31, 2023 (2022: $92,000), relating to these consulting services. 

19.       POST BALANCE SHEET EVENTS 

On March 4, 2024, the Company entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Peak 
Bio, Inc. (“Peak Bio”) and Pegasus Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of Akari 
(“Merger Sub"), pursuant to which, upon the terms and subject to the conditions thereof, Merger Sub will be merged with 
and into Peak Bio (the “Merger”), with Peak Bio surviving the Merger as a wholly-owned subsidiary of Akari. 

On March 26, 2024, the Company entered into an amended and restated definitive purchase agreement with certain 
existing investors, pursuant to which the Company sold and issued in a private placement an aggregate of 1,320,614 
ADSs (equivalent to 2,641,228,000 ordinary shares) at $1.48 per ADS, for aggregate gross proceeds of approximately 
$2.0 million (the “March 2024 Private Placement”). The March 2024 Private Placement closed on March 28, 2024. Net 
proceeds from the March 2024 Private Placement was approximately $1.7 million after deducting placement agent fees 
and other expenses. 

On May 1, 2024, the Company began to implement a reduction-in-force of approximately 67% of its total workforce as a 
result of the recently announced program prioritization under which the Company’s HSCT-TMA program was 
suspended. The reduction-in-force is part of an operational restructuring plan and includes the elimination of certain 
senior management positions. The purpose of the restructuring plan, including the reduction-in-force, is to reduce HSCT-
TMA related operating costs, while supporting the execution of the Company’s long-term strategic plan. The Company 
currently expects expenses related to the reduction-in-force, consisting primarily of cash severance and termination 
benefits and related costs, to be in the range of approximately $3.1 million to $3.2 million, which includes approximately 
$1.6 million of non-cash expenses related to vesting of equity awards. The Company expects these costs to be payable 
through the fourth quarter of 2024. These estimates are subject to a number of assumptions, and actual results may differ.  

The Company may also incur additional costs not currently contemplated due to events that may occur as a result of, or 
that are associated with, the operational restructuring plan, including the reduction-in-force. 

On May 10, 2024, the Company entered into convertible promissory notes with existing investors and directors, Dr. 
Prudo and Dr. Patel (the “May 2024 Notes”) for an aggregate of $1.0 million in gross proceeds. The May 2024 Notes 
bear interest at 15% per annum, which may be increased to 17% upon the occurrence of certain events of default as 
described therein, and the principal and all accrued but unpaid interest is due on the date that is the earlier of (a) ten (10) 
business days following the Company’s receipt of a U.K. research and development tax credit from HM Revenue and 
Customs, and (b) November 10, 2024. Provided, however, at any time or times from the date of the note and until the 
tenth business day prior to closing of the Merger, the note holders are entitled to convert any portion of the outstanding 
and unpaid amount, including principal and accrued interest, into Company ADSs at a fixed conversion price equal to 
$1.59, subject to certain restrictions. 

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AKARI THERAPEUTICS PLC  

NOTES TO THE FINANCIAL STATEMENTS 

FOR THE YEAR ENDED 31 DECEMBER 2023 

19.       POST BALANCE SHEET EVENTS (Continued) 

On May 29, 2024, the Company entered into a definitive agreement (the “May 2024  Purchase Agreement”) with certain 
investors, Dr. Ray Prudo and Dr. Patel, pursuant to which the Company agreed to sell and issue in a private placement (the 
“May  2024  Private  Placement”)  an  aggregate  of  4,029,754  unregistered  ADSs,  and  Series  C  Warrants  (the  “Series  C 
Warrants”) to purchase up to 4,029,754 ADSs, at a per unit price of $1.885 per ADS and Series C Warrant. The May 2024 
Purchase  Agreement  also  contains  representations,  warranties,  indemnification  and  other  provisions  customary  for 
transactions of this nature. The May 2024 Private Placement closed on May 31,  2024. Upon the closing of the Private 
Placement,  the  Company  issued  and  sold  3,817,553  ADSs  and  Series  C  Warrants  to  purchase  up  to  3,817,553  ADSs 
pursuant to the May 2024 Purchase Agreement, and the remaining 212,201 ADSs and Series C Warrants to purchase up to 
212,201 ADSs will be issued and sold by the Company at a later date upon the receipt of the proceeds related thereto. Net 
proceeds from the May 2024 Private Placement is expected to be approximately $6.6 million after deducting placement 
agent fees and other expenses. 

20.  ULTIMATE CONTROLLING PARTY 

The directors do not believe that there is an ultimate controlling party of the Group. 

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