GSK
Annual Report 2023

Plain-text annual report

At GSK, we unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. Contents Strategic report Ahead Together 2023 performance and key performance indicators Chair’s statement CEO’s statement Business model Our external environment Prevention Our culture and people Research and development Commercial operations: Performance: Vaccines Performance: Specialty Medicines Performance: General Medicines Operations: Manufacturing and supply Responsible business Risk management and disclosure statements 2023 principal risks summary Climate-related financial disclosures Nature-related financial disclosures Non-financial and sustainability information statement Employees by gender Viability statement Group financial review 01 02 04 06 08 10 13 14 16 31 33 37 40 43 45 57 59 62 70 75 75 76 77 Investor information Financial record Product development pipeline Products, competition and intellectual property Principal risks and uncertainties Share capital and control Dividends Financial calendar 2024 Annual General Meeting 2024 Tax information for shareholders Shareholder services and contacts US law and regulation Group companies Glossary of terms 273 277 281 284 295 297 298 298 299 301 303 306 315 Corporate governance The Board and GSK Leadership Team Chair’s governance statement Corporate governance architecture Ahead Together – Board oversight Continuous engagements and key decisions Board committee reports Remuneration Committee Chair’s annual statement Annual report on remuneration Directors’ report Financial statements Directors’ statement of responsibilities Independent auditor’s report Financial statements Notes to the financial statements Financial statements of GSK plc prepared under UK GAAP 108 114 116 119 121 128 139 142 161 164 166 180 184 267 Cautionary statement See the inside back cover of this document for the cautionary statement regarding forward-looking statements. Non-IFRS measures We use a number of adjusted, non-International Financial Reporting Standards (IFRS) measures to report the performance of our business. Total reported results represent the Group’s overall performance under IFRS. Adjusted results and other non-IFRS measures may be considered in addition to, but not as a substitute for or superior to, information presented in accordance with IFRS. Adjusted results and other non-IFRS measures are defined on pages 82 and 83 and reconciliations to the nearest IFRS measures are on pages 93 to 95. Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 We are a focused biopharma company with strong momentum and big ambitions. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our Ahead Together strategy means intervening early to prevent and change the course of disease, helping to protect people and support healthcare systems. We’re confident in our future. With our strong momentum and improving outlook for sustained growth through the decade, we're confident in our ability to deliver human health impact at scale, worldwide. We’re committed to getting ahead of issues that matter for society and for the sustainability of our company, too – including access to healthcare, diversity, equity and inclusion, and the health of our planet. We're sector leaders in ESG performance, making an impact on some of society’s most urgent challenges. Our purpose puts our people at the heart of our success. Core to our Ahead Together ambition is to make GSK a place where talented people thrive. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for our patients, shareholders and GSK people. 1 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 2023 performance and key performance indicators Financial We delivered strong performance and upgraded our growth outlooks. Broad-based performance drove sales, profits and earnings growth. Group turnover (£bn) Turnover by product area (£bn) £30.3bn AER 3% CER 5% 2023 growth excluding COVID-19 solutions 12% AER 14% CER l Vaccines £9.9bn AER 24% CER 25% l Specialty Medicines £10.2bn AER (9)% CER (8)% l General Medicines £10.2bn AER 1% CER 5% Total operating profit (£bn) Adjusted operating profit (£bn) £6.7bn AER 5% CER 10% £8.8bn AER 8%1 CER 12%1 2023 growth excluding COVID-19 solutions 12% AER 16% CER Total continuing earnings per share (p) Adjusted earnings per share (p) 121.6p AER 10% CER 16% 155.1p AER 11%2 CER 16%2 2023 growth excluding COVID-19 solutions 16% AER 22% CER Cash generated from operations (£bn) Free cash flow (£bn) £8.1bn £3.4bn We use a number of adjusted, non-IFRS, measures to report the performance of our business. Adjusted results and other non-IFRS measures may be considered in addition to, but not as a substitute for or superior to, information presented in accordance with IFRS. Adjusted results and other non-IFRS measures are defined on pages 82 and 83. AER – actual exchange rate; CER – constant exchange rate. Excluding COVID-19 solutions as defined on page 85. (1) Adjusted operating profit +12% (with further positive impact of +4% excluding COVID-19 solutions) at CER. (2) Adjusted EPS +16% (with further positive impact of +6% excluding COVID-19 solutions) at CER. Key performance indicator attributable to continuing operations Linked to executive remuneration. See pages 142 to 149 for more details 2 24.729.330.32021202220234.46.46.72021202220236.58.28.820212022202382.9p110.8p121.6p202120222023110.3p139.7p155.1p2021202220237.27.98.12021202220233.33.33.4202120222023 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 2023 performance and key performance indicators continued Research and development We continued to strengthen the late-stage pipeline with organic R&D delivery and targeted business development, supporting future growth. £10bn innovation sales of products launched or with major lifecycle innovation expansion in the last five years 4 18 major approvals including in infectious diseases, HIV and oncology assets in phase III/registration 71 6 12 assets in the pipeline major business development deals at least 12 major product launches planned from 20251 Pipeline value and progress are not reported externally because of their commercial sensitivity. Responsible business We continue to be recognised for our environmental and sustainability leadership. Our ESG Performance Rating is on track based on 95% of all performance metrics being met or exceeded. The metrics cover our six focus areas: access to healthcare, global health and health security, environment , diversity, equity and inclusion , ethical standards, and product governance (see pages 45 to 55). 1st 11 10% in the pharmaceuticals industry in the S&P Global Corporate Sustainability Assessment, with a score of 84 (as of 24 November 2023) Global Health pipeline assets progressed to address priority World Health Organization (WHO) diseases reduction in operational carbon emissions (Scope 1 and 2) Culture Culture progress – ambitious for patients, accountable for impact and do the right thing – is measured through our employee surveys. Our employee engagement score remained high at 81% in 2023. + Read more on page 14 (1) Planned launches of products with non-risk adjusted peak year sales of >=£2 billion. See 'Guidance and outlooks, assumptions and basis of preparation related to 2024 guidance, 2021-26 and 2031 outlooks' on inside back cover and FY 2023 results slides on gsk.com. 3 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Chair's statement In 2023 GSK continued to make significant progress on its strategic transformation. The programme of change Emma and her team are delivering is fundamentally improving GSK’s competitiveness: sharpening operational execution and cost discipline; strengthening the pipeline; enhancing the Group’s capital allocation capacity; and shifting GSK’s culture to combine high integrity with performance. As is also clear from this report, GSK is developing a distinctive role and voice in prevention of disease, offering clear benefits to patients, healthcare systems and wider society. Strategic progress In 2023, we saw further evidence of the success of this transformation. Operationally, GSK is performing better – and crucially more consistently and competitively – than at any point in the last 20 years. Group sales and operating profits grew strongly in 2023 and well ahead of the outlooks for more than 5 and 10% CAGR (excluding COVID-19 solutions) previously set for the period to 2026. GSK’s progress and momentum is such that we have now upgraded these outlooks to more than 7 and 11%1 respectively. Growth is being driven by very strong performance across all areas of the business, especially Vaccines and Specialty Medicines, including in HIV and respiratory, where the company has built significant leadership positions and competitive advantage. The exceptional launch of the world’s first RSV vaccine, Arexvy, in the US was a clear stand out achievement for the year. Cost discipline across the Group continues to improve. Following a period of necessary investment in product launches, management is now focused on delivering further improvements in operating margin over the coming years. As I have previously discussed, the demerger of Haleon in 2022 fundamentally reset and strengthened GSK’s balance sheet. During 2023 we monetised £1.8 billion of our holding in Haleon to enable further investment in the pipeline and the future growth of the company. We have also confirmed our commitment to shareholder returns through a progressive dividend policy. The Board agreed to pay shareholders an increased dividend of 58p per share for 2023, up 3p per share2 on a comparable basis. R&D progress Executing the company’s late-stage pipeline and strengthening our earlier- stage R&D and technological capabilities, remains the company’s number one priority. This continues to receive significant attention from the Board, including through our Science Committee, which undertook detailed reviews during 2023 of several research areas, including vaccines & RNA technology, antimicrobial resistance (AMR). oligonucleotides, antibody-drug conjugates (ADCs) and liver disease (NASH). Improving R&D productivity is inevitably a long-term programme. But I was pleased to see good progress made during the year, both organically and through targeted business development. In total we deployed approximately £2 billion to R&D business development, including acquisitions and partnerships during the year. As Emma sets out in her letter on pages 6 to 7, GSK now has significant and potentially very valuable late- stage R&D programmes in vaccines/ infectious diseases, HIV, respiratory and specific areas of oncology. Successful progression of these programmes is vital to support the Group’s growth outlook in the second half of the decade and beyond. (1) See 'Guidance and outlooks, assumptions and basis of preparation related to 2024 guidance, 2021-26 and 2031 outlooks' on the inside back cover and FY 2023 results slides on gsk.com (2) GSK group dividend in 2022 was 55p, this is GSK related only and excludes the dividend related to Consumer Healthcare in H1 2022. 4 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 I was also pleased to welcome Julie Brown as Chief Financial Officer (CFO) in May last year. Julie brings huge experience in life sciences and as a CFO of large UK-based companies. The GSK Board now has excellent, in many cases world-leading, experience and expertise including in human genetics, vaccines, respiratory and infectious disease; advanced technologies including in AI and ML; biopharma commercial and financial expertise and US payer, HCP and patient understanding. GSK is performing better than it has done for many years and has an increasingly positive outlook, and this is due to the energy, commitment and leadership of Emma and her team in support of the company’s ambitious programme of change. Finally, I would also like to thank all of our people, partners, customers and shareholders for their support and commitment through the last year and I look forward to another year of progress in 2024 for GSK. Sir Jonathan Symonds Chair Chair's statement continued Culture and responsibility I believe that one of the strongest drivers of GSK’s long-term performance is the culture shift that Emma and her team are driving. We are seeing significant change here, with the focus on developing a clear purpose, strengthening leadership, and embedding business-relevant values and behaviours. Ensuring environmental, social and governance considerations are also properly embedded into our strategy remains very important. I was delighted to see the company ranked first in the sector in S&P’s 2023 assessment of Corporate Sustainability. GSK also continues to lead in our approach to ensuring global access to our products and in developing new medicines and vaccines for diseases such as malaria and TB which disproportionately affect the poorest countries in the world. 2023 was also the second year of operation of our new remuneration policy. This is designed to support achievement of outperformance across strategic, financial and ESG goals, and I believe it is helping to drive the strong performance culture and deep commitment to responsibility that is evident at GSK. Shareholder returns The Board remains focused on delivering strong shareholder returns and valuation for GSK over the long term. It is clear from the extensive meetings and discussions I have had with shareholders over the year, that they recognise the significant performance improvements that have been delivered. Emphasis has now moved from the shorter-term outlooks to 2026, to the medium term to 2031. The upgraded outlooks we have given for both periods show the confidence of the Board and Management in GSK’s future. The uncertainty around Zantac (ranitidine) litigation has clearly impacted GSK’s share price performance over the 18 months. We continue to vigorously defend ourselves against the remaining claims in the US, including the ongoing proceedings in Delaware and hope to see greater clarity on the litigation during 2024. Board evolution The composition and maturity of the Board continues to improve to ensure we have the relevant skills and experience to provide good oversight and support, and constructively challenge management as GSK’s business develops as a pure biopharma company. I was pleased to welcome Wendy Becker to the Board in October. Wendy is a highly experienced non-executive director and brings excellent business, technology and life sciences experience. She will also succeed Urs Rohner as Chair of the Remuneration Committee when he steps down at the May 2024 AGM. I would like to thank Urs for his contribution to the GSK Board, particularly the development of our new remuneration policy, approved in 2022, to incentivise and reward management performance. He has been a consistent and determined supporter of GSK and has provided huge support to Emma and I. 5 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 CEO’s statement GSK is delivering on its commitments and performing to a new standard. The excellent performance we delivered in 2023 provides us with clear momentum and we expect to deliver another year of meaningful growth in 2024, as we continue to focus on prevention and changing the course of disease. Delivering on our commitments In 2021, we set out a series of commitments to shareholders, including for a 'step-change' in performance, following the significant transformation in GSK’s structure, strategy, capital allocation and culture. Since then, we have delivered 10 quarters of consecutive sales growth (excluding COVID-19 solutions), and around two-thirds of sales are now generated from Vaccines and Specialty Medicines, a key strategic priority. At the same time, we have continued to strengthen our pipeline. We now have 71 vaccines and medicines in clinical development and the majority of the late-stage assets we highlighted in 2021 have moved forward positively. Since 2021, we have also added multiple new opportunities through targeted business development, securing more than 16 acquisitions and alliances for innovative assets and new technologies. We have achieved all of this whilst maintaining a continued sharp focus on operating margins and cash flow – mindful of the need to both invest for the future and to deliver attractive returns to shareholders. Strong 2023 performance As set out on pages 2 to 3, our performance for 2023 demonstrated this progress, with sales excluding COVID-19 solutions and both total and adjusted profits growing at double- digit levels at CER. A clear highlight for the year was the exceptional launch of Arexvy, the world’s first vaccine for RSV, which contributed £1.2 billion of sales in its first year. More than 10% of American adults aged 60 years and older have now been vaccinated against RSV, and over two-thirds of those have been vaccinated with Arexvy. Over time we expect Arexvy to generate annual sales of more than £3 billion and 2024 sales to be driven by further penetration, initial roll out of the vaccine in Europe and Japan and expansion of Arexvy’s indication to at risk individuals aged 50-59 years. Our shingles vaccine, Shingrix, also delivered another very strong performance in 2023, with £3.4 billion of sales. In Specialty Medicines, our HIV business grew strongly, up 13% CER, driven by acceleration in our oral two-drug and long-acting injectable regimens for treatment and prevention. We also saw good progress in respiratory with our market-leading IL-5, Nucala, up 18% CER. Lupus treatment Benlysta was also a major contributor up 19% CER. Overall, sales from new products launched since 2017 contributed more than £11 billion. This level of performance helped us to generate free cash flow of £3.4 billion. As a consequence of this performance and momentum, we were also pleased to increase the dividend for the year to 58 pence per share. Pipeline strengthening In R&D, we continued to make progress in 2023 both organically and through business development, as set out on pages 16 to 30. We delivered four major product approvals during the year: Arexvy; Apretude in HIV prevention; Ojjarra for myelofibrosis and Jemperli in first-line endometrial cancer. With 18 assets now in phase III or registrational studies, we are looking forward to further significant late- stage R&D milestones in 2024. 6 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 CEO's statement continued Targeted business development also continued to strengthen the pipeline and support future growth. Our activity in 2023 included the acquisition of Bellus Health and Aiolos Bio1, which both further strengthen our respiratory pipeline, and the signing of licence agreements with Janssen and Hansoh Pharma, in infectious diseases and oncology. Upgrading our outlooks In 2024, we expect another year of meaningful growth of sales, adjusted operating profit and EPS. We have also upgraded the outlooks we previously gave for the period 2021-2026, and 2031.2 This is all because of the progress we have made to develop our portfolio and pipeline. Alongside our current growth drivers, we are now planning for at least 12 major product launches from 2025, most of which will be in the next four years. This includes new potential vaccines for meningitis, influenza, pneumococcal disease and herpes simplex virus (HSV); potential medicines for long-acting HIV treatment and prevention; a potential functional cure for hepatitis B, bepirovirsen; and a new portfolio of potential anti-infective treatments, including gepotidacin. We also have potential new medicines for respiratory diseases with high burden and unmet need: depemokimab and camlipixant. And finally, in oncology, we have further potential indications for Jemperli and potentially CD226 targeting a variety of cancer types. Our upgraded outlook for 2021-2026 is for sales to grow more than 7% and adjusted profit by more than 11%, on a CAGR basis. And by 2031, we now believe we can deliver more than £38 billion of sales. This is an increase of £5 billion versus the estimate we gave in 2021 of more than £33 billion, and represents a marked acceleration as, in effect, we now expect to reach our original 2031 goal by 2026, five years earlier. We will continue to focus strongly on margin improvements, while retaining flexibility to invest in growth. And we will keep working to deliver more, as it is important to emphasise that none of our forecasts include anticipated business development, further progress in our early-stage pipeline, or additional productivity improvements. All of that points to a strong outlook for GSK with sustained growth through the decade. Building trust We are committed to making GSK a place where talented people can thrive, with a culture where we are all ambitious for patients, accountable for impact and do the right thing. It was very positive that engagement scores remain high, at 81%, in our latest employee engagement survey. Operating responsibly remains core to GSK. We aim to continue delivering sector-leading ESG performance, as recognised in our latest ranking as sector leaders of the S&P’s Global Corporate Sustainability Assessment. This reflects strong progress across our six core ESG areas: Access to healthcare, Global health and health security, Environment, Diversity, Equity and Inclusion, Ethical standards and Product governance. We have long-term goals and key metrics in place for all these areas, and our overall performance rating for 2023 was ‘on track,’ based on 95% of metrics being met or exceeded. Highlights for the year included, moving to phase III development for our low-carbon Ventolin inhaler programme, achieving our leadership diversity aspirations two years early, and Gavi confirming the roll out of our malaria vaccine, Mosquirix, in up to 12 countries in Africa. Further details are set out on pages 45 to 55 and in our published standalone ESG Performance Report. Clear momentum as we look ahead In conclusion, GSK has strong momentum and improving outlooks. As a standalone biopharma company, with expertise in developing innovative vaccines and medicines, we have enormous opportunity to prevent and change the course of disease for hundreds of millions of people. All of this bodes well. Equally, we also know there is much to be done. We remain very focused on delivering this potential – and more – at continued pace for patients, for shareholders and for our people. Finally, as ever, it is our people who fuel this momentum and I want to thank them for all they have achieved during 2023. I am very optimistic for the future and excited by what we can achieve, to get ahead of disease, together. Emma Walmsley Chief Executive Officer (1) Closed in early 2024. (2) See 'Guidance and outlooks, assumptions and basis of preparation related to 2024 guidance, 2021-26 and 2031 outlooks' on the inside back cover and FY 2023 results slides on gsk.com 7 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Business model We unite science, technology and talent to get ahead of disease together for health impact, shareholder returns and thriving people. Central to our success are our people: experts in science, technology, manufacturing, regulation, intellectual property and commercialisation... 70,200 >75 GSK people countries worldwide £6.2bn R&D investment in 2023 – up 13% AER, 14% CER1 37 manufacturing sites 22,000 suppliers working directly with GSK 4 global R&D centres in the US, UK, Belgium and Italy ...who are identifying, researching, developing and testing ground-breaking discoveries, and manufacturing and commercialising... Vaccines Our broad vaccines portfolio targets infectious diseases at every stage of life, helping to protect people from meningitis, shingles, RSV, flu, polio and many more. Specialty Medicines Our specialty medicines prevent and treat diseases, from HIV and respiratory diseases, to immune- inflammation diseases like lupus, to cancer. Many are first or best-in-class. General Medicines We have a portfolio of more than 150 primary care medicines, including our inhaled medicines for asthma and COPD, and antibiotics for infections. ...products that prevent and treat disease, improving the health of millions of people around the world in our core therapeutic areas... Infectious diseases Our infectious diseases portfolio is the broadest in the industry and, including HIV, accounts for two thirds of our pipeline. HIV We are leaders in HIV, focused on ending the global epidemic. We have an industry-leading pipeline, driven by patient insights. Respiratory/ immunology We’re pushing the frontiers of respiratory science and harnessing the science of the immune system to transform patient outcomes in areas of unmet need, based on decades of innovative research. Oncology We have an emerging portfolio focused on blood and women's cancers, and are seeking to make transformative breakthroughs in immuno-oncology. (1) Total R&D expenditure includes intangible asset amortisation and impairments plus immaterial amounts of major restructuring and other costs. 8 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Business model continued ...powered by technology... Pipeline We are leveraging new platform and data technology at every step of the R&D process to be faster, more effective, and more predictive in discovering and developing innovative new medicines and vaccines. Performance We use technology to enable more productive and efficient manufacturing processes, supply chain reliability and returns on investment. People and productivity Technology is also core to how we work. We ensure our people have the tools, analytical capabilities and resources to make data-driven decisions and do their best work. ...steered by our long-term priorities... Innovation We develop and launch new medicines and vaccines where they are needed, with better and faster R&D. Performance Our bold ambitions for patients are reflected in our upgraded growth outlooks to 2026 and 2031. ...and creating value for: Patients 2.3bn packs of medicines and doses of vaccines delivered Shareholders 58p per share dividend Trust We focus on issues where we can have the greatest impact and reduce pressure on health systems including tackling health challenges and inequities, protecting the environment and taking action on diversity, equity and inclusion. Society £1.3bn corporate income tax paid; in addition we pay duties, levies, transactional and employment taxes The economy Disease prevention and earlier intervention to improve health can lessen pressure on health systems and support economic productivity. Our people We support all our people to grow, be well and do work that really matters. Reinvestment The returns we make enable us to reinvest in discovering and developing new vaccines and medicines so we can continue getting ahead of disease. Company directors are required by law to promote the success of their organisation for the benefit of both shareholders and their wider stakeholders, including employees, suppliers and the community. Information on the issues, factors and stakeholders that the Board considers relevant to complying with Section 172 (a) to (f) of the Companies Act 2006 is in the Section 172 statement of the Corporate governance section on page 123. + Our business model is supported by our ESG strategy, described on page 46 + Our strategy is supported by a robust framework for monitoring and managing risk, see page 57 9 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Our external environment Five major themes influenced our external environment in 2023. Here, we set out what they mean for us and how we are responding. Economic growth shows resilience but pressure continues on public finances The global economy proved to be more resilient than expected in 2023. But the recovery remained relatively fragile and uneven, with prospects diverging between regions. Many countries continued to grapple with persistent inflation, driven by factors including tight labour markets. Several major central banks responded by increasing interest rates, adding to the burden of rising costs for consumers and businesses. Despite sticky inflation and a consequent tightening of monetary policy, the global economy continued to expand, albeit at a slower rate. There were notable pockets of strength. America’s economy grew in 2023, buoyed by sustained consumer spending and robust government spending associated with infrastructure investment legislation passed in 2021 and 2022. But this resilience was not always mirrored elsewhere. For example, forecasts for the eurozone were revised downwards, as the region continued to feel the impact of weaker demand and higher costs. Amid rising levels of debt and political volatility, global growth prospects remain tepid. Public spending – including on health – remains under strain. Governments face unprecedented pressure on their finances due to a string of economic shocks, sustained sluggish growth and higher debt. Higher interest rates are now making it more challenging to service those debts. This is compelling governments to make tough choices about where to direct spending. 3% Global growth was forecast to slow to 3% in 2023.1 >25% In August 2023, six further countries were invited to join the BRICS group. The combined economies of an enlarged group would be worth more than $28.5 trillion – more than a quarter of the world's economy.2 Geopolitical tensions fuel shifting alliances Fragmentation and regionalisation continued to grow in 2023, with ongoing conflicts in Ukraine and the Middle East focusing ever more attention on political alliances. Tensions between China and the US remained, with new export controls and investment screening mechanisms emerging on both sides, particularly focused on critical minerals, AI, semiconductors and biotechnologies. But there were signs of relations improving between the two nations, with their presidents meeting for the first time in a year on the sidelines of the Asia-Pacific Economic Cooperation summit. New alliances also emerged, potentially shifting the weight and influence of various blocs. A summit in August saw the BRICS group of countries widen its membership, for the first time since 2010, inviting six further countries, including Saudi Arabia and Iran, to join. As countries look to diversify and de- risk their supply chains in strategic sectors including biopharmaceuticals, many are looking towards India as an alternative supplier to China. Yet against this backdrop, activity in China's biopharmaceutical sector is resilient, recognising the acceleration of Chinese innovation and growth potential. More low and middle-income countries capitalised on global policy forums, such as the UN General Assembly, to set the agenda on issues related to health, new technologies and industrial development. With more diverse voices on global platforms, inequality is seen as a critical issue where governments must collectively make progress. In healthcare, there are debates around the best measure of widening access, with attention on equitable distribution of the infrastructure, capability and know- how to make health products, while protecting intellectual property rights and efficient supply chains. (1) https://www.imf.org/en/Blogs/Articles/2023/10/10/resilient-global-economy-still-limping-along-with-growing-divergences. (2) https://www.bbc.co.uk/news/world-66525474 10 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Our external environment continued Changing demographics create opportunity for innovation and prevention Pressures on health systems continued into 2023 amid ongoing efforts to recover and rebuild in the aftermath of the COVID-19 pandemic. Populations are ageing, bringing more complex health needs. Chronic diseases are taking an increasing toll while infectious diseases remain a significant threat. The individual impact of changing demographics and disease patterns extends to societies and economies at large. Poor health is a significant drag on economic growth. Every year, poor health costs around 15% of global real GDP from premature deaths and lost productive potential among working age people1. In the UK alone, 131 million working days are estimated to be lost each year due to illness.2 Despite the potential to improve individual outcomes and boost economic productivity through investing in health, particularly through prevention and earlier intervention, governments continued to look for cost savings in health systems. The US progressed implementation of the Inflation Reduction Act (IRA). This included selecting the first 10 drugs for potential price cuts under a new programme enabling Medicare to negotiate the price of some of the costliest medicines. While this could potentially limit future innovation and access to currently available medicines, the IRA does bring meaningful benefits to certain Medicare patients, such as access to vaccines without having to bear part of the cost. The EU also took forward legislation that could test pharmaceutical innovation and competitiveness. Meanwhile, the UK agreed a five-year deal aimed at reducing medicine costs for the NHS by setting an annual limit on the allowed growth in sales value of branded medicines. Even as governments sought ways to cut medicine costs, they continued to look to the biopharma industry to be a driver of innovation and economic growth, with the US President's State of the Union address underlining an appetite for more and better treatments, particularly in cancer. This highlights the potential for the biopharma industry to be a partner in recovery, harnessing science and technology to provide solutions that help prevent and change the course of disease and bring value to individuals, health systems and societies. 1.6bn Societies are ageing, bringing different health challenges. The number of people aged 65 years or older worldwide is projected to more than double, rising from 761 million in 2021 to 1.6 billion in 2050.3 Balancing potential of tech and data with appropriate use Rapid advances in science and technology continue to shape the life sciences sector and R&D. Established technologies such as small molecules and vaccines remain key. Emerging technologies, such as MAPS and DNA/RNA therapeutics, including oligonucleotides, are gaining ground and building market share. Major biopharma companies continue to increase their focus on artificial intelligence and machine learning (AI/ ML) to accelerate drug discovery. Progress hinges on diverse patient data being available for computational research, in particular genomic data, linked to health information held in clinical records. Revolutions in data and technological capabilities open up new possibilities for patients through advances in drug discovery, as well as enhancing manufacturing and supply of medicines. But the possibilities for improving health outcomes need to be balanced with appropriate regulation that supports innovation and ensures responsible use by those who develop the technology, as well as those who use and apply it. During the year, the debate around regulation of AI gathered pace as governments stepped up their efforts to examine the technology’s promise and risks. In the first legislation of its kind, the EU passed the AI Act in June 2023, taking a stringent approach that does not consider context-specific use of AI in healthcare. The US and the UK continue to consider how to place appropriate guardrails around the use of AI, while supporting innovation and considering implications for specific sectors. At a landmark summit in November 2023, the UK, EU, US, Australia and China all agreed to work together on AI safety research. $45bn In the last five years, biopharma has entered into collaborations with AI companies which are estimated to be worth more than $45 billion.4 (1) www.mckinsey.com/industries/healthcare/our-insights/how-prioritizing-health-could-help-rebuild-economies (2) www.cbi.org.uk/media-centre/articles/boosting-workforce-health-can-help-the-uk-achieve-economic-growth-ambitions-says-cbi/ (3) www.un.org/development/desa/dspd/wp-content/uploads/sites/22/2023/01/WSR_2023_Chapter_Key_Messages.pdf - Chapter Key Messages_WSR 2023 (un.org) (4) www.accenture.com/content/dam/accenture/final/accenture-com/document-2/Accenture-Tech_Vision_Biopharma_Accenture-Merging %20atoms%20and%20bits%20in%20Life%20Sciences_V14.pdf 11 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Our external environment continued Pressure increasing on climate and nature action Economic pressures and political realignments are influencing how countries approach global challenges that need collective action, including climate change and nature loss. The Intergovernmental Panel on Climate Change issued a 'final warning' in March 2023 to keep the 1.5°C degrees target within reach,1 setting out the urgency for sufficient and swift climate action. Some regions see the need for climate action as an opportunity to use green policies as a lever for growth. For example, the European Commission set out a Green Deal industrial plan to make Europe a centre for clean technology and innovation. But as policy makers tackled rising inflation and increased living costs, climate targets came under pressure. The UK softened its net zero policies and EU environment ministers did not increase their target for reducing greenhouse gas emissions, after opposition from some member countries. At the international climate conference COP28 in Dubai, countries committed to transition away from fossil fuels and to triple renewable energy capacity. It also saw the climate-health agenda given more prominence than ever before, with 123 governments endorsing the COP28 Declaration on Climate and Health. Companies continue to take action to reduce their climate impact and protect their business model, taking steps to ensure their products and supply chains remain resilient to the consequences of climate change. Scientific evidence of the link between climate change and human health means we continue to see high expectations of the healthcare sector to both reduce carbon emissions and respond to the health impacts of climate change. During the year, biopharma companies stepped up their commitments, including to strengthen locally led adaptation and health resilience programmes for vulnerable communities affected by climate change. There's also a growing focus on limiting nature loss. The Taskforce on Nature-related Financial Disclosures released its final recommendations in 2023, providing a risk management and disclosure framework for organisations to report and act on evolving nature-related risks. See the Responsible Business section on page 45 and Nature-related Financial Disclosures on page 62. 100 In further evidence of a growing investor interest in nature, ‘Nature Action 100’ aims to mobilise institutional investors to establish a common agenda for corporate action on nature. It will focus on eight sectors, including biotechnology and pharmaceuticals. Our position In a challenging economic and political landscape, it's critical that we invest in a pipeline of vaccines and medicines that prevent and change the course of disease, to meet changing and unmet healthcare needs. At the same time, we have to work with governments, regulators and industry partners to make sure these medicines and vaccines can reach patients at scale, bringing value to both the people who need them and to payers. Scientific innovation is a critical lever to improve health, boost productivity and economic growth, and ease the strain on health systems. We continue to work with our peers and governments to make sure that the policy and regulatory environment stimulates and sustains innovation. (1) https://sciencebasedtargets.org/blog/ ipcc-releases-final-warning-to-keep-1-5- c-within-reach This includes, for example, advocating for appropriate IP protections; a balanced regulatory framework that supports the discovery and delivery of vaccines and medicines developed through emerging technologies; and reinforcing the importance of global, diversified supply chains. As the pricing environment becomes tougher, we believe we’re well placed to offer a differentiated, high-value pipeline across prevention and treatment of disease. This is built on using transformational new technology and techniques to make our R&D faster and smarter. Demand for data and real-world evidence to support continued reimbursement of new products is likely to increase. We continue to work with payers to design innovative solutions that manage their risk and uncertainty, while also recognising the full health, social and economic value of innovative medicines and vaccines. Populations are ageing, infectious diseases are still spreading and chronic diseases are taking a greater toll. All of this is creating unsustainable pressure on health systems. More than ever, we believe that getting ahead of disease is the best investment – for patients, carers, communities, health systems and economies. We’ll continue to work with governments, payers and partners to move towards new models of care that enable earlier action to prevent, diagnose and treat disease. Together, we have an opportunity to rethink health – not just to treat sickness, but to invest in keeping people well. For more on why and how prevention underpins our purpose to get ahead of disease, see page 13 12 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 At GSK, we believe prevention is the best medicine Prevention is at the heart of getting ahead of disease – preventing ill health in the first place and stopping disease in its tracks. Why is prevention important? Health systems are stretched and health needs are evolving as demographics and disease patterns change. >3 million premature deaths among people under 75 could have been avoided through better prevention and healthcare interventions across OECD countries in 2019. This amounts to over a quarter of all deaths. (source: OECD) $1 trillion loss in productivity each year in the G20 from preventable conditions among people aged 50-64. (source: ilcuk) $7 trillion In the US alone, health spending is projected to reach almost $7 trillion by 2030. (source: CMS) Prevention and earlier intervention offer a solution to these challenges, helping to improve people's health outcomes – and bring benefits to health systems and economies. $12 trillion could be added to global GDP by 2040 by improving health. Around half of the annual economic benefits would come from a larger and healthier workforce. (source: McKinsey) What does prevention mean to us? Preventing and changing the course of disease is at the heart of what we mean by getting ahead of disease together. By harnessing our science and technology, we have an opportunity to prevent disease in the first place, as well as change the course of a disease – helping to prevent or slow progression of an illness and limit long-term complications. Prevention is a focus across our pipeline and portfolio including: Vaccines We’ve built one of the broadest vaccine portfolios in the industry to help protect people at all stages of life, from childhood to older age. With our wide range of vaccine technologies like MAPS, mRNA and adjuvants, we can take a targeted approach, allowing us to develop tailored vaccines for different diseases and individuals – see page 18. HIV For decades, we’ve transformed the lives of people living with HIV by making breakthroughs in treatment and prevention. We’re focusing research on novel treatment options that allow people living with HIV to take fewer drugs or take them much less often, and we’ve also developed a long-acting regimen that can prevent HIV – see page 22. Severe asthma Our decades of experience in respiratory care have led us to create treatments that could bring patients closer than ever before to remission for severe asthma. This could free them from exacerbations (attacks) that cause cumulative lung damage and could potentially avoid hospitalisation – removing the need for oral corticosteroids, stabilising lung function and controlling symptoms – see page 23. Hepatitis B Using the latest AI/ML techniques, our scientists have identified biomarkers to help work out which treatment combinations fit which patients. This potentially increases the likelihood of achieving 'functional cure' – when the virus is no longer present in the blood, and liver functions have normalised, stopping any future damage – see page 19. We believe that preventing and getting ahead of disease is the best investment for everyone – for patients, carers, communities, health systems and economies. We want to work with patients, policy makers and our peers to stop disease in its tracks, creating the right conditions to champion prevention and enable timely, proactive access to preventative interventions. 13 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Our culture and people Our purpose – to unite science, technology and talent to get Ahead of disease Together – puts our people at the heart of our success. Digital and technology remain core to our purpose and delivery of our ambitions. We have built our people's skills in this area with global events such as DataCon, where all employees can experience immersive sessions to see first- hand how to apply digital, data and tech tools including generative AI to become more digitally fluent. This year, more than 7,000 employees took part from every business unit and 28 countries. In our Data Academy, employees can access resources and online training. We've run programmes to develop our senior leaders' leadership skills in the digital age. We've also piloted a career hub using AI to match employees with mentors, projects and potential job opportunities. We will scale this up in 2024. In 2023, we enhanced our onboarding experience for new joiners by introducing monthly live virtual sessions with our CEO and other senior leaders. By having access to senior global leaders from the beginning of their career with us, we aim to provide a more intimate connection to GSK and the patients we serve, creating emotional connection with our purpose, strategy and culture, to complement ongoing local onboarding activities. Supporting our people managers Our people managers play a crucial role in helping their teams to thrive and connecting the contributions the team makes to the patient and GSK's broader impact. We expect people managers to motivate, focus, care for and develop their teams and we deliver training anchored in these four areas. In 2023 all of our VPs were invited to attend a four day in-person event called Leading Leaders, a programme to help leaders bring out the best in their teams and foster the culture we need to succeed together. We also continue to invest in growing the next generation of senior leaders to support our talent and succession needs through bespoke development interventions, equipping them with leadership skills for the future. Our culture We are committed to making GSK a place where people can thrive, with a culture where we are all ambitious for patients, accountable for impact, and do the right thing. This means we support our people to do things better and faster, focusing on what matters most. It means setting clear objectives, creating accountability for results and giving everyone the support and space they need to succeed. It means doing everything responsibly with integrity and care, because people and patients around the world count on us. Our culture is embedded in everything we do from our recruitment and onboarding, training and development, to our assessments of performance and promotion. Our Code sets out our culture as well as the commitments GSK and our people make so we can deliver on our ambition in the right way. Our people sign up to The Code annually and personally commit ‘I’m in’. + See The Code on gsk.com1 Helping people thrive Making GSK a place where people thrive is core to our Ahead Together ambition. While thriving is different for each individual, there are common themes that matter to everyone. Firstly, a belief in our purpose and a desire to live our culture and contribute to delivering our ambition. Secondly, feeling included and able to be yourself with opportunities to keep growing, with the support, feedback and space needed to succeed. And finally, feeling good, with positive mental, physical, financial and social wellbeing. This means GSK should be a place where people feel welcome and valued, in an environment (including our policies, workplaces and ways of working) that enables and supports them to deliver at their best. Welcoming and developing outstanding people We are committed to developing outstanding people and giving them opportunities to grow. We expect all our people to have an agreed development plan, regardless of grade or role, based on a conversation to understand what space and support they need to succeed. We continue to invest in learning and development initiatives which everyone can access through our Keep Growing Campus, our training and knowledge sharing platform. (1) https://www.gsk.com/en-gb/company/governance/compliance/#the-code 14 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Our culture and people continued Maintaining momentum on diversity, equity and inclusion We are continuing our focus on building a more diverse organisation and an equitable and inclusive culture so that everyone feels welcome, valued and included. By taking steps to ensure equal opportunity and non-discrimination, we are delivering on our ambition to make our leadership and teams more diverse and inclusive. We support development for all with numerous offerings for our employees, including an award-winning leadership development programme, Accelerating Difference. Also, all our people complete a mandatory DEI module as part of our annual training, this year focused on how to create an inclusive workplace so all our people can thrive. For more details on our DEI aspirations, see the Responsible Business section on page 52. Health, wellbeing and volunteering Our health and wellbeing benefits support people through different life stages and are fair and inclusive. These include: a global minimum standard of 18 weeks’ parental leave for primary and secondary carers for all forms of family, a global minimum standard for care of a family member for end of life or serious health emergencies, insured benefits to include same-sex partners wherever possible, and mental health training – available to everyone. We have also enhanced our financial wellbeing support for employees by introducing the ‘nudge’ financial education platform in over 50 countries, helping people manage their finances and achieve their financial goals. In 2023 we reignited volunteering across the company, focused on our ambition and charitable investment themes (Health for people, Health for the planet, Innovators for the future). All employees can volunteer for one or two days each year by taking part in team-based hands-on ‘Together Days’ or through skills-based volunteering. A smaller number of people can volunteer up to four days each year for selected skills-based volunteering projects. Performance with Choice Performance with Choice, our approach to hybrid working for those in office-based roles (about a quarter of our people), allows the right balance of on-site and remote working. We are clear in our expectations that people take accountability to spend enough time together in person, while maintaining flexibility, to help us continue to build our sense of community and connectedness, enable development and achieve our Ahead Together ambitions. Data from our annual employee survey shows broad support for our approach and expectations. Recognising and rewarding our people Sharing our success and recognising and rewarding our people equitably, not just on the progress we have made but how we have made it, continues to be an important part of our culture. In addition to our bonus scheme that rewards performance across the company, each year we award 10% of our people with extra ‘Ahead Together’ awards for delivering exceptional performance in line with being accountable for their impact, ambitious for patients and doing the right thing. And we identify 5% of people as having missed performance for those not delivering on their objectives or living the culture. How our people experience GSK To ensure we continue to listen to our people, we regularly measure their experience of GSK as a place to work. This includes an annual survey for all employees featuring questions on engagement, confidence, inclusivity, our culture focus areas and trust priorities. We are proud that our engagement levels remained high at 81% in 2023. We also continue to see high scores with positive upward trends in confidence in delivery of our strategy and our culture focus areas – ambitious for patients, accountability for impact and doing the right thing – as well as measures of inclusion. In 2023 we expanded analysis of the survey to understand differences in employee experience across diverse characteristics. We continue to make good progress in creating a culture and workplace where people feel a sense of belonging and can thrive. To measure the effectiveness of our global managers, their teams provide feedback through an annual One80 survey and managers receive anonymised aggregate feedback. In 2023, 78% of our managers were rated as highly effective by their teams. 15 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development We combine the science of the immune system with technology and outstanding talent to find new ways to prevent and treat the most challenging diseases, better and faster. 16 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development Highlights 71 vaccines and medicines in the pipeline 18 4 in phase III/registration major approvals – Arexvy, the world’s first RSV vaccine for older adults, approved in the US, EU and Japan – Apretude, long-acting preventative treatment for HIV, approved as the first and only HIV prevention option in Europe – Ojjaara/Omjjara approved in the US, EU and UK as the first and only treatment for both newly diagnosed and previously treated myelofibrosis patients with anaemia – Jemperli approved in the US, EU and UK as the only frontline immuno-oncology treatment, in combination with chemotherapy, for patients with dMMR/MSI-H primary advanced or recurrent endometrial cancer – Shingrix vaccine for shingles approved for people at risk over 18 in Japan and positive data from first efficacy trial in adults aged 50 and over in China – Positive phase III data for our MenABCWY vaccine candidate, supporting filing in 2024 – US FDA Fast-Track designation for gonorrhoea vaccine candidate – Targeted business development including acquisition of Bellus Health and Aiolos Bio1 (respiratory), licence agreements with Janssen (infectious diseases) and Hansoh Pharma (oncology) Our R&D approach Our R&D purpose is to unite science, technology and talent to get ahead of disease. This is how we discover and develop the vaccines and medicines that will transform people’s lives. In 2023, our R&D expenditure was £6.2 billion, up 13% AER and 14% CER on 2022, driven by investment across the portfolio. We’ve also strengthened our pipeline and technology capabilities through business development, seeking out new, differentiated opportunities in diseases with high patient need. We now have 19 vaccines and 52 medicines in development, many with the potential to be first-in-class or best-in-class. In a revolutionary era of science and technology, we’re making the most of rapid advances to drive the discovery and development of vaccines and medicines. Across our pipeline, we consider not just how we can prevent disease in the first place, but also intervene and treat earlier to change its course, preventing or slowing progression of an illness and limiting longer-term complications. Focusing on execution, technology and culture Our priorities in R&D are: – execution, to accelerate our pipeline, including with business development, to deliver innovative vaccines and medicines, see page 18 – technology, to deliver more innovation, better and faster, using new platform and data technologies that speed discovery and development and improve the chance of success, see page 27 – culture, to create an agile, innovative environment that’s ambitious for patients and attracts the best people, scientists and partners, see page 29. For more on why and how prevention underpins our purpose to get ahead of disease, see page 13 (1) Closed in early 2024. 17 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Execution Pipeline acceleration and business development for transformational vaccines and medicines. Our broad portfolio and pipeline, based on the science of the immune system and the use of new platform and data technologies, continues to strengthen, with key milestones across our core therapeutic areas in 2023. This positive momentum, together with further business development, underpins our confidence in delivering our upgraded growth outlooks for the medium and long term. Across all phases, our pipeline now has 71 vaccines and medicines. More than 70% modulate the immune system and a similar proportion are based on genetic evidence. In 2023, we began eight phase I programmes, moved 14 assets into phase II and three into phase III. Since 2016 our development cycle times have shortened by 20%, or 3.7 years, with a median of 9.6 years, compared to the industry's 11.4 years. We’re investing heavily in our late-stage pipeline to drive growth in line with our therapeutic area strategies. We rigorously evaluate our early-stage portfolio to back the right programmes to maximise our impact on health and unlock pipeline value. Reflecting our progress in 2023, we are now planning for at least 12 major product launches from 2025. Infectious diseases Infectious diseases affect everyone, everywhere, putting a major strain on societies and healthcare systems. Our combined expertise in vaccines and medicines means we can focus on both prevention and treatment of infectious diseases, resulting in significant public health benefits, reduced deaths and increased productivity. Two thirds of the vaccines and medicines in our pipeline address infectious diseases (including HIV), and we’re a world leader in this area. – Infectious diseases are responsible for an estimated one in six deaths globally. – Around one billion people are infected every year by viruses like RSV, influenza virus and SARS-CoV-2 and many need hospital treatment. – Millions more struggle with bacterial and fungal infections or live with chronic viral conditions like hepatitis B (hep B) and HIV. – Vaccine-preventable diseases impose significant medical and economic costs related to treatment and to cover resulting productivity losses. (1) Closed in early 2024. In 2023, we reinforced our status as a world leader in infectious diseases. We gained approvals in the US, EU and Japan for our world-first respiratory syncytial virus (RSV) vaccine for older adults, Arexvy, and in Japan for our shingles vaccine, Shingrix, for people at risk over 18. In HIV, we’re reshaping treatment and prevention by delivering long-acting regimens, such as Apretude, approved in Europe for HIV prevention in 2023. In oncology, we’re optimising our portfolio, focusing on blood and women's cancers, and breakthroughs in immuno-oncology. In 2023, there were approvals for Ojjaara, the first treatment specifically indicated for myelofibrosis patients with anaemia and Jemperli, our frontline treatment for endometrial cancer. We also had positive phase III results for Blenrep, our treatment for multiple myeloma. Business development is a critical contributor to growth, creating extra value for patients, partners and shareholders. Major deals include our acquisition of Bellus Health and Aiolos Bio1 and new collaborations including with Janssen and Hansoh Pharma which we believe will bolster our existing strengths across our therapeutic areas. We focus on four therapeutic areas: – infectious diseases, see below – HIV, see page 22 – respiratory/immunology, see page 23 – oncology, see page 25. For over 70 years, we’ve pioneered novel research methods and technologies to help protect people against infectious diseases including: chronic infections (hepatitis B, HIV, shingles), seasonal infections (RSV, influenza), common childhood diseases (measles), rare but devastating conditions (meningitis) and a range of bacterial infections made more challenging by antimicrobial resistance (AMR); as well as diseases which predominantly affect lower- income countries (malaria, TB, rotavirus). Of the more than 2.5 billion people we reach this decade, a significant majority will be through our infectious disease portfolio, which is the broadest in the industry. In 2023, key highlights have included approvals for Arexvy, our world-first RSV vaccine for adults aged 60 and above, and positive phase III data for our pentavalent meningitis vaccine candidate. 18 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Tackling RSV with the world's first Arexvy vaccine – Around 470,000 older people each year face hospital in immunity that can make protecting older people from infectious diseases challenging. stays because of RSV. – People with underlying conditions like chronic obstructive pulmonary disease (COPD), asthma, diabetes and heart disease are at increased risk of the severe outcomes of RSV, such as pneumonia. – Around 14,000 people a year die from RSV in the US, and in the EU the figure is closer to 20,000. In 2023, Arexvy was approved in the US, EU, Japan and several other countries for the prevention of lower respiratory tract disease caused by RSV in adults aged 60 and older. This followed positive phase III data published in the New England Journal of Medicine which showed exceptional efficacy in older people, including those with certain underlying medical conditions, and against severe RSV. In 2023, we reported data from season two of our ongoing phase III trial showing vaccine efficacy over two complete RSV seasons. The clinical development programme will continue to evaluate longer-term follow-up and the optimal timing for potential revaccination. In the US, following approval by the US Food and Drug Administration (FDA), the US Centers for Disease Control and Prevention’s Advisory Committee on Immunisation Practices recommended that adults 60 years of age and older may receive a single dose of the vaccine using shared clinical decision-making. Arexvy is now available across the US, Canada and multiple European countries. Regulatory reviews in other countries are ongoing, with approvals and launches expected throughout 2024 and beyond. In 2023, we also reported positive preliminary data from a clinical trial in people aged 50 to 59 at increased risk of RSV showing non-inferior immune responses compared to adults aged 60 and older. Based on these data, in February 2024, the US FDA accepted a regulatory application under Priority Review to extend the vaccine's indication for adults aged 50-59 at increased risk. Regulatory submissions for adults aged 50-59 were also accepted by the European Medicines Agency and the Japanese Ministry of Health, Labour and Welfare. In 2024, we expect to generate further data in people aged 18 and older at increased risk of RSV, as well as from trials exploring co-administration with other adult vaccines including for shingles and pneumococcal disease. Expanding the use of our shingles vaccine – One in three people develop shingles in their lifetime, sometimes with serious consequences like long-term nerve pain and loss of vision. Shingrix, our vaccine to protect people from shingles, has launched in 40 countries for people over 50 and for people over 18 at increased risk of shingles. Shingrix was specifically designed to combine one of our adjuvants with an antigen selected to enhance a protective immune response, based on our understanding of the virus that causes shingles. This formulation helps overcome the natural age-related decline In 2023, Shingrix was approved in Japan for the prevention of shingles in people over 18 at increased risk, for instance due to immune suppression or immune deficiency. The vaccine has been approved in Japan for people aged 50 and older since 2018. The latest approval followed six clinical trials with people aged 18 or older at increased risk of shingles, including those who had undergone stem cell transplants or kidney transplants, or who had blood cancer, solid tumours or HIV. A regulatory application for this patient group was also accepted for review by the China National Medical Products Administration in February 2024. In 2023, we reported data from the first-ever efficacy trial of Shingrix in China, which demonstrated 100% vaccine efficacy. These results come from the phase IV trial (ZOSTER-076), which evaluated the efficacy and safety of the vaccine in preventing shingles in adults aged 50 and older. Progressing towards a 5-in-1 meningitis vaccine – Around 1.2 million people contract invasive meningococcal disease (IMD) each year, and one in six people diagnosed with it will die. – At least one in five IMD survivors will have long-term disabilities including brain damage, deafness and nervous system problems. Our meningitis ACWY vaccine Menveo and meningitis B vaccine Bexsero together protect against most forms of IMD. Our first-generation 5-in-1 vaccine candidate combines these vaccines, aiming to protect against the serotypes that cause most disease globally in a single vaccine. In 2023, we presented preliminary phase III data to the European Society for Paediatric Infectious Diseases showing the vaccine candidate performed statistically as well as Bexsero and Menveo in people aged 10 to 25. It’s currently the only investigational 5-in-1 vaccine with data to show immunological effectiveness against 110 diverse meningitis B invasive strains in a trial. Multivalent vaccines of this kind have the potential to support the WHO's strategy to eradicate meningitis by 2030. We also have a second generation 5-in-1 vaccine in phase II development, which aims to improve protection against B strains in broader age groups. Trials for our investigational medicine for chronic hepatitis B (CHB) – Around 300 million people are living with CHB. – Only about 10% of these people have a diagnosis, 5% receive treatment and almost a million die each year. – Currently, patients take nucleoside/nucleotide analogues (NA), often for life, because they suppress the virus but rarely clear it. For 35 years, we’ve been a leader in hepatitis B vaccination. Bepirovirsen, our triple-action antisense oligonucleotide, has the potential to be the cornerstone of functional cure for patients with CHB. It could eliminate the need for continued therapy, ultimately reducing the long-term risk of developing liver complications. 19 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Hope against hepatitis B 'I didn’t know anything about hepatitis B until after my husband and I adopted our daughter, Maren, when she was just a few months old,' said Maureen, a hepatitis B caregiver and advocate. 'My heart broke as I watched my baby cry while receiving the injections and endure the resulting side effects. There is no doubt that chronic hepatitis B can be scary – and the stigma makes it more so, but it doesn’t have to be a lifelong burden – there is reason for hope. I’m energised by ongoing research into new treatment options that could alleviate the burden of frequent and often invasive treatments for the management of chronic hepatitis B. There are people, including scientists at GSK, who are working towards finding a functional cure.' Bepirovirsen is the only single agent in phase III development that has shown a clinically meaningful functional cure response for patients with CHB receiving NA therapy, as demonstrated in the B-Clear and B-Sure clinical trials. As well as developing bepirovirsen in our phase III trials for patients receiving NAs, we are also exploring potential sequential therapy options with the aim of helping more patients achieve functional cure. In October 2023 we announced an exclusive licence agreement for a phase II small interfering RNA-based therapeutic, originally developed by Arrowhead Pharmaceuticals. This provides a further opportunity to develop a potential novel sequential regimen to benefit a broader group of patients and potentially drive higher functional cure rates. Other infectious diseases Pneumococcal disease – Pneumococcal disease is the name for any illness caused by the Streptococcus pneumoniae bacterium, which is a leading cause of acute bacterial diseases and an important area of growing antimicrobial resistance. – Multiple licensed pneumococcal vaccines are available, however the burden of pneumococcal disease remains significant. – In the US alone, it is estimated that pneumococcal pneumonia causes 150,000 hospitalisations every year. – The WHO estimates that about one million children die of pneumococcal disease every year. Our novel 24-valent vaccine candidate (currently in phase II development) and 30 plus-valent pneumococcal vaccine candidate (currently in pre-clinical development), added to our pipeline through our 2022 acquisition of Affinivax, both incorporate innovative MAPS platform technology. Maureen and Maren MAPS potentially enables higher antibody responses against more disease-causing serotypes for broader and stronger protection (see page 27). We continue to examine potential acceleration options in the 24- and 30-plus valent programmes for infants and adults. Herpes simplex virus – Genital herpes is a chronic sexually transmitted infection caused by herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2) viruses. – Worldwide, an estimated 683 million people aged 15 to 49 are living with HSV-2 or genital HSV-1 infection. – Many patients suffer frequent outbreaks along with psychological morbidity, stigma and a threefold increase in the risk of acquiring HIV. GSK 3943104 is our candidate against HSV that contains HSV antigens complemented with an adjuvant, designed to stimulate immune responses in people already infected with HSV. Following the successful completion of a phase I first- time-in-humans study, a phase II first-time-in-patients proof of concept trial started in late 2023 and is assessing two formulations in adults with a history of genital herpes outbreaks. If successful, we hope that this could help better control symptomatic outbreaks and viral shedding while mitigating the associated emotional burden and improving quality of life for people living with genital herpes. Influenza – Influenza remains one of the world’s greatest public health challenges. – Every year, there are an estimated one billion cases around the world, many resulting in severe illness and death. 20 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Our adjuvanted pandemic influenza vaccine has been extensively studied and consists of egg-based antigen and pandemic adjuvant AS03. We have agreements with the US, Canada, Europe and the WHO to provide at least 200 million doses of pandemic influenza vaccine in the event of a global health emergency. Egg-based influenza vaccines are the backbone of worldwide efforts to limit the impact of seasonal influenza. Different platforms and technologies will continue to be needed in the future and we’re committed to playing our part in meeting an important patient need. We’re exploring opportunities to develop mRNA-based influenza vaccines through our collaboration with CureVac. Building on positive phase I results for modified monovalent mRNA vaccine candidates that target COVID-19 and monovalent flu, we’re developing a next-generation multivalent mRNA flu vaccine to protect against multiple influenza virus strains. Phase I/II trials are underway. COVID-19 Now that the acute phase of the COVID-19 pandemic is over, our focus is on next-generation platforms and combination vaccines that have the potential to protect against multiple seasonal respiratory viruses. In 2023, our COVID-19 mRNA development programme with CureVac progressed to a phase II clinical trial and we recently reported positive interim data for both the monovalent and bivalent vaccine candidates. Human papillomavirus Human papillomavirus (HPV) is a common sexually transmitted infection affecting around 14 million people a year in the US alone. It often has no symptoms but can cause genital warts and several types of cancer. HPV is associated with nearly all (99%) cases of cervical cancer, which is the fourth most common cancer among women globally and causes an estimated 342,000 deaths each year. HPV also accounts for about 5% of all cancers worldwide, including 90% of anal cancers and 70% of oropharyngeal cancers. We’re working with Innovax on a next-generation adjuvanted vaccine to protect against more types of HPV. Antibiotics and antimicrobial resistance Antimicrobial resistance (AMR) is one of the world’s top 10 health threats. It’s estimated that, without action, AMR, including antifungal resistance, could contribute to 10 million deaths per year by 2050 and cause an economic loss of £100 trillion. Across our medicines and vaccines pipeline, we have more than 30 projects relevant to AMR, 12 of them targeting pathogens deemed ‘critical’ or ‘urgent’ by the WHO. Moving towards a potential treatment for uncomplicated urinary tract infections and urogenital gonorrhoea – Over half of women are affected by uncomplicated urinary tract infections (uUTI) in their lifetime, with over a quarter suffering recurring disease. – Despite concern over rising resistance to existing treatments, there’s been no new class of antibiotics in uUTI for over two decades. Our investigational antibiotic gepotidacin is a novel mechanism triazaacenaphthylene antibiotic for uUTI and gonorrhoea, discovered and developed by us, and part-funded by our partnership with the US Biomedical Advanced Research and Development Authority (BARDA). In 2023, positive phase III data showed it has the potential to be the first in a new class of oral antibiotics for uUTI in over 20 years. In the EAGLE-2 and EAGLE-3 phase III trials, which were stopped early for efficacy in November 2022 following a planned interim analysis, gepotidacin performed as well as nitrofurantoin, an existing first-line treatment for uUTI. In the EAGLE-3 trial, gepotidacin demonstrated statistically significant superiority over nitrofurantoin. Treating complicated urinary tract infections with tebipenem Through our partnership with Spero Therapeutics, Inc., we have an exclusive licence agreement for tebipenem HBr, a late-stage oral carbapenem antibiotic with the potential to treat complicated urinary tract infections (cUTIs). In December 2023, the first patient was dosed in PIVOT-PO, our pivotal phase III trial for tebipenem. If approved, tebipenem HBr will address an unmet medical need for a novel oral antibiotic as an alternative to intravenous hospital therapy for drug-resistant cUTIs. Vulvovaginal candidiasis In 2023, we also signed an exclusive licence agreement with Scynexis to develop and further commercialise Brexafemme, a US FDA-approved first-in-class antifungal treatment for vulvovaginal candidiasis (VVC) and for reducing the incidence of recurrent VVC. Brexafemme complements gepotidacin and tebipenem, and reinforces our commitment to developing new antibiotic and antifungal treatments in areas of high unmet medical need. Fast-tracking our gonorrhoea vaccine – Gonorrhoea is the second-most prevalent bacterial sexually transmitted infection worldwide, with an estimated 82 million new cases each year. – AMR to gonorrhoea has increased over the past 80 years, rendering many classes of antibiotics to treat the disease ineffective and making a vaccine even more important to the global effort to tackle AMR. Our investigational Neisseria gonorrhoeae (NgG) vaccine, based on our generalised modules for membrane antigens (GMMA) technology, aims to protect people aged 16 and older. Currently in an ongoing phase I/II efficacy trial, NgG received a Fast-Track designation from the US FDA in 2023, accelerating its path to FDA submission. . 21 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued HIV For decades, we’ve transformed the lives of people living with HIV by making breakthroughs in treatment and prevention. Our work to develop long-acting injectable medicines means that many only need therapy a few times a year, instead of once a day. – The WHO estimates there were approximately 1.3 million new HIV infections globally in 2022, with the burden greatest in sub-Saharan Africa. – In the US, about two-thirds of people living with HIV are virally suppressed and there were more than 36,000 new diagnoses in 2021. – There remains a pressing need for new approaches to treatment and prevention. We work on HIV through ViiV Healthcare, which we majority own, with Pfizer and Shionogi as shareholders. ViiV Healthcare is the only company that is 100% focused on the treatment and prevention of HIV. Our goal is to leave no person living with HIV behind. We’ve focused research on transforming the experience of people living with HIV through novel treatment options that allow them to take fewer drugs or take them much less often. We’ve also developed a long-acting regimen that can prevent HIV. The 40-year fight against HIV The official start of the AIDS epidemic is considered to be June 1981, when the Morbidity and Mortality Weekly Report noticed that a rare pneumonia was being seen in previously healthy men who have sex with men. It would be several years before HIV was identified as the underlying cause. Marty St Clair and other scientists at Burroughs Wellcome – a predecessor company to GSK – urgently began a search for a potential new medicine to treat HIV and AIDS. The group went on to develop Zidovudine, the first medicine, which was approved in the US in 1987. Nearly 40 years on, Marty continues to work to treat and prevent HIV transmission in her role as clinical director for ViiV Healthcare. She is optimistic about the outlook for innovation in HIV. 'We’ve pretty much given people their lives back,' said Marty. 'It’s a hopeful time.' Transforming patients’ lives with long-acting regimens Cabenuva (cabotegravir; rilpivirine) is the world’s first and only complete long-acting injectable regimen to treat HIV. It means some patients have treatment only six times a year instead of taking medicine orally every day. Our SOLAR study data, announced in 2023, showed Cabenuva is as effective as daily Biktarvy tablets for treating HIV. The 12- month findings also showed that nine out of ten participants switching from Biktarvy to Cabenuva preferred the long- acting regimen. Apretude (long-acting cabotegravir), launched in 2022, is the world’s first and only long-acting injectable pre-exposure prophylaxis (PrEP) to reduce the risk of sexually transmitted HIV. Two large phase III studies demonstrated that Apretude was superior to daily oral PrEP (TDF/FTC) in men and women. And, in the open label phase, when given the choice, the majority of study participants chose Apretude over oral TDF/FTC. The European Commission authorised Apretude in 2023 in injectable and tablet form. This followed a positive opinion from the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP). Apretude is also approved in Australia and South Africa, among many others. Looking to the future of long-acting treatment and prevention Through a new formulation (reformulated CAB), we’re now focused on progressing to injectable doses every four months, doubling today’s interval for cabotegravir for treatment and PrEP, which would halve visits to the clinic to three times a year. ViiV Positive Action outreach 22 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued We aim to make this a reality for prevention by 2026, with a registrational study starting in 2024. For treatment, we aim to deliver by 2027, by evaluating possible combinations of reformulated CAB with rilpivirine or our broadly neutralising antibody, N6LS. In 2023, we completed a study that combined N6LS with Halozyme’s recombinant hyaluronidase (PH20) technology, which allows delivery of a larger volume of drug through subcutaneous dosing. This showed it’s possible to deliver a single subcutaneous dose that’s well-tolerated and can last up to four months. Beyond this, six-monthly doses are our goal by the end of the decade by partnering our new integrase inhibitors, VH184 or VH310, with new-mechanism-of-action agents such as capsid inhibitors. Respiratory/immunology We’ve been leaders in delivering medicines that help manage asthma and COPD for over 50 years. Our research looks to harness the science of the immune system to develop medicines that reduce signs and symptoms of disease, address treatment resistance and slow the progression of immune-mediated conditions. These include lupus, severe asthma with an eosinophilic phenotype and other inflammatory diseases. We help millions of people with respiratory and immune conditions worldwide with our current portfolio. Advancing the science and treatment of IL-5 mediated diseases For more than 25 years we have been leaders in researching the roles that eosinophils (a type of white blood cell) and interleukin-5 (IL-5) play in health and disease. – Eosinophil-driven diseases are associated with heightened levels of eosinophils. When eosinophils infiltrate certain tissues, they can cause inflammation and organ damage which, over time, can affect patients’ day- to-day life. – IL-5 is the major cytokine responsible for the proliferation, activation and survival of eosinophils, making it a proven treatment target for patients with higher levels of eosinophils. – IL-5 mediated conditions encompass a range of diseases for which there have been few, if any, effective treatments. These include respiratory conditions like severe asthma with an eosinophilic phenotype, COPD and chronic rhinosinusitis with nasal polyps (CRSwNP), and rarer conditions like eosinophilic granulomatosis with polyangiitis (EGPA) or hypereosinophilic syndrome (HES). Our research aims to redefine treatment goals across these conditions, going beyond optimal management of daily symptoms, to modify the course of disease. This could slow or halt disease progression, reduce the risk of organ damage and even mean some people could achieve clinical remission. Moving towards self-injected long-acting treatment Our other main aim is to develop the world’s first long- acting treatment that people living with HIV can inject themselves. This will allow individuals to dose at home and reduce the number of clinic visits. We are targeting dosing every two to three months, with efficacy and tolerability similar to Cabenuva. In short, our goal is to develop new agents for HIV treatment and prevention that reduce the burden of treatment and allow people to have improved quality of life. Nucala is a first-in-class anti-IL5-biologic (monoclonal antibody) that targets and directly inhibits IL-5. It is the only treatment in the US and Europe with indications in four IL-5 mediated diseases: severe asthma with an eosinophilic phenotype, CRSwNP, EGPA and HES. In 2023, the Japanese Ministry of Labour, Health and Welfare accepted for review a supplementary new drug application for Nucala to treat CRSwNP in adults. This submission is based on data from the pivotal phase III MERIT trial studying the safety and efficacy of Nucala in people with CRSwNP. In January 2024, the China National Medical Products Administration approved Nucala as an add-on maintenance treatment for severe asthma with an eosinophilic phenotype. Nucala is the first targeted IL-5 treatment in China for adult and adolescent patients with the condition. Depemokimab is our novel monoclonal antibody developed for its affinity for IL-5 and long-acting inhibition of the IL-5 pathological process, which includes suppression of eosinophil activity. It is the first potential ultra-long-acting anti-IL-5 biologic that treats a range of IL-5 mediated diseases. Our phase III programme continues to make progress across diseases including severe asthma, CRSwNP, HES and EGPA. Currently, approved IL-5 inhibitors are dosed every four or eight weeks, while depemokimab is designed to be administered every six months, addressing the challenges commonly associated with more frequent dosing including adherence anxiety and emotional burden. Reaching a broader range of asthma patients In early 2024, we acquired Aiolos Bio, Inc. The acquisition adds AIO-001, a phase II-ready, long-acting antibody that targets the clinically validated TSLP pathway to our respiratory pipeline. This could redefine the standard of care for asthma patients with dosing every six months. AIO-001 has the potential to expand our reach to a broader portion of asthma patients, including the 40% of severe asthma patients with low T2 inflammation where treatment options are still needed. In addition to the treatment of adult patients with asthma, AIO-001 also has the potential for 23 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued additional indications including chronic rhinosinusitis with nasal polyps. Progress towards a treatment for refractory chronic cough with camlipixant – Approximately 28 million people suffer from chronic cough, with about 10 million worldwide suffering from refractory chronic cough (RCC) for over a year. – RCC is a cough that persists for more than eight weeks and doesn’t respond to treatment for an underlying condition or is otherwise unexplained. – For decades there have been no effective treatments for RCC, with patients often suffering from depression, urinary incontinence, rib fractures and loss of sleep. In 2023, we acquired Bellus Health, which included camlipixant, a potential best-in-disease and highly selective oral P2X3 antagonist currently in phase III development as a first-line treatment for adults with RCC. Current clinical data show that by selectively inhibiting P2X3 receptors, camlipixant may reduce cough frequency for patients suffering from RCC with a relatively low incidence of dysgeusia. This is the taste disturbance associated with other medicines that broadly target the P2X2/3 receptor. We expect data in 2025 from the phase III CALM development programme, evaluating the efficacy and safety of camlipixant. Treating systemic sclerosis with Benlysta We continue to work to realise the full potential of Benlysta, our anti-B Lymphocyte stimulator (BLyS) monoclonal antibody, so that people affected by a range of immune- mediated conditions beyond lupus and lupus nephritis (LN) can benefit from its targeted mode of action, and reassuring safety profile. Systemic sclerosis (SSc) is a rare autoimmune disease that causes atypical growth of connective tissues and can affect the musculoskeletal system, heart, lungs, kidneys, skin and other organs. Interstitial lung disease (ILD), marked by inflammation and scar tissue build-up in the lungs, affects as many as half of people living with SSc. Current treatment options are limited. In 2023, the US FDA granted Orphan Drug Designation (ODD) to Benlysta as a potential treatment for SSc. The ODD is a special status granted to support development and evaluation of potential medicines to treat, diagnose or prevent rare diseases or disorders affecting fewer than 200,000 people in the US. We began a phase II/III trial for SSc-associated ILD in 2023. We will be exploring other potential studies in a wider range of potential indications in 2024. Benlysta remains the first and only approved biologic for both systemic lupus erythematosus (SLE) and LN in more than 50 years. Its robust efficacy and long-term safety have been recognised in updated recommendations from the European Alliance of Associations for Rheumatology (EULAR) for the management of SLE and LN, endorsing earlier use in the treatment pathway. We plan a phase IV study in early 2024 to further inform the proactive management of lupus to prevent organ damage. Benlysta has been approved for use in over 75 countries to treat adults with SLE. This has been extended to include children aged five and older with SLE in the US, Japan, the EEA countries, the UK and over 15 other countries. Benlysta is currently approved to treat adults with LN in the US, all EEA countries, the UK and over 15 further countries. In the US, this indication includes children aged five and older with LN, and reviews for this continue in other countries. Remission could be possible for severe asthma Shelby Gorman, a GSK employee, knows all too well the negative impact of severe asthma on a child’s life. ‘The doctor said to us – when was the last time you had a day when you felt good all day?’, Shelby says. ‘My daughter could not remember one day when she felt well ever, in her life.’ After many years of frequently being hospitalised due to exacerbations, Shelby’s daughter, Joelle, received a more accurate diagnosis and started on an appropriate targeted treatment. For the first time she was able to live her life without respiratory infections and no daily antihistamines. With our expertise in respiratory disease and deep understanding of the immune system, our scientists along with other global specialists are developing solutions to help some people with severe asthma achieve clinical remission. Shelby and Joelle 24 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Oncology Cancer, one of the world’s major causes of death, is a field where patients’ needs are still widely unmet and treatment options remain limited. We have an emerging portfolio in oncology that is focused on seeking solutions for blood and women's cancers, and making transformative break- throughs in immuno-oncology. Ojjaara (momelotinib), Blenrep (belantamab mafodotin), Jemperli (dostarlimab) and Zejula (niraparib) are the strong foundation of our work in blood and women's cancers. Our goal is to realise the full potential of our existing medicines, as well as expand our portfolio in areas of high unmet need. In 2023, we received approval in the US for Ojjaara our treatment for myelofibrosis. Omjjaara was then approved in the EU and UK in January 2024. We also received approval in the US, EU and UK for our immuno-oncology therapy Jemperli plus chemotherapy as a first-line treatment for endometrial cancer patients with a certain biomarker. We continue to evaluate dostarlimab in studies that further reinforce our ambition for it to become the backbone of our ongoing immuno-oncology research and development programme. Blood cancers Ojjaara: helping myelofibrosis patients with anaemia – Myelofibrosis (MF) is a rare blood cancer affecting around 25,000 people in the US. – Nearly all MF patients will eventually develop anaemia, requiring regular blood transfusions and leading over 30% to stop treatment with established therapies. – In addition to anaemia, patients can experience debilitating symptoms like night sweats, fatigue and bone pain, as well as an enlarged spleen (splenomegaly), bringing pain and inflammation and frequent infection risk. Ojjaara, taken orally once a day, is the only medicine specifically indicated for newly diagnosed and previously treated MF patients with anaemia. It treats anaemia, along with the constitutional symptoms and enlarged spleen that accompany the disease. This means it potentially offers a new standard of care for patients, as established treatments can further exacerbate anaemia. In September 2023, the FDA granted broad, line-agnostic approval for Ojjaara for the treatment of primary or secondary MF in adults with anaemia, regardless of previous MF therapy. This was followed by a positive CHMP opinion in November 2023 and approval by the European Commission, as well as MHRA approval, in January 2024. We’ve also submitted a new drug application in Japan. Blenrep: our treatment for multiple myeloma – Multiple myeloma is the third most common blood cancer globally and is generally considered treatable but not curable. – Approximately 176,000 new cases of multiple myeloma are diagnosed globally each year. – Research into new therapies is needed, as multiple myeloma commonly becomes refractory to available treatments. Blenrep is our antibody-drug conjugate treatment for relapsed/refractory multiple myeloma. Our DREAMM (Driving Excellence in Approaches to Multiple Myeloma) clinical development programme continues to evaluate the potential of Blenrep to address unmet need in early lines of treatment and in combination with novel therapies and standard of care treatments. In November 2023, we announced positive phase III results from the DREAMM-7 trial, showing potential for Blenrep combination therapy to benefit patients in earlier treatment lines. Interim analysis of DREAMM-7 showed that patients receiving Blenrep in combination with bortezomib and dexamethasone (BorDex) lived longer without their disease progressing than those receiving daratumumab plus BorDex, an existing standard of care combination therapy. We are sharing this data with health authorities and the scientific community as we await the results from DREAMM-8, another phase III combination trial exploring Blenrep’s potential in earlier therapy lines. Also during 2023, health authorities continued to review existing monotherapy indications for Blenrep in later therapy lines based on the results of previous studies. This included in December 2023, the EMA recommending against renewal of the conditional marketing authorisation for its existing fourth line and later monotherapy indication. Women's cancers Jemperli: a backbone immuno-oncology therapy – Endometrial, or uterine, cancer is the sixth most common cancer in women worldwide, with an estimated 417,000 new cases and 97,370 deaths in 2020. – About 30% of endometrial cancer cases have a biomarker known as dMMR/MSI-H. – Patients with this type of endometrial cancer have faced significant unmet need and typically experience poor long-term outcomes with standard of care chemotherapy. In 2023, Jemperli became the only immuno-oncology treatment approved in the US, EU and UK in the frontline setting in combination with chemotherapy for patients with mismatch repair deficient or microsatellite instability-high (dMMR/MSI-H) primary advanced or recurrent endometrial cancer. In the RUBY trial supporting these approvals, Jemperli plus chemotherapy showed a 71% reduction in the risk of disease progression or death compared to chemotherapy alone. 25 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued In 2023 we announced two additional positive data readouts for the RUBY phase III trial. In part 1 of the trial, Jemperli plus chemotherapy showed statistically significant and clinically meaningful overall survival benefit compared to chemotherapy in the overall population of patients with primary advanced or recurrent endometrial cancer. Jemperli is the only immuno-oncology combination regimen to achieve this. Part 2 of the RUBY trial, which evaluated Jemperli plus chemotherapy followed by Jemperli plus Zejula for the treatment of primary advanced or recurrent endometrial cancer, demonstrated significantly improved progression-free survival compared to chemotherapy alone in both the overall and mismatch repair proficient/ microsatellite stable (MMRp/MSS) patient populations. Jemperli is also approved as a stand-alone treatment for certain types of endometrial cancer. Earlier in 2023, the FDA converted the accelerated approval for Jemperli as a second-line treatment into a full approval as a monotherapy for adult patients with dMMR recurrent or advanced endometrial cancer, as determined by an FDA-approved test, that has progressed on, or following, a prior platinum-containing regimen in any setting, and who aren’t candidates for surgery or radiation. The European Commission's conditional approval for Jemperli as a monotherapy for adult patients in the same patient population was also converted to full approval. Zejula: our PARP inhibitor for ovarian cancer and beyond We continue to develop Zejula in multiple pivotal trials, assessing activity in gynaecologic cancers and other solid tumours and evaluating several potential combinations of Zejula with other therapeutics. Aiming to address the unmet medical needs of patients, the ongoing development programme includes the FIRST phase III trial assessing the potential for niraparib in combination with dostarlimab in first-line ovarian cancer maintenance and the ZEAL phase III trial evaluating niraparib in combination with standard of care for the maintenance treatment of first-line advanced non-small cell lung cancer. In addition, based on promising early clinical data for niraparib in glioblastoma in November 2023, we are exploring next steps for its clinical development in this type of cancer. Other cancers Colorectal cancer – Cancers that start in the colon or in the rectum, both of which are distinct sections of the large intestine, are classified as colorectal cancers. – Colorectal cancer is the second leading cause of cancer- related death and the third most common cancer worldwide, accounting for approximately 10% of all cancer cases. – In 2020, it was estimated that worldwide, there were more than 1.9 million new cases of colorectal cancer and more than 930,000 deaths. In January 2023, the US FDA granted dostarlimab Fast- Track designation for the treatment of dMMR/MSI-H locally advanced rectal cancer. We also started our AZUR clinical trial programme studying dostarlimab in certain colorectal cancer indications. AZUR-1 is a global, open-label, phase II clinical trial to investigate the efficacy and safety of dostarlimab as monotherapy – replacing chemotherapy, radiation and/or surgery – for treatment-naïve patients with dMMR/MSI-H locally advanced rectal cancer. If successful, there’s potential to transform the treatment of some patients with locally advanced rectal cancer. The trial aims to confirm results generated in a separate ongoing investigator-initiated trial by researchers at Memorial Sloan Kettering Cancer Center. In 2023, this trial reported that all participants treated with dostarlimab achieved clinical complete responses, enabling them to avoid surgery, chemotherapy and radiotherapy. We also began our AZUR-2 trial, a phase III trial that evaluates the efficacy of perioperative dostarlimab monotherapy compared with standard of care adjuvant chemotherapy in patients with high-risk early stage dMMR/ MSI-H colon cancer. If approved, this could give patients a new chemotherapy-free option that reduces the risk of disease progression through dostarlimab treatment in both neoadjuvant and adjuvant settings. Lung cancer – Lung cancer is the second most common cancer globally and the most common cancer in men. – In 2020, there were more than 2.2 million new cases of lung cancer worldwide. – The majority of lung cancers fall into a category called non-small cell lung cancer (NSCLC). While this form of lung cancer progresses more slowly, 40% of NSCLC cases will have spread beyond the lungs by diagnosis. In 2023, we published data from our phase II PERLA clinical trial showing a favourable numerical trend in overall survival results for dostarlimab plus chemotherapy compared to pembrolizumab plus chemotherapy in first-line metastatic NSCLC. Data from the PERLA trial supports our ambition for dostarlimab to become a backbone immuno-oncology therapy when used alone and in combination with standard of care and future novel cancer therapies, including targets along the CD226 axis. We have access to antibodies targeting all three known CD226 checkpoints – CD96, PVRIG and TIGIT. Our goal of studying these immune checkpoints in combination with dostarlimab is aimed at increasing the proportion of patients who respond to therapy and improving the durability of response. In 2023, our CD226 axis development programme continued with several early-phase trials underway, including GALAXIES Lung-201, our phase II platform study in first-line metastatic NSCLC that combines dostarlimab with belrestotug, our TIGIT antibody partnered with iTeos Therapeutics. GALAXIES Lung-201 will also explore a triplet combination with dostarlimab, belrestotug, and GSK6097608, our CD96 antibody. In addition, our two phase III trials in NSCLC continued in 2023 with readouts expected in 2024: – COSTAR Lung, our phase III, randomised, open-label three-arm trial is comparing investigational compound cobolimab plus dostarlimab plus docetaxel to 26 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued dostarlimab plus docetaxel to docetaxel alone in patients with advanced NSCLC who have progressed on prior anti-PD-L1 therapy and chemotherapy. – ZEAL, our phase III, randomised, double-blind trial is assessing niraparib in combination with standard of care for the maintenance treatment of first-line advanced NSCLC. Pipeline growth through business development In October 2023, we announced an exclusive licence agreement with the Chinese company Hansoh Pharma for HS-20089, its B7-H4-targeted ADC. This supports our work in developing treatments for ovarian and endometrial cancers, as well as solid tumours. The B7-H4 surface antigen is over-expressed in ovarian and endometrial cancers and often associated with poor prognosis. As well as targeting B7-H4, HS-20089 uses clinically validated ADC technologies such as topoisomerase inhibitor payload (TOPOi). This is a validated mechanism of action in approved anti-cancer medicines and a proven standard of care in treating breast and ovarian cancers. In December 2023, we added to our oncology portfolio of clinical-stage ADCs by entering a second exclusive licensing agreement with Hansoh Pharma for HS-20093. HS-20093, a B7-H3 targeted ADC also utilising a clinically validated TOPOi payload, has shown promising initial clinical activity in lung cancer with potential to address unmet medical need in broader solid tumour indications including colorectal cancer. Technology New platform and data technology are fundamentally transforming how we discover and develop vaccines and medicines, speeding up discovery and development and improving the chance of success. Technology makes us more effective at every stage of the discovery and development process, so that we progress vaccines and medicines that are the first or best of their kind. Our early investment in these capabilities is already leading to differentiated, high-impact vaccines and medicines including a new vaccine for RSV, long-acting HIV prevention, and the prospect of a functional cure for chronic hepatitis B. We combine the power of genetic data and genomic insights with the speed and scale of AI to make better predictions and increase the probability of new vaccines and medicines becoming available for patients. Our AI team – one of the largest in the industry – works with our genomics team to improve how we select disease targets, determine the best technology approach, and identify groups of patients where a treatment might work best. We’re not doing this alone. We partner with the world’s best minds across academia and the tech and biotech industries – from large companies to small start-ups. This collaboration leads to new ways of thinking, so that together we can strive for the most innovative solutions for patients. Using platform technologies to discover and develop novel vaccines and medicines One of the major challenges in addressing diseases where no vaccines or medicines currently exist is that they are difficult to treat with small molecules or biologics. We’re overcoming this challenge by investing in both our own innovation and in external collaborations to develop a range of platform technologies. With platform technology, we pair disease targets with the best treatment modalities, addressing diseases once thought to be too difficult to target with drug discovery. These expand our ability to identify novel vaccine and medicine options to prevent or treat these diseases. We are investing in platform technologies including: Multiple antigen presenting system (MAPS), which allows us to develop multivalent vaccines for complex bacterial infections by introducing T-cell mediated, disease-specific anti-protein immunity. This potentially enables broader coverage against certain disease types and higher immunogenicity than current vaccines, as well as higher antibody responses. We are developing MAPS through our 2022 acquisition of Affinivax. We’ve mainly directed MAPS at preventing pneumococcal disease, and it’s part of our 24-valent pneumococcal vaccine candidate in phase II development (see page 20). This platform also shows promise against other pathogens, including those that cause hospital-acquired infections. mRNA, which enables protein synthesis in the human body, carrying the information required for cells to produce proteins. By using mRNA technology for vaccine development, specific proteins, or antigens, can be produced by the body’s own cells and elicit both humoral and immune responses, enabling the human immune system to prevent or fight disease. We’re developing mRNA in-house in parallel with our collaboration with CureVac, a biopharmaceutical company developing therapies based on mRNA. We’re currently developing RNA vaccines based on CureVac’s second-generation mRNA backbone, with monovalent and bivalent COVID-19 vaccine candidates in phase II. A multivalent seasonal influenza vaccine candidate to protect against multiple strains is also in phase I/II (see page 20). Small molecule design, paired with our own small molecule generative AI tools. Our system has the advantage of using known chemical reactions and building blocks to create large 'virtual libraries' of potential drug molecules for specific biological targets. 27 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued The molecules comprising these virtual libraries have the advantage of being easily synthesised and free from many of the known problems associated with small molecule drugs since they are filtered by a series of machine-learned molecular property models based on GSK historical data and clean public sources. The combined power of biology and technology is profound and is reshaping the way science is done. For example, we now generate more data in one quarter than in our company’s 300-year history and, by the end of 2024, we aim to bring predictive, real-time insight to inform 90% of our progression and development decisions in our research. Oligonucleotides, which are short strands of DNA or RNA that can reduce, restore or modulate RNA through several mechanisms, giving them a unique capability to address a wide range of genomic targets in multiple therapeutic areas for the first time. Oligonucleotides currently in our pipeline include bepirovirsen for chronic hepatitis B; and GSK 4532990, a phase II programme for non-alcoholic steatohepatitis (NASH). We also have two collaborations to build a leading oligonucleotide platform: – In 2022, we entered a collaboration with Wave Life Sciences, which pairs our genetic expertise with Wave’s PRISM, the only oligonucleotide platform offering three RNA-targeting modalities (editing, splicing and silencing, including siRNA and antisense). The collaboration helps us accelerate drug discovery for newly identified targets, by matching them to the best therapeutic modality. – In 2023, we announced a partnership with Elsie Biotechnologies, Inc. The collaboration combines our expertise in DNA encoded library technologies with Elsie's drug discovery platform. Throughout the collaboration, we can exercise an option on a non- exclusive licence from Elsie for its discovery platform and P(V) chemistry technologies to use in our own oligonucleotide drug discovery research. Monoclonal antibodies, are produced by a single clone of cells or cell lines and consist of identical antibody molecules that are meant to modulate a patient’s immune system. We have all the platforms needed to make best-in-class monoclonal antibodies (like Nucala), bispecific antibodies, and antibody-drug conjugates (like Blenrep). We are also developing generative design capabilities based on increased use of next generation sequencing as well as public and proprietary protein structure tools. The structures designed using these tools are then realised using highly automated antibody synthesis, isolation, and purification processes. Adjuvants, substances that enhance the body’s immune response to antigens, which we use in Arexvy and Shingrix, our vaccines for RSV and shingles, and our HSV vaccine candidate, GSK 3943104. We are also working with Xiamen Innovax Biotech on a next-generation adjuvanted vaccine to protect against more types of HPV. Using genetic data to better understand disease and choose the right solutions for the right patients With data technology, we combine AI/ML with human genetics and functional genomics to understand patients, human biology and disease mechanisms. This makes us better at choosing and prioritising targets, designing trials and bringing new vaccines and medicines to patients. Combining AI, genetic and genomics for unexpected possibilities We have built in-house teams dedicated to genomics and AI, including at our key R&D sites in London, Tel Aviv, San Francisco, Seattle, Philadelphia and Boston. Their expertise helps us collect more data, generate more ideas and arrive at unexpected possibilities. They’re bringing us closer to finding vaccines and medicines for diseases that once felt outside our reach, making our research process faster, more effective, and more predictable. We have invested to build a world-class research data platform, which includes one of the world’s most comprehensive large language models on genetic disease. It brings over 700 billion data points into a single place to map gene expression and function activity. This enables our scientists to run experiments and get answers to questions in a matter of hours, a process that once took weeks or months. Genetics and genomics We are using a combination of genetics, functional genomics and genetic engineering techniques like CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) to enable us to screen and validate hundreds of genetic targets in parallel, instead of one at a time. Through the screening process we can discover causal genes through genomics and link to biomarkers that may predict disease. In 2023, we had 53 targets with strong genetic evidence in our pipeline, an increase from 45 in 2022. Applying data tech to our clinical research At the clinical stage of development, AI/ML and genomics are helping us assess how certain patient profiles might respond, so we’ll be able to make sure we have the right people in the right trials. This offers the potential to have shorter, less expensive clinical trials with greater chances of success. An example of this is our research on our antisense oligonucleotide bepirovirsen for chronic hepatitis B. Using ML, we developed algorithms that helped us categorise patients into five distinct subtypes based on their response to treatment. This almost doubled our ability to correctly predict future patient outcomes, compared to using the traditional methods. This is significant because it will help inform sequential and combination therapy options, potentially leading to better outcomes and ultimately helping more people living with hepatitis B experience functional cure. 28 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Collaborating to change the course of disease for patients By working with others we achieve more, better and faster to address disease areas of high unmet need and for as many people as possible. Our collaborations with UK Biobank, 23andMe and FinnGen have given us access to large genetic datasets to deepen understanding of diseases and improve drug discovery. We’re also a founding partner of Our Future Health, a UK initiative setting out to recruit up to five million people to capture genetic and medical information. And we work with Genes & Health and Discover Me South Africa to make sure we have a diverse genetic representation of diseases. In January 2024, we also announced we'd joined the Alliance for Genomic Discovery, further expanding our access to diverse genetic datasets. Other collaborations in functional genomics give us insights to help select targets that are more likely to become medicines. We continue to work with genomics research centres like the Broad Institute, affiliated with MIT and Harvard University in Boston, and the Altius Institute in Seattle. In the UK, our partners include the consortium Open Targets, which we co-founded. This work complements technology and biology projects underway at the Laboratory for Genomic Research, which we co-founded in 2019 with researchers at the University of California in San Francisco. These projects are automating and advancing CRISPR for new discoveries of disease mechanisms for immunology, oncology and neurology. Other collaborations are helping make advances in multiple fields of human health. – With King’s College London, we’re using tumour models alongside digital pathology and AI to develop personalised immuno-oncology treatments for solid cancers. – With PathAI, we’re working to accelerate R&D in oncology and NASH. – We established the Oxford-GSK Institute of Molecular and Computational Medicine (IMCM) with Oxford University in 2021. It combines human genetics with functional genomics and ML to focus on diseases including amyotrophic lateral sclerosis (ALS), Alzheimer’s and Parkinson’s. – Our work with precision medicine company Tempus has focused on using data to further enable clinical trial designs and target selections in oncology. Culture We create an agile, innovative environment that’s ambitious for patients and attracts the best people, scientists and partners. To get ahead of disease, we need the best people – scientists, researchers, trial specialists, technologists and more – and an environment where they can thrive and make the most of their expertise, inside the company or as partners. Our R&D people work together in an inclusive environment to foster new ideas and make connections, including our scientists, technologists and data engineers working side by side. 27% of our R&D leadership team started their roles in the past two years, bringing 56 years of combined experience, adding to our leadership and delivering against key priorities. Our culture unites us in being ambitious for patients and accountable for impact, and always doing the right thing. This culture encourages teams to focus on what matters most, take smart risks and make informed decisions at pace. It also helps them take ownership of objectives, seize opportunities and solve problems together. To support this, in 2023 we’ve taken steps to focus even more intently on our core therapeutic areas, strengthen decision-making with clearer ownership and simplified, agile governance, and embed technology more deeply in our work. We’ve created three research units dedicated to vaccines and infectious diseases, respiratory and immunology, and oncology. Reporting directly to the Chief Scientific Officer, they use their expertise to pick the right targets for the right patients, leading clinical development through to phase II and making recommendations on phase III programmes. These research teams complement our ongoing research in HIV, through ViiV Healthcare. Close collaboration between R&D, commercial, manufacturing and medical leaders makes sure we match scientific potential with unmet patient need to maximise our impact on disease and deliver competitive commercial value. We’ve also created one research technologies organisation, bringing together platform and data groups to create a scaled engine for identifying and progressing targets for ourselves and our partners. 29 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Research and development continued Pipeline overview We have 71 assets in development, of which 18 are late-stage. Phase III/Registration Arexvy (Recombinant protein, adjuvanted)1 RSV older adults (50-59 YoA)3 gepotidacin (BTI inhibitor)1 Uncomplicated UTI2 bepirovirsen (Antisense oligonucleotide)1 Chronic HBV infection2 Bexsero (Recombinant protein, OMV) Meningitis B (infants US) MenABCWY vaccine (Recombinant protein, OMV, conjugated vaccine) MenABCWY, 1stGen tebipenem pivoxil (Antibacterial carbapenem)1 Complicated UTI ibrexafungerp (Antifungal glucan synthase inhibitor)1 Invasive candidiasis Nucala (Anti-IL5 antibody) COPD depemokimab (Long-acting anti-IL5 antibody)1 Asthma2 latozinemab (Anti-sortilin antibody)1 Frontotemporal dementia2,4 camlipixant (P2X3 receptor antagonist) Refractory chronic cough Low carbon version of MDI5, Ventolin (Beta 2 adrenergic receptor agonist) Asthma6 Ojjaara/Omjjara (JAK1, JAK2 and ACVR1 inhibitor)3,7 Jemperli (Anti-PD-1 antibody)1 Endometrial cancer2 Zejula (PARP inhibitor)1 Ovarian cancer2 Blenrep (Anti-BCMA ADC)1 Multiple myeloma cobolimab (Anti-TIM-3 antibody)1 Non-small cell lung cancer linerixibat (IBAT inhibitor) Cholestatic pruritus in primary biliary cholangitis Phase II 3437949 (Recombinant protein, adjuvanted)1 Malaria fractional dose 4406371 (live, attenuated) MMRV new strain 3536852 (GMMA)1 Shigella 3528869 (Viral vector with recombinant protein, adjuvanted)1 Chronic HBV infection2,8 4023393 (Recombinant protein, OMV, conjugated vaccine) MenABCWY, 2ndGen8 4178116 (Live, attenuated) Varicella new strain 5101956 (MAPS)1 Adult pneumococcal disease, 24-valent 5101955 (MAPS)1 Paediatric pneumococcal disease, 24-valent 4106647 (Recombinant protein, adjuvanted)1 Human papillomavirus8 4348413 (GMMA) Gonorrhoea8 4382276 (mRNA)1 Seasonal flu 4396687 (mRNA)1 COVID-19 3993129 (Adjuvanted recombinant subunit) Cytomegalovirus8 3943104 (Recombinant protein, adjuvanted)1 Therapeutic herpes simplex virus8 5637608 (Hepatitis B virus-targeted siRNA)1 Chronic HBV infection 4077164 (Bivalent GMMA)1 Invasive non-typhoidal salmonella2 ganfeborole 3036656 (Leucyl t-RNA synthetase inhibitor)1 Tuberculosis sanfetrinem cilexetil (Serine beta lactamase inhibitor)1 Tuberculosis alpibectir BVL-GSK098 (Ethionamide booster)1 Tuberculosis 3810109 (Broadly neutralizing antibody)1 HIV 3739937 (Maturation inhibitor) HIV 4004280 (Capsid protein inhibitor) HIV 4011499 (Capsid protein inhibitor) HIV 4524184 (Integrase inhibitor)1 HIV9 Benlysta (Anti-BLys antibody) Systemic sclerosis associated interstitial lung disease 3858279 (Anti-CCL17 antibody)1 Osteoarthritis pain2 1070806 (Anti-IL18 antibody) Atopic dermatitis 4527226 (Anti-sortilin antibody)1 Alzheimer’s disease belrestotug (Anti-TIGIT antibody)1 Non-small cell lung cancer2 4532990 (HSD17B13 siRNA)1 Non-alcoholic steatohepatitis Phase I 3536867 (Bivalent conjugate)1 Salmonella (typhoid + paratyphoid A) 2556286 (Mtb cholesterol dependent inhibitor)1 Tuberculosis 3186899 (CRK-12 inhibitor)1,10 Visceral leishmaniasis 3494245 (Proteasome inhibitor)1 Visceral leishmaniasis 3772701 (P. falciparum whole cell inhibitor)1 Malaria 4024484 (P. falciparum whole cell inhibitor)1 Malaria 3882347 (FimH antagonist)1 Uncomplicated UTI 3923868 (PI4K beta inhibitor) Viral COPD exacerbations 3965193 (PAPD5/PAPD7 inhibitor) Chronic HBV infection8 5251738 (TLR8 agonist)1 Chronic HBV infection cabotegravir (Integrase inhibitor) HIV 3888130 (Anti-IL7 antibody)1 Autoimmune disease 3915393 (TG2 inhibitor)1 Pulmonary fibrosis 3862995 (Anti-IL33 antibody) COPD 5462688 (RNA-editing oligonucleotide)1 Alpha-1 antitrypsin deficiency 4347859 (Interferon pathway modulator) Systemic lupus erythematosus 4381562 (Anti-PVRIG antibody)1 Cancer 6097608 (Anti-CD96 antibody)1 Cancer XMT-205611 (STING agonist ADC)1 Cancer belantamab (Anti-BCMA antibody) Multiple myeloma 4524101 (DNA polymerase theta inhibitor)1 Cancer8 5733584 (ADC-targeting B7-H4)1 Gynecologic malignancies 4172239 (DNMT1 inhibitor)1 Sickle cell disease Assets are ordered by therapy area within each phase: infectious diseases, HIV, respiratory/immunology, oncology and opportunity driven. Only the most advanced indications are shown for each asset. (1) In-licence or other alliance relationship with third party (2) Additional indications or candidates also under investigation (3) In registration (4) Phase III trial in patients with progranulin gene mutation (5) Metered dose inhaler (6) Phase III start expected in 2024 (7) Approved in US and EU (8) In phase I/II study (9) Phase II study start imminent (10)Transition activities underway to enable further progression by partner (11) GSK has an exclusive global licence option to co-develop and commercialise the candidate RSV: respiratory syncytial virus; UTI: urinary tract infection; HBV: hepatitis B virus; ADC: Antibody drug conjugate; COPD: chronic obstructive pulmonary disease; MMRV: measles, mumps, rubella & varicella; OMV: outer membrane vasicle; siRNA: small interfering RNA GMMA: generalised modules for membrane antigens; YoA years of age 30 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Commercial operations In 2023 we delivered strong and sustained performance momentum, with successful commercial launches, supported by our integrated global supply chain. 31 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Commercial operations Highlights £30.3bn +3% total sales AER +5% CER +14% CER excluding COVID Sales contribution by product area (£bn)1 Sales contribution by region (£bn)1 +24% +15% +5% +10% +14% +16% +8% +15% +10% +14% l Vaccines l Speciality Medicines l General Medicines l US l Europe l International (1) Bar charts: excluding COVID-19 solutions Absolute values at AER; changes at CER, unless stated otherwise Strong operational performance In 2023 we've continued to focus on operational performance, with strong growth across all product areas and regions. This builds on good progress in 2022 and demonstrates strong, sustained performance momentum. It means we are confident in delivering our upgraded growth outlooks for the period 2021-26, and for 2031. Strong performance in 2023 was driven by a continued step-change in commercial execution. This was underpinned by a focus on leadership, developing outstanding people, and building meaningful connections with healthcare professionals (HCPs) and patients – supported by data and technology – to give us strong insights into how we can best meet their needs. For details on our performance and drivers of growth see: – Vaccines performance, page 33 – Specialty Medicines performance, page 37 – General Medicines performance, page 40. 32 202220230102030202220230102030 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Vaccines Our broad vaccines portfolio targets infectious diseases at every stage of life, helping to protect people from meningitis, shingles, RSV, flu, polio and many more. Turnover £9.9bn +24% AER, +25% CER l Established £3.3bn l Shingles £3.4bn l Meningitis £1.3bn l RSV £1.2bn l Influenza £504m l Pandemic £150m Double-digit growth for Vaccines Successful launch of Arexvy in the US Continued strong uptake of Shingrix in International and Europe 33 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Vaccines continued Key products Product Shingrix Arexvy Bexsero Boostrix Rotarix Disease Total revenue Key information Herpes zoster (shingles) £3.4bn +16% AER; +17% CER RSV £1.2bn Meningitis group B £849m +13% AER; +14% CER Market-leading recombinant, adjuvanted vaccine indicated for the prevention of shingles in adults. Launched in 40 markets World's first approved RSV vaccine for adults, approved in 39 countries Approved in over 50 countries for the prevention of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup B Diphtheria, tetanus, acellular pertussis booster £614m +3% AER; +4% CER Available in 78 countries and market leader in the US Rotavirus £614m +17% AER; +18% CER Market-leading pediatric vaccine in 132 countries. Increased share in the US since launch of liquid formulation in 2022 Fluarix, FluLaval Seasonal influenza £504m -29% AER; -29% CER Quadrivalent influenza vaccines, available in 38 countries Infanrix, Pediarix Diphtheria, tetanus, pertussis, polio, hepatitis B, haemophilus influenza type B £554m -7% AER; -6% CER DTPa vaccine available in 77 countries. Pediarix is one of the leading brands by volume in the US Engerix, Twinrix, Havrix Hepatitis £611m +7% AER; +8% CER Growing hepatitis portfolio leadership through increased coverage and strengthened recommendations £380m +10% AER; +12% CER Menveo helps protect against IMD caused by Neisseria Menveo Synflorix Priorix, Priorix Tetra, Varilrix Meningitis group A, C, W and Y Invasive disease, pneumonia, acute otitis media Measles, mumps, rubella and chickenpox £275m -10% AER; -10% CER £265m +41% AER; +41% CER Cervarix Human papilloma virus £120m +3% AER; +5% CER meningitidis serogroups A, C, Y and W and is available in over 60 countries Synflorix, available in 100 countries, including WHO pre- qualification. Acquisition of MAPS technology is expected to enable greater serotypes and disease coverage Priorix continues to gain share in the US. Priorix is available in 97 countries, Varilrix in 86 countries, and Priorix Tetra in 60 countries An important option against HPV. Cervarix two-dose schedule for girls aged 9-14 launched in China in 2023 Sales performance Vaccines sales grew 24% AER, 25% CER to £9.9 billion total and 23% AER, 24% CER to £9.7 billion excluding COVID-19 solutions. Shingrix grew 16% AER, 17% CER to £3.4 billion on increased demand and favourable pricing, with Q4 2023 representing the highest ever quarter of sales. Growth was driven by public funding expansion and strong private uptake in International and Europe. Meningitis vaccine sales grew 13% AER ,14% CER to £1.3 billion, largely delivered by Bexsero, primarily driven by inclusion in National Immunisation Programmes in Europe. Menveo grew due to the favourable impact of a US CDC (Center for Disease Control) stockpile replenishment. Arexvy achieved more than £1.2 billion in sales driven by strong uptake and leading market share, delivering an outstanding launch. Almost all sales were in the US where Arexvy is available in all major retail pharmacies with competitive contracting in place. Influenza (Fluarix/FluLaval) sales declined in line with expectations by 29% at AER and CER, to £504 million. This was driven by competitive pressure and lower market demand, primarily in the US. Established Vaccines grew 6% AER, 7% CER to £3.3 billion driven by Rotarix favourable US CDC stockpile movements, MMR/V vaccines increased supply in International, and hepatitis vaccine performance related to the travel market recovery. 34 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Vaccines continued Our strategy for growth Our portfolio of more than 20 marketed vaccines is one of the industry’s broadest. We deliver approximately 1.5 million doses of our vaccines every day; and 4 out of 10 infants born each year receive at least one GSK vaccine. Our vaccines portfolio targets infectious diseases at every stage of life, helping to protect people from RSV, meningitis, shingles, flu, polio and many more. Vaccines are critical to delivering our growth plans. Our focus is on strong execution in key markets with Shingrix and our existing portfolio, and on delivering the value of our pipeline with new launches, particularly our world-first RSV vaccine, Arexvy, so we can bring our vaccines to as many patients as possible. Vaccines are complex and highly technical to develop and manufacture. This helps to protect our portfolio from potential disruption from new technologies. There’s no established generic industry and vaccines don’t generally face the so-called ‘patent cliff’. This longer lifecycle means vaccines can remain in use for decades after their initial authorisation. For example, Boostrix, Infanrix, Priorix and Engerix remain important parts of our portfolio in terms of contribution to performance. Our established platform technologies, and the new platforms we’re building, such as the MAPS and mRNA technologies, are a key part of our vaccines growth strategy and are enabling us to tackle the most complex diseases from birth throughout adulthood (see page 27). Drivers of growth across the portfolio Our launch of Arexvy supports our market leadership ambition and has multi-billion-pound sales potential. Approximately 6 million of the 83 million US adults aged 60 and older at risk have been vaccinated with Arexvy. Launches are also underway across Europe and Canada, and the vaccine has been approved in Japan and several other countries. We’re strengthening relationships with retailers, given our expertise in the older adult population through Shingrix. We’re also drawing on our expertise in respiratory diseases and the experience of our primary care sales force. With further approvals and launches expected in 2024, and increasing awareness of the impact of RSV on adults at increased risk, we look forward to seeing the impact this vaccine will have on helping to prevent the severe consequences of RSV globally. Shingrix continued to grow and is now available in 40 countries, with less than 4% penetration in the majority of those markets. In the US 35% of the 120 million adults recommended to receive Shingrix have now been vaccinated. 70 million people are already protected with Shingrix and our ambition is to vaccinate more than 100 million people by 2026. To support this, in 2023 we entered into an exclusive agreement with Chongqing Zhifei Biological Products, Ltd. (Zhifei) with a value of £2.5 billion for an initial three-year period to co-promote Shingrix in China. Zhifei will import and distribute Shingrix in China, promoting the vaccine through its network of over 30,000 vaccination points. The partnership will significantly extend the availability of Shingrix, supporting the rapid expansion of patient access to the vaccine and future potential indications. We continue to lead the meningitis market driven by Bexsero (MenB) and Menveo (MenACWY), as we prepare for the transition to our pentavalent MenABCWY vaccine that combines these established vaccines. Continuing to invest in Bexsero remains integral to strengthening our leadership by securing key National Immunisation Programmes (NIP) in countries like Germany and Switzerland. We’ll do this by building our real-world evidence base, and by helping to improve immunisation rates globally, focusing on the US adolescent population. To improve our competitiveness, we’ll look to drive future growth with multiple lifecycle innovations in the coming years, including launching Menveo in a convenient liquid formulation in additional countries. Our established vaccines remain a key priority for growth, representing a third of our total vaccines business. Our core vaccines continue to grow strongly as we seek to maximise uptake in those who need them. We achieve this by prioritising specific segments for growth opportunity, such as a return to travel and strengthened recommendations for hepatitis in the adult segment, and increasing awareness of the importance of vaccination. We’re also working to maintain our strong performance in key markets by making sure we resource our teams for success and that we can deliver against our supply commitments. Meeting the needs of ageing populations by prioritising prevention By focusing on prevention, we can reduce the burden of disease and create a healthier, thriving world. Vaccination is a critical element for prevention of infectious diseases, especially for children and older adults. From the age of around 50, our immune system starts to decline and becomes less effective, leading to increased risk from infectious diseases. We focus our efforts on helping to keep older adults healthy, moving from ‘sick care’ to true healthcare by prioritising prevention and making adult immunisation the standard of care. With the help of vaccination, adults can remain active, healthy participants in society and the economy – prolonging productivity, contributing to local economies and reducing healthcare costs. To improve uptake of adult immunisation, we are working to build the investment case for vaccination, ease access, and increase belief in the importance of vaccines. 35 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Vaccines continued To support healthcare professionals to routinely initiate vaccination conversations with their patients and build broader belief in the importance of vaccination, we held Vaccine Virtual Days 2023. These bring together healthcare professionals and experts from the international vaccine community to discuss and present important updates, data and trends in adult immunisation. We’ve also continued our series of Vaccinology Master Classes, helping to better equip healthcare professionals for conversations with their patients about vaccines. Adult immunisation rates in the US still haven’t recovered fully after the COVID-19 pandemic. In 2023, we commissioned a report, published with the IQVIA Institute for Human Data Science and the Global Coalition on Aging. It estimated that around 100 million fewer doses of some adult vaccines (excluding COVID-19 solutions) were administered in 2021 and 2022 than anticipated. To help address this, we launched the COiMMUNITY Initiative in the US which commits $1 million in grant funding to national, state and local non-profit organisations to address long-term barriers to immunisation, particularly among older adults susceptible to declining immune systems. This year we commissioned research that spotlights hyperlocal factors contributing to – or inhibiting – adult immunisation uptake in five diverse, geographically representative cities across the world. This research builds upon existing global frameworks and progresses vital initiatives, such as the UN Decade on Ageing and WHO Age-Friendly Cities Network. As part of COiMMUNITY, we’re also supporting public health efforts by making data on vaccination trends available through the Vaccine Track platform and sharing tools and resources with healthcare organisations to help them address gaps in adult immunisation. The COiMMUNITY initiative builds on recent regulatory and industry changes in the US that make vaccines more available and easier to access for Medicare and Medicaid beneficiaries and support community vaccine infrastructure. 36 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Specialty Medicines Specialty Medicines growth (excluding COVID-19 solutions) of 14% AER, 15% CER Continued growth momentum in HIV Growth acceleration in both oncology and respiratory/immunology We continue to be global leaders in infectious diseases, respiratory and HIV medicines and have an emerging portfolio of cancer medicines. Turnover £10.2bn -9% AER, -8% CER l HIV £6.4bn l Respiratory/immunology and other £3.0bn l Oncology £731m l Pandemic £44m 37 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Specialty Medicines continued Key marketed products Product Dovato Nucala Disease Total revenue Key information HIV treatment £1.8bn +32% AER; +33% CER Dolutegravir-based two-drug regimen. Now launched in over 55 markets Respiratory eosinophil- driven diseases £1.7bn +16% AER; +18% CER The only treatment to be indicated in the US and Europe for use across four IL-5 mediated diseases (see page 23) Triumeq HIV treatment £1.5bn -14% AER; -14% CER Tivicay HIV treatment £1.4bn flat% AER; +2% CER Benlysta Lupus and lupus nephritis £1.3bn +18% AER; +19% CER Dolutegravir-based fixed-dose combination tablets. Marketed in over 65 countries Dolutegravir tablet for use in combination with other antiretroviral agents. Marketed in over 70 countries Only biologic approved to treat both SLE and LN, in the US, Europe and elsewhere Cabenuva (Vocabria + Rekambys in Europe and Japan) HIV treatment £708m >100% AER;>100% CER First and only complete long-acting injectable regimen (cabotegravir, rilpivirine). Marketed in over 25 countries Juluca Zejula HIV treatment £661m +4% AER; +4% CER Ovarian cancer £523m +13% AER; +15% CER Dolutegravir-based two-drug regimen. Marketed in 30 countries PARP inhibitor commercially available in 1L maintenance in 37 markets and in 2L maintenance in 31 markets Apretude HIV prevention £149m >100% AER; >100% CER First and only long-acting injectable (cabotegravir) for HIV prevention. Launched in the US in 2022 Jemperli Endometrial cancer £141m >100% AER; >100% CER PD-1-blocking antibody available in 25 countries that is Rukobia HIV treatment £117m +43% AER; +44% CER continuing to be investigated for future monotherapy and combination regimens in multiple tumour types Extended-release tablets for people living with multi-drug resistant HIV-1 for use in combination with other antiretrovirals. Launched in 16 markets Xevudy Blenrep COVID-19 treatment £44m -98% AER; -98% CER Monoclonal antibody for the early treatment of COVID-19 Blood cancer – multiple myeloma £36m -69% AER; -69% CER An antibody-drug conjugate for patients with relapsed or refractory multiple myeloma Ojjaara/Omjjara Myelofibrosis £33m Approved in the US, EU and UK as the first and only treatment specifically indicated for myelofibrosis patients with anaemia Jesduvroq/Duvroq Anaemia due to chronic kidney disease (CKD) £26m 18% AER; 27% CER Approved in the US in 2023 for the treatment of anaemia of chronic kidney disease (CKD) in adult patients on dialysis Sales performance While reported Speciality Medicines sales were down 9% AER, 8% CER at £10,224 million total, excluding COVID-19 solutions they grew 14% AER, 15% CER at £10,200 million. HIV sales grew 12% AER, 13% CER to £6.4 billion, primarily driven by a 2 percentage point increase in market share within a broadly flat global treatment market, attributable to patient demand for the oral two-drug regimen (Dovato, Juluca) and long-acting medicines (Cabenuva, Apretude). Oral two-drug regimen and long-acting medicine sales grew 40% to £3.3 billion now representing 55% of the total HIV portfolio. Respiratory/immunology and other sales were up 16% AER, 18% CER to £3 billion with consistent and sustained double- digit growth for both Benlysta and Nucala. Nucala grew 18% to £1.7 billion with continued strong growth in all regions reflecting high patient demand in severe eosinophilic asthma and from the new indications. Benlysta grew 19% to £1.3 billion representing strong demand in US and Europe and continued market expansion. Oncology sales grew 23% to £731 million, driven by strong growth from Jemperli and Zejula and uptake of Ojjaara post US launch in Q3 2023, partially offset by the impact of Blenrep withdrawal from the US market in November 2022. Growth of Jemperli continued to accelerate particularly in the US following approval in Q3. Zejula sales grew 15% to £523 million with strong growth from all regions. US growth in the first line indication more than offset the reduction in use in second line following the update to US prescribing information agreed with the FDA in Q4 2022. 38 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: Specialty Medicines continued Our strategy for growth Our portfolio of Specialty Medicines focuses on four therapeutic areas: infectious diseases, HIV, respiratory/ immunology and oncology. We are reinforcing our strength and leadership in infectious diseases, respiratory and HIV, and building our emerging capabilities in oncology to drive growth. 34% of sales come from Specialty Medicines, which we expect to provide durable and profitable growth over the next five years. We drive growth by accelerating our pipeline as well as prioritising business development, targeting acquisitions and partnerships to strengthen and complement our core therapy areas, and helping to deliver above and beyond our current long-term outlooks. Our acquisition of Bellus Health, announced in April 2023, for example, builds on our respiratory expertise and complements our broader respiratory pipeline. We’re increasingly confident that this will be a major source of new long-term growth. Drivers of growth across the portfolio In HIV, our strategy for growth is built on our innovative portfolio of medicines that are transforming HIV treatment and prevention with strong competitive execution. Launched in 2019, our dolutegravir-based oral two-drug regimen, Dovato, continues to perform strongly, enabling people living with HIV to remain virally suppressed with fewer medicines. Our long-acting portfolio of medicines are central to our growth and are delivering strong results as they launch across our markets. Cabenuva, the world’s first and only complete long-acting regimen for HIV treatment is available in the US, Europe, Japan, China and Australia. Two-monthly Cabenuva addresses the challenges associated with daily oral therapy, including fear of disclosure, adherence anxiety and pill fatigue. Apretude is the world’s only long-acting medicine for HIV prevention offering superior efficacy to daily oral prevention (FTC/TDF tablets) and two-monthly dosing. In 2023 Apretude expanded beyond the US with approval in Europe and several sub-Saharan Africa countries as an important lever to end the global epidemic. In respiratory/immunology, our market-leading medicines Nucala and Benlysta continued to deliver double-digit growth. Nucala, the only targeted biologic therapy approved for use across four IL-5 mediated diseases (eosinophil disease), continues to drive growth. Consistent evidence across multiple indications combined with market-leading safety data reinforce Nucala as the biologic of choice for HCPs. The severe asthma market continues to grow in the US and in other markets, which offer opportunities for Nucala to help more patients. Benlysta remains the only biologic approved for both systemic lupus erythematosus and lupus nephritis In 2023, Benlysta saw consistent growth across all major markets, with over 14,000 US patients starting therapy in 2023. We’re focused on helping to identify and treat patients earlier, before lupus progresses and organ damage occurs (see page 24). In oncology, Jemperli continues to demonstrate its potential as the backbone of our ongoing immuno-oncology-based research and development programme. Used alone and in combination with standard of care and future novel cancer therapies, it has the potential to transform patients’ lives across multiple tumour types, including endometrial cancer. In 2023, Jemperli plus chemotherapy was approved in the US, EU and UK as the first and only immuno-oncology regimen for the treatment of frontline primary advanced or recurrent dMMR/MSI-H endometrial cancer. These approvals have been a significant driver of performance and sales growth in oncology. Ojjaara/Omjjara, a JAK- and ACVR1-inhibitor, acquired through the purchase of Sierra Oncology in April 2022, is now approved in the US, EU and UK to treat myelofibrosis with anaemia. This makes Ojjaara the only medicine specifically indicated for both newly diagnosed and previously treated myelofibrosis patients with anaemia that addresses the anaemia, constitutional symptoms and splenomegaly (enlarged spleen) that are the hallmarks of this complex blood cancer. The line-agnostic label was broader than anticipated, expanding the opportunity to reach more patients with a novel treatment option. Additional regulatory filings were initiated in 2023, with an aim in 2024 to expand access to patients in other markets. In ovarian cancer, Zejula continues to provide a significant opportunity for first-line maintenance therapy, reaching more than 15,000 patients every month. We’re working to develop other combination therapies with Zejula in women's cancers and other solid tumours. To ensure we focus on areas where we can make the biggest impact for patients, we’ve withdrawn our filing for Jesduvroq in the EU, and will stop filing in other markets because other medicines are already available for patients living with anaemia of CKD. 39 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: General Medicines From antibiotics to inhaled medicines for asthma and COPD, we have over 150 general medicine products, many of them leaders in their class, making life better for millions of people worldwide. Turnover £10.2bn +1% AER, +5% CER l Respiratory £6.8bn l Other General Medicines £3.4bn Growth driven by both respiratory and other general medicines Ongoing strong demand for Trelegy in all regions; Anoro in Europe and International Continued post pandemic recovery of the antibiotic market in Europe and International regions 40 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Performance: General Medicines continued Key marketed products Product Disease Total revenue Key information Trelegy Ellipta COPD, asthma £2.2bn +27% AER; +29% CER Most prescribed single inhaler triple therapy (SITT) worldwide, Seretide/Advair Asthma, COPD £1.1bn -2% AER; +1% CER Relvar/Breo Ellipta Asthma, COPD £1.1bn -4% AER; -2% CER reaching an estimated 8.6 million patients since launch One of the market-leading ICS/LABA1 treatments worldwide by sales value One of the leading ICS/LABA treatments worldwide by sales value Asthma, COPD £749m -3% AER; — CER Global market-leading SABA2 reliever by sales value Ventolin Augmentin Common bacterial infections £628m +9% AER; +17% CER Anoro Ellipta COPD £557m +15% AER; +16% CER Avodart & Duodart Benign prostatic hyperplasia (BPH) £345m +5% AER; +7% CER Avamys/Veramyst Allergic rhinitis £299m -7% AER; -4% CER Global leader in oral antibiotics by sales value, available in over 95 countries Global market leader in the LAMA/LABA3 class by volume (unit sales), approved in over 70 countries Market leaders by sales value in the global dutasteride and dutasteride+tamsulosin FDC4 market respectively, and approved in over 101 and 88 countries respectively Global leader in the inhaled corticosteroids prescription class by sales value Dermovate, Betnovate, Cutivate, Eumovate Inflammatory skin conditions £195m -3% AER, +6% CER Global leader in topical corticosteroids across 60 markets globally by value of sales, excluding the US (1) ICS/LABA: inhaled corticosteroid/long-acting beta agonists (2) SABA: short-acting beta agonist (3) LABA/LAMA: long-acting beta agonists/long-acting muscarinic antagonists (4) FDC: fixed-dose combination Key information source IQVIA Sales performance General Medicines sales grew 1% AER, 5% CER to £10.2 billion, reflecting growth of Trelegy and the single inhaler triple therapy class across all regions, and of Anoro in Europe and International. Trelegy grew 27% AER, 29% CER to £2.2 billion with growth delivered across all regions, reflecting increased patient demand, growth of the SITT market and penetration of the class. Seretide/Advair sales decreased 2% AER but increased 1% CER at £1.1 billion, primarily reflecting favourable US pricing. However this was offset by generic erosion impacts in Europe and certain International markets. Other General Medicines decreased 5% AER, but grew 2% CER at £3.4 billion reflecting ongoing post pandemic demand for anti-infectives in Europe and International, and certain third party manufacturing arrangements. Overall growth in this product group continues to be impacted by ongoing generic competition. Our strategy for impact Our General Medicines portfolio includes medicines that are typically prescribed in primary care. In 2023, General Medicines contributed over one third of GSK's sales, helping to fund growth and investment in R&D and returns to shareholders. We expect our combination of more than 150 products, several of which are market leaders, to have a positive impact on the lives of hundreds of millions of patients over the next 10 years. We supply our products in more than 100 countries, and they comprise over 80% of our total medicines and vaccines supply volume. Every day, these medicines improve health and make life better for millions of people all over the world. Together, respiratory and infectious diseases therapeutics generate 73% of our General Medicines revenue. With expected growth from Trelegy, Anoro and the established products portfolio in emerging markets, we are committed to positively impacting more lives every day. We focus investment in our brands that are growing strongly to maximise returns, while managing the expected decline of other products in mature markets as they lose their exclusivity. 41 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Augmentin is a global leader in oral antibiotics by sales value4 and is available in 95 countries. It has reached over 2.65 billion patients since launching more than 40 years ago and continues to grow strongly across regions. Augmentin grew 9% AER, 17% CER to £628 million with strong ongoing demand across all regions. Since its launch in 1969, Ventolin remains an important medicine for patients in more than 100 countries. A significant proportion of our carbon emissions come from our Ventolin metered dose inhalers (MDIs). We have started an R&D programme to redevelop our Ventolin MDIs with a lower global warming potential (GWP) propellant, which is now in clinical assessment. If successful, this could reduce greenhouse gas emissions from our rescue MDIs by approximately 90%. Performance: General Medicines continued Drivers of growth across the portfolio Our main sources of growth in General Medicines in 2023 were Trelegy, Anoro and Augmentin. Trelegy, our SITT for asthma and COPD, delivered sales of over £2 billion for the first time in 2023. Trelegy has continued to accelerate strongly, with growth in all regions including the US, and is the third biggest growth driver in our portfolio. Trelegy is licensed in 60 countries for COPD, with dual indications for asthma and COPD in 19 countries, including the US and Japan1. We received several new approvals in 2023, further expanding Trelegy’s availability to asthma patients in Turkey, Hong Kong, Bahrain and Kuwait.2 Trelegy is the number one SITT globally, selling over 21 million packs – more than twice the volume of the nearest competitor3. Trelegy is the market leader in our two largest markets, the US and Japan, with market shares significantly exceeding the next-largest competitor (83% and 67%, respectively). In November 2022, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommended triple therapy over ICS/LABA for exacerbating patients. This has helped to continue the growth of the SITT market which, six years after first launch, is still growing at 41% year on year. We expect Trelegy to be a key driver of growth in General Medicines in the coming years. Anoro is approved in approximately 70 countries to treat symptomatic COPD. Anoro remains the global market leader in the LAMA/LABA class by volume (unit sales)4, with continued growth in global sales (excluding US). Anoro has a robust clinical data profile, which includes head-to- head data in the LAMA/LABA class and versus other common initial maintenance therapy options, such as LAMA. (1) Regulatory Data on File. Latest update 25 August 2023 for Asthma and July 2022 for COPD (2) Regulatory Data on File, Latest update 25 August 2023 (3) IQVIA Patient Volume Data as of 6 October 2023 (4) Source: IQVIA 42 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Operations: Manufacturing and supply Our global supply chain is critical to the successful manufacture and supply of our vaccines and medicines. It enables us to deliver reliable, high-quality products to meet patients’ needs and maintain our performance. In 2023, we made significant progress in bringing together our vaccines and medicines supply chains to create one global supply chain. This integration helps drive efficiency and ensures we have the capacity and capabilities, including the best digital and technology capabilities, to deliver our new products. Our global network of 37 vaccines and medicines manufacturing sites delivered more than 500 million vaccine doses and 1.8 billion packs of medicines to help make a positive impact on the health of millions of people. Investing for future productivity We are investing in our manufacturing and supply chain to increase productivity and efficiency. In 2023 we opened a $100 million adjuvant manufacturing facility in Hamilton, in the US. It means we can produce the QS-21 adjuvant in-house, contributing to our RSV, shingles, malaria and cervical cancer vaccines. In late 2022, we opened a manufacturing and testing facility at Jurong in Singapore to produce a cytotoxic agent for antibody drug conjugates needed for next-generation cancer treatments. And at our Tuas site, also in Singapore, we’ve begun building a new vaccine manufacturing facility for our hepatitis B vaccines which will feature the latest advanced technology and be sustainable by design. 43 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Operations: Manufacturing and supply continued At Ware in the UK, we opened a new oral solid dose facility, bringing together R&D and supply chain specialists to use new technologies and rapid knowledge transfer to deliver new medicines faster and more efficiently. And at our Wavre site in Belgium, we’ve started building a €250 million freeze-drying centre, using automation and robotics, to create more capacity for adult vaccines. At Barnard Castle in the UK, our multi-million-pound Q Block smart manufacturing facility started commercial production in 2023, and immunology products are now being shipped to patients around the world. The facility uses digital technology and robotics to make production more efficient. We are exceeding targets in our ongoing programme of productivity and efficiency improvements. This year, the programme delivered £101 million in savings across Medicines and Vaccines. Site productivity increased by 9.3% during the year. Promoting quality, safety and reliability Quality, safety and reliable supply are critical to meeting patients’ needs, and to creating competitive advantage. Our reliability remains strong, with an on-time, in-full (OTIF) measure of 99.3% for Specialty Medicines, 98.4% for General Medicines and 92.3% for Vaccines. Our deviation rates improved for Medicines and increased marginally for Vaccines with clear action plans for improvement in 2024. For information on product governance, see the Responsible Business section on page 55. We’ve also received external recognition. In 2023, we featured in Gartner’s Top 25 Supply Chain companies, based on financial metrics, ESG criteria, and opinion from industry analysts and experts. Supporting innovation Our global supply chain plays a central role in bringing our innovations to patients as quickly, efficiently and effectively as possible. The teams are involved early in product development, working with R&D to make sure that what works in clinical trials can be produced commercially at scale. In 2023 we supplied our RSV vaccine Arexvy in record time to more than 20 countries, including the US, the EU and Canada, following regulatory approvals. We are also bringing on additional capacity to deliver Jemperli to more patients around the world following regulatory approvals in the US and Europe. And we worked with external manufacturing partners to deliver supply chain excellence for the US launch of Ojjaara. Embracing technology and data By harnessing the power of technology and data, we are transforming our manufacturing and supply chain. By identifying and implementing the best digital and technology capabilities, we can unlock growth for patients, shareholders and our people. We are also working to industrialise new platform technologies such as oligonucleotides in medicines and mRNA and MAPS in vaccines. As MAPS clinical trials continue at the new Binney Street site in Cambridge, US, we plan to scale up production and bring MAPS to market. We’re using digital twins to simulate processes, anticipate issues and use what we learn to accelerate manufacturing. The technology helps increase production yields for both our vaccines and medicines. We’re also investing in automation and robotics at our sites, improving ergonomics, increasing efficiency and helping us to deliver more medicines and vaccines to patients around the world. Increasing our environmental sustainability Our manufacturing sites have a key role in our contribution to a net zero, nature positive, healthier planet, and environmental sustainability is a fundamental part of our global supply chain strategy. See our Responsible Business section on page 45 for more information on carbon emissions, water use and waste. We’re also investing in plans to improve natural habitats, protect biodiversity and improve soil and water quality near our sites. + For more on our approach to sustainability and progress made at our sites, see our ESG Performance Report 44 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business ESG is embedded in our strategy. It helps us deliver our purpose and supports our sustainable performance and long-term growth. 45 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business Our approach We are a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. To deliver our purpose, we need to consider ESG impacts across everything we do, from the lab to the patient. That’s why ESG is embedded in our strategy and supports our sustainable performance and long-term growth. It helps us to build trust with and generate value for our stakeholders, reduce risk to our operations and create positive social impact. We have identified six ESG focus areas that address what is most material to our business and the issues that matter the most to our stakeholders. These focus areas are core to our strategy and are where we can have the greatest positive impact on some of society’s most urgent challenges, including those set out in the UN Sustainable Development Goals (UN SDGs). They are: – Access to healthcare – Global health and health security – Environment – Diversity, equity and inclusion (DEI) – Ethical standards – Product governance. These focus areas were informed by our most recent materiality assessment in 2022, which reaffirmed that the most material issues for our business were well aligned with our six ESG focus areas. We recognise that being a responsible business is not a static requirement. This means that we will continue to evolve our approach in response to the rapidly changing operating environment and strive for continuous improvement to ensure we maintain strong ESG performance. Our ESG Performance Rating Our ESG Performance Rating helps us integrate ESG into the delivery of our strategy and allows us to measure and verify the progress we are making. The rating is one of our corporate KPIs and measures progress against key metrics aligned to each of our six focus areas. In 2023, this included 22 metrics, which are summarised in our ESG Performance Report. 2023 ESG Performance Rating Our 2023 ESG Performance Rating is on track, based on 95% of all performance metrics being met or exceeded. We continue to evolve our ESG Performance Rating to ensure it meets the expectations of our stakeholders. The executive leadership team and the Board, via the Corporate Responsibility Committee, review the metrics that make up this Rating each year to ensure they are sufficiently challenging and ambitious. This year, we have removed two metrics, relating to Access and Ethical standards, and added one relating to anti-microbial resistance (AMR). We met one of our 2022 metrics relating to Access by developing and publishing pricing and access principles. We have also removed one of our Ethical standards metrics that tracks the number of employees leaving GSK for misconduct. Increases or decreases in this number could indicate either a higher/ lower number of breaches or stronger/weaker enforcement of our processes, so setting a threshold is not an effective measure for success in upholding our standards. We continue to monitor this data internally and publish it externally. We have three additional metrics which provide a strong measure of our commitment to ethical standards. We have added a metric within Global health and health security, focused on AMR. AMR is an urgent public health threat, and we have seen increased stakeholder interest in our approach. We updated our biodiversity target as we achieved it in 2022. Our new target focuses on deforestation free sourcing of paper and palm oil. How we assess performance The GSK Leadership Team (GLT) is accountable for delivering progress against the metrics and regularly reviews performance along with the Board’s Corporate Responsibility Committee (CRC). Each individual metric is assessed as either: on track (metric met or exceeded); on track with work to do (at least 80% of metric has been achieved); or off track (metric missed by more than 20%). In addition, in order to calculate the overall ESG Performance Rating, performance across all metrics is aggregated to a single score to illustrate whether we are on track, on track with work to do, or off track. This rating is defined below: On track: 70% or more of all metrics are on track On track with work to do: more than 50% of all metrics are either on track, or on track with work to do Off track: more than 50% of all metrics are off track Assessment of performance against our annual targets has been reviewed, and the overall ESG Performance Rating score has been subject to independent limited assurance for 2023. + For full details of progress against our six focus areas, our ESG Performance Rating and 22 metrics and independent limited assurance reports, see our ESG Performance Report 46 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued External benchmarking Detailed below is how we perform in key ESG ratings that we are frequently asked about by investors: – Access to Medicines: Ranked 1st in the Access to Medicines Index in 2022 and an industry leader in the 2021 Antimicrobial Resistance Benchmark – S&P Corporate Sustainability Assessment: Ranked 1st in the pharmaceuticals industry with a score of 84 (as of 24 November 2023) and included in the DJSI World and Europe indices – FTSE4Good: Member of FTSE4Good Index since 2004 – CDP: A- in Climate change, A- in Water security, B in Forests (palm oil) and B in Forests (timber) – Sustainalytics: Low risk rating – MSCI: AA rating – Moody's Analytics: ESG Overall Score of 62 (out of 100; sector average 38) – ISS Corporate Rating: B+ rating Access We aim to positively impact the health of 2.5 billion people by the end of 2030. We will do this by making our vaccines and medicines available as widely as possible, through responsible pricing, strategic access programmes and partnerships. Our commitment Make our products available at value-based prices that are sustainable for our business and implement access strategies that increase the use of our medicines and vaccines to treat and protect underserved people Our ESG Performance Rating metric – Progress towards our 2030 goal of reaching 1.3 billion people in lower income countries with our products Progress in 2023 Putting the right value on innovation We set responsible prices in line with the benefits we bring to patients and health systems, measured by clinical, economic and social outcomes. We compare our offer to what is already available for patients and we generate evidence from clinical trials to establish the added value provided by our medicines and vaccines. We adjust our pricing in line with the socio-economic status of a country to ensure affordability and availability. We operate under robust pricing approvals, developing access plans informed by payers. We also work to create stability and predictability for payers and our business, engaging proactively on upcoming product launches for budget planning, and adjusting prices to account for inflation. In the US in 2023, our combined average net price (after discounts, rebates or other allowances) for our pharmaceutical and vaccines portfolio increased by 0.4%, while the average list price increased by 3.2%, compared with 5.4% (list) for the industry. Over the past five years, the average net price for our products increased by 0.3% annually, while the average list price rose by 3.3%, compared with 4.7% (list) for the industry. Providing access for patients in lower income countries We collaborate with global health partners, including NGOs and generic manufacturers, to increase our reach to patients in lower income countries. In 2023, we reached 89 million people with our vaccines and antiretrovirals in lower income countries. Vaccines We reserve our lowest vaccine prices for Gavi, the vaccine alliance, and similar organisations. We have partnered with Gavi since its foundation in 2000 and have supplied more than one billion vaccine doses to date at our lowest prices to the lowest income countries. In 2023, through our partnership we significantly increased our supply to deliver around 5 million doses of Cervarix, a critical vaccine in lower income countries for addressing cervical cancer. In 2023, we supplied around 41 million doses of our pneumococcal vaccine, Synflorix, to eight Gavi-eligible countries at our lowest price. Our vaccine against rotavirus, Rotarix, reaches children across 25 Gavi-eligible countries and four former Gavi countries. We have offered vaccines to civil society organisations serving refugees and working in other emergency situations through the Humanitarian Mechanism since 2017. We are also a long-standing supplier of oral polio vaccines through UNICEF and, in 2023 alone, supplied around 130 million doses to help eradicate polio. Neglected tropical diseases In 2023, we donated 615 million albendazole tablets to help tackle lymphatic filariasis (LF), soil transmitted helminths and echinococcosis, taking the total we have donated to over 11 billion. We remain committed to supplying albendazole to endemic countries until LF is eliminated everywhere. So far, LF has been eliminated in 19 countries including Bangladesh and Lao PDR, who announced elimination of the disease in 2023 – significant milestones in our collaborative effort to get ahead of disease together. The number of tablets we are donating is declining each year, given the gradual eradication of the neglected tropical diseases (NTDs) that the medicine is targeting. 47 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued The programme has benefited over 935 million people since it began, according to WHO data. HIV In 2023, Aurobindo, Cipla and Viatris, three generic manufacturers, signed sub-licences of ViiV Healthcare’s licence with the Medicines Patent Pool (MPP) to develop, manufacture and supply generic versions of cabotegravir long-acting for HIV pre-exposure prophylaxis (cabotegravir LA for PrEP) in 90 countries, subject to obtaining regulatory approvals. ViiV Healthcare also works with global health agencies, NGOs, governments and community partners to plan for and support the introduction of ViiV-manufactured cabotegravir LA for PrEP introduction into national programmes. In late 2023, our first orders of cabotegravir LA for PrEP were delivered to a global partner for programmatic use in low- and middle-income countries. ViiV Healthcare also has voluntary licensing agreements with 15 generic manufacturers to produce and sell low-cost single or fixed-dose combination products containing our HIV medicine dolutegravir for adults. These agreements cover 95 low- and middle-income countries, with one direct licence and the others via the MPP. There are similar agreements with 14 generic manufacturers for children, covering 123 countries, as well as separate agreements to enable greater access to dolutegravir in certain upper middle-income countries. In total, around 24 million people living with HIV across 128 countries had access to a generic product containing dolutegravir by the end of 2023. This is more than 90% of people living with HIV on antiretrovirals in generic-accessible low- and middle-income countries. Malaria To date, over two million children in Ghana, Kenya and Malawi have been reached with at least one dose of Mosquirix (RTS,S/AS01E) through the WHO-coordinated Malaria Vaccine Implementation Programme. Developed by GSK and our partners, Mosquirix is a significant scientific breakthrough – it is the world’s first malaria vaccine and first vaccine against any human parasite. In July 2023, Gavi announced that up to nine more African countries are to be allocated doses of Mosquirix from early 2024. We have committed to supply a total of 18 million doses to Gavi-eligible countries between 2023 and 2025, with a plan to produce 15 million doses annually from 2026 to 2028. In 2023, a landmark study by the London School of Hygiene & Tropical Medicine showed that combining Mosquirix with antimalarial drugs in areas of Africa with seasonal malaria reduced malaria cases and deaths in young children over a period of five years. These findings confirm the potential of seasonal vaccination to provide a high level of protection over the first five years of life, when this protection is much needed. Helping to strengthen healthcare systems In 2023, GSK and ViiV Healthcare joined forces with The Global Fund to pledge $7.5 million over three years to create the Gender Equality Fund, which will support community- based and -led organisations that are working to deliver lasting changes in health policies and programmes focusing on TB, HIV and malaria for women and girls in all their diversity. The Bill & Melinda Gates Foundation has committed to match this donation. We also renewed our partnership with Save the Children for another five years. Building on learnings over the last decade, we are focusing our partnership on reducing the number of ‘zero dose’ children – those who have never received a vaccine – in Ethiopia and Nigeria, which represent more than a third of the zero-dosed children in Africa. + For full details of our progress in our six focus areas, please see our ESG Performance Report Global health and health security We want to help address the biggest health challenges faced by people around the world. Our commitment To develop novel products and technologies to treat and prevent priority diseases, including pandemic threats Our ESG Performance Rating metrics – Progress six Global Health pipeline assets to address priority WHO diseases – Progress eight active R&D projects that address pathogens prioritised by WHO and CDC as posing the highest level of concern due to drug resistance (critical and/or urgent threats) (1) Budget phasing is not linear across the 10 year period. Progress in 2023 Global health R&D In 2022, with ViiV Healthcare, we announced an investment of £1 billion over 10 years to accelerate global health R&D. By the end of 2023, we had invested 21%1 of this and progressed 11 Global Health pipeline assets to address priority WHO diseases, including climate-aggravated diseases that have a disproportionate impact on lower income countries. Promising avenues for tuberculosis prevention and treatment GSK is committed to tackling tuberculosis (TB), one of the world’s deadliest diseases. We have developed a promising candidate vaccine, M72/AS01E, up to proof of concept (phase IIb). Building on our long-standing, successful history of working with external partners we have partnered with the Bill and Melinda Gates Medical Research Institute (MRI) for its further development. 48 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Gates MRI is well positioned to lead the large and complex phase III study required. In June 2023, Wellcome and the Bill and Melinda Gates Foundation announced funding of up to $550 million for phase III trials. If these trials are successful, M72/AS01E could be the first new vaccine to help prevent pulmonary TB in over a century. Breakthroughs in malaria research and treatment In August 2023, we announced that GSK scientists had discovered a strain of a naturally occurring bacterium that could potentially help eradicate the disease. The Tres Cantos 1 (TC1) strain of the Delftia tsuruhatensis bacterium significantly reduces the load of P. falciparum malaria parasites in mosquitoes. This could potentially inhibit transmission of the parasite to humans. We continue to pursue this ground-breaking research while engaging with global health institutions and partners to identify the most effective and sustainable approach for development and mobilisation if successful. Supporting innovation through capacity and capability building Through our Africa Open Lab initiative, launched in 2014, we support early-career scientists based in sub-Saharan Africa focusing on infectious diseases that disproportionately affect sub-Saharan populations, such as malaria, TB and AMR. In 2023, we agreed grants to ten researchers in six countries in sub-Saharan Africa and announced a further call for proposals in November. We are also working with African academic institutions to provide grantees with supplemental training in areas including epidemiology, statistics and clinical research. Strengthening health security There are many factors that can jeopardise our health security – from new and emerging infectious diseases to the rise of AMR. Our primary contribution to strengthening health security is through our innovation to prevent and mitigate infectious disease. Environment Climate change and nature loss are an urgent threat to human health, as well as a risk to business resilience. To get ahead of disease and to help ensure long-term business success, we need to take action on climate and nature. Our commitment Commit to a net zero, nature positive, healthier planet with ambitious goals set for 2030 and 2045 Our ESG Performance Rating metrics1 – Operational emissions reduction (Scope 1 and 2 market- based emissions) – Industrialisation of low-carbon Ventolin initiated, and clinical and non-clinical data available to support regulatory submissions – Percentage of carbon offset volume in project pipeline We have more than 30 R&D projects across medicines and vaccines that are relevant to AMR, ranging from early- to late-stage development, with 12 R&D projects targeting pathogens deemed ‘critical’ or ‘urgent’ by the WHO and the US Centers for Disease Control and Prevention. These include gepotidacin, which could be the first novel oral antibiotic treatment for uncomplicated urinary tract infections (UTIs) in over 20 years. Positive phase III data from the EAGLE-2 and EAGLE-3 trials were presented at the European Congress of Clinical Microbiology and Infectious Diseases in Copenhagen in April 2023. In March 2023, we announced an exclusive licence agreement with Scynexis for Brexafemme (ibrexafungerp tablets), a first-in-class antifungal for the treatment of vulvovaginal candidiasis (VVC) and for reduction in the incidence of recurrent VVC. Progressing vaccines against enteric diseases to reduce the burden of antimicrobial resistance Antimicrobial resistance (AMR) is a major threat to health globally, and it is particularly prevalent in low-resource settings. We continue to progress candidate vaccines against several enteric diseases which contribute to the burden of AMR, including invasive non-typhoidal salmonella, klebsiella, shigella, typhoid and paratyphoid fever. In 2023, it was announced that we are partnering with LimmaTech Biologics for the further development of a candidate vaccine against shigellosis, while we continue to develop another candidate vaccine against the disease which uses our vaccine platform technology, GMMA. Currently, there are no vaccines to help prevent shigellosis, a disease which causes 600,000 deaths each year. See page 17 for more about our R&D pipeline. + For full details of our progress in our six focus areas, please see our ESG Performance Report – Average of the percentage of GSK sites and suppliers compliant with wastewater active pharmaceutical ingredient limits and the percentage of suppliers that are compliant with the AMR Industry Alliance Common Antibiotic Manufacturing Framework and discharge limits – Percentage of paper and palm oil deforestation free – Operational waste and material reduction at our sites (1) These metrics are related to the ESG Performance Rating outlined in our ESG Performance Report 2023. We also measure and report performance against our public environmental sustainability targets, which we publish on gsk.com 49 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Progress in 2023 Climate We have a clear pathway to a net zero impact on climate with ambitious goals for 2030 and 2045. In 2023, the Science Based Targets initiative (SBTi) approved GSK’s net zero target for 2045 in line with its Corporate Net-Zero Standard, the world’s only framework for corporate net zero target setting in line with climate science. Our value chain carbon footprint1 is made up of: – Scope 1 and 2 emissions from our own operations (7%) – Scope 3 emissions from our supply chain (31%) – Scope 3 emissions from patients using our products (57%), mostly metered-dose inhalers (MDIs) – Scope 3 emissions from logistics (4%) – Scope 3 emissions from the disposal of our products (1%) Targets2 – 80% absolute reduction in greenhouse gas emissions from a 2020 baseline, across all scopes, and investment in nature-based solutions for the remaining 20% of our footprint by 2030 – 100% imported renewable electricity by 2025 and 100% renewable electricity (imported and generated) by 2030 (Scope 2) – Net zero greenhouse gas emissions across our full value chain by 2045: 90% absolute reduction in emissions from a 2020 baseline, across all scopes, and all residual emissions neutralised Performance In 2023, we reduced our Scope 1 and 2 carbon emissions by 10% compared with 2022, and by 27% compared with our 2020 baseline. This was primarily from energy efficiency measures and increasing the amount of renewable electricity we use. As a member of the RE100 initiative, we have committed to reach 100% of our imported electricity from renewable sources by 2025 and 100% of all electricity we generate and import from renewable sources by 2030. In 2023, we reached 83% imported renewable electricity, an increase of 10% from 2022. We signed a power purchase agreement to source renewable electricity to cover 50% of our electricity demand for our sites in Europe from mid-2026. Two additional wind turbines and the new solar farm at our manufacturing facility in Irvine, Scotland began generating renewable energy. (1) Based on 2022 data (2) The target boundary includes biogenic land-related emissions and removals from bioenergy feedstocks (3) We previously reported our Nature targets grouped by water, waste and materials, and biodiversity. In 2023, we updated our target categories to align with the four areas of nature as defined by TNFD and SBTN, with underlying targets on waste and materials. The targets remain the same Our overall Scope 3 emissions are 10% lower than our baseline year of 2020, although there was a 4% increase in 2022 (our latest available data) compared to 2021. This was primarily driven by higher sales of metered dose inhaler (MDI) products. Although overall Scope 3 emissions increased from 2021 to 2022, in the same period, we reduced upstream Scope 3 emissions from our suppliers. The goods and services we buy to make our medicines and vaccines, and additional upstream emissions, account for approximately 31% of our total emissions footprint. In 2023, our supply chain emissions fell by 2%. The use of our medicines and vaccines makes up 57% of our total footprint. Most of this is from the propellant used in MDIs for asthma and chronic obstructive pulmonary disease (COPD). GSK’s rescue MDI medication, Ventolin (salbutamol) is an essential medicine prescribed to approximately 35 million people with respiratory conditions worldwide. Patient use of the inhaler, due to the current propellant, accounts for just under half (48%) of our carbon footprint. We are investing in a low-carbon programme with the potential to reduce greenhouse gas emissions from the inhaler by 90% by transitioning to a next generation, lower carbon propellant. Phase III trials will begin in 2024 and, if successful, regulatory submissions will start in 2025. This is to supplement our existing low carbon dry powder inhalers. See pages 62 to 70 for our disclosure on climate risk and resilience in line with the Task Force on Climate-related Financial Disclosures (TCFD) framework. Nature In 2023, we shared more detail on our plan for contributing to a nature-positive world, in line with the goal of the Global Biodiversity Framework to halt and reverse biodiversity loss by 2030. It sets out how we approach nature through four focus areas – freshwater, land, oceans and atmosphere – including the biodiversity of living species across these areas.3 We aim to deliver our contribution in three ways: avoiding or reducing our impact on nature, protecting and restoring nature, and helping to accelerate collaborative action. This approach is aligned with the work of the Taskforce on Nature-related Financial Disclosures (TNFD) and the Science Based Targets Network (SBTN). In May 2023 we were selected to be part of the first group of companies to participate in the initial target validation process with SBTN to set validated science-based targets for nature, starting with targets for freshwater and land, followed by targets for oceans and biodiversity. We have already started to implement the final TNFD recommendations in our 2023 disclosure, which you can read on page 70. 50 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Freshwater We continue to work towards our existing water targets. Targets – Achieve good water stewardship at 100% of our sites by 2025 – Reduce overall water use in our operations by 20% by 2030 – Be water neutral in our own operations and at key suppliers in water-stressed regions by 2030 – Zero impact API levels1 for all sites and key suppliers by 2030 Performance We achieved our overall water reduction target in 2022. In 2023, we reduced overall water use in our operations by an additional 1% compared with 2022 and by 6% in sites in high water stress regions. This is a decrease of 24% for overall water use and 11% for sites in high water stress regions against our 2020 baseline. For our sites and key suppliers located in water-stressed areas, we are developing catchment-level water replenishment, restoration and regeneration projects, including partnering with NGOs to deliver our water neutrality target. In 2023, 87% of all sites and key suppliers were compliant with AMR Alliance and API Wastewater discharge limits. This is down from 94% in 2022, primarily due to a scope expansion. This is driven by us expanding our scope to include more API suppliers which led to a decrease in the percentage of key suppliers that were confirmed to be within Wastewater API discharge limits. Our work to strengthen responsible manufacturing of antibiotics was highlighted as an example of good practice in a 2023 report on the issue from the Access to Medicine Foundation’s AMR Benchmark. Land We continue to deliver on our existing land targets. Targets – Positive impact on biodiversity at all sites2 by 2030 – 100% of agricultural and forestry-derived materials sustainably sourced and deforestation free by 2030 Performance During 2023 we completed baseline assessments for six of our sites, meaning we have now assessed all our sites, using the Natural England Biodiversity Net Positive methodology. In parallel, we have plans in place to improve biodiversity at nine of our manufacturing sites from 2022. We set out ambitious new Sustainable Sourcing Standards for suppliers who provide us with materials that are highly dependent on nature, like lactose, gelatine and soy. (1) Below the predicted no-effect level (2) GSK-owned sites We have roadmaps in place to achieve 100% sustainably sourced paper packaging and palm oil by 2025. In 2023, 86% of our paper packaging was derived from certified sources or from recycled raw materials and 98% of our core palm oil materials were certified by third-parties as being from sustainable sources. While working with suppliers is a key part of our goal to reduce our impact on nature, where appropriate we will also look at opportunities to reduce or avoid the use of some natural materials, including through process efficiencies and synthetic alternatives. For example, we are working on a process improvement to deliver a significant yield increase, reducing our nature impact and improving supply resilience. Oceans We continue to deliver on our existing ocean target (set out below), and will apply the relevant science-based methodology on oceans when it becomes available. Target – 100% of marine-derived materials sustainably sourced by 2030 Performance Our impacts and dependencies on oceans come primarily from marine-derived materials that are a critical part of manufacturing vaccines and medicines. For example, we use horseshoe crab blood, which is an important substance that is required by some regulators to be used in pharmaceutical and biomedical quality control processes to ensure the quality and safety of medicines, vaccines and devices. We continue to make progress on volume reductions, and we are advancing a pilot across five of our sites to test the use of non-animal alternatives. At the same time, we are engaging with regulators to support wider uptake of these alternatives. While we make progress on reducing volumes and moving to synthetic alternatives, we are working with our suppliers to improve sustainability. Our new Sustainable Sourcing Standards include a specific Marine Sustainable Sourcing Standard which outlines the requirements that our suppliers of marine-derived materials must adhere to. As part of this, we conducted physical site audits of key suppliers in 2023. Atmosphere Air pollution is a significant risk to human health, particularly for patients with respiratory conditions like asthma and COPD. Performance Our approach to air pollution includes reducing pollutants linked to burning of fossil fuels that will be addressed via our SBTi-aligned climate targets (set out on page 50), as well as looking more broadly at our air pollution footprint. We are members of the Alliance for Clean Air through the Clean Air Fund and the World Economic Forum. We have done an initial assessment to establish an air pollution footprint in our operations and our supply chain. We are creating reduction plans that are aligned to our pathway to net zero and which aim to have a positive impact on air quality. 51 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Waste and materials The overuse of natural resources and the generation of waste and pollution are key drivers of climate change and nature loss. Targets Our approach to product stewardship means that we consider and aim to address impacts on nature and climate at every stage of the product lifecycle, from discovery, design, sourcing and manufacturing through to product use and disposal. We have set a target to help accelerate the adoption of this approach: – 25% environmental impact reduction for our products and packaging by 2030 We have also set targets to reduce operational and supply chain waste: – Zero operational waste1, including eliminating single use plastics2 by 2030 – 10% waste reduction from supply chain by 2030 Diversity, equity and inclusion We want to be an inclusive business where all our people can thrive, which ensures diversity in our clinical trials and supports diverse communities. Our commitment Create a diverse, equitable and inclusive workplace; enhance recruitment of diverse patient populations in our clinical trials; and support diverse communities Our ESG Performance Rating metrics – 100% of phase III trials initiated in 2023 will have proactive plans in place designed to enrol appropriately diverse trial participants, consistent with disease epidemiology – Improve year-on-year spend with US-based certified diverse-owned suppliers – Update towards 2025 people aspirations through fair and equitable opportunities: – aspire to have women hold at least 45% of VP-and- above roles globally by the end of 2025 – aspire to have at least 30% ethnically diverse leaders in our roles at VP-and-above in the US by the end of 2025, and increase the percentage of Black or African American, and Hispanic or Latinx VP-and-above leaders year on year – aspire to have at least 18% ethnically diverse leaders in our roles at VP-and-above in the UK by the end of 2025, and increase the percentage of Black VP-and- above leaders year on year (1) Including a 20% reduction in routine hazardous and non-hazardous waste (2) Where regulatory obligations allow, and excluding plastics which are critical to product discovery and development and health & safety Product stewardship Our approach to product stewardship across both new and existing products is built on a scientific method for environmental footprinting called Life Cycle Assessment (LCA). Since 2022 we have completed an LCA analysis of 22 products using the LCA methodology which has enabled us to identify where we need to improve the manufacturing design, to assess potential savings from design changes and provide product-level information to key customers on specific products. 100% of GSK sites are now manufacturing PVC-free secondary and tertiary packaging. Waste In 2023, we reduced operational waste by 1% since last year, a total of 21% since 2020. We increased the amount of materials recovered by circular routes by 53%. We have maintained zero operational waste to landfill and we continue to build on our long-standing operational waste management programme to identify opportunities to find more beneficial uses for waste. + For full details of our progress in our six focus areas, please see our ESG + Performance Report Progress in 2023 Clinical trial diversity We continue to make progress in advancing clinical trial diversity. We met our objective of 100% of the phase III interventional trials initiated in 2023 having proactive diversity plans. We also are challenging ourselves to actively monitor patient recruitment in real time to ensure that we reach our diversity goals. In February 2023, we published a study of 17 years of GSK and ViiV Healthcare US clinical trial diversity data. It showed that enrolling participants to clinical trials based on real- world disease epidemiology data, rather than census data, would ensure that those trials reflect the populations affected by different diseases. By publicly sharing this research, we hope to advance the discussion around clinical trial diversity and improve how the pharmaceutical sector approaches the issue of clinical trial diversity. Supporting diversity in our supply chains By engaging with and mentoring small and diverse-owned businesses in our supply chain, we can help them identify potential areas for growth. In 2023, we increased our spend annually with US-based certified diverse-owned suppliers. This year, we expanded our successful US supplier diversity programme to the UK. Groups which benefit from this programme include women, ethnic minorities, members of the LGBTQ+ community, people with disabilities and military veterans, as well as small businesses in high- unemployment, low income communities. 52 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Ensuring diversity in our workplaces We are fundamentally committed to equal employment opportunity and non-discrimination for all employees and we want all our leadership to reflect our GSK people and our people to reflect the communities we work and hire in. At the end of 2023, women held 45% of VP-and-above roles globally, compared with 42% in 2022. Women made up 48% of all employees in 2023, and 50% of all management roles. In the UK at the end of 2023, we had 18.4% ethnically diverse leaders at VP-and-above, compared with 14.3% in 2022. We had 1.9% Black leaders at VP-and-above compared with 1.6% in 2022. In the US, at the end of 2023, we had 35.7% ethnically diverse leaders at VP-and-above, compared with 31.3% in 2022. We had 8.1% Black or African American leaders at VP-and-above compared with 8.6% in 2022. We had 6.4% Hispanic or Latinx leaders at VP-and- above compared with 6.4% in 2022. We remain committed to the application of fair and equitable pay practices to ensure equal opportunities and equal pay for equal work. Our 2023 gender pay gap for all permanent UK-based GSK employees is -0.50% (mean), compared to the national average of 13.2%. We are also publishing our second UK ethnicity pay gap comparing the average pay of our White and Ethnically Diverse employees. Our 2023 UK ethnicity pay gap for all permanent UK-based GSK employees is -0.74% (mean), compared with 0.06% in 2022. Ethical standards Our culture guides our people to behave in an ethical way, to do the right thing and Speak Up about any concerns they have. We expect everyone who works for us to live up to this, and we expect the same of our suppliers. Our commitment Promote ethical behaviour across our business by supporting our employees to do the right thing and working with suppliers that share our standards and operate in a responsible way Our ESG Performance Rating metrics – 100% of employees and complementary workers complete GSK’s 2023 mandatory training – Percentage of employees who believe they ‘can and do Speak Up if things don’t feel right’ is above the general industry benchmark1 – 80% of direct high-risk suppliers that achieve GSK’s minimum EcoVadis score or have an improvement plan in place (1) The general industry benchmark is 66% according to 2023 research by KornFerry In addition, within our 2023 UK ethnicity pay gap report we are also sharing the pay gaps comparing the average pay of our White employees with those in the ethnic groupings of Black, Mixed, Asian and Other. This is with reference to the UK government’s recently published guidance to provide a more granular view. This year, we added Disability Confidence training into our First Line Leader training, aimed at all our people managers. This training is designed to develop inclusive leaders that are able to promote disability confidence within their teams. We continue to work to make sure that our LGBTQ+ colleagues feel welcome, valued and included. We were once more recognised as a Gold employer in Stonewall’s Top Global Employers Index. We also relaunched our Mental Health Matters training. Available globally, it is designed to help our people spot the signs of poor mental health, know how to start a conversation with others, and signpost resources to support everyone’s wellbeing. Supporting diverse innovators for the future In the UK, we launched a £6 million, ten-year STEM equity programme, targeting 11–25-year-old girls and young women, black people and people from low socio-economic backgrounds. The programme includes nationwide STEM mentoring, delivered in partnership with established mentoring organisations. In its first three years, we aim to reach approximately 4,000 young people through this programme. + For full details of our progress in our six focus areas, please see our ESG Performance Report Progress in 2023 Supporting GSK people to do the right thing Our Code of Conduct (The Code) reflects our purpose to unite science, technology and talent to get ahead of disease together. It sets out the commitments we make as a company and to each other to deliver on our purpose and ambition. The Code is supported by additional global policies and standards. We also have an accompanying global mandatory learning curriculum, Living our Code, which all our people are required to complete. In 2023, 100% of our employees and 99% of complementary workers completed this training where due by year-end. We also have anti-bribery and corruption (ABAC) training for our people in certain high-risk roles or geographic regions. This helps them identify and mitigate any potential ABAC risk – especially in third-party relationships – and to recognise, report and manage conflicts of interest. In 2023, 100% of employees and 99% of complementary workers completed this training. 53 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Reporting and investigating concerns In 2023, we saw an overall decrease in the number of employees who had concerns raised against them, employees disciplined for policy violations and open cases at year end. This is reflective of several factors including external geopolitical and economic issues affecting some countries which changes the nature of concerns raised and, internally, our continued emphasis on appropriate management and closure of cases. Our commitment to human rights We are signatories to the UN Global Compact and our Human Rights Position Statement lays out our commitment to the UN Guiding Principles on Business and Human Rights. We have a cross-business Human Rights Steering Group, which reports to the GLT and Board’s Corporate Responsibility Committee, and drives progress on human rights impacts and risks across the business. In 2023, we carried out human rights training for priority suppliers, aimed at ensuring a good understanding of human rights and labour principles and aligned with international standards. We also continued our human rights training for procurement and third-party engagement leads, to better equip them to spot human rights issues when visiting suppliers. We conduct audits and site visits covering Environment, Health and Safety (EHS) and labour rights for our priority suppliers.1 Some of the top issues identified during supplier visits in 2023 related to policy, wages and compliance. All observations have action plans in place to drive improvement. We are committed to fair and equitable pay, ensuring that all employees globally receive pay that is competitive in their local markets and sufficient to support a sustainable standard of living. In 2023, the Fair Wage Network certified GSK as a Living Wage employer, after it reviewed the global gap analysis we conducted in 2022. It confirmed that all GSK workers are paid at or above the living wage in their relevant markets. We have also developed a consistent approach to how GSK will manage global fair wage analysis annually, as well as a methodology for the Fair Wage Network to use to continue to assess us. Working with third parties We expect our third parties to comply with applicable laws and regulations and to adopt, at minimum our ABAC and labour rights principles and, where relevant, to comply with our standards on quality, patient safety, health and safety, and the environment. In 2023, we performed over 7,500 assessments of our high-risk third parties across 17 risk areas. Across the organisation, we give additional support on EHS risks to our largest suppliers, including those who supply globally medically-critical products, as well as those who are critical to our R&D, and those largest by spend.2 (1) Our largest suppliers, including those who supply globally medically critical products, are critical to our R&D, and those largest by spend (2) GSK maintains a list of globally medically critical products. These are drug products approved to treat a life-threatening disease or medical condition for which there is no other adequately available alternative and of which GSK is the only provider (3) Our EHS priority suppliers are API suppliers who are, or will be, medically-, R&D-, or revenue-critical to GSK, or are high spend suppliers We visit sites, in person or virtually, to help suppliers better understand and control their EHS risks. This year, we conducted 73 physical visits across 63 priority suppliers.3 We conducted 47 supplier audits following industry standard Pharmaceutical Supply Chain Initiative guidelines. We trained more than 1,000 supplier employees on EHS, strengthened EHS contractual obligations and have worked with suppliers to help them improve their EcoVadis scores. Using data responsibly Data is an essential foundation to realising our ambitions for patients. Advances in artificial intelligence (AI) and machine learning (ML) technologies present tremendous opportunities, but the technologies must be approached correctly, responsibly and ethically. Increases in the volume of data processed through AI/ML use have resulted in a greater focus on data governance and the ethical use of personal information, over and above compliance with data privacy laws. We take our responsibility for data privacy seriously and we exercise high standards of integrity in dealing with personal information. Our Digital and Privacy Governance Board oversees our overall data ethics and privacy operating model, supported by digital and privacy legal experts and compliance professionals. We monitor and mitigate new and emerging cyber threats to protect ourselves from cyber security risks. We have additional governance boards that oversee the use of our data in the research, development, manufacture and supply of our products to ensure we follow regulations and meet ethical obligations. In 2023, we created a cross-functional AI Governance Council to oversee our AI strategy and to ensure responsible adoption of AI/ML. This is complemented by an internal policy to ensure AI/ML adoption is safe and aligned with GSK's culture by establishing AI Principles underpinned by the ethical standards set out in the GSK Code. Political engagement At GSK, we seek to contribute to public policy debate, especially in relation to life sciences and healthcare. We are committed to the highest ethical standards and legislative requirements in all of our political engagements. We do not make corporate political contributions, nor do we sponsor party political meetings anywhere around the world. + For full details of our progress in our six focus areas, please see our ESG Performance Report 54 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Responsible business continued Product governance Our commitment We commit to maintaining robust quality and safety processes, and using data and new technologies responsibly. Our ESG Performance Rating metrics – Average number of critical and major findings per inspection by FDA/MHRA/EMA regulators1 – Percentage of inspections from all regulators with no critical findings or official action indicated – Number of FDA warning letters – Total number of Class I/II external product recalls across all markets – Register and disclose all human subject research of GSK products. Specifically, register protocol summaries for studies initiated in 2023; and disclose results summaries for studies with results due in 2023 Progress in 2023 Maintaining quality across GSK We have a detailed and specific quality framework that describes how we comply with regulatory requirements and other standards across our markets. This addresses global and local regulations across manufacturing and distribution processes, and is based on principles defined by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. Our GSK quality function is responsible for managing quality and for ensuring a quality mindset is embedded throughout the organisation at all levels. It brings together an extensive global network of quality and compliance professionals within each of our business units, from site level to senior management. Our quality management depends upon comprehensive and ongoing patient safety and quality process training. The Quality Management System details the training required by GSK people, including induction, hygiene, safety and technical skills training, as well as good distribution and manufacturing practice training. Employees who carry out specific, quality-critical or sensitive activities are subject to additional training as necessary. (1) We consider any observations from the US FDA as major (2) Class I recalls are triggered by a reasonable probability that the use of or exposure to a violative product will cause serious adverse health consequences or death. Class II recalls address the use of or exposure to a violative product which may cause temporary or medically reversible adverse health consequences, or where the probability of serious adverse health consequences is remote. Class III recalls relate to the use of or exposure to a violative product which is not likely to cause adverse health consequences Inspections, recalls and audit In 2023, we had 114 regulatory inspections at our manufacturing sites and local operating companies, compared with 122 in 2022. We received zero warning letters from the United States Food and Drugs Administration (FDA) or critical findings from the Medicines Healthcare products Regulatory Agency (MHRA) and European Medicines Agency (EMA) regulators in 2023. We respond to and learn from all inspection findings, taking the necessary action to address them. Throughout 2023, we had two Class I product recalls and there were fewer Class II recalls compared with 2022.2 If necessary to protect patients, we will not hesitate to recall products voluntarily. Quality management along our supply chains In 2023, we conducted 1,081 quality audits of contract manufacturers and suppliers to verify that they comply with GSK standards. We have a comprehensive quality oversight model that is aligned to our Quality Management System. It uses a risk-based approach to assess, qualify, manage and monitor our third-party suppliers on an ongoing basis, driving continuous performance. Pharmacovigilance at all times We have a well-established and rigorous worldwide system to monitor and review the safety of our products throughout clinical development and after regulatory approval. We expect our partners to meet the same high standards of safety and governance. We conduct reviews of third-party safety systems, monitoring of contractual obligations and fostering collaboration through the lifecycle of the relationship. Tackling counterfeit medicines and vaccines Falsified products put the health of patients at risk and threaten our brand and reputation. We report all cases of confirmed counterfeit products to the WHO and to relevant regulatory authorities. We actively participate in legal proceedings against illegal actors, and support customs and local authorities with regular training. We also monitor online marketplaces and social media to request takedowns of sites illicitly selling prescription-only medicines. Clinical data transparency As part of our commitment to transparency, we have made 7,988 protocol summaries and 6,734 summaries of results available since the GSK trial register was set up in 2004. We have also listed 2,669 clinical trials for data sharing via www.vivli.org. + For full details of our progress against our six focus areas, please see our ESG Performance Report 55 GSK Annual Report 2023 Risk management and disclosure statements In this section Risk management 2023 principal risks summary Climate-related financial disclosures Nature-related financial disclosures Non-financial and sustainability information statement Employees by gender Viability statement 57 59 62 70 75 75 76 56 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Risk management We can only deliver our bold ambitions for patients if we maintain a well-embedded risk management and internal control framework overseen and evaluated by our Board. Controls and guidance to manage risk effectively Our well-embedded risk management and internal control framework gives our Board the ability to evaluate and oversee how the company manages principal and emerging risks in line with our strategy and long-term priorities. Our company-wide policy sets out the requirements, roles and responsibilities for the management and governance of risks and controls, as well as supporting guidance on the essential elements of our internal control framework. We routinely evaluate our risk management and internal control framework for improvements. Board oversight setting the 'tone from the top' The Board oversees our system of risk management and internal control and establishes our risk appetite, supported by the Audit & Risk Committee (ARC). The Corporate Responsibility Committee (CRC) and Science Committee further assess the effectiveness of risk management strategies that fall within their defined remits. Both the ARC and the Board oversee our cyber security risks. For more details on the Board and its committees’ responsibilities and remit, see page 116. Our Risk Oversight and Compliance Council (ROCC), co-chaired by our Group General Counsel and our Chief Compliance Officer, helps the ARC, CRC and Science Committee to oversee the risks, and the strategies used to address them. Also, risk management and compliance boards (RMCBs) across the Group promote the ‘tone from the top’, establish our risk culture and oversee the effectiveness of risk management activities, while also communicating information about internal controls. Management is held accountable for delivering on its objectives in line with the established risk appetite pertaining to principal risks. The Disclosure Committee has the responsibility for considering the materiality of information and determining the disclosure of this information in a timely way. An enterprise risk owner is responsible for each principal risk, overseen by a GLT member. Risk owners report risk and mitigation to ROCC and the appropriate Board committee each quarter. Significant risks or issues can also be escalated to the GLT, RMCB, or appropriate risk governance forum (e.g., Global Safety Board) throughout the year as needed. Legal & Compliance support these efforts by advising on our business strategies, activities, risks and controls. Audit & Assurance provides assessments of the adequacy and effectiveness of our framework. Considering the likelihood, impact and timescale of risks Our enterprise risk assessment methodology is the mechanism by which we assess all risk, including our principal risks. Our enterprise risk assessment methodology considers the likelihood and impact of risks, and the timescale over which a risk could occur based on the most probable scenario and considering our existing internal controls. Our impact assessments include considerations across patient safety, quality and supply; environment, health and safety; legal; people; regulatory; reputation; strategic objectives; and finance, incorporating materiality thresholds. As well as considering current and evolving risks, we evaluate emerging risks that could affect our ability to achieve our long-term priorities over the three-year horizon, in line with our viability statement. We also define risks as ‘emerging’ if we need to know more about how likely they are to materialise, or what impact they would have if they did. We further evaluate emerging risks and their impact on the company to assess whether they should be elevated to a principal risk. Our risk management and compliance boards at all levels identify emerging risks on an ongoing basis, and ROCC discusses evolving and emerging risks at each meeting. At the same time, we scan the risk horizon throughout the year to identify external trends that may be opportunities and/or emerging risks and monitor our business activities and internal environment. ROCC conducts an annual risk review to assess principal and emerging risks for the company. This review is supported by extensive analysis of external trends and insights, senior-level interviews and recommendations from risk management and compliance boards and risk owners. ROCC shares this annual review with the ARC and Board for assessment and agreement, forming the basis for the following year’s risk management focus. Our business strategy, results of operations and financial condition have not been materially affected by risks from cyber security threats, including as a result of previous cyber security incidents, but we cannot provide assurance that they will not be materially affected in the future by such risks and any future material incidents. 57 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Reporting our current risks The table starting on page 59 shows our current principal risks and respective trends, assessments and mitigation activities for the year. These are not in order of significance. For full risk definitions, potential impact, context and mitigating activities, see Principal risks and uncertainties on page 284. Other risks, not at the level of our principal risks, related to ESG, including environmental sustainability and climate change, are managed through our six focus areas, as described in our ESG Performance Report. Additional information on climate-related risk management is in our climate-related financial disclosures, on page 62. Changes to our risks for 2024 In our December 2023 annual risk review, the ARC agreed to ROCC’s recommendation of our principal risks for 2024, which remain largely unchanged. The emerging risk of data management will continue to be evaluated during the year. + Viability statement – see page 76 + ARC report – see page 133 + Internal control framework – see page 134 + Legal proceedings – see page 263 + Environment – see page 49 + Climate-related financial disclosures – see page 62 Risk management continued Our risk management and internal control framework Our risk management and internal control framework is aligned to industry standards and legal and regulatory requirements. It defines the essential elements we expect and helps us to identify, assess, manage, report and oversee risk relevant to our business activities. This framework helps to ensure our risks are proportionately managed in line with our risk appetite throughout the year in a timely and transparent manner to support our strategic objectives. For our principal risks, which include information and cyber security, we define enterprise risk plans that include a description of the risk, its context, our assessment, risk appetite, how we will treat the risk, and the actions businesses will take in line with our internal control framework to mitigate the risk. These plans enable our Board committees to assess the effectiveness of our risk management strategies. We report on our principal risks and emerging risks to ROCC and the respective Board committees every quarter, to drive more dynamic, data- driven discussions, agile risk management strategies and oversight. We report on existing control measures, implementation, emerging risks, external insights and key risk indicators with risk reporting thresholds aligned to risk appetite. We include risks and mitigations associated with relevant events around us, such as geopolitical tensions. Our Code sets out the overarching expectations for our employees and complementary workers. We aim to do the right thing with integrity and care as part of our culture. Our risk management framework complements our culture and Speak Up processes in making sure that we identify and mitigate risks effectively. We monitor our most important risks and take action to address issues. Our annual confirmation exercise with General Managers, Site Directors, senior leaders and GLT, checks that key risks are well managed, and that actions are in place to address gaps. Our principal risks include controls for responding to problems within their risk plans. We also have business continuity planning embedded in our framework and our critical processes, so we can continue business operations in the event of a crisis. 58 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 2023 principal risks summary Risk Patient safety Trend versus prior year → External Assessment and mitigation activities The external risk environment remains stable. Our pharmacovigilance function, like those across the industry, contends with a challenging legal and regulatory environment. Even with an optimised, state-of-the-art pharmacovigilance system we cannot predict all issues impacting safety and efficacy that could potentially result in regulatory action and/or litigation. This is particularly true of issues not based on robust scientific evidence of the ongoing benefit/risk assessment for our products. → GSK Our internal risk environment remains stable in 2023. We continue to focus on ensuring an optimised benefit/risk profile for all vaccines and medicines through appropriate safety expertise and oversight. We successfully completed a significant transition to a simplified third-party support model for global pharmacovigilance operational activities. Product quality → External The external risk environment is stable, yet remains high. In May 2023, regulatory agencies ended their emergency COVID-19 measures and resumed on-site inspections of our sites (both planned and unannounced) to make sure they meet product quality expectations. Increased nationalism following the pandemic has driven a broader spectrum of regulatory requirements. This continues to rapidly evolve with new pharmaceutical, chemical and environmental expectations for our products. The focus on data governance and data integrity remains. The application of AI/ML to improve manufacturing and quality is in its infancy, with uncertainty about how this will be regulated in the GxP arena. The US FDA is working with industry to understand its application and develop guidance. → GSK Our risk exposure remains stable. Our ongoing inspection readiness programme ensures preparedness for regulatory authority inspections. We continue to invest in technology to strengthen our data management controls and modernise our quality processes. We are proactive in anticipating regulatory expectations and continue to work at an industry level to refine quality standards and build new competencies to assure product quality. Legal matters ↑ External The external risk environment is increasing. The wide-ranging regulatory environment remains challenging, due to uncertainty, volatility and sometimes conflicting requirements, influencing the ability to determine exact requirements in each market. Government agencies, and notably the US, are increasingly looking to use competition law to tackle perceived issues with access to medicine, pricing and acquisitions. Governments are continuing to enforce anti-corruption laws and regulations, including a nationwide one-year campaign to fight corruption in healthcare in China. Sanctions continue to be complex in the current geopolitical environment, particularly those concerning Russia. → GSK Our risk exposure is stable due to robust internal systems, processes and monitoring to ensure proactive and timely response to changes by adapting our internal controls, which are designed to accommodate external regulatory fluctuations and changing risks. Financial controls and reporting → External The external risk environment remains challenging due to political uncertainty, proposed increases in the obligations of directors and auditors, increasing threats of cyber attacks and fraud, and increasing disclosure requirements including ESG and non-financial information. → GSK Our risk exposure remains stable due to our ongoing focus on the resilience of personnel and the testing of our internal control framework. We implement optimal risk mitigation through transformational programmes, technology, centralised processes, and risk and control assessments, and maintain effective tax and treasury strategies. We continually strengthen our control frameworks and collaborate with external bodies on setting standards. Commercial practices → External → GSK The external risk environment is stable. Governments remain focused on initiatives to drive down medicine and vaccine costs for consumers. The passing of the US Inflation Reduction Act (IRA) of 2022 introduces new Medicare inflation-based drug rebates and a drug pricing negotiation programme which could have an overall negative effect on us. Also, macroeconomic factors such as inflationary pressure contribute to a challenging environment for all stakeholders. Competitive pressure remains intense across therapy areas and market segments. Our risk exposure remains stable. We have a mature and robust control environment that has evolved to match the competitive enhancements to our commercial and digital practices, including significantly higher volumes of engagement with healthcare professionals. This has been supported by embedding an end-to-end speaker engagement system, eliminating zero-value contracts, enhanced case study training on the medical commercial interface, implementing a new tenders procedure, and implementing enhanced interactive digital media channel oversight. 59 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 2023 Principal risks summary continued Risk Trend versus prior year Assessment and mitigation activities Scientific and patient engagement ↑ External The external risk environment is changing. The diversity of engagement platforms continues to increase, while digital health technologies and generative AI advance rapidly. Also, the environment continues to be characterised by complex, dynamic disease areas and treatments with increased volume of patient-centric activities during all phases of the product lifecycle. → GSK Our risk exposure remains stable. We continue to build innovative digital capability and improve our engagement practices and internal controls to mitigate risk in the rapidly evolving environment. We use data and systems to monitor for emerging risks associated with scientific and patient engagement activities. Data ethics and privacy ↑ External ↑ GSK Research practices ↑ External Environment, health and safety (EHS) ↑ GSK → External → GSK The external risk environment continues to increase as the global landscape of data protection, privacy and cyber laws develops. Given that the current pace of technology-focused innovation is expected to continue, companies need to be mindful of relevant potential legislation and regulations. The increasing trend for data sovereignty could affect healthcare companies in their ability to drive medical innovation and operate internationally. Global regulators (such as the EU, UK, US and China) are also introducing legislation around the use of AI and ML which is closely aligned with privacy regulations. These regulations will play a key role in safeguarding privacy by ensuring responsible data usage, transparency and ethical use of data, while preventing biases and managing international data flows. Our internal risk exposure is increasing given our focus on data in an uncertain external environment. Our data ethics and privacy operating model has been transformed to make sure it is flexible enough to adapt to emerging privacy laws in the US, EU, UK, China and India, including addressing restrictions imposed by regulators in relation to international data transfer mechanisms. We have focused on simplifying of principles and processes, while allowing flexibility around the deployment of our model in different territories and business functions. The external risk environment is increasing as technology-focused innovation accelerates the discovery and development of medicines and vaccines. Advances in technology, expanded use of data and digital footprints, more sophisticated cyber security threats, the rising trend for data sovereignty and developing global landscape of quality standards, data protection, privacy and cyber laws, and new entrants to the sector continue to influence the environment. Companies should consider the relevant emerging legislation and regulations and impact on their ability to drive innovation and operate internationally. Our risk exposure is increasing as we adopt new technologies and scale our adoption of AI in the discovery and development of medicines and vaccines. We continue to adapt our internal business processes to enable innovation and to meet ethical, societal and regulatory expectations. The external risk environment remains stable. There are currently no external EHS risk factors that reduce our ability to discover and manufacture our vaccines and medicines safely. Our risk exposure remains stable. We've continued safety leadership training, embedding our Life Saving Rules, and adhering to our EHS standards. We have initiated a Contractor Safety programme that will deliver improvements to reduce the risk profile associated with using contractors across all business units and are strengthening our driver safety programmes. Information and cyber security ↑ External External risk continues to rise as digital footprints increase and threats from cyber security become more sophisticated, including threat actors having access to more sophisticated AI capabilities. Continued geopolitical conflicts have also increased cyber security risk to large corporations. ↑ GSK Our risk exposure continues to increase as we adopt new technologies and scale our adoption of AI across GSK. We remain on track to deliver our multi-year Cyber Maturity Programme (CMP) and other risk mitigation programmes including China, High Risk Jurisdiction, and processes and accountabilities for data management, to improve our controls and governance to identify, protect, detect, respond to, and recover from cyber security incidents. 60 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 2023 Principal risks summary continued Supply continuity → External → GSK The external risk environment remains stable. In 2023, there have been cyber attacks on two of our third-party logistics providers, which has tested our business continuity planning. The constraints seen on sourcing bioscience materials in 2022 has abated, however a new constraint is emerging on third-party sterile manufacturing capacity, which increases competition for contract manufacturing operations. Extreme weather events continue to present challenges across the industry for facilities worldwide. Our risk exposure remains stable, maintained through a combination of well-defined supply chain management processes, clear escalation pathways to ensure supply continuity and clear succession plans in place for critical supply chain roles. Our Supply Chain 2030 initiative and the integration of the Medicines and Vaccines supply chains into one organisation demonstrate our commitment to evolving our technology platforms and product portfolio without affecting supply continuity, which remains consistently high. 61 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures Management’s role in assessing and managing climate- related risks and opportunities GSK Leadership Team (GLT) The GLT meets regularly, giving members an opportunity to discuss strategic, financial and reputational matters. The President, Global Supply Chain, a GLT member, has management responsibility for environmental sustainability, which includes climate change. He is responsible for governance and oversight of risks and opportunities and makes sure there is an effective framework to manage the risks and opportunities across each of our business units, along with delivering on our commitments to a net zero, nature positive, healthier planet, with ambitious goals set for 2030 and 2045 across our entire value chain. In 2023 GLT reviewed and discussed the mid-year performance for key environmental metrics, including climate-related ones (see page 49) as part of reviewing GSK’s ESG Performance Rating. GSK Sustainability Council The Sustainability Council, held quarterly, is attended by senior leaders from across the business. Members include leaders from procurement, finance, HR, compliance, R&D, manufacturing and corporate affairs. The Council is co- chaired by the President Global Supply Chain and the VP Sustainability and supported by the global Sustainability team and external third parties, who provide specialist expertise and advice to the business. In 2023 the Council: – approved the annual targets for the climate Key Performance Indicators (KPI) of the sustainability programme – reviewed monthly performance and escalations of any potential concerns or issues – approved the annual climate risk review and approach for risk disclosure – agreed that the newly formed ESG Reporting Hub would be accountable for assurance of environmental data in 2023 – reviewed progress of the core programmes to improve the sustainability of our supply chain – reviewed progress towards securing a portfolio of carbon credits in support of our 2030 commitment Our climate-related financial disclosures are consistent with the recommendations and recommended disclosures of the Task Force on Climate-related Financial Disclosures (TCFD) including the TCFD all-sector guidance, and in compliance with the requirements of LR 9.8.6R.(8) (UK Listing Rules). The disclosures are in compliance with the Companies (Strategic Report) (Climate-related Financial Disclosure) Regulations 2022 of the Company Act 2006. In 2023 we have updated our risk assessments to reflect changes in the supply chain and the progression of our sustainability transformation programme. Governance The board’s oversight of climate-related risks and opportunities Board The Board considers climate-related matters throughout the year. This includes assessing risk management processes, challenging and endorsing the business plan and budgets, including overseeing major capital expenditures, acquisitions and divestments. In 2023, the Board approved progression to the next phase of development of the low carbon Ventolin programme. The Corporate Responsibility Committee (CRC) exercises oversight, provides guidance and reviews our ESG performance, including climate-related risks and opportunities, and environmental performance against targets. The CRC receives quarterly updates on environmental sustainability, including climate. Regular attendees include the CEO, and the President Global Supply Chain. See page 116 for further details of the Board architecture. In 2020 the CRC reviewed and approved GSK’s twin goals on climate and nature. Following the demerger of the consumer healthcare business in July 2022, the CRC approved that GSK would submit updated refreshed targets to the Science Based Targets initiative (SBTi) that are aligned to a 1.5°C pathway, and to align to the SBTi Net Zero Standard, to reduce carbon emissions by 80% by 2030 and 90% by 2045. In 2023 the CRC met five times and discussed climate- related issues on three separate occasions with management. It focused on: – progress in delivering against our climate ambitions including low carbon Ventolin and Nature Plan updates – implications of the geopolitical landscape – key milestones and decisions required to achieve net zero targets – mid-year performance for key environmental metrics, including climate-related metrics, as part of reviewing the interim ESG Performance Rating for 2023 – approved our climate disclosure statement and final ESG Performance Rating for 2022 and other public environmental reporting and disclosures 62 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Other business support The Sustainability Council is supported in assessing and managing climate-related risks and opportunities by: – the sustainability programme steering team, which is chaired by the VP Sustainability that meets monthly and co-ordinates the sustainability programme and associated workstreams. This team monitors programme performance and the progress of the enablers required to deliver the sustainability programme – sustainability councils within each business, which meet quarterly to review their business unit performance and delivery against the company sustainability ambition. These are chaired by senior leaders within the business who also attend the GSK sustainability council – the Metered Dose Inhaler steering team, which is attended by senior leaders from across the commercial, supply chain, regulatory and R&D businesses aligned to our respiratory business. This team is chaired by the President Global Supply Chain, who also chairs the Sustainability Council and is the decision-making body for the programme to reduce the climate impact of metered dose inhalers which contribute to approximately 50% of GSK’s total GHG emissions – the Capital Allocations Board (CAB), which is chaired by the CFO and includes the Group Financial Controller, reviews climate-related capital expenditure as part of its annual planning and capital allocation process – the ESG Reporting Hub, which was established in 2023, provides oversight and assurance of ESG performance data, including carbon emissions data – The carbon offset programme steering committee, which includes the Group Financial Controller and the VP Sustainability, who also attends Sustainability Council, reviews the due diligence outcomes of potential carbon offset projects, the performance of established investments and makes new investment decisions – A cross-functional team from the Sustainability, Finance, Supply Chain and Procurement functions performs an annual review of climate risks to monitor previously identified climate risk and escalate new or emerging climate risks to the Sustainability Council – Results of climate scenario modelling are shared with business unit Risk Management Control Boards (RMCB) Strategy The climate-related risks and opportunities we have identified over the short, medium, and long term Climate-related risks and opportunities are considered in three different time horizons: 1. short term (less than three years) aligning with financial planning timeframes 2. medium term (three to ten years) aligning with long-term business forecasting timeframes 3. long term (more than ten years) to enable us to explore the uncertainties in changes to weather, disease patterns and societal responses to climate change across the globe We have identified and prioritised these climate-related risks and opportunities: Risks: – changes to regulations governing the supply of high global warming potential (GWP) substances by the EU, UK and US governments could restrict our ability to manufacture metered dose inhalers – future regulatory policy responses to address climate change could lead to the imposition of carbon taxes by countries where we manufacture and source goods from third parties – increasing levels of water stress could lead to interruptions to supply of water to our and third-party supply sites – increasing frequency and impact of extreme weather events that could disrupt to GSK and third-party supplier sites – nature-based projects might not deliver sufficient volumes of carbon credits to offset 2 million tonnes CO2e per year from 2030, requiring us to buy additional credits at higher cost Opportunities: – At COP28 in 2023, more than 70 countries committed to provide low-carbon healthcare systems. This could lead to increasing demand for low-carbon medicines and vaccines – Several reports exploring the impact of climate change and health have shown that climate change affects water- and vector-borne diseases. This could lead to increasing demand for new medicines and vaccines The processes for identifying and assessing climate-related risks and opportunities are set out in the Risk Management section. We will continue to monitor for emerging risks and new data to include in future assessments. The impact of climate-related risks and opportunities on our business, strategy and financial planning Our commitment to work towards a net zero, nature positive, healthier planet with ambitious goals set for 2030 and 2045 is embedded in our strategic long-term priorities, always considering the social, environmental and governance impacts of everything we do from laboratory to patient. Our near-term carbon reduction target is an 80% reduction in Scope 1 & 2 and Scope 3 carbon emissions by 2030. Our long-term carbon reduction target is a 90% reduction in Scope 1 & 2 and Scope 3 carbon emissions by 2045. Both targets are measured against a 2020 baseline. These targets are aligned to the 1.5°C pathway and were approved by the Science Based Targets initiative (SBTi) during 2023. 63 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Transition plan We are taking action to reduce emissions across our full value chain, prioritising the highest-impact areas. We will invest around £1 billion from 2020-30 to deliver emissions reductions and removals to achieve our targets though the activities outlined below. Beyond 2030 we expect we will be left with the harder- to-tackle emissions from across our supply chain, our own operations, logistics, and disposal. In many cases, addressing these residual emissions is likely to depend on technologies, infrastructure and regulatory frameworks that require broad public/private collaboration. So our decarbonisation plan is interdependent with the broader economic transition and follows a similar timeframe. Our progress in reducing carbon emissions can be found on page 50. Direct operations In order to continue reducing Scope 1 & 2 emissions across our operations by 2030, we are focusing on: – maximising energy efficiency in our sites through our long-standing energy efficiency programme – transitioning to 100% imported renewable electricity by 2025 by investing in power purchase agreements, supplemented by the purchase of energy attribute certificates – increasing the use of electric vehicles by our sales fleet Risks and uncertainties In some markets where we operate, such as Singapore, accessing renewable electricity will be challenging because of the limited generation capacity and the market boundary rules governing imported electricity. There are uncertainties in the transition to renewable heat. High-temperature heat produced by electricity is not generally commercially available today. Biogas can replace natural gas without introducing major changes to facilities but is not widely available in the locations where we operate. The use of biomass as fuel could introduce issues of land use change and impacts on local air quality. The transition to 100% electric vehicles by 2030 could be restricted by vehicle availability, lack of charging infrastructure and sourcing of key materials for battery production. Supply chain Our Sustainable Procurement Programme requires our suppliers to disclose emissions and set carbon reduction targets aligned with a 1.5°C reduction pathway. We also work with suppliers, particularly those with the largest footprint, to encourage them to adopt new sustainability measures. Supply chain emissions are a shared challenge across our sector, and we are working with our peers on collaborative initiatives such as: – the Activate programme to help Active Pharmaceutical Ingredients (API) suppliers accelerate decarbonisation initiatives – the Energize programme to encourage the use of renewable energy throughout the pharmaceutical sector’s supply chain – the Manufacture 2030 initiative to encourage suppliers to measure, manage and reduce their emissions – the Pharma LCA consortium is a group of eight global pharmaceutical that have come together via the Pharmaceutical Environment Group with support from the Sustainable Markets Initiative to co-develop a shared way of measuring and reporting environmental product footprints Risks and uncertainties Pharmaceutical manufacturing processes are highly regulated by different agencies across the world which may slow down the implementation of some decarbonisation initiatives. Our supply chains are complex and can involve several intermediate stages of production that are highly product- specific. Our volume demand on specific materials is quite low which can reduce our ability to influence where we only purchase a small share of a supplier's production. Many suppliers are based in regions where renewable electricity and heat is less available than elsewhere. Measuring Scope 3 emissions is complex and challenging and there is a lack of primary data from suppliers. Methodologies involve using spend-based estimates mixed in with activity-based data, industry average data and extrapolations based on subjective choices and judgments. As data systems, processes and controls mature and more primary data becomes available, there may be the need to restate reported emissions data in the future. Product impact The use of our products makes up 57% of our carbon footprint. Patient use of GSK’s rescue metered dose inhaler (MDI) medication, Ventolin (salbutamol), accounts for just under half (48%) of our carbon footprint. We are investing in an R&D programme and a large factory upgrade project to redevelop this inhaler by transitioning to a lower-carbon propellant. Recent data from early clinical trials has supported the decision to progress to phase III and dosing of first patients is planned in the first half of 2024. If successful, regulatory submissions will begin in 2025. Risks and uncertainties Metered dose inhalers are complex devices, and any new medical propellant must meet a specific range of technical performance characteristics to be safe and efficacious for patients. We are engaging with medical regulators such as the US Food and Drug Administration (FDA), European Medicines Agency (EMA) and the UK Medicines and Healthcare Products Regulatory Agency (MHRA) on how advances in pharmaceutical product design can reduce the environmental impact of medicines. 64 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Carbon credits While we are focused on emissions reductions to meet our carbon targets, we are also investing in high quality nature protection and restoration projects that support our net- zero and nature positive goals and deliver co-benefits to human health to generate carbon credits to offset annually the 20% of our baseline value chain carbon footprint from 2030. The volume of credits required will taper down to 10% as we continue to reduce our emissions, aiming to achieve net zero emissions across our full value chain by 2045. Our criteria for high quality projects include avoidance of harm, transparency, additionality, permanence, mitigation of leakage, project monitoring, reporting and verification of claims and avoidance of double counting. For our 2030 target we are prioritising carbon removal credits, but we will also secure a proportion of carbon avoidance and reductions credits in recognition of their critical role in conserving existing carbon stocks and protecting nature. For our 2045 Net Zero target, we will aim to secure only carbon removal credits. Risks and uncertainties We recognise that this is a fast-moving field, and that methodologies and guidelines will likely evolve as we implement our plans. We commit to remaining flexible and transparent about our progress and learning. There is a risk that the nature-based projects do not deliver sufficient volumes of carbon credits to meet our needs in a given year and that we may need to purchase of more credits at higher cost. Climate scenarios We use climate scenarios to inform management about climate risks, reporting the results to Risk Management Control Boards (RMCB) in the business as well as to the Sustainability Council. We have developed modelling tools with the support of third parties that enable us to model the impacts of physical and transition risks where our sites and supply chains are located. For example we have modelled the probability of an interruption from an extreme weather event at our key sites and supplier sites and the subsequent financial impact of that interruption assuming the inventory levels carried under existing business continuity plans. We have modelled the impact of future carbon taxes, such as direct taxes on energy-related emissions, emissions trading schemes and taxes from carbon border adjustment mechanisms assuming we deliver our carbon reduction glidepath to 2030 and beyond. In 2022, we reviewed and updated our climate scenarios first developed in 2019. We intend to review the scenarios again in 2025 to make sure they'll remain up to date.. (1) IEA Net Zero emissions scenario, https://www.iea.org/reports/global- energy-and-climate-model/net-zero-emissions-by-2050-scenario-nze last accessed 17 November 2022 (2) IEA World Energy Outlook 2021, Chapter 2, p94, download report from https://www.iea.org/reports/world-energy-outlook-2021/overview, last accessed 17 November 2022 (3) IEA Announced Pledges, https://www.iea.org/reports/global-energy- and-climate-model/announced-pledges-scenario-aps last accessed 17 November 2022 Net zero scenario (SSP 1 – RCP 1.9) This scenario sets out a narrow but achievable pathway for the global energy sector to achieve net zero CO2 emissions by 20501. It does not rely on emissions reduction from outside the energy sector to achieve its goal. The scenario is consistent with limiting the global temperature rise to 1.5°C without a temperature overshoot. Net zero means huge declines in the use of coal, oil and gas and a shift to renewable energy sources. Low-carbon scenario (SSP 1 – RCP 2.6) In this scenario, all current net zero pledges are achieved in full and there are extensive efforts to realise near-term emissions reductions; advanced economies reach net zero emissions by 2050, China around 2060, and all other countries by 2070 at the latest2. The scenario is consistent with limiting the global temperature rise to below 2°C. With some level of net negative emissions after 2070, the temperature rise could be reduced to 1.5°C in 2100. Current trajectory scenario (SSP2 – RCP4.5) This scenario sets out to show to what extent announced ambitions and targets are on the path to deliver the emissions reductions required to achieve net zero emissions by 20503. The temperature rise will exceed 2°C by 2100, with a more noticeable shift to happen in the latter half of the century. A net zero pledge for emissions within the scenario does not necessarily mean that CO2 emissions from the energy sector need to reach net zero, but there is an allocation for carbon offsetting within the pledges. Breach of planetary boundaries scenarios (SSP 5 – RCP 8.5) This scenario is not aligned to any of the pledges laid out in the Paris Agreement and is one where countries are unable to meet the United Nations Sustainable Development Goals. This scenario will have the most severe physical consequences for the planet. The temperature rise will exceed 4°C by 2100, leading to high loss of biodiversity and species extinction. Risk management Our processes for identifying and assessing climate-related risks The nature of the risks and opportunities from climate change depends not only on the physical aspects of climate change, but also regulatory and commercial changes in the markets in which we operate, including pressures to reduce the climate impact of our metered dose inhaler medicines. Our risk management policies are designed to address all types of risks, including the Group principal risks and uncertainties. Climate risk management follows the same policy and framework. Risks from climate change at Group level fall under the governance of the CRC with the support of the Sustainability Council. Individual risks from climate change are raised with appropriate business unit or functional Risk Management Control Boards to make sure we integrate these risks into business risk management processes. 65 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued A specific and dedicated environmental sustainability risk management plan was put in place in 2020. The risk management plan covers expectations that we are addressing our impact on the environment, and that the environment has increasing impacts on operational resilience, such as access to energy, water and the natural resources used in products, along with any anticipated cost increases from regulatory changes or environmental taxes. We review developments in policy and regulations at global and national level, receiving quarterly monitoring reports. We have procedures to identify risks from climate change when factors evolve, for example to assess the climate impact of merger and acquisition activity, or the construction of new buildings. We use a shadow carbon price of $100 per tonne CO2e to inform decision-making on investments in major capital expenditure to understand the implications on potential carbon offset costs for the carbon emissions from our value chain in 2030. This value is based on the recommendation by the Carbon Pricing Leadership Coalition that concluded in 2017 that the explicit carbon price level required to drive change to restrict temperature increases to below 1.5°C is at least US$50–100/tCO2 by 20301. We monitor the value used for internal carbon pricing against estimates for the future costs of carbon credits. Our processes for managing climate-related risk For the purposes of this disclosure, we differentiate between 'physical' and 'transition' climate-related risks. Physical risks are typically identified at the asset or project level and are managed depending on the level of risk assessed. We use climate scenario analysis to model the potential impacts of our prioritised physical risks which helps us understand the resilience of our supply chains against climate change. Transition risks are typically risks associated with changes to regulations or societal expectations during the transition to a lower-carbon economy. They are identified at enterprise level and at market level. We manage transition risks through our investment decisions, our sustainability transformation programme and our procedures. For example, we manage risks which may arise from product claims based on environmental performance by using external accreditation processes and organisations to review the evidence used to support these claims. Our Communications and Government Affairs team manages corporate reputation by identifying and monitoring of climate-related issues and undertaking both proactive and reactive engagement with relevant stakeholder groups to communicate our position. Details of how we manage our prioritised risks are in the Risk Table. How our processes for identifying, assessing and managing climate related risks are integrated into overall risk management On an annual basis, a cross-functional team from Sustainability, Finance, Supply Chain and Procurement functions reviews climate risks. Climate-related risks are considered from a strategic and operational perspective to make sure we maintain a comprehensive view of the different types of climate risks we face and the different time horizons in which they may affect us. The team review previously identified climate risks, plus new or emerging risks and opportunities, and make recommendations in a paper to the Sustainability Council. Risk assessment papers are prepared for the prioritised risks, considering the likelihood and financial impact on us of each risk under different climate scenarios. Each risk and opportunity is analysed to understand how we are managing them, the metrics and targets being used and the potential impact on our total profit using a low (<£100 million), medium (£100 million – £250 million) or high (£250 million) threshold. The impact assessments are approved by the VP Sustainability and a Finance VP from our Global Supply Chain business unit. The results are shared with Business Unit Risk Management and Compliance Boards (RMCB) and the Finance RMCB to make sure risks are both contextualised with other business risks and managed appropriately. This allows management to take a holistic view and optimise risk mitigation responses, to ensure that responses to climate-related risks are properly integrated into the relevant business unit and function activities. The resilience of our strategy, considering different climate- related scenarios, including a 2°C or lower scenario We used the climate scenarios described above to stress test the resilience of the organisation by considering the impacts of potential physical and transition risks and opportunities on the locations where we operate as described in the table below. The modelling did not identify any material impact to our business resilience. (1) Report of the High-Level Commission on Carbon Prices, Carbon Pricing Leadership Coalition, 2017, p10, https:// www.carbonpricingleadership.org/report-of-the-highlevel-commission- on-carbon-prices/ 66 Metrics Targets Sites that have achieved water stewardship Total supplied water Achieve good water stewardship at 100% of our sites by 2025 Reduce overall water use in our operations by 20% by 2030 Be water neutral in our own operations and at key suppliers in water- stressed regions by 2030 Where climate- related risks to business continuity are identified, we have taken action to mitigate the risk Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Physical risk/ description GSK response The risk from increasing levels of water stress leading to interruptions to supply of water to our sites and third-party supply sites. We and our third-party suppliers use freshwater as the main source of water to manufacture medicines and vaccines. If water availability was restricted at a factory, operations would be interrupted. We have identified three water basins in water- stressed areas in Algeria, India and Pakistan where we have manufacturing sites, and where we aim to be water neutral. At our manufacturing facility in Nashik, India we have built plants for rainwater harvesting. The climate scenario analysis has identified a number of sites and supplier sites located in water basins that could become water stressed by 2050, which have been added to a watch list. We will monitor changes to the risk levels and update our site water risk assessments appropriately. The financial impact assumes we manage inventory in our supply chain to the same levels as in 2023, and water stress could lead to a three-month supply interruption as a worst case. Scenario Current trajectory Potential financial impact/ timeframe Medium (£100M- £250M)/ long term (> 10 years) Breach of planetary boundaries Medium (£100M- £250M)/ long term (> 10 years) Increasing frequency of extreme weather events causing disruption to our and third-party supplier sites. Extreme weather events from any one of precipitation (rainfall), flood from precipitation, riverine flood, extreme wind, wildfire, and extreme heat can result in short- term interruptions to manufacturing at our or supplier sites. The climate scenario modelling indicated that, of the seven physical perils, flood from rainfall presents the highest likelihood of an acute interruption. However, the risk of flooding from rainfall and from the other extreme weather events is expected to remain very low. We have performed risk assessments for our manufacturing and other operations and have business continuity plans which we review annually to respond to the impacts of extreme weather events, including adopting appropriate mitigation plans. We have a well-established loss prevention and risk engineering programme to identify a range of risks that could impact our sites and, where flood risks exist, we have taken action to mitigate them. The financial impact assumes we manage inventory in our supply chain to the same levels as in 2023, and an extreme weather event could lead to a three-month supply interruption as a worst case. Current trajectory scenario Medium (£100M- £250M)/ long term (> 10 years) Business continuity plans are reviewed annually Breach of planetary boundaries scenario Medium (£100M- £250M)/ long term (> 10 years) Transitional risk/ description Regulations governing the use of high GWP substances are being updated in the EU and UK and were updated recently in the US. This could lead to increasing costs and restrict the ability to manufacture our metered dose inhaler (MDI) products that use a high GWP propellant (HFA134a). GSK response Scenario Potential financial impact/ timeframe Metrics Targets Current trajectory scenario High (> £250M)/ medium term (3-10 years) On/off track against delivery of key milestones on the R&D programme plan We are investing in a R&D programme and a large manufacturing site upgrade project to redevelop our Ventolin (salbutamol) inhaler by transitioning to a lower-carbon propellant that could potentially reduce its carbon emissions by up to 90%, if the clinical trials are successful. We already have a portfolio of Dry Powder Inhaler products that do not use propellants that are not affected by this risk. The financial impact assumes the reformulated product is approved by regulators and launched according to plan. 80% and 90% absolute reduction in greenhouse gas emissions from a 2020 baseline across all scopes by 2030 and 2045, respectively 67 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Transitional risk/ description GSK response Future regulatory policy responses to address climate change could lead to the imposition of carbon taxes by countries where we manufacture and source goods from third parties. We are managing this risk by reducing our value chain carbon emissions in line with our transition plan described above. The financial impact assumes we deliver an 80% reduction in carbon emissions by 2030 and assumes carbon tax values are as per IEA scenarios, supplemented by data from policy pledges for a small number of countries. Nature-based projects fail to deliver the anticipated volumes of carbon credits from lower-than-expected growth or the result of a natural catastrophe. This could lead to buying more carbon credits at higher cost to make up the shortfall. We established a governance framework to manage each project with our external partners. Any issues are escalated to the carbon offset programme steering committee. We assume a future cost of £70 per tonne CO2e by 2030. For the lower-than-anticipated growth scenario we assume a 25% under-delivery in a single year as the issues will have been identified early enough to take other preventative actions. For a natural catastrophe scenario, we assume 25% of the projects will be affected and the impact will last five years. Opportunities GSK response At COP28 in November 2023, more than 70 countries committed to provide low-carbon healthcare systems. This could lead to increasing demand for low-carbon medicines and vaccines. We are reducing our own Scope 1 & 2 carbon emissions, which in turn reduces the Scope 3 footprint of our customers and suppliers. We have an Eco-design programme to reduce the impacts of all our products and packaging. We are investing in an R&D programme to reduce greenhouse gas emissions from metered dose inhalers used to treat asthma and COPD and have made good progress towards reformulating an alternative gas that could potentially reduce the climate impact by up to 90% if the clinical trials are successful. We have a portfolio of dry powder inhaler products that have low carbon footprints. We are part of a consortium of eight global pharmaceutical companies to co-develop a shared way of measuring and reporting environmental product footprints. Financial impact is based on research performed for us in 2022 on the details of published commitments to transition to low-carbon healthcare in major markets. Selected Scenario Net zero Potential financial impact/ timeframe Medium (£100M-£250M) /medium (3-10 years) and long term (> 10 years) Low-carbon Medium Metrics Targets Scope 1 & 2 carbon emissions Scope 3 carbon emissions (£100M-£250M) /medium term (3-10 year) falling to low (< £100M)/long term (> 10 years) Low (< £100M)/ in the medium term (3-10 years) and long term (> 10 years) Low (<£100M) / medium term (3-10 years) In development Medium (£100M -£250M)/ medium term (3-10 years) 80% and 90% absolute reduction in greenhouse gas emissions from a 2020 baseline across all scopes by 2030 and 2045, respectively 80% and 90% absolute reduction in greenhouse gas emissions from a 2020 baseline across all scopes by 2030 and 2045, respectively Potential profit impact/ timeframe Metrics Targets Current trajectory Lower-than- anticipated growth scenario Natural catastrophe scenario Scenario Net zero Low carbon Low (< £100M)/ Long term (> 10 years) Current trajectory Scope 1 & 2 and 3 carbon emissions Total waste and materials 80% and 90% absolute reduction in greenhouse gas emissions from a 2020 baseline across all scopes by 2030 and 2045, respectively. Zero operational waste 68 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Metrics and targets The metrics we use to assess climate-related risks and opportunities in line with our strategy and risk management process. a. Disclose the metrics used by the organisation to assess climate risks and opportunities in line with its strategy and risk management process We have considered the key metrics following the TCFD guidance of Tables A1.1 and A1.2 as well as the metrics consistent with cross-industry, climate-related metrics. Based on that, our strategic metrics are: – Scope 1 & 2 emissions (market-based and location-based approach), described in the table below – Scope 3 emissions, described in the table below – % renewably sourced electricity, described in the table below – Total supplied water, described in the table below – Total waste and materials, described in the table below – ESG composite metric, as part of our senior leaders‘ remuneration policy – see page 149 – Sites that have achieved water stewardship, described in the table below Our ESG Performance Report includes more metrics used to support the strategic metrics listed above. b. Disclose Scope 1, 2 and if applicable Scope 3 GHG emissions and related risks In energy and carbon emissions, see table below: – Scope 1 emissions from energy – Scope 1 emissions from other sources – Scope 2 emissions (market-based) – Scope 2 emissions (location-based) – Scope 3 emissions metrics – Scope 1 & 2 emissions intensity metrics c. Describe the targets used by the organisation to manage climate- related risks and opportunities and performance against targets Prioritised physical and transition risks are included in the Risk Table above. Our targets (measured against a 2020 baseline where applicable) are: – 80% absolute reduction in greenhouse gas emissions from a 2020 baseline, across all scopes, and investment in nature-based solutions for the remaining 20% of our footprint by 2030 – Net zero greenhouse gas emissions across our full value chain by 2045: 90% absolute reduction in emissions from a 2020 baseline, across all scopes, and all residual emissions neutralised – 100% renewable electricity by 2025 (Scope 2) – Achieve good water stewardship at 100% of our sites by 2025 – Reduce overall water use in our operations by 20% in 2030 – Zero operational waste1, including eliminating single use plastics2 by 2030 – Be water neutral in our own operations and at key suppliers in water-stressed regions by 2030 The performance against our targets is on page 50.3 (1) Including a 20% reduction in routine hazardous and non-hazardous waste (2) Where regulatory obligations allow, and excluding plastics which are critical to product discovery and development and health & safety (3) See Basis of Reporting 2023 in the ESG resources section of GSK.com (https://www.gsk.com/en-gb/responsibility/esg-resources/) for detailed methodologies for measuring and reporting all GSK environmental KPIs We commit to a net zero, nature positive, healthier planet, with ambitious goals set for 2030 and 2045 across our entire value chain. We report progress in reducing Scope 1 & 2 carbon emissions, Scope 3 carbon emissions, energy use, water, waste annually towards these targets on page 50, in our ESG Performance Report and in our public responses to the CDP Climate, Water and Forest questionnaires. 69 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Climate-related financial disclosures continued Metrics data Carbon emissions1,2 Carbon emissions ‘000 tonnes CO2e Scope 1 emissions (from energy) Scope 1 emissions (other3) Scope 2 emissions (market-based) Scope 2 emissions (location-based) Scope 3 emissions4 UK Scope 1 & 2 emissions Other metrics Scope 1 and 2 emissions from energy/sales revenue (tonnes CO2e/£m) Scope 1 and 2 emissions from energy/FTE (tonnes CO2e/FTE) Total energy used (GWh) UK energy used (GWh) % renewably sourced electricity Total supplied water million m3 Total supplied water in areas of high water stress million m3 Total waste and materials ‘000 metric tonne5 % sites that have achieved water stewardship 2023 301 279 64 240 – 102 2023 12.0 5.2 2,636 711 83% 7.4 0.3 49.7 100% 2022 320 306 88 265 8,995 111 2022 13.9 5.9 2,759 735 73% 7.5 0.3 50.2 100% 2021 333 300 131 285 8,624 126 2021 18.8 6.5 2,871 807 63% 7.9 0.3 55. 100% (1) All data reported excludes our previous Consumer Healthcare business unless otherwise specified (2) Carbon emissions are calculated according to the Greenhouse Gas Protocol: A Corporate Accounting and Reporting Standard (revised edition). We use market-based Scope 2 emissions for reporting purposes and report Scope 3 emissions across all 15 categories in our ESG Performance Report. We ask external assurance providers, Deloitte, to provide limited assurance to ISAE 3000 for energy, Scope 1, 2 and selected Scope 3 carbon emission data, water and wastewater data. Methodologies for reporting and measurements are provided in the Basis of Reporting 2023 in the ESG resources section of gsk.com (https://www.gsk.com/en-gb/responsibility/esg-resources/) (3) ‘Other’ refers to emissions from sales force vehicles, propellant emissions released during manufacture of inhalers (the majority of propellant emissions, released during patient use, are included in Scope 3 carbon emissions), on-site waste, or wastewater treatment and refrigerant gas losses (4) We collect and publish Scope 3 data across 15 categories. The most recent Scope 3 data available is for 2022 as the process of compiling the 2023 data is not yet complete, except for 2023 Scope 3 emissions from patient use of inhalers, which are disclosed in the ESG Performance Report. We will publish this data once it becomes available and it will be included in the 2024 ESG Performance Report (5) Data for 2021 and 2022 have been restated. See our ESG Performance Report Nature-related financial disclosures At GSK we are committed to playing our part to minimise our impact and dependencies on nature, as well as helping to protect and restore nature. Governance The board’s oversight of nature-related dependencies, impacts, risks and opportunities Human health relies on the fundamentals of nature: clean air and fresh water. Nature loss has a range of negative impacts on health, for example, reduced air quality increases the incidence and severity of respiratory diseases and habitat degradation and deforestation are increasing the risk of new human pathogens and pandemics. To protect human health and get ahead of disease, we need to protect nature. GSK is an active member of the working groups of the Taskforce on Nature-related Financial Disclosures (TNFD). We have committed to make a full disclosure against the TNFD framework in early 2026 based on 2025 data. However, we are making an initial disclosure that is not fully compliant to the framework to show the progress of our nature programme. As described on page 62. Management’s role in assessing and managing nature- related dependencies, impacts, risks and opportunities In addition to the disclosure on page 63, the Sustainability Council reviewed GSK’s Nature Strategy, ensuring alignment with ways of working required for Science Based Targets for Nature (SBTN) and that longer term budgetary requirements had been considered. Our human rights policies, engagement activities and oversight with respect to indigenous peoples, local communities, affected and other stakeholders Our position on human rights is published on GSK.com. We have a responsibility to respect human rights through our engagements with patients, our employees, our suppliers and the communities in which we live and operate. 70 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Nature-related financial disclosures continued We are at the beginning of our nature journey, and we are working to further formalise policies and procedures related to stakeholders’ engagement and human rights specifically in relation to our assessment of impacts and our action on nature. – Protecting and restoring nature is a key part of our climate and nature strategy. As nature investments are always context dependant, it is key for us to work with expert partners and NGOs to ensure project implementation includes local experts and local communities – Before we make decisions on protection and restoration projects, we run a human rights assessment as part of our broader due diligence. The assessment allows us to understand the local context and history, the process that partners use or plan to use to engage and involve local communities (including Free, Prior and Informed Consent (FPIC) and grievance mechanisms) and the how benefits will be shared – The connection between nature projects and health benefits has not been consistently included in nature projects and we have worked with third-party experts to develop and publish a toolkit to enable project developers and investors to do that Strategy The nature-related dependencies, impacts, risks and opportunities we have identified over the short, medium and long term Impacts and dependencies Water Water is essential for the production of our vaccines and medicines. We have mapped our water footprint and calculated the volume of water we use in our value chain and in our own operations and have improved our understanding as to where in the world we have the biggest impact on water. Our primary operational impact on water availability is through our own manufacturing sites that are located in areas of water stress. Using water risk data from the World Resources Institute and the World Wildlife Fund, we have identified five sites located in water-stressed areas across Algeria, India and Pakistan, which face increasing water availability and quality risks. Releases of Active Pharmaceutical Ingredients are a priority focus for us regarding water quality.1 Pharmaceutical residues may sometimes pass into the environment as part of the normal biological process following patient use. To a lesser extent, pharmaceuticals can also enter the environment from unused medical products or factory discharges. (1) For more information see our public policy: https://www.gsk.com/ media/8867/gsk-position-on-pharmaceuticals-in-the-environment- march-2022.pdf (2) Read more about our position on antimicrobial resistance in our public policy There are concerns that long-term exposure to pharmaceuticals in the environment can pose a risk to environmental species, including aquatic life. The presence of antibiotics in the environment, and its potential impact on driving antibiotic resistance as well as reducing microbial biodiversity, is a growing concern for many stakeholders and an active area of research. While clinical and agricultural practices are generally recognised as the dominant sources of antibiotics entering the environment, unregulated manufacturing practices may also contribute to anti-microbial resistance2. Land Our primary dependency on land is due to the natural materials we source, some of which derive from agricultural commodities, a key driver of deforestation and land use change, globally. The supply chains for some of these commodities are often long and complex and may be many tiers removed from our direct engagement. Our operational land holdings are relatively small, although two of our R&D sites, one in Belgium and one in Spain, are located in Key Biodiversity Areas. Oceans Our impacts and dependencies on oceans come primarily from marine-derived materials that are a critical part of manufacturing vaccines and medicines. This includes, for example, horseshoe crab blood which is an important substance that is required by some regulators to be used in pharmaceutical and biomedical quality control processes to ensure the quality and safety of medicines, vaccines and devices. Atmosphere As a leader in medicines and vaccines for respiratory health, we want to play our part in improving air quality. We have done an initial assessment to establish an air pollution footprint in our operations and our supply chain. This showed that, directly, we are having a relatively low impact on air quality, and that the largest proportion of our emissions sits in our supply chain. Waste and Materials Our approach to product stewardship means that we consider and aim to address impacts on nature and climate at every stage of the product lifecycle, from discovery, design, sourcing and manufacturing through to product use and disposal. We have set a target to help accelerate the adoption of this approach. The effect nature-related dependencies, impacts, risks and opportunities have on our business model, value chain, strategy and financial planning, as well as any transition plans or analysis in place. We are committed to have a net positive impact on nature by 2030 by reducing our environmental impacts across water, waste and materials, biodiversity and by investing in nature protection and restoration. We set targets in 2020 with a focus on the realms of nature, as well as supportive targets on waste and materials. We report progress against our nature plan and targets annually. 71 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Nature-related financial disclosures continued In 2023 we were selected to be one of the first group of companies to work with the Science Based Targets Network (SBTN) in the pilot to develop and set validated science-based targets for nature, starting with targets for freshwater and land, followed by targets for oceans and biodiversity. These targets will focus on locations across our value chain where nature is particularly under pressure. We aim to have pilot science-based targets for nature in 2024. The resilience of our strategy to nature-related risks and opportunities, taking into consideration different scenarios We manage organisational resilience to nature related risks through the implementation of our sustainability programme. Our delivery plan will evolve as external guidance continues to evolve, The locations of our direct operations that meet the criteria for priority locations Freshwater We have identified three initial water basins in water- stressed areas where we have manufacturing sites, including across India, Pakistan and Algeria, which we have prioritised for investment in water neutrality to achieve a measurable and positive impact in water-stressed basins on availability, quality and accessibility. Land Our operational land holdings are relatively small, although two of our R&D sites, one in Belgium and one in Spain, are located in Key Biodiversity Areas. In 2021, we piloted our approach to biodiversity with a baseline assessment and action plans at three sites to improving habitats, protecting species and improving soil and water quality. We have now commenced biodiversity uplift projects at our three largest R&D facilities – Stevenage in the UK and Upper Providence and Upper Merion in Pennsylvania in the US. We are addressing 12 critical agricultural, forestry and marine-derived materials. We have engaged with associated suppliers and external independent experts to map the full supply chains involved, understand existing sustainability standards, identify gaps and establish improvement plans. Oceans We committed to restore mangroves in Indonesia, through community-led projects. Mangroves play a crucial role in climate regulation and climate change mitigation because of their carbon sequestration potential. Mangroves make the local population more resilient to flooding, improve the local fish ecosystem, water quality and contribute to the health and livelihood of local communities. Risk & impact management Our processes for identifying, assessing and prioritising nature-related dependencies, impacts, risks and opportunities in our direct operations and value chain Since 2020 we have deepened our understanding of our full value chain nature impacts and dependencies and continued to align with evolving practices and guidance. We are following the TNFD LEAP (Locate, Evaluate, Assess and Prepare) methodology to better understand our nature-related risks and opportunities and are involved in the pilot working with the Science Based Targets Network (SBTN) to set validated science-based targets for nature, starting with targets for freshwater and land, followed by targets for oceans and biodiversity. Our processes for managing nature-related dependencies, impacts, risks and opportunities We set targets in 2020 with a focus on the realms of nature, as well as supportive targets on waste and materials. We report progress against our nature plan and targets annually. Water Across all of our sites, we maintain high quality water infrastructure to ensure there is no leakage, and we reduce our overall water use through water-efficiency projects, including behaviour change programmes and introducing water-efficient cleaning procedures. Today, all GSK sites complete a GSK water stewardship assessment, aligned to the Alliance for Water Stewardship (AWS) standard, and implement action plans to comply with our standard. For our sites located in water-stressed areas, we aim to secure certification under the AWS standard. Land While we work on avoiding or reducing impact by assessing opportunities to improve efficiency, material changes or switching to alternatives, we have set ambitious standards for suppliers who provide us with materials that are highly dependent on nature, such as sugar, paper, palm oil, lactose, gelatine and soy. These standards, developed in collaboration with third- party experts, aim to support these suppliers to assess, improve, and verify their approach to addressing a range of nature impacts – and associated climate and social impacts – including land use, water stewardship and biodiversity. As a first stage, we are addressing the 12 most critical materials, including paper and palm oil. We have roadmaps in place with an aim to achieve 100% sustainable sourced paper and palm oil by 2025. We have engaged with associated suppliers to map the full supply chains involved, understand existing sustainability standards, identify gaps and establish action plans. We are committed to having positive impact on biodiversity at all our operational sites. We used the Integrated Biodiversity Assessment Tool (IBAT) and have worked with ecological experts to complete mapping and baseline biodiversity assessments for 80% of our sites. We are now implementing biodiversity action plans across our estate with an aim to improve habitats, protect species and improve soil and water quality. 72 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Nature-related financial disclosures continued Oceans To reduce our impact on oceans, we are implementing our Marine Sustainable Sourcing Standard which outlines the specific requirements that our suppliers of marine-derived materials must adhere to. As part of our approach to product stewardship, we are working to reduce the volume of marine-derived materials, for example, through process efficiencies. In the longer term, we are seeking to transition to alternatives to marine- derived materials, wherever possible from both a technical and regulatory perspective. Atmosphere The outcome of an initial air quality assessment highlighted opportunities for reductions in emissions linked to on-site electricity generation and use of solid fuels, car use and move to electric fleet, as well as indicating opportunities in our value chain for the sourcing of plastic and glass products. We are creating reduction plans around these key areas that are aligned to our pathway to net zero and which aim to have a positive impact on air quality. We are conducting an additional air quality assessment, working with Stockholm Environment Institute (SEI) and the University of York, broadening the suite of air pollutants to be taken into consideration to understand their impact across our value chain and their connection to human health. To help accelerate collective action on air pollution, we are members of the Alliance for Clean Air through the Clean Air Fund (CAF) and the World Economic Forum, which aims to drive corporate action on clean air to accelerate climate action and create healthy communities around the world. The collective measurement of direct and value chain emissions across the Clean Air Fund membership aims to build a picture of the activities that give rise to poor air quality globally and intends to enable policy makers and industries to make informed decisions, considering the broader global impacts on health from poor air quality. Waste and materials Embedding our approach to product stewardship to reduce our impact on nature means working to minimise the waste and materials used, and the waste and pollution generated, from delivering our medicines and vaccines across the full product lifecycle. We have already achieved zero operational waste to landfill and we continue to build on our long-standing operational waste management programme to identify opportunities to achieve more beneficial use from waste. However, there is a risk that circular routes of recovery for all our waste streams may still not exist by 2030. For our supply chain, we’re working on a waste footprint assessment to help with supplier engagement on waste reduction, and on product design so we can build in circularity and reduce waste by design. How our processes for identifying, assessing, prioritising and monitoring nature-related risks are integrated into and inform our overall risk management processes We are a part of the first group of companies to be working with the Science Based Targets Network (SBTN) to set validated science-based targets for nature, starting with targets for freshwater and land, followed by targets for oceans and biodiversity. These targets will focus on locations across our value chain where nature is particularly under pressure. We aim to have science-based targets for nature in 2024. We continue to work towards our existing targets while we work through the SBTN pilot. Our delivery plan will continue to evolve as we go through SBTN target validation, as external guidance continues to evolve, and our data is developed, primarily through greater supply chain traceability. Metrics and targets We report performance against our existing targets using metrics for water use and waste and materials see table on page 70. Realm Freshwater Key performance indicator Average of the percentage of GSK sites and suppliers compliant with wastewater active pharmaceutical ingredient limits and the percentage of suppliers that are compliant with the AMR Industry Alliance Common Antibiotic Manufacturing Framework and discharge limits Land The percentage of paper and palm oil that is deforestation free Waste and materials The reduction in routine operational hazardous and non-hazardous waste 73 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Nature-related financial disclosures continued GSK sets the following targets for managing our nature commitments: Focus area Freshwater Land Oceans Atmosphere Waste and materials Target – 100% of our sites to achieve good water stewardship by 2025 and reduce overall water use by 20% by 2030 – Water neutral in operations and with key suppliers in water-stressed regions by 2030 – Zero impact active pharmaceutical ingredient levels1 for all our sites and key suppliers by 20302 – Positive impact on biodiversity at all sites3 by 2030 – 100% of agricultural and forestry derived materials sustainably sourced and deforestation free by 20302,4 – 100% of marine-derived materials sustainably sourced by 2030 – 100% renewable electricity by 2025 (Scope 2)2 – 80% reduction in carbon emissions across our full value chain by 20302 – Net zero carbon emissions across our full value chain by 20452 – Zero operational waste5 10, including eliminating single use plastics6 by 20302 – 10% waste reduction from supply chain by 2030 – 25% environmental impact reduction for our products and packaging by 2030 (1) Below the predicted no-effect level (2) Linked with the remuneration of our senior leaders (3) GSK sites (4) Target updated in December 2021 to reflect priority materials (5) Including a 20% reduction in routine hazardous and non-hazardous waste (6) Where regulatory obligations allow, and excluding plastics which are critical to product discovery and development and health & safety 74 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Non-financial and sustainability information statement The following aligns to the non-financial reporting requirements contained in sections 414CA and 414CB of the Companies Act 2006. Description of the business model Human rights Policy, due diligence and outcomes Business model Social matters Access Global health and health security Employees Our culture and people Employee engagement Wellbeing and development Diversity, equity and inclusion Gender pay gap Ethical standards Board diversity 47 48 14 15 15 52 53 53 130 8 Human rights Working with third parties Data and engagement Anti-bribery and corruption Ethical standards Reporting and investigating concerns Environmental matters Environment Climate-related financial disclosures Nature-related financial disclosures 70 54 54 54 53 54 49 62 Risk management Viability statement 57 76 Audit & Risk Committee report 133 Principal risks and uncertainties 284 Non-financial key performance indicators 2023 performance and key performance indicators 2 Our policies All of our public policies, codes and standards are available on gsk.com Employees by gender Board1 Management1,2 All employees3 Male 7 8,682 36,510 Female 5 8,788 33,702 Total 12 17,470 70,212 (1) Headcounts as of 31 December 2023 (2) Senior managers as defined in the Companies Act 2006 (Strategic Report and Directors’ Report) Regulations 2013 (3) ‘Total’ calculated as full-time equivalent employees (FTEs) as of 31 December 2023. ‘Male’ and ‘female’ calculated by applying ‘all employees’ gender diversity percentages to ‘total’ FTE number 75 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Viability statement In accordance with provision 31 of the 2018 revision of the Code, GSK has assessed the prospects of the Group over a longer period than the 12 months required by the ‘Going Concern’ provision. The Directors confirm that they have a reasonable expectation that GSK will continue to operate and meet its liabilities, as they fall due, over the next three years. The Directors’ assessment has been made with reference to GSK’s current position and prospects, our strategy, the Board’s risk appetite and GSK’s principal risks and how these are managed, as detailed on pages 57 to 61 in the Strategic report. The Board reviews our internal controls and risk management policies and approves our governance structure and code of conduct. It also appraises and approves major financing, investment and licensing decisions, and evaluates and monitors the performance and prospects of GSK as a whole. The focus is largely on improving our long-term financial performance through delivery of our company’s business strategies and aligned priorities. The Board reviews GSK’s strategy and makes significant capital investment decisions over a long-term time horizon, based on a multi-year assessment of return on capital, the performance of the company, and the market opportunities in medicines and vaccines. This approach is aligned to GSK’s model of achieving balanced growth by investing in high quality, innovative products for patients and healthcare providers. However, since many internal and external parameters become increasingly unpredictable over longer time horizons, GSK focuses its detailed, bottom-up Plan on a three-year cycle. The Plan is reviewed at least annually by the Directors, who approve business forecasts showing expected financial impact. The Directors believe that a three-year assessment period for the Viability statement is most appropriate as it aligns with the Group’s well established business planning processes that balance the long-term nature of investments in medicines and vaccines with an assessment of the period over which analysis of near-term business performance is realistically visible. The Plan has been stress tested in a series of robust operational and principal risk downside scenarios as part of the Board’s review on risk. The Plan assumes the next several years to be challenging for the healthcare industry with continued pressure on pricing of pharmaceuticals and uncertain economic conditions prevailing across many markets in which GSK operates. GSK assumes no premature loss of exclusivity for key products over the period and for all anticipated launches to proceed as planned. The downside scenarios consider GSK’s cash flows, sustainability of dividends, funding strategy, insurance provision and recovery as well as other key financial ratios over the period. These metrics have been subject to sensitivity analysis, which involves flexing a number of the main assumptions underlying the forecasts both individually and in combination, along with mitigating actions that could realistically be taken to avoid or reduce the impact or occurrence of the underlying risk. The following hypothetical downside scenarios have been evaluated: Scenario 1: Business performance risks. These include key performance risks, including lower sales from new products, greater adverse impact from generic competition and other competitive launches to other GSK products, as well as possible supply and manufacturing challenges. Scenario 2: External and macroeconomic risks. This scenario reflects incremental risks to the business driven by outside factors, such as more intense competition, increased pricing pressure in both the US and Europe as well as the potential impact of material negative changes in the macro- economic and healthcare environment. Scenario 3: Principal risks. This scenario includes a severe assessment of the potential loss impact from the principal risks related to patient safety, product quality, supply chain continuity, information and cyber security and environmental harm as well as anti-bribery and corruption and any consequent regulatory actions, fines or significant litigation, all of which could fundamentally threaten our operations. These risks are managed through mitigating activities described on pages 284 to 294. Scenario 4: Put option exercise. This scenario evaluates the additional funding requirements assuming the earliest potential exercise of the outstanding put option held by Pfizer Inc. The three-year review also makes certain assumptions about the normal level of capital recycling likely to occur and considers whether additional financing facilities will be required and the respective level of funding flexibility and headroom. The results of this stress testing show that certain combinations of these hypothetical scenarios could increase funding demands on GSK and require mitigating changes to the Group’s funding strategy. However, in light of the liquidity available to the Group and based on this analysis, the Directors have a reasonable expectation that, even under these most severe stress tests, the Group will be able to continue in operation and meet its liabilities as they fall due over the three-year period of assessment. 76 GSK Annual Report 2023 Group financial review In this section Summary full year results Financial performance summary Reporting framework Financial performance Adjusting items Cash generation and conversion Financial position and resources Approach to tax Treasury policies Critical accounting policies 78 81 82 86 93 97 98 103 104 105 77 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review Summary full year results Results summary Turnover Turnover excluding COVID-19 solutions Total continuing operating profit Total operating margin Total continuing EPS Adjusted operating profit Adjusted operating margin Adjusted EPS Cash flow Cash generated from operations Free cash flow Full year 2023 £m Growth AER % Growth CER % Full year 2022 £m Full year 2021 £m 30,328 30,134 6,745 22.2% 121.6p 8,786 29.0% 155.1p 8,096 3,409 3 12 5 5 14 10 0.3ppts 1.0ppts 10 8 16 12 1.2ppts 1.8ppts 16 11 2 2 29,324 24,696 26,951 6,433 21.9% 110.8p 8,151 27.8% 139.7p 7,944 3,348 23,291 4,357 17.6% 82.9p 6,493 26.3% 110.3p 7,249 3,301 (2023 Financial results unless otherwise stated, growth % and commentary at CER. Ex COVID is excluding COVID-19 solutions as defined on page 85). GSK delivered an excellent performance in 2023 with sales of £30.3 billion and double digit adjusted operating profit and adjusted EPS per share growth at CER. As a consequence of this performance, we were also pleased to increase the dividend for the year. In 2024, we expect another year of meaningful growth for GSK, driven by a continued focus on execution, strengthening our pipeline and capital allocation. Total continuing EPS grew 16%, reflecting strong profit growth and lower charges related to the remeasurement of contingent consideration liabilities, partly offset by a fair value loss on the retained stake in Haleon plc compared to a fair value gain in the same period in the prior year. In addition, there is an unfavourable comparison due to upfront income received from the settlement with Gilead Sciences Inc. in 2022. Adjusted EPS grew 16% overall (with further positive impact of +6% excluding COVID-19 solutions), benefiting from a lower net finance expense, which decreased 15% following debt restructuring. The effective adjusted tax rate was 15.5% in line with 2022 and our guidance. Improved 2023 operating margins Total operating profit margin was higher in 2023 due to profitable growth across the portfolio, favourable movements in contingent consideration liabilities, partly offset by an unfavourable comparison due to upfront income received from the settlement with Gilead Sciences Inc. in 2022. Adjusted operating profit margin improved primarily due to reduced sales of lower-margin Xevudy. Excluding COVID-19 solutions, Adjusted operating profit margin improved due to product mix, productivity improvements and increased royalty income. Growth in SG&A reflected investment in Vaccines, including disease awareness and the launch of Arexvy, together with Shingrix, long-acting HIV, Jemperli and Ojjaara. Royalty income also contributed to margin improvement. 78 Delivering a step-change in financial performance in 2023 In 2023 our sales were £30,328 million, an increase of 5% overall reflecting continued strong business performance with strong growth in Vaccines (Arexvy and Shingrix) and HIV, excluding COVID-19 solutions sales grew 14%. Total operating profit increased 10% to £6,745 million, driven by overall performance and favourable contingent consideration liabilities (CCL) movements. Adjusted operating profit grew 12% to £8,786 million (with further positive impact of +4% excluding COVID-19 solutions). Adjusted operating margin increased to 29%, driven largely by favourable product mix and operational efficiencies, as well as increased royalties. The reconciliation of Total to Adjusted results is included on page 93. Total and adjusted cost of sales as a percentage of sales decreased in the full year reflecting reduced sales of lower margin Xevudy compared to 2022. Total and adjusted SG&A growth was focused on investment in Vaccines, including disease awareness and the launch of Arexvy, together with Shingrix, long-acting HIV, Jemperli and Ojjaara. R&D costs increased due to investment in late-stage programmes in Vaccines, Respiratory/Immunology and Infectious diseases. Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued 2023 cash flow performance Our total full year Cash Generated From Operations increased to £8,096 million despite annualising the Gilead Sciences Inc. settlement in Quarter 1 2022 (£0.9 billion) due to higher Adjusted operating profit, favourable timing of Xevudy cash flows and lower UK pension contributions partly offset by higher receivables from Arexvy sales. Net capital investment increased primarily due to lower proceeds from asset disposals than in 2022 resulting in Free Cash Flow from continuing operations increasing to £3,409 million. Net Debt improvement Our net debt position decreased to £15 billion by the end of 2023. We look to deploy funds to enhance growth and deliver attractive shareholder returns. We started the year with net debt of £17.2 billion and strong free cash generation, in addition to the monetisation of our stake in Haleon plc, supported £3.8 billion of investment in targeted business development and capital expenditure and £2.2 billion was returned to shareholders via the dividend. Capital deployment supports business growth and shareholder returns (1) Free Cash Flow (FCF) is £3.4bn, including the capital expenditure (net of disposal proceeds for plant, property & equipment) and intangibles of £1.3bn and £1.0bn (2) Other includes dividend and distribution income, exchange on net debt and other financing items Capital allocation framework to support investment and returns Priority is to invest for growth, coupled with attractive shareholder returns (1) GSK group dividend in 2022; GSK related only and excludes dividend related to Consumer Healthcare in H1-2022; FY 2022 dividend 61.25p/share Our capital allocation framework to support investment and returns Our capital allocation framework means our first priority remains to invest in the business, with capital allocated towards development of the pipeline, both organic and targeted business development. We also remain committed to delivering attractive returns to shareholders and pursuing a progressive dividend policy, guided by a 40 to 60 percent pay-out ratio through the investment cycle. In setting its dividend policy, GSK considers the priorities of the Group and its investment strategy for growth, alongside the sustainability of the dividend. Consistent with this, and reflecting strong business performance during the year, GSK now expects to declare an increased dividend of 58.00p per share for full year 2023. The expected dividend for 2024 is 60.00p. In the event of surplus cash, the excess would be returned to shareholders. We remain committed to maintaining a balance sheet with a strong investment grade credit rating. 79 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 2021-26 and 2031 Outlooks at CER In January 2024, GSK announced upgraded outlooks, from those previously given, for the period 2021-2026 and for 2031. For the period 2021-2026, GSK now expects sales to grow more than 7% on a CAGR basis and adjusted operating profit to increase more than 11%, on the same basis. This compares to previous outlooks of more than 5% and more than 10% respectively. Adjusted operating profit margin in 2026 is now expected to be more than 31%. By 2031, GSK now expects to achieve sales of more than £38 billion on a risk-adjusted basis and at CER. GSK expects to maintain a continued strong focus on margin improvements, while retaining flexibility to invest in future growth. Recognising that GSK will likely face loss of exclusivity for dolutegravir during 2028 to 2030 in the US and EU, with the majority of impact 2029 to 2030, GSK stated that it expects operating margins to be broadly stable through this period. GSK expects an effective transition within its HIV portfolio towards new long-acting treatment and prevention therapies, margin mix benefit from growth in higher operating margin Vaccine and Specialty Medicine products, and a continued focus on achievable productivity gains, notably in supply chain and in SG&A. All expectations, guidance and outlooks regarding future performance and dividend payments should be read together with ‘Guidance and outlooks, assumptions and cautionary statements’ on inside back cover. Group financial review continued 2024 guidance at CER (excluding COVID-19 solutions) For 2024, we expect another year of meaningful growth for GSK, our guidance is provided at CER and excludes the impact of COVID-19 solutions. Sales are expected to increase between 5 and 7 per cent, Adjusted operating profit is expected to increase between 7 and 10 per cent with Adjusted earnings per share expected to increase between 6 and 9 per cent. This guidance is supported by the following turnover expectations for full year 2024: – For Vaccines, we expect high single digit to low double- digit percent growth – For Specialty Medicines, we expect a low double-digit per cent growth – For General Medicines, we expect sales will decrease by a mid-single-digit per cent Adjusted Operating profit is expected to grow between 7 to 10 per cent at CER, despite a 6 percentage point impact to Operating Profit growth following the loss of Gardasil royalties effective from the beginning of 2024. GSK expects to deliver leverage at a gross margin level due to improved product mix from Vaccines and Specialty Medicines growth and continued operational efficiencies. In addition, GSK anticipates further leverage in Operating Profit due to a step down in SG&A growth to a low single-digit increase. R&D is expected to increase broadly in line with sales to support growth of the pipeline. Adjusted Earnings per share is now expected to increase between 6 to 9 per cent at CER, reflecting higher operating profit and more favourable net finance costs. Expectations for non-controlling interests remain unchanged relative to 2023, and GSK anticipates, as previously communicated, an increase in the adjusted effective tax rate to around 17% following implementation of a global minimum corporate income tax rate aligned with the Organisation for Economic Co-Operation and Development ‘Pillar 2’ initiative. COVID-19 solutions We do not anticipate any future revenue from COVID-19 solutions and this will reduce sales growth by 1% and Adjusted operating profit growth by 2% in 2024. Currency impact If exchange rates were to hold at the closing rates on 24 January 2024 ($1.27/£1, €1.17/£1 and Yen 188/£1) for the rest of 2024, the estimated impact on 2024 Sterling turnover growth for GSK would be -3% and if exchange gains or losses were recognised at the same level as in 2023, the estimated impact on 2024 Sterling Adjusted Operating Profit growth for GSK would be -5%. 80 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance summary The Total results of the Group are set out below. Turnover Cost of sales Gross profit Selling, general and administration Research and development Royalty income Other operating income/(expense) Operating profit Net finance costs Share of after tax profits/(losses) of associates and joint ventures Profit/(loss) on disposal of interest in associates and joint ventures Profit before taxation Taxation Profit after taxation from continuing operations Profit after taxation from discontinued operations and other gains/(losses) from the demerger Remeasurement of discontinued operations distributed to shareholders on demerger Profit after taxation from discontinued operations Total profit after taxation for the year Profit attributable to non-controlling interests from continuing operations Profit attributable to shareholders from continuing operations Profit attributable to non-controlling interests from discontinued operations Profit attributable to shareholders from discontinued operations Total profit attributable to non-controlling interests Total profit attributable to shareholders Earnings per share from continuing operations (pence) Earnings per share from discontinued operations (pence) Total earnings per share (pence) Earnings per ADS from continuing operations (US$) Earnings per ADS from discontinued operations (US$) Total earnings per ADS (US$) 2023 % of turnover 100 £m 29,324 (28.2) (9,554) 71.8 19,770 (30.9) (8,372) (20.5) 3.1 (5,488) 758 (1.3) (235) 22.2 6,433 (803) (2) – 5,628 (707) 4,921 3,049 7,651 10,700 15,621 460 4,461 205 10,495 15,621 665 14,956 15,621 110.8p 260.6p 371.4p 2.75 6.46 9.21 £m 30,328 (8,565) 21,763 (9,385) (6,223) 953 (363) 6,745 (677) (5) 1 6,064 (756) 5,308 – – – 5,308 380 4,928 – – 5,308 380 4,928 5,308 121.6p – 121.6p 3.02 – 3.02 2022 % of turnover 100 (32.6) 67.4 (28.6) (18.7) 2.6 (0.8) 21.9 Growth CER% 5 (10) 13 14 14 26 10 14 14 £% 3 (10) 10 12 13 26 5 8 8 (100) (100) (66) (64) (66) 10 (100) (67) (64) 16 (100) (65) The Adjusted results for the Group are set out below. Reconciliations between Total results and Adjusted results for 2023 and 2022 are set out on pages 93 to 94. Turnover Cost of sales Selling, general and administration Research and development Royalty income Adjusted operating profit Adjusted profit attributable to non-controlling interest Adjusted profit attributable to shareholders Adjusted profit after taxation Adjusted earnings per share (p) £m 30,328 (7,716) (9,029) (5,750) 953 8,786 572 6,283 6,855 155.1p 2023 % of turnover 100 £m 29,324 (25.4) (8,741) (29.8) (19.0) (8,128) (5,062) 3.2 29.0 758 8,151 595 5,625 6,220 139.7p 2022 % of turnover Growth £% CER% 100 (29.8) (27.7) (17.3) 2.6 27.8 3 (12) 11 14 26 8 10 11 5 (11) 13 14 26 12 15 16 81 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Reporting framework Total and Adjusted results The Group financial review discusses the operating and financial performance of the Group, its cash flows and financial position and our resources. The results for each year are compared primarily with the results of the preceding year. Total results Total reported results represent the Group’s overall performance. GSK also uses a number of adjusted, non-IFRS, measures to report the performance of its business. Adjusted results and other non-IFRS measures may be considered in addition to, but not as a substitute for or superior to, information presented in accordance with IFRS. Adjusted results are defined below and other non-IFRS measures are defined on page 83. GSK believes that Adjusted results, when considered together with Total results, provide investors, analysts and other stakeholders with helpful complementary information to understand better the financial performance and position of the Group from period to period, and allow the Group’s performance to be more easily compared against the majority of its peer companies. These measures are also used by management for planning and reporting purposes and when determining compensation. They may not be directly comparable with similarly described measures used by other companies. GSK encourages investors and analysts not to rely on any single financial measure but to review GSK’s Annual Reports, including the financial statements and notes, in their entirety. Adjusted results Adjusted results exclude the profits from discontinued operations from the Consumer Healthcare business (see details on page 238) and the following items in relation to our continuing operations from Total results, together with the tax effects of all of these items: – amortisation of intangible assets (excluding computer software and capitalised development costs) – impairment of intangible assets (excluding computer software) and goodwill – Major restructuring costs, which include impairments of tangible assets and computer software, (under specific Board approved programmes that are structural, of a significant scale and where the costs of individual or related projects exceed £25 million) including integration costs following material acquisitions – transaction-related accounting or other adjustments related to significant acquisitions – proceeds and costs of disposals of associates, products and businesses; significant settlement income; significant legal charges (net of insurance recoveries) and expenses on the settlement of litigation and government investigations; other operating income other than royalty income, and other items Costs for all other ordinary course smaller scale restructuring and legal charges and expenses are retained within both Total and Adjusted results. As Adjusted results include the benefits of Major restructuring programmes but exclude significant costs (such as amortisation of intangible assets except for computer software and capitalised development costs, significant legal, major restructuring and transaction items), they should not be regarded as a complete picture of the Group’s financial performance, which is presented in its Total results. The exclusion of other Adjusting items may result in Adjusted earnings being materially higher or lower than Total earnings. In particular, when significant impairments, restructuring charges and legal costs are excluded, Adjusted earnings will be higher than Total earnings. GSK has undertaken a number of Major restructuring programmes in response to significant changes in the Group’s trading environment or overall strategy or following material acquisitions. Within the Pharmaceuticals sector, the highly regulated manufacturing operations and supply chains and long lifecycle of the business mean that restructuring programmes, particularly those that involve the rationalisation or closure of manufacturing or R&D sites are likely to take several years to complete. Costs, both cash and non-cash, of these programmes are provided for as individual elements are approved and meet the accounting recognition criteria. As a result, charges may be incurred over a number of years following the initiation of a Major restructuring programme. Significant legal charges and expenses are those arising from the settlement of litigation or government investigations that are not in the normal course and are materially larger than more regularly occurring individual matters. They also include certain major legacy matters. Reconciliations between Total and Adjusted results, providing further information on the key Adjusting items for 2023, 2022 and 2021, are set out on pages 93 to 95. GSK provides earnings guidance to the investor community on the basis of Adjusted results. This practice is in line with peer companies and expectations of the investor community, supporting easier comparison of the Group’s performance with its peers. GSK is not able to give guidance for Total results as it cannot reliably forecast certain material elements of the Total results, particularly the future fair value movements on contingent consideration and put options that can and have given rise to significant adjustments driven by external factors such as currency and other movements in capital markets. 82 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Reporting framework continued Historical record of Adjusting items The reconciliations between Total and Adjusted operating profit from continuing operations over the last three years can be summarised as follows: Total operating profit from continuing operations Intangible amortisation Intangible impairment Major restructuring Transaction-related items Divestments, significant legal and other items Adjusted results 2023 £m 6,745 719 398 382 572 2022 £m 6,433 739 296 321 1,750 (30) (1,388) 2021 £m 4,357 761 347 424 1,143 (539) 8,786 8,151 6,493 The analysis of the impact of transaction-related items on operating profit for each of the last three years is as follows: Contingent consideration on former Shionogi-ViiV Healthcare JV (including Shionogi preferential dividends) ViiV Healthcare put options and Pfizer preferential dividends Contingent consideration on former Novartis Vaccines business Contingent consideration on acquisition of Affinivax Other adjustments Transaction-related items 2023 £m 934 (245) (187) 44 26 572 2022 £m 1,431 85 193 17 24 2021 £m 1,026 48 27 – 42 1,750 1,143 Full reconciliations between Total and Adjusted results for 2021–2023 including continuing and discontinued operations are set out on pages 93 to 95. Further explanations on the Adjusting items for 2023 are reported on page 96. Return on capital employed Return on capital employed is calculated as total profit before taxation as a percentage of average net assets over the year. Total net debt Net debt is defined as total borrowings less cash, cash equivalents, liquid investments, and short-term loans to third parties that are subject to an insignificant risk of change in value. Please see Note 30 ‘Net Debt’ for the calculation of net debt. Total Operating Margin Total operating margin is operating profit divided by turnover. Adjusted Operating Margin Adjusted operating margin is Adjusted operating profit divided by turnover. Compound Annual Growth Rate (CAGR) CAGR is defined as the compound annual growth rate and shows the annualised average rate of revenue growth between a number of given years, assuming growth takes place at an exponentially compounded rate. Other non-IFRS measures Free cash flow Free cash flow is defined as the net cash inflow/outflow from continuing operating activities less capital expenditure on property, plant and equipment and intangible assets, contingent consideration payments, net finance costs, and dividends paid to non-controlling interests, contributions from non-controlling interests plus proceeds from the sale of property, plant and equipment and intangible assets, and dividends received from joint ventures and associates (all attributable to continuing operations). It is used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies. Free cash flow growth is calculated on a reported basis. A reconciliation of net cash inflow from continuing operations to free cash flow from continuing operations is set out on page 97. Working capital Working capital represents inventory and trade receivables less trade payables. CER and AER growth In order to illustrate underlying performance, it is the Group’s practice to discuss its results in terms of constant exchange rate (CER) growth. This represents growth calculated as if the exchange rates used to determine the results of overseas companies in Sterling had remained unchanged from those used in the comparative period. CER% represents growth at constant exchange rates. £% or AER% represents growth at actual exchange rates. 83 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Reporting framework continued Non-controlling interests in ViiV Healthcare Trading profit allocations As ViiV Healthcare is a subsidiary of the Group, 100% of its operating results (turnover, operating profit, profit after tax) are included within the Group income statement and then a portion of the earnings is allocated to the non-controlling interests owned by the other shareholders, in line with their respective equity shareholdings (Pfizer, Inc. (Pfizer) 11.7% and Shionogi & Co. Ltd (Shionogi) 10%). Each of the shareholders, including GSK, is also entitled to preferential dividends determined by the performance of certain products that each shareholder contributed. As the relative performance of these products changes over time, the proportion of the overall earnings allocated to each shareholder also changes. In particular, the increasing proportion of sales of dolutegravir- and cabotegravir-containing products has a favourable impact on the proportion of the preferential dividends that is allocated to GSK. Adjusting items are allocated to shareholders based on their equity interests. GSK was entitled to approximately 84% of the Total earnings and 83% of the Adjusted earnings of ViiV Healthcare for 2023. Remeasurements of the liabilities for the preferential dividends allocated to Pfizer and Shionogi are included within other operating income/(expenses). Acquisition-related arrangements As consideration for the acquisition of Shionogi’s interest in the former Shionogi-ViiV Healthcare joint venture in 2012, Shionogi received the 10% equity stake in ViiV Healthcare and ViiV Healthcare also agreed to pay additional future cash consideration to Shionogi, contingent on the future sales performance of the products being developed by that joint venture, dolutegravir and cabotegravir. Under IFRS 3 `Business combinations’, GSK was required to provide for the estimated fair value of this contingent consideration at the time of acquisition and is required to update the liability to the latest estimate of fair value at each subsequent period end. The liability for the contingent consideration recognised in the balance sheet at the date of acquisition was £659 million. Subsequent re-measurements are reflected within other operating income/(expenses) and within Adjusting items in the income statement in each period. Cash payments to settle the contingent consideration are made to Shionogi by ViiV Healthcare each quarter, based on the actual sales performance and other income of the relevant products in the previous quarter. These payments reduce the balance sheet liability and hence are not recorded in the income statement, but are included in the cash flow. The cash payments made to Shionogi by ViiV Healthcare in 2023 were £1,106 million. As the liability is required to be recorded at the fair value of estimated future payments, there is a significant timing difference between the charges that are recorded in the Total income statement to reflect movements in the fair value of the liability and the actual cash payments made to settle the liability. The cash payments are reflected in the cash flow statement partly in operating cash flows and partly within investing activities. The tax relief on these payments is reflected in the Group’s Adjusting items as part of the tax charge. The part of each payment relating to the original estimate of the fair value of the contingent consideration on the acquisition of the Shionogi-ViiV Healthcare joint venture in 2012 of £659 million is reported within investing activities in the cash flow statement and the part of each payment relating to the increase in the liability since the acquisition is reported within operating cash flows. Movements in contingent consideration payable to Shionogi were as follows: Contingent consideration at beginning of the year Remeasurement through income statement and other movements Cash payments: operating cash flows Cash payments: investing activities Contingent consideration at end of the year 2023 £m 2022 £m 5,890 5,559 934 (1,106) – 5,718 1,431 (1,031) (69) 5,890 Of the contingent consideration payable (on a post-tax basis) to Shionogi at 31 December 2023, £1,017 million (31 December 2022: £940 million) is expected to be paid within one year. Exit rights Pfizer may request an IPO of ViiV Healthcare at any time and if either GSK does not consent to such IPO or an offering is not completed within nine months, Pfizer could require GSK to acquire its shareholding. Under the original agreements, GSK had the unconditional right, so long as it made no subsequent distribution to its shareholders, to withhold its consent to the exercise of the Pfizer put option and, as a result, in accordance with IFRS, GSK did not recognise a liability for the put option on its balance sheet. However, during Q1 2016, GSK notified Pfizer that it had irrevocably given up this right and accordingly recognised the liability for the put option on the Group’s balance sheet during Q1 2016 at an initial value of £1,070 million. Consistent with this revised treatment, at the end of Q1 2016 GSK also recognised liabilities for the future preferential dividends anticipated to become payable to Pfizer and Shionogi on the Group’s balance sheet. Pfizer has the right to require GSK to acquire its shareholding in ViiV Healthcare in certain circumstances at any time. A put option liability is therefore recorded on the Group’s balance sheet as a current liability. It is measured on the gross redemption basis derived from an internal valuation of the ViiV Healthcare business. The closing balances of the liabilities related to Pfizer’s shareholding are as follows: Pfizer put option 2023 £m 848 2022 £m 1,093 84 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Reporting framework continued Under the original agreements, Shionogi could also have requested GSK to acquire its shareholding in ViiV Healthcare in six-month windows commencing in 2017, 2020 and 2022. GSK had the unconditional right, so long as it made no subsequent distribution to its shareholders, to withhold its consent to the exercise of the Shionogi put option and, as a result, GSK did not recognise a liability for the put option on its balance sheet. However, during Q1 2016, GSK notified Shionogi that it had irrevocably given up this right and accordingly recognised the liability for the put option on the Group’s balance sheet during Q1 2016 at an initial value of £926 million. In Q4 2016, Shionogi irrevocably agreed to waive its put option and, as a result, GSK de-recognised the liability for this put option on the Group’s balance sheet directly to equity. The value of the liability was £1,244 million when it was de-recognised. GSK also has a call option over Shionogi’s shareholding in ViiV Healthcare, which under the original agreements was exercisable in six-month windows commencing in 2027, 2030 and 2032. GSK has now irrevocably agreed to waive the first two exercise windows, but the last six-month window in 2032 remains. As this call option is at fair value, it has no value for accounting purposes. Specialty Medicines Specialty Medicines are typically prescription medicines used to treat complex or rare chronic conditions. For GSK, this comprises medicines in infectious diseases, HIV, Oncology, Respiratory/Immunology and Other. Share Consolidation Following completion of the Consumer Healthcare business demerger on 18 July 2022, GSK plc Ordinary shares were consolidated to maintain share price comparability before and after demerger. Shareholders received 4 new Ordinary shares with a nominal value of 31¼ pence each for every 5 existing Ordinary shares which had a nominal value of 25 pence each. Earnings per share, diluted earnings per share, adjusted earnings per share and dividends per share were retrospectively adjusted to reflect the Share Consolidation in all the periods presented. Earnings per share Earnings per share has been retrospectively adjusted for the Share Consolidation on 18 July 2022, applying a ratio of 4 new Ordinary shares for every 5 existing Ordinary shares. Reporting definitions Total Earnings per share COVID-19 solutions COVID-19 solutions include the sales of pandemic adjuvant and other COVID-19 solutions including vaccine manufacturing and Xevudy and the associated costs but does not include reinvestment in R&D. This categorisation is used by management and we believe is helpful to investors through providing clarity on the results of the Group by showing the contribution to growth from COVID-19 solutions. Turnover excluding COVID-19 solutions Turnover excluding COVID-19 solutions excludes the impact of sales of pandemic adjuvant within Vaccines and Xevudy within Specialty Medicines related to the COVID-19 pandemic. Management believes that the exclusion of the impact of these COVID-19 solutions sales aids comparability in the reporting periods and understanding of GSK’s growth including by region versus prior periods and also 2024 Guidance which excludes any contributions from COVID-19 solutions. Adjusted operating profit excluding COVID-19 solutions Adjusted operating profit excludes the impact of Commercial Operations COVID-19 solutions for Xevudy and pandemic adjuvant. Adjusted earnings per share excluding COVID-19 solutions Adjusted earnings per share excludes the impact of Commercial Operations COVID-19 solutions for Xevudy and pandemic adjuvant. General Medicines General medicines are usually prescribed in the primary care or community settings by general healthcare practitioners. For GSK, this includes medicines in inhaled respiratory, dermatology, antibiotics and other diseases. Unless otherwise stated, Total earnings per share refers to Total basic earnings per share. RAR (Returns and Rebates) GSK sells to customers, both commercial and government mandated contracts, with reimbursement arrangements that include rebates, chargebacks and a right of return for certain pharmaceutical products principally in the US. Revenue recognition reflects gross-to-net sales adjustments as a result. These adjustments are known as the RAR accruals and are a source of significant estimation, uncertainty and fluctuation which can have a material impact on reported revenue from one accounting period to the next. Total Operating Margin Total Operating margin is Total operating profit divided by turnover. Adjusted Operating Margin Adjusted operating margin is Adjusted operating profit divided by turnover. Discontinued operations Consumer Healthcare was presented as a discontinued operation from Q2 2022. The demerger of Consumer Healthcare was completed on 18 July 2022. The Group Income Statement and Group Cash Flow Statement distinguish discontinued operations from continuing operations. Percentage points Percentage points of growth which is abbreviated to ppts. Non-controlling interest Non-controlling interest is the equity in a subsidiary not attributable, directly or indirectly, to a parent. Brand names and partner acknowledgements Brand names appearing in italics throughout this document are trademarks of GSK or associated companies or used under licence by the Group. 85 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Financial performance Group turnover Group turnover was £30,328 million in the year, up 3% at AER, 5% at CER. In 2023 sales grew 12% at AER, 14% CER excluding COVID-19 solutions. Group turnover by business l Vaccines £9.9bn AER growth 24% CER growth 25% l Speciality Medicines £10.2bn AER decline -9% CER decline -8% l General Medicines £10.2bn AER growth 1% CER growth 5% Group turnover by geographic region l US £15.8bn AER growth 9% CER growth 9% l Europe £6.6bn AER growth 3% CER growth 2% l International £7.9bn AER decline -6% CER growth 1% Vaccines Turnover (£bn) £9.9bn 32% of Group turnover AER growth 24% CER growth 25% Vaccines turnover Vaccines turnover excluding COVID-19 solutions £9.7bn AER growth 23% CER growth 24% Pandemic turnover £0.2bn AER growth >100 CER growth >100 Double-digit growth for Vaccines in the full year was driven by the successful launch of Arexvy in the US and continued strong uptake of Shingrix in International and Europe. Pandemic vaccines sales mostly include GSK’s share of 2023 contracted European volumes related to a COVID-19 booster vaccine co- developed with Sanofi. Shingles Shingles 2023 £m 2022 £m Growth £% Growth CER% 3,446 2,958 16 17 GSK reports results under two segments namely Commercial Operations and Total R&D. See Note 6, 'Turnover and segment information' to the consolidated financial statements for more details. The Commercial Operations segment has three product groups of Vaccines, Specialty Medicines, and General Medicines. – Vaccines products, which includes sales of Shingrix and Arexvy – Specialty Medicines products which includes GSK’s marketed products for HIV, oncology, respiratory/immunology and other specialty medicines (including Nucala) – General Medicines products, which include products previously reported as Established Pharmaceuticals and sales of Trelegy Ellipta and Anoro Ellipta (previously reported within the Respiratory category under Specialty products). These products are typically accessed by patients through primary care settings Shingrix, a vaccine against herpes zoster (shingles), grew 16% AER, 17% CER on increased demand and favourable pricing. Growth was driven by public funding expansion and strong private uptake in International and Europe. These regions represented 45% of global turnover, compared to a third in 2022, with Shingrix launched in 39 markets outside of the US, most of which have cumulative immunisation rates below 4%. International sales were driven by launch uptake across several markets, strong momentum and channel inventory build in China due to transition between distributors, and a new public programme in Australia. Sales in Europe included deliveries for the UK National Immunisation Programme which began offering Shingrix vaccination in September 2023. In the US, retail demand grew 7% while overall sales declined 4% versus a challenging comparator period in which there was a higher non-retail purchasing. The US cumulative immunisation penetration at the end of Q3 2023 reached 35% of the more than 120 million US adults(1) who are currently recommended to receive Shingrix, up 7 percentage points since the same time last year. (1) United States Census Bureau, International Database, Year 2023 86 6.87.99.9202120222023 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Meningitis Meningitis 2023 £m 1,260 2022 £m 1,116 Growth £% Growth CER% 13 14 Turnover (£bn) Specialty Medicines Double-digit Meningitis vaccine sales growth was largely delivered by Bexsero, a vaccine against meningitis B, primarily driven by inclusion in National Immunisation Programmes in Europe. Menveo, a vaccine against meningitis ACWY, grew due to the favourable impact of a US CDC (Center for Disease Control) stockpile borrow in Q3 2022 and replenishment in Q4 2023. Meningitis growth benefitted from the favourable impact of CDC stockpile movements by 6 percentage points. RSV RSV (Arexvy) 2023 £m 1,238 2022 £m – Growth £% Growth CER% – – Arexvy, the world’s first approved respiratory syncytial virus (RSV) vaccine for older adults, achieved more than £1.2 billion in sales driven by strong uptake and leading market share, delivering an outstanding launch. Almost all sales were in the US where Arexvy is available in all major retail pharmacies with competitive contracting in place. Retailers administered more than 90% of doses, and Arexvy achieved more than two-thirds of the share of retail vaccinations. Approximately 6 million of the 83 million US adults(1) aged 60 and older at risk have been vaccinated with Arexvy. £10.2bn AER decline -9% CER decline -8% 34% of Group Turnover Specialty Medicines turnover Specialty turnover excluding COVID-19 solutions £10.2bn AER growth 14% CER growth 15% Pandemic turnover £0.04bn AER decline -98% CER decline -98% Specialty Medicines growth (excluding COVID-19 solutions) of 14% AER, 15% CER reflected continued growth momentum on the HIV portfolio, and growth acceleration in both Oncology and Respiratory/Immunology and Other. COVID-19 solutions negatively impacted growth by 23 percentage points. Influenza Influenza 2023 £m 504 2022 £m 714 Growth £% Growth CER% (29) (29) HIV HIV 2023 £m 2022 £m Growth £% Growth CER% 6,444 5,749 12 13 Fluarix/FluLaval sales declined in 2023 in line with expectations driven by competitive pressure and lower market demand primarily in the US. Established Vaccines Established Vaccines 3,266 3,085 6 7 2023 £m 2022 £m Growth £% Growth CER% Established Vaccines growth was driven by Rotarix favourable US CDC stockpile movements, MMR/V vaccines increased supply in International, and Hepatitis vaccine performance related to the travel market recovery. Established Vaccines growth excluding the impact of CDC stockpile movements was 4%. (1) United States Census Bureau, International Database, Year 2023 The growth of HIV was primarily driven by a 2 percentage point increase in market share within a broadly flat global treatment market, attributable to patient demand for the Oral 2DR (Dovato, Juluca) and Long-Acting medicines (Cabenuva, Apretude). Growth was driven by patient demand of ten percentage points, with the remainder from favourable pricing dynamics and tender growth. Dovato continues to be the highest selling product in the HIV portfolio. Oral 2DR and Long Acting 2023 £m 2022 £m Growth £% Growth CER% Oral 2DR and Long Acting 3,337 2,392 40 40 Oral 2DR (Dovato, Juluca) and Long-Acting medicine (Cabenuva, Apretude) sales growth continues and by the end of the year represented 55% of the total HIV portfolio compared to 46% for Q4 2022, driven by market share growth of 4 percentage points versus Q4 2022. 87 8.311.310.2202120222023 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Respiratory/Immunology and other General Medicines 2023 £m 2022 £m Growth £% Growth CER% Respiratory/Immunology and Other 3,025 2,609 16 18 This therapy area includes sales of Nucala and Benlysta, and Jesduvroq in the US and Duvroq in Japan for patients with anaemia due to chronic kidney disease. There was consistent and sustained double-digit growth in both Benlysta and Nucala. Turnover (£bn) £10.2bn 34% of Group turnover AER growth 1% CER growth 5% Nucala Nucala 2023 £m 2022 £m Growth £% Growth CER% 1,655 1,423 16 18 Nucala, is an IL-5 antagonist monoclonal antibody treatment for severe asthma, with additional indications including chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). Continued strong growth in all regions reflected high patient demand in severe eosinophilic asthma, and additionally from increasing sales and growth contributions from the new indications. Benlysta Benlysta 2023 £m 1,349 2022 £m 1,146 Growth £% Growth CER% 18 19 Benlysta, a monoclonal antibody treatment for Lupus, continues to show consistent growth representing strong demand in US and Europe, with bio penetration and volume uptake in certain International markets, particularly in Japan and China. Oncology Oncology 2023 £m 731 2022 £m 602 Growth £% Growth CER% 21 23 Oncology demonstrated strong growth driven by Jemperli and Zejula performance, and uptake of Ojjaara post US launch in Q3 2023, partially offset by the impact of Blenrep withdrawal from the US market in November 2022. Growth was driven by both Respiratory and Other General Medicines, with ongoing strong demand for Trelegy in all regions, Anoro in Europe and International, and a continued post pandemic recovery of the antibiotic market in Europe and International regions. Respiratory Respiratory 2023 £m 2022 £m Growth £% Growth CER% 6,825 6,548 4 6 Performance reflected growth of Trelegy and the single inhaled triple therapy class across all regions, and of Anoro in Europe and International. Trelegy Trelegy 2023 £m 2,202 2022 £m 1,729 Growth £% Growth CER% 27 29 Trelegy is the most prescribed single inhaler triple therapy (SITT) treatment worldwide for COPD and asthma. Strong growth was delivered across all regions, reflecting increased patient demand, growth of the SITT market and penetration of the class. Growth momentum continues, supported by the outputs of recently updated primary care guidelines from the Global Initiative for Chronic Obstructive Lung Disease. Seretide/Advair Zejula Zejula 2023 £m 523 2022 £m 463 Growth £% Growth CER% 13 15 Seretide/Advair 2023 £m 1,139 2022 £m 1,159 Growth £% Growth CER% (2) 1 Zejula, a PARP inhibitor treatment for ovarian cancer, grew 15% with strong growth from all regions, with US growth in the first line indication more than offsetting the reduction in use in second line following the update to US prescribing information agreed with the FDA in Q4 2022. Seretide/Advair is an ICS/LABA treatment for asthma and COPD. Seretide/Advair sales growth increased 1% primarily reflecting favourable US pricing. However this was offset by generic erosion impacts in Europe and certain International markets. In the US, growth was impacted by unfavourable RAR adjustments and the impact of US of channel inventory reduction ahead of 2024 price changes. Other general medicines 2023 £m 2022 £m Growth £% Growth CER% Other general medicines 3,395 3,570 (5) 2 Decline of 5% at AER reflects adverse currency impacts. Low single digit growth of 2% reflected ongoing post pandemic demand for anti-infectives in Europe and International, and certain third party manufacturing arrangements. Overall growth in this product group continues to be impacted by ongoing generic competition. 88 9.710.110.2202120222023 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 International Total Excluding COVID 2023 £m 7,944 7,893 2022 £m Growth £% Growth CER% 8,434 7,402 (6) 7 1 15 COVID-19 solutions impacted growth by 14 percentage points. Excluding the impact of COVID-19 solutions, International continued to grow by 7% AER, 15% CER, with strong growth across all product groups. Vaccines double digit growth was driven by Shingrix launch uptake across several markets, strong momentum and channel inventory build in China, and a new public programme in Australia. Established and Meningitis vaccines also contributed to the growth. Specialty Medicines grew in HIV, Nucala, Benlysta and Zejula. General Medicines growth was driven by Trelegy and growth across Established Respiratory. Other General Medicines growth was driven by Augmentin on strong post pandemic antibiotic demand. Group financial review continued Financial performance continued Turnover by regions US Total Excluding COVID 2023 £m 2022 £m Growth £% Growth CER% 15,820 14,542 15,810 13,714 9 15 9 16 Sales growth was adversely impacted by 7 percentage points due to decreased sales of Xevudy. Vaccines grew strongly driven by Arexvy launch uptake and leading market share, partly offset by competition and lower market demand for Influenza vaccines. Growth benefitted from favourable US CDC stockpile movements by 4 percentage points. Specialty Medicines grew driven by a strong HIV performance, Benlysta and Nucala continued growth, and strong Oncology growth despite partial offset from the impact of the withdrawal of Blenrep in November 2022. General Medicines growth was largely driven by Trelegy from increased patient demand and growth of the SITT market, partially offset by Established Respiratory and Other General Medicines. Europe Total Excluding COVID 2023 £m 6,564 6,431 2022 £m Growth £% Growth CER% 6,348 5,835 3 10 2 8 COVID-19 solutions impacted growth by 6 percentage points. Excluding the impact of COVID-19 solutions, Europe delivered strong growth of 10% AER, 8% CER. Vaccines growth reflected Shingrix national immunisation programme initiation in the UK and launch uptake across several markets, together with Bexsero national immunisation campaigns in France and Spain, and ongoing travel vaccine recovery. Specialty Medicines double digit growth was driven by growth in HIV, Oncology, Benlysta and Nucala including the impact of new indication launches. General Medicines low single digit growth was maintained. 89 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Cost of sales 2023 £m 2022 £m Growth £% Growth CER% Total cost of sales (8,565) (9,554) % of sales 28.2% 32.6% Adjusted cost of sales (7,716) (8,741) % of sales 25.4% 29.8% (10) (4.3) (12) (4.4) (10) (4.6) (11) (4.6) Total and Adjusted cost of sales as a percentage of sales decreased primarily reflecting lower sales of lower margin Xevudy compared to 2022. Excluding Xevudy, the year benefitted from an increasing margin contribution from Vaccines sales, particularly the launch of Arexvy in Q3 2023 in the US and Shingrix outside the US. In addition, Specialty Medicines, particularly HIV, contributed to the improved margin, as well as continued operational efficiencies. This was partly offset by adverse inventory provision adjustments in the year as well as inflationary impact on input costs. In the late stage, increased investment in Vaccines was driven by continued acceleration and progression of the pipeline including RSV, pneumococcal, mRNA and therapeutic HSV vaccines. Respiratory/Immunology investment continued in depemokimab in the Phase III programmes in asthma and nasal polyps together with camlipixant a new asset for refractory chronic cough, Nucala in COPD, paediatric Benlysta and CCL 17 in osteo arthritic pain. This was offset by decreased expense in the completion of the clinical programme for otilimab. Infectious Diseases investment in bepirovirsen for treatment of chronic hepatitis B increased to support both monotherapy and combination programmes. Investment in key assets in oncology continued such as Jemperli and Ojjaara but were offset by reduction in the terminated Cell and Gene Therapy programme. In the early-stages, investment increased in IL18 for atopic dermatitis, and in the HIV portfolio, focused on next generation long-acting treatments and preventative medicines. Selling, general and administration 2022 £m 2023 £m Growth £% Growth CER% Total R&D included higher impairment charges compared with 2022. Total selling, general and administration % of sales Adjusted selling, general and administration % of sales (9,385) (8,372) 30.9% 28.6% (9,029) (8,128) 29.8% 27.7% 12 2.4 11 2.1 14 2.3 13 1.9 Royalty income Total royalty income Adjusted royalty income 2023 £m 953 953 2022 £m 758 758 Growth £% Growth CER% 26 26 26 26 Growth in Total and Adjusted SG&A in 2023 primarily reflected increased investment for growth in Vaccines, including disease awareness, launch and global market expansion for Arexvy, and investment behind global market expansion and disease awareness for Shingrix. In Specialty Medicines, increased investment was targeted behind long-acting injectables in HIV and the launch of Ojjaara for myelofibrosis in Oncology. This was partly offset by the continuing benefit of restructuring and tight control of ongoing costs. 2023 also reflected the Zejula royalty dispute in Q1 2023. Total SG&A also included an increase in significant legal costs (see details on page 96). Research and development Total research and development % of sales Adjusted research and development % of sales 2023 £m 2022 £m Growth £% Growth CER% (6,223) (5,488) 20.5% 18.7% (5,750) (5,062) 19.0% 17.3% 13 1.8 14 1.7 14 1.5 14 1.4 Growth in Total and Adjusted royalty income primarily related to Gardasil royalties, which were £472 million in 2023, as well as Kesimpta and Biktarvy royalties. The overwhelming majority of the income from Gardasil royalties ceased at the end of 2023. Other operating income/(expense) 2022 £m 2023 £m Growth £% Growth CER% Other operating income/ (expenses) (363) (235) (54) (54) Other operating expenses reflected a charge of £546 million (2022: £1,726 million) arising from the remeasurement of contingent consideration liabilities and the liabilities for the Pfizer put option, and a fair value loss of £17 million (2022: £229 million gain) on the retained stake in Haleon plc, partly offset by £200 million (2022: £306 million) of other net income primarily related to equity investments and milestone income (including £49 million dividends received from the retained investment in Haleon plc). In Q1 2022 upfront income of £0.9 billion was received from the settlement with Gilead Sciences Inc. R&D operating expense growth in 2023 was driven by investment across the portfolio. 90 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Operating profit Total operating profit % of sales Adjusted operating profit 2023 £m 6,745 22.2% 8,786 2022 £m 6,433 21.9% 8,151 % of sales 29.0% 27.8% Growth £% Growth CER% 5 0.3 8 1.2 10 1.0 12 1.8 Total operating profit margin was higher in 2023 due to profitable growth across the portfolio as well as favourable movements in contingent consideration liabilities, partly offset by an unfavourable comparison due to the £0.9 billion upfront income received from the settlement with Gilead Sciences Inc. in Q1 2022. Adjusted operating profit benefitted from strong sales, favourable product mix and increased royalty income partly offset by increased investment behind product launches and in R&D. It also included increased legal charges primarily relating to the Zejula royalty dispute. In 2023 the adverse impact of lower sales of COVID-19 solutions was 5 percentage points of Total operating profit growth at AER (6 percentage points at CER), with an impact in Total operating profit margin of 0.5 percentage points. In 2023 the adverse impact of lower sales of COVID-19 solutions was 4 percentage points of Adjusted operating profit growth, with an impact in Adjusted operating profit margin of 0.4 percentage points. Adjusted operating profit by business Commercial operations % of sales R&D 2023 £m 2022 £m Growth £% Growth CER% 14,656 13,590 48.3% 46.3% (5,607) (5,060) 8 2.0 11 10 2.1 11 Commercial Operations Adjusted operating profit benefitted from strong sales and favourable product mix (with minimal Xevudy sales) and increased royalty income, partly offset by increased investment in growth and launch assets as well as an increase in legal provisions in 2023. The R&D segment operating expenses growth was driven by progression of the late stage in Vaccines, Respiratory/ Immunology and Infectious Diseases. This included pneumococcal and mRNA programmes together with the newly acquired camlipixant and ongoing investment in key programmes such as depemokimab and bepirovirsen. Net finance costs Total net finance cost Adjusted finance cost 2023 £m 677 669 2022 £m 803 791 Growth £% Growth CER% (16) (15) (15) (15) Total net finance costs were £677 million compared with £803 million in 2022. Adjusted net finance costs were £669 million compared with £791 million in 2022. The decrease was mainly driven by the net savings from maturing bonds including the Sterling Notes repurchase in Q4 2022 and higher interest income on cash, partly offset by higher interest on short-term financing. Share of after tax profits of associates and joint ventures The share of after tax loss of associates and joint ventures was £5 million (2022: £2 million share of loss). Profit on disposal of interest in associates In 2023, the Group also reported a profit on disposal of interests in associates and joint ventures of £1 million. Profit before tax Taking account of net finance costs, the share of profits or losses of associates and profit or loss on disposal of interest in associates, profit before taxation was £6,064 million compared with £5,628 million in 2022. Taxation UK current year charge Rest of world current year charge Charge/(credit) in respect of prior periods Total current taxation Total deferred taxation Taxation on total profits 2023 £m 207 1,371 43 1,621 2022 £m 200 1,351 (60) 1,491 (865) (784) 756 707 The charge of £756 million represented an effective tax rate on Total results of 12.5% (2022: 12.6%) and reflected the different tax effects of the various Adjusting items. Tax on Adjusted profit amounted to £1,257 million and represented an effective Adjusted tax rate of 15.5% (2022: 15.5%). Issues related to taxation are described in Note 14, 'Taxation' to the financial statements. The Group continues to believe it has made adequate provision for the liabilities likely to arise from periods which are open and not yet agreed by tax authorities. The ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of agreements with relevant tax authorities. Non-controlling interests (NCI) Total continuing Adjusted 2023 £m 380 572 2022 £m 460 595 Growth £% Growth CER% (17) (4) (17) (4) The decrease in Total profit from continuing operations allocated to NCIs was primarily driven by lower ViiV Healthcare profits with an allocation of £374 million (2022: £416 million), as well as lower net profits in some of the Group's other entities. The decrease in Adjusted profit from continuing operations allocated to NCIs reflected lower net profits in some of the Group's other entities with NCIs, partly offset by higher profits in ViiV Healthcare with an allocation of £566 million (2022: £551 million). 91 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Earnings per share from continuing operations 2023 £m 2022 £p Growth £% Growth CER% Total continuing earnings per share 121.6p 110.8p Adjusted earnings per share 155.1p 139.7p 10 11 16 16 In 2023, the increase in Total continuing EPS primarily reflected lower charges related to the remeasurement of contingent consideration liabilities, partly offset by a fair value loss on the retained stake in Haleon plc compared to a fair value gain in the same period last year. In addition, there is an unfavourable comparison due to upfront income received from the settlement with Gilead Sciences Inc. in Q1 2022. Adjusted EPS reflected the growth in Adjusted Operating profit as well as lower finance costs. Growth also reflected a favourable benefit from lower non-controlling interests. Lower sales from lower margin COVID-19 solutions reduced Adjusted EPS by six percentage points. Currency impact on results 2023 £m/£p 2022 £m/£p Growth £% Growth CER% Turnover 30,328 29,324 Total continuing earnings per share 121.6p 110.8p Adjusted earnings per share 155.1p 139.7p 3 10 11 5 16 16 The adverse currency impact primarily reflected weakening of emerging market currencies and the Yen against Sterling and strengthening of Sterling against the US Dollar, partly offset by weakening of Sterling against the Euro. Exchange gains or losses on the settlement of intercompany transactions had a minimal impact on Adjusted EPS. Dividends The Board has declared four interim dividends resulting in a total dividend for the year of 58.00p per share. The 2022 dividend per share was 61.25p retrospectively adjusted for the share consolidation. The GSK group dividend in 2022 was 55.00p per share, this is GSK related only and excludes the dividend related to Consumer Healthcare in H1 2022. Please refer to Note 16, 'Dividends' to the financial statements. Dividend policy Dividends remain an essential component of total shareholder return and GSK recognises the importance of dividends to shareholders. On 23 June 2021, at the GSK Investor Update, GSK set out that from 2022 a progressive dividend policy will be implemented guided by a 40 to 60 percent pay-out ratio through the investment cycle. Consistent with this, and reflecting strong business performance during the year, GSK declared an increased dividend of 16.00p for Q4 2023 and 58.00p per share for full year 2023. The expected dividend for 2024 is 60.00p. In setting its dividend policy, GSK considers the capital allocation priorities of the Group and its investment strategy for growth alongside the sustainability of the dividend. 92 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Intangible asset amortisation £m Intangible asset impairment £m Major restructuring £m Transaction- related £m Divestments, significant legal and other items £m Adjusted results £m 30,328 (7,716) 22,612 (9,029) (5,750) 953 – 8,786 13 13 13 25 25 127 1 546 572 (183) (30) 647 647 72 398 719 398 164 164 216 2 382 1 Group financial review continued Adjusting items Adjusted results reconciliation 31 December 2023 Turnover Cost of sales Gross profit Selling, general and administration Research and development Royalty income Other operating (expense)/income Operating profit Net finance costs Share of after-tax losses of associates and joint ventures Profit/(loss) on disposal of interest in associates Total results £m 30,328 (8,565) 21,763 (9,385) (6,223) 953 (363) 6,745 (677) (5) 1 Taxation Tax rate Profit after taxation from continuing operations Profit attributable to non-controlling interests from continuing operations Profit attributable to shareholders from continuing operations Earnings per share from continuing operations Weighted average number of shares (millions) 12.5% 5,308 380 4,928 5,308 121.6p 4,052 Profit before taxation 6,064 719 398 383 572 (756) (154) (94) (83) (100) (70) (1,257) 565 304 300 472 (94) 565 565 13.9p 304 304 7.5p 300 300 7.4p 192 280 472 6.9p 7 (669) (5) – 8,112 (1) (24) 15.5% 6,855 572 (94) 6,283 (94) 6,855 (2.2) p 155.1p 4,052 93 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Adjusted results reconciliation 31 December 2022 Turnover Cost of sales Gross profit Selling, general and administration Research and development Royalty income Other operating (expense)/income Operating profit Net finance costs Share of after-tax profits of associates and joint ventures Profit before taxation Taxation Total results £m 29,324 (9,554) 19,770 (8,372) (5,488) 758 (235) 6,433 (803) (2) 5,628 (707) Tax rate Profit after taxation from continuing operations 12.6% 4,921 Profit after taxation from discontinued operations and other gains/(losses) from the demerger Remeasurement of discontinued operations distributed to shareholders on demerger Profit after taxation from discontinued operations Total profit after taxation for the year Profit attributable to non-controlling interests from continuing operations Profit attributable to shareholders from continuing operations Profit attributable to non-controlling interest from discontinued operations Profit attributable to shareholders from discontinued operations Total profit attributable to non-controlling interests Total profit attributable to shareholders 3,049 (3,049) 7,651 (7,651) 10,700 15,621 (10,700) (10,700) 460 4,461 205 (205) 10,495 15,621 (10,495) (10,700) 665 (205) 14,956 15,621 (10,495) (10,700) Earnings per share from continuing operations 110.8p Earnings per share from discontinued operations 260.6p (260.6) p Profit from discontinued operations £m Intangible asset amortisation £m Intangible asset impairment £m Major restructuring £m Transaction- related £m Divestments, significant legal and other items £m 648 648 91 296 739 296 102 102 180 39 321 2 45 45 13 18 18 51 1,692 1,750 (1,457) (1,388) 10 Adjusted results £m 29,324 (8,741) 20,583 (8,128) (5,062) 758 8,151 (791) (2) 739 296 323 1,750 (1,378) 7,358 (150) (64) (87) (242) 112 589 232 236 1,508 (1,266) (1,138) 15.5% 6,220 589 232 236 1,508 (1,266) 6,220 135 595 589 232 236 1,373 (1,266) 5,625 589 232 236 1,508 (1,266) 6,220 589 589 14.6p 232 232 5.8p 236 236 5.9p 135 1,373 1,508 34.1p 595 5,625 6,220 (1,266) (1,266) (31.5) p 139.7p Total earnings per share 371.4p (260.6) p 14.6p 5.8p 5.9p 34.1p (31.5) p 139.7p Weighted average number of shares (millions) 4,026 4,026 94 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Adjusted results reconciliation 31 December 2021 Turnover Cost of sales Gross profit Selling, general and administration Research and development Royalty income Other operating (expense)/income Operating profit Net finance costs Loss on disposal of interest in associates Share of after-tax profits of associates and joint ventures Profit before taxation Taxation Tax rate Total results £m 24,696 (8,163) 16,533 (7,070) (5,019) 417 (504) 4,357 (755) (36) 33 3,599 (83) 2.3 % Profit from discontinued operations £m Intangible asset amortisation £m Intangible asset impairment £m Major restructuring £m Transaction- related £m Divestments, significant legal and other items £m 660 660 101 347 761 347 28 28 9 1,106 1,143 102 102 277 45 424 2 27 27 35 1 (602) (539) 1 36 761 (153) 347 (81) 426 (79) 1,143 (179) (502) (343) Profit after taxation from continuing operations 3,516 608 266 347 964 (845) Adjusted results £m 24,696 (7,346) 17,350 (6,749) (4,525) 417 6,493 (752) 33 5,774 (918) 15.9 % 4,856 Profit after taxation from discontinued operations and other gains/(losses) from the demerger Profit after taxation from discontinued operations Total profit after taxation for the year Profit attributable to non-controlling interests from continuing operations Profit attributable to shareholders from continuing operations Profit attributable to non-controlling interest from discontinued operations Profit attributable to shareholders from discontinued operations Total profit attributable to non-controlling interests Total profit attributable to shareholders 1,580 (1,580) 1,580 5,096 (1,580) (1,580) 200 3,316 511 (511) 1,069 5,096 (1,069) (1,580) 711 (511) 608 266 347 964 (845) 4,856 241 441 608 266 347 723 (845) 4,415 608 266 347 964 (845) 4,856 4,385 5,096 (1,069) (1,580) 608 608 266 266 347 347 241 723 964 441 4,415 4,856 (845) (845) Earnings per share from continuing operations 82.9p 15.2p 6.6p 8.7p 18.1p (21.2) p 110.3p Earnings per share from discontinued operations 26.7p (26.7) p Total earnings per share 109.6p (26.7) p 15.2p 6.6p 8.7p 18.1p (21.2) p 110.3p Weighted average number of shares (millions) 4,003 4,003 95 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial performance continued Intangible asset amortisation Transaction-related adjustments See page 210 for description and information on Intangible asset amortisation. Intangible asset impairment See page 210 for description and information on Intangible asset impairment. No individual intangible asset accounted for a material impairment. Major restructuring and integration Within the Pharmaceuticals sector, the highly regulated manufacturing operations and supply chains and long life cycle of the business mean that restructuring programmes, particularly those that involve the rationalisation or closure of manufacturing or R&D sites are likely to take several years to complete. Major restructuring costs are those related to specific Board- approved Major restructuring programmes and are excluded from Adjusted results. Major restructuring programmes, including integration costs following material acquisitions, are those that are structural and are of a significant scale where the costs of individual or related projects exceed £25 million. Other ordinary course smaller-scale restructuring costs are retained within Total and Adjusted results. Total Major restructuring charges incurred in 2023 were £382 million (2022: £321 million), analysed as follows: 2023 Cash £m Non- cash £m Total £m Cash £m Non- cash £m 2022 Total £m 199 117 316 177 110 287 Separation preparation restructuring programme Significant acquisitions Legacy programmes Transaction-related adjustments from continuing operations resulted in a net charge of £572 million (2022: £1,750 million), the majority of which related to charges/(credits) for the remeasurement of contingent consideration liabilities, the liabilities for the Pfizer put option, and Pfizer and Shionogi preferential dividends in ViiV Healthcare. Charge/(credit) Contingent consideration on former Shionogi-ViiV Healthcare Joint Venture (including Shionogi preferential dividends) ViiV Healthcare put options and Pfizer preferential dividends Contingent consideration on former Novartis Vaccines business Contingent consideration on acquisition of Affinivax Other adjustments Total transaction-related charges 2023 £m 2022 £m 934 1,431 (245) 85 (187) 193 44 26 572 17 24 1,750 The £934 million charge relating to the contingent consideration for the former Shionogi-ViiV Healthcare joint venture represented an increase in the valuation of the contingent consideration due to Shionogi, driven by £534 million from updated future sales forecasts and exchange rates, and the unwind of the discount for £400 million. The £245 million credit relating to the ViiV Healthcare put option and Pfizer preferential dividends represented a reduction in the valuation of the put option as a result of updated exchange rates, sales forecasts and cash balances. The ViiV Healthcare contingent consideration liability is fair valued under IFRS. An explanation of the accounting for the non- controlling interests in ViiV Healthcare is set out on page 84. 65 (1) 1 1 66 – 20 9 – 5 20 14 263 119 382 206 115 321 The £187 million credit relating to the contingent consideration on the former Novartis Vaccines business primarily relates to changes to future sales forecasts. The Separation Preparation programme incurred cash charges of £199 million primarily from the restructuring of some commercial and administrative functions as well as Global Supply Chain. The non-cash charges of £117 million primarily reflected the write-down of assets in administrative and manufacturing locations. The benefit in the year 2023 from restructuring programmes was £0.2 billion, primarily relating to the Separation Preparation restructuring programme. The programme is now largely complete and has delivered its target of £1.1 billion of annual savings, with total costs still expected at £2.4 billion, with slightly higher cash charges of £1.7 billion but lower non-cash charges of £0.7 billion. Costs of significant acquisitions relate to integration costs of Sierra Oncology Inc (Sierra) and Affinivax Inc. (Affinivax) which were acquired in Q3 2022 and BELLUS Health Inc. acquired in Q2 2023. The £44 million charge relating to the contingent consideration on the acquisition of Affinivax primarily relates to the unwind of the discount.. Divestments, significant legal charges and other items Divestments, significant legal charges, and other items primarily included £200 million of net income from dividends and milestones related to investments, including £49 million of dividends received from the retained investment in Haleon plc, partly offset by £17 million fair value losses on the investment in Haleon plc. Legal charges provide for all significant legal matters, including Zantac, and are not broken out separately by litigation or investigation. Significant legal charges in the year primarily reflected increased legal charges for Zantac of which the vast majority relate to the prospective legal costs for the defence of the litigation. 96 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Cash generation and conversion A summary of the consolidated cash flow statement is set out below. Total net cash inflow from operating activities Total net cash (outflow) from investing activities 2023 £m 6,768 2022 £m 7,403 (1,595) (8,772) Total net cash inflow/(outflow) from financing activities Decrease in cash and bank overdrafts (5,641) (468) Cash and bank overdrafts at beginning of year 3,425 Exchange adjustments Decrease in cash and bank overdrafts Cash and bank overdrafts at end of year Cash and bank overdrafts at end of year comprise: Cash and cash equivalents Overdrafts 823 (546) 3,819 152 (546) 3,425 (99) (468) 2,858 2,936 (78) 2,858 3,723 (298) 3,425 Reconciliation of net cash inflow from continuing operating activities to free cash inflow A reconciliation of net cash inflow from operating activities, which is the closest equivalent IFRS measure to free cash flow, is shown below. Net cash inflow from continuing operating activities 2023 £m 2022 £m 6,768 6,634 Purchase of property, plant and equipment (1,314) (1,143) Purchase of intangible assets (1,030) (1,115) Proceeds from sale of property, plant and equipment Proceeds from sale of intangible assets Net finance costs Dividends and disposal proceeds from joint ventures and associates Contingent consideration paid (reported in investing activities) 28 12 146 196 (651) (784) 12 6 (11) (79) Contribution from non-controlling interests 7 8 Distributions to non-controlling interests (412) (521) Free cash inflow 3,409 3,348 Capital expenditure and financial investment Cash payments for tangible and intangible fixed assets amounted to £2,344 million (2022: £2,258 million) and disposals realised £40 million (2022: £342 million). Cash payments to acquire equity investments amounted to £123 million (2022: £143 million) and sales of equity investments realised £1,832 million (2022: £238 million). Free cash flow Free cash flow is the amount of cash generated by the Group after meeting our obligations for contingent consideration, interest, tax and dividends paid to non-controlling interests, and after capital expenditure on property, plant and equipment and intangible assets. Free cash inflow 2023 £m 3,409 2022 £m 3,348 Total cash payments to Shionogi in relation to the ViiV Healthcare contingent consideration liability in the year were £1,106 million (2022: £1,100 million), all of which was recognised in cash flows from operating activities. These payments are deductible for tax purposes. Future cash flow Over the long term, we expect that future cash generated from operations will be sufficient to fund our operating and debt servicing costs, normal levels of capital expenditure, obligations under existing licensing agreements, expenditure arising from restructuring programmes and other routine outflows including tax, pension contributions and dividends, subject to the ‘Principal risks and uncertainties’ discussed on pages 284 to 294. We may from time to time have additional demands for finance, such as for acquisitions. We have access to multiple sources of liquidity from short and long-term capital markets and financial institutions for such needs, in addition to the cash flow from operations. 97 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial position and resources Assets Non-current assets Property, plant and equipment Right of use assets Goodwill Other intangible assets Investments in associates and joint ventures Other investments Deferred tax assets Other non-current assets Total non-current assets Current assets Inventories Current tax recoverable Trade and other receivables Derivative financial instruments Current equity investments Liquid investments Cash and cash equivalents Assets held for sale Total current assets Total assets Liabilities Current liabilities Short-term borrowings Contingent consideration liabilities Trade and other payables Derivative financial instruments Current tax payable Short-term provisions Total current liabilities Non-current liabilities Long-term borrowings Corporation tax payable Deferred tax liabilities 2023 £m 2022 £m 9,020 937 6,811 14,768 55 1,137 6,049 1,584 8,933 687 7,046 14,318 74 1,467 5,658 1,194 40,361 39,377 5,498 373 7,385 130 2,204 42 2,936 76 5,146 405 7,053 190 4,087 67 3,723 98 18,644 59,005 20,769 60,146 (2,813) (3,952) (1,053) (1,289) (15,844) (16,263) (114) (500) (744) (183) (471) (652) (21,068) (22,810) (15,205) (17,035) (75) (311) (127) (289) Pensions and other post-employment benefits (2,340) (2,579) Other provisions Contingent consideration liabilities Other non-current liabilities Total non-current liabilities Total liabilities Net assets Total equity (495) (532) (5,609) (5,779) (1,107) (899) (25,142) (27,240) (46,210) (50,050) 12,795 10,096 12,795 10,096 Property, plant and equipment Our business is science-based, technology-intensive and highly regulated by governmental authorities. We allocate significant financial resources to the renewal and maintenance of our property, plant, equipment and vehicles to minimise risks of interruption to production and to ensure compliance with regulatory standards. A number of our processes use hazardous materials. The total cost of our property, plant and equipment at 31 December 2023 was £19,279 million, with a net book value of £9,020 million. Of this, land and buildings represented £2,895 million, plant, equipment and vehicles £4,033 million and assets in construction £2,092 million. In 2023, we invested £1,295 million in new property, plant and equipment. This was mainly related to a large number of projects for the renewal, improvement and expansion of facilities at various worldwide sites to support new product development and launches as well as to improve the efficiency of existing supply chains. Property is mainly held freehold. New investment is financed from our liquid resources. At 31 December 2023, we had contractual commitments for future capital expenditure of £762 million. We believe that our property and plant facilities are adequate for our current requirements. Right of use assets Right of use assets amounted to £937 million at 31 December 2023 compared with £687 million at 31 December 2022. The increase in the year reflected the impact of additions through business combinations of £1 million and other additions of £499 million partly offset by depreciation of £190 million, disposals and impairments amounting to £30 million. Goodwill Goodwill decreased to £6,811 million at 31 December 2023, from £7,046 million primarily as a result of an exchange rate loss of £313 million, partially offset by an increase of £109 million from acquisitions-related transactions. Other intangible assets Other intangible assets include the cost of intangibles acquired from third parties and computer software. The net book value of other intangible assets as at 31 December 2023 was £14,768 million (2022: £14,318 million). The increase primarily reflected additions, net of disposals and write-offs of £2,476 million partly offset by impairment losses, net of reversals and amortisation of £1,630 million and exchange rate losses of £431 million. 98 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial position and resources continued Investments in associates and joint ventures We held investments in associates and joint ventures with a carrying value at 31 December 2023 of £55 million (2022: £74 million). See Note 21, 'Investments in associates and joint ventures' to the financial statements, for more details. Current equity investments Current equity investments amounted to £2,204 million at 31 December 2023 (2022: £4,087 million). Current equity investments comprise equity investments which the Group holds with the intention to sell and which it may sell in the short term. Where acquired with this intention, they are measured at fair value through the profit and loss (FVTPL). They are initially recorded at fair value plus transaction costs and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in the income statement. The investment of £2,204 million (2022: £4,087 million) represents the shares held in Haleon plc after the demerger. During 2023, disposals of Haleon plc shares resulted in gross proceeds of £1,863 million (2022: £nil). Other investments At 31 December 2023 we held other investments with a carrying value of £1,137 million (2022: £1,467 million). The most significant of these investments held at 31 December 2023 were in Crispr Therapeutics AG, Vir Biotechnology Inc. and SR One Capital Fund I-B, LP. These investments had a fair value at 31 December 2023 of £158 million (2022: £109 million), £67 million (2022: £180 million) and £102 million (2022: £211 million) respectively. The other investments included equity stakes in companies with which we have research collaborations, and which provide access to biotechnology developments of potential interest and interests in companies that arise from business divestments. Derivative financial instruments: assets We held current derivative financial assets at fair value of £130 million (2022: £190 million). The majority of these financial instruments related to foreign exchange contracts both designated and not designated as accounting hedges. Inventories Inventories amounted to £5,498 million (2022: £5,146 million) at 31 December 2023. Trade and other receivables Trade and other receivables amounted to £7,385 million (2022: £7,053 million) at 31 December 2023. The increase is mainly driven by Arexvy sales in the US. Deferred tax assets Deferred tax assets amounted to £6,049 million (2022: £5,658 million) at 31 December 2023. Derivative financial instruments: liabilities We held current derivative financial liabilities at fair value of £114 million (2022: £183 million). This is primarily related to foreign exchange contracts both designated and not designated as accounting hedges. Trade and other payables At 31 December 2023, trade and other payables were £15,844 million compared with £16,263 million at 31 December 2022. The decrease was primarily driven by lower accruals relating to profit share collaborations partly offset by higher customer return and rebates accruals. See Note 29, 'Trade and other payables' to the financial statements. Provisions We carried deferred tax provisions and other short-term and non-current provisions of £1,550 million at 31 December 2023 (2022: £1,473 million). Other provisions at the year-end included £267 million (2022: £218 million) related to legal and other disputes and £282 million (2022: £351 million) related to Major restructuring programmes. Provision has been made for legal and other disputes, indemnified disposal liabilities, employee related liabilities and the costs of the restructuring programme to the extent that at the balance sheet date a legal or constructive obligation existed and could be reliably estimated. Pensions and other post-employment benefits We account for pension and other post-employment arrangements in accordance with IAS 19. The net deficits were £763 million (2022: £1,356 million) on pension arrangements and £943 million (2022: £994 million) on unfunded post- employment liabilities. See Note 31, 'Pensions and other post- employment benefits' to the financial statements. Other non-current liabilities Other non-current liabilities amounted to £1,107 million at 31 December 2023 (2022: £899 million). Contingent consideration liabilities Contingent consideration amounted to £6,662 million at 31 December 2023 (2022: £7,068 million), of which £5,718 million (2022: £5,890 million) represented the estimated present value of amounts payable to Shionogi relating to ViiV Healthcare, £516 million (2022: £501 million) represented the estimated present value of contingent consideration payable to the former shareholders of Affinivax and £424 million (2022: £673 million) represented the estimated present value of contingent consideration payable to Novartis related to the Vaccines acquisition. The liability due to Shionogi was £267 million in respect of preferential dividends. An explanation of the accounting for the non-controlling interests in ViiV Healthcare is set out on page 84. Of the total contingent consideration payable (on a post-tax basis) at 31 December 2023, £1,017 million (2022: £940 million) is expected to be paid within one year to Shionogi. The consideration payable is expected to be paid over a number of years. As a result, the total estimated liabilities are discounted to their present values, on a post-tax basis using post-tax discount rates. The Shionogi-ViiV Healthcare contingent consideration liability is discounted at 8%, the Affinivax contingent consideration liability is discounted at 8.5%, and the Novartis Vaccines contingent consideration liability is discounted partly at 7.5% and partly at 8.5%. 99 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial position and resources continued Maturity profile of bond debt £m equivalent Net debt Liquid investments Cash and cash equivalents Short term borrowings Long term borrowings Cash and liquid investments of £2.2 billion (2022: £3.1 billion) were held centrally at 31 December 2023. The analysis of cash and gross debt after the effects of hedging is as follows: 2023 £m 42 2022 £m 67 2,936 3,723 (2,813) (3,952) Net debt the end of the year (15,040) (17,197) Cash and cash equivalents (15,205) (17,035) Liquid investments At 31 December 2023, net debt was £15.0 billion, compared with £17.2 billion at 31 December 2022, comprising gross debt of £18.0 billion and cash and liquid investments of £3.0 billion. Net debt decreased by £2.2 billion primarily due to £3.4 billion free cash inflow, £1.9 billion proceeds from the disposal of investments, including the partial sale of the retained stake in Haleon plc, and net favourable exchange impacts of £0.6 billion from the translation of non-sterling denominated debt. These were partly offset by dividends paid to shareholders of £2.2 billion and the net acquisition cost of BELLUS Health Inc. for £1.5 billion. At 31 December 2023, GSK had short-term borrowings (including overdrafts and lease liabilities) repayable within 12 months of £2.8 billion and £1.6 billion repayable in the subsequent year. At 31 December 2023, GSK’s cash and liquid investments were held as follows: Bank balances and deposits US Treasury and Treasury repo only money market funds Liquidity funds Cash and cash equivalents Liquid investments – government securities 2023 £m 1,942 155 839 2,936 42 2022 £m 1,324 146 2,253 3,723 67 2,978 3,790 Gross debt – fixed – floating Net debt Movements in net debt Total net debt at beginning of year Decrease in cash and bank overdrafts Decrease in liquid investments Net decrease/(increase) in long-term loans Net decrease in short-term loans Repayment of lease liabilities Debt of subsidiary undertaking acquired Exchange adjustments Other non-cash movements Decrease/(increase) in net debt from continuing operations Decrease/(increase) in net debt from discontinued operations 2023 £m 42 2022 £m 67 2,936 3,723 (16,898) (19,214) (1,120) (1,773) (15,040) (17,197) 2023 £m 2022 £m (17,197) (19,838) (468) (7,597) (72) (79) 2,449 197 50 554 (474) (1) 569 4,053 202 (24) (1,531) (207) 2,157 (4,536) – 7,177 Total net debt at end of year (15,040) (17,197) 100 USD bondsEUR bondsGBP bondsJPY bonds20242025202620272028202920302031203220332034203520362037203820392040204120422043204420450500100015002000 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Financial position and resources continued Total equity At 31 December 2023, total equity had increased from £10,096 million at 31 December 2022 to £12,795 million. A summary of the movements in equity is set out below: Total equity at beginning of year Total comprehensive income for the year Non-cash distribution to non-controlling interests Deconsolidation of former subsidiaries Dividends to shareholders Ordinary shares issued Changes in non-controlling interests Non-cash dividends to shareholders Hedging gain/loss transferred to non-financial assets Share-based incentive plans Tax on share-based incentive plans Contributions from non-controlling interests Distributions to non-controlling interests Total equity at end of year 2023 £m 10,096 4,991 2022 £m 21,342 14,790 – – (2,960) (3,045) (2,247) (3,467) 10 – – 36 307 7 7 25 (20) (15,526) 9 357 (8) 8 (412) (1,409) 12,795 10,096 Share purchases At 31 December 2023, GSK held 197.1 million shares as Treasury shares (2022: 217.1 million shares), at a cost of £3,447 million (2022: £3,798 million), which has been deducted from retained earnings. No ordinary shares were repurchased in the period 1 January 2023 to 27 February 2024 and the company does not expect to make any ordinary share repurchases in the remainder of 2024. In 2023, 20 million Treasury shares were transferred to the Employee Share Ownership Plan (ESOP) Trusts. Shares are held by the Trusts to satisfy future exercises of options and awards under the Group share option and award schemes. A proportion of the shares held by the Trusts are in respect of awards where the rules of the scheme require GSK to satisfy exercises through market purchases rather than the issue of new shares. The shares held by the Trusts are matched to options and awards granted. At 31 December 2023, the ESOP Trusts held 58.8 million (2022: 59.9 million) GSK shares against the future exercise of share options and share awards and for the Executive Supplemental Savings plan. The carrying value of £288 million (2022: £353 million) has been deducted from other reserves. The market value of these shares was £853 million (2022: £861 million). Contractual obligations and commitments Financial commitments are summarised in Note 36, 'Commitments' to the financial statements. The following table sets out our contractual obligations and commitments at 31 December 2023 as they fall due for payment. Total Under 1 yr 1-3 yrs 3-5 yrs 5 yrs+ £m 16,900 £m 2,660 £m 2,913 £m 3,101 £m 8,226 Loans Interest on loans 5,446 547 973 848 3,078 Finance lease obligations Future finance charges on leases Lease contracts that have not yet commenced 1,207 156 348 202 501 254 41 67 50 96 5 1 2 2 – Intangible assets 16,329 386 835 1,956 13,152 Property, plant & equipment Investments Purchase commitments Total 762 153 587 63 175 73 31 4 9 – 17 3 – – 15 41,087 4,445 5,395 6,179 25,068 Commitments in respect of loans and future interest payable on loans are disclosed before taking into account the effect of derivatives. We have entered into a number of research collaborations to develop new compounds with other pharmaceutical companies. The terms of these arrangements can include upfront fees, equity investments, loans and commitments to fund specified levels of research. In addition, we will often agree to make further payments if future ‘milestones’ are achieved. As some of these agreements relate to compounds in the early stages of development, the potential obligation to make milestone payments will continue for a number of years if the compounds move successfully through the development process. Generally, the closer the product is to marketing approval, the greater the probability of success. The amounts shown above within intangible assets represent the maximum that would be paid if all milestones were achieved. There was an increase in the commitments in 2023 mainly attributable to new R&D collaborations resulting in higher intangible assets commitments. 101 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 In the normal course of business, we have provided various indemnification guarantees in respect of business disposals in which legal and other disputes have subsequently arisen. A provision is made where an outflow of resources is considered probable and a reliable estimate can be made of the likely outcome of the dispute and this is included in Note 32, 'Other provisions' to the financial statements. We provide for the outcome of tax, legal and other disputes when an outflow of resources is considered probable and a reliable estimate of the outflow may be made. At 31 December 2023, other than for those disputes where provision has been made, it was not possible to make a reliable estimate of the potential outflow of funds that might be required to settle disputes where the possibility of there being an outflow was more than remote. The ultimate liability for such matters may vary significantly from the amounts provided and is dependent upon negotiations with the relevant tax authorities and the outcome of litigation proceedings, where relevant. This is discussed further in ‘Principal risks and uncertainties’ on pages 284 to 294 and Note 47, 'Legal proceedings' to the financial statements. Group financial review continued Financial position and resources continued In connection with the demerger of Consumer Healthcare, the 31 December 2020 pension scheme valuations identified cash funding or technical provisions deficits in three GSK UK Pension Schemes. Scottish limited partnerships (“SLPs”) were established to provide a funding mechanism for each of GSK’s UK defined benefit pension schemes. The SLPs together held shares representing 7.5% of the total issued share capital of Haleon plc. Each pension scheme, through its SLP interest, was entitled to receive a distribution from that SLP in an amount equal to the net proceeds of sales of Haleon plc shares, and to receive dividend income on Haleon plc shares, until it had received an aggregate amount equal to an agreed threshold (“Proceeds Threshold”). The Proceeds Thresholds total £1,080 million (as increased by notional interest on the remaining balance from time to time), and payment of this amount would fully fund the cash funding or technical provisions deficits in the three schemes shown by the 31 December 2020 valuations. Once the Proceeds Threshold has been reached, the GSK-controlled General Partner of each SLP is entitled to sell the remaining Haleon plc shares held by the SLP and distribute the proceeds to GSK. As at 31 December 2023, total cash contributions totalling £353 million (2022: £691 million) were made towards the Proceeds Threshold leaving no further outstanding amount due to the UK pension schemes. The cash contributions included £17 million of distributions of dividends on Haleon plc shares from the SLPs to the Schemes. Contingent liabilities Other contingent liabilities are set out in Note 35, 'Contingent liabilities' to the financial statements. The following table sets out contingent liabilities, comprising performance guarantees, letters of credit and other items arising in the normal course of business, and when they are expected to expire. Guarantees Other contingent liabilities Total Total Under 1 yr 1-3 yrs 3-5 yrs 5 yrs+ £m 14 18 32 £m 9 6 15 £m 3 – 3 £m 1 9 10 £m 1 3 4 102 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Approach to tax Business makes a major contribution to the public purse through its tax contribution. This includes direct taxes (such as corporate income tax) and indirect taxes (such as VAT and customs duties) as well as other taxes (such as employment taxes and property taxes). It is therefore important that companies explain their approach to tax. This helps inform dialogue about tax and tax policy. We are supportive of efforts to ensure companies are appropriately transparent about how their tax affairs are managed. As part of that, our Tax Strategy is set out in detail within the Public policies section of our website. We support the exchange of country-by-country reporting (CBCR) data between tax authorities as, validated against existing information held on taxpayers, it will support their ability to ensure multinational groups pay the right amount of tax in the right places. As a global biopharmaceutical company, we have a substantial business and employment presence in many countries around the world and pay a significant amount of tax. This includes corporate income tax and other business taxes, and tax associated with our employees. We also collect a significant amount of tax on behalf of governments along our supply chain, including from our employees. We are subject to taxation throughout our supply chain. The worldwide nature of our operations means that our cross- border supply routes, necessary to ensure supplies of medicines into numerous countries, can result in conflicting claims from tax authorities as to the profits to be taxed in individual countries. This can lead to double taxation (with profits taxed in more than one country). Profits are recognised in territories by reference to the activities performed there and the value they generate. To ensure the profits recognised in jurisdictions are aligned to the activity undertaken there, and in line with current OECD guidelines, we base our transfer pricing policy on the arm’s length principle and support our transfer prices with economic analysis and reports. We do not engage in artificial tax arrangements – those without business or commercial substance. We do not seek to avoid tax by the use of ‘tax havens’ or transactions we would not fully disclose to a tax authority. We have a zero-tolerance approach to tax evasion and the facilitation of tax evasion. Tax risk in all countries in which we operate is managed through robust internal policies, processes, training and compliance programmes. Our Board of Directors and the Audit & Risk Committee are responsible for approving our tax policies and risk management arrangements as part of our wider internal control framework. We seek to maintain open and constructive relationships with tax authorities worldwide, meeting regularly to discuss our tax affairs and real time business updates wherever possible. We also monitor government debate on tax policy in our key jurisdictions so that we can understand and share an informed point of view regarding any potential future changes in tax law, in support of a transparent and sustainable tax system. Where relevant, we provide pragmatic and constructive business input to tax policy makers either directly or through industry trade bodies, advocating reform to support economic growth and job creation as well as the needs of our patients and other key stakeholders. In 2023, the Group corporate tax charge was £756 million (2022: £707 million) on profits before tax of £6,064 million (2022: £5,628 million) representing an effective tax rate of 12.5% (2022: 12.6%). We made cash tax payments of £1,328 million in the year (2022: £1,310 million). In addition to the taxes we pay on our profits, we pay duties, levies, transactional and employment taxes. The Group’s Total tax rate for 2023 of 12.5% (2022: 12.6%) was lower than the Adjusted tax rate reflecting the different tax effects of various Adjusting items. Our Adjusted tax rate for 2023 was 15.5% (2022: 15.5%). The rate has benefited from innovation incentives available in key territories in which we operate, such as the UK and Belgium Patent Box regimes. During 2023 the UK Government enacted legislation introducing a global minimum corporate income tax rate, to have effect from 2024 in line with the Organisation for Economic Co-operation and Development’s (OECD) Pillar Two model framework. We anticipate that the rules will restrict our ability to benefit from innovation incentives and consequentially our effective Adjusted tax rate is forecast to increase to around 17% for 2024. Further details about our corporate tax charges for the year are set out in Note 14 'Taxation' to the financial statements. 103 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Treasury policies We report in Sterling and pay dividends out of Sterling cash flows. The role of Treasury is to monitor and manage the Group’s external and internal funding requirements and financial risks in support of our strategic objectives. GSK operates on a global basis, primarily through subsidiary companies, and we manage our capital to ensure that our subsidiaries are able to operate as going concerns and to optimise returns to shareholders through an appropriate balance of debt and equity. Treasury activities are governed by policies approved annually by the Board of Directors, and most recently on 11 October 2023. A Treasury Management Group (TMG) meeting, chaired by our Chief Financial Officer, takes place on a regular basis to review Treasury activities. Its members receive management information relating to these activities. Treasury operations The objective of GSK’s Treasury activities is to minimise the post-tax net cost of financial operations and reduce its volatility in order to benefit earnings and cash flows. GSK uses a variety of financial instruments to finance its operations and derivative financial instruments to manage market risks from these operations. Derivatives principally comprise foreign exchange forward contracts and swaps which are used to swap borrowings and liquid assets into currencies required for Group purposes, as well as interest rate swaps which are used to manage exposure to financial risks from changes in interest rates. Derivatives are used exclusively for hedging purposes in relation to underlying business activities and not as trading or speculative instruments. Capital management GSK’s financial strategy, implemented through the Group’s financial architecture, supports GSK’s strategic priorities and is regularly reviewed by the Board. We manage the capital structure of the Group through an appropriate mix of debt and equity. We continue to manage our financial policies to a credit profile that particularly targets ratings of at least A2/A (Moody's/S&P), through the cycle. GSK’s long-term credit rating with Standard and Poor’s is A (stable outlook) and with Moody’s Investor Services (‘Moody’s’) is A2 (stable outlook). Our short-term credit ratings are A-1 and P-1 with Standard and Poor’s and Moody’s respectively. Liquidity risk management GSK’s policy is to borrow centrally in order to meet anticipated funding requirements. Our cash flow forecasts and funding requirements are monitored by the TMG on a regular basis. Our strategy is to diversify liquidity sources using a range of facilities and to maintain broad access to financial markets. Each day, we sweep cash to or from a number of global subsidiaries to central treasury accounts for liquidity management purposes. Interest rate risk management GSK’s objective is to minimise the effective net interest cost and to balance the mix of debt at fixed and floating interest rates over time. The policy on interest rate risk management limits the net amount of floating rate debt to a specific cap, reviewed and agreed no less than annually by the Board. Foreign exchange risk management Our objective is to minimise the exposure of overseas operating subsidiaries to transaction risk by matching local currency income with local currency costs where possible. Foreign currency transaction exposures arising on external and internal trade flows are selectively hedged. GSK’s internal trading transactions are matched centrally and we manage inter- company payment terms to reduce foreign currency risk. Where possible, we manage the cash surpluses or borrowing requirements of subsidiary companies centrally using forward contracts to hedge future repayments back into the originating currency. In order to reduce foreign currency translation exposure, we seek to denominate borrowings in the currencies of our principal assets and cash flows. These are primarily denominated in US Dollars, Euros and Sterling. Borrowings can be swapped into other currencies as required. Borrowings denominated in, or swapped into, foreign currencies that match investments in overseas Group assets may be treated as a hedge against the relevant assets. Forward contracts in major currencies are also used to reduce exposure to the Group’s investment in overseas Group assets. The TMG reviews the ratio of borrowings to assets for major currencies regularly. Commodity risk management Our objective is to minimise income statement volatility arising from fluctuations in commodity prices, where practical and cost effective to do so. The TMG is authorised to approve the execution of certain financial derivatives to hedge commodity price exposures. Counterparty risk management We set global counterparty limits for each of our banking and investment counterparties based on long-term credit ratings from Moody’s and Standard and Poor’s. Usage of these limits is actively monitored and any breach of these limits would be reported to the Chief Financial Officer immediately. In addition, relationship banks and their credit ratings are reviewed regularly so that, when changes in ratings occur, changes can be made to investment levels or to authority limits as appropriate. All banking counterparty limits are reviewed at least annually. 104 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Group financial review continued Critical accounting policies The Group consolidated financial statements have been prepared in accordance with UK-adopted international accounting standards in conformity with the requirements of the Companies Act 2006 and the International Financial Reporting Standards (IFRS) as issued by the International Accounting Standard Board (IASB). We are required to make estimates and assumptions that affect the amounts of assets, liabilities, revenue and expenses reported in the financial statements. Actual amounts and results could differ from those estimates. The critical accounting policies relate to the following areas: – Turnover – Taxation (Note 14) – Legal and other disputes (Notes 47) – Contingent liabilities (Note 35) – Pensions and other post-employment benefits (Note 31) Information on the judgements and estimates made in these areas is given in Note 3, 'Critical accounting judgements and key sources of estimation uncertainty' to the financial statements. Turnover In respect of the turnover accounting policy, our largest business is US Commercial Operations, and the US market has the most complex arrangements for rebates, discounts, and allowances. The following briefly describes the nature of the arrangements in existence in our US Commercial Operations: – We have arrangements with certain indirect customers whereby the customer is able to buy products from wholesalers at reduced prices. A chargeback represents the difference between the invoice price to the wholesaler and the indirect customer’s contractual discounted price. Accruals for estimating chargebacks are calculated based on the terms of each agreement, historical experience and product growth rates – Customer rebates are offered to key managed care and Group Purchasing Organisations and other direct and indirect customers. These arrangements require the customer to achieve certain formulary status, performance targets relating to the value of product purchased or pre-determined market shares relative to competitors. The accrual for customer rebates is estimated based on the specific terms in each agreement, historical experience and product growth rates – The US Medicaid programme is a state-administered programme providing assistance to certain poor and vulnerable patients. In 1990, the Medicaid Drug Rebate Program was established to reduce state and federal expenditure on prescription drugs. In 2010, the Patient Protection and Affordable Care Act became law. We participate by providing rebates to states. Accruals for Medicaid rebates are calculated based on the specific terms of the relevant regulations or the Patient Protection and Affordable Care Act – Cash discounts are offered to customers to encourage prompt payment. These are accrued for at the time of invoicing and adjusted subsequently to reflect actual experience – We record an accrual for estimated sales returns by applying historical experience of customer returns to the amounts invoiced, together with market-related information such as stock levels at wholesalers, anticipated price increases and competitor activity A reconciliation of gross turnover to net turnover for US Commercial Operations is as follows: 2023 Margin % £m 2022 Margin % £m 2021 Margin % £m Gross turnover 32,359 100 29,814 100 24,432 100 (8,874) (27) (8,275) (28) (6,875) (28) Market-driven segments Government mandated and state programmes Cash discounts Customer returns Prior year adjustments Other items (6,385) (20) (6,218) (21) (5,134) (566) (344) 591 (961) (2) (536) (2) (438) (1) (255) (1) (253) 2 780 3 855 (3) (768) (2) (673) (21) (2) (1) 4 (3) (51) 49 Total deductions (16,539) (51) (15,272) (51) (12,518) Net turnover 15,820 49 14,542 49 11,914 Market-driven segments consist primarily of managed care and Medicare plans with which we negotiate contract pricing that is honoured via rebates and chargebacks. Mandated segments consist primarily of Medicaid and federal government programmes which receive government-mandated pricing via rebates and chargebacks. 105 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 We may become involved in significant legal proceedings, in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability, if any, that could result from ultimate resolution of the proceedings. In these cases, appropriate disclosure about such cases would be included in the Annual Report, but no provision would be made. This position could change over time and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group’s financial statements. Like many pharmaceutical companies, we are faced with various complex product liability, anti-trust and patent litigation, as well as investigations of our operations conducted by various governmental regulatory agencies. Throughout the year, the General Counsel of the Group, as head of the Group’s legal function, supported by the Senior Vice President and Head of Global Litigation for the Group, who is responsible for all litigation and government investigations, routinely brief the Chief Executive Officer, the Chief Financial Officer and the Board of Directors on the significant litigation pending against the Group and governmental investigations of the Group. These meetings, as appropriate, detail the status of significant litigation and government investigations and review matters such as the number of claims notified to us, information on potential claims not yet notified, assessment of the validity of claims, progress made in settling claims, recent settlement levels and potential reimbursement by insurers. The meetings also include an assessment of whether or not there is sufficient information available for us to be able to make a reliable estimate of the potential outcomes of the disputes. Often, external counsel assisting us with various litigation matters and investigations will also assist in the briefing of the Board and senior management. Following these discussions, for those matters where it is possible to make a reliable estimate of the amount of a provision, if any, that may be required, the level of provision for legal and other disputes is reviewed and adjusted as appropriate. These matters are discussed further in Note 47, 'Legal proceedings' to the financial statements. Group financial review continued Critical accounting policies continued Overall sales deduction as a percentage of sales is consistent year over year with sales growth coming primarily from Trelegy, Arexvy and Specialty Products including HIV. Deductions within the year were split approximately as follows: General Medicines 67%, Specialty Medicines 21% and Vaccines 12%. At 31 December 2023, the total accrual for discounts, rebates, allowances and returns for US Commercial Operations amounted to £5,951 million (2022: £5,855 million). A monthly process is operated to monitor inventory levels at wholesalers for any abnormal movements. This process uses gross sales volumes, prescription volumes based on third party data sources and information received from key wholesalers. The aim of this is to maintain inventories at a consistent level from year to year based on the pattern of consumption. On this basis, US Commercial Operations inventory levels at wholesalers and in other distribution channels at 31 December 2023 were estimated to amount to approximately four weeks of turnover. This calculation uses third party information, the accuracy of which cannot be totally verified, but is believed to be sufficiently reliable for this purpose. Legal and other disputes In respect of the accounting policy for legal and other disputes, the following briefly describes the process by which we determine the level of provision that is necessary. In accordance with the requirements of IAS 37, ‘Provisions, contingent liabilities and contingent assets’, we provide for anticipated settlement costs where an outflow of resources is considered probable and a reliable estimate may be made of the likely outcome of the dispute and legal and other expenses arising from claims against the Group. Strategic report The Strategic report was approved by the Board of Directors on 27 February 2024 Julie Brown Chief Financial Officer 27 February 2024 106 Corporate governance In this section The Board and GSK Leadership Team Chair’s governance statement Corporate governance architecture Ahead Together – Board oversight Continuous engagement and key decisions Board committee reports Remuneration Committee Chair's annual statement Annual report on remuneration Directors’ report 108 114 116 119 121 128 139 142 161 GSK Annual Report 2023 107 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 The Board Sir Jonathan Symonds, CBE Non-Executive Chair Age: 64 Nationality: British Appointed: 1 September 2019 N Dame Emma Walmsley Chief Executive Officer Age: 54 Nationality: British Appointed: 1 January 2017 Chief Executive Officer from 1 April 2017 Julie Brown Chief Financial Officer Age: 61 Nationality: British Appointed: 3 April 2023 Chief Financial Officer from 1 May 2023 Elizabeth (Liz) McKee Anderson Independent Non-Executive Director Age: 66 Nationality: American Appointed: 1 September 2022 A R Skills and experience Jon has extensive international financial, life sciences and governance experience. Jon served as an Independent Non-Executive Director of HSBC Holdings plc from April 2014 and as Chairman of the Group Audit Committee from 1 September 2014 and Deputy Group Chairman from August 2018, until his retirement from the Board in February 2020. He was previously Chairman of HSBC Bank plc, Chief Financial Officer of Novartis AG, Partner and Managing Director of Goldman Sachs, Chief Financial Officer of AstraZeneca plc, and a Partner at KPMG. Jon is a Fellow of the Institute of Chartered Accountants in England and Wales. External appointments Non-Executive Director, Genomics England Limited having previously served as its Chairman; Non-Executive Chair, Energy Aspects; Member, European Round Table for Industry; Senior Advisor to Chatham House. Skills and experience Before being appointed as GSK’s CEO, Emma was the CEO of GSK Consumer Healthcare, a joint venture between GSK and Novartis, from its creation in March 2015. Emma joined GSK in 2010 from L’Oreal, having worked there for 17 years in a variety of roles in Paris, London, New York and Shanghai. Emma was previously a Non-Executive Director of Diageo plc. Emma’s position as an Independent Director of Microsoft, Inc., further supplements the technology and cyber security experience she brings to the Board. Emma holds an MA in Classics and Modern Languages from Oxford University. External appointments Independent Director, Microsoft, Inc. Skills and experience Julie has an extensive financial and life sciences background, having been the Group CFO of Smith & Nephew from 2013 to 2017 and serving as a Non-Executive Director and Audit Chair of Roche Holding AG from 2016 to 2022. Before this, Julie was Interim Group CFO of AstraZeneca plc, having worked in a wide range of commercial, strategic and financial positions across three continents over a 25 year period. Julie was also Chief Operating Officer and CFO and Executive Director of Burberry Group plc from 2017 to 2023, where her responsibilities included Finance, Transformation, Information Technology and oversight of cyber security. Julie is a Fellow of the Institute of Chartered Accountants and the Institute of Tax. External appointments Co-Chair, CFO Leadership Network, Accounting for Sustainability (part of the King Charles III Charitable Fund Group of Companies); Patron, Oxford University Women in Business; Non- Executive Director and Chair of the Audit Committee, Diageo plc (effective 5 August 2024). Skills and experience Liz brings significant experience in commercial biopharmaceuticals and is a seasoned biotech board member. Her significant experience in commercial biopharmaceuticals, both operationally and at Board level, as well as her deep understanding of the biotechnology sector and application of technology, are invaluable to GSK as a pure biopharma company. Before her current roles, Liz served as Worldwide Vice President and commercial leader in infectious diseases and vaccines and also for immunology and oncology at Janssen Pharmaceuticals, and as Vice President and General Manager at Wyeth Vaccines. Liz was also previously a Board member of Huntsworth Plc and a Board Member and Chair of the Science, Technology and Investment Committee of Bavarian Nordic A/S. Liz has a degree in Engineering and Technical Management and an MBA in Finance. External appointments Board Member, BioMarin Pharmaceutical, Inc; Board Member, Revolution Medicines, Inc; Board Member, Insmed, Inc; Trustee, The Wistar Institute; Director, Aro Biotherapeutics Company, a private company. Key Committee Chair C Corporate Responsibility S Science N Nominations & Corporate Governance A Audit & Risk R Remuneration 108 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 The Board continued Charles Bancroft Senior Independent Non-Executive Director Skills and experience Charlie has a wealth of financial and management experience in global biopharma. Age: 64 Nationality: American Appointed: 1 May 2020 Senior Independent Non-Executive Director from 18 July 2022 A N R Dr Hal Barron Non-Executive Director Age: 61 Nationality: American Appointed: 1 January 2018 Chief Scientific Officer and President, R&D from 1 April 2018 Transitioned to the role of Non-Executive Director on 1 August 2022 S Dr Anne Beal Independent Non-Executive Director Age: 61 Nationality: American Appointed: 6 May 2021 C N R Charlie retired from a successful career at Bristol Myers Squibb (BMS) in March 2020 where he held a number of leadership roles in commercial, strategy and finance. Beginning his career at BMS in 1984, he held positions of increasing responsibility within the finance organisation and had commercial operational responsibility for Latin America, Middle East, Africa, Canada, Japan and several Pacific Rim countries. He was appointed Chief Financial Officer in 2010, Chief Financial Officer and Executive Vice President, Global Business Operations in 2016 and Executive Vice President and Head of Integration and Strategy & Business Development in 2019. As Chief Financial Officer, Charlie had line management responsibility for Information Technology, including cyber security. Charlie successfully steered BMS through a period of strategic transformation, including its $74 billion acquisition of Celgene. Charlie also served as a member of the Board of Colgate-Palmolive Company from 2017 until March 2020. External appointments Board Member, Kodiak Sciences Inc; Board Member, BioVector Inc; Advisory Board Member, Drexel University’s LeBow College of Business. The Board determined that Charlie has recent and relevant financial experience and agreed that he has the appropriate qualifications and background to be an audit committee financial expert. Skills and experience Hal has had a distinguished career in biosciences, with a strong track record of research and development (R&D). He joined the Board of GSK in 2018 as Chief Scientific Officer and President, R&D, where he brought a new approach to R&D which focused on science related to the immune system, the use of human genetics and advanced technologies to help identify the next generation of transformational medicines. In August 2022, he transitioned to a Non-Independent Non-Executive Director, with additional responsibilities to support R&D. Before joining GSK, Hal was President, R&D at Calico LLC (California Life Company), an Alphabet-funded company that uses advanced technologies to increase understanding of lifespan biology. Hal was previously Executive Vice President, Head of Global Product Development, and Chief Medical Officer of Roche, responsible for all the products in the combined portfolio of Roche and Genentech. At Genentech, he was Senior Vice President of Development and Chief Medical Officer. Hal was a Non-Executive Director and Chair of the Science & Technology Committee at Juno Therapeutics, Inc until March 2018, when it was acquired by Celgene Corporation. He previously served as a Non-Executive Board Director of GRAIL, Inc and an Advisory Board Member of Verily Life Sciences LLC. External appointments CEO and Board Co-Chair, Altos Labs Inc; Associate Adjunct Professor, Epidemiology & Biostatistics, University of California, San Francisco. Skills and experience Anne brings extensive healthcare experience to the Board as a physician and entrepreneur, and combines this with a passion for patient advocacy. She is a recognised health policy expert in the development of global and national programmes for improving healthcare access for all patient groups and for ensuring the voice of patients is reflected in research programmes. Before her current roles, Anne spent six years at Harvard Medical School and Massachusetts General Hospital, where she was an instructor in paediatrics. She has also held leadership roles at the Commonwealth Fund and the Aetna Foundation. Anne was previously Deputy Executive Director and Chief Engagement Officer for The Patient-Centered Outcomes Research Institute in the US and Chief Patient Officer and Global Head of Patient Solutions at Sanofi. External appointments Founder and CEO, AbsoluteJOI Skincare; Board Member, AcademyHealth; Board Member, Prolacta Bioscience. Key Committee Chair C Corporate Responsibility S Science N Nominations & Corporate Governance A Audit & Risk R Remuneration 109 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 The Board continued Wendy Becker Independent Non-Executive Director Age: 58 Nationality: American Appointed: 1 October 2023 A R Dr Harry (Hal) C Dietz Independent Non-Executive Director and Scientific & Medical Expert Age: 65 Nationality: American Appointed: 1 January 2022 S Skills and experience Wendy is a highly experienced Non-Executive Director and has held significant leadership positions in a wide range of global businesses in public, private and non-profit sectors. She possesses a wealth of strategic and consumer marketing expertise in particular across the technology and life sciences sectors. Wendy has strong executive management experience, having been Chief Executive Officer at Jack Wills Limited, Group Chief Marketing Officer at Vodafone Group plc and Partner at McKinsey & Company. Wendy’s interest in science, healthcare and medical research dates to her time at McKinsey, where she worked with a range of healthcare clients in the US and Europe. This was furthered during the years that she served on the Board of Cancer Research UK. More recently, Wendy spent time as a Non-Executive Director of NHS England and as Chair of the British Heart Foundation. Wendy has held several Non-Executive Director roles, amongst others, as Chair of the Remuneration Committees of Great Portland Estates plc and Ocado Group plc and as a member of the Remuneration and Audit Committees of Whitbread plc. Through her current and prior roles in technology companies, Wendy adds to the Board’s experience in cyber security. External appointments Chair of Logitech International S.A.; Board member and Chair of the Compensation Committee, Sony Group Corporation; Senior Independent Director and Chair of the Remuneration Committee, Oxford Nanopore Technologies plc; Member of the governing bodies of the University of Oxford. Skills and experience Hal brings extensive experience in the field of human genetics which is central to GSK’s approach to R&D. He is a former President of the American Society of Human Genetics and is recognised as the world’s leading authority on the genetic disorder known as Marfan Syndrome. He also brings experience in developing novel therapies, particularly in relation to disease-modifying treatments for fibrotic and neurodegenerative diseases. In total, Hal has authored 282 original publications in peer-reviewed journals during his career. As a physician scientist, he has dedicated his entire career to the care and study of individuals with heritable connective tissue disorders with primary perturbations of extracellular matrix homeostasis and function. His lab has identified the genes for many of these conditions, for which he uses model systems to explain disease mechanisms. Hal has received many prestigious awards including the Curt Stern Award from the American Society of Human Genetics, the Colonel Harland Sanders Lifetime Achievement Award in Medical Genetics, the Taubman Prize for excellence in translational medical science, the Harrington Prize from the American Society for Clinical Investigation and the Harrington Discovery Institute, the Pasarow Award in Cardiovascular Research, the InBev-Baillet Latour Health Prize from Belgium, and the Research Achievement Award from the American Heart Association. He is an inductee of the American Society for Clinical Investigation, the American Association for the Advancement of Science, the Association of American Physicians, the National Academy of Medicine, and the National Academy of Sciences. External appointments Victor A. McKusick Professor of Paediatrics, Medicine, and Molecular Biology & Genetics in the Department of Genetic Medicine, The Johns Hopkins University School of Medicine; Investigator, Howard Hughes Medical Institute; Non-Executive Board Director, Altius Institute for Biomedical Sciences; Independent Chair, GSK’s Human Genetics Scientific Advisory Board. Key Committee Chair C Corporate Responsibility S Science N Nominations & Corporate Governance A Audit & Risk R Remuneration 110 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 The Board continued Dr Jesse Goodman Independent Non-Executive Director and Scientific & Medical Expert Age: 72 Nationality: American Appointed: 1 January 2016 S C Urs Rohner Independent Non-Executive Director Age: 64 Nationality: Swiss Appointed: 1 January 2015 R A N Dr Vishal Sikka Independent Non-Executive Director Age: 56 Nationality: American Appointed: 18 July 2022 C Skills and experience Jesse brings scientific and public health expertise to the Board’s deliberations. He has a wealth of experience spanning science, medicine, vaccines, regulation and public health, and has a proven record in addressing pressing public health needs in both the academic and federal sectors. Jesse previously served in senior leadership positions at the US Food and Drug Administration (FDA), including most recently as the FDA’s Chief Scientist and previously as Deputy Commissioner for Science and Public Health and as Director of the Center for Biologics Evaluation and Research (CBER). Jesse played a leadership role in developing the FDA’s Regulatory Science and Medical Countermeasures Initiatives and has worked collaboratively with industry, academia, government and global public health and regulatory partners to prepare for and respond to major public health threats, including emerging infectious diseases, disasters and terrorism. He led the FDA’s response to West Nile Virus and to the 2009 H1N1 influenza pandemic and served on the Senior Leadership Team for the 2010 White House Medical Countermeasure Review. Jesse was previously a member of both the Scientific Advisory Committee and the Regulatory and Legal Working Group of the Coalition for Epidemic Preparedness Innovations (CEPI). External appointments Professor of Medicine and Attending Physician, Infectious Diseases, Georgetown University and directs the Georgetown University Center on Medical Product Access, Safety and Stewardship (COMPASS); Board Member (formerly President), United States Pharmacopeia (USP); Board Member, Scientific Counselors for Infectious Diseases, Centers for Disease Control and Prevention (CDC); Board Member, Intellia Therapeutics Inc; Member, US National Academy of Medicine; Board Member, Adaptive Phage Therapeutics, Inc. Skills and experience Urs has a broad business, banking and legal background and extensive senior level experience at multinational companies. Urs has served as Chairman on a number of Boards, most recently for Credit Suisse Group from 2011 until April 2021. Before joining Credit Suisse in 2004, Urs served as Chairman of the Executive Board and CEO of ProSieben and ProSiebenSat.1 Media AG. This followed a number of years in private practice at major law firms in Switzerland and the US, having been admitted to the bars of the canton of Zurich in Switzerland in 1986 and the state of New York in the US in 1990. As a founding partner and Chair of Vega Cyber Associates AG, he brings current technology and cybersecurity experience to the Board, further supplemented by digital transformation during his time as Chair of Credit Suisse. External appointments Member, International Advisory Board, Investcorp; Chair, Vega Cyber Associates AG. Skills and experience Vishal has a distinguished background in technology, particularly in Artificial Intelligence (AI) and Machine Learning (ML), which are central to GSK’s approach to R&D. He also brings a deep understanding of cyber security to the Board. He is the founder and CEO of Vianai Systems, Inc, a Silicon Valley-based company that provides advanced technological software and services in AI and ML to large enterprises around the world. Before founding Vianai Systems in 2019, Vishal served as CEO of Infosys Limited, where he led an innovative strategy to help clients renew existing IT landscapes, using automation, design thinking and next-generation technologies to transform customer experiences. He also served as a member of the Executive Board of SAP SE, prior to which he was its Chief Technology Officer. Vishal has a PhD in AI from Stanford University and has co-authored several research abstracts related to AI, technology and database management. External appointments Founder and CEO, Vianai Systems, Inc; Board Member, Oracle Corporation; Member, Supervisory Board, BMW AG; Member of the Advisory Board of Stanford University's AI Center (Center for Human-Centered Artificial Intelligence). Key Committee Chair C Corporate Responsibility S Science N Nominations & Corporate Governance A Audit & Risk R Remuneration Directors departing during 2023 Iain Mackay 14 January 2019 to 1 May 2023 Stepped down from the Board on 1 May and retired from the company on 31 December 2023. 111 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 GSK Leadership Team (GLT) Emma Walmsley Chief Executive Officer Julie Brown Chief Financial Officer Diana Conrad Chief People Officer James Ford SVP & Group General Counsel, Legal and Compliance Sally Jackson SVP, Global Communications and CEO Office Luke Miels Chief Commercial Officer Shobie Ramakrishnan Chief Digital and Technology Officer Skills and experience Emma joined GSK in 2010 and the GLT in 2011. See Board biographies on pages 108 to 111. Julie joined GSK and the GLT in 2023. See Board biographies on pages 108 to 111. Diana was appointed Chief People Officer and member of the GLT in April 2019. She was previously Senior Vice President, HR, Pharmaceuticals R&D from 2016 where she played a key strategic role as leader of the R&D people and culture agenda to support its transformation. Diana joined GSK Canada’s HR team in 2000 where she held several roles of increasing responsibility before becoming Senior Vice President, HR for Consumer Healthcare in 2009. Prior to joining GSK, she held HR roles in companies including GE Capital, Gennum Corporation and Zenon Environmental Laboratories. Diana has an Honours Bachelor of Arts from McMaster University in Canada. James joined the GLT in 2018, when he was appointed Senior Vice President and Group General Counsel, later taking responsibility for Compliance, Corporate Security and Investigations in 2021. He joined GSK in 1995 and has served as General Counsel Consumer Healthcare, General Counsel Global Pharmaceuticals, Vice President of Corporate Legal and was Acting Head of Global Ethics and Compliance. Prior to GSK, James was a solicitor at Clifford Chance and DLA. He holds a law degree from the University of East Anglia and a Diploma in Competition Law from King's College. He is qualified as a solicitor in England and Wales and is an attorney at the New York State Bar. James is based in London and has practised law and lived in the US, Singapore and Hong Kong. James was co-chair of the US-based Civil Justice Reform Group 2019-2022, and is a director of the European General Counsel Association and the Association of Corporate Counsel. Sally joined the GLT in March 2019 as Senior Vice President, Global Communications and CEO Office. She leads our Communications and Government Affairs function globally and is also the CEO’s Chief of Staff. Prior to this, Sally was Senior Vice President, Office of the CEO and CFO and she previously served as Head of Investor Relations. She joined GSK in 2001. Sally holds a degree in Natural Sciences from the University of Cambridge. Luke joined GSK and the GLT in 2017. As Chief Commercial Officer he is responsible for our commercial portfolio of medicines and vaccines. Luke also co-chairs the Portfolio Investment Board with Tony Wood and is a member of the ViiV Healthcare Board. Outside of GSK, Luke is a member of the Singapore Economic Development Board. He previously worked for AstraZeneca as Executive Vice President of their European business and, prior to that, was Executive Vice President of Global Product and Portfolio Strategy, Global Medical Affairs and Corporate Affairs. Before that, he was head of Asia for Roche, based in Shanghai and then Singapore. Prior to that he held roles of increasing seniority at Roche and Sanofi-Aventis in the US, Europe and Asia. Luke holds a Bachelor of Science degree in Biology from Flinders University in Adelaide and a MBA from the Macquarie University, Sydney. Shobie joined the GLT in 2021 when she was appointed Chief Digital and Technology Officer. She joined GSK in 2018 and has deep and broad experience in both biotech and hi-tech companies and, most recently, has led Digital and Technology for GSK’s Global Commercial organisation, transforming the company’s capabilities in digital, data and analytics and playing a pivotal role in establishing a more agile commercial operating model. Before joining GSK, Shobie held senior technology leadership roles in organisations including AstraZeneca, Salesforce, Genentech and Roche. She is a Non-Executive Director at Deliveroo. She is Board Member Emeritus at SustainableIT.org and was formerly a member of the board of directors at Remediant. Shobie holds a Bachelor’s degree in Electronics Engineering from Vellore Institute of Technology, University of Madras, India. 112 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 GSK Leadership Team (GLT) continued David Redfern President, Corporate Development Regis Simard President, Global Supply Chain Phil Thomson President, Global Affairs Deborah Waterhouse CEO, ViiV Healthcare and President, GSK Global Health Tony Wood Chief Scientific Officer Skills and experience David joined the GLT as Chief Strategy Officer in 2008 and is responsible for corporate development and strategic planning. Previously, he was Senior Vice President, Northern Europe with responsibility for GSK’s pharmaceutical businesses in that region and, before that, he was Senior Vice President for Central and Eastern Europe. He joined GSK in 1994. David was appointed Chairman of the Board of ViiV Healthcare Limited in 2011 and a Non-Executive Director of the Aspen Pharmacare Holdings Limited Board in 2015. He has a Bachelor of Science degree from Bristol University and is a Chartered Accountant. Regis joined the GLT in 2018, when he became President, Pharmaceuticals Supply Chain. He is responsible for the manufacturing and supply of GSK’s medicines and vaccines. In addition, he leads Quality and Environment, Health, Safety and Sustainability at a corporate level. Regis joined GSK in 2005 as a Site Director in France, rising to become Senior Vice President of Global Pharmaceuticals Manufacturing before his current role. Previously, he held senior positions at Sony, Konica Minolta and Tyco Healthcare. He is a member of the Board of ViiV Healthcare. He is a mechanical engineer and holds an MBA. Phil joined the GLT in 2011. He was appointed President, Global Affairs in 2017, and has responsibility for the Group’s strategic approach to stakeholder engagement, reputation and policy development. Previously, Phil was Senior Vice President, Communications and Government Affairs. He joined Glaxo Wellcome as a commercial trainee in 1996. Phil holds a degree in English, History and Russian Studies from Durham University. Deborah was appointed to the GLT in January 2020. She became Chief Executive Officer of ViiV Healthcare in April 2017. In addition to ViiV, Deborah also leads GSK’s Global Health organisation. Deborah joined GSK in 1996 and, prior to ViiV, was the Senior Vice President of Primary Care within GSK’s US business. She has a strong track record of performance in both specialty and primary care. Deborah led the HIV business in the UK before heading the HIV Centre of Excellence for Pharma Europe and held roles as General Manager of Australia and New Zealand and Senior Vice President for Central and Eastern Europe. Deborah is a Non-Executive Director of Schroders plc and holds a degree in Economic History and English Literature from Liverpool University. Tony was appointed Chief Scientific Officer (CSO), Head of R&D and a member of GLT on 1 August 2022, following his appointment as CSO designate on 19 January 2022. He joined GSK from Pfizer in 2017 as Senior Vice President, Medicinal Science and Technology, responsible for all science and technology platforms driving the delivery of new innovation. Tony has led large-scale global organisations in drug discovery and development in multiple therapeutic areas, including immunology, oncology and infectious diseases. During his time at Pfizer, Tony was responsible for the invention of a new antiretroviral medication used to treat HIV infection. He is a Fellow of the Academy of Medical Sciences, an Honorary Fellow of the Royal Society of Chemistry (RSC), the highest honour given by the RSC, and a Fellow of the Royal Society of Biology. Tony has a BSc in chemistry and PhD in organic synthesis from the University of Newcastle, and was a postdoctoral fellow at Imperial College, London. He is also currently a visiting professor at IMCM Oxford. GLT members departing during 2023 (1) Iain Mackay was a member of the GLT and CFO until 1 May 2023. He stepped down from the Board on 1 May and retired from the company on 31 December 2023. 113 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Chair’s governance statement In 2023 GSK continued to make significant progress as a pure biopharma company. The Board has the skills and capabilities to challenge and support GSK’s performance and long-term success. Board succession Two succession processes began in 2023. Urs Rohner, who has chaired the Remuneration Committee since May 2015, reaches just over nine years of service at the 2024 AGM. He will be succeeded following the AGM by Wendy Becker who joined the Board in October 2023. Wendy has a strong background in science, life sciences and technology, but is also a very experienced Remuneration Committee Chair with an understanding of global corporates. She will oversee the next iteration of the Remuneration policy that will be presented at the 2025 AGM. Our second succession planning focus has been for continued refreshment of the Board’s scientific expertise. Dr Laurie Glimcher, who stepped down from the Board in October 2022, was not replaced as we were unsure of precisely what additional skills we needed. As our focus deepens on RNA and oligonucleotides we have undertaken a detailed search for a scientist with deep experience in RNA. A successor to Dr Jesse Goodman, who is due to retire after nine years’ service at our 2025 AGM, will be sought in 2024. His expertise in public health, infectious diseases and regulation has been invaluable and necessary. Board priorities and focus GSK is now delivering meaningful and consistent improvement in performance which needs to be sustained through effective capital allocation and strategic choices. This was reflected in the recent upgrade to our longer-term outlooks announced at the beginning of the year. The Board and management agendas are completely aligned with clear focus on the three time periods that management communicate on – financial performance to 2026, pipeline progress and business development to support the growth ambitions to 2031 and the science and technologies that support the long-term growth of the business beyond 2031. The primary focus of the Board’s work in 2023 was on building confidence on the growth outlooks to 2031. The significant opportunities that can come from AI/ML have been a theme running through every Board meeting. Board evolution The Board’s composition will continue to evolve, but is now tailored to the pure biopharma company that we are now. We have the relevant skills and experience with deep industry and scientific expertise, as well as broad pharma business and commercial experience. At the heart of the business is science and the choices we make. We are well equipped with Drs Hal Dietz, Hal Barron and Jesse Goodman who provide a breadth and depth of scientific knowledge which combines well with Vishal Sikka’s deep expertise in technology, artificial intelligence and machine learning (AI/ML). Liz Anderson provides strong commercial expertise and Dr Anne Beal brings a strong focus on patients and the patient experience. Charlie Bancroft’s extensive expertise as a pharma company executive and CFO means that our Board now meets the needs of GSK today. At the management level we transitioned CFO from Iain Mackay, who guided us through the separation of Haleon, to Julie Brown, who has deep industry expertise. Board industry experience l 2022 pre-biopharma Board l 2023 biopharma Board Non-Executive Director tenure l Up to 3 years: 50% l 3-6 years: 20% l 6-9 years: 20% l Over 9 years: 10% 2023 Board priorities Focus on value creation, governance and oversight of Ahead Together strategy Delivery of performance targets Execution of R&D pipeline and business development Long-term R&D strategy and approach End-to-end business impact of AI/technology People/Talent/Culture ESG leadership Zantac litigation – defence and mitigation Focus on shareholder value creation 114 Pharma/Life SciencesTechFinanceConsumer/Other0246810Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Chair’s governance statement continued The Board supported the modular communication plan for 2023, which included deep insights into vaccines and infectious disease, HIV, respiratory, immunology and oncology. The Board reviewed all of the strategies and priorities prior to communication to the market. The revised outlooks presented with the 2023 annual results were also reviewed extensively in the second half of the year along with the longer-term strategic plan. In terms of business development, the Board and Science Committee work alongside Emma and the management team to understand the scientific rationale, competitiveness of the asset under consideration and potential returns and value creation. This was a significant activity of the Board in 2023. Board visits are an important element of our Board programme. In March the Board spent three days visiting our Vaccines site in Wavre, Belgium. Board members had a deep immersion in the vaccines business and the work at the site and were inspired by the passion and commitment of the group of around 150 employees they spent time with during the visit. Similarly, the Board will be holding its March meeting in 2024 in North Carolina for an immersive briefing on our HIV business. R&D progress and Technology The longer-term future of the company comes from deep sustainable productivity of internal and externally sourced R&D and from our investment in technology. The path we set out on five years ago was routed in our commitment to transform our productivity through the use of technology. Last year the Board’s R&D updates centred on antibody drug conjugates, Oligonucleotides, AMR, Vaccines and RNA and liver disease. These discussions were supported and validated by prior deep-dives by the Science Committee. Embracing the potential of AI/ML in every part of the business is crucial to our medium and long-term success. We deliberately have a wealth of tech experience on the Board ranging from Dr Hal Barron’s R&D experience at Verily and Google, to Vishal Sikka’s unique tech vantage point and expertise in AI and ML. Our CEO also brings unique insights from her role at Microsoft, along with my own experience of the use of technology in biotechs and through the UK’s national genomics programmes. Collectively the deep appreciation of the tremendous potential that technology can unlock give us the reassurance to execute with confidence. While our biggest investment has of course been in R&D, every part of GSK now has technology built into optimising their priorities. Culture & responsibility The Board receives regular briefings on our people, talent and culture. At every Board interaction, wherever we are, the Board meets between 50 to 100 members of local employee talent. This enables us to get a first hand impression of our culture and the mood of employees and to hear their views of the company. Similarly, wherever I go in GSK, and this year my travels included the US, China, the Middle East and Europe, I take the opportunity to meet with local employees at all levels in small groups. It is impressive to hear those I meet all talk with pride in our purpose and our mission towards prevention and improved human health. ESG continues to be right at the very heart of GSK and its ambition. We are particularly proud of the progress that we are making in DEI in terms of our people, and in the diversity of our clinical trials. Shareholder perspectives and engagement The Board and I believe in the importance of maintaining a continuous level of engagement with shareholders. During the year I continued to meet with a range of investors; combined they represented approximately 30% of our share register. This year all our Non-Executive Board members attended our Annual Governance Meeting to hear shareholders views first hand. The feedback shareholders provide is invaluable to the shaping of the Board’s work. We appreciate the clarity and efficiency that direct engagement brings and we continue to welcome the opportunity to engage with investors directly on all aspects of GSK and the Board’s work. We welcome the approach taken by the Financial Reporting Council in its updated UK Corporate Governance Code to encourage Boards to be bolder in choosing the right approach for their business and explaining why it is important to do so if necessary. Shareholder value We have made progress in 2023 but there is, and will always be, more to do. The key to improved returns is consistency of performance, and consistency in communication. During 2023, I believe management delivered on both, but this all has to be translated into sustained shareholder value creation. We are acutely aware that has not happened yet. In terms of the Zantac litigation, the Board is deeply involved in the overall strategy with the CEO and General Counsel. In addition, every quarter the Audit & Risk Committee reviews the disclosures with our Auditor to ensure that they are complete, fair and that the accounting judgments are appropriate. I believe 2023 was a year of significant progress across all of the time periods to 2026, 2026 to 2031 and beyond 2031. We have a clear and aligned work programme for 2024. The Board is very different to what it was two years ago. I am really delighted not just with the progress Emma and the management team have made, but the performance of the Board too. I encourage you to read my Board colleagues' committee updates (which follow on pages 128 to 138) and provide greater detail on their work during 2023. Thank you for your continued support and I look forward to connecting with you during the year, whether at our Annual General Meeting in May, or otherwise. Sir Jonathan Symonds Chair 27 February 2024 115 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Corporate governance architecture Our corporate governance architecture is a framework designed to improve the Board's effectiveness and to support its oversight of the GSK Leadership Team (GLT) as it delivers the company's strategy. This framework continues to evolve to support our infrastructure and priorities as a pure biopharma business. GSK’s internal control and risk management arrangements are integral to our overall corporate governance framework and are described on pages 57 to 76 and pages 134 and 135. To ensure the framework's optimal effectiveness, it has: – a clear division of responsibilities for individual and collective Board roles, as described on page 117 – the appropriate distribution of workload to the Board committee with the requisite focus and skills – highly committed Board Directors who are motivated to carry out their roles and responsibilities for the success of the company Committee roles Committee Role and focus Chairs’ Acts on behalf of the Board between its scheduled meetings to take decisions on urgent matters in accordance with matters and authority delegated to it by the Board from time to time Corporate Responsibility Considers GSK's Trust priority and has oversight of our responsible business approach and ESG strategy, performance and reporting. This reflects the most important issues for responsible and sustainable business growth. Has oversight of the views and interests of our internal and external stakeholders, and reviews issues that could have a serious impact on GSK’s business and reputation Membership Sir Jonathan Symonds (company Chair) Senior Independent Director Chairs of the Board's committees Dr Anne Beal (Chair) Dr Jesse Goodman Dr Vishal Sikka Science Supports the Board in its understanding of business development transactions and the key strategic themes on which the company's R&D strategy is based, by reviewing underlying scientific assumptions in detail and giving the Board technical assurance. Has in-depth oversight of R&D-related risks Dr Hal Dietz (Chair) Dr Jesse Goodman Dr Hal Barron Nominations & Corporate Governance Reviews the structure, size and composition of the Board, the appointment of members to Board committees and the appointment of corporate officers. Makes recommendations to the Board as appropriate. Plans and assesses orderly succession for Executive and Non- Executive Directors and reviews management's succession plan to ensure its adequacy Is responsible for overseeing, monitoring and making recommendations to the Board on corporate governance arrangements. Reviews Board and GLT conflicts of interest Audit & Risk Reviews the financial reporting process, the integrity of the company’s financial statements, the external and internal audit process, the system of internal control, and the identification and management of risks such as Information and cyber security, and the company’s process for monitoring compliance with laws, regulations and ethical codes of practice Oversees ESG data reporting and assurance. Initiates audit tenders, the selection and appointment of the external auditor, setting the auditor's remuneration and overseeing its work Remuneration Sets the company’s Remuneration policy having regard to GSK’s workforce remuneration so that GSK is able to recruit, retain and motivate its executives Regularly reviews the Remuneration policy to make sure that it is consistent with the company’s scale and scope of operations, supports the business strategy and growth plans, is aligned to the wider workforce and helps drive the creation of shareholder value (The Chair and the CEO are responsible for evaluating and making recommendations to the Board about remuneration arrangements and policy for the Non-Executive Directors) Sir Jonathan Symonds (Chair) Charles Bancroft Dr Anne Beal Urs Rohner Charles Bancroft (Chair) Elizabeth McKee Anderson Wendy Becker Urs Rohner Urs Rohner (Chair) Wendy Becker (Chair Designate) Charles Bancroft Dr Anne Beal Elizabeth McKee Anderson Committee report on page – 128-129 129-130 131-132 133-138 139-160 Each Board committee has written terms of reference that are approved by the Board and reviewed at least annually to make sure they comply with the latest legal and regulatory requirements and reflect best practice developments. Terms of reference of each Board committee are available at gsk.com. 116 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Corporate governance architecture continued Leadership Chair Jonathan Symonds – leads and manages the business of the Board – provides direction and focus – ensures a clear structure for the Board and its committees to operate effectively – maintains a dialogue with shareholders about the governance of the company – sets the Board agenda and ensures sufficient time is allocated to promote effective debate to support sound decision-making – ensures the Board receives accurate, timely and clear information – meets regularly with each Non-Executive Director to discuss individual contributions and performance, and training and development needs Independent oversight and rigorous challenge Senior Independent Director Charles Bancroft – acts as a sounding board for the Chair and a trusted intermediary for other Directors – together with the Non-Executive Directors, leads the annual review of the Chair’s performance, taking into account the views of the Executive Directors – discusses the results of the Chair’s effectiveness review with the Chair – leads the search and appointment process and makes the recommendation to the Board for a new Chair – acts as an additional point of contact for shareholders. Maintains an understanding of their issues and concerns through meetings with shareholders and briefings from the Company Secretary and Investor Relations + GSK's Senior Independent Non-Executive Director’s role description is – shares peer feedback that is provided as part of the available at gsk.com Board evaluation process – meets regularly with all the Non-Executive Directors independently of the Executive Directors + The Chair’s role description is available at gsk.com Chief Executive Officer Emma Walmsley – manages the Group and its business – develops the Group’s strategic direction for the Board's consideration and approval – implements the agreed strategy – is supported by the GLT – maintains a continuous dialogue with shareholders in respect of the company’s performance + The Chief Executive Officer’s role description is available at gsk.com Non-Executive Directors – provide a strong independent element to the Board – constructively support and challenge management and scrutinise its performance in achieving agreed deliverables – shape proposals about strategy and offer specialist advice to management – each has a letter of appointment setting out the terms and conditions of their directorship – devote such time as is necessary to the proper performance of their duties – are expected to attend all meetings as required Independence statement The Board considers all its Non-Executive Directors who are identified on pages 108 to 111 – except Dr Hal Barron – to be independent after being assessed against Provision 10 of the Financial Reporting Council's (FRC) UK Corporate Governance Code (Code) + GSK's Non-Executive Directors' role description is available at gsk.com Company Secretary Victoria Whyte – is secretary to the Board and all Board committees – supports the Board and Committee Chairs to plan future agendas and annual programmes – ensures information is made available to Board members in a timely fashion – supports the Chair to design and deliver Board inductions – coordinates continuing business awareness and training for the Non-Executive Directors – undertakes internal Board and committee evaluations at the Chair's request – advises the Directors on Board practice and procedures and corporate governance matters – chairs the Group's Disclosure Committee – operates a Board-approved appointments policy that reflects the Board and external appointment requirements of the Code – is a point of contact for shareholders on all corporate governance matters 117 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Corporate governance architecture continued 2023 Board and committee attendance Board 6 Chairs’ 3 Corporate Responsibility 4 Science 3 Nominations & Corporate Governance Audit & Risk Remuneration 5 6 5 Attended Attended Attended Attended Attended Attended Attended Total number of routine meetings Current members Sir Jonathan Symonds Emma Walmsley Julie Brown (from 1 May) Elizabeth McKee Anderson Dr Hal Barron Charles Bancroft Dr Anne Beal 6 6 4 (4) 6 6 6 6 Wendy Becker (from 1 October) 2 (2) Dr Harry Dietz Dr Jesse Goodman Urs Rohner Dr Vishal Sikka Retired members Iain Mackay (until 1 May) Number of additional meetings 6 6 6 4* 2 (2) 4 3 3 3 3 1 – 3 3 3 6 4 4 2 1 5 5 5 5 – 6 6 5 5 5 2 (2) 2 (2) 6 3 5 1 For those Directors who served for part of the year, the numbers in brackets show the number of meetings the Directors were eligible to attend. Details of committee members’ skills and experience are included in their biographies on pages 108 to 111. There was a high attendance record at scheduled Board and committee meetings for all our Directors who served during 2023, as set out above. In January 2024, Urs Rohner has reached nine years of service and will step down from the Board at the 2024 AGM as planned. He continues to demonstrate all the characteristics of independence expected by the Board in carrying out his role on the Board. *Dr Vishal Sikka joined the Board in July 2022. During his first year on the Board he was unable to attend two Board meetings because of pre-existing external board commitments. He contributed fully to the Board’s work during 2023. He met regularly with the Chair to provide his input on Board and Committee materials. He inputted on technology and AI discussions at the Audit & Risk Committee. He also spent time with our Chief Digital and Technology Officer and her team during the year, sharing his expertise and perspectives. FRC UK Corporate Governance Code Financial experience In accordance with the FRC's Code, the Board determined that Charles Bancroft has recent and relevant financial experience. It has also agreed that he has the appropriate qualifications and background to be an audit committee financial expert as defined by the Sarbanes-Oxley Act of 2002, and has determined that he is independent within the meaning of the Securities Exchange Act of 1934, as amended. Members of the Audit & Risk Committee also have financial and industry experience, details of which can be found in their biographies on pages 108 to 111. Compliance statement The Board is pleased to report that in 2023 it was in full alignment with the provisions of the FRC's Code. The Board is also pleased to report that it has consistently applied the principles of the FRC's Code, as set out on the pages of this Corporate Governance report. A copy of the Code is available on the FRC’s website at www.frc.org.uk. Board appointments policy All our Non-Executive Directors are expected to devote such time as is necessary for the performance of their duties. Each Director is required to attend a minimum of 75% of scheduled Board and committee meetings. However, it is recognised that there may be rare occasions when this is not possible, as explained above in the attendance table. Special allowance is also given during the first year of Board membership while calendars are aligned. Our Board Directors’ external appointments are governed by a Board-approved policy. It is considered that external appointments can help Board and GLT members widen their expertise and knowledge, and hence perform their roles more effectively. When proposing new Non-Executive Director appointments to the Board for approval, the Board considers the other demands on the individuals’ time. Before being appointed to the Board, an individual is required to disclose the significant commitments they may have with an indication of the time involved. Subsequently, all additional prospective external appointments for serving Board Directors are considered and approved by the Board, noting the nature of the role and type of organisation, time commitment and any potential conflicts that could arise. The Company Secretary maintains a register of commitments and potential conflicts. The Board is satisfied that given Directors’ other interests, each has sufficient time to carry out their role with GSK. Our Executive and Non-Executive Directors may undertake a maximum of one or up to four other listed-company directorships respectively. 118 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Ahead Together – Board oversight The Board carries out its responsibilities through an annual programme of meetings The Board seeks to optimise its effectiveness by setting its annual meeting programme to focus on priorities agreed for the year to support delivery of the company's short-, medium- and long-term strategy. The Board and its committees' programmes of work are set to complement each other and avoid unnecessary duplication. During the year the Board received papers and presentations and actively discussed progress with management and our people. These materials and discussions help the Board make effective decisions, and contribute to its oversight of business performance and ensure good governance. The key areas the Board considered in 2023 are highlighted below: Areas of focus in 2023 Building momentum as a pure biopharma company Ahead Together – further strengthening the fundamentals of value creation Enhancing ESG leadership Regular corporate governance oversight The Board's work in 2023 included: Overseeing GSK as a pure biopharma business and delivery of performance included: – setting and approving the Board's 2023-2024 priorities – discussing and scrutinising strategic plans for GSK and assessing the potential to upgrade our longer-term outlook – scrutinising updates on R&D strategy, progress and progression of the company's pipeline – discussing GSK's overall commercial strategy and in particular for China – discussing end-to-end business opportunities and the impact of AI and other advanced technologies for performance and patients Overseeing the fundamentals of commercial execution, cost-base management, capital allocation, pipeline and culture included: – receiving regular reports from the CEO, CFO and CSO including the assessment of delivery of performance targets – receiving updates on R&D strategy, approach and pipeline progress – assessing the product area strategy reports on Vaccines, Speciality Care (including HIV), Oncology and General Medicines – reviewing GSK's capital allocation priorities to ensure investment for growth to deliver improved returns for shareholders – evaluating business development transactions, acquisitions and strategic partnerships with third parties including BELLUS Health, Zhifei, Hansoh, Aiolos Bio, Arrowhead Pharmaceuticals and Janssen Pharmaceuticals – scrutinising the Group's financial performance, shareholder value creation and development of Investor Relations Roadmap – reviewing Zantac litigation strategy – approving the monetisation of the retained shares in Haleon post demerger of the Consumer Healthcare business Overseeing culture and embedding ESG at our core included: – assessing ESG performance and reviewed plans for low-carbon Ventolin, including clinical and non-clinical data available to support regulatory submissions – approving the ESG Performance Report – oversight of the company's Pricing and Access Policy principles – reviewing stakeholder perception research The Board’s programme of governance included: – reviewing the quarterly financial results, dividend proposals, earnings guidance, investor materials, results announcements and 2022 Annual Report and Form 20F and receiving related reports from the external auditor – setting the annual budget and the forward-looking three-year plan and long-range forecast – conducting an annual review of the enterprise risk responsibility framework and enterprise-wide risks – undertaking an annual Board evaluation and implementing its agreed outcomes – receiving reports on Board committee work and reviewing and continuing to evolve the Board’s governance architecture – evaluating the CEO’s 2023 performance, and setting her 2024 objectives – reviewing culture, talent and succession plans annually – engaging with GSK's stakeholders and people to gather and understand their views about the company’s activities, operations and culture – reviewing the employee pulse survey results – receiving reports on wider corporate governance and regulatory developments, and the Company Secretary’s report – approving the company's modern slavery statement and gender pay gap positioning 119 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Ahead Together – Board oversight continued Board performance The Board evaluates its performance, and that of its committees, every year. The evaluation is normally carried out externally every third year. The most recent external evaluation was facilitated in 2022 by Jan Hall of No 4, a business advisory company that does not have any other connection with GSK. The 2023 Board and committee evaluation was conducted internally by the Company Secretary who: – provided a questionnaire to Board members – drew together responses and themes from the responses to discuss outcomes and recommendations with each Committee Chair – following discussion with each committee and the Board as a whole, identified areas of focus and improvement for the Board and committees, which are set out below Action points After due consideration and discussion, the following action points to further improve performance in 2024 were agreed: – the key priorities for the Board's focus and programme of meetings for the year ahead – given the fundamental importance of culture, the Board wished to ensure it too fully embodied GSK's culture and would therefore undertake the culture training provided to employees – additional opportunities to increase informal engagement between the Board and management – the removal of unnecessary duplication in the Board and its committees' work would be continued. This programme aims to further simplify papers and create time to have deeper discussions in meetings Board committee evaluations The review of the Board committees focused on potential opportunities to further support GSK's momentum as a pure biopharma company, to help remove duplication and support the delivery of the Board's priorities identified for 2024. In addition, each committee reviewed its committee members' tenure, expertise and diversity. Each committee was considered to have operated effectively and the following enhancements were agreed: – Corporate Responsibility Committee: has a wide remit and was performing well. Consideration would be given to additional routes to identify potential emerging issues within the Committee's area of responsibility for its review. In addition, the Committee would continue to seek external perspectives to provide challenge – Science Committee: was working effectively. Opportunities to further enhance effectiveness were considered. In particular the Committee's 2024 programme would focus on R&D's Tech strategy. The capacity to undertake more deep dives on specific areas of R&D activity and to input earlier into new projects would be explored – Nominations & Corporate Governance Committee: was working effectively. A successor to Dr Jesse Goodman was being sought ahead of his retirement from the Board in 2025. The Committee would undertake a review of the Board and committee architecture and membership in 2024 to ensure it remained aligned to Board priorities – Audit & Risk Committee: was considered to be effective. The work to appropriately streamline material reviewed by the Committee has made good progress and will continue as an area of opportunity. In the year ahead the Committee will also continue to give focus on tech, cyber security and the use of AI – Remuneration Committee: had operated effectively during 2023 despite a challenging environment. The focus for 2024 would be to determine the right business imperatives for GSK's next remuneration policy to ensure it was globally competitive and rewarded delivery of outperformance Chair's evaluation The Senior Independent Director (SID) carried out the Chair's evaluation. He sought feedback on the Chair's performance from the Directors individually and collectively. From this review, they concluded that the Chair was leading the Board appropriately and effectively. The Chair and SID discussed the results of the review. 120 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions Prioritising continuous engagement Our stakeholders rightly have high expectations of us, and the company's dynamic operating environment presents many challenges and opportunities. As a Board we aim to make sure that being commercially successful is balanced and aligned with meeting our stakeholders’ expectations, upholding our reputation, maintaining our licence to operate and building trust. We engage with or are briefed about our stakeholders' views to make sure we identify and respond to their expectations effectively and appropriately. How we engage with our main stakeholder groups – including patients, shareholders, consumers, customers and our people – across the company is covered in the pages of the Strategic report. Patients and our people are two stakeholders at the heart of our culture, with all our people ambitious for patients, accountable for outcomes and committed to doing the right thing. Our culture is described on pages 14 and 15 of the Strategic report. The influence and importance of different stakeholder groups can vary, depending on the matter being considered. Certain stakeholders’ interests can be in conflict, meaning that we, as a Board, need to make balanced judgements. Continuous stakeholder engagement and feedback helps us identify emerging issues. It also enables us to make decisions in the context of what is relevant and important to each of them. Our principal Board committees, and the GLT, undertake engagement on the Board’s behalf according to their remit. This means that they can build a detailed understanding of how our actions or plans are affecting or might affect stakeholders. These insights are then shared with the Board. In particular, the Board receives briefings on stakeholders’ perspectives from the work of the Corporate Responsibility Committee, which is discussed on pages 128 and 129. Board members regularly receive: – the CEO’s Board report – a specific external stakeholder insights report. This provides strategic insights based on an analysis of key developments, achievements and risks affecting our reputation and the perceptions of all our external stakeholders – a regular investor relations report which summarises investor perceptions – regular corporate governance, litigation and regulatory updates The Board also learns of stakeholders' views through: Engagement and feedback events: such as quarterly investor results calls, the Annual General Meeting, employee survey reports, the Board’s workforce engagement activities, and from experts presenting at Board or committee meetings. The Chair also holds regular investor check-in meetings, which the SID, Charlie Bancroft, sometimes joins, and is available for individual meetings with investors. Other opportunities: Board members also gain wider stakeholder views during the annual strategy meeting with the GLT, as part of the yearly review of strategy, budget and planning processes. This also includes a review of specific aspects of the company’s policies or strategy. In addition, Board members are encouraged to meet individually with employees, shareholders and other key stakeholders during their induction, and then on an ongoing basis. They are encouraged to report to the Board on such experiences where relevant and material. Engaging with our people We have well-established and strong engagement mechanisms with our employees, which are described on pages 14 and 15, and which the Board monitors regularly. Four key governance channels help the Board understand what our people are thinking: – regular Board updates from our Chief People Officer and the CEO on culture and talent – feedback from an annual employee engagement survey, including questions on engagement, confidence and inclusivity – a range of pulse surveys of different-sized employee groups to help check sentiment on a quicker and more frequent basis, and to provide valuable insights on the impact of major initiatives, events or communications – direct engagement by the Board Workforce engagement: Before the company's demerger, the Board reviewed its formal workforce engagement arrangements. It was decided to move from a specific Workforce Engagement Director model and to apply an ‘alternative arrangement’ to the three methods set out in the FRC’s Code. Given that the new GSK Board was recently refreshed in terms of tenure, with more than half the independent Non-Executive Directors having served for less than three years, and given GSK's renewed purpose and focus as a global biopharma company, it was considered important to adopt a collective Board engagement model. This was agreed to be the most effective approach to ensure newer Board members meet employees and hear their views. This new model operated in 2023 through: – direct in-person receptions with local employees during Board site visits, including in Wavre, Belgium (as one of our two global Vaccines hubs), Boston, US, and our global headquarters in Brentford – the Chair's site visits, including to the Wavre and Singapore Vaccine manufacturing sites, and the Philadelphia Commercial site – the Chair's attendance at management meetings, including China Commercial employees, the Commercial Core Leadership team in the UK, China regional general managers and Commercial talent and Saudi Arabia general management team – the Chair and Corporate Responsibility Committee Chair convene and attend ongoing meetings with leaders of the company's employee resource groups to talk about how they experience GSK, how they think the DEI agenda and ambitions are progressing and sharing their suggestions to further enhance our DEI agenda – utilising a variety of bespoke engagements that have enabled a broad and open dialogue and facilitated first- hand engagement discussions between the NEDs and our people individually and as part of small groups, encompassing perspectives on our strategy, purpose and Ahead Together culture, and DEI 121 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions continued Engaging with our shareholders As a Board we aim to directly engage with and be directly accountable to institutional investors and private retail shareholders. We do this in several ways, including regular communications, the Annual Governance Meeting, our Annual General Meeting, and through the work of our Investor Relations team, the Chair, Jonathan Symonds, and our Company Secretary, Victoria Whyte. Our SID, Charlie Bancroft, is another point of contact for our shareholders. Each quarter, our CEO, Emma Walmsley, and CFO, Julie Brown, give results presentations to institutional investors, analysts and the media by webcast. They are also regularly joined by the CSO, the Chief Commercial Officer (CCO), and CEO, ViiV. They are able to provide investors with more detailed insights into their specific areas of responsibility. Through regular meetings, they each have an ongoing and active dialogue with institutional shareholders about the company's performance, plans and objectives. In 2023, Annual Governance Meeting This year’s hybrid meeting was held in central London. Institutional shareholders, key investment industry bodies and proxy advisory firms were invited. 15 representatives of various institutional shareholders and proxy advisers attended the event, comprising approximately 25% of the company's share register. The meeting had a new format to make it as interactive as possible. It began with Jon sharing with investors the Board's priorities and focus for 2023 and beyond, with Charlie then providing his reflections on the year. Jon, Charlie and our Non- Executive Directors then held an informal and open discussion of those issues on shareholders' minds, which helped foster a richer dialogue. The key themes covered included the: – Board changes and succession planning arrangements – work of and challenges for the Board over the last year – company's current and future momentum and excellent – CEO: 103 engagements, representing 38% of the company's execution of our key priorities share register – harnessing of digital, technology and talent, driven by our – The current and previous CFO: 60 and 51 engagements, Ahead Together purpose comprising 33% and 31% of the register – CSO: 90 engagements, representing 31% of the register – CCO: 80 engagements, representing 39% of the register – CEO, ViiV: 61 engagements with 39% of the register Our Chair maintains a consistent dialogue with shareholders too – including fund and portfolio managers – and regularly engages with governance and ESG professionals. During 2023 and up to the date of publication of this Annual Report, Jon held over 30 individual engagements with a range of institutional shareholders, which make up approximately 30% of the company’s share register. This enables him to gain a current understanding of shareholders' views, insights and perspectives of the company. He also discusses the continual evolution of the many aspects of Board governance, performance oversight and succession. This year our Chair, CEO and the rest of the Board and key GLT members focused on communicating the strong ongoing performance of GSK as a global biopharma business, the successful launch of Arexvy, the world's first RSV vaccine, and progressing our pipeline across the core therapy areas of infectious diseases, HIV, respiratory/immunology.and oncology. – positive signs of the influence of our culture of being ambitious for patients, accountable for impact and doing the right thing The meeting and its new format were well received and shareholder feedback was shared with the full Board. Annual General Meeting We were pleased to hold the company's hybrid AGM at the Sofitel Heathrow in May 2023. 72 shareholders joined the meeting in person and 49 shareholders joined virtually via the Lumi platform to watch or listen to updates from our Chair and the CEO, and to vote. Shareholders were able to ask questions during the meeting in person and virtually. All our proposed resolutions were approved by shareholders, with majorities ranging from 89% to 99%. Our hybrid AGM this year will be held at a new venue, Royal Lancaster Hotel in Central London, which is located close to our new global headquarters. For more details see page 298. 122 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions continued Section 172 statement Board members are required by law to promote the success of their company for the benefit of both shareholders and wider stakeholders, including employees, suppliers and society. This statement meets the requirement, as set out in Section 172 and Section 414CZA of the Companies Act 2006 (Act). It summarises how, during 2023, our Directors addressed the matters set out in Section 172(1) (a) to (f) of the Act when performing their duties. The Board considers that this statement focuses on those risks and opportunities that are strategically important to GSK, consistent with the Group’s size and complexity. This allows it to properly understand the potential effects of the decisions it makes on all stakeholders. The details of our engagement with our main stakeholder groups, including our patients, shareholders, consumers, customers and employees across the organisation, is summarised generally throughout the pages of our Strategic report. The Board's continuous engagement with the company's shareholders and people in particular is set out in this section on pages 121 to 127. Our corporate governance architecture and processes are summarised on pages 116 to 118. The Board seeks to consider all relevant matters when making decisions, most especially when these are to continue to drive performance and momentum for GSK into the future. (a) Long-term results The likely consequences of any decision in the long term In a challenging economic and political landscape, the Directors recognise the criticality of investing in a pipeline of vaccines and medicines to prevent disease as well as meeting the changing and unmet healthcare needs in support of GSK’s purpose, our Ahead Together strategy and ultimately the long-term success and sustainability of GSK. At the same time, GSK works with governments, regulators and industry partners to ensure our medicines and vaccines can reach patients at scale, bringing value to both the patients who need them and to payers Our Directors appreciate that assessing the consequences of their long-term decisions in this environment can be multifaceted, finely balanced and invariably involves a trade- off between competing stakeholder interests To support their decision-making, Directors are provided with papers/information that, as a minimum, describe the long-term proposal under consideration and comment on how it: – fits with/strengthens or otherwise impacts the business strategy, budget and the three-year plan if relevant – is aligned with our Ahead Together ambition and outlooks Our Directors are also apprised of success and risk factors and, if appropriate, alternatives considered and the rationale for (b) Our workforce Interests of our people Our Directors understand that our people are at the core of our Ahead Together ambition, helping to power our purpose and delivering on our strategy and seek to create and oversee an environment at GSK in which outstanding people can thrive. A positive employee experience is critical to attract, retain and motivate the best people Papers/information relevant to this duty are normally submitted to the Board by the Chief People Officer or Head of Reward for input, challenge and decision or awareness by our Directors the proposed choice, highlighting any relevant stakeholder impacts of the proposal under consideration, whether positive and/or negative. The Directors then have all the relevant factors for consideration during their decision-making process Papers/information relevant to this duty are normally submitted by the CEO; CFO; Chief Scientific Officer; Chief Commercial Officer; President, Corporate Development; President, Global Affairs, or other GLT members and/or their direct reports for input, challenge and decision or awareness of the Directors Matters considered by our Directors include: – Pipeline progression reviews – Budget planning – Business development deals – Capital allocation priorities – Commercial (Vaccines, General Meds and Specialty) reviews – Dividend policy – ESG ambitions, including our six areas of ESG focus For more specific details see our Ahead Together and business model disclosures on pages 1, 8 and 9 Matters considered by our Directors include: – Culture progress – Talent pipeline – Diversity, equity and inclusion ambitions – Ethnicity and gender pay gap data, trends and reporting – Employee engagement practices and feedback – Health and safety risks – Pay fairness and benefits – Performance with choice and the workplace environment For more specific details see our culture and people, diversity, equity and inclusion and engaging with our people disclosures on pages 14 and 15, 52 and 53 and 121 123 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions continued (c) Our business relationships The importance of developing the Group’s business relationships with suppliers, customers and others Patients are placed by GSK at the heart of our purpose and culture, where we are all ambitious for patients, accountable for our impact and do the right thing Our suppliers and other key stakeholders – including governments, NGOs, healthcare authorities, healthcare professionals, R&D joint venture partners, affiliate companies and others – help us research, develop, manufacture, regulate, provide access and distribute the medicines, vaccines and other products that patients need A key imperative for our Directors, as custodians of a responsible business, is to ensure the company develops and monitors these relationships and partnerships to ultimately serve patients. In line with our Code of Conduct, our suppliers are expected to meet our Anti-bribery and corruption and labour rights standards and to comply with our standards on quality, health and safety, and the environment (which are explored in further detail below). In helping to foster good relations with suppliers we offer preferential payment terms to designated smaller suppliers in the UK and US Papers/information relevant to this duty are normally submitted by the CEO; CFO; President; Global Supply Chain; Chief Commercial Officer; Chief Scientific Officer; President, Global Affairs and/or their direct reports for input, challenge and decision or awareness by our Directors Matters considered by our Directors include: – Access to healthcare – Ethical standards – Global health and health security – Human rights – Modern slavery act statement – Product governance – Scientific and patient engagement – Supplier payment policy – Third-party risk management programme – Working with third parties policy For more specific details see our responsible business disclosures on pages 45 to 55 (d) The community and the environment The impact of the Group’s operations on the community and our environment The environment is one of our principal ESG focus areas. ESG is embedded in our strategy and fundamental to our success. To get ahead of disease and to help ensure this long-term success, our Directors recognise that as a responsible business we need to consider ESG impacts across everything we do. This extends from the lab to patients, by taking action on climate and nature Our manufacturing sites have a key role in our contribution to a net zero, nature positive, healthier planet, and environmental sustainability is a fundamental part of our global supply chain strategy. Supplier action will in turn help GSK achieve its environmental goals on climate and nature. This is embodied in GSK’s Sustainable Procurement Programme which, in its first full year in operation, has seen our suppliers take action on carbon, power, heat, transport, water, waste, and sustainable, deforestation-free sourcing of materials in support of our environmental sustainability goals Our Directors believe the company should be reflective of and support the diversity in the local communities in which we serve. In doing so, we are strengthening early STEM education investments to further support a long-term diverse talent pool and increase the positive impact of volunteering activities within our communities. We are also investing in plans to improve natural habitats, protect biodiversity and improve soil and water quality near our manufacturing sites Papers/information relevant to this duty are normally submitted by the President, Global Affairs; President, Global Supply; and Chief People Officer and/or their direct reports for input, challenge and decision or awareness by our Directors Matters considered by our Directors include: – Community investment and donations policy – Clinical trial diversity planning and enrolment – Diversity, equity and inclusion strategy – Environment, net zero and nature positive goals – Environment, health and safety risks – Emerging climate and environmental legislative/regulatory reviews For more specific details see our responsible business and climate and nature-related financial disclosures on pages 45 to 55 and 62 to 75 124 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions continued (e) Our reputation Our desire to maintain our reputation for high standards of business conduct As a responsible company, GSK seeks to be a force for good, with ambitious targets for positive impact on the health of people, society and the planet. The company manages risks effectively, takes action if things go wrong and seeks to respect human rights. Our Directors periodically review the continuing appropriateness of the frameworks underpinning our high standards of business, such as our Code of Conduct, including a range of policies and standards, and the architecture of our corporate governance arrangements Papers/information relevant to this duty are normally submitted by the CEO; CFO; General Counsel; Chief Commercial Officer; President, Global Affairs; Chief People Officer; Chief Digital and Technology Officer; Chief Compliance Officer; the Company Secretary; and Head of Audit & Assurance for input, challenge and decision or awareness by our Directors Matters considered by our Directors include: – Audit & Assurance plan – Code of Conduct – Corporate and financial statements – Corporate governance and regulatory updates – Enterprise risk assessments – ESG ambitions, including our six areas of ESG focus – Emerging ESG legislative/regulatory reviews – Internal control and risk effectiveness reviews – Speak Up and internal investigations For more specific details see our responsible business and corporate governance architecture disclosures on pages 45 to 55 and 116 to 118, and our separate ESG Performance Report (f) Fairness between our shareholders Our aim to act fairly as between members of the Group Our Directors seek to act fairly between the interests of all shareholders – major and retail shareholders alike. There is regular and constructive dialogue with shareholders to communicate our strategy and performance to receive investor views and perspectives, promote investor confidence, ensure our continued access to capital and inform our Directors' decision-making on strategic matters. As they do so, our Directors navigate and weigh up a range of shareholder opinion to arrive at decisions that support the long-term success of the company Papers/information relevant to this duty are normally submitted by the CEO, CFO, President, Global Affairs, Head of Investor Relations and the Company Secretary for input, challenge and decision or awareness by our Directors Matters considered by our Directors include: – Annual general meeting – Annual governance meeting – Capital markets days and meet the management events – Group and individual Director shareholder meetings – Investor and analysts perception surveys – Investor relations plan – Remuneration policy proposals For more specific details see our shareholder engagement and shareholder information disclosures on pages 122 and 295 to 314 125 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions continued Key decisions In its decision-making, the Board focuses on GSK's priorities as a pure biopharma company with strong momentum and big ambitions, whilst balancing the interests of our stakeholders. Selected examples of some of the key decisions taken by the Board in 2023 and January 2024 to drive our purpose, momentum and strategy include: Decision How the Board/Committee regarded stakeholder interests Upgraded ambition for growth The Board considered upgrades to the new and long-term ambitions for GSK, through investing for the future and delivering attractive returns to shareholders Progressive dividend policy The Board and Audit & Risk Committee considered the application of the progressive dividend policy in line with capital allocation priorities Capital allocation framework The Board considered an updated capital allocation framework to best support growth and sustainable returns to shareholders Business development The Science Committee considered the scientific merits of business development opportunities and where relevant for late stage assets commercial reviews, prior to the Board's review and approval In June 2021, GSK articulated to shareholders an outlook for the period to 2026 and 2031. Given GSK’s improved performance and strong momentum as a focused biopharma company, the Board and Audit & Risk Committee agreed that an update to investor expectations was appropriate In January 2024, following thorough review, GSK published new upgraded outlooks to the market for 2021-26 for sales to grow more than 7% and adjusted profit by more than 11% on a CAGR basis, and by 2031 to deliver sales of more than £38 billion. This represents an increase of £5 billion versus the estimate given in 2021 and a marked sales acceleration. This also provided clear visibility to shareholders, our people and other key stakeholders of the building blocks of future growth for the company The Board recognises the importance of dividends to shareholders. In December, the Audit & Risk Committee and the Board considered how GSK's progressive dividend policy should best be applied in line with the agreed capital allocation priorities of the Group and its investment strategy for growth alongside the sustainability of the dividend This resulted in an increased dividend of 16p for Q4 2023 (Q4 2022: 13.75p) and 58p for the full year 2023 (2022: 61.25p). The expected dividend for 2024 is 60p The Board approved an updated capital allocation framework, with the priority of investing in the business, focussed towards development of the pipeline through both the organic R&D portfolio, and targeted business development. This will be achieved through an increased focus on ROI for these investments Ultimately, the Board determined that the updated framework would continue to support investing in growth and delivering sustainable returns to shareholders, underpinned by a strong balance sheet. It is also consistent with GSK's strategic priorities and supports the company's commitment to deliver long-term profitable growth The Board, with support from the Science Committee and commercial reviews for late stage assets, reviewed many business development opportunities during the year. Those leading to concluded transactions included: – licence agreements with Hansoh Pharma for two antibody-drug conjugates with potential across several solid tumour indications to support our work in developing cancer treatments – agreement with Chongqing Zhifei Biological Products to co-promote Shingrix in China, which will significantly extend the availability of the vaccine and support patient access – acquisitions of BELLUS Health and Aiolos Bio to expand and strengthen GSK's respiratory portfolio These deals were considered in the context of their potential to help GSK deliver transformational medicines to patients and drive growth through accelerating the pipeline Stakeholder groups and other section 172 duties considered Stakeholders: Patients, employees and  investors Other s172 duties: Our long-term results, workforce, fairness between shareholders and business relationships Stakeholders: Investors, patients and our workforce Other s172 duties: Our long-term results, workforce and business relationships and reputation, and fairness between our shareholders Stakeholders: Patients, employees and  investors Other s172 duties: Our long-term results, workforce, fairness between shareholders and business relationships Stakeholders: Patients, employees and investors Other s172 duties: Our long-term results, workforce and business relationships 126 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Continuous engagement and key decisions continued Decision How the Board/Committee regarded stakeholder interests Artificial intelligence and workforce culture The Board considered the approach to and impact of adopting AI on an end-to- end basis across the business The Board reviewed and provided feedback on the strategy to integrate and responsibly scale AI across the business to accelerate the pipeline, amplify performance and drive productivity The Board recognises the significant potential of AI, particularly in the context of interpreting datasets to develop medicines with a higher probability of success. However, with support from the Audit & Risk Committee, the Board also considered the associated risks of AI, as described on pages 133 and 134. The Board approved the establishment of the AI Governance Council, co-chaired by the General Counsel and CDTO to help manage these risks across the Group Close attention was also paid to the impact of adopting AI on the workforce, including wellbeing gains enabled through increased efficiency and the benefits of further upskilling and building AI capabilities Stakeholder groups and other section 172 duties considered Stakeholders: Patients and employees Other s172 duties: Our long-term results, workforce and business relationships Low-carbon Ventolin strategy The Corporate Responsibility Committee and Board reviewed plans for progression to the next phase of development of the low- carbon Ventolin programme During the year, the Corporate Responsibility Committee endorsed and the Board reviewed and approved plans to progress the transition from a metered dose inhaler to new-generation low-carbon inhalers, to significantly contribute to GSK's carbon reduction targets for 2030 and 2045. Phase III trials will begin in 2024 and, if successful, the programme has the potential to reduce greenhouse gas emissions from use of the inhaler by approximately 90% Stakeholders: Patients, employees and investors Other s172 duties: Our long-term results, workforce and business relationships The Board and Corporate Responsibility Committee carefully considered the needs of patients who rely on Ventolin, the complexity of the clinical development process as well as the investment required in new manufacturing facilities. If successful, the programme could lead to regulatory submissions in 2025, supporting the health of asthma and COPD patients and making a significant positive impact on GSK's transition to a more environmentally sustainable future 127 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports Corporate Responsibility Committee report Dr Anne Beal Corporate Responsibility Committee I am pleased to present this report, which is my second as Chair of the Corporate Responsibility Committee (the Committee). This is the first full year for GSK operating as a global biopharma company, with a renewed purpose to unite science, technology and talent to get ahead of disease together. To deliver this purpose, the company needs to consider ESG impacts across everything it does. The Committee oversees the six ESG focus areas that address what is most material to the business and the issues that matter the most to stakeholders. As we worked through our programme of activities this year, my Committee’s focus was to ask management fundamental questions concerning: – how well the company is performing against and making an impact on the six ESG areas embedded in the company’s strategy – how this supports our sustainable performance and long- term growth – how further improvements can be identified and implemented To support this, we undertook a number of ESG performance deep-dives. Access The Committee reviewed progress towards the company’s aim to improve the health of 2.5 billion people by 2030 through ensuring access to our vaccines and medicines, including reaching 1.3 billion people in lower-middle income countries (L/LMICs). In particular, we discussed: – the flexible and tailored operating model to driving access in L/LMICs, depending on need – working with partners with the right capabilities and geographical footprint to deliver interventions, which may include donations, affordable supply and licensing, to make sure people have access to the vaccines and medicines they need – investing £1 billion over 10 years in our Global Health R&D pipeline and contributing to building resilient health systems Global Health & Security Anti-Microbial Resistance (AMR): The Committee reviewed the external AMR landscape and trends, which are a major threat globally, and considered the company’s holistic and innovative investment approach to addressing this AMR threat. We were pleased to note that this approach has resulted in the largest relevant AMR vaccine R&D pipeline in the industry. We discussed with management the steps needed to help leverage this leadership position, in conjunction with the support and expertise of the Science Committee. This included growing our business development strategy and improving pathogen surveillance capabilities. Given AMR is an urgent public threat and stakeholders are increasingly interested in GSK’s approach to it, we agreed that it was appropriate to include AMR as one of our ESG Performance Rating metrics for the first time. Environment Carbon reduction plan: There is a very strong case for making the transition to low-carbon inhalers. Salbutamol is an essential rescue/reliever medicine, and GSK's Ventolin (salbutamol) metered dose inhaler (MDI) is used by 35 million patients globally. Use of the inhaler, due to the high global warming potential (GWP) of the current propellent, accounts for half of GSK’s carbon footprint. Management updated the Committee about developing proposed plans to transition the inhaler to a next-generation low-carbon propellant which, if successful, will significantly contribute to GSK's carbon reduction targets for 2030 and 2045. However, developing this low-carbon inhaler is complex and involves clinical and non-clinical programmes, as well as establishing new manufacturing facilities. Having examined these and other key considerations behind investing in a low-carbon transition programme – which could reduce greenhouse gas emissions from the inhaler by 90% – we endorsed management’s R&D MDI transition programme investment case to the Board, submitted after the read-outs from latest early clinical data had been received and evaluated. This supported the Board’s decision in November to progress to phase III trials in 2024. If these trials are successful, they could lead to regulatory submissions in 2025. Nature plan review: The Committee received an update on current performance against the company’s Nature positive goal by 2030, which will be achieved by reducing the company’s environmental impacts across water, waste and materials, and biodiversity and by investing in protecting and restoring nature. The Committee was satisfied that these Nature goals and targets remain appropriate and industry leading. We also noted that standards for assessing and verifying companies' nature approach continued to strengthen. We were pleased that GSK was actively helping to shape this environment as a source of competitive advantage. Science Based Targets Network for Nature (SBTN) set the first science- based targets for a nature framework to validate companies’ nature targets, which was similar to the regulatory approach previously adopted for climate-based targets. Given the relative maturity of our Nature positive programme, the company is pleased to be selected in the first group of 17 companies globally to go through the target validation process, to accredit our nature targets when the SBTN methodology was finalised. Additionally, GSK has also committed to disclosing our arrangements against the Taskforce on Nature-related Financial Disclosures framework in our 2025 Annual Report. Diversity, Equity and Inclusion Delivery against People DEI aspiration: The Committee heard from the Chief People Officer (CPO) on progress over the company’s workstreams to drive increased leadership diversity, build a diverse talent pipeline and foster an inclusive culture. We were pleased with the excellent progress that had been made to date and discussed the challenges and opportunities to maintain future progress in these areas. 128 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Clinical trial diversity: The Chief Scientific Officer (CSO) outlined the approach to broadening clinical trial diversity and how this connects with our patient impact. The Committee strongly agreed that the company’s clinical trials must be accessible and inclusive to ensure our clinical development programmes reflect the diversity of the patient populations impacted by the disease under study including, but not limited to, age, race, ethnicity, sex and gender. In doing so, we noted the importance of reflecting epidemiological profile rather than census profile as the benchmark from which to plan appropriate patient representation and of working through community groups to build trust, awareness and participation in clinical trials. ESG Performance Rating The ESG Performance Rating (Rating) helps us integrate ESG into the delivery of our strategy and allows us to measure and verify the progress we are making. This is the second year that the Rating has been used and the Committee continues to oversee its evolution to make sure it meets the expectations of key stakeholders. We discussed with management the rationale for removing one of the ESG metrics relating to Access. We also scrutinised how the new AMR metric was formulated, reviewed, and set, to make sure that it was a suitably stretching and strategically relevant metric. We were joined by the CPO and CSO to discuss the status of the five DEI metrics and any other measures needed to progress performance against these metrics. Separately, the Committee was kept informed of the work being led by the CFO to assure the data underlying the ESG metrics and Rating which has been overseen by the Audit & Risk Committee. We monitored and evaluated the company’s progress against these metrics and the Rating at the half and full year. We then recommended to the Board publishing a final 'on track' ESG Performance Rating alongside the other ESG disclosures in this Annual Report and our ESG Performance Report. For more details, see page 46 of the Strategic report and in the ESG Performance Report – both of which are available at gsk.com. Dr Anne Beal Corporate Responsibility Committee Chair 27 February 2024 Science Committee report Dr Hal Dietz Science Committee I am pleased to present my first report as Chair of the Science Committee (the Committee) on our activities during 2023. I joined the Committee in January 2022, and succeeded Dr Jesse Goodman as Chair on 1 January 2023. Jesse had been Chair of the Committee since it was created seven years ago and made an outstanding contribution to defining and implementing the Committee’s role. He remains an important member of the Committee and offers vital insights to our work. The Committee’s key activities in 2023 were split into three important areas: – pipeline reviews: monitoring of GSK’s pipeline – business development: undertaking technical reviews and assurance of the underlying science of potential business development transactions – scientific deep-dives: discussing and analysing the key scientific and technology themes which drive the company’s R&D strategy Pipeline progress During 2023 the Committee continued to monitor the progress of R&D. Our CSO, Dr Tony Wood, provided regular updates on progress across the company’s four therapeutic areas: infectious diseases, HIV, respiratory/immunology and oncology. A particular pipeline highlight during 2023 was the launch of Arexvy, GSK’s world-first RSV vaccine for older adults. During the year, the vaccine gained approvals in the US, EU, Japan and several other countries. Arexvy marked a turning point in efforts to reduce the burden of the RSV, a respiratory virus which has evaded prevention or therapeutic advances for over 60 years. It also heralds the next wave of vaccine innovation at GSK. In oncology, Jemperli, in combination with chemotherapy, received approval in the US and EU as the first new frontline treatment option in decades for patients with dMMR/MSI-H primary advanced or recurrent endometrial cancer. These approvals reinforced the potential of Jemperli to redefine cancer treatment as the backbone of immuno-oncology therapy. A number of other key regulatory milestones were also achieved during the year: – Shingrix vaccine for shingles approved for people at risk over 18 in Japan and positive data from first efficacy trial in China – Apretude, a long-acting preventative treatment for HIV, approved as the first and only HIV prevention option in Europe – Ojjaara/Omjjara, approved in the US, EU and UK as the first and only treatment for both newly diagnosed and previously treated myelofibrosis patients with anaemia – gonorrhoea vaccine candidate received US FDA fast-track designation 129 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued The Committee was pleased with the progress made to accelerate the pipeline during the year, both in terms of investment in the late-stage pipeline to drive growth, as well as through rigorous decision-making with the early stage pipeline to maximise its potential impact on patients. R&D leadership changes Continuing to accelerate the pipeline relies on attracting the best people and fostering a culture that is ambitious for patients, accountable for impact and always does the right thing. That is why the Committee was pleased with the R&D leadership changes made this year, including creating three dedicated Research Units: vaccines and infectious diseases, respiratory and immunology, and oncology. HIV research operates as part of our global specialist HIV company, ViiV Healthcare. These changes mean the company can better focus on its core therapeutic areas and more easily identify the targets that will have the best outcomes for patients. Supporting these new teams is a single research technologies organisation, which brings together platform and data groups to integrate technology more effectively across GSK's workflow. Business development transactions Since the demerger, the CSO and his team have worked hard to accelerate business development to complement GSK’s organic pipeline. This called upon our Committee to devote nearly twice as much time in our meetings to critically vet business development proposals and transactions, compared with last year. Transactions reviewed by the Committee during the year include: BELLUS Health: the acquisition of BELLUS, a late-stage biopharmaceutical company working to better the lives of patients suffering from refractory chronic cough (RCC). The acquisition provided GSK with access to camlipixant, a potential best-in-class treatment in phase III development for the first-line treatment of RCC. This acquisition aligned to GSK’s expertise in and prioritisation of respiratory medicines. Hansoh Pharma: two exclusive licence agreements for antibody-drug conjugates: HS-20089, with best-in-class potential in ovarian and endometrial cancer and HS-20093, with promising initial clinical activity in lung cancer with the potential to address unmet medical need in broader solid tumour indications. Aiolos Bio: acquisition of Aiolos, which closed in February 2024, adds AIO-001 to GSK's respiratory biologics portfolio. AIO-001 is a phase II-ready long-acting antibody that could redefine the standard of care for asthma patients, with dosing every six months. It also has the potential to expand the company's reach to a broader range of asthma patients. Arrowhead Pharmaceuticals and Janssen Pharmaceuticals: the transfer of exclusive worldwide rights to further the development and commercialisation of an investigational therapeutic to treat chronic hepatitis B. GSK plans to evaluate this drug in a sequential regimen with bepirovirsen (GSK’s investigational antisense oligonucleotide) for the treatment of chronic hepatitis B. The transaction has the potential to redefine the treatment paradigm for chronic hepatitis B by enabling more patients to achieve functional cure. As a Committee, we are confident that these transactions have strong scientific justification and look forward to seeing them develop in the next few years. Deep-dives into innovative science During the year the Committee has continued to undertake scientific deep-dives into some of the highly innovative technologies currently being explored by the CSO and his team. Deep-dives undertaken in 2023 included, but were not limited to, both liver disease and oligonucleotide strategy. GSK’s expertise in infectious disease, immunology and human genetics has driven research into chronic hepatitis B. In 2023, new data presented for bepirovirsen has improved understanding of the heterogeneous nature of hepatitis B infections. Insights – from the B-Clear and B-Together phase IIb trials for bepirovirsen – will help GSK progress towards a comprehensive functional cure for people living with chronic hepatitis B, a common cause of chronic liver disease. Our deep-dive into oligonucleotide-based therapeutic strategies positions GSK to achieve leadership in this field. Oligonucleotides have a unique ability to address a wide range of genomic targets across many therapeutic areas, which means they offer enormous potential to help patients with diseases that have historically been difficult to treat. The company’s collaboration with Wave Life Sciences, initiated in 2022, brought together Wave’s PRISMTM platform and GSK’s expertise in genetics and genomics to progress up to eight preclinical programmes. The collaboration also granted GSK the exclusive licence for Wave’s preclinical programme to treat alpha-1 antitrypsin deficiency, complementing GSK’s own clinical-phase oligonucleotides, including bepirovirsen. Committee changes Since I became Chair, there have been no changes to the Committee’s composition during 2023. Work is underway by the Nominations & Corporate Governance Committee to refresh the Board’s scientific expertise including a successor to Dr Jesse Goodman, who is due to retire from the Board in 2025. I look forward to providing an update on this next year. Dr Hal Dietz Science Committee Chair 27 February 2024 130 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Nominations & Corporate Governance Committee report Jonathan Symonds Nominations & Corporate Governance Committee I am pleased to present my fifth report as Chair of the Nominations & Corporate Governance Committee (the Committee). Evolving the Board and pipeline of talent In my Corporate governance statement on page 114, I discussed the important Board appointment processes that have been undertaken recently. Julie Brown, our new CFO, was appointed in September 2022 and joined the Board in 2023. Wendy Becker, our new Remuneration Committee Chair designate, was appointed and joined the Board in the second half of 2023. A transition process is underway to enable Wendy to succeed Urs Rohner as Remuneration Committee Chair at the close of the 2024 AGM. These appointments are tailored to the biopharma company we now are. The Committee seeks to follow best practice in all the searches it makes and appointments it recommends to the Board, agreeing the criteria for each role, the most appropriate diverse interview panel and considering a comprehensive and diverse longlist of candidates. Shortlisted candidates are interviewed and assessed against the chosen criteria. Due diligence is then undertaken before the Committee makes its final recommendation. Executive search firms are appointed according to the company’s procurement policy and based on their expertise relative to each role. The Committee only engages search firms that are signatories to the Voluntary Code of Conduct of Executive Search Firms on gender diversity and best practice. The Committee worked with a number of executive search firms in 2023. They also provided additional consultancy services to the company: Korn Ferry (general recruitment, executive search and assessment services and other HR-related services); Egon Zehnder (executive search, assessment and coaching services to specific senior executives); Russell Reynolds (executive search services). The Committee reviewed the potential for conflicts of interest and judged that there were appropriate safeguards against such conflicts. I look forward to reporting on the Committee's continued work and progress to evolve the Board further in next year's report. The Committee also continues to review our diverse talent and succession pipelines and the development plans for key management roles and their successors. During the year, we undertook a deep-dive of the emerging senior talent that the GLT had identified – people who were exceeding expectations or exceptionally talented, and who have the potential to take on a GLT role in the future. This included reviewing the strategic approach to talent development planning. The Board seeks to meet with these individuals at employee receptions and through other Board engagement opportunities. Board and GLT diversity We are committed to the diversity of our Board and its committees, just as GSK is committed to equal opportunities for all employees at every level of the company. The Board and management seek to support and encourage a diverse and inclusive culture throughout the company. An effective Board includes a range and balance of skills, experience and knowledge as well as diversity of ethnicity, gender, sexual orientation, professional and social-economic background, disability, age and independence, with individuals who are prepared to challenge each other collaboratively. This mix is complemented by a diversity of personal Board attributes, including character, intellect, judgement, honesty and courage. The Committee is responsible for developing measurable objectives, in line with the relevant regulatory and best practice targets, and monitoring their progress – which is part of implementing the Board’s diversity policy (Policy). This includes gender and ethnicity diversity targets, and applying it to our Board committees. As a minimum, we seek to align our Policy objectives with the Financial Conduct Authority (FCA), FTSE Women Leaders Review and Parker Review diversity targets (Regulatory and Best Practice Targets) and ensure that they are consistent with our public DEI aspirations. We currently meet or exceed our policy objectives and the Regulatory and Best Practice Targets shown on the next page. Board and GLT diversity data collection This year, diversity data has been gathered directly on a self- identified basis as follows: – Board members: using a questionnaire – GLT members: individual election held on GSK's HR database All diversity data published in the following section of the report are as at 31 December 2023 and the date of publication. We also continue to oversee the developing pipeline of direct reports to the GLT by gender and from ethnically diverse backgrounds. Full details of GSK’s representation of women and ethnically diverse leaders is covered on page 53, as part of the diversity of our global workforce. The pleasing progress against our DEI commitments, including gender and ethnicity, is illustrated in our ESG Performance Report on gsk.com. This good progress has been boosted since introducing a DEI measure in 2022 as part of the Annual bonus arrangements for our Executive Directors and other GLT members. Sir Jonathan Symonds Nominations & Corporate Governance Committee Chair 27 February 2024 131 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Diversity, equity and inclusion Ethnicity Gender % female composition1 l Ethnically diverse: 17% l White: 83% l Current/historic l Expected (1) Target female representation on the Board is 40%. Data from the GSK Annual Report published in the first quarter of each year. Current female representation is 42% and includes one of the very few all-female Executive Boards running a FTSE 100 company. This is expected to rise to 45% in May 2024, after Urs Rohner retires from the Board Board and GLT diversity objectives At least: – 40% of Board positions held by women Status of objective Performance Met 42% – one woman in a senior Board position (CEO, CFO, SID and/or Chair) by the end of 2025 Exceeded – 40% of GLT positions held by women – one Board Director is ethnically diverse – one GLT member ethnically diverse by the end of 2025 FCA UK Listing Rule diversity reporting Exceeded Exceeded Met Two Directors (CEO and CFO) 50% Two Directors One GLT member Gender identity or sex Men Women Not specified/preferred not to say Ethnic background White British or other White (including minority white groups) Mixed/Multiple Ethnic Groups Asian/Asian British Black/African/Caribbean/Black British Other ethnic group, including Arab Not specified/preferred not to say Number of Board members Percentage of the Board Number of senior positions on the Board (CEO, CFO, SID and Chair) Number in Executive Management Percentage of executive management 7 5 — 10 — 1 1 — — 58% 42% — 83.3% — 8.3% 8.3% — — 2 2 — 4 — — — — — 6 6 — 50 % 50 % — 10 83.3% — 1 — — 1 — 8.3% — — 8.3% 132 20202021202220232024 (current)2024 (post-AGM)01020304050 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Audit & Risk Committee report Technology Charles Bancroft Audit & Risk Committee I am pleased to present this report, which is my third as Chair of the Audit & Risk Committee (the Committee), and in the following pages I aim to share insights into the activities undertaken or overseen by the Committee during the year. 2023 was GSK’s first full year as a focused global biopharma company. The Committee reviewed key operational features and risks of the governance platform that underpin our purpose to unite science, technology and talent to get ahead of disease together. I am also pleased to report on progress against the Committee's expanded remit to oversee and review ESG data assurance. This Committee continues to have primary oversight for the Zantac litigation through regular legally privileged updates and review of the related accounting, disclosure and communication requirements. The Committee also reviews the current indicative timeline of cases. I report and summarise the key matters for the Board for its awareness, input or decision. We continue to defend all claims brought vigorously based on the science. Based on the work the Committee has done or inspected, GSK continues to exhibit a strong compliance culture, with a consistent tone and engagement from the top that runs throughout the organisation. Our financial reporting and controls framework remains robust and required no fundamental changes during the year. Science Strategic vaccine partnership in China: In Q3 2023, the company entered into an exclusive agreement with Chongqing Zhifei Biological Products, Ltd (Zhifei) to co-promote Shingrix in China to support accelerated market penetration for our innovative vaccine. The Committee scrutinised this arrangement before it was concluded. A significant amount of time and resources were devoted to due diligence of this arrangement, and key controls were introduced to ensure our compliance expectations would be met to mitigate risks. The Committee was satisfied that the ongoing governance framework – with monthly reviews and monitoring arrangements – was appropriate. Experienced compliance personnel were also allocated to support the partnership. Chief Patient Officer: A new role of Chief Patient Officer was established from the beginning of 2024. The Committee assessed the controls and governance arrangements for this new role. The Chief Patient Officer's primary role is to provide medical leadership as part of one overarching GSK asset and disease strategy. The Chief Patient Officer reports to the Chief Commercial Officer to ensure patients treated with GSK products benefit from robust, compliant scientific information, in line with our commitment to patients. We also satisfied ourselves that key areas of medical ethics, safety and execution of clinical trials have clear lines of escalation to our Chief Medical Officer. This further enhanced the company’s Internal Control Framework and Independent Business Monitoring protocols. Data privacy and ethics: This is a rapidly evolving principal risk for the Committee’s oversight. The number of privacy laws and regulations, often based on the EU General Data Protection Regulations, is increasing in a number of territories around the world. Consequently, the Committee was interested to further understand the regulatory approaches being adopted in some of our biggest markets, including the US, India and China, and how they may affect GSK’s operations, including our R&D operations. The Committee receives regular reports on the robust and integrated governance framework GSK operates to monitor and govern the use of data generally. GSK's framework is made up of specialist governance boards that include representative members from relevant internal functions. This framework has been further augmented with a team from the Legal and Compliance function with expertise to advise on global digital, privacy and cyber security matters. The Committee discussed the tenets of the new enhanced flexible data privacy model being introduced. This is expected to comprise global privacy principles and standardised global controls meeting the EU standards. The reward would be flexibility to adopt different standards where local laws are incompatible with GSK's standardised global controls, provided they meet GSK's global privacy principles. More details of the measures taken during the year to mitigate this risk are described on page 60. Information and cyber security: This is a principal risk for GSK and an area that remains a standing agenda item which is discussed at each of our scheduled meetings. The Chief Digital and Technology Officer (CDTO), Chief Information and Security Officer (CISO) and Chief Compliance Officer (CCO) present updates on information and cyber security, as well as assessments of the status of their associated key risk indicators. The CDTO’s skills and experience, especially those related to cyber security, are set out on page 112. Our CISO has spent his career building and leading technology teams across several functional areas, including cyber security and IT infrastructure for digital communications and healthcare companies. He was also responsible for establishing the cyber security function for Haleon plc prior to its demerger. Our CCO focuses on ensuring that a consistent and cohesive approach to information and cyber security operates across all aspects of the business and enterprise risk management. The CCO is also responsible for the Risk Analytics and Monitoring organisation. He has previous experience in creating a dedicated Global Risk Office that combines enterprise risk management and reporting activities for GSK. During the year, the Committee reviewed progress against the first full year of our updated multi-year Cyber Security Plan (Plan) which was benchmarked against the National Institute of Standards and Technology Cyber Security Framework (NIST- CSF). At the end of 2023, to help validate how the company’s capabilities had improved, the Committee examined the results of an internal NIST assessment that was undertaken jointly by our Tech and Audit & Assurance functions. In 2024, building on this assessment, the Committee will review the scheduled external NIST review by specialist independent cyber experts. I look forward to providing an update on the results of this independent review in my report next year. 133 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued The Committee has also been closely following the development, finalisation and introduction of the Securities and Exchange Commission’s (SEC) new cyber security rules (Rules) effective from the end of 2023. We are satisfied that the company, as a foreign private issuer, has taken the necessary governance steps to ensure compliance with these requirements. The Committee assesses the adequacy of GSK's insurance risk coverage arrangements annually, including the information and cyber security risk, as part of its insurance risk programme review. I then communicate the Committee’s recommendation to the Board before implementation. Also on our agenda was cyber security training for GLT – which included cyber security simulation exercises and learnings – and for the wider workforce. We discussed mandatory training for new joiners and regular phishing-simulation exercises. I highlighted previously the relevant cyber security expertise my Board colleague, Dr Vishal Sikka, brings to our deliberations. We are looking to further strengthen our oversight in this area by running bespoke cyber incident training sessions for all Directors. Their cyber-related experience is included in the Board biographies on pages 108 to 111. Further details of the other measures taken during the year to mitigate this risk are described on page 60. Artificial Intelligence (AI): The rapid advancement of AI, in particular generative technology and its potential application across the company, presents significant opportunities to drive innovation, growth and productivity and, in doing so, to accelerate our purpose. To this end, the Board is reviewing opportunities to scale use of AI for potential competitive advantage. Balanced against this is the awareness that there is a lack of harmonisation from new and emerging regulations that govern ethical and responsible use of AI. These new trends may impact the risk profile of our Research practices, Scientific and patient engagement, Data ethics and privacy, and Information and cyber security principal risks, and could have a future impact on GSK’s value chain. Therefore, these developments were being monitored very closely by management and the Committee. To this end, the Board approved the establishment of the AI Governance Council (Council), co-chaired by the General Counsel and CDTO and comprising cross-functional experts. In particular, the Council is assessing business activities against the current risk environment through our internal control framework. Importantly, the Council is fully connected to the key data management boards for data ethics and privacy and information and cyber security. I am pleased to report that the Council has approved and implemented a suite of written standards, controls for adopting new AI tools, and training tailored for developers, procurers and users of AI. The Committee and our auditor have a shared goal to leverage technology as appropriate. We were particularly interested in and discussed with the auditor how they can use AI to deliver increased effectiveness and efficiency in their audit. We are also keen to better understand the opportunities for GSK to use scalable AI-enabled innovations to improve the speed and performance of its tracking and detection capabilities. This is a key part of staying ahead of the increasingly sophisticated threats to the Group and our third parties. This will be an area we continue to focus on. ESG data assurance The Committee oversaw the creation and implementation in Q3 2023 of a new dedicated ESG data assurance hub in our Finance organisation. This formally established a consistent approach to governance, processes and controls which have been developed to further improve assurance of ESG data in support of the company’s performance against key ESG metrics. Meanwhile, our Corporate Responsibility Committee, on behalf of the Board, continues to oversee ESG strategy, performance assessment and reporting. The hub's initial focus is on environmental data. Later, as its processes and capabilities develop, the hub will look at social and governance areas too. Soon the Committee will also oversee the development and implementation of technology solutions to automate information gathering and to supplement the level of process and control standards that surround ESG performance data. Looking forward, the Committee will continue to review upcoming regulations that might affect our future ESG assurance and reporting obligations, which have been highlighted by the hub’s horizon-scanning activities. In particular, the Committee discussed the initial results of the ongoing impact assessment that is underway for the Corporate Sustainability Reporting Directive. This directive could become partially effective from our 2025 reporting year, and would be fully effective at a consolidated reporting level for GSK by 2028. We are also aware that reporting arrangements to reflect the published SEC Climate regulations are expected to become effective from the 2026 financial year. Internal control framework The Board recognises its obligation to present a fair, balanced and understandable assessment of GSK’s current position and prospects. It is accountable for evaluating and approving the effectiveness of GSK’s internal controls, including financial, operational and compliance controls, and risk management processes. We ensure the reliability of our financial reporting, and compliance with laws and regulations, through our internal control framework. This is a comprehensive enterprise-wide risk management model, which supports the Board to identify, evaluate and manage the Group’s principal and emerging risks, as required by the FRC’s Code. The framework is designed to manage the risk of GSK not achieving its business objectives. A fit-for-purpose framework – complemented by our corporate culture and Speak Up processes – ensures that the risks associated with our business activities are actively and effectively controlled in line with our agreed risk appetite. We believe GSK’s framework provides reasonable, but not absolute, assurance against material misstatement or loss. The Board mandates the Group’s Risk Oversight and Compliance Council (ROCC) of senior leaders to support the Committee in overseeing risk management and internal control activities. It also provides the business with a framework for risk management and escalation of significant risks. Risk management and compliance boards (RMCBs) across the Group promote the ‘tone from the top’ and establish our risk culture, and ensure effective oversight of internal controls and risk management processes. 134 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Each principal risk has an assigned risk owner, drawn from senior management, who is accountable for managing the principal risk with oversight from a GLT member, which includes setting and implementing risk mitigation plans. Risk owners report quarterly on their respective risk management approach and progress at the ROCC and the appropriate Board committee. Our Compliance function assists the ROCC and RMCBs. Compliance is responsible for advancing enterprise- wide risk management and for developing risk-based and ethically sound working practices. It also actively promotes ethical behaviours by enabling all employees to operate in line with our culture and comply with applicable laws and regulations. Our Audit & Assurance (A&A) function provides independent assurance to senior management and the Board on the effectiveness of risk management Group-wide, in line with an agreed assurance plan. This helps senior management and the Board to meet their oversight and advisory responsibilities to fulfil GSK’s strategic objectives and build trust with patients and other stakeholders. A&A has a dual reporting line to the CFO and the Committee. As a Committee we receive regular reports from principal risk owners, Compliance and A&A on areas of significant risk to the Group and on related internal controls. These reports assess the internal control environment within each principal risk area, including enhancements to strengthen controls. Once we have considered these reports, the Committee reports annually to the Board on the effectiveness of GSK’s internal controls. In 2023, through the authority delegated to the Committee, the Board conducted a robust assessment of the Group’s principal risks. This assessment in line with the FRC’s Code included consideration of the nature and extent of risk the Board is willing to take to achieve GSK’s strategic objectives. The Board, via the Committee, also oversaw the effectiveness of our internal control environment and risk management processes across the Group for the whole year, up to the approval date of this Annual Report. More detail about the review of the Group’s risk management approach is further discussed in the Risk management section of the strategic report on pages 57 to 76. The management of each principal risk is explained in ‘Principal risks and uncertainties’ on pages 284 to 294. The Group’s viability is discussed in the Strategic report on page 76. 135 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Significant issues relating to the financial statements In considering GSK’s quarterly financial results announcements and the financial results in the 2023 Annual Report, the Committee reviewed the significant issues and management judgements in determining those results. It reviewed management papers setting out the key areas of risk, actions taken to quantify the effects of the relevant issues, and judgements made by management on the appropriate accounting required to address those issues in the financial statements. The significant issues considered in relation to the financial statements for the year ended 31 December 2023 are set out in the following table, with a summary of the financial outcomes where appropriate. The Committee and the external auditor have discussed the significant issues addressed by the Committee during the year and the areas of particular audit focus, as described in the Independent Auditor’s Report on pages 166 to 179. Significant issues considered by the Committee in relation to the financial statements Going concern basis for the preparation of the financial statements Revenue recognition, including returns and rebates (RAR) accruals Provisions for legal matters, including investigations into the Group’s commercial practices Provisions for uncertain tax positions Impairments of intangible assets Valuation of contingent consideration in relation to ViiV Healthcare ViiV Healthcare put option How the issue was addressed by the Committee The Committee considered the outcome of management’s half-yearly and year-end reviews of current and forecast net debt positions and the various financing facilities and options available to the Group. The Committee also considered management’s review of the impacts of both the current economic environment and climate change. Following consideration of these assessments, which included stress testing and viability scenarios, sources of liquidity and funding, forecasts and estimates, the Committee confirmed that the application of the going concern basis for the preparation of the financial statements continued to be appropriate. The Committee reviewed management’s approach to the timing of recognition of revenue and accruals for customer returns and rebates. The RAR accrual for US Commercial Operations was £6 billion at 31 December 2023 and the Committee reviewed the basis on which the accrual had been made and concurred with management’s judgements on the amounts involved. A fuller description of the process operated in US Commercial Operations in determining the level of accrual necessary is set out in ‘Critical accounting policies’ on pages 191 and 192. The Committee received detailed reports on actual and potential litigation from both internal and external legal counsel including the Zantac litigation, together with a number of detailed updates on investigations into the Group’s commercial practices. Management outlined the levels of provision and corresponding disclosure considered necessary in respect of potential adverse litigation outcomes and also those areas where it was not yet possible to determine if a provision was necessary, or its amount. At 31 December 2023, the provision for legal matters was £0.3 billion; see Note 32 to the financial statements, ‘Other provisions’ for more details. The Committee considered current tax disputes and areas of potential risk and concurred with management’s judgement on the levels of tax contingencies required. At 31 December 2023, a tax payable liability of £0.6 billion, including provisions for uncertain tax positions, was recognised on the Group’s balance sheet. The Committee reviewed management’s process for reviewing and testing goodwill and other intangible assets for potential impairment. The Committee accepted management’s judgements on the intangible assets that required writing down and the resulting impairment losses of £421 million in 2023. See Note 20 to the financial statements, ‘Other intangible assets’ for more details. The Committee considered management’s judgement that it was necessary to increase the liability to pay contingent consideration primarily as a result of updated exchange rate assumptions as well as increases in sales forecasts and the unwind of the discount. After cash payments of nearly £1.1 billion in the year, at 31 December 2023, the Group's balance sheet included a contingent consideration liability of £5.7 billion in relation to ViiV Healthcare. See Note 33 to the financial statements, ‘Contingent consideration liabilities’ for more details. The Committee reviewed and agreed the accounting for the Pfizer put option and concurred with management’s judgement on the valuation of the put option of £0.8 billion at 31 December 2023. 136 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Effectiveness and quality of external audit process The Committee is committed to making sure that GSK receives a high-quality and effective external audit. In evaluating Deloitte’s performance during 2022, prior to making a recommendation on its reappointment in early 2023, the Committee reviewed the effectiveness of its performance against the criteria which it agreed with management at the beginning of 2022. The detailed criteria used to judge Deloitte's effectiveness as external auditor are available at gsk.com. These are based on the audit approach and strategy, ensuring a high-quality independent audit, effective partnership and value for money. The Committee monitors engagements with external stakeholders relevant to our areas of oversight, including the FRC and Securities and Exchange Commission. We sought to ensure that Deloitte would deliver a smooth, thorough and efficiently executed audit for 2023 and so considered: – the overall quality of the audit – the independence of Deloitte – whether Deloitte showed an appropriate level of challenge and scepticism in its work Deloitte’s length of tenure was not taken into account when assessing its independence and objectivity, given it only commenced its role as auditor in 2018. However, the Committee did consider how effectively it had assumed its role as auditor. The Committee also considered feedback on the 2023 external audit, through a survey of Committee members and the financial management team at corporate and business unit level. The survey covered the: – effectiveness of the auditor’s challenge – integrity of Deloitte – transparency of its reporting to management and the Committee – the auditor's effective use of technology – clarity of the auditor’s communications and ways of working – quality of the audit team’s leadership – skills and experience of the audit team As Committee Chair, I regularly meet independently with the audit partner. We also meet with the auditor privately at the end of each Committee meeting to discuss progress, as appropriate. Having reviewed the above feedback, and noted any areas of improvement to be implemented by the audit team for 2024, the Committee was satisfied with the: – effectiveness of the auditor and the external audit process – auditor’s independence, qualifications, objectivity, expertise and resources We agreed to recommend to the Board Deloitte's reappointment at the next AGM, and did so free from the influence of any third party. Auditor’s reappointment External auditor External auditor appointment Last tender Transition year First shareholder approval of current auditor May–December 2016 2017 May 2018 First audited Annual Report and 20-F Year ending 31 December 2018 New lead audit engagement partner 2023 Next audit tender required by regulations 2025/2026 (to take effect from 2028) There were no contractual or similar obligations restricting the Group’s choice of external auditor. Audit partner rotation The external auditor is required to rotate the audit engagement partner for GSK every five years. Our previous audit partner stepped down in March 2023 after the audit of GSK’s financial statements for 2022 was concluded. After a robust review process by the Committee, together with the former CFO, the new audit partner was selected. The Committee approved the appointment with effect from the start of the 2023 financial year. We were satisfied that Deloitte managed an orderly handover to the new audit engagement partner. This resulted in a seamless transition and maintenance of high levels of audit quality and effectiveness throughout the reporting year. Audit tender The Committee considers that, during 2023, the company complied with the mandatory audit processes and audit committee responsibility provisions of the Competition and Markets Authority Statutory Audit Services Order 2014. As Deloitte continues to maintain its independence and objectivity, and the Committee remains satisfied with its performance, GSK does not intend to tender the external auditor contract before the end of the current required period of 10 years identified above and considers that this is in the best interests of shareholders. The Committee was mindful that there were appointments of a new CFO for GSK and audit partner for Deloitte during the 2023 financial year, which is helpful in further mitigating the risks of any over-familiarity between the company and the auditor. 137 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Board committee reports continued Non-audit services Audit and other services comparison (£m) Management operates on the presumption that other accountancy firms will ordinarily provide non-audit services to GSK. However, where the external auditor’s skills and experience make it the only suitable supplier of non-audit support – such as for audit-related matters, tax and other services – it may be used, in the best interests of the company. In line with GSK’s non-audit services policy, the Committee ensures that auditor objectivity and independence are safeguarded by reviewing and pre-approving the external auditor’s provision of such services. The company policy complies with the FRC’s 2019 Revised Ethical Standard and the Sarbanes-Oxley Act of 2002. It observes the following core policy features on engaging the external auditor for non-audit services: GSK non-audit services policy, key features: Process: Safeguards: Fee cap: All non-audit services over £50,000 are put to competitive tender with other financial services providers, in line with the Group’s procurement process, unless the skills and experience of the external auditor make it the only suitable supplier. Adequate safeguards are established so that the objectivity and independence of the Group audit are not threatened or compromised. The total fee payable for non-audit services should not exceed 50% of the annual audit fee, except in special circumstances where there would be a clear advantage in the auditor undertaking the additional work. Prohibitions: GSK’s policy includes a ‘whitelist’ of permitted non-audit services in line with the relevant regulations. Any service not on this list is prohibited. Pre-approval: All non-audit services require pre-approval as set out in the table below to ensure services approved are consistent with GSK’s non-audit policy for permissible services. This process ensures all services fall within the scope of services permitted and pre-approved by the Committee and does not represent a delegation of authority for pre-approval. Value More than £50,000 Pre-approver Committee Chair and CFO Between £25,000 and £50,000 Under £25,000 Group Financial Controller Designate of the Group Financial Controller l Audit services l Other Assurance services Further fees payable to Deloitte for non-audit services relating to the Consumer Healthcare demerger were £4.4 million in 2022 and £2.4 million in 2021, as set out on page 115 of the 2021 Annual Report and page 128 of the 2022 Annual Report respectively. A fee of £0.2 million was paid to the auditor in respect of GSK pension schemes in each of 2021, 2022 and 2023 The fees paid to the company's auditor and its associates are set out above. Further details are given in Note 8 to the financial statements, ‘Operating profit’ on page 198. The Committee considered the level of non-audit services incurred as part of its annual review of Deloitte’s independence set out on the previous page and was satisfied that the auditor continued to be independent and exercised objectivity throughout 2023. Fair, balanced and understandable assessment The need for an annual report to be fair, balanced and understandable is one of the key compliance requirements for a company’s financial statements. To ensure that GSK’s Annual Report meets this requirement, we have a well-established and documented process governing the coordination and review of Group-wide contributions to the publication. This runs in parallel with the process followed by the external auditor. The Committee received a summary of management’s approach to GSK’s 2023 Annual Report to ensure it met the requirements of the FRC’s Code. This enabled the Committee, and the Board, to confirm that GSK’s 2023 Annual Report as a whole is fair, balanced and understandable and provides the necessary information for shareholders to assess the company’s position and performance, business model and strategy. Code of Conduct and reporting lines We have a number of well-established policies (including a new Code of Conduct), which are available on gsk.com, together with details of our confidential Speak Up lines for reporting and investigating unlawful conduct. Charles Bancroft Audit & Risk Committee Chair 27 February 2024 138 1.66.34.020.420.627.72023202220210102030Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Remuneration report Committee Chair's annual statement Dear Shareholder, On behalf of the Remuneration Committee, I am pleased to present our Remuneration Report for 2023. This includes my Annual Statement, explaining the Committee’s work this year and our Annual Report on remuneration for 2023. A summary of our Remuneration Policy, which was approved by shareholders at the 2022 AGM, is available on pages 158 to 162 of the 2022 Annual Report and at gsk.com. Context for 2023 remuneration and outcomes As outlined earlier in this report, GSK delivered very strong performance in 2023, with sales, adjusted operating profit and adjusted EPS all growing at double-digit levels for the year (excluding COVID-19 solutions). There was also strong pipeline progress with four major product approvals, including the world's first RSV vaccine, Arexvy. Overall, the company is delivering the step change in performance in the commitments it has previously made to shareholders. 2023 was the second year of operation of the company's new Remuneration policy. This is a fundamental part of the architecture of GSK post-separation to ensure we build a performance culture and generate sustained delivery of shareholder value. Our policy better links executive remuneration to delivery of outperformance, with the Annual Bonus opportunity significantly reduced for below target performance, and increased for exceptional outperformance. Under the new scheme, the increase in the Bonus opportunity does not increase the potential cash reward for executives, as any incremental award is delivered in the form of shares, deferred for three years. 2023 Annual Bonus It is against this delivery that the Committee reviewed the Bonus outcomes for the CEO and CFO. In terms of the two financial measures, the company delivered sales growth of 14% and adjusted operating profit growth of 16% (excluding COVID-19 solutions). This was significantly higher than both the guidance the company provided at the start of the year and market expectations, and strongly supports delivery of GSK’s growth outlooks for the period 2021-26. This very strong performance led to an overall payout under the financial elements of the Bonus of 190% of salary. The 2023 targets were set after consideration of analyst consensus, and the Committee is comfortable that the payout is representative of very strong performance. The Committee also reviewed performance against the non- financial measures previously disclosed, together with executives’ delivery against their specific individual strategic and operational measures. When this performance was combined the overall payout against a maximum of 300% was 288% of salary for the CEO (of which 188% of salary is delivered in deferred shares) and 264% of salary for the CFO (197.5% of salary, after proration for the period she was employed in 2023; of which 99% of salary is delivered in deferred shares). Long-term incentive (LTI) awards 69.95% of the grant under the 2021 Performance Share Plan (PSP) award vested based on performance to the end of 2023. The award vested in three out of four measures. There was full vesting of the Pipeline Progress measure and almost full vesting under our Innovation Sales measure (20% and 19.95% respectively). The Cash Flow measure also vested in full (30%). We remain disappointed that we have not yet achieved vesting under our Relative TSR measure. In part this reflects the adverse share price reaction to Zantac litigation in the period, but we also recognise there have been relative concerns on the strength of the company’s pipeline. We are confident that the progress we are making to develop our portfolio, together with our improving longer-term outlooks for growth, will be increasingly reflected in GSK’s valuation. Summary of incentive outcomes Following a review of contextual factors including previous payouts, the Committee believes that the outcomes appropriately reflect performance in the round having considered the experience of all stakeholders including shareholders and our employees. The incentive awards in relation to 2023 were all made in accordance with the 2022 Remuneration policy. I also confirm that following careful review the Committee did not deem it necessary to exercise discretion. Remuneration policy implementation for 2024 Annual Bonus and LTI The Committee has determined that no changes will be made to our Bonus and LTI measures for 2024. The total sales growth and adjusted operating profit growth targets exclude the commercial benefit from COVID-19 solutions. Annual Bonus measures will continue to be based on: – annual total sales growth (30%) – annual adjusted operating profit growth (30%) – personal performance against strategic and operational measures (30%) – ESG: diversity, equity and inclusion (DEI) (10%) PSP measures will remain as: – relative TSR (30%) – total sales growth over three years (20%) – adjusted operating profit growth over three years (20%) – pipeline progress (20%) – ESG: environment composite scorecard (10%) The performance targets were also calibrated to consider a number of internal and external reference points, in particular analyst consensus. These were used to challenge the metrics and with input from our Science and Corporate Responsibility committees where relevant. The Committee is therefore satisfied that the targets set for 2024 are suitably stretching. Salary The Committee noted that a 4% increase has been agreed for the wider workforce in the UK. After careful consideration, including a review of the market and the CEO and CFO’s competitive positioning, it was agreed that they should each receive salary increases of 4% for 2024. 139 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Thank you I would like to take this opportunity to thank both my fellow Committee members and shareholders for your support and engagement during my tenure as Committee Chair. I welcome all further feedback and look forward to receiving your support for this report at our Annual General Meeting on 8 May 2024. Urs Rohner Remuneration Committee Chair 27 February 2024 Committee Chair's annual statement continued Workforce fairness In setting executive pay it is important that the Committee does so with a good understanding of the Group’s wider workforce approach to pay, with an emphasis on fairness and equity. To that end, on an annual basis, I meet with senior Human Resources Leaders from across the company to understand their perspectives on pay and GSK’s remuneration arrangements for the wider workforce globally. This year was the fifth such annual meeting held. Details of this important check are given on page 122. Board changes As announced in September 2022, Julie Brown joined the Board on 1 May 2023 as CFO, at which point Iain Mackay stepped down from the Board. Details of the joining and leaving arrangements for this transition were described in last year’s report. Remuneration Committee Chair succession Finally, I will be retiring as a Non-Executive Director of GSK at the 2024 AGM and this will therefore be my final report as Chair of the Committee. I was delighted to welcome Wendy Becker, who joined the Committee on 1 October 2023. Since then, Wendy and I have been working on a smooth transition and handover before she succeeds me as Committee Chair in May 2024. She has a wealth of experience chairing remuneration committees and is looking forward to chairing the Committee and leading our 2025 Policy review. The Committee is planning to undertake a review of the effectiveness of our remuneration arrangements in advance of the scheduled Policy renewal at the 2025 AGM. Wendy and Jonathan Symonds, our Chair, are looking forward to engaging with investors to ensure we are clear on your perspectives as we work to update our Remuneration policy. 140 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Remuneration at a glance 2023 Total Remuneration Emma Walmsley, CEO Julie Brown, CFO (from 1 May 2023)(1) 2023 Pay for performance 2023 Annual bonus outcome Financial measures Total sales growth* Target 7.0% Adjusted operating profit growth* 11.0% Delivered 13.9% 16.4% Non-Financial measures Overall Strategic and Operational measures ESG DEI Emma Walmsley Exceeded Met in full Julie Brown Exceeded Met in full 2023 Annual bonus delivery CEO Overall bonus 288% of salary CFO(1) Overall bonus 197.5% of salary (1)For service from employment on 3 April 2023 l Shares deferred for 3 years l Cash 2021 PSP outcome Relative TSR 0% of 30% Overall vesting 69.95% (1) See details of CFO joining arrangements on page 142 l Fixed pay – salary, benefits, pensions and other l Performance pay – annual bonus and vested LTIs l Vested l Lapsed 2024 Remuneration implementation Base salary 4% increase for UK employees and Executive Directors Benefits and pensions No changes Pay for Performance Bonus and LTI measures remain as follows Alignment to strategy Total sales growth* In line with sales growth ambitions Adjusted operating profit growth* In line with adjusted operating profit growth ambitions Strategic and operational Individual accountability for delivery of our strategy and public ambitions Pipeline Emphasis on Innovation – rewards acceleration and strengthening of pipeline Relative total shareholder return Alignment with shareholders ESG ambitions Nature and Climate ambitions 2024 – DEI Priorities *excluding COVID-19 solutions Annual bonus 30% 30% 30% – – – 10% LTIs (PSP) 20% 20% – 20% 30% 10% – 141 20232022£0m£2m£4m£6m£8m£10m£12m£14m2023£0m£2m£4m£6m£8m65%35%50%50%Adjusted freecash flow 30% of 30%Innovation sales 19.95% of 20%Pipeline progress 20% of 20% Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration 2023 Total remuneration (audited) Fixed pay Salary Pension Benefits Read more on page 143 Pay for performance + Annual Bonus + LTI awards (2021 PSP award vesting) = Total remuneration pages 144 and 145 pages 146 and 147 below The following sections from this page to page 160 provide details of each element of 2023 ‘Total remuneration’ and how the Committee implemented the company’s shareholder-approved 2022 Remuneration policy during the year in terms of fixed and performance pay. 2023 Total remuneration (audited) Emma Walmsley, CEO Julie Brown, CFO (from 1 May 2023) Iain Mackay, former CFO (to 1 May 2023) Fixed pay Salary Benefits Pension Other(1) Total fixed pay Pay for performance Annual bonus(2) (3) Vesting of PSP LTI awards(4) (5) (6) Total pay for performance 2023 £000 1,310 212 94 — 1,616 3,774 7,328 11,102 2022 £000 1,260 131 253 — 1,644 3,143 3,662 6,805 2023 £000 635 50 44 2,411 3,140 1,687 — 1,687 Total remuneration 12,718 8,449 4,827 2022 £000 — — — — — — — — — 2023 £000 305 82 22 — 409 728 5,294 6,022 2022 £000 915 291 183 — 1,389 2,082 1,854 3,936 6,431 5,325 (1) Other: Represents the sum paid to Julie Brown, the CFO, as part of her Buyout arrangements in relation to leaving Burberry, as set out in full on page 149 of the 2022 Annual Report. In setting the Buyout arrangements, which are staged over a two year period, the Committee sought to ensure she was compensated on a like-for-like basis as far as possible. In fulfilment of these arrangements, the CFO purchased 22,500 shares in June 2023 (2) Deferred Annual Bonus Plan (DABP): The mandatory DABP bonus deferrals for 2022 and 2023 are set out on page 156 (3) Annual bonus: The 2023 bonus payment for Iain Mackay represents bonus earned in respect of the period from 1 January to 1 May 2023. Details of the bonus paid in respect of the remainder of the year can be found in the Leaving Directors section on page 154. The 2023 bonus payment for Julie Brown represents bonus earned in respect of the period from 1 May to 31 December 2023. Bonus for the full period of her employment in 2023 is shown on page 144 (4) 2020 PSP vesting in 2023: The Total remuneration figure for the CEO in 2022 included vesting of the top-up award made in May 2020 which did not vest until May 2023. The final actual value received has been updated, bringing the total value to £3.662 million (previously reported as £3.666 million) (5) 2021 PSP vesting in 2024: For the CEO, the figure has been valued based on the vesting prices on 9 February 2024 of £16.60. The share price on 10 February 2021, the date of grant, was £12.77. Of the vested amounts for the Executive Directors, 23.1% of the value was attributable to share price appreciation over the performance period. The Committee did not exercise any discretion in relation to the vesting of the awards or share price changes (6) The PSP vesting value for the former CFO is unreduced and is an illustrative amount as the award will not vest until January 2025 in accordance with the terms of the Executive and Senior Management Recoupment Policy (Recoupment Policy). His award will then remain subject to the two-year holding period which started from the original vesting date of the award in February 2024. The actual value received will be updated in the 2024 Annual Report. Further details of the former CFO’s leaving arrangements are set out in the Leaving Directors section on page 154 (7) The CEO and CFO each contribute the maximum of £250 and £125 a month into the Share Save plan and to buy shares under the Share Reward plan respectively. Further details of these HM Revenue & Customs (HMRC) approved all-employee plans are set out on page 147 (8) Malus and clawback: The Committee may in specific circumstances, and in line with stated principles, apply malus/clawback, as it determines appropriate. Following due consideration by the Committee, there has been no recovery of sums paid (clawback) or reduction of outstanding awards or vesting levels (malus) applied during 2023 in respect of any of the CEO, CFO or the former CFO 142 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued 2023 Total remuneration (audited) continued Fixed pay (audited) Salary The Committee is very aware of the sensitivity amongst stakeholders to levels of pay. Before setting or reviewing salary, it considered the average increases awarded to employees below Executive Directors and the multiplier effect of increases in base salaries on total remuneration opportunity. The Committee considered the wider economic context, individual performance and market positioning of the increases awarded. The table below sets out the base salaries and increases agreed for 2023 and 2024 of the Executive Directors compared to increases of the UK workforce. % change Salary £000 2023 effective date 2024 2023 2024 2023 2022 UK employees Emma Walmsley Julie Brown 1 April 1 January 1 May 4 4 4 5 4 4 1,363 990 1,310 952 1,260 — Julie Brown's salary on the announcement of her appointment in September 2022 was set in line with her predecessor, given her extensive experience as a CFO. Her salary upon joining was increased to reflect the increases awarded to UK employees and the CEO in early 2023. Benefits This table provides an analysis of total benefits (grossed up for tax) received by the Executive Directors in 2023 and 2022. The UK remuneration reporting regulations require the company to add into each Executive Director’s total benefits all items which are deemed by tax authorities to be a taxable benefit for them. These include employee benefits as well as business-related services provided to employees to assist or enable them to carry out their role, which a tax authority has deemed to be a taxable “benefit” to the individual. Because these are business expenses, the company meets the tax which arises on them and therefore the items are shown grossed up for tax. Emma Walmsley Benefits available to employees Business-related services Total benefits Julie Brown Benefits available to employees Business-related services Total benefits Benefits £000 2022 66 65 131 — — — 2023 118 94 212 25 25 50 Pensions From 1 January 2023, pension arrangements for Executive Directors were aligned to the wider workforce. They received GSK pension contributions or cash supplements of 7% of base salary and matching contributions of up to 3% on the first £26,666 of salary to 31 March 2023 and on the first £66,666 of salary for the rest of 2023. The table shows the breakdown of the pension values included in 2023 Total remuneration on page 142. They are calculated as set out in the UK Large and Medium-sized Companies and Groups (Accounts and Reports) Regulations 2008 (as amended) (Remuneration regulations). Pension remuneration values UK defined contribution Employer cash contributions Pension Emma Walmsley 2022 3 250 253 2023 6 88 94 Julie Brown (from May 2023) 2022 — — — 2023 — 44 44 143 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Pay for performance (audited) Annual Bonus Total sales growth 30% + Adjusted operating profit growth 30% + Strategic and operational measures 30% + ESG: DEI 10% = Annual Bonus l Financial Measures: 60% l Non-Financial Measures: 40% 2023 Annual Bonus performance The following table shows the Annual Bonuses earned compared to the bonus opportunity for 2023: 2023 Bonus opportunity Bonus Emma Walmsley Julie Brown Target (% of salary) Maximum (% of salary) 2023 salary £000 100 300 1,310 952 % of Maximum Bonus 96 66 % of Salary 288 197 Cash 1,310 940 2023 Bonus outcome Paid as (£000) Shares (DABP Award) 2,463 940 Details of the mandatory deferral by Executive Directors into the DABP for the 2023 bonus are set out on page 156. See page 154 for details of Iain Mackay's 2023 bonus arrangements following his retirement from the company. Julie Brown's bonus has been pro-rated to reflect the period for which she was employed in 2023. The table on page 142 provides the details of her bonus from 1 May when she became an Executive Director. 2023 Financial measures Total sales growth Adjusted operating profit growth These targets were set following consideration of analyst consensus as well as internal budgets. Threshold and maximum performance was at 1% below and 5% above target growth respectively. The total sales growth and adjusted operating profit growth targets and outcomes for the purposes of the Annual Bonus calculation are based on CER and excluding the commercial benefit from COVID-19 solutions. Overview of performance against financial performance measures – GSK delivered strong performance in 2023 with sales, adjusted operating profit and adjusted EPS all growing at double- digit levels for the year (excluding COVID-19 solutions). This was significantly higher than the guidance provided at the start of the year, and strongly supports delivery of GSK’s growth outlooks for the period 2021-26 – Delivered full-year reported Group sales of £30.3 billion (+3% AER, +5% CER, +14% excluding COVID-19 solutions) – Vaccines growth was 23% AER, 24% CER, with Arexvy sales of £1.2 billion since launch in Q3 2023 and Specialty growth was 21% AER, 23% CER (all excluding COVID-19 solutions) – Adjusted Group Operating profit CER growth of 16% excluding COVID-19 solutions, driven by higher sales supported by prioritised increased investment in R&D and new product launches – Adjusted EPS of 155.1p (+11% AER, +16% CER, +22% excluding COVID-19 solutions) was ahead of updated guidance 144 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Pay for performance (audited) continued 2023 Strategic and operational measures The Committee received and considered a performance assessment report for each Executive Director showing the extent of their achievement against the individual personal strategic and operational measures agreed by the Committee for them to support the delivery of our strategic commitments during 2023. As with the financial elements of the Annual Bonus, the Committee was satisfied that the scale of Executive Directors’ achievements this year was excellent. These achievements focus on the pipeline, commercial execution and continued evolution of our culture. Achievement during 2023 Performance assessment Emma Walmsley Innovation – Delivered pipeline progression above target with four major product approvals in RSV prevention, HIV Exceeded prevention and Oncology – Delivered innovation sales through successful launches including Arexvy. New products launched since 2021 contributed £2.3 billion to sales in 2023 – Upgraded long-term outlooks for sales and profits with 2021-2026 outlooks for sales now more than 7% and adjusted operating profit growth now more than 11% CAGR (excluding COVID-19 solutions). 2031 sales outlook increased to more than £38 billion (CER using 2023 average rates) Performance – Delivered the financial plan exceeding guidance set for 2023 – with Sales +14% excluding COVID-19 Exceeded solutions and adjusted operating profit up 12% with further positive impact of +4% excluding COVID-19 solutions, and adjusted EPS grew 16% with further positive impact of +6% excluding COVID-19 solutions (All at CER). Group sales were £30.3 billion Trust – Sector leader in S&P Global Corporate Sustainability Assessment – Access and Global Health – 89 million people in lower income countries reached through access Exceeded partnerships. Malaria vaccine roll out in up to 12 countries. 11 global health pipeline assets progressing – Environmental Sustainability – progress on all KPIs, including progression of low carbon Ventolin inhaler programme to phase III development – Diversity, Equity & Inclusion – 2025 aspirations for gender diversity and UK and US 2025 ethnicity aspirations at VP and above achieved Culture – Annual survey of employee engagement reported increase to 81% Exceeded The Committee determined that the CEO clearly exceeded her individual objectives and that 78% out of the 90% maximum should be attributed to her overall bonus Julie Brown Demonstrate financial leadership Cost discipline and cash flow management Demonstrate strong culture and leadership – Deep review of pipeline forecasting to support upgrading of long-term outlooks to 2031 and beyond – Design of new investor engagement programme, including development of an Investor Relations Exceeded Roadmap and communication of long-term outlooks – Deep review of capital allocation and pipeline value ‘unlocks’ to support investment in organic R&D Exceeded and Business Development; and to maximise returns to shareholders – Initiated work to drive P&L efficiency with a focus on SG&A and operating margin improvement – Successfully integrated into GSK and established strong partnership working with CEO and members of Met GLT, with notable output to support R&D and the Commercial organisations The Committee determined that the CFO clearly met her individual objectives and that 54% out of the 90% maximum should be attributed to her overall bonus 2023 ESG: DEI aspirations Emma Walmsley Enterprise targets not met Julie Brown Directorate targets not met Payout level Nil (0%) Enterprise targets met, but not all directorate targets Personal directorate targets met Target (10%) Enterprise and all directorate targets met Maximum (20%) Outcome achieved Maximum payout – 20% Maximum payout – 20% Overview of performance against DEI aspirations Our ESG: DEI measure reinforces delivery of our commitment to create a diverse, equitable and inclusive workplace. Our broader DEI commitments are set out on page 52. As part of our effort to meet our 2025 Aspirational Targets for diversity of senior leadership, the Committee agreed interim, annual aspirational targets for 2023 including global gender representation and US and UK race and ethnicity representation aspirations at an enterprise level for the CEO and at a directorate level for the CFO. An internal governance team audited performance against these aspirations for the Committee. Delivery: These interim aspirations were met in 2023. At the year end the GSK Enterprise performance was 45% gender representation and 35.7% US ethnicity and 18.4% UK ethnicity in our VP and above employee population. Julie Brown's directorate also met its 2023 aspirations. 145 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Pay for performance (audited) continued Vesting of PSP LTI awards Pipeline Progress 20% + Innovation Sales 20% + Adjusted Free Cash Flow 30% + Relative Total Shareholder Return 30% = Total Vested LTI Overview of Performance In line with the Committee’s agreed principles, actual performance against each measure is carefully reviewed and adjustments are made, as appropriate. This ensures that the vesting outcome reflects genuine underlying business performance and has been delivered in line with our culture and values. The Committee did not deem it necessary to exercise any discretion in relation to the vesting of the awards or due to share price changes. Overall, 69.95% of the 2021 PSP awards vested against the targets set out below. During the 2021-23 performance period, significant progress was achieved in accelerating the delivery of our pipeline. Near full vesting was achieved under Innovation sales, reflecting increases in the performance of Trelegy, Nucala, Dovato and Benlysta during the period. Strong performance was evidenced with full vesting under the Adjusted free cash flow and Pipeline progress elements; however, disappointingly there was nil-vesting under Relative TSR. The percentage of award values vesting below have been rounded down to whole numbers for presentational purposes. 2021 PSP Outcomes Performance measures and relative weighting Pipeline progress (20%) Performance targets Targets strengthening our pipeline through progression of high quality assets into pivotal trials and the achievement of regulatory approvals in major markets. The points are allocated on achievement of these two equally weighted elements of 10% Measure Threshold 25% Pivotal Trial starts Major regulatory approval milestones 12 13 50% 14 15 75% 16 17 Maximum 100% 17 19 Innovation sales (20%) Recognises the importance of launching new products successfully and that driving their performance is key to our commercial success. This measure aggregates three-year sales for new innovative products launched in the three- year performance period and the preceding two years, i.e. 2019-23 Innovation sales (billion) % vesting Maximum Threshold £18.67 £16.97 £16.12 £15.27 <£15.27 100 75 50 25 0 Outcome and vesting level Outcome % of maximum % of award 18 points 20 points £18.65 billion 100 100 99.8 20 19 Adjusted free cash flow (AFCF) (30%) In line with the company’s agreed principles, the AFCF figures included adjustments for a number of material distorting items, including legal settlements, exchange rate movements and special pension contributions £9.81 billion 100 30 Revised target (billion)(1) % vesting Maximum Threshold £6.54 £6.26 £5.69 £5.52 <£5.52 100 75 50 25 0 (1) The revised target has been further adjusted since the 2022 Annual Report as noted below Relative TSR (30%) TSR ranking within comparator group (10 companies) Maximum 1st, 2nd, 3rd Threshold(2) 4th 5th Median 6th to 10th % vesting 100 70 40 25 0 Ranked 9th 0 0 (2) The median vesting threshold falls between two companies. The Relative TSR comparator group is set out on page 152 Total vesting in respect of 2021 PSP awards 69 The AFCF measure target, threshold and associated vesting scales for the 2021 PSP awards have been further adjusted since being restated in the 2022 Annual Report. The net overall impact is an increase in the revised target from £5.64 billion to £5.69 billion for the 2021 PSP awards. The adjustment takes into account revised timings of restructuring payments linked to the Future Ready programme. 146 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Pay for performance (audited) continued 2021 PSP vesting Emma Walmsley Granted 550,757 Vested(1) 441,309 Value of vested shares(1) (£000) £7,328 (1) The number of shares which vested and the value they represented at vesting includes dividend reinvestments during the performance period. These are based on the vesting price of £16.60 on 9 February 2024 (2) The PSP award for Dr Hal Barron vested and was adjusted for time worked during the performance period, including dividend reinvestments. 153,505 shares vested at a value of $4.492 million. Shares were sold for tax and will be held for two years under the terms of the Recoupment Policy (3) The Committee is aware of the guidance from investor bodies regarding the potential executive benefit arising from share award grants around the time of the stock market fall at the onset of COVID-19 in March 2020. Our Remuneration policy contains sufficient flexibility to reduce the vesting of awards if required. No reduction was required in respect of the awards granted in February 2021. In making this determination, the Committee considered the share price at the time of the February 2021 award of £12.77, over the final quarter of 2023 of £14.46 and at the time of the previous award in February 2020 of £16.81. Whilst there have been upward and downward movements in GSK's share price over the period, taking these points into consideration the Committee was satisfied that there was no risk of windfall gains 2023 LTI grants The 2023 DABP awards, in respect of the deferral of 2022 bonus, and the 2023 PSP awards are set out below. Emma Walmsley Julie Brown Iain Mackay % of total 2022 bonus deferred 60 — 56 2023 DABP awards Face value of award(1) £000 1,883 — 1,167 Number of shares 125,482 — 77,751 Award level as % of base salary 575 400 — 2023 PSP awards Face value of award(2)(3) £000 7,534 3,808 — Number of shares 501,927 264,026 — (1) The face value of the DABP awards has been calculated based on a share price of £15.01, being the closing price on 8 February 2023 (the day before grant). These are nil-cost options for the Executive Directors. No performance conditions are attached to the DABP awards, as they reflect the mandatory three-year deferrals in respect of the Annual Bonus for 2022 (2) The face values of the PSP awards have been calculated based on a share price of £15.01 for Emma Walmsley and £14.422 for Julie Brown, being the closing price on 8 February 2023 and 26 April 2023 respectively (the days before the respective grants). The unreduced PSP award for Julie Brown was granted in conjunction with her joining arrangements as detailed on page 149 of the 2022 Annual Report. These are conditional shares, based on the performance measures above. Iain Mackay did not receive a PSP award due to his retirement from the company (3) Performance period for the 2023 PSP awards is from 1 January 2023 to 31 December 2025. Awards vest at 25% of maximum for threshold performance. Please see the 2022 Directors Remuneration Report for details of the measures and targets for the 2023 awards Historical vesting for LTI plans The following table summarises LTI vesting by performance measure for GSK over the last ten years. 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 Relative TSR Adjusted free cash flow Innovation sales (previously R&D new product) Pipeline progress Business diversification Total vested % 0 0 7 7 14 0 0 21 17 38 0 0 33 15 21 33 0 26 33 0 33 33 0 33 33 0 33 25 0 30 8 14 0 30 19 20 33 69 59 67 67 58 52 69 All-employee share plans The Executive Directors may participate in HMRC approved all-employee share plans, namely the company’s Share Save and Share Reward plans, along with the wider UK workforce. Participants of the Share Save plan may save up to £250 a month for three years and from which they have the option to buy GSK shares at a discount of up to 20% to the share price at the start of the savings contract. Participants of the Share Reward plan contribute up to £125 a month to purchase GSK shares which the company then matches on a one-for-one basis. Malus and clawback policy Our existing policy on malus and clawback is provided in the 2022 Remuneration policy report on page 147 of the 2021 Annual Report, available on gsk.com. The Committee reviews and discloses whether it, or the Recoupment Committee, has exercised malus or clawback. Disclosure is only made when the matter has been the subject of public reports of misconduct, where it has been fully resolved, where it is legally permissible to disclose and where it can be made without unduly prejudicing the company and therefore shareholders. In line with these disclosure guidelines, there were no matters to report during 2023. An administrative amendment to the malus and clawback section of the 2022 Remuneration policy, as described on page 163 of the 2022 Annual Report, was approved by shareholders at the 2023 AGM. The Committee then adopted an additional clawback policy in accordance with the US Securities and Exchange Commission's new clawback rules effective 30 November 2023. For details of our existing policies on recruitment remuneration, loss of office and termination payments, please refer to the 2022 Remuneration policy report on pages 144 to 152 of the 2021 Annual Report, available on gsk.com. 147 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Pay for performance (audited) continued Pay for performance in 2024 2024 Annual Bonus – Performance measures There are no changes to the operation of the Annual Bonus plan. For full details of the policy please refer to pages 145 and 146 of the 2021 Annual Report. Emma Walmsley Julie Brown Bonus opportunity % of salary Maximum(1) 300 Target 100 (1) 50% of the equivalent of the first 200% of salary is deferred, and any portion in excess of 200% is deferred in full Weighting of performance measures Emma Walmsley Julie Brown Total sales growth Adjusted operating profit growth Strategic and operational measures ESG: diversity, equity and inclusion Weighting of performance measures % 30 30 30 10 Inevitably, targets linked directly to our financial and strategic plan are commercially sensitive. The Committee does not consider it appropriate to disclose Annual Bonus targets during the year, as it may result in competitive harm. However, details of the performance targets will, as usual, be disclosed on a retrospective basis in the 2024 Annual Report. 2024 LTI Awards The table below provides details of: – the mandatory deferral into the DABP of the 2023 Annual Bonus payments and the associated awards granted. The shares awarded have no performance conditions, but must be held for three years, regardless of continued employment – 2024 awards granted under the PSP 2023 bonus deferred to shares (% of salary) Number of shares Face value of award (£000) % base salary Number of shares Face value of award (£000) DABP awards PSP awards Emma Walmsley Julie Brown 188 99 147,271 56,190 2,463 940 575 400 468,449 236,763 7,835 3,960 148 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Pay for performance (audited) continued 2024 LTI performance measures The measures and weightings for the 2024 awards remain unchanged from those used for the 2023 awards: Innovation Performance Trust Measure Pipeline progress Relative TSR Total sales growth Adjusted operating profit growth ESG: environment Weighting 20% 30% 20% 20% 10% Innovation The Pipeline progress measure seeks to reward acceleration and strengthening of the pipeline. This is based on two equally weighted elements of our key assets or indications measured over a three-year performance period. Points are allocated for successful assets in each sub-measure based upon their forecast commercial value (peak year sales) at the end of the performance period. The sub-measures for the 2024 award will vest as follows: Pivotal trial starts Focuses mainly on phase III registrational trial starts, but may also include phase II starts. Performance level Below Threshold Threshold Maximum Major regulatory approvals Performance level Below Threshold Threshold Maximum Points <15 15 18 22 26 Points <17 17 20 22 24 Payout Nil 25% 50% 75% 100% Payout Nil 25% 50% 75% 100% The Pipeline progress measure is commercially sensitive at the time of grant. At the end of the performance period we will provide disclosure of what has been achieved. Performance Relative TSR will continue to be measured against GSK’s Global pharmaceutical comparator group (see page 152). The total sales growth and adjusted operating profit growth measures recognise the importance of our commercial ambitions. The targets for total sales growth and adjusted operating profit growth are commercially sensitive at the time of grant. Trust The ESG: environment measure is based on our Climate and Nature goals (see page 49). The targets for the 2024 award focus on Nature goals relating to Water, Waste & Materials reduction and Biodiversity impact. Climate goals incorporate Scope 1 & 2 emission reduction targets, carbon offsetting and our industrialisation and availability of green Ventolin. To achieve: – 25% vesting, targets for two measures achieved at the end of 2026, with one in Climate and one in Nature – 50% vesting, targets for four measures achieved at the end of 2026 – 75% vesting, all six measures must have met their 2026 targets – 100% vesting, two of the six measures, at least one in Climate and one in Nature, must have exceeded their 2026 targets 149 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Directors’ pay in a wider setting Internal context Comparison of remuneration structure for employees and Executive Directors during 2023 Element Salary Wider workforce and Executive Director pay The market competitiveness of base salaries across the company is assessed at a local market level. The competitiveness of roles is kept under regular review Increases may also be made to reflect a change in scope of an individual’s role, responsibilities or experience For our Executive Directors following a performance review, increases in base salaries are considered in line with market practice, the average increase for the wider employee population and other comparator tools In agreeing increases for Executive Directors, the Committee is mindful of the multiplier effect on the individual’s total remuneration Benefits and pensions The company seeks to provide an appropriate benefits and pensions package that is aligned to competitive market practices in those countries in which the company operates and where our employees and Executive Directors are based Annual Bonus With the exception of our sales force, who participate in separate arrangements, our wider workforce participates in a plan based on performance against four business and financial measures. These are structured to reflect the priorities of each specific business area This plan is designed to reward our employees’ collective contribution to business achievement Separate mechanisms are in place to recognise outstanding individual performance or to address under- performance Our Executive Directors participate in the plan as follows. Any bonus up to 200% of salary is paid 50% in cash and 50% in shares deferred for three years. Bonus earned in excess of this (up to a maximum of 300% of salary) would be delivered fully in shares deferred for three years. Clawback and/or malus provisions apply LTI plans Senior Vice President (SVP) and Vice President (VP) employees participate in the same Performance Share Plan as our Executive Directors. Clawback and/or malus provisions apply Our SVP and VP employees, together with directors and managers below the GLT, receive annual Share Value Plan awards of restricted shares Share ownership All UK-based employees can participate in HMRC approved Share Save and Share Reward employee share plans. Dilution limits All awards are made under plans which incorporate dilution limits consistent with the guidelines published by the Investment Association. These limits are 10% in any rolling ten-year period for all plans and 5% in any rolling ten-year period for executive share plans (granted to senior executives). Estimated dilution from existing awards made over the last ten years up to 31 December 2023 is as follows: All GSK employee share plans Executive share plans 150 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Directors' pay in a wider setting continued CEO and wider employee pay ratio Financial year Lower quartile P25 2023 2022 2021 2020 2019 207:1 144:1 154:1 130:1 160:1 Median P50 152:1 106:1 108:1 96:1 119:1 Upper quartile P75 94:1 67:1 67:1 62:1 73:1 GSK continues to use the Option A methodology because it is the most robust and statistically accurate way to calculate the three ratios from the options available under the Remuneration regulations. The pay ratio is higher than in 2022 influenced by the company's strong performance which has delivered an increased bonus for all. The CEO vest was also much higher than in previous years due to the improvement in the GSK share price. The 2021 award was granted at £12.77 and vested at £16.60. The pay ratios above are calculated using actual earnings for the CEO and UK employees. The CEO’s total single figure remuneration of £12.718 million for 2023 and £8.449 million for 2022 are detailed on page 142. Total remuneration for all UK full-time equivalent employees on 31 December 2023 has been calculated in line with the single figure methodology. This reflects their actual earnings received in 2023 (excluding business expenses), which were used to produce the percentile calculation under Option A of the Remuneration regulations. Business expenses have been excluded as they are reimbursed to employees and are not sufficiently substantial in value to significantly impact the ratios. The table below shows the salary, total pay and benefits for each of the percentiles. £ 2023 P25 2022 2021 2020 2023 2022 2021 2020 P50 2022 2021 2020 2023 P75 Salary 39,903 37,776 37,251 36,924 55,057 52,107 51,492 50,000 78,496 74,905 72,997 70,203 Total pay and benefits 61,490 58,883 53,151 54,133 83,783 79,428 76,234 73,340 135,819 126,594 122,852 113,830 The Committee believes that the median pay ratio is consistent with the company’s pay, reward and progression policies. The base salaries of all employees, including the Executive Directors, are set with reference to a range of factors including market practice, experience and performance in role. Relative importance of spend on pay The table shows total employee pay and dividends paid to shareholders. Total employee pay Dividends paid in the year Change % 10.1 (35.2) 2023 £m 8,473 2,247 2022 £m 7,693 3,467 The figures in this table, reflecting payments made during each year and the impact of movements in exchange rates, are as set out on pages 199 and 206. However, cash dividends declared in respect of 2023 were £2,352 million (2022: £2,470 million) a decrease of 4.8%. Please see Note 16 to the financial statements for further details. Total employee pay is based on 70,244 employees, the average number of people employed during 2023 (2022: 69,130). See Note 9 to the financial statements for further details. The last share repurchase made by the company was in 2014. 151 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Directors' pay in a wider setting continued External context 2023 target CEO total remuneration positioning When reviewing the CEO’s remuneration, the Committee’s primary comparator group is the European cross-industry comparator group. It also references pay for the Global pharmaceutical comparator group. Remuneration includes salary and the expected value of incentives based on the Committee’s agreed benchmarking methodology Historic CEO remuneration 2023 2022 2021 2020 2019 2018 2017 £000 12,718 8,449 8,203 7,031 8,094 5,887 4,883(1) 96% 83% 93% 49% 79% 93% 77% 69% 52% 58% 67% 67% 59% 69% Emma Walmsley Total remuneration % of maximum Annual Bonus award Vesting of LTI awards Sir Andrew Witty Total remuneration % of maximum Annual Bonus award Vesting of LTI awards £000 2016 2015 2014 6,830 6,661 3,902 97% 100% 42% 33% 38% 14% 2017 715 (2) 0%(2) 0%(3) (1) Emma Walmsley’s total remuneration includes her pay for the period 1 January to 31 March 2017, before she became CEO (2) Sir Andrew Witty received a pro-rata payment for 2017 in lieu of a variable bonus opportunity, in accordance with the 2014 Remuneration policy (3) PSP and DABP awards for Sir Andrew Witty granted in 2015 did not vest until April 2018, in accordance with the terms of the Recoupment Policy Comparator groups The European cross-industry comparator group is the Committee's primary comparator group for the CEO and CFO. The Global pharmaceutical comparator group is the secondary group for the CEO, and is also used to measure relative TSR performance. Deutsche Telekom Kering Heineken BASF Vinci Adidas Bayer Safran Reckitt Benckiser European cross-industry comparator group Roche Holding AG Novartis LVMH Anheuser-Busch InBev Unilever SAP L’Oreal Novo Nordisk A/S Airbus Linde Sanofi AstraZeneca Diageo Siemens Christian Dior Inditex BAT Volkswagen Global pharmaceutical comparator group France Sanofi Switzerland Novartis Roche Holdings UK AstraZeneca US AbbVie(1) Amgen(1) Bristol-Myers Squibb Eli Lilly Johnson & Johnson Merck & Co Pfizer (1) AbbVie and Amgen are included for remuneration benchmarking, but are not included in the relative TSR performance comparator group TSR Performance graph The following graph sets out the performance of the company relative to the FTSE 100 Index and to the Global pharmaceutical performance comparator group for the ten-year period to 31 December 2023. These indices were selected for comparison purposes as they reflect both the primary index of which GSK is a constituent and the industry in which GSK operates. 152 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Remuneration governance Committee role and membership These details are available on page 116 and are incorporated by reference into this Report. The Chair, CEO, Chief People Officer, Head of Reward, Group Financial Controller and the Company Secretary assisted the Committee during the year. Adviser to the Committee Independent adviser Willis Towers Watson plc (WTW) WTW is a member of the Remuneration Consultants Group and operates under its code of conduct for executive remuneration consulting in the UK which can be accessed at: www.remunerationconsultantsgroup.com The principal proxy advisory firms are also consulted regularly. They were also invited to our Annual Governance Meeting and are sent engagement letters from the Committee and company Chairs. AGM voting Details of voting levels in respect of our Remuneration arrangements are set out below. Total votes cast (billion) Total votes for (%) Total votes against (%) Votes withheld (million) 2023 AGM 2.8 2.9 3.6 3.6 88.8 99.0 91.1 61.8 11.2 1.0 8.9 38.2 70.1 10.7 12.3 13.3 Appointed 1 December 2022 following a tender process Remuneration Report Amendments to 2022 Remuneration Policy 2022 AGM Remuneration Report Remuneration Policy Advice provided The Committee is comfortable that the WTW engagement partner and team that provides remuneration advice to the Committee do not have connections with the company or its Directors that may impair their independence Fees Conflicts of interest Charged on a time and materials basis: 2023: £63,419 (2022: £4,000 for one month in 2022) WTW provides market data and other HR consulting services to the company. The Committee regularly reviews the arrangements for potential conflicts and where appropriate ensures safeguards are in place Statement of consideration of shareholder views The Committee engages in regular dialogue with shareholders and holds regular meetings with GSK’s largest investors to discuss and take feedback on its Remuneration policy practices and governance matters. 2023 ongoing engagement Details of the extensive consultation by the Committee and company Chairs regarding remuneration matters prior to the 2023 AGM vote and continuing engagement with shareholders afterwards, are set out below. Shareholder engagement events Dates Meetings held prior to AGM January to April 2023 Investor participation Share capital represented 8 investors 10% Meetings held after the AGM to the publication of this Annual Report May 2023 to February 2024 22 investors 25% 2023 Annual Governance Meeting: – invitations – attendance November 2023 December 2023 78 investors 15 investors 50% 25% 153 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Remuneration governance continued Committee focus during 2023 Items discussed Remuneration policy – Prepared, agreed and proposed administrative amendments to the 2022 Remuneration Policy – Continued engagement with shareholders and reviewed and considered shareholder and proxy advisor feedback Fixed Pay – Considered Executive Director and GLT performance, benchmarking competitiveness against GSK comparator groups – Reviewed GLT and Company Secretary salary recommendations for 2023 – Executive Director salary review recommendations for 2023 and 2024 – Reviewed company Chair’s fees for 2023 and 2024 Pay for Performance Annual Bonus – Executive Director and GLT 2022 bonus recommendations and set 2023 Executive Directors’ bonus objectives LTI plans – Considered the LTI performance outcomes and award vesting for the CEO, Executive Directors, Governance and other areas of focus GLT and below – Confirmed LTI grants for Executive Directors, GLT and below – Remuneration considerations and Committee programme for 2023 and 2024 – Committee evaluation and Annual Review of its Terms of Reference – Approved 2022 Remuneration report – Confirmed 2023 Group Budget for remuneration purposes – Considered AGM and Remuneration report feedback, the external remuneration environment and performance target disclosure for incentive plans – Agreed Committee's key messages for Annual Governance Meeting – Committee Chair consulted with employee representatives on wider workforce pay practices and pay generally Leaving Directors To support the CFO succession and transition process, as announced in September 2022 and set out in the 2022 Annual Report, after stepping down from the Board Iain Mackay continued to receive remuneration until he left GSK on 31 December 2023. This was in line with the current Remuneration policy. His base salary was not increased during 2023. Whilst serving as an Executive Director (until 1 May 2023) he received total benefits of £82,000 (comprising £67,000 for benefits that are available to employees and £15,000 for business-related services). The value of his pension until May 2023 totalled £22,000 (comprising £2,000 UK defined contribution and £20,000 employer cash contributions). See page 143 for further explanation. As an employee to the end of 2023, he remained eligible to receive a bonus under the Executive bonus plan for 2023 based on delivery of the measures described on page 144. This was reviewed by the Committee and determined to be £2,196,810 in total for the year, comprising £915,335 in cash and £1,281,475 delivered as GSK shares deferred for three years under the DABP plan. The bonus value in respect of the period he served as an Executive Director was £728,000. He was not eligible for and therefore did not receive any further PSP awards in 2023 given he was due to leave GSK. Vesting of his existing LTI awards will be in accordance with the Recoupment Policy. With regard to the 2021 PSP award of 278,363 ordinary shares, this will not vest until January 2025. 69.95% of the award (223,045 shares inclusive of dividends) will vest in accordance with the performance described on page 142. The illustrative unreduced value for this award is disclosed in the Single figure table on page and the value at the time of vesting will be updated in the 2024 Annual Report. Since his executive service contract ended on 31 December 2023, he will be required to satisfy the post-employment share ownership requirement as set out on page 156. Payments (audited): to past Directors for loss of office No payments were made to past Directors in 2023 No loss of office payments were made during 2023 154 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Non-Executive Directors’ fees The company aims to provide the Chair and other Non-Executive Directors with fees that are competitive with those paid by other companies of equivalent size and complexity, subject to the limits contained in its Articles of Association. 2023 Non-Executive Directors’ fees The Non-Executive Directors’ fees that applied during 2023 are set out in the table below together with the fees for 2024: Chair fee Standard NED annual fee Supplemental fees Chair of the Audit & Risk Committee Senior Independent Director Scientific & Medical Experts Chairs of the Remuneration, Corporate Responsibility and Science committees and, when appointed, Workforce Engagement Director 2023 £735,000 £113,800 £80,000 £50,000 £30,000 £40,000 Per annum 2024 £764,400 £118,352 £80,000 £50,000 £30,000 £40,000 Science Committee members undertaking significant additional responsibilities on behalf of GSK Up to £200,000 Up to £200,000 Following a review and approval by the Committee at the end of 2023 it was determined that the Chair's fee should be increased from £735,000 with effect from 1 January 2024 by 4% to £764,400. The Chair and the CEO also recommended that the Board approve an increase to the Non-Executive Directors' standard annual fee, with effect from 1 January 2024, by 4% to £118,352 in line with the increase awarded to the wider UK workforce. 2023 Total fees (audited) The audited table below sets out the value of fees and benefits received by the Non-Executive Directors in the form of cash and shares or ADS. Non-Executive Directors' fees paid in a currency other than Sterling are converted using an average exchange rate that is reviewed from time to time. The average exchange rates were updated in 2023. In 2023, Non-Executive Directors fees were converted to US Dollars using an exchange rate of $1.175. Benefits comprise the grossed up cash value of travel and subsistence costs incurred in the normal course of business, in relation to attendance at Board and Committee meetings and in fulfilling their role. Non-Executive Directors’ emoluments (000) (audited) Sir Jonathan Symonds Elizabeth Anderson Charles Bancroft Dr Hal Barron Dr Anne Beal Wendy Becker Dr Hal Dietz Dr Jesse Goodman Urs Rohner Dr Vishal Sikka Fixed fees Fixed fees Cash Shares/ADS Benefits Total pay Cash Shares/ADS Benefits Total pay 2023 2022 £551 $100 — $344 $156 £21 $191 $144 £133 — £184 $33 $295 $33 $33 £7 $33 $33 £28 $134 £30 $30 $28 $78 $34 £4 $40 $44 £40 $13 £765 $163 $323 $455 $223 £32 $264 $221 £201 $147 £525 $35 — $150 $138 — $174 $182 £112 — £175 $8 $287 $16 $46 — $58 $61 £31 $58 £10 — $10 $11 $15 — $2 $31 £23 — £710 $43 $297 $177 $199 — $234 $274 £166 $58 Non-Executive Director section of 2022 Remuneration policy At the 2023 AGM, shareholders approved an administrative amendment to the Non-Executive Director section of the Remuneration policy to allow the notional shares or ADS previously allocated under the Non-Executive Director plan to be delivered to the Chair and Non-Executive Directors at such time as the Committee and Board considered appropriate after any applicable tax withholding. The Chair and Mr Rohner's notional shares were released to them after the AGM in 2023. It is expected that the other Non-Executive Directors holdings will be released to them following the company's AGM in May 2024. The company does not expect to make any significant changes to the fee structure for the Chair and Non-Executive Directors during the remainder of the 2022 Remuneration policy period. 155 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Directors’ interests in shares (audited) Executive Directors’ interests in shares The interests of the Executive Directors of the company in office during 2023 and their persons closely associated (PCA) are shown in the table below: As at 31 December 2023 or date of retirement Unvested share plan interests Total directors’ interests(1) Beneficial interests Not subject to performance Emma Walmsley Julie Brown Iain Mackay(6) 23 February 2024 31 December 2023 or date of retirement 1,974,235 98,685 — 1,542,803 23,105 475,857 None of the Directors hold vested but unexercised options. Shares(2) 733,961 23,105 21,892 Shares(3) 549,998 — 287,488 Options(4,7) 258,843 — 166,477 Subject to performance Shares(5) 1,636,924 269,262 555,267 (1) Total directors’ interests includes beneficial interests and unvested share plan interests not subject to performance. For Emma Walmsley, the balance as at 23 February 2024 includes shares awarded in 2021, under the PSP and the DABP which vested in February 2024 less those sold to satisfy tax liabilities on the vested amounts where relevant. Shares awarded in 2021 under the PSP and the DABP to Iain Mackay will not vest until January 2025 in accordance with the terms of the Recoupment Policy. Executive Directors’ shareholdings against their SOR are outlined below (2) Beneficial interests includes shares held by the Executive Directors and their PCAs. For Emma Walmsley and Julie Brown, this includes 2,463 shares and 86 shares respectively purchased through the Share Reward plan (3) Unvested shares not subject to performance represent PSP shares which have vested but are subject to an additional two-year holding period (4) Unvested options not subject to performance represent bonus deferrals under the DABP which are awarded as nil-cost options (as described in note 7 below). This figure excludes 790 options and 828 options held by Emma Walmsley and Julie Brown respectively under the Share Save plan (5) Unvested shares subject to performance represent unvested PSP awards (6) Iain Mackay retired from the Board on 1 May 2023 (7) DABP: The table below shows bonus deferrals and subsequent reinvestment of dividends under the DABP. The amounts represent the gross share balances prior to the sale of any shares to satisfy tax liabilities on vesting DABP (Bonus deferrals) Emma Walmsley Julie Brown Iain Mackay 23 February 2024 31 December 2023 or date of retirement 1 January 2023 356,006 56,190 — 258,843 — 166,477 184,990 — 127,002 The following table sets out details of nil-cost options exercised during 2023 by Executive Directors: Emma Walmsley Iain Mackay Date of grant 14.02.2020 14.02.2020 Number of shares under option 60,707 40,985 Date of exercise 14.02.23 14.02.23 Grant price £0.00 £0.00 Market price at exercise Gain on exercise (000) £14.87 £14.89 £903 £610 The nil-cost options awarded in 2020 under the DABP represent the bonus deferred by the Executive Director and recorded as remuneration (under Annual Bonus) in the 2019 Total remuneration table. The number of shares under option includes the initial award together with reinvested dividends accrued to the date of exercise. Executive Directors' Share ownership requirements (SOR) (audited) To align the interests of Executive Directors with those of shareholders, they are required to build and maintain significant holdings of shares in GSK over time. Executive Directors are required to continue to satisfy this SOR by holding 100% of their SOR for the first 12 months after leaving GSK and not less than 50% of their SOR for months 13-24 thereafter. Shares subject to performance conditions are excluded from the SOR calculation until the end of the performance period. These vested shares are then included to the extent that the performance conditions are met. The value of the holdings has been calculated on a post-tax basis. Iain Mackay exceeded his SOR at the date of his retirement from the Board and continues to maintain his SOR. Emma Walmsley Julie Brown Value of holdings as % of salary SOR % of salary 23 February 2024 31 December 2023 6.5 3.0 16.60 1.12 12.84 0.35 156 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Directors interest in shares (audited) continued Non-Executive Directors’ interests in shares The interests of the Non-Executive Directors in office during 2023 and their persons closely associated (PCA) are shown in the table below: Total directors’ interests as at(2) Prior NED share allocation plan Number of shares/ADS NED SOR 23 February 2024(1) 23 February 2024 31 December 2023 Beneficial interests at 31 December 2023(4) Dividends reinvested after year end 31 December 2023 Elected & allocated during the year(5) 1 January 2023 Shares Sir Jonathan Symonds Met 68,207 64,707 Wendy Becker In progress 478 478 Urs Rohner ADS Met 17,362 17,362 Elizabeth Anderson In progress 1,179 1,171 Charles Bancroft Met 23,564 22,809 64,707 478 17,362 1,171 7,005 Dr Hal Barron Dr Anne Beal Dr Hal Dietz Dr Jesse Goodman Vishal Sikka Met 641,269(3) 753,357 530,020 In progress In progress Met Met 2,821 2,605 14,120 4,454 2,734 2,527 13,548 4,422 934 934 934 4,422 — — — — 709 — 80 71 566 — — — — — 15,804 — 1,800 1,593 12,614 — 1,047 34,391 — 564 — 240 — 23 18 238 — — 18,519 — 15,564 — 1,777 1,575 12,375 — (1) NED Share Ownership Requirements: Since July 2022, the company has operated a minimum Non-Executive Director share ownership requirement (NED SOR) of at least one times the standard NED annual fee (or the Chair’s fee) to be maintained until after retirement. from the Board. The Chair and Non-Executive Directors have transitioned from the previous NED share allocation plan (NED Plan) to purchasing shares and ADSs in the market from their net fees. They all spend a minimum of 25% of their net fees in purchasing GSK shares or ADSs in the market (2) Total directors’ interests include beneficial interests and any notional shares/ADS received as all or part of their fees under the previously operated NED Plan. Dividends received on notional shares/ADS under the prior NED Plan during the year and in January 2024 were converted into notional shares/ADS as at 11 January 2024. For Dr Hal Barron, this includes the PSP award that vested in February 2024, see page 147 (3) The Total interests for Dr Barron have reduced since 31 December 2023 following the vesting of PSP and DABP awards granted to him in his former executive capacity as CSO. Details of the vesting level for the 2021 PSP is shown on page 147 and the DABP vest relates to the deferral of shares from the 2021 annual bonus. In addition, on vesting, shares are sold to meet an executive's tax liabilities. Details of his transition from CSO to a Non- Executive Director are given on page 135 of the 2022 Annual Report (4) Beneficial interests includes shares/ADS held by the Non-Executive Directors and their PCAs (5) Notional shares/ADS allocated during the year under the NED plan relates to dividends reinvested during the year 157 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Percentage change in remuneration of Directors 2023 percentage change 2022 percentage change 2021 percentage change 2020 percentage change Salary/ fees % Benefits % Bonus % Salary/ fees % Benefits % Bonus % Salary/ fees % Benefits % Bonus % Salary/ fees % Benefits % Bonus % 7.1 0.92 34.8 3.0 2.3 44.81 2.0 0.0 4.85 2.5 — 11.0 4.0 — 61.8 20.1 — — (2.2) 38.2 — — 2.0 — (5.0) 94.6 — — 8.0 — (26.6) (33.4) — — UK employees(1) Executive Directors(2,3) Emma Walmsley Julie Brown Non-Executive Directors(2,5) Sir Jonathan Symonds 5.0 200.0 Elizabeth McKee Anderson 209.3 — Charles Bancroft Dr Hal Barron(4) Dr Anne Beal Wendy Becker Dr Hal Dietz Dr Jesse Goodman Urs Rohner Dr Vishal Sikka Retired Executive Directors(2) Iain Mackay 2.8 180.0 127.1 609.1 2.7 — 126.7 — (3.4) 1900.0 (27.2) 12.6 131.0 41.9 73.9 — — — — — — — — — — — 3.0 — 0.0 — 233.3 — 36.7 100.0 — 121.7 — — 11.0 5.9 — — — — — 34.8 109.1 — — — — — — — — — — — 0.0 — 156.1 — — — — (5.6) (5.6) — 50.0 — — — — — — 0.0 175.0 — — — — — — — — — — — 201.7 0.0 — — — — — — — — — — — — (12.5) (65.2) 16.3 — (69.2) — — — — — — — — — — — (66.7) (71.8) (65.0) 3.0 20.2 32.4 2.0 56.1 94.2 5.6 (11.5) (31.6) (1) This table is provided in accordance with Schedule 8 of The Companies (Directors’ Remuneration Policy and Directors’ Remuneration Report) Regulations 2020. The UK employee population was considered to be the most relevant comparison as it most closely reflects the economic environment encountered by the Executive Directors (2) Percentage changes have been calculated based on the 2023 Total remuneration table on page 142 for Executive Directors and the 2023 Total fees table on page 155 for Non-Executive Directors (3) Further information on Executive Directors’ salary and benefits can be found on page 143 (4) Dr Hal Barron transitioned to a Non-Executive Director role on 1 August 2022 (5) Fees of Non-Executive Directors include fees received as cash and in the form of shares or ADS Directors and Senior Management Further information is provided on compensation and interests of Directors and Senior Management as a group (the group). For this purpose, the group is defined as the Executive and Non-Executive Directors, other members of the GLT and the Company Secretary. For the financial year 2023, the following table sets out aggregate remuneration for the group for the periods during which they served in that capacity. Remuneration for 2023 Total compensation paid Aggregate increase in accrued pension benefits (net of inflation) Aggregate payments to defined contribution schemes £ 37,406,891 6,403 1,314,332 During 2023, members of the group were awarded shares and ADS under the company’s various LTI plans, as set out in the table below. To align the interests of Senior Management with those of shareholders, Executive Directors and GLT members are required to build and maintain significant holdings of shares in GSK over time. GLT members are required to hold shares to an equivalent multiple of two times their base salary, and must continue to satisfy these share ownership requirements for a minimum of 12 months after leaving GSK. Awarded during 2023 Performance Share Plan Deferred Investment Awards(1,2) Share Value Plan(2) Shares 2,278,202 — 10,050 Awards ADS 64,427 — — Shares 258,760 11,694 — (1) Notional shares and ADS (2) Executive Directors are not eligible to receive Deferred Investment Awards or participate in the Share Value Plan Dividend reinvestment awards ADS 4,236 328 — 158 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Annual report on remuneration continued Directors and Senior Management continued At 23 February 2024, the group and their PCAs had the following interests in shares and ADS of the company. Interests awarded under the various LTI plans are described in Note 45 to the financial statements, ‘Employee share schemes’ on pages 260 to 261. Interests at 23 February 2024 Owned Unexercised options Deferred Annual Bonus Plan Performance Share Plan Deferred Investment Awards(1,2) Share Value Plan(2) Shares 3,444,022 3,988 1,179,129 7,256,570 146,847 44,738 ADS 558,102 — 76,130 299,940 4,668 — (1) Notional shares (2) Executive Directors are not eligible to receive Deferred Investment Awards or participate in the Share Value Plan Executive Directors’ external appointments The company recognises that Executive Directors may be invited to become non-executive directors of other companies. Such appointments can broaden their knowledge and experience to the benefit of the company. Executive Directors are entitled to retain any fees received from such appointments. Emma Walmsley is an independent non-executive director of Microsoft Corporation. During the year, whilst Iain Mackay was a Director of GSK, he was also an independent Non-Executive Director of National Grid plc. Service contracts and letters of appointment The table below sets out the dates of the Executive Directors’ service contracts, which are available at the company’s registered office and on gsk.com. Date of contract Effective date Expiry date Emma Walmsley 29.03.17 Julie Brown 25.09.22 01.04.17 01.05.23 30.06.34 n/a Non-Executive Directors have letters of appointment, which are also available to view at the company’s registered office. Each Non-Executive Director is expected to serve on the Board until the end of the AGM following the third anniversary of their appointment, provided that they are elected and subsequently re-elected annually. Subject to mutual agreement, they may serve a further one or two, three year terms, depending on the needs of the Board. How our Remuneration policy continues to reflect Provision 40 of the UK Corporate Governance Code (the Code) The company’s Remuneration policy was approved on 4 May 2022 at GSK’s Annual General Meeting and has operated as intended in terms of company performance and quantum since its approval. The full policy is available at gsk.com in the Investors section. Two administrative amendments were approved by shareholders at GSK's 2023 Annual General Meeting, as described on page 163 of the 2022 Annual Report. Clarity and simplicity: The remuneration arrangements for the Executive Directors are set out in a clear and simple way. Risk: We operate both deferral and post-vesting holding arrangements, in addition to operating malus and clawback provisions and the Committee has discretion to adjust the award outcomes. Predictability and proportionality: Our policy defines maximum limits on the total Annual bonus and Long-term incentive opportunities, and payouts under these elements are linked to fulfilment of performance conditions that support the company’s publicly stated ambitions and strategy. Alignment to culture: GSK’s purpose, strategy and culture continue to be directly reflected in the performance conditions set under the Annual Bonus and Long-term incentive. . 159 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Operation and scope of Remuneration policy (ii) before the Policy came into effect, provided that the terms of the payment were consistent with the shareholder-approved Remuneration policy in force at the time they were agreed; or (iii) at a time when the relevant individual was not a Director of the company and, in the opinion of the Committee, the payment was not in consideration for the individual becoming a Director of the company. For these purposes ‘payments’ includes the Committee satisfying awards of variable remuneration and, in relation to an award over shares or ADS, the terms of the payment are ‘agreed’ at the time the award is granted. Performance Share Plan (PSP) awards are subject to the terms of the PSP plan rules under which the award has been granted. The Committee may adjust or amend awards only in accordance with the provisions of the plan rules. This includes making adjustments to reflect one-off corporate events, such as a change in the company’s capital structure. The Committee may also make minor amendments to the Policy (for regulatory, exchange control, tax or administrative purposes or to take account of a change in legislation) without obtaining shareholder approval for such amendments. The Remuneration policy (Policy) is set out on pages 144 to 152 of the 2021 Annual Report, which is available in the Governance section at gsk.com. It is intended that the Policy for GSK’s Executive and Non-Executive Directors will operate for a period of three years from the date of approval at the company’s Annual General Meeting on 4 May 2022. The Committee wrote the Policy principally in relation to the remuneration arrangements for the Executive Directors, whilst taking into account the possible recruitment of a replacement or an additional Executive Director during the operation of the Policy. The Committee intends the Policy to operate for the period set out above in its entirety. However, it may after due consideration seek to change the Policy during this period, but only if it believes it is appropriate to do so for the long-term success of the company, after consultation with shareholders and having sought shareholder approval at a general meeting. The Committee reserves the right to make any remuneration payments and/or payments for loss of office (including exercising any discretions available to it in connection with such payments) notwithstanding that they are not in line with the Policy where the terms of the payment were agreed: (i) before the AGM on 7 May 2014 (the date the company’s first shareholder-approved Directors’ Remuneration policy came into effect); Basis of preparation The Annual report on remuneration has been prepared in accordance with the Companies Act 2006 and The Large and Medium-sized Companies and Groups (Accounts and Reports) (Amendment) Regulations 2013 (the Regulations). In accordance with the Regulations, the following parts of the Annual report on remuneration are subject to audit: total remuneration figures for Executive Directors including further details for each element of remuneration (salary, benefits, pension, Annual Bonus and Long-term incentive awards); Non- Executive Directors’ fees and emoluments received in the year; Directors’ interests in shares, including interests in GSK share plans; payments to past Directors; payments for loss of office; and share ownership requirements and holdings, for which the opinion thereon is expressed on page 179. The remaining sections of the Annual report on remuneration are not subject to audit nor are the pages referred to from within the audited sections. The Annual report on remuneration has been approved by the Board of Directors and signed on its behalf by: Urs Rohner Remuneration Committee Chair 27 February 2024 160 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Directors' report Directors' powers GSK Directors’ powers are determined by UK legislation and our Articles of Association, which contain rules about their appointment and replacement. They provide that Directors may be appointed by an ordinary resolution of the members or by a resolution of the Board. If appointed by the Board, the Director must retire at the next Annual General Meeting to be elected by shareholders Our Articles also provide that all Directors are required to seek re-election annually at our Annual General Meeting in accordance with the FRC's Code. A Director will then cease to be a Director if he or she: – becomes bankrupt – ceases to be a Director by virtue of the Companies Act or the Articles – suffers mental or physical ill health and the Board resolves that he or she shall cease to be a Director – has missed Directors’ meetings for a continuous period of six months without permission and the Board resolves that he or she shall cease to be a Director – is otherwise prohibited from being a Director by law – resigns, or offers to resign and the Board accepts that offer – is required to resign by the Board Directors’ conflicts of interest All Directors have a duty under the Companies Act 2006 to avoid a situation in which they have, or could have, a direct or indirect conflict of interest or possible conflict with the company. Our Articles provide a general power for the Board to authorise such conflicts. The Board reviews any new potential or actual conflict, which is recorded by the Company Secretary. Directors are not counted in the quorum for the authorisation of their own actual or potential conflicts. The Nominations & Corporate Governance Committee reviews the Register of Potential Conflicts on an annual basis which the Board subsequently approves. On a continuing basis, the Directors are responsible for informing the Company Secretary of any such new actual or potential conflicts that may arise or if there are any changes in circumstances that may affect an authorisation previously given. Even when provided with authorisation, a Director is not absolved from his or her statutory duty to promote the success of the company. If an actual conflict arises post-authorisation, the Board may choose to exclude the Director from receipt of the relevant information and participation in the debate, or suspend the Director from the Board, or, as a last resort, require the Director to resign. The Nominations & Corporate Governance Committee reviewed the Register of Potential Conflict authorisations (the Register of Potential Conflicts) in January 2024. The Committee reported to the Board that the conflicts had been appropriately authorised and that the process for authorisation continued to operate effectively. The Committee then recommended the approval of the Register of Potential Conflicts to the Board which it subsequently approved. Except as described in Note 40 to the financial statements, ‘Related party transactions’, during or at the end of the financial year no Director or Person Closely Associated had any material interest in any contract of significance with a Group company. Our Articles prohibit a Director from voting on any resolution concerning his or her appointment or the terms or termination of his or her appointment. Independent advice The company has an agreed procedure for Directors to take independent legal and/or financial advice at the company’s expense where they deem it necessary. Indemnification of Directors Qualifying third party indemnity provisions (as defined in the Companies Act 2006) are in force for the benefit of Directors and former Directors who held office during 2023 and up to the approval and signature of the Annual Report. Change of control and essential contracts We do not have contracts or other arrangements which individually are fundamental to the ability of the business to operate effectively. Neither is the company party to any material agreements that would take effect, be altered, or terminate upon a change of control following a takeover bid. We do not have agreements with any Director that would provide compensation for loss of office or employment resulting from a takeover, except that provisions of the company’s share plans may cause options and awards granted under such plans to vest on a takeover. Details of the termination provisions in the Executive Directors’ service contracts are given in the full version of the company’s 2022 Remuneration policy which is available on gsk.com in the Investors section. Content of the Directors’ report For the purposes of the UK Companies Act 2006, the Directors’ report of GSK plc for the year ended 31 December 2023 comprises: Directors’ report Section Corporate governance report Employee engagement Directors’ statements of responsibilities Investor information Pages 108 to 162 121 165 and 166 273 and 314 The Strategic report sets out those matters required to be disclosed in the Directors’ report which are considered to be of strategic importance: Strategic report Section Risk management objectives and policies Likely future developments of the company Research and development activities Business relationships Diversity Provision of information to and consultations with employees Carbon emissions Section 172 statement Pages 57 to 76 and 284 to 294 1 to 106 16 to 30 46 to 55 52 and 53 14, 15, 52 and 53 49 to 52 123 to 127 161 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Directors' report continued The following information is also incorporated into the Directors’ report: Interest capitalised Particulars of important post-balance sheet events of the company or its subsidiaries Publication of unaudited financial information Details of any long-term incentive schemes Location in Annual Report Financial statements, Notes 17 and 20 Financial statements, Note 48 Group financial review Remuneration report Waiver of emoluments by a Director Not applicable Waiver of future emoluments by a Director Not applicable Non pre-emptive issues of equity for cash Not applicable Non pre-emptive issues of equity for cash by any unlisted major subsidiary undertaking Not applicable Parent company participation in a placing by a listed subsidiary Not applicable Provision of services by a controlling shareholder Not applicable Shareholder waiver of dividends Shareholder waiver of future dividends Financial statements, Notes 16 and 45 Financial statements, Notes 16 and 45 Agreements with controlling shareholders Not applicable The Directors’ report – has been drawn up and presented in accordance with and in reliance upon English company law and the liabilities of the Directors in connection with that Report shall be subject to the limitations and restrictions provided by such law. – was approved by the Board of Directors on 27 February 2024 and signed on its behalf by: Sir Jonathan Symonds Chair 27 February 2024 162 Financial statements In this section Directors’ statement of responsibilities Independent Auditor’s report Financial statements Notes to the financial statements Financial statements of GSK plc prepared under UK GAAP 164 166 180 184 267 GSK Annual Report 2023 163 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Directors' statement of responsibilities The Directors are responsible for preparing the Annual Report, the Remuneration report and the Group and parent company financial statements in accordance with applicable law and regulations. UK company law requires the Directors to prepare financial statements for each financial year. The Directors are required to prepare the Group consolidated financial statements in accordance with UK-adopted international accounting standards in conformity with the requirements of the Companies Act 2006 and the International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB). The Directors have elected to prepare the parent company financial statements in accordance with United Kingdom Accounting Standards and applicable law (United Kingdom Generally Accepted Accounting Practice) (Financial Reporting Standard 101 Reduced Disclosure Framework). Under company law the Directors must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the Group and its profit or loss for that period. In preparing the financial statements, the Directors are required to: – select suitable accounting policies and then apply them consistently; – make judgements and accounting estimates that are reasonable and prudent; – state that the Group financial statements comply with IFRS, as issued by the IASB and in conformity with the requirements of the Companies Act 2006; – state with regard to the parent company financial statements that applicable UK Accounting Standards have been followed, subject to any material departures disclosed and explained in the parent company financial statements; and – prepare the financial statements on a going concern basis unless it is inappropriate to presume that the Group and the parent company will continue in business. In preparing the Group financial statements, International Accounting Standard 1 requires that directors properly select and apply accounting policies; present information, including accounting policies, in a manner that provides relevant, reliable, comparable and understandable information; provide additional disclosures when compliance with the specific requirements in IFRS Standards are insufficient to enable users to understand the impact of particular transactions, other events and conditions on the entity’s financial position and financial performance; and make an assessment of the company’s ability to continue as a going concern. The Directors are responsible for keeping adequate accounting records that are sufficient to show and explain the company’s transactions and disclose with reasonable accuracy at any time the financial position of the Group and to enable them to ensure that the Group financial statements and the Remuneration report comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the Group and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. The Group financial statements for the year ended 31 December 2023, comprising principal statements and supporting notes, are set out in the ‘Financial statements’ on pages 180 to 266 of this report. The parent company financial statements for the year ended 31 December 2023, comprising the balance sheet and the statement of changes in equity for the year ended 31 December 2023 and supporting notes, are set out on pages 267 to 271. The responsibilities of the auditor in relation to the financial statements are set out in the Independent Auditor’s report on pages 166 to 179. The financial statements for the year ended 31 December 2023 are included in the Annual Report, which is published in printed form and made available on our website. The Directors are responsible for the maintenance and integrity of the corporate and financial information included on the company’s website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions. Each of the current Directors, whose names and functions are listed in the Corporate Governance section of the Annual Report 2023 confirms that, to the best of his or her knowledge: – the Group financial statements, which have been prepared in accordance with the applicable set of accounting standards and in conformity with the requirements of Companies Act 2006, give a true and fair view of the assets, liabilities, financial position and profit of the Group; – the strategic report and risk sections of the Annual Report, which represent the management report, include a fair review of the development and performance of the business and the position of the company and the Group taken as a whole, together with a description of the principal risks and uncertainties that it faces; and – the Annual Report and financial statement, taken as a whole, are fair, balanced and understandable and provide the information necessary for shareholders to assess the company’s position and performance, business model and strategy. 164 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Directors' statement of responsibilities continued Disclosure of information to auditor The Directors in office at the date of this Annual Report have each confirmed that: – so far as he or she is aware, there is no relevant audit information of which the company’s auditor is unaware; and – he or she has taken all the steps that he or she ought to have taken as a Director to make himself or herself aware of any relevant audit information and to establish that the company’s auditor is aware of that information. This confirmation is given and should be interpreted in accordance with the provisions of section 418 of the Companies Act 2006. Going concern basis Pages 78 to 106 and pages 62 to 69 contain information on the performance of the Group, its financial position, cash flows, net debt position, borrowing facilities and climate related risks. Further information, including Treasury risk management policies, exposures to market and credit risk and hedging activities, is given in Note 44, 'Financial instruments, and related disclosures' to the financial statements. Having assessed the principal risks and other matters considered in connection with the viability statement, the Directors considered it appropriate to adopt the going concern basis of accounting in preparing the financial statements. Internal control The Board, through the Audit & Risk Committee, has reviewed the assessment of risks and the internal control framework that operates in GSK and has considered the effectiveness of the system of internal control in operation in the Group for the year covered by this Annual Report and up to the date of its approval by the Board of Directors. Further detail on the review of internal controls is set out in the Governance report on page 134. The 2018 UK Corporate Governance Code The Board considers that GSK plc applies the principles and complies with the provisions of the UK Corporate Governance Code maintained by the Financial Reporting Council, as described in the Corporate Governance section on pages 118 to 138. The Board further considers that the Annual Report, taken as a whole, is fair, balanced and understandable, and provides the information necessary for shareholders to assess the Group’s position and performance, business model and strategy. As required by the Financial Conduct Authority’s Listing Rules, the auditor has considered the Directors’ statement of compliance in relation to those points of the UK Corporate Governance Code which are specified for their review. Annual Report The Annual Report for the year ended 31 December 2023, comprising the Report of the Directors, the Remuneration report, the Financial statements and Additional information for investors, has been approved by the Board of Directors and signed on its behalf by Sir Jonathan Symonds Chair 27 February 2024 165 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report to the members of GSK plc Report on the audit of the financial statements 1. Opinion In our opinion: – The financial statements of GSK plc (the ‘Parent company’) and its subsidiaries (the ‘Group’) give a true and fair view of the state of the Group’s and of the Parent company’s affairs as at 31 December 2023 and of the Group’s profit for the year then ended; – The Group financial statements have been properly prepared in accordance with United Kingdom adopted international accounting standards and International Financial Reporting Standards (IFRSs) as issued by the International Accounting Standards Board (IASB); – The Parent company financial statements have been properly prepared in accordance with United Kingdom Generally Accepted Accounting Practice including FRS 101 “Reduced Disclosure Framework”; and – The financial statements have been prepared in accordance with the requirements of the Companies Act 2006. We have audited the financial statements which comprise the Group – Consolidated balance sheet as at 31 December 2023; – Consolidated income statement for the year then ended; – Consolidated statement of comprehensive income for the year then ended; – Consolidated statement of changes in equity for the year then ended; – Consolidated cash flow statement for the year then ended; and – Notes 1 to 48 to the financial statements, which includes the material accounting policy information. 2. Basis for opinion We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the auditor’s responsibilities for the audit of the financial statements section of our report. We are independent of the Group and the Parent company in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the Financial Reporting Council’s (the ‘FRC’s’) Ethical Standard as applied to listed public interest entities, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We confirm that we have not provided any non- audit services prohibited by the FRC’s Ethical Standard to the Group or the Parent company, as noted in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report on page 133 and the disclosure provided in Note 8 regarding fees payable to the Group’s auditor. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. 3. Summary of our audit approach Key audit matters The key audit matters that we identified in the current year were: – Valuation of the ViiV Healthcare Shionogi contingent consideration liability – Valuation of US Returns and Rebates (RAR) accruals – Valuation of other intangible assets – Valuation of uncertain tax positions, including transfer pricing Parent company – Valuation of the contingent liabilities and significant legal – Balance sheet as at 31 December 2023; – Statement of changes in equity for the year then ended; and – Notes A to L to the financial statements, which includes the material accounting policy information. The financial reporting framework that has been applied in the preparation of the Group financial statements is applicable law, United Kingdom adopted international accounting standards and IFRSs as issued by the IASB. The financial reporting framework that has been applied in the preparation of the Parent company financial statements is applicable law and United Kingdom Accounting Standards, including FRS 101 “Reduced Disclosure Framework” (United Kingdom Generally Accepted Accounting Practice). proceedings. Materiality – The materiality that we used for the group financial statement was £280 million (2022: £210 million) which was determined on the basis of Statutory profit before tax, Adjusted profit before tax, Revenue and Net cash flows from operations. Scoping – The following components were subject to audit procedures as well as the assessment of the effectiveness of internal controls over financial reporting: Belgium, Canada, China, France, Germany, Italy, Japan, United Kingdom and the United States. Our audit scope addressed 80% (2022: 79%) of the Group’s revenue, 92% (2022: 91%) of the Group’s profit before tax and 76% (2022: 86%) of the Group’s total assets. Significant changes in our approach – We have removed the key audit matters relating to the Consumer Healthcare demerger and IT systems that impact financial reporting. 166 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued 4. Conclusions relating to going concern 5. Key audit matters Key audit matters are those matters that, in our professional judgement, were of most significance in our audit of the financial statements of the current period and include the most significant assessed risks of material misstatement (whether or not due to fraud) that we identified. These matters included those which had the greatest effect on the overall audit strategy, the allocation of resources in the audit and directing the efforts of the engagement team. These matters were addressed in the context of our audit of the financial statements as a whole, and in forming our opinion on the financial statements as a whole, we do not provide a separate opinion on these matters. We have removed two key audit matters in 2023; the Consumer Healthcare Demerger key audit matter following the completion of the demerger in the prior year, and the key audit matter relating to IT systems that impact financial reporting following the remediation of control deficiencies relating to governance and operation of infrastructure privileged access management in the prior year. In auditing the financial statements, we have concluded that the directors’ use of the going concern basis of accounting in the preparation of the financial statements is appropriate. Our evaluation of the directors’ assessment of the Group’s and Parent company’s ability to continue to adopt the going concern basis of accounting included: – Enquiries of the Group directors and management regarding the assumptions used in the going concern models, including the potential impact of climate change; – Evaluating the Group’s existing access to sources of financing, including undrawn committed bank facilities, including the impact of changes in interest rates on profitability; – Reading analyst reports, industry data and other external information, including understanding the macroeconomic environment, to determine if it provided corroborative or contradictory evidence in relation to assumptions used; – Comparing forecasted sales to recent historical financial information; – Testing the underlying data generated to prepare the forecast scenarios and determined whether there was adequate support for the assumptions underlying the forecast; and – Evaluating the Group’s disclosures on going concern against the requirements of IAS 1. Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the Group’s and Parent company’s ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue. In relation to the reporting on how the Group has applied the UK Corporate Governance Code, we have nothing material to add or draw attention to in relation to the Directors’ statement in the financial statements about whether the Directors considered it appropriate to adopt the going concern basis of accounting. Our responsibilities and the responsibilities of the Directors with respect to going concern are described in the relevant sections of this report. 167 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued Key audit matter description How the scope of our audit responded to the key audit matter Valuation of the ViiV Healthcare Shionogi contingent consideration liability The Group has completed a number of significant transactions which resulted in the recognition of material contingent consideration liabilities, which are a key source of estimation uncertainty. The most significant of these liabilities was the ViiV Healthcare Shionogi Contingent Consideration Liability (ViiV CCL). The Group completed the acquisition of the remaining 50% interest in the Shionogi-ViiV Healthcare joint venture in 2012. Upon completion, the Group recognised a contingent consideration liability for the fair value of the expected future payments to be made to Shionogi. As at 31 December 2023 the liability was valued at £5,718 million. We identified the ViiV CCL as a key audit matter because of the significant estimates and assumptions relating to the sales forecasts used in valuing the ViiV CCL and the sensitivity of the valuation to these inputs. The most significant of these relate to sales forecasts in the United States (US) on certain products in the treatment and prevention portfolio. Such forecasts are based on an assessment of the expected launch dates for pipeline assets, the ability to shift market practice and prescriber behaviour towards long-acting injectable treatments and 2-drug regimens, the size of long-acting prevention market and subsequent sales volumes. There is incremental challenge in forecasting sales associated with recently launched products due to the lack of historical actual data. The sales forecasts also required significant audit effort to perform appropriate audit procedures to challenge and evaluate the reasonableness of those forecasts. Contingent consideration liabilities, including the ViiV CCL, are disclosed as a key source of estimation uncertainty in Note 3, of the Group financial statements with further disclosures provided in Note 33. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report. Audit procedures performed We performed the following audit procedures, amongst others, related primarily to the sales forecasts: – Tested the controls over the key inputs and assumptions used in the valuation of the contingent consideration liability, including review controls over the sales forecasts of the treatment product portfolio used to value the ViiV CCL; – Obtained the Group’s assessment of the key inputs and assumptions used in the sales forecasts and challenged the reasonableness of these, including through enquiries of key individuals from the senior leadership team, commercial strategy team and key personnel involved in the budgeting and forecasting process, and inspection of supporting evidence; – Challenged the US volume assumptions made by the Group to estimate sales forecasts. This involved benchmarking forecast market share data against external data, such as total prescription volumes and new patient prescription volumes, in order to assess for any sources of contradictory evidence; – Challenged the reasonableness of US pricing assumptions by the Group, by comparing the forecasted Returns and Rebates rate by product against the current rate, and assessing the forecasted Returns and Rebates against comparable products considering expected changes in payer policy; – Considered the results of clinical studies undertaken in the year by the Group and key competitors in order to assess whether these are corroborative or contradictory to assumptions used in the product portfolio sales forecasts in the US; – Benchmarked the Group’s sales forecasts against those included in reports from nine analysts and considered sales forecasts on both a total ViiV basis and an individual product basis, assessing against identified contradictory data; and – Together with our valuations specialists, assessed the reasonableness of the overall valuation methodology, including benchmarking the discount rate used and testing the valuation model for mechanical accuracy. Key observations communicated to the Audit & Risk Committee The sales forecasts used in the valuation are reasonable and in line with relevant supporting information. We are satisfied that the sales forecasts appropriately reflect trends in the overall HIV treatment and prevention markets including the impacts of competition, healthcare reform and a predicted shift towards long-acting injectable products. The approach to valuing the ViiV CCL was consistent with prior periods and overall we are satisfied that the valuation liability is reasonable and consistent with IFRS. 168 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued Key audit matter description How the scope of our audit responded to the key audit matter Valuation of US Returns and Rebates (RAR) accruals Audit procedures performed We performed the following audit procedures, amongst others, related to estimates in the RAR accruals: – Tested the key controls over the estimation of RAR accruals including the controls associated with the forecasting of utilisation rates process and the month-end accrual review controls; – Challenged assumptions for a selection of utilisation rates, focusing on certain products where we concluded the accrual is most sensitive to these assumptions. Our challenge included comparison to historical utilisation rates, consideration of historical accuracy and assessment of how market changes such as the impact of competition, new product launches, changes in government legislation and macroeconomic factors are appropriately reflected in the RAR accruals; – Supplemented this with substantive analytical procedures by developing an independent expectation of the accrual balance for each of the key segments, based on historical claims received adjusted to reflect market changes in the period including an assessment of the time lag between the initial point of sale and the claim receipt. We then compared this independent expectation to those recorded to evaluate the appropriateness of the year ending accrual position; – Considered the historical accuracy of estimates and evaluated whether forecast assumptions had been appropriately updated in a selection of cases where the actual rebate claims differed to the amount accrued; – Evaluated the appropriateness of, and completeness of, period-end adjustments to the liability made as part of the ongoing review of the estimated accrual; and – Performed audit procedures over the actual rebate payments made in the year by agreeing to the relevant contract to assess whether the rebate payments were in line with the contractual terms. Key observations communicated to the Audit & Risk Committee We are satisfied that the estimated liability of the RAR accruals at the year-end is appropriate. We observed a level of prudence in the estimate when assessing against our own independent expectations, which is in accordance with the requirements of IFRS 15 Revenue from contracts with customers to limit the risk of a significant reversal of revenue. In the US, the Group sells to customers under various commercial and government mandated contracts and reimbursement arrangements that include rebates, chargebacks and a right of return for certain pharmaceutical products. As such, revenue recognition reflects gross-to-net sales adjustments. These adjustments are known as the Returns and Rebates (RAR) accruals and are a source of significant estimation uncertainty which could have a material impact on reported revenue. In the US Commercial business in 2023, £16,539 million of RAR deductions were made to gross revenue of £32,359 million, resulting in net revenue of £15,820 million. The balance sheet accrual at 31 December 2023 for the US Commercial business amounted to £5,951 million. The four most significant payer channels (also referred to as buying groups) to which the RAR accrual relates are managed healthcare organisations, Medicaid, Ryan White and Medicare Part D. The two main causes of significant estimation uncertainty are: – The utilisation rate, which is the portion of total sales that will be made into each payer channel, estimated in recording the accruals. The utilisation assumption is the most challenging of the key assumptions used to derive the accrual given that it is influenced by market demand and other factors outside the control of the Group; and – The time lag between the point of sale and the point at which exact rebate amounts are known to the Group upon receipt of a claim. Those payer channels with the longest time lag result in a greater accrued period, and therefore, a greater level of estimation uncertainty in estimating the period-end accrual. The level of estimation uncertainty is also impacted by significant shifts in channel mix driven by changes in the competitive landscape, including competitor and generic product launches, changes in government legislation and other macroeconomic factors. As such, we focus on the utilisation assumptions for those products where we deem the level of estimation uncertainty to be the most significant. We also focus on the period-end adjustments made to the RAR accruals. These adjustments reflected updates made to the initial assumptions included within the forecasted RAR rates and, in our view, present the greatest opportunity for fraud in revenue recognition (notwithstanding the existence of internal controls). US Commercial Operations returns and rebates are disclosed as a key source of estimation uncertainty in Note 3 of the Group financial statements with further disclosures provided in Note 29. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report. 169 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued Key audit matter description Valuation of other intangible assets How the scope of our audit responded to the key audit matter Audit procedures performed As at 31 December 2023, the Group held £14,166 million of other intangible assets (including licenses, patents, trademarks, and trade names, but excluding goodwill and computer software). This includes £1,438 million of intangible assets acquired as part of the acquisition of Bellus Health during the year. We performed the following audit procedures, amongst others, over the forecast sales pricing, volume, growth rates, probability of technical and regulatory success, profit margin levels, and discount rates used in the assessment of the valuation of other intangible assets, such as those acquired as part of the Group’s acquisition of Bellus Health: Intangible assets which are in-development and not available for use should be tested at least annually for impairment irrespective of whether an indication of impairment exists. When the carrying amount of an individual intangible asset, or an cash-generating unit to which an intangible asset belongs, exceeds its recoverable amount, an impairment occurs. Recoverability of an intangible asset is derived from certain assumptions and estimates of future trading performance which create significant estimation uncertainty. The underlying assumptions include forecast sales pricing, volume, growth rates and probability of technical and regulatory success of ongoing clinical trials. This includes assumptions on timing of cash flows determined by anticipated launch year, peak year sales, subsequent sales erosion due to generic product competition and profit margin levels. In addition, due to the impact of uncertainty driven by ongoing global macroeconomic volatility, the valuation of intangible assets will also be affected by discount rate assumptions made by the Group. During 2023, impairment charges of £398 million were recorded. These were primarily full impairments due to cessation of research and development dictated by negative clinical trial readouts or lack of commercial attractiveness. We identified the valuation of other intangible assets as a key audit matter due to the inherent judgements involved in estimating future cash flows. Auditing such assumptions and estimates required extensive audit effort to challenge and evaluate the reasonableness of forecasts and management judgements. The disclosures relating to other intangible assets, including those acquired as part of business combinations, are included in Note 20 and Note 41 of the Group financial statements. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report. . – Tested review controls over the key inputs and assumptions used in the valuation of other intangible assets. The controls encompass review of the valuation models, which contain a number of assumptions such as the probability of technical and regulatory success, launch dates plus other revenue and cost assumptions; – Inquired with key individuals from the corporate development team, commercial forecasting leads, and key personnel involved in the assets research and development process. We used the outcome of these inquiries to evaluate the Group’s evidence to support key assumptions such as overall sales forecasts, peak year sales (including anticipated market share, volume and uptake alongside price points where required), foreseeable competitive landscape, growth rates, probability of regulatory and technical success and margins; – Evaluated the key inputs and assumptions applied in estimating sales and profit margin forecasts, including benchmarking of forecasts against external market data. This included independent market research of therapeutic area price points, price growth rates, and anticipated competitor market landscape, currently and at the time of forecast regulatory approval, plus assessment of any sources of contradictory evidence; – Compared the forecast sales and profit margin levels to the Plan data (asset by asset internal forecasts) approved by the GSK Leadership Team and the Board of Directors, where the in-development intangible asset is forecast to launch within the next 3-year period; – Assessed the historical accuracy of sales forecasts by performing retrospective reviews across marketed assets within the business; – Engaged our fair valuation specialists to assess the reasonableness of discount rates and valuation methodology applied as well as performing mechanical accuracy checks; and – Considered whether events or transactions that occurred after the balance sheet date, but before the reporting date, affect the conclusions reached on the carrying values of the assets and associated disclosures. Key observations communicated to the Audit & Risk Committee For those intangible assets which were acquired during the period as part of the Bellus Health business acquisition we concluded that the assumptions underpinning the fair value of intangible assets reflected in the purchase price allocations were reasonable and in accordance with IFRS. For those intangible assets in-development and subject to impairment reviews we concluded that the judgements made by management were reasonable and in accordance with IFRS. 170 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued Key audit matter description How the scope of our audit responded to the key audit matter Valuation of uncertain tax positions, including transfer pricing Audit procedures performed The Group operates in numerous jurisdictions and there are open tax and transfer pricing matters and exposures with UK, US and overseas tax authorities that give rise to uncertain tax positions. There is a wide range of possible outcomes for provisions and contingencies. Certain judgements in respect of estimates of tax exposures and contingencies are required in order to assess the adequacy of tax provisions, which are sometimes complex as a result of the considerations required over multiple tax laws and regulations. At 31 December 2023, the Group has recorded provisions of £584 million in respect of uncertain tax positions. Valuation of uncertain tax positions is disclosed as a key source of estimation uncertainty in Note 3 of the Group financial statements with further disclosures included in Note 14. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report. With the support of our tax specialists, we assessed the appropriateness of the uncertain tax provisions, focused on those jurisdictions where the Group has the greatest potential exposure and where the highest level of judgement is required, by performing the following audit procedures amongst others: – Tested key controls over preparation, review and reporting of judgmental tax balances and transactions, which include provisions for uncertain tax provisions; – Assessed the assumptions and judgements that are required to determine the range of possible outcomes for recognition and measurement of provisions for uncertain tax positions in compliance with the requirements of IFRIC 23 Uncertainty over Income Tax Treatments; – Involved our transfer pricing specialists to evaluate the transfer pricing methodology of the Group and associated approach to provision recognition and measurement; and – Considered evidence such as the actual results from the recent tax authority audits and enquiries, third-party tax advice obtained by the Group and our tax specialists’ own knowledge of market practice in relevant jurisdictions. Key observations communicated to the Audit & Risk Committee We are satisfied that the estimates in relation to uncertain tax positions and the related disclosures are in accordance with IFRS. From our work we concluded that a consistent approach has been applied to estimating uncertain tax provisions which is appropriate and in accordance with IFRIC 23. 171 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued Key audit matter description How the scope of our audit responded to the key audit matter Valuation of the contingent liabilities and significant legal proceedings Audit procedures performed We performed the following audit procedures: The Group operates in an environment where it is subject to significant legal and administrative proceedings, including product liability, intellectual property, tax, anti-trust, consumer fraud and governmental regulations. The Group is currently exposed to a number of regulatory and litigation matters. The Group’s provision for these matters is £267 million at 31 December 2023. Other matters are disclosed as contingent liabilities where the criteria for recognising a provision under IAS 37 Provisions, Contingent Liabilities and Contingent Assets are not met, including the Zantac litigation described in Note 47. Significant judgement is required by the Group in determining whether, under IAS 37 Provisions, Contingent Liabilities and Contingent Assets, in particular in relation to the Zantac litigation, as to: – Whether the outcome will result in a probable outflow, particularly where the outcome of litigation is uncertain and subject to additional court proceedings; – The determination of a reliable estimate can be made of the amounts of the obligation; and – The nature and extent of any contingent liabilities and underlying significant estimation uncertainties disclosed. Contingent liabilities and significant legal proceedings are disclosed in Notes 35 and 47, respectively. The key audit matter is discussed within the Corporate Governance section of the Annual Report. – Tested the Group’s controls over the completeness of provisions, the robustness of the provision against the requirements of IAS 37, the appropriateness of judgements used to determine a ‘best estimate’ and completeness and accuracy of data used in the process; – Evaluated the assessment of the provisions, associated probabilities, and potential outcomes in accordance with IAS 37; – Evaluated the methodology, data and significant judgements and assumptions used in the valuation of the provisions are appropriate in the context of the applicable financial reporting framework; – Inquired with and inspected correspondence from the Group’s internal and external counsel to assess the litigation matter and evaluate the Group’s significant judgements and assumptions; – Where no provision was made for actual or expected trial outcomes or settlements, evaluated the Group’s conclusion, supportive and contradictory evidence and the requirements of IAS 37, particularly with respect to the Zantac litigation; – Read board minutes and settlement agreements to evaluate management’s approach in respect of the litigation, and agreed the terms and conditions of such arrangements to the payments made to evaluate provisions already recorded and whether there is a requirement for additional provisions; – In respect of the Zantac litigation, inspected the evidence presented in relevant scientific studies and the outcomes of other product liability litigation in the same jurisdictions alongside the entity’s assessment of possible outcomes of each ongoing trial and expectation of which trials will go ahead as per the schedule of future trials; and – Evaluated whether the disclosures made in the financial statements appropriately reflect the facts and critical accounting judgements. Key observations communicated to the Audit & Risk Committee We are satisfied that the estimation of the provisions and contingent liability disclosures are consistent with the requirements of IAS 37. 172 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued 6 Our application of materiality We define materiality as the magnitude of misstatement in the financial statements that makes it probable that the economic decisions of a reasonably knowledgeable person would be changed or influenced. We use materiality both in planning the scope of our audit work and in evaluating the results of our work. Based on our professional judgement, we determined materiality for the financial statements as a whole as follows: Group financial statements Materiality £280 million (2022: £210 million) Parent company financial statements £280 million (2022: £52.5 million) Basis for determining materiality In determining our benchmark for materiality, we considered the metrics used by investors and other readers of the financial statements. In particular, we considered: Statutory profit before tax, Adjusted profit before tax, Revenue and Net cash flows from operations. Materiality was determined using the total assets benchmark capped at 100% (2022: 25%) of Group materiality. Our materiality represents 0.62% of total assets. Using professional judgement, we have determined materiality to be £280 million. See below for how our materiality compares to our benchmark metrics. Metric % Statutory profit before tax 4.62% Adjusted profit before tax* 3.45% Revenue Net cash inflow from operating activities 0.92% 4.14% * A reconciliation between the Statutory profit before tax and Adjusted profit before tax is detailed in the Adjusting Items section of the strategic report. Given the importance of the above metrics used by investors and other readers of the financial statements, we concluded `Statutory profit before tax` to be the primary benchmark. The adjusted profit before tax, Revenue and Net cash inflow from operating activities, have been used as supporting benchmarks. The component materiality allocated to the in-scope components ranged between £66 million and £196 million (2022: between £40 million and £125 million). Rationale for the benchmark applied The strength of the balance sheet is the key measure of financial health that is important to shareholders since the primary concern for the Parent company is the payment of dividends. Using a benchmark of total assets is therefore the appropriate metric. The current year materiality has been increased to reflect the size, scale and nature of the Parent company. Where account balances are audited for the purpose of the consolidated financial statements, a lower component materiality is used. We set performance materiality at a level lower than materiality to reduce the probability that, in aggregate, uncorrected and undetected misstatements exceed the materiality for the financial statements as a whole. Group and Parent company performance materiality was set at 70% of Group and Parent materiality respectively for the 2023 audit (2022:70%). In determining performance materiality, we considered factors including: – Our risk assessment, including our assessment of the Group’s overall control environment and that we consider it appropriate to rely on controls over a number of business processes; and – Our past experience of the audit, which has indicated a low number of corrected and uncorrected misstatements identified in prior periods. We agreed with the Audit & Risk Committee that we would report to the Committee all audit differences in excess of £10 million (2022: £10 million) as well as any differences below this threshold, which in our view, warranted reporting on qualitative grounds. We also report to the Audit & Risk Committee on disclosure matters that we identified when assessing the overall presentation of the financial statements. 173 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued 7. Audit scope and execution We structured our approach to the audit to reflect how the Group is organised and ensured our audit was both effective and risk focused. The central control and common systems throughout the Group enables us to deploy and utilise technology and data analytics across the breadth of the Group, enabling a more detailed understanding of the flow of transactions, enabling us to focus our risk assessment and design targeted audit testing procedures. We embed technology throughout our audit to improve quality and effectiveness, including in the areas of planning and scoping, project management, risks and controls assessment, substantive testing and reporting insights to management and the Audit and Risk Committee. We have piloted the use of artificial intelligence powered tools as we continue to invest in our use of technology across the audit. Our audit approach can be summarised into the following areas that enabled us to obtain the evidence required to form an opinion on the Group and Parent company financial statements: – Risk assessment and audit planning at a Group level. Our risk assessment procedures considered, amongst other factors, the impact of climate change and the wider macroeconomic environment on the account balances, disclosures and company practices. Our data analytical tools allow us to scrutinise large transactional data sets for unusual trends, characteristics, outliers or transaction flows to support our identification of audit risks. For example, we analysed US RAR data by product and payment channel to identify products where there are high values of total rebate deductions recognised, where there are significant differences on rebate rates offered between payers or where qualitative factors impacted the brands (see Section 5 - Valuation of US Returns and Rebates (RAR) accruals). We also used data analytics to determine products and regions where the valuation of the ViiV Healthcare Shionogi contingent consideration liability was most sensitive to the assumptions used (see Section 5 - Valuation of the ViiV Healthcare Shionogi contingent consideration liability). We appointed partners from the Group audit team to lead the global audit of the operating segments (commercial operations and research & development), in addition to partners responsible for the component and legal entity audits in each country. These segment partners met regularly with senior segment management to understand the strategy, performance and other matters which arose throughout the year that could have impacted the financial reporting. In addition, we held regular meetings with members of the Internal Audit, the internal Legal Counsel and the Global Ethics & Compliance teams to understand their work and to review their reports to enhance our risk assessment; – Audit work performed at global shared service centres A significant amount of the Group’s operational processes that cover financial reporting is undertaken in shared service centres. Our Group audit team included senior individuals responsible for each of the global processes who coordinated our audit work at the shared service centres utilising a live global project management platform. This structure enables us to develop a good understanding of the end-to-end processes that supported material account balances, classes of transactions and disclosures within the Group financial statements. We then evaluated the effectiveness of internal controls over financial reporting for these processes and considered the implications for the remainder of our audit work; – Audit work executed at component level and individual legal entities. The following components were subject to audit procedures as well as the assessment of the effectiveness of internal controls over financial reporting: Belgium, Canada, China; France, Germany, Italy, Japan, United Kingdom and the United States. The Group audit team was in active dialogue throughout the audit with the component audit teams responsible for the audit work under the direction and supervision of the Group audit team. This included determining whether the work was planned and performed in accordance with the overall Group audit strategy and the requirements of our Group audit instructions to the components. As part of supervising the work of the components, senior Group audit team members visited Belgium, USA, UK and China, as well as the shared service centre audits for Malaysia and Poland. To satisfy ourselves that our oversight and supervision was appropriate we performed reviews of audit working papers, increased the frequency and length of those reviews depending on the significance and risk of the component and continued to attend the planning and clearance meetings of components; – Audit procedures undertaken at a Group level and on the parent company. In addition to the above, we also performed audit work on the Group and Parent company financial statements, including but not limited to the consolidation of the Group’s results, the preparation of the financial statements, certain disclosures within the Directors’ Remuneration report, litigation provisions and exposures in addition to entity level and oversight controls relevant to financial reporting. All components or legal entities with annual revenue greater than 1.8% (2022:1.8%) of the total Group revenue were included in our audit scope. The components or legal entities not covered by our audit scope were subject to analytical procedures confirming that there were no significant risks of material misstatement in the aggregated financial information; and – Internal controls testing approach. We tested the effectiveness of internal controls over financial reporting across all in-scope entities and entity level controls at the Group level. Common systems allowed for relevant IT controls to be tested centrally across all components and we utilised an automated controls testing tool which was leveraged to support our testing of both IT controls and automated business controls. We were able to place reliance on controls where planned. Our audit scope addressed 80% (2022:79%) of the Group's revenue, 92% (2022: 91%) of the Group's profit before tax and 76% (2022: 86%) of the Group's total assets. 174 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued The impact of climate change on our audit In consultation with our climate change specialists, we: Climate change has the potential to impact the Group in a number of ways as set out in the strategic report on pages 62 to 70 of the Annual Report and Notes 17, 19 and 20 on pages 207, 209 and 210 of the financial statements. The Group has committed to net zero greenhouse gas emissions across the Group’s full value chain by 2045. In the planning of our audit, we have considered the potential impact of climate change on the Group’s business and its financial statements. – Conducted detailed risk assessment procedures across all in- scope balances and transactions to determine any risks of material misstatement in the financial statements by applying the expected impact of climate change to our understanding of the business; – Challenged the appropriateness of the Group’s assessment of the potential impact of climate change and the impact of these on the financial statements, including in the area of intangible assets; and We have sought to understand the Group’s identification and assessment of the potential impacts of climate change, how these risks influence the Group’s strategy and their implications on the financial statements. – Used our own assessment of the impact of climate change to challenge the Group’s assessment of going concern, including considering the potential impact on future performance and availability of financing. The Group’s assessment focused on the impacts of more frequent extreme weather conditions, water scarcity, changes in the political landscape and media focus which has the propensity to cause changes in consumer and market behaviour; volatility in the costs and availability of materials and resources that could impact future financial performance and asset valuations. As part of our audit procedures, we are required to read and consider these disclosures to consider whether they are materially inconsistent with the financial statements or knowledge obtained in the audit. We did not identify any material inconsistencies as a result of these procedures. 175 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued 8. Other information The other information comprises the information included in the Annual Report, other than the financial statements and our auditor’s report thereon. The Directors are responsible for the other information contained within the Annual Report. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon. Our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in course of the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether this gives rise to a material misstatement in the financial statements themselves. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact. We summarise below our work in relation to areas of the other information including those areas upon which we are specifically required to report: Matters we are specifically required to report Our responsibility Our reporting Principal risks and viability statement Review the confirmation and description in the light of the knowledge gathered during the audit, such as through considering the directors’ processes to support the statements made, challenging key judgements and estimates, consideration of historical forecasting accuracy and evaluating macro-economic assumptions. Consider if the statements are aligned with the relevant provisions of the Code. Directors’ Remuneration report Report whether the part of the Directors’ Remuneration report to be audited is properly prepared and the disclosures specified by the Companies Act have been made. Strategic report and directors’ report Report whether they are consistent with the audited financial statements and are prepared in accordance with applicable legal requirements. Report if we have identified any material misstatements in either report in the light of the knowledge and understanding of the Group and of the Parent company and their environment obtained in the course of the audit. As set out in the “Corporate governance statement” section, we have nothing material to report, add or draw attention to in respect of these matters. As set out in the ‘Opinions on other matters prescribed by the Companies Act 2006’ section, in our opinion, the part of the Directors’ Remuneration report to be audited has been prepared in accordance with the Companies Act 2006. As set out in the “Opinions on other matters prescribed by the Companies Act 2006” section, in our opinion, based on the work undertaken in the course of the audit, the information in these reports is consistent with the audited financial statements and has been prepared in accordance with applicable legal requirements. As referenced on page 70, we have provided limited assurance in accordance with International Standards for Assurance Engagements (ISAE) 3000 and ISAE 3410 over selected metrics on page 70. 176 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued Other reporting on other information Our responsibility Alternative performance measures (APMs) APMs are measures that are not defined by generally accepted accounting practice (GAAP) and therefore are not typically included in the financial statement part of the Annual Report. The Group use APMs, such as adjusted profit, free cash flow and constant currency growth rates in its reporting of financial performance. We have reviewed and assessed the calculation and reporting of these metrics to assess consistency with the Group’s published definitions and policies for these items. We have also considered and assessed whether the use of APMs in the Group’s reporting results is consistent with the guidelines produced by regulators such as the European Securities and Markets Authority (ESMA) guidelines on the use of APMs and the FRC Alternative Performance Measures Thematic Review published in October 2021. We also considered whether there was an appropriate balance between the use of statutory metrics and APMs, in addition to whether clear definitions and reconciliation for APMs used in financial reporting have been provided. Dividends and distribution policy Consider whether the dividends policy is transparent, and the dividends paid are consistent with the policy, as outlined in the strategic report on page 92. Our reporting In our opinion: – The use, calculation and disclosure of APMs is consistent with the Group’s published definitions and policies; – The use of APMs in the Group’s reporting results is consistent with the guidelines produced by ESMA and FRC; and – There is an appropriate balance between the use of statutory metrics and APMs, together with clear definitions and reconciliation for APMs used in financial reporting. In our opinion the dividends policy is appropriately disclosed, and dividends paid are consistent with the policy. 9. Responsibilities of directors As explained more fully in the directors’ responsibilities statement, the directors are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the directors determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error. In preparing the financial statements, the directors are responsible for assessing the Group’s and the Parent company’s ability to continue as a going concern, disclosing as applicable, matters related to going concern and using the going concern basis of accounting unless the directors either intend to liquidate the Group or the Parent company or to cease operations, or have no realistic alternative but to do so. 10. Auditor’s responsibilities for the audit of the financial statements Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements. A further description of our responsibilities for the audit of the financial statements is located on the FRC’s website at: www.frc.org.uk/auditorsresponsibilities. This description forms part of our auditor’s report. 177 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued 11. Extent to which the audit was considered capable of detecting irregularities, including fraud Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud is detailed below. Identifying and assessing potential risks related to irregularities In identifying and assessing the risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, we considered the following: – the nature of the industry and sector, control environment and business performance including the design of the Group’s remuneration policies, key drivers for directors’ remuneration, bonus levels and performance targets; – results of our enquiries of the senior leadership team, internal audit and the Audit & Risk Committee, including obtaining and reviewing supporting documentation, concerning the Group’s policies and procedures relating to: – identifying, evaluating and complying with laws and regulations and whether they were aware of any instances of non-compliance; – detecting and responding to the risks of fraud and whether they have knowledge of any actual, suspected or alleged fraud; and – the internal controls established to mitigate risks related to fraud or non-compliance with laws and regulations. – the matters discussed among the engagement team including significant component audit teams and involving relevant internal specialists, including tax, valuations, pensions, IT and industry specialists regarding how and where fraud might occur in the financial statements and any potential indicators of fraud. We obtained an understanding of the legal and regulatory frameworks that the Group operates in, focusing on provisions of those laws and regulations that had a direct effect on the determination of material amounts and disclosures in the financial statements. The key laws and regulations we considered in this context included the provisions of the UK Companies Act, pensions legislation and tax legislation. We have also considered key laws and regulations that had a fundamental effect on the operations of the Group, including the Good Clinical Practice, the FDA regulations, General Data Protection requirements, Anti-bribery and corruption policy and the Foreign Corrupt Practices Act. Audit response to risks identified As a result of performing the above, we identified the Valuation of US Returns and Rebates accruals as a key audit matter related to the potential risk of fraud. The key audit matters section of our report explains the matter in more detail and also describes the specific procedures in response to that key audit matter. In common with all audits under ISAs (UK), we are also required to perform specific procedures to respond to the risk of management override. In addition to the above, our procedures to respond to risks identified included the following: – reviewing the financial statement disclosures and testing to supporting documentation to assess compliance with provisions of relevant laws and regulations described as having a direct effect on the financial statements; – enquiring of the senior leadership team, the Audit & Risk Committee and in-house and external legal counsel concerning actual and potential litigation and claims; – performing analytical procedures to identify any unusual or unexpected relationships that may indicate risks of material misstatement due to fraud; – reading minutes of meetings of those charged with governance, reviewing internal audit reports and correspondence with regulators; and – in addressing the risk of fraud through management override of controls, testing the appropriateness of journal entries and other adjustments; assessing whether the judgements made in making accounting estimates are indicative of a potential bias; and evaluating the business rationale of any significant transactions that are unusual or outside the normal course of business. We also communicated relevant identified laws and regulations and potential fraud risks to all engagement team members and significant component audit teams and remained alert to any indications of fraud or non-compliance with laws and regulations throughout the audit. Report on other legal and regulatory requirements 12. Opinions on other matters prescribed by the Companies Act 2006 In our opinion, the part of the Directors’ Remuneration report to be audited has been properly prepared in accordance with the Companies Act 2006. In our opinion, based on the work undertaken in the course of the audit: – the information given in the strategic report and the directors’ report for the financial year for which the financial statements are prepared is consistent with the financial statements; and – the strategic report and the directors’ report have been prepared in accordance with applicable legal requirements. In the light of the knowledge and understanding of the Group and of the Parent company and their environment obtained in the course of the audit, we have not identified any material misstatements in the strategic report or the directors’ report. 178 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Independent Auditor's report continued Report on the audit of the financial statements continued 13. Corporate governance statement The Listing Rules require us to review the directors’ statement in relation to going concern, longer-term viability and that part of the corporate governance statement relating to the Group’s compliance with the provisions of the UK Corporate Governance Code specified for our review. Based on the work undertaken as part of our audit, we have concluded that each of the following elements of the Corporate Governance Statement is materially consistent with the financial statements and our knowledge obtained during the audit: – the directors’ statement with regards to the appropriateness of adopting the going concern basis of accounting and any material uncertainties identified set out on page 165; – the directors’ explanation as to its assessment of the Group’s prospects, the period this assessment covers and why the period is appropriate is set out on page 76; – the directors’ statement on fair, balanced and understandable Annual Report set out on page 138; – the board’s confirmation that it has carried out a robust assessment of the emerging and principal risks set out on pages 57 to 61; – the section of the Annual Report that describes the review of effectiveness of risk management and internal control systems set out on pages 134 to 135; and – the section describing the work of the Audit and Risk committee set out on page 133 to 138. 14. Matters on which we are required to report by exception Adequacy of explanations received and accounting records Under the Companies Act 2006 we are required to report to you if, in our opinion: – we have not received all the information and explanations we require for our audit; or – adequate accounting records have not been kept by the Parent company, or returns adequate for our audit have not been received from branches not visited by us; or – the Parent company financial statements are not in agreement with the accounting records and returns. We have nothing to report in respect of these matters. Directors’ remuneration Under the Companies Act 2006 we are also required to report if in our opinion certain disclosures of directors’ remuneration have not been made or the part of the directors’ remuneration report to be audited is not in agreement with the accounting records and returns. We have nothing to report in respect of these matters. 15. Other matters which we are required to address Auditor tenure Following the recommendation of the Audit & Risk Committee, with effect from 1 January 2018 we were appointed by the Board of Directors to audit the financial statements for the year ended 31 December 2018 and subsequent financial periods. The period of total uninterrupted engagement of the firm is six years. Consistency of the audit report with the additional report to the Audit & Risk Committee Our audit opinion is consistent with the additional report to the Audit & Risk Committee we are required to provide in accordance with ISAs (UK). 16. Use of our report This report is made solely to the Parent company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the Parent company’s members those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Parent company and the Parent company’s members as a body, for our audit work, for this report, or for the opinions we have formed. As required by the Financial Conduct Authority (FCA) Disclosure Guidance and Transparency Rule (DTR) 4.1.15R-DTR 4.1.18R, these financial statements will form part of the Electronic Format Annual Financial Report filed on the National Storage Mechanism of the FCA in accordance with DTR 4.1.15R-DTR 4.1.18R. This auditor's report provides no assurance over whether the Electronic Format Annual Financial Report has been prepared in compliance with DTR 4.1.15R-DTR 4.1.18R. The Parent company has passed a resolution in accordance with section 506 of the Companies Act 2006 that the senior statutory auditor’s name should not be stated. Deloitte LLP Statutory Auditor London, United Kingdom 27 February 2024 179 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Consolidated income statement for the year ended 31 December 2023 Turnover Cost of sales Gross profit Selling, general and administration Research and development Royalty income Other operating income/(expense) Operating profit Finance income Finance expense Share of after tax profit/(loss) of associates and joint ventures Profit/(loss) on disposal of interests in associates and joint ventures Profit before taxation Taxation Profit after taxation from continuing operations Profit after taxation from discontinued operations and other gains/(losses) from the demerger Re-measurement of discontinued operations distributed to shareholders on demerger Profit after taxation from discontinued operations Total profit after taxation for the year Profit attributable to non-controlling interests from continuing operations Profit attributable to shareholders from continuing operations Profit attributable to non-controlling interests from discontinued operations Profit attributable to shareholders from discontinued operations Total profit attributable to non-controlling interests Total profit attributable to shareholders Basic earnings per share (pence) from continuing operations Basic earnings per share (pence) from discontinued operations Total basic earnings per share (pence) Diluted earnings per share (pence) from continued operations Diluted earnings per share (pence) from discontinued operations Total diluted earnings per share (pence) Notes 6 7 8 11 12 13 13 14 15 15 2023 £m 30,328 (8,565) 21,763 (9,385) (6,223) 953 (363) 6,745 115 (792) (5) 1 6,064 (756) 5,308 – – – 5,308 380 4,928 – – 5,308 380 4,928 5,308 121.6p – 121.6p 119.9p – 119.9p 2022 £m 29,324 (9,554) 19,770 (8,372) (5,488) 758 (235) 6,433 76 (879) (2) – 5,628 (707) 4,921 3,049 7,651 10,700 15,621 460 4,461 205 10,495 15,621 665 14,956 15,621 110.8p 260.6p 371.4p 109.2p 257.0p 366.2p 2021 £m 24,696 (8,163) 16,533 (7,070) (5,019) 417 (504) 4,357 14 (769) 33 (36) 3,599 (83) 3,516 1,580 – 1,580 5,096 200 3,316 511 1,069 5,096 711 4,385 5,096 82.9p 26.7p 109.6p 81.8p 26.4p 108.2p Consolidated statement of comprehensive income for the year ended 31 December 2023 Total profit for the year Other comprehensive income/(expense) for the year Items that may be reclassified subsequently to continuing operations income statement: Exchange movements on overseas net assets and net investment hedges Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries associates Fair value movements on cash flow hedges Deferred tax on fair value movements on cash flow hedges Reclassification of cash flow hedges to income statement Items that will not be reclassified to continuing operations income statement: Exchange movements on overseas net assets of non-controlling interests Fair value movements on equity investments Tax on fair value movements on equity investments Fair value movements on cash flow hedges Remeasurement gains/(losses) on defined benefit plans Tax on remeasurement losses/(gains) on defined benefit plans Other comprehensive income /(expense) for the year from continuing operations Other comprehensive income for the year from discontinued operations Total comprehensive income for the year Total comprehensive income for the year attributable to: Shareholders Non-controlling interests Total comprehensive income for the year Notes 2023 £m 5,308 2022 £m 15,621 2021 £m 5,096 38 38 38 38 (22) 113 (339) (34) (1) 1 4 (52) (25) (244) 14 (40) 71 (41) (265) (317) – 4,991 4,636 355 4,991 2 (18) 9 14 120 (28) (754) 56 (6) (786) 211 (1,307) (1,187) 356 14,790 14,153 637 14,790 (25) 5 (8) 12 (355) (20) (911) 131 – 940 (223) (83) (438) 101 4,759 4,068 691 4,759 180 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Consolidated balance sheet as at 31 December 2023 Non-current assets Property, plant and equipment Right of use assets Goodwill Other intangible assets Investments in associates and joint ventures Other investments Deferred tax assets Other non-current assets Total non-current assets Current assets Inventories Current tax recoverable Trade and other receivables Derivative financial instruments Current equity investments Liquid investments Cash and cash equivalents Assets held for sale Total current assets Total assets Current liabilities Short-term borrowings Contingent consideration liabilities Trade and other payables Derivative financial instruments Current tax payable Short-term provisions Total current liabilities Non-current liabilities Long-term borrowings Corporation tax payable Deferred tax liabilities Pensions and other post-employment benefits Other provisions Contingent consideration liabilities Other non-current liabilities Total non-current liabilities Total liabilities Net assets Equity Share capital Share premium account Retained earnings Other reserves Shareholders’ equity Non-controlling interests Total equity Notes 2023 £m 2022 £m 17 18 19 20 21 23 14 24 25 14 26 44 22 30 27 28 30 33 29 44 14 32 30 14 14 31 32 33 34 37 37 38 38 9,020 937 6,811 14,768 55 1,137 6,049 1,584 40,361 5,498 373 7,385 130 2,204 42 2,936 76 8,933 687 7,046 14,318 74 1,467 5,658 1,194 39,377 5,146 405 7,053 190 4,087 67 3,723 98 18,644 59,005 20,769 60,146 (2,813) (1,053) (3,952) (1,289) (15,844) (16,263) (114) (500) (744) (183) (471) (652) (21,068) (22,810) (15,205) (17,035) (75) (311) (2,340) (495) (5,609) (1,107) (127) (289) (2,579) (532) (5,779) (899) (25,142) (27,240) (46,210) (50,050) 12,795 10,096 1,348 3,451 7,239 1,309 13,347 (552) 12,795 1,347 3,440 4,363 1,448 10,598 (502) 10,096 The financial statements on pages 180 to 266 were approved by the Board on 27 February, 2024 and signed on its behalf by Sir Jonathan Symonds Chair 181 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Consolidated statement of changes in equity for the year ended 31 December 2023 Shareholders’ equity Share capital £m 1,346 Share premium £m 3,281 Non-controlling interests £m 6,221 At 31 December 2020 Profit for the year Other comprehensive income/(expense) for the year Total comprehensive income/(expense) for the year Distributions to non-controlling interests Contributions from non-controlling interests Dividends to shareholders Shares issued Realised after tax profits on disposal of equity investments Share of associates and joint ventures realised profits on disposal of equity investments Write-down of shares held by ESOP Trusts Share-based incentive plans Transaction with non-controlling interests Tax on share-based incentive plans At 31 December 2021 Profit for the year Other comprehensive income/(expense) for the year Total comprehensive income/(expense) for the year Distributions to non-controlling interests Non-cash distribution to non-controlling interests Contributions from non-controlling interests Changes to non-controlling interests Deconsolidation of former subsidiaries Dividends to shareholders Non-cash dividend to shareholders Realised after tax losses on disposal or liquidation of equity investments Share of associates and joint ventures realised profits on disposal of equity investments Shares issued Write-down of shares held by ESOP Trusts Shares acquired by ESOP Trusts Share-based incentive plans Tax on share-based incentive plans Hedging gain after taxation transferred to non-financial assets At 31 December 2022 Profit for the year Other comprehensive income/(expense) for the year Total comprehensive income/(expense) for the year Distributions to non-controlling interests Contributions from non-controlling interests Dividends to shareholders Realised after tax losses on disposal or liquidation of equity investments Share of associates and joint ventures realised profits on disposal of equity investments Shares issued Write-down of shares held by ESOP Trusts Shares acquired by ESOP Trusts Share-based incentive plans Hedging gain/(loss) after taxation transferred to non-financial assets Tax on share-based incentive plans At 31 December 2023 Retained earnings £m 6,755 4,385 454 4,839 – – (3,999) Other reserves* £m 3,205 – (771) (771) – – – – 132 (132) 20 – – – – – – – – – – – – – – – – – – – 1 – – – – – – Total £m 14,587 4,385 (317) 4,068 – – (3,999) 21 – – – 367 – 11 (7) 168 – – – 2,463 – 15,055 14,956 (714) (714) (803) 14,153 – – – – – – – (14) (7) – 911 (1,200) – – 9 1,448 – (247) (247) – – – – – – – – (3,467) (15,526) – – 25 – – 357 (8) 9 10,598 4,928 (292) 4,636 – – (2,247) 7 (168) 367 – 11 7,944 14,956 (89) 14,867 – – – – – (3,467) (15,526) 14 7 – (911) 1,086 357 (8) – 4,363 4,928 (45) 4,883 – – (2,247) (26) 26 (7) – 7 – (324) 324 283 307 – 7 (285) – 36 – – – 10 – – 307 36 7 1,347 3,301 – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – 25 – 114 – – – 1,347 3,440 – – – – – – – – 1 – – – – – – – – – – – – – 9 – 2 – – – Total equity £m 20,808 5,096 (337) 4,759 (642) 7 (3,999) 21 – – – 367 10 11 711 (20) 691 (642) 7 – – – – – – 10 – 6,287 665 (28) 637 21,342 15,621 (831) 14,790 (1,409) (1,409) (2,960) (2,960) 8 (20) 8 (20) (3,045) (3,045) – – – – – – – – – – (3,467) (15,526) – – 25 – – 357 (8) 9 (502) 10,096 380 (25) 355 (412) 7 – – – – – – – – – 5,308 (317) 4,991 (412) 7 (2,247) – – 10 – – 307 36 7 1,348 3,451 7,239 1,309 13,347 (552) 12,795 * an analysis of Other reserves is presented as part of Note 38, ‘Movements in equity’. 182 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Consolidated cash flow statement for the year ended 31 December 2023 Cash flow from operating activities Profit after taxation from continuing operations for the year Adjustments reconciling profit after tax to operating cash flows Cash generated from operations attributable to continuing operations Taxation paid Net cash inflow/(outflow) from continuing operating activities Cash generated from operations attributable to discontinued operations Taxation paid from discontinued operations Net operating cash flows attributable to discontinued operations Total net cash inflow/(outflow) from operating activities Cash flow from investing activities Purchase of property, plant and equipment Proceeds from sale of property, plant and equipment Purchase of intangible assets Proceeds from sale of intangible assets Purchase of equity investments (Increase)/decrease in liquid investments Purchase of businesses, net of cash acquired Proceeds from sale of equity investments Contingent consideration paid Disposal of businesses Investments in associates and joint ventures Proceeds from disposal of associates and joint ventures Interest received Dividend and distributions from investments Dividends from associates and joint ventures Net cash inflow/(outflow) from continuing investing activities Net investing cash flows attributable to discontinued operations Total net cash inflow/(outflow) from investing activities Cash flow from financing activities Issue of share capital Repayment of long-term loans Issue of long-term notes Repayment of short-term loans Net increase in/(repayment of) other short-term loans Repayment of lease liabilities Interest paid Dividends paid to shareholders Distributions to non-controlling interests Contributions from non-controlling interests Other financing items Net cash inflow/(outflow) from continuing financing activities Net financing cash flows attributable to discontinued operations Total net cash inflow/(outflow) from financing activities Increase/(decrease) in cash and bank overdrafts Cash and bank overdrafts at the beginning of year Exchange adjustments Increase/(decrease) in cash and bank overdrafts in the year Cash and bank overdrafts at the end of year Cash and bank overdrafts at end of year comprise: Cash and cash equivalents Overdrafts Notes 42 41 41 2023 £m 5,308 2,788 8,096 2022 £m 4,921 3,023 7,944 (1,328) (1,310) 6,768 – – – 6,768 6,634 932 (163) 769 7,403 2021 £m 3,516 3,733 7,249 (972) 6,277 1,994 (319) 1,675 7,952 (1,314) (1,143) 28 146 (950) 132 (1,030) (1,115) (1,704) 12 (123) 72 (1,457) 1,832 (11) 49 – 1 115 220 11 196 (143) 1 (3,108) 238 (79) (43) (1) – 64 – 6 641 (162) 18 – 202 (114) (17) (1) 277 14 – 9 (1,595) – (1,595) (4,981) (3,791) (8,772) (1,655) (122) (1,777) 37 10 25 (144) (1,594) 223 1,025 21 – – (2,116) (5,074) (2,304) (333) (197) (766) 1,021 (202) (848) 301 (181) (772) (2,247) (3,467) (3,999) (412) (521) (239) 43 7 334 8 376 (5,641) (9,251) – (5,641) (468) 3,425 (99) (468) 2,858 2,936 (78) 2,858 10,074 823 (546) 3,819 152 (546) 3,425 3,723 (298) 3,425 7 40 (7,126) (463) (7,589) (1,414) 5,262 (29) (1,414) 3,819 4,274 (455) 3,819 183 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements 1. Presentation of the financial statements In preparing the consolidated financial statements, the Group has considered the impact of both physical and transitional climate change risks, as well as the plans to mitigate against these, on the current valuation of assets and liabilities; particularly in the context of the risks identified in the Task Force on Climate-related Financial Disclosures (“TCFD”). The Group does not believe that there is a material impact to judgements and estimates in relation to climate-related risks and, as a result, the valuation of the assets or liabilities have not been significantly impacted as at 31 December 2023. The Group has reviewed the recoverable values of property, plant and equipment, inventories, goodwill and intangible assets as those are the material balances impacted by climate-related risks, and the Group’s transition plans to mitigate those risks. One of the climate-related risks identified relates to metered- dose inhalers (MDI). The Group is addressing this risk by transitioning to a lower-carbon propellant. The transition is not expected to have a material impact on the recoverable amount, or estimated useful lives, of related property, plant and equipment. See Note 17 'Property, plant and equipment' for further details. Whilst there is currently no significant medium-term impact expected, the Group is aware of the ever-changing risks attached to climate change and continues to assess the impact on judgements and estimates, and on the preparation of the consolidated financial statements. Parent company financial statements The financial statements of the parent company, GSK plc, have been prepared in accordance with UK GAAP and with UK accounting presentation. The company balance sheet is presented on page 267 and the accounting policies are given on pages 268 to 271. Description of business GSK is a global biopharma group which prevents and treats disease with vaccines, specialty and general medicines. GSK focuses on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas: infectious diseases, HIV, respiratory/ immunology and oncology. Compliance with applicable law and IFRS The financial statements have been prepared in accordance with UK-adopted international accounting standards in conformity with the requirements of the Companies Act 2006 and the International Financial Reporting Standards as issued by the IASB. Composition of financial statements The consolidated financial statements are drawn up in Sterling, the functional currency of GSK plc, and in accordance with IFRS accounting presentation. The financial statements comprise: – Consolidated income statement – Consolidated statement of comprehensive income – Consolidated balance sheet – Consolidated statement of changes in equity – Consolidated cash flow statement – Notes to the financial statements. Composition of the Group A list of the subsidiaries and associates which, in the opinion of the Directors, principally affected the amount of profit or net assets of the Group is given in Note 46, ‘Principal Group companies’. Financial period These financial statements cover the financial year from 1 January to 31 December 2023, with comparative figures for the financial years from 1 January to 31 December 2022 and, where appropriate, from 1 January to 31 December 2021. Accounting principles and policies The financial statements have been prepared using the historical cost convention modified by the revaluation of certain items, as stated in the accounting policies, and on a going concern basis. The financial statements have been prepared in accordance with the Group’s accounting policies approved by the Board and described in Note 2, ‘Accounting principles and policies’. Information on the application of these accounting policies, including areas of estimation and judgement is given in Note 3, ‘Critical accounting judgements and key sources of estimation uncertainty’. The preparation of the financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. 184 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 2. Accounting principles and policies Consolidation The consolidated financial statements include: – the assets and liabilities, and the results and cash flows, of the company and its subsidiaries, including ESOP Trusts – the Group’s share of the results and net assets of associates and joint ventures – the Group’s share of assets, liabilities, revenue and expenses of joint operations. The financial statements of entities consolidated are made up to 31 December each year. Entities over which the Group has the power to direct the relevant activities so as to affect the returns to the Group, generally through control over the financial and operating policies, are accounted for as subsidiaries. Where the Group has the ability to exercise joint control over, and rights to, the net assets of entities, the entities are accounted for as joint ventures. Where the Group has the ability to exercise joint control over an arrangement, but has rights to specified assets and obligations for specified liabilities of the arrangement, the arrangement is accounted for as a joint operation. Where the Group has the ability to exercise significant influence over entities, they are accounted for as associates. The results and assets and liabilities of associates and joint ventures are incorporated into the consolidated financial statements using the equity method of accounting. The assets, liabilities, revenue and expenses of joint operations are included in the consolidated financial statements in accordance with the Group’s rights and obligations. Interests acquired in entities are consolidated from the date the Group acquires control and interests sold are de-consolidated from the date control ceases. Transactions and balances between subsidiaries are eliminated and no profit before tax is taken on sales between subsidiaries until the products are sold to customers outside the Group. The relevant proportion of profits on transactions with joint ventures, joint operations and associates is also deferred until the products are sold to third parties. Transactions with non- controlling interests are recorded directly in equity. Deferred tax relief on unrealised intra-Group profit is accounted for only to the extent that it is considered recoverable. Business combinations Business combinations are accounted for using the acquisition accounting method. Identifiable assets, liabilities and contingent liabilities acquired are measured at fair value at acquisition date. The consideration transferred is measured at fair value and includes the fair value of any contingent consideration. The fair value of contingent consideration liabilities is reassessed at each balance sheet date with changes recognised in the income statement. Payments of contingent consideration reduce the balance sheet liability and as a result are not recorded in the income statement. The part of each payment relating to the original estimate of the fair value of the contingent consideration on acquisition is reported within investing activities in the cash flow statement and the part of each payment relating to the increase in the liability since the acquisition date is reported within operating cash flows. Where the consideration transferred, together with the non- controlling interest, exceeds the fair value of the net assets, liabilities and contingent liabilities acquired, the excess is recorded as goodwill. The costs of effecting an acquisition are charged to the income statement in the period in which they are incurred. Goodwill is capitalised as a separate item in the case of subsidiaries and as part of the cost of investment in the case of joint ventures and associates. Goodwill is denominated in the currency of the operation acquired. Where the cost of acquisition is below the Group’s interest in the net assets acquired, the difference is recognised directly in the income statement. Where not all of the equity of a subsidiary is acquired the non- controlling interest is recognised either at fair value or at the non-controlling interest’s share of the net assets of the subsidiary, on a case-by-case basis. Changes in the Group’s ownership percentage of subsidiaries are accounted for within equity. Foreign currency translation Foreign currency transactions are booked in the functional currency of the Group company at the exchange rate ruling on the date of transaction. Foreign currency monetary assets and liabilities are retranslated into the functional currency at rates of exchange ruling at the balance sheet date. Exchange differences are included in the income statement. On consolidation, assets and liabilities, including related goodwill, of overseas subsidiaries, associates and joint ventures, are translated into Sterling at rates of exchange ruling at the balance sheet date. The results and cash flows of overseas subsidiaries, associates and joint ventures are translated into sterling using average rates of exchange. Exchange adjustments arising when the opening net assets and the profits for the year retained by overseas subsidiaries, associates and joint ventures are translated into Sterling, less exchange differences arising on related foreign currency borrowings which hedge the Group’s net investment in these operations, are taken to a separate component of equity within Retained Earnings. When translating into Sterling the assets, liabilities, results and cash flows of overseas subsidiaries, associates and joint ventures which are reported in currencies of hyper-inflationary economies, adjustments are made where material to reflect current price levels. Any loss on net monetary assets is charged to the consolidated income statement. 185 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 2. Accounting principles and policies continued Revenue Turnover The Group receives revenue for supply of goods to external customers against orders received. The majority of contracts that GSK enters into relate to sales orders containing single performance obligations for the delivery of pharmaceutical and vaccine products. The average duration of a sales order is less than 12 months. Product revenue is recognised when control of the goods is passed to the customer. The point at which control passes is determined by each customer arrangement, but generally occurs on delivery to the customer. Product revenue represents net invoice value including fixed and variable consideration. Variable consideration arises on the sale of goods as a result of discounts and allowances given and accruals for estimated future returns and rebates. Revenue is not recognised in full until it is highly probable that a significant reversal in the amount of cumulative revenue recognised will not occur. The methodology and assumptions used to estimate rebates and returns are monitored and adjusted regularly in the light of contractual and legal obligations, historical trends, past experience and projected market conditions. Estimates associated with returns and rebates are revisited at each reporting date or when they are resolved and revenue is adjusted accordingly. Please refer to Note 3, 'Critical accounting judgements and key sources of estimation uncertainty' for the details on rebates, discounts and allowances. The Group has entered into collaborative agreements, typically with other pharmaceutical or biotechnology companies to develop, produce and market drug candidates and vaccines that do not qualify as joint arrangements. When GSK has control over the commercialisation activities, the Group recognises turnover and cost of sales on a gross basis. Profit sharing amounts and royalties due to the counterparty are recorded within cost of sales. Cost of sales includes net recoveries of cost of £45 million (2022: cost of £1,635 million; 2021: cost of £640 million) from profit sharing arrangements and royalties due to the counterparty. When the counterparty controls the commercialisation activities and records the sale, the Group is not the principal in the customer contract and instead records its share of gross profit as co-promotion income, on a net basis, within turnover. The nature of co- promotion activities is such that the Group records no costs of sales. Commercial Operations turnover includes co-promotion revenue of £1 million (2022: £3 million; 2021: £7 million). Reimbursements to and from the counterparty under collaboration agreements for ‘selling, general and administration’ and ‘research and development’ costs are recorded net in the respective lines in the consolidated income statement. Other operating income and royalty income GSK enters into development and marketing collaborations and out-licences of the Group’s compounds or products to other parties. These contracts give rise to fixed and variable consideration from upfront payments, development milestones, sales-based milestones and royalties. Income dependent on the achievement of a development milestone is recognised when it is highly probable that a significant reversal in the amount of cumulative revenue recognised will not occur, which is usually when the related event occurs. Sales-based milestone income is recognised when it is highly probable that the sales threshold will be reached. Sales-based royalties on a licence of intellectual property are not recognised until the relevant product sale occurs. For all revenue, if the time between the recognition of revenue and payment from the customer is expected to be more than one year and the impact is material, the amount of consideration is discounted using appropriate discount rates. Value added tax and other sales taxes are excluded from revenue. Expenditure Expenditure is recognised in respect of goods and services received when supplied in accordance with contractual terms. Provision is made when an obligation exists for a future liability in respect of a past event and where the amount of the obligation can be reliably estimated. Manufacturing start-up costs between validation and the achievement of normal production are expensed as incurred. Advertising and promotion expenditure is charged to the income statement as incurred. Shipment costs on inter-company transfers are charged to cost of sales; distribution costs on sales to customers are included in selling, general and administration expenditure. Restructuring costs are recognised and provided for, where appropriate, in respect of the direct expenditure of a business reorganisation where the plans are sufficiently detailed and well advanced, and where appropriate communication to those affected has been undertaken. Software as a service (SaaS) configuration costs are expensed as they are incurred where the software being configured is controlled by the SaaS provider. Research and development Research and development expenditure is charged to the income statement in the period in which it is incurred. Development expenditure is capitalised when the criteria for recognising an asset are met, usually when a regulatory filing has been made in a major market and approval is considered highly probable. Property, plant and equipment used for research and development is capitalised and depreciated in accordance with the Group’s policy. 186 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 2. Accounting principles and policies continued Legal and other disputes Employee share plans Provision is made for the anticipated settlement costs of legal or other disputes against the Group where an outflow of resources is considered probable and a reliable estimate can be made of the likely outcome. In respect of product liability claims related to certain products, provision is made when there is sufficient history of claims made and settlements to enable management to make a reliable estimate of the provision required to cover asserted and unasserted claims. In certain cases, an incurred but not reported (IBNR) actuarial technique is used to determine this estimate. In addition, provision is made for legal or other expenses arising from claims received or other disputes. The Group may become involved in legal proceedings, in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability. In these cases, appropriate disclosure about such cases is included but no provision is made. Costs associated with claims made by the Group against third parties are charged to the income statement as they are incurred. Pensions and other post-employment benefits The costs of providing pensions under defined benefit schemes are calculated using the projected unit credit method and spread over the period during which benefit is expected to be derived from the employees’ services, consistent with the advice of qualified actuaries. Pension obligations are measured as the present value of estimated future cash flows discounted at rates reflecting the yields of high-quality corporate bonds. Pension scheme assets are measured at fair value at the balance sheet date. The costs of other post-employment liabilities are calculated in a similar way to defined benefit pension schemes and spread over the period during which benefit is expected to be derived from the employees’ services, in accordance with the advice of qualified actuaries. The service cost of providing retirement benefits to employees during the year, together with the cost of any curtailment, is charged to operating profit in the year. Actuarial gains and losses and the effect of changes in actuarial assumptions are recognised in the statement of comprehensive income in the year in which they arise. The Group’s contributions to defined contribution plans are charged to the income statement as incurred. Incentives in the form of shares are provided to employees under share option and share award schemes. The fair values of these options and awards are calculated at their grant dates using a Black-Scholes option pricing model and charged to the income statement over the relevant vesting periods. The Group provides finance to ESOP Trusts to purchase company shares to meet the obligation to provide shares when employees exercise their options or awards. Costs of running the ESOP Trusts are charged to the income statement. Shares held by the ESOP Trusts are deducted from other reserves. A transfer is made between other reserves and retained earnings over the vesting periods of the related share options or awards to reflect the ultimate proceeds receivable from employees on exercise. Property, plant and equipment Property, plant and equipment (PP&E) is stated at the cost of purchase or construction, less provisions for depreciation and impairment. Financing costs are capitalised within the cost of qualifying assets in construction. Depreciation is calculated to write off the cost less residual value of PP&E, excluding freehold land, using the straight-line basis over the expected useful life. Residual values and lives are reviewed, and where appropriate adjusted annually. The normal expected useful lives of the major categories of PP&E are: Freehold buildings 20 to 50 years Leasehold land and buildings Lease term or 20 to 50 years Plant and machinery Equipment and vehicles 10 to 20 years 3 to 10 years On disposal of PP&E, the cost and related accumulated depreciation and impairments are removed from the financial statements and the net amount, less any proceeds, is taken to the income statement. Leases The Group recognises right of use assets under lease arrangements in which it is the lessee, except for short-term leases (defined as leases with a lease term of 12 months or less) and leases of low value assets. Rights to use assets owned by third parties under lease agreements are capitalised at the inception of the lease and recognised on the consolidated balance sheet. The corresponding liability to the lessor is recognised as a lease obligation within short and long-term borrowings. The carrying amount is subsequently increased to reflect interest on the lease liability and reduced by lease payments made. For calculating the discounted lease liability on leases with annual payments of £2 million or more, the implicit rate in the lease is used. If this is not available, the incremental borrowing rate with a lease specific adjustment is used. If neither of these is available, and for leases with annual payments of less than £2 million, the incremental borrowing rate is used. The incremental borrowing rate is the rate of interest at which GSK would have been able to borrow for a similar term and with a similar security the funds necessary to obtain a similar asset in a similar market. 187 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 2. Accounting principles and policies continued Finance costs are charged to the income statement so as to produce a constant periodic rate of charge on the remaining balance of the obligations for each accounting period. Variable rents are not part of the lease liability and the right of use asset. These payments are charged to the income statement as incurred. Lease rental costs for short-term and low-value leases which are not capitalised are also charged to the income statement as incurred. Non-lease components are accounted for separately from the lease components in plant and equipment leases but are not separately accounted for in land and buildings or vehicle leases. If modifications or reassessments of lease obligations occur, the lease liability and right of use asset are remeasured. Right of use assets where title is expected to pass to GSK at a point in the future are depreciated on a basis consistent with similar owned assets. In other cases, right of use assets are depreciated over the shorter of the useful life of the asset or the lease term. Goodwill Goodwill is stated at cost less impairments. Goodwill is deemed to have an indefinite useful life and is tested for impairment at least annually. Where the fair value of the interest acquired in an entity’s assets, liabilities and contingent liabilities exceeds the consideration paid, this excess is recognised immediately as a gain in the income statement. Other intangible assets Intangible assets are stated at cost less provisions for amortisation and impairments. Licences, patents, know-how and marketing rights separately acquired or acquired as part of a business combination are amortised over their estimated useful lives, generally not exceeding 30 years, using the straight-line basis, from the time they are available for use. The estimated useful lives for determining the amortisation charge take into account patent lives (exclusivity period), where applicable, as well as the value obtained from periods of non-exclusivity. For Pharmaceutical intangible assets, depending on the characteristics, competitive environment and estimated long-term profits of the asset, between 80% to 90% of the book value is amortised over the exclusivity period on a straight-line basis and the remaining book value is amortised over a non-exclusivity period of 5-15 years on a straight-line basis. For Vaccines intangible assets, cost is usually amortised over the exclusivity period plus 10 years, or 30 years if no exclusivity period is granted, on a straight-line basis. Asset lives are reviewed, and where appropriate adjusted, annually. Contingent milestone payments are recognised at the point that the contingent event becomes probable. Any development costs incurred by the Group and associated with acquired licences, patents, know-how or marketing rights are written off to the income statement when incurred, unless the criteria for recognition of an internally generated intangible asset are met, usually when a regulatory filing has been made in a major market and approval is considered highly probable. Acquired in process R&D and marketed products are valued independently as part of the fair value of businesses acquired from third parties where they have a value which is substantial and long term and where the assets either are contractual or legal in nature or can be sold separately from the rest of the businesses acquired. The costs of acquiring and developing computer software for internal use and internet sites for external use are capitalised as intangible fixed assets where the software or site supports a significant business system and the expenditure leads to the creation of a durable asset controlled by the Group. ERP systems software is amortised over seven to ten years and other computer software over three to five years using the straight- line basis. Impairment of non-current assets The carrying values of all non-current assets are reviewed for impairment, either on a stand-alone basis or as part of a larger cash generating unit, when there is an indication that the assets might be impaired. Additionally, goodwill and intangible assets which are not yet available for use are tested for impairment annually. Any provision for impairment is charged to the income statement in the year concerned. Impairments of goodwill are not reversed. Impairment losses on other non-current assets are only reversed if there has been a change in estimates used to determine recoverable amounts and only to the extent that the revised recoverable amounts do not exceed the carrying values that would have existed, net of depreciation or amortisation, had no impairments been recognised. Investments in associates, joint ventures and joint operations Investments in associates and joint ventures are carried in the consolidated balance sheet at the Group’s share of their net assets at date of acquisition and of their post-acquisition retained profits or losses and other comprehensive income together with any goodwill arising on the acquisition. The Group recognises the assets, liabilities, revenue and expenses of joint operations in accordance with its rights and obligations. Inventories Inventories are included in the financial statements at the lower of cost (including raw materials, direct labour, other direct costs and related production overheads) and net realisable value. Cost is generally determined on a first in, first out basis. Pre- launch inventory is held as an asset when there is a high probability of regulatory approval for the product. Before that point a provision is made against the carrying value to reduce it to its recoverable amount; the provision is then reversed at the point when a high probability of regulatory approval is determined. 188 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 2. Accounting principles and policies continued Financial instruments Financial assets Financial assets are measured at amortised cost, fair value through other comprehensive income (FVTOCI) or fair value through profit or loss (FVTPL). The measurement basis is determined by reference to both the business model for managing the financial asset and the contractual cash flow characteristics of the financial asset. For financial assets other than trade receivables a 12-month expected credit loss (ECL) allowance is recorded on initial recognition. If there is subsequent evidence of a significant increase in the credit risk of an asset, the allowance is increased to reflect the full lifetime ECL. If there is no realistic prospect of recovery, the asset is written off. Expected credit losses are recognised in the income statement on financial assets measured at amortised cost and at fair value through other comprehensive income apart from equity investments. Current equity investments Current equity investments comprise equity investments which the Group holds with the intention to sell and which it may sell in the short term. Where acquired with this intention, they are measured at FVTPL. They are initially recorded at fair value and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in the income statement. Dividend income is recognised in the income statement when the Group’s right to receive payment is established. Purchases and sales of current equity investments are accounted for on the trade date. Other investments Other investments comprise equity investments and investments in limited life funds. The Group has elected to designate the majority of its equity investments as measured at FVTOCI. They are initially recorded at fair value plus transaction costs and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in other comprehensive income. On disposal of the equity investment, gains and losses that have been deferred in other comprehensive income are transferred directly to retained earnings. Investments in limited life funds are measured at FVTPL. They are initially recorded at fair value and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in the income statement. Dividends on equity investments and distributions from funds are recognised in the income statement when the Group’s right to receive payment is established. Purchases and sales of Other investments are accounted for on the trade date. Trade receivables Trade receivables are measured in accordance with the business model under which each portfolio of trade receivables is held. The Group has portfolios in each of the three business models under IFRS 9: to collect the contractual cash flows where there is no factoring agreement in place (measured at amortised cost); to sell the contractual cash flows where the trade receivables will be sold under a factoring agreement (measured at FVTPL); and both to collect and to sell the contractual cash flows where the trade receivables may be sold under a factoring arrangement (measured at FVTOCI). Trade receivables measured at amortised cost are carried at the original invoice amount less allowances for expected credit losses. Expected credit losses are calculated in accordance with the simplified approach permitted by IFRS 9, using a provision matrix applying lifetime historical credit loss experience to the trade receivables. The expected credit loss rate varies depending on whether, and the extent to which, settlement of the trade receivables is overdue and it is also adjusted as appropriate to reflect current economic conditions and estimates of future conditions. For the purpose of determining credit loss rates, customers are classified into groupings that have similar loss patterns. The key drivers of the loss rate are the nature of the business unit and the location and type of customer. When a trade receivable is determined to have no reasonable expectation of recovery it is written off, firstly against any expected credit loss allowance available and then to the income statement. Subsequent recoveries of amounts previously provided for or written off are credited to the income statement. Long-term receivables are discounted where the effect is material. Cash and cash equivalents Cash held in deposit accounts is measured at amortised cost. Investments in money market funds are held at fair value through profit or loss because the funds fail the solely payments of principal and interest (SPPI) test. Borrowings All borrowings are initially recorded at the amount of proceeds received, net of transaction costs. Borrowings are subsequently carried at amortised cost, with the difference between the proceeds, net of transaction costs, and the amount due on redemption being recognised as a charge to the income statement over the period of the relevant borrowing. Derivative financial instruments Derivative financial instruments are used to manage exposure to market risks. The principal derivative instruments used by GSK are foreign currency swaps, interest rate swaps, foreign exchange forward contracts and options. The Group does not hold or issue derivative financial instruments for trading or speculative purposes. Derivative financial assets and liabilities, including derivatives embedded in host contracts which have been separated from the host contract, are measured at fair value. Changes in the fair value of any derivative instruments that do not qualify for hedge accounting are recognised immediately in the income statement. 189 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 2. Accounting principles and policies continued Hedge accounting Derivatives designated as the hedging instruments are classified at inception of hedge relationship as cash flow hedges, net investment hedges or fair value hedges. Changes in the fair value of derivatives designated as cash flow hedges are recognised in other comprehensive income to the extent that the hedges are effective and accumulated in the cash flow hedge reserve. Ineffective portions are recognised in profit or loss immediately. Amounts deferred in the cash flow hedge reserve are reclassified to the income statement when the hedged item affects profit or loss, or if the hedged forecast transaction is to purchase a non-financial asset, the amount deferred in the cash flow hedge reserve is transferred directly from equity and included in the carrying value of the recognised non-financial asset. Net investment hedges are accounted for in a similar way to cash flow hedges which are reclassified to the income statement when the hedged item affects profit or loss. Changes in the fair value of derivatives designated as fair value hedges are recorded in the income statement, together with the changes in the fair value of the hedged asset or liability. Taxation Current tax is provided at the amounts expected to be paid, applying tax rates that have been enacted or substantively enacted by the balance sheet date. The tax charge for the period is recognised in the income statement, the statement of comprehensive income or directly in equity, according to the accounting treatment of the related transaction. Deferred tax is provided in full on temporary differences arising between the tax bases of assets and liabilities and their carrying amounts in the financial statements. Deferred tax assets are recognised to the extent that it is probable that future taxable profits will be available against which the temporary differences can be utilised. Deferred tax is provided on temporary differences arising on investments in subsidiaries, associates and joint ventures, except where the timing of the reversal of the temporary difference can be controlled and it is probable that the temporary difference will not reverse in the foreseeable future. Deferred tax is provided using rates of tax that have been enacted or substantively enacted by the balance sheet date. Deferred tax assets and liabilities are offset when there is a legally enforceable right to offset current tax assets against current tax liabilities and when they relate to income taxes levied by the same tax authority and the Company and its subsidiaries intend to settle their current tax assets and liabilities on a net basis. Deferred tax assets and liabilities are not recognised if the temporary differences arise from the initial recognition of goodwill or from the initial recognition of other assets and liabilities in a transaction (other than a business combination) that affects neither the accounting nor the taxable profit or loss. Unrecognised deferred tax assets are reassessed at each reporting date and are recognised to the extent that it has become probable that future taxable profits will allow the deferred tax asset to be recovered. Where an uncertain tax position is identified, management will make a judgement as to what the probable outcome will be, assuming the relevant tax authority has full knowledge of the situation. Where it is assessed that an economic outflow is probable to arise, a provision is made for the best estimate of the liability. In estimating any such liability GSK applies a risk- based approach which takes into account, as appropriate, the probability that the Group would be able to obtain compensatory adjustments under international tax treaties. These estimates take into account the specific circumstances of each dispute and relevant external advice. Discounting Where the time value of money is material, balances are discounted to current values using appropriate discount rates. The unwinding of the discounts is recorded in finance income and finance expense. Assets and liabilities held for sale or distribution and discontinued operations Disposal groups are classified as held for sale or distribution if their carrying amount will be recovered principally through sale or a distribution to shareholders rather than through continuing use, they are available for sale or distribution in their present condition and the sale or distribution is considered highly probable. Assets held in Assets held for sale or distribution are measured at the lower of their carrying amount and fair value less costs to sell or distribute. Non-current assets included in Assets held for sale or distribution are not depreciated or amortised. Assets and liabilities classified as held for sale or distribution are presented in current assets and current liabilities separately from the other assets and liabilities in the balance sheet. A discontinued operation is a component of the Group that has been disposed of, distributed or is classified as held for sale or distribution and that represents a separate major line of business. The results of discontinued operations are presented separately in the consolidated income statement, the consolidated statement of other comprehensive income and the consolidated statement of cash flows and comparatives are restated on a consistent basis. 190 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 3. Critical accounting judgements and key sources of estimation uncertainty Revenue is not recognised in full until it is highly probable that a significant reversal in the amount of cumulative revenue recognised will not occur. The amount of turnover recognised in the year from performance obligations satisfied in previous periods is set out in Note 6, ‘Turnover and segment information’, and is an indication of the level of sensitivity in the estimate. Future events could cause the assumptions on which the accruals are based to change, which could materially affect the future results of the Group. Taxation The tax charge for the year was £756 million (2022: £707 million). At 31 December 2023, current tax payable was £500 million (2022: £471 million), non-current corporation tax payable was £75 million (2022: £127 million) and current tax recoverable was £373 million (2022: £405 million). Judgement and estimates The Group has open tax issues with a number of revenue authorities. Management makes a judgement of whether there is sufficient information to be able to make a reliable estimate of the outcome of the dispute. If insufficient information is available, no provision is made. If sufficient information is available, in estimating a potential tax liability GSK applies a risk-based approach which takes into account, as appropriate, the probability that the Group would be able to obtain compensatory adjustments under international tax treaties. These estimates take into account the specific circumstances of each dispute and relevant external advice, are inherently judgemental and could change substantially over time as each dispute progresses and new facts emerge. At 31 December 2023, the Group had recognised provisions of £584 million in respect of uncertain tax positions (2022: £551 million). Due to the number of uncertain tax positions held and the number of jurisdictions to which these relate, it is not practicable to give meaningful sensitivity estimates. No uncertain tax position is individually material to the Group. Factors affecting the tax charge in future years are set out in Note 14, ‘Taxation’. GSK continues to believe that it has made adequate provision for the liabilities likely to arise from open assessments. Where open issues exist, the ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of negotiations with the relevant tax authorities or, if necessary, litigation proceedings. In preparing the financial statements, management is required to make judgements about when or how items should be recognised in the financial statements and estimates and assumptions that affect the amounts of assets, liabilities, revenue and expenses reported in the financial statements. Actual amounts and results could differ from those estimates. The following are considered to be the critical accounting judgements and key sources of estimation uncertainty. Turnover Reported Group turnover for 2023 was £30,328 million (2022: £29,324 million). Estimates Gross turnover is reduced by rebates, discounts, allowances and product returns given or expected to be given, which vary by product arrangements and buying groups. These arrangements with purchasing organisations are dependent upon the submission of claims some time after the initial recognition of the sale. Accruals are made at the time of sale for the estimated rebates, discounts or allowances payable or returns to be made, based on available market information and historical experience. Sales of pharmaceutical and vaccine products in the US have complex arrangements for rebates, discounts and allowances. Turnover of Commercial Operations products in the US for 2023 of £15,820 million (2022: £14,542 million) was after recording deductions of £16,539 million (2022: £15,272 million) for rebates, allowances, returns and other discounts. At 31 December 2023, the total accrual amounted to £5,951 million (2022: £5,855 million). Due to the nature of these accruals it is not practicable to give meaningful sensitivity estimates due to the large volume of variables that contribute to the overall rebates, chargebacks, returns and other revenue accruals. As there can be significant variability in final outcomes, the Group applies a constraint when measuring the variable element within revenue, so that revenue is recognised at a suitably cautious amount. The objective of the constraint is to ensure that it is highly probable that a significant reversal of revenue will not occur when the uncertainties are resolved. The constraint is applied by making suitably cautious estimates of the inputs and assumptions used in estimating the variable consideration. Because the amounts are estimated they may not fully reflect the final outcome, and the amounts are subject to change dependent upon, amongst other things, the types of buying group and product sales mix. The constraints applied in recognising revenue mean that the risk of a material downward adjustment to revenue in the next financial year is low. The level of accrual for rebates and returns is reviewed and adjusted regularly in the light of contractual and legal obligations, historical trends, past experience and projected market conditions. Market conditions are evaluated using wholesaler and other third-party analyses, market research data and internally generated information. It is reasonably possible that there could be a significant adjustment within the next 12 months to recognise additional revenue, if actual outcomes are better than the cautious constrained estimates. 191 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 3. Critical accounting judgements and key sources of estimation uncertainty continued Legal and other disputes Pensions and other post-employment benefits Judgement Where a surplus on a defined benefit scheme arises, or there is potential for a surplus to arise from committed future contributions, the rights of the Trustees to prevent the Group obtaining a refund of that surplus in the future are considered in determining whether it is necessary to restrict the amount of the surplus that is recognised. Three UK schemes are in surplus (2022: two UK schemes), with a combined surplus of £457 million at 31 December 2023 (2022: £109 million). There are further recognised pension surpluses totalling £177 million spread across five countries (2022: £120 million across five countries). GSK has made the judgement that these amounts meet the requirements of recoverability. Estimates The costs of providing pensions and other post-employment benefits are assessed on the basis of assumptions selected by management. These assumptions include future earnings and pension increases, discount rates, expected long-term rates of return on assets and mortality rates, and are disclosed in Note 31, ‘Pensions and other post-employment benefits’. Discount rates are derived from AA rated corporate bond yields except in countries where there is no deep market in corporate bonds where government bond yields are used. A sensitivity analysis is provided in Note 31, ‘Pensions and other post- employment benefits’, a 0.25% reduction in the discount rate would lead to an increase in the net pension deficit of approximately £391 million and an increase in the annual pension cost of approximately £18 million. Similarly, a 0.25% increase in the discount rate would lead to a decrease in the net pension deficit of approximately £373 million and a decrease in the annual pension cost of approximately £18 million. A 0.75% reduction in the discount rate would lead to an increase in the net pension deficit of approximately £1,231 million and an increase in the annual pension cost of approximately £51 million. Similarly, a 0.75% increase in the discount rate would lead to a decrease in the net pension deficit of approximately £1,071 million and a decrease in the annual pension cost of approximately £58 million. The selection of different assumptions could affect the future results of the Group. Legal costs for the year were £271 million (2022: £144 million). At 31 December 2023 provisions for legal and other disputes amounted to £267 million (2022: £218 million). Judgement Management makes a judgement of whether there is sufficient information to be able to make a reliable estimate of the likely outcome of the dispute and the legal and other expenses arising from claims against the Group. If insufficient information is available, no provision is made and disclosure of the claim is given. The estimated provisions take into account the specific circumstances of each dispute and relevant external advice, are inherently judgemental and could change substantially over time as each dispute progresses and new facts emerge. Details of the status and various uncertainties involved in the significant unresolved disputes are set out in Note 47, ‘Legal proceedings’. The company’s Directors, having taken legal advice, have established provisions after taking into account the relevant facts and circumstances of each matter and in accordance with accounting requirements. In respect of product liability claims related to certain products, there is sufficient history of claims made and settlements to enable management to make a reliable estimate of the provision required to cover unasserted claims. The Group may become involved in legal proceedings, in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability. In these cases, appropriate disclosure about such cases would be provided, but no provision would be made and no contingent liability can be quantified. The ultimate liability for legal claims may vary from the amounts provided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations. The position could change over time and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed the amount of the provisions reported in the Group’s financial statements by a material amount. Contingent consideration The 2023 income statement charge for contingent consideration was £768 million (2022: £1,645 million). At 31 December 2023, the liability for contingent consideration amounted to £6,662 million (2022: £7,068 million). Of this amount, £5,718 million (2022: £5,890 million) related to the acquisition of the former Shionogi-ViiV Healthcare joint venture in 2012. Estimates Any contingent consideration included in the consideration payable for a business combination is recorded at fair value at the date of acquisition. These fair values are generally based on risk-adjusted future cash flows discounted using appropriate post-tax discount rates. The fair values are reviewed on a regular basis, and any changes are reflected in the income statement. See Note 33, ‘Contingent consideration liabilities’. 192 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 4. New accounting requirements International Tax Reform - Pillar Two Model Rules - Amendments to IAS 12 The Group has adopted the amendments to IAS 12 which have been introduced in response to the OECD’s BEPS Pillar Two rules and include: Other amendments The adoption of IFRS 17 Insurance Contracts and amendments to certain other IFRS accounting standards in the year ended 31 December 2023, did not have a material impact on the results or financial position of the Group. – A mandatory temporary exception to the recognition and disclosure of deferred taxes arising from the jurisdictional implementation of the Pillar Two model rules; and – Disclosure requirements for affected entities to help users of the financial statements better understand an entity’s exposure to Pillar Two income taxes arising from that legislation. Certain amendments to IFRS accounting standards and interpretations have been published that are not mandatory for 31 December 2023 reporting periods and have not been adopted early by the Group. These amendments and interpretations are not expected to have a material impact on the results or financial position of the Group in future reporting periods. GSK has applied the mandatory exception and is not recognising any deferred tax impact. Further information about the impact of the Pillar Two model framework, including the impact on the effective tax rate for 2024, is set out in Note 14, 'Taxation'. Amendments to IAS 7 Statement of Cash Flows and IFRS 7 Financial Instruments: Disclosures - Supplier Finance Arrangements, require additional disclosure of information about Group supplier finance arrangements. The disclosure requirements will apply for annual reporting periods beginning on or after 1 January 2024, but not for any interim periods ending on or before 31 December 2024. 5. Exchange rates The Group uses the average of exchange rates prevailing during the period to translate the results and cash flows of overseas subsidiaries, joint ventures and associates into sterling and period end rates to translate the net assets of those entities. The currencies which most influence these translations and the relevant exchange rates were: 2023 2022 2021 2023 2022 2021 Average rates: US$/£ Euro/£ Yen/£ Period end rates: 1.24 1.15 175 1.24 1.17 161 1.38 1.16 151 US$/£ Euro/£ Yen/£ 1.27 1.15 180 1.20 1.13 159 1.35 1.19 155 193 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 6. Turnover and segment information Operating segments are reported based on the financial information provided to the Chief Executive Officer and the responsibilities of the GSK Leadership Team (GLT). GSK reports under two segments; Commercial Operations and Total R&D. Members of the GLT are responsible for each segment. Originally GSK reported 2021 results under four segments: Pharmaceuticals, Pharmaceuticals R&D, Vaccines and Consumer Healthcare. However, the reporting of operating segments was changed in 2022 and with the demerger of Consumer Healthcare only two operating segments are reportable. Comparative information was retrospectively revised on a consistent basis in 2022. There is no change to the reportable segments in 2023. R&D investment is essential for the sustainability of the business. However for segment reporting the Commercial Operating profits exclude allocations of globally funded R&D. The Total R&D segment is the responsibility of the Chief Scientific Officer and is reported as a separate segment. The operating costs of this segment includes R&D activities across Specialty Medicines, including HIV and Vaccines. It includes R&D and some Selling, General and Administrative (SG&A) costs relating to regulatory and other functions. The Group’s management reporting process allocates intra-Group profit on a product sale to the segment in which that sale is recorded, and the profit analyses below have been presented on that basis. Turnover by segment Commercial operations 2023 £m 30,328 30,328 2022 £m 29,324 29,324 2021 £m 24,696 24,696 For 2023, product sales are reported within three product groups: Vaccines, Specialty Medicines and General Medicines. Commercial Operations: Shingles Meningitis RSV Influenza Established Vaccines Pandemic Vaccines Vaccines HIV Respiratory/Immunology and Other Oncology Pandemic Specialty Medicines Respiratory Other General Medicines General Medicines Total Commercial Operations 2023 £m 3,446 1,260 1,238 504 3,266 9,714 150 9,864 6,444 3,025 731 10,200 44 10,244 6,825 3,395 10,220 2022 £m 2,958 1,116 – 714 3,085 7,873 64 7,937 5,749 2,609 602 8,960 2,309 11,269 6,548 3,570 10,118 2021 £m 1,721 961 – 679 2,970 6,331 447 6,778 4,777 2,027 489 7,293 958 8,251 6,048 3,619 9,667 30,328 29,324 24,696 194 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 6. Turnover and segment information continued During 2023, sales were made to three US wholesalers of £4,494 million (2022:£4,045 million; 2021: £3,159 million), £4,498 million (2022: £4,161 million; 2021: £3,081 million) and £3,531 million (2022: £3,227 million; 2021: £2,670 million) respectively, after allocating final-customer discounts to the wholesalers. Revenue recognised in the year from performance obligations satisfied in previous periods totalled £1,751 million (2022: £1,601 million) including £728 million (2022: £898 million) impacting turnover arising from changes to prior year estimates of RAR (returns and rebates) accruals, £37 million (2022: £115 million) of milestone income and £986 million (2022: £588 million) of royalty income recognised in the current year. Segment profit Commercial Operations Research and development Segment profit Corporate and other unallocated costs Other reconciling items between segment profit and operating profit Total Operating profit Finance income Finance costs Gain/(loss) on disposal of interest in associates Share of after-tax profits/(losses) of associates and joint ventures Profit before taxation from continuing operations Taxation Profit after taxation for the year from continuing operations 2023 £m 2022 £m 2021 £m 14,656 13,590 11,467 (5,607) (5,060) (4,567) 9,049 (263) (2,041) 6,745 8,530 (379) (1,718) 6,433 115 76 (792) (879) 1 (5) – (2) 6,064 5,628 (756) 5,308 (707) 4,921 6,900 (407) (2,136) 4,357 14 (769) (36) 33 3,599 (83) 3,516 Other reconciling items between segment profit and operating profit comprise items not specifically allocated to segment profit. These include impairment and amortisation of intangible assets; major restructuring costs, which include impairments of tangible assets and computer software; transaction-related adjustments related to significant acquisitions; proceeds and costs of disposals of products and businesses, significant legal charges and expenses on the settlement of litigation and government investigations, other operating income other than royalty income and other items. Please refer to the detail of Other reconciling items between segment profit and operating profit in the analysis of adjusting items (Group financial review). Depreciation and amortisation by segment Commercial Operations Research and development Segment depreciation and amortisation Corporate and other unallocated depreciation and amortisation Other reconciling items between segment depreciation and amortisation and total depreciation and amortisation Total depreciation and amortisation 2023 £m 893 572 1,465 110 719 2,294 2022 £m 829 467 1,296 112 739 2,147 2021 £m 915 378 1,293 68 761 2,122 195 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 6. Turnover and segment information continued PP&E, intangible asset and goodwill impairment by segment Commercial Operations Research and development Segment impairment Corporate and other unallocated impairment Other reconciling items between segment impairment and total impairment Total impairment PP&E and intangible asset impairment reversals by segment Commercial Operations Research and development Segment impairment reversals Corporate and other unallocated impairment reversals Other reconciling items between segment impairment reversals and total impairment reversals Total impairment reversals Net operating assets by segment Commercial Operations Research and development Segment net operating assets Corporate and other unallocated net operating assets Net operating assets Net debt Investments in associates and joint ventures Current equity investment Derivative financial instruments Current and deferred taxation Assets held for sale (excluding cash and cash equivalents) Net assets 2023 £m 27 13 40 35 432 507 (16) (9) (25) (14) – (39) 2022 £m 29 32 61 20 420 501 (6) (19) (25) – (1) (26) 2021 £m 30 55 85 63 392 540 (8) (2) (10) – (2) (12) 2023 £m 12,302 7,021 19,323 625 19,948 2022 £m 10,288 7,299 17,587 264 17,851 (15,040) (17,197) 55 2,204 16 5,536 76 12,795 74 4,087 7 5,176 98 10,096 The Commercial Operations segment includes the Shionogi-ViiV Healthcare contingent consideration liability of £5,718 million (2022: £5,890 million) and the Pfizer put option of £848 million (2022: £1,093 million). Geographical information The UK is regarded as being the Group’s country of domicile. Turnover by location of customer UK US Rest of World External turnover Non-current assets by location of subsidiary UK US Belgium Rest of World Non-current assets 2023 £m 693 15,820 13,815 30,328 2022 £m 695 14,542 14,087 29,324 2023 £m 6,464 13,280 5,337 6,606 31,687 2021 £m 656 11,914 12,126 24,696 2022 £m 5,134 14,024 5,415 6,593 31,166 Non-current assets by location excludes amounts relating to other investments, deferred tax assets, derivative financial instruments, pension assets, amounts receivable under insurance contracts and certain other non-current receivables. There are no other countries with individually material external revenue or non-current assets. 196 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 7. Other operating income/(expense) Upfront settlement income(1) Fair value remeasurements of equity investments Disposal of businesses and assets 2023 £m – (122) 61 2022 £m 922 256 215 2021 £m – 37 552 Fair value remeasurements on contingent consideration recognised in business combinations (791) (1,607) (1,058) Remeasurement of ViiV Healthcare put option liabilities and preferential dividends Fair value adjustments on derivative financial instruments Other income 245 7 237 (85) 3 61 (48) (4) 17 (363) (235) (504) (1) On 1 February 2022, ViiV Healthcare reached agreement with Gilead Sciences, Inc (Gilead) to settle the global patent infringement litigation relating to the commercialisation of Gilead’s Biktarvy concerning ViiV Healthcare’s patents relating to dolutegravir, an anti-retroviral medication used, together with other medicines, to treat human immunodeficiency virus (HIV). Under the terms of the global settlement and licensing agreement, Gilead made an upfront payment of $1.25 billion (£922 million) to ViiV Healthcare on 15 February 2022. In addition, Gilead will also pay a 3% royalty on all future US sales of Biktarvy and in respect of the bictegravir component of any other future bictegravir-containing products sold in the US. These royalties will be payable by Gilead to ViiV Healthcare from 1 February 2022 until the expiry of ViiV Healthcare’s US Patent No. 8,129,385 on 5 October 2027 and will be recorded as royalty income in the income statement. Fair value remeasurement on equity investments in 2023 included a loss of £17 million from the remeasurement of the Group’s retained investment in Haleon plc. See details in Note 22 'Current equity investments'. Disposal of businesses and assets in 2023 primarily includes milestone income. Disposal of businesses and assets in 2022 includes milestone income and the reversal of provisions no longer required. Disposal of businesses and assets in 2021 included a net gain on disposal of the rights to the royalty stream for cabozantinib and a net gain on disposal of the cephalosporin antibiotic brands to Sandoz. Fair value re-measurements on contingent consideration recognised as business combinations included a net charge of £934 million related to the acquisition of the former Shionogi-ViiV Healthcare joint venture, £187 million net credit payable to Novartis related to the Vaccines acquisition, together with fair value movements on related hedging contracts and a charge of £44 million relating to the contingent consideration on the acquisition of Affinivax primarily relating to the unwind of the discount. Other income in 2023 primarily includes net income from dividends related to investments, including £49 million dividends received from the retained investment in Haleon plc. 197 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 8. Operating profit The following items have been included in operating profit: Employee costs (Note 9) Advertising Distribution costs Depreciation of property, plant and equipment Impairment of property, plant and equipment, net of reversals Depreciation of right of use assets Impairment of right of use assets Amortisation of intangible assets Impairment of intangible assets, net of reversals Impairment of tangible and intangible assets held for sale, net of reversals Net foreign exchange (gains)/losses Inventories: Cost of inventories included in cost of sales Write-down of inventories Reversal of prior year write-down of inventories Short-term lease charge Low-value lease charge Variable lease payments 2023 £m 8,473 835 199 892 17 190 10 1,212 418 23 11 6,576 979 2022 £m 7,693 735 192 885 70 176 40 1,086 365 – 11 6,137 687 (598) (483) 8 2 17 6 2 9 Fees payable to the company’s auditor and its associates in relation to the Group (see below) 22.0 26.9 2021 £m 7,680 433 169 855 87 179 5 1,088 435 1 (4) 5,885 800 (325) 7 3 10 31.7 The reversals of prior year write-downs of inventories principally arise from the reassessment of usage or demand expectations prior to inventory expiration. Net foreign exchange (gains)/losses include a net gain of £34 million (2022: £2 million loss; 2021: £35 million gain) arising from the recycling of exchange on liquidation or disposal of overseas subsidiaries. The recycling of exchange on disposal of overseas associates is £nil (2022: £nil). The recycling of exchange on disposal of overseas subsidiaries does not include recycling of exchange on disposal of Consumer Healthcare subsidiaries as this is reported as Profit after taxation on demerger of discontinued operations. Included within operating profit are Major restructuring charges of £382 million (2022: £321 million; 2021: £424 million), see Note 10, ‘Major restructuring costs’. Fees payable to the company’s auditor and its associates: Audit of parent company and consolidated financial statements including attestation under s.404 of Sarbanes-Oxley Act 2002 Audit of the company’s subsidiaries Total audit services Audit-related and other assurance services Total audit services, audit-related and other assurance services 2023 £m 10.2 10.2 20.4 1.6 22.0 2022 £m 10.9 9.7 20.6 6.3 26.9 2021 £m 13.2 14.5 27.7 4.0 31.7 The other assurance services provided by the auditor related to agreed upon procedures and other assurance services outside of statutory audit requirements. Audit related and other assurance services include £nil (2022: £4.4 million; 2021: £2.4 million) due to reporting accountant work performed in preparation for the Consumer Healthcare demerger. In addition to the above, fees paid to the auditor in respect of the GSK pension schemes were: Audit 2023 £m 0.2 2022 £m 0.2 2021 £m 0.2 198 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 9. Employee costs Wages and salaries Social security costs Pension and other post-employment costs, including augmentations (Note 31) Cost of share-based incentive plans Severance and other costs from integration and restructuring activities 2023 £m 6,706 818 356 321 272 2022 £m 6,110 763 369 314 137 2021 £m 5,858 793 415 345 269 8,473 7,693 7,680 The Group provides benefits to employees, commensurate with local practice in individual countries, including in some markets, healthcare insurance, subsidised car schemes and personal life assurance. The cost of share-based incentive plans is analysed as follows: Share value plan Performance share plan Share option plans Cash settled and other plans The average number of persons employed by the Group (including Directors) during the year: Manufacturing Selling, general and administration Research and development Total Continuing Operations Discontinued Operations Total 2023 £m 244 58 5 14 321 2022 £m 243 55 4 12 314 2021 £m 258 51 5 31 345 2023 Number 23,209 34,446 12,589 70,244 2022 Number 2021 Number 22,946 23,562 34,642 36,909 11,542 69,130 10,874 71,345 – 21,292 20,616 70,244 90,422 91,961 Note: Consumer Healthcare was divested on 18 July 2022 and is shown as Discontinued Operations in the above table. The average monthly number of Group employees excludes temporary and contract staff. The numbers of Group employees at the end of each financial year are given in the financial record on page 276. The compensation of the Directors and senior management (members of the GLT) in aggregate, was as follows: Wages and salaries Social security costs Pension and other post-employment costs Cost of share-based incentive plans 2023 £m 37 4 1 32 74 2022 £m 31 5 2 28 66 2021 £m 27 3 3 27 60 Further information on the remuneration of the Directors is given in the sections of the Annual Report on remuneration labelled as audited within pages 143 to 149. 199 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 10. Major restructuring costs Within the Pharmaceuticals sector, the highly regulated manufacturing operations and supply chains and long lifecycle of the business mean that restructuring programmes, particularly those that involve the rationalisation or closure of manufacturing or R&D sites, are likely to take several years to complete. Major restructuring costs are those related to specific Board-approved Major restructuring programmes, including integration costs following material acquisitions, which are structural and are of a significant scale where the costs of individual or related projects exceed £25 million. In January 2020, the Board approved a Separation Preparation programme to prepare for the separation of GSK into two companies. This programme is largely complete. After the acquisition of Sierra Oncology (July 2022) and Affinivax (August 2022), the Board approved a Major restructuring programme for the integration of significant acquisitions designed to integrate and achieve synergies. In June 2023 GSK acquired Bellus Health Inc. The total restructuring costs of £382 million in 2023 (2022: £321 million; 2021: £424 million) were incurred in the following areas: – Restructuring costs for separation of GSK into two companies – Continued transformation of central functions, including GSK technology platforms and interfaces, to deliver greater digital synergies, simplification of applications and staff reductions – The integration of acquisitions. The analysis of the costs charged to operating profit under these programmes was as follows: Increase in provision for Major restructuring programmes (see Note 32) Amount of provision reversed unused (see Note 32) Impairment losses recognised Other non-cash charges/(credit) Other cash costs 2023 £m 172 (55) 33 86 146 382 2022 £m 138 (111) 122 (7) 179 321 2021 £m 321 (140) 14 25 204 424 Provision reversals of £55 million reflected provision releases mainly related to the Separation Preparation programme. Asset impairments of £33 million and other non-cash charges of £86 million principally comprised fixed asset write-downs of manufacturing and administrative facilities and accelerated depreciation where asset lives have been shortened in the supply chain manufacturing network as a result of the Major restructuring programmes. All other charges have been or will be settled in cash and include site closure costs, consultancy and project management costs. The analysis of Major restructuring charges by programme was as follows: Separation Preparation programme Significant acquisitions Legacy programmes Separation Preparation programme Significant acquisitions Legacy programmes The analysis of Major restructuring charges by income statement line was as follows: Cost of sales Selling, general and administration Research and development Cash £m 199 65 (1) 263 Non-cash £m 117 1 1 119 Cash £m 177 20 9 206 2023 £m 164 216 2 382 Non-cash £m 110 – 5 115 2022 £m 102 180 39 321 2023 Total £m 316 66 – 382 2022 Total £m 287 20 14 321 2021 £m 102 277 45 424 200 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 11. Finance income Finance income arising from: Financial assets measured at amortised cost Financial assets measured at fair value through profit or loss Net gains arising from the forward element of forward contracts in net investment hedge relationships Other finance income 12. Finance expense Finance expense arising on: Financial liabilities at amortised cost Net losses arising from: Financial instruments mandatorily measured at fair value through profit or loss Retranslation of loans Reclassification of hedges from other comprehensive income Unwinding of discounts on provisions Finance expense arising on lease liabilities Other finance expense 2023 £m 2022 £m 2021 £m 48 60 – 7 115 31 31 12 2 76 11 2 – 1 14 2023 £m 2022 £m 2021 £m (672) (789) (735) (23) 25 (4) (15) (38) (65) (792) 743 (761) (2) (7) (30) (33) (879) (565) 565 (2) (2) (27) (3) (769) 201 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 13. Associates and joint ventures The Group’s share of after-tax profits and losses of associates and joint ventures is set out below: Share of after-tax (losses)/profits of associates Share of after-tax losses of joint ventures 2023 £m (2) (3) (5) 2022 £m 1 (3) (2) 2021 £m 36 (3) 33 During the year, the Group disposed of an investment in a joint venture for £nil consideration, with the release of related commitments for future capital contributions resulting in a net £1 million profit on disposal. In May 2021, the Group agreed with Innoviva Inc. to sell all of its shares in Innoviva back to Innoviva for £277 million. Following the disposal, at 31 December 2023, 31 December 2022 and 31 December 2021, the Group held no significant individual associates. Summarised income statement information in respect of Innoviva until May 2021 is set out below. The results of Innoviva included in the summarised income statement information below represent the estimated earnings of Innoviva in the relevant periods, based on publicly available information. Figures for 2021 include share of Innoviva’s turnover, profit and total comprehensive income until the date of the disposal. Turnover Profit after taxation Total comprehensive income Aggregated financial information in respect of GSK’s share of other associated undertakings and joint ventures is set out below: Share of after-tax losses Share of other comprehensive income/(expense) Share of total comprehensive income/(expense) 2023 £m (5) 7 2 2022 £m (2) (9) (11) The Group’s sales to associates and joint ventures were £nil in 2023 (2022: £nil; 2021: £nil). Please refer to the balance sheet information on Note 21, 'Investments in associates and joint ventures'. 2021 £m 108 106 106 2021 £m – 28 28 202 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 14. Taxation The Group’s tax charge is the sum of the total current and deferred tax expense. Taxation charge based on profits for the year UK current year charge Rest of World current year charge Charge/(credit) in respect of prior periods Current taxation Deferred taxation 2023 £m 207 1,371 43 1,621 (865) 756 2022 £m 200 1,351 (60) 1,491 (784) 707 2021 £m 119 593 219 931 (848) 83 In 2023, GSK made corporate income tax payments globally of £1.3 billion (2022: £1.5 billion), of which £205 million (2022: £48 million) was UK corporation tax paid to HMRC. These amounts are for corporate income tax only, and do not include the various other business taxes borne by GSK each year. The deferred tax credits in each period reflect current year losses where offset against taxable profits in future periods is probable and the release of deferred tax liabilities. The latter relates primarily to the unwind of deferred tax liabilities on intangible assets. The following table reconciles the tax charge calculated at the UK statutory rate on the Group profit before tax with the actual tax charge for the year. Reconciliation of taxation on Group profits Profit before tax UK statutory rate of taxation Differences in overseas taxation rates Benefit of intellectual property incentives R&D credits Permanent differences on disposals, acquisitions and transfers Other permanent differences Re-assessments of prior year current tax estimates Re-assessments of prior year deferred tax estimates Changes in tax rates Tax charge/tax rate 2023 £m 6,064 1,425 159 (696) (121) 10 102 43 (147) (19) 756 2023 % 23.5 2.6 (11.5) (2.0) 0.2 1.7 0.7 (2.4) (0.3) 12.5 2022 £m 5,628 1,069 318 (600) (119) 275 82 (60) (233) (25) 707 2022 % 19.0 5.6 (10.7) (2.1) 4.9 1.5 (1.1) (4.1) (0.4) 12.6 2021 £m 3,599 685 302 (382) (100) (3) (4) 219 (281) (353) 83 2021 % 19.0 8.4 (10.6) (2.8) (0.1) (0.1) 6.1 (7.8) (9.8) 2.3 As a global biopharmaceutical company, we have a substantial business and employment presence in many countries around the world. The impact of differences in overseas taxation rates arose from profits being earned in countries with tax rates higher than the UK statutory rate, the most significant of which in 2023 were Belgium and Japan. This adverse impact was offset by the benefit of intellectual property incentives such as the UK Patent Box and Belgian Innovation Income Deduction regimes, which provide a reduced rate of corporation tax on profits earned from qualifying patents. We claim these incentives in the manner intended by the relevant statutory or regulatory framework. Permanent differences on disposals, acquisitions and transfers in 2022 includes tax on internal restructuring to simplify the group structure. The Group’s tax rate is also influenced by updates to estimates of prior period tax liabilities following closure of open issues with tax authorities in various jurisdictions and changes in tax rates. The cumulative impact of these items in 2023 is a 2% reduction in the tax rate. In 2021, ‘Changes in tax rates’ included credits in relation to the enactment of the increase in the headline rate of UK corporate income tax from 19% to 25% (effective 2023). Future tax charges, and therefore our effective tax rate, may be affected by factors such as acquisitions, disposals, restructurings, the location of research and development activity, tax regime reforms and resolution of open matters as we continue to bring our tax affairs up to date around the world. During 2023 the UK Government substantively enacted legislation introducing a global minimum corporate income tax rate, to have effect from 2024 in line with the Organisation for Economic Co-operation and Development’s (OECD) Pillar Two model framework. We anticipate that the rules will restrict our ability to benefit from innovation incentives, such as the UK and Belgium Patent Box regimes, and consequently our underlying effective tax rate is forecast to increase by around 2% from 2024. 203 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 14. Taxation continued Tax on items charged to equity and statement of comprehensive income Current taxation Share-based payments Defined benefit plans Fair value movements on cash flow hedges Fair value movements on equity investments Deferred taxation Share-based payments Defined benefit plans Fair value movements on cash flow hedges Fair value movements on equity investments Total charge/(credit) to equity and statement of comprehensive income 2023 £m 2022 £m 2021 £m (1) (143) – (6) (150) (6) 184 (1) (8) 169 19 (3) – – 12 9 11 (211) (9) (68) (277) (268) – – 5 36 41 (11) 223 3 (167) 48 89 All of the above items have been charged to the statement of comprehensive income except for tax on share based payments. Issues relating to taxation The integrated nature of the Group’s worldwide operations involves significant investment in research and strategic manufacture at a limited number of locations, with consequential cross-border supply routes into numerous end-markets. In line with current OECD guidelines, we base our transfer pricing policy on the arm’s length principle and support our transfer prices with economic analysis and reports. However, different tax authorities may seek to attribute further profit to activities being undertaken in their jurisdiction potentially resulting in double taxation. The Group also has open items in several jurisdictions concerning such matters as the deductibility of particular expenses and the tax treatment of certain business transactions. GSK applies a risk based approach to determine the transactions most likely to be subject to challenge and the probability that the Group would be able to obtain compensatory adjustments under international tax treaties. The calculation of the Group’s total tax charge therefore necessarily involves a degree of estimation and judgement in respect of certain items whose tax treatment cannot be finally determined until resolution has been reached with the relevant tax authority or, as appropriate, through a formal legal process. At 31 December 2023 the Group had recognised provisions of £584 million in respect of such uncertain tax positions (2022: £551 million). The net increase in recognised provisions during 2023 was driven by the reassessment of estimates, the agreement of a number of open issues with tax authorities in various jurisdictions and amounts related to discontinued operations. Whilst the ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of agreements with the relevant tax authorities, or litigation where appropriate, the Group continues to consider that it has made appropriate provision for periods which are open and not yet agreed by the tax authorities. A provision for deferred tax liabilities of £165 million as at 31 December 2023 (2022: £157 million) has been made in respect of taxation that would be payable on the remittance of profits by certain overseas subsidiaries. Whilst the aggregate amount of unremitted profits at the balance sheet date was approximately £18 billion (2022: £16 billion), the majority of these unremitted profits would not be subject to tax (including withholding tax) on repatriation, as UK legislation relating to company distributions provides for exemption from tax for most overseas profits, subject to certain exceptions. Deferred tax is not provided on temporary differences of £869 million (2022: £660 million) arising on unremitted profits as management has the ability to control any future reversal and does not consider such a reversal to be probable. 204 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 14. Taxation continued Movement in deferred tax assets and liabilities At 1 January 2022 Exchange adjustments Credit/(charge) to income statement Credit/(charge) to statement of comprehensive income Acquisitions/Disposals R&D credits utilisation Transfer of assets for sale/distribution At 31 December 2022 Exchange adjustments Credit/(charge) to income statement Credit/(charge) to statement of comprehensive income Acquisitions/Disposals R&D credits utilisation At 31 December 2023 Accelerated capital allowances £m Intangible assets £m Contingent consideration £m Pensions & other post employment benefits £m Intra- Group profit £m Share option and award schemes £m Other net temporary differences £m Tax losses £m Total (211) (3,711) (29) (264) 122 126 850 – 142 999 (40) 258 640 1,450 64 6 91 1 (32) 104 (22) 1,554 1,662 160 190 (102) 888 – – (1) (637) – 62 – 3,667 – – – – – – – 182 – – 42 67 – (11) (12) 201 – – 76 (495) (76) (76) (118) (60) (8) (2) (250) 3,291 (57) (819) 992 1,099 794 1,661 11 72 – – – 58 229 – (144) – – (70) (24) (2) (71) 223 (15) 335 – – – – – – (184) – – – – – 26 (676) 921 1,252 571 1,994 57 – 12 5 – – 74 1,642 5,369 (100) (127) 80 865 10 – (169) (144) (56) (56) 1,576 5,738 Deferred tax liabilities in relation to intangible assets predominately relate to temporary differences arising as a result of historic business combinations. Acquisitions within the year predominantly relate to Bellus Health (see Note 41, 'Acquisitions and disposals'). The Group continues to recognise deferred tax assets on future obligations in respect of contingent consideration amounts payable to minority shareholders. These payments are tax deductible at the point in time at which payment is made. A deferred tax asset is recognised on intra-Group profits arising on inter-company inventory which are eliminated within the consolidated accounts. As intra-Group profits are not eliminated from the individual entities’ tax returns a temporary difference arises that will reverse at the point in time inventory is sold externally. The deferred tax asset of £1,994 million (2022: £1,661 million) recognised on tax losses relates to trading losses. Such deferred tax assets are only recognised to the extent Group long-range forecasts indicate sufficient future taxable profits will be available to utilise such assets by around 2030. Other net temporary differences included accrued expenses for which a tax deduction is only available on a paid basis. Deferred tax asset and liabilities are recognised on the balance sheet as follows: Deferred tax assets Deferred tax liabilities Unrecognised tax losses Trading losses expiring: Within 10 years More than 10 years Available indefinitely At 31 December Capital losses expiring: Available indefinitely At 31 December Deferred tax assets are only recognised where it is probable that future taxable profit will be available to utilise losses. 2023 £m 6,049 (311) 5,738 2022 £m 5,658 (289) 5,369 2022 Unrecognised deferred tax asset £m Tax losses £m 2023 Unrecognised deferred tax asset £m Tax losses £m 939 1,238 228 2,405 2,261 2,261 149 66 47 262 567 567 967 44 192 1,203 2,326 2,326 175 13 41 229 548 548 205 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 15. Earnings per share Basic earnings per share from continuing operations Basic earnings per share from discontinued operations Total basic earnings per share Diluted earnings per share from continuing operations Diluted earnings per share from discontinued operations Total diluted earnings per share 2023 pence 121.6 – 121.6 119.9 – 119.9 2022 pence 110.8 260.6 371.4 109.2 257.0 366.2 2021 pence 82.9 26.7 109.6 81.8 26.4 108.2 Basic earnings per share has been calculated by dividing the profit attributable to shareholders by the weighted average number of shares in issue during the period after deducting shares held by the ESOP Trusts for the future exercise of share options and share awards and Treasury shares. The trustees have waived their rights to cash dividends on the GSK shares held by the ESOP Trusts. Diluted earnings per share has been calculated after adjusting the weighted average number of shares used in the basic calculation to assume the conversion of all potentially dilutive shares. A potentially dilutive share forms part of the employee share schemes where its exercise price is below the average market price of GSK shares during the period and any performance conditions attaching to the scheme have been met at the balance sheet date. The numbers of shares used in calculating basic and diluted earnings per share are reconciled below. Weighted average number of shares in issue Basic Dilution for share options and awards Diluted 16. Dividends 2023 millions 4,052 59 4,111 2022 millions 4,026 58 4,084 2021 millions 4,003 49 4,052 First interim Paid/payable 13 July 2023 Second interim 12 October 2023 Third interim Fourth interim Total 11 January 2024 11 April 2024 Dividend per share (pence) 14.00 14.00 14.00 16.00 58.00 2023 Total dividend £m Dividend per share (pence) Paid 567 1 July 2022 568 6 October 2022 568 12 January 2023 649 2,352 13 April 2023 17.50 16.25 13.75 13.75 61.25 2022 Total dividend £m 704 654 Paid 8 July 2021 7 October 2021 555 13 January 2022 557* 7 April 2022 2,470 Dividend per share (pence) 23.75 23.75 23.75 28.75 100 2021 Total dividend £m 951 951 952 1,157 4,011 * The estimate for the fourth interim dividend for 2022 disclosed in the 2022 annual report was £555 million, £2 million less than the dividend that was ultimately paid. Under IFRS, interim dividends are only recognised in the financial statements when paid and not when declared. GSK normally pays a dividend two quarters after the quarter to which it relates and one quarter after it is declared. The 2023 financial statements recognise those dividends paid in 2023, namely the third and fourth interim dividends for 2022, and the first and second interim dividends for 2023. The demerger of Consumer Healthcare in 2022 was effected by GSK declaring an interim dividend in specie of Haleon plc shares. The fair value of the distribution was £15,526 million. The amounts recognised in each year were as follows: Cash dividends to shareholders Dividends in specie to shareholders in Haleon plc shares (Note 41) 2023 £m 2,247 – 2,247 2022 £m 3,467 15,526 18,993 2021 £m 3,999 – 3,999 206 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 17. Property, plant and equipment Cost at 1 January 2022 Exchange adjustments Additions through business combinations Other additions Capitalised borrowing costs Disposals and write-offs Reclassifications Transfer to assets held for sale/distribution Cost at 31 December 2022 Exchange adjustments Additions through business combinations Other additions Capitalised borrowing costs Disposals and write-offs Reclassifications Transfer to assets held for sale/distribution Cost at 31 December 2023 Depreciation at 1 January 2022 Exchange adjustments Charge for the year Disposals and write-offs Transfer to assets held for sale/distribution Depreciation at 31 December 2022 Exchange adjustments Charge for the year Disposals and write-offs Transfer to assets held for sale/distribution Reclassifications Depreciation at 31 December 2023 Impairment at 1 January 2022 Exchange adjustments Disposals and write-offs Impairment losses Reversal of impairments Transfer to assets held for sale/distribution Impairment at 31 December 2022 Exchange adjustments Disposals and write-offs Impairment losses Reversal of impairments Transfer to assets held for sale/distribution Reclassifications Impairment at 31 December 2023 Total depreciation and impairment at 31 December 2022 Total depreciation and impairment at 31 December 2023 Net book value at 1 January 2022 Net book value at 31 December 2022 Net book value at 31 December 2023 Land and buildings £m Plant, equipment and vehicles £m Assets in construction £m 7,212 403 5 13 – 11,816 542 8 79 – (64) 146 (222) 689 (1,067) (1,959) 6,648 10,953 (189) (265) – 11 – (136) 134 (13) – 99 – (732) 701 (52) 1,750 105 17 1,153 21 (5) (874) (317) 1,850 (44) – 1,185 36 (16) (869) (22) Total £m 20,778 1,050 30 1,245 21 (291) (39) (3,343) 19,451 (498) – 1,295 36 (884) (34) (87) 6,455 10,704 2,120 19,279 (3,281) (6,744) (191) (226) 47 376 (310) (726) 181 1,130 (3,275) (6,469) 90 153 (210) (682) 66 6 – 662 29 (4) (3,323) (6,311) (264) (9) 9 (33) – 37 (514) (14) 47 (45) 9 45 – – – – – – – – – – – – (43) (1) 5 (5) – 2 (10,025) (501) (952) 228 1,506 (9,744) 243 (892) 728 35 (4) (9,634) (821) (24) 61 (83) 9 84 (260) (472) (42) (774) 4 27 (11) 3 – – (237) (3,535) (3,560) 3,667 3,113 2,895 7 114 (32) 23 – – (360) (6,941) (6,671) 4,558 4,012 4,033 1 13 – – – – 12 154 (43) 26 – – (28) (42) (28) 1,707 1,808 2,092 (625) (10,518) (10,259) 9,932 8,933 9,020 207 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 17. Property, plant and equipment continued The weighted average interest rate for capitalised borrowing costs in the year was 4% (2022: 4%). Disposals and write-offs in the year included a number of assets with nil net book value that are no longer in use in the business. The impairment losses principally arose from decisions to rationalise facilities and were calculated based on fair value less costs of disposal. The fair value less costs of disposal valuation methodology uses significant inputs which are not based on observable market data, and therefore this valuation technique is classified as level 3 of the fair value hierarchy. These calculations determine the net present value of the projected risk-adjusted, post-tax cash flows of the relevant asset or cash generating unit, applying a discount rate of the Group post-tax weighted average cost of capital (WACC) of 7%, adjusted where appropriate for specific segment, country and currency risk. Assets that continue to be used by the Group are generally assessed as part of their associated cash generating unit on a value in use basis. For value in use calculations, the post-tax cash flows do not include the impact of future uncommitted restructuring plans or improvements. Where an impairment is indicated and a pre-tax cash flow calculation is expected to give a materially different result, the test would be reperformed using pre-tax cash flows and a pre-tax discount rate. The Group WACC is equivalent to a pre- tax discount rate of approximately 9%. Net impairment reversals have been credited to cost of sales: £1 million (2022: net impairment losses £11 million) and R&D: £5 million (2022: net impairment losses £7 million). Net impairment losses have been charged to SG&A: £23 million (2022: £55 million), after charging impairment losses of £27 million (2022: £34 million) arising from the Major restructuring programmes. Reversals of impairment arose from subsequent reviews of the impaired assets where the conditions which gave rise to the original impairments were deemed no longer to apply. £17 million of the impairment reversal has been credited to cost of sales, £5 million of the impairment reversal has been credited to R&D expenses and £4 million of the impairment reversal has been credited to SG&A. During 2022, the full impairment reversal of £9 million was credited to cost of sales. During 2023, £34 million (2022: £39 million) of computer software was reclassified from assets in construction to intangible assets on becoming ready for use. The Group has assessed the qualitative and quantitative impact of climate related risks on asset recoverable amounts and concluded that there are no material impairments. As of 31 December 2023, £53 million has been capitalised in property, plant and equipment regarding the transition to a lower-carbon propellant. 18. Right of use assets Net book value at 1 January 2022 Exchange adjustments Additions through business combinations Other additions Depreciation Transfer to assets held for sale/distribution Disposals Impairments Net book value at 31 December 2022 Exchange adjustments Additions through business combinations Other additions Depreciation Transfer to assets held for sale/distribution Disposals Impairments Reclassifications Net book value at 31 December 2023 Land and buildings £m Plant and equipment £m Vehicles £m 633 47 53 140 (131) (115) (27) (39) 561 (30) 1 355 (121) – (11) (10) 6 751 9 – – 2 (3) (1) (1) – 6 – – – (2) – – – – 4 98 8 – 91 (58) (11) (8) – 120 (6) – 144 (67) – (9) – – 182 Total £m 740 55 53 233 (192) (127) (36) (39) 687 (36) 1 499 (190) – (20) (10) 6 937 The Group has entered into some commitments for lease contracts that have not yet commenced. See Note 36, 'Commitments'. An analysis of lease liabilities is set out in Note 30, ‘Net debt’. 208 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 19. Goodwill Cost at 1 January Exchange adjustments Additions through business combinations (Note 41) Other movements (Note 41) Transfer to assets held for sale/distribution Cost at 31 December Net book value at 1 January Net book value at 31 December All goodwill is allocated to the Group’s segments as follows: Commercial operations Total R&D Net book value at 31 December 2023 £m 7,046 (313) 109 (31) 2022 £m 10,552 550 1,127 – – (5,183) 6,811 7,046 6,811 7,046 10,552 7,046 2023 £m 5,951 860 6,811 2022 £m 6,148 898 7,046 The recoverable amounts of the cash generating units are assessed using a fair value less costs of disposal model. Fair value less costs of disposal is calculated using a discounted cash flow approach, with a post-tax discount rate applied to the projected risk- adjusted post-tax cash flows and terminal value. The discount rate used is based on the Group WACC of 7% (2022: 7%), as most cash generating units have integrated operations across large parts of the Group. The discount rate is adjusted where appropriate for specific segment, country and currency risks. The valuation methodology uses significant inputs which are not based on observable market data, therefore this valuation technique is classified as level 3 in the fair value hierarchy. The R&D segment is evaluated on an arm's length pricing model, see assumptions below. Details relating to the discounted cash flow models used in the impairment tests are as follows: Valuation basis Key assumptions Determination of assumptions Fair value less costs of disposal Sales growth rates Profit margins Terminal growth rate Discount rate Taxation rate Growth rates are internal forecasts based on both internal and external market information. Margins reflect past experience, adjusted for expected changes. Terminal growth rates based on management’s estimate of future long-term average growth rates. Discount rates based on Group WACC, adjusted where appropriate. Taxation rates based on appropriate rates for each jurisdiction. Period of specific projected cash flows Five years Terminal growth rate and discount rate Terminal growth rate Discount rate 2023 Commercial operations R&D 2022 Commercial operations R&D 0% p.a 0% p.a 0% p.a 0% p.a 7% p.a 7% p.a 7% p.a 7% p.a The terminal growth rate does not exceed the long-term projected growth rates for relevant markets, reflects the impact of future generic competition and take account of new product launches. Goodwill is monitored for impairment at the segmental level and the valuations indicated sufficient headroom such that a reasonably possible change to key assumptions is unlikely to result in an impairment of the related goodwill. The Group has assessed the qualitative and quantitative impact of climate related risks on asset recoverable amounts and concluded that there are no material impairments. 209 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 20. Other intangible assets Cost at 1 January 2022 Exchange adjustments Capitalised development costs Additions through business combinations Other additions Disposals and asset write-offs Transfer to assets held for sale/distribution Reclassifications Cost at 31 December 2022 Exchange adjustments Capitalised development costs Additions through business combinations Other additions Disposals and asset write-offs Transfer to assets held for sale/distribution Reclassifications Cost at 31 December 2023 Amortisation at 1 January 2022 Exchange adjustments Charge for the year Disposals and asset write-offs Transfer to assets held for sale Amortisation at 31 December 2022 Exchange adjustments Charge for the year Disposals and asset write-offs Transfer to assets held for sale/distribution Reclassifications Amortisation at 31 December 2023 Impairment at 1 January 2022 Exchange adjustments Impairment losses Transfer to assets held for sale/distribution Reversal of impairments Disposals and asset write-offs Impairment at 31 December 2022 Exchange adjustments Impairment losses Transfer to assets held for sale/distribution Reversal of impairments Disposals and asset write-offs Impairment at 31 December 2023 Total amortisation and impairment at 31 December 2022 Total amortisation and impairment at 31 December 2023 Net book value at 1 January 2022 Net book value at 31 December 2022 Net book value at 31 December 2023 Computer software £m 2,424 Licences, patents, amortised brands £m 21,439 63 – – 149 (203) (513) 39 1,959 (30) – – 144 (125) 2 34 1,984 (1,369) (33) (204) 129 254 (1,223) 18 (203) 100 (3) 4 934 317 2,964 626 (33) (496) (34) 25,717 (664) 363 1,438 525 (13) – (3) 27,363 (8,262) (307) (931) 19 300 (9,181) 174 (1,009) 8 – 1 (1,307) (10,007) (91) (2) (72) 10 1 73 (81) 1 (23) – 3 25 (2,480) (138) (313) 34 17 7 (2,873) 70 (398) – – 11 (75) (3,190) (1,304) (1,382) 964 655 602 (12,054) (13,197) 10,697 13,663 14,166 Indefinite life brands £m 18,626 1,112 – – – – (19,772) 34 – – – – – – – – – – – – – – – – – – – – – (208) (1) (17) 226 – – – – – – – – – – – 18,418 – – Total £m 42,489 2,109 317 2,964 775 (236) (20,781) 39 27,676 (694) 363 1,438 669 (138) 2 31 29,347 (9,631) (340) (1,135) 148 554 (10,404) 192 (1,212) 108 (3) 5 (11,314) (2,779) (141) (402) 270 18 80 (2,954) 71 (421) – 3 36 (3,265) (13,358) (14,579) 30,079 14,318 14,768 The weighted average interest rate for capitalised borrowing costs in the year was 4% (2022: 4%). The net book value of computer software included £270 million (2022: £479 million) of internally generated costs. The carrying value at 31 December 2023 of intangible assets, for which impairments have been charged in the year following those impairments, was £533 million (2022: £83 million), resulting from the appraisal of GSK’s assumptions related to in-licences and collaboration agreements. The carrying value at 31 December 2023 of intangible assets, for which impairment reversals have been charged in the year following those impairment reversals, was £nil million (2022: £776 million). No individual intangible asset accounted for a material impairment. 210 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 20. Other intangible assets continued The patent expiry dates of the Group’s most significant assets, where relevant, are set out on pages 281 to 283. Please refer to Note 2, 'Accounting principles and policies' to the Group’s accounting policy and estimate of the useful life for intangible assets over the exclusivity and non-exclusivity periods. Amortisation and impairment losses, net of reversals, have been charged in the income statement as follows: Cost of sales Selling, general and administration Research and development Amortisation Net impairment losses 2023 £m 668 103 441 1,212 2022 £m 663 116 307 1,086 2023 £m 1 18 399 418 2022 £m 2 66 299 367 Licences, patents, amortised brands etc. includes a large number of acquired licences, patents, know-how agreements and marketing rights, which are either marketed or in use, or still in development. Note 41, ‘Acquisitions and disposals’ gives details of additions through business combinations in the year. The book values of the largest individual items are as follows: Tesaro Assets Meningitis Portfolio Momelotinib Camlipixant Affinivax Assets Dolutegravir (including Cabotegravir) Iteos Assets Alector Assets Benlysta Shingrix Okairos BMS Assets CureVac Assets Spero RSV Relvar/Breo/Anoro Stiefel Trade Name Wave Life Sciences UCB Arrowhead DT Fluarix/FluLaval Vir Assets Others 2023 £m 2,656 1,717 1,470 1,438 1,429 1,059 443 425 424 289 198 191 191 163 139 125 116 116 115 114 104 100 1 2022 £m 2,858 1,855 1,499 – 1,473 1,150 443 509 541 288 202 196 178 163 40 181 142 – 137 90 115 147 159 1,143 14,166 1,297 13,663 After announcement on 13 December 2022, GSK and Wave Life Sciences Ltd. entered into a strategic collaboration in January 2023, to advance oligonucleotide therapeutics focusing on novel genetic targets. On 28 June 2023, GSK has completed the acquisition of Bellus Health Inc, a late-stage biopharmaceutical company. The acquisition provides GSK access to camlipixant. (Refer to Note 41, 'Acquisitions and disposals'). The Group does not consider that any reasonably possible changes in the key assumptions would cause the recoverable amount of the intangible assets disclosed above to fall below their carrying values. The Group has assessed the qualitative and quantitative impact of climate related risks on asset recoverable amounts and concluded that there are no material impairments. 211 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 21. Investments in associates and joint ventures At 1 January Exchange adjustments Additions Disposals Distributions received Net fair value movements through other comprehensive income Impairment of interest in associates Profit/(loss) after tax recognised in the consolidated income statement At 31 December Joint ventures £m Associates £m 2023 Total £m Joint ventures £m Associates £m 10 – – (7) – – – (3) – 64 (3) – – (11) 7 – (2) 55 74 (3) – (7) (11) 7 – (5) 55 12 1 – – – – – (3) 10 76 1 1 – (6) (9) – 1 64 2022 Total £m 88 2 1 – (6) (9) – (2) 74 During the year, the Group disposed of an investment in a joint venture for £nil consideration. Please refer to the income statement information in Note 13, 'Associates and joint ventures'. 22. Current equity investments Current At 1 January Additions Net fair value movements through profit or loss Disposals and Settlements Exchange adjustments At 31 December Investments measured at FVTPL 2023 £m Investments measured at FVTPL 2022 £m 4,087 – (17) (1,863) (3) – 3,852 233 – 2 2,204 4,087 Current equity investments represent Haleon plc shares held after the demerger of Consumer Healthcare. Shares are held for trading and measured at fair value through profit or loss (FVTPL) based on the Haleon plc share price. Changes in fair value are presented as Other operating income/(expense) in continuing operations. The Group’s investment in Haleon plc at the end of December 2023 is held by Glaxo Group Limited, 2.8% (2022: 5.4%), GSK Scottish Limited Partnership (No.1), 4.6% (2022: 4.7%), GSK Scottish Limited Partnership (No.2), nil (2022: 1.8%), GSK Scottish Limited Partnership (No.3), nil (2022: 1.0%) and the ESOP Trusts, nil (2022: 0.6%). 212 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 23. Other investments Non-current 1 January Exchange adjustments Additions Net fair value movements through other comprehensive income Net fair value movements through profit or loss Held for sale Disposals 31 December Investments designated as measured at FVTOCI £m Investments measured at FVTPL £m 1,153 (26) 93 (253) – (16) (20) 931 314 (15) 29 – (122) – – 206 Investments designated as measured at FVTOCI £m Investments measured at FVTPL £m 1,927 75 87 (716) – – (220) 1,153 199 25 63 – 27 – – 314 2023 £m 1,467 (41) 122 (253) (122) (16) (20) 1,137 2022 £m 2,126 100 150 (716) 27 – (220) 1,467 Non-current other investments comprise non-current equity investments which are recorded at fair value at each balance sheet date. For investments traded in an active market, the fair value is determined by reference to the relevant stock exchange quoted bid price. For other investments, the fair value is estimated by management with reference to relevant available information, including the current market value of similar instruments, recent financing rounds and discounted cash flows of the underlying net assets. Net fair value movements include the impact of exchange losses of £37 million through Other comprehensive income and £nil through profit or loss (2022: gains of £134 million through Other comprehensive income and £nil through profit or loss). Other investments include listed investments of £741 million (2022: £823 million). GSK has elected to designate the majority of its equity investments as measured at fair value through Other comprehensive income (FVTOCI). The most significant of these investments held at 31 December 2023 were in Crispr Therapeutics AG, which had a fair value at 31 December 2023 of £158 million (2022: £109 million) and Vir Biotechnology.Inc. which had a fair value at 31 December 2023 of £67 million (2022: £180 million). The fair value of the investment in Nimbus Therapeutics, LLC, disclosed as a significant investment at 31 December 2022, was £5 million at 31 December 2023 (2022: £139 million). The other investments include equity stakes in companies with which GSK has research collaborations and in companies which provide access to biotechnology developments of potential interest. On disposal of equity investments measured at FVTOCI, the accumulated fair value movements are reclassified from the fair value reserve to retained earnings. Investments measured at FVTOCI with a fair value of £20 million (2022: £220 million) were disposed of during the year. The cumulative loss on these investments after tax was £26 million (2022: gain of £14 million). Certain other investments, such as investments in funds with limited lives and investments acquired with an intention to sell, are measured at fair value through profit or loss (FVTPL). The most significant of these investments held at 31 December 2023 was SR One Capital Fund I-B, LP which had a fair value at 31 December 2023 of £102 million (2022: £211 million). 24. Other non-current assets Amounts receivable under insurance contracts Pension schemes in surplus Other receivables 2023 £m 854 634 96 1,584 2022 £m 857 229 108 1,194 Amounts receivable under insurance contracts are held at cash surrender value with movements through profit or loss. Within the other receivables of £96 million (2022: £108 million), £27 million (2022: £34 million) is classified as financial assets of which £18 million (2022: £13 million) is classified as fair value through profit or loss. On the remaining balance of £9 million (2022: £21 million), the expected credit loss allowance was immaterial at 31 December 2023 and 2022. Other receivables include £7 million relating to carbon-based nature removal projects (2022: £2 million). 213 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 25. Inventories Raw materials and consumables Work in progress Finished goods 2023 £m 1,594 2,449 1,455 5,498 2022 £m 1,576 2,286 1,284 5,146 As part of the TCFD one of the climate-related risks identified affects the metered dose inhalers (MDI). There is no impact on the recoverable value of the associated inventories held at year end. 26. Trade and other receivables Trade receivables, net of loss allowance Accrued income Prepayments Interest receivable Employee loans and advances Other receivables 2023 £m 5,905 69 355 2 9 1,045 7,385 2022 £m 5,452 19 343 2 11 1,226 7,053 There were no trade or other receivable balances (2022: £nil) due from associates and joint ventures. The most significant component of other receivables comprises receivables for indirect and other taxes of £565 million (2022: £492 million). Other significant balances within other receivables are royalties receivable of £226 million (2022: £188 million) and an amount receivable from collaboration partners of £nil (2022: £263 million). Loss allowance - trade receivables At 1 January Exchange adjustments Charge for the year Transfer to assets held for sale Subsequent recoveries of amounts provided for Utilised At 31 December 2023 £m 91 (6) 11 – (9) (2) 85 2022 £m 150 9 35 (60) (19) (24) 91 Of the total trade receivables balance, £10 million (2022: £58 million) is considered credit impaired, against which a £8 million (2022: £26 million) expected credit loss allowance has been applied. No amount was purchased or originated credit impaired. Within the other receivables of £1,045 million (2022: £1,226 million), £408 million (2022: £683 million) is classified as financial assets of which £nil (2022: £nil) is classified as held at fair value through profit or loss. At 31 December 2023, an expected credit loss allowance of £3 million (2022: £6 million) was recognised in respect of financial assets, with a release in expected credit loss allowance of £3 million (2022: £nil) reported in profit or loss during the year. For more discussion on credit risk practices, please refer to Note 44, 'Financial instruments and related disclosures'. 214 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 27. Cash and cash equivalents Cash at bank and in hand Cash equivalents 2023 £m 748 2,188 2,936 2022 £m 879 2,844 3,723 Cash and cash equivalents included £190 million (2022: £200 million) not available for general use due to restrictions applying in the subsidiaries where it is held. Restrictions include exchange controls and taxes on repatriation. During 2022, £1,421 million was transferred to assets held for sale relating to Consumer Healthcare which was demerged during that year (see Note 41, 'Acquisitions and disposals'). 28. Assets held for sale Property, plant and equipment Other 2023 £m 60 16 76 2022 £m 83 15 98 Non-current assets and disposal groups are transferred to assets held for sale when it is expected that their carrying amounts will be recovered principally through disposal and a sale is considered highly probable. They are held at the lower of carrying amount and fair value less costs to sell. 215 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 29. Trade and other payables Trade payables Wages and salaries Social security ViiV Healthcare put option Other payables Deferred income Customer return and rebate accruals Other accruals 2023 £m 3,717 1,683 126 848 346 222 6,799 2,103 15,844 2022 £m 3,866 1,488 126 1,093 418 299 6,627 2,346 16,263 Trade and other payables included £nil (2022: £nil) due to associates and joint ventures. The Group provides limited supplier financing arrangements to certain suppliers. The amounts involved at 31 December 2023 were not material. Revenue recognised in the year that was included in deferred income at 1 January 2023 was £192 million (2022: £85 million). Customer return and rebate accruals are provided for by the Group at the point of sale in respect of estimated rebates, discounts or allowances payable to customers as more fully described in the Group financial review on page 105. At 31 December 2023, customer return and rebate accruals included £5,781 million (2022: £5,717 million) in respect of US Commercial Operations. Accruals are made at the time of sale but the actual amounts paid are based on claims made some time after the initial recognition of the sale. As the amounts are estimated, they may not fully reflect the final outcome and are subject to change dependent upon, amongst other things, the types of buying group and product sales mix. The level of accrual is reviewed and adjusted quarterly in light of historical experience of actual amounts paid and any changes in arrangements. Future events could cause the assumptions on which the accruals are based to change, which could affect the future results of the Group. Pfizer’s put option over its shareholding in ViiV Healthcare is currently exercisable. Pfizer may request an IPO of ViiV Healthcare at any time and if either GSK does not consent to such IPO or an offering is not completed within nine months, Pfizer could require GSK to acquire its shareholding. The amount of the liability for this put option, which is held on the gross redemption basis, is derived from an internal valuation of the ViiV Healthcare business, utilising both discounted forecast future cash flow and multiples-based methodologies. The table below shows on an indicative basis the income statement and balance sheet sensitivity of the Pfizer put option to reasonably possible changes in key assumptions. Increase/(decrease) in financial liability and loss/(gain) in Income statement 10% increase in sales forecasts* 15% increase in sales forecasts* 10% decrease in sales forecasts* 15% decrease in sales forecast* 1% (100 basis points) increase in discount rate 1.50% (150 basis points) increase in discount rate 1% (100 basis points) decrease in discount rate 1.50% (150 basis points) decrease in discount rate 10 cent appreciation of US Dollar 15 cent appreciation of US Dollar 10 cent depreciation of US Dollar 15 cent depreciation of US Dollar 10 cent appreciation of Euro 15 cent appreciation of Euro 10 cent depreciation of Euro 15 cent depreciation of Euro 2023 £m 84 126 (84) (126) (18) (26) 19 28 54 85 (46) (67) 22 34 (18) (26) * The sales forecast is for ViiV Healthcare sales only in respect of the ViiV Healthcare put option. Other accruals includes interest accrued on financial liabilities at amortised cost of £162 million  (2022: £207 million). An explanation of the accounting for ViiV Healthcare is set out on page 84. 2022 £m 100 149 (99) (149) (32) (48) 35 53 66 103 (56) (80) 29 46 (24) (35) 216 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 30. Net debt Current assets: Liquid investments Cash and cash equivalents Short-term borrowings: Commercial paper Bank loans, overdrafts and other 0.125% € Euro Medium Term Note 2023 0.000% € Euro Medium Term Note 2023 0.534% US$ Medium Term Note 2023 3.000% US$ US Medium Term Note 2024 1.375% € Euro Medium Term Note 2024 Lease liabilities Long-term borrowings: Listing exchange London Stock Exchange London Stock Exchange New York Stock Exchange New York Stock Exchange London Stock Exchange 3.000% US$ US Medium Term Note 2024 New York Stock Exchange 1.375% € Euro Medium Term Note 2024 4.000% € Euro Medium Term Note 2025 London Stock Exchange London Stock Exchange 3.625% US$ US Medium Term Note 2025 New York Stock Exchange 1.000% € Euro Medium Term Note 2026 1.250% € Euro Medium Term Note 2026 3.000% € Euro Medium Term Note 2027 3.375% £ Euro Medium Term Note 2027 London Stock Exchange London Stock Exchange London Stock Exchange London Stock Exchange 2023 £m 42 2,936 2,978 (815) (191) – – – (784) (867) (156) 2022 £m 67 3,723 3,790 (1,191) (448) (665) (443) (1,038) – – (167) (2,813) (3,952) – – (650) (783) (608) (867) (434) (306) (829) (884) (663) (827) (620) (885) (442) (306) 3.875% US$ US Medium Term Note 2028 New York Stock Exchange (1,370) (1,450) 0.883% ¥ Euro Medium Term Note 2028 1.250% £ Euro Medium Term Note 2028 London Stock Exchange London Stock Exchange 3.375% US$ US Medium Term Note 2029 New York Stock Exchange 1.375% € Euro Medium Term Note 2029 1.750% € Euro Medium Term Note 2030 3.125% € Euro Medium Term Note 2032 5.250% £ Euro Medium Term Note 2033 5.375% US$ US Medium Term Note 2034 1.625% £ Euro Medium Term Note 2035 6.375% US$ US Medium Note 2038 6.375% £ Euro Medium Term Note 2039 5.250% £ Euro Medium Term Note 2042 4.200%US$ US Medium Term Note 2043 4.250% £ Euro Medium Term Note 2045 Other long-term borrowings Lease liabilities Net debt London Stock Exchange London Stock Exchange London Stock Exchange London Stock Exchange London Stock Exchange London Stock Exchange New York Stock Exchange London Stock Exchange London Stock Exchange New York Stock Exchange London Stock Exchange (235) (745) (778) (433) (650) (604) (566) (390) (745) – (744) (822) (441) (663) (616) (640) (412) (744) (2,139) (2,264) (627) (472) (385) (366) (1) (1,051) (695) (472) (408) (366) (1) (841) (15,205) (17,035) (15,040) (17,197) 217 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 30. Net debt continued Current assets Liquid investments are classified as financial assets at amortised cost. At 31 December 2023, they included US Treasury Notes and other government bonds. The effective interest rate on liquid investments at 31 December 2023 was approximately 0.9% (2022: approximately 0.1%). Liquid investment balances at 31 December 2023 earning interest at floating rates amount to £31 million (2022: £67 million). Liquid investment balances at 31 December 2023 earning interest at fixed rates amount to £11 million (2022: £nil). Balances reported within cash and cash equivalents have an original maturity of three months or less. The effective interest rate on cash and cash equivalents at 31 December 2023 was approximately 4.7% (2022: approximately 3.1%). Cash and cash equivalents at 31 December 2023 earning interest at floating and fixed rates amounted to £2,720 million and £38 million respectively (2022: £3,441 and £10 million) and non-interest bearing holdings amounted to £178 million (2022: £272 million). GSK’s policy regarding the credit quality of cash and cash equivalents is set out in Note 44, ‘Financial instruments and related disclosures’. Short-term borrowings GSK has a $10 billion (£7.8 billion) US commercial paper programme, of which $850 million (£667 million) was in issue at 31 December 2023 (2022: $900 million (£748 million)). GSK has a £5 billion Euro commercial paper programme, of which €170 million (£148 million) was in issue at 31 December 2023 (2022: €500 million (£443 million)). GSK has a £1.6 billion three-year committed facility and $2.2 billion (£1.7 billion) 364 day committed facility. The three-year committed facility was agreed in February 2022 and extended by one year in August 2023 to September 2026. The 364-day committed facility was agreed in September 2023. These facilities were undrawn at 31 December 2023. The weighted average interest rate on commercial paper borrowings at 31 December 2023 was 5.1% (2022: 3.5%). The weighted average interest rate on current bank loans and overdrafts at 31 December 2023 was 4.6% (2022: 7.8%). The average effective pre-swap interest rate of notes classified as short-term at 31 December 2023 was 2.4% (2022: 0.4%). Long-term borrowings At the year-end, GSK had long-term borrowings of £15.2 billion (2022: £17.0 billion), of which £8.7 billion (2022: £11.1 billion) fell due in more than five years. During 2023 through a bilateral buyback for outstanding Sterling Notes, GSK repurchased £76m of the 5.250% £ Euro Medium Term Note 2033 and £69m of the 6.375% £ Euro Medium Term Note 2039. The average effective pre-swap interest rate of all notes in issue at 31 December 2023 was approximately 3.7% (2022: approximately 3.5%). Long-term borrowings repayable after five years carry interest at effective rates between 1.5% and 6.6%, with repayment dates ranging from 2029 to 2045. Both effective rates exclude the impact of one-off premiums associated with the early repayment of the Sterling Notes. Pledged assets The Group held pledged investments in US Treasury Notes with a par value of $54 million (£42 million), (2022: $56 million (£47 million)) as security against irrevocable letters of credit issued on the Group’s behalf in respect of the Group’s self-insurance activity. Provisions in respect of self-insurance are included within the provisions for legal and other disputes discussed in Note 32, 'Other provisions’. Lease liabilities The maturity analysis of discounted lease liabilities recognised on the Group balance sheet is as follows: Rental payments due within one year Rental payments due between one and two years Rental payments due between two and three years Rental payments due between three and four years Rental payments due between four and five years Rental payments due after five years Total lease liabilities 2023 £m 156 214 134 114 88 501 1,207 2022 £m 167 201 127 97 80 336 1,008 218 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits Pension and other post-employment costs UK pension schemes US pension schemes Other overseas pension schemes Unfunded post-retirement healthcare schemes Analysed as: Funded defined benefit/hybrid pension schemes Unfunded defined benefit pension schemes Unfunded post-retirement healthcare schemes Defined benefit schemes Defined contribution pension schemes 2023 £m 96 56 146 58 356 134 35 58 227 129 356 2022 £m 114 48 154 53 369 152 31 53 236 133 369 2021 £m 185 40 153 37 415 231 23 37 291 124 415 The costs of the defined benefit pension and post-retirement healthcare schemes are charged in the income statement as follows: Cost of sales Selling, general and administration Research and development 2023 £m 94 91 42 227 2022 £m 104 90 42 236 2021 £m 106 136 49 291 GSK entities operate pension arrangements which cover the Group’s material obligations to provide pensions to retired employees. These arrangements have been developed in accordance with local practices in the countries concerned. Pension benefits can be provided by state schemes; by defined contribution schemes, whereby retirement benefits are determined by the value of funds arising from contributions paid in respect of each employee; or by defined benefit schemes, whereby retirement benefits are based on employee pensionable remuneration and length of service. Pension costs of defined benefit schemes for accounting purposes have been calculated using the projected unit credit method. In certain countries pension benefits are provided on an unfunded basis, some administered by trustee companies. Formal, independent, actuarial valuations of the Group’s main plans are undertaken regularly, normally at least every three years. Remeasurement movements in the year are recognised through the statement of comprehensive income. Discount rates are derived from AA rated corporate bond yields except in countries where there is no deep market in corporate bonds where government bond yields are used. Discount rates are selected to reflect the term of the expected benefit payments. Projected inflation rates and pension increases are long-term predictions based on the yield gap between long-term index-linked and fixed interest government bonds. In the UK, mortality rates are determined by adjusting the SAPS S3 standard mortality tables to reflect recent scheme experience. These rates are then projected to reflect improvements in life expectancy in line with the CMI 2022 projections with a long-term rate of improvement of 1.0% per year for both males and females. In the US, mortality rates are calculated using the PRI-2012 white collar table adjusted to reflect recent experience. These rates are projected using MP-2020 to allow for future improvements in life expectancy. 219 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued The average life expectancy assumed now for an individual at the age of 60 and projected to apply in 2043 for an individual then at the age of 60 is as follows: Current Projected for 2043 Male Years 27.1 28.2 UK Female Years 28.0 29.2 Male Years 27.3 28.9 US Female Years 28.7 30.2 The assets of funded schemes are generally held in separately administered trusts, either as specific assets or as a proportion of a general fund, or are insurance contracts. Assets are invested in different classes in order to maintain a balance between risk and return. Investments are diversified to limit the financial effect of the failure of any individual investment. The physical asset allocation strategy for three of the four UK plans is 36% in return-seeking assets and 64% in liability-matching assets. During 2019, a buy-in insurance contract was purchased to cover substantially all of the obligations of the other UK plan. At 31 December 2023, the value of the insurance contract was £387 million (2022: £402 million). The asset allocation of the US plans is currently set at 25% return- seeking assets and 75% liability-matching assets. The pension plans are exposed to risk that arises because the estimated market value of the plans’ assets might decline, the investment returns might reduce, or the estimated value of the plans’ liabilities might increase. In line with the agreed mix of return-seeking assets to generate future returns and liability-matching assets to better match future pension obligations, the Group has defined an overall long-term investment strategy for the plans, with investments across a broad range of assets. The main market risks within the asset and hedging portfolio are against credit risk, interest rates, long-term inflation, equities, property, currency and bank counterparty risk. The plan liabilities are a series of future cash flows with relatively long duration. On an IAS 19 basis, these cash flows are sensitive to changes in the expected long-term inflation rate and the discount rate (AA corporate bond yield curve) where an increase in long- term inflation corresponds with an increase in the liabilities, and an increase in the discount rate corresponds with a decrease in the liabilities. The interest rate risk and credit rate risk in the US are partially hedged. The targets are based on an accounting measure of the plan liabilities. For the UK plans, there is an interest rate and inflation hedging strategy in place. The targets are based on an economic measure of the plan liabilities. Climate-related impacts, along with other environmental, social and governance (ESG) considerations, can be financially material with regard both to expected returns and to risk implications. The incorporation of such considerations into investment policy is subject to local regulations and fiduciary obligations. In the UK, the defined benefit pension schemes operated for the benefit of former Glaxo Wellcome employees and former SmithKline Beecham employees remain separate. These schemes were closed to new entrants in 2001 and subsequent UK employees are entitled to join a defined contribution scheme. In addition, the Group operates a number of post-retirement healthcare schemes, the principal one of which is in the US. The UK defined benefit plans closed to future accrual effective from 31 March 2022. As a result, post closure the accrued benefits of active participants are revalued in line with inflation (RPI for the legacy Glaxo Wellcome plans and CPI for the legacy SmithKline Beecham plans subject to the relevant caps for each arrangement) rather than capped pay increases. From 1 April 2022, former defined benefits plans employees were transferred to the defined contribution plans. All defined benefit plan participants who were still active at 1 April 2022 received a defined pension contribution of £10,000 each in 2022. The US cash balance pension plan closed to future accrual from 1 January 2021. The Group has applied the following financial assumptions in assessing the defined benefit liabilities: Rate of increase of future earnings Discount rate Expected pension increases Cash balance credit/conversion rate Inflation rate 2023 % pa n/a 4.60 2.90 n/a 2.90 2022 % pa n/a 4.80 3.10 n/a 3.10 UK 2021 % pa 2.00 2.00 3.20 n/a 3.20 2023 % pa n/a 5.00 n/a 4.00 2.50 2022 % pa n/a 5.30 n/a 3.90 2.50 US 2021 % pa n/a 2.70 n/a 2.00 2.25 2023 % pa 3.20 3.10 2.50 0.60 2.00 Rest of World 2022 % pa 3.40 3.40 2.40 0.80 2.30 2021 % pa 2.90 1.10 2.30 0.20 1.90 Sensitivity analysis detailing the effect of changes in assumptions is provided on page 227. The analysis provided reflects the assumption changes which have the most material impact on the results of the Group. 220 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued The amounts recorded in the income statement and statement of comprehensive income for the three years ended 31 December 2023 in relation to the defined benefit pension and post-retirement healthcare schemes were as follows: 2023 Amounts charged to operating profit Current service cost Past service cost Net interest cost Gains from settlements Expenses Remeasurement gains/(losses) recorded in the statement of comprehensive income 2022 Amounts charged to operating profit Current service cost Past service cost/(credit) Net interest (income)/cost Gains from settlements Expenses UK £m – 3 (5) – 14 12 28 UK £m 13 6 (11) – 14 22 Remeasurement gains/(losses) recorded in the statement of comprehensive income (1,169) 2021 Amounts charged to operating profit Current service cost Past service cost/(credit) Net interest (income)/cost Gains from settlements Expenses UK £m 53 27 3 – 15 98 US £m Rest of World £m Pensions Group £m Post-retirement benefits Group £m 5 – 35 – 16 56 45 91 – 16 (6) – 101 38 96 3 46 (6) 30 169 111 12 – 47 – (1) 58 (40) US £m Rest of World £m Pensions Group £m Post-retirement benefits Group £m 7 – 20 – 21 48 36 126 – 9 (22) – 113 261 146 6 18 (22) 35 183 22 – 32 – (1) 53 (872) 228 US £m Rest of World £m Pensions Group £m Post-retirement benefits Group £m 9 2 18 – 12 41 119 (10) 7 (2) 2 116 181 19 28 (2) 29 255 17 (3) 22 – – 36 Remeasurement gains/(losses) recorded in the statement of comprehensive income1 572 98 186 856 68 The amounts included within past service costs in the UK included £3 million (2022: £6 million; 2021: £26 million) of augmentation costs which arose from Major restructuring programmes. 221 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued A summarised balance sheet presentation of the Group defined benefit pension schemes and other post-retirement benefits is set out in the table below: Recognised in other non-current assets: Pension schemes in surplus Recognised in pensions and other post-employment benefits: Pension schemes in deficit Post-retirement benefits 2023 £m 2022 £m 2021 £m 634 229 741 (1,397) (1,585) (943) (994) (2,340) (2,579) (1,870) (1,243) (3,113) In the event of a plan wind-up, GSK believes the UK pension scheme rules provide the company with the right to a refund of surplus assets following the full settlement of plan liabilities. As a result, the net surplus in the UK defined benefit pension schemes is recognised in full. The fair values of the assets and liabilities of the UK and US defined benefit pension schemes, together with aggregated data for other defined benefit pension schemes in the Group are as follows: At 31 December 2023 Equities: Multi-asset funds Property: Corporate bonds: Government bonds: Insurance contracts Other (liabilities)/assets Fair value of assets – listed – unlisted – listed – unlisted – listed – unlisted – listed Present value of scheme obligations Net surplus/(obligation) Included in other non-current assets Included in pensions and other post-employment benefits Actual return on plan assets UK £m 1,647 – 852 – 467 2,019 – 4,897 990 (1,374) 9,498 US £m Rest of World £m 447 349 – – – 119 698 – 774 – 104 2 – – 24 205 15 527 771 89 Group £m 2,443 2 852 – 610 2,922 15 6,198 1,761 (1,181) 2,142 1,982 13,622 (9,222) (2,757) (2,406) (14,385) 276 457 (181) 276 647 (615) (424) – (615) (615) 196 177 (601) (424) 138 (763) 634 (1,397) (763) 981 The multi-asset funds comprise investments in pooled investment vehicles that are invested across a range of asset classes, increasing diversification within the growth portfolio. The value of funds in this asset class with a quoted market price is £209 million (2022: £211 million). The ‘Other (liabilities)/assets’ category comprises cash and mark to market values of derivative positions. Index-linked gilts held as part of a UK repo programme are included in government bonds. The related loan of £1,853 million at 31 December 2023 (2022: £2,376 million; 2021: £513 million) is deducted within ‘Other assets’. 222 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued At 31 December 2022 Equities: Multi-asset funds Property: Corporate bonds: – listed – unlisted – listed – unlisted – listed – unlisted Government bonds: – listed Insurance contracts Other (liabilities)/assets Fair value of assets Present value of scheme obligations Net surplus/(obligation) Included in other non-current assets Included in pensions and other post-employment benefits UK £m 1,351 – 1,101 – 464 1,692 – 4,048 1,003 (645) 9,014 US £m Rest of World £m 437 – – – 140 779 – 723 – 181 371 2 – 19 1 124 15 558 691 89 2,260 1,870 Group £m 2,159 2 1,101 19 605 2,595 15 5,329 1,694 (375) 13,144 (9,117) (3,030) (2,353) (14,500) (103) (770) (483) (1,356) — 109 (212) (103) — – (770) (770) — 120 (603) (483) — 229 (1,585) (1,356) Actual return on plan assets (4,710) (253) (550) (5,513) At 31 December 2021 Equities: Multi-asset funds Property: Corporate bonds: – listed – unlisted – listed – unlisted – listed – unlisted Government bonds: – listed Insurance contracts Other (liabilities)/assets Fair value of assets Asset ceiling restrictions Present value of scheme obligations Net surplus/(obligation) Included in Other non-current assets Included in Pensions and other post-employment benefits UK £m 3,954 – 1,415 – 502 1,503 – 5,054 1,334 (130) US £m Rest of World £m 522 – – – 154 975 – 724 – 149 731 4 – 68 1 140 15 984 917 72 Group £m 5,207 4 1,415 68 657 2,618 15 6,762 2,251 91 13,632 2,524 2,932 19,088 – – (26) (26) (13,299) (3,248) (3,644) (20,191) 333 (724) (738) (1,129) 606 (273) 333 – (724) (724) 135 (873) (738) 741 (1,870) (1,129) Actual return on plan assets 541 97 48 686 223 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued Movements in fair values of assets Assets at 1 January 2021 Exchange adjustments Interest income Expenses Settlements and curtailments Remeasurement Employer contributions Scheme participants’ contributions Benefits paid Assets at 31 December 2021 Exchange adjustments Interest income Expenses Settlements and curtailments Remeasurement Employer contributions Scheme participants’ contributions Transfer to assets held for sale/distribution Benefits paid Assets at 31 December 2022 Exchange adjustments Interest income Expenses Settlements and curtailments Remeasurement Employer contributions Scheme participants’ contributions Transfer to assets held for sale/distribution Benefits paid Assets at 31 December 2023 UK £m US £m Rest of World £m Post-retirement benefits Group £m Pensions Group £m 19,206 13,582 2,635 – 187 (15) – 354 139 3 (618) 13,632 – 271 (14) – 31 57 (12) – 40 40 – (267) 2,524 286 71 (21) – (4,981) (324) 755 – – (649) 9,014 — 430 (14) – 217 363 – – 50 – – (326) 2,260 (125) 111 (16) – 85 125 – – 2,989 (184) 18 – (7) 30 133 24 (153) 262 (27) (7) 424 312 27 (97) (982) 2,906 19,062 122 28 – (8) (578) 114 15 (624) (105) 1,870 (84) 60 — 2 78 118 11 – 408 370 (35) (8) (5,883) 919 15 (624) (1,080) 13,144 (209) 601 (30) 2 380 606 11 – (512) 9,498 (298) 2,142 (73) 1,982 (883) 13,622 – – – – – – 105 15 (120) – – – – – – 117 18 – (135) – – – – – – 98 18 – (116) – The final instalment of the cash funding or technical provision deficits of £1,080 million identified in the 31 December 2020 pension scheme valuations in three GSK UK Pension Schemes was paid in 2023. During March 2022, GSK transferred 7,004 GSK Consumer Healthcare Holdings Limited (GSKCHH) C Ordinary Shares (representing 11.03%. (in aggregate) of GSK’s interest in GSKCHH to three Scottish Limited Partnerships (“SLPs”), each providing a funding mechanism for a separate GSK UK defined benefit pension scheme. As part of the steps relating to the demerger and separation, the SLPs transferred their applicable portion of GSKCHH C Ordinary Shares to Haleon plc (“Haleon”) in consideration for shares in Haleon. At the time of demerger the SLPs together held shares representing 7.5% of the total issued share capital of Haleon. The contributions were collateralised by the creation of three Scottish Limited Partnerships (SLPs). Each of the three principal UK defined benefit pension schemes (two benefiting current and former Glaxo Welcome employees, with the third benefiting current and former SmithKline Beecham employees) had an interest in one of the SLPs at the time of demerger. Scottish Limited Partnership General Partner Limited Partners GSK (No. 1) Scottish Limited Partnership GSK GP1 Ltd GSK LP Ltd GSK (No. 2) Scottish Limited Partnership GSK GP1 Ltd GSK LP Ltd GSK (No. 3) Scottish Limited Partnership GSK GP2 Ltd GSK LP Ltd Berkeley Square Pension Trustee Company Ltd acting on behalf of the GSK Pension Scheme (ceased to be a Limited Partner effective from 28 June 2023) Berkeley Square Pension Trustee Company Ltd acting on behalf of the GSK Pension Fund (ceased to be a Limited Partner effective from 28 June 2023) SmithKline Beecham Pension Plan Trustee Ltd acting on behalf of the SmithKline Beecham Pension Plan (ceased to be a Limited Partner effective from 28 June 2023) 224 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued Each pension scheme, through its SLP interest received a distribution from that SLP with regards to the net proceeds of sales of Haleon shares and dividend income on the Haleon shares up to the amount equal to the agreed threshold (“Proceeds Threshold”). of £1,080 million increased by £7 million notional interest. Payment of this amount fully funded the cash funding or “technical provisions” deficits in the three pension schemes shown by the 31 December 2020 valuations. As at 31 December 2023, total cash contributions totalling £353 million (2022: £691 million; 2021: £44 million) were made towards the Proceeds Threshold leaving no further outstanding amount due to the UK pension schemes. The cash contributions included £17 million of distributions of dividends on Haleon shares from the SLPs to the Schemes. The GSK UK Pension Schemes exited the SLP partnership on 28 June 2023 after receipt of the Proceeds Threshold and notional interest. The remaining economic interest in the SLPs is held by GSK LP Ltd, a 100% owned subsidiary of GSK plc and the GSK- controlled General Partner of each SLP. Employer contributions for 2024, are estimated to be approximately £350 million in respect of defined benefit pension schemes and £80 million in respect of other post-retirement benefits. Movements in defined benefit obligations Obligations at 1 January 2021 Exchange adjustments Service cost Past service cost Interest cost Settlements and curtailments Remeasurement Scheme participants’ contributions Benefits paid Obligations at31 December 2021 Exchange adjustments Service cost Past service cost Interest cost Settlements and curtailments Remeasurement Scheme participants’ contributions Transfer to assets held for sale/distribution Benefits paid Obligations at 31 December 2022 Exchange adjustments Service cost Past service cost Interest cost Settlements and curtailments Remeasurement Scheme participants’ contributions Transfer to assets held for sale/distribution Benefits paid Obligations at 31 December 2023 UK £m US £m Rest of World £m Pensions Group £m Post-retirement benefits Group £m (13,858) (3,445) (4,007) (21,310) (1,363) – (56) (28) (190) – 218 (3) 618 (40) (9) (2) (76) – 57 – 267 258 (151) 25 (23) 17 164 (24) 97 218 (216) (5) (289) 17 439 (27) 982 4 (29) (12) (26) – 78 (15) 120 (13,299) (3,248) (3,644) (20,191) (1,243) – (13) (6) (260) – 3,812 – – 649 (371) (7) – (91) – 360 – – 326 (124) (126) – (37) 29 839 (15) 621 105 (495) (146) (6) (388) 29 5,011 (15) 621 1,080 (125) (22) – (32) – 228 (18) 83 135 (9,117) (3,031) (2,352) (14,500) (994) – – (3) (425) – (189) – – 512 166 (5) – (145) – (40) – – 298 87 (91) – (76) 4 (40) (11) – 73 253 (96) (3) (646) 4 (269) (11) – 883 53 (13) – (47) – (40) (18) – 116 (9,222) (2,757) (2,406) (14,385) (943) 225 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued The defined benefit pension obligation is analysed as follows: Funded Unfunded 2023 £m 2022 £m 2021 £m (13,782) (13,887) (19,419) (603) (613) (772) (14,385) (14,500) (20,191) The liability for the US post-retirement healthcare scheme has been assessed using the same assumptions as for the US pension scheme, together with the assumption for future medical inflation of 6.75% (2022: 7%) in 2023, grading down to 5% in 2031 and thereafter. At 31 December 2023, the US post-retirement healthcare scheme obligation was £785 million (2022: £870 million; 2021: £1,059 million). Post-retirement benefits are unfunded. The movement in the net defined benefit liability is as follows: At 1 January Exchange adjustments Service cost Past service cost Interest cost Settlements and curtailments Remeasurements: Return on plan assets, excluding amounts included in interest (Loss)/gain from change in demographic assumptions Gain/(loss) from change in financial assumptions Experience (loss)/gain Employer contributions Transfer to assets held for sale/distribution Expenses At 31 December The remeasurements included within post-retirement benefits are detailed below: Gain from change in demographic assumptions Gain/(loss) from change in financial assumptions Experience gains The defined benefit pension obligation analysed by membership category is as follows: Active Retired Deferred The post-retirement benefit obligation analysed by membership category is as follows: Active Retired Deferred The weighted average duration of the defined benefit obligation is as follows: Pension benefits Post-retirement benefits 2023 £m 2022 £m 2021 £m (1,356) (1,129) (2,104) 44 (96) (3) (45) 6 380 135 (137) (267) 606 – (30) (763) 2023 £m 7 (43) (4) (40) (87) (146) (6) (18) 21 (5,883) 92 5,868 (949) 919 (3) (35) 65 (216) (5) (27) 10 424 (62) 716 (215) 312 – (27) (1,356) (1,129) 2022 £m 21 219 (12) 228 2023 £m 1,508 8,730 4,147 2022 £m 1,390 8,540 4,570 14,385 14,500 2023 £m 277 666 – 943 2023 years 11 10 2022 £m 306 688 – 994 2022 years 12 10 2021 £m 19 35 24 78 2021 £m 4,196 11,115 4,880 20,191 2021 £m 494 748 1 1,243 2021 years 15 12 226 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 31. Pensions and other post-employment benefits continued Sensitivity analysis The effect of changes in assumptions used on the benefit obligations and on the 2024 annual defined benefit pension and post- retirement costs are detailed below. This information has been determined by taking into account the duration of the liabilities and the overall profile of the plan memberships. Discount rate (Decrease)/increase in annual pension cost Increase/(decrease) in annual post-retirement benefits cost (Decrease)/increase in pension obligation (Decrease)/increase in post-retirement benefits obligation (Decrease)/increase in annual pension cost Increase/(decrease) in annual post-retirement benefits cost (Decrease)/increase in pension obligation (Decrease)/increase in post-retirement benefits obligation Inflation rate Increase/(decrease) in annual pension cost Increase/(decrease) in pension obligation Increase/(decrease) in annual pension cost Increase/(decrease) in pension obligation Life expectancy Increase in annual pension cost Increase in annual post-retirement benefits cost Increase in pension obligation Increase in post-retirement benefits obligation Rate of future healthcare inflation Increase in annual post-retirement benefits cost Increase in post-retirement benefits obligation 0.25% increase £m (18) 1 (373) (20) 0.75% increase £m (58) 3 (1,071) (57) 0.25% increase £m 16 289 0.75% increase £m 46 897 1 year increase £m 20 2 432 32 1% increase £m 2 34 0.25% decrease £m 18 (1) 391 22 0.75% decrease £m 51 (3) 1,231 66 0.25% decrease £m (14) (280) 0.75% decrease £m (40) (803) 227 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 32. Other provisions At 1 January 2023 Exchange adjustments Charge for the year Reversed unused Unwinding of discount Utilised Transfer to assets held for sale/distribution Additions through business combinations Reclassifications and other movements Transfer to Pension obligations At 31 December 2023 To be settled within one year To be settled after one year At 31 December 2023 Legal and other disputes £m Major restructuring programmes £m Employee related provisions £m Other provisions £m 218 (21) 266 (4) 10 351 (13) 172 (55) – (202) (169) – – – – 267 248 19 267 – – (1) (3) 282 215 67 282 309 (9) 177 (33) – (62) – – 1 – 306 (5) 124 (143) – (88) – – 113 – Total £m 1,184 (48) 739 (235) 10 (521) – – 113 (3) 383 307 1,239 172 211 383 109 198 307 744 495 1,239 Legal and other disputes The Group is involved in a substantial number of legal and other disputes, including notification of possible claims, as set out in Note 47, ‘Legal proceedings’. Provisions for legal and other disputes include amounts relating to product liability, anti-trust, government investigations, contract terminations and self insurance. The Group may become involved in significant legal proceedings in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability, if any, that could result from ultimate resolution of the proceedings. In these cases, the Group would provide appropriate disclosures about such cases, but no provision would be made. The net charge for the year of £262 million (including reversals and estimated insurance recoveries) primarily related to provisions for product liability cases, commercial disputes and various other government investigations. The discount on the provision is £10 million in 2023 (2022: £3 million). The discount was calculated using risk-adjusted projected cash flows and risk-free rates of return. In respect of product liability claims related to certain products, provision is made when there is sufficient history of claims made and settlements to enable management to make a reliable estimate of the provision required to cover unasserted claims, and to determine the probability of the outflow of cash. The ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations. The Group’s position could change over time, and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group’s financial accounts. It is in the nature of the Group’s business that a number of these matters may be the subject of negotiation and litigation over many years. Litigation proceedings, including the various appeal procedures, often take many years to reach resolution, and out-of-court settlement discussions can also often be protracted. Indemnified disputes will result in a provision charge and a corresponding receivable. The Group is in potential settlement discussions in a number of the disputes for which amounts have been provided and, based on its current assessment of the progress of these disputes, estimates that £248 million of the amount provided at 31 December 2023 will be settled within one year. For a discussion of legal issues, see Note 47, ‘Legal proceedings’. Major restructuring programmes During 2023, the Group had two major restructuring programmes: the Separation Preparation programme which focused on preparing for the separation of GSK into two companies and is now largely complete, plus the Significant Acquisitions programme which is focused on the integration of recent acquisitions. Restructuring provisions primarily include severance costs when management has made a formal decision to eliminate certain positions and this has been communicated to the groups of employees affected and appropriate consultation procedures completed, where appropriate. No provision is made for staff severance payments that are paid immediately. The discount on the provisions increased by £0.4 million in 2023 (2022: increased by £1 million). Pension augmentation includes £3 million relating to the defined benefit plan arising from staff redundancies, as shown in Note 31, ‘Pensions and other post-employment benefits’. 228 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 32. Other provisions continued Employee related provisions Employee related provisions include obligations for certain medical benefits to disabled employees and their spouses in the US. At 31 December 2023, the provision for these benefits amounted to £48 million (2022: £66 million). Other employee benefits reflect a variety of provisions for severance costs, jubilee awards and other long-service benefits. Given the nature of these provisions, the amounts are likely to be settled over many years. Other provisions Included in other provisions are provisions for onerous contracts, insurance provisions and a number of other provisions including vehicle insurance and regulatory matters. 33. Contingent consideration liabilities The consideration for certain acquisitions includes amounts contingent on future events such as development milestones or sales performance. The Group has provided for the fair value of this contingent consideration as follows: At 1 January 2021 Remeasurement through income statement Cash payments: operating cash flows Cash payments: investing activities At 31 December 2021 Remeasurement through income statement Exchange movement through reserves Initial recognition from business combinations Cash payments: operating cash flows Cash payments: investing activities At 31 December 2022 Remeasurement through income statement Exchange movement through reserves Cash payments: operating cash flows Cash payments: investing activities At 31 December 2023 Shionogi-ViiV Healthcare £m Affinivax £m Novartis Vaccines £m 5,359 1,026 (721) (105) 5,559 1,431 – – (1,031) (69) 5,890 934 – (1,106) – 5,718 – – – – – 17 2 482 – – 501 44 (29) – – 516 477 32 (21) (9) 479 231 – – (27) (10) 673 (210) – (28) (11) 424 Other £m 33 5 – – 38 (34) – – – – 4 – – – – 4 Total £m 5,869 1,063 (742) (114) 6,076 1,645 2 482 (1,058) (79) 7,068 768 (29) (1,134) (11) 6,662 Of the contingent consideration payable at 31 December 2023, £1,053 million (2022: £1,289 million) is expected to be paid within one year. The consideration payable for the acquisition of the Shionogi-ViiV Healthcare joint venture, Affinivax and the Novartis Vaccines business are expected to be paid over a number of years. As a result, the total estimated liabilities are discounted to their present values, shown above. The Shionogi-ViiV Healthcare contingent consideration liability is discounted at 8% (2022: 8%), the Affinivax contingent consideration liability is discounted at 8.5% (2022: 9.9%) and the Novartis Vaccines contingent consideration liability is discounted at 7.5% (2022: 7.5%) for commercialised products and at 8.5% (2022: 8.5%) for pipeline assets. The Shionogi-ViiV Healthcare and Novartis Vaccines contingent consideration liabilities are calculated principally based on the forecast sales performance of specified products over the lives of those products. The Affinivax contingent consideration is based upon two potential milestone payments, each of $0.6 billion (£0.5 billion) which will be paid if certain paediatric clinical development milestones are achieved. 229 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 33. Contingent consideration liabilities continued The table below shows on an indicative basis the income statement and balance sheet sensitivity to reasonably possible changes in key inputs to the valuations of the contingent consideration liabilities. Increase/(decrease) in financial liability and loss/(gain) in income statement Shionogi-ViiV Healthcare £m Affinivax £m Novartis Vaccines £m Shionogi-ViiV Healthcare £m Affinivax £m 2023 10% increase in sales forecasts* 15% increase in sales forecasts* 10% decrease in sales forecasts* 15% decrease in sales forecasts* 1% increase in discount rate 1.5% increase in discount rate 1% decrease in discount rate 1.5% decrease in discount rate 10 cent appreciation of US Dollar 15 cent appreciation of US Dollar 10 cent depreciation of US Dollar 15 cent depreciation of US Dollar 10 cent appreciation of Euro 15 cent appreciation of Euro 10 cent depreciation of Euro 15 cent depreciation of Euro 10% increase in probability of milestone success 10% decrease in probability of milestone success 539 807 (539) (808) (174) (256) 184 281 386 604 (330) (478) 91 144 (79) (113) n/a n/a N/A N/A N/A N/A (12) (18) 13 19 44 69 (38) (54) N/A N/A N/A N/A 75 (75) 63 94 (62) (92) (26) (38) 30 47 11 17 (8) (12) 19 30 (16) (22) 21 (10) 556 834 (555) (833) (199) (292) 214 328 411 645 (347) (501) 109 171 (91) (130) N/A N/A N/A N/A N/A N/A (7) (10) 7 11 45 71 (38) (56) N/A N/A N/A N/A 82 (82) 2022 Novartis Vaccines £m 103 154 (103) (153) (55) (80) 65 101 22 36 (19) (27) 23 36 (19) (28) 20 (10) * The sales forecast is for ViiV Healthcare sales only in respect of the Shionogi-ViiV Healthcare contingent consideration. An explanation of the accounting for ViiV Healthcare is set out on page 84. 34. Other non-current liabilities Accruals Deferred income Other payables 2023 £m 4 254 849 1,107 2022 £m 11 83 805 899 Other payables includes a number of employee-related liabilities including employee savings plans. 35. Contingent liabilities At 31 December 2023, contingent liabilities where GSK has a present obligation as a result of a past event, comprising guarantees and other items arising in the normal course of business, amounted to £32 million (2022: £58 million). At 31 December 2023, £0.2 million (2022: £0.5 million) of financial assets were pledged as collateral for contingent liabilities. Provision is made for the outcome of tax, legal and other disputes where it is both probable that the Group will suffer an outflow of funds and it is possible to make a reliable estimate of that outflow. If it is not possible to meaningfully assess whether the outcomes will result in a probable outflow, or to quantify or reliably estimate the liability, if any, no provision is recorded. Descriptions of the significant legal and other disputes to which the Group is a party are set out in Note 47, ‘Legal proceedings’. 230 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 36. Commitments Contractual obligations and commitments Contracted for but not provided in the financial statements: Intangible assets Property, plant and equipment Investments Purchase commitments Pensions and post-retirement benefits Interest on loans Future finance charges on leases Lease contracts that have not yet commenced 2023 £m 2022 £m 16,329 10,659 762 153 31 – 5,446 254 5 743 138 161 345 6,322 146 395 22,980 18,909 The commitments related to intangible assets include milestone payments, which are dependent on successful clinical development or on meeting specified sales targets, and which represent the maximum that would be paid if all milestones, however unlikely, are achieved. The amounts disclosed are not risk-adjusted or discounted. The increase in intangible asset commitments in 2023 is mainly attributable to new R&D collaborations including collaborations with Wave Life Sciences USA, Inc. and Shanghai Hansoh Biomedical Co. Ltd. In 2022, GSK reached an agreement with the trustees of the UK pension schemes to make additional contributions of £1,080 million, to eliminate the pension deficit identified at the 31 December 2020 actuarial funding valuation. Prior to the Consumer Healthcare demerger, GSK agreed to collateralise this commitment and accelerate funding with additional contributions (Refer to Note 31 'Pensions and other post-employment benefits'). At 31 December 2023, £nil (2022: £345 million) additional contributions were unpaid. Included within the total commitments above is £30 million related to nature based carbon removal projects that support GSK’s net- zero and nature positive goals and £46 million related to the transition to a lower-carbon propellant. The table excludes any amounts already capitalised in the Financial Statements for the year end 2023. 231 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 37. Share capital and share premium account Share Consolidation Following completion of the Consumer Healthcare business demerger on 18 July 2022, GSK plc Ordinary shares were consolidated to maintain share price comparability before and after demerger. The consolidation was approved by GSK shareholders at a General Meeting held on 6 July 2022. Shareholders received 4 new Ordinary shares with a nominal value of 31¼ pence each for every 5 existing Ordinary shares which had a nominal value of 25 pence each. Earnings per share, diluted earnings per share, adjusted earnings per share and dividends per share were retrospectively adjusted to reflect the Share Consolidation in all the periods presented in years 2021 and 2022. Share capital issued and fully paid: At 1 January 2021 Issued under employee share schemes Ordinary shares acquired by ESOP Trusts At 31 December 2021 Impact of share consolidation Issued under employee share schemes Ordinary shares acquired by ESOP Trusts At 31 December 2022 Issued under employee share schemes Ordinary shares acquired by ESOP Trusts At 31 December 2023 Ordinary shares of 25p each pre-share consolidation Ordinary shares of 31¼p each post-share consolidation Share premium Number £m £m 5,385,189,617 1,346 3,281 1,825,442 – 1 – 20 – 5,387,015,059 1,347 3,301 (1,077,403,011) 1,731,293 – – – – – 25 114 4,311,343,341 1,347 3,440 802,642 – 1 – 9 2 4,312,145,983 1,348 3,451 At 31 December 2023, of the issued share capital, 58,817,197 shares were held in the ESOP Trusts, out of which 58,493,518 shares were held for the future exercise of share options and share awards and 323,679 shares were held for the Executive Supplemental Savings plan. 197,068,169 shares were held as Treasury shares and 4,056,260,617 shares were in free issue. All issued shares are fully paid and there are no shares authorised but not in issue. The nominal, carrying and market values of the shares held in the ESOP Trusts are disclosed in Note 45, ‘Employee share schemes’. 38. Movements in equity Retained earnings and other reserves amounted to £8,548 million at 31 December 2023 (2022: £5,811 million; 2021: £10,407 million) of which £451 million (2022: £463 million; 2021: £476 million) related to associates and joint ventures. The cumulative translation exchange in equity is as follows: Net translation exchange included in: Non- controlling interests £m Fair value reserve £m Retained earnings £m At 1 January 2021 Exchange movements on overseas net assets and net investment hedges Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates At 31 December 2021 Exchange movements on overseas net assets and net investment hedges Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates Movement attributable to continuing operations Movement attributable to discontinued operations1 At 31 December 2022 Exchange movements on overseas net assets and net investment hedges Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates At 31 December 2023 (539) (239) (25) (803) 109 2 (692) 263 (429) (41) (34) (504) (9) – – (9) 4 – (5) – (5) 19 – 14 (161) (20) – (181) (28) – (209) 112 (97) (25) – (122) Total translation exchange £m (709) (259) (25) (993) 85 2 (906) 375 (531) (47) (34) (612) (1) Includes £554 million reclassification to the consolidated income statement of net exchange gains related to the demerger of the Consumer Healthcare business. 232 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 38. Movements in equity continued The analysis of other comprehensive income by equity category is as follows: 2023 Items that may be subsequently reclassified to income statement: Retained earnings £m Other reserves £m Non- controlling interests £m Exchange movements on overseas net assets and net investment hedges (41) 19 Reclassification of exchange movements on liquidation or disposal of subsidiaries and associates Fair value movements on cash flow hedges Tax on fair value movements on cash flow hedges Reclassification of cash flow hedges to income Items that will not be reclassified to income statement: Exchange movements on overseas net assets of non-controlling interests Fair value movements on equity investments Tax on fair value movements on equity investments Remeasurement on defined benefit plans Tax on remeasurement defined benefit plans Fair value movements on cash flow hedges Total other comprehensive (expense)/income for the year 2022 Items that may be subsequently reclassified to income statement: Exchange movements on overseas net assets and net investment hedges Reclassification of exchange movements on liquidation or disposal of subsidiaries and associates Fair value movements on cash flow hedges Tax on fair value movements on cash flow hedges Reclassification of cash flow hedges to income Items that will not be reclassified to income statement: Exchange movements on overseas net assets of non-controlling interests Fair value movements on equity investments Tax on fair value movements on equity investments Remeasurement on defined benefit plans Tax on remeasurement defined benefit plans Fair value movements on cash flow hedges Other comprehensive (expense)/income for the year from continuing operations Other comprehensive (expense)/income for the year from discontinued operations Total other comprehensive (expense)/income for the year 2021 Items that may be subsequently reclassified to income statement: Exchange movements on overseas net assets and net investment hedges Reclassification of exchange movements on liquidation or disposal of subsidiaries and associates Fair value movements on cash flow hedges Tax on fair value movements on cash flow hedges Reclassification of cash flow hedges to income statement Items that will not be reclassified to income statement: Exchange movements on overseas net assets of non-controlling interests Fair value movements on equity investments Tax on fair value movements on equity investments Remeasurement losses on defined benefit plans Tax on remeasurement defined benefit plans Other comprehensive (expense)/income for the year Total £m (22) (34) (1) 1 4 (25) (244) 14 71 (41) (40) (317) Total £m 113 2 (18) 9 14 (28) (754) 56 (786) 211 (6) – – – – – (25) – – – – – (25) – – – – – (28) – – – – – Retained earnings £m Other reserves £m Non- controlling interests £m (34) – – – – – – 71 (41) – (45) – (1) 1 4 – (244) 14 – – (40) (247) 109 2 – – – – – – (786) 211 – (464) 375 (89) 4 – (18) 9 14 – (754) 56 – – (6) (695) (19) (714) (28) (1,187) – (28) 356 (831) Retained earnings £m Other reserves £m Non- controlling interests £m (239) (25) – – – – – – 941 (223) 454 – – 5 (8) 12 – (911) 131 – – – – – – – (20) – – – – (771) (20) Total £m (239) (25) 5 (8) 12 (20) (911) 131 941 (223) (337) 233 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 38. Movements in equity continued Information on net investment hedges is provided in part (d) of Note 44 ‘Financial instruments and related disclosures'. The analysis of other reserves is as follows: ESOP Trust shares £m Fair value reserve £m Cash flow hedge reserve £m Other reserves £m At 1 January 2021 Exchange adjustments Transferred to income and expenses in the year on impairments of equity investments Transferred to retained earnings in the year on disposal of equity investments Net fair value movement in the year At 31 December 2021 Exchange adjustments Transferred to retained earnings in the year on disposal of equity investments Balances derecognised on demerger Net fair value movement in the year Ordinary shares acquired by ESOP Trusts Write-down of shares held by ESOP Trusts At 31 December 2022 Exchange adjustments Transferred to retained earnings in the year on disposal of equity investments Reclassification of cash flow hedges to income statement Hedging gain/(loss) transferred to non-financial assets Net fair value movement in the year (including tax) Ordinary shares acquired by ESOP Trusts Write-down of shares held by ESOP Trusts At 31 December 2023 1,302 (31) 2,129 – – – 10 – – – – (21) 2,129 2,463 – – (139) (780) 383 28 (21) – (698) – – (5) 33 – – 12 17 (169) 141 – – (20) (2) – 4 36 – – – – – – 2,129 – – – – – – – (230) (40) – – – – (510) (22) 2,129 Total £m 3,205 (1) 168 (139) (770) 4 (4) (169) (557) (1,200) 911 1,448 19 33 4 36 (270) (285) 324 1,309 (195) (1) 168 – – (28) (36) – – – (1,200) 911 26 – – – – (285) 324 (288) (353) (308) Other reserves include various non-distributable merger and pre-merger reserves amounting to £1,849 million at 31 December 2023 (2022: £1,849 million; 2021: £1,849 million). Other reserves also include the capital redemption reserve created as a result of the share buy-back programme amounting to £280 million at 31 December 2023 (2022: £280 million; 2021: £280 million). 39. Non-controlling interests Total non-controlling interests includes the following individually material non-controlling interests. Other non-controlling interests are individually not material. ViiV Healthcare GSK holds 78.3% of the ViiV Healthcare sub-group, giving rise to a material non-controlling interest. Summarised financial information available at the latest practicable date in respect of the ViiV Healthcare sub-group is as follows: Turnover Profit after taxation Other comprehensive income/(expense) Total comprehensive income Non-current assets Current assets Total assets Current liabilities Non-current liabilities Total liabilities Net liabilities 2023 £m 6,308 2,034 (19) 2,015 2023 £m 2,528 3,330 5,858 2022 £m 5,619 1,528 94 1,622 2022 £m 2,716 3,354 6,070 (3,881) (8,453) (3,762) (8,983) (12,334) (12,745) (6,476) (6,675) 2021 £m 4,637 1,087 (17) 1,070 234 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 39. Non-controlling interests continued Net cash inflow from operating activities Net cash outflow from investing activities Net cash outflow from financing activities Increase/(decrease) in cash and bank overdrafts in the year 2023 £m 2,192 2022 £m 3,442 (2) (174) 2021 £m 2,128 (287) (2,463) (2,718) (1,608) (273) 550 233 The above financial information relates to the ViiV Healthcare group on a stand-alone basis, before the impact of Group-related adjustments, primarily related to the recognition of preferential dividends. The profit after taxation of £2,034 million (2022: £1,528 million; 2021: £1,087 million) is stated after charging preferential dividends payable to GSK and Pfizer and after a charge of £858 million (2022: £1,483 million; 2021: £1,218 million) for remeasurement of contingent consideration payable. This consideration is expected to be paid over a number of years. The following amounts attributable to the ViiV Healthcare group are included in GSK’s financial statements: Share of profit for the year attributable to non-controlling interest Dividends paid to non-controlling interest Non-controlling interest in the consolidated balance sheet 40. Related party transactions 2023 £m 373 398 2022 £m 415 480 2021 £m 196 224 (648) (611) (570) At 31 December 2023, a loan of £0.8 million (2022: £nil) to Index Ventures and a loan of £0.6 million (2022: £nil ) to Medicxi Ventures I LP remained due to GSK. Cash distributions were received from investment in Medicxi Ventures I LP of £10.7 million (2022: Medicxi Ventures I LP of £6 million). In December 2023, Qura Therapeutics LLC was liquidated, the investment and the associated commitment for future contributions were de-recognised from the balance sheet. An immaterial gain (less than £1 million) was recognised. The Group had no other significant related party transactions which might reasonably be expected to influence decisions made by the users of these Financial Statements. The aggregate compensation of the Directors and GLT is given in Note 9, ‘Employee costs’. 235 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 41. Acquisitions and disposals Details of the acquisition and disposal of significant subsidiaries, associates, joint ventures and other businesses are given below: 2023 Business acquisitions On 28 June 2023, GSK completed the acquisition of BELLUS Health Inc. ("Bellus") which was effected through a Plan of Arrangement (the “Arrangement”) pursuant to the Canada Business Corporations Act. The Arrangement was approved by Bellus’ shareholders on 16 June 2023. Upon completion, GSK acquired all outstanding common shares of Bellus for US$14.75 per common share in cash, representing a total equity value of US$2 billion (£1.6 billion). The acquisition provides GSK access to camlipixant, a potential best-in-class and highly selective P2X3 antagonist currently in phase III development for the first-line treatment of adult patients with refractory chronic cough (RCC). Net assets acquired: Intangible assets Non-current equity investments Right of use assets Trade and other receivables Investments held as current assets Cash and cash equivalents Lease liabilities Trade and other payables Deferred tax liabilities Non-controlling interest Goodwill Total consideration Total £m 1,438 2 1 96 51 148 (1) (103) (136) 1,496 – 109 1,605 In 2023, the provisional values of the identifiable assets and liabilities acquired in the Affinivax, Inc. business combination were updated for the finalisation of the fair value of intangible assets, resulting in an increase in intellectual property of £39 million, a decrease to goodwill of £31 million and a decrease to deferred tax of £8 million. The amounts recognised at 31 December 2022 have not been restated on the basis of materiality. Business disposals GSK completed no material business disposals in 2023. Associates and joint ventures GSK completed no material investments or disposals of associates or joint ventures during the year. Cash flows Cash consideration (paid)/ received Net deferred consideration paid Transaction costs Cash and cash equivalents acquired/(divested) Cash (outflow)/inflow Business Acquisitions £m Business Disposals £m (1,605) – (17) 148 (1,474) 68 (19) – – 49 236 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 41. Acquisitions and disposals continued 2022 Business acquisitions On 1 July 2022, GSK completed the acquisition of 100% of Sierra Oncology, Inc., a California-based, late-stage biopharmaceutical company focused on targeted therapies for the treatment of rare forms of cancer, for $1.9 billion (£1.6 billion). The main asset is momelotinib which targets the medical needs of myelofibrosis patients with anaemia. Total transaction costs were £52 million. On 15 August 2022, GSK completed the acquisition of 100% of Affinivax, Inc. a clinical-stage biopharmaceutical company based in Cambridge, Boston, Massachusetts focused on pneumococcal vaccine candidates. The consideration for the acquisition comprised an upfront payment of $2.2 billion (£1.8 billion) as adjusted for working capital acquired paid upon closing and two potential milestone payments each of $0.6 billion (£0.5 billion) to be paid upon the achievement of certain paediatric clinical development milestones. The estimated fair value of the contingent consideration payable was £482 million. The values were provisional and were subject to change. The total transaction costs were £71 million. During 2022, no sales arising from the Sierra Oncology or Affinivax businesses were included in Group turnover and no revenue is expected until regulatory approval is received on the acquired assets. GSK continues to support the ongoing development of the acquired assets and consequently these assets will be loss making until regulatory approval on these assets is received. The development of these assets has been integrated into the Group’s existing R&D activities, so it was impracticable to quantify these development costs or the impact on Total profit after taxation for the period ended 31 December 2022. Goodwill of £1,127 million (£162 million for Sierra Oncology and £965 million for Affinivax), which is not expected to be deductible for tax purposes, has been recognised. The goodwill represents workforce in place, and specific synergies available to GSK from the business combinations. The goodwill has been allocated to the Group’s Commercial Operations and R&D segments (refer to Note 19 ‘Goodwill’ for allocation methodology). Net assets acquired Intangible assets Property, plant and equipment Right of use assets Inventory Trade and other receivables Cash and cash equivalents Lease liabilities Trade and other payables Taxation Goodwill Total Total cash Fair value of contingent consideration Sierra Oncology £m Affinivax £m Total £m 1,497 1,467 2,964 – 1 60 2 175 (1) (40) (259) 1,435 162 1,597 1,597 – 30 52 – 17 109 (55) (77) (236) 1,307 965 2,272 1,790 482 30 53 60 19 284 (56) (117) (495) 2,742 1,127 3,869 3,387 482 On 24 November 2022 GSK signed an agreement to buy out the 25% non-controlling interest in Glaxo Saudi Arabia Ltd for SAR94 million (£21 million), paid in 2023. 237 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 41. Acquisitions and disposals continued Demerger of Consumer Healthcare business On 18 July 2022, GSK plc separated its Consumer Healthcare business from the GSK Group to form Haleon, an independent listed company. The separation was effected by way of a demerger of 80.1% of GSK’s 68% holding in the Consumer Healthcare business to GSK shareholders. Following the demerger, 54.5% of Haleon was held in aggregate by GSK shareholders, 6.0% was held by GSK (including shares received by GSK’s consolidated ESOP trusts) and 7.5% was held by certain Scottish Limited Partnerships (SLPs) set up to provide collateral for a funding mechanism pursuant to which GSK will provide additional funding for GSK’s UK defined benefit pension schemes (Note 31, 'Pensions and other post-employment benefits'). The aggregate ownership by GSK (including ownership by the ESOP trusts and SLPs) after the demerger of 13.5% was measured at fair value with changes through profit or loss. In 2022, Pfizer held 32% of Haleon after the demerger. Under IFRIC 17 ‘Distributions of Non-cash Assets to Owners’ a liability and an equity distribution are measured at the fair value of the assets to be distributed when the dividend is appropriately authorised and it is no longer at the entity’s discretion. The liability and equity movement, and associated gain on distribution were recognised in Q3 2022 when the demerger distribution was authorised and occurred. The asset distributed was the 54.5% ownership of the Consumer Healthcare business. The net carrying value of the Consumer Healthcare business in the consolidated financial statements, including the retained 13.5% and net of the amount attributable to the non-controlling interest, was approximately £11 billion at the end of June. GSK’s £6.3 billion share of the shareholder loans made in Q1 2022 in advance of the pre-separation dividends was eliminated in the consolidated financial statements. The assets distributed were reduced by Consumer Healthcare transactions up to 18 July that principally included pre-separation dividends declared and settled after the end of Q2 2022 and before 18 July 2022. Those dividends included: £10.4 billion (£7.1 billion attributable to GSK) of dividends funded by Consumer Healthcare debt that was partially on-lent during Q1 2022 and dividends of £0.6 billion (£0.4 billion attributable to GSK) from available cash balances. The fair value of the 54.5% ownership of the Consumer Healthcare business distributed was £15.5 billion. This was measured by reference to the quoted average Haleon share price over the first five days of trading, this being a fair value measured with observable inputs which was considered to be representative of the fair value at the distribution date. A gain on distribution of this fair value less book value of the attributable net assets of the Consumer Healthcare business of £7.7 billion was recorded in the income statement in 2022. There was an additional gain of £2.4 billion to remeasure the retained 13.5% from its book value to fair value of £3.9 billion using the same fair value methodology as used for the distributed shares. The gain on distribution and on remeasurement of the retained stake upon demerger was presented as part of discontinued operations. Any future gains or losses on the retained stake in Haleon will be recognised in continuing operations. In addition, there was a reclassification of the Group’s share of cumulative exchange differences arising on translation of the foreign currency net assets of the divested subsidiaries and offsetting net investment hedges from reserves into the income statement of £0.6 billion. The total gain on demerger of Consumer Healthcare was £10.1 billion. These transactions were presented in profit from discontinued operations in 2022. Fair value of the Consumer Healthcare business distributed (54.5%) Fair value of the retained ownership in Haleon plc (13.5%) Total fair value Carrying amount of the net assets and liabilities distributed/de-recognised Carrying amount of the non-controlling interest de-recognised Gain on demerger before exchange movements and transaction costs Reclassification of exchange movements and net investment hedge movements on disposal of overseas subsidiaries Total gain on the demerger of Consumer Healthcare 2022 £m 15,526 3,853 19,379 (12,887) 3,038 9,530 554 10,084 Consumer Healthcare was presented as a discontinued operation as at 30 June 2022 and disclosed as such in the interim financial statements. The Consolidated Income Statement and Consolidated Cash Flow Statement distinguish discontinued operations from continuing operations. Comparative figures have been restated on a consistent basis. Financial information relating to the operations of Consumer Healthcare for the period is set out on the following page and includes financial information until 18 July 2022. This financial information differs both in purpose and basis of preparation from the Historical Financial Information and the Interim Financial Information included in the Haleon prospectus and from that which was published by Haleon on 2 March 2023. As a result, whilst the two sets of financial information are similar, they are not the same because of certain differences in accounting and disclosure under IFRS. 238 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 41. Acquisitions and disposals continued Total results Turnover Expense Profit before tax Taxation Tax rate % (Loss)/profit after taxation from discontinued operations: Consumer Healthcare Other gains/(losses) on demerger Remeasurement of discontinued operations distributed to shareholders on demerger Profit after taxation on demerger of discontinued operations Non-controlling interest in discontinued operations Earnings attributable to shareholders from discontinued operations Earnings per share from discontinued operations Other business disposals There were no other material business disposals in 2022. Cash flows Cash consideration Net deferred consideration paid Cash and cash equivalents (divested)/acquired Transaction costs paid Cash (outflow)/inflow 2022 £m 5,581 2021 £m 9,418 (4,730) (7,575) 851 (235) 27.6% 616 2,433 7,651 10,700 205 10,495 260.6p 1,843 (263) 14.3% 1,580 – – 1,580 511 1,069 26.7p Business acquisitions £m Business disposals - demerger £m Business disposals - other £m (3,392) – 284 (3,108) (79) – – (933) (933) (141) (3,187) (1,074) – (34) (9) (43) – (43) Cash consideration for business acquisitions included £5 million related to other business acquisition activity. 2021 Business acquisitions GSK completed no material business acquisitions in 2021. Business disposals GSK made a number of business disposals for net cash consideration received in the year of £10 million. The profit on the disposal of the businesses in the year of £24 million was calculated as follows: Consideration: Cash consideration including currency forwards, purchase adjustments and deferred consideration Total Net assets sold: Property, plant and equipment Cash and cash equivalents Other net assets Total Costs: Deal costs Reclassification of exchange from other comprehensive income Gain on disposals in 2021 Total £m 10 10 3 1 1 5 (16) 35 24 239 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 41. Acquisitions and disposals continued Associates and joint ventures On 20 May 2021 GSK agreed with Innoviva, Inc. (“Innoviva”) to sell all of its approximately 32 million shares of common stock of Innoviva back to Innoviva at a price of $12.25 per share, raising gross proceeds of approximately $392 million. Following settlement of the transaction, GSK will no longer hold any Innoviva stock. See details in Note 21 ‘Investment in associates and joint ventures’. Cash flows Cash consideration received Net deferred consideration paid Transaction costs Cash and cash equivalents (divested)/acquired Cash (outflow)/inflow . 42. Adjustments reconciling Total profit after tax to operating cash flows Associates and joint ventures disposals £m Business disposals £m 43 (51) (8) (1) (17) 277 – – – 277 Total profit after tax from continuing operations Tax on profits Share of after-tax (profits)/losses of associates and joint ventures Finance expense net of finance income Depreciation Amortisation of intangible assets Impairment and assets written off Profit on sale of businesses Profit on sale of intangible assets (Profit)/loss on sale of investments in associates Profit on sale of equity investments Changes in working capital: Decrease/(increase) in inventories (Increase) in trade receivables Increase/(decrease) in trade payables (Increase)/decrease in other receivables Contingent consideration paid (see Note 33) Other non-cash increase in contingent consideration liabilities Increase/(decrease) in other payables Decrease in pension and other provisions Share-based incentive plans Fair value adjustments Other Operating cash flow from continuing operations Operating cash flow from discontinued operations 2023 £m 5,308 756 5 677 1,082 1,212 467 – (12) (1) – (424) (794) (15) 145 2022 £m 4,921 707 2 803 1,061 1,086 481 (36) (185) – (1) (269) (158) 494 (458) (1,134) (1,058) 492 689 (457) 307 (107) (100) 8,096 – 1,628 (5) (962) 346 (283) (170) 7,944 932 2021 £m 3,516 83 (33) 755 1,034 1,088 529 (47) (539) 36 (8) 51 (780) 229 (382) (742) 1,063 1,505 (299) 343 (31) (122) 7,249 1,994 Total cash generated from operations 8,096 8,876 9,243 240 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 43. Reconciliation of net cash flow to movement in net debt Net debt, at beginning of year, as adjusted Decrease in cash and bank overdrafts Decrease in liquid investments Issue of long-term loans Repayment of short-term notes Repayment of/(increase in) other short-term loans Repayment of long-term loans Repayment of lease liabilities Investments/(debt) of subsidiary undertakings acquired Exchange adjustments Other non-cash movements Decrease/(increase) in net debt from continuing operations Decrease/(increase) in net debt from discontinued operations 2023 £m 2022 £m 2021 £m (17,197) (19,838) (20,780) (468) (7,597) (2,504) (72) (223) 2,116 333 144 197 50 554 (474) 2,157 (1) (1,025) 5,074 (1,021) 1,594 202 (24) (1,531) (207) (4,536) – 7,177 (18) – 2,304 (301) – 181 – 314 (134) (158) 1,100 Total net debt at end of year (15,040) (17,197) (19,838) At 1 January 2023 £m Exchange £m Other £m Interest expense £m Change in fair value £m Reclass- ifications £m Cash flow £m At 31 December 2023 £m Analysis of changes in net debt Liquid investments Cash and cash equivalents Overdrafts Debt due within one year: Commercial paper European/US MTN & Bank facilities Lease liabilities Other Debt due after one year: European/US MTN & Bank facilities Lease liabilities Net debt Interest payable Derivative financial instruments Total liabilities from financing activities* 67 – 3,723 (298) 3,425 (1,191) (2,146) (167) (150) (3,654) (16,194) (841) (17,035) (4) – (105) 6 (99) 56 48 12 21 137 469 42 511 51 – – – – – – (3) 3 – – (447) (447) – – – – – – – – – – (19) – (19) (17,197) 545 (396) (19) – – – – – – – – – – – – – – – (207) 8 1 – (29) (693) – – 343 (20,888) 649 (476) (712) 343 * Excluding cash and cash equivalents, overdrafts and liquid investments. – – – – – – (1,669) (195) – (72) – (682) 214 42 – 2,936 (78) (468) 2,858 320 2,116 197 13 (815) (1,651) (156) (113) (1,864) 2,646 (2,735) 1,669 195 1,864 – – – – (79) (14,154) – (1,051) (79) (15,205) 2,027 (15,040) 766 (335) (162) 16 2,998 (18,086) 241 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 43. Reconciliation of net cash flow to movement in net debt continued At 1 January 2022 £m Exchange £m Other £m Interest expense £m Change in fair value £m Reclass- ifications £m Demerger £m Cash flow £m At 31 December 2022 £m (1) 67 7,496 (7,734) – 137 3,723 (298) 7,496 (7,597) 3,425 (7,496) 7,052 – – – – – – – (545) 3,425 (909) 5,050 201 (87) (1,191) (2,146) (167) (150) 4,255 (3,654) – – – – – – (4,426) (186) – (4,612) (3) (4,615) 1,559 1,559 (1,466) – 2,789 (3,654) 4,426 – 569 – (16,194) (841) 569 (17,035) – – – – – – – – – – – – – – – – – Analysis of changes in net debt Liquid investments Cash and cash equivalents Overdrafts Liquid investments attributed to continuing operations Liquid investments attributed to discontinued operations Debt due within one year: Commercial paper European/US MTN & Bank facilities Lease liabilities Other Debt due within one year attributed to continuing operations Debt due within one year attributed to discontinued operations Debt due after one year: 61 3,861 (450) 3,411 407 3,818 7 99 15 114 37 151 (252) (2,596) (173) (52) (30) (174) (14) (2) (3,073) (220) (72) (3) (3,145) (223) – 1 – 1 – 1 – – 5 (9) (4) (15) (19) – – – – – – – – – – – – European/US MTN & Bank facilities (19,760) (1,386) – Lease liabilities (725) (59) (243) (43) – Debt due after one year attributed to continuing operations Debt due after one year attributed to discontinued operations Net debt Interest payable Derivative financial instruments Total liabilities from financing activities* (20,485) (1,445) (243) (43) (87) (777) (6) (20,572) (2,222) (249) (4) (47) (19,838) (2,287) (267) (47) (244) (22) (5) – (33) (865) – – 48 48 48 – 670 (23,983) (2,450) (301) (912) 718 186 4,612 3 4,615 – – – – * Excluding cash and cash equivalents, overdrafts and liquid investments. For further information on significant changes in net debt see Note 30, ‘Net debt’. 10,059 10,059 (9,236) – (8,667) (17,035) 11,618 (6,424) (17,197) 92 – 848 (640) (207) 8 11,710 (5,670) (20,888) 242 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures The objective of GSK’s Treasury activities is to minimise the net cost of financial operations and reduce its volatility to benefit earnings and cash flows. GSK uses a variety of financial instruments to finance its operations and derivative financial instruments to manage market risks from these operations. Derivatives principally comprise foreign exchange forward contracts and swaps which are used to swap borrowings and liquid assets into currencies required for Group purposes as well as interest rate swaps which are used to manage exposure to financial risks from changes in interest rates. These financial instruments reduce the uncertainty of foreign currency transactions and interest payments. Derivatives are used exclusively for hedging purposes in relation to underlying business activities and not as trading or speculative instruments. Capital management GSK’s financial strategy supports the Group’s strategic priorities and is regularly reviewed by the Board. GSK manages the capital structure of the Group through an appropriate mix of debt and equity. The capital structure of the Group consists of net debt of £15 billion (see Note 30, ‘Net debt’) and total equity, including items related to non-controlling interests, of £13 billion (see ‘Consolidated statement of changes in equity’ on page 182). Total capital, including that provided by non-controlling interests, is £28 billion. The Group continues to manage its financial policies to a credit profile that particularly targets ratings of at least A2/A (Moody's/S&P), through the cycle. The Group’s long-term credit rating with Standard & Poor’s is A (stable outlook) and with Moody’s Investor Services (‘Moody’s’) is A2 (stable outlook). The Group’s short-term credit ratings are A-1 and P-1 with Standard & Poor’s and Moody’s respectively. Liquidity risk management GSK’s policy is to borrow centrally in order to meet anticipated funding requirements. The strategy is to diversify liquidity sources using a range of facilities and to maintain broad access to financial markets. Each day, GSK sweeps cash to or from a number of global subsidiaries and central Treasury accounts for liquidity management purposes. GSK utilises both physical and notional cash pool arrangements as appropriate by location and currency. For notional cash pools, liquidity is drawn against foreign currency balances to provide both local funding and central liquidity as required and with balances actively managed and maintained to appropriate levels. As balances in notional pooling arrangements are not settled across currencies, gross cash and overdraft balances are reported. At 31 December 2023, GSK had £2.8 billion of borrowings repayable within one year and held £3.0 billion of cash and cash equivalents and liquid investments of which £2.2 billion was held centrally. GSK has access to short-term finance under a $10 billion (£7.8 billion) US commercial paper programme; $850 million (£667 million) was in issue at 31 December 2023 (2022: $900 million (£748 million)). GSK has access to short-term finance under a £5 billion Euro commercial paper programme; €170 million (£148 million) was in issue at 31 December 2023 (2022: €500 million (£443 million)). GSK has a £1.6 billion three- year and a $2.2 billion (£1.7 billion) 364 day committed facility. These committed facilities were undrawn at 31 December 2023. GSK considers this level of committed facilities to be adequate, given current liquidity requirements. GSK has a £20 billion Euro Medium Term Note programme and at 31 December 2023, £9.2 billion of notes were in issue under this programme. The Group also had $8.4 billion (£6.6 billion) of notes in issue at 31 December 2023 under a US shelf registration. GSK’s borrowings mature at dates between 2024 and 2045. The put option owned by Pfizer in ViiV Healthcare is exercisable. In reviewing liquidity requirements GSK considers that sufficient financing options are available should the put option be exercised. Market risk Interest rate risk management GSK’s objective is to minimise the effective net interest cost and to balance the mix of debt at fixed and floating rates over time. The Group’s main interest rate risk arises from borrowings and investments with floating rates and refinancing of maturing fixed rate debt where any changes in interest rates will affect future cash flows or the fair values of financial instruments. The policy on interest rate risk management limits the net amount of floating rate debt to a specific cap, reviewed and agreed no less than annually by the Board. The majority of debt is issued at fixed interest rates and changes in the floating rates of interest do not significantly affect the Group’s net interest charge. Short-term borrowings including bank facilities are exposed to the risk of future changes in market interest rates as are the majority of cash and liquid investments. Foreign exchange risk management The Group’s objective is to minimise the exposure of overseas operating subsidiaries to transaction risk by matching local currency income with local currency costs where possible. Foreign currency transaction exposures arising on external and internal trade flows are selectively hedged. GSK’s internal trading transactions are matched centrally and inter-company payment terms are managed to reduce foreign currency risk. Where possible, GSK manages the cash surpluses or borrowing requirements of subsidiary companies centrally using forward contracts to hedge future repayments back into the originating currency. In order to reduce foreign currency translation exposure, the Group seeks to denominate borrowings in the currencies of our principal assets and cash flows. These are primarily denominated in US Dollars, Euros and Sterling. Borrowings can be swapped into other currencies as required. 243 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Borrowings denominated in, or swapped into, foreign currencies that match investments in overseas Group assets may be treated as a hedge against the relevant assets. Forward contracts in major currencies are also used to reduce exposure to the Group’s investment in overseas assets (see ‘Net investment hedges’ section of this note for further details). Credit risk Credit risk is the risk that a counterparty will default on its contractual obligations resulting in financial loss to the Group and arises on cash and cash equivalents and favourable derivative financial instruments held with banks and financial institutions as well as credit exposures to wholesale and retail customers, including outstanding receivables. The Group considers its maximum credit risk at 31 December 2023 to be £9,528 million (31 December 2022: £10,180 million) which is the total of the Group’s financial assets with the exception of ’Other investments’ (comprising equity investments) which bear equity risk rather than credit risk. See page 247 for details on the Group’s total financial assets. At 31 December 2023, GSK’s greatest concentration of credit risk was £1.2 billion with a wholesaler in the US (2022: £1.1 billion with a wholesaler in the US). See page 245 for further information on the Group’s credit risk exposure in respect of the three largest US wholesaler customers. There has been no change in the estimation techniques or significant assumptions made during the current reporting period in assessing the loss allowance for financial assets at amortised cost or at FVTOCI since the adoption of IFRS 9 at the start of the 2018 reporting period. Treasury-related credit risk GSK sets global counterparty limits for each of GSK’s banking and investment counterparties based on long-term credit ratings from Moody’s and Standard & Poor’s. Usage of these limits is actively monitored. GSK actively manages its exposure to credit risk, reducing surplus cash balances wherever possible. This is part of GSK’s strategy to regionalise cash management and to concentrate cash centrally as much as possible. The table below sets out the credit exposure to counterparties by rating for liquid investments, cash and cash equivalents and derivatives. The gross asset position on each derivative contract is considered for the purpose of this table, although, under ISDA agreements, the amount at risk is the net position with each counterparty. Table (e) on page 255 sets out the Group’s financial assets and liabilities on an offset basis. 244 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued At 31 December 2023, £44 million (2022: £60 million) of cash is categorised as held with unrated or sub-investment grade rated counterparties (lower than BBB-/Baa3). This exposure is concentrated in overseas banks used for local cash management or investment purposes, including: £18 million in Saudi Arabia with Saudi British Bank; £15 million with Halk Bank in the UK; £7 million in Nigeria held with United Bank for Africa, Zenith Bank, Access Bank and Stanbic IBTC Bank; £2 million in Brazil held with Banco Bradesco, Itau UniBanco, Banco Do Brasil and Caixa Economica Federal; and £1 million with Banco De La Produccion in Ecuador. Of the £55 million of bank balances and deposits held with BBB/Baa rated counterparties, £3.4 million was held with BBB-/Baa3 rated counterparties, including balances or deposits of £2.6 million with State Bank of India in India. These banks are used for local investment purposes. GSK measures expected credit losses over cash and cash equivalents as a function of individual counterparty credit ratings and associated 12 month default rates. Expected credit losses over cash and cash equivalents and third-party financial derivatives are deemed to be immaterial and no such loss has been experienced during 2023. Credit ratings are assigned by Standard & Poor’s and Moody’s respectively. Where the opinions of the two rating agencies differ, GSK assigns the lower rating of the two to the counterparty. Where local rating agency or Fitch data is the only source available, the ratings are converted to global ratings equivalent to those of Standard & Poor’s or Moody’s using published conversion tables. These credit ratings form the basis of the assessment of the expected credit loss on Treasury-related balances held at amortised cost being bank balances and deposits and Government securities. 2023 Bank balances and deposits US Treasury and Treasury repo only money market funds Liquidity funds Government securities Third party financial derivatives Total 2022 Bank balances and deposits US Treasury and Treasury repo only money market funds Liquidity funds Government securities Third party financial derivatives Total AAA/Aaa £m AA/Aa £m – 155 839 – – 994 28 – – 42 – 70 AAA/Aaa £m AA/Aa £m – 146 2,253 – – 2,399 – – – 67 – 67 A/A £m 1,815 – – – 130 1,945 A/A £m 1,215 – – – 188 1,403 BB+/Ba1 and below /unrated £m BBB/Baa £m 55 – – – – 55 44 – – – – 44 BB+/Ba1 and below /unrated £m BBB/Baa £m 49 – – – – 49 60 – – – – Total £m 1,942 155 839 42 130 3,108 Total £m 1,324 146 2,253 67 188 60 3,978 GSK’s centrally managed cash reserves amounted to £2.2 billion at 31 December 2023, all available within three months. This includes £2.0 billion of cash managed by the Group for ViiV Healthcare, a 78.3% owned subsidiary. The Group has invested centrally managed liquid assets in bank deposits, Aaa/AAA rated US Treasury and Treasury repo only money market funds and Aaa/AAA rated liquidity funds. Wholesale and retail credit risk Outside the US, no customer accounts for more than 5% of the Group’s trade receivables balance. In the US, in line with other pharmaceutical companies, the Group sells its products through a small number of wholesalers in addition to hospitals, pharmacies, physicians and other groups. Sales to the three largest wholesalers amounted to approximately 79% (2022:79%) of the sales of the US Commercial Operations business in 2023. At 31 December 2023, the Group had trade receivables due from these three wholesalers totalling £3,319 million or 56% of total trade receivables (2022: £3,001 million or 55%). The Group is exposed to a concentration of credit risk in respect of these wholesalers such that, if one or more of them encounters financial difficulty, it could materially and adversely affect the Group’s financial results. This concentration of trade receivables is reflective of standard market practice in the US pharmaceuticals sector where a significant portion of sales are made to these three wholesalers, as disclosed in Note 6 'Turnover and segment information'. GSK’s assessment is that there is limited credit risk associated with these customers. The Group’s credit risk monitoring activities relating to these wholesalers include a review of their quarterly financial information and Standard & Poor’s credit ratings, development of GSK internal risk ratings, and establishment and periodic review of credit limits. All new customers are subject to a credit vetting process and existing customers will be subject to a review at least annually. The vetting process and subsequent reviews involve obtaining information including the customer’s status as a government or private sector entity, audited financial statements, credit bureau reports, debt rating agency (e.g. Moody’s, Standard & Poor’s) reports, payment performance history (from trade references, industry credit groups) and bank references. 245 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Trade receivables consist of amounts due from a large number of customers, spread across diverse industries and geographical areas. Ongoing credit evaluation is performed on the financial condition of accounts receivable and, where appropriate, credit insurance is purchased or factoring arrangements put in place. The amount of information obtained is proportional to the level of exposure being considered. The information is evaluated quantitatively (i.e. credit score) and qualitatively (i.e. judgement) in conjunction with the customer’s credit requirements to determine a credit limit. Trade receivables are grouped into customer segments that have similar loss patterns to assess credit risk while other receivables and other financial assets are assessed individually. Historical and forward-looking information is considered to determine the appropriate expected credit loss allowance. The Group believes there is no further credit risk provision required in excess of the allowance for expected credit losses (see Note 26, ‘Trade and other receivables’). Credit enhancements The Group uses credit enhancements including factoring and credit insurance to minimise the credit risk of the trade receivables in the Group. At 31 December 2023, £421 million (2022: £332 million) of trade receivables were insured in order to protect the receivables from loss due to credit risks such as default, insolvency and bankruptcy. Each Group entity assesses the credit risk of its private customers to determine if credit insurance is required. Factoring arrangements are managed locally by entities and are used to mitigate risk arising from large credit risk concentrations. All factoring arrangements are non-recourse. Fair value of financial assets and liabilities excluding lease liabilities The table on page 247 presents the carrying amounts and the fair values of the Group’s financial assets and liabilities excluding lease liabilities at 31 December 2023 and 31 December 2022. The fair values of the financial assets and liabilities are included at the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The following methods and assumptions are used to measure the fair values of significant financial instruments carried at fair value on the balance sheet: – Other investments – equity investments traded in an active market determined by reference to the relevant stock exchange quoted bid price; other equity investments determined by reference to the current market value of similar instruments, recent financing rounds or the discounted cash flows of the underlying net assets – Trade receivables carried at fair value – based on invoiced amount – Interest rate swaps, foreign exchange forward contracts, swaps and options – based on the present value of contractual cash flows or option valuation models using market sourced data (exchange rates or interest rates) at the balance sheet date – Cash equivalents carried at fair value – based on net asset value of the funds – Contingent consideration for business acquisitions and divestments – based on present values of expected future cash flows. The following methods and assumptions are used to estimate the fair values of significant financial instruments which are not measured at fair value on the balance sheet: – Receivables and payables, including put options, carried at amortised cost – approximates to the carrying amount – Liquid investments – approximates to the carrying amount – Cash and cash equivalents carried at amortised cost – approximates to the carrying amount – Long-term loans – based on quoted market prices (a level 1 fair value measurement) in the case of European and US Medium Term Notes; approximates to the carrying amount in the case of other fixed rate borrowings and floating rate bank loans – Short-term loans, overdrafts and commercial paper – approximates to the carrying amount because of the short maturity of these instruments. 246 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Financial assets measured at amortised cost: Other non-current assets Trade and other receivables Liquid investments Cash and cash equivalents Financial assets measured at fair value through other comprehensive income (FVTOCI): Other investments designated at FVTOCI Trade and other receivables Financial assets mandatorily measured at fair value through profit or loss (FVTPL): Current equity investments and other investments Other non-current assets Trade and other receivables Held for trading derivatives that are not in a designated and effective hedging relationship Cash and cash equivalents Derivatives designated and effective as hedging instruments (fair value movements through other comprehensive income) Total financial assets Financial liabilities measured at amortised cost: Borrowings excluding obligations under lease liabilities: – bonds in a designated hedging relationship – other bonds – bank loans and overdrafts – commercial paper in a designated hedging relationship – other commercial paper – other borrowings Total borrowings excluding lease liabilities Trade and other payables Other provisions Other non-current liabilities Financial liabilities mandatorily measured at fair value through profit or loss (FVTPL): Contingent consideration liabilities Held for trading derivatives that are not in a designated and effective hedging relationship Derivatives designated and effective as hedging instruments (fair value movements through other comprehensive income) Total financial liabilities excluding lease liabilities Notes b b a a,b a a,b a,b a,d,e a a,d,e Carrying value £m 9 3,829 42 1,942 2023 Fair value £m 9 3,829 42 1,942 Carrying value £m 21 3,789 67 1,324 2022 Fair value £m 21 3,789 67 1,324 931 2,541 931 2,541 1,153 2,327 1,153 2,327 2,410 2,410 4,401 4,401 18 23 98 994 18 23 98 994 13 50 165 2,399 13 50 165 2,399 32 32 25 25 12,869 12,869 15,734 15,734 d (5,348) (5,233) (6,322) (6,035) (10,456) (10,762) (12,017) (11,930) (191) (148) (667) (1) (191) (148) (667) (1) (447) (443) (748) (2) (447) (443) (748) (2) (16,811) (17,002) (19,979) (19,605) (13,383) (13,383) (14,065) (14,065) (199) (54) (199) (54) (63) (84) (63) (84) (6,662) (6,662) (7,068) (7,068) (78) (78) (77) (77) (36) (36) (106) (106) (37,223) (37,414) (41,442) (41,068) f c c c a,c a,d,e a,d,e Net financial assets and financial liabilities excluding lease liabilities (24,354) (24,545) (25,708) (25,334) The valuation methodology used to measure fair value in the above table is described and categorised on page 246. Trade and other receivables, Other non-current assets, Trade and other payables, Other provisions, Contingent consideration liabilities and Other non-current liabilities are reconciled to the relevant Notes on pages 249 to 250. 247 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Fair value of investments in GSK shares At 31 December 2023, the Employee Share Ownership Plan (ESOP) Trusts held GSK shares with a carrying value of £288 million (2022: £354 million) and a market value of £853 million (2022: £861 million) based on quoted market price. The shares are held by the ESOP Trusts to satisfy future exercises of options and awards under employee incentive schemes. In 2023, the carrying value, which is the lower of cost or expected proceeds, of these shares has been recognised as a deduction from other reserves. At 31 December 2023, GSK held Treasury shares at a cost of £3,447 million (2022: £3,797 million) which has been deducted from retained earnings. (a) Financial instruments held at fair value The following tables categorise the Group’s financial assets and liabilities held at fair value by the valuation methodology applied in determining their fair value. Where possible, quoted prices in active markets are used (Level 1). Where such prices are not available, the asset or liability is classified as Level 2, provided all significant inputs to the valuation model used are based on observable market data. If one or more of the significant inputs to the valuation model is not based on observable market data, the instrument is classified as Level 3. Other investments classified as Level 3 in the tables below comprise equity investments in unlisted entities with which the Group has entered into research collaborations and investments which provide access to biotechnology developments of potential interest. At 31 December 2023 Financial assets at fair value Financial assets measured at fair value through other comprehensive income (FVTOCI): Other investments designated at FVTOCI Trade and other receivables Financial assets mandatorily measured at fair value through profit or loss (FVTPL): Current equity investments and other investments Other non-current assets Trade and other receivables Held for trading derivatives that are not in a designated and effective hedging relationship Cash and cash equivalents Derivatives designated and effective as hedging instruments (fair value movements through OCI) Financial liabilities at fair value Financial liabilities mandatorily measured at fair value through profit or loss (FVTPL): Contingent consideration liabilities Held for trading derivatives that are not in a designated and effective hedging relationship Derivatives designated and effective as hedging instruments (fair value movements through OCI) At 31 December 2022 Financial assets at fair value Financial assets measured at fair value through other comprehensive income (FVTOCI): Other investments designated at FVTOCI Trade and other receivables Financial assets mandatorily measured at fair value through profit or loss (FVTPL): Current equity investments and other investments Other non-current assets Trade and other receivables Held for trading derivatives that are not in a designated and effective hedging relationship Cash and cash equivalents Derivatives designated and effective as hedging instruments (fair value movements through OCI) Financial liabilities at fair value Financial liabilities mandatorily measured at fair value through profit or loss (FVTPL): Contingent consideration liabilities Held for trading derivatives that are not in a designated and effective hedging relationship Derivatives designated and effective as hedging instruments (fair value movements through OCI) Level 1 £m Level 2 £m Level 3 £m Total £m 741 – – 2,541 190 – 931 2,541 2,204 – – – 994 – – – 23 98 – 32 206 2,410 18 – – – – 18 23 98 994 32 3,939 2,694 414 7,047 – – – – – (6,662) (6,662) (78) (36) (114) – – (78) (36) (6,662) (6,776) Level 1 £m Level 2 £m Level 3 £m Total £m 823 – – 2,327 4,087 – – – 2,399 – – – 50 165 – 25 330 – 314 13 – – – – 1,153 2,327 4,401 13 50 165 2,399 25 7,309 2,567 657 10,533 – – – – – (7,068) (7,068) (77) (106) – – (77) (106) (183) (7,068) (7,251) 248 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Movements in the year for financial instruments measured using Level 3 valuation methods are presented below: At 1 January Exchange adjustments Net losses recognised in the income statement Net (losses)/ gains recognised in other comprehensive income Contingent consideration related to business acquisitions in the period Settlement of contingent consideration liabilities Additions Disposals and settlements Transfers from Level 3 At 31 December 2023 £m 2022 £m (6,411) (5,657) – (863) (142) – 1,145 57 (25) (9) 46 (1,627) 91 (482) 1,137 97 (16) – (6,248) (6,411) Of the total net losses of £863 million (2022: £1,627 million) attributable to Level 3 financial instruments which were recognised in the income statement, £857 million (2022: £1,623 million) were in respect of financial instruments which were held at the end of the year and were reported in Other operating income/expense. Charges of £934 million (2022: £1,431 million) arose from remeasurement of the contingent consideration payable for the acquisition of the former Shionogi-ViiV Healthcare joint venture. A remeasurement gain of £210 million (2022: £231 million loss) arose from remeasurement of the contingent consideration payable for the acquisition of the Novartis Vaccines business. The acquisition of Affinivax in 2022 resulted in the additon of £482 million of contingent consideration to Level 3 financial liabilities, with charges of £44 million (2022: £17 million) arising on the remeasurement of the contingent consideration liability for the year. There were transfers of £9 million out of Level 3 financial instruments in the year (2022: no transfers into or out of Level 3 financial instruments). Movements arising on the translation of overseas net assets for consolidation into the Group accounts are recorded as exchange adjustments. Net gains and losses include the impact of other exchange movements. Financial liabilities measured using Level 3 valuation methods at 31 December included £5,718 million (2022: £5,890 million) in respect of contingent consideration payable for the acquisition in 2012 of the former Shionogi-ViiV Healthcare joint venture. This consideration is expected to be paid over a number of years and will vary in line with the future performance of specified products and movements in certain foreign currencies. A further £424 million (2022: £673 million) is in respect of contingent consideration for the acquisition in 2015 of the Novartis Vaccines business. This consideration is expected to be paid over a number of years and will vary in line with the future performance of specified products, the achievement of certain milestone targets and movements in certain foreign currencies. As a result of the acquisition of Affinivax in 2022, contingent consideration payable of £516 million (2022: £501 million) is recognised at 31 December. This consideration is expected to be paid over a number of years and will vary in line with the achievement of certain development milestones and movements in the USD/GBP exchange rate. Sensitivity analysis on these balances is provided in Note 33, ‘Contingent consideration liabilities’. (b) Trade and other receivables and Other non-current assets in scope of IFRS 9 The following table reconciles financial instruments within Trade and other receivables and Other non-current assets which fall within the scope of IFRS 9 to the relevant balance sheet amounts. The financial assets are predominantly non-interest earning. Non- financial instruments include tax receivables, pension surplus balances and prepayments, which are outside the scope of IFRS 9. At FVTPL £m At FVTOCI £m Amortised cost £m Financial instruments £m Non- financial instruments £m At FVTPL £m At FVTOCI £m Amortised cost £m Financial instruments £m Total £m 2023 Non- financial instruments £m 2022 Total £m 23 2,541 3,829 6,393 992 7,385 50 2,327 3,789 6,166 887 7,053 18 – 9 27 1,557 1,584 13 – 21 34 1,160 1,194 41 2,541 3,838 6,420 2,549 8,969 63 2,327 3,810 6,200 2,047 8,247 Trade and other receivables (Note 26) Other non-current assets (Note 24) Trade and other receivables include trade receivables of £5,905 million (2022: £5,452 million). The Group has portfolios in each of the three business models under IFRS 9: £23 million (2022: £50 million), measured at FVTPL, is held to sell the contractual cash flows as the receivables will be sold under a factoring arrangement, £2,541 million (2022: £2,327 million), measured at FVTOCI, is held to either collect or sell the contractual cash flows as the receivables may be sold under a factoring agreement, and £3,341 million (2022: £3,075 million), measured at amortised cost, is held to collect the contractual cash flows and there is no factoring agreement in place. 249 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued (c) Trade and other payables, Other provisions, Contingent consideration liabilities and Other non- current liabilities in scope of IFRS 9 The following table reconciles financial instruments within Trade and other payables, Other provisions, Contingent consideration liabilities and Other non-current liabilities which fall within the scope of IFRS 9 to the relevant balance sheet amounts. The financial liabilities are predominantly non-interest bearing. Non-financial instruments include payments on account, tax and social security payables and provisions which do not arise from contractual obligations to deliver cash or another financial asset, which are outside the scope of IFRS 9. Trade and other payables (Note 29) Other provisions (Note 32) Contingent consideration liabilities (Note 33) Other non-current liabilities (Note 34) At FVTPL £m Amortised cost £m Financial instruments £m Non- financial instruments £m Total £m At FVTPL £m Amortised cost £m Financial instruments £m Non- financial instruments £m 2023 2022 Total £m – – (13,383) (13,383) (2,461) (15,844) (199) (199) (1,040) (1,239) – – (14,065) (14,065) (2,198) (16,263) (63) (63) (1,121) (1,184) (6,662) – (6,662) – (6,662) (7,068) – (7,068) – (7,068) – (54) (54) (1,053) (1,107) – (84) (84) (815) (899) (6,662) (13,636) (20,298) (4,554) (24,852) (7,068) (14,212) (21,280) (4,134) (25,414) (d) Derivative financial instruments and hedging programmes Derivatives are only used for economic hedging purposes and not as speculative investments and are classified as ‘held for trading’, other than designated and effective hedging instruments, and are presented as current assets or liabilities if they are expected to be settled within 12 months after the end of the reporting period, otherwise they are classified as non-current. The Group has the following derivative financial instruments: Current Cash flow hedges – Foreign exchange contracts (net principal amount – £175 million (2022: £167 million)) Net investment hedges – Foreign exchange contracts (net principal amount – £12,339 million (2022: £7,197 million)) Derivatives designated and effective as hedging instruments Current Foreign exchange contracts (net principal amount – £10,375 million (2022: £5,908 million)) Embedded and other derivatives Derivatives classified as held for trading Total derivative instruments 2023 Fair value 2022 Fair value Assets £m Liabilities £m Assets £m Liabilities £m – 32 32 98 – 98 130 (2) (34) (36) (78) – (78) (114) 5 20 25 163 2 165 190 – (106) (106) (76) (1) (77) (183) 250 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Fair value hedges At 31 December 2023 and 31 December 2022, the Group had no designated fair value hedges. Net investment hedges At 31 December 2023, certain foreign exchange contracts were designated as net investment hedges in respect of the foreign currency translation risk arising on consolidation of the Group’s net investment in its European (Euro), American (USD), Singaporean (SGD), Canadian (CAD) and Japanese (JPY) foreign operations as shown in the table below. The carrying value of bonds on page 247 included £5,348 million (2022: £6,322 million) that were designated as hedging instruments in net investment hedges. Cash flow hedges During 2022 and 2023, the Group entered into forward foreign exchange contracts which have been designated as cash flow hedges. These were entered into to hedge the foreign exchange exposure arising on cash flows from Euro denominated coupon payments relating to notes issued under the Group’s European Medium Term Note programme, and to hedge foreign currency payments due on acquisitions, and collaboration or licensing arrangements. The Group manages its cash flow interest rate risk by using floating-to-fixed interest rate swaps. In addition, the Group carries a balance in reserves that arose from pre-hedging fluctuations in long-term interest rates when pricing bonds issued in prior years and in the current year. The balance is reclassified to finance costs over the life of these bonds. Foreign exchange risk In the current year, the Group has designated certain foreign exchange forward contracts and swaps as cash flow and net investment hedges. Foreign exchange derivative financial assets and liabilities are presented in the line ‘Derivative financial instruments’ (either as assets or liabilities) on the Consolidated balance sheet. The following tables detail the foreign exchange forward contracts and swaps outstanding at the end of the reporting period, as well as information on the related hedged items. Hedge effectiveness is determined at the inception of the hedge relationship, and through periodic prospective effectiveness assessments to ensure that an economic relationship exists between the hedged item and hedging instrument. The Group enters into hedge relationships where the critical terms of the hedging instrument match exactly with the terms of the hedged item, and so a qualitative assessment of effectiveness is performed. If changes in circumstances affect the terms of the hedged item such that the critical terms no longer match exactly with the critical terms of the hedging instrument, the Group uses the hypothetical derivative method to assess effectiveness. The main source of hedge ineffectiveness in these hedging relationships is the effect of the counterparty and the Group’s own credit risk on the fair value of the foreign exchange forward contracts and swaps, which is not reflected in the fair value of the hedged item attributable to changes in foreign exchange rates. No other sources of ineffectiveness emerged from these hedging relationships. No ineffectiveness was recorded from cash flow hedges in 2023 (2022: £nil). No ineffectiveness was recorded from net investment hedges (2022: £nil). Hedging instruments Cash flow hedges Foreign exchange contracts Buy foreign currency: Less than 3 months 3 to 6 months Over 6 months Sell foreign currency: Less than 3 months Average exchange rate Foreign currency Net Notional value £m Carrying value £m 2023 Periodic change in value for calculating hedge ineffectiveness £m 1.27 – 1.25 1.16 USD – USD EUR 145 – 35 (5) 175 (1) – (1) – (2) (1) – (1) – (2) 251 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Hedging instruments Net investment hedges Foreign exchange contracts Sell foreign currency: Less than 3 months Over 6 months Borrowings: Less than 3 months 3 to 6 months Over 6 months Hedged items Cash flow hedges Variability in cash flows from a highly probable forecast transaction Net investment hedges Net investment in foreign operations Hedging instruments Cash flow hedges Foreign exchange contracts Buy foreign currency: Less than 3 months 3 to 6 months Over 6 months Sell foreign currency: Less than 3 months Average exchange rate Foreign currency Net notional value £m Carrying value £m 2023 Periodic change in value for calculating hedge ineffectiveness £m 1.15 181.42 1.27 1.67 1.66 EUR JPY USD CAD SGD EUR – JPY EUR 9,146 133 2,633 260 167 148 – 236 5,127 17,850 (12) (1) 8 2 1 (148) – (235) (5,113) (5,498) 126 28 97 10 7 12 – (3) 125 402 2023 Periodic change in value for calculating hedge ineffectiveness £m Cumulative balance in cash flow hedge reserve/foreign currency translation reserve for continuing hedges £m Balance in cash flow hedge reserve arising from hedging relationships for which hedge accounting is no longer applied £m 2 (402) (2) (725) Average exchange rate Foreign currency Net notional value £m Carrying value £m 1.23 1.16 1.15 1.14 USD EUR EUR EUR 100 50 24 (7) 167 2 2 1 – 5 – – 2022 Periodic change in value for calculating hedge ineffectiveness £m 2 2 1 – 5 252 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Hedging instruments Net investment hedges Foreign exchange contracts Sell foreign currency: Less than 3 months 3 to 6 months Over 6 months Borrowings: Less than 3 months 3 to 6 months Over 6 months Hedged items Cash flow hedges Variability in cash flows from a highly probable forecast transaction Variability in cash flows from foreign exchange exposure arising on Euro denominated coupon payments relating to debt issued Net investment hedges Net investment in foreign operations Average exchange rate Foreign currency Net notional value £m Carrying value £m 2022 Periodic change in value for calculating hedge ineffectiveness £m 1.14 160.90 – 1.57 1.59 EUR JPY – CAD SGD EUR EUR EUR 6,559 194 – 270 174 293 150 6,341 13,981 (103) (3) – 18 2 (293) (150) (6,322) (6,851) (317) (9) – 15 1 (4) (3) (300) (617) 2022 Periodic change in value for calculating hedge ineffectiveness £m Cumulative balance in cash flow hedge reserve/foreign currency translation reserve for continuing hedges £m Balance in cash flow hedge reserve arising from hedging relationships for which hedge accounting is no longer applied £m (2) (3) 617 2 2 (1,120) – – – – £nil (2022: £3 million) of balances in the cash flow hedge reserve arise from hedging relationships for which hedge accounting is no longer applied. The following table details the effectiveness of the hedging relationships and the amounts reclassified from the hedging reserve to profit or loss: Amount reclassified to profit or loss Amount reclassified to balance sheet 2023 Hedging gains/(losses) recognised in reserves £m Amount of hedge ineffectiveness recognised in profit or loss £m Line item in profit or loss in which hedge ineffectiveness is included Hedged future cash flows no longer expected to occur £m Due to hedged item affecting profit or loss £m Line item in profit or loss in which reclassification adjustment is included Due to hedged item affecting balance sheet £m Line item in balance sheet in which reclassification adjustment is included (41) (1) – – Finance income or expense Finance income or expense – – – – Finance income or expense Finance income or expense 37 – Intangible assets – 402 – Finance income or expense – 7 Other income or expense – – 253 Cash flow hedges Variability in cash flows from a highly probable forecast transaction Variability in cash flows from foreign exchange exposure arising on Euro denominated coupon payments relating to debt issued Net investment hedges Net investment in foreign operations Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Amount reclassified to profit or loss Amount reclassified to balance sheet 2022 Hedging gains/(losses) recognised in reserves £m Amount of hedge ineffectiveness recognised in profit or loss £m Line item in profit or loss in which hedge ineffectiveness is included Hedged future cash flows no longer expected to occur £m Due to hedged item affecting profit or loss £m Line item in profit or loss in which reclassification adjustment is included Due to hedged item affecting balance sheet £m Line item in balance sheet in which reclassification adjustment is included Cash flow hedges Variability in cash flows from a highly probable forecast transaction Variability in cash flows from foreign exchange exposure arising on Euro denominated coupon payments relating to debt issued Net investment hedges Net investment in foreign operations (5) 4 – – Finance income or expense Finance income or expense (617) – Finance income or expense – – – – – (2) Finance income or expense 8 – Intangible assets – 194 Discontinued Operations (1) – – (1) Reclassified to the Consolidated income statement on the demerger of the Consumer Healthcare business. Interest rate risk The Group manages its cash flow interest rate risk by using floating-to-fixed interest rate swaps, where at quarterly intervals the difference between fixed contract rates and floating rate interest amounts calculated by reference to the agreed notional principal amounts are exchanged. There are none of these swaps outstanding at 31 December 2023 or at 31 December 2022. The only impact on these financial statements of interest rate swaps is where the interest rate risk on an element of future debt issuance has been managed by entering into forward starting interest rate swaps, effectively to lock in the interest rates on the debt in advance. These were closed out at the time of issuing the debt, and the resulting gain or loss held in the Cash flow hedge reserve and reclassified to income statement as the interest payments on the debt impacted the income statement. Forward starting interest rate swaps Forward starting interest rate contracts, exchanging floating interest for fixed interest, were designated as cash flow hedges to hedge the interest variability of the interest cash flows associated with future fixed rate debt. Interest rate swaps Interest rate swap contract assets and liabilities are presented (when applicable) in the line ‘Derivative financial instruments’ (either as assets or liabilities) on the Consolidated balance sheet. £21 million (2022: £24 million) of balances in the cash flow hedge reserve arise from hedge relationships for which hedge accounting is no longer applied. The following table details the effectiveness of the hedging relationships and the amounts reclassified from the hedging reserve to profit or loss: Amount reclassified to profit or loss 2023 Hedging gains/(losses) recognised in reserves £m Amount of hedge ineffectiveness recognised in profit or loss £m Line item in profit or loss in which hedge ineffectiveness is included Due to hedged future cash flows no longer expected to occur £m Line item in profit or loss in which reclassification adjustment is included Due to hedged item affecting profit or loss £m – – Finance income or expense – 4 Finance income or expense Cash flow hedges Pre-hedging of long-term interest rates: Matured in the past 254 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued Amount reclassified to profit or loss 2022 Hedging gains/(losses) recognised in reserves £m Amount of hedge ineffectiveness recognised in profit or loss £m Line item in profit or loss in which hedge ineffectiveness is included Due to hedged future cash flows no longer expected to occur £m Line item in profit or loss in which reclassification adjustment is included Due to hedged item affecting profit or loss £m (23) – Finance income or expense – 3 Finance income or expense Cash flow hedges Pre-hedging of long-term interest rates: Matured in the past (e) Offsetting of financial assets and liabilities Financial assets and liabilities are offset and the net amount reported in the balance sheet where there is a legally enforceable right to offset the recognised amounts, and there is an intention to settle on a net basis or realise the asset and settle the liability simultaneously. There are also arrangements that do not meet the criteria for offsetting but still allow for the related amounts to be offset in certain circumstances, such as bankruptcy or the termination of a contract. The following tables set out the financial assets and liabilities that are offset, or subject to enforceable master netting arrangements and other similar agreements but not offset, as at 31 December 2023 and 31 December 2022. The column ‘Net amount’ shows the impact on the Group’s balance sheet if all offset rights were exercised. 31 December 2023 Financial assets Trade and other receivables Derivative financial instruments Financial liabilities Trade and other payables Derivative financial instruments 31 December 2022 Financial assets Trade and other receivables Derivative financial instruments Financial liabilities Trade and other payables Derivative financial instruments Gross financial assets/ (liabilities) £m Gross financial (liabilities)/ assets set off £m Net financial assets/ (liabilities) per balance sheet £m Related amounts not set off in the balance sheet £m 6,394 130 (1) – 6,393 130 – (108) Net £m 6,393 22 (13,384) (114) 1 – (13,383) (114) – 108 (13,383) (6) Gross financial assets/ (liabilities) £m Gross Financial (liabilities)/ assets offset £m Net financial assets/ (liabilities) £m Related amounts not offset £m Net balance £m 6,166 190 (14,065) (183) – – – – 6,166 190 – (163) 6,166 27 (14,065) (183) – 163 (14,065) (20) Amounts which do not meet the criteria for offsetting on the balance sheet but could be settled net in certain circumstances principally relate to derivative transactions under ISDA (International Swaps and Derivatives Association) agreements where each party has the option to settle amounts on a net basis in the event of default of the other party. As there is presently not a legally enforceable right of offset, these amounts have not been offset in the balance sheet, but have been presented separately in the table above. 255 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued (f) Debt interest rate repricing table The following table sets out the exposure of the Group to interest rates on debt, including commercial paper. The maturity analysis of fixed rate debt is stated by contractual maturity and of floating rate debt by interest rate repricing dates. For the purpose of this table, debt is defined as all classes of borrowings other than lease liabilities. Floating and fixed rate debt less than one year Between one and two years Between two and three years Between three and four years Between four and five years Between five and ten years Greater than ten years Total Original issuance profile: Fixed rate interest Floating rate interest 2023 Total debt £m (2,657) (1,434) (1,475) (740) (2,350) (3,031) (5,124) (16,811) 2022 Total £m (3,785) (1,714) (1,490) (1,505) (748) (4,736) (6,001) (19,979) (15,847) (18,355) (964) (1,624) (16,811) (19,979) 256 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued (g) Sensitivity analysis The tables below illustrate the estimated impact on the income statement and equity as a result of hypothetical market movements in foreign exchange and interest rates in relation to the Group’s financial instruments. The range of variables chosen for the sensitivity analysis reflects management’s view of changes which are reasonably possible over a one-year period. Foreign exchange sensitivity The Group operates internationally and is primarily exposed to foreign exchange risk in relation to Sterling against movements in US Dollar, Euro and Japanese Yen. Foreign exchange risk arises from the translation of financial assets and liabilities which are not in the functional currency of the entity that holds them. Based on the Group’s net financial assets and liabilities as at 31 December, a weakening and strengthening of Sterling against these currencies, with all other variables held constant, is illustrated in the tables below. The tables exclude financial instruments that expose the Group to foreign exchange risk where this risk is fully hedged with another financial instrument. Income statement impact of non-functional currency foreign exchange exposures 10 cent appreciation of the US Dollar 15 cent appreciation of the US Dollar 10 cent appreciation of the Euro 15 cent appreciation of the Euro 10 yen appreciation of the Yen 15 yen appreciation of the Yen Income statement impact of non-functional currency foreign exchange exposures 10 cent depreciation of the US Dollar 15 cent depreciation of the US Dollar 10 cent depreciation of the Euro 15 cent depreciation of the Euro 10 yen depreciation of the Yen 15 yen depreciation of the Yen 2023 2022 Increase/(decrease) in income £m Increase/(decrease) in income £m 61 97 (4) (7) – – 99 155 (7) (12) – (1) 2023 2022 Increase/(decrease) in income £m Increase/(decrease) in income £m (52) (76) 4 5 – – (84) (121) 6 9 – – The equity impact, shown below, for foreign exchange sensitivity relates to derivative and non-derivative financial instruments hedging the Group’s net investments in its European (Euro) foreign operations and cash flow hedges of its foreign exchange exposure arising on Euro denominated coupon payments relating to notes issued under the Group’s European Medium Term Note programme. Equity impact of non-functional currency foreign exchange exposures 10 cent appreciation of the US Dollar 15 cent appreciation of the US Dollar 10 cent appreciation of the Euro 15 cent appreciation in Euro Equity impact of non-functional currency foreign exchange exposures 10 cent depreciation of the US Dollar 15 cent depreciation of the US Dollar 10 cent depreciation of the Euro 15 cent depreciation of the Euro 2023 2022 Increase/(decrease) in equity £m Increase/(decrease) in equity £m (209) (327) (1,372) (2,160) – – (1,290) (2,034) 2023 2022 Increase/(decrease) in equity £m Increase/(decrease) in equity £m 178 258 1,152 1,662 – – 1,080 1,557 257 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued The tables below present the Group’s sensitivity to a weakening and strengthening of Sterling against the relevant currency based on the composition of net debt as shown in Note 30, 'Net debt', adjusted for the effects of foreign exchange derivatives that are not part of net debt but affect future foreign currency cash flows. Impact of foreign exchange movements on net debt 10 cent appreciation of the US Dollar 15 cent appreciation of the US Dollar 10 cent appreciation of the Euro 15 cent appreciation of the Euro 10 yen appreciation of the Yen 15 yen appreciation of the Yen Impact of foreign exchange movements on net debt 10 cent depreciation of the US Dollar 15 cent depreciation of the US Dollar 10 cent depreciation of the Euro 15 cent depreciation of the Euro 10 yen depreciation of the Yen 15 yen depreciation of the Yen 2023 2022 (Increase)/decrease in net debt £m (Increase)/decrease in net debt £m (622) (974) 386 609 (5) (7) (999) (1,570) 11 17 13 20 2023 2022 (Increase)/decrease in net debt £m (Increase)/decrease in net debt £m 531 769 (325) (468) 4 6 846 1,222 (9) (13) (12) (17) Interest rate sensitivity The Group is exposed to interest rate risk on its outstanding borrowings and investments where any changes in interest rates will affect future cash flows or the fair values of financial instruments. The majority of debt is issued at fixed interest rates and changes in the floating rates of interest do not significantly affect the Group’s net interest charge, although the majority of cash and liquid investments earn floating rates of interest. The table below hypothetically shows the Group’s sensitivity to changes in interest rates in relation to Sterling, US Dollar and Euro floating rate financial assets and liabilities. A 1% (100 basis points) or 1.5% (150 basis points) movement in EUR, USD or Sterling interest rates is not deemed to have a material effect on equity. A 1% (100 basis points) or 1.5% (150 basis points) decrease in EUR, USD or Sterling interest rates would have an equal and opposite impact to that shown below. Income statement impact of interest rate movements 1% (100 basis points) increase in Sterling interest rates 1.5% (150 basis points) increase in Sterling interest rates 1% (100 basis points) increase in US Dollar interest rates 1.5% (150 basis points) increase in US Dollar interest rates 1% (100 basis points) increase in Euro interest rates 1.5% (150 basis points) increase in Euro interest rates 2023 2022 Increase/(decrease) in income £m Increase/(decrease) in income £m 41 62 (34) (51) (9) (13) 36 55 (34) (51) (13) (19) 258 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 44. Financial instruments and related disclosures continued (h) Contractual cash flows for non-derivative financial liabilities and derivative instruments The following tables provide an analysis of the anticipated contractual cash flows including interest payable for the Group’s non- derivative financial liabilities on an undiscounted basis. For the purpose of this table, debt is defined as all classes of borrowings except for lease liabilities. Interest is calculated based on debt held at 31 December without taking account of future issuance. Floating rate interest is estimated using the prevailing interest rate at the balance sheet date. Cash flows in foreign currencies are translated using spot rates at 31 December. At 31 December 2023 Due in less than one year Between one and two years Between two and three years Between three and four years Between four and five years Between five and ten years Greater than ten years Gross contractual cash flows At 31 December 2022 Due in less than one year Between one and two years Between two and three years Between three and four years Between four and five years Between five and ten years Greater than ten years Debt £m (2,660) (1,436) (1,477) (742) (2,359) (3,054) (5,172) (16,900) Debt £m (3,786) (1,717) (1,496) (1,508) (751) (4,765) (6,063) Gross contractual cash flows (20,086) Interest on debt £m (547) (507) (466) (449) (399) (1,611) (1,467) (5,446) Interest on debt £m (594) (570) (531) (489) (472) (1,810) (1,856) (6,322) Lease liabilities £m (156) (214) (134) (114) (88) (325) (176) Finance charge on lease liabilities £m Trade payables and other liabilities not in net debt £m Total £m (41) (36) (31) (27) (23) (75) (21) (14,526) – (17,930) (1,469) – (1,150) – (1,406) – (940) – (2,037) – (1,043) – (3,662) (3,258) (2,738) (3,809) (7,102) (7,879) (1,207) (254) (22,571) – (46,378) Lease liabilities £m (167) (201) (127) (97) (80) (201) (135) Finance charge on lease liabilities £m Trade payables and other liabilities not in net debt £m Total £m (15,362) (19,934) (25) (22) (19) (15) (13) (41) (11) (1,097) (1,034) (1,277) (1,008) (2,641) (1,134) (3,607) (3,207) (3,386) (2,324) (9,458) (9,199) (51,115) (1,008) (146) (23,553) The table below provides an analysis of the anticipated contractual cash flows for the Group’s derivative instruments excluding equity options which do not give rise to cash flows, and other embedded derivatives, which are not material, using undiscounted cash flows. Cash flows in foreign currencies are translated using spot rates at 31 December. The gross cash flows of foreign exchange contracts are presented for the purpose of this table although, in practice, the Group uses standard settlement arrangements to reduce its liquidity requirements on these instruments. 2023 2022 Gross cash inflows Gross cash outflows Gross cash inflows Gross cash outflows Foreign exchange forward contracts and swaps £m Foreign exchange forward contracts and swaps £m Foreign exchange forward contracts and swaps £m Foreign exchange forward contracts and swaps £m Less than one year Gross contractual cash flows 31,961 31,961 (31,944) (31,944) 24,418 24,418 (24,410) (24,410) 259 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 45. Employee share schemes GSK operates several employee share schemes, including the Share Value Plan, whereby awards are granted to employees to acquire shares or ADS in GSK plc at no cost after a three-year vesting period and the Performance Share Plan, whereby awards are granted to employees to acquire shares or ADS in GSK plc at no cost, subject to the achievement by the Group of specified performance targets. The granting of these restricted share awards has replaced the granting of options to employees as the cost of the schemes more readily equates to the potential gain to be made by the employee. The Group also operates savings related share option schemes, whereby options are granted to employees to acquire shares in GSK plc at a discounted price. Grants of restricted share awards are normally exercisable at the end of the three-year vesting or performance period. Awards are normally granted to employees to acquire shares or ADS in GSK plc but in some circumstances may be settled in cash. Grants under savings-related share option schemes are normally exercisable after three years’ saving. In accordance with UK practice, the majority of options under the savings-related share option schemes are granted at a price 20% below the market price ruling at the date of grant. Options under historical share option schemes were granted at the market price ruling at the date of grant. The total charge for share-based incentive plans in 2023 was £321 million (2022: £314 million; 2021: £345 million). Of this amount, £244 million (2022: £243 million; 2021: £258 million) arose from the Share Value Plan. See Note 9, ‘Employee costs’ for further details. GSK share award schemes Share Value Plan Under the Share Value Plan, share awards are granted to certain employees at no cost. The awards vest after two and a half to three years and there are no performance criteria attached. The fair value of these awards is determined based on the closing share price on the day of grant, after deducting the expected future dividend yield of 3.8% (2022: 3.2%; 2021: 3.8%) over the duration of the award. Number of shares and ADS issuable Shares Number (000) Weighted fair value ADS Number (000) Weighted fair value At 1 January 2021 Awards granted Awards exercised Awards cancelled At 31 December 2021 Awards granted Awards exercised Awards cancelled At 31 December 2022 Awards granted Awards exercised Awards cancelled At 31 December 2023 £13.28 £13.00 £12.79 28,874 11,220 (10,074) (1,776) 28,244 10,987 (9,538) (1,718) 27,975 11,548 (8,599) (1,144) 29,780 $36.68 $30.64 $31.65 16,116 6,358 (5,240) (1,705) 15,529 6,133 (4,919) (1,314) 15,429 6,449 (4,856) (797) 16,225 Performance Share Plan Under the Performance Share Plan, share awards are granted to Directors and senior executives at no cost. The percentage of each award that vests is based upon the performance of the Group over a defined measurement period with dividends reinvested during the same period. For awards granted from 2020, the performance conditions are based on four measures over a three-year performance period. These are adjusted free cash flow (30%), TSR (30%), R&D new product performance (20%) and pipeline progress (20%). For awards granted from 2022, the performance conditions are based on five measures over a three-year performance period. These are TSR (30%), pipeline progress (20%), profit measure (20%), sale measure (20%) and ESG environment (10%). The fair value of the awards is determined based on the closing share price on the day of grant. For TSR performance elements, this is adjusted by the likelihood of that condition being met, as assessed at the time of grant. During 2023, awards were made of 4.3 million shares at a weighted fair value of £12.40 and 1.0 million ADS at a weighted fair value of £29.96. At 31 December 2023, there were outstanding awards over 13.3 million shares and 2.7 million ADS. 260 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 45. Employee share schemes continued Share options and savings-related options For the purposes of valuing savings-related options to arrive at the share-based payment charge, a Black-Scholes option pricing model has been used. The assumptions used in the model are as follows: Risk-free interest rate Dividend yield Volatility Expected life Savings-related options grant price (including 20% discount) Options outstanding for the Share Save Plan At 31 December 2023 Range of exercise prices on options outstanding at year end Weighted average market price on exercise during year Weighted average remaining contractual life 2023 Grant 2022 Grant 2021 Grant 4.57% 4.0% 34% 3.37% 3.3% 36% 0.74% 3.8% 27% 3 years 3 years 3 years £11.20 £11.39 £12.07 Savings-related share option schemes Number 000 6,196 Weighted exercise price £11.13 £10.34 — £14.15 £14.32 1.9 years Options over 1.9 million shares were granted during the year under the savings-related share option scheme at a weighted average fair value of £4.08. At 31 December 2023, 4.2 million of the savings-related share options were not exercisable. There has been no change in the effective exercise price of any outstanding options during the year. Employee Share Ownership Plan Trusts The Group sponsors Employee Share Ownership Plan (ESOP) Trusts to acquire and hold shares in GSK plc to satisfy awards made under employee incentive plans and options granted under employee share option schemes. The trustees of the ESOP Trusts purchase shares with finance provided by the Group by way of loans or contributions. The costs of running the ESOP Trusts are charged to the income statement. Shares held by the ESOP Trusts are deducted from other reserves and amortised down to the value of proceeds, if any, receivable from employees on exercise by a transfer to retained earnings. The trustees have waived their rights to dividends on the shares held by the ESOP Trusts. At 31 December 2023, 58,817,197 shares were held in the ESOP Trusts, out of which 58,493,518 were held for the future exercise of share options and share awards and 323,679 shares were held for the Executive Supplemental Savings Plan. Shares held for share award schemes Number of shares (000) Nominal value Carrying value Market value Shares held for share option schemes Number of shares (000) Nominal value Carrying value Market value 2023 58,817 2022 59,814 £m 18 288 853 2023 – £m – – – £m 19 353 861 2022 65 £m – 1 1 261 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 46. Principal Group companies The following represent the principal subsidiaries and their countries of incorporation of the Group at 31 December 2023. The equity share capital of these entities is shown in the percentage columns. All companies are incorporated in their principal country of operation except where stated. Scotland GSK (No.1) Scottish Limited Partnership US Affinivax, Inc Corixa Corporation GlaxoSmithKline Capital Inc. GlaxoSmithKline Holdings (Americas) Inc. GlaxoSmithKline LLC GSK Equity Investments, Limited Human Genome Sciences, Inc Stiefel Laboratories, Inc Tesaro, Inc. ViiV Healthcare Company Others Glaxo Saudi Arabia Limited (Saudi Arabia) Glaxo Wellcome Manufacturing Pte Ltd (Singapore) GlaxoSmithKline (Thailand) Limited (Thailand) GlaxoSmithKline Australia Pty Ltd (Australia) GlaxoSmithKline Brasil Limitada (Brazil) GlaxoSmithKline Far East B.V. (Taiwan) GlaxoSmithKline Ilaclari Sanayi ve Ticaret A.S. (Turkey) GlaxoSmithKline Inc. (Canada) GlaxoSmithKline K.K. (Japan) GlaxoSmithKline Korea Limited (Republic of Korea) GlaxoSmithKline Limited (Hong Kong) GlaxoSmithKline Mexico S.A. de C.V. (Mexico) GlaxoSmithKline Pakistan Limited (Pakistan) GlaxoSmithKline Pharmaceuticals Limited (India) GSK Enterprise Management Co, Ltd (China) GSK Pharma Vietnam Company Limited (Vietnam) ID Biomedical Corporation of Quebec (Canada) ViiV Healthcare K.K (Japan) ViiV Healthcare ULC (Canada) % 100 % 100 100 100 100 100 100 100 100 100 78.3 % 100 100 100 100 100 100 100 100 100 100 100 100 82.6 75 100 100 100 78.3 78.3 England Glaxo Group Limited Glaxo Operations UK Limited Glaxo Wellcome UK Limited GlaxoSmithKline Capital plc GlaxoSmithKline Export Limited GlaxoSmithKline Finance plc GlaxoSmithKline Holdings Limited(a) GlaxoSmithKline IHC Limited GlaxoSmithKline Intellectual Property (No.2) Limited GlaxoSmithKline Intellectual Property (No.3) Limited GlaxoSmithKline Intellectual Property (No.4) Limited GlaxoSmithKline Intellectual Property Development Limited GlaxoSmithKline Intellectual Property Limited GlaxoSmithKline Research & Development Limited GlaxoSmithKline Services Unlimited(a) GlaxoSmithKline UK Limited GlaxoSmithKline US Trading Limited Setfirst Limited SmithKline Beecham Limited ViiV Healthcare Finance Limited ViiV Healthcare UK (No.3) Limited Viiv Healthcare UK Limited Europe GlaxoSmithKline AG (Switzerland) Glaxo Wellcome Production S.A.S (France) GlaxoSmithKline B.V. (Netherlands) GlaxoSmithKline Biologicals SA (Belgium) GlaxoSmithKline GmbH & Co. KG (Germany) GlaxoSmithKline Manufacturing SpA (Italy) GlaxoSmithKline Pharma GmbH (Austria) GlaxoSmithKline Pharmaceuticals SA (Belgium) GlaxoSmithKline S.A. (Spain) GlaxoSmithKline S.p.A. (Italy) GlaxoSmithKline Single Member A.E.B.E. (Greece) GlaxoSmithKline Trading Services Limited (Republic of Ireland)(b) GSK Capital B.V. (Netherlands)(b) GSK Services Sp z o.o. (Poland) GSK Vaccines GmbH (Germany) GSK Vaccines S.r.l. (Italy) JSC GlaxoSmithKline Trading (Russia) Laboratoire GlaxoSmithKline (France) Laboratorios ViiV Healthcare, S.L. (Spain) ViiV Healthcare GmbH (Germany) ViiV Healthcare S.r.l. (Italy) ViiV Healthcare SAS (France) % 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 78.3 78.3 78.3 % 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 78.3 78.3 78.3 78.3 Tax resident in UK. (a) Directly held wholly-owned subsidiary of GSK plc. (b) The subsidiaries and associates listed above principally affect the figures in the Group’s financial statements. Each of GlaxoSmithKline Capital Inc., GlaxoSmithKline Capital plc, GlaxoSmithKline Finance plc, GSK Capital BV and GlaxoSmithKline LLC, is a wholly-owned finance subsidiary of the company, and the Company has fully and unconditionally guaranteed the securities issued by each of GlaxoSmithKline Capital Inc., GlaxoSmithKline Capital plc, GlaxoSmithKline Finance plc, GSK Capital BV and GlaxoSmithKline LLC. + See pages 306 to 314 for a complete list of subsidiary undertakings, associates and joint ventures, which form part of these financial statements. 262 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 47. Legal proceedings The Group is involved in significant legal and administrative proceedings, principally product liability, intellectual property, tax, anti-trust, consumer fraud and governmental investigations. The most significant of these matters, other than tax matters, are described below. The Group makes provision for these proceedings on a regular basis as summarised in Note 2, ‘Accounting principles and policies’ and Note 32, ‘Other provisions’. Note 2 also describes when disclosure is made of proceedings for which there is no provision. Legal expenses incurred and provisions related to legal claims are charged to selling, general and administration costs. The Group does not believe that information about the amount sought by plaintiffs, if that is known, would be meaningful with respect to those legal proceedings. This is due to a number of factors, including, but not limited to, the stage of proceedings, the entitlement of parties to appeal a decision and clarity as to theories of liability, damages and governing law. At 31 December 2023, the Group’s aggregate provision for legal and other disputes (not including tax matters described in Note 14, ‘Taxation’) was £267 million. There can be no assurance that any losses that result from the outcome of any legal proceedings will not materially exceed the amount of the provisions reported in the Group’s financial statements. If this were to happen, it could have a material adverse impact on the results of operations of the Group in the reporting period in which the judgements are incurred or the settlements entered into. Intellectual property Intellectual property claims include challenges to the validity and enforceability of the Group’s patents on various products or processes as well as assertions of non-infringement of those patents. A loss in such cases could result in loss of patent protection for the product at issue. The consequences of any such loss could be a significant decrease in sales of that product and could materially affect future results of operations for the Group. Coreg In 2014, GSK initiated suit against Teva for inducing infringement of its patent relating to the use of carvedilol (Coreg) in decreasing mortality caused by congestive heart failure. In June 2017, the case proceeded to a jury trial in the US District Court for the District of Delaware. The jury returned a verdict in GSK’s favour, awarding GSK lost profits and reasonable royalties for a total award of $235.51 million. On 29 March 2018, the trial judge ruled on post-trial motions filed by Teva and found that substantial evidence at trial did not support the jury’s finding of induced infringement, overturning the jury award. GSK appealed, and on 2 October 2020, a divided panel of the Court of Appeals for the Federal Circuit reversed the district court’s ruling and reinstated the jury award in GSK’s favour. On 2 December 2020, Teva filed a petition for rehearing en banc. The court granted Teva’s petition, but only for a rehearing by the three-member panel that issued the original decision. On 5 August 2021, the original panel issued its rehearing opinion where the majority again reinstated the jury’s damages award of $235.51 million in GSK’s favour. Teva again filed a petition for rehearing en banc which was rejected by the Court of Appeals for the Federal Circuit on 11 February 2022. On 11 July 2022, Teva filed a petition for writ of certiorari with the Supreme Court of the United States seeking to overturn the Federal Court decision. On 15 May 2023, the US Supreme Court denied Teva’s request. Certain issues remain to be resolved at the District Court and the parties await the scheduling of a status conference. Dolutegravir Proceedings – Tivicay/Triumeq In September 2021, ViiV Healthcare received a paragraph IV letter from Lupin relating to the Tivicay 5mg dosage for oral suspension, challenging only the crystal form patent. On 2 November 2021, ViiV Healthcare filed suit against Lupin in the US District Court for the District of Delaware. In March 2023, the parties reached a settlement, thereby concluding the matter. – Juluca On 12 June 2020, Cipla sent ViiV Healthcare a paragraph IV letter related to Juluca, and on 22 July 2020, ViiV Healthcare filed suit against Cipla in federal court in Delaware. In March 2023, the parties reached a settlement, thereby concluding the matter. RSV On 7 June 2022, Pfizer, Inc. filed suit in the London High Court challenging the validity and requesting revocation of three GSK European patents relating to RSV vaccine technology. Corresponding invalidity suits against additional patents were filed in the District Court of the Hague in the Netherlands in January 2023 and in the French-speaking Enterprise Court of Brussels in Belgium in March 2023. In each of those matters GSK counterclaimed that Pfizer’s RSV vaccine infringes GSK’s patents. On 2 August 2023, GSK filed a patent infringement suit against Pfizer in the United States District Court for the District of Delaware alleging infringement of four US GSK patents by Pfizer’s RSV vaccine, Abrysvo. Another two GSK patents were added to the US litigation on 30 November 2023. The trial in the UK action took place in June 2023. A decision is expected by the end of Q2 2024. In the Netherlands, two separate first-instance hearings have been scheduled. The first was held on 26 January 2024 and the second is scheduled for 1 March 2024. In Belgium, trial on the merits is expected in Q3 2024 with a first instance decision likely in Q1 2025. A trial date in the US has yet to be set. GSK is seeking monetary compensation from Pfizer for Pfizer’s infringing sales of Abrysvo. GSK’s sales of Arexvy are not at issue in these litigations. 263 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 47. Legal proceedings continued Product liability The Group is currently a defendant in a number of product liability lawsuits. Avandia There are two pending US class actions (both filed in 2010) by third-party payers which assert claims under the Racketeer Influenced and Corrupt Organizations Act (RICO) and state consumer protection laws. In December 2019, the Third Circuit Court of Appeals reversed the summary judgements granted in favour of the Group and remanded the third-party payer cases back to district court. Discovery is complete, and class certification and summary judgment briefing has been completed. A hearing on certain Daubert motions relating to experts was held on 1 February 2024. GSK has requested oral argument on class certification, which could be scheduled thereafter. Zantac In 2019, the Group was contacted by several regulatory authorities regarding the detection of N-Nitroso-dimethylamine (NDMA) in Zantac (ranitidine) products. Based on information available at the time and correspondence with regulators, the Group made the decision to suspend the release, distribution and supply of all dose forms of Zantac to all markets pending the outcome of the ongoing tests and investigations. Also, as a precautionary action, the Group made the decision to initiate a voluntary pharmacy/retail level recall of Zantac products globally. On 30 April 2020, the European Medicines Agency (EMA) recommended the suspension of ranitidine medicines. Following the publication of the EMA’s recommendation, the Company communicated a decision not to re-enter the market. In the US, FDA requested that all manufacturers withdraw ranitidine products from the market. The Group was named as a defendant in approximately 2,200 personal injury cases filed in the federal Zantac Multidistrict Litigation (MDL) court proceeding in the Southern District of Florida. In the MDL, plaintiffs originally identified 10 different types of cancers they wished to pursue. Plaintiffs subsequently dropped 5 of the 10 cancers, and proceeded only as to bladder, esophageal, stomach, liver, and pancreatic cancers, although plaintiffs in state courts continue to pursue claims beyond the 5 designated cancers. On 6 December 2022, the court presiding over the federal MDL proceeding granted Defendants’ Daubert motions, finding that Plaintiffs’ experts’ causation opinions regarding whether Zantac can cause the five cancers at issue in the MDL (liver, bladder, pancreatic, esophageal, and stomach) are unreliable and thus inadmissible. Without expert causation opinions, the MDL Court granted summary judgment to GSK and the other brand defendants. The MDL Court found that “there is no scientist outside this litigation who concluded ranitidine causes cancer, and the plaintiffs’ scientists within this litigation systemically utilized unreliable methodologies,” and failed to use “consistent, objective, science-based standards for the even-handed evaluation of data.” This ruling effectively dismissed approximately 2,200 filed cases in the MDL and is binding on all of the claims in the Census Registry. Approximately 13,000 Plaintiffs (which includes plaintiffs with filed cases and registry claimants) have appealed the MDL decision to the Eleventh Circuit Court of Appeals. Plaintiffs’ briefs are due on 10 April 2024. Following the Court’s Daubert decision, it entered a final order dismissing the medical monitoring and consumer class actions based on the reasoning in its Daubert holding. Plaintiffs have filed a notice of appeal in the medical monitoring and consumer class action cases. GSK has been named as a defendant by approximately 78,000 plaintiffs in several US state jurisdictions. Of these plaintiffs, approximately 72,000 plaintiffs filed in Delaware. Most of the Delaware plaintiffs allege a cancer other than the five cancers being pursued by Plaintiffs in the MDL proceeding. The Delaware court held a general causation hearing on the admissibility of expert testimony for the 10 cancers Plaintiffs have decided to pursue (breast, colorectal, kidney, prostate, pancreatic, lung, bladder, liver, esophageal, and stomach) on 22-24 January 2024. In the California Zantac litigation Cases JCCP 5150 (JCCP), the court issued a Sargon ruling in the first case scheduled for trial (Goetz). The court found that the plaintiff’s experts’ causation opinions are admissible and can be presented to a jury. The ruling applied only to the Goetz case and does not affect any other state court cases. On 23 June 2023, GSK reached a confidential settlement in the Goetz case. On 11 October 2023, GSK announced it had reached confidential settlements in the Cantlay/Harper case as well as the three remaining breast cancer bellwether cases in California. On 1 February 2024, GSK announced it had reached a confidential settlement in the Browne case filed in California state court. The case, which was set to begin trial on 20 February 2024, will be dismissed. The settlements reflect GSK’s desire to avoid the distraction related to protracted litigation. GSK does not admit any liability in the settlements and will continue to vigorously defend itself based on the facts and the science in all other Zantac cases. The next case scheduled for trial in the JCCP is Boyd (colorectal). The Court has set a Sargon hearing for 29 February 2024 and a trial date of 2 April 2024. Additional bellwether cases in the JCCP have been and will be set for trial in Q2 and Q3 2024. Multiple trials in other state courts have been set with dates in 2024 and 2025, including in Illinois, Texas, and Florida. The first of these cases is Valadez (colorectal) which is scheduled for trial on 25 April 2024. There are 14 additional cases in Illinois with trial dates in 2024 and 2025. Cases in Texas and Florida do not yet have firm trial dates, although trials are expected to occur in 2024 and 2025. Outside the US, there are two proposed class actions pending against GSK in Ontario and Quebec, Canada along with a class action in Israel. In Canada, a certification hearing was held in October 2022 in the British Columbia proposed class action. This was the first class action to proceed to a certification hearing and the class action sought to certify a national class. In May 2023, the Court dismissed the proposed class action against the manufacturer defendants. An appeal from that decision was abandoned. The Ontario action will also be discontinued. There are also approximately 120 individual actions that have been filed in Canada. Given the complex ownership and marketing of Zantac prescription and over-the-counter (OTC) medicine over many years, numerous claims involve several defendants. As a result, some defendants have served one another, including the Group, with notice of potential indemnification claims about possible liabilities connected particularly with Zantac OTC. Given the current stage of the proceedings, the Group cannot meaningfully assess what liability, if any, it may have, nor can it meaningfully assess the liability of other parties under relevant indemnification provisions. 264 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 47. Legal proceedings continued In addition, on 20 March 2020, the Department of Justice (DOJ) sent the Group notice of a civil investigation it had opened into allegations of False Claims Act violations by the Group related to Zantac. On 18 June 2020, the DOJ served a Civil Investigative Demand (CID) on the Group, formalising its request for documents. The Group continues to cooperate with the DOJ on the CID. On the same day, the New Mexico Attorney General filed a lawsuit against multiple defendants, including the Group, alleging violations of state consumer protection and false advertising statutes, among other claims. On 11 November 2020, the Mayor & City of Baltimore filed an action against the Group alleging that Zantac increased the risk of cancer and/or caused cancer in Baltimore patients, and that the Group failed to warn of or concealed those risks. Fact and expert discovery is ongoing. The court has set a trial date of 2 June 2025. Zofran The Group was a defendant in over 400 product liability cases involving Zofran pending in a Multidistrict Litigation (MDL) proceeding in the District of Massachusetts. The cases alleged that children suffered birth defects due to their mothers’ ingestion of Zofran and/or generic ondansetron for pregnancy- related nausea and vomiting. Plaintiffs asserted that the Group sold Zofran knowing it was unsafe for pregnant women, failed to warn of the risks and illegally marketed Zofran “off-label” for use by pregnant women. On 1 June 2021, the MDL Court granted the Group’s motion for summary judgment on federal pre-emption grounds. The Court found that the FDA was fully informed of all relevant safety information regarding Zofran and had repeatedly rejected any attempt to add a birth defect warning to the label. At that time, the Court granted judgment for the Group in all cases pending in the MDL (approximately 431 cases) and closed the MDL proceeding. Plaintiffs appealed this decision and, on 9 January 2023, the United States Court of Appeals for the First Circuit affirmed the district court’s decision in favour of the Group. There remains one state court case and four proposed class actions in Canada, which are not currently active. Sales and marketing and regulation The Group’s marketing and promotion of its Pharmaceutical and Vaccine products are the subject of certain governmental investigations and private lawsuits brought by litigants under various theories of law. GSK Korea – Proceedings under Fair Trade Laws In August 2020, GSK Korea was indicted under Korea’s Monopoly Regulation and Fair Trade laws in relation to government tenders of HPV (Cervarix) and PCV (Synflorix) vaccines in 2018 and 2019. The prosecutor alleged that GSK Korea, through the actions of at least one of its employees, interfered with the tender process under the National Immunisation Programme by using “straw bidders.” A former GSK Korea employee was also charged in his individual capacity by the prosecutor in relation to the same matter. Further, a number of wholesalers are co-defendants in the proceedings. On 1 February 2023, the court rendered a guilty verdict in respect of all defendants. GSK Korea was fined KRW70 million which is approximately £45,000. Appeal proceedings are ongoing. The Korea Fair Trade Commission (KFTC) also commenced proceedings regarding the same matter. KFTC hearings took place in July 2023 and GSK Korea was found in violation of applicable fair trade law. The KFTC imposed a fine of KRW351 million which is approximately £212,000. US electronic health records subpoena On 19 March 2023, the Group received a subpoena from the United States Attorney’s Office for the Western District of Virginia, which is working with the United States Department of Justice Civil Division, seeking documents relating to the Group’s electronic health record programmes. The Group is cooperating with this enquiry. Senate HELP Enquiry The Group received a letter dated 8 January 2024 from majority members of the US Senate Health, Education, Labor and Pensions (“HELP”) Committee initiating an investigation into the pricing of inhalers for the treatment of asthma and COPD. The letter is similar to letters received by a number of other pharmaceutical companies and requests information on pricing, research in the treatment of respiratory diseases, patenting and business practices. The Group is cooperating with the enquiry. Orange Book Challenge In November 2023, the US Federal Trade Commission (FTC) wrote to the Group and identified five patents that it is challenging through an FDA Orange Book listing dispute process, reserving the right to take further action. A number of other companies were also contacted, with the FTC citing a total of 62 patents. As to the five patent listings challenged by the FTC, the Group has asked the FDA to remove four patents from the Orange Book with respect to certain products. It is the Group's position that these patents were properly listed at the time of the listing decision. No generic competition was impacted by the previous listings and all de-listed patents remain valid and enforceable. Subsequent to the FTC’s challenge, the Group received letters from US Senator Elizabeth Warren and US Congresswoman Pramila Jayapal, US Senator Amy Klobuchar, and US Senator Tammy Baldwin, reiterating the FTC position and requesting further information about the Group’s Orange Book-listed patents and the Group’s response to the FDA challenge process. The Group is cooperating with these enquiries. Anti-trust/competition Certain governmental actions and private lawsuits have been brought against the Group alleging violation of competition or anti-trust laws. Lamictal Purported classes of direct purchasers filed suit in the US District Court for the District of New Jersey alleging that the Group and Teva Pharmaceuticals unlawfully conspired to delay generic competition for Lamictal, resulting in overcharges to the purchasers, by entering into an allegedly anti-competitive reverse payment settlement to resolve patent infringement litigation. A separate count accuses the Group of monopolising the market. On 13 December 2018, the trial judge granted plaintiffs’ class certification motion, certifying a class of direct purchasers. The Group filed a Rule 23(f) motion in the Court of Appeals for the Third Circuit, challenging the class certification decision. On 22 April 2020, the Court of Appeals vacated the lower court’s grant of class certification and remanded the issue back to the lower court for further analysis. 265 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the financial statements continued 47. Legal proceedings continued On 9 October 2020, the district court heard argument on plaintiffs’ renewed motion for class certification after remand. On 9 April 2021, the district court denied Plaintiffs’ motion for class certification of the putative direct purchaser class, leaving a potential class of brand-only purchasers. Plaintiffs moved to supplement their expert report and seek additional discovery to support the addition of certain generic purchasers. On 21 January 2022, the district court denied Plaintiffs’ motion to supplement their expert report and seek additional discovery and held that the issue of generic purchasers had already been decided and denied in the court’s ruling on decertification. The parties conducted briefing on class certification as to the remaining brand-only purchasers, with plaintiffs also seeking to add a smaller category of purchasers. On 1 February 2023, the district court denied Plaintiffs’ renewed class certification motion. A series of follow-on complaints have been filed in the US District Court for the Eastern District of Pennsylvania by groups of alleged purchasers. The cases have been consolidated with the previously pending case in the District of New Jersey. Discovery is ongoing. Commercial and corporate The Group is involved in certain contractual and/or commercial disputes. 48. Post balance sheet events Zejula Royalty Dispute In October 2012, Tesaro, Inc. (now a wholly owned subsidiary of GSK) entered into two worldwide patent license agreements with AstraZeneca UK Limited related to niraparib (later approved as Zejula). In May 2021, AstraZeneca filed a lawsuit against Tesaro in the High Court, England and Wales alleging that Tesaro failed to pay some of the royalties due under the license agreements. Tesaro has counterclaimed based on a calculated overpayment. Trial was held the week of 6 March 2023 and judgment was entered against the Group on 5 April 2023, ruling that all current uses of Zejula generate royalty-bearing sales under the wording of the two license agreements. On 12 June 2023, the Court of Appeal of England and Wales granted the Group’s request for permission to appeal the 5 April 2023 judgment. The appeal was heard on 17 January 2024 and on 9 February 2024 the Court of Appeal ruled in the Group’s favour, overturning the trial court’s judgment and determining that only Zejula sales for uses falling within the licensed patents could be deemed royalty-bearing. The appropriate quantum of royalties in accord with the Court of Appeal’s judgment may be the subject of further proceedings. Acquisition of Aiolos Bio, Inc On 9 January 2024, GSK announced it had entered into an agreement to acquire Aiolos Bio, Inc, (Aiolos) a clinical stage biopharmaceutical company focused on addressing the unmet treatment needs of patients with certain respiratory and inflammatory conditions, for an upfront payment of US$1 billion and up to US$400 million in certain success-based regulatory milestone payments. In addition, GSK will also be responsible for success-based milestone payments as well as tiered royalties owed to Jiangsu Hengrui Pharmaceuticals Co., Ltd. (Hengrui). The transaction was subject to customary conditions, including applicable regulatory agency clearances under the Hart- Scott-Rodino Act in the US, and subsequently closed on 14 February 2024. Given the timing of the closure of the transaction, GSK expects to disclose the provisional accounting for the acquisition in the Q1 2024 Results Announcement. Disposal of shares in Haleon plc On 17 January 2024, GSK completed the sale of 300 million shares in Haleon plc equivalent to 3.2% of Haleon plc’s issued share capital at a price of 326 pence per share, raising gross proceeds of £978 million. Following the sale, GSK holds approximately 385 million ordinary shares in Haleon plc, representing over 4.0% of the issued share capital of Haleon plc. 266 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) as at 31 December 2023 Notes 2023 £m Fixed assets – investments Current assets: Trade and other receivables Cash at bank Total current assets Trade and other payables Total current liabilities Net current assets Total assets less current liabilities Provisions for liabilities Other non-current liabilities Net assets Capital and reserves Share capital Share premium account Other reserves Retained earnings: At 1 January Profit/(loss) for the year Ordinary shares issued under share option/award schemes Treasury shares transferred to the ESOP Trust Dividends in specie Dividends paid to shareholders Equity shareholders’ funds E F G H I J J K K 2023 £m 22,631 22,657 17 22,674 (740) (740) 21,934 44,565 (20) (388) 44,157 1,348 3,451 1,420 2022 £m 2022 £m 22,881 17,748 20 17,768 (545) (545) 17,223 40,104 (13) (645) 39,446 1,347 3,440 1,420 33,239 6,643 20 283 – (2,247) 50,596 710 – 1,089 (15,689) (3,467) 37,938 44,157 33,239 39,446 The financial statements on pages 267 to 271 were approved by the Board on 27 February 2024 and signed on its behalf by Sir Jonathan Symonds Chair GSK plc Registered number: 3888792 Company statement of changes in equity for the year ended 31 December 2023 At 1 January 2022 Profit and Total comprehensive income attributable to shareholders Treasury shares transferred to the ESOP Trust Dividends to shareholders (Note D) Dividends in specie (Note D) Shares issued under employee share schemes At 31 December 2022 Profit and Total comprehensive income attributable to shareholders Treasury shares transferred to the ESOP Trust Dividends to shareholders (Note D) Shares issued under employee share schemes At 31 December 2023 Share capital £m 1,347 – – – – – 1,347 – – – 1 Share premium account £m 3,301 – – – – 139 3,440 – – – 11 Other reserves £m Retained earnings £m Total equity £m 1,420 50,596 56,664 – – – – – 710 1,089 710 1,089 (3,467) (3,467) (15,689) (15,689) – 139 1,420 33,239 39,446 – – – – 6,643 283 6,643 283 (2,247) (2,247) 20 32 1,348 3,451 1,420 37,938 44,157 267 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) A) Presentation of the financial statements Description of business GSK Plc is the parent company of GSK, a major global biopharma group which prevents and treats disease with vaccines, specialty and general medicines. GSK focuses on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas: infectious diseases, HIV, respiratory/immunology and oncology. Preparation of financial statements The financial statements, which are prepared using the historical cost convention (as modified to include the revaluation of certain financial instruments) and on a going concern basis, are prepared in accordance with Financial Reporting Standard 101 ‘Reduced Disclosure Framework’ and with UK accounting presentation and the Companies Act 2006 as at 31 December 2023, with comparative figures as at 31 December 2022 As permitted by section 408 of the Companies Act 2006, the income statement of the company is not presented in this Annual Report. Key accounting judgements and estimates No key accounting judgements or estimates were required in the current year. B) Accounting policies Foreign currency transactions Foreign currency transactions are recorded at the exchange rate ruling on the date of transaction. Foreign currency assets and liabilities are translated at rates of exchange ruling at the balance sheet date. Dividends paid and received Dividends paid and received are included in the financial statements in the period in which the related dividends are actually paid or received. Expenditure Expenditure is recognised in respect of goods and services received when supplied in accordance with contractual terms. Provision is made when an obligation exists for a future liability in respect of a past event and where the amount of the obligation can be reliably estimated. The company is included in the Group financial statements of GSK plc, which are publicly available. The following exemptions from the requirements of IFRS have been applied in the preparation of these financial statements, in accordance with FRS 101: Investments in subsidiary companies Investments in subsidiary companies are held at cost less any provision for impairment and also includes a capital contribution in relation to movements in contingent consideration. – Paragraphs 45(b) and 46 to 52 of IFRS 2, ‘Share-based payment’ – IFRS 7, ‘Financial Instruments – Disclosures’ – Paragraphs 91-99 of IFRS 13, ‘Fair value measurement’ – Paragraph 38 of IAS 1, ‘Presentation of financial statements’ comparative information requirements in respect of paragraph 79(a) (iv) of IAS 1 – Paragraphs 10(d), 10(f), 16, 38(A), 38 (B to D), 40 (A to D), 111 and 134 to 136 of IAS 1, ‘Presentation of financial statements’ – IAS 7, ‘Statement of cash flows’ – Paragraph 30 and 31 of IAS 8, ‘Accounting policies, changes in accounting estimates and errors’ – Paragraph 17 of IAS 24, ‘Related party disclosures’ and the further requirement in IAS 24 to disclose related party transactions entered into between two or more members of a Group. Accounting convention and standards The balance sheet has been prepared using the historical cost convention and complies with applicable UK accounting standards. Accounting principles and policies The preparation of the balance sheet in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the balance sheet. Actual amounts could differ from those estimates. The balance sheet has been prepared in accordance with the company’s accounting policies approved by the Board and described in Note B. These policies have been consistently applied, unless otherwise stated. Impairment of investments The carrying value of investments are reviewed for impairment when there is an indication that the investment might be impaired. The assessment method used is to compare the carrying value of each investment against its share of the net assets value of the investment or against its share of the valuation of the subsidiary based on expected discounted cash flows. Any impairment charge is recognised in the income statement in the year concerned. Assets held for sale/distribution Non-current assets are held for disposal/demerger only if available for immediate disposal/demerger in their present condition, a disposal/demerger is highly probable and expected to be completed within one year from the date of classification. Such assets are measured at the lower of carrying value and fair value less the cost of disposal. Trade and other receivables Trade and other receivables are carried at amortised cost less allowance of expected credit losses. Expected credit losses are calculated in accordance with the approach permitted by IFRS 9. The majority of the balance within trade and other receivables is amounts owed by Group undertakings. The Company applies a general approach to calculate the expected credit losses. If a receivable is determined to be non- collectable it is written off, firstly against any expected credit loss allowance available and then to the statement of comprehensive income. Subsequent recoveries of amounts previously provided for are credited to the statement of comprehensive income. Long term receivables are discounted where the effect is material. Share-based payments The company issues shares to employees on behalf of its subsidiary companies for cash consideration. 268 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) Treasury shares The purchase price paid for the treasury shares is included within retained earnings. Treasury shares are transferred to the ESOP trust at the fair market price at the date of the transfer for cash consideration. If the proceeds are equal to or less than the purchase price paid by the company for the shares, the proceeds are treated as a realised loss. If the proceeds exceed the purchase price, the excess over the purchase price is transferred to the share premium account. The purchase price paid by the company for the shares is determined by the use of a weighted average price method. Taxation Current tax is provided at the amounts expected to be paid applying tax rates that have been enacted or substantively enacted by the balance sheet date. Deferred tax is provided in full, using the liability method, on temporary differences arising between the tax bases of assets and liabilities and their carrying amounts in the financial statements. Deferred tax assets are only recognised to the extent that they are considered recoverable against future taxable profits. Deferred tax is measured at the average tax rates that are expected to apply in the periods in which the temporary differences are expected to be realised or settled. Deferred tax liabilities and assets are not discounted. Financial guarantees Liabilities relating to guarantees issued by the company on behalf of its subsidiaries are initially recognised at fair value and subsequently measured at the higher of: 1. the Expected Credit Loss (ECL) measured used the general approach; and 2. the amount initially recorded less, when appropriate, accumulated amortisation. C) Operating profit A fee of £14,752 (2022: £12,600) relating to the audit of the company has been charged in operating profit. D) Dividends In 2023 the Directors declared four interim dividends resulting in a dividend for the year of 58.00 pence. For further details, see Note 16 'Dividends' to the Group financial statements. The demerger of the Consumer Healthcare business was implemented by GSK declaring an interim dividend in July 2022 as follows. Dividend in specie of Haleon plc shares distributed to external shareholders Dividend in specie of Haleon plc shares distributed to the ESOP Trusts E) Fixed assets – investments Shares in GlaxoSmithKline Services Unlimited Shares in GlaxoSmithKline Holdings (One) Limited Shares in GlaxoSmithKline Holdings Limited Shares in GlaxoSmithKline Mercury Limited Shares in GSK LP Limited Capital contribution relating to share-based payments Contribution relating to contingent consideration 2022 £m 15,526 163 15,689 2022 £m 637 18 2023 £m 654 18 17,888 17,888 33 2,476 21,069 1,139 423 33 2,493 21,069 1,139 673 22,631 22,881 269 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) F) Trade and other receivables Amounts due within one year: Other debtors Amounts owed by Group undertakings Amounts due after more than one year: Amounts owed by Group undertakings 2023 £m 2022 £m 1 22,367 22,368 289 22,657 2 17,422 17,424 324 17,748 The amounts owed by Group undertakings due within one year primarily include a call account balance with GSK Finance plc which is unsecured, repayable on demand with interest received at SONIA rate less 0.05% per annum (2022: SONIA rate less 0.05%). The directors consider that the carrying amount of amounts owed by Group undertakings approximates to their fair values. No provision for expected credit loss has been recognised as the counter-party has access to sufficient funds and assets to fulfil its future obligations. Amounts owed by Group undertakings are not past due and no increased credit risk experienced since initial recognition. The movement in the Amounts owed by Group undertakings in the period, as reflected within Notes F and G, primarily reflects the receipt of dividend income from subsidiaries and utilisation of the company’s current account to fund the payment of interim dividends. G) Trade and other payables Amounts due within one year: Other creditors Contingent consideration payable Corporation tax Amounts owed to Group undertakings 2023 £m 349 35 201 155 740 2022 £m 396 28 18 103 545 The company has guaranteed debt issued by certain subsidiary companies and for which it receives an annual fee from one of the subsidiaries. In aggregate, the company has outstanding guarantees over £16.5 billion of debt instruments (2022: £19.5 billion). The financial guarantee contract liability of £327 million (2022: £371 million) is included within other creditors. The amounts due from the subsidiary company in relation to these guarantee fees will be recovered over the life of the bonds and are disclosed within ‘Trade and other receivables’ (see Note F). H) Provisions for liabilities At 1 January Charge for the year Utilised At 31 December The provisions relate to a number of legal and other disputes in which the company is currently involved. I) Other non-current liabilities Contingent consideration payable 2023 £m 13 28 (21) 20 2022 £m 12 43 (42) 13 2023 £m 388 2022 £m 645 The contingent consideration relates to the amount payable for the acquisition in 2015 of the Novartis Vaccines portfolio. The current year liability is included within ‘Trade and other payables’. For further details, see Note 33 'Contingent consideration liabilities' to the Group financial statements. 270 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) J) Share capital and share premium account Share capital issued and fully paid 1 January 2022 Impact of share consolidation Issued under employee share schemes Ordinary shares acquired by ESOP Trust At 31 December 2022 Issued under employee share schemes Ordinary shares acquired by ESOP Trust At 31 December 2023 Ordinary shares Share premium account Number £m £m 5,387,015,059 1,347 3,301 (1,077,403,011) 1,731,293 – – – – – 25 114 4,311,343,341 1,347 3,440 802,642 – 1 – 9 2 4,312,145,983 1,348 3,451 At 31 December 2023, of the issued share capital, 58,817,197 shares were held in the ESOP Trusts (out of which 58,493,518 were held for future exercise of share options and share awards and 323,679 shares were held for the Executive Supplemental Savings Plan), 197,068,169 shares were held as Treasury shares and 4,056,260,617 shares were in free issue. All issued shares are fully paid and there are no shares authorised but not in issue. The nominal, carrying and market values of the shares held in the ESOP Trusts are disclosed in Note 45, ‘Employee share schemes’. K) Retained earnings and other reserves The profit of GSK plc for the year was £6,643 million (2022: £710 million). After dividends paid of £2,247 million (2022: £19,156 million which included the Consumer Healthcare business demerger dividend of £15,689 million), and the effect of £283 million Treasury shares transferred to a subsidiary company (2022: £1,089 million) retained earnings at 31 December 2023 stood at £37,938 million (2022: £33,239 million), of which £12,938 million is not considered by the Company to be available for distribution (2022: £8,140 million). Dividends to shareholders are paid out of the reserves of the Company considered to be available of distribution, which at 31 December 2023 amounted to £25,000 million (2022: £25,099 million). Other reserves includes a capital redemption reserve and a reserve reflecting historical contributions of shares in the company which were issued to satisfy share option awards granted to employees of subsidiary companies. L) Group companies See pages 306 to 314 for a complete list of subsidiaries, associates, joint ventures and other significant shareholdings, which forms part of these financial statements. 271 Investor Information In this section Commercial Operations turnover Three year record Product development pipeline Products, competition and intellectual property Principal risks and uncertainties Share capital and control Dividends Financial calendar 2023 Annual General Meeting 2023 Tax information for shareholders Shareholder services and contacts US law and regulation Group companies Glossary of terms 273 275 277 281 284 295 297 298 298 299 301 303 306 315 GSK Annual Report 2023 272 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Financial record Commercial Operations turnover by therapeutic area 2023 Total US 2023 Growth 2023 Growth 2023 Europe Growth International 2023 Growth Shingles Shingrix Meningitis Bexsero Menveo Other RSV Arexvy Influenza Fluarix/FluLaval Established Vaccines Infanrix, Pediarix Boostrix Hepatitis Rotarix Synflorix Priorix, Priorix Tetra, Varilrix Cervarix Others Vaccines ex COVID Pandemic vaccines Pandemic adjuvant Vaccines HIV Dolutegravir products Tivicay Triumeq Juluca Dovato Rukobia Cabenuva Apretude Others Respiratory/Immunology and Other Nucala Benlysta Other Oncology Zejula Blenrep Jemperli Ojjaara Other Specialty Medicines ex COVID Pandemic Xevudy Specialty Medicines Respiratory Arnuity Ellipta Anoro Ellipta Avamys/Veramyst Flixotide/Flovent Incruse Ellipta Relvar/Breo Ellipta Seretide/Advair Trelegy Ellipta Ventolin Other Respiratory Other General Medicines Dermatology Augmentin Avodart Lamictal Other General Medicines Total Commercial Operations £% CER% 17 16 17 16 14 13 14 13 12 10 67 72 – – – – (29) (29) (29) (29) 7 6 (6) (7) 4 3 8 7 18 17 (10) (10) 41 41 5 3 11 13 24 23 >100 >100 >100 >100 25 24 13 12 5 4 2 – (14) (14) 4 4 33 32 44 43 >100 >100 >100 >100 £m 1,880 1,880 610 311 299 – 1,194 1,194 371 371 1,254 291 394 336 192 – 16 – 25 5,309 – – 5,309 4,283 3,418 801 1,074 511 1,032 110 587 149 19 2,100 978 1,121 1 396 257 £m 3,446 3,446 1,260 849 380 31 1,238 1,238 504 504 3,266 554 614 611 614 275 265 120 213 9,714 150 150 9,864 6,444 5,408 1,386 1,542 661 1,819 117 708 149 62 3,025 1,655 1,349 21 731 523 36 >100 141 33 – (2) >(100) 14 (98) (98) (9) 4 (36) 15 (7) (17) (17) (4) (2) 27 (3) (11) (5) (3) 9 5 (15) (9) 1 3 10,200 44 44 10,244 6,825 36 557 299 451 162 1,103 1,139 2,202 749 127 3,395 363 628 345 435 1,624 10,220 30,328 (35) 16 16 18 (48) 21 13 (69) (33) 18 18 19 (42) 23 15 (69) >100 – >(100) 15 (98) (98) (8) 6 (34) 16 (4) (16) (17) (2) 1 29 – (5) 2 4 17 7 (13) 1 5 5 (39) 15 11 18 – 27 9 (2) >(100) >100 – – 15 (99) (99) 1 7 (40) 15 – (20) (25) (12) 11 28 (3) (100) (23) – – – (27) (13) 4 9 108 33 – 6,779 10 10 6,789 3,442 29 269 – 283 78 436 341 1,606 400 – 280 – – – 194 86 3,722 15,820 £% CER% (4) (4) (4) (4) 6 7 (6) (7) 25 25 – – – – – – (32) (32) (32) (32) 9 8 (11) (11) 10 9 (1) (2) >100 – 60 – 14 25 – – 25 14 3 (3) (12) 3 33 39 100 >100 >100 – 60 – 9 26 – – 26 14 4 (2) (11) 4 33 41 >100 >100 (42) 15 11 19 – 27 10 >(100) >100 – – 15 (99) (99) 1 8 (40) 16 – (20) (24) (12) 11 29 (2) (100) (22) – – – (27) (11) 5 9 £m 908 908 433 417 12 4 4 4 39 39 742 121 122 177 118 36 129 33 6 2,126 130 130 2,256 1,423 1,290 267 280 136 607 7 103 – 23 468 383 99 (14) 289 222 38 31 – (2) 2,180 3 3 2,183 1,402 – 193 57 70 59 366 256 275 100 26 723 107 186 109 111 210 2,125 6,564 £% CER% 30 32 30 32 17 20 21 24 (45) (40) (20) (20) – – – – (33) (32) (33) (32) 2 3 (8) (8) (13) (12) 23 25 (5) (3) 3 6 30 33 45 50 (76) (82) 15 16 >100 >100 >100 >100 18 20 7 9 3 4 (4) (2) (24) (22) 6 7 25 27 >100 >100 >100 >100 – – (25) (18) 26 28 26 28 18 19 12 18 13 14 12 14 (27) (27) >100 – (100) 13 (99) (99) (8) 1 – 17 (12) (5) (8) 5 (11) 17 (14) (13) 4 – 23 2 2 (5) 2 3 >100 – – 11 (99) (99) (10) – – 15 (14) (5) (9) 4 (12) 16 (16) (17) 2 (1) 21 (1) 1 (7) 1 2 £m 658 658 217 121 69 27 40 40 94 94 1,270 142 98 98 304 239 120 87 182 2,279 20 20 2,299 738 700 318 188 14 180 – 18 – 20 457 294 129 34 46 44 – 2 – – 1,241 31 31 1,272 1,981 7 95 242 98 25 301 542 321 249 101 2,392 256 442 236 130 1,328 4,373 7,944 £% CER% >100 >100 29 61 (13) >100 >100 20 46 (19) >100 – – (13) (13) 5 4 2 14 (2) (12) 48 (8) 37 26 >100 >100 27 8 9 12 (15) (7) 50 – >100 – (44) 11 21 13 (40) 28 29 – >100 – >(100) 10 (97) (97) (41) 1 (13) 12 (5) (17) (11) – (4) 34 2 (10) (5) (5) 4 6 (5) (9) (2) (6) >100 – – (10) (10) 7 10 4 17 2 (12) 53 (4) 34 31 >100 >100 31 16 17 21 (11) (7) 59 – >100 – (31) 21 33 25 (33) 61 65 – >100 – (100) 19 (97) (97) (36) 9 – 20 (2) (11) (7) 8 3 44 11 (1) 6 6 16 10 4 3 7 1 273 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Financial record continued Commercial Operations turnover by therapeutic area 2022 Shingles Shingrix Meningitis Bexsero Menveo Other Influenza Fluarix/Flulaval Established vaccines Infanrix, Pediarix Boostrix Hepatitis Rotarix Synflorix Priorix, Priorix Tetra, Varilrix Cervarix Others Vaccines ex COVID Pandemic vaccines Pandemic adjuvant Vaccines HIV Dolutegravir products Tivicay Triumeq Juluca Dovato Rukobia Cabenuva Apretude Others Respiratory/Immunology and Other Nucala Benlysta Other Oncology Zejula Blenrep Jemperli Other Specialty Medicines ex COVID Pandemic Xevudy Specialty Medicines Respiratory Arnuity Ellipta Anoro Ellipta Avamys/Veramyst Flixotide/Flovent Incruse Ellipta Relvar/Breo Ellipta Seretide/Advair Trelegy Ellipta Ventolin Other Respiratory Other General Medicines Dermatology Augmentin Avodart Lamictal Other General Medicines Total Commercial Operations 2022 £m 2,958 2,958 1,116 753 345 18 714 714 3,085 594 594 571 527 305 188 117 189 7,873 64 64 7,937 5,749 5,191 1,381 1,799 636 1,375 82 340 41 95 2,609 1,423 1,146 40 602 463 118 21 – 8,960 2,309 2,309 11,269 6,548 56 483 321 545 196 1,145 1,159 1,729 771 143 3,570 376 576 330 511 1,777 10,118 29,324 Total Growth 2022 Growth 2022 US Europe Growth 2022 £% CER% £% CER% 60 72 60 72 11 16 12 16 18 27 (54) (54) (4) 5 (4) 5 – 4 3 9 7 14 16 24 (3) (3) (15) (15) (29) (28) (20) (15) 26 26 17 24 (86) (86) (86) (86) 11 17 12 20 6 14 (7) – (11) (4) 14 23 65 75 64 82 >100 >100 – – (29) (25) 20 29 18 25 20 31 >100 >100 17 23 12 17 25 33 >100 >100 – – 15 23 >100 >100 >100 >100 29 37 3 8 9 19 (9) (4) 6 8 15 23 (10) (4) (2) 2 (17) (15) 32 42 2 7 6 4 (2) (1) (5) (6) 38 35 (3) (1) 1 7 (10) (10) 1 5 13 19 £m 1,964 1,964 573 333 240 – 549 549 1,157 327 360 343 95 – 10 – 22 4,243 – – 4,243 3,756 3,311 823 1,217 494 777 79 294 41 31 1,830 881 949 – 313 235 66 13 (1) 5,899 828 828 6,727 3,209 48 233 – 353 104 498 308 1,253 411 1 363 (1) – – 265 99 3,572 14,542 £% CER% 32 46 32 46 14 26 19 32 8 20 – – 9 20 9 20 18 7 (3) 8 20 33 15 28 (23) (14) – – – – – – (17) (8) 18 31 (100) (100) (100) (100) 10 22 17 30 19 8 (3) 8 (8) 2 13 26 64 82 65 84 >100 >100 – – (45) (37) 16 29 15 28 18 31 – – 3 14 – 11 8 (3) >100 – 29 38 38 30 10 20 (16) – 28 (5) 2 (37) 47 5 – 10 – – – 14 – 10 22 >100 – 16 24 24 17 (1) 10 (24) – 16 (14) (8) (43) 32 (5) – (1) – – – 3 (9) (1) 10 £m 688 688 362 337 20 5 57 57 720 131 138 142 122 34 97 22 34 1,827 57 57 1,884 1,310 1,239 273 361 127 478 3 40 – 28 366 300 83 (17) 253 194 52 8 (1) 1,929 456 456 2,385 1,384 – 165 65 74 64 347 287 236 116 30 695 107 151 107 109 221 2,079 6,348 >100 >100 2 3 (5) – (44) (44) 3 13 (1) 30 3 (24) (22) (12) 55 27 – – 31 10 8 (5) (20) 14 58 50 >100 – (22) 13 17 22 – 30 19 86 >100 – 13 >100 >100 34 3 – 11 – 7 (9) 4 (11) 18 7 11 (14) (18) 22 (9) (3) (31) (3) 18 >100 >100 3 4 (10) – (44) (44) 4 13 (1) 31 5 (22) (22) (8) 45 28 – – 32 10 8 (4) (19) 15 59 50 >100 – (22) 13 17 22 – 31 20 86 >100 – 13 £m 306 306 181 83 85 13 108 108 1,208 136 96 86 310 271 81 95 133 1,803 7 7 1,810 683 641 285 221 15 120 – 6 – 36 413 242 114 57 36 34 – – 2 1,132 >100 1,025 1,025 >100 2,157 35 1,955 3 8 – 85 11 256 2 118 7 28 (7) 300 4 564 (11) 240 19 244 8 112 7 2,512 (13) 270 (18) 425 23 223 (8) 137 (3) 1,457 (31) 4,467 (3) 8,434 19 International Growth £% CER% >100 >100 20 23 71 (62) (16) (16) 8 6 (15) (1) 1 (14) (43) (22) 32 6 (97) (97) (5) (3) (3) (19) (9) 8 >100 – >100 – (17) 47 28 43 >100 75 75 – – – 13 >100 >100 70 9 – 10 8 16 – 2 1 48 10 5 2 1 44 – – (6) 5 14 >100 >100 18 20 67 (62) (11) (11) (7) 10 (14) 5 (1) (13) (40) (16) 28 8 (97) (97) (3) – – (14) (8) 15 >100 – >100 – (14) 45 24 44 >100 80 70 – – – 14 >100 >100 69 10 14 10 10 18 8 – 3 47 11 2 1 – 41 5 2 (7) 5 14 274 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Financial record continued Three-year selected financial data A record of financial performance is provided, analysed in accordance with current reporting practice. The information included in the selected financial data (except for number of employees and adjusted results) is prepared in accordance with International Accounting Standards in conformity with the requirements of the Companies Act 2006 and also with IFRS as issued by the International Accounting Standards Board. Group turnover by geographic region US Europe International Group turnover by product group Vaccines Specialty Medicines General Medicines Vaccines turnover Shingles Meningitis RSV Influenza Established Vaccines Pandemic Vaccines Specialty Medicines turnover HIV Respiratory/Immunology and other Oncology Pandemic General Medicines Respiratory Other General Medicines Financial results – Total Turnover Profit after taxation from continuing operations Profit after taxation from discontinued operations and other gains/(losses) from the demerger Remeasurement of discontinued operations distributed to shareholders on demerger Profit after taxation from discontinued operations Profit after taxation for the year Basic earnings per share from continuing operations Basic earnings per share from discontinued operations Total basic earnings per share Diluted earnings per share from continuing operations Diluted earnings per share from discontinued operations Total diluted earnings per share 2023 £m 15,820 6,564 7,944 2022 £m 14,542 6,348 8,434 2021 £m 11,914 5,370 7,412 30,328 29,324 24,696 2023 £m 9,864 10,244 10,220 30,328 2023 £m 3,446 1,260 1,238 504 3,266 150 9,864 2023 £m 6,444 3,025 731 44 10,244 2023 £m 6,825 3,395 10,220 2023 £m 30,328 5,308 – – – 5,308 pence 121.6p – 121.6p 119.9p – 119.9p 2022 £m 7,937 11,269 10,118 2021 £m 6,778 8,251 9,667 29,324 24,696 2022 £m 2,958 1,116 – 714 3,085 64 7,937 2022 £m 5,749 2,609 602 2,309 11,269 2022 £m 6,548 3,570 10,118 2022 £m 29,324 4,921 3,049 7,651 10,700 15,621 pence 110.8p 260.6p 371.4p 109.2p 257.0p 366.2p 2021 £m 1,721 961 – 679 2,970 447 6,778 2021 £m 4,777 2,027 489 958 8,251 2021 £m 6,048 3,619 9,667 2021 £m 24,696 3,516 1,580 – 1,580 5,096 pence 82.9p 26.7p 109.6p 81.8p 26.4p 108.2p 275 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Financial record continued Three-year selected financial data continued Financial results – Adjusted Turnover Continuing operating profit Continuing profit before taxation Continuing profit after taxation 2023 £m 30,328 8,786 8,112 6,855 2022 £m 29,324 8,151 7,358 6,220 2021 £m 24,696 6,493 5,774 4,856 2021 £m 4,357 761 347 424 1,143 (539) 6,493 pence 82.9p 15.2p 6.6p 8.7p 18.1p (21.2)p 110.3p The reconciliation between Total and Adjusted operating profit over the last three years can be summarised as follows: Total continuing operating profit Intangible asset amortisation Intangible asset impairment Major restructuring Transaction-related items Divestments, significant legal and other items Adjusted continuing operating profit 2023 £m 6,745 719 398 382 572 (30) 8,786 2022 £m 6,433 739 296 321 1,750 (1,388) 8,151 The reconciliation between total and Adjusted earnings per share over the last three years can be summarised as follows: Total continuing earnings per share Intangible asset amortisation Intangible asset impairment Major restructuring Transaction-related items Divestments, significant legal and other items Adjusted continuing earnings per share Return on capital employed pence 121.6p 13.9p 7.5p 7.4p 6.9p (2.2) p 155.1p % 53.0 pence 110.8p 14.6p 5.8p 5.9p 34.1p (31.5)p 139.7p % n/m % 25.8 For 2021 and 2023 return on capital employed is calculated as total profit before taxation as a percentage of average net assets over the year and is not restated. Return on capital employed is not calculated for 2022 as it is not meaningful (n/m) as the average net assets over the year included Consumer Healthcare which was demerged on 18 July 2022. Balance sheet Non-current assets Current assets Total assets Current liabilities Non-current liabilities Total liabilities Net assets Shareholders’ equity Non-controlling interests Total equity Number of employees US Europe International Manufacturing Selling Administration Research and development 2023 40,361 18,644 59,005 2022 39,377 20,769 60,146 2021 60,429 18,674 79,103 (21,068) (25,142) (46,210) (22,810) (27,240) (50,050) (23,670) (34,091) (57,761) 12,795 10,096 21,342 13,347 (552) 12,795 10,598 (502) 10,096 2023 12,205 32,675 25,332 70,212 23,159 26,193 7,888 12,972 70,212 2022 11,946 31,800 25,654 69,400 23,292 26,310 7,605 12,193 69,400 15,055 6,287 21,342 2021 14,289 38,809 36,998 90,096 32,141 34,846 11,014 12,095 90,096 The geographic distribution of employees in the table above is based on the location of GSK’s subsidiary companies. The number of employees is the number of permanent employed staff at the end of the financial period. It excludes those employees who are employed and managed by GSK on a contract basis. 276 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition Pharmaceuticals and Vaccines product development pipeline Key † ^ In-license or other alliance relationship with third party ViiV Healthcare, a global specialist HIV company with GSK, Pfizer, Inc. and Shionogi Limited as shareholders, is responsible for developing and delivering HIV medicines BLA MAA NDA Biological Licence Application Marketing Authorisation Application (Europe) New Drug Application (US) A S Approved Submitted Phase I Evaluation of clinical pharmacology, usually conducted in volunteers Phase II Determination of dose and initial evaluation of efficacy, conducted in a small number of patients Phase III Large comparative study (compound versus placebo and/or established treatment) in patients to establish clinical benefit and safety MAA and NDA/BLA regulatory review milestones shown in the table below are those that have been achieved. Future filing dates are not included in this list. Mechanism of Action/Vaccine Type Indication Phase MAA NDA/BLA JAK1, JAK2 and ACVR1 inhibitor Myelofibrosis Approved A:Jan24 A:Sep23 Achieved regulatory review milestones Compound Oncology Ojjaara/Omjjara (momelotinib)† Jemperli (dostarlimab)† Anti-Programmed Cell Death protein 1 receptor (PD-1) antibody Zejula (niraparib)† Poly (ADP-ribose) polymerase (PARP) 1/2 inhibitor Blenrep (belantamab mafodotin)† ADC targeting B-cell maturation antigen dMMR/MSI-H 1L endometrial cancer 1L endometrial cancer combination with Zejula (niraparib) Peri-operative dMMR/MSI-H colon cancer Non-small cell lung cancer1 Neoadjuvant dMMR/MSI-H rectal cancer 1L maintenance ovarian cancer combination with Jemperli (dostarlimab) 1L maintenance non small cell lung cancer (NSCLC) combination with pembrolizumab 2L+ multiple myeloma combination with Pomalyst and dexamethasone 2L+ multiple myeloma combination with Velcade and dexamethasone Multiple myeloma in combination with anti- cancer treatments (platform study) 1L multiple myeloma combination with Velcade, Revlimid and dexamethasone cobolimab† Anti-T-cell immunoglobulin and mucin domain-3 (TIM-3) antibody Non-small cell lung cancer combination with Jemperli (dostarlimab) and docetaxel belrestotug† Anti-TIGIT 4381562† 6097608† XMT-20562 (wholly owned by Mersana Therapeutics) Anti-PVRIG Anti-CD96 STING agonist ADC Non-small cell lung cancer combination with Jemperli (platform study) Squamous cell carcinoma of the head and neck combination with Jemperli and GSK6097608 (platform study) Cancer Cancer Cancer B-cell maturation antigen binder Multiple myeloma DNA polymerase theta inhibitor Cancer ADC targeting B7-H4 Gynecologic malignancies belantamab 4524101† 5733584† HIV^ Apretude (cabotegravir) 3810109† 3739937 4004280 4011499 4524184† HIV integrase strand transfer inhibitor (long-acting) HIV pre-exposure prophylaxis HIV infection Approved I A:Sep23 A:Dec21 HIV broadly neutralising antibody HIV infection HIV maturation inhibitor HIV capsid protein inhibitor HIV capsid protein inhibitor HIV integrase inhibitor HIV infection HIV infection HIV infection HIV infection II II II II II Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies. Footnotes (1) non-registrational. (2) GSK has an exclusive global license option to co-develop and commercialize the candidate. 277 Approved III A:Dec23 A:Jul23 III II II III III III III III II I III II II I I I I I I Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition continued Pharmaceuticals and Vaccines product development pipeline continued Compound Mechanism of Action/Vaccine Type Indication Phase MAA NDA/BLA Achieved regulatory review milestones Infectious Diseases Arexvy (RSV vaccine)† Recombinant protein, adjuvanted vaccine Respiratory syncytial virus prophylaxis in adults 60 years and older Respiratory syncytial virus prophylaxis in older adult population 50-59 years of age Approved A:Jun23 A:May23 Registration S:Jan24 S:Dec23 gepotidacin† bepirovirsen† Bexsero vaccine 3536819 (Men ABCWY vaccine) tebipenem pivoxil† ibrexafungerp† ganfeborole† alpibectir† 3437949† (Malaria fractional dose) 3536852† 3528869† (Therapeutic HBV) 4178116 (Varicella new strain) sanfetrinem cilexetil† 4106647† (HPV9-AS04) Triazaacenaphthylene bacterial type II topoisomerase inhibitor Uncomplicated urinary tract infection (uUTI) Urogenital gonorrhea (GC) HBV antisense oligonucleotide Chronic hepatitis B virus infection Recombinant protein and outer membrance vesicle vaccine Prevention of invasive disease caused by N. meninigitidis serogroup B in individuals 2 months of age and older (US) Recombinant protein, outer membrance vesicle, glycoconjugate vaccine Antibacterial carbapenem Prevention of invasive disease caused by N. meninigitidis serogroups A,B,C,W and Y in adolescents 10-25 years of age Complicated urinary tract infection (cUTI) Antifungal glucan synthase inhibitor Invasive candidiasis Leucyl t-RNA synthetase inhibitor Tuberculosis Ethionamide booster Tuberculosis Recombinant protein, adjuvanted vaccine Malaria prophylaxis (Plasmodium falciparum) Generalized Modules for Membrane Antigens (GMMA) vaccine Prime-boost with viral vector co- or sequentially administrated with adjuvanted recombinant proteins 4023393 (Men ABCWY, 2nd Gen) Recombinant protein, outer membrance vesicle – conjugated vaccine Live attenuated vaccine Serine beta lactamase inhibitor Tuberculosis Recombinant protein-adjuvanted vaccine Shigella diarrhea prophylaxis Treatment of chronic Hepatitis B infections – aims at functional cure by controlling and resolving the clinical sequelae of the infection and reducing the need for further treatment Prevention of invasive disease caused by N. meninigitidis serogroup A,B,C,W and Y in adolescents and children 6 weeks of age and older Active immunization for the prevention of varicella in individuals 12 months of age and older Active immunization of girls and women, boys and men (9-45 years), for the prevention of cancer, genital warts and precancerous or dysplastic lesions (girls, boys AIN only) caused by Human papillomavirus (HPV) Treatment of chronic Hepatitis B virus infection in individuals >18 years without decompensated cirrhosis 4388067 (CHBV ASO combo)† Targeted Immunotherapy (viral vector; adjuvanted recombinant proteins) & Direct Acting Antiviral (GSK's bepirovirsen) 5101955† MAPS Pneumococcal 24-valent paed Prevention of pneumonia and invasive pneumococcal disease caused by the Streptococcus pneumoniae 24 serotypes included in the vaccine in children aged 6 weeks – 17 years 5101956† MAPS Pneumococcal 24-valent 4406371 (MMRV new strain) Live attenuated vaccine Prevention of pneumonia and invasive pneumococcal disease caused by the Streptococcus pneumoniae 24 serotypes included in the vaccine in adults aged 18 years and older Active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age III III III III III III III II II II II II II II II II II II II II Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies. 278 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition continued Pharmaceuticals and Vaccines product development pipeline continued Compound Mechanism of Action/Vaccine Type Indication Phase MAA NDA/BLA Achieved regulatory review milestones Infectious Diseases continued 3993129 (CMV) 4382276† (mRNA Seasonal Flu) 4396687† (mRNA COVID-19) 3943104† (Therapeutic HSV) 4077164† (iNTS (Typhimurium + Enteritidis)) 4077164† (iNTS (S. typhimurium + S. enteritidis + S. Typhi)) Recombinant subunit – adjuvanted vaccine Cytomegalovirus (CMV) infection prophylaxis in females 16-49 years of age mRNA vaccine mRNA vaccine Recombinant protein-adjuvanted Active immunization for the prevention of influenza disease in adults 18 years and older Active immunization to prevent COVID-19 disease caused by SARS-CoV-2 in individuals 12 years and older Treatment for the suppression of recurrent genital herpes in adults aged 18 years and older Bivalent Generalized Modules for Membrane Antigens (GMMA) vaccine Invasive non-typhoidal salmonella Bivalent Generalized Modules for Membrane Antigens (GMMA) vaccine and typhoid conjugate vaccine (TCV) Invasive non-typhoidal salmonella and typhoid fever 4348413 (Gonorrhoea) Generalized Modules for Membrane Antigens (GMMA) vaccine Hepatitis B virus-targeted siRNA sequential combination FimH antagonist CRK-12 inhibitor Proteasome inhibitor Active immunization for the prevention of gonorrhea infection in individuals aged 16 to 50 years Chronic hepatitis B virus infection Uncomplicated urinary tract infection (uUTI) Visceral leishmaniasis Visceral leishmaniasis Mtb cholesterol dependent inhibitor Tuberculosis PI4K beta inhibitor Viral COPD exacerbations Bivalent Typhoid and Paratyphoid A conjugate Salmonella typhoid and paratyphoid (A) enteric fever PAPD5/PAPD7 inhibitor Chronic hepatitis B virus infection TLR8 agonist Chronic hepatitis B virus infection P falciparum whole cell inhibitor P falciparum whole cell inhibitor Malaria Malaria daplusiran + tomligisiran 3882347† 3186899†3 3494245† 2556286† 3923868 3536867† (Salmonella (typhoid + paratyphoid A)) 3965193 5251738† 3772701† 4024484† II II II II II II II II I I I I I I I I I I Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies. Footnote (3) Transition activities underway to enable further progression by partner. 279 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition continued Pharmaceuticals and Vaccines product development pipeline continued Compound Mechanism of Action/Vaccine Type Indication Phase MAA NDA/BLA Achieved regulatory review milestones Immunology and Respiratory Nucala (mepolizumab) Anti-IL5 depemokimab† Anti-IL5 (long-acting) latozinemab† Anti-sortilin monoclonal antibody COPD Asthma Chronic rhinosinusitis with nasal polyps (CRSwNP) Eosinophilic granulomatosis with polyangiitis (EGPA) Hypereosinophilic syndrome (HES) Frontotemporal Dementia (FTD) due to Heterozygous Mutations in the Progranulin Gene Amyotrophic Lateral Sclerosis (ALS) Frontotemporal Dementia (FTD) due to Mutations in the C9orf72 Gene camlipixant P2X3 receptor antagonist Refractory chronic cough Ventolin, low carbon version of metered dose inhaler Beta 2 adrenergic receptor agonist Asthma4 Benlysta (belimumab) Anti-B lymphocyte stimulator monoclonal antibody Systemic sclerosis associated interstitial lung disease 3858279† Anti-CCL17 Osteoarthritis pain Diabetic peripheral neuropathic pain Anti-sortilin monoclonal antibody Alzheimer's disease Anti-IL18 Anti-IL7 Atopic dermatitis Autoimmune disease Transglutaminase 2 (TG2) inhibitor Pulmonary fibrosis RNA-editing oligonucleotide Alpha-1 antitrypsin deficiency Anti-IL33 COPD Interferon pathway modulator Systemic lupus erythematosus III III III III III III II II III III II II II II II I I I I I 4527226 (AL101)† 1070806 3888130† 3915393† 5462688† 3862995 4347859 Opportunity Driven Jesduvroq (daprodustat) linerixibat 4532990† 4172239† Prolyl hydroxylase inhibitor Anaemia of chronic kidney disease Approved A:Feb23 Ileal bile acid transporter (IBAT) inhibitor Cholestatic pruritus in PBC (primary biliary cholangitis) HSD17B13 silencer DNMT1 inhibitor Non-alcoholic steatohepatitis (NASH) Sickle cell disease III II I Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies. Footnote (4) Phase III start expected in 2024. 280 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition continued Pharmaceutical products, competition and intellectual property Products Compounds Indication(s) competitor brands US EU Major Patent expiry dates1 Respiratory Anoro Ellipta umeclidinium bromide/ vilanterol trifenatate COPD Avamys/Veramyst fluticasone furoate Allergic rhinitis Spiolto/Stiolto Respimat, Utibron/Ultibro Breezhaler, Duaklir Genuair Bevespi Aerosphere, Brimica Genuair Dymista, Xhance, Nasonex, Fluticasone Gx Nucala mepolizumab Asthma, CRSwNP, EGPA, HES Fasenra Relvar/Breo Ellipta fluticasone furoate/ vilanterol trifenatate Asthma, COPD Seretide/Advair salmeterol xinafoate/ fluticasone propionate Asthma, COPD Symbicort, Foster, Budesonide/Formoterol generics, Fluticasone Propionate/Salmeterol generics, Beclomethasone/ Formoterol generics, Atectura Symbicort, Foster, Budesonide/Formoterol generics, Fluticasone Propionate/Salmeterol generics, Beclomethasone/ Formoterol generics, Atectura 2027 (NCE) 2027-2031 (device) 2029 (NCE) 2024-2026 (device) expired expired expired2 expired2 2025 (NCE) 2027-2031 (device) 2027 (NCE) 2024-2026 (device) expired (Diskus device) 2023-2026 (HFA-device) expired (Diskus device) expired (HFA-device) Trelegy Ellipta fluticasone furoate/ vilanterol trifenatate umeclidinium bromide COPD, asthma Breztri Aerosphere, Trimbow 2027 (NCE) 2027-2031 (device) 2029 (NCE) 2024-2026 (device) Ventolin Salbutamol sulphate Asthma, COPD Salbutamol/SABA generics, Symbicort as reliever (PRN & MARTI)3, Airsupra (US only) 2023-2026 (HFA-device) expired (HFA-device) Xevudy sotrovimab Early treatment of COVID-19 REGEN-COV, bamlanivimab/ 2041 2041 Central nervous system Lamictal lamotrigine Epilepsy, bipolar disorder Keppra levetiracetam Epilepsy etesevimab, Evusheld Vimpat, Trokendi XR, Inovelon, Keppra, generics Briviact, Vimpat, Lamictal, Depakene, Depacon, generics expired expired NA NA Cardiovascular and urogenital Avodart & Duodart dutasteride dutasteride + tamsulosin Anti-bacterials Augmentin Amoxicillin trihydrate/ potassium clavulanate Benign prostatic hyperplasia (BPH) Generics, Finasteride, Alpha Blockers expired expired Common bacterial infections Generics, Oral NA expired Cephalosporins – Cefuroxime axetil, Cefixime, Cefpodoxime, Cefdinir, Cephalexin Oral Macrolides – Azithromycin, Clarithromycin (1) Unless otherwise stated, patent expiry dates relate to the latest expiring new molecular entity patents in the relevant territory. Where appropriate, these patent expiry dates include granted Patent Term Extensions in the US, granted Supplementary Protection Certificates in multiple countries of the EU and in the UK, and Paediatric Exclusivity periods. Additional exclusivities (for example regulatory data protection or other types of patents) may exist but are not listed in the table. (2) Regulatory data protection expires 2027 (US) and 2026 (EU). (3) PRN = use as required *MART = maintenance and reliever therapy. 281 Dermatology Dermovate, Betnovate, Cutivate, Eumovate Oncology Zejula Jemperli dostarlimab Ojjaara/Omjjara momelotinib Immuno-inflammation Benlysta, Benlysta (SC and IV) belimumab Renal Jesduvroq, Duvroq Daprodustat HIV Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition continued Pharmaceutical products, competition and intellectual property continued Products Compounds Indication(s) competitor brands US EU Major Patent expiry dates1 Clobetasol propionate, Betamethasone valerate, Fluticasone propionate, Clobetasone butyrate Inflammatory skin conditions Generics, Other topical corticosteroids like Mometasone furoate, Methylprednisolone aceponate and Hydrocortisone Not marketed in US expired niraparib ovarian cancer Lynparza, Rubraca Blenrep belantamab mafodotin relapsed/refractory multiple myeloma Abecma, Carvykti, Tecvayli, Talvey, Elrexfio dMMR/MSI-H recurrent/ advanced endometrial cancer, dMMR solid tumours myelofibrosis in patients with anemia systemic lupus erythematosus, lupus nephritis Keytruda, Imfinzi+Lynparza 2034 Jakafi, Inrebic, Vonjo 2030 2028 Lupkynis, Saphnelo 2025 2026 anaemia of chronic kidney disease Evrenzo (roxadustat), vadadustat 2031 2032 2027 2026 2026 2029 2028 2032 2032 2034 Not approved in EU 2031 2031 2025 2029 2029 2029 2029 Apretude Cabotegravir HIV prevention Descovy, Truvada Cabenuva/Vocabria + Rekambys Cabotegravir, rilpivirine HIV/AIDS Descovy, Genvoya, Odefsey, Biktarvy Rukobia Dovato Fostemsavir HIV/AIDS Trogarzo, Sunlenca Dolutegravir, lamivudine HIV/AIDS Descovy, Genvoya, Odefsey, Biktarvy Juluca Dolutegravir, rilpivirine HIV/AIDS Triumeq Dolutegravir, lamivudine and abacavir HIV/AIDS Tivicay Dolutegravir HIV/AIDS Descovy, Genvoya, Odefsey, Biktarvy 2028 Descovy, Genvoya, Odefsey, Biktarvy 2028 Isentress, Prezista Symtuza, Reyataz, Biktarvy 2028 (1) Unless otherwise stated, patent expiry dates relate to the latest expiring new molecular entity patents in the relevant territory. Where appropriate, these patent expiry dates include granted Patent Term Extensions in the US, granted Supplementary Protection Certificates in multiple countries of the EU and in the UK, and Paediatric Exclusivity periods. Additional exclusivities (for example regulatory data protection or other types of patents) may exist but are not listed in the table. 282 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Pipelines, products and competition continued Vaccine products, competition and intellectual property Major Patent expiry dates1 Compounds Indication(s) competitor brands Respiratory syncytial virus vaccine Respiratory syncytial virus vaccination Abrysvo meningococcal group-B vaccine Meningitis group B prophylaxis Trumenba diphtheria, tetanus, acellular pertussis diphtheria, tetanus, acellular Pertussis booster vaccination Adacel diphtheria, tetanus, pertussis, polio, hepatitis B, Haemophilus influenzae type B (EU) Prophylaxis against diphtheria, tetanus, pertussis, polio, hepatitis B, Haemophilus influenzae type B (EU) Pentacel, Pediacel, Pentaxim, Pentavac, Hexaxim, Hexyon Vaxelis US 2030 2027 EU 2032 2028 expired expired expired expired human papilloma virus type 16 and 18 Gardasil (Silgard) Not marketed in US expired HPV 16 & 18 virus like particles (VLPs), AS04 adjuvant (MPL + aluminium hydroxide) split inactivated influenza antigens (2 virus subtypes A and 2 subtype B) seasonal influenza prophylaxis split inactivated influenza antigens (2 virus subtypes A and 2 subtype B) seasonal influenza prophylaxis Intenza, Flumist QIV, Vaxigrip QIV, Fluzone QIV, Fluzone High Dose Vaxigrip, Mutagrip, Fluzone, Influvac, Aggripal, Fluad, Intenza, Flumist expired expired expired expired Products Arexvy Bexsero Boostrix Infanrix Hexa/ Pediarix Cervarix Fluarix Tetra FluLaval Menveo meningococcal group A, C, W-135 and Y conjugate vaccine Meningitis group A, C, W-135 and Y prophylaxis Nimenrix, MenQuadfi 2025 2025 Priorix, Priorix Tetraa, Varilrix live attenuated MMR, Varicella and MMRV vaccines measles, mumps, rubella and chickenpox prophylaxis MMR II (M-M-RVaxPro) Proquad, Varivax expired expired Rotarix Synflorix Shingrix Human rotavirus RIX4414 strain conjugated pneumococcal polysaccharide Rotavirus prophylaxis Rotateq expired expired Prophylaxis against invasive disease, pneumonia, acute otitis media Prevenar (Prevnar) Note marketed in US 2026 zoster vaccine recombinant, adjuvanted herpes zoster (shingles) Zostavax 2029 2031 (1) Unless otherwise stated, patent expiry dates relate to the latest expiring new molecular entity patents in the relevant territory. Where appropriate, these patent expiry dates include granted Patent Term Extensions in the US, granted Supplementary Protection Certificates in multiple countries of the EU and in the UK, and Paediatric Exclusivity periods. Additional exclusivities (for example regulatory data protection or other types of patents) may exist but are not listed in the table. 283 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties We outline below the principal risks and uncertainties relevant to GSK’s business, financial condition and operations that may affect our performance and ability to achieve our objectives. These are the risks that we believe could cause our actual results to differ materially from expected and historical results. Operating in the biopharmaceutical sector carries various inherent risks and uncertainties that may affect our business. We must comply with a broad range of laws and regulations which apply to the research and development, manufacturing, testing, approval, distribution, sales, and marketing of pharmaceutical and vaccine products. These affect the cost of product development, the time required to reach the market and the likelihood of doing so successfully on an uninterrupted basis. As rules and regulations change, government interpretation and policy evolves, and our business activities develop, the nature of a particular risk may also alter. Changes to regulatory regimes may be substantial. Any alteration in, and failure to comply with, applicable laws and regulations could materially and adversely affect our financial results. Similarly, our global business exposes us to litigation and government investigations, including product liability litigation, patent and antitrust litigation and sales and marketing litigation. Litigation and government investigations, and the related provisions we may make for unfavourable outcomes and increases in related costs, such as insurance premiums, could also materially and adversely affect our financial results. More detail on the status and various uncertainties in our significant unresolved disputes and potential litigation is set out in Note 47 ‘Legal proceedings’on page 239. More details regarding our risk management framework and how we identify our principal risks can be found on pages 57 to 61 and incorporated in this section. Other risks related to Environmental, Social, and Governance (ESG) which are not at the level of principal risks, including environmental sustainability and climate change, are managed through our six focus areas, and as described in our ESG Performance Report. Additional information on climate-related risk management is in our climate-related financial disclosure on pages 62 to 70. UK regulations require a description of principal risks and uncertainties and an explanation of how these are being managed or mitigated. Below is a description of each of our principal risks, together with a summary of their impact and how we manage each risk across our businesses. They are not listed in order of significance and are consistent with the principal risks detailed on pages 59 to 61. Patient safety Risk definition The risk that GSK, including our third parties, fails to appropriately collect, assess, follow up, or report human safety information, including adverse events, from all potential sources or that GSK potentially fails to appropriately act on any relevant findings that may affect the benefit-risk profile of a medicine or vaccine in a timely manner. Risk impact GSK will not tolerate an unfavourable benefit-to-risk profile for patients who use our products. As the most important consequence of ineffective pharmacovigilance is the potential for harm to patients, we maintain robust processes for managing human safety information, conducting timely safety signal detection, and ensuring appropriate measures are in place to manage risks to patients. GSK also intends to fully comply with pharmacovigilance and other relevant regulations worldwide. Non-compliance could result in inspection findings, regulatory scrutiny, civil or criminal sanctions and either temporary or permanent loss of product marketing authorisation. We regularly review and respond to all patient safety risks to limit the potential for reputational damage, loss of trust by patients and healthcare providers, product-related litigation, and loss of shareholder confidence. Context We are accountable for safeguarding patients and clinical trial participants who receive our medicines and vaccines, whether in development or marketed, from harm. While an unforeseen event that unfavorably shifts the benefit/risk profile is not a probable occurrence, such an event cannot be fully discounted; we mitigate this risk through robust safety evaluation and product risk management activities. Our Chief Medical Officer is the single point of accountability for benefit/risk decision-making. Cross-functional Safety Review Teams continually assess new safety and efficacy information for every GSK product throughout its life cycle. Our Global Safety Board, under the leadership of our Chief Medical Officer and Head of Global Safety, reviews product safety at established milestones and in every situation where there might be a potential impact on a benefit/risk profile. We must operate in a complex and restrictive pharmacovigilance regulatory environment, sometimes complicated by variable requirements between regulatory agencies. Such regulatory complexity is further illustrated by instances of regulatory agencies taking decisions on the safety of medicines and vaccines based on externally available data that may not be accessible to the marketing authorisation holder. This trend could inhibit our ability to make timely decisions and take appropriate action in relation to the safety of our products, or to confirm or refute conclusions asserted by external parties. This has the potential to extend beyond regulatory agencies to next-generation digital health data held by technology companies or other data custodians, and inaccessible by our industry and/or regulatory agencies. 284 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Patient safety continued There are many sources of information that might trigger an increase in reporting related to products and/or adverse events (such as media coverage, social media, government health authorities, etc.). Ineffective management of patient safety risks could not only result in reputational damage, loss of trust by patients and healthcare providers, and decline in shareholder confidence, but could also increase the volume of product- related litigation, including class-action lawsuits, which is regularly faced by GSK and our industry in general. Mitigating actions Our Chief Medical Officer is accountable for the Patient Safety enterprise risk and human safety matters, in collaboration with the Head of Global Safety. A cross-enterprise safety governance board oversees implementation of our control framework, including risk management. Our Global Safety Board ensures that we address human safety proactively throughout a product’s lifecycle. Our global policy on management of human safety information requires that all employees immediately report issues relating to the safety of our products. Our third party risk management framework supports us in identifying and training any third parties who may encounter human safety information. Product quality In 2023, we took additional steps to strengthen how we safeguard patients and enhance the execution of our pharmacovigilance operational activities. We have added risk management and benefit/risk expertise to our Global Safety organisation that will enhance our ability to define the risk management strategy for an evolving portfolio for which more complex risk minimisation measures may be required, to be followed in 2024 with a new system that will better enable us to track the implementation and effectiveness of our risk management plans. We have transitioned to a simplified, more efficient approach for collecting, following up, and reporting human safety information including adverse events from all potential sources. We are continuing to build capability across all GSK staff who hold accountability for our Pharmacovigilance Quality Management System and are in the process of embedding a simplified process for managing pharmacovigilance agreements and safety clauses between GSK and third parties, including our strategic partners. Risk definition The risk that GSK or our third parties potentially fail to ensure appropriate controls and governance of quality for development and commercial products are in place; compliance with industry practices and regulations in manufacturing and distribution activities; and terms of GSK product licenses and supporting regulatory activities are met. Mitigating actions We align an extensive global network of quality and compliance professionals from site-level to senior management within each business unit to provide oversight and assist with the delivery of quality performance and operational compliance. We deliver this management oversight through a hierarchy of quality councils and a Global Head of Quality. Risk impact A failure to ensure product quality could have far-reaching implications for patient safety, cause product launch delays, drug shortages or product recalls, and have regulatory, legal, and financial consequences. These could materially and adversely affect GSK’s reputation and financial results. Context The external environment for product quality remains challenging. An increase in supplier mergers in our supply network can create challenge in influencing their quality standards. The rapid advancement and use of digital technologies such as artificial intelligence and machine learning (AI/ML) within an evolving regulatory framework introduces both opportunity for modernisation and potential to impact product quality if not adequately controlled. There will be a need to adopt and adapt to new, updated guidance on this as it emerges. The threat of cyber-attacks and data breaches across the industry could risk the integrity of product quality data and its audit trail. Additionally, a gradual divergence in regulatory expectations during inspections, particularly from some health authorities, presents a challenge to our sites as they prepare for inspections. Retaining expertise in biopharma and the deep capability to support digital progression has the potential to be a challenge in a highly competitive environment. We are expanding our Quality Management System, Good Manufacturing Practice Audit and Quality assurance oversight programme across R&D to ensure that we mitigate potential product quality risk across the end-to-end process. We have implemented a risk-based approach to assessing and managing third party suppliers that provide materials used in our finished products including monitoring third party labs and how they are independently checking goods. We expect contract manufacturers that make our products to comply with GSK standards and regularly conduct audits to provide us with assurance. We use key risk indicators to support risk management activities and provide leadership teams and quality councils with an integrated assessment of product quality performance. Throughout 2023, we continued to actively manage the deployment of plans to align with the New Annex 1 guidance for the manufacture of sterile medicinal products in the context of global equipment and component supply chain constraints effecting the industry. We are increasingly applying advanced digital technologies and insights to drive scientific excellence to enhance and modernise the development, manufacture and testing of our products and to protect our data. We are actively contributing to industry advocacy and to influence thinking on the regulatory frameworks for these advancing technologies to support patient safety benefit and access. 285 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Product quality continued We are collaboratively working with other pharma companies and industry trade associations to respond to questions from the EMA and completing the safety evaluation of the use of Titanium Dioxide in medicines, as well as identifying potential substitutes. We are working with industry to monitor emerging risk factors and regulatory intelligence and guidance on Nitrosamines. We continue to adapt our procedures to the evolving expectations on this topic and work on our mitigation plans alongside regular engagement with regulators, at all times ensuring our inspection readiness for all the markets we serve. Financial controls and reporting Risk definition The risk that GSK fails to comply with current tax laws; fails to report accurate financial information in compliance with accounting standards and applicable legislation; or incurs significant losses due to treasury activities. Risk impact Non-compliance with existing or new financial or new ESG reporting and disclosure requirements, or changes to the recognition of income and expenses, could expose GSK to litigation and regulatory action and could materially and adversely affect our financial results. Failure to comply with changes in the substance or application of the laws governing transfer pricing, dividends, tax credits and intellectual property could also materially and adversely affect our financial results. Failure to comply with applicable laws and regulations could result in GSK being investigated by relevant government agencies and authorities and/or in legal proceedings against us. Government investigations and litigation, can be unpredictable and regardless of their outcome, may be costly, require significant management attention, and damage our reputation. Inconsistent application of treasury policies, transactional or settlement errors, or counterparty defaults could lead to significant losses. Context We are required by the laws of various jurisdictions to publicly disclose our financial results and any events that could materially affect the Group’s financial results. Regulators routinely review the financial statements of listed companies for compliance with new, revised, or existing accounting and regulatory requirements. We believe that we comply with the appropriate regulatory requirements concerning our financial statements and the disclosure of material information, including any transactions relating to business restructuring such as acquisitions and divestitures. However, should we be subject to an investigation into potential non-compliance with accounting and disclosure requirements, this could lead to restatements of previously reported results and significant penalties. Our Treasury group deals daily in high value transactions, mostly foreign exchange, and cash management transactions. These transactions involve market volatility and counterparty risk. The Group’s effective tax rate reflects the locations of our activities and the value they generate, which determine the jurisdictions in which profits arise and the applicable tax rates. These may be higher or lower than the UK statutory rate and may reflect regimes that encourage innovation and investment in R&D by providing tax incentives which, if changed, could affect GSK’s tax rate. In addition, the worldwide nature of our operations means that our cross-border supply routes, necessary to ensure supplies of medicines and vaccines, can result in conflicting claims from tax authorities as to the profits to be taxed in individual countries. This can lead to double taxation, with profits taxed in more than one country. The complexity of tax regulations also means that we may occasionally disagree with tax authorities on the technical interpretation of a particular area of tax law. The tax charge included in our financial statements is our best estimate of tax liability pending any audits by tax authorities. We expect there to be a continued focus on tax reform, driven by initiatives by the OECD and the EC to address the tax challenges arising from digitalisation of the economy. Together with domestic initiatives around the world, these may result in significant changes to established tax principles and an increase in tax authority disputes. Regardless of their merit or outcomes, these may be costly, divert management attention and adversely impact our reputation and relationship with key stakeholders. Laws, regulations, orders and other measures restrict dealings with certain countries, governments, government officials, entities, individuals, and the use of financial institutions and movement of funds. Mitigating actions We keep up to date with the latest developments in financial reporting requirements by reviewing updates from regulators, working with our external auditor and legal advisors and performing and responding to emerging risks. Financial results are reviewed and approved by regional management, before being reviewed by GSK’s Group Financial Controller and Chief Financial Officer (CFO). This allows our Financial Controller and CFO to assess the evolution of the business over time, and to evaluate its performance to plan. Significant judgements are reviewed and confirmed by senior management. We integrate technical or organisational transformation, newly acquired activities and external risks into our risk assessments and apply appropriate controls and reviews. We maintain a control environment designed to identify material errors in financial reporting and disclosure. We have a standardised global financial reporting operating model. The design and operating effectiveness of key financial reporting controls are regularly reviewed by management and tested by external third parties. The few locations which are not on the standard model apply a minimum standard set of controls which are reviewed by management and monitored independently. This gives us assurance that controls over key financial reporting and disclosure processes are operating effectively. Our Global Finance Risk Management and Controls (FRMC) group provides extra support during significant transformations, such as system deployment or management/ structural reorganisations. We add operational resources and adapt programme timelines to ensure processes and controls are maintained during significant changes. The Disclosure Committee, reporting to the Board, reviews GSK’s quarterly results and annual report. 286 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Financial controls and reporting continued Throughout the year, in consultation with its legal advisors, the Disclosure Committee also determines whether it is necessary to disclose publicly information about the Group through stock exchange announcements. The Treasury Management Group meets regularly to ensure that liquidity, interest rate, counterparty, foreign currency transaction and foreign currency translation risks are all managed in line with the prudent approach detailed in the risk strategies and policies adopted by our Board. Counterparty exposure is subject to defined limits approved by the Board for both credit rating and individual counterparties. The Middle Office within Treasury monitor the management of counterparty risk in line with agreed policy with oversight from a corporate compliance officer, operating independently of Treasury. Further details on mitigation of Treasury risks can be found on pages 243 to 245. We manage tax risk through robust internal policies, processes, training, and compliance programmes. We maintain open and constructive relationships with tax authorities worldwide. We monitor government debate on tax policy in our key jurisdictions, so that we can understand any potential future changes in tax law and share an informed point of view. Legal matters Risk definition The risk that GSK or our third parties potentially fail to comply with certain legal requirements for the development, supply and commercialisation of our products and operation of business, and specifically in relation to requirements for competition law, anti-bribery and corruption, and sanctions. Any failure to meet compliance and legal standards for these particular areas could lead to increasing scrutiny and enforcement from government agencies. Risk impact Failure to mitigate legal risk could expose GSK and associated persons to governmental investigation, regulatory action, and civil and criminal liability. It may compromise GSK’s ability to supply its products under certain government contracts. In addition, failure to manage legal risk could have substantial implications for GSK’s reputation and the credibility of senior leaders. It might erode investor confidence in our governance, risk management and future performance, and have a consequential negative impact on share performance. It could also lead to the imposition of significant financial penalties and the imposition of additional reporting obligations. Context The overall environment for anti-bribery and corruption, competition law and sanctions and export controls remains challenging. There continues to be a strong enforcement appetite for bribery investigations and prosecutions, with a particular focus on the conduct of multinational companies wherever they operate. The focus on sanctions, export controls and competition law enforcements has increased. From a sanctions perspective, we have seen penalties for violations levied on companies from a number of different industries. Merger control has seen increasing intervention with greater divergence in decisions and policy by enforcement agencies. Financial penalties handed down in these types of case are often very significant. Where relevant, we provide pragmatic and constructive business input to tax policy makers, either directly or through industry trade bodies. This includes advocating reform to support economic growth and job creation, as well as the needs of our patients and other key stakeholders. Our tax affairs are managed on a global basis by a team of tax professionals, led by the Global Head of Tax, who work closely with the business on a day-to-day basis. The Global Tax team is suitably qualified for the roles they perform, and we support their training needs so they can provide up to date technical advice in line with their responsibilities. We submit tax returns according to statutory time limits and engage proactively with tax authorities to ensure our tax affairs are current, entering into continuous audit programmes and advance pricing agreements where appropriate. These arrangements provide long-term certainty for both tax authorities and GSK over the tax treatment of our business, based on full disclosure of all relevant facts. We seek to resolve any differences of interpretation in tax legislation with tax authorities in a cooperative manner. In exceptional cases, we may have to resolve disputes through formal proceedings. Supportive aspects of the external environment include an increase in focus on corporate transparency. Advances in technology and the use of data analytics are also providing better platforms to streamline processes and detect potential issues. Mitigation actions Our Group General Counsel oversees and is accountable for the Legal Matters principal risk. We have enterprise anti-bribery and corruption, competition law and sanctions control frameworks and programmes designed to ensure compliance with applicable laws and regulations, building on our Code, culture and business standards, and monitor and adapt to evolving regulations and our business activities. Our programmes include senior leader commitment, setting the tone at the top. These control frameworks are based on globally recognised and accepted principles and include global policies, written standards and controls to govern business activities that give rise to these risks. We mandate enhanced controls, including due diligence requirements and sanctions screening, for specific high-risk activities such as interactions with government officials, during business development transactions and engagement with third parties. We regularly provide anti-bribery and corruption, competition law and sanctions training to employees, and relevant complementary workers and third parties in accordance with their roles, responsibilities and risks they face. We include aspects of these key risks in our annual mandatory training and reinforce to our workforce clear expectations regarding acceptable behaviours. We leverage data analytics and use information from our monitoring and other assurance activities, key risk indicators, investigations, and Speak Up channels to identify specific areas for intervention, and drive continuous improvements and enhancements to our controls. We investigate allegations of non-compliance and take disciplinary action as required and where permitted locally. 287 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Legal matters continued Dedicated teams are responsible for the implementation and evolution of the risk framework and programmes for anti- bribery and corruption, competition law, and sanctions. Commercial practices Risk definition The risk that GSK or our third parties potentially engage in commercial activities that fail to comply with laws, regulations, industry codes, and internal controls and requirements. Risk impact Failure to engage in activities that are consistent with the letter and spirit of the law, industry regulations, or the Group’s requirements relating to sales and promotion of medicines and vaccines; with appropriate interactions with healthcare professionals (HCPs), organisations and patients; with legitimate and transparent transfers of value; and with pricing and competition (or antitrust) regulations in commercial practices, including trade channel activities and business tendering, could materially and adversely affect our ability to deliver our strategy and long-term priorities. Additionally, it may result in incomplete awareness of the risk/benefit profile of our products and possibly suboptimal treatment of patients and consumers; governmental investigation, regulatory action and legal proceedings brought against the Group by governmental and private plaintiffs which could result in government sanctions, and criminal and/or financial penalties. Any practices that are found to be misaligned with our culture could also result in reputational harm and dilute the trust established with external stakeholders. Context We operate in a highly regulated and extremely competitive biopharma industry, amongst peers who make significant product innovations and technical advances and intensify price competition. Additional external factors include access limitations to our customers, macroeconomic inflationary dynamics, and pricing pressure across markets. To achieve our strategic objectives, we must continue to develop commercially viable new products, sustain reliable supply, and deliver additional uses for existing products that address the needs of patients, consumers, HCPs and payers. We continuously assess, monitor and understand our risk exposure to related risks, including our money laundering risk, and actively consider and implement improvements to the risk framework and programmes based on internal and external learnings, considering the complexity and geographic breadth of the risk. Financially, new products/indications carry with them an uncertainty of future success. Product development is costly, lengthy, and uncertain, and carries the potential for failure at any stage. Even after successful product development, we face challenges in how we launch, and our competitors’ products or pricing strategies could render our assets less competitive. We support product innovation through our continued focus on both in-person and virtual engagement, with a constant focus on our patient. Once we have an approved medicine or vaccine, it is our obligation to provide important information to the healthcare community in various ways, always in a responsible, legal, and ethical manner. Appropriate product promotion ensures HCPs have access to the information they need, that patients and consumers have the facts about the medicines and vaccines they require, and that products are prescribed, recommended, or used in a manner that provides healthcare benefit. We are committed to the ethical and responsible commercialisation of our products in support of our purpose to improve the quality of human life and get ahead of disease together. Mitigating actions We have evolved policies and standards incrementally to ensure that commercial activities that we undertake or are conducted on our behalf are executed within our established governance. We train employees on relevant information with a focus on interactive learning and elements of behavioural science. All our commercial activities worldwide must conform to high ethical, regulatory, and industry standards. Where local standards differ from global ones, we apply those that are most stringent. Where the standards of an acquired company or joint venture partner differ from our global standards, we remediate legacy policies and implement revisions, so they align. Our businesses continue to use our internal control framework to support the assessment and management of risks. 288 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Commercial practices continued Business unit risk management and compliance boards, which manage risks across global and in-country business activities, oversee commercial activities and their monitoring programmes. All promotional materials and activities must be reviewed and approved according to our policies and standards and conducted in accordance with local laws and regulations; these requirements seek to ensure that such materials and activities fairly represent the Group’s products or services. Where necessary, in the event of misconduct, we have disciplined employees, up to and including termination of contract, and, applied/enforced GSK's senior leader recoupment policy. We have continued to evolve our incentive programme for sales representatives to better recognise and reward individual effort. In nearly all markets, the capped variable pay element of representatives’ compensation is evaluated on the basis of individual sales targets. We allow fair-market value payments to be made by GSK to expert practitioners to speak about our innovative medicines and vaccines during a restricted period in a product’s lifecycle, or when new and competitive data is published. To support this, in 2023 we embedded a global end-to-end expert engagement process, rolled out a Healthcare Organisation (HCO) process, created a new standard operating procedure for tenders, updated our External Expert Engagement operating procedure, and further strengthened our interactive digital media channel controls through the identification of all channels, and the contracting of a third party to monitor these channels across GSK, to drive consistent ways of working and efficiencies and strengthen controls through automation and use of data. Where permitted we report payments to individual HCPs as part of our commitment to transparency and responsible disclosure. Scientific and patient engagement Risk definition The risk that GSK or our third parties potentially fail to engage externally to gain insights, educate and communicate on the science of our medicines and associated disease areas, and provide grants and donations in a legitimate and transparent manner compliant with laws, regulations, industry codes and internal controls and requirements. Risk impact Without controls in place, the risk could result in real, perceived, or disguised promotion including off-label and prior authorisation promotion, and real or perceived provision of medical advice. This could lead to reputational damage, competitor complaints, regulatory inspections with subsequent corrective actions, or civil litigation. We must fully and appropriately engage externally to bring patient benefit, and to advance science and innovation, while delivering our strategy. Otherwise, we risk reducing the trust of the public, patients, healthcare professionals, payers, regulators, and governments. Context Scientific and patient engagements are diverse non- promotional activities directed at healthcare professionals, patients, payers, and external stakeholders. Such engagements aim to improve patient care through the exchange or provision of knowledge on the use of our products and related diseases. Scientific and patient engagement with external stakeholder groups is vital to GSK, as a research-based biopharma company that is ambitious for patients and to advance science and medicine. We expect our activities to be scientifically sound and accurate, conducted ethically and transparently, and compliant with applicable codes, laws, and regulations. There are many industry and local codes and laws and other regulations that apply (such as Privacy or Data integrity). That means measured risk-taking, rooted in sound ethical considerations, and principles-based decision-making, training, communication, and monitoring of such activities are key to managing the risk and enabling full and appropriate engagement. Mitigating actions Our Chief Medical Officer (CMO) oversees all non-promotional scientific and patient engagement (SPE) as enterprise risk owner. The GSK Code of Practice is the key internal policy for non-promotional engagement activities. These activities include scientific interactions, support for medical education, advice seeking, gathering insights on unmet needs of patients, scientific communication of our research, and disease awareness, healthcare support services and patient support programs. Process simplification continued into 2023. Global process owners accountable for the end-to-end process have been assigned for the simplified processes: Seeking Advice, Content Approval, Medical Information and Medical Education. This accountability includes the comprehensive oversight of the process, the creation of an appropriate internal control framework and continuous evaluation of process for improvement where necessary. All SPE materials and activities must be reviewed and approved according to our policies and standards. Additional controls for the review of SPE content have been implemented to continue to ensure content is non-promotional, accurate, fair, objective and balanced and will not be perceived as promotion. We have further modernised our digital approach to HCPs, embedded our framework for interactions with patients and patient organisations, and developed our policy for healthcare support services and patient support programmes and applied our internal principles to these activities. An internal framework for Software as Medical Device was established including an Expert Panel that provides business owners with multi- disciplinary advice. The cross-business unit SPE risk council oversees SPE activities and reviews monitoring and audit data, while the SPE network reviews the maturity of the internal control framework of the SPE processes. We continuously improve our internal controls, systems and networks to identify emerging risks early and to support staff to conduct activities in compliance with GSK’s culture and policies and local laws and regulations while building effective risk management and management monitoring systems. . 289 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Data ethics and privacy Risk definition The risk that GSK or our third parties potentially fail to ethically collect; use; re-use through artificial intelligence, data analytics or automation; secure; share and destroy personal information in accordance with laws, regulations, and internal controls and requirements. Risk impact Non-compliance with data privacy laws globally could lead to harm to individuals and GSK. It could also damage trust between GSK and individuals, communities, business partners and government authorities. Many countries have increased the enforcement powers of their data protection authorities by allowing them to impose significant fines, restrict cross-border data flows, or temporarily ban data processing. Many new national laws also enable individuals to bring collective legal actions against companies such as GSK for failing to follow data privacy laws. Context Data protection and privacy legislation is diverse, with limited global harmonisation or simplification, making it challenging for multinationals to standardise their approach to compliance. Governments are enforcing compliance with data protection and privacy laws more rigorously. The approach and focus of data protection and privacy regulators also differs between regions and countries, which creates further challenges for global organisations seeking to implement a single harmonised global privacy programme. Increases in the volume of data processed and advances in technology have resulted in a greater focus on data governance and the ethical use of personal information, over and above compliance with data privacy laws. Companies seeking to foster innovation in artificial intelligence and other new technologies are faced with evolving decisions from global policymakers on how best to promote trust in these systems and avoid unintended outcomes or harmful impacts. Additionally, there are a number of emerging laws concerning the localisation of data, restrictions on international transfers and data security, which are changing existing frameworks that GSK has previously relied upon. This increasing trend for data sovereignty affects our ability to drive medical innovation and to effectively operate internationally. Global regulators (such as the EU, UK, US and China) are also in the process of introducing legislation around the use of artificial intelligence and machine learning (AI/ML). There continues to be considerable uncertainty around the final version of these proposed laws. Mitigating actions Our General Counsel is GSK’s Enterprise Risk Owner (ERO), and chairs our Digital and Privacy Governance Board, which oversees GSK’s overall data ethics and privacy operating model. Each GSK business area has appointed a risk owner accountable for overseeing its privacy risks, supported by privacy leaders within their business. In countries where local data privacy laws require the appointment of a Data Protection Officer (DPO), GSK has made such appointments, including an EU DPO. As a result of GSK’s focus on technology, data-driven science, use of AI/ML and our evolving global data strategy, the ERO has appointed a Head of Digital, Privacy and Cybersecurity (Head of DPC), who has day-to-day accountability for designing and implementing the control framework. The Head of DPC leads a global, cross-functional core team of digital- and privacy-qualified attorneys and compliance professionals, supported by a network of privacy leaders within business units/functions, privacy contacts locally, and the wider Legal & Compliance team. GSK has a global data ethics and privacy framework based on the EU General Data Protection Regulation, which is deployed in every market based on factors including the robustness of local privacy legislation, established data protection authorities, and GSK’s footprint. Beyond those countries, we have deployed a proportionate control framework to set up minimum privacy standards irrespective of any applicable legislation. Our core team is responsible for: – operating and improving the centralised global data ethics and privacy control framework – continuously assessing and providing relevant and proportionate controls and aid to non-deployed markets – monitoring new, or changing, laws and adapting the privacy framework accordingly – deploying a comprehensive training programme to drive greater awareness and accountability for managing personal information across the entire organisation – legal and regulatory expertise in emerging technologies, including artificial intelligence and machine learning We ensure key GSK privacy network roles have sufficient training and experience to carry out their roles effectively. We continuously improve our processes, such as issue identification, reporting and handling, through monitoring. Our core team works with the business to ensure we build in privacy controls into all existing and new business initiatives, as well as ensuring we meet our accountability obligations in accordance with global data protection and privacy laws. 290 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Research practices Risk definition The risk that GSK or our third parties potentially fail to adequately conduct ethical and credible pre-clinical and clinical research, collaborate in research activities compliant with laws, regulations, and internal controls and requirements. Risk impact The potential impacts of the risk include harm to human subjects, reputational damage, failure to obtain the necessary regulatory approvals for our products, governmental investigation, legal proceedings brought against GSK by governmental and private plaintiffs (product liability suits and claims for damages), loss of revenue due to inadequate patent protection or inability to supply our products, and regulatory action such as fines, penalties, or loss of product authorisation. Poor data integrity and governance could compromise GSK’s R&D efforts and negatively impact our reputation. Any of these could materially and adversely affect our financial results and damage the trust of patients and customers. Context Research involving animals can raise ethical concerns. In many cases, however, research involving animals is the only way to investigate the effects of a potential new medicine in a living body other than in humans. Animal research provides critical information about the causes and mechanisms of diseases and therefore remains a vital part of our research. We continually seek ways in which we can minimise our use of animals in research, development, and testing, while complying with regulatory requirements and reducing the impact on the animals used. Human subject research is critical to assessing and demonstrating the safety and efficacy of our investigational products or further evaluating our products once they have been approved. This research includes clinical trials in healthy volunteers and patients and adheres to regulations and high ethical, medical, and scientific standards. We disclose the results of this research externally regardless of whether they reflect positively or negatively on our products, so that the scientific community can learn from the outcomes of our research. We also work with human biological samples which are fundamental to the discovery, development, and safety monitoring of our products. We are committed to managing human biological samples in accordance with relevant laws, regulations, and ethical principles, and in a manner that respects the interests of sample donors. Data is pivotal to our R&D strategy, and we are maximising the use of data to serve patients. Governing our data in accordance with relevant laws, regulations, contractual obligations, expectations, and our culture across data ethics, privacy, information and cyber security, and data integrity is essential. We use a wide variety of biological materials in the discovery, research, and development of our assets. We are committed to ensuring research is compliant with terms and conditions of licenses, agreements or authorisations under which we acquire, use, or transfer biological materials and technologies. Through the Convention on Biological Diversity (CBD) and the Nagoya Protocol, the international community has established a global framework regulating access to, and use of, genetic resources of non-human origin in research and development. We support the equitable access and fairness principles of access and benefit sharing (ABS) outlined in the CBD and the Nagoya Protocol. We also recognise the importance of appropriate, effective, and proportionate implementation measures at national and regional levels. Mitigating actions The Research Practices risk is overseen by an enterprise framework that seeks to strengthen governance across R&D. Under the leadership of the Research Practices Enterprise Risk Owner, management of the risk takes a pragmatic approach to information sharing, streamlining risk identification and escalation while ensuring ownership of risk mitigation stays with the business. We have an established Office of Animal Welfare, Ethics and Strategy and Risk (OAWESR), led by our Chief Veterinary Officer, which oversees and ensures the humane and responsible care and use of animals, the conduct of ethical reviews and independent scientific reviews of animal studies, and advocates for the application of non-animal alternatives. The OAWESR provides a framework of animal welfare governance; defines and provides oversight for animal care and use programmes; promotes the replacement, refinement, and reduction of animal use in research; conducts quality assessments and manages a programme of due diligence of external animal research. Ensuring we implement and maintain proper data governance controls remains an important priority, especially as our scientific strategy is evolving to take advantage of the breadth of our data (for example: genomics and artificial intelligence and machine learning (AI/ML)). We focus on building data integrity, privacy and usage controls into our internal control framework. Quality assurance teams conduct audits to provide independent business monitoring of our internal controls. Our R&D organisation maintains and controls pre-publication procedures to guard against public disclosure before patent applications are filed. In addition, because a lack of data integrity in preparing patent application data and information can lead to a loss of patent protection, legal experts collaborate with R&D to support the review process for new patent applications. Our R&D organisation also collaborates with legal experts throughout the development of our assets to take account of any relevant third-party patent rights. 291 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Environment, health, and safety (EHS) Risk definition The risk that GSK or our third parties potentially fail to ensure appropriate controls and governance of the organisation's assets, facilities, infrastructure, and business activities, including execution of hazardous activities, handling of hazardous materials, or release of substances harmful to the environment that disrupts supply or harms employees, third parties or the environment. Risk impact Failure to manage EHS risks could lead to significant harm to people, the environment and the communities in which we operate, fines, inability to meet stakeholder expectations and regulatory requirements, litigation or regulatory action, and damage to the company’s reputation, which could materially and adversely affect our financial results. Context GSK is subject to the health, safety and environmental laws of various jurisdictions. These laws impose duties to protect people, the environment and the communities in which we operate. Mitigating actions The GSK Leadership Team is responsible for EHS governance and risk oversight. They ensure there is an effective control framework ‘in-place’ and ‘in-use’ to manage the EHS risks, impacts, and legal compliance issues in each of our businesses. This includes assigning responsibility to senior managers for providing and maintaining our controls and for ensuring that tiered monitoring and governance processes are in place within their business units. Information and cyber security Risk definition The risk that GSK or our third parties potentially fail to ensure appropriate controls and governance to identify, protect, detect, respond, and recover from cyber incidents through unauthorised access, disclosure, theft, unavailability or corruption of GSK's information, key systems, or technology infrastructure in accordance with applicable laws, regulations, industry standards, internal controls and requirements. Risk impact Failure to adequately protect our information and systems against cyber security threats may cause harm to patients, workforce and customers, disruption to our business and/or loss of commercial or strategic advantage, regulatory sanction, or damage to our reputation. Function leaders ensure that the EHS control framework is implemented effectively in their respective business area, that it is compliant with applicable laws and regulations, and that it is adequately resourced, maintained, communicated, and monitored. Every employee and qualified contractor acting on behalf of GSK is personally responsible for ensuring that they follow all applicable local standard operating procedures. Our risk-based, proactive approach is articulated in our global EHS policy and detailed in our global EHS standards, against which we audit all our operations to ensure compliance. We ensure hazards are appropriately controlled through the design of facilities, equipment and systems. These rigorous procedures, when applied correctly, put effective barriers in place to protect employees’ health and safety. We have refreshed and rebranded the 12 Life Saving Rules across GSK, with global initiatives to embed the rules in daily operations. Our Safety Leadership Experience training continues across GSK, using incident knowledge to enhance learnings and build a strong, collaborative safety culture. Our Contractor Safety assessment is being deployed with the support of an external expert review of current GSK contractor management. We are improving driver safety through safer cars and enhanced training. Context The external environment continues to be extremely challenging, making it hard to keep pace with increasingly sophisticated cyber security threats. Factors include increased geopolitical conflict and digital nationalism, rising frequency and severity of data breaches and the growing capability and sophistication of cyber threat actors with additional tools like generative AI to propagate their attacks. GSK’s business relies on operating a highly connected information network of internal and external systems which hold confidential research and development, manufacturing, commercial, workforce and financial data. This means that our systems and information have been and will continue to be targeted by cyber security threat actors. Acceleration in the use of digital, data and analytics, AI/ML and cloud computing capabilities to drive GSK’s pipeline, performance and productivity requires us to continuously adapt and strengthen our controls and defensive capabilities. 292 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Information and cyber security continued GSK also relies on third-party contractors, partners and suppliers who face similar cyber security threats, which emphasises our focus on third party risk management. Additionally, hybrid working environments create a larger and more complex attack surface for cyber security threat actors to exploit. With employees accessing company resources from various locations and devices, new threats and vulnerabilities could arise. Mitigating actions How we manage cyber security risk We use our corporate enterprise risk management and internal control framework to manage and oversee our Information and Cyber Security principal risk, and we follow our corporate governance hierarchy for risk reporting and escalation. Our Chief Information Security Officer (CISO) heads our Cyber Security Office and is responsible for identifying and putting in place controls and measures to help GSK mitigate and manage cyber security risks. This includes actively monitoring and initiating remediation or other actions to respond to cyber security intelligence and threats. It also includes ongoing investment in people, process and technology to improve our ability to prevent, detect, respond to and recover from any cyber security incidents. We monitor this risk using key risk indicators which include tolerance thresholds reported monthly to the business and quarterly through the governance channels. We also have a third-party security risk management programme to assess cyber security risk when selecting and on- boarding third parties like external partners and suppliers. We use widely accepted standards and frameworks to benchmark our internal environment and controls and help define our security objectives and desired security outcomes. While our standards and frameworks can evolve in response to our dynamic threat environment, we also rely on external frameworks including: – the National Institute of Standards and Technology (NIST) Cyber Security Framework for measuring the overall cyber readiness and maturity – the International Organisation for Standardisations (ISO) 27001/27002 for general information technology controls – Sarbanes-Oxley (SOX) for assessment of internal controls We also draw on third-party consultants' expertise in processes for assessing, identifying and managing cyber security risks. This year, our cyber security maturity programme, designed to reduce the risk of our data being compromised, has improved our security posture and our ability to detect, protect against, respond to and recover from malicious cyber activity. We also created an AI Governance Council, which includes the CISO, to assess and manage information security risks around adopting and scaling up AI at GSK. Information and Cyber Security Governance The Chief Digital and Technology Officer (CDTO) leads the Digital and Technology function, which includes the CISO and Cyber Security Office. The CDTO is the enterprise risk owner for our Information and Cyber Security principal risk, responsible for managing and reporting on the risk, and the enterprise risk plan. This plan includes a description of the risk, its context, our assessment and risk appetite, how we treat the risk and what actions we need to take to manage it in line with our corporate internal control framework. The CISO is responsible for risk coordination across the organisation, developing and overseeing the implementation of controls, and monitoring and reporting on the enterprise risk plan. Both the Board and the Audit & Risk Committee oversee our cyber security risk. The Risk Oversight and Compliance Council helps the Audit & Risk Committee to oversee the cyber security risks, and our strategies to address them. The CISO reports on cyber security risks throughout the year to the CDTO, Risk Oversight and Compliance Council and the Audit & Risk Committee. This reporting covers, external insights, key risk indicators, management actions, updates on implementing the enterprise risk plan, progress on the cyber maturity programme, and escalations The Cyber Security Office analyses potential cyber security incidents, supported by internal experts, and gives updates to the CISO. The CISO escalates any cyber incidents with potential for material impact to the Chief Compliance Officer and the CDTO, who in turn escalates to the GSK Leadership Team and Company Secretary, triggering review by the Disclosure Committee to determine materiality. Any material cyber security incidents are subsequently escalated to the Board and Audit & Risk Committee. Cyber Security Awareness, Training and Readiness Our cyber security awareness and training programmes include phishing simulations, monthly awareness campaigns and mandatory annual refreshers for all employees, new hires and high-risk roles. We run quarterly phishing simulation tests and related remedial trainings. We also offer optional training and an annual global event. These efforts aim to increase cyber security awareness and foster a culture that security is everyone’s responsibility. Also, we run periodic crisis simulation exercises for targeted functions to test our response to cyber security incidents. Compliance with various governmental cyber security regulations Our Cyber Security Office, guided by our General Counsel, works to stay abreast of emerging government regulations, trends, and compliance expectations regarding cyber security. As new regulatory guidance becomes available (including the U.S. Securities and Exchange Commission's rules on cyber security related disclosures), we respond with remedial compliance-related actions. 293 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Principal risks and uncertainties continued Supply continuity Risk definition The risk that GSK or our third parties potentially fail to deliver a continuous supply of compliant finished product or respond effectively to a crisis incident in a timely manner to recover and sustain critical supply operations. Risk impact .We recognise how important the continuity of supply of our products is to the patients who rely on them. Supply disruption can lead to: – Product shortages and product recalls – Regulatory intervention – Reputational harm – Lost sales revenue Consequently, we need sophisticated end-to-end supply chain management with robust crisis management and business continuity plans in place to respond. Context We operate our supply chains in a continually evolving, highly regulated environment. There is no single set of global regulations which governs the manufacture and distribution of medicines, and we must adhere to the requirements in all those markets in which we licence, sell or manufacture our products. We rely upon our internal Quality Management System and our Internal Control Framework to ensure we maintain our licence to operate. Our complex end-to-end supply chains often involve third party suppliers, from Active Pharmaceutical Ingredient (API) manufacturers and raw material suppliers through to Third Party Logistics Providers and contract engineering firms. We have integrated risk management into our sourcing and day to day business processes, with emphasis on our Third- Party oversight. External factors continued to challenge supply continuity in 2023. The difficulties with sourcing bioscience materials has eased through the year. There is a new constraint with third party sterile manufacturing capacity which increases global competition for contract manufacturing operations. We continue to operate our global supply chains in a rapidly changing geopolitical environment. Increasing nationalism and friction between the US and China creates divergence from global supply strategy. We have reacted to this by designing supply routes that de-risk sourcing decisions and use business continuity planning to mitigate and maintain supply continuity, e.g. dual sourcing for materials and adapting supply routes to meet regulatory expectations for both the commercial and late stage clinical supply chains. Our supply chain imperatives focus on accelerating innovation with the use of technology and data to transform the way we manufacture and supply our medicines and vaccines. We drive our competitive advantage through our long-term strategic partnership with R&D. We focus our talent on the skills needed for the future, addressing skills in new technologies and modalities. We have brought the Vaccines and Medicines supply chains together into one Global Supply Chain organisation to leverage the benefits of our highly skilled workforce. Continual business monitoring is in place to assess the sector-wide risk of the spread of industrial relations challenges arising from global cost of living pressures. Keeping our patients supplied with their medicines is our priority. Mitigating activities Risk management Our Medicines and Vaccine supply chains are set up to ensure sustainable global supply. The GSK Internal Control Framework drives our approach to risk management, and it has been designed to identify emerging new risks and support clear decision making. Risk oversight is managed through a hierarchy of Risk Management and Compliance Boards to assure risk mitigation (including identifying new and emerging threats). Inventory management Supply chain governance committees in Medicines and Vaccines closely monitor the inventory status and delivery of our products. Our core commercial cycle links supply chain forecasting with our commercial ambition. It is designed to reduce the risk of demand fluctuations and manage temporary shortages in supply. We periodically review each node of our supply chains to ensure we hold adequate safety stocks, whilst balancing working capital. We put particular emphasis on mitigating supply risks associated with medically-critical, high- revenue products and new product launches, for example using dual sourcing for key products or APIs. We use the monthly Performance Management Process across our supply chains to monitor business activity and highlight adverse trends in supply, operations, budget and workforce capability. Business continuity Crisis management and business continuity plans are in place across our supply chains, which include authorised response and recovery strategies, key areas of responsibility and clear communication routes. We regularly use business continuity plans to manage potential supply disruptions. Our manufacturing sites have crisis management plans in place. These plans are tested at least annually to ensure maintenance of core skills in crisis management. 294 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Shareholder information Share capital and control Details of our issued share capital and the number of shares held in Treasury as at 31 December 2023 can be found in Note 37 to the financial statements, ‘Share capital and share premium account’. Our ordinary shares are listed on the London Stock Exchange (LSE) and are also quoted on the New York Stock Exchange (NYSE) in the form of American Depositary Shares (ADS). Each ADS represents two Ordinary Shares. For details of listed debt and where it is listed refer to Note 30 to the financial statements, ‘Net debt’. Holders of Ordinary Shares and ADS are entitled to receive dividends (when declared) and a copy of the company’s Annual Report (if elected). They are also entitled to attend, speak, appoint proxies and exercise voting rights at general meetings of the company There are no restrictions on the transfer, or limitations on the holding, of Ordinary Shares and ADS and no requirements to obtain approval prior to any transfers. No Ordinary Shares or ADS carry any special rights with regard to control of the company and there are no restrictions on voting rights. Major shareholders have the same voting rights per share as all other shareholders. There are no known arrangements under which financial rights are held by a person other than the holder of the shares and no known agreements on restrictions on share transfers or on voting rights. Shares acquired through the Group’s employee share plans rank equally with the other shares in issue and have no special rights. The trustees of our Employee Share Ownership Plan Trusts have waived their rights to dividends on shares held by those Trusts. Demerger of Haleon and Share Consolidation As reported previously, on 18 July 2022 the company completed the demerger of the Consumer Healthcare business from the Group. More details can be found on www.gsk.com/en-gb/ haleon-cmd-to-demerger-archive. On 19 July 2022, shareholders received four new GSK plc shares of nominal value of 31 1/4 pence each for every five GSK plc shares of nominal value of 25 pence each. The Group reduced its share holding in Haleon plc during the course of the financial year ended 31 December 2023 to 7.4%. More information can be found in Note 22 Current Equity Investments. On 17 January 2024, the Group reduced its shareholding by 3.2%, GSK now holds approximately 385 million ordinary shares in Haleon plc representing over 4.0% of the issued share capital of Haleon. More information can be found in Note 48 Post Balance Sheet Events. Exchange controls and other limitations affecting holders Other than certain economic sanctions, which may be in force from time to time, there are currently no applicable laws, decrees or regulations in force in the UK restricting the import or export of capital or restricting the remittance of dividends or other payments to holders of the company’s shares who are non-residents of the UK. Similarly, other than certain economic sanctions which may be in force from time to time, there are no limitations relating only to non-residents of the UK under English law or the company’s Articles of Association on the right to be a holder of, and to vote in respect of, the company’s shares. Interests in voting rights Other than as stated below, as far as as the company is aware, there are no persons with significant direct or indirect holdings in the company. Information provided to the company pursuant to the FCA's Disclosure Guidance and Transparency Rules (DTR 5) is published on a Regulatory Information Service and on the company’s website, gsk.com. The company has received notifications in accordance with DTR 5 of the following notifiable interests in the voting rights in the company’s issued share capital: 31 December 2023 23 February 2024 No. of voting rights 231,975,400(2) 253,464,108 (3) Percentage No. of of total voting voting rights(1) rights 5.69 % 231,975,400(2) 5.04 % 253,464,108(3) Percentage of total voting rights(1) 5.69 % 5.04 % BlackRock, Inc. Dodge & Cox (1) Percentage of total voting rights at the date of notification to the company. (2) Comprising an indirect interest in 229,134,683 Ordinary Shares and a holding of 2,840,717 Qualifying Financial Instruments (Contracts for Difference). (3) Comprising an indirect interest in 99,377,874 Ordinary Shares and 154,086,234 ADS. The company has not acquired or disposed of any interests in its own shares during the period under review. Share buy-back programme The Board has been authorised to issue and allot Ordinary Shares under Article 9 of the company’s Articles of Association. The power under Article 9 and the authority for the company to make purchases of its own shares are subject to shareholder authorities which are sought on an annual basis at our Annual General Meeting (AGM). Any shares purchased by the company may be cancelled, held as Treasury shares or used for satisfying share options and grants under the Group's employee share plans. Our programme covers purchases of shares for cancellation or to be held as Treasury shares, in accordance with the authority renewed by shareholders at the AGM in May 2023, when the company was authorised to purchase a maximum of just over 409 million shares. In determining specific share repurchase levels, the company considers the development of free cash flow during the year. No Treasury shares have been purchased since 2014. Details of shares purchased, cancelled, held as Treasury shares and subsequently transferred from Treasury to satisfy awards under the Group’s employee share plans are disclosed in Note 37 to the financial statements, ‘Share capital and share premium account’. The company confirms that it does not currently intend to make any market purchases in 2024. The company will continue to review the potential for future share buy-backs in line with its usual annual cycle and subject to return and ratings criteria. 295 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Share price trend in the three years ended 31 December 2023 Shareholder information continued Share capital and control continued Market capitalisation The market capitalisation, based on shares in issue excluding Treasury shares, of GSK at 31 December 2023 was £62.5 billion. At that date, GSK was the 8th largest company by market capitalisation in the FTSE index. Share price At 1 January At 31 December Increase/(decrease) High during the year Low during the year 2023 £ 14.51 14.50 (0.06) % 15.36 13.16 2022 £ 16.25 14.38 (12) % 18.31 12.96 2021 £ 13.42 16.07 20 % 16.19 11.91 The table above sets out middle market closing prices. The company’s share price decreased by (0.06)% in 2023. This compares with a decrease in the FTSE 100 index of 12% during the year. The middle market closing share price on 23 February 2024 was £16.72 . Nature of trading market The following table sets out, for the periods indicated, the high and low middle market closing prices for the company’s Ordinary Shares on the LSE and for the ADS on the NYSE. Ordinary Shares UK£ per share ADS US$ per share February 2024* January 2024 December 2023 November 2023 October 2023 September 2023 Quarter ended 31 December 2023 Quarter ended 30 September 2023 Quarter ended 30 June 2023 Quarter ended 31 March 2023 Quarter ended 31 December 2022 Quarter ended 30 September 2022 Quarter ended 30 June 2022 Quarter ended 31 March 2022 Year ended 31 December 2021 Year ended 31 December 2020 Year ended 31 December 2019 * to 23 February 2024 High 16.78 15.82 14.62 14.26 15.21 13.36 15.21 15.36 15.23 15.03 14.92 18.23 18.31 17.27 16.19 14.68 18.19 Low 15.86 14.80 14.19 13.82 14.33 13.74 13.82 13.16 13.46 13.77 13.20 12.96 16.72 15.01 13.80 12.92 14.36 High 33.31 40.10 37.10 34.17 37.56 38.07 37.56 38.07 38.32 36.43 37.92 44.53 47.70 47.66 44.44 39.17 47.32 Low 31.90 37.51 35.88 35.99 34.56 34.41 34.17 33.81 33.60 33.50 30.00 28.67 41.98 40.17 38.13 33.42 37.83 296 UK£US$UK Share Price (UK£)US Share Price (US$)Jan-21Jan-22Jan-237810111213141617181927323641455054596368Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Shareholder information continued Analysis of shareholdings at 31 December 2023 Holding of shares Up to 1,000 1,001 to 5,000 5,001 to 100,000 100,001 to 1,000,000 Over 1,000,000 Held by Institutional and corporate holders Individuals and other corporate bodies Guaranty Nominees Limited (ADR programme) Held as Treasury shares by GSK Number of accounts % of total accounts % if total shares Number of shares 46,607 11,313 2,843 654 328 75.48 18.32 4.60 1.06 0.53 0.32 0.55 1.21 5.31 13,747,981 23,914,101 52,308,743 229,085,155 92.60 3,993,090,003 61,745 100.00 100.00 4,312,145,983 2,153 59,590 1 1 3.49 96.51 0.00 0.00 61.86 2,667,435,551 13.86 597,606,148 19.71 4.57 850,036,115 197,068,169 61,745 100.00 100.00 4,312,145,983 JP Morgan Chase Bank NA is the Depositary for the company’s American Depositary Receipt (ADR) programme. The company’s ADS are listed on the NYSE. Ordinary Shares representing the company’s ADR programme, which is managed by the Depositary, are registered in the name of Guaranty Nominees Limited. At 23 February 2024, Guaranty Nominees Limited held 832,929,801 Ordinary Shares representing 20.23% of the issued share capital (excluding Treasury shares). At 23 February 2024, the number of holders of Ordinary Shares in the US was 842 with holdings of 689,588 Ordinary Shares, and the number of registered holders of ADS was 15,511 with holdings of 416,464,900 ADS. Certain of these Ordinary Shares and ADS were held by brokers or other nominees. As a result, the number of holders of record or registered holders in the US is not representative of the number of beneficial holders or of the residence of beneficial holders. Dividends The company pays dividends quarterly and continues to return cash to shareholders through its dividend policy. Dividends remain an essential component of total shareholder return and GSK recognises the importance of dividends to shareholders. (3) Adjusted for the Share Consolidation (2022 only; prior years have not been adjusted). (4) The Q4 2023 ordinary dividend receivable by ADS holders will be calculated based on the exchange rate on 9 April 2024. The cumulative dividend receivable by ADS holders for Q1, Q2 and Q3 2023 was £1.06. On 23 June 2021, at the GSK Investor Update, GSK set out that from 2022 a progressive dividend policy will be implemented guided by a 40 to 60 percent pay-out ratio through the investment cycle. The dividend policy, the total expected cash distribution, and the respective dividend pay-out ratios for GSK remain unchanged. Dividends per share The table below sets out the dividend per share and per ADS for the last five years. The dividend per ADS is translated into US dollars at applicable exchange rates. Year 2023 2022 2021 2020 2019 pence 58(2) 61.25(3) 80 80 80 US$(1) -(4) 2.00 2.16 2.12 2.01 (1) An annual fee of $0.03 per ADS (or $0.0075 per ADS per quarter) will be charged by the Depositary. The amounts shown are the dividends paid per ADS before the annual fee is charged. (2) Dividends declared and paid in respect of 2023 were 14p per share for Q1 2023, 14p per share for Q2 2023 and 14p per share for Q3 2023. A dividend of 16p per share has been declared for Q4 2023. The expected dividend for 2024 is 60p per Ordinary Share. Details of the dividends declared, the amounts and the payment dates are given in Note 16 to the financial statements, ‘Dividends’. 2024 Dividend calendar Quarter Q4 2023 Q1 2024 Q2 2024 Q3 2024 Q4 2024 Ex-dividend date 22 February 2024 ADS Ex- dividend date 22 February 2024 Record date Payment date 11 April 2024 23 February 2024 16 May 2024 15 August 2024 14 November 2024 16 May 2024 16 August 2024 15 November 2024 17 May 2024 16 August 2024 15 November 2024 20 February 2025 21 February 2025 21 February 2025 11 July 2024 10 October 2024 9 January 2025 10 April 2025 297 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Shareholder information continued Financial calendar 2024 Event Quarter 1 results announcement Annual General Meeting Quarter 2 results announcement Date 1 May 2024 8 May 2024 31 July 2024 Quarter 3 results announcement 30 October 2024 Preliminary/Quarter 4 Results announcement 5 February 2025 Annual Report publication Annual Report distribution February/March 2024 March 2024 Information about the company, including the share and ADS price, is available on our website at gsk.com. Information made available on the website does not constitute part of this Annual Report. Stock Exchange announcement notifications We provide shareholders with a service to receive automatic email notifications when we publish a stock exchange announcement. To receive email notifications, please sign up for announcements at gsk.com in the Investors section. Annual General Meeting 2024 Our Annual General Meeting (AGM) will be held at 2.30pm (UK time) on Wednesday, 8 May 2024 at the Royal Lancaster London, Lancaster Terrace, London W2 2TY and will also be broadcast live for you to join electronically. The AGM is the company’s principal forum for communication with private shareholders. In addition to the formal AGM business, there will be a presentation by the CEO on the performance of the Group and its future development. There will be an opportunity for questions to be asked of the Board and Chairs of the Board’s Committees will be available to take questions relating to their roles. Further details on how to access the AGM electronically or attend in person, ask questions and vote, can be found in the notice of Annual General Meeting 2024 (AGM Notice) which will be made available on our website at gsk.com on or around 25 March 2024. Investors holding shares through a nominee service should arrange with that service for them to be appointed as a proxy in respect of their shareholding to attend and vote at the meeting electronically. Results announcements Results announcements are issued to the LSE and are available on its news service. They are also sent to the US Securities and Exchange Commission (SEC) and the NYSE, issued to the media and made available on our website. Financial reports The company publishes an Annual Report which is made available on our website from the date of publication. Shareholders may elect to receive notification by email of the publication of Annual Reports by registering on www.shareview.co.uk, and may also elect to receive a printed copy of the Annual Report by contacting our registrar, Equiniti Limited. Copies of previous Annual Reports are available on our website. Printed copies can also be obtained from our registrar (see page 301 for the contact details). ADS holders wishing to attend the meeting electronically should refer to the AGM Notice for details on how to request a proxy appointment from the Depositary, JP Morgan Chase Bank NA. This will enable them to attend, ask questions and vote electronically on the business to be transacted at the meeting. ADS holders are reminded that if they do not instruct the Depositary as to the way in which the shares represented by their ADS should be voted by completing and returning the voting card provided by the Depositary, their shares will not be voted. Documents on display The Articles of Association of the company and Directors’ service contracts or, where applicable, letters of appointment between Directors and the company or any of its subsidiaries (and any side letters relating to severance terms and pension arrangements) are available for inspection at the company’s registered office and will be made available for inspection at the AGM. 298 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Shareholder information continued Tax information for shareholders A summary of certain UK tax and US federal income tax consequences for holders of shares and ADS who are citizens of the UK or the US is set out below. It is not a complete analysis of all the possible tax consequences of the purchase, ownership or sale of these securities. It is intended only as a general guide. Holders are advised to consult their advisers with respect to the tax consequences of the purchase, ownership or sale of their shares or ADS and the consequences under state and local tax laws in the US and the implications of the current UK/US tax conventions. US holders of ADS generally will be treated as the owners of the underlying shares for the purposes of the current UK/US double taxation conventions relating to income and gains (Income Tax Convention), estate and gift taxes (Estate and Gift Tax Convention), and for the purposes of the Internal Revenue Code of 1986, as amended. UK shareholders This summary only applies to a UK resident shareholder that holds shares as capital assets. Taxation of dividends For the 2023/24 UK tax year, UK resident individuals are entitled to a dividend tax allowance of up to £1,000, so that the first £1,000 of dividends received in a tax year will be free of tax. Dividends in excess of this allowance will be taxed at 8.75% for basic rate taxpayers, 33.75% for higher rate taxpayers and 39.35% for additional rate taxpayers. Note that from 6 April 2024 the dividend allowance will be reduced to £500. UK resident shareholders that are corporation taxpayers should note that dividends payable on ordinary shares are generally entitled to exemption from corporation tax. Taxation of capital gains UK resident shareholders may be liable for UK tax on gains on the disposal of shares or ADS. For disposals by individuals in the 2023/24 UK tax year, a taxable capital gain accruing on a disposal of shares or ADS will be taxed at 10% for basic rate taxpayers, or 20% if, after all allowable deductions, the individual’s taxable income for the year exceeds the basic rate income tax banding. Note this is following the use of any exemptions available to the individual taxpayer such as the annual exempt amount. Corporation taxpayers may be entitled to an indexation allowance which applies to reduce capital gains to the extent that such gains arise due to inflation. Indexation allowance may reduce a chargeable gain but will not create an allowable loss. For assets acquired on or before 1 January 2018, legislation in the Finance Act 2018 freezes the level of indexation allowance that is given in calculating a company’s chargeable gains at the value that would apply to the disposal of an asset in December 2017. For assets acquired from 1 January 2018 onwards, legislation in the Finance Act 2018 removes any indexation allowance on disposal. Inheritance tax Individual (UK-domiciled or otherwise) shareholders may be liable to UK inheritance tax on the transfer of shares or ADS. Exposure to a UK inheritance tax charge typically occurs on the death of the asset owner. However, transfers of shares (other than commercial sales) within seven years of death remain relevant to any inheritance tax exposure at death. Further, transfers to a trust arrangement during lifetime can give rise to an immediate inheritance tax charge. Tax may be charged on the amount by which the value of the shareholder’s estate is reduced as a result of any transfer by way of lifetime gift or other disposal at less than full market value. In the case of a bequest on death, tax may be charged on the value of the shares at the date of the shareholder’s death. Where an exposure to UK inheritance tax and US estate or gift tax exists, careful planning must be undertaken to understand the opportunity to utilise the US/UK Estate and Gift Double Tax Convention to manage tax credits and avoid double taxation. The overall exposure will be dependent on the specific circumstances of each situation and it is also important to note that tax charges may arise in other jurisdictions. Bespoke advice tailored to an individual’s personal circumstances should therefore be obtained from a tax professional. Stamp duty and stamp duty reserve tax UK stamp duty and/or stamp duty reserve tax (SDRT) will, subject to certain exemptions, be payable on the transfer of shares at a rate of 0.5% (rounded up to the nearest £5 in the case of stamp duty) of the consideration for the transfer. Notwithstanding this, provided that an instrument is executed in pursuance of the agreement that gave rise to the charge to SDRT and that instrument is stamped within six years of the agreement (including being stamped as exempt) any SDRT charge should be cancelled and any SDRT which has already been paid will be repaid. Where listed shares are transferred to a company connected to the transferor the chargeable consideration will be deemed to be not less than the market value of the shares transferred. This market value override also applies where non-listed shares are transferred to a company connected to the transferor where the consideration includes an issue of shares. US shareholders This summary only applies to a shareholder (who is a citizen or resident of the US or a domestic corporation or a person that is otherwise subject to US federal income tax on a net income basis in respect of the shares or ADS) that holds shares or ADS as capital assets, is not resident in the UK for UK tax purposes and does not hold shares for the purposes of a trade, profession or vocation that is carried on in the UK through a branch or agency. The summary also does not address the tax treatment of holders that are subject to special tax rules, such as banks, tax- exempt entities, insurance companies, dealers in securities or currencies, persons that hold shares or ADS as part of an integrated investment (including a ‘straddle’) comprised of a share or ADS and one or more other positions, and persons that own (directly, indirectly or constructively) 10% or more of the company’s stock (by vote or value), nor does it address tax treatment that may be applicable as a result of international income tax treaties. 299 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Shareholder information continued Tax information for shareholders continued Taxation of dividends The gross amount of dividends received is treated as foreign source dividend income for US tax purposes. It is not eligible for the dividend received deduction allowed to US corporations. Dividends on ADS are payable in US dollars; dividends on Ordinary Shares are payable in sterling. Dividends paid in sterling will be included in income in the US dollar amount calculated by reference to the exchange rate on the day the dividends are received by the holder. Subject to certain exceptions for short-term or hedged positions, an individual eligible US holder will be subject to US taxation at a maximum federal rate of 23.8% plus applicable state and local tax in respect of qualified dividends. A qualified dividend as defined by the US Internal Revenue Service (IRS) is a dividend that meets the following criteria: 1. It must be issued by a US corporation, a corporation incorporated in a US possession, or a corporation that is eligible for the benefits of a comprehensive income tax treaty deemed satisfactory, as published by the IRS. 2. The dividends are not of a type listed by the IRS as dividends that do not qualify. 3. The required dividend holding period has been met. The shares must have been owned by you for more than 60 days of the ‘holding period’ – which is defined as the 121-day period that begins 60 days before the ex-dividend date, or the day in which the stock trades without the dividend priced in. For example, if a stock’s ex-dividend date is 1 October, the shares must be held for more than 60 days in the period between 2 August and 30 November of that year in order to count as a qualified dividend. Dividends that are not qualified are subject to taxation at the US federal graduated tax rates, at a maximum rate of 40.8%. Some types of dividends are automatically excluded from being qualified dividends, even if they meet the other requirements. These include (but are not limited to): – Capital gains distributions – Dividends on bank deposits – Dividends held by a corporation in an Employee Stock Ownership Plan (ESOP) – Dividends paid by tax-exempt corporations. US state and local tax rates on qualified and non-qualified dividends may vary and would be assessed in addition to the federal tax rates communicated above. Taxation of capital gains Generally, US holders will not be subject to UK capital gains tax, but will be subject to US tax on capital gains realised on the sale or other disposal of shares or ADS. Such gains will be long- term capital gains (subject to reduced rates of taxation for individual holders) if the shares or ADS were held for more than one year, from the date the shares were vested/released. Short- term capital gains can be subject to taxation of rates of up to 40.8%, whereas long-term capital gains may be subject to rates of up to 23.8%. State and local tax rates on capital gains may also apply. Information reporting and backup withholding Dividends and payments of the proceeds on a sale of shares or ADS, paid within the US or through certain US-related financial intermediaries, are subject to information reporting and may be subject to backup withholding unless the US holder is a corporation or other exempt recipient or provides a taxpayer identification number and certifies that no loss of exemption has occurred. Non-US holders generally are not subject to information reporting or backup withholding, but may be required to provide a certification of their non-US status in connection with payments received. Any amounts withheld will be allowed as a refund or credit against a holder’s US federal income tax liability provided the required information is furnished to the IRS. Estate and gift taxes Under the Estate and Gift Tax Convention, a US shareholder is not generally subject to UK inheritance tax. However, a US holder may be subject to US federal estate and gift tax. Stamp duty UK stamp duty and/or SDRT will, subject to certain exemptions, be payable on any transfer of shares to the ADS custodian or depositary at a rate of 1.5% of the amount of any consideration provided (if transferred on sale), or their value (if transferred for no consideration). However, no stamp duty or SDRT should be payable on the transfer of, or agreement to transfer an ADS or on transfers within the clearance service. Notwithstanding the above, where the clearance service operator has made an election under s97A Finance Act 1986, broadly the 1.5% stamp duty/SDRT charge should not arise on the transfer into the clearance service, but transfers to, and within, the system (where there is a change in beneficial ownership) would attract a 0.5% charge. Demerger and share consolidation A summary of certain UK and US tax consequences in respect of the demerger of Haleon plc and the consolidation of the company's share capital, relevant to the company’s shareholders who are resident (or, in the case of individuals, resident and domiciled) in the UK for UK tax purposes or who are citizens of or resident in the US for US tax purposes, is set out in Part 6 of the circular in relation to the Demerger and the Share Consolidation published on 1 June 2022 (Circular) (pages 83 to 89). The Circular, along with other information regarding the demerger and share consolidation can be found at gsk.com in the demerger section. Further information on the tax base cost allocation to assist UK shareholders apportion their base cost between their GSK plc shares and Haleon plc shares for UK capital gains tax purposes following the demerger, including a worked example, can be found in the Tax section at gsk.com in the demerger section. 300 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures Shareholder services and contacts Registrar The company’s registrar is: Equiniti Limited Aspect House, Spencer Road, Lancing, BN99 6DA www.shareview.co.uk Tel: +44 (0)371 384 2991* Equiniti provides a range of services for shareholders: Service What it offers How to participate Dividend Reinvestment Plan (DRIP) As an alternative to receiving cash dividends you may choose to reinvest your dividends to buy more GSK shares. Dividend payment direct to your bank account (bank mandate) All dividends are paid directly into your bank or building society account. To receive your cash dividends, you must provide Equiniti with your bank or building society account details. This is a quick and secure method of payment. A DRIP election form, Terms and Conditions and information on fees can be downloaded from www.shareview.co.uk or requested by contacting Equiniti. A dividend bank mandate form can be downloaded from www.shareview.co.uk or requested by contacting Equiniti. Dividend payment direct to bank account for overseas shareholders (Overseas Payment Service) Equiniti can convert your dividend into your local currency and send it direct to your local bank account. The Overseas Payment Service is available in approximately 100 countries worldwide. More information on the Overseas Payment Service (including information on fees) can be found at www.shareview.co.uk or by contacting Equiniti. Electronic communications Shareview portfolio service Deduplication of publications or mailings Share dealing service† (please note that market trading hours are from 8.00am to 4.30pm UK time, Monday to Friday (excluding public holidays in England and Wales)) Corporate Sponsored Nominee Account Shareholders may elect to receive electronic notifications of company communications including our Annual Report, dividend payments, dividend confirmations and the availability of online voting for all general meetings. Each time GSK publishes shareholder documents you will receive an email containing a link to the document or relevant website. This enables you to create a free online portfolio to view your share balance and movements, update your address and dividend payment instructions and register your votes for our general meetings. If you receive duplicate copies of mailings, you may have more than one account. Please contact Equiniti and they will arrange for your accounts to be merged into one for your convenience and to avoid waste and unnecessary costs. Shareholders may trade shares, either held in certificated form or in our Corporate Sponsored Nominee, online, by telephone or via postal dealing service provided by Equiniti Financial Services Limited. This is a convenient way to manage your shares without requiring a share certificate. The service provides a facility for you to hold your shares in a nominee account sponsored by the company. You will continue to receive dividend payments and can attend and vote at the company’s general meetings. Shareholders’ names do not appear on the publicly available share register and the service is free to join. Please register at www.shareview.co.uk. Please register at www.shareview.co.uk. Please contact Equiniti. More information on the share dealing service (including information on fees) can be found at www.shareview.co.uk/dealing For online transactions, please log on to: www.shareview.co.uk/dealing. For telephone transactions, please call: 0345 603 7037 (in the UK) or +44 (0)345 603 7037 (outside the UK). Lines are open from 8.00am to 4.30pm UK time, Monday to Friday (excluding UK public holidays). For postal transactions, please call: 0371 384 2991* to request a dealing form. An application form can be requested from www.shareview.co.uk or by contacting Equiniti. Individual Savings Accounts (ISAs)† Equiniti Financial Services Limited provide the EQi Flexible ISA to hold GSK shares. Details (including information on fees) are available from www.eqi.co.uk or can be requested by calling the Equiniti Customer Experience Team on 0345 0700 720. Lines are open 8:00am to 5:30pm, UK time Monday to Friday (excluding UK public holidays). * Lines are open from 8.30am to 5.30pm, UK time Monday to Friday (excluding public holidays in England and Wales). Please use the country code when dialling from outside the UK. † The provision of share dealing details is not intended to be an invitation or inducement to engage in an investment activity. Advice on share dealing should be obtained from a stockbroker or independent financial adviser. 301 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Shareholder services and contacts continued ADS Depositary The ADR programme is administered by JPMorgan Chase Bank, N.A.: Regular Correspondence: EQ Shareowner Services P.O. Box 64504 St. Paul, MN 55164-0504 Delivery of Stock Certificates and Overnight Mail: EQ Shareowner Services 1110 Centre Pointe Curve, Suite 101 Mendota Heights, MN 55120-4100 shareowneronline.com/informational/contact-us/ From the US: +1 877 353 1154 From outside the US: +1 651 453 2128 The Depositary also provides Global Invest Direct, a direct ADS purchase/sale and dividend reinvestment plan for ADS holders. For details on how to enrol, please visit www.adr.com or call the above helpline number to obtain an enrolment pack. Contacts Investor relations Investor relations may be contacted as follows: UK 980 Great West Road Brentford, Middlesex, TW8 9GS Tel: +44 (0)20 8047 5000 US 2929 Walnut Street Philadelphia PA 19104 Tel: +1 888 825 5249 (US toll free) Tel: +1 215 751 4000 (outside the US)­ GSK Response Center Tel: +1 888 825 5249 (US toll free) Tel: +1 215 751 4600 (outside the US) Share scam alert If you receive an unsolicited telephone call offering to sell or buy your shares, please take extra care. The caller may be part of a highly organised financial scam. If you are a UK shareholder, please contact the Financial Conduct Authority at www.fca.org.uk/consumers or on its consumer helpline: Tel: 0800 111 6768 (in the UK)* Tel: +44 207 066 1000 (outside the UK)* * Lines are open from 8.00am to 6.00pm, UK time, Monday to Friday, except UK public holidays, and 9.00am to 1.00pm on Saturdays. Donating shares to Save the Children In 2013, GSK embarked on an ambitious global partnership with Save the Children to share our expertise and resources with the aim of finding innovative ways to reduce the number of children dying from preventable diseases. Shareholders with a small number of shares, the value of which makes it uneconomical to sell, may wish to consider donating them to Save the Children. Donated shares will be aggregated and sold on behalf of Save the Children who will use the funds raised to help them reach the above goal.† To obtain a share donation form, please contact our registrar, Equiniti, which is managing the donation and sale of UK shares to Save the Children free of charge. † The provision of share dealing details is not intended to be an invitation or inducement to engage in an investment activity. Advice on share dealing should be obtained from a stockbroker or independent financial adviser. 302 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued US law and regulation A number of provisions of US law and regulation apply to the company because our shares are quoted on the NYSE in the form of ADS. NYSE rules In general, the NYSE rules permit the company to follow UK corporate governance practices instead of those applied in the US, provided that we explain any significant variations. This explanation is contained in our Form 20-F, which can be accessed from the SEC's EDGAR database or via our website. NYSE rules require us to file annual and interim written affirmations concerning our Audit & Risk Committee (ARC) and our statement on significant differences in corporate governance. Sarbanes-Oxley Act of 2002 Following a number of corporate and accounting scandals in the US, Congress passed the Sarbanes-Oxley Act of 2002. Sarbanes-Oxley is a wide-ranging piece of legislation concerned largely with financial reporting and corporate governance. As recommended by the SEC, the company has an established Disclosure Committee. The Committee reports to the CEO, the CFO and to the ARC. It is chaired by the Company Secretary and its members consist of senior managers from finance, legal, corporate communications and investor relations. Where appropriate, external legal counsel, the external auditors, our sponsor bank, and internal experts are invited to attend the Disclosure Committee’s meetings periodically. The Committee has responsibility for considering the materiality of information and, on a timely basis, determining the disclosure of that information. It has responsibility for the timely filing of reports with the SEC and the formal review of the Annual Report and the Annual Report on Form 20-F. In 2023, the Committee met 17 times, including for the purpose of receiving relevant and appropriate training. Sarbanes-Oxley requires that the Annual Report on Form 20-F contains a statement as to whether a member of the ARC is an audit committee financial expert, as defined in rules under Sarbanes-Oxley. Such a statement for the relevant members of the ARC (Charles Bancroft) is included in the Board Committee information area of the Corporate Governance report on page 118 and in his biography on page 109. Additional disclosure requirements arise under section 302 and section 404 of Sarbanes-Oxley in respect of disclosure controls and procedures and internal control over financial reporting. Section 302: Corporate responsibility for financial reports Sarbanes-Oxley requires the CEO and the CFO to complete formal certifications, confirming that: – they have each reviewed the Annual Report on Form 20-F; – based on their knowledge, the Annual Report on Form 20-F contains no material misstatements or omissions; – based on their knowledge, the financial statements and other financial information fairly present, in all material respects, the financial condition, results of operations and cash flows as of the dates, and for the periods, presented in the Annual Report on Form 20-F; – they are responsible for establishing and maintaining disclosure controls and procedures that ensure that material information is made known to them, and have evaluated the effectiveness of these controls and procedures as at the year end, the results of such evaluation being contained in the Annual Report on Form 20-F; – they are responsible for establishing and maintaining internal control over financial reporting that provides reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles; – they have disclosed in the Annual Report on Form 20-F any changes in internal controls over financial reporting during the period covered by the Annual Report on Form 20-F that have materially affected, or are reasonably likely to affect materially, the company’s internal control over financial reporting; and – they have disclosed, based on their most recent evaluation of internal control over financial reporting, to the external auditor and the ARC, all significant deficiencies and material weaknesses in the design or operation of internal controls over financial reporting which are reasonably likely to affect adversely the company’s ability to record, process, summarise and report financial information, and any fraud (regardless of materiality) involving persons that have a significant role in the company’s internal control over financial reporting. The Group has carried out an evaluation under the supervision and with the participation of its management, including the CEO and CFO, of the effectiveness of the design and operation of the Group’s disclosure controls and procedures as at 31 December 2023. There are inherent limitations to the effectiveness of any system of disclosure controls and procedures, including the possibility of human error and the circumvention or overriding of the controls and procedures. Accordingly, even effective disclosure controls and procedures can only provide reasonable assurance of achieving their control objectives. 303 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued US law and regulation continued The CEO and CFO expect to complete these certifications and report their conclusions on the effectiveness of disclosure controls and procedures in March 2024, following which the certifications will be filed with the SEC as part of our Group’s Annual Report on Form 20-F. Section 404: Management’s annual report on internal control over financial reporting In accordance with the requirements of section 404 of Sarbanes-Oxley, the following report is provided by management in respect of the company’s internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the US Securities Exchange Act of 1934, as amended (the Exchange Act)): – Management is responsible for establishing and maintaining adequate internal control over financial reporting for the Group. Internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with IFRS. – Management conducted an evaluation of the effectiveness of internal control over financial reporting based on the framework, Internal Control – Integrated Framework (2013) issued by the Committee of Sponsoring Organisations of the Treadway Commission (COSO). – There have been no changes in the Group’s internal control over financial reporting during 2023 that have materially affected, or are reasonably likely to materially affect, the Group’s internal control over financial reporting. – Management has assessed the effectiveness of internal control over financial reporting as at 31 December 2023 and its conclusion will be filed as part of the Group’s Annual Report on Form 20-F. – Deloitte LLP, which has audited the consolidated financial statements of the Group for the year ended 31 December 2023, has also assessed the effectiveness of the Group’s internal control over financial reporting under Auditing Standard 2201 of the Public Company Accounting Oversight Board (United States). Their audit report will be filed with the Group’s Form 20-F. Section 13(r) of the Exchange Act Section 13(r) of the Exchange Act requires issuers to make specific disclosure in their annual reports of certain types of dealings with Iran, including transactions or dealings with government-owned or-controlled entities, as well as dealings with entities sanctioned for activities related to terrorism or proliferation of weapons of mass destruction, even when those activities are not prohibited by US law and do not involve US persons. The Group exports certain medicines to Iran, via sales by non- US entities that are not subsidiaries of a US entity to a distributor in Iran pursuant to a specific licence issued by the Office of Foreign Assets Control. The Group does not regularly receive information regarding the identity of the distributor's downstream customers and intermediaries in Iran, and it is possible that these parties include entities, such as hospitals and pharmacies, that are owned directly or indirectly by the Iranian government or by persons or entities sanctioned in connection with terrorism or proliferation activities. As the Group does not regularly receive information regarding the identity of its distributor's downstream customers and intermediaries it cannot establish the proportion of gross revenue or sales potentially attributable to entities affiliated with the Iranian government or parties sanctioned for disclosable activities. As a result, the Group is reporting the entire gross revenues (£16.89 million) and net profits (£8.42 million) from the Group's sales to Iran in 2023. Some hospitals or other medical facilities in Lebanon may be affiliated with or controlled by Hezbollah or other groups that are designated by the United States pursuant to Executive Order 13224. Again, the Group does not deal directly with such hospitals or facilities and instead sells through distributors. The Group is unable to establish the proportion of gross revenue or sales potentially attributable to reportable activities. As a result, the Group is reporting the entire gross revenues (£6.02 million) and net losses (£4.2 million) from the Group's sales to Lebanon in 2023. In addition to Section 13(r) of the Exchange Act, US law generally restricts dealings by US persons and dealings that otherwise are subject to US jurisdiction with certain countries or territories that are subject to comprehensive sanctions, currently Crimea, Cuba, the so-called Donetsk People's Republic, Iran, the so-called Luhansk People's Republic, North Korea and Syria, as well as with the Government of Venezuela (though not with the country of Venezuela as a whole). The Group engages in some activity in certain such jurisdictions having assessed applicable licences and exemptions While we believe the Group complies with all applicable US sanctions in all material respects, such laws are complex and continue to evolve rapidly. 304 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Donations to political organisations and political expenditure As a result, the definitions may cover legitimate business activities not in the ordinary sense considered to be political donations or political expenditure, nor are they designed to support any political party or independent election candidate. Therefore, notwithstanding our policy, and while we do not intend to make donations to any EU political parties or organisations, nor to incur any EU political expenditure, we annually seek shareholder authorisation for any inadvertent expenditure. The authority is a precautionary measure to ensure that the company and its subsidiaries do not inadvertently breach the legislation. This authorisation process, for expenditure of up to £100,000 each year, dates back to the AGM held in May 2001, following the introduction of the Political Parties, Elections and Referendums Act 2000. The authority has since been renewed annually. To ensure a consistent approach to political contributions across the Group, in 2009 a global policy was introduced to voluntarily stop all corporate political contributions. In the period from 1 January 2009 to 31 December 2023, the Group has not made any political donations to EU or non-EU organisations. Notwithstanding the introduction of this policy, in accordance with the Federal Election Campaign Act in the US, we continue to support an employee-operated Political Action Committee (PAC) that facilitates voluntary political donations by eligible GSK employees. The PAC is not controlled by GSK. Decisions on the amounts and recipients of contributions are governed by the PAC Board of Directors. Contributions to the PAC are made by participating eligible employees exercising their legal right to pool their resources and make political contributions, which are subject to strict limitations under US law. In 2023, a total of US$325,750 (2022: US$360,950) was donated to political organisations by the GSK employee PAC. English law requires prior shareholder approval for political contributions to EU political parties and independent election candidates as well as for any EU political expenditure. The definitions of political donations, political expenditure and political organisations used in the legislation are, however, quite broad. In particular, the definition of EU political organisations may extend to bodies such as those concerned with policy review, law reform, the representation of the business community and special interest groups such as those concerned with the environment, which the company and its subsidiaries might wish to support. 305 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies In accordance with Section 409 of the Companies Act 2006 a full list of subsidiaries, associates, joint ventures and joint arrangements, the address of the registered office and effective percentage of equity owned, as at 31 December 2023 are disclosed below. Unless otherwise stated the share capital disclosed comprises ordinary shares which are indirectly held by GSK plc. The percentage held by class of share is stated where this is less than 100%. Unless otherwise stated, all subsidiary companies have their registered office and are tax resident in their country of incorporation. Name Security Registered address Wholly owned subsidiaries 14245563 Canada Inc. 14934792 Canada Inc. 1506369 Alberta ULC Action Potential Venture Capital Limited Adechsa GmbH (ii) Affinivax, Inc. Allen & Hanburys Limited (ii) Allen & Hanburys Pharmaceutical Nigeria Limited Allen Pharmazeutika Gesellschaft m.b.H. Beecham Group p.l.c Beecham Pharmaceuticals (Pte) Limited Beecham Portuguesa- Produtos Farmaceuticos e Quimicos, LDA Beecham S.A. Bellus Health Corp. Bellus Health Inc Biovesta Ilaçlari Ltd. Sti. (ii) Cascan GmbH & Co. KG Cellzome GmbH Clarges Pharmaceutical Trustees Limited (ii) Colleen Corporation Corixa Corporation Dealcyber Limited Desarrollo Energia Solar Alternativa S.L. Ordinary Ordinary Common Common Ordinary Ordinary Duncan Pharmaceuticals Philippines Inc. Common Etex Farmaceutica Ltda Social Capital Glaxo Group Limited Glaxo Kabushiki Kaisha (ii) Glaxo New Zealand Pension Plan Trustee Limited Glaxo Operations UK Limited Glaxo Properties BV Glaxo Saudi Arabia Limited Glaxo Verwaltungs GmbH Glaxo Wellcome Farmaceutica, Limitada Glaxo Wellcome Manufacturing Pte Ltd Glaxo Wellcome Production Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Common Common Common Ordinary Ordinary Common Ordinary Ordinary Ordinary £0.05 Ordinary B; £0.20 Ordinary A Ordinary Quota Ordinary Common Common Nominative 275 Armand-Frappier Boulevard, Laval ON H7V 4A7, Canada 100 Milverton Drive, Suite 800, Mississauga ON L5R 4H1, Canada 3500 855-2nd Street SW, Calgary AB T2P 4J8, Canada GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom c/o PRV Provides Treuhandgesellschaft AG, Dorfstrasse 38, 6341, Baar,  Switzerland Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 49, Town Planning Way, Ilupeju, Lagos, Nigeria Wienerbergstraße 7, Wien, 1100, Austria, Austria 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 38 Quality Road, Jurong Industrial Estate, Jurong, 618809, Singapore Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal Avenue Fleming 20, 1300 Wavre, Belgium The Corporation Trust Company, Corporation Trust Center, 1209 Orange  Street, Wilmington DE 19801, United States 275 Boulevard Armand Frappier, Laval QC H7V 4A7, Canada Büyükdere Caddesi No. 173, 1.Levent Plaza B Blok, 1.Levent, Istanbul, 34394,  Turkey Partnership Capital Prinzregentenplatz 9, 81675, Munich, Bavaria, Germany Meyerhofstrasse 1, 69117, Heidelberg, Germany 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Cantos, 28760,  Madrid, Spain 23rd Floor, The Finance Centre, 26th Street Corner 9th Avenue, Bonifacio  Global City, Taguig City, 1634, Philippines Av. Andrés Bello 2457, Costanera Center, Torre 2, Piso 20, Providencia,  Santiago, 7510689, Chile GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom 1-8-1 Akasaka Minato-ku, Tokyo, Japan Level 2 E.2, Generator at GridAKL, 12 Madden Street, Wynyard Quarter,  Auckland, 1010, New Zealand 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands PO Box 22617, Area No 56 to 73, Warehouse City, First Stage Al Khomrah,  Jeddah 21416, Saudi Arabia Prinzregentenplatz 9, 81675, Munich, Bavaria, Germany Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal 1 Pioneer Sector 1, Jurong Industrial Estate, Jurong, 628413, Singapore 23 rue François Jacob, 92500, Rueil-Malmaison, France 306 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Registered address Wholly owned subsidiaries continued Glaxo Wellcome Vidhyasom Limited (in liquidation) (ii) Ordinary Glaxo Wellcome, S.A. Glaxo, S.A. Glaxochem Pte Ltd (iii) Ordinary Ordinary Ordinary GlaxoSmithKline - Produtos Farmaceuticos, Limitada Ordinary Quota GlaxoSmithKline (Cambodia) Co., Ltd. Ordinary GlaxoSmithKline (China) Investment Co Ltd Ordinary GlaxoSmithKline (China) R&D Company Limited Equity GlaxoSmithKline (GSK) S.R.L. GlaxoSmithKline (Ireland) Limited GlaxoSmithKline (Israel) Ltd GlaxoSmithKline (Private) Limited (ii) GlaxoSmithKline (Thailand) Limited GlaxoSmithKline AB GlaxoSmithKline AG GlaxoSmithKline Angola Unipessoal Limitada GlaxoSmithKline Argentina S.A. GlaxoSmithKline AS GlaxoSmithKline Australia Pty Ltd GlaxoSmithKline B.V. GlaxoSmithKline Beteiligungs GmbH GlaxoSmithKline Biologicals Kft. GlaxoSmithKline Biologicals S.A.S. GlaxoSmithKline Biologicals SA GlaxoSmithKline Brasil Limitada GlaxoSmithKline Capital Inc. Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Quota Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary: Preference Quotas Common GlaxoSmithKline (China) R&D Company Limited Equity GlaxoSmithKline (GSK) S.R.L. GlaxoSmithKline (Ireland) Limited GlaxoSmithKline (Israel) Ltd GlaxoSmithKline (Private) Limited (ii) GlaxoSmithKline (Thailand) Limited GlaxoSmithKline AB GlaxoSmithKline AG GlaxoSmithKline Angola Unipessoal Limitada GlaxoSmithKline Argentina S.A. GlaxoSmithKline AS GlaxoSmithKline Australia Pty Ltd GlaxoSmithKline B.V. GlaxoSmithKline Beteiligungs GmbH GlaxoSmithKline Biologicals Kft. GlaxoSmithKline Biologicals S.A.S. GlaxoSmithKline Biologicals SA Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Quota Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary: Preference 12th Floor Wave Place, 55 Wireless Road, Lumpini, Pathumwan, Bangkok, 10 330, Thailand Poligono Industrial Allendeduero, Avenida de Extremadura, 3, Aranda de  Duero, 09400, Burgos, Spain Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Cantos, 28760,  Madrid, Spain 23 Rochester Park, 139234, Singapore Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal 5th Floor DKSH Building, No.797 Preah Monivong Boulevard (Co, Sangkat  Phsar Deum Thakov, Khan Chamkarmon, Phnom Penh, Cambodia Room 901, 902, 903, 905, 908, 909 and 910, Unit 901, Floor 9, No. 56 Mid 4th  East Ring Road, Chaoyang District, Beijing, China F1-3, No.18 Building, 999 Huanke Road, Pilot Free Trade Zone, Shanghai, 201 210, China Str. Dr. Nicolae D. Staicovici nr. 2, Opera Center II, etaj 4, sector 5, București, Romania, 050556 12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland 25 Basel Street, PO Box 10283, Petach-Tikva, 49002, Israel Unit 3, 20 Anthony Road, Msasa, Harare, Zimbabwe 12th Floor Wave Place, 55 Wireless Road, Lumpini, Pathumwan, Bangkok, 10 330, Thailand Hemvarnsg. 9, 171 54, Solna, Sweden Talstrasse 3 , 3053 Muenchenbuchsee, Switzerland Luanda, Bairro Petrangol, Estrada de Cacuaco n ° 288, Angola Tucumán 1, piso 4, Buenos Aires, C1049AAA, Argentina Drammensveien 288, Oslo, NO-0283, Norway Level 4 , 436 Johnston Street , Abbotsford, Victoria, 3067, Australia Van Asch van, Wijckstraat 55h, 3811 LP Amersfoort, The Netherlands,  Netherlands Prinzregentenplatz 9, 81675, Munchen, Germany 2100 Gödöllõ, Homoki Nagy István utca 1, Hungary 637 Rue des Aulnois, Saint-Amand Les Eaux, 59230, France Rue de l'Institut 89 B-1330 Rixensart, Belgium Estrada dos Banderiantes, 8464, Rio de Janeiro, 22783-110, Brazil Wilmington Trust SP Services, Inc., 1100 N. Market Street, 4th Floor,  Wilmington DE 19890, United States F1-3, No.18 Building, 999 Huanke Road, Pilot Free Trade Zone, Shanghai, 201 210, China Str. Dr. Nicolae D. Staicovici nr. 2, Opera Center II, etaj 4, sector 5, București, Romania, 050556 12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland 25 Basel Street, PO Box 10283, Petach-Tikva, 49002, Israel Unit 3, 20 Anthony Road, Msasa, Harare, Zimbabwe 12th Floor Wave Place, 55 Wireless Road, Lumpini, Pathumwan, Bangkok, 10 330, Thailand Hemvarnsg. 9, 171 54, Solna, Sweden Talstrasse 3, 3053 Muenchenbuchsee, Switzerland Luanda, Bairro Petrangol, Estrada de Cacuaco n ° 288, Angola Tucumán 1, piso 4, Buenos Aires, C1049AAA, Argentina Drammensveien 288, Oslo, NO-0283, Norway Level 4 , 436 Johnston Street , Abbotsford, Victoria, 3067, Australia Van Asch van, Wijckstraat 55h, 3811 LP Amersfoort, The Netherlands,  Netherlands Prinzregentenplatz 9, 81675, Munchen, Germany 2100 Gödöllõ, Homoki Nagy István utca 1, Hungary 637 Rue des Aulnois, Saint-Amand Les Eaux, 59230, France Rue de l'Institut 89 B-1330 Rixensart, Belgium 307 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Registered address Wholly owned subsidiaries continued GlaxoSmithKline Brasil Limitada GlaxoSmithKline Capital Inc. GlaxoSmithKline Capital plc GlaxoSmithKline Caribbean Limited Quotas Common Ordinary Ordinary GlaxoSmithKline Chile Farmaceutica Limitada Social Capital Estrada dos Banderiantes, 8464, Rio de Janeiro, 22783-110, Brazil Wilmington Trust SP Services, Inc., 1100 N. Market Street, 4th Floor,  Wilmington DE 19890, United States 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Av. Andrés Bello 2457, Torre 2, piso 20, Providencia, Santiago, Región  Metropolitana, Chile GlaxoSmithKline Colombia S.A. GlaxoSmithKline Consumer Holding B.V. (ii) Ordinary Ordinary Avenida El Dorado, #69B-45/Piso 9, Bogota, Colombia Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands GlaxoSmithKline doo Beograd-Novi Beograd (in liquidation) Ordinary Milutin Milankovic, 1J, Novi Beograd, Belgrade, 11070, Serbia GlaxoSmithKline Ecuador S.A. GlaxoSmithKline El Salvador S.A. de C.V. GlaxoSmithKline EOOD GlaxoSmithKline Export Limited GlaxoSmithKline Export Panama S.A. GlaxoSmithKline Far East B.V. GlaxoSmithKline Finance plc Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Av 10 De Agosto N36-239, y Naciones Unidas, Edificio Electroectuatoriana, 2 do piso, Quito, Ecuador Municipio de San Salvador, Departamento de San Salvador, El Salvador 16 Nedelcho Bonchev str., Sofia, Sofiya, 1592, Bulgaria 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Panama City, Republic of Panama, Panama Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands 980 Great West Road, Brentford, Middlesex, TW8 9GS, England GlaxoSmithKline GmbH & Co. KG Partnership Capital Prinzregentenplatz 9, 81675, Munchen, Germany GlaxoSmithKline Guatemala S.A. GlaxoSmithKline Holding AS GlaxoSmithKline Holdings (Americas) Inc. GlaxoSmithKline Holdings (One) Limited (i) GlaxoSmithKline Holdings Limited (i) GlaxoSmithKline Holdings Pty Ltd GlaxoSmithKline Honduras S.A. GlaxoSmithKline IHC Limited Ordinary Ordinary Common Ordinary Ordinary Ordinary Ordinary Ordinary GlaxoSmithKline Ilaclari Sanayi ve Ticaret A.S. Nominative GlaxoSmithKline Inc. GlaxoSmithKline Insurance Ltd. Class A Common; Class C Preference Ordinary GlaxoSmithKline Intellectual Property (No.2) Limited Ordinary GlaxoSmithKline Intellectual Property Development Limited Ordinary GlaxoSmithKline Intellectual Property Holdings Limited GlaxoSmithKline Intellectual Property Limited A Ordinary; B Ordinary Deferred; Ordinary GlaxoSmithKline Intellectual Property Management Limited Ordinary GlaxoSmithKline Investigación y Desarrollo, S.L. Ordinary GlaxoSmithKline Investments Pty Ltd GlaxoSmithKline K.K. GlaxoSmithKline Korea Limited GlaxoSmithKline Latin America, S.A. GlaxoSmithKline Limited GlaxoSmithKline Limited (ii) GlaxoSmithKline LLC GlaxoSmithKline Manufacturing SpA GlaxoSmithKline Maroc S.A. Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary LLC Interests Ordinary Ordinary 3ra. Av. 13-78 Zona 10, Torre Citibank, Nivel 8, Guatemala City, Guatemala Drammensveien 288, Oslo, NO-0283, Norway Wilmington Trust SP Services Inc., 1100 North Market Street, 4th Floor,  Wilmington, Delaware, 19890 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Level 4 , 436 Johnston Street , Abbotsford, Victoria, 3067, Australia Tegucigalpa, MDC, Honduras 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Büyükdere Caddesi No. 173, 1.Levent Plaza B Blok, 1.Levent, Istanbul, 34394,  Turkey 100 Milverton Drive, Suite 800, Mississauga ON L5R 4H1, Canada c/o Trinity Corporate Services Ltd., Trinity Hall, 43 Cedar Avenue, Hamilton,  Hamilton, HM12, Bermuda GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom Severo Ochoa 2 Parque Tecnológico de Madrid, Tres Cantos, 28760, Madrid Spain Level 4, 436 Johnston Street, Abbotsford, Victoria, 3067, Australia 1-8-1 Akasaka Minato-ku, Tokyo, Japan 9F LS Yongsan Tower, 92 Hangang-daero, Yongsangu, Seoul, 04386,  Korea, Republic of Panama City, Republic of Panama, Panama 23/F., Tower 6, The Gateway, 9 Canton Road, Tsimshatsui, Kowloon,  Hong Kong 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Viale dell’Agricoltura 7, 37135, Verona, Italy 42-44 Angle Bd, Rachidi et Abou Hamed El Glaza, Casablanca, Morocco GlaxoSmithKline Medical and Healthcare Products Kft Ordinary 1062 Budapest, Andrassy ut 113, Hungary GlaxoSmithKline Mercury Limited (i) Ordinary 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 308 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Registered address Wholly owned subsidiaries continued GlaxoSmithKline Mexico S.A. de C.V. GlaxoSmithKline NZ Limited GlaxoSmithKline Oy GlaxoSmithKline Peru S.A. GlaxoSmithKline Pharma A/S GlaxoSmithKline Pharma GmbH GlaxoSmithKline Pharmaceutical Kenya Limited GlaxoSmithKline Pharmaceutical Nigeria Limited GlaxoSmithKline Pharmaceutical Sdn Bhd GlaxoSmithKline Pharmaceuticals (Pvt) Ltd GlaxoSmithKline Pharmaceuticals Costa Rica S.A GlaxoSmithKline Pharmaceuticals SA Ordinary A; Ordinary B Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Av. Real Mayorazgo 130 Piso 20, Colonia Xoco, Alcaldia Benito Juárez,  Ciudad de Mexico, 03330, Mexico Level 2 E.2, Generator @GridAKL, 12 Madden Street, Wynyard Quarter,  Auckland, 1010, New Zealand Porkkalankatu 20 A, Helsinki, 00180, Finland Av. Víctor Andrés Belaúnde N°147, Vía Principal N°133, Piso 7, Distrito de San Isidro, Lima, Peru Vallensbæk Company House III , Delta Park 37, DK-2665, Valle, Denmark Wienerbergstraße 7, Wien, 1100, Austria, Austria P.O Box 78392-00507, Likoni Road, Nairobi, Kenya 1 Industrial Avenue, Ilupeju, Ikeja, Lagos, PM B 21218, Nigeria HZ.01, Horizon Penthouse, 1 Powerhouse, 1, Persiaran Bandar Utama, Bandar  Utama, 47800 Petaling Jaya, Selangor, Malaysia 121 Galle Road, Kaldemulla, Moratuwa, Sri Lanka Autopista Florencia del Castillo, kilómetro siete, Oficentro TerraCampus,  edificio uno, cuarto piso, San Diego, Cartago, 30302, Costa Rica Avenue Fleming 20, 1300 Wavre, Belgium GlaxoSmithKline Pharmaceuticals Ukraine LLC Chartered Capital Pavla Tychyny avenue, 1-V, Kiev, 02152, Ukraine GlaxoSmithKline Philippines Inc GlaxoSmithKline Pte Ltd GlaxoSmithKline Puerto Rico, Inc. Ordinary Ordinary Common GlaxoSmithKline Republica Dominicana S.A. Ordinary GlaxoSmithKline Research & Development Limited GlaxoSmithKline S.A. GlaxoSmithKline S.p.A. GlaxoSmithKline s.r.o. Ordinary Ordinary Ordinary Ordinary 23rd Floor, The Finance Centre, 26th Street Corner 9th Avenue, Bonifacio  Global City, Taguig City, 1634, Philippines 23 Rochester Park, 139234, Singapore CORPORATION SERVICE COMPANY PUERTO RICO INC.,  c/o RVM Professional Services, LLC, A4 Reparto Mendoza, Humacao,  00791, Puerto Rico Blue Mall Tower, Floor 23 Ave., Winston Churchill 95, Santo Domingo,  Dominican Republic 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Cantos, 28760,  Madrid, Spain Viale dell’Agricoltura 7, 37135, Verona, Italy Hvezdova 1734/2c, Prague, 4 140 00, Czech Republic GlaxoSmithKline Services GmbH & Co. KG Partnership Capital Prinzregentenplatz 9, 81675, Munchen, Germany GlaxoSmithKline Services Unlimited (i) GlaxoSmithKline Single Member A.E.B.E. GlaxoSmithKline SL LLC GlaxoSmithKline SL LP (ii)(viii) GlaxoSmithKline South Africa (Pty) Limited GlaxoSmithKline Trading Services Limited (iii) GlaxoSmithKline Tunisia S.A.R.L. GlaxoSmithKline UK Limited GlaxoSmithKline Uruguay S.A. GlaxoSmithKline US Trading Limited GlaxoSmithKline Venezuela C.A. Ordinary Ordinary LLC Interests Partnership Ordinary Ordinary Ordinary Ordinary 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 266 Kifissias Avenue, Halandri, Athens, 152 32, Greece Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Flushing Meadows Building, The Campus, 57 Sloane Street, Bryanston 2021,  South Africa 12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland Immeuble REGUS, Lot B17, Centre Urbain Nord, Tunis, Tunisia 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Registered Provisory Stock Victor Soliño 349, Montevideo, Montevideo, 11300, Uruguay Ordinary Ordinary GlaxoSmithKline Vietnam Limited Liability Company (ii) Equity Capital GlycoVaxyn AG (In liquidation) Groupe GlaxoSmithKline GSK Biopharma Argentina S.A. Common; Preferred A; Preferred B; Preferred C Ordinary Nominative Non  Endorseable Ordinary GSK (No.1) Scottish Limited Partnership (viii) Partnership GSK (No.2) Scottish Limited Partnership (viii) Partnership GSK (No.3) Scottish Limited Partnership (viii) Partnership 980 Great West Road, Brentford, Middlesex, TW8 9GS, England calle Altagracia, edificio P&G, piso Mezzanina, torre Torre Sur, Urbanizacion  Sorokaima, La Trinidad, Caracas, 1080, Venezuela, Bolivarian Republic of The Metropolitan, 235 Dong Khoi Street, District 1, 7th Floor Unit 701, Ho Chi  Minh City, Vietnam Grabenstrasse 3, 8952 Schlieren, Switzerland 23 rue François Jacob, 92500, Rueil-Malmaison, France Tucumán 1, piso 4, Buenos Aires, C1049AAA, Argentina 50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ,  United Kingdom 50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ,  United Kingdom 50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ,  United Kingdom 309 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Registered address Wholly owned subsidiaries continued GSK Business Service Centre Sdn Bhd GSK Capital B.V. (iii)(v) GSK Capital K.K. GSK Commercial Sp. z o.o. GSK d.o.o., Ljubljana GSK Enterprise Management Co, Ltd GSK Equity Investments, Limited GSK Finance (No.3) PLC GSK Finance (No 2) Limited GSK India Global Services Private Limited Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Units Ordinary Ordinary Equity Level 6, Quill 9, 112 Jalan Prof. Khoo Kay Kim, Petaling Jaya, 46300 Selangor,  Malaysia 980 Great West Road, Brentford, Middlesex, TW8 9GS 1-8-1 Akasaka Minato-ku, Tokyo, Japan ul. Rzymowskiego 53, 02-697, Warsaw, Poland Ameriška ulica 8, Ljubljana, 1000, Slovenia Floor 4, 18 Lane 999 Huanke Road, No. 1358 Zhongke Road, Shanghai, China Corporation Service Company, 2595 Interstate Drive, Suite 103, Harrisburg  PA 17110, United States 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Level 1, 2 & 3 Luxor North Tower, Bagmane Capital Business Park Outer Ring  Road, Bangalore, Karnataka, 560037, India GSK International Holding and Finance BV Ordinary Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands GSK Kazakhstan LLP Participation Interest GSK Life Sciences FZE GSK Pharma India Private Limited Ordinary Equity GSK Pharma Vietnam Company Limited Chartered Capital GSK Pharmaceutical Trading S.A. (ii) Ordinary Nursultan Nazarbayev Ave 273, Business center USKO, 3rd fl., Almaty,  050059, Kazakhstan LB06015, Jebel Ali Freezone, Dubai, United Arab Emirates 1, Battery House, Bhulabhai Desai Raod, Mumbai, Maharashtra, 400026,  India Unit 702/703 7th Floor, The Metropolitan Tower, 235 Dong Khoi Street,  Ben Nghe Ward, District 1, Ho Chi Minh, Vietnam Bucharest, 1-5 Costache Negri Street, Opera Center One, 5th floor,  discussions room 01, District 5, Romania GSK PSC Poland sp. z o.o. Equal and indivisible shares  ul. Grunwaldzka 189, Poznań, 60-322, Pol GSK Services Sp z o.o. GSK Vaccines BV GSK Vaccines GmbH GSK Vaccines Institute for Global Health S.r.l. GSK Vaccines S.r.l. GSK Vaccines Vertriebs GmbH Human Genome Sciences, Inc. ID Biomedical Corporation of Quebec Instituto Luso Farmaco, Limitada (ii) InterPharma Dienstleistungen GmbH J&J Technologies, LC (ii) JSC GlaxoSmithKline Trading Laboratoire GlaxoSmithKline Ordinary Ordinary Ordinary Quota Quota Ordinary Common Common Quota Quota LLC Interests Ordinary Ordinary Ul. Grunwaldzka 189, 60-322, Poznan, Poland Hullenbergweg 85, 1101 CL, Amsterdam, Netherlands Emil-von-Behring-Str.76, 35041 Marburg, Germany Via Fiorentina 1, 53100, Siena, Italy Via Fiorentina 1, 53100, Siena, Italy Rudolf-Diesel-Ring 27, 83607, Holzkirchen, Germany Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States 2323, boul. Du Parc Technologique, Québec Québec G1P 4R8, Canada Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal Wienerbergstraße 7, Wien, 1100, Austria, Austria Corporation Service Company, 100 Shockoe Slip, 2nd Floor, Richmond VA  23219, United States Leningradskiy Prospect 37A, Building 4, Floor 3, Premises XV, Room 1, 125167,  Moscow, Russian Federation 23 rue François Jacob, 92500, Rueil-Malmaison, France Laboratoire Pharmaceutique Algérien LPA Production SPA Ordinary Zone Industrielle Est, Boudouaou, Boumerdes, Algeria Laboratoire Pharmaceutique Algérien SPA Laboratoires Paucourt (ii) Laboratoires Saint-Germain (ii) Laboratorios Dermatologicos Darier, S.A de C.V. Ordinary Ordinary Ordinary Ordinary A; Ordinary B Laboratorios Farmaceuticos Stiefel (Portugal) LTDA (ii) Ordinary Laboratorios Stiefel de Venezuela SA Ordinary Laboratorios Stiefel Ltda. Ordinary Laboratorios Wellcome De Portugal Limitada (ii) Quota Maxinutrition Limited (in liquidation) PT Glaxo Wellcome Indonesia Setfirst Limited Ordinary Class A; Class B Ordinary Zone Industrielle Est, Boudouaou, Boumerdes, Algeria 23 rue François Jacob, 92500, Rueil-Malmaison, France 23 rue François Jacob, 92500, Rueil-Malmaison, France Av. Real Mayorazgo 130 Piso 20, Colonia Xoco, Alcaldia Benito Juárez,  Ciudad de Mexico, 03330, Mexico Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal Calle Altagracia, edificio P&G, nivel Mezzanina,, piso Mezzanina, local Torre  Sur, Urbanizacion Sorokaima, La Trinidad, Caracas, 1080, Venezuela,  Bolivarian Republic of Rua Professor Joao Cavalheiro Salem, no.1077, Bairro de Bonsucesso,  Municipality of Guarulhos, Sao Paulo, CEP 07243-580, Brazil Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal C/O BDO LLP, 5 Temple Square, Temple Street, Liverpool, L2 5RH JL. Pulobuaran Raya Kav.III/ DD 2,3,4 KWS. Industri, Pulogadung, Jatinegara, Cakung, Jakarta Timur,  Indonesia 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 310 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Registered address Wholly owned subsidiaries continued Sierra Oncology Australia Pty Ltd Sierra Oncology Canada ULC Sitari Pharma, Inc. Smith Kline & French Portuguesa- Produtos Farmaceuticos, LDA (ii) SmithKline Beecham (Bangladesh) Private Limited (ii) SmithKline Beecham (Cork) Limited SmithKline Beecham Egypt L.L.C. SmithKline Beecham Farma, S.A. SmithKline Beecham Legacy H Limited SmithKline Beecham Limited SmithKline Beecham Pension Plan Trustee Limited Ordinary Common Common Ordinary Ordinary Ordinary Quota Ordinary Ordinary Ordinary Ordinary c/o Maddocks Lawyers, Angel Place, Level 27, 123 Pitt Street Sydney 2000,  Australia Suite 1800 - 510 West Georgia Street, Vancouver BC V6B 0M3, Canada Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal House-2/A, Road-138,Gulshan-1, Dhaka, 1212, Bangladesh 12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland Amoun Street, El Salam City, Cairo, Egypt Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Cantos, 28760,  Madrid, Spain 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 980 Great West Road, Brentford, Middlesex, TW8 9GS, England SmithKline Beecham Pharma GmbH & Co KG Partnership Capital Prinzregentenplatz 9, 81675, Munchen, Germany SmithKline Beecham Pharma Verwaltungs GmbH Ordinary Prinzregentenplatz 9, 81675, Munchen, Germany SmithKline Beecham Pharmaceuticals (Pty) Limited (ii) Ordinary SmithKline Beecham Pharmaceuticals Co. Common SmithKline Beecham Senior Executive Pension Plan Trustee  Limited (ii) Ordinary Flushing Meadows Building, The Campus, 57 Sloane Street, Bryanston 2021,  South Africa Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Stiefel GmbH & Co. KG Partnership Capital Prinzregentenplatz 9, 81675, Munchen, Germany Stiefel Laboratories Legacy (Ireland) Limited Stiefel Laboratories Pte Limited Stiefel Laboratories, Inc. Stiefel Maroc SARL Stiefel Research (Australia) Holdings Pty Ltd Stiefel Research Australia Pty Ltd Stiefel West Coast LLC Strebor Inc. Tesaro Bio GmbH (in liquidation) Tesaro Bio Netherlands B.V Tesaro Development, Ltd. Tesaro, Inc. The Sydney Ross Co. (ii) UCB Pharma Asia Pacific Sdn Bhd (ii) Wellcome Consumer Healthcare Limited (ii) Wellcome Limited Ordinary Ordinary Common Ordinary Ordinary Ordinary LLC Interests Common Ordinary Ordinary Ordinary Common Ordinary Ordinary Ordinary Ordinary Unit 2 Building 2500, Avenue 2000 Cork Airport Business Park, Cork, Ireland 1 Pioneer Sector, 628413, Singapore Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States 275 Boulevard Zerktouni, Casablanca, Morocco Level 4, 436 Johnston Street, Abbotsford, Victoria, 3067, Australia Level 4, 436 Johnston Street, Abbotsford, Victoria, 3067, Australia Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Poststrasse 6, 6300 Zug, Switzerland Joop Geesinkweg 901, 1114 AB, Amsterdam-Duivendrecht, Netherlands Clarendon House, 2 Church Street, Hamilton HM11, Bermuda Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Corporation Service Company, Princeton South Corporate Center, Suite 160,  100 Charles Ewing Blvd, Ewing NJ 08628, United States 12th Floor, Menara Symphony, No. 5, Jalan Prof. Khoo Kay Kim, Seksyen 13, 4 6200 Petaling Jaya, Malaysia 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Name Security Subsidiaries where the effective interest is less than 100% Effective % Ownership Registered address Amoun Pharmaceutical Industries Co. S.A.E. Monetary Shares 90.71% El Salam City 11491, PO Box 3001, Cairo, Egypt Biddle Sawyer Limited Equity 75.00% 252 Dr Annie Besant Road, Mumbai, 400030, India British Pharma Group Limited (i) Guarantee (50%) 50.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England Galvani Bioelectronics Inc. Common Galvani Bioelectronics Limited A Ordinary; B Ordinary Glaxo Laboratories (Nigeria) Limited (ii) Ordinary 55.00% 55.00% - 99.99% Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom 82 Marine Road, Apapa, Lagos, Nigeria Glaxo-Allenburys (Nigeria) Limited (ii) Ordinary 99.00% 41 Creek Road, Apapa, Lagos, PMB 1401, Nigeria 311 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Effective % Ownership Registered address Subsidiaries where the effective interest is less than 100% continued GlaxoSmithKline (Tianjin) Co. Ltd Ordinary 90.00% No. 65, the Fifth Avenue, Tai Feng Industrial Park, Tianjin Economic and  Technolog, Tianjin, 300457, China GlaxoSmithKline Algérie S.P.A. Ordinary 99.99% Zone Industrielle Est, Boudouaou, Wilaya de Boumerdes, Algeria GlaxoSmithKline Consumer Nigeria plc (vi) Ordinary GlaxoSmithKline Pakistan Limited Ordinary 46.42% 82.59% 1 Industrial Avenue, Ilupeju, Ikeja, Lagos, PM B 21218, Nigeria The Sykes Building, 35 Dockyard Road, West Wharf, Karachi, 74000,  Pakistan GlaxoSmithKline Pharmaceuticals Limited Equity 75.00% 252 Dr Annie Besant Road, Mumbai, 400030, India GlaxoSmithKline S.A.E. Ordinary Laboratorios ViiV Healthcare, S.L. Ordinary Modern Pharma Trading Company L.L.C. Quota PHIVCO-1 LLC PHIVCO-2 LLC LLC Interests LLC Interests 91.20% 78.30% 98.24% 78.30% 78.30% SmithKline Beecham-Biomed O.O.O. Participation Interest 97.00% Boomerang Office Building - Land No. 46, Zone (J) -  1st District, Town Center - 5th Tagammoe, New Cairo City, Egypt Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Cantos, 28760,  Madrid, Spain Amoun Street, PO Box 3001, El Salam City, Cairo, 11491, Egypt Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States Leningradskiy Prospect 37A, Building 4, Floor 2, Premises XIV, Room 42, 1251 67, Moscow, Russian Federation Stiefel Egypt LLC (ii) ViiV Healthcare (South Africa) (Proprietary)  Limited ViiV HealthCare BV ViiV Healthcare Company Quota Ordinary Ordinary Common 99.00% Amoun Street, PO Box 3001, El Salam City, Cairo, 11491, Egypt 78.30% 78.30% 78.30% Flushing Meadows Building, The Campus, 57 Sloane Street, Bryanston 2021,  South Africa Van Asch van, Wijckstraat 55h, 3811 LP Amersfoort, The Netherlands,  Netherlands Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808,  United States ViiV Healthcare Finance 2 Limited Ordinary 78.30% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England ViiV Healthcare Finance Limited Ordinary; Redeemable Preference 78.30% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England ViiV Healthcare GmbH ViiV Healthcare GmbH ViiV Healthcare K.K. ViiV Healthcare Limited Ordinary Ordinary Ordinary A Ordinary; B Ordinary; C Ordinary; D1 Preference; D2 Ordinary; Deferred; E 5% Cumulative Preference ViiV Healthcare Pty Ltd ViiV Healthcare Puerto Rico, LLC Ordinary LLC Interests ViiV Healthcare S.r.l. ViiV Healthcare SAS ViiV Healthcare sprl Quota Ordinary Ordinary ViiV Healthcare Trading LLC (ii) Participation Interest ViiV Healthcare Trading Services UK Limited Ordinary ViiV Healthcare UK (No.3) Limited Ordinary ViiV Healthcare UK (No.4) Limited Ordinary ViiV Healthcare UK (No.5) Limited Ordinary ViiV Healthcare UK (No.6) Limited Ordinary ViiV Healthcare UK (No.7) Limited Ordinary ViiV Healthcare UK Limited ViiV Healthcare ULC Ordinary Common 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% 78.30% Prinzregentenplatz 9, 81675, Munchen, Germany Talstrasse 3 , 3053 Muenchenbuchsee, Switzerland 1-8-1 Akasaka Minato-ku, Tokyo, Japan GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom Level 4, 436 Johnston Street, Abbotsford, Victoria, 3067, Australia CORPORATION SERVICE COMPANY PUERTO RICO INC.,  c/o RVM Professional Services, LLC, A4 Reparto Mendoza, Humacao,  Puerto Rico, 00791 Viale dell’Agricoltura 7, 37135, Verona, Italy 23 rue François Jacob, 92500, Rueil-Malmaison, France Avenue Fleming 20, 1300 Wavre, Belgium Leningradskiy Prospect 37A, Building 4, Floor 2, Premises XIV, Room 28, 1251 67, Moscow, Russian Federation 980 Great West Road, Brentford, Middlesex, TW8 9GS, England GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY,  United Kingdom 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 3500 855-2nd Street SW, Calgary AB T2P 4J8, Canada 312 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued Name Security Effective % Ownership Registered address Subsidiaries where the effective interest is less than 100% continued ViiVHIV Healthcare Unipessoal Lda Quota Winster Pharmaceuticals Limited Ordinary 78.30% 46.42% Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131,  Alges, Portugal 2A Association Avenue, Ilupeju Industrial Estate, Lagos, PO Box 3199,  Nigeria Name Associates Security Effective % Ownership Registered address GlaxoSmithKline Landholding Company, Inc Common 39.93% 23rd Floor, The Finance Centre, 26th Street Corner 9th Avenue, Bonifacio Global City, Taguig City, 1634, Philippines Index Ventures Life VI (Jersey) LP Kurma Biofund II FCPR Longwood Fund I, LP Medicxi Ventures I LP Joint Ventures Partnership Interest (24.94%) Partnership Interest (32.06%) Partnership Interest (35%) Partnership Interest (26.10%) 24.94% 44 Esplanade, St Helier, Jersey, JE4 9WG, Channel Islands 32.06% 24 rue Royale, 5th Floor, 75008, Paris, France 35.00% The Prudential Tower, Suite 1555, 800 Boylston Street, Boston, MA 02199 26.10% 44 Esplanade, St Helier, Jersey, JE4 9WG, Channel Islands Chiron Panacea Vaccines Private Limited (in Liquidation) Equity Shares 50.00% 708/718, 7th Floor, A Wing, Sagar Tech Plaza, Saki Naka, Andheri East, Mumbai, Maharashtra, 400072, India Other significant holdings Axon Therapies, Inc Alpheus Medical, Inc. Global Farm S.A. Longwood Fund II, LP Sanderling Ventures VII, L.P. A63 SR One Capital Fund I-B, LP SR One Capital Opportunities Fund I, LP 20.03% 2326 Walsh Avenue Santa Clara, CA 95051, United States 21.04% 3510 Hopkins Place, North Oakdale,  Minnesota 55128, USA Common (2.63%); Series A Preference (18.40%) Series A Preference (13.77%) Series A-1 Preference (7.27%) A Shares (0%) B Shares (0%) C Shares (100%) 20.00% 100% of C Shares Mendoza 1259, Ciudad Autónoma de Buenos Aires, Argentina Partnership Interest (20.00%) Partnership Interest (25.31%) Partnership Interest (44%) Partnership Interest (24.46%) 20.00% The Prudential Tower, Suite 1555, 800 Boylston Street, Boston, MA 02199 25.31% 400 S. El Camino Real, Suite 1200, San Mateo, CA 94402 44.00% 24.46% Corporation service company, 251 Little Falls Drive, City of Wilmington, County of New Castle, Delaware 19808 Corporation service company, 251 Little Falls Drive, City of Wilmington, County of New Castle, Delaware 19808 313 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Group companies continued The following UK registered subsidiaries will take advantage of the audit exemption set out within Section 479A of the Companies Act 2006 for the period ended 31 December 2023. Unless otherwise stated, the undertakings listed below are owned, either directly or indirectly, by GSK plc. Name Security Effective % Ownership Registered address Company Number UK registered subsidiaries exempted from audit Burroughs Wellcome International Limited Domantis Limited Edinburgh Pharmaceutical Industries Limited (ii) Eskaylab Limited Glaxo Wellcome UK Limited Glaxochem (UK) Unlimited Ordinary Ordinary Ordinary; Preference; Ordinary Ordinary Ordinary; Ordinary B; Ordinary C 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 543757 100.00% GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom 3907643 100.00% Shewalton Road, Irvine, Ayrshire, KA11 5AP, United Kingdom SC005534 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 99025 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 480080 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 4299472 GlaxoSmithKline Intellectual Property (No.3) Limited Ordinary 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 11480952 GlaxoSmithKline Intellectual Property (No.4) Limited Ordinary 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 11721880 GlaxoSmithKline Intellectual Property (No.5) Limited Ordinary 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 11959399 GlaxoSmithKline International Limited GSK GP 1 Limited (iv) GSK GP 2 Limited (iv) GSK LP Limited (i)(iv) Montrose Fine Chemical Company Ltd. PHIVCO UK II Limited PHIVCO UK Limited Smith Kline & French Laboratories Limited SmithKline Beecham (Export) Limited SmithKline Beecham (H) Limited SmithKline Beecham (Investments) Limited SmithKline Beecham Marketing and Technical Services Limited SmithKline Beecham Nominees Limited SmithKline Beecham Overseas Limited SmithKline Beecham Pension Plan Trustee Limited Stiefel Laboratories (U.K.) Ltd Tesaro UK Limited The Wellcome Foundation Limited ViiV Healthcare Overseas Limited Ordinary A Shares; B Shares Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Non-cumulative Non-redeemable; Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary Ordinary 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 2298366 100.00% 100.00% 50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ, United Kingdom SC721605 50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ, United Kingdom SC721606 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 13879411 100.00% Shewalton Road, Irvine, Ayrshire, KA11 5AP, United Kingdom SC190635 78.30% 78.30% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 6944229 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 6944223 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 52207 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 2860752 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 3296131 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 302065 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 494385 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 503868 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 2552828 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 3425311 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 831160 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 7890847 100.00% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 194814 78.30% 980 Great West Road, Brentford, Middlesex, TW8 9GS, England 7027385 In accordance with Section 479C of the Companies Act 2006, the company will guarantee debts and liabilities of the above UK subsidiary undertakings. As at 31 December 2023 the total sum of these debts and liabilities is £317 million (2022 – £1266 million) Key (i) Directly owned by GSK plc. (ii) Dormant entity. (iii) Tax resident in the UK. (iv) Exempt under Regulation 7 of the Partnership (Accounts) Regulations 2008 from the requirement to deliver to the registrar financial statements of the qualifying partnership(s) of which the entity is a member in accordance with the Companies Act. Incorporated in the Netherlands (v) (vi) Consolidated as a subsidiary in accordance with Section 1162 (4)(a) of the Companies Act 2006 on the grounds of dominant influence. (vii) Principal business address in Puerto Rico. (viii) Exempt from the provisions of Regulations 4-6 of the Partnership (Accounts) Regulation 2008, in accordance with the exemptions noted in Regulation 7 of that Regulation. 314 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Glossary of terms Terms used in the Annual Report US equivalent or brief description Accelerated capital allowances Tax allowance in excess of depreciation arising from the purchase of fixed assets that delay the charging and payment of tax. The equivalent of tax depreciation. American Depositary Receipt (ADR) Receipt evidencing title to an ADS. Each GSK ADR represents two Ordinary Shares American Depositary Shares (ADS) Listed on the New York Stock Exchange; represents two Ordinary Shares Basic earnings per share Called up share capital CER growth The company Currency swap Defined benefit plan Defined contribution plan Basic income per share Ordinary Shares, issued and fully paid. Growth at constant exchange rates. GSK plc An exchange of two currencies, coupled with a subsequent re-exchange of those currencies, at agreed exchange rates and dates Pension plan with specific employee benefits, often called ‘final salary scheme’. Pension plan with specific contributions and a level of pension dependent upon the growth of the pension fund. Derivative financial instrument A financial instrument that derives its value from the price or rate of some underlying item Diluted earnings per share Diluted income per share. Employee Share Ownership Plan Trusts Trusts established by the Group to satisfy share-based employee incentive plans Equity Shareholders’ funds Finance lease Freehold The Group GSK Hedging Intangible fixed assets Ordinary share Profit Profit attributable to shareholders Share capital Share option Shareholders’ equity. Capital lease. Ownership with absolute rights in perpetuity GSK plc and its subsidiary undertakings. GSK plc and its subsidiary undertakings. The reduction of risk, normally in relation to foreign currency or interest rate movements, by making off-setting commitments. Assets without physical substance, such as computer software, brands, licences, patents, know-how and marketing rights purchased from outside parties. A fully paid up ordinary share in the capital of the company. Income Net income Ordinary Shares, capital stock or common stock issued and fully paid. Stock option. Share premium account Additional paid-up capital or paid-in surplus (not distributable). Shares in issue Subsidiary Treasury share Turnover UK Corporate Governance Code The number of shares outstanding. An entity in which GSK exercises control. Treasury stock. Revenue. As required by the UK Listing Authority, the company has disclosed in the Annual Report how it has applied the best practice corporate governance provisions of the Financial Reporting Council’s UK Corporate Governance Code. 315 Strategic report | Governance and remuneration | Financial statements | Investor information GSK Annual Report 2023 Other statutory disclosures continued Index Access Accounting principles and policies Acquisitions and disposals Adjustments reconciling Total profit after tax to operating cash flows Annual General Meeting 2023 Approach to tax Assets held for sale Associates and joint ventures Audit & Risk Committee Report Business model Cash and cash equivalents Cash generation and conversion CEO’s statement Chair’s statement Chair’s Governance statement Climate-related financial disclosure Commitments Continuous engagement and key decisions Consolidated balance sheet Consolidated cash flow statement Consolidated income statement Consolidated statement of changes in equity Consolidated statement of comprehensive income Contingent consideration liabilities Contingent liabilities Corporate governance Corporate Responsibility Committee Report Critical accounting judgements and key sources of estimation uncertainty Critical accounting policies Demerger of Consumer Healthcare business Directors and senior management Directors’ interests in shares Directors’ report Directors’ statement of responsibilities Dividends Donations to political organisations and political expenditure Earnings per share Employee costs Employee share schemes Environment Ethical standards Exchange rates Finance expense Finance income Financial calendar 2024 Financial instruments and related disclosures Financial performance summary Financial position and resources General Medicines Glossary of terms Goodwill Group companies Group financial review GSK Leadership Team GSK plc (parent company) accounts - UK GAAP Independent Auditor’s report Innovation Inventories Investments in associates and joint ventures Investor relations Key performance indicators Legal proceedings 47 185 236 240 298 103 215 202 133 08 215 97 06 04 114 62 231 121 181 183 180 182 180 229 230 107 128 191 105 238 158 156 161 164 206 305 206 199 260 49 53 193 201 201 298 243 81 98 40,88 315 209 306 78 112 267 166 09 214 212 302 02 263 Major restructuring costs Movements in equity Net debt New accounting requirements Nominations & Corporate Governance Committee Report Non-controlling interests Non-controlling interests in ViiV Healthcare Non-Executive Directors’ fees Non-financial and sustainability information statement Notes to the financial statements Operating profit Other intangible assets Other investments Other non-current assets Other non-current liabilities Other operating income/(expense) Other provisions Our culture and people Our external environment Our long-term priorities Pensions and other post-employment benefits Performance Pharmaceutical products, competition and intellectual property Pipeline Post balance sheet events Presentation of the financial statements Principal Group companies Principal risks and uncertainties Property, plant and equipment Reconciliation of net cash flow to movement in net debt Registrar Related party transactions Reliable supply Remuneration Committee Chair's annual statement Remuneration governance Remuneration report Reporting framework Research and development Responsible business Right of use assets Risk management Science Committee report Section 172 statement Share capital and control Share capital and share premium account Share Consolidation Shareholder information Shareholder services and contacts Specialty Medicines Task Force on Climate-related Financial Disclosures Taxation Tax information for shareholders The Board Three-year selected financial data Trade and other payables Trade and other receivables Treasury policies Trust Turnover and segment information US law and regulation Using data responsibly Vaccines Vaccine products, competition and intellectual property Viability statement 200 232 217 193 131 234 84 155 75 184 198 210 213 213 230 197 228 14 10 09 219 02 281 277 266 268 262 284 207 241 301 235 44 139 153 139 82 17 46 208 57 129 123 295 232 232 295 301 37,87 62 203 299 108 275 216 214 104 09 194 303 54 33,86 283 76 316 About GSK GSK plc was incorporated as GlaxoSmithKline plc, an English public limited company on 6 December 1999. We were formed by a merger between Glaxo Wellcome plc and SmithKline Beecham plc. GSK acquired these two English companies on 27 December 2000 as part of the merger arrangements. Effective 15 May 2022 GlaxoSmithKline plc changed its name to GSK plc. On 18 July 2022, GSK plc separated its Consumer Healthcare business from the GSK Group to form Haleon, an independent listed company. Brand names appearing in italics throughout this report are trade marks either owned by and/or licensed to GSK or associated companies. All other trade marks are the property of their respective owners. Printed sustainably in the UK by Pureprint, a CarbonNeutral® company with FSC® chain of custody and an ISO 14001 certified environmental management system recycling over 99% of all dry waste. Printed on Arena ECO 50 EW Smooth, a wood free uncoated paper, ECF with FSC certification and made from 50% recycled fibre. Download PDFs: – Annual Report 2023 – Form 20-F Our shares are listed on the London Stock Exchange and the New York Stock Exchange. – ESG Performance Report 2023 – Full-year and Fourth Quarter 2023 Results gsk.com Cautionary statement regarding forward-looking statements This document and the Group’s other reports published or filed with or furnished to the US Securities and Exchange Commission (SEC), and any other written information released, or oral statements made, to the public in the future by or on behalf of the Group, may contain forward- looking statements. Forward-looking statements give the Group’s current expectations or forecasts of future events. An investor can identify these statements by the fact that they do not relate strictly to historical or current facts. They use words such as ‘anticipate’, ‘estimate’, ‘expect’, ‘intend’, ‘will’, ‘project’, ‘plan’, ‘believe’, ‘target’ and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. In particular, these include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, the outcome of contingencies such as legal proceedings, dividend payments and financial results. Other than in accordance with its legal or regulatory obligations (including under the Market Abuse Regulation, the UK Listing Rules and the Disclosure and Transparency Rules of the Financial Conduct Authority), the Group undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. The reader should, however, consult any additional disclosures that the Group may make in any documents which it publishes and/or files with the SEC. All readers, wherever located, should take note of these disclosures. Accordingly, no assurance can be given that any particular expectation will be met and investors are cautioned not to place undue reliance on the forward- looking statements. Forward-looking statements are subject to assumptions, inherent risks and uncertainties, many of which relate to factors that are beyond the Group’s control or precise estimate. The Group cautions investors that a number of important factors, including those in this document, could cause actual results to differ materially from those expressed or implied in any forward-looking statement. Such factors include, but are not limited to, those discussed under ‘Principal risks and uncertainties’ on pages 284 to 294 of this Annual Report. Any forward- looking statements made by or on behalf of the Group speak only as of the date they are made and are based upon the knowledge and information available to the Directors on the date of this report. A number of non-IFRS measures are used to report the performance of our business. These measures are defined on pages 83 to 84 and a reconciliation of Adjusted results to Total results is set out on pages 93 to 95. The information in this document does not constitute an offer to sell or an invitation to buy shares in GSK plc or an invitation or inducement to engage in any other investment activities. Past performance cannot be relied upon as a guide to future performance. Nothing in this Annual Report should be construed as a profit forecast. Assumptions and basis of preparation related to 2024 guidance, 2021-26 and 2031 outlooks All guidance, outlooks and expectations should be read together with the guidance and outlooks, assumptions and cautionary statements in this annual report and the Group's Q4 2023 earnings release. In outlining the guidance for 2024 and outlooks for the period 2021-2026 and for 2031, the Group has made certain assumptions about the macro-economic environment, the healthcare sector (including regarding existing and possible additional governmental legislative and regulatory reform), the different markets and competitive landscape in which the Group operates and the delivery of revenues and financial benefits from its current portfolio, its development pipeline and restructuring programmes. 2024 Guidance These planning assumptions as well as operating profit and earnings per share guidance and dividend expectations assume no material interruptions to supply of the Group’s products, no material mergers, acquisitions or disposals, no material litigation or investigation costs for the Company (save for those that are already recognised or for which provisions have been made) and no change in the Group’s shareholdings in ViiV Healthcare. The assumptions also assume no material changes in the healthcare environment or unexpected significant changes in pricing as a result of government or competitor action. The 2024 guidance factors in all divestments and product exits announced to date. 2021-26 and 2031 outlooks The assumptions for GSK’s updated revenue, operating profit, operating margin and cash flow outlooks, 2031 revenue outlook and margin expectations through Dolutegravir loss of exclusivity assume the delivery of revenues and financial benefits from its current and development pipeline portfolio of drugs and vaccines (which have been assessed for this purpose on a risk- adjusted basis, as described further below); regulatory approvals of the pipeline portfolio of drugs and vaccines that underlie these expectations (which have also been assessed for this purpose on a risk-adjusted basis, as described further below); no material interruptions to supply of the Group’s products; successful delivery of the ongoing and planned integration and restructuring plans; no material mergers, acquisitions or disposals or other material business development transactions; no material litigation or investigation costs for the company (save for those that are already recognised or for which provisions have been made); no share repurchases by the company; and no change in the shareholdings in ViiV Healthcare. GSK assumes no premature loss of exclusivity for key products over the period. The assumptions for GSK’s updated revenue, operating profit, operating margin and cash flow outlooks, 2031 revenue outlook and margin expectations through Dolutegravir loss of exclusivity also factor in all divestments and product exits announced to date as well as material costs for investment in new product launches and R&D. Risk-adjusted sales includes sales for potential planned launches which are risk-adjusted based on the latest internal estimate of the probability of technical and regulatory success for each asset in development. Potential future sales contribution from Blenrep has been excluded. Notwithstanding these guidance, outlooks and expectations, there is still uncertainty as to whether our assumptions, guidance, outlooks and expectations will be achieved, including based on the other assumptions outlined above. All outlook statements are given on a constant currency basis and use 2023 average exchange rates as a base (£1/ $1.24, £1/€1.15, £1/Yen 175). 2021-2026 outlook refers to the 5 years to 2026 with 2021 as the base year. Notice regarding limitations on Director Liability under English Law Under the UK Companies Act 2006, a safe harbour limits the liability of Directors in respect of statements in and omissions from the Directors’ Report (for which see page 161), the Strategic report and the Remuneration report. Under English law the Directors would be liable to the company, but not to any third party, if one or more of these reports contained errors as a result of recklessness or knowing misstatement or dishonest concealment of a material fact, but would otherwise not be liable. Pages 97, 131, 166 to 167, and 285 to 314 inclusive comprise the Directors’ Report, pages 1 to 95 inclusive comprise the Strategic report and pages 133 to 164 inclusive comprise the Remuneration report, each of which have been drawn up and presented in accordance with and in reliance upon English company law and the liabilities of the Directors in connection with these reports shall be subject to the limitations and restrictions provided by such law. Website GSK’s website www.gsk.com gives additional information on the Group. Notwithstanding the references we make in this Annual Report to GSK’s website, none of the information made available on the website constitutes part of this Annual Report or shall be deemed to be incorporated by reference herein. 317 We unite science, technology and talent to get ahead of disease together. Head Office and Registered Office GSK plc 980 Great West Road Brentford, Middlesex TW8 9GS United Kingdom Tel: +44 (0)20 8047 5000 Registered number: 3888792 

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