Quarterlytics / Healthcare / Biotechnology / CNS Pharmaceuticals, Inc.

CNS Pharmaceuticals, Inc.

cnsp · NASDAQ Healthcare
Claim this profile
Ticker cnsp
Exchange NASDAQ
Sector Healthcare
Industry Biotechnology
Employees 1-10
← All annual reports
FY2020 Annual Report · CNS Pharmaceuticals, Inc.
Sign in to download
Loading PDF…
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C., 20549

FORM 10-K/A
(Amendment No. 2)

☒

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2020

OR

☐

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from _________________ to ___________________

Commission File Number: 001-39126

CNS Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in its Charter)

Nevada
(State or Other Jurisdiction of
Incorporation or Organization)

82-2318545
(I.R.S. Employer Identification No.)

2100 West Loop South, Suite 900
Houston, Texas 77027
(Address of Principal Executive Offices) (Zip Code)

Registrant’s Telephone Number, including Area Code: 800-946-9185

Securities registered pursuant to Section 12(b) of the Exchange Act:

Title of each class
Common Stock

Trading Symbol(s)
CNSP

Name of each exchange on which registered
The NASDAQ Stock Market LLC

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    YES  ☐    NO   ☒

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.    YES  ☐    NO   ☒

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12
months (or for such shorter periods as the registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90 days.    YES  ☒    NO  
☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during
the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    YES  ☒    NO   ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth
company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
(check one)

Large accelerated filer   ☐
Non-accelerated filer   ☒

Accelerated filer   ☐
Smaller reporting company   ☒
Emerging growth company   ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial
reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐ 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).    YES  ☐    NO   ☒

The registrant was not a public company as of the last business day of its most recently completed second fiscal quarter and, therefore, cannot calculate the aggregate market
value of its voting and non-voting common equity held by non-affiliates as of such date.

The number of shares of the registrant’s common stock outstanding as of April 28, 2021 was 25,359,059.

DOCUMENTS INCORPORATED BY REFERENCE

None.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
EXPLANATORY NOTE

The purpose of this Annual Report on Form 10-K/A is to amend Part III, Items 10 through 14 of CNS Pharmaceuticals, Inc.’s (“Company,” “we,” “our,” “us”) Annual Report
on Form 10-K for the year ended December 31, 2020, which was filed with the Securities and Exchange Commission (the “SEC”) on February 12, 2021 and amended on
February 16, 2021 (the “2020 10-K”), to include information previously omitted from the 2020 10-K in reliance on General Instruction G to Form 10-K, which provides that
registrants may incorporate by reference certain information from a definitive proxy statement filed with the SEC within 120 days after the end of the fiscal year. We will not
file our definitive proxy statement before April 30, 2021 (i.e., within 120 days after the end of our 2020 fiscal year) pursuant to Regulation 14A. The reference on the cover of
the Annual Report on Form 10-K to the incorporation by reference of the registrant's definitive proxy statement into Part III of the Annual Report has been deleted.

For purposes of this Annual Report on Form 10-K/A, and in accordance with Rule 12b-15 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), Items
10 through 14 of our 2020 10-K have been amended and restated in their entirety. Except as stated herein, this Form 10-K/A does not reflect events occurring after the filing of
the Form 10-K on February 12, 2021 and no attempt has been made in this Annual Report on Form 10-K/A to modify or update other disclosures as presented in the 2020 10-K.
Accordingly, this Form 10-K/A should be read in conjunction with our filings with the SEC subsequent to the filing of the Form 10-K.

In addition, as required by Rule 12b-15 under the Exchange Act, new certifications by our principal executive officer and principal financial officer are filed as exhibits to this
Annual Report on Form 10-K/A.

1

TABLE OF CONTENTS

PART III

ITEM 10
ITEM 11
ITEM 12
ITEM 13
ITEM 14

PART IV

Directors, Executive Officers and Corporate Governance
Executive Compensation
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
Certain Relationships and Related Transactions, and Director Independence
Principal Accountant Fees and Services

ITEM 15

Exhibits, Financial Statement Schedules

Exhibit Index

ITEM 16

10-K Summary

Signatures

3
6
10
12
13

15

15

17

18

2

 PART III

 Item 10.

Directors, Executive Officers and Corporate Governance

The following table sets forth the names and ages of all of our directors and executive officers as of April 26, 2021. Our officers are appointed by, and serve at the

pleasure of, the Board of Directors.  

Name
John M. Climaco

  Age
52

  Position
  Chairman of the Board and Chief Executive Officer

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Christopher S. Downs
Sandra L. Silberman
Donald Picker
Jerzy (George) Gumulka
Jeffry R. Keyes
Andrzej Andraczke
Carl Evans

43
66
75
72
48
78
74

  Chief Financial Officer
  Chief Medical Officer
  Chief Science Officer
  Director
  Director
  Director
  Director

Set forth below is biographical information about each of the individuals named in the tables above:

John M. Climaco, Esq. – Chief Executive Officer and Director. Mr. Climaco joined CNS in September 2017 as its Chief Executive Officer. Mr. Climaco has served
in leadership roles in a variety of healthcare companies. From April 2015 to June 2017 Mr. Climaco served as the Executive Vice-President of Perma-Fix Medical S.A where he
managed the development of a novel method to produce Technitium-99. Mr. Climaco also served as President and CEO of Axial Biotech, Inc., a DNA diagnostics company,
from January 2003 to January 2013. In the process of taking Axial from inception to product development to commercialization, Mr. Climaco created strategic partnerships with
Medtronic,  Johnson  &  Johnson  and  Smith  &  Nephew.  Mr.  Climaco  currently  serves  as  a  director  of  several  public  companies  including  Moleculin  Biotech,  Inc.,  a
pharmaceutical company focused on anticancer drug candidates, where he has served since May 2017. Mr. Climaco served on the boards of Digirad, Inc., a leading national
provider of imaging services, from May 2012 until April 2020, and Birner Dental Management Services, Inc., a provider of practice management services in the dental industry,
since June 2017. Mr. Climaco also served as a director of PDI, Inc., a provider of outsourced commercial services to pharma companies, in 2015, and InfuSystem Holdings, Inc.,
the largest supplier of infusion services to oncologists in the U.S., from April 2012 to April 2014. Mr. Climaco obtained his Juris Doctorate Degree from the University of
California  Hastings  College  of  Law  in  San  Francisco,  CA  in  January  2000  and  a  Bachelor  of  Philosophy  from  Middlebury  College  in  Middlebury,  VT,  in  May  1991.  Mr.
Climaco is active with the State Bar of Utah. We believe Mr. Climaco’s history with our company, coupled with his vast experience with development stage companies and his
legal background provides him with the qualifications to serve as our chairman of the board.

Christopher S. Downs, CPA – Chief Financial Officer. Mr. Downs has served as our chief financial officer since the closing of our IPO in November 2019. From
March 2018 until September 2019, Mr. Downs served as vice president of finance and treasurer of Innovative Aftermarket Systems, L.P., a privately held provider of finance
and insurance solutions. Mr. Downs served as director of finance (from June 2011 to September 2013), vice president and treasurer (October 2013 to August 2016), executive
vice  president  and  interim  chief  financial  officer  (August  2016  to  May  2017),  and  executive  vice  president,  interim  chief  financial  officer  and  member  of  the  office  of  the
president (May 2017 to March 2018) for InfuSystem Holdings, Inc., a supplier of infusion services to oncologists in the United States. Mr. Downs spent 10 years in investment
banking  with  various  firms  including  Citigroup.  Mr.  Downs  has  also  served  as  a  director  of  Esports  Technologies,  Inc.,  a  technology  company  developing  and  operating
platforms focused on esports and competitive gaming, from March 2021. Mr. Downs is a graduate of the United States Military Academy at West Point where he earned his
Bachelor of Science. Mr. Downs earned his MBA at Columbia Business School and his Master of Science in Accounting at the University of Houston-Clear Lake. Mr. Downs is
a Certified Public Accountant in Utah and Texas.

3

Sandra L. Silberman, MD PhD – Chief Medical Officer. Dr. Silberman joined CNS in December 2017 and currently serves on a part-time basis. Dr. Silberman has
served as chief medical officer for new products of Moleculin Biotech, Inc. since November 2017 on a part-time basis. In 2018, Dr. Silberman became an advisor to WPD
Pharmaceuticals  in  Poland.  Dr.  Silberman  advanced  several  original,  proprietary  compounds  into  Phases  I  through  III  during  her  work  with  leading  biopharmaceutical
companies, including Bristol Myers Squibb, AstraZeneca, Imclone and Roche. Dr. Silberman is a Hematologist/Oncologist who earned her B.A., Sc.M. and Ph.D. from the
Johns Hopkins University School of Arts and Sciences, School of Public Health and School of Medicine, respectively, and her M.D. from Cornell University Medical College,
and then completed both a clinical fellowship in Hematology/Oncology as well as a research fellowship in tumor immunology at the Brigham & Women’ s Hospital and the
Dana Farber Cancer Institute in Boston, MA. Dr. Silberman is currently devoting only 45% of her work time to us and provides services as needed to us.

Donald Picker, PhD - Chief Science Officer. Dr. Picker has served as our part-time chief science officer since June 2019. Dr. Picker has served as the chief scientific
officer of Moleculin Biotech, Inc. since August 2017 after serving as its chief operating officer from July 2015 until August 2017 and as its president from January 2016 to
August 2017. In 2007, Dr. Picker became the chief executive officer of IntertechBio Corp. From 2006 through 2007, Dr. Picker was the President of Tapestry Pharmaceuticals.
From  1998  to  2003,  Dr.  Picker  was  CEO  of  Synergy  Pharmaceuticals.  Synergy  was  merged  into  Callisto  Pharmaceuticals  where  he  was  vice  present  of  research  and
development until 2006. In 2018, Dr. Picker became an advisor to WPD Pharmaceuticals in Poland. From 2017 to 2018, Dr. Picker served on our board of directors. Dr. Picker
received his B.S. degree from Brooklyn Polytechnic University and his PhD from SUNY Albany in 1975. Dr. Picker is currently devoting only 25% of his work time to us and
provides services as needed to us.

Jerzy (George) Gumulka, PhD – Director. Dr. Gumulka joined our board of directors on November 8, 2017. Dr. Gumulka has been retired since 2016. From 2001
until his retirement he served as a Global Technology Manager ASC, a Technology Manager, Special Projects/New Technology Platforms, Kraton Polymers US LLC and a
Technical Director of Kraton Polymers do Brasil. Dr. Gumulka served on the Board of Directors of Moleculin LLC from 2010 through 2016. Dr. Gumulka received a PhD from
the University of Warsaw, Warsaw, Poland. We believe Dr. Gumulka’s technical knowledge and experience in the field of biochemistry coupled with his vast experience in
corporate leadership provides him with the qualifications to serve as a director.

Jeffry R. Keyes – Director. Mr. Keyes joined our board on June 25, 2018. Mr. Keyes is currently the Chief Financial Officer of Custopharm, Inc., a private equity
backed developer of generic sterile injectable pharmaceuticals, a role he has held since April 2018. From September 2012 to April 2018, Mr. Keyes was the Chief Financial
Officer  and  Corporate  Secretary  of  Digirad  Corporation,  a  publicly  traded  healthcare  services  and  medical  device  company.  From August  2011  until  September  2012,  Mr.
Keyes was Corporate Controller of Sapphire Energy, Inc., a venture capital backed start-up renewable energy company. From April 2011 to August 2011, Mr. Keyes was the
Corporate Controller of Advanced BioHealing, Inc., a venture backed provider of regenerative medicine solutions, until its sale to Shire, PLC in August 2011. Prior to April
2011 Mr. Keyes held a variety of leadership roles in healthcare and medical device companies in finance, accounting, and M&A support, and he started his career in public
accounting. Mr. Keyes earned a B.A. degree in accounting from Western Washington University and is a certified public accountant licensed by the Washington State Board of
Accountancy.  Mr.  Keyes  is  considered  a  financial  expert  under  relevant  rules  of  the  SEC,  the  NYSE  and  NASDAQ.  We  believe  Mr.  Keyes’  financial  knowledge  and
experience, which qualify him as an Audit Committee Financial Expert, coupled with his vast experience in corporate leadership provides him with the qualifications to serve as
a director.

Andrzej Andraczke – Director. Mr. Andraczke joined our board on July 9, 2018. Mr. Andraczke is currently Chief Executive Officer of Pol-Tex Holdings, LLC, a role
he has held since November 2012. He is also currently Chief Technology Officer of Syntech LLC (Ireland), a role he has held since November 2017. From March 2016 to April
2016 Mr. Andraczke served as an expert witness for the International Chamber of Commerce for downhole air hammer drilling of the well in volcanic rocks for a geothermal
project in Slovakia. From March 2000 through November 2012 Mr. Andraczke was Vice-President of Pol-Tex Methane. Mr. Andraczke earned a M.Sc. in Engineering from
Warsaw Technical University. We believe Mr. Andraczke’s vast experience in corporate leadership provides him with the qualifications to serve as a director.

4

 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
  
  
 
 
 
 
 
 
 
 
Carl Evans – Director. Mr. Evans joined our board on July 9, 2018. Mr. Evans has been retired since 2015. From 2011 until his retirement Mr. Evans was Executive
Vice President – Exploration for KMD Operating Company, LLC. Prior to 2011, he managed international and domestic oil exploration and production projects for several oil
companies, including British Petroleum, Texaco, and Pennzoil. Mr. Evans earned Bachelor of Science degree in Geology from the University of California, Los Angeles. We
believe Mr. Evan’s vast experience in corporate leadership provides him with the qualifications to serve as a director.

No  director  is  related  to  any  other  director  or  executive  officer  of  our  company  or  our  subsidiaries,  and,  there  are  no  arrangements  or  understandings  between  a

director and any other person pursuant to which such person was elected as director.

Our  Board  of  Directors  has  adopted  a  written  Code  of  Business  Conduct  and  Ethics  applicable  to  all  officers,  directors  and  employees,  which  is  available  on  our
website (www.cnspharma.com) under “Governance Documents” within the “Corporate Governance” section. We intend to satisfy the disclosure requirement under Item 5.05 of
Form 8-K regarding amendment to, or waiver from, a provision of this Code and by posting such information on the website address and location specified above.

Nomination of Director Candidates

We  receive  suggestions  for  potential  director  nominees  from  many  sources,  including  members  of  the  Board,  advisors,  and  stockholders. Any  such  nominations,
together with appropriate biographical information, should be submitted to the Chairperson of the Nominating and Corporate Governance Committee in the manner discussed
below. Any candidates submitted by a stockholder or stockholder group are reviewed and considered in the same manner as all other candidates.

Qualifications  for  consideration  as  a  Board  nominee  may  vary  according  to  the  particular  areas  of  expertise  being  sought  as  a  complement  to  the  existing  board
composition.  However,  minimum  qualifications  include  high  level  leadership  experience  in  business  activities,  breadth  of  knowledge  about  issues  affecting  the  Company,
experience  on  other  boards  of  directors,  preferably  public  company  boards,  and  time  available  for  meetings  and  consultation  on  Company  matters.  Our  Nominating  and
Corporate Governance Committee does not have a formal policy with regard to the consideration of diversity in identifying director candidates, but seeks a diverse group of
candidates  who  possess  the  background,  skills  and  expertise  to  make  a  significant  contribution  to  the  Board,  to  the  Company  and  our  stockholders.  Candidates  whose
evaluations  are  favorable  are  recommended  by  our  Nominating  and  Corporate  Governance  Committee  to  the  full  Board  for  consideration.  The  full  Board  selects  and
recommends candidates for nomination as directors for stockholders to consider and vote upon at the annual meeting.

A stockholder wishing to nominate a candidate for election to our Board of Directors at any annual meeting at which the Board of Directors has determined that one or
more directors will be elected must submit a written notice of his or her nomination of a candidate to the Chairperson of the Nominating and Corporate Governance Committee
(c/o  the  Corporate  Secretary),  providing  the  candidates  name,  biographical  data  and  other  relevant  information  together  with  a  consent  from  the  nominee.  Pursuant  to  our
Bylaws, the submission must be received at our principal executive offices 120 days prior to the anniversary date of the mailing date of our previous year’s proxy statement so
as to permit the Board of Directors time to evaluate the qualifications of the nominee.

We have not employed an executive search firm, or paid a fee to any other third party, to locate qualified candidates for director positions.

Board Committees

We established a Nominating and Corporate Governance Committee, an Audit Committee and a Compensation Committee. Our Board of Directors has adopted and
approved  a  charter  for  each  of  these  standing  committees.  The  charters,  which  include  the  functions  and  responsibilities  of  each  of  the  committees,  can  be  found  in  the
“Investors - Corporate Governance” section on our web site at www.cnspharma.com.

5

Audit Committee. The members of the Audit Committee are Mr. Keyes (Chair), Mr. Andraczke and Mr. Evans. Each member of the Audit Committee is independent
as  defined  by  the  Nasdaq  Rules.  In  addition,  each  member  of  the Audit  Committee  satisfies  the  additional  requirements  of  the  SEC  and  Nasdaq  Rules  for  audit  committee
membership,  including  the  additional  independence  requirements  and  the  financial  literacy  requirements.  The  Board  has  determined  that  at  least  one  member  of  the Audit
Committee, Mr. Keyes, is an “audit committee financial expert” as defined in the SEC’s rules and regulations. The primary purpose of the Audit Committee is to oversee the
quality  and  integrity  of  our  accounting  and  financial  reporting  processes  and  the  audit  of  our  financial  statements.  The  Audit  Committee  is  responsible  for  selecting,
compensating, overseeing and terminating the selection of our independent registered public accounting firm.

Nominating and Corporate Governance Committee. The members of the Nominating and Corporate Governance Committee are Mr. Evans (Chair), Dr. Gumulka, and
Mr. Keyes. Each member of the Nominating and Corporate Governance Committee is independent as defined by Nasdaq Rules. The primary functions and responsibilities of
the Nominating and Corporate Governance Committee are to: (a) determine the qualifications, qualities, skills, and other expertise required to be a director; (b) identify and
screen individuals qualified to become members of the Board; (c) make recommendations to the Board regarding the selection and approval of the nominees for director; and (d)
review and assess the adequacy of our corporate governance policies and procedures.

Compensation Committee. The members of the Compensation Committee are Dr. Gumulka (Chair), Mr. Keyes and Mr. Andraczke. Each member of the Compensation

Committee is independent as defined by Nasdaq Rules.

The Compensation Committee is responsible for, among other things, reviewing and making recommendations to the Board of Directors with respect to the annual
compensation  for  our  Chief  Executive  Officer.  The  Compensation  Committee  also  is  responsible  for  reviewing  and  making  recommendations  to  the  Board  of  Directors  the
annual compensation and benefits for our other executive officers. The Compensation Committee also, among other things, reviews compensation of the Board, reviews and
makes recommendations on all new executive compensation programs that are proposed for adoption and administers the Company’s equity incentive plans. The Compensation
Committee is responsible for reviewing director compensation for service on the Board and Board committees at least once a year and to recommend any changes to the Board.

Our  Chief  Executive  Officer  reviews  the  performance  of  our  other  executive  officers  (other  than  himself)  and,  based  on  that  review,  our  Chief  Executive  Officer
makes recommendations to the Compensation Committee about the compensation of executive officers (other than himself). Our Chief Executive Officer does not participate in
any deliberations or approvals by the Board or the Compensation Committee with respect to his own compensation.

 Item 11.

Executive Compensation

Executive Officer Compensation

Our  named  executive  officers  for  the  years  ended  December  31,  2020  and  2019,  which  consist  of  our  principal  executive  officer  and  our  two  other  most  highly
compensated executive officers, are: (i) John Climaco, our chairman and chief executive officer; (ii) Chris Downs, our chief financial officer; and (ii) Sandra Silberman, our
chief medical officer.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
6

Summary Compensation Table – 2020

Name and Principal Position
John Climaco, Chairman and Chief
Executive Officer

Christopher Downs, Chief Financial
Officer (3)

Sandra Silberman, Chief Medical
Officer

  Year  

  2020  
  2019  

  2020  
  2019  

  2020  
  2019  

Salary
($)

Bonus
($)

Option
awards
($) (1)

Nonequity
incentive plan
compensation
($)

All other
compensation
($) (2)

Total ($)

440,000 
213,867 

300,000 
40,000 

175,000 
23,333 

–     
193,600     

937,808     
806,237     

195,100     
–     

–     
15,600     

1,572,908 
1,229,304 

–     
25,000     

396,299     
1,085,708     

94,700     
–     

–     
3,407     

790,999 
1,154,115 

–     
20,083     

127,058     
229,305     

38,900     
–     

–     
–     

340,958 
272,721 

(1)          Represents the full grant date fair value of the awards calculated in accordance with FASB ASC Topic 718. These amounts do not necessarily correspond to the actual
value that may be realized by the named executive officer. For a summary of the assumptions made in the valuation of the awards, please see Note 5 to our financial statements
as of and for the period ended December 31, 2020 included in our Form 10-K. Option awards for the 2020 calendar year were granted in February 2021.

(2)          Represents reimbursement for health insurance costs.

(3)          Mr. Downs joined our company as chief financial officer in November 2019.

Narrative Disclosure to Summary Compensation Table

We review compensation annually for all employees, including our executives. In setting executive base salaries and bonuses and granting equity incentive awards, we
consider compensation for comparable positions in the market, the individual executive’s performance as compared to our expectations and objectives, our desire to motivate
our employees to achieve short and long-term results that are in the best interests of our stockholders and a long-term commitment to our company. We do not target a specific
competitive  position  or  a  specific  mix  of  compensation  among  base  salary,  bonus  or  long-term  incentives.  Our  Compensation  Committee  typically  reviews  and  discusses
management’s proposed compensation with the Chief Executive Officer for all executives other than the Chief Executive Officer. Based on those discussions and its discretion,
the Compensation Committee then determines the compensation for each executive officer. Our Compensation Committee, without members of management present, discusses
and ultimately approves the compensation of our executive officers.

Annual Base Salary

For the 2021 compensation year, the base salaries for Mr. Climaco, Mr. Downs, and Dr. Silberman are $525,000, $340,000, and $200,000, respectively.

7

Annual Bonus and Non-Equity Incentive Plan Compensation

We seek to motivate and reward our executives for achievements relative to our corporate goals and objectives for each fiscal year. For the 2021 compensation year,

the target bonus for Mr. Climaco, Mr. Downs and Dr. Silberman are 55%, 40%, and 36%, respectively, of their base salary.

The actual performance-based annual bonus paid is calculated by multiplying the executive’s annual base salary, target bonus percentage, the percentage attainment of
the corporate goals established by the Board for such year. However, the Compensation Committee is not required to calculate bonuses in this manner and retains discretion in
the amounts it awards and the factors it takes into consideration in determining bonus amounts. At the end of the year, the Compensation Committee reviews our performance
against our goals and objectives and approves the extent to which we achieved each of our corporate goals and objectives, and, for each named executive officer, the amount of
the bonus awarded.

As  we  completed  our  IPO  in  November  2019,  for  the  2019  compensation  year  we  did  not  establish  formal  goals  and  objectives  at  the  beginning  of  the  year,  and
bonuses were awarded by our Compensation Committee in their discretion for the contributions of management towards our IPO and the pre-clinical work necessary to establish
our supply of Berubicin and preparation for the submission of the Investigative New Drug application to the FDA. These actual bonus amounts are reflected in the "Bonus"
column of the Summary Compensation Table above.

For the 2020 compensation year, bonuses were awarded based on our achievement of specified corporate goals, including the clinical trial progress of Berubicin, our
ability to add additional candidates to our pipeline, and our ability to maintain sufficient funding. Based on the level of achievement, our Compensation Committee awarded
each of our named executive officers approximately 80% of their potential bonuses for 2020. These actual bonus amounts are reflected in the “Non-Equity Incentive Plans”
column of the Summary Compensation Table above.

For the 2021 compensation year, bonuses will be awarded based on our achievement of specified corporate goals, including the clinical trial progress of Berubicin, our

ability to add additional candidates to our pipeline, and our ability to maintain sufficient funding.

Long-Term Incentives

Each year our Compensation Committee establishes a value for the option grant payable to each of our named executive officers. For the 2020 compensation year, the
fair value of the option grants awarded in February 2021 for Mr. Climaco, Mr. Downs and Dr. Silberman were $310,000, $131,000, and $42,000, respectively. We set the option
exercise price, and grant date fair value based on the closing price of our common stock on Nasdaq on the date of grant. The shares underlying options typically vest in four

 
 
 
 
 
 
 
 
 
 
 
   
   
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
      
      
      
      
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
      
      
      
      
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
equal annual installments.

Employment Agreements

John Climaco

On September 1, 2017, we entered into an employment agreement with John Climaco pursuant to which Mr. Climaco agreed to serve as our Chief Executive Officer
commencing on such date for an initial term of three years. On September 1, 2020, we entered into an amendment to the employment agreement. The amendment extends the
term of employment under the employment agreement for additional twelve-month periods, unless and until either the Company or Mr. Climaco provides written notice to the
other party not less than sixty days before such anniversary date that such party is electing not to extend the term. If the Company provides notice of its election not to extend
the term, Mr. Climaco may terminate his employment at any time prior to the expiration of the term by giving written notice to the Company at least thirty days prior to the
effective date of termination, and upon the earlier of such effective date of termination or the expiration of the term, Mr. Climaco shall be entitled to receive the same severance
benefits as are provided upon a termination of employment by the Company without cause. Pursuant to the amendment, the severance benefits shall be twelve months of Mr.
Climaco’s base salary. Such severance payment shall be made in a single lump sum sixty days following the termination, provided that Mr. Climaco has executed and delivered
to the Company, and has not revoked a general release of the Company.

8

Christopher Downs

On September 14, 2019, we entered into an employment agreement with Mr. Christopher Downs pursuant to which Mr. Downs agreed to serve as our Chief Financial
Officer commencing on the closing date of our IPO for an initial term of three years. The agreement provided for an initial annual base salary of $300,000, subject to adjustment
each year. Under the agreement, Mr. Downs was granted a ten-year option to purchase 300,000 shares at an exercise price per share equal to the public offering price per share
of the shares sold in the IPO, or $4.00 per share. The option vests in four equal installments on each of the succeeding four anniversary dates of the option grant, provided Mr.
Downs is employed by us on each such vesting date. If Mr. Downs’ employment is terminated at our election without “cause” (as defined in the agreement), or by Mr. Downs
for “good reason” (as defined in the agreement), Mr. Downs shall be entitled to receive severance payments equal to six months of Mr. Downs’ base salary. Mr. Downs has
agreed not to compete with us until six months after the termination of his employment.

Other Executive Arrangements

On June 28, 2019, our we entered into employment letters with Drs. Silberman and Picker pursuant to which we agreed to the following compensation terms: (i) Dr.
Silberman agreed to commit 50% of her time to our matters in exchange for a base salary, commencing upon the successful closing of the IPO, of $175,000; commencing at the
end of 2019, an annual cash bonus target of 28% of her base salary (prorated for any partial years); and a ten-year option to purchase 125,000 shares of common stock with an
exercise price of $2.00 per share vesting annually in four equal installments; and (ii) Dr. Picker agreed to commit 25% of his time to our matters in exchange for a base salary,
commencing upon the successful closing of the IPO, of $91,000; commencing at the end of 2019, an annual cash bonus target of 36% of his base salary (prorated for any partial
years); and a ten-year option to purchase 100,000 shares of common stock with an exercise price of $2.00 per share vesting annually in four equal installments.

Outstanding Equity Awards

The following table sets forth certain information concerning our outstanding options for our named executive officers on December 31, 2020.

Outstanding Equity Awards At Fiscal Year-End —2020

Name

John Climaco
Christopher Downs
Sandra Silberman

Grant Date of Equity
Award
6/28/2019
11/13/2019
12/22/2017
6/28/2019

Option Awards
Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable (1)

109,875 
75,000 
56,250 
31,250 

Number of
Securities
Underlying
Unexercised
Options (#)

Unexercisable (1)    
329,625   
225,000   
18,750   
93,750   

Option
Exercise
Price
($)

Option
Expiration Date

6/28/2029
11/13/2029
12/22/2027
6/28/2029

2.00   
4.00   
0.045   
2.00   

(1)          The shares underlying the options vest in equal annual installments over a four-year period (i.e., one-quarter of each grant vests on the first, second, third and fourth
anniversary of the grant date).

9

Director Compensation

The following table sets forth the total compensation earned by our non-employee directors in 2020 (Mr. Climaco did not earn additional compensation during 2020

for his services on the Board, and his compensation is fully reflected in the “—Summary Compensation Table” above):

Name

Jerzy (George) Gumulka
Jeffry R. Keyes

Andrzej Andraczke
Carl Evans

Fees earned or 
paid in cash ($)

Option Awards 
($) (1)

Total ($)

  $

  $
  $
  $

46,473    $

61,430    $
44,752    $
46,473    $

99,998    $

99,998    $
99,998    $
99,998    $

146,471 

161,428 
144,750 
146,471 

 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
   
 
 
  
(1) Represents the full grant date fair value of the awards calculated in accordance with FASB ASC Topic 718. These amounts do not necessarily correspond to the actual value
that may be realized by the named executive officer. For a summary of the assumptions made in the valuation of the awards, please see Note 5 to our financial statements as of
and for the period ended December 31, 2020 included in our Form 10-K. As of December 31, 2020, the aggregate number of shares outstanding under all options to purchase
our  common  stock  held  by  our  non-employee  directors  were:  Dr.  Gumulka  –  146,559  shares;  Mr.  Keyes  –  146,559  shares;  Mr. Andraczke  –  146,559  shares;  Mr.  Evans  –
146,559 shares. None of our non-employee directors held stock awards other than options as of December 31, 2020.

In March 2020, our compensation committee recommended to our Board and our Board approved the following policy for compensating non-employee members of
the Board. Each independent director shall receive annual cash compensation of $35,000. In addition, the chairperson of the Audit Committee, Compensation Committee and
Nominating and Governance Committee shall receive an annual compensation of $10,000, $7,000 and $5,000, respectively; the other members of such committees shall receive
an annual compensation of $5,000, $3,500 and $3,000, respectively; and the lead independent director shall receive annual compensation of $10,000. In addition, we agreed to
pay a one-time make-whole payment to the independent directors as follows: (i) Jeff Keyes - $6,554.79; (ii) Jerzy (George) Gumulka - $3,972.60; (iii) Carl Evans - $3,972.60;
and (iv) Andrzej Andraczke - $3,376.71.

 Item 12.

Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

The following table sets forth information, as of April 28, 2021, regarding beneficial ownership of our common stock by:

•                     each of our directors;

•                     each of our executive officers;

•                     all directors and executive officers as a group; and

•                     each person, or group of affiliated persons, known by us to beneficially own more than five percent of our shares of common stock.

10

Beneficial ownership is determined according to the rules of the SEC, and generally means that person has beneficial ownership of a security if he or she possesses sole or
shared voting or investment power of that security and includes options that are currently exercisable or exercisable within 60 days. Each director or officer, as the case may be,
has furnished us with information with respect to beneficial ownership. Except as otherwise indicated, we believe that the beneficial owners of common stock listed below,
based on the information each of them has given to us, have sole investment and voting power with respect to their shares, except where community property laws may apply.
Except as otherwise noted below, the address for each person or entity listed in the table is c/o CNS Pharmaceuticals, Inc., 2100 West Loop South, Suite 900, Houston, TX
77027.

Name and address of beneficial owner

John Climaco
Christopher S. Downs
Sandra Silberman
Donald Picker
Jerzy (George) Gumulka
Jeffry R. Keyes
Andrzej Andraczke
Carl Evans
Directors and Officers as a group
5% or greater shareholders
Waldemar Priebe

*            Less than 1%.

Shares beneficially
owned

Percentage of Class (1)

1,119,750
217,000
118,750 (2)
150,000 (2)
146,559 (2)
146,559 (2)
146,559 (2)
146,559 (2)
2,191,736

9,029,000 (3)

4.4%
*
*
*
*
*
*
*
8.6%

35.6%

(1)      Based on 25,359,059 shares of common stock outstanding as of April 28, 2021.

(2)      Consists solely of options exercisable within 60 days of April 28, 2021.

(3)      Of the amount in the table, 200,000 shares are held by Houston Pharmaceuticals, Inc. Dr. Priebe has voting and dispositive power over the shares held by Houston
Pharmaceuticals, Inc.

Securities Authorized for Issuance under Equity Compensation Plans 

The following table sets forth information regarding our equity compensation plans at December 31, 2020:

Plan category
​Equity compensation plans approved by security holders (1)
Equity compensation plans not approved by security holders (2)

Number of
securities to be
issued upon
exercise of
outstanding
options,
warrants and
rights
(a)

Weighted-average
exercise price of
outstanding options,
warrants and rights
(b)

Number of
securities (by class)
remaining
available for future
issuance under
equity
compensation
plans (excluding
securities reflected
in column (a))
(c)

2,200,736   
326,500   

$
$

2.00   
2.81   

2,799,264 
– 

(1)      Represents shares of common stock issuable upon exercise of outstanding stock options and rights under our 2017 and 2020 Stock Plans.

(2)      Consists of warrants issued to the underwriter in our IPO and follow-on offering and to consultants.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
  
 
 
 
 
   
   
 
 
 
 
 
 
 
 
 
11

 Item 13.

Certain Relationships and Related Transactions, and Director Independence

On  December  28,  2017,  we  obtained  the  rights  to  a  worldwide,  exclusive  royalty-bearing,  license  to  the  chemical  compound  commonly  known  as  Berubicin  from
Houston  Pharmaceuticals,  Inc.  (“HPI”)  in  an  agreement  we  refer  to  as  the  HPI  License.  Dr.  Priebe  controls  HPI.  Under  the  HPI  License  we  obtained  the  exclusive  right  to
develop certain patented chemical compounds for use in the treatment of cancer anywhere in the world. Our rights pursuant to the HPI License are contingent on us raising at
least $7,000,000 within 12 months from the effective date of the HPI License, a date which can be extended by an additional 12 months by the payment of a nominal fee. In the
HPI License we agreed to pay HPI: (i) development fees of $750,000 over a three-year period beginning after the $7.0 million raise is complete; (ii) a 2% royalty on net sales;
(iii)  a  $50,000  per  year  license  fee;  (iv)  milestone  payments  of  $100,000  upon  the  commencement  of  a  Phase  II  trial  and  $1.0  million  upon  the  approval  of  an  NDA  for
Berubicin; and (v) 200,000 shares of our common stock. Unrelated to this agreement we purchased $385,000 of pharmaceutical products from HPI for use in our clinical trials.

On August 30, 2018, we entered into a sublicense agreement with WPD Pharmaceuticals, Inc., or WPD, pursuant to which we granted WPD an exclusive sublicense,
even  as  to  us,  for  the  patent  rights  we  licensed  pursuant  to  the  HPI  License  within  the  following  countries:  Poland,  Estonia,  Latvia,  Lithuania,  Belarus,  Ukraine,  Moldova,
Romania,  Bulgaria,  Serbia,  Macedonia,  Albania,  Armenia,  Azerbaijan,  Georgia,  Montenegro,  Bosnia,  Croatia,  Slovenia,  Slovakia,  Czech  Republic,  Hungary,  Chechnya,
Uzbekistan, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, Greece, Austria, and Russia. The sublicense agreement provides that WPD must use commercially reasonable
development efforts to attempt to develop and commercialize licensed products in the above mentioned territories, which means the expenditure of at least $2.0 million on the
development,  testing,  regulatory  approval  or  commercialization  of  the  licensed  products  during  the  three  year  period  immediately  following  the  date  of  the  sublicense
agreement.  In  the  event  that  WPD  fails  to  use  commercially  reasonable  development  efforts  to  by  the  foregoing  three-year  deadline,  we  have  the  right  to  terminate  this
sublicense agreement. In consideration for the rights granted under the sublicense agreement, to the extent we are required to make any payments to HPI pursuant to the HPI
License as a result of this sublicense agreement, WPD agreed to advance us such payments, and to pay us a royalty equal to 1% of such payments. WPD is a Polish corporation
that is majority-owned by an entity controlled by Dr. Priebe.

On August 31, 2018, we entered into a sublicense agreement with Animal Life Sciences, LLC, or ALI, pursuant to which we granted ALI an exclusive sublicense, even
as  to  us,  for  the  patent  rights  we  licensed  pursuant  to  the  HPI  License  solely  for  the  treatment  of  cancer  in  non-human  animals  through  any  type  of  administration.  In
consideration for the rights granted under the sublicense agreement, ALI agreed to issue us membership interests in ALI equal to 1.52% of the outstanding ALI membership
interests. As additional consideration for the rights granted, to the extent we are required to make any payments to HPI pursuant to the HPI License as a result of this sublicense
agreement, ALI agreed to advance us such payments, and to pay us a royalty equal to 1% of such payments. Dr. Priebe holds 38% of the membership interests of ALI.

On January 29, 2019, we entered into a consulting agreement with WPD. The agreement is for a period of one year, with compensation of $5,000 per month. The
consulting  services  include  the  full-time  services  of  a  technical  researcher  currently  employed  by  WPD.  We  paid  $30,000  for  the  first  six  months  upon  execution  of  the
agreement.

On  March  20,  2020,  we  entered  into  a  development  agreement  with  WPD,  a  company  founded  by  Dr.  Priebe.  Pursuant  to  the  agreement,  WPD  agreed  to  use  its
commercially reasonable efforts in good faith to develop and commercialize certain products that WPD had previously sublicensed, solely in the field of pharmaceutical drug
products for the treatment of any viral infection in humans, with a goal of eventual approval of in certain territories consisting of: Germany, Poland, Estonia, Latvia, Lithuania,
Belarus,  Ukraine,  Romania,  Armenia,  Azerbaijan,  Georgia,  Slovakia,  Czech  Republic,  Hungary,  Uzbekistan,  Kazakhstan,  Greece,  Austria,  Russia,  Netherlands,  Turkey,
Belgium,  Switzerland,  Sweden,  Portugal,  Norway,  Denmark,  Ireland,  Finland,  Luxembourg,  Iceland.  Pursuant  to  the  agreement,  we  agreed  to  pay  WPD  the  following
payments: (i) an upfront payment of $225,000 to WPD; and (ii) within thirty days of the verified achievement of the Phase II Milestone, (such verification shall be conducted by
an independent third party mutually acceptable to the parties hereto), we will make a payment of $775,000 to WPD. WPD agreed to pay a development fee of 50% of the net
sales for any products in the above territories; provided that Poland shall not be included as a territory after WPD receives marketing approval for a product in one-half of the
countries included in the agreed upon territories or upon the payment by WPD to us of development fees of $1.0 million. The term of the agreement will expire on the expiration
of the sublicense pursuant to which WPD has originally sublicensed the products.

12

On February 19, 2021, CNS entered into a Investigational Medicinal Product Supply Agreement with WPD. CNS agreed to sell Berubicin drug product to WPD at
historical cost of manufacturing without markup so that WPD may conduct the clinical trials contemplated by the sublicense agreement.WPD agreed to pay CNS the following
payments:  (i)  an  upfront  payment  of  $131,072.42  upon  execution  of  the  agreement,  (ii),  a  payment  of  $262,144.85  upon  final  batch  release  and  certification  performed  by
WPD's subcontractor, and (iii) a final payment of $262,144.85 upon Clinical Trial Application acceptance by the relevant regulatory authority.

Policies and Procedures for Related Party Transactions

Our audit committee charter provides that our audit committee is responsible for reviewing and approving in advance any related party transaction. This will cover,
with certain exceptions  set  forth  in  Item  404  of  Regulation  S-K  under  the  Securities Act,  any  transaction,  arrangement  or  relationship,  or  any  series  of  similar  transactions,
arrangements or relationships in which we were or are to be a participant, where the amount involved exceeds $120,000 and a related person had or will have a direct or indirect
material  interest,  including,  without  limitation,  purchases  of  goods  or  services  by  or  from  the  related  person  or  entities  in  which  the  related  person  has  a  material  interest,
indebtedness,  guarantees  of  indebtedness  and  employment  by  us  of  a  related  person.  In  determining  whether  to  approve  a  proposed  transaction,  our Audit  Committee  will
consider all relevant facts and circumstances including: (i) the materiality and character of the related party’s direct or indirect interest; (ii) the commercial reasonableness of the
terms; (iii) the benefit or perceived benefit, or lack thereof, to us; (iv) the opportunity cost of alternate transactions; and (v) the actual or apparent conflict of interest of the
related party.

Director Independence

The rules of the Nasdaq Stock Market, or the Nasdaq Rules, require a majority of a listed company’s board of directors to be composed of independent directors. In
addition, the Nasdaq Rules require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and governance committees be
independent.  Under  the  Nasdaq  Rules,  a  director  will  only  qualify  as  an  independent  director  if,  in  the  opinion  of  our  Board  of  Directors,  that  person  does  not  have  a
relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. The Nasdaq Rules also require that audit committee
members  satisfy  independence  criteria  set  forth  in  Rule  10A-3  under  the  Securities  Exchange Act  of  1934,  as  amended,  or  the  Exchange Act.  In  order  to  be  considered
independent for purposes of Rule 10A-3, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the
board  of  directors,  or  any  other  board  committee,  accept,  directly  or  indirectly,  any  consulting,  advisory,  or  other  compensatory  fee  from  the  listed  company  or  any  of  its
subsidiaries or otherwise be an affiliated person of the listed company or any of its subsidiaries. In considering the independence of compensation committee members, the
Nasdaq  Rules  require  that  our  board  of  directors  must  consider  additional  factors  relevant  to  the  duties  of  a  compensation  committee  member,  including  the  source  of  any
compensation we pay to the director and any affiliations with our company.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Our  board  of  directors  undertook  a  review  of  the  composition  of  our  board  of  directors  and  its  committees  and  the  independence  of  each  director.  Based  upon
information requested from and provided by each director concerning his background, employment and affiliations, including family relationships, our board of directors has
determined that each of our directors, with the exception of Mr. Climaco, are independent as defined under the Nasdaq Rules.

 Item 14.

Principal Accounting Fees and Services

Aggregate fees for professional services rendered by MaloneBailey, LLP for their services for the fiscal years ended December 31, 2019 and 2020, respectively, were as follows:

Audit Fees
Audit-related fees
Tax fees
All other fees
TOTAL

Audit Fees

2019

2020

25,000   
19,000   
0   
22,600   
66,600   

$

$

48,000 
3,000 
0 
0 
51,000 

$

$

13

Audit fees represent the aggregate fees billed for professional services rendered by our independent accounting firm for the audit of our annual financial statements, review of
financial statements included in our quarterly reports, review of registration statements or services that are normally provided in connection with statutory and regulatory filings
or engagements for those fiscal years.

Audit-Related Fees

Audit-related fees represent the aggregate fees billed for assurance and related services that are reasonably related to the performance of the audit or review of our financial
statements and are not reported under Audit Fees.

Tax Fees

Tax fees represent the aggregate fees billed for professional services rendered by our principal accountants for tax compliance, tax advice, and tax planning for such years.

All Other Fees

All other fees represent the aggregate fees billed for products and services other than the services reported in the other categories.

Audit Committee Pre-Approval Policies and Procedures

The Audit Committee on an annual basis reviews audit and non-audit services performed by the independent auditors. All audit and non-audit services are pre-approved by the
Audit Committee, which considers, among other things, the possible effect of the performance of such services on the auditors’ independence.

14

 PART IV

 Item 15.

Exhibits, Financial Statement Schedules

(a)       The following documents are filed or furnished as part of this Form 10-K:

1.       Financial Statements. Reference is made to the Index to Financial Statements under Item 8, Part II hereof.

2.       Financial Statement Schedules. The Financial Statement Schedules have been omitted either because they are not required or because the information has

been included in the financial statements or the notes thereto included in this Annual Report on Form 10-K.

3.       Exhibits

Exhibit
Number

3.1

3.2

 EXHIBIT INDEX

Description of Document

Amended and Restated Articles of Incorporation of CNS Pharmaceuticals, Inc. (filed as exhibit 2.1 to the Company’s Form 1-A file no. 024-10855)

Amended and Restated Bylaws of CNS Pharmaceuticals, Inc.  (filed as exhibit 2.2 to the Company’s Form 1-A file no. 024-10855)

 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
4.1

4.2

4.3 #

10.1

10.2

10.3 **

10.4 **

10.5 **

10.6

10.7

10.8 **

10.9 **

10.10 **

10.11 +

Form of warrant issued to convertible debt holders (filed as exhibit 3.2 to the Company’s Form 1-A file no. 024-10855)

Form of Underwriter Warrant (filed as exhibit 4.4 to the Company’s Form 1-A Amendment file no. 024-10855)

Description of Securities of CNS Pharmaceuticals, Inc.

15

Amended And Restated Patent License Agreement effective as of December 28, 2017 between CNS Pharmaceuticals, Inc. and Houston Pharmaceuticals, Inc.
(filed as exhibit 6.1 to the Company’s Form 1-A file no. 024-10855)

Collaboration and Asset Purchase Agreement between CNS Pharmaceuticals, Inc. and Reata Pharmaceuticals, Inc. dated November 21, 2017 (filed as exhibit
6.2 to the Company’s Form 1-A file no. 024-10855)

2017 Stock Plan of CNS Pharmaceuticals, Inc.  (filed as exhibit 6.3 to the Company’s Form 1-A file no. 024-10855)

Employment Agreement between CNS Pharmaceuticals, Inc. and John M. Climaco dated September 1, 2017 (filed as exhibit 6.4 to the Company’s Form 1-A
file no. 024-10855)

Consulting Agreement between CNS Pharmaceuticals, Inc. and Fresh Notion Financial Services dated July 27, 2017 (filed as exhibit 6.5 to the Company’s Form
1-A file no. 024-10855)

Sublicense Agreement between CNS Pharmaceuticals, Inc. and WPD Pharmaceuticals, Inc. dated August 30, 2018 (filed as exhibit 6.6 to the Company’s Form
1-A Amendment file no. 024-10855)

Sublicense Agreement between CNS Pharmaceuticals, Inc. and Animal Life Sciences, LLC. dated August 31, 2018 (filed as exhibit 6.7 to the Company’s Form
1-A Amendment file no. 024-10855)

Employment Letter between CNS Pharmaceuticals, Inc. and Donald Picker (filed as exhibit 10.8 to the Company’s Form 1-A Amendment file no. 024-10855)

Employment Letter between CNS Pharmaceuticals, Inc. and Sandra Silberman (filed as exhibit 10.9 to the Company’s Form 1-A Amendment file no. 024-
10855)

Employment Agreement between CNS Pharmaceuticals, Inc. and Christopher Downs (filed as exhibit 10.10 to the Company’s Form 1-A Amendment file no.
024-10855)

Patent and Technology License Agreement with The Board of Regents of The University of Texas System, an agency of the State of Texas, on behalf of The
University of Texas M. D. Anderson Cancer Center, dated January 10, 2020 (filed as exhibit 10.11 to the Company’s Form 10-K filed March 12, 2020)

10.12 **

Non-Employee Director Compensation Plan (filed as exhibit 10.12 to the Company’s Form 10-K filed March 12, 2020)

10.13

Development Agreement between CNS Pharmaceuticals, Inc. and WPD Pharmaceuticals dated March 20, 2020 (filed as exhibit 10.1 to the Company’s Form 8-
K filed March 26, 2020)

10.14 **

2020 Stock Plan of CNS Pharmaceuticals, Inc. (filed as exhibit 99.2 to the Company’s Form S-8, file no. 333-239998, filed on July 22, 2020

16

10.15**

Amendment to Employment Agreement between CNS Pharmaceuticals, Inc. and John Climaco dated September 1, 2020 (filed as exhibit 99.1 to the Company’s
Form 8-K filed September 4, 2020)

10.16

10.17

23.1

31.1 #

31.2 #

32.1 #

32.2 #

Purchase Agreement, dated as of September 15, 2020, by and between the Company and Lincoln Park Capital Fund, LLC (filed as exhibit 10.1 to the
Company’s Form 8-K filed September 21, 2020)

Registration Rights Agreement, dated as of September 15, 2020, by and between the Company and Lincoln Park Capital Fund, LLC (filed as exhibit 10.2 to the
Company’s Form 8-K filed September 21, 2020)

Consent of MaloneBailey LLP

Certification of Principal Executive Officer pursuant to Rule 13a-14 of the Securities Exchange Act of 1934, as amended

Certification of Principal Financial Officer pursuant to Rule 13a-14 of the Securities Exchange Act of 1934, as amended

Certification of Principal Executive Officer Pursuant to Section 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Certification of Principal Financial Officer Pursuant to Section 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
101.INS *
101.SCH *
101.CAL *
101.DEF *
101.LAB *
101.PRE *

XBRL Instance Document
XBRL Taxonomy Extension Schema Document
XBRL Taxonomy Extension Calculation Linkbase Document
XBRL Taxonomy Extension Definition Linkbase Document
XBRL Taxonomy Extension Label Linkbase Document
XBRL Taxonomy Extension Presentation Linkbase Document

#
*
**
+

Filed herewith.
Previously filed with the Original Filing.
Management contract or compensatory plan, contract or arrangement.
Pursuant to Item 601(b)(10)(iv) of Regulation S-K promulgated by the SEC, certain portions of this exhibit have been redacted. The Company hereby agrees to furnish
supplementally to the SEC, upon its request, an unredacted copy of this exhibit.

  Item 16.

10-K Summary

None.

17

 SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the

undersigned, thereunto duly authorized

CNS PHARMACEUTICALS, INC.

Date: April 30, 2021

By:

/s/ John Climaco
John Climaco
Chief Executive Officer and Director

(Principal Executive Officer)

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the Registrant and in the

capacity and on the dates indicated.

Date: April 30, 2021

Date: April 30, 2021

Date: April 30, 2021

Date: April 30, 2021

Date: April 30, 2021

Date: April 30, 2021

By:

/s/ John Climaco
John Climaco
Chief Executive Officer, President and Director

(Principal Executive Officer)

/s/ Christopher Downs
Christopher Downs
Chief Financial Officer

(Principal Financial and Accounting Officer)

/s/ Jerzy (George) Gumulka
Jerzy (George) Gumulka
Director

/s/ Carl Evans
Carl Evans
Director

/s/ Jeffry Keyes
Jeffry Keyes
Director

/s/ Andrzej Andraczke
Andrzej Andraczke
Director

18

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DESCRIPTION OF THE COMPANY’S SECURITIES

EXHIBIT 4.3

The following summary is a description of the material terms of our capital stock. This summary is not complete, and is qualified by reference to our amended and
restated articles of incorporation, and our amended and restated bylaws, which are filed as exhibits to this Annual Report on Form 10-K and are incorporated by reference
herein. We encourage you to read our amended and restated articles of incorporation, our amended and restated bylaws and the applicable provisions of the Nevada Revised
Statutes for additional information.

Our amended and restated articles of incorporation authorize us to issue up to 75,000,000 shares of common stock and 5,000,000 shares of preferred stock.

Common Stock

Shares of our common stock have the following rights, preferences and privileges:

Voting

Each holder of common stock is entitled to one vote for each share of common stock held on all matters submitted to a vote of stockholders. Any action at a meeting at
which a quorum is present will be decided by a majority of the voting power present in person or represented by proxy, except in the case of any election of directors, which will
be decided by a plurality of votes cast. There is no cumulative voting.

Dividends

Holders of our common stock are entitled to receive dividends when, as and if declared by our board of directors out of funds legally available for payment, subject to
the rights of holders, if any, of any class of stock having preference over the common stock. Any decision to pay dividends on our common stock will be at the discretion of our
board of directors. Our board of directors may or may not determine to declare dividends in the future. See “Dividend Policy.” The board’s determination to issue dividends will
depend upon our profitability and financial condition any contractual restrictions, restrictions imposed by applicable law and the SEC, and other factors that our board of
directors deems relevant.

Liquidation Rights

In the event of a voluntary or involuntary liquidation, dissolution or winding up of the Company, the holders of our common stock will be entitled to share ratably on

the basis of the number of shares held in any of the assets available for distribution after we have paid in full, or provided for payment of, all of our debts and after the holders of
all outstanding series of any class of stock have preference over the common stock, if any, have received their liquidation preferences in full.

Other

Our issued and outstanding shares of common stock are fully paid and nonassessable. Holders of shares of our common stock are not entitled to preemptive rights.

Shares of our common stock are not convertible into shares of any other class of capital stock, nor are they subject to any redemption or sinking fund provisions.

1

Preferred Stock

We are authorized to issue up to 5,000,000 shares of preferred stock. Our articles of incorporation authorizes the board to issue these shares in one or more series, to

determine the designations and the powers, preferences and relative, participating, optional or other special rights and the qualifications, limitations and restrictions thereof,
including the dividend rights, conversion or exchange rights, voting rights (including the number of votes per share), redemption rights and terms, liquidation preferences,
sinking fund provisions and the number of shares constituting the series. Our board of directors could, without stockholder approval, issue preferred stock with voting and other
rights that could adversely affect the voting power and other rights of the holders of common stock and which could have the effect of making it more difficult for a third party
to acquire, or of discouraging a third party from attempting to acquire, a majority of our outstanding voting stock.

Warrants

December 2018 Warrants

In August and September 2017, we issued an aggregate of $86,825 in principal amount of convertible notes (the “2017 Notes”), at conversion prices ranging from
$0.001 to $0.045 per share. The note holders also collectively received in the aggregate warrants to purchase 1,206,059 shares of our common stock at an exercise price of
$11.00 per share. On December 31, 2018, the Company amended the 2017 convertible notes to allow the notes to be converted prior to the Company’s IPO at the holder’s
option. Certain debtholders then exercised their right to convert the outstanding principal and accrued interest of their outstanding notes on December 31, 2018. A total of
$38,670 of outstanding principal and $3,128 of accrued interest was converted into 2,158,500 shares of common stock. Additionally, certain note holders entered into settlement
agreements to extinguish their remaining principal balance of $48,155 and remaining accrued interest of $8,434 in exchange for 2,454,071 warrants to purchase common stock
at an exercise price of $0.70 per share for a term of five years. The December 31, 2018 amendment, conversion and settlement was accounted for as an extinguishment and a
loss on extinguishment of $6,286,841 was recognized. As of December 31, 2018, none of the 2017 Notes remained outstanding.

December 2020 Warrants

In December 2020, we issued warrants to purchase 2,875,000 shares of common stock in a registered public offering.

The warrants are exercisable, at the option of each holder, in whole or in part, by delivering to us a duly executed exercise notice accompanied by payment in full in

immediately available funds for the number of shares of our common stock purchased upon such exercise (except in the case of a cashless exercise as described below). A
holder (together with its affiliates) may not exercise any portion of the warrant to the extent that the holder would own more than 4.99% (or, at the election of the holder,
9.99%) of the outstanding common stock immediately after exercise, except that upon at least 61 days’ prior notice from the holder to us, the holder may increase the amount of
ownership of outstanding stock after exercising the holder’s warrants up to 9.99% of the number of shares of our common stock outstanding immediately after giving effect to
the exercise, as such percentage ownership is determined in accordance with the terms of the warrants. Purchasers of warrants could have also elected prior to the issuance of
the warrants to have the initial exercise limitation set at 9.99% of our outstanding common stock. No fractional shares of common stock will be issued in connection with the
exercise of a warrant. In lieu of fractional shares, we will pay the holder an amount in cash equal to the fractional amount multiplied by the exercise price.

The exercise price per whole share of our common stock purchasable upon the exercise of the warrants is $2.20 per share of common stock. The warrants are

immediately exercisable and may be exercised at any time up to the date that is five years after their original issuance. The exercise price of the warrants is subject to
appropriate adjustment in the event of certain stock dividends and distributions, stock splits, stock combinations, reclassifications or similar events affecting our common stock

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
and also upon any distributions of assets, including cash, stock or other property to our stockholders.

2

If, at any time after the issuance of the warrants, a holder of the warrants exercises the warrants and a registration statement registering the issuance of the shares of

common stock underlying the warrants under the Securities Act is not then effective or available (or a prospectus is not available for the resale of shares of common stock
underlying the warrants), then in lieu of making the cash payment otherwise contemplated to be made to us upon such exercise in payment of the aggregate exercise price, the
holder shall instead receive upon such exercise (either in whole or in part) only the net number of shares of common stock determined according to a formula set forth in the
warrants. Notwithstanding anything to the contrary, in the event we do not have or maintain an effective registration statement, there are no circumstances that would require us
to make any cash payments or net cash settle the warrants to the holders.

Subject to applicable laws, the warrants may be offered for sale, sold, transferred or assigned at the option of the holder upon surrender of the warrant to us together

with the appropriate instruments of transfer.

In the event of a fundamental transaction, as described in the warrants and generally including any reorganization, recapitalization or reclassification of our common

stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more
than 50% of our outstanding common stock, or any person or group becoming the beneficial owner of 50% of the voting power represented by our outstanding common stock,
the holders of the warrants will be entitled to receive upon exercise of the warrants the kind and amount of securities, cash or other property that the holders would have
received had they exercised the warrants immediately prior to such fundamental transaction.

Except by virtue of such holder’s ownership of shares of our common stock, the holder of a warrant does not have the rights or privileges of a holder of our common

stock, including any voting rights, until the holder exercises the warrant.

Articles of Incorporation and Bylaw Provisions

Our articles of incorporation and bylaws include a number of anti-takeover provisions that may have the effect of encouraging persons considering unsolicited tender

offers or other unilateral takeover proposals to negotiate with our board of directors rather than pursue non-negotiated takeover attempts. These provisions include:

Advance Notice Requirements. Our bylaws establish advance notice procedures with regard to stockholder proposals relating to the nomination of candidates for

election as directors or new business to be brought before meetings of stockholders. These procedures provide that notice of stockholder proposals must be timely and given in
writing to our corporate Secretary. Generally, to be timely, notice must be received at our principal executive offices not fewer than 120 calendar days prior to the first
anniversary date on which our notice of meeting and related proxy statement were mailed to stockholders in connection with the previous year’s annual meeting of stockholders.
The notice must contain the information required by the bylaws, including information regarding the proposal and the proponent.

Special Meetings of Stockholders. Our bylaws provide that special meetings of stockholders may be called at any time by only the Chairman of the Board, the Chief

Executive Officer, the President or the board of directors, or in their absence or disability, by any vice president.

No Written Consent of Stockholders. Our articles of incorporation and bylaws provide that any action required or permitted to be taken by stockholders must be

effected at a duly called annual or special meeting of stockholders and may not be effected by any consent in writing by such stockholders. 

Amendment of Bylaws. Our stockholders may amend any provisions of our bylaws by obtaining the affirmative vote of the holders of a majority of each class of issued

and outstanding shares of our voting securities, at a meeting called for the purpose of amending and/or restating our bylaws.

Preferred Stock. Our articles of incorporation authorizes our board of directors to create and issue rights entitling our stockholders to purchase shares of our stock or
other securities. The ability of our board to establish the rights and issue substantial amounts of preferred stock without the need for stockholder approval may delay or deter a
change in control of us. See “Preferred Stock” above.

3

Nevada Takeover Statute

The Nevada Revised Statutes contain provisions governing the acquisition of a controlling interest in certain Nevada corporations. Nevada’s “acquisition of controlling

interest” statutes (NRS 78.378 through 78.3793, inclusive) contain provisions governing the acquisition of a controlling interest in certain Nevada corporations. These “control
share” laws provide generally that any person that acquires a “controlling interest” in certain Nevada corporations may be denied voting rights, unless a majority of the
disinterested stockholders of the corporation elects to restore such voting rights. These laws will apply to us if we were to have 200 or more stockholders of record (at least 100
of whom have addresses in Nevada appearing on our stock ledger) and do business in the State of Nevada directly or through an affiliated corporation, unless our articles of
incorporation or bylaws in effect on the tenth day after the acquisition of a controlling interest provide otherwise. These laws provide that a person acquires a “controlling
interest” whenever a person acquires shares of a subject corporation that, but for the application of these provisions of the NRS, would enable that person to exercise (1) one-
fifth or more, but less than one-third, (2) one-third or more, but less than a majority or (3) a majority or more, of all of the voting power of the corporation in the election of
directors. Once an acquirer crosses one of these thresholds, shares which it acquired in the transaction taking it over the threshold and within the 90 days immediately preceding
the date when the acquiring person acquired or offered to acquire a controlling interest become “control shares” to which the voting restrictions described above apply. These
laws may have a chilling effect on certain transactions if our amended and restated articles of incorporation or amended and restated bylaws are not amended to provide that
these provisions do not apply to us or to an acquisition of a controlling interest, or if our disinterested stockholders do not confer voting rights in the control shares.

Nevada’s “combinations with interested stockholders” statutes (NRS 78.411 through 78.444, inclusive) provide that specified types of business “combinations”
between certain Nevada corporations and any person deemed to be an “interested stockholder” of the corporation are prohibited for two years after such person first becomes an
“interested stockholder” unless the corporation’s board of directors approves the combination (or the transaction by which such person becomes an “interested stockholder”) in
advance, or unless the combination is approved by the board of directors and 60% of the corporation’s voting power not beneficially owned by the interested stockholder, its
affiliates and associates. Furthermore, in the absence of prior approval certain restrictions may apply even after such two-year period. For purposes of these statutes, an
“interested stockholder” is any person who is (1) the beneficial owner, directly or indirectly, of 10% or more of the voting power of the outstanding voting shares of the
corporation, or (2) an affiliate or associate of the corporation and at any time within the two previous years was the beneficial owner, directly or indirectly, of 10% or more of
the voting power of the then-outstanding shares of the corporation. The definition of the term “combination” is sufficiently broad to cover most significant transactions between
a corporation and an “interested stockholder”. These laws generally apply to Nevada corporations with 200 or more stockholders of record. However, a Nevada corporation
may elect in its articles of incorporation not to be governed by these particular laws, but if such election is not made in the corporation’s original articles of incorporation, the
amendment (1) must be approved by the affirmative vote of the holders of stock representing a majority of the outstanding voting power of the corporation not beneficially

 
 
 
 
 
 
 
 
 
 
  
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
owned by interested stockholders or their affiliates and associates, and (2) is not effective until 18 months after the vote approving the amendment and does not apply to any
combination with a person who first became an interested stockholder on or before the effective date of the amendment. We have not made such an election in our original
articles of incorporation or in our amended and restated articles of incorporation.

Limitations on Liability and Indemnification of Officers and Directors

Our articles of incorporation and bylaws limit the liability of our officers and directors and provide that we will indemnify our officers and directors, in each case, to

the fullest extent permitted by the Nevada Revised Statutes.

Listing

Our common stock is listed on the Nasdaq Capital Market under the symbol “CNSP”.

Transfer Agent

The transfer agent for our common stock is Continental Stock Transfer and Trust.

4

  
 
 
 
 
 
  
 
 
 
 
 
CERTIFICATION BY OFFICER

EXHIBIT 31.1

I, John Climaco, certify that:

1.

I have reviewed this Form 10-K/A for the year ended December 31, 2020 of CNS Pharmaceuticals, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of

the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

Date: April 30, 2021

By:

/s/    John Climaco
John Climaco
Chief Executive Officer and President

 
 
 
 
 
 
 
 
 
 
 
 
 
 
I, Christopher Downs, certify that:

1.

I have reviewed this Form 10-K/A for the year ended December 31, 2020 of CNS Pharmaceuticals, Inc.;

CERTIFICATION BY OFFICER

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of

the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

Date: April 30, 2021

By:

/s/ Christopher Downs
Christopher Downs
Chief Financial Officer

EXHIBIT 31.2

 
 
 
 
 
 
 
 
 
 
 
 
CERTIFICATION OF OFFICER

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)

EXHIBIT 32.1

Pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), the undersigned officer

of CNS Pharmaceuticals, Inc., a Nevada corporation (the “Company”), does hereby certify, to such officer’s knowledge, that:

The Form 10-K/A for the year ended December 31, 2020 (the “Report”) of the Company fully complies with the requirements of section 13(a) or 15(d) of the
Securities Exchange Act of 1934, as amended, and information contained in the Report fairly presents, in all material respects, the financial condition and results of operations
of the Company.

Date: April 30, 2021

By:

/s/    John Climaco
John Climaco
Chief Executive Officer and President

 
 
 
 
 
 
 
 
 
 
 
 
 
 
CERTIFICATION OF OFFICER

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)

EXHIBIT 32.2

Pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), the undersigned officer

of CNS Pharmaceuticals, Inc., a Nevada corporation (the “Company”), does hereby certify, to such officer’s knowledge, that:

The Form 10-K/A for the year ended December 31, 2020 (the “Report”) of the Company fully complies with the requirements of section 13(a) or 15(d) of the
Securities Exchange Act of 1934, as amended, and information contained in the Report fairly presents, in all material respects, the financial condition and results of operations
of the Company.

Date: April 30, 2021

By:

/s/ Christopher Downs
Christopher Downs
Chief Financial Officer