Quarterlytics / Guardion Health Sciences, Inc.

Guardion Health Sciences, Inc.

ghsi · NASDAQ
Claim this profile
Ticker ghsi
Exchange NASDAQ
Sector
Industry
Employees 11-50
← All annual reports
FY2020 Annual Report · Guardion Health Sciences, Inc.
Sign in to download
Loading PDF…
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-K

[X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2020

OR

[  ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ____ to ____

Commission file number: 000-55723

GUARDION HEALTH SCIENCES, INC.
(Exact name of Registrant as specified in its charter)

Delaware
(State or other jurisdiction of
incorporation or organization)

15150 Avenue of Science, Suite 200
San Diego, California 92128
Telephone: 858-605-9055
(Address and telephone number
of principal executive offices)

47-4428421
(I.R.S. Employer
Identification No.)

15150 Avenue of Science, Suite 200
San Diego, California 92128
Telephone: 858-605-9055
Telecopier: (858) 630-5543
(Address and telephone number of principal executive offices)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class
Common Stock, par value $0.001 per share

Trading Symbol(s)
GHSI

Name of each exchange on which registered
The NASDAQ Stock Market LLC

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or Section 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. [X] Yes [  ] No

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of
Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post
such files). [X] Yes [  ] No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an
emerging  growth  company.  See  the  definitions  of  “large  accelerated  filer,”  “accelerated  filer”,  “smaller  reporting  company”,  and  “emerging  growth
company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer
Non-accelerated filer

[  ]
[X]

Accelerated filer
Smaller reporting company
Emerging growth company

[  ]
[X]
[X]

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new
or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. [  ]

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control
over  financial  reporting  under  Section  404(b)  of  the  Sarbanes-Oxley  Act  (15  U.S.C.  7262(b))  by  the  registered  public  accounting  firm  that  prepared  or
issued its audit report. [  ]

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).

[  ] Yes [X] No

On June 30, 2020, the last business day of the registrant’s most recently completed second fiscal quarter, the aggregate market value (based on the closing
per share sales price of its common stock on that date) of the voting stock held by non-affiliates of the registrant was approximately $37.5 million.

As of March 25, 2021, there were 24,426,993 shares of the registrant’s common stock, par value $0.001 per share, issued and outstanding.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
TABLE OF CONTENTS

PART 1

ITEM 1. BUSINESS
ITEM 1A. RISK FACTORS
ITEM 1B. UNRESOLVED STAFF COMMENTS
ITEM 2. PROPERTIES
ITEM 3. LEGAL PROCEEDINGS
ITEM 4. MINE SAFETY DISCLOSURES

PART II

ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES

OF EQUITY SECURITIES

ITEM 6. SELECTED FINANCIAL DATA
ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
ITEM 9A. CONTROLS AND PROCEDURES
ITEM 9B. OTHER INFORMATION

PART III

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
ITEM 11. EXECUTIVE COMPENSATION
ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER

MATTERS

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS AND DIRECTOR INDEPENDENCE
ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES

PART IV

ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

CONSOLIDATED FINANCIAL STATEMENTS AND FOOTNOTES

SIGNATURES

2

Page No.

3
22
41
41
42
42

42
42
42
52
52
52
52
54

54
57

61
62
63

64

F-1

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
FORWARD LOOKING STATEMENTS

This Annual Report on Form 10-K for the fiscal year ended December 31, 2020 contains “forward-looking statements” within the meaning of the Securities
Act  of  1933,  as  amended  (the  “Securities  Act”),  and  the  Securities  Exchange  Act  of  1934,  as  amended  (the  “Exchange  Act”).  These  forward-looking
statements contain information about our expectations, beliefs or intentions regarding our product development and commercialization efforts, business,
financial condition, results of operations, strategies or prospects, and other similar matters. These forward-looking statements are based on management’s
current expectations and assumptions about future events, which are inherently subject to uncertainties, risks and changes in circumstances that are difficult
to  predict.  These  statements  may  be  identified  by  words  such  as  “expects,”  “plans,”  “projects,”  “will,”  “may,”  “anticipates,”  “believes,”  “should,”
“intends,” “estimates,” and other words of similar meaning.

Actual results could differ materially from those contained in forward-looking statements. Many factors could cause actual results to differ materially from
those in forward-looking statements, including those matters discussed below, as well as those listed in Item 1A. Risk Factors.

Other unknown or unpredictable factors that could also adversely affect our business, financial condition and results of operations may arise from time to
time. Given these risks and uncertainties, the forward-looking statements discussed in this report may not prove to be accurate. Accordingly, you should not
place undue reliance on these forward-looking statements, which only reflect the views of the Company’s management as of the date of this report. We
undertake no obligation to update or revise forward-looking statements to reflect changed assumptions, the occurrence of unanticipated events or changes
to future operating results or expectations, except as required by law.

ITEM 1. BUSINESS

PART I

Throughout  this  Annual  Report  on  Form  10-K,  the  terms  “we,”  “us,”  “our,”  “our  company,”  “Guardion”  the  “Company”  and  the  “Registrant”  refer  to
Guardion Health Sciences, Inc. and its consolidated subsidiaries.

Overview

The Company is a specialty health sciences company (1) that has developed medical foods and medical devices in the ocular health space and (2) that is
developing nutraceuticals that the Company believes will provide supportive health benefits to consumers.

Medical Foods:

● Lumega-Z®: The Company formulates and distributes Lumega-Z®, which is designed to replenish and restore the macular protective pigment. A
depleted macular protective pigment is a modifiable risk factor for retina-based diseases such as adult dry macular degeneration (“AMD”) and
computer  vision  syndrome  (“CVS”).  The  Company  believes  this  risk  may  be  modified  by  taking  Lumega-Z  to  maintain  a  healthy  macular
protective  pigment.  Additionally,  early  research  has  shown  a  depleted  macular  protective  pigment  to  be  a  biomarker  for  neurodegenerative
diseases such as Alzheimer’s disease and dementia.

● GlaucoCetinTM  :  In  November  2018,  the  Company  launched  its  second  medical  food  product,  GlaucoCetinTM.  The  Company  believes
GlaucoCetinTM  is  the  first  vision-specific  medical  food  designed  to  support  and  protect  the  mitochondrial  function  of  optic  nerve  cells  and
improve  blood  flow  in  the  ophthalmic  artery  in  patients  with  glaucoma.  The  parent  compound  of GlaucoCetinTM,  called  “GlaucoHealth,”  was
designed by Robert Ritch, M.D., one of the Company’s Medical Advisory Board members.

3

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Medical Devices:

● MapcatSF®: In 2016, the Company acquired the rights to a proprietary technology, embodied in the Company’s medical device, the MapcatSF®,
which  measures  the  macular  pigment  optical  density  (“MPOD”).  On  November  8,  2016,  the  United  States  Patent  and  Trademark  Office
(“USPTO”) issued patent number 9,486,136 for the MapcatSF invention. Using the MapcatSF to measure the MPOD allows one to monitor the
increase in the density of the macular protective pigment after taking Lumega-Z. The MapcatSF device is a Class I medical device under the U.S.
Food  and  Drug  Administration  (“FDA”)  classification  scheme  for  medical  devices,  which  the  Company  has  determined  does  not  require  pre-
market  approval.  The  Company’s  focus  is  to  deploy  the  MapcatSF  in  clinics  accompanied  by  trained  technicians  to  conduct  the  MPOD
measurements and collaborate with  the  physicians  treating  their  patients.  The  Company  maintains  ownership  and  possession  of  the  MapcatSF
when used in this fashion, but will sell the device to physicians upon request.

● VectorVision, CSV-1000 and CSV-2000: In September 2017, the Company, through its wholly owned subsidiary VectorVision Ocular Health,
Inc.,  acquired  substantially  all  of  the  assets  and  certain  liabilities  of  VectorVision,  Inc.,  a  company  that  specializes  in  the  standardization  of
contrast  sensitivity,  glare  sensitivity,  low  contrast  acuity,  and  early  treatment  diabetic  retinopathy  study  (“ETDRS”)  visual  acuity  testing.
VectorVision’s standardization system(s) are designed to provide the practitioner or researcher with the ability to delineate very small changes in
visual capability, either as compared to the population or from visit to visit. VectorVision develops, manufactures and sells equipment and supplies
for  standardized  vision  testing  for  use  by  eye  doctors  in  clinics,  for  researchers  to  use  in  clinical  trials,  for  real-world  vision  evaluation,  and
industrial vision testing. The acquisition expands the Company’s technical portfolio.

In  September  2019,  the  Company  announced  that  it  completed  development  of  its  new  proprietary,  digital  CSV-2000  standardized  contrast
sensitivity testing device. The Company believes that the CSV-2000 is the only computer-generated vision testing instrument available that will
provide  the  optical  marketplace  with  the  Company’s  proprietary,  industry-standard  contrast  sensitivity  test,  along  with  a  full  suite  of  standard
vision testing protocols. The proprietary standardization methodology incorporated into the CSV-2000 includes a patented technology known as
AcQviz, embodied in its own device, that automatically and constantly measures and adjusts screen luminance to a fixed standard light level for
vision testing. The Company began selling the new CSV-2000 and AcQviz devices at the end of the first quarter of 2020 but was impacted by
COVID-19.  The  Company  plans  to  put  significant  focus  on  sales  and  marketing  efforts  of  the  new  CSV-2000,  although  the  CSV-1000  will
continue to be sold. The Company believes the VectorVision product portfolio further establishes the Company’s position at the forefront of early
detection, intervention and monitoring of a range of eye diseases.

Nutraceuticals:

● NutriGuard Acquisition:  In  September  2019,  the  Company  acquired  NutriGuard  Research,  Inc.  The  Company  intends  to  build  a  portfolio  of
nutraceutical products under the NutriGuard brand by developing new formulations and marketing its products to patients directly through direct
to consumer (“DTC”) channels and through recommendations by their physicians.

● ImmuneSF: The first new nutraceutical product developed after the acquisition of NutriGuard is ImmuneSF, a unique proprietary nutraceutical
formulation designed to support and maintain an effective immune system. This formulation contains a synergistic blend of antioxidant and anti-
inflammatory nutrients. The Company has arranged for the manufacture and packaging of ImmuneSF at contract facilities in the United States and
began  marketing  the  product  during  the  second  quarter  of  2020.  The  Company  anticipates  that  ImmuneSF  will  also  be  exported  for  sales  in
international markets.

● In addition to NutriGuard’s ImmuneSF product, a Malaysian company contracted with NutriGuard to develop a proprietary formula to meet the
demands of the Malaysian company’s customers for an immune-supportive product. Each unit of the product consists of two (2) bottles packaged
together,  one  named  Astramern-H  and  one  named  Astramern-V.  The  formula  is  designed  to  provide  both  immuno-supportive  and  anti-
inflammatory benefits to its users.

4

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Recent Developments

January and February 2021 At the Market Offerings

On January 8, 2021, we filed a prospectus supplement pursuant to which we could sell up to $10,000,000 worth of shares of our common stock in an “at
the market” offering (the “January 2021 1st ATM Offering”). On January 15, 2021, we completed the January 2021 1st ATM Offering, pursuant to which
we sold an aggregate of 2,559,834 shares of our common stock, raised gross proceeds of approximately $10,000,000 and net proceeds of approximately
$9,500,000.

On January 28, 2021, we filed a prospectus supplement pursuant to which we could sell up to $25,000,000 worth of shares of our common stock in an “at
the  market”  offering  (the  “January  2021  2nd  ATM  Offering”).  On  February  10,  2021,  we  completed  the  January  2021  2nd  ATM  Offering,  pursuant  to
which  we  sold  an  aggregate  of  5,006,900  shares  of  our  common  stock,  raised  gross  proceeds  of  approximately  $25,000,000  and  net  proceeds  of
approximately $24,100,000.

In  addition,  in  January  and  February  2021,  the  Company  issued  an  aggregate  of  1,647,691  shares  of  common  stock  upon  the  exercise  of  warrants  and
received cash proceeds of $3,608,509.

Appointment of New CEO

Effective as of January 6, 2021, the Board of Directors appointed Bret Scholtes as President and Chief Executive Officer and as a director of the Company.

Prior to his appointment, Mr. Scholtes, age 51, served as the President and Chief Executive Officer of Omega Protein Corporation (“Omega”) since 2012
and as a director of Omega since 2013. Omega was listed on The New York Stock Exchange until January 2018 when it was sold. Prior to his selection as
Chief Executive Officer of Omega, Mr. Scholtes served as the Omega’s Senior Vice President-Corporate Development from April 2010 to December 2010
and as Omega’s Executive Vice President and Chief Financial Officer from January 2011 to December 2011. From 2006 to April 2010, Mr. Scholtes served
as a Vice President at GE Energy Financial Services, a global energy investment firm. Prior to that, Mr. Scholtes held positions with two publicly traded
energy  companies.  Mr.  Scholtes  also  has  five  years  of  public  accounting  experience.  Mr.  Scholtes  holds  an  MBA  degree  in  Finance  from  New  York
University and a degree in Accounting from the University of Missouri – Columbia.

Reverse Stock Split and Nasdaq Compliance

On September 20, 2019, we received notice from the Listing Qualifications staff (the “Staff”) of The Nasdaq Stock Market LLC (“Nasdaq”) indicating that,
based  upon  the  closing  bid  price  of  the  Company’s  common  stock  for  the  previous  30  consecutive  business  days,  the  Company  no  longer  satisfied  the
requirement to maintain a minimum bid price of $1.00 per share, as required by Nasdaq Listing Rule 5550(a)(2) (the “Bid Price Rule”). In accordance with
the Nasdaq Listing Rules, the Company was afforded 180 days, or until March 18, 2020, to regain compliance with the Bid Price Rule by evidence of a
closing bid price of at least $1.00 per share for a minimum of 10 consecutive business days. Thereafter, the Company had been afforded a second 180-
calendar day compliance period (which 180-day period was extended due to circumstances related to COVID-19), or until November 30, 2020, to regain
compliance with the Bid Price Rule.

The Company was unable to regain compliance with the Bid Price Rule by November 30, 2020. Accordingly, on December 1, 2020, the Company received
a  letter  from  the  Staff  notifying  it  that  its  Common  Stock  would  be  subject  to  delisting  from  Nasdaq  unless  the  Company  timely  appealed  Nasdaq’s
determination to a Nasdaq Listing Qualifications Panel (the “Panel”). The Company timely appealed Nasdaq’s determination to the Panel.

On January 26, 2021, the Company received written notification that the Panel granted the Company an extension for continued listing through March 15,
2021. 

On March 1, 2021, the Company filed a Certificate of Amendment to its Certificate of Incorporation, as amended, with the Secretary of State of the State of
Delaware  to  effectuate  a  one-for-six  (1:6)  reverse  stock  split  (the  “Reverse  Stock  Split”)  of  its  common  stock  without  any  change  to  its  par  value.
Proportional adjustments for the Reverse Stock Split were made to the Company’s outstanding common stock, stock options, and warrants as if the split
occurred at the beginning of the earliest period presented in this Annual Report.

5

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
On March 15, 2021, we received a letter from the Staff notifying us that we had regained compliance with the Bid Price Rule. The letter stated the staff had
determined that for the prior 10 consecutive business days, from March 1, 2021 to March 12, 2021, the closing bid price of the Company’s common stock
had  been  at  $1.00  per  share  or  greater  and  that  accordingly,  the  Company  had  regained  compliance  under  the  Bid  Price  Rule,  and  that  the  matter  was
closed.

Background

Medical Foods

Medical foods are regulated as foods under the federal Food, Drug, and Cosmetic Act. The Company believes that there is an increasing level of acceptance
of medical foods as a primary therapy by patients and healthcare providers to manage pain syndromes, sleep and cognitive disorders, obesity, hypertension,
and  viral  infection.  In  clinical  practice,  medical  foods  are  being  prescribed  as  both  a  standalone  therapy  and  as  an  adjunct  therapy  to  low  doses  of
commonly prescribed drugs. The Company believes that medical foods will continue to grow in importance over the coming years.

Lumega-Z®  is  a  medical  food  product  that  has  a  patent-pending  formula  that  is  designed  to  replenish  and  restore  the  macular  protective  pigment
simultaneously delivering critical and essential nutrients to the eye. Management believes, based on review of products on the market and knowledge of the
industry,  that  Lumega-Z  is  the  first  liquid  ocular  health  formula  to  be  sold  as  a  medical  food  (as  defined  in  Section  5(b)  of  the  “Orphan  Drug  Act”).
However, the FDA has not monitored nor approved Lumega-Z as a medical food. Formulated by Dr. Sheldon Hendler in 2010, modifications were made
over the lifetime of the formula to improve the efficacy, taste, and method of delivery. The current formulation has been delivered to patients and used in
clinics since 2019.

Lumega-Z  must  be  administered  under  the  supervision  of  a  physician  or  professional  healthcare  provider.  In  order  to  reach  the  large,  expanding AMD
patient population, the Company primarily has marketed Lumega-Z to patients through ophthalmologists and optometrists. The Company intends to also
market Lumega-Z through direct-to-consumer strategies such as, television, social media and paid search advertising.

Lumega-Z® has  published  two  peer-review  scientific  articles,  demonstrating  its  beneficial  efficacy,  in  2020.  Both  articles  were  published  in  the  journal
Nutrients.  The  first  published  study  assessed  the  level  of  absorption  of  the  carotenoids  in  Lumega-Z  compared  to  absorption  of  the  carotenoids  in  the
industry  leading  eye  vitamin,  PreserVisionTM  (AREDS  2  formula  sold  by  Bausch  and  Lomb),  and  determined  whether  an  elevated  level  of  carotenoid
absorption  leads  to  increased  MPOD.  The  study  found  that  despite  only  a  2.3-fold  higher  carotenoid  concentration  than  PreserVisionTM,  Lumega-Z
supplementation  provides  approximately  3–4-fold  higher  absorption,  which  leads  to  a  significant  elevation  of  MPOD  levels  (Nutrients  2020,  12,  132:
Published May 2, 2020).The second study evaluated the visual benefits in a group of patients taking Lumega-Z compared to a group of patients taking
AREDS 2 (PreserVisionTM) soft gel supplements, as well as a third control group taking no supplementation.. Each study participant had retinal drusen,
significantly delayed dark adaptation recovery time and was at risk of developing vision loss from AMD. The results showed significant improvements in
visual function, as measured by contrast sensitivity, in the group of patients taking Lumega-Z. The patients taking PreserVisionTM showed a trend toward
an improvement, but no statistical change, while the control group showed no change. (Nutrients 2020, 12, 3271: Published October 26, 2020).

6

 
 
 
 
 
 
 
 
 
Sales of Lumega Z remained flat throughout 2020, as many eye doctor offices were closed, or operating with limited capacity, due to COVID-19 related
“shelter at home” orders.

GlaucoCetin is the Company’s second medical food. It offers a patent-pending formula that is designed to support proper mitochondrial function in the
optic nerve cells of glaucoma patients. Loss of optic nerve cells is thought to be the primary cause of vision loss in glaucoma patients. Like Lumega-Z,
GlaucoCetin  has  also  been  distributed  primarily  through  eye  doctors,  however,  the  Company  plans  to  offer  direct-to-consumer  marketing  programs.
GlaucoCetin sales grew by 112% during 2020. The Company believes this growth rate, despite COVID-19 related issues affecting patient access to eye
doctor offices, is due to limited competition for glaucoma related nutritional products and a wider acceptance by clinicians of the potential efficacy of the
nutritional therapies.

Vision loss from eye disease is a rapidly growing problem in the United States and across the globe. The National Academics of Sciences, Engineering, and
Medicine projects that “every four minutes, one American will experience partial or complete loss of sight.” According to The Lancet, AMD cases in the
US are projected to pass 18 million in 2017, and 20 million by 2022. According to an EpiCast Report, the number of glaucoma patents is expected to grow
yearly by 15% and for there to be 15.7 million cases worldwide by 2023, with most of these cases in the United States and Japan.

The US Food and Drug Administration (FDA) took steps in 1988 to encourage the development of medical foods by creating a regulatory category for
medical foods under the Orphan Drug Act. The term “medical food” as defined in Section 5(b) of the Orphan Drug Act is a “food which is formulated to be
consumed or administered enterally (by mouth) under the supervision of a physician and which is intended for the specific dietary management of a disease
or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.” This definition
was incorporated by reference into the Nutrition Labeling and Education Act of 1990.

The field of candidates for development into medical foods is expanding due to continuing advances in the understanding of the science of nutrition and
disease, coupled with advances in food technology thereby increasing the number of products that can be formulated and commercialized. The Company
distributes its medical food products through E-commerce in an online store that is operated at www.guardionhealth.com. Information about VectorVision
products can be found at www.vectorvision.com. Information about NutriGuard Formulations products can be found at www.nutriguard.com.

The  Company  also  distributes  its  medical  foods  products  through  E-commerce  in  an  online  store  that  is  operated  at  www.guardionhealth.com.  The
Company plans to expand its E-commerce capabilities in 2021.

Medical  foods  consist  of  food-based  ingredients  that  are  part  of  the  normal  human  diet  and  are  Generally  Recognized  as  Safe  (“GRAS”)  under  FDA
standards.  Medical  foods  must  make  claims  for  which  there  is  scientific  evidence  that  nutrient  deficiencies  cannot  be  corrected  by  normal  diet.  All
ingredients must be designated GRAS and used in therapeutic concentrations to address the particular nutritional needs of the patient. Medical foods are
taken  under  the  supervision  of  a  physician  or  professional  healthcare  provider  who  monitors  and  adjusts  the  food  ‘dosage.’  In  addition,  under  FDA
guidelines and congressionally approved laws, medical foods do not require FDA preapproval but undergo continuous FDA monitoring and approval of
label claims. Even though pre-market FDA approval is not required for a medical food, the official requirements and responsibilities for the manufacturer,
in terms of safety, are greater than for dietary supplements, including solid scientific support for the formula as a whole. For these reasons, medical foods
have greater guarantees of efficacy. In contradistinction, dietary supplements, such as vitamins, minerals and botanicals, do not require FDA preapproval,
cannot make disease claims, are intended for normal people without disease or a condition and cannot claim that they prevent, mitigate or treat a given
disease or condition. Dietary supplements do not require physician supervision and can be self-administered without supervision.

7

 
 
 
 
 
 
 
 
 
The Company believes that Lumega-Z and GlaucoCetin are properly categorized as medical foods. While the Company believes it is unlikely the FDA
would conclude otherwise, if the FDA determines Lumega-Z or GlaucoCetin should not be defined as a medical food, the Company would need to relabel
and rebrand that product. The Company believes there would be minimal impact on its operations and financial condition if it were required to change
labeling  and  packaging  to  that  of  a  dietary  supplement.  While  reclassification  and  the  subsequent  relabeling  and  rebranding  would  be  an  added  cost  to
operations, it would not change the use or effectiveness of Lumega-Z or GlaucoCetin, although there is a chance that certain physicians may choose not to
recommend Lumega-Z or GlaucoCetin to their patients or that certain consumers may choose not to buy Lumega-Z or GlaucoCetin if they are not classified
as medical foods.

Medical Devices

The Company believes that consistent, repeatable and accurate results for visual acuity testing are of paramount importance for effective eye health care
and for accurately establishing and enforcing the vision performance criteria required for certain professions. Variance in test lighting is a major cause of
inconsistency in vision testing results. Standards for testing luminance, have been in place for more than three decades. However, recently, vision testing
has evolved from the use of projection systems and charts to the use of digital displays. The Company believes that the variance in luminance provided by
digital displays is large, and clinicians are now obtaining highly inconsistent results from practice to practice. Conservatively, the Company believes more
than 250,000 eye care examination rooms are in use in the United States today.

The  variability  described  above  has  caused  the  FDA  and  other  agencies  to  require  standardized  test  lighting  for  vision  tests.  Because  VectorVision
specializes  in  the  standardization  of  vision  tests,  VectorVision  is  the  only  company  that  offers  fully  standardized  vision  testing  products  that  ensure
consistent, repeatable and highly accurate results using automated light calibration systems. The CSV-1000 device offers auto-calibrated tests to ensure the
correct testing luminance and contrast levels for consistent, highly accurate and repeatable results, which is why the VectorVision instruments can detect
and quantify subtle changes in vision. Consistency, repeatability and accuracy are also why the VectorVision CSV-1000 instrument is used worldwide by
eye doctors in more than 60 countries to accomplish contrast sensitivity testing. The Company’s research has revealed there are no competing products that
offer auto-calibration of ambient illumination or test lighting. Competitive devices do not correct for variations in test light levels, resulting in variability of
test results. The CSV-1000 uses self-calibrated test lighting. The self-calibrated test lighting is proprietary. For the CSV-2000, the follow-on computerized
device for the CSV-1000, the self-calibrated test lighting technology is a proprietary and patented technology known as AcQviz, which constantly measures
the luminance of the CSV-2000 computer screen and automatically adjusts screen luminance to a fixed standard light level for vision testing. The test faces
of the CSV-1000 are proprietary, and their intellectual property is protected under copyright and trade secret law. CSV-1000 is currently sold worldwide,
and the Company expects this global distribution to continue. The first sale of the CSV-2000 occurred in Q1, 2020 and the Company believes this product
will also be sold worldwide. There is a training requirement for incorporating the CSV-1000 and the CSV-2000 device into clinical practice, which the
Company plans to provide as part of its commercialization strategy.

The MapcatSF device offers a proprietary technology to effectively evaluate the MPOD, which is a measure of the health of the macular pigment. The
MapcatSF device is used primarily in eye doctor’s offices as a means to demonstrate to patients the current status of their MPOD and the potential benefits
of Lumega-Z after treatment. The first MapcatSF was sold in 2020. No major sales and marketing strategy is currently planned for the direct sales of the
device, as it will be used more as a measurement tool to educate patients and their eye doctors about the need for taking Lumega-Z to replenish the macular
pigment. The MapcatSF will be sold to doctors or researchers upon request.

Nutraceutical Industry Overview

A dietary supplement is a defined in the Dietary Supplement Health and Education Act, enacted in 1994 (“DSHEA”), as “a product (other than tobacco)
intended  to  supplement  the  diet  that  bears  or  contains  one  or  more  of  the  following  dietary  ingredients:  vitamins,  minerals,  amino  acids,  herbs  or  other
botanicals;  a  concentrate,  metabolite,  constituent,  extract  or  combination  of  the  ingredients  listed  above.  Dietary  supplements  are  intended  to  be  taken
orally and are labeled on the front panel as being a dietary supplement.

DSHEA  places  dietary  supplements  in  a  special  category  under  the  general  umbrella  of  “foods,”  not  drugs,  and  requires  the  product  to  be  labeled  as  a
“dietary supplement.” The terms “dietary supplement” and “nutraceutical” are often used interchangeably.

8

 
 
 
 
 
 
 
 
 
 
Under DSHEA, a company is responsible for determining that the dietary supplements it manufactures or distributes are safe and that any representations
or claims made about them are substantiated by adequate evidence to show that they are not false or misleading. Dietary supplements do not need approval
from FDA before they are marketed, although “new dietary ingredients” do require premarket review by FDA. This allows companies to bring products to
market in less time and with less cost than is required for drug approval from the FDA.

Competitive Advantage and Strategy

Medical Foods

There are no research-validated pharmaceutical solutions for slowing the progression of adult dry macular degeneration (“AMD”). As a result, physicians
often recommend Age-Related Eye Disease Study (“AREDS”)-based supplements to early AREDS-based AMD patients. However, more than 90% of all
AREDS-based nutritional products currently on the market are in tablet, capsule or gel capsule form, which have a low efficiency of absorption.

Lumega-Z is a medical food designed to enhance the bioavailability of “difficult to absorb” ingredients like carotenoids. In contrast to other formulations,
Lumega-Z  is  a  liquid  formulated  using  a  proprietary  molecular  micronization  process  (“MMP”)  to  maximize  efficiency  of  absorption  and  to  minimize
compatibility issues. The MMP is a proprietary homogenization process whereby the particle size of the ingredients is reduced to facilitate more efficient
absorption  into  the  body.  As  noted  earlier,  clinical  studies  have  shown  Lumega-Z  offers  significantly  higher  absorption  of  carotenoids,  than  the  leading
AREDS-based  formula  PreserVisionTM  (Nutrients,  12,  1321:  Published  May  2,  2020).  In  a  subsequent  study,  Lumega-Z  was  also  found  to  provide
significantly better vision benefit than the AREDS-based formula in patients with drusen and at risk of vision loss from AMD, as measured by contrast
sensitivity (Nutrients 12, 3271: Published October 26, 2020). The Company believes we have a competitive advantage with Lumega-Z because of these
two published studies showing superiority over the leading formula, PreserVisionTM, and because a growing body of evidence, particularly the results from
the AREDS studies, that has demonstrated the importance of supplementation with carotenoids to offset vision loss in patients with macular degeneration.
Lumega-Z  has  demonstrated  in  studies  to  have  higher  absorption  of  carotenoids,  which  the  Company  believes  leads  to  better  visual  outcomes,  and  a
superiority over the competitive formulas.

GlaucoCetin is a medical food designed to support mitochondrial function in the optic nerve cells of glaucoma patients. For glaucoma, the primary risk
factor for disease progression has been thought to be elevated intraocular pressure which in turn damages the optic nerve cells leading to vision loss. As
such, the primary means for treating the disease, to slow or stop vision loss, is to lower the intraocular pressure through pharmaceutical or surgical means.
However, new studies suggest that many glaucoma patients do not exhibit elevated intraocular pressure. Further, many patients who have displayed high
intraocular pressure and have been treated to lower the pressure, continue to lose vision. These trends have led clinicians and researchers to suggest that
other mechanisms of disease progression are occurring, one of which is mitochondrial dysfunction of optic nerve cells. The Company believes we have a
competitive advantage with GlaucoCetin because it is the first to market medical food specifically designed to offset the mitochondrial dysfunction of cells
in glaucoma patients.

Medical Devices

VectorVision specializes in the standardization of vision tests, specifically, contrast sensitivity, glare testing and early treatment diabetic retinopathy study,
or  ETDRS,  acuity.  The  variability  in  test  lighting  has  caused  the  FDA  and  other  agencies  to  require  standardized  test  lighting  for  vision  tests.  Contrast
sensitivity  testing  measures  how  people  see  in  the  real  world.  A  depleted  macular  pigment  greatly  affects  contrast  sensitivity.  Research  suggests  that
contrast  sensitivity  is  a  better  measure  than  standard  acuity  tests  for  real-world  vision  applications  such  as  military  pilots  and  highway  driving.  The
Company believes that VectorVision is the only company that offers fully standardized vision testing products that ensure consistent, repeatable and highly
accurate results. These qualities are why the VectorVision instruments can detect and quantify subtle changes in vision, and why the VectorVision CSV-
1000 instrument is used worldwide by eye doctors in more than 60 countries to accomplish contrast sensitivity testing. On July 10, 2018, the USPTO issued
US  Patent  No.  10,016,128,  titled  Method  and  Apparatus  for  Visual  Acuity  Testing.  This  patent  describes  an  invention  pertaining  to  automatic  light
calibration of the display screens used for vision testing. The Company has acquired the exclusive rights to this patent, and its VectorVision CSV-2000
device  embodies  this  invention.  On  July  17,  2018,  the  USPTO  issued  US  Patent  No.  10,022,045,  also  titled  Method  and  Apparatus  for  Visual  Acuity
Testing, which describes a methodology to continuously calibrate display monitors to automatically hold display luminance constant for vision testing. This
second patent also covers a methodology to compensate for other testing factors, such as room illumination and when patients view the vision test through
a mirror, which is a common practice in eye doctors’ offices worldwide. The Company also acquired the rights to this patent. The Company’s new AcQviz
device embodies this invention, which is now used in conjunction with the VectorVision CSV-2000 device.

9

 
 
 
 
 
 
 
 
 
 
The Company believes the CSV-1000 is the current standard of care for testing contrast sensitivity in clinical practice. The first sale of the CSV-2000 was
made in February 2020. There is a training requirement in incorporating the CSV-1000 and CSV-2000 device into clinical practice, which the Company
plans to provide as part of its commercialization strategy.

The  CSV-1000  and  CSV-2000  offer  self-calibrated  test  lighting  for  vision  testing.  The  self-calibrated  test  lighting  technology  for  both  instruments  is
proprietary  to  the  Company.  The  patented  technology  known  as  AcQviz,  applies  to  the  CSV-2000.  It  constantly  measures  the  luminance  of  the  display
monitor  of  the  CSV-2000  and  automatically  adjusts  screen  luminance  to  a  fixed  standard  light  level  for  vision  testing.  Although  the  CSV-1000  will
continue to be sold, the Company plans to put a greater focus on sales and marketing efforts on the new CSV-2000. There can be no assurances that the
marketing efforts will be successful, and sales of the CSV-2000 will be comparable or exceed sales of the CSV-1000. The Company believes we have a
competitive advantage because of the unique and proprietary vision testing luminance standardization technologies employed by the CSV-1000 and CSV-
2000. This standardization has led to the publication of many research studies showing the accuracy of the contrast sensitivity testing protocol used in both
the CSV-1000 and CSV-2000, and to the publication of population normal ranges for contrast sensitivity. The Company believes that there are no other
devices with published normative values for contrast sensitivity.

Nutraceuticals

The Company intends to build a portfolio, in addition to the current product line, of nutraceutical products under the NutriGuard brand by developing or
acquiring new condition-specific formulations. NutriGuard markets these products to patients directly through direct-to-consumer (“DTC”) channels. The
Company also intends to conduct research and publish papers demonstrating the efficacy of the NutriGuard products, which the Company believes will also
lead to distribution of products to patients through recommendations by their physicians.

NutriGuard  intends  to  formulate  high  quality  scientifically  credible  nutraceuticals  with  a  goal  to  become  a  globally  respected  and  physician-preferred
nutraceuticals brand. The Company believes its nutraceuticals can play an important role in optimizing, preserving and restoring health.

Growth Strategy

The Company believes that marketing its products is critical in ensuring its success. The Company has several marketing initiatives and will implement
them according to the success and product feedback that the Company and products create. Marketing initiatives will include not only distribution through
eye  doctor  recommendation,  but  also  direct-to-consumer  programs.  The  Company  will  also  explore  acquiring  other  companies,  product  lines  and
intellectual property that may be complementary or supplementary as part of its efforts to expand the business, which acquisitions could be for cash, stock
or a combination thereof.

Sales Force

The  Company  plans  to  use  a  combination  of  digital  strategies,  virtual  communication,  direct-to-consumer  campaigns  and  direct  sales  activity  with  eye
doctors to promote its products. At the end of 2020, the Company had two highly experienced sales personnel, both Doctors of Naturopathy. During 2021,
the Company intends to add sales team members in the field to conduct direct sales activities for eye doctors, to perform virtual educational campaigns for
practice follow-up with doctors and their staffs and to support the direct-to-consumer campaigns. The Company also intends to initiate significant follow-
on communication activity with patients who have begun taking the nutritional products, to spur higher compliance and patient retention.

10

 
 
 
 
 
 
 
 
 
 
 
International Expansion Strategy

The Company intends to continue to pursue strategies for distribution of its existing products and unique nutritional formulations in Asian markets. In the
quarter ended March 31, 2020, the Company received its first order for a novel immune support product from the Malaysian company, Ho Wah Genting
Berhad “HWGB.” The order was subsequently delivered in the quarter ended June 30, 2020. The total order value was $890,000. The Company also has
several products under development for the U.S. market, most notably a vision support and energy drink known as EPIQ-V, which the Company believes it
may be successfully distributed in Asia.

Ocular Care

Based on management’s knowledge of the industry, the Company believes that Lumega-Z and GlaucoCetin are the only medical foods in the ocular health
space. Thus, with regard to the ocular health market no such data is available regarding medical foods. In an attempt to illustrate the market potential for
Lumega-Z  and  GlaucoCetin,  the  Company  has  examined  ocular  health  products  in  the  dietary  supplement  market  as  the  closest  appropriate  data  set
available.  The  use  of  dietary  supplements  to  enhance  health  and  well-being  is  a  longstanding  and  increasing  trend.  According  to  the  Council  for
Responsible Nutrition, 73% of adults in the United States reported taking dietary supplements in 2020. According to Global Newswire, worldwide sales of
supplements  is  estimated  to  reach  $230.73  billion  by  2027.  Supplementation  has  recently  generated  much  interest  among  eye  health  professionals,  due
largely to the publication of the AREDS study, which was supported by the prestigious US National Eye Institute, showing nutrition can potentially slow
the AMD epidemic.

U.S. Statistics

● According to Ocular Surgery News, there are 4 million cataract surgeries in the United States each year.
● According to the CDC, more than 3 million Americans are living with glaucoma, and this number is expected to rise to 6.3 million by 2050.
● According to the American Glaucoma Society, glaucoma is the second leading cause of blindness and accounts for 9-12% of all cases of blindness

in the U.S.

● According to BrightFocus Foundation, 11 million Americans have AMD, and the number is expected to double to nearly 22 million by 2050.
● According to Am Fam Physician, one in three people in the U.S. over age 65 will develop some form of vision-reducing eye disease with AMD

being the top cause of critical vision loss and legal blindness.

●  

Worldwide Statistics

● According to  Grand  View  Research,  the  “Global  Medical  Foods  Market”  was  valued  at  $20.15  billion  in  2020.  North  America  dominated the

global market revenue with 29.9% of the 2020 total.

● According to the International Council of Ophthalmology, AMD is the third leading cause of blindness throughout the world, exceeded only by

cataracts and glaucoma.

● A meta-analysis by Tham et al. indicated that globally, the number of people with glaucoma was estimated to be 64.3 million in 2013, increasing

to 76.0 million in 2020 and projected to be 111.8 million in 2040.

● According to Globe Newswire, the global glaucoma therapeutics market was valued at $6.59 billion in 2018 and is projected to reach $7.34 billion

by 2026.

● According to Daxue Consulting, in 2018, approximately 25 million elderly people had AMD in China.
● BrightFocus Foundation has indicated that globally, 196 million people had AMD in 2020 and the number is expected to increase to 288 million

by 2040.

● In 2020, BrightFocus Foundation estimated the global cost of visual impairment due to AMD was $343 billion, including $255 billion in direct
health  care  costs.  It  further  estimated  the  direct  health  care  costs  of  visual  impairment  due  to  AMD  in  the  U.S.,  Canada  and  Cuba  to  be
approximately $98 million.

● In 2020,  BrightFocus  Foundation  estimated  the  global  cost  of  vision  loss,  due  to  all  causes,  to  be  nearly  $3  trillion  for  the  733  million  people
living  with  low  vision  and  blindness  worldwide.  BrightFocus  Foundation  also  estimated  the  direct  costs  for  vision  loss  due  to  all  causes  was
$512.8 billion in North America alone, with indirect costs of $179 billion.

11

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
● Expert Market Research indicates that the global market for AMD treatments was $1.58 billion in 2020 and is projected to reach $2.64 billion by

2026.

● According to Sina and Daily Headlines, there are roughly 44,800 Ophthalmologists and 4,000 Optometrists in China, respectively.
● The prevalence of AMD appears to be lower and more variable in the developing nations as compared to more developed countries. Healthcare
experts  believe  this  will  likely  change  for  the  worse  with  increasing  life  expectancy,  changing  lifestyles  and  increase  in  viewing  computer
monitors and other devices.

Due to an aging population, the AMD, Glaucoma and Cognitive Decline epidemics are growing, creating a significant market for the Company’s products.

Marketing Lumega-Z to Practitioners

In  order  to  reach  the  large,  expanding  AMD  patient  population,  the  Company  has  primarily  marketed  Lumega-Z  and  GlaucoCetin  to  patients  through
ophthalmologists and optometrists. In the U.S. alone, there are more than 19,216 ophthalmologists and over 44,000 optometrists currently practicing. There
are more than 213,000 ophthalmologists worldwide. This marketing reach will be achieved through a combination of collaboration with industry-specific
publishers,  peer-to-peer  promotion  using  key  opinion  leader  clinicians,  organic  and  paid  search  engine  optimization  and  marketing,  and  other  content-
driven & educational approaches.

The MapcatSF®  has  demonstrated  itself  to  be  an  effective  tool  to  promote  Lumega-Z.  The  Company  has  determined  that  the  value  of  the  MapcatSF  is
through this utilization. The Company intends, as part of its efforts to directly target eye doctors as part of its marketing strategies, to continue to deploy the
MapcatSF in this fashion, with a focus of assigning the MapcatSF to clinics to build and maintain relationships with the clinics and assist the physicians in
making a determination to recommend Lumega-Z to their patients. The Company believes that continued deployment of MapcatSF devices in this fashion
will build effective relationships with physicians and their clinics, expand the awareness of the Company’s products and increase sales of Lumega-Z.

As  noted  earlier,  these  marketing  efforts  targeting  eye  doctors  will  be  supplemented  by  a  variety  of  direct-to-consumer  campaigns  and  the  use  of  more
efficient and cost-effective virtual strategies for educating and connecting with consumers.

Marketing the CSV-1000 and CSV-2000 to Practitioners

Contrast sensitivity is currently one of the standard tests for clinical trials relating to ocular surgeries and treatments, and the CSV-1000 is considered the
benchmark  for  these  applications.  In  addition,  there  is  an  increasing  need  for  functional  vision  assessment  in  everyday  clinical  practice,  as  a  means  of
measuring  the  effect  of  disorders  such  as  cataract  and  macular  degeneration  on  the  patient’s  functional  vision,  and  the  impact  of  treatment  of  these
conditions on the patient’s vision. The Company will concentrate its efforts on increasing the use of contrast sensitivity in everyday clinical practice, as a
means of targeting the optometry and ophthalmology markets, which consists of over 34,000 and over 18,000 doctors, respectively, in the United States.

The Company expects to continue to sell the CSV-1000 for the foreseeable future and add the CSV-2000 to these marketing efforts. The CSV-2000 is not
yet approved by the local organizations equivalent to the FDA in many countries, and this process can take up to one or more years. The CSV-1000 will
continue to be sold exclusively in those countries during that time period. The Company sold its first CSV-2000 in February of 2020 and sold two units for
the year ended December 31, 2020.

Proprietary Technology and Intellectual Property

Patents

The  Company  currently  owns  and  has  exclusive  rights  to  4  U.S.  patents  and  2  U.S.  patent  applications  and  3  foreign  patent  applications  covering  its
products and product candidates.

12

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Trade Secrets

The MapcatSF® device employs a proprietary algorithm for correcting macular pigment optical density measurements with respect to lens density effects.
More  particularly,  the  proprietary  algorithm  adjusts  the  photopic  luminosity  function  for  the  age  equivalence  of  the  subject’s  lens  using  a  relationship
disclosed by Sagawa and Takahashi (J. Opt. Soc. Am. 18, 2659-2667). The algorithm is embedded in an integrated circuit block designed in such a way as
to make it difficult to reverse engineer.

VectorVision’s  CSV-1000  has  proprietary  testing  charts  that  are  not  only  copyright  protected  but  can  only  be  reproduced  accurately  by  using  special
lithographs. These lithographs are kept secure, with very limited access, and are closely guarded trade secrets.

The AcQviz technology, the basis for vision test standardization for the CSV-2000 product line, is protected by two ITUS patents.

The formulations for Lumega-Z and GlaucoCetin have been submitted for US patent protection.

Trademarks

The Company utilizes trademarks on all current products and believes that having distinguishing marks is an important factor in marketing its products.
The Company has five U.S. registered trademarks on the principal register at the USPTO. These marks are listed below. The Company has three foreign
registered trademarks for its products and product candidates at this time and is evaluating whether additional foreign trademark protection is appropriate.
U.S. trademark registrations are generally for fixed, but renewable, terms. The Company also currently has common law trademark rights for the use of its
marks, including common law trademark rights to the NUTRIGUARD mark. Other trademarks include Lumega-Z, GlaucoCetin, VectorVision, CSV-1000
and CSV-2000.

Copyrights

In addition to patent and trademark protection, VectorVision has three copyrights registered with the U.S. Copyright Office relating to the CSV-1000 and
CSV-2000  medical  devices.  VectorVision  also  has  common  law  copyright  protection  on  the  testing  charts  contained  in  the  CSV-1000  and  CSV-2000
medical devices, which includes Vision Testing Chart #1, Vision Testing Chart #2 and Vision Testing Chart #3.

Products Manufacturing and Sources and Availability of Raw Materials

The Company outsources the manufacturing of its medical food products, nutraceutical product line and medical devices to contract manufacturers. The
Company processes orders through purchase orders and invoices with each manufacturer. The Company believes that there are multiple alternative sources,
suppliers and manufacturers available for its products in the event of a termination or a disagreement with any current vendor.

Government Regulation

Medical Foods

Under  the  Federal  Food,  Drug,  and  Cosmetic  Act  of  1938  (“FDCA”),  products  are  regulated  on  the  basis  of  their  intended  use.  Their  intended  use  is
determined by the objective factors surrounding their use. Numerous categories and subcategories of products exist under the FDCA that could relate to the
Company’s products, such as foods, food additives, dietary supplements, GRAS food components, new drugs, GRAS and Effective (“GRAS/E”) drugs for
over the counter use, and GRAS/E drugs for use under the supervision of a physician. The categories overlap and products can fall within more than one
category depending on their intended use.

The FDA is primarily responsible for regulating medical foods. A medical food is defined under the FDCA as a “food which is formulated to be consumed
or  administered  enterally  under  the  supervision  of  a  physician  and  which  is  intended  for  the  specific  dietary  management  of  a  disease  or  condition  for
which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.”

13

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The FDA advises that it considers the statutory definition of medical foods to “narrowly” constrain the types of products that fit within the category of
food.  FDA  regulations  further  describe  medical  foods  as  a  product  that:  (i)  is  a  specially  formulated  and  processed  product  (as  opposed  to  a  naturally
occurring  foodstuff  used  in  its  natural  state)  for  the  partial  or  exclusive  feeding  of  a  patient  by  means  of  oral  intake  or  enteral  feeding  by  tube;  (ii)  is
intended for the dietary management of a patient who, because of therapeutic or chronic medical needs, has limited or impaired capacity to ingest, digest,
absorb,  or  metabolize  ordinary  foodstuffs  or  certain  nutrients,  or  who  has  other  special  medically  determined  nutrient  requirements,  the  dietary
management  of  which  cannot  be  achieved  by  the  modification  of  the  normal  diet  alone;  (iii)  provides  nutritional  support  specifically  modified  for  the
management of the unique nutrient needs that result from the specific disease or condition, as determined by medical evaluation; (iv) is intended to be used
under medical supervision; and (v) is intended only for a patient receiving active and ongoing medical supervision wherein the patient requires medical
care on a recurring basis for, among other things, instructions on the use of the medical food.

Medical  foods  do  not  require  approval  or  review  by  FDA  prior  to  marketing.  FDA  does  not  require  pre-market  safety  or  efficacy  studies  (similar  to  or
comparable to Phase 2 & 3 trials for prescription drugs). However, a company must have data to demonstrate that the formula, when taken as directed,
meets the distinctive nutritional requirements of the particular disease or condition.

Like  any  evolving  area,  especially  where  no  premarket  approval  is  required,  the  FDA  reserves  the  right  to  raise  questions  about  the  qualification  of
products within any category. The Company and its Scientific Advisory Board examine the distinctive nutritional requirements of a disease.

The labeling for medical foods must comply with all applicable food labeling requirements, except for those specific requirements from which medical
foods are exempt. Medical foods are exempt, for example, from the labeling requirements for nutrient content claims and health claims under the Nutrition
Labeling and Education Act of 1990 (see 21 U.S.C. 343(r)(5)(A)). As with all food labels, printing must be legible, and many required elements must be
conspicuous, such as a statement of identity, which is the name of the food; the statement: “Must be administered under the supervision of a physician or
professional healthcare provider;” the quantity; the ingredients listing; the name and address of the distributor, among other requirements.

All ingredients in medical foods must be either generally recognized as safe (GRAS) or approved food-additives. Many ingredients have been determined
by the FDA to be GRAS and are listed as such by regulation. Other ingredients may achieve self-affirmed GRAS status through a panel of experts on that
particular substance that author a GRAS Report. The standard for an ingredient to achieve GRAS status requires not only technical demonstration of non-
toxicity and safety, but also general recognition and agreement on that safety by experts in the field. All ingredients used in the Company’s medical foods
are either FDA-approved food additives or have GRAS status. Because medical foods are typically taken with prescription drugs, the developer must assess
whether any medical food/drug interactions pose a risk.

Medical foods manufacturers must register with FDA pursuant to the Bioterrorism Act before producing foods. Manufacturers of foods also must follow
current Good Manufacturing Practice (“cGMP”) regulations. Entities that manufacture, package, label or hold food products must follow applicable cGMP
regulations. These regulations focus on practices that ensure sanitary and cleanly conditions of manufacturing facilities. The Company engages contract
manufacturers to manufactures its medical foods. .

The  Federal  Trade  Commission  has  primarily  responsibility  to  regulate  the  advertising  of  foods,  including  medical  foods.  Under  the  FTC  Act,  all
advertising claims, both express and implied, must be truthful, non-misleading, and substantiated.

Enforcement  by  the  regulators  is  post-market,  mostly  via  FDA  inspections  of  food  facilities,  including  packaging,  distribution  facilities,  and  fulfillment
houses, as well as the manufacturer. The FDA and FTC also gathers material at trade shows and conferences and examine websites.

14

 
 
 
 
 
 
 
 
 
 
Nutraceutical Regulation

The FDA regulates nutraceuticals as “dietary supplements” under the Dietary Supplement, Health and Education Act of 1994 (“DSHEA”) as a separate
regulatory category of food. Under DSHEA, a company is responsible for determining that the dietary supplements it manufactures or distributes are safe
and  that  any  representations  or  claims  made  about  them  are  substantiated  by  adequate  evidence  to  show  that  they  are  not  false  or  misleading.  Dietary
supplements  do  not  need  approval  from  FDA  before  they  are  marketed.  Except  in  the  case  of  a  “new  dietary  ingredient,”  where  pre-market  review  for
safety  data  and  other  information  is  required  by  law,  a  firm  does  not  have  to  provide  FDA  with  the  evidence  it  relies  on  to  substantiate  safety  or
effectiveness before or after marketing a product.

Dietary  supplement  manufacturers  must  register  with  FDA  pursuant  to  the  Bioterrorism  Act  before  producing  supplements.  Manufacturers  of  dietary
supplements  also  must  follow  current  Good  Manufacturing  Practice  (“cGMP”)  regulations.  Entities  that  manufacture,  package,  label  or  hold  dietary
supplement products must follow applicable cGMP regulations. These regulations focus on practices that ensure the identity, purity, quality, strength and
composition of dietary supplements.

Congress defined the term “dietary supplement” in DSHEA as “a product (other than tobacco) intended to supplement the diet that bears or contains one or
more  of  the  following  dietary  ingredients:  vitamins,  minerals,  amino  acids,  herbs  or  other  botanicals;  a  concentrate,  metabolite,  constituent,  extract  or
combination of the ingredients listed above.” A dietary supplement is a product taken by mouth that contains a “dietary ingredient” intended to supplement
the  diet.  The  “dietary  ingredients”  in  these  products  may  include  vitamins,  minerals,  herbs  or  other  botanicals,  amino  acids,  and  substances  such  as
enzymes,  organ  tissues,  glandulars,  and  metabolites  and  can  also  be  extracts  or  concentrates.  Dietary  supplements  are  produced  in  the  form  of  tablets,
capsules, softgels, gelcaps, liquids, or powders.

According to the FDA, a drug is an article intended to diagnose, cure, mitigate, treat or prevent disease. While nutraceuticals are not intended to cure or
treat  disease,  both  dietary  supplements  and  drugs  may  be  intended  to  affect  the  structure  or  function  of  the  body.  Dietary  supplements  that  contain
structure/function  claims  on  their  labels  must  bear  the  disclaimer:  “This  statement  has  not  been  evaluated  by  the  FDA.  This  product  is  not  intended  to
diagnose,  treat,  cure,  or  prevent  any  disease.”  The  manufacturer  is  responsible  for  ensuring  the  accuracy  and  truthfulness  of  these  claims;  they  are  not
approved by FDA. Moreover, dietary supplements are supposed to enhance the diet, not be used as a conventional food or as the sole item of a meal or diet,
and not supposed to be taken alone as a substitute for any food or medicine.

The DSHEA requires that a manufacturer or distributor notify FDA if it intends to market a dietary supplement in the U.S. that contains a “new dietary
ingredient.” A new dietary ingredient is an ingredient marketed after October 15, 1994. The manufacturer must demonstrate to FDA that the new ingredient
is reasonably expected to be safe for use in a dietary supplement. There is no authoritative list of dietary ingredients that were marketed before October 15,
1994. Therefore, manufacturers are responsible for determining if a dietary ingredient is “new.”

Under DSHEA, a company is responsible for determining that the dietary supplements it manufactures or distributes are safe and that any representations
or  claims  made  about  them  are  substantiated  by  adequate  evidence  to  show  that  they  are  not  false  or  misleading.  Dietary  supplements  must  meet  all
applicable regulations for food labeling. The DSHEA also requires certain disclaimers if structure/function or other health claims are made on the product
label.

Medical Device Regulatory Requirements

To fall within the purview of the FDA, a product must first meet the definition of a “device” under the FDCA.. Section 201(h) of the FDCA defines a
device  as  “an  instrument,  apparatus,  implement,  machine,  contrivance,  implant,  in  vitro  reagent,  or  other  similar  or  related  article,  including  any
component,  part,  or  accessory,  which  is  ...  intended  for  use  in  the  diagnosis  of  disease  or  other  conditions,  or  in  the  cure,  mitigation,  treatment,  or
prevention of disease, in man or other animals.”

FDA  categorizes  medical  devices  in  three  distinct  classes  based  on  the  potential  health  risks  to  the  public  –  Class  I,  Class  II,  and  Class  III.  Device
classifications are determined by the FDA based on the risk the medical device presents to the patient and the level of regulatory control required to ensure
the  safety  and  effectives  of  the  device.  Medical  devices  are  classified  as  Class  I,  II  or  III  based  upon  the  controls  necessary  to  provide  a  reasonable
assurance  of  the  safety  and  effectiveness  of  the  device,  and  factors  relevant  to  this  determination  include  the  device’s  intended  use,  technological
characteristics, and the risk to patients if the device were to fail. Class I devices, which are subject only to general controls, generally represent the lowest-
risk category of devices, while Class III devices, which are subject to general controls and premarket approval, generally represent the highest-risk devices.
Class II devices typically require premarket notification to FDA and clearance under Section 510(k) of the FDCA prior to marketing (unless an exemption
applies).

15

 
 
 
 
 
 
 
 
 
 
 
 
The FDA also regulates the labeling and manufacturing of medical devices. Medical device manufacturers must register the facilities and list their devices
with  the  FDA.  Manufacturers  are  subject  the  current  good  manufacturing  practice  (cGMP)  regulations,  which  govern  activities  such  as  the  design,
processing, testing, packaging, distribution, and storage of devices. Manufacturers are subject to periodic inspection by the FDA.

While the FDA governs the labels and labeling of medical devices, the FTC governs the advertising of most devices. Under the FTC Act, all advertising
claims, both express and implied, must be truthful, non-misleading, and substantiated.

The Company is registered with the FDA as a medical device manufacturer under registration number 3010367547. The MapcatSF is listed with the FDA
as  a  Class  I  medical  device.  With  the  assistance  of  regulatory  affairs  consultants,  the  Company  has  determined  the  applicable  product  code  for  the
MapcatSF is HJW and the applicable Code of Federal Regulation is 886.1050. The FDA has determined that this particular predicate device, and related
product code, is a Class I medical device. Based on this, the Company believes the MapcatSF is correctly classified as a Class I medical device and does
not require any premarket approval.

VectorVision is registered with the FDA as a medical device manufacturer under registration number 1527853. The CSV-1000, CSV-2000 and the ESV-
3000 medical devices are listed with the FDA as Class I medical devices. The applicable product code for these devices is HOX and the applicable Code of
Federal Regulation is 886.1150. As Class I medical devices, the CSV-1000, CSV-2000 and the ESV-3000 devices do not require premarket approval.

Stark Law

Congress enacted significant prohibitions against physician self-referrals in the Omnibus Budget Reconciliation Act of 1993. This law and its supporting
regulations, which have been amended and expanded substantially, are commonly referred to as the “Stark Law,” and prohibit a physician from making any
referral  of  a  Stark  Designated  Health  Service  (“DHS”)  to  an  entity  with  which  the  physician  has  any  kind  of  financial  relationship,  unless  all  of  the
requirements of a statutory or regulatory exception are met. Stark covered DHS include both outpatient prescription drugs and diagnostic testing that are
reimbursable by Medicare or Medicaid. Many states have similar laws, some of which can apply to all payors and not just governmental payors. While the
Company believes that its arrangements with its customers are in compliance with the federal and any state Stark Laws, the Stark Laws present different
levels of risks as to the Company’s two lines of business: (1) sale of the Company’s medical food, Lumega-Z, and medical device, the MapcatSF; and (2)
the Company’s performance of TCD testing.

These products are neither prescription drugs nor are they reimbursable under any federal program at present. The federal Stark Law is thus inapplicable.
Further,  the  Company’s  believes  that  these  products  are  also  not  covered  under  any  potentially  applicable  state  Stark  Laws.  The  federal  Stark  Law,
however,  includes  an  exception  for  the  provision  of  in-office  ancillary  services,  including  a  physician’s  dispensing  of  outpatient  prescription  drugs,
provided that the physician meets specified requirements. To the extent that the products might become reimbursable under a federal program, or otherwise
become covered under the Stark Law, the Company believes that the physicians who use the Company’s medical device, the MapcatSF, purchase the CSV-
1000, CSV-2000 or ESV-3000, or recommend its medical foods, Lumega-Z and GlaucoCetin, to their patients are aware of these requirements. However,
the Company does not monitor their compliance and has no assurance that the physicians are in material compliance with Stark II. If it were determined
that the physicians who use the Company’s medical device or prescribe medical foods purchased from the Company were not in compliance with Stark II,
it could potentially have an adverse effect on the Company’s business, financial condition and results of operations.

16

 
 
 
 
 
 
 
 
 
Anti-Kickback Statute and HIPAA Criminal Laws

The federal anti-kickback statute (the “AKS”) applies to Medicare, Medicaid and other state and federal programs. AKS prohibits the solicitation, offer,
payment or receipt of remuneration in return for referrals or the purchase, or in return for recommending or arranging for the referral or purchase, of goods,
including drugs, covered by the federal health care programs. At present, the Company does not participate in any federal programs and its products are not
reimbursed by Medicare, Medicaid or any other state or federal program. The AKS is a criminal statute with criminal penalties, as well as potential civil
and  administrative  penalties.  The  AKS,  however,  provides  a  number  of  statutory  exceptions  and  regulatory  “safe  harbors”  for  particular  types  of
transactions.  Many  states  have  similar  fraud  and  abuse  laws  and  their  own  anti-kickback  laws,  some  of  which  can  apply  to  all  payors,  and  not  just
governmental payors. While the Company believes that it is in material compliance with both federal and state AKS laws, the AKS laws present different
levels of risks as to the Company’s two lines of business: (1) sale of the Company’s medical foods, Lumega-Z and GlaucoCetin, and medical device, the
MapcatSF; and (2) the Company’s performance of TCD testing.

At present, the Company’s products are not reimbursable under any federal program. If, however, that changes in the future and it were determined that the
Company was not in compliance with the AKS, the Company could be subject to liability, and its operations could be curtailed. Moreover, if the activities
of its customers or other entity with which the Company has a business relationship were found to constitute a violation of the AKS and the Company, as a
result of the provision of products or services to such customer or entity, were found to have knowingly participated in such activities, the Company could
be subject to sanctions or liability under such laws, including civil and/or criminal penalties, as well as exclusion from government health programs. As a
result  of  exclusion  from  government  health  programs,  neither  products  nor  services  could  be  provided  to  any  beneficiaries  of  any  federal  healthcare
program.

HIPAA Compliance and Privacy Protection

HIPAA  established  comprehensive  federal  protection  for  the  privacy  and  security  of  health  information.  The  HIPAA  standards  apply  to  three  types  of
organizations,  or  “Covered  Entities”:  (1)  health  plans,  (2)  health  care  clearing  houses,  and  (3)  health  care  providers  who  conduct  certain  health  care
transactions electronically. Covered Entities must have in place administrative, physical and technical standards to guard against the misuse of individually
identifiable health information. Additionally, some state laws impose privacy protections more stringent than HIPAA’s. There are also international privacy
laws, such as the European Data Directive, that impose restrictions on the access, use, and disclosure of health information. All of these laws may impact
the Company’s business in the future.

HITECH Act

The Health Information Technology for Economic and Clinical Health (“HITECH”) Act promotes the adoption and meaningful use of health information
technology.  The  HITECH  Act  addresses  the  privacy  and  security  concerns  associated  with  the  electronic  transmission  of  health  information,  in  part,
through several provisions that strengthen the civil and criminal enforcement of the HIPAA rules.

Physician Sunshine Act

Health Care Reform Law provision, generally referred to as the Physician Payment Sunshine Act or Open Payments Program, has imposed new reporting
and disclosure requirements for drug and device manufacturers with regard to payments or other transfers of value made to certain practitioners (including
physicians, dentists and teaching hospitals), and for such manufacturers and for group purchasing organizations, with regard to certain ownership interests
held by physicians in the reporting entity. The Centers for Medicine and Medicaid Services (“CMS”) publishes information from these reports on a publicly
available website, including amounts transferred and physician, dentist and teaching hospital identities.

Under  the  Physician  Payment  Sunshine  Act  applicable  organizations  are  required  to  collect  and  report  detailed  information  regarding  certain  financial
relationships  they  have  with  physicians,  dentists  and  teaching  hospitals.  The  Physician  Payment  Sunshine  Act  preempts  similar  state  reporting  laws,
although some companies may also be required to report under certain state transparency laws that address circumstances not covered by the Physician
Payment Sunshine Act, and some of these state laws, as well as the federal law, are ambiguous. Because the Company’s medical devices are Class I, not
subject to premarket approval, and not reimbursable under Medicare, Medicaid, or the Children’s Health Insurance Program the Company believes it is not
currently  subject  to  the  Physician  Payment  Sunshine  Act  requirements.  As  the  Company  pursues  commercialization  of  its  medical  devices,  these
requirements will be reevaluated to determine their applicability to the Company’s activities.

17

 
 
 
 
 
 
 
 
 
 
 
 
The Federal False Claims Act

The Federal False Claims Act provides for the imposition of extensive financial penalties (including treble damages and fines of over $22,000 for every
false claim) if a provider submits false claims to any governmental health program either knowingly or in reckless disregard or in deliberate ignorance of
the truth or falsity of the claims at issue. Liability under the False Claims Act can arise from patterns of deficient documentation, coding and billing, as well
as for billing for services that are deemed not to have been medically necessary for the treatment of the patient. Many states have their own False Claims
Acts as well. The Company was billing governmental health care programs for the TCD testing, and the False Claims Act is thus potentially applicable to
the  Company’s  operations.  The  Company  put  in  place  a  fraud  and  abuse  compliance  program  that  was  designed  to  ensure  that  the  Company’s
documentation, coding and billing for TCD tests were accurate and compliant. Any patterns of uncorrected deficiencies in documenting, coding and billing
for TCD tests, however, may result in fines and other liabilities, which may adversely affect the Company’s results of operations.

State Regulatory Requirements

Each state has its own regulations concerning physician dispensing, restrictions on the Corporate Practice of Medicine (“CPOM”), anti-kickback and false
claim regulations. In addition, each state has a board of pharmacy that regulates the sale and distribution of drugs and other therapeutic agents. Some states
require that a physician obtain a license to dispense prescription products. When considering the commencement of business in a new state, the Company
consults with healthcare counsel regarding the expansion of operations and utilizes local counsel when necessary.

Many states prohibit or otherwise regulate under CPOM rules the extent to which non-licensed personnel may be involved in the practice of medicine or
otherwise employ licensed personnel. Related state rules further limit the extent to which fees for professional services may be shared or “split” between
parties. Under the TCD Testing line of business, such rules in some states my impact the Company’s relationship with the radiologists who will be reading
and interpreting the results of the TCD tests, and thereby providing the “professional component” of such tests. The Company is structuring its financial
and billing relationships with such radiologists to be in compliance with applicable state rules. Failure to comply with state CPOM and fee splitting rules,
however, may result in fines and other liabilities, which may adversely affect the Company’s results of operations.

Other United States Regulatory Requirements

In  the  United  States,  the  research,  manufacturing,  distribution,  sale,  and  promotion  of  food  and  medical  devices  products  are  subject  to  regulation  by
various federal, state, and local authorities in addition to the FDA, including the Centers for Medicare and Medicaid Services (formerly the Health Care
Financing  Administration),  other  divisions  of  the  United  States  Department  of  Health  and  Human  Services  (e.g.,  the  Office  of  Inspector  General),  the
United  States  Department  of  Justice  and  individual  United  States Attorney  offices  within  the  Department  of  Justice,  and  state  and  local  governments.
Pricing  and  rebate  programs  must  comply  with  the  Medicaid  rebate  requirements  of  the  Omnibus  Budget  Reconciliation  Act  of  1990  and  the  Veterans
Health  Care  Act  of  1992,  each  as  amended.  If  products  are  made  available  to  authorized  users  of  the  Federal  Supply  Schedule  of  the  General  Services
Administration, additional laws and requirements apply. All of these activities are also potentially subject to federal and state consumer protection, unfair
competition, and other laws. In addition, the Company may be subject to federal and state laws requiring the disclosure of financial arrangements with
health care professionals.

Foreign Regulatory Requirements

The Company may eventually be subject to widely varying foreign regulations, which may be quite different from those of the FDA, governing clinical
trials, product design, manufacturing, labeling, product registration and approval, and sales. Whether or not FDA approval has been obtained, generally the
Company  must  obtain  separate  authorization  for  a  product  by  the  comparable  regulatory  authorities  of  foreign  countries  prior  to  the  commencement  of
product  marketing  in  those  countries.  In  certain  countries,  regulatory  authorities  also  establish  pricing  and  reimbursement  criteria.  The  authorization  or
approval process varies from country to country.

18

 
 
 
 
 
 
 
 
 
 
 
Corporate History

Guardion Health Sciences, Inc. was formed under the name P4L Health Sciences, LLC in December 2009 in California as a limited liability company. The
Company changed its name to Guardion Health Sciences, LLC in December 2009. In June 2015, the Company converted into a Delaware “C” corporation.

Reverse Stock Split

On March 1, 2021, the Company filed a Certificate of Amendment to its Certificate of Incorporation, as amended, with the Secretary of State of the State of
Delaware  to  effectuate  a  one-for-six  (1:6)  reverse  stock  split  (the  “Reverse  Stock  Split”)  of  its  common  stock  without  any  change  to  its  par  value.
Proportional adjustments for the Reverse Stock Split were made to the Company’s outstanding common stock, stock options, and warrants as if the split
occurred at the beginning of the earliest period presented in this Annual Report.

Employees and Human Capital Resources

As of March 25, 2021, we had 13 full-time employees, including 12 full-time employees and one part-time employee. We consider our relationship with
our employees to be good. Our future performance depends significantly upon the continued service of our key personnel and our ability to attract highly
skilled employees. We provide our employees with opportunities for equity ownership.

Advisory Boards

The  Company’s  research  and  development  efforts  are  assisted  by  a  Science  Advisory  Board  with  advice  from  a  Medical  Advisory  Board  consisting  of
practicing physicians. Both teams are committed to revealing and validating the connections between health and nutrition and then developing products
based on these findings. Their joint goal is the integration of a medical model incorporating nutritional therapy into clinical practice.

Science Advisory Board

The Company’s Science Advisory Board is a product development and research team of esteemed experts in the fields of biochemistry, biophysics, and
clinical nutrition. In addition to developing products based on scientific studies in the public domain, members of the Science Advisory Board conduct and
publish their own evidence. Their expertise and the evidence they develop guide the formulation of the Company’s products. As an elite team of scientists
and researchers, members of the Science Advisory Board contribute a high level of experience and judgment to the field of retinal health and nutrition. The
Science Advisory Board currently consists of:

● Richard A. Bone, BSc, PhD, FARVO

Dr. Bone is an experimental biophysicist and professor in the department of physics at Florida International University in Miami. Bone was just
awarded The Presidential Award for achievement in macular pigment research and dedicated service to the carotenoid field.

● John T. Landrum, BS, MS, PhD, FARVO

Dr. Landrum is a research scientist and professor of Chemistry and Biochemistry at Florida International University (FIU). Dr. Landrum was just
appointed president of the International Carotenoid Society for the next 3 years.

● William E. Sponsel, M.D., M.B., Ch.B., F.R.A.N.Z.C.O., F.A.C.S.

Dr. Sponsel established the Glaucoma Research and Diagnostic Laboratory at Indiana University in 1991, and was later recruited to the University
of Texas Health Science Center at San Antonio in 1994, where he became Professor and Director of Clinical Research. He is presently Professor
of Vision Sciences at UIW and Adjunct Professor of Biomedical Engineering at UTSA in San Antonio, Texas.

● Robert J. Donati, PhD.

Dr. Donati has a PhD in Anatomy and Cell Biology with a minor in Neuroscience from the University of Illinois at Chicago (UIC). He joined the
faculty at the Illinois College of Optometry (ICO) in 2004 and has been an Associate Professor for the past 5 years. He is currently the Chair of the
ICO Institutional Review Board.

19

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
● Mark F. McCarty

Mr. McCarty  is  a  nutritionist  and  a  researcher  who  obtained  his  undergraduate  education  in  biochemistry  at  the  University  of  California  San
Diego, Revelle College. He has published over three hundred articles on a wide range of biomedical topics in the peer-reviewed medical literature.
He has been awarded seven U.S. patents for a variety of applied nutritional measures. McCarty co-founded NutriGuard Research and previously
worked as the research director for Nutrition 21. Mr. McCarty also serves as the Director of Research of NutriGuard Formulations, Inc.

● In memoriam of:

Sheldon Saul Hendler, M.D., Ph.D., FACP, FACN, FAIC – (1936-2012)
Dr. Hendler was the principal author and editor of the PDR for Nutritional Supplements. Dr. Hendler passed away suddenly in November 2012.
He was the founding head of the Company’s Science Advisory Board. Dr. Hendler supervised and completed the formulas for Lumega-Z for the
Company in 2011.

Medical Advisory Board

The Company’s Medical Advisory Board is composed of clinicians who are active medical practitioners. Members of the Medical Advisory Board consult
with  the  Scientific  Advisory  Board  and  management  on  the  current  standards  of  care  in  relevant  medical  practices.  Members  of  the  Medical  Advisory
Board objectively advise on trends, needs, and issues of concern within their specialties. Their input helps shape the direction of the Company’s research
and product development efforts. The Medical Advisory Board currently consists of:

● Robert Ritch, M.D.

Dr. Ritch holds the Shelley and Steven Einhorn Distinguished Chair in Ophthalmology and is Surgeon Director Emeritus and Chief of Glaucoma
Services at the New York Eye & Ear Infirmary, New York City and Professor of Ophthalmology at The New York Medical College, Valhalla, New
York.

● John A. Hovanesian, M.D., FACS

Dr. Hovanesian  is  faculty  member  at  the  UCLA  Jules  Stein  Eye  Institute,  a  board-certified  ophthalmologist,  and  an  internationally  recognized
leader  in  the  field  of  corneal,  cataract,  refractive,  and  laser  surgery.  He  is  the  chairman  of  the  American  Academy of Ophthalmology’s online
cataract surgery education committee and an editorial board member for five other eye journals.

● Richard Rosen, M.D.

Dr. Rosen is a vitreoretinal surgeon and consultant at the New York Eye and Ear Infirmary where he serves as Vice Chairman and  Director  of
Ophthalmology Research, as well as Surgeon Director and Chief of Retinal Services. Dr. Rosen is Professor of Ophthalmology at the Icahn School
of Medicine at Mount Sinai and Visiting Professor in Applied Optics at the University of Kent in Canterbury, UK.

● William Trattler, M.D.

Dr. Trattler  received  the  “Outstanding  Young  Ophthalmologist  Leadership  Award”  from  the  Florida  Society  of  Ophthalmology  (FSO)  and  was
elected President of the Miami Ophthalmology Society for 2006. In March 2006, Dr. Trattler was selected as one of the top 50 opinion leaders in
Ophthalmology, as voted by his peers in a National survey.

● James A. Davies, M.D.

Dr. Davies is a Fellow of the American College of Surgeons, the American Academy of Ophthalmology and the American Society of Cataract and
Refractive Surgery. He serves on the Medical Advisory Board of Bausch + Lomb Surgical, Inc., and is a consultant for Glaukos, Inc., Optovue,
Inc., and Guardion Health Sciences. He also serves as an advisor to the Charity Vision Foundation.

● P. Dee Stephenson, M.D.

Dr.  Stephenson  is  a  Board  Certified  Ophthalmic  Surgeon  with  extensive  expertise  in  micro-incisional  cataract  surgery  and  implantation  of
premium intra-ocular lenses, as well as custom femto cataract techniques. Dr. Stephenson has been recognized by numerous institutions for her
expertise. She is also the current president (2015-2017) of the American College of Eye Surgeons (ACES).

20

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
● Bridgitte Shen Lee, O.D.

Dr. Lee  is  the  cofounder  of  Vision  Optique.  She  also  founded  iTravelCE  in  2010  and  serves  as  a  consultant  and  a  speaker  for  various optical
industry companies to introduce eye care professionals in the U.S. and Asia to the latest innovations. She served on the Houston Miller Theatre
Advisory Board, and she currently serves on the Houston Ballet Foundation Board of Trustees.

● Joseph S. Andrews, M.D.

Dr. Andrews  is  a  member  of  the  Private  Internal  Medicine  Center  (PIMC)  at  Scripps  Clinic  Torrey  Pines,  San  Diego  and  has  diplomate  board
certification from the American Board of Internal Medicine. He is currently a clinical mentor at St. Vincent de Paul Clinic. In 2009, he was listed
among San Diego’s Top Doctors by San Diego magazine.

● John E. Wanebo, M.D., FACS

Dr. Wanebo is the Director of Neurotrauma at the Scottsdale Healthcare System. Additionally, he serves as a staff neurosurgeon and Director of
the Moyamoya Center at Barrow Neurological Institute, St. Joseph’s Medical Center, in Phoenix, where he is also an assistant professor within the
Division of Neurological Surgery. He is board certified by the American Board of Neurological Surgery.

RISK FACTORS SUMMARY

Our business is subject to significant risks and uncertainties that make an investment in us speculative and risky. Below we summarize what we
believe are the principal risk factors, but these risks are not the only ones we face, and you should carefully review and consider the full discussion of our
risk  factors  in  the  section  titled  “Risk  Factors”,  together  with  the  other  information  in  this  Annual  Report  on  Form  10-K.  If  any  of  the  following  risks
actually  occurs  (or  if  any  of  those  listed  elsewhere  in  this  Annual  Report  on  Form  10-K  occur),  our  business,  reputation,  financial  condition,  results  of
operations, revenue, and future prospects could be seriously harmed. Additional risks and uncertainties that we are unaware of, or that we currently believe
are not material, may also become important factors that adversely affect our business.

●  The Company’s future success is largely dependent on the successful commercialization of Lumega-Z® and GlaucoCetinTM medical foods, its line of

nutraceuticals, the MapcatSF® medical device, and the CSV-1000 and CSV-2000 medical devices.

●  The COVID-19 global pandemic could adversely impact our business, including the commercialization of our medicines, our supply chain, our clinical

trials, our liquidity and access to capital markets and our business development activities.

●  The Company has limited experience in developing medical foods, medical devices and nutraceuticals and it may be unable to commercialize some of

the products and services it develops or acquires.

●  Our stock price has fluctuated significantly in the past, has recently been volatile and may be volatile in the future, and as a result, investors in our

common stock could incur substantial losses.

●  Additional risks and uncertainties include:

●  Our ability to integrate a new management team;

●  Our ability to comply with the continued listing requirements of the Nasdaq Capital Market;

●  Our ability to successfully pursue our business plan and execute our strategy, design and implement systems and programs to develop products and

deliver to market on a timely basis; and

21

 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
  
  
  
  
  
  
 
●  The effect of economic and political conditions in the United States or other nations that could impact our ability to sell our products and services or

gain customers.

ITEM 1A. RISK FACTORS

Investing in the Company’s common stock involves a high degree of risk. Prospective investors should carefully consider the risks described below, together
with all of the other information included or referred to in this Form 10-K, before purchasing shares of the Company’s common stock. There are numerous
and varied risks that may prevent the Company from achieving its goals. If any of these risks actually occurs, the business, financial condition or results of
operations  may  be  materially  adversely  affected.  In  such  case,  the  trading  price  of  the  Company’s  common  stock  could  decline  and  investors  in  the
Company’s common stock could lose all or part of their investment.

Risks Related to the Company’s Business

As the Company has incurred recurring losses and negative cash flows since our inception, there is no assurance that the Company will be able to
reach and sustain profitability. If it cannot, the Company will be required to secure additional financing, which the Company may not be able to obtain
on favorable terms or at all.

The  Company  has  incurred  net  losses  since  inception  in  2009  and  cannot  be  certain  if  or  when  the  Company  will  produce  sufficient  revenue  from
operations to support costs. The Company had a net loss of $8,571,657 for the year ended December 31, 2020 and a net loss of $10,878,308 for the year
ended December 31, 2019. The Company had an accumulated deficit of $54,083,328 as of December 31, 2020. The Company expects to continue to incur
net losses and negative operating cash flows in the near-term. At December 31, 2020, the Company had cash on hand of $8,518,732 and working capital of
$8,021,152. Subsequent to December 31, 2020, the Company sold an aggregate of 7,566,733 shares of its common stock for net proceeds of approximately
$33,600,000  in  two  offerings,  one  completed  in  January  2021,  and  one  completed  in  February  2021.  In  addition,  in  January  and  February  2021,  the
Company  issued  an  aggregate  of  1,647,691  shares  of  common  stock  upon  the  exercise  of  warrants  and  received  cash  proceeds  of  $3,608,509.
Notwithstanding  the  net  loss  for  2020,  management  believes  that  its  current  cash  balance,  plus  the  net  proceeds  from  issuance  of  common  stock  and
exercise  of  warrants  in  January  and  February  2021,  is  sufficient  to  fund  operations  for  at  least  one  year  from  the  date  the  Company’s  2020  financial
statements are issued.

The Company will continue to incur significant expenses related to commercialization of its products and with respect to efforts to build its infrastructure,
expand its operations, and execute on its business plans. The Company may also utilize cash to fund acquisitions.

Even if profitability is achieved in the future, the Company may not be able to sustain profitability on a consistent basis. The Company expects to continue
to incur substantial losses and negative cash flow from operations for the foreseeable future.

The Company does not have any credit facilities as a source of present or future funds, and there can be no assurance that the Company will be able to raise
sufficient additional capital on acceptable terms, or at all. The Company may seek additional capital through a combination of private and public equity
offerings  and  debt  financings.  If  the  Company  raises  additional  funds  through  the  issuance  of  equity  or  convertible  debt  securities,  the  percentage
ownership of our stockholders could be significantly diluted, and these newly issued securities may have rights, preferences or privileges senior to those of
existing stockholders. Debt financing, if obtained, may involve agreements that include covenants limiting or restricting the ability to take specific actions,
such as incurring additional debt, would increase expenses and require that Company assets secure such debt. Moreover, any debt the Company incurs must
be repaid regardless of our operating results.

The  Company’s  ability  to  obtain  additional  financing  in  the  future  will  be  subject  to  a  number  of  factors,  including  market  conditions,  operating
performance and investor sentiment. If the Company is unable to raise additional capital when required or on acceptable terms, the Company may have to
significantly delay, scale back or discontinue our operations or obtain funds by entering into agreements on unattractive terms, which would likely have a
material adverse effect on its business, stock price and relationships with third parties, at least until additional funding is obtained. If the Company does not
have sufficient funds to continue operations, the Company could be required to seek other alternatives that would likely result in our stockholders losing
some or all of their investment.

22

 
 
 
 
 
 
 
 
 
 
 
 
The Company’s future success is largely dependent on the successful commercialization of Lumega-Z® and GlaucoCetinTM medical foods, its line of
nutraceuticals, the MapcatSF® medical device, and the CSV-1000 and CSV-2000 medical devices.

The future success of the Company’s business is largely dependent upon the successful commercialization of its medical foods, nutraceuticals and medical
devices. If the Company is unable to establish and maintain adequate sales, marketing and distribution capabilities or enter into or maintain agreements
with third parties to do so, it may be unable to successfully commercialize its products. Establishing and maintaining sales, marketing, and distribution
capabilities are expensive and time-consuming. Such expenses may be disproportionate compared to the revenues the Company may be able to generate
from sales. If this occurs, it will have an adverse impact on operations and the Company’s ability to fund future development and commercialization efforts.

The COVID-19 global pandemic could adversely impact our business, including the commercialization of our medicines, our supply chain, our clinical
trials, our liquidity and access to capital markets and our business development activities.

On March 11, 2020, the World Health Organization made the assessment that a novel strain of coronavirus, which causes the COVID-19 disease, can be
characterized  as  a  pandemic.  The  President  of  the  United  States  declared  the  COVID-19  pandemic  a  national  emergency  and  many  states  and
municipalities in the Unites States have announced aggressive actions to reduce the spread of the disease, including limiting non-essential gatherings of
people, ceasing all non-essential travel, ordering certain businesses and government agencies to cease non-essential operations at physical locations and
issuing “shelter-in-place” orders which direct individuals to shelter at their places of residence (subject to limited exceptions). The effects of government
actions and our policies and those of third parties to reduce the spread of COVID-19 may negatively impact productivity and our ability to market and sell
our products, cause disruptions to our supply chain and impair our ability to execute our business development strategy. These and other disruptions in our
operations and the global economy could negatively impact our business, operating results and financial condition.

The commercialization of our products may be adversely impacted by COVID-19 and actions taken to slow its spread. For example, patients may postpone
visits to healthcare provider facilities, certain healthcare providers have temporarily closed their offices or are restricting patient visits, healthcare provider
employees may become generally unavailable and there could be disruptions in the operations of payors, distributors, logistics providers and other third
parties that are necessary for our products to be recommended and administered to patients.

Quarantines, shelter-in-place and similar government orders, or the perception that such orders, shutdowns or other restrictions on the conduct of business
operations could occur, related to COVID-19 or other infectious diseases could impact personnel at third-party manufacturing facilities upon which we rely,
or the availability or cost of materials, which could disrupt the supply chain for our products.

The spread of COVID-19 and actions taken to reduce its spread may also materially affect us economically. As a result of the COVID-19 pandemic and
actions taken to slow its spread, the global credit and financial markets have recently experienced extreme volatility and disruptions, including diminished
liquidity  and  credit  availability,  declines  in  consumer  confidence,  declines  in  economic  growth,  increases  in  unemployment  rates  and  uncertainty  about
economic stability. If the equity and credit markets continue to deteriorate, it may make any additional debt or equity financing more difficult, more costly
or more dilutive. While the potential economic impact brought by, and the duration of, COVID-19 may be difficult to assess or predict, there could be a
significant  disruption  of  global  financial  markets,  reducing  our  ability  to  access  capital,  which  could  in  the  future  negatively  affect  our  liquidity  and
financial position or our business development activities.

COVID-19 continues to rapidly evolve. The extent to which COVID-19 may impact the commercialization of our products, our supply chain, our access to
capital and our business development activities, will depend on future developments, which are highly uncertain and cannot be predicted with confidence,
such as the ultimate geographic spread of the pandemic, the duration of the pandemic and the efforts by governments and business to contain it, business
closures or business disruptions and the impact on the economy and capital markets.

23

 
 
 
 
 
 
 
 
 
 
The Company has limited experience in developing medical foods, medical devices and nutraceuticals and it may be unable to commercialize some of
the products and services it develops or acquires.

Development  and  commercialization  of  medical  foods,  nutraceuticals,  and  medical  devices  involves  a  lengthy  and  complex  process.  The  Company  has
limited  experience  in  developing  products  and  has  only  two  commercialized  medical  food  products  on  the  market,  Lumega-Z  and  GlaucoCetin.  The
Company cannot assure you that it is possible to successfully commercialize the MapcatSF. The Company launched the CSV-2000 in Q1 2020, but there is
no assurance the introduction of the instrument will be successful. Furthermore, there is no guarantee that the NutriGuard nutraceuticals will be marketable
or that the Company will achieve commercial success with the product line.

Even  if  the  Company  develops  or  acquires  products  for  commercial  use,  these  products  may  not  be  accepted  by  the  medical  and  pharmaceutical
marketplaces or be capable of being offered at prices that will enable the Company to become profitable. The Company cannot assure you that its products
will be approved by regulatory authorities, if required, or ultimately prove to be useful for commercial markets, meet applicable regulatory standards, or be
successfully marketed.

The Company’s ongoing investment in new businesses and new products, services, and technologies is inherently risky, and could disrupt its current
operations.

The Company has invested and expects to continue to invest in new businesses, products, services, and technologies. Such endeavors involve significant
risks and uncertainties, including insufficient revenues from such investments to offset any new liabilities assumed and expenses associated with these new
investments, inadequate return of capital on the Company’s investments, distraction of management from current operations, and unidentified issues not
discovered in its due diligence of such strategies and offerings that could cause the Company to fail to realize the anticipated benefits of such investments
and incur unanticipated liabilities. Because these new ventures are inherently risky, no assurance can be given that such strategies and offerings will be
successful and will not adversely affect the Company’s reputation, financial condition, and operating results.

The Company and its suppliers and manufacturers are subject to a number of existing laws, regulations and industry initiatives and the regulatory
environment  of  the  healthcare  industry  is  continuing  to  change.  If  it  is  determined  that  the  Company  or  its  suppliers  or  manufacturers  are  not  in
compliance with the laws and regulations to which they are respectively subject, the Company’s business, financial condition and results of operations
may be adversely affected.

As a participant in the healthcare industry, the Company’s operations and relationships, and those of the Company’s customers, are regulated by a number
of  federal,  state,  local,  and  foreign  governmental  entities  with  oversight  of  various  aspects  of  product  manufacture,  distribution,  sale,  and  use.  The
regulations are very complex, have become more stringent over time, and are subject to changing and varying interpretations. Regulatory restrictions or
changes could limit our ability to carry on or expand our operations or result in higher than anticipated costs or lower than anticipated sales. The FDA and
other federal and state governmental agencies regulate numerous elements of our business, including:

● Product design and development;

● pre-clinical and clinical testing;

● labeling, and storage;

● establishment registration and product listing;

● product safety, including product recalls or other field-safety actions;

● marketing, manufacturing, sales, and distribution;

24

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
● premarket clearance or approval;

● record keeping procedures;

● advertising and promotion;

● post-market surveillance, including reporting of adverse events; and

● product import and export.

We may be subject to similar foreign laws that govern all of the above elements of our business, including pre-market and post marketing obligations for
our medical foods and nutraceuticals. The time required to obtain authorization to sell our products in foreign countries may be longer or shorter than that
required by the FDA, and requirements for licensing a product in a foreign country may differ significantly from FDA requirements. In the European Union
(EU),  member  states  are  responsible  for  enforcing  the  EU’s  rules  and  for  ensuring  that  only  compliant  products  are  placed  on  the  market  in  their
jurisdictions. Member states have powers to suspend the marketing and use, or demand the recall, of unsafe or non-compliant medical products. They also
have the power to bring enforcement action against companies or individuals for breaches of the rules governing certain medical products.

The FDA, states, and other regulatory authorities have broad enforcement powers. Failure to comply with applicable regulatory requirements could result
in enforcement action by the FDA, state, or regulatory authorities, which may include the following:

● untitled letters or warning letters;

● fines, disgorgement, restitution, or civil penalties;

● injunctions (e.g., total or partial suspension of production) or consent decrees;

● product recalls, administrative detention, or seizure;

● customer notifications or repair, replacement, or refunds;

● operating restrictions or partial suspension or total shutdown of production;

● delays in or refusal to grant requests for future product approvals, new intended uses, or modifications to existing products; and

● criminal prosecution.

Any of these sanctions could result in higher than anticipated costs or lower than anticipated sales and have a material adverse effect on our reputation,
business, financial condition, and results of operations.

Foods and nutraceuticals do not require premarket approval by FDA before they may be distributed in the United States (with limited exceptions). Unless
an exemption applies, medical devices distributed in the United States must receive either premarket clearance under Section 510(k) of the FDCA, grant of
a  de  novo  classification  request,  or  premarket  approval  of  a  premarket  application  before  they  may  be  commercially  distributed.  Medical  devices  are
classified into one of three classes - Class I, Class II, or Class III - depending on the degree of risk associated with the device and the extent of control
needed  to  ensure  safety  and  effectiveness.  Medical  devices  deemed  to  pose  relatively  low  risk  are  placed  in  Class  I,  which  generally  do  not  require
premarket notification or premarket approval.

In the US, the FDA and Federal Trade Commission (FTC) largely govern the promotion of food, supplements, and medical devices, and the Company’s
products must be promoted in compliance with the laws and regulations of these and other regulators. FDA defines a “drug” as an article that is intended
for  use  in  the  cure,  treatment,  prevention  or  mitigation  of  a  disease.  A  medical  food  is  defined  as  “a  food  which  is  formulated  to  be  consumed  or
administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which
distinctive  nutritional  requirements,  based  on  recognized  scientific  principles,  are  established  by  medical  evaluation.”  While  the  Company  believes
Lumega-Z and GlaucoCetin are medical foods, if the FDA determines Lumega-Z or GlaucoCetin to be a drug, the Company and the product would be
subject to considerable additional FDA regulation.

25

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The Company believes the MapcatSF is classified as a Class I medical device that does not require premarket approval. The Company also believes the
CSV-2000 is a Class I medical device that does not require premarket approval. If, however, the FDA were to determine that the MapcatSF or CSV-2000 is
a Class II medical device, the products would be subject to additional regulatory requirements, including premarket approval.

The NutriGuard line of products are nutraceuticals and are regulated as dietary supplements under the Dietary Supplement, Health and Education Act of
1994 (“DSHEA”). DSHEA places dietary supplements in a special regulatory category under the general umbrella of “foods,” with differing requirements
from consumer food products and medical foods. Dietary supplements are supposed to enhance the diet and not be represented as a conventional food or as
the sole item of a meal or diet. Nutraceuticals are not intended to cure or treat disease, but they may be intended to affect the structure or function of the
body. Dietary supplements that contain structure/function claims on their labels must bear the disclaimer: “This statement has not been evaluated by the
FDA.  This  product  is  not  intended  to  diagnose,  treat,  cure,  or  prevent  any  disease.”  The  manufacturer  is  responsible  for  ensuring  the  accuracy  and
truthfulness of product claims; product claims are not approved by FDA. Dietary supplements also are subject to the Nutrition, Labeling and Education Act
(“NLEA”), which regulates health claims, ingredient labeling and nutrient content claims characterizing the level of a nutrient in a product.

The Company cannot anticipate how changes in regulations or determinations by regulatory agencies may evolve. Thus, application of many foreign, state
and federal regulations to the Company’s business operations is uncertain. Further, there are federal and state fraud and abuse laws, including anti-kickback
laws  and  limitations  on  physician  referrals  and  laws  related  to  off-label  promotion  of  prescription  drugs  that  may  or  may  not  be  directly  or  indirectly
applicable to the Company’s operations and relationships or the business practices of its customers. It is possible that a review of its business practices or
those of its customers by courts or regulatory authorities could result in a determination that may adversely affect the Company. In addition, the healthcare
regulatory  environment  may  change  in  a  way  that  restricts  existing  operations  or  growth.  The  healthcare  industry  is  expected  to  continue  to  undergo
significant changes for the foreseeable future, which could have an adverse effect on the Company’s business, financial condition and results of operations.
The Company cannot predict the effect of possible future legislation and regulation.

If  we  or  our  third-party  manufacturers  fail  to  comply  with  the  FDA’s  good  manufacturing  practice  regulations  or  fail  to  adequately,  timely,  or
sufficiently respond to an FDA Form 483 or subsequent Warning Letter, this could impair our ability to market our products in a cost-effective and
timely manner and could result in FDA enforcement action.

The FDA requires facilities that manufacture FDA-regulated products to comply with cGMP regulations, which cover the methods and documentation of
the design, testing, production, control, quality assurance, labeling, packaging, storage and shipping of our product. The Company does not manufacture
any of its products internally and instead relies on contract manufacturers to manufacture its products. We and our third-party manufacturers are required to
comply  with  cGMP.  The  FDA  audits  compliance  with  cGMP  and  related  regulations  through  periodic  announced  and  unannounced  inspections  of
manufacturing and other facilities. The FDA may conduct these inspections at any time.

The Company may be subject to fines, penalties, injunctions or other administrative actions if it is deemed to be promoting its nutritional or medical
foods products as a drug, or if it’s using false or misleading claims in its promotional materials.

The Company’s business and future growth depend on the development, use and ultimate sale of products that are subject to FDA regulation. Under the
U.S.  Federal  Food,  Drug,  and  Cosmetic  Act  and  other  laws,  the  Company  is  prohibited  from  promoting  its  nutritional  and  medical  foods  products  for
treatment of a condition or disease. Our promotional materials and marketing activities must comply with FDA and other applicable laws and regulations,
including laws and regulations prohibiting marketing claims that promote the off-label use of our products or that make false or misleading statements.
FDA also could conclude that a performance claim is misleading if it determines that there are inadequate non-clinical and/or clinical data supporting the
claim.

There is a risk that the FDA or other federal or state law enforcement authorities could determine that the nature and scope of our sales and marketing
activities may constitute the promotion of our products for use as a drug in violation of applicable law, or that our promotional materials include false or
misleading statements. The Company also faces the risk that the FDA or other regulatory authorities might pursue enforcement based on past activities that
the Company discontinued or changed, including sales activities, arrangements with institutions and doctors, educational and training programs and other
activities.

26

 
 
 
 
 
 
 
 
 
 
Government investigations are typically expensive, disruptive, burdensome and generate negative publicity. If its promotional activities are found to be in
violation of applicable law or if the Company agrees to a settlement in connection with an enforcement action, the Company would likely face significant
fines and penalties and would likely be required to substantially change its sales, promotion and educational activities. In addition, were any enforcement
actions against the Company or its senior officers to arise, the Company could be excluded from participation in U.S. government healthcare programs such
as Medicare and Medicaid.

The Company’s products may cause undesirable side effects or have other properties that could delay or prevent any required regulatory approval, limit
the commercial potential or result in significant negative consequences following any potential marketing approval.

If  the  Company’s  products,  including  Lumega-Z,  GlaucoCetin  or  the  NutriGuard  line  of  products,  are  associated  with  undesirable  side  effects  or  have
characteristics that are unexpected, the Company may need to abandon its development or limit development to certain uses or subpopulations in which the
undesirable side effects or other characteristics are less prevalent, less severe or more acceptable from a risk-benefit perspective. The Company also may
have to remove a commercialized product from the market as consequence of serious adverse events associated with the product. Any serious adverse or
undesirable side effects identified during the development of the Company’s products, could interrupt, delay or halt commercialization and/or could result
in the additional regulatory requirements by the FDA or other regulatory authorities, and in turn prevent the Company from commercializing its product
candidates and generating revenues from their sale.

A  key  part  of  the  Company’s  business  strategy  is  to  establish  collaborative  relationships  to  commercialize  and  develop  its  product  candidates.  The
Company  may  not  succeed  in  establishing  and  maintaining  collaborative  relationships,  which  may  significantly  limit  its  ability  to  develop  and
commercialize its products successfully, if at all.

A key part of the Company’s business strategy is to establish collaborative relationships to commercialize and fund development of its product candidates.
The Company is currently a party to several collaborative relationships.

While the Company believes that these collaborative relationships help further validate our products, these relationships are not material to the Company
because none of these relationships is exclusive, there are many potential collaborative partners available, and the Company and each collaborator is free to
enter into other collaborative relationships as needed.

The Company may not be able to negotiate collaborations on acceptable terms, if at all, and if it does enter into collaborations, these collaborations may not
be successful. The Company’s current and future success depends in part on its ability to enter into successful collaboration arrangements. If the Company
is unable to establish and maintain collaborative relationships on acceptable terms or to successfully transition terminated collaborative agreements, the
Company may have to delay or discontinue further development of one or more of its product candidates, undertake development and commercialization
activities at its own expense or find alternative sources of capital. Consequently, if it is unable to enter into, maintain or extend successful collaborations,
the Company’s business may be harmed.

The Company’s long-term success may depend upon the successful development and commercialization of products other than its current products.

The Company’s long-term viability and growth may depend upon the successful development and commercialization of products other than its current line
of  products.  Product  development  and  commercialization  is  very  expensive  and  involves  a  high  degree  of  risk.  Only  a  small  number  of  research  and
development programs result in the commercialization of a product. Product development is a complex and time-consuming process. If the Company fails
to  adequately  manage  the  research,  development,  execution  and  regulatory  aspects  of  new  product  development  it  may  fail  to  launch  new  products
altogether.

27

 
 
 
 
 
 
 
 
 
 
 
Patent litigation is common in the pharmaceutical and biopharmaceutical industries. Any litigation or claim against the Company may cause it to incur
substantial  costs  and  could  place  a  significant  strain  on  its  financial  resources,  divert  the  attention  of  management  from  its  business  and  harm  the
Company’s reputation.

While the Company is not a pharmaceutical or a biopharmaceutical company, as a health sciences company, the Company’s medical foods, nutraceuticals
or its medical devices may come into competition with products in the medical foods and related industries, such as pharmaceuticals, biologics or dietary
supplements. There has been substantial litigation in the pharmaceutical and biopharmaceutical industries with respect to the manufacture, use and sale of
new  products  that  are  the  subject  of  conflicting  patent  rights.  For  the  most  part,  these  lawsuits  relate  to  the  validity,  enforceability  and  infringement  of
patents.  The  Company  expects  it  will  rely  upon  patents,  trade  secrets,  know-how,  continuing  technological  innovations  and  licensing  opportunities  to
develop and maintain its competitive position. The Company may find it necessary to initiate claims to defend its intellectual property rights as a result.
Other parties may have issued patents or be issued patents that may prevent the sale of the Company’s products or know-how or require the Company to
license such patents and pay significant fees or royalties to produce its products. In addition, future patents may issue to third parties which the Company’s
technology  may  infringe.  Because  patent  applications  can  take  many  years  to  issue,  there  may  be  applications  now  pending  of  which  the  Company  is
unaware that may later result in issued patents that the Company’s products may infringe.

Intellectual property litigation, regardless of outcome, is expensive and time-consuming, and could divert management’s attention from our business and
have a material negative effect on our business, operating results or financial condition. If such a dispute were to be resolved against us, the Company may
be required to pay substantial damages, including treble damages and attorney’s fees to the party claiming infringement if the Company were to be found to
have willfully infringed a third party’s patent. The Company may also have to develop non-infringing technology, stop selling any products it develops,
cease using technology that contains the allegedly infringing intellectual property or enter into royalty or license agreements that may not be available on
acceptable or commercially practical terms, if at all. The Company’s failure to develop non-infringing technologies or license the proprietary rights on a
timely basis could harm its business. Modification of any products the Company develops or development of new products thereafter could require the
Company to become subject to other requirements of the FDA and other regulatory bodies, which could be time-consuming and expensive. In addition,
parties  making  infringement  claims  may  be  able  to  obtain  an  injunction  that  would  prevent  the  Company  from  selling  any  products  it  develops,  which
could harm its business.

The Company’s competitors may develop products similar to the Company’s medical foods, medical devices and nutraceuticals, and the Company may
therefore need to modify or alter its business strategy, which may delay the achievement of its goals.

Competitors  may  develop  products  with  similar  characteristics  to  our  products.  Such  similar  products  marketed  by  larger  competitors  could  hinder  the
Company’s efforts to penetrate the market.

Many large competitors have substantially greater financial, research and development, manufacturing and marketing experience and resources than we do
and represent substantial long-term competition for us. Such companies may develop products that are safer, more effective or less costly than any that we
may develop. Such companies also may be more successful than we are in manufacturing, sales and marketing.

As a result, the Company may be forced to modify or alter its business and regulatory strategy and sales and marketing plans, as a response to changes in
the market, competition and technology limitations, among others. Such modifications may pose additional delays in achieving the Company’s goals.

If the Company is unable to develop its own sales, marketing and distribution capabilities, or if it is not successful in contracting with third parties for
these services on favorable terms, or at all, revenues from product sales could be limited.

The  Company  currently  has  a  sales  force  consisting  of  a  sales  manager  and  four  salespeople.  To  commercialize  our  products  successfully,  we  have  to
develop more robust capabilities internally or collaborate with third parties that can perform these services for us. In the process of commercializing our
products, we may not be able to hire the necessary experienced personnel and build sales, marketing and distribution operations capable of successfully
launching new products and generating sufficient product revenues. In addition, establishing such operations takes time and involves significant expense.

28

 
 
 
 
 
 
 
 
 
 
 
If the Company decides to enter into co-promotion or other licensing arrangements with third parties, we may be unable to identify acceptable partners
because the number of potential partners is limited and because of competition from others for similar alliances with potential partners. Even if we are able
to identify one or more acceptable partners, we may not be able to enter into any partnering arrangements on favorable terms, or at all. If we enter into any
partnering arrangements, our revenues are likely to be lower than if we marketed and sold our products ourselves.

In addition, any revenues the Company receives would depend upon our partners’ efforts which may not be adequate due to lack of attention or resource
commitments, management turnover, and change of strategic focus, further business combinations or other factors outside of our control. Depending upon
the terms of our agreements, the remedies we have against an under-performing partner may be limited. If we were to terminate the relationship, it may be
difficult or impossible to find a replacement partner on acceptable terms, or at all.

Product  liability  lawsuits  against  the  Company  could  divert  its  resources  and  could  cause  it  to  incur  substantial  liabilities  and  to  limit
commercialization of Company products.

We  face  a  risk  of  product  liability  exposure  related  to  the  use  of  our  products,  including  Lumega-Z,  GlaucoCetin  and  the  NutriGuard  product  line  of
nutraceuticals. If we cannot successfully defend ourselves against claims that our product candidates or products caused injuries, we will incur substantial
liabilities. Regardless of merit or eventual outcome, liability claims may result in:

● decreased demand for any product candidates or products that we develop;
● injury to our reputation and significant negative media attention;
● significant costs to defend the related litigation;
● loss of revenue; and
● reduced time and attention of our management to pursue our business strategy.

Our insurance policies may not fully cover liabilities that we may incur in the event of a product liability lawsuit. We may not be able to maintain insurance
coverage at a reasonable cost or in an amount adequate to satisfy any liability that may arise.

The Company may be unsuccessful in expanding its product distribution outside the United States.

To the extent we continue to offer our products outside the United States, we expect that we may be dependent on third-party distribution relationships.
Distributors  may  not  commit  the  necessary  resources  to  market  and  sell  our  products  to  the  level  of  our  expectations.  If  distributors  do  not  perform
adequately, or we are unable to locate distributors in particular geographic areas, our ability to realize long-term international revenue growth would be
materially adversely affected.

Additionally, our products may require regulatory clearances and approvals from jurisdictions outside the United States. We expect that we will be subject
to and required to comply with local regulatory requirements before selling our products in those jurisdictions. We are not certain that we will be able to
obtain these clearances or approvals or compliance requirements on a timely basis, or at all.

We now sell our products to customers outside the U.S. and we intend to continue expansion of our international operations. As a result, our business

is increasingly exposed to risks inherent in international operations. These risks, which can vary substantially by location, include the following:

●

governmental laws,  regulations  and  policies  adopted  to  manage  national  economic  and  macroeconomic  conditions,  such  as  increases  in  taxes,
austerity measures that may impact consumer spending, monetary policies that may impact inflation rates, currency fluctuations and sustainability
of resources;

29

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
●

●

●

●

●

●

●

●

●

changes in environmental, health and safety regulations, such as the continued implementation of the European Union’s REACH regulations and
similar regulations that are being evaluated and adopted in other markets, and the burdens and costs of our compliance with such regulations;

increased environmental, health and safety regulations or the loss of necessary environmental permits in certain countries, arising from growing
consumer  sensitivity  concerning  the  inclusion  of  flavor  additives  in  food  products  and  the  fact  that  regulators  perceive  nutraceuticals,  medical
foods and functional food products as having medicinal attributes;

the imposition of or changes in tariffs, quotas, trade barriers, other trade protection measures and import or export licensing requirements, by the
U.S. or other Countries, which could adversely affect our cost or ability to import raw materials or export our flavors and fragrance products to
surrounding markets;

risks and costs arising from language and cultural differences;

changes  in  the  laws  and  policies  that  govern  foreign  investment  in  the  countries  in  which  we  operate,  including  the  risk  of  expropriation  or
nationalization, and the costs and ability to repatriate the profit that we generate in these countries;

risks and costs associated with political and economic instability, bribery and corruption, anti-American sentiment, and social and ethnic unrest in
the countries in which we operate;

difficulty in recruiting and retaining trained local personnel;

natural disasters, pandemics or international conflicts, including terrorist acts, or national and regional labor strikes in the countries in which we
operate, which could interrupt our operations or endanger our personnel; or

the risks of operating in developing or emerging markets in which there are significant uncertainties regarding the interpretation, application and
enforceability of laws and regulations and the enforceability of contract rights and intellectual property rights.

Manufacturing risks and inefficiencies may adversely affect the Company’s ability to produce products.

We  engage  third  parties  to  manufacture  our  products  in  sufficient  quantities  and  on  a  timely  basis,  while  maintaining  product  quality,  acceptable
manufacturing costs and complying with regulatory requirements. In determining the required quantities of our products and the manufacturing schedule,
we must make significant judgments and estimates based on historical experience, inventory levels, current market trends and other related factors. Because
of the inherent nature of estimates, there could be significant differences between our estimates and the actual amounts of products we require. If we are
unable to obtain from one or more of our vendors the needed materials or components that meet our specifications on commercially reasonable terms, or at
all, we may not be able to meet the demand for our products. While we have not arranged for alternate suppliers, and it may be difficult to find alternate
suppliers in a timely manner and on terms acceptable to us, we believe that there are multiple alternative sources, suppliers and manufacturers available for
our products and devices in the event of a termination or a disagreement with any current vendor. Additionally, our supply chain may be jeopardized for a
period of time due to the COVID-19 outbreak.

Security breaches and other disruptions could compromise the Company’s information and expose it to liability, which would cause its business and
reputation to suffer.

In the ordinary course of our business, we collect and store sensitive data, including intellectual property, our proprietary business information and that of
our customers and business partners, including personally identifiable information of our customers, some of which is stored on our network and some of
which is stored with our third-party E-commerce vendor. Despite our security measures, our information technology and infrastructure may be vulnerable
to  attacks  by  hackers  or  breached  due  to  operator  error,  malfeasance  or  other  disruptions.  Any  such  breach  could  compromise  our  network  and  the
information stored there could be accessed, publicly disclosed, lost or stolen. Any such access, disclosure or other loss of information could result in legal
claims or proceedings, liability under laws that protect the privacy of personal information, disrupt our operations, and damage our reputation, which could
adversely affect our business.

30

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The Company’s products and facility and the facilities of its manufacturers are subject to federal laws and regulations and certain requirements in the
State of California. Failure to comply with any applicable law or regulation could result in penalties and restrictions on the Company’s manufacturers’
ability to manufacture and the Company’s ability to distribute products. If any such action were to be imposed, it could have a material adverse effect
on the Company’s business and results of operations.

Although medical foods do not require pre-market approval by the FDA, manufacturers of medical foods and dietary supplements must be registered with
the FDA under a provision promulgated by the Public Health Security and Bioterrorism Preparedness and Response Act of 2002 (the “Bioterrorism Act”).
Manufactures  of  medical  devices  also  are  required  to  be  registered  with  the  FDA.  Manufacturers  of  FDA-regulated  products  are  subject  to  periodic
inspection by the FDA and state health authorities. The manufacture of our nutraceuticals, medical foods, and devices is outsourced in its entirety to three
third-party manufacturers. We are evaluating additional manufacturers for selection as second source or back-up providers.

Our products have not been reviewed by the FDA. There is no certainty that the FDA will favorably review our products or our manufacturers’ facilities. If
the outcome of an inspection is negative or if we or our manufacturers fail to comply with any law or regulation, we could be subject to penalties and
restrictions on our manufacturers’ ability to manufacture and distribute products. Any such action may result in a material adverse effect on our business
and results of operations. For a more complete discussion of the laws and regulations to which we are subject, see the section of this annual report titled
“Business - Government Regulation.”

The Company’s billings and revenues are derived from a limited number of customers and the loss of any one or more of them may have an immediate
adverse effect on its financial results.

In the years ended December 31, 2020 and 2019, the Company’s billings were derived from a limited number of individual customers and distributors.
During the year ended December 31, 2020, the Company had one customer who accounted for approximately 47% of the Company’s sales; and during the
year  ended  December  31,  2019,  the  Company  had  one  customer  who  accounted  for  approximately  22%  of  the  Company’s  sales.  Customers  may  stop
purchasing our products with little or no warning. Loss of customers may have an immediate adverse effect on our financial results.

If  customers  do  not  accept  the  Company’s  products  or  delay  in  deciding  whether  to  recommend  the  Company’s  products  and  services,  its  business,
financial condition and results of operations may be adversely affected.

Our  business  model  depends  on  our  ability  to  sell  our  products.  Acceptance  of  our  products  requires  physicians  to  use  our  MapcatSF  to  measure  the
macular  protective  pigment  in  their  patients’  eyes,  understand  and  appreciate  the  benefits  of  Lumega-Z  and  GlaucoCetin  and  nutraceuticals  in  order  to
recommend them to their patients, and to understand the benefits of visual acuity testing using the CSV-2000 device. We cannot assure you that physicians
will integrate our products into their treatment plans or patient recommendations. Achieving market acceptance for our products and services will require
substantial sales and marketing efforts and the expenditure of significant financial and other resources to create awareness and demand by participants in
the  healthcare  industry.  If  we  fail  to  achieve  broad  acceptance  of  our  products  by  physicians,  and  other  healthcare  industry  participants  or  if  we  fail  to
position our products as an ocular health remedy, our business, financial condition and results of operations may be adversely affected.

31

 
 
 
 
 
 
 
 
 
If the Company is deemed to infringe on the proprietary rights of third parties, it could incur unanticipated expense and be prevented from providing its
products and services.

We could be subject to intellectual property infringement claims as the number of our competitors grows and if our products or the functionality of our
products overlap with patents of our competitors. While we do not believe that we have infringed or are infringing on any proprietary rights of third parties,
we cannot assure you that infringement claims will not be asserted against us or that those claims will be unsuccessful. We could incur substantial costs and
diversion of management resources defending any infringement claims whether or not such claims are ultimately successful. Furthermore, a party making a
claim  against  us  could  secure  a  judgment  awarding  substantial  damages,  as  well  as  injunctive  or  other  equitable  relief  that  could  effectively  block  our
ability to provide products or services. In addition, we cannot assure you that licenses for any intellectual property of third parties that might be required for
our products or services will be available on commercially reasonable terms, or at all.

The Company’s business depends on its intellectual property rights, and if it is unable to protect them, its competitive position may suffer.

Our business plan is predicated on our proprietary technology. Accordingly, protecting our intellectual property rights is critical to our continued success
and our ability to maintain our competitive position. Our goal is to protect our proprietary rights through a combination of patent, trademark, trade secret
and  copyright  law,  confidentiality  agreements  and  technical  measures.  We  generally  enter  into  non-disclosure  agreements  with  our  employees  and
consultants and limit access to our trade secrets and technology. We cannot assure you that the steps we have taken will prevent misappropriation of our
technology. Misappropriation of our intellectual property would have an adverse effect on our competitive position.

Our  success,  competitive  position,  and  future  revenues  will  depend,  in  part,  on  our  ability  to  obtain  and  maintain  patent  protection  for  our  products,
methods, processes, and other technologies; to preserve our trade secrets; to obtain trademarks for our name, logo and products; to prevent third parties
from infringing our proprietary rights; and to operate without infringing the proprietary rights of third parties. To counter infringement or unauthorized use
by third parties, we may be required to file infringement claims, which can be expensive and time-consuming.

The patent process is subject to numerous risks and uncertainties, and there can be no assurance that we will be successful in protecting our products by
obtaining and defending patents. These risks and uncertainties include the following:

● Claims of issued patents, and the claims of any patents which may be issued in the future and be owned by or licensed to the Company may be
challenged by third parties, resulting in patents being deemed invalid, unenforceable, or narrowed in scope, a third party may circumvent any such
issued patents, or such issued patents may not provide any significant commercial protection against competing products;

● Our  competitors,  many  of  which  have  substantially  greater  resources  than  we  do  and  many  of  which  have  made  significant  investments  in
competing technologies, may seek, or may already have obtained, patents that will limit, interfere with, or eliminate our ability to make, use, and
sell our potential products either in the United States or in international markets; and

● The legal systems of some foreign countries do not encourage the aggressive enforcement of patents, and countries other than the United States
may have less restrictive patent laws than those upheld by United States courts, allowing foreign competitors the ability to exploit these laws to
create,  develop,  and  market  competing  products.  Thus,  the  Company’s  foreign  patents  may  not  be  enforceable  to  the  same  extent  as  the
counterpart U.S. patents.

In  addition,  the  USPTO,  and  patent  offices  in  other  jurisdictions  have  often  required  that  patent  applications  concerning  pharmaceutical  and/or
biotechnology-related inventions be limited or narrowed substantially to cover only the specific innovations exemplified in the patent application, thereby
limiting  the  scope  of  protection  against  competitive  challenges.  Thus,  even  if  we  or  any  of  our  licensors  are  able  to  obtain  patents,  the  patents  may  be
substantially narrower than anticipated.

The  Company  must  attract  and  retain  quality  management  and  employees  in  order  to  manage  its  growth.  Failure  to  do  so  may  result  in  slower
expansion.

In order to support the growth of our business and the additional obligations that come with being an exchange-listed company, we will need to expand our
senior  management  team  and  attract  and  retain  quality  employees.  There  is  no  assurance  that  we  will  be  capable  of  attracting  and  retaining  quality
executives and integrating those individuals into our management system. Without experienced and talented management and employees, the growth of our
business may be adversely impacted.

32

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The  Company’s  ability  to  attract  and  retain  qualified  members  of  our  board  of  directors  may  be  impacted  due  to  new  state  laws,  including  recently
enacted gender quotas.

In September 2018, California enacted SB 826 requiring public companies headquartered in California to maintain minimum female representation on their
boards of directors as follows: by the end of 2019, at least one woman on its board, by the end of 2020, public company boards with five members will be
required to have at least two female directors, and public company boards with six or more members will be required to have at least three female directors.

In  September  2020,  California  enacted  AB  979,  which  requires  that  by  the  end  of  2021  California-headquartered  public  companies  have  at  least  one
director on their boards who is from an underrepresented community, defined as “an individual who self-identifies as Black, African American, Hispanic,
Latino, Asian, Pacific Islander, Native American, Native Hawaiian, or Alaska Native, or who self-identifies as gay, lesbian, bisexual, or transgender.”

In addition to that initial 2021 requirement, the law mandates that the number of directors from underrepresented communities be increased by the end of
calendar year 2022, depending on the size of the board.

In  addition,  NASDAQ  has  proposed  to  adopt  new  listing  rules  related  to  board  diversity  and  disclosure.  If  approved  by  the  SEC,  the  new  listing  rules
would  require  all  companies  listed  on  Nasdaq’s  U.S.  exchanges  to  publicly  disclose  consistent,  transparent  diversity  statistics  regarding  their  board  of
directors.  Additionally,  the  rules  would  require  most  Nasdaq-listed  companies  to  have,  or  explain  why  they  do  not  have,  at  least  two  diverse  directors,
including one who self-identifies as female and one who self-identifies as either an underrepresented minority or LGBTQ+.

Failure  to  achieve  designated  minimum  gender  and  diversity  levels  in  a  timely  manner  exposes  such  companies  to  financial  penalties  and  reputational
harm. We cannot assure that we can recruit, attract and/or retain qualified members of the board and meet gender and diversity quotas as a result of the
California laws or future NASDAQ rules, which may expose us to penalties and/or reputational harm.

Our acquisition strategy involves a number of risks.

We  are  regularly  engaged  in  acquisition  discussions  with  other  companies  and  anticipate  that  one  or  more  potential  acquisition  opportunities,
including  those  that  would  be  material  or  could  involve  businesses  with  operating  characteristics  that  differ  from  our  existing  business  operations,  may
become available in the near future. If and when appropriate acquisition opportunities become available, we intend to pursue them actively. Acquisitions
involve a number of special risks, including:

● failure of the acquired business to achieve expected results, as well as the potential impairment of the acquired assets if operating results decline
after acquisition;
● diversion of management’s attention;
● additional financing, if necessary and available, which could increase leverage and costs, dilute equity, or both;
● the potential negative effect on our financial statements from the increase in goodwill and other intangibles;
● difficulties in integrating the operations, systems, technologies, products and personnel of acquired companies;
● initial dependence on unfamiliar supply chains or relatively small supply partners;
● the potential loss of key employees, customers, distributors, vendors and other business partners of the companies we acquire after the acquisition;
● the high cost and expenses of identifying, negotiating and completing acquisitions; and
● risks associated with unanticipated events or liabilities.

These risks could have a material adverse effect on our business, results of operations and financial condition. We have faced, and expect to continue
to  face,  intense  competition  for  acquisition  candidates,  which  may  limit  our  ability  to  make  acquisitions  and  may  lead  to  higher  acquisition  prices.  We
cannot assure you that we will be able to identify, acquire or manage profitably any acquisition opportunity.

33

 
 
 
 
 
 
 
 
 
 
 
 
In order to expand the Company’s business into additional jurisdictions, it may need to comply with regulatory requirements specific to such states and
there can be no assurance that it will be able to initially meet such requirements or that it will be able to maintain compliance on an on-going basis.

While we believe Lumega-Z® and Glauco-CetinTM to be medical foods and not drugs, they are only available under the supervision of a physician. While
not available in pharmacies, we are mindful that the act of physicians prescribing, particularly if conducted across state lines, could potentially be subject to
certain pharmacy regulations. Each state has its own regulations concerning physician dispensing, restrictions on the corporate practice of medicine, anti-
kickback and false claims. In addition, each state has a board of pharmacy that regulates the sale and distribution of drugs and other therapeutic agents.
Some states require a physician to obtain a license to dispense prescription products. While we do not believe these pharmacy requirements are applicable,
should a pharmacy board or medical board determine otherwise, there can be no assurance that we will be able to comply with the regulations of particular
states into which we may expand or that we will be able to maintain compliance with the states in which we currently distribute our products. We currently
have Lumega-Z customers in Alabama, Alaska, California, Massachusetts, Connecticut, New York, Pennsylvania, New Jersey, Georgia, North Carolina,
South  Carolina,  Florida,  Kentucky,  Tennessee,  Kansas,  Indiana,  Illinois,  Minnesota,  Oklahoma,  Texas,  New  Mexico,  Mississippi,  Idaho,  Utah,  Nevada,
Arizona,  Washington,  Hawaii  Malaysia  and  Alberta,  Canada.  Our  inability  to  maintain  compliance  with  the  regulations  of  California  and  these  other
jurisdictions or expand our business into additional states may adversely affect our results of operations.

For distribution of products in Malaysia, China and throughout Asia, our nutritional compounds are affected by the regulatory agencies in each country.
Each country has unique requirements related to the amount of ingredients allowed in the product and the labelling of each product. We believe that by
obtaining regulatory approval in advance of marketing and distribution in each country, we will be protected from these regulatory restrictions affecting our
ongoing operations. However, many factors can affect our ability to maintain compliance that are out of our control, including the availability of approved
ingredients and sudden changes in regulatory restrictions imposed by each country.

The Company is subject to anti-corruption laws, as well as export control laws, customs laws, sanctions laws and other laws governing our operations.
If it fails to comply with these laws, it could be subject to civil or criminal penalties, other remedial measures and legal expenses, be precluded from
developing manufacturing and selling certain products outside the U.S. or be required to develop and implement costly compliance programs, which
could adversely affect its business, results of operations and financial condition.

Our operations are subject to anti-corruption laws, including the U.K. Bribery Act 2010, or Bribery Act, the U.S. Foreign Corrupt Practices Act, or FCPA,
and other anti-corruption laws that apply in countries where we do business (including in Malaysia) and may do business in the future, particularly as we
expand our sales and operations to foreign markets. The Bribery Act, FCPA and these other laws generally prohibit us, our officers, and our employees and
intermediaries from bribing, being bribed or making other prohibited payments to government officials or other persons to obtain or retain business or gain
some  other  business  advantage.  Compliance  with  the  FCPA,  in  particular,  is  expensive  and  difficult,  particularly  in  countries  in  which  corruption  is  a
recognized problem. In addition, the FCPA presents particular challenges in the pharmaceutical industry, because, in many countries, hospitals are operated
by the government, and doctors and other hospital employees are considered foreign officials. Certain payments to hospitals in connection with clinical
trials and other work have been deemed to be improper payments to government officials and have led to FCPA enforcement actions.

We may in the future operate in jurisdictions that pose a high risk of potential Bribery Act or FCPA violations, and we may participate in collaborations and
relationships with third parties whose actions could potentially subject us to liability under the Bribery Act, FCPA or local anti-corruption laws. In addition,
we  cannot  predict  the  nature,  scope  or  effect  of  future  regulatory  requirements  to  which  our  international  operations  might  be  subject  or  the  manner  in
which existing laws might be administered or interpreted. If we expand our operations outside of the U.S., we will need to dedicate additional resources to
comply with numerous laws and regulations in each jurisdiction in which we plan to operate.

In addition, various laws, regulations and executive orders also restrict the use and dissemination outside of the U.S., or the sharing with certain non-U.S.
nationals, of information classified for national security purposes, as well as certain products and technical data relating to those products. If we expand our
presence outside of the U.S., it will require us to dedicate additional resources to comply with these laws, and these laws may preclude us from developing,
manufacturing, or selling certain products and product candidates outside of the U.S., which could limit our growth potential and increase our development
costs.

34

 
 
 
 
 
 
 
 
 
We may not be completely effective in ensuring our compliance with all applicable anti-corruption laws, including the Bribery Act, the FCPA or other legal
requirements, including Trade Control laws. If we are not in compliance with the Bribery Act, the FCPA and other anti-corruption laws or Trade Control
laws, we may be subject to criminal and civil penalties, disgorgement and other sanctions and remedial measures, and legal expenses, which could have an
adverse impact on our business, financial condition, results of operations and liquidity. The Securities and Exchange Commission also may suspend or bar
issuers from trading securities on U.S. exchanges for violations of the FCPA’s accounting provisions. Any investigation of any potential violations of the
Bribery  Act,  the  FCPA,  other  anti-corruption  laws  or  Trade  Control  laws  by  U.K.,  U.S.  or  other  authorities  could  also  have  an  adverse  impact  on  our
reputation, our business, results of operations and financial condition.

The Company’s Second Amended and Restated Bylaws designates the Court of Chancery of the State of Delaware as the sole and exclusive forum for
certain  types  of  state  law  actions  and  proceedings  that  may  be  initiated  by  our  stockholders,  which  could  limit  our  stockholders’  ability  to  obtain  a
favorable judicial forum for disputes with us or our directors, officers, employees or agents.

Article XI of our Second Amended and Restated Bylaws, or our Bylaws, dictates that the Delaware Court of Chancery is the sole and exclusive forum for
certain  state  law  based  actions  including  certain  derivative  actions  or  proceedings  brought  on  behalf  of  the  Company;  an  action  asserting  a  breach  of
fiduciary duty owed by an officer, a director, employee or to the shareholders of the Company; any claim arising under Delaware corporate law; and any
action asserting a claim governed by the internal affairs doctrine.

This exclusive forum provision does not apply to suits brought to enforce any liability or duty created by the Securities Act or the Exchange Act or other
federal securities laws for which there is exclusive federal or concurrent federal and state jurisdiction.

This choice of forum provision may limit our stockholders’ ability to bring a claim in a judicial forum that it finds favorable for disputes with us or our
directors, officers, employees or agents, which may discourage such lawsuits against us and our directors, officers, employees and agents even though an
action, if successful, might benefit our stockholders. Stockholders who do bring a claim in the Court of Chancery could face additional litigation costs in
pursuing any such claim, particularly if they do not reside in or near Delaware. The Court of Chancery may also reach different judgments or results than
would other courts, including courts where a stockholder considering an action may be located or would otherwise choose to bring the action, and such
judgments or results may be more favorable to us than to our stockholders. Alternatively, if a court were to find this provision of our Bylaws inapplicable
to, or unenforceable in respect of, one or more of the specified types of actions or proceedings, we may incur additional costs associated with resolving
such matters in other jurisdictions, which could have a material adverse effect on our business, financial condition or results of operations.

Risks Related to the Company’s Industry

Any failure to comply with all applicable federal and state privacy and security requirements for the protection of patient information may result in
fines and other liabilities, which may adversely affect the Company’s results of operations and reputation.

The Health Insurance Portability and Accountability Act of 1996, Pub. L. No. 104-191 (“HIPAA”), the Health Information Technology for Economic and
Clinical Health Act, Title XIII of the American Recovery and Reinvestment Act of 2009 (the “HITECH Act”), and related regulations promulgated by the
Secretary (“HIPAA Regulations”) grant a number of rights to individuals as to their identifiable confidential medical information (called “Protected Health
Information”) and restrict the use and disclosure of Protected Health Information. Failure to comply with these confidentiality requirements may result in
penalties  and  sanctions.  In  addition,  certain  state  laws  may  impose  independent  obligations  upon  us  with  respect  to  patient-identifiable  medical
information. Moreover, various new laws relating to the acquisition, storage and transmission of patient medical information have been proposed at both
the federal and state level. These laws (collectively, the “State and Federal Privacy and Security Laws”) present different risks as to our sale of medical
foods.

35

 
 
 
 
 
 
 
 
 
 
When a physician recommends one or more of the Company’s medical foods to a patient, the Company typically receives an order from the customer, but
does not usually receive medical information. As part of the operation of its business, it is possible, however, that during communication with customers or
with  physicians  the  Company  might  receive  patient-identifiable  medical  information.  To  the  extent  the  Company  obtains  access  to  Protected  Health
Information,  it  must  ensure  it  complies  with  the  State  and  Federal  Privacy  and  Security  Laws.  Any  failure  to  comply  may  result  in  fines  and  other
liabilities, which may adversely affect its results of operations.

Any failure to comply with all applicable federal and state physician self-referral law (the “Stark Law”) may result in fines and other liabilities, which
may adversely affect the Company’s results of operations and reputation.

Congress enacted significant prohibitions against physician self-referrals in the Omnibus Budget Reconciliation Act of 1993. This law and its supporting
regulations, which have been amended and expanded substantially, are commonly referred to as the “Stark Law,” and prohibit a physician from making any
referral  of  a  Stark  Designated  Health  Service  (“DHS”)  to  an  entity  with  which  the  physician  has  any  kind  of  financial  relationship,  unless  all  the
requirements of a statutory or regulatory exception are met. Stark covered DHS include both outpatient prescription drugs and diagnostic testing that are
reimbursable by Medicare or Medicaid. Many states have similar laws, some of which can apply to all payors and not just governmental payors. While the
Company believes that its arrangements with its customers are in compliance with the federal and any state Stark Laws, the Stark Laws present different
levels of risks as to two of the Company’s lines of business: (1) sale of the Company’s medical foods and (2) sale of the Company’s medical devices.

Medical foods and medical devices are neither prescription drugs nor are they reimbursable under any federal program at present. Therefore, the Company
believes  that  the  federal  Stark  Law  is  not  applicable.  Further,  the  Company’s  believes  that  these  products  are  also  not  covered  under  any  potentially
applicable state Stark Laws. The federal Stark Law, however, includes an exception for the provision of in-office ancillary services, including a physician’s
dispensing  of  outpatient  prescription  drugs,  provided  that  the  physician  meets  specified  requirements.  To  the  extent  that  the  products  might  become
reimbursable  under  a  federal  program,  or  otherwise  become  covered  under  the  Stark  Law,  the  Company  believes  that  the  physicians  who  use  the
Company’s medical devices or recommend its medical foods to their patients are aware of these requirements. However, the Company does not monitor
their compliance and has no assurance that the physicians are in material compliance with the Stark Law. If it were determined that the physicians who use
the Company’s medical device or prescribe medical foods purchased from the Company were not in compliance with Stark II, it could potentially have an
adverse effect on the Company’s business, financial condition and results of operations.

Any failure to comply with all applicable federal and state anti-kickback laws may result in fines and other liabilities, which may adversely affect the
Company’s results of operations and reputation.

The federal anti-kickback statute (the “AKS”) applies to Medicare, Medicaid and other state and federal programs. AKS prohibits the solicitation, offer,
payment or receipt of remuneration in return for referrals or the purchase, or in return for recommending or arranging for the referral or purchase, of goods,
including drugs, covered by the federal health care programs. At present, the Company does not participate in any federal programs and its products are not
reimbursed by Medicare, Medicaid or any other state or federal program. The AKS is a criminal statute with criminal penalties, as well as potential civil
and  administrative  penalties.  The  AKS,  however,  provides  a  number  of  statutory  exceptions  and  regulatory  “safe  harbors”  for  particular  types  of
transactions.  Many  states  have  similar  fraud  and  abuse  laws  and  their  own  anti-kickback  laws,  some  of  which  can  apply  to  all  payors,  and  not  just
governmental payors. While the Company believes that it is in material compliance with both federal and state AKS laws, the AKS laws present different
levels of risks as to two of the Company’s lines of business: (1) sale of the Company’s medical foods, and (2) sale of the Company’s medical devices.

At  present,  the  Company’s  products  are  not  reimbursable  under  any  federal  program.  If,  however,  that  changes  in  the  future  and  it  were
determined that the Company was not in compliance with the AKS, the Company could be subject to liability, and its operations could be curtailed, which
could have a material adverse effect on the Company’s business, financial condition and results of operations. Moreover, if the activities of its customers or
other  entity  with  which  the  Company  has  a  business  relationship  were  found  to  constitute  a  violation  of  the  AKS  and  the  Company,  as  a  result  of  the
provision of products or services to such customer or entity, were found to have knowingly participated in such activities, the Company could be subject to
sanctions  or  liability  under  such  laws,  including  civil  and/or  criminal  penalties,  as  well  as  exclusion  from  government  health  programs. As  a  result  of
exclusion from government health programs, neither products nor services could be provided to any beneficiaries of any federal healthcare program.

36

 
 
 
 
 
 
 
 
 
Increased government involvement in healthcare could adversely affect the Company’s business.

U.S. healthcare system reform under the Medicare Prescription Drug, Improvement and Modernization Act of 2003, the Patient Protection and Affordable
Care Act of 2010 and other initiatives at both the federal and state level, could increase government involvement in healthcare, lower reimbursement rates
and otherwise change the business environment of our customers and the other entities with which we have a business relationship. While no federal price
controls are included in the Medicare Prescription Drug, Improvement and Modernization Act, any legislation that reduces physician incentives to dispense
medications  in  their  offices  could  adversely  affect  physician  acceptance  of  our  products.  We  cannot  predict  whether  or  when  future  healthcare  reform
initiatives at the federal or state level or other initiatives affecting our business will be proposed, enacted or implemented or what impact those initiatives
may have on our business, financial condition or results of operations. Our customers and the other entities with which we have a business relationship
could  react  to  these  initiatives  and  the  uncertainty  surrounding  these  proposals  by  curtailing  or  deferring  investments,  including  those  for  our  products.
Additionally, government regulation could alter the clinical workflow of physicians, hospitals and other healthcare participants, thereby limiting the utility
of  our  products  and  services  to  existing  and  potential  customers  and  curtailing  broad  acceptance  of  our  products  and  services.  Additionally,  new  safe
harbors to the federal Anti-Kickback Statute and corresponding exceptions to such law may alter the competitive landscape.

Risks Related to The Company’s Common Stock

The Company is an “emerging growth company” and it has elected to comply with certain reduced reporting and disclosure requirements which could
make its common stock less attractive to investors.

We are an “emerging growth company,” as defined in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”). For as long as we continue to be
an emerging growth company, we have elected to take advantage of exemptions from various reporting requirements that are applicable to other public
companies that are not emerging growth companies, including (1) not being required to comply with the auditor attestation requirements of Section 404 of
the Sarbanes-Oxley Act of 2002, which we refer to as the Sarbanes-Oxley Act, (2) reduced disclosure obligations regarding executive compensation in our
periodic reports and proxy statements and (3) exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and
stockholder approval of any golden parachute payments not previously approved. In addition, as an emerging growth company, we are only required to
provide two years of audited financial statements. As a result of these reduced reporting and disclosure requirements our financial statements may not be
comparable to SEC registrants not classified as emerging growth companies. We may be an emerging growth company for up to five years following the
first sale our equity securities in a public offering (April 2019), although circumstances could cause us to lose that status earlier, including if the market
value of our common stock held by non-affiliates exceeds $700.0 million before that time or if we have total annual gross revenue of $1.07 billion or more
during any fiscal year before that time, in which cases we would no longer be an emerging growth company as of the following December 31 or, if we issue
more  than  $1.0  billion  in  non-convertible  debt  during  any  three-year  period  before  that  time,  we  would  immediately  cease  to  be  an  emerging  growth
company. Even after we no longer qualify as an emerging growth company, we may still qualify as a “smaller reporting company” which would allow us to
take  advantage  of  many  of  the  same  exemptions  from  disclosure  requirements,  including  not  being  required  to  comply  with  the  auditor  attestation
requirements of Section 404 of the Sarbanes-Oxley Act and reduced disclosure obligations regarding executive compensation in our periodic reports and
proxy statements. We cannot predict if investors will find our common stock less attractive because we may rely on these exemptions. If some investors
find our common stock less attractive as a result, there may be a less active trading market for our common stock and our stock price may be more volatile.

Our independent registered public accounting firm will not be required to formally attest to the effectiveness of our internal control over financial reporting
until the later of our second annual report or the first annual report required to be filed with the SEC following the date we are no longer an “emerging
growth company” as defined in the JOBS Act.

Under the JOBS Act, emerging growth companies can also delay adopting new or revised accounting standards until such time as those standards apply to
private companies. We have elected to avail ourselves of this exemption from new or revised accounting standards and, therefore, will not be subject to the
same new or revised accounting standards as other SEC registrants that are not emerging growth companies.

37

 
 
 
 
 
 
 
 
 
Investors may find our common stock less attractive as a result of our election to utilize these exemptions, which could result in a less active trading market
for our common stock and/or the market price of our common stock may be more volatile.
Our stock price has fluctuated in the past, has recently been volatile and may be volatile in the future, and as a result, investors in our common stock
could incur substantial losses.

Our stock price has fluctuated in the past, has recently been volatile and may be volatile in the future. Additionally, over the course of the past year, our
shareholder base has increased in size due to the prevalence of new platforms and ease of access to stock trading brought on by new technologies. We may
incur rapid and substantial increases or decreases in our stock price in the foreseeable future that are unrelated to our operating performance or prospects. In
addition, the recent outbreak of the novel strain of coronavirus (COVID-19) has caused broad stock market and industry fluctuations. The stock market in
general and the market for biotechnology and pharmaceutical companies in particular have experienced extreme volatility that has often been unrelated to
the operating performance of particular companies. As a result of this volatility, investors may experience losses on their investment in our common stock.
The market price for our common stock may be influenced by many factors, including the following:

● investor reaction to our business strategy;

● investor reaction to our acquisition strategy;

● the success of competitive products or technologies;

● our continued compliance with the listing standards of NASDAQ;

● regulatory or legal developments in the United States and other countries, especially changes in laws or regulations applicable to our products;

● actions taken by regulatory agencies with respect to our products, manufacturing process or sales and marketing terms;

● variations in our financial results or those of companies that are perceived to be similar to us;

● the success of our efforts to acquire or in-license additional products or product candidates;

● developments concerning our collaborations or partners;

● declines in the market prices of stocks generally;

● trading volume of our common stock;

● sales of our common stock by us or our stockholders;

● general economic, industry and market conditions; and

● other events or factors, including those resulting from such events, or the prospect of such events, including war, terrorism and other international
conflicts, public health issues including health epidemics or pandemics, such as the recent outbreak of the novel coronavirus (COVID-19), and
natural disasters such as fire, hurricanes, earthquakes, tornados or other adverse weather and climate conditions, whether occurring in the United
States or elsewhere, could disrupt our operations, disrupt the operations of our suppliers or result in political or economic instability; and

These  broad  market  and  industry  factors  may  seriously  harm  the  market  price  of  our  common  stock,  regardless  of  our  operating  performance.  Further,
recent increases are inconsistent with any improvements in actual or expected operating performance, financial condition or other indicators of value. Since
the stock price of our common stock has fluctuated in the past, has been recently volatile and may be volatile in the future, investors in our common stock
could incur substantial losses. In the past, following periods of volatility in the market, securities class-action litigation has often been instituted against
companies. Such litigation, if instituted against us, could result in substantial costs and diversion of management’s attention and resources, which could
materially and adversely affect our business, financial condition, results of operations and growth prospects. There can be no guarantee that our stock price
will remain at current prices or that future sales of our common stock will not be at prices lower than those sold to investors.

38

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Additionally,  recently,  securities  of  certain  companies  have  experienced  significant  and  extreme  volatility  in  stock  price  due  short  sellers  of  shares  of
common stock, known as a “short squeeze.” These short squeezes have caused extreme volatility in those companies and in the market and have led to the
price per share of those companies to trade at a significantly inflated rate that is disconnected from the underlying value of the company. Many investors
who have purchased shares in those companies at an inflated rate face the risk of losing a significant portion of their original investment as the price per
share has declined steadily as interest in those stocks have abated. While we have no reason to believe our shares would be the target of a short squeeze,
there can be no assurance that we won’t be in the future, and you may lose a significant portion or all of your investment if you purchase our shares at a rate
that is significantly disconnected from our underlying value.

The Company does not intend to pay cash dividends to its stockholders, so you may not receive any return on your investment in the Company prior to
selling your interest in the Company.

We have never paid any dividends to our common stockholders and do not foresee doing so as a public company. We currently intend to retain any future
earnings  for  funding  growth  and,  therefore,  do  not  expect  to  pay  any  cash  dividends  in  the  foreseeable  future.  If  we  determine  that  we  will  pay  cash
dividends to the holders of our common stock, we cannot assure that such cash dividends will be paid on a timely basis. The success of your investment in
the Company will likely depend entirely upon any future appreciation. As a result, you will not receive any return on your investment prior to selling your
shares in our Company and, for the other reasons discussed in this “Risk Factors” section, you may not receive any return on your investment even when
you sell your shares in our Company.

The Company may require additional capital in the future to support its operations, and this capital has not always been readily available.

We may require additional debt or equity financing to fund our operations, including, but not limited to, working capital. Our limited operating history
makes it difficult to evaluate our current business model and future prospects. Accordingly, investors should consider our prospects in light of the costs,
uncertainties, delays and difficulties frequently encountered by companies in the early stages of development, as we have, in fact, encountered. Potential
investors should carefully consider the risks and uncertainties that a new company with a limited operating history and with limited funds, will face. In
particular, while we do not have current plans to re-prioritize our business plan, potential investors should consider that there is a significant risk that we
will not be able to:

● implement or execute our current business plan, which may or may not be sound;
● maintain our anticipated management and advisory team;
● raise sufficient funds in the capital markets to effectuate our business plan; and
● identify, acquire or successfully integrate any acquisition candidate.

If we raise additional funds through further issuances of equity or convertible debt securities, our existing shareholders could suffer significant dilution, and
any  new  equity  securities  we  issue  could  have  rights,  preferences  and  privileges  superior  to  those  of  holders  of  our  existing  capital  stock.  Any  debt
financing secured by us in the future could involve restrictive covenants relating to our capital raising activities and other financial and operational matters,
which  may  make  it  more  difficult  for  us  to  obtain  additional  capital  and  to  pursue  business  opportunities.  In  addition,  we  may  not  be  able  to  obtain
additional  financing  on  terms  favorable  to  us,  if  at  all.  If  we  are  unable  to  obtain  adequate  financing  or  financing  on  terms  satisfactory  to  us,  when  we
require it, our ability to continue to support our current operations and to respond to business challenges would be significantly limited. If we cannot access
the capital necessary to support our business, we would be forced to curtail our business activities or even shut down operations. If we cannot execute any
one of the foregoing or similar matters relating to our business, the business may fail, in which case you would lose the entire amount of your investment in
the Company.

We have identified a material weakness in our internal control over financial reporting. Failure to maintain effective internal controls could cause our
investors to lose confidence in us and adversely affect the market price of our common stock. If our internal controls are not effective, we may not be
able to accurately report our financial results or prevent fraud.

39

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Maintaining effective  internal  control  over  financial  reporting  and  effective  disclosure  controls  and  procedures  are  necessary  for  us  to  produce  reliable
financial statements. As discussed in Item 9A – “Controls and Procedures” of this Form 10-K, we have re-evaluated our internal control over financial
reporting and our disclosure controls and procedures and concluded that they were not effective as of December 31, 2020.

A material weakness is defined as a deficiency, or a combination of deficiencies, in internal control over financial reporting such that there is a reasonable
possibility  that  a  material  misstatement  of  our  annual  or  interim  financial  statements  will  not  be  prevented  or  detected  on  a  timely  basis.  The  material
weakness we identified was inadequate segregation of duties within accounting processes.

The  Company  is  committed  to  remediating  its  material  weaknesses  as  promptly  as  possible.  Implementation  of  the  Company’s  remediation  plans  has
commenced and is being overseen by the audit committee. However, there can be no assurance as to when these material weaknesses will be remediated or
that additional material weaknesses will not arise in the future. Even effective internal control can provide only reasonable assurance with respect to the
preparation and fair presentation of financial statements. Any failure to remediate the material weaknesses, or the development of new material weaknesses
in  our  internal  control  over  financial  reporting,  could  result  in  material  misstatements  in  our  financial  statements,  which  in  turn  could  have  a  material
adverse effect on our financial condition and the trading price of our common stock and we could fail to meet our financial reporting obligations.

The Company’s failure to meet the continued listing requirements of Nasdaq could result in a delisting of its common stock.

On September 20, 2019, we received notice from the Listing Qualifications staff (the “Staff”) of The Nasdaq Stock Market LLC (“Nasdaq”) indicating that,
based  upon  the  closing  bid  price  of  the  Company’s  common  stock  for  the  previous  30  consecutive  business  days,  the  Company  no  longer  satisfied  the
requirement to maintain a minimum bid price of $1.00 per share, as required by Nasdaq Listing Rule 5550(a)(2) (the “Bid Price Rule”).

In accordance with the Nasdaq Listing Rules, the Company was afforded 180 days, or until March 18, 2020, to regain compliance with the Bid Price Rule
by evidence of a closing bid price of at least $1.00 per share for a minimum of 10 consecutive business days. Thereafter, the Company had been afforded a
second 180-calendar day compliance period (which 180-day period was extended due to circumstances related to COVID-19), or until November 30, 2020,
to regain compliance with the Bid Price Rule.

The Company was unable to regain compliance with the Bid Price Rule by November 30, 2020. Accordingly, on December 1, 2020, the Company received
a  letter  from  the  Staff  notifying  it  that  its  Common  Stock  would  be  subject  to  delisting  from  Nasdaq  unless  the  Company  timely  appealed  Nasdaq’s
determination to a Nasdaq Listing Qualifications Panel (the “Panel”). The Company timely appealed Nasdaq’s determination to the Panel. 

On January 26, 2021, the Company received written notification that the Panel granted the Company an extension for continued listing through March 15,
2021.

40

 
 
 
 
 
 
 
 
 
 
On March 1, 2021, the Company filed a Certificate of Amendment to its Certificate of Incorporation, as amended, with the Secretary of State of the State of
Delaware  to  effectuate  a  one-for-six  (1:6)  reverse  stock  split  (the  “Reverse  Stock  Split”)  of  its  common  stock  without  any  change  to  its  par  value.
Proportional adjustments for the Reverse Stock Split were made to the Company’s outstanding common stock, stock options, and warrants as if the split
occurred at the beginning of the earliest period presented in this Annual Report.

On March 15, 2021, we received a letter from the Staff notifying us that we had regained compliance with the Bid Price Rule. The letter stated the staff had
determined that for the prior 10 consecutive business days the closing bid price of the Company’s common stock had been at $1.00 per share or greater and
that accordingly, the Company had regained compliance under the Bid Price Rule, and that the matter was now closed.

If we fail to satisfy the continued listing requirements of Nasdaq in the future, including the Bid Price Rule, Nasdaq may take steps to delist our common
stock. Such a delisting would likely have a negative effect on the price of our common stock and would impair your ability to sell or purchase our common
stock when you wish to do so. A delisting would adversely affect the liquidity, trading volume and likely the price of our common stock, causing the value
of an investment in us to decrease and having an adverse effect on our business, financial condition and results of operations.

The Company’s stock price may be volatile, and you may not be able to resell your shares at or above the purchase price.

The market price of our common stock is volatile and could fluctuate widely in price in response to various factors, many of which are beyond our control,
including the following:

● our ability to execute our business plan;
● changes in our industry;
● competitive pricing pressures;
● our ability to obtain working capital financing;
● additions or departures of key personnel;
● sales of our common stock;
● operating results that fall below expectations; and
● regulatory developments;

In  addition,  the  securities  markets  have  from  time-to-time  experienced  significant  price  and  volume  fluctuations  that  are  unrelated  to  the  operating
performance of particular companies. These market fluctuations may also materially and adversely affect the market price of our common stock.

ITEM 1B. UNRESOLVED STAFF COMMENTS

Not applicable.

ITEM 2. PROPERTIES

The Company’s address is 15150 Avenue of Science, Suite 200, San Diego, California 92128. The Company’s corporate offices are rented under a five-
year lease for approximately 9,605 square feet of space at a current rental of $12,336 per month. We believe these facilities will be adequate for our needs
during the foreseeable future.

In connection with the VectorVision acquisition, the Company assumed a lease agreement for 5,000 square feet of office and warehouse space in Greenville
Ohio which commenced October 1, 2017 through February 2023. 

41

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ITEM 3. LEGAL PROCEEDINGS

The Company is periodically the subject of various pending or threatened legal actions and claims arising out of its operations in the normal course of
business. Regardless of the outcome, such proceedings or claims can have an adverse impact on the Company because of defense and settlement costs,
diversion of resources and other factors, and there can be no assurances that favorable outcomes will be obtained. As of March 25, 2021, the Company is
not subject to any such proceedings or claims.

ITEM 4. MINE SAFETY DISCLOSURES

Not applicable.

PART II

ITEM  5.  MARKET  FOR  REGISTRANT’S  COMMON  EQUITY,  RELATED  STOCKHOLDER  MATTERS  AND  ISSUER  PURCHASES  OF
EQUITY SECURITIES

Market Information

The Company’s common stock is listed on The NASDAQ Capital Market under the symbol “GHSI.” As of March 25, 2021, there were approximately 169
record holders of the Company’s common stock.

Dividend Policy

The Company has not declared nor paid any cash dividend on its common stock, and it currently intends to retain future earnings, if any, to finance the
expansion  of  its  business,  and  the  Company  does  not  expect  to  pay  any  cash  dividends  in  the  foreseeable  future.  The  decision  whether  to  pay  cash
dividends on its common stock will be made by its board of directors, in its discretion, and will depend on the Company’s financial condition, results of
operations, capital requirements and other factors that its board of directors considers significant.

ITEM 6. SELECTED FINANCIAL DATA

Not applicable.

ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Presentation of Information

As  used  in  this  Annual  Report,  the  terms  “we,”  “us”  “our”  and  the  “Company”  mean  Guardion  Health  Sciences,  Inc.  and  its  subsidiaries  unless  the
context  requires  otherwise.  The  following  discussion  and  analysis  should  be  read  in  conjunction  with  the  Company’s  audited  (and  unaudited)  financial
statements and the related notes thereto. All dollar amounts in this Annual Report refer to U.S. dollars unless otherwise indicated. Certain prior period
amounts have been reclassified to conform to current period presentation.

Overview

Guardion Health Sciences, Inc. (the “Company” or “we”) was formed in December 2009 in California as a limited liability company under the name P4L
Health  Sciences,  LLC,  and  it  subsequently  changed  its  name  to  Guardion  Health  Sciences,  LLC.  On  June  30,  2015,  the  Company  converted  from  a
California limited liability company to a Delaware corporation, changing its name to Guardion Health Sciences, Inc.

The Company is a specialty health sciences company (1) that has developed medical foods and medical devices in the ocular health space and (2) that is
developing nutraceuticals that the Company believes will provide supportive health benefits to consumers.

42

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
We see opportunities to grow our business and create value by developing and distributing condition-specific, clinically proven nutrition, medical foods,
and  diagnostic  devices.  Our  portfolio  of  science-based,  clinically  supported  products  support  healthcare  professionals,  their  patients,  and  consumers  in
achieving health goals.

Recent Trends – Market Conditions

The COVID-19 pandemic has and will continue affecting economies and businesses around the world. The impacts of the pandemic could be material, but
due to the evolving nature of this situation, we are not able at this time to estimate the impact on our financial or operational results. Among the factors that
could impact our results are: effectiveness of COVID-19 mitigation measures; global economic conditions; consumer spending; work from home trends;
supply chain sustainability; and other factors. These factors could result in increased or decreased demand for our products and services and impact our
ability to serve customers.

Recent Developments

January and February 2021 At the Market Offerings

On January 8, 2021, we entered into the Sales Agreement and filed a prospectus supplement pursuant to which we could sell up to $10,000,000 worth of
shares of our common stock in an “at the market” offering through the Distribution Agent (the “January 2021 1st ATM Offering”). On January 15, 2021,
we completed the January 2021 1st ATM Offering, pursuant to which we sold an aggregate of 2,559,834 shares of our common stock, raised gross proceeds
of approximately $10,000,000 and net proceeds of approximately $9,500,000.

On January 28, 2021, we entered into the Sales Agreement and filed a prospectus supplement pursuant to which we could sell up to $25,000,000 worth of
shares of our common stock in an “at the market” offering through the Distribution Agent (the “January 2021 2nd ATM Offering”). On February 10, 2021,
we  completed  the  January  2021  2nd  ATM  Offering,  pursuant  to  which  we  sold  an  aggregate  of  5,006,900  shares  of  our  common  stock,  raised  gross
proceeds of approximately $25,000,000 and net proceeds of approximately $24,100,000.

In addition, in January 2021 and February 2021, the Company issued an aggregate of 1,647,691 shares of common stock upon the exercise of warrants and
received $3,608,509.

2019 Initial Public Offering and 2019 Follow-On Public Offerings

On April 9, 2019, the Company closed its initial public offering (the “IPO”) of 208,334 shares of common stock, par value $0.001 per share, at an IPO
price to the public of $24.00 per share resulting in net proceeds to the Company of $3,888,000 after all costs and expenses. The shares began trading on the
NASDAQ Capital Market on April 5, 2019 under the symbol “GHSI.”

On August 15, 2019, the Company completed a second public offering (the “August Offering”) of (i) 2,000,000 shares of common stock, (ii) pre-funded
warrants  exercisable  for  166,667  shares  of  common  stock  (the  “Pre-Funded  Warrants”),  and  (iii)  warrants  to  purchase  up  to  an  aggregate  of  2,166,667
shares of common stock (the “August Warrants”). The August Offering was conducted pursuant to an Underwriting Agreement, dated August 13, 2019 by
and between the Company and Maxim Group LLC and WallachBeth Capital, LLC. On August 16, 2019, the Company sold an additional 325,000 August
Warrants  upon  exercise  of  the  underwriters’  over-allotment  option.  The  net  proceeds  to  the  Company  from  the  August  Offering,  after  deducting
underwriting discounts and commissions and other estimated expenses were $4,944,340.

The public offering price was $2.64 per share of common stock and $0.01 per accompanying August Warrant. Each August Warrant represents the right to
purchase one share of common stock at an exercise price of $3.51 per share. The August Warrants are exercisable immediately, expire five years from the
date of issuance and provide that, beginning on the earlier of (i) September 11, 2019 and (ii) the date on which the common stock traded an aggregate of
more than 6,666,667 shares after the announcement of the pricing of the August Offering, and ending on the twelve (12) month anniversary thereof, each
August Warrant may be exercised at the option of the holder on a cashless basis at a ratio of one August Warrant for one share of common stock, in whole
or in part, if the weighted average price of the Common Stock on the trading day immediately prior to the exercise date fails to exceed the initial exercise
price of the August Warrant

43

 
 
 
 
 
 
 
 
 
 
 
 
 
 
On October 30, 2019, the Company completed a third public offering of 4,083,334 shares of its common stock (including 283,334 pre-funded warrants to
purchase common stock in lieu thereof) and Series B warrants to purchase up to 4,083,334 shares of the Company’s common stock. Each share of common
stock (or pre-funded warrant) was sold together with one Series B warrant to purchase one share of common stock at a combined price to the public of
$2.052 per share and Series B warrant. The shares of common stock or pre-funded warrants and the accompanying Series B warrants were sold together but
will be issued separately and will be immediately separable upon issuance. Net proceeds, after deducting underwriting discounts, commissions and offering
expenses, were approximately $7.4 million.

The Series B warrants are exercisable at a price of $2.05 per share of common stock and will expire five years from the date on which the Series B warrants
become initially exercisable.

Warrant Exercises

From  January  1,  2020  through  December  31,  2020,  the  Company  received  total  gross  proceeds  of  $5,451,892  from  the  exercise  of  2,656,868  warrants
issued in the Company’s October 2019 follow-on offering.

NutriGuard Acquisition

Effective September 20, 2019 (the “Effective Date”), the Company’s newly-formed wholly-owned subsidiary, NutriGuard Formulations, Inc., a Delaware
corporation  (“Buyer”),  entered  into  an  asset  purchase  agreement  (the  “Asset  Purchase  Agreement”)  with  NutriGuard  Research,  Inc.,  a  California
corporation (“NutriGuard”), and NutriGuard’s sole shareholder, Mark McCarty (the “NutriGuard Acquisition”).

Pursuant to the Asset Purchase Agreement, Buyer purchased from NutriGuard specified assets of the NutriGuard brand and business, primarily consisting
of inventory, trademarks, copyrights and other intellectual property. In exchange, Buyer agreed to pay a royalty fee to NutriGuard subsequent to meeting
certain financial performance metrics based on the operating results of the NutriGuard brand of products following the Effective Date. NutriGuard and Mr.
McCarty also agreed, among other terms, to no longer use the “NutriGuard” name upon the Effective Date.

Nutraceutical Sales to Malaysian Customer

In February 2020, the Company contracted with a Malaysian company to develop an immune-supportive formula for its consumer base. An initial order
was placed, and the Company completed shipment of the product, received payment in full, and recognized revenue for this order of $890,000 during the
year ended December 31, 2020.

Recent Accounting Pronouncements

See Note 1 to the financial statements regarding recent accounting pronouncements.

Concentration of Risk

Cash  balances  are  maintained  at  large,  well-established  financial  institutions.  At  times,  cash  balances  may  exceed  federally  insured  limits.  Insurance
coverage limits are $250,000 per depositor at each financial institution. The Company has never experienced any losses related to these balances.

44

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Critical Accounting Policies and Estimates

The  Company’s  financial  statements  have  been  prepared  in  conformity  with  accounting  principles  generally  accepted  in  the  United  States  of  America
(“GAAP”).  The  preparation  of  its  financial  statements  in  conformity  with  GAAP  requires  management  to  make  certain  estimates  and  assumptions  that
affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported
amounts  of  expenses  during  the  reporting  period.  Actual  results  could  differ  from  those  estimates.  The  Company’s  financial  statements  included  herein
include all adjustments, consisting of only normal recurring adjustments, necessary to present fairly the Company’s financial position, results of operations
and cash flows.

The  following  critical  accounting  policies  affect  the  more  significant  judgments  and  estimates  used  in  the  preparation  of  the  Company’s  financial
statements.

Revenue Recognition

The Company recognizes revenue in accordance with Accounting Standards Codification (ASC) 606, Revenue from Contracts with Customers. Revenue is
recognized when control of promised goods or services is transferred to the customer in an amount that reflects the consideration to which the Company
expects to be entitled in exchange for those products or services. The Company reviews its sales transactions to identify contractual rights, performance
obligations, and transaction prices, including the allocation of prices to separate performance obligations, if applicable.

All products sold by the Company are distinct individual products and are offered for sale as finished goods only, and there are no performance obligations
required post-shipment for customers to derive the expected value from them. Contracts with customers contain no incentives or discounts that could cause
revenue to be allocated or adjusted over time.

Shipping and handling activities are performed before the customer obtains control of the goods and therefore represent a fulfillment activity rather than a
promised service to the customer. Payments for sales of medical foods and dietary supplements are generally made by approved credit cards. Payments for
medical  device  sales  are  generally  made  by  check,  credit  card,  or  wire  transfer.  Historically  the  Company  has  not  experienced  any  significant  payment
delays from customers.

The Company provides a 30-day right of return to its retail customers. A right of return does not represent a separate performance obligation, but because
customers are allowed to return products, the consideration to which the Company expects to be entitled is variable. Upon evaluation of historical product
returns, the Company determined that less than one percent of products is returned, and therefore believes it is probable that such returns will not cause a
significant  reversal  of  revenue  in  the  future.  Due  to  the  insignificant  amount  of  historical  returns  as  well  as  the  standalone  nature  of  the  Company’s
products and assessment of performance obligations and transaction pricing for the Company’s sales contracts, the Company does not currently maintain a
contract asset or liability balance at this time. The Company assesses its contracts and the reasonableness of its conclusions on a quarterly basis.

Inventories

Inventories  are  stated  at  the  lower  of  cost  or  net  realizable  value,  with  cost  determined  on  a  first-in,  first-out  (“FIFO”)  basis.  The  Company  records
adjustments to its inventory for estimated obsolescence or diminution in net realizable value equal to the difference between the cost of the inventory and
the estimated net realizable value. The difference is recognized as a loss in the period in which it occurs. Once inventory has been written down, it creates a
new cost basis for inventory that is not subsequently written up.

Stock-Based Compensation

The Company periodically issues stock-based compensation to officers, directors, contractors and consultants for services rendered. Such issuances vest
and expire according to terms established at the issuance date.

45

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Stock-based payments to officers, directors, consultants, contractors, and employees, which include grants of employee stock options, are recognized in the
financial statements based on their fair values. Stock option grants, which are generally time or performance vested, are measured at the grant date fair
value and charged to operations on a straight-line basis over the vesting period. The fair value of stock options is determined utilizing the Black-Scholes
option-pricing model, which is affected by several variables, including the risk-free interest rate, the expected dividend yield, the expected life of the equity
award, the exercise price of the stock option as compared to the fair market value of the common stock on the grant date and the estimated volatility of the
common stock over the term of the equity award.

Plan of Operations

General Overview

Based on the availability of sufficient funding, the Company intends to increase its commercialization activities and capitalize on growth opportunities. Our
significant business development and commercialization activities include:

● expand the Company’s domestic sales and marketing efforts, including increased digital marketing to consumers and health care professionals;
● explore sales and marketing opportunities in foreign markets such as Asia and Europe;
● increase  the  marketing  and  production  of  Lumega-Z®  and  GlaucoCetinTM  to  support  the  additional  sales  resulting  from  increased  marketing  and

promotional activity;

● expand the Company’s direct-to-consumer capabilities for both medical foods and nutraceutical products;
● increase the utilization of medical research and clinical studies to support the Company’s products;
● increase  the  existing  NutriGuard  customer  base  through  NutriGuard  Formulations,  Inc.  and  build  on  its  product  platform,  by  making  NutriGuard
products available to customers directly through direct-to-consumer (DTC) channels, third party eCommerce platforms and through recommendations
by their physicians;

● utilize a team of experts and digital tools to educate and train eye care physicians on the benefits of our products;
● review our product portfolio to and improve the product and the customer experience;
● increased new product development to address unmet consumer needs;
● increased distribution of nutraceutical products, including more distribution via third party eCommerce retailers;
● improve the Company’s eCommerce capabilities, including installation of new SaaS ecommerce platform; and
● improve our approach and service levels to Eye Care Practitioners and customers.

In  addition  to  the  commercialization  and  business  development  activities  described  above,  we  will  also  seek  opportunities  to  utilize  mergers  and
acquisitions and similar transactions to advance our business strategy.

Results of Operations

Through  December  31,  2020,  the  Company  has  primarily  been  engaged  in  product  development,  commercialization,  building  infrastructure  and  raising
capital. The Company has incurred and will continue to incur significant expenditures for the development of its products and intellectual property, which
includes  medical  foods  and  medical  devices  for  the  treatment  of  various  eye  diseases  and  nutraceuticals. The  Company  had  limited  revenue  during  the
years ended December 31, 2020 and 2019.

46

 
 
 
 
 
 
 
 
 
 
Comparison of Years Ended December 31, 2020 and 2019

Revenue
Cost of goods sold (includes write down of inventory of $971,719
during the year ended December 31, 2020)

Gross profit (loss)
Operating expenses:
Research and development
Sales and marketing
General and administrative
Costs related to resignation of former officer (including the reversal
of previously recognized stock compensation expense of $965,295
during the year ended December 31, 2020)
Loss on sales of equipment
Equipment impairment
Goodwill impairment

Total operating expenses
Loss from operations
Other (income) expense:
Interest expense
Finance cost upon issuance of warrants
Change in fair value of derivative warrants

Net loss

Revenue

Years Ended
December 31,

2020
1,889,844    $

  $

2019

Change

902,937    $

986,907   

1,946,635   
(56,791)  

160,978   
1,450,205   
7,450,245   

(615,936)  
18,500   
30,948   
-   
8,494,940   
(8,551,731)  

341,315   
561,622   

194,311   
1,874,901   
7,425,827   

-   
-   
-   
1,563,520   
11,058,559   
(10,496,937)  

7,271   
-   
12,655   
(8,571,657)   $

258,365   
415,955   
(292,949)  
(10,878,308)   $

  $

1,605,320   
618,413   

(33,333)  
(424,696)  
24,418   

(615,936)  
18,500   
30,948   
(1,563,520)  
(2,563,619)  
(1,945,206)  

(251,094)  
(415,955)  
305,604   
2,306,651   

109%

470%
(110%)

(17%)
(23%)
0%

- 
- 
- 
(100%)
(23%)
19%

(97%)
(100%)
(104%)
21%

For the year ended December 31, 2020, revenue from product sales was $1,889,844 compared to $902,937 for the year ended December 31, 2019, resulting
in an increase of $986,907 or 109%. The increase is due primarily to a sale to a Malaysian company of $890,000 for an immune-supportive formula that
was delivered by the Company in June 2020.

Cost of Goods Sold

For the year ended December 31, 2020, cost of goods sold was $1,946,635 compared to $341,315 for the year ended December 31, 2019, resulting in an
increase  of  $1,605,320  or  470%.  One  part  of  the  increase  in  2020  reflects  the  costs  of  goods  sold  associated  with  the  Malaysian  order  noted  above.  In
addition,  as  a  result  of  the  deterioration  of  the  forecasted  marketability  of  certain  of  the  Company’s  inventory,  management  recorded  a  write-down  of
inventory  of  $971,719  in  cost  of  goods  sold  for  the  year  ended  December  31,  2020.  Without  the  impact  of  the  inventory  write-down  in  the  year  ended
December 31, 2020, cost of goods sold increased $633,601 or 186%.

Gross Profit (Loss)

For the year ended December 31, 2020, gross loss was $(56,791) compared to gross profit of $561,622 for the year ended December 31, 2019, resulting in
a decrease of $618,413 or 110%. Gross profit (loss) represented (3)% of revenues for the year ended December 31, 2020, versus 62% of revenue for the
year ended December 31, 2019. The lower gross profit in 2020 is primarily as a result of lower distributor pricing given to the Malaysian customer and the
write-down of certain inventory that increased cost of goods sold by $971,719.

47

 
 
 
 
 
   
 
 
 
 
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Research and Development

For  the  year  ended  December  31,  2020,  research  and  development  costs  were  $160,978  compared  to  $194,311  for  the  year  ended  December  31,  2019,
resulting in a decrease of $33,333 or 17%. Research and development costs in our current yearly-period consist primarily of clinical studies related to our
medical foods and nutraceuticals versus engineering efforts related to our medical devices in our prior period.

Sales and Marketing

For the year ended December 31, 2020, sales and marketing expenses were $1,450,205 compared to $1,874,901 for the year ended December 31, 2019.
The decrease in sales and marketing expenses of $424,696 or 23% compared to the prior period was primarily due to a decrease of trade show activity as a
result of COVID-19 “stay at home” measures.

General and Administrative

For the year ended December 31, 2020, general and administrative expenses were $7,450,245 compared to $7,425,827 for the year ended December 31,
2019. The increase of $24,418 or 0% compared to the prior period was primarily due to an increase in consulting costs, professional fees, and corporate
insurance costs, largely offset by a $1,266,000 decrease in stock compensation expense primarily related to the reversal of compensation from prior periods
related to forfeited unvested options of a former officer.

Goodwill Impairment

Management concluded that as of December 31, 2019, the fair value of the goodwill associated with the VectorVision acquisition was less than its carrying
amount. For the year ended December 31, 32019, the Company recorded a goodwill impairment charge of $1,563,520. There was no goodwill impairment
recorded in 2020.

Costs Related to Resignation of Former Officer

Effective June 15, 2020, Michael Favish resigned as Chief Executive Officer and as an employee of the Company and resigned from the Company’s Board
of Directors. Terms of the settlement agreement included the continuation of his previous annual salary of $325,000 during the following twelve months.
The full amount of stock compensation costs were recorded in costs related to resignation of former officer.

Mr.  Favish’s  unvested  options  at  the  time  of  his  separation  were  forfeited.  All  compensation  from  prior  periods  related  to  these  unvested  options  was
reversed, resulting in an adjustment to stock compensation expense during the year ended December 31, 2020 of $(965,295) that was recorded in costs
related to resignation of former officer.

In  connection  with  Mr.  Favish’s  separation,  the  expiration  date  of  his  vested  stock  options  was  extended  for  twelve  months  from  June  15,  2020.  In
accounting for the modification, the Company calculated the fair value of the vested options immediately before modification and immediately following
the modification and recorded incremental stock compensation charge of $24,359 in costs related to resignation of former officer.

Impairment Loss on Equipment Held for Sale

During June 2020, in an effort to reduce costs and focus on other segments of the business, the Company decided to wind down the Transcranial Doppler
Solutions, Inc. (“TDSI”) subsidiary and ceased its operations. The wind down was completed in July 2020. TDSI held a group of ultrasound machines as
fixed assets. The Company sold these machines, and recorded a loss on sale of $18,500 during the year ended December 31, 2020. There was no loss on
equipment during 2019.

Interest Expense

For  the  year  ended  December  31,  2020,  interest  expense  was  $7,271  compared  to  $258,365  for  the  year  ended  December  31,  2019.  The  decrease  of
$251,094 or 97%, was due primarily to the amortization of the valuation discount of the March 2019 convertible notes of $233,455 that was reflected as an
expense when the notes were converted to equity in April 2019.

48

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Finance Cost Upon Issuance of Warrants

Finance costs for the year ended December 31, 2020 were $0. Finance costs for the year ended December 31, 2019 were $415,955. The 2019 finance costs
result from the two transactions. First, in March 2019, the Company issued warrants to two convertible note holders pursuant to the anticipated completion
of the Company’s IPO (the IPO was completed on April 9, 2019), and due to the variable terms of both the exercise price and the number of warrants to be
issued, the warrants were accounted for as derivative liabilities at March 31, 2019. The fair value of the warrants at the closing of the IPO was determined
to  be  $436,034,  of  which  $250,000  was  recorded  as  a  valuation  discount,  and  $186,034  was  recorded  as  a  finance  cost.  Second,  on  April  4,  2019,  the
Company issued 10,417 warrants with an exercise price of $30.00 per share to the Underwriter in connection with the Company’s IPO, that were accounted
for as a derivative liability. The fair value of the warrants at the date of issuance was determined to be $229,921 and was recorded as a finance cost.

Change in Fair Value of Derivative Warrants

In 2019, the fair value of warrants classified as derivative liabilities totaled $665,955 upon issuance. During 2019, derivative warrants with a fair value of
$359,683 were reclassified to equity, and a decrease in the fair value of derivatives warrant liabilities of $292,949 was recorded. At December 31, 2019, the
balance of derivative warrant liabilities was $13,323. During 2020, an increase in the fair value of derivative warrant liabilities of $12,655 was recorded,
and at December 31, 2020, the balance of derivative warrant liabilities was $25,978. The decrease in change in derivative warrant liabilities was primarily
due to the reclassification of derivative warrant liabilities to equity in 2019. There was no such reclassification in 2020.

Net Loss

For  the  year  ended  December  31,  2020,  the  Company  incurred  a  net  loss  of  $8,571,657,  compared  to  a  net  loss  of  $10,878,308  for  the  year  ended
December 31, 2019. The decrease in net loss of $2,306,651 or 21% compared to the prior year period was primarily due to increased revenues, a decrease
in certain operating costs, and an offsetting increase to cost of goods sold for write off of inventory.

Segment Information

The following tables set forth our results of operations by segment:

The. Medical Foods and Nutraceuticals segment provides a portfolio of science-based, clinically supported nutrition, medical foods, and supplements. Our
products include, among others, Lumega-Z, GlaucoCetin and ImmuneSF.

The Medical Devices segment includes a portfolio of medical diagnostic devices currently focused on the ocular space and is the industry leader in contrast
testing. Our products include VectorVision CSV-1000, CSV-1000HGT, CSV-2000 and associated accessories as well as the MapcatSF.

49

 
 
 
 
 
 
 
 
 
 
 
 
See Note 13 for further details on our reportable segments.

Revenue

Cost of goods sold

Gross profit (loss)

For the Year Ended December 31, 2020

Medical 
Foods and

Corporate

Nutraceuticals    

Medical 
Devices

Total

$

4,500   

$

1,609,482    $

275,862    $

1,889,844 

2,478   

1,599,510   

344,647   

1,946,635 

2,022   

9,972   

(68,785)  

(56,791)

Stock compensation expense

544,127   

-   

544,127 

Operating expenses

Loss from operations

Revenue

Cost of goods sold

Gross profit

Stock compensation expense

Goodwill impairment charge

Operating expenses

Loss from operations

Revenue

3,757,945   

3,892,899   

299,969   

7,950,813 

$

(4,300,050)  

$

(3,882,927)   $

(368,754)   $

(8,551,731)

For the Year Ended December 31, 2019

Medical 
Foods and

Corporate

Nutraceuticals    

Medical 
Devices

Total

$

24,270   

$

444,657    $

434,010    $

902,937 

7,288   

155,212   

178,815   

341,315 

16,982   

289,445   

255,195   

561,622 

2,717,731   

-   

-   

-   

-   

2,717,731 

1,563,520   

1,563,520 

360,257   

5,308,508   

1,108,543   

6,777,308 

$

(3,061,006)  

$

(5,019,063)   $

(2,416,868)   $

(10,496,937)

For the year ended December 31, 2020, revenue from our Medical Foods and Nutraceuticals segment was $1,609,482 compared to $444,657 for the year
ended December 31, 2019, resulting in an increase of $1,164,825 or 262%. The increase is due primarily to the completion of an order to a Malaysian
customer for an immune-supportive formula that was delivered in June 2020 and the Company recognized revenue for this order of $890,000 at such time.
For the year ended December 31, 2020, revenue from our Medical Devices segment was $275,862 compared to $434,010 for the year ended December 31,
2019, resulting in a decrease of $158,148 or 36%, primarily as a result of medical facility and office closures due to COVID-19 “Stay at Home” orders. The
decrease was offset in part from the sale of a MapCat device in January 2020. The severity of the impact of the COVID-19 pandemic on the Company’s
business will continue to depend on a number of factors, including, but not limited to, the duration and severity of the pandemic and the extent and severity
of the impact on the Company’s customers, service providers and suppliers, all of which are uncertain and cannot be predicted.

Cost of Goods Sold

For the year ended December 31, 2020, cost of goods sold from our Medical Foods and Nutraceuticals segment was $1,599,510 compared to $155,212 for
the year ended December 31, 2019, resulting in an increase of $1,444,298 or 931%. The increase was primarily due to the increase in cost associated with
the Malaysian order in addition to a write down of $760,488 for allowance of excess and obsolete nutraceutical inventory. For the year ended December 31,
2020, cost of goods sold from our Medical Devices segment was $344,647 compared to $178,815 for the year ended December 31, 2019, resulting in an
increase  of  $165,832  or  93%.  The  increase  was  due  to  a  write  down  of  $211,231  for  allowance  of  excess  and  obsolete  medical  device  inventory.  In
addition, a $13,000 inventory adjustment affecting cost of sales due primarily to the write off of scrap materials was recorded in March 2020.

50

 
 
 
 
 
 
 
 
   
   
 
 
 
    
    
    
  
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
    
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
   
   
 
 
 
    
    
    
  
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
Gross Profit (Loss)

For  the  year  ended  December  31,  2020,  gross  loss  from  the  Medical  Foods  and  Nutraceuticals  segment  was  $9,972  compared  to  $289,445  for  the  year
ended December 31, 2019, resulting in a decrease of $279,473 or 97%. For the year ended December 31, 2020, gross profit from the Medical Devices
segment was $(68,785) compared to $255,195 for the year ended December 31, 2019, resulting in a decrease of $323,980 or 127 %. Gross loss represented
(3)% of revenues for the year ended December 31, 2020, versus 62% of revenue for the year ended December 31, 2019. The lower gross profit percentage
in FY 2020 is primarily a result of the write down of inventory.

Goodwill Impairment Charge

Management concluded that as of December 31, 2019, the fair value of the goodwill associated with the VectorVision acquisition was less than its carrying
amount. For the year ended December 31, 32019, the Company recorded a goodwill impairment charge of $1,563,520.

Liquidity and Capital Resources

Since its formation in 2009, the Company has devoted substantial effort and capital resources to the development and commercialization activities related
to its product candidates. For the year ended December 31, 2020, the Company incurred a net loss of $8,571,657 and used cash in operating activities of
$8,013,929. At December 31, 2020, the Company had cash on hand of $8,518,732 and working capital of $8,021,152. Subsequent to December 31, 2020,
the Company sold an aggregate of 7,566,734 shares of its common stock for net proceeds of approximately $33,600,000 in two offerings, one completed in
January 2021, and one completed in February 2021. In addition, in January and February 2021, the Company issued an aggregate of 1,647,691 shares of
common stock upon the exercise of warrants and received cash proceeds of $3,608,509. Notwithstanding the net loss for 2020, management believes that
its current cash balance, plus net proceeds from issuance of common stock and exercise of warrants in January 2021 and February 2021, is sufficient to
fund operations for at least one year from the date the Company’s 2020 financial statements are issued.

The  Company’s  financing  has  historically  come  primarily  from  the  issuance  of  convertible  notes,  promissory  notes  and  from  the  sale  of  common  and
preferred stock. The Company will continue to incur significant expenses for continued commercialization activities related to its medical foods, medical
devices  and  its  nutraceuticals  product  line,  and  building  its  infrastructure.  Development  and  commercialization  of  medical  foods,  medical  devices  and
nutraceuticals  involves  a  lengthy  and  complex  process.  Additionally,  the  Company’s  long-term  viability  and  growth  may  depend  upon  the  successful
development and commercialization of new complementary products or product lines.

The Company may continue to seek to raise additional debt and/or equity capital to fund future operations and acquisitions as necessary, but there can be no
assurances  that  the  Company  will  be  able  to  secure  such  additional  financing  in  the  amounts  necessary  to  fully  fund  its  operating  requirements  on
acceptable  terms  or  at  all.  Over  time,  if  the  Company  is  unable  to  access  sufficient  capital  resources  on  a  timely  basis,  the  Company  may  be  forced  to
reduce or discontinue its technology and product development programs and curtail or cease operations.

Sources and Uses of Cash

The following table sets forth the Company’s major sources and uses of cash for each of the following periods:

Net cash used in operating activities
Net cash used in investing activities
Net cash provided by financing activities
Net increase (decrease) in cash

Year Ended
December 31,

  $

  $

2020

2019

(8,013,929)   $
(34,733)  
5,451,892   
(2,596,770)   $

(6,030,004)
(171,076)
16,645,634 
10,444,554 

51

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
Operating Activities

Net cash used in operating activities was $8,013,929 during the year ended December 31, 2020, versus $6,030,004 used during the comparable prior year
period. The increase in 2020 was due primarily to inventory purchases and higher insurance, professional services fees, consulting, and labor costs paid in
the current period.

Investing Activities

Net cash used in investing activities was $34,733 for the year ended December 31, 2020 and $171,076 for the year ended December 30, 2019. Cash was
used in both periods for the purchase of testing equipment, furniture and fixtures.

Financing Activities

Net cash provided by financing activities was $5,451,892 for the year ended December 31, 2020, and was due to warrant exercises during the period. Net
cash  provided  by  financing  activities  was  $9,236,167  for  the  year  ended  December  31,  2019  was  due  primarily  to  the  completion  of  our  IPO,  which
resulted  in  net  proceeds  of  $3,888,000.  In  addition,  in  March  2019,  the  Company  issued  $350,000  in  promissory  and  convertible  promissory  notes  and
received cash of $131,875 from the exercise of warrants. These proceeds were partially offset by payment of $100,000 to settle a promissory note.

On August 15, 2019, the Company completed a second public offering (the “August Offering”) of (i) 2,000,000 shares of common stock, (ii) pre-funded
warrants  exercisable  for  166,667  shares  of  common  stock  (the  “Pre-Funded  Warrants”),  and  (iii)  warrants  to  purchase  up  to  an  aggregate  of  2,166,667
shares of common stock (the “August Warrants”). The August Offering was conducted pursuant to an Underwriting Agreement, dated August 13, 2019 by
and between the Company and Maxim Group LLC and WallachBeth Capital, LLC. On August 16, 2019, the Company sold an additional 325,000 August
Warrants  upon  exercise  of  the  underwriters’  over-allotment  option.  The  net  proceeds  to  the  Company  from  the  August  Offering,  after  deducting
underwriting discounts and commissions and other estimated expenses were $4,944,340. 

The public offering price was $2.64 per share of common stock and $0.01 per accompanying August Warrant. Each August Warrant represents the right to
purchase one share of common stock at an exercise price of $3.51 per share. The August Warrants are exercisable immediately, expire five years from the
date of issuance and provide that, beginning on the earlier of (i) September 11, 2019 and (ii) the date on which the common stock traded an aggregate of
more than 6,666,667 shares after the announcement of the pricing of the August Offering, and ending on the twelve (12) month anniversary thereof, each
August Warrant may be exercised at the option of the holder on a cashless basis at a ratio of one August Warrant for one share of common stock, in whole
or in part, if the weighted average price of the Common Stock on the trading day immediately prior to the exercise date fails to exceed the initial exercise
price of the August Warrant.

On October 30, 2019, the Company completed a third public offering of 4,083,334 shares of its common stock (including 283,334 pre-funded warrants to
purchase common stock in lieu thereof) and Series B warrants to purchase up to 4,083,334 shares of the Company’s common stock. Each share of common
stock (or pre-funded warrant) was sold together with one Series B warrant to purchase one share of common stock at a combined price to the public of
$2.052 per share and Series B warrant. The shares of common stock or pre-funded warrants and the accompanying Series B warrants were sold together but
will be issued separately and will be immediately separable upon issuance. Net proceeds, after deducting underwriting discounts, commissions and offering
expenses, were approximately $7.4 million.

The  Series  B  warrants  are  exercisable  at  a  price  of  $2.052  per  share  of  common  stock  and  will  expire  five  years  from  the  date  on  which  the  Series  B
warrants become initially exercisable. On December 6, 2019, pursuant to shareholder approval, the Company filed a Certificate of Amendment to amends
its  Certificate  of  Incorporation  to  increase  its  authorized  shares  of  common  stock  to  250  million  shares.  Thus,  the  Company  has  a  sufficient  number  of
authorized shares of common stock to issue the shares of common stock issuable upon the exercise of the Series B warrants.

Off-Balance Sheet Arrangements

At  December  31,  2020  and  December  31,  2019,  the  Company  did  not  have  any  transactions,  obligations  or  relationships  that  could  be  considered  off-
balance sheet arrangements.

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK

Not applicable.

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The information required by this item may be found beginning on page F-1 of this Annual Report.

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

None.

ITEM 9A. CONTROLS AND PROCEDURES

(a)  Disclosure  Controls  and  Procedures.  Under  the  supervision  and  with  the  participation  of  our  senior  management,  consisting  of  our  Chief  Executive
Officer and Chief Financial Officer, we conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures
(as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), as of the end of the period
covered  by  this  report  (the  “Evaluation  Date”).  Based  on  that  evaluation,  the  Company’s  management  concluded  that  as  of  the  Evaluation  Date  our
disclosure controls and procedures were effective to ensure that information required to be disclosed by us in the reports that we file under the Exchange
Act is recorded, processed, summarized and reported within the time periods specified in SEC rules and forms. Our disclosure controls and procedures
include,  without  limitation,  controls  and  procedures  designed  to  ensure  that  information  required  to  be  disclosed  by  us  in  our  Exchange  Act  reports  is
accumulated and communicated to our management, including our chief executive officer and directors, as appropriate to allow timely decisions regarding
required disclosure.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
52

(b)  Management’s  Annual  Report  on  Internal  Control  Over  Financial  Reporting.  The  Company’s  management  is  responsible  for  establishing  and
maintaining an adequate system of internal control over financial reporting (as defined in Exchange Act Rule 13a-15(f)). Our internal control over financial
reporting  is  a  process,  under  the  supervision  of  our  Chief  Executive  Officer  and  Chief  Accounting  Officer,  designed  to  provide  reasonable  assurance
regarding  the  reliability  of  financial  reporting  and  the  preparation  of  financial  statements  for  external  purposes  in  accordance  with  generally  accepted
accounting principles in the United States. These internal controls over financial reporting processes include policies and procedures that:

a. Pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Company;

b.  Provide  reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit  preparation  of  financial  statements  in  accordance  with  generally
accepted accounting principles, and that receipts and expenditures of the Company are being made only in accordance with authorizations of management
and directors of the Company; and

c. Provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company’s assets that could
have a material effect on the financial statements.

Because  of  its  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect  misstatements.  Therefore,  even  those  systems
determined to be effective can provide only reasonable assurance of achieving their control objectives.

In evaluating the effectiveness of our internal control over financial reporting, our management used the criteria set forth by the Committee of Sponsoring
Organizations  of  the  Treadway  Commission  (COSO)  in  Internal  Control  -  Integrated  Framework  2013.  Based  on  this  evaluation,  our  Chief  Executive
Officer  and  our  Chief  Accounting  Officer  determined,  based  upon  the  existence  of  the  material  weakness  described  below,  that  we  did  not  maintain
effective internal control over financial reporting as of December 31, 2020.

Segregation  of  Duties  –  The  Company  did  not  maintain  effective  policies  to  ensure  adequate  segregation  of  duties  within  its  accounting  processes.
Specifically,  due  to  the  size  of  the  Company  and  the  smaller  nature  of  department  teams,  opportunities  are  limited  to  segregate  duties,  resulting  in  one
individual having almost complete responsibility for the processing of certain financial information.

While we have designed and implemented, or expect to implement, measures that we believe address or will address this control weakness, we continue to
develop  our  internal  controls,  processes  and  reporting  systems  by,  among  other  things,  hiring  qualified  personnel  with  expertise  to  perform  specific
functions, and designing and implementing improved processes and internal controls, including ongoing senior management review and audit committee
oversight. We plan to remediate the identified material weakness through the redistribution of job responsibilities, by hiring additional senior accounting
staff, and through the design and implementation of additional internal controls in order to promote adequate segregation of duties. We expect to complete
the remediation in 2021. We expect to incur additional costs to remediate this weakness, primarily personnel costs.

We may not be successful in implementing these changes or in developing other internal controls, which may undermine our ability to provide accurate,
timely and reliable reports on our financial and operating results. Further, we will not be able to fully assess whether the steps we are taking will remediate
the  material  weakness  in  our  internal  control  over  financial  reporting  until  we  have  completed  our  implementation  efforts  and  sufficient  time  passes  in
order to evaluate their effectiveness. In addition, if we identify additional material weaknesses in our internal control over financial reporting, we may not
detect errors on a timely basis and our financial statements may be materially misstated. Moreover, in the future we may engage in business transactions,
such as acquisitions, reorganizations or implementation of new information systems that could negatively affect our internal control over financial reporting
and result in material weaknesses.

This annual report does not include an attestation report of our registered public accounting firm regarding internal control over financial reporting.

Management’s  report  was  not  subject  to  attestation  by  our  registered  public  accounting  firm  pursuant  to  the  rules  of  the  Securities  and  Exchange
Commission that permit the Company to provide only management’s report in this annual report.

53

 
 
 
 
 
 
 
 
 
 
 
 
 
(c) Changes in Internal Control over Financial Reporting. There were no changes in our internal control over financial reporting identified in connection
with the evaluation required by paragraph (d) of Rule 13a-15 or Rule 15d-15 under the Exchange Act that occurred during or subsequent to the Company’s
last fiscal quarter of the period covered by this report that have materially affected, or are reasonably likely to materially affect, our internal control over
financial reporting.

ITEM 9B. OTHER INFORMATION

Not Applicable.

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

PART III

Set forth below is certain information regarding the Company’s current executive officers and directors based on information furnished to the Company by
each  executive  officer  and  director.  Each  of  the  directors  listed  below  was  elected  to  the  Board  of  Directors  to  serve  until  the  Company’s  next  annual
meeting of stockholders or until his or her successor is elected and qualified.

Name

Age

Position

Bret Scholtes

Robert Weingarten

Mark Goldstone

David W. Evans

Donald A. Gagliano

Kelly Anderson

Andrew Schmidt

Management Team

51

68

57

64

68

53

59

  President and Chief Executive Officer, and Director

  Chairman of the Board of Directors

  Director

  Director, Chief Science Officer

  Director

  Director

  Chief Financial Officer

Bret Scholtes has been Chief Executive Officer and a director since January 2021. Prior to his appointment, he served as the President and Chief Executive
Officer of Omega Protein Corporation (“Omega”) since 2012 and as a director of Omega since 2013. Prior to his selection as Chief Executive Officer of
Omega, Mr. Scholtes served as the Omega’s Senior Vice President-Corporate Development from April 2010 to December 2010 and as Omega’s Executive
Vice President and Chief Financial Officer from January 2011 to December 2011. From 2006 to April 2010, Mr. Scholtes served as a Vice President at GE
Energy  Financial  Services,  a  global  energy  investment  firm.  Prior  to  that,  Mr.  Scholtes  held  positions  with  two  publicly  traded  energy  companies.  Mr.
Scholtes also has five years of public accounting experience. Mr. Scholtes holds an MBA degree in Finance from New York University and a degree in
Accounting  from  the  University  of  Missouri  –  Columbia.  These  skills  and  experiences  make  Mr.  Scholtes  particularly  suitable  to  serve  as  our  Chief
Executive Officer and as a director of the Company.

Robert  N.  Weingarten  has  been  a  Director  of  the  Company  since  June  2015  and  Chairman  of  the  board  of  directors  since  July  2020.  Previously,  Mr.
Weingarten served as Lead Director on our board of directors from January 2017 to March 2020. He is an experienced business consultant and advisor with
an ongoing consulting practice. Since 1979, he has provided financial consulting and advisory services and served on boards of directors of several public
companies in various stages of development, operation or reorganization. From July 2017 to June 2018, Mr. Weingarten was the Chief Financial Officer of
Alltemp, Inc. From April 2013 to February 2017, Mr. Weingarten served on the board of directors of RespireRx Pharmaceuticals Inc. (OTCQB: RSPI) and
also served as Vice President and Chief Financial Officer. Mr. Weingarten received a B.A. in Accounting from the University of Washington in 1974, a
M.B.A. in Finance from the University of Southern California in 1975, and is a Certified Public Accountant (inactive) in the State of California. In August
2020, Mr. Weingarten was appointed as Vice President and Chief Financial Officer of Lixte Biotechnology Holdings, Inc., a company listed on The Nasdaq
Stock  Market.    Mr.  Weingarten  has  considerable  accounting  and  finance  experience,  particularly  with  regard  to  public  reporting  requirements.  The
Company believes that Mr. Weingarten’s accounting and finance experience qualifies him to serve on the board of directors.

54

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Mark Goldstone has been a Director since June 2015. Mr. Goldstone has over 25 years of leadership experience in the healthcare industry, encompassing
operations,  commercialization  consulting  and  venture  capital.  He  has  executed  numerous  M&A,  financing  and  strategic  partnership  transactions,  for  a
broad  array  of  middle  market  and  emerging  growth  companies  in  technology,  life  sciences  and  healthcare  services,  which  qualifies  him  to  serve  on  the
Board of Directors. From 2007 to 2013, Mr. Goldstone was the global President of DDB Worldwide Communications Group Inc.’s healthcare business,
where  he  was  responsible  for  a  global  communications  business  spanning  40+  offices  in  over  36  markets.  Mr.  Goldstone  has  previously  held  senior
positions at Publicis Healthcare Communications Group where he was responsible for the global Sanofi business and at Interbrand where he was CEO of
its global Healthcare business. 

Mr. Goldstone moved from the United Kingdom to New York with Havas Group, where from 1996 to 2003 he held senior positions at Robert A. Becker,
Euro RSCG and Jordan McGrath Case & Partners, Euro RSCG and ultimately at Euro RSCG Worldwide Headquarters, where he helped devise and build
their global healthcare business – Euro RSCG Life Worldwide (Now Havas Life). Mr. Goldstone holds a BSc (Hons) in Pharmacy. He is a board member
of the prestigious Galien Foundation, a member of the Royal Pharmaceutical Society of Great Britain and is a past Co-Chairman of New York Corporate
Development for the American Diabetes Association. Mr. Goldstone’s breadth of experience in sales, marketing and strategic transactions in the healthcare
industry  is  particularly  useful  to  the  Company  as  it  develops  its  business,  commercializes  products  and  builds  its  marketing  channels.  The  Company
believes  that  these  experiences  make  Mr.  Goldstone  particularly  suitable  to  serve  as  a  director  and  guide  the  Company  in  the  complexities  of  the  life
science and healthcare services industries.

Donald A.  Gagliano  has  served  as  a  Director  since  the  Company’s  initial  public  offering  on  April  9,  2019.  Dr.  Gagliano  had  been  a  member  of  our
Scientific  Advisory  Board  since  June  2015.  Since  October  2018,  Dr.  Gagliano  has  been  the  principal  of  GMIC  LLC,  which  provides  healthcare
consultation services primarily for health systems engineering and ophthalmology subject matter expertise. From April 2013 to October 2013, Dr. Gagliano
was the Vice President for Global Medical Affairs for Bausch+Lomb, Inc. From 2016 to present, Dr. Gagliano has served as the President of the Prevention
of  Blindness  Society.  From  November  2008  to  March  2013,  Dr.  Gagliano  served  as  the  Assistant  Secretary  of  Defense  for  Health  Affairs  as  the  first
Executive Director of the Joint Department of Defense (DoD) and Department of Veterans Affairs (VA) Vision Center of Excellence (VCE). In 1975, Dr.
Gagliano graduated from the US Military Academy at WestPoint with a degree in Engineering. In 1981, he received a Bachelor of Science in medicine
from  Chicago  Medical  School  and  in  1998  he  received  his  Master  of  Healthcare  Administration  from  Penn  State  University.  Dr.  Gagliano’s  breadth  of
experience in the healthcare industry is particularly useful to the Company as it develops its business, commercializes products and builds its marketing
channels.  The  Company  believes  that  these  experiences  make  Dr.  Gagliano  particularly  suitable  to  serve  as  a  director  and  guide  the  Company  in  the
complexities of the life science and healthcare services industries.

David W. Evans has been a Director since September 2017. Dr. Evans acted as interim chief executive officer of the Company from June 2020 to January
2021. Dr. Evans is the founder of VectorVision and serves as the Company’s Chief Science Officer. Dr. Evans is recognized as the leading expert in clinical
contrast sensitivity and glare testing. He has provided his testing expertise and data analysis capability to a wide range of leading ophthalmic companies.
Dr. Evans has published more than 30 scientific articles and 3 book chapters in the areas of refractive surgery, glaucoma, ocular blood flow and visual
function, and is the inventor of 5 patents related to vision testing devices. Dr. Evans received his Bachelor of Science degree in Human Factors Engineering
from the United States Air Force Academy, a Master of Science degree and Masters in Business Administration from Wright State University in Dayton,
Ohio, and a Ph.D. in Ocular Physiology from Indiana University. The Company believes that these experiences make Dr. Evans particularly suitable to
serve as a director and guide the Company in the complexities of the life science and healthcare services industries.

55

 
 
 
 
 
 
Kelly Anderson has over 25 years of experience in finance, accounting and operations roles in various industries. Since 2015, Ms. Anderson has been a
managing partner in C Suite Financial Partners, a financial consulting services company dedicated to serving private, public, private equity, entrepreneurial,
family office and government-owned firms in all industries. Between July 2014 and March 2015, Ms. Anderson was CFO of Mavenlink, a SaaS company.
Between October 2012 and January 2014, Ms. Anderson was Chief Accounting Officer of Fisker Automotive. Between April 2010 and February 2012, Ms.
Anderson  was  the  President  and  Chief  Financial  Officer  of  T3  Motion,  Inc.  (“T3”),  an  electric  vehicle  technology  company.  Between  March  2008  and
April 2010, she served as T3’s Executive Vice President and Chief Financial Officer, and as a director from January 2009 until January 2010. From 2006
until 2008, Ms. Anderson was Vice President at Experian, a leading credit reporting agency. From 2004 until 2006, Ms. Anderson was Chief Accounting
Officer  for  TripleNet  Properties  and  its  affiliates.  From  1996  to  2004,  Ms.  Anderson  held  senior  financial  positions  with  The  First  American  Corp.,  a
Fortune 500 title insurance company. Ms. Anderson has served on the board of directors for Tomi Environmental Services (OCTQB: TOMZ) since 2016
and Concierge Technologies since May 2019 (OTCQB: CNCG). Ms. Anderson is also a founder of CXO Executive Solutions, which is now a Hawkstone
Capital  Portfolio  Company.  Ms.  Anderson  is  a  CPA  (Inactive).  Ms.  Anderson  holds  a  B.A.  degree  in  Business  Administration  with  an  accounting
concentration from California State University Fullerton.

Andrew Schmidt has served as our Chief Financial Officer since July 20, 2020. Prior to his appointment with the Company, Mr. Schmidt served as Vice
President of Finance, Chief Financial Officer and Secretary of Iteris, Inc. (NASD: “ITI”), a publicly traded technology company from March 2015 through
December  2019.  Prior  to  joining  Iteris,  Mr.  Schmidt  served  as  the  Chief  Financial  Officer  and  Corporate  Secretary  of  Smith  Micro  Software,  Inc.,  a
publicly-held  provider  of  wireless  and  mobility  software  solutions  from  2005  to  May  2014.  Mr.  Schmidt  holds  a  B.B.A.  degree  in  Finance  from  the
University of Texas and an M.S. degree in Accountancy from San Diego State University.

Director or Officer Involvement in Certain Legal Proceedings

The  Company’s  directors  and  executive  officers  were  not  involved  in  any  legal  proceedings  described  in  Item  401(f)  of  Regulation  S-K  in  the  past  ten
years.

Family Relationships

There are no family relationships among any of our executive officers or directors.

Director Independence

The  listing  rules  of  NASDAQ  Capital  Market  require  that  independent  directors  must  comprise  a  majority  of  a  listed  company’s  board  of  directors.  In
addition, the rules of the NASDAQ Capital Market require that, subject to specified exceptions, each member of a listed company’s audit, compensation,
and nominating and governance committees be independent. Audit committee members must also satisfy the independence criteria set forth in Rule 10A-3
under the Exchange Act. Under the rules of the NASDAQ Capital Market, a director will only qualify as an “independent director” if, in the opinion of that
company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the
responsibilities of a director.

The Company’s Board of Directors has undertaken a review of the independence of the Company’s directors and director nominees and considered whether
any  director  has  a  material  relationship  with  it  that  could  compromise  his  or  her  ability  to  exercise  independent  judgment  in  carrying  out  his  or  her
responsibilities. Based upon information requested from and provided by each director concerning his background, employment and affiliations, including
family relationships, the Board of Directors has determined that as of December 31, 2020, each of Messrs. Weingarten, Goldstone, Gagliano and Anderson,
representing four (4) of the Company’s six (6) directors, are “independent” as that term is defined under the applicable rules and regulations of the SEC and
the listing standards of the NASDAQ Capital Market. In making these determinations, the Board of Directors considered the current and prior relationships
that each non-employee director has with the Company and all other facts and circumstances the Board of Directors deemed relevant in determining their
independence,  including  the  beneficial  ownership  of  the  Company’s  capital  stock  by  each  non-employee  director,  and  any  transactions  involving  them
described in the section captioned “—Certain Relationships and Related Transactions and Director Independence.”

56

 
 
 
 
 
 
 
 
 
 
 
Code of Business Conduct and Ethics

The Company’s board of directors adopted a code of business conduct and ethics applicable to its employees, directors and officers, in accordance with
applicable  U.S.  federal  securities  laws  and  the  corporate  governance  rules  of  the  Nasdaq  Capital  Market.  The  code  of  business  conduct  and  ethics  is
publicly  available  on  the  Company’s  website.  Any  substantive  amendments  or  waivers  of  the  code  of  business  conduct  and  ethics  or  code  of  ethics  for
senior  financial  officers  may  be  made  only  by  the  Company’s  board  of  directors  and  will  be  promptly  disclosed  as  required  by  applicable  U.S.  federal
securities laws and the corporate governance rules of the Nasdaq Capital Market.

ITEM 11. EXECUTIVE COMPENSATION

Summary Compensation Table

The  following  table  sets  forth  the  total  compensation  paid  or  accrued  during  the  fiscal  years  ended  December  31,  2020  and  2019  to  of  our  “Named
Executive Officers”.

Executive

Year

Salary    

Bonus

Stock 
Awards    

All Other
Compensation   

Total

Michael Favish (1)

David W. Evans (2)

John Townsend (3)

Andrew Schmidt (4)

  2020     $ 325,000    $
  2019     $ 300,000    $
  2020     $ 273,211    $
  2019     $ 210,000    $
  2020     $ 101,771    $
  2019     $ 185,000    $
  2020     $ 114,583    $
-    $
  2019     $

-    $
-    $
-    $ 4,122,750    $
22,204    $
-    $
-    $
-    $
-    $
-    $
-    $
25,000    $
66,512    $
-    $
-    $
-    $

32,197    $ 357,197 
38,972    $ 4,461,722 
-    $ 295,415 
-    $ 210,000 
6,146    $ 107,917 
4,031    $ 214,031 
-    $ 181,095 
- 
-    $

(1) Effective June 12, 2020, Michael Favish terminated as Chief Executive Officer and President of the Company and resigned as a member of the Board.
Mr. Favish was awarded a stock option grant on April 9, 2019 for 208,334 shares of the Company’s common stock at an exercise price of $26.40 per share
(110%  of  the  IPO  price  per  common  share)  pursuant  to  his  employment  agreement  (the  “Favish  Option”).  In  connection  with  the  termination  of
employment, the Company agreed to pay Mr. Favish a severance payment of $325,000, to be paid out over 12 months. Additionally, the Company agreed
that the Favish Option shall remain exercisable for a period of twelve (12) months from June 12, 2020 in lieu of the ninety (90) days provided for under the
terms of the original stock option agreement following the termination. The Favish Option ceased to vest upon his separation from the Company. All Other
Compensation for 2019 associated with Mr. Favish includes Company reimbursed personal meals, personal automobile expense, club membership fees,
health  care  related  expenses  that  fall  outside  of  the  Company  provided  health  insurance  plan  and  use  of  American  Express  membership  rewards  points
acquired under the Company’s corporate American Express card. Compensation for 2020 consists of cash-based compensation. All Other Compensation
for 2020 associated with Mr. Favish primarily includes payout of accrued vacation upon his termination. Due to Mr. Favish’s separation, an accrual was
recorded in the Company’s fiscal second quarter ended June 30, 2020 of $311.458 as balance due of salary compensation expense and a reversal related to
forfeited fully expensed stock option awards of $1,401,582.

(2) Dr. Evans acted as interim chief executive officer of the Company from June 12, 2020 to January 6, 2021. The Company entered into a Consulting
Agreement with Dr. Evans, dated as of September 29, 2017 (as amended, the “Evans Consulting Agreement”). The Evans Consulting Agreement provided
that Dr. Evans would serve as the Company’s Chief Science Officer and is currently being paid $17,500 per month as an employee of the Company. The
Company  and  Dr.  Evans  entered  into  an  amendment  to  the  Evans  Consulting  Agreement,  which  amendment,  effective  as  of  June  12,  2020,  (1)
acknowledged  his  appointment  as  Interim  Chief  Executive  Officer  and  Interim  President  and  (2)  increased  his  compensation  by  Ten  Thousand  Dollars
($10,000) per month for each month that he remains Interim Chief Executive Officer and Interim President.

(3) Effective as of September 2, 2020, John Townsend resigned as the Controller and Chief Accounting Officer of the Company. All Other Compensation
associated with Mr. Townsend includes Company reimbursed personal meals and personal automobile expense.

(4)  Effective  July  20,  2020,  Mr.  Schmidt  was  appointed  as  Chief  Financial  Officer  of  the  Company.  The  Company  and  Mr.  Schmidt  entered  into  an
employment agreement (the “Employment Agreement”), dated July 20, 2020 (the “Effective Date”), pursuant to which Mr. Schmidt’s annual base salary is
$250,000. In addition, effective as of the Effective Date, Mr. Schmidt was granted an award of 166,667 stock options under the Company’s 2018 Equity
Incentive Plan, at an exercise price of six dollars ($6.00) per share.

57

 
 
 
 
 
 
 
 
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Employment Agreements

Bret Scholtes

The  Company  and  Mr.  Scholtes  entered  into  an  employment  agreement  (the  “Scholtes  Employment  Agreement”),  effective  on  January  6,  2021  (the
“Effective Date”), pursuant to which Mr. Scholtes’ annual base salary is $400,000. The Scholtes Employment Agreement provides that Mr. Scholtes shall
have an annual target cash bonus opportunity of no less than $400,000 (the “Bonus”) based on the achievement of Company and individual performance
objectives to be determined in good faith by the Board in advance and in consultation with Mr. Scholtes (the “Performance Objectives”). The initial term of
the Scholtes Employment Agreement is through December 31, 2023, with automatic one-year renewals, unless either party provides written notice of a
non-renewal  in  accordance  with  the  terms  of  the  Scholtes  Employment  Agreement  (the  “Term”).  The  Scholtes  Employment  Agreement  also  includes
standard benefits, as well as customary non-compete, non-solicitation, intellectual property assignment and confidentiality provisions that are customary in
the Company’s industry.

In addition, effective as of the Effective Date, Mr. Scholtes shall be granted an award of a number of stock options equal to one percent (1%) of the issued
and  outstanding  number  of  shares  of  the  Company’s  common  stock  (the  “Stock  Options”)  pursuant  to  the  Company’s  2018  Equity  Incentive  Plan  (the
“Incentive  Plan”),  at  an  exercise  price  equal  to  the  closing  price  of  the  Company’s  common  stock  on  the  Effective  Date.  One  third  (1/3)  of  the  Stock
Options  shall  vest  and  become  exercisable  the  first  anniversary  of  the  Effective  Date,  and  the  balance  of  the  Stock  Options  shall  vest  ratably  in  equal
installments  for  the  twenty-four  (24)  months  thereafter,  subject  to  continued  service,  and  shall  vest  in  full  upon  a  Change  in  Control  (as  defined  in  the
Incentive Plan). Additionally, the Company shall grant unvested shares of common stock in an amount equal to one percent (1%) of the number of shares
of  Company  common  stock  issued  and  outstanding  on  the  Effective  Date  (the  “Stock  Grant”)  to  Mr.  Scholtes  under  the  Incentive  Plan.  The  shares
underlying the Stock Grant shall become vested in full on the first anniversary of the Effective Date.

Additionally,  Mr.  Scholtes  shall  be  granted  (i)  additional  stock  options  equal  to  two  percent  (2%)  of  the  Company’s  issued  and  outstanding  shares  of
common stock on the date of grant if the Company achieves specified written performance objectives established by the Board for the Company’s fiscal
years ending December 31, 2021 and December 31, 2022 and (ii) additional stock options equal to either two percent (2%) or three percent (3%) of the
Company’s issued and outstanding shares of common stock on the date of grant if the Company meets certain financial objectives during the first five years
following the Effective Date.

If Mr. Scholtes’s employment is terminated by the Company without cause (as defined in the Scholtes Employment Agreement), if the Term expires after a
notice of non-renewal is delivered by the Company or if Mr. Scholtes’s employment is terminated following a change of control (as defined in the Incentive
Plan), Mr. Scholtes will be entitled to (a) twelve months’ base salary, (b) the prorated portion of the Bonus for the year in which the termination occurs,
based on actual performance and (c) base salary and benefits accrued through the date of termination.

David Evans

The Company entered into a Consulting Agreement with Dr. Evans, dated as of September 29, 2017 (as amended, the “Evans Consulting Agreement”). The
Evans Consulting Agreement provided that Dr. Evans would serve as the Company’s Chief Science Officer and is currently being paid $17,500 per month
as an employee of the Company. The Company and Dr. Evans entered into an amendment to the Evans Consulting Agreement, which amendment, effective
as of June 12, 2020, (1) acknowledged his appointment as Interim Chief Executive Officer and Interim President and (2) increased his compensation by Ten
Thousand Dollars ($10,000) per month for each month that he remained Interim Chief Executive Officer and Interim President.

58

 
 
 
 
 
 
 
 
 
 
Andrew C. Schmidt

The  Company  and  Mr.  Schmidt  entered  into  an  employment  agreement  (the  “Employment  Agreement”),  dated  July  20,  2020  (the  “Effective  Date”),
pursuant to which Mr. Schmidt’s annual base salary is $250,000. The Employment Agreement provides that Mr. Schmidt shall have an annual target cash
bonus opportunity of no less than $175,000 (the “Bonus”) based on the achievement of Company and individual performance objectives to be determined
in  good  faith  by  the  Board  in  advance  and  in  consultation  with  Mr.  Schmidt  (the  “Performance  Objectives”),  provided,  however,  that  the  parties
acknowledged and agreed that up to an aggregate of $100,000 of the Bonus shall be payable upon the closing(s) of one or more mergers and acquisition
transactions as determined at the discretion of the Board, and $75,000 shall be based upon the satisfactory completion of the Performance Objectives. The
initial term of the Employment Agreement is through July 20, 2021, with automatic one-year renewals, unless either party provides written notice of a non-
renewal in accordance with the terms of the Employment Agreement (the “Term”).

Mr. Schmidt is also entitled to certain other benefits consistent with those provided to other senior executives of the Company. In addition, effective as of
the Effective Date, Mr. Schmidt shall be granted an award of 166,667 stock options (the “Stock Options”) under the Company’s 2018 Equity Incentive Plan
(the  “Incentive  Plan”),  at  an  exercise  price  of  six  dollars  ($6.00)  per  share.  The  Stock  Options  shall  vest  and  become  exercisable  in  twelve  (12)  equal
installments on the last day of each of the subsequent twelve (12) calendar quarter-end dates following the Effective Date (the first of such dates to be
September 30, 2020), subject to continued service, and shall vest in full upon a Change in Control (as defined in the Incentive Plan). The Sock Options
granted shall be subject, to the extent necessary, to the approval of the Company’s stockholders of a proposal to increase the authorized number of shares
available under the Incentive Plan.

If Mr. Schmidt’s employment is terminated by the Company without cause (as defined in the Employment Agreement), if the Term expires after a notice of
non-renewal is delivered by the Company or if Mr. Schmidt’s employment is terminated following a change of control (as defined in the Incentive Plan),
Mr. Schmidt will be entitled to (a) six months’ base salary, (b) the prorated portion of the Bonus for the year in which the termination occurs, based on
actual performance and (c) base salary and benefits accrued through the date of termination.

Outstanding Equity Awards at Fiscal Year-End

The following table sets forth information regarding outstanding stock options held by our named executive officers as of December 31, 2020:

NAME

Michael Favish
David W. Evans
John Townsend
Andrew Schmidt

GRANT 

DATE    

VESTING
COMMENCEMENT
DATE

NUMBER OF
SECURITIES
UNDERLYING
UNEXERCISED
OPTIONS
EXERCISABLE
(#)

NUMBER OF
SECURITIES
UNDERLYING
UNEXERCISED
OPTIONS
UNEXERCISABLE
(#)

OPTION
EXERCISE
PRICE
($)

OPTION
EXPIRATION
DATE

  4/9/2019   
  6/30/2020   
-   
  7/20/2020   

4/9/2019   
6/30/2020   
-   
7/20/2020   

59

69,445   
4,167   
-   
24,962   

-    $

12,500   
-   
141,705   

26.40   
6.00   
-   
6.00   

6/12/2021
6/30/2030 
- 
7/20/2030 

 
 
 
 
 
 
 
 
 
   
   
   
   
 
 
 
 
   
 
   
 
   
 
   
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Director Compensation

The Company accrued or paid compensation to its directors for serving in such capacity, as show in the table below.

Director

Mark Goldstone (1)

Robert Weingarten (2)

David W. Evans

Michael Favish

Donald A. Gagliano (3)

Kelly Anderson (4)

Year
2020
2019
2020
2019
2020
2019
2020
2019
2020
2019
2020
2019

Stock 
Awards

Fees Earned or
Paid in Cash    

Total

80,494    $
-    $
80,494    $
-    $
22,204    $
-    $
-    $
-    $
23,963    $
-    $
80,494    $
-    $

60,000    $
-    $
90,500    $
60,000    $
-    $
-    $
-    $
-    $
20,000    $
-    $
55,500    $
-    $

140,494 
- 
170,994 
60,000 
22,204 
- 
- 
- 
43,963 
- 
135,994 
- 

$
$
$
$
$
$
$
$
$
$
$
$

(1)  Mr.  Goldstone  earned  $60,000  during  2020  as  compensation  for  services  as  a  member  of  the  Board  of  Directors,  member  of  the  Audit  Committee,
Chairman of the Strategy Committee and Chairman of the Compensation Committee, of which $37,500 was paid in 2020, and $22,500 paid in 2021.

(2) Mr. Weingarten earned $100,500 as compensation for services as Chairman of the Board, Chairman of the Audit Committee, member of the Strategy
Committee, and member of the Compensation Committee, of which $68,375 was paid in 2020, and $32,125 paid in 2021.

(3) Mr. Gagliano earned $20,000 as compensation for services as a member of the Board of Directors, of which $15,000 was paid in 2020, and $5,000 paid
in 2021.

(4)  Ms.  Anderson  earned  $55,500  during  2020  as  compensation  for  services  as  a  member  of  the  Board  of  Directors,  member  of  the  Audit  Committee,
member of the Strategy Committee and member of the Compensation Committee, of which $34,625 was paid in 2020, and $20,875 paid in 2021.

On December 5, 2019, the board of directors adopted a director compensation program for the Company’s independent directors consisting of both cash
and  equity  compensation,  beginning  in  2020,  and  in  July  2020,  the  board  of  directors  adopted  a  director  compensation  program  for  the  Company’s
independent directors consisting of both cash and equity compensation for service on the newly formed Strategy Committee . The programs consist of the
following compensation for directors:

Cash Compensation (payable quarterly)

●  Board service - $20,000 per year
●  Chairman of the Board - $60,000 per year (inclusive of the Board service compensation)
●  Chairman of the Audit Committee – additional $10,000 per year
●  Chairman of the Compensation Committee – additional $5,000 per year
●  Chairman of the Strategy Committee – additional $40,000 per year, plus $1,000 per formal meeting held
●  Member of the Audit Committee – additional $5,000 per year
●  Member of the Compensation Committee – additional $2,500 per year
●  Member of the Strategy Committee – additional $36,000 per year, plus $1,000 per formal meeting held
●  Chairman of the Science Committee – additional $7,500 per year (established in February 2021)

Equity Compensation

●  Initial grant  for  new  director  –  five  year  stock  option  to  purchase  41,667  shares  of  Company  common  stock  at  the  closing  price of the Company’s
common stock on the grant date, vesting 50% on the grant date and the remainder vesting 12.5% on the last day of each subsequent calendar quarter-
end until fully vested, subject to continued service.

●  Annual grant – five year stock option to purchase 16,667 shares of Company common stock granted on the earlier of the date of the Company’s annual
meeting of stockholders or the last business day of the month ending June 30, vesting 12.5% on the last day of each subsequent calendar quarter-end
until fully vested, subject to continued service.

●  Strategy Committee – five year stock option to purchase 41,667 shares of Company common stock at $6.00 per share, vesting 50% on the grant date

and the remainder vesting 12.5% on the last day of each subsequent calendar quarter-end until fully vested, subject to continued service.

For 2020 stock option awards issued to Strategy Committee members were issued at $6.00 per share which was priced above the existing market price
at the date of stock option issuance.

60

 
 
 
 
 
   
   
 
 
 
   
 
 
 
   
 
 
   
 
 
 
   
 
 
   
 
 
 
   
 
 
   
 
 
 
   
 
 
   
 
 
 
   
 
 
   
 
 
 
   
 
 
 
 
 
 
 
 
 
  
  
 
 
ITEM  12.  SECURITY  OWNERSHIP  OF  CERTAIN  BENEFICIAL  OWNERS  AND  MANAGEMENT  AND  RELATED  STOCKHOLDER
MATTERS

The following table sets forth certain information regarding our common stock, beneficially owned as of March 25, 2021 by (i) each person known to us to
beneficially own more than 5% of our common stock, (ii) each executive officer and director, and (iii) all officers and directors as a group. The following
table  is  based  on  the  Company  having  24,426,993  as  of  March  25,  2021.  shares  of  common  stock  issued  and  outstanding  as  of  March  25,  2021.  We
calculated beneficial ownership according to Rule 13d-3 of the Securities Exchange Act of 1934, as amended as of that date. Shares of our common stock
issuable upon exercise of options or warrants or conversion of notes that are exercisable or convertible within 60 days after March 25, 2021 are included as
beneficially owned by the holder, but not deemed outstanding for computing the percentage of any other stockholder for Percentage of Common Stock
Beneficially  Owned.  For  each  individual  and  group  included  in  the  table  below,  percentage  ownership  is  calculated  by  dividing  the  number  of  shares
beneficially owned by such person or group by the sum of the 24,426,993 shares of common stock outstanding at March 25, 2021, plus the number of
shares  of  common  stock  that  such  person  or  group  had  the  right  to  acquire  on  or  within  60  days  after  March  25,  2021.  Beneficial  ownership  generally
includes voting and dispositive power with respect to securities. Unless otherwise indicated below, the persons and entities named in the table have sole
voting  and  sole  dispositive  power  with  respect  to  all  shares  beneficially  owned.  Unless  otherwise  indicated,  the  address  for  each  person  listed  is:  c/o
Guardion Health Sciences, Inc., 15150 Avenue of Science, Suite 200, San Diego, CA 92128.

Name of Beneficial Owner and Title of Officers and Directors

Beneficially Owned    

Percentage

Shares of
Common Stock

Bret Scholtes, Chief Executive Officer and Director (1)
Robert N. Weingarten, Chairman of the Board of Directors (2)
Mark Goldstone, Director
Donald A. Gagliano, Director
David Evans, Director (a)
Kelly Anderson, Director
Andrew Schmidt, Chief Financial Officer
All Officers and Directors as a Group (7 persons)

* Less than 1%.

322,154   
143,646   
122,446   
29,000   
264,000   
76,563   
38,661   
996,470   

1.3%
*%
*%
*%
1.1%
*%
*%
4.1%

(1) Includes (i) 169,484 shares of common stock held by Mr. Scholtes; and (ii) 152,671 restricted common stock units.

(2) Includes (i) 108,750 shares of common stock held by Mr. Weingarten; and (ii) 34,896 options to purchase common stock that will vest within 60 days

of the Filing Date held by Mr. Weingarten.

(3) Includes (i) 87,550 shares of common stock held by Mr. Goldstone; and (ii) 34,896 options to purchase common stock that will vest within 60 days of

the Filing Date held by Mr. Goldstone.

(4) Includes (i) 22,750 shares of common stock held by Mr. Gagliano; and (ii) 6,250 options to purchase common stock that will vest within 60 days of the

Filing Date held by Mr. Gagliano.

(5) Includes (i) 228,500 shares of common stock issued on September 29, 2017 in connection with the 2017 acquisition of VectorVision, Inc.; (ii)1,084
shares of common stock purchased April 9, 2019 in the Company’s initial public offering, which shares were registered on the registration statement
on Form S-1 that the SEC declared effective on April 4, 2019; (iii) 6,667 shares purchased in the Company’s August 2019 follow-on public offering;
(iv) 334 shares purchased in the Company’s October 2019 follow-on public offering; (v) 20,834 of the shares issued in exchange for the VectorVision,
Inc. acquisition that also serve as security for VectorVision, Inc.’s indemnification obligations under the related Asset Purchase Agreement; (vi) 334
Series B warrants to purchase common stock held by Dr. Evans; and (vii) 6,250 options to purchase common stock that will vest within 60 days of the
Record Date held by Dr. Evans.

(6) Includes 76,563 options to purchase common stock that will vest within 60 days of the Filing Date held by Ms. Anderson.

(7) Includes 38,661 options to purchase common stock that will vest within 60 days of the Filing Date held by Mr. Schmidt.

61

 
 
 
 
 
 
 
 
    
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ITEM 13. CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS AND DIRECTOR INDEPENDENCE

Except as set forth below, during the past three years, there have been no transactions, whether directly or indirectly, between the Company and any of its
officers, directors or their family members.

During  the  years  ended  December  31,  2020,  2019  and  2018,  the  Company  incurred  and  paid  $325,000,  $300,000  and  $275,000,  respectively,  of  salary
expense to our former Board Chairman and CEO, Mr. Michael Favish. In addition, compensation cost of $2,339,560 was recognized on amortization of
stock option awards during the year ended December 31, 2019. During the years ended December 31, 2020, 2019 and 2018, the Company incurred and
paid salaries of $75,000, $114,000 and $103,000, respectively, to Karen Favish, spouse of Michael Favish. During the year ended December 31, 2020, 2019
and 2018, the Company incurred and paid salaries of $60,000, $55,000 and $33,000, respectively, to Kristine Townsend, spouse of our former Controller
and Chief Accounting Officer John Townsend.

On  September  29,  2017,  the  Company  completed  the  acquisition  of  substantially  all  of  the  assets  and  liabilities  of  VectorVision  Ohio  in  exchange  for
254,167 shares of the Company’s common stock, pursuant to the Asset Purchase and Reorganization Agreement (“Asset Purchase Agreement”), which was
entered into on an arm’s-length basis. David W. Evans, a Director of the Company, owned 28% of the issued and outstanding shares of VectorVision Ohio
and his wife, Tamara Evans, owned 72% of the issued and outstanding shares of VectorVision Ohio. VectorVision Ocular Health, Inc is a wholly owned
subsidiary of the Company formed by the Company in connection with the acquisition of assets from VectorVision Ohio. Dr. Evans was appointed as a
director of the Company on September 29, 2017 pursuant to the Asset Purchase Agreement. The Company entered into a Consulting Agreement with Dr.
Evans, dated as of September 29, 2017 (the “Consulting Agreement”), whereby Dr. Evans has been engaged to serve as a consultant to the Company to
further the Company’s planned development and commercialization of the Company’s portfolio of products and technology. The Consulting Agreement has
an initial term of 3 years, with automatic one-year renewals unless earlier terminated. Dr. Evans is entitled to compensation of $10,000 per month for the
first six months of the term of the Consulting Agreement and $7,500 per month for the remainder of the term of the Consulting Agreement. Additionally,
on the same date, the Company and Dr. Evans entered into an Intellectual Property Purchase Agreement wherein the Company agreed to pay to Dr. Evans a
commercially  reasonable  royalty  payments  on  sales  of  goods  relating  to  vision  acuity  testing  during  the  term  of  the  agreement.  The  Company  and  Dr.
Evans entered into an amendment to the Consulting Agreement, which amendment, effective as of June 12, 2020, (1) acknowledged his appointment as
Interim Chief Executive Officer and Interim President and (2) increased his compensation by Ten Thousand Dollars ($10,000) per month for each month
that he remains Interim Chief Executive Officer and Interim President.

62

 
 
 
 
 
 
Dr.  Evans,  together  with  his  spouse,  wholly  owns  Ceatus  Media  Group  LLC,  a  California  limited  liability  company  (“Ceatus”),  founded  in  2004
specializing  in  digital  marketing  in  the  eye  health  care  sector.  The  Company  paid  Ceatus  $55,000  in  2018,  $81,000  in  2019  and  $95,750  in  2020,  for
services related to digital marketing for the Company.

Dr. Evans, together with his spouse, wholly owns DWT Evans LLC, an Ohio limited liability company (“DWT”), founded in 2000 which holds several
pieces of real estate. One of these holdings includes real property in Greenville, Ohio where the Company’s subsidiary, VectorVision Ocular Health, leases
office and warehouse space. The Company paid DWT rent in the amounts of $19,770 and $20,898 in 2020 and 2019, respectively.

When  the  Company  acquired  VectorVision,  it  also  acquired  AcQviz  from  Dr.  Evans,  which  is  a  patented  methodology  for  auto-calibrating  and
standardizing the testing light level for computer generated vision testing systems. Dr. Evans is entitled to receive a royalty on net revenue from AcQviz.
As part of the development of the CSV-2000, AcQviz was embedded in the product by Radiant Technologies, Inc. in exchange for a 3% royalty on the sales
of AcQviz. Radiant Technologies is owned by Joseph T. Evans, the brother of Dr. David Evans.

ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES

Weinberg & Company, P.A. acted as the Company’s independent registered public accounting firm for the years ended December 31, 2020 and 2019 and
for the interim periods in such fiscal years. The following table shows the fees that were incurred by the Company for audit and other services provided by
Weinberg & Company, P.A. for the years ended December 31, 2020 and 2019.

Audit Fees (a)
Tax Fees (b)
Other Fees (c)
Total

Year Ended December 31,

2020

2019

$

$

95,500    $
39,200   
120,500   
255,200    $

92,467 
31,818 
240,093 
364,378 

(a) Audit fees  represent  fees  for  professional  services  provided  in  connection  with  the  audit  of  the  Company’s  annual  financial  statements and the
review  of  its  financial  statements  included  in  the  Company’s  Quarterly  Reports  on  Form  10-Q  and  services  that  are  normally  provided  in
connection with statutory or regulatory filings.

(b) Tax fees represent fees for professional services related to tax compliance, tax advice and tax planning.

(c) Other fees represent fees related to our filing of certain Registration Statements.

All audit related services, tax services and other services rendered by Weinberg & Company, P.A. were pre-approved by the Company’s Board of Directors.
The Board of Directors has adopted a pre-approval policy that provides for the pre-approval of all services performed for the Company by its independent
registered public accounting firm. Our independent registered public accounting firm and management are required to periodically report to the Board of
Directors regarding the extent of services provided by the independent registered public accounting firm in accordance with this pre-approval, and the fees
for the services performed to date.

63

 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

(a)

list of documents filed as part of this report:

(1)

Financial Statements

PART IV

Reference is made to the Index to Financial Statements on page F-1, where these documents are listed.

(2)

Financial Statement Schedules

The  financial  statement  schedules  have  been  omitted  because  the  required  information  is  not  applicable,  or  not  present  in  amounts  sufficient  to  require
submission of the schedules, or because the information is included in the financial statements or notes thereto.

(3)

Exhibits

(b)

Exhibits:

A list of exhibits required to be filed as part of this Annual Report on Form 10-K is set forth in the Index to Exhibits, which is presented elsewhere in this
document, and is incorporated herein by reference.

64

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guardion Health Sciences, Inc.
Consolidated Financial Statements
Index

Report of Independent Registered Public Accounting Firm

Consolidated Financial Statements

Consolidated Balance Sheets – As of December 31, 2020 and 2019

Consolidated Statements of Operations – For the Years Ended December 31, 2020 and 2019

Consolidated Statements of Stockholders’ Equity – For the Years Ended December 31, 2020 and 2019

Consolidated Statements of Cash Flows – For the Years Ended December 31, 2020 and 2019

Notes to Consolidated Financial Statements

F-1

F-2

F-3

F-4

F-5

F-6

F-7

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Stockholders and Board of Directors of Guardion Health Sciences, Inc.
San Diego, California

Opinion on the Financial Statements

We have audited the accompanying consolidated balance sheets of Guardion Health Sciences, Inc. (the “Company”) as of December 31, 2020 and 2019, the
related consolidated statements of operations, stockholders’ equity, and cash flows for the years then ended, and the related notes (collectively referred to as
the  “consolidated  financial  statements”).  In  our  opinion,  the  consolidated  financial  statements  present  fairly,  in  all  material  respects,  the  consolidated
financial position of the Company as of December 31, 2020 and 2019, and the consolidated results of its operations and its cash flows for the years then
ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s
consolidated financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board
(United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the
applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable
assurance  about  whether  the  consolidated  financial  statements  are  free  of  material  misstatement,  whether  due  to  error  or  fraud.  The  Company  is  not
required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an
understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal
control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or
fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and
disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management,
as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

We have served as the Company’s auditor since 2015.

/s/ Weinberg & Company, P.A.

Los Angeles, California
March 26, 2021

F-2

 
 
 
 
 
 
 
 
 
 
 
 
 
Guardion Health Sciences, Inc.

Consolidated Balance Sheets

$

$

$

December 31,

2020

2019

8,518,732    $
11,248   
384,972   
179,931   

11,115,502 
78,337 
310,941 
362,938 

9,094,883   

11,867,718 

11,751   
285,676   
418,590   
50,000   

11,751 
374,638 
572,714 
50,000 

9,860,900    $

12,876,821 

608,313    $
127,637   
148,958   
25,978   
162,845   

1,073,731   

271,903   

1,345,634   

129,132 
116,211 
- 
13,323 
151,568 

410,234 

434,747 

844,981 

Assets

Current assets

Cash
Accounts receivable
Inventories
Prepaid expenses

Total current assets

Deposits
Property and equipment, net
Operating lease right-of-use asset, net
Intangible assets, net

Total assets

Liabilities and Stockholders’ Equity

Current liabilities

Accounts payable and accrued liabilities
Accrued expenses
Payable to former officer
Derivative warrant liability
Operating lease liability - current

Total current liabilities

Operating lease liability – long-term

Total liabilities

Commitments and contingencies

Stockholders’ Equity

Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued and outstanding
at December 31, 2020 and December 31, 2019
Common stock, $0.001 par value; 250,000,000 shares authorized; 15,170,628 and 12,497,094
shares issued and outstanding at December 31, 2020 and December 31, 2019
Additional paid-in capital
Accumulated deficit

Total stockholders’ equity

-   

- 

15,171   
62,583,423   
(54,083,328)  

12,497 
57,531,014 
(45,511,671)

8,515,266   

12,031,840 

Total liabilities and stockholders’ equity

$

9,860,900    $

12,876,821 

See accompanying notes to consolidated financial statements.

F-3

 
 
 
 
 
 
 
 
 
   
 
 
 
 
   
 
 
 
 
    
 
  
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
    
 
  
 
 
    
 
  
 
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
Guardion Health Sciences, Inc.

Consolidated Statements of Operations

Years Ended December 31,

2020

2019

Revenue

Medical foods
Medical devices
Other

Total revenue

Cost of goods sold

Medical foods (includes inventory write-down of $760,488 during the year ended December 31,
2020)
Medical devices (includes inventory write-down of $211,231 during the year ended December
31, 2020)
Other

Total cost of goods sold

Gross profit (loss)

Operating expenses

Research and development
Sales and marketing
General and administrative
Costs related to resignation of former officer (including the reversal of previously recognized
stock compensation expense of $965,295 during the year ended December 31, 2020)
Loss on sales of equipment
Equipment impairment
Goodwill impairment

Total operating expenses

Loss from operations

Other income (expenses):

Interest expense
Finance cost upon issuance of warrants
Change in fair value of derivative liability

Total other income (expenses)

Net loss

Net loss per common share – basic and diluted
Weighted average common shares outstanding – basic and diluted

$

1,609,482    $
275,862   
4,500   
1,889,844   

1,599,510   

344,647   
2,478   
1,946,635   

(56,791)  

160,978   
1,450,205   
7,450,245   

(615,936)  
18,500   
30,948   
-   

444,657 
434,010 
24,270 
902,937 

155.212 

178,815 
7,288 
341,315 

561,622 

194,311 
1,874,901 
7,425,827 

- 
- 
- 
1,563,520 

8,494,940   

11,058,559 

(8,551,731)  

(10,496,937)

(7,271)  
-   
(12,655)  

(19,926)  

(258,365)
(415,955)
292,949 

(381,371)

(8,571,657)  

(10,878,308)

$

(0.60)   $

14,256,856   

(1.79)
6,078,014 

See accompanying notes to consolidated financial statements.

F-4

 
 
 
 
 
 
 
 
 
   
 
 
 
 
   
 
 
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
Guardion Health Sciences, Inc.

Consolidated Statements of Stockholders’ Equity

Balance at December 31, 2018
Fair value of vested stock options – officer and
director
Fair value of vested stock options
Reclass of warrant liability to equity
Sale of common stock
Issuance of common stock for services
Issuance of common stock – warrant exercises
Fair value of common stock – conversion of notes
payable and related interest
Net loss
Balance at December 31, 2019
Reversal of previously recognized stock
compensation expense – former officer
Fair value of vested stock options
Issuance of common stock for services
Issuance of common stock – warrant exercises
Net loss
Balance at December 31, 2020

Common Stock

Shares

Amount

3,427,388    $

3,427    $

-     
-     
-     
6,008,333     
9,065     
3,034,135     

18,173     
-     
12,497,094     

-     
-     
16,667     
2,656,867     
-     
15,170,628    $

-     
-     
-     
6,008     
10     
3,034     

18     
-     
12,497     

-     
-     
17     
2,657     
-     
15,171    $

Additional
Paid-In
Capital
37,815,699    $

    Accumulated    
Deficit
(34,633,363)   $

Total
Stockholders’  
Equity

2,339,560     
254,170     
359,683     
16,218,799     
123,992     
168,341     

-     
-     
-     
-     
-     
-     

3,185,763 

2,339,560 
254,170 
359,683 
16,224,807 
124,002 
171,375 

250,770     
-     
57,531,014     

-     
(10,878,308)    
(45,511,671)    

250,788 
(10,878,308)
12,031,840 

(940,936)    
494,677     
49,433     
5,449,235     
-     
62,583,423    $

-     
-     
-     
-     
(8,571,657)    
(54,083,328)   $

(940,936)
494,677 
49,450 
5,451,892 
(8,571,657)
8,515,266 

See accompanying notes to consolidated financial statements.

F-5

 
 
 
 
 
 
   
 
 
   
   
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guardion Health Sciences, Inc.

Consolidated Statements of Cash Flows

Operating Activities

Net loss
Adjustments to reconcile net loss to net cash used in operating activities:

Depreciation and amortization
Impairment loss on equipment
Loss on sale of equipment
Inventory write-down
Goodwill impairment
Amortization of debt discount
Accrued interest expense included in notes payable
Amortization of operating lease right of use asset
Stock-based compensation
Stock-based compensation – former officer
Reversal of previously recognized stock compensation expense–former officer
Finance cost upon issuance of warrants
Change in fair value of derivative liability

Changes in operating assets and liabilities:

(Increase) / decrease:
Accounts receivable
Inventories
Deposits and prepaid expenses
Increase / (decrease):
Accounts payable and accrued expenses
Operating lease liability
Accrued expenses
Payable to former officer

Net cash used in operating activities

Investing Activities

Purchase of property and equipment
Proceeds from sales of equipment

Net cash used in investing activities

Financing Activities

Proceeds from initial public offering
Proceeds from follow-on public offerings
Proceeds from issuance of convertible notes
Proceeds from issuance of promissory note
Payments on promissory note
Proceeds from exercise of warrants

Net cash provided by financing activities

Cash:
Net increase (decrease)
Balance at beginning of period
Balance at end of period

Supplemental disclosure of cash flow information:

Cash paid for -
Interest
Income taxes

Non-cash financing activities:

Fair value of warrant liability in connection with issuance of convertible notes
Recording of lease asset and liability
Reclassification of prepaid costs to inventory
Reclassification of property and equipment to inventory
Reclassification of warrant liability to equity
Fair value of common stock issued upon conversion of convertible notes and accrued
interest
Reclass of deferred offering costs to equity

Years Ended December 31,

2020

2019

$

(8,571,657)   $

(10,878,308)

65,476   
30,948   
18,500   
971,719   
-   
-   
-   
154,124   
544,127   
-   
(940,936)  
-   
12,655   

67,089   
(728,801)  
(125,171)  

479,181   
(151,567)  
11,426   
148,958   

477,346 
- 
- 
- 
1,563,520 
250,000 
788 
148,440 
378,172 
2,339,560 
- 
415,955 
(292,949)

(50,135)
47,056 
(315,165)

(14,244)
(140,888)
40,848 
- 

(8,013,929)  

(6,030,004)

(40,733)  
6,000   

(34,733)  

-   
-   
-   
-   
-   
5,451,892   

5,451,892   

(2,596,770)  
11,115,502   
8,518,732    $

7,271    $
-    $

-    $
-    $
308,178    $
8,771    $
-    $

-    $
-    $

(171,076)
- 

(171,076)

3,888,000 
12,336,807 
250,000 
100,000 
(100,548)
171,375 

16,645,634 

10,444,554 
670,948 
11,115,502 

- 
- 

436,034 
721,154 
- 
- 
359,683 

250,788 
270,000 

$

$
$

$
$
$
$
$

$
$

 
 
 
 
 
 
 
 
 
   
 
 
 
 
   
 
 
 
 
    
 
  
 
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
See accompanying notes to consolidated financial statements.

F-6

 
Guardion Health Sciences, Inc.
Notes to Consolidated Financial Statements
Years Ended December 31, 2020 and 2019

1.

Business and Summary of Significant Accounting Policies

Business

Guardion Health Sciences, Inc. (the “Company”) is a specialty health sciences company (1) that has developed medical foods and medical devices in the
ocular health space and (2) that is developing nutraceuticals that the Company believes will provide supportive health benefits to consumers. The Company
has been primarily engaged in research and development, product commercialization and capital raising activities.

The Company was formed in December 2009 as a California limited liability company under the name P4L Health Sciences, LLC. On June 30, 2015, the
Company  converted  from  a  California  limited  liability  company  to  a  Delaware  corporation,  changing  its  name  from  Guardion  Health  Sciences,  LLC  to
Guardion Health Sciences, Inc.

Liquidity

The accompanying consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and the
settlement of liabilities and commitments in the normal course of business. For the year ended December 31, 2020, the Company incurred a net loss of
$8,571,657 and used cash in operating activities of $8,013,929. At December 31, 2020, the Company had cash on hand of $8,518,732 and working capital
of  $8,021,152.  Subsequent  to  December  31,  2020,  the  Company  sold  an  aggregate  of  7,566,734  shares  of  its  common  stock  for  net  proceeds  of
approximately $33,600,000 in two offerings, one completed in January 2021, and one completed in February 2021. In addition, in January and February
2021, the Company issued an aggregate of 1,647,691 shares of common stock upon the exercise of warrants and received cash proceeds of $3,608,509.
Notwithstanding the net loss for 2020, management believes that its current cash balance, plus net proceeds from issuance of common stock and exercise of
warrants in January and February 2021, is sufficient to fund operations for at least one year from the date the Company’s 2020 financial statements are
issued.

The Company expects to continue to incur net losses and negative operating cash flows in the near-term, and will continue to incur significant expenses for
development and commercialization of its medical foods and medical devices, and the successful development and commercialization of any new products
or product lines. The Company may also utilize cash to fund acquisitions.

The Company may seek to raise additional debt and/or equity capital to fund future operations, but there can be no assurances that the Company will be
able to secure such additional financing in the amounts necessary to fully fund its operating requirements on acceptable terms or at all. Over time, if the
Company is unable to access sufficient capital resources on a timely basis, the Company may be forced to reduce or discontinue its technology and product
development programs and curtail or cease operations.

COVID-19

The Company is subject to risks and uncertainties of the COVID-19 pandemic that could adversely impact our business, including the commercialization of
our medicines, our supply chain, our clinical trials, our liquidity and access to capital markets and our business development activities. The Company has
implemented additional health and safety precautions and protocols in response to the pandemic and government guidelines, including curtailing employee
travel and working from its executive offices, with many employees continuing their work remotely. During 2020, sales of certain products remained flat,
as many eye doctor offices were closed, or operating with limited capacity, due to COVID-19 related “shelter at home” orders. During 2020, we did not
experience a jeopardization of our supply chain due to the COVID-19 outbreak.

The extent of the impact of the COVID-19 pandemic has had and will continue to have on the Company’s business is highly uncertain and difficult to
predict and quantify. The full extent to which the COVID-19 pandemic will directly or indirectly impact the Company’s business, results of operations and
financial condition, will depend on future developments that are highly uncertain, including as a result of new information that may emerge concerning
COVID-19  and  the  actions  taken  to  contain  or  treat  it,  including  vaccination  efforts,  as  well  as  the  economic  impact  on  local,  regional,  national  and
international markets.

F-7

 
 
 
 
 
 
 
 
 
 
 
 
 
 
NASDAQ Notice and Compliance

On September 20, 2019, the Company received notice from the Listing Qualifications staff (the “Staff”) of The Nasdaq Stock Market LLC (“Nasdaq”)
indicating that, based upon the closing bid price of the Company’s common stock for the previous 30 consecutive business days, the Company no longer
satisfied the requirement to maintain a minimum bid price of $1.00 per share, as required by Nasdaq Listing Rule 5550(a)(2) (the “Bid Price Rule”). In
accordance with the Nasdaq Listing Rules, the Company was afforded 180 days, or until March 18, 2020, to regain compliance with the Bid Price Rule by
evidence of a closing bid price of at least $1.00 per share for a minimum of 10 consecutive business days. Thereafter, the Company had been afforded a
second 180-calendar day compliance period (which 180-day period was extended due to circumstances related to COVID-19), or until November 30, 2020,
to regain compliance with the Bid Price Rule.

The Company was unable to regain compliance with the Bid Price Rule by November 30, 2020. Accordingly, on December 1, 2020, the Company received
a  letter  from  the  Staff  notifying  it  that  its  Common  Stock  would  be  subject  to  delisting  from  Nasdaq  unless  the  Company  timely  appealed  Nasdaq’s
determination to a Nasdaq Listing Qualifications Panel (the “Panel”). The Company timely appealed Nasdaq’s determination to the Panel.

On January 26, 2021, the Company received written notification that the Panel granted the Company an extension for continued listing through March 15,
2021.

On March 1, 2021, the Company implemented the Reverse Stock Split (as defined below).

On March 15, 2021, the Company received a letter from the Staff notifying it that it had regained compliance with the Bid Price Rule. The letter stated the
staff  had  determined  that  for  the  prior  10  consecutive  business  days,  from  March  1,  2021  to  March  12,  2021,  the  closing  bid  price  of  the  Company’s
common stock had been at $1.00 per share or greater and that accordingly, the Company had regained compliance under the Bid Price Rule, and that the
matter was closed.

Reverse Stock Splits

On January 30, 2019, following stockholder and board approval, the Company effected a 1-for-2 reverse split of its outstanding shares of common stock,
without any change to its par value. The authorized number of shares of common stock were not affected by the reverse stock split. No fractional shares
were issued in connection with the reverse stock split, as all fractional shares were rounded up to the next whole share.

On March 1, 2021, following stockholder and board approval, the Company effectuated a 1-for-6 reverse split of its outstanding shares of common stock,
without any change to its par value.  The authorized number of shares of common stock were not affected by the reverse stock split. No fractional shares
were issued in connection with the reverse stock split, as all fractional shares were rounded up to the next whole share.

Accordingly, all share and per share amounts presented herein with respect to common stock have been retroactively adjusted to reflect the above described
reverse stock splits for all periods presented.

Basis of presentation

The Company has prepared its consolidated financial statements in accordance with accounting practices generally accepted in the United States (“U.S.
GAAP”) and has adopted accounting policies and practices which are generally accepted in the industry in which it operates. The Company’s significant
accounting policies are summarized below.

Principles of consolidation

The  consolidated  financial  statements  include  the  accounts  of  the  Company  and  its  wholly  owned  subsidiaries,  VectorVision  Ocular  Health,  Inc.,
NutriGuard Formulations, Inc., and Transcranial Doppler Solutions, Inc. All intercompany balances and transactions have been eliminated in consolidation.

Use of Estimates

The preparation of our financial statements in conformity with accounting principles generally accepted in the United States of America (“GAAP”) requires
management to make certain estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses, and the disclosure of
contingent assets and liabilities. Actual results could differ from those estimates. On an ongoing basis, management reviews its estimates and if deemed
appropriate,  those  estimates  are  adjusted.  Significant  estimates  include  those  related  to  assumptions  used  in  valuing  inventories  at  net  realizable  value,
assumptions  used  in  valuing  assets  acquired  in  business  acquisitions,  impairment  testing  of  goodwill  and  other  long-term  assets,  assumptions  used  in
valuing  stock-based  compensation,  the  valuation  allowance  for  deferred  tax  assets,  accruals  for  potential  liabilities,  and  assumptions  used  in  the
determination of the Company’s liquidity. Actual results could differ from those estimates.

Revenue Recognition

The Company generates its revenue from two business segments:

● Medical Foods and Nutraceuticals Segment
● Medical Devices Segment

The Company recognizes revenue in accordance with Accounting Standards Codification (“ASC”) 606, Revenue from Contracts with Customers. Revenue
is recognized when control of promised goods or services is transferred to the customer in an amount that reflects the consideration to which the Company
expects to be entitled in exchange for those products or services. The Company reviews its sales transactions to identify contractual rights, performance
obligations, and transaction prices, including the allocation of prices to separate performance obligations, if applicable.

All products sold by the Company are distinct individual products and are offered for sale as finished goods only, and there are no performance obligations
required post-shipment for customers to derive the expected value from them. Contracts with customers contain no incentives or discounts that could cause
revenue to be allocated or adjusted over time.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Shipping and handling activities are performed before the customer obtains control of the goods and therefore represent a fulfillment activity rather than a
promised service to the customer. Payments for sales of medical foods and dietary supplements are generally made by approved credit cards. Payments for
medical  device  sales  are  generally  made  by  check,  credit  card,  or  wire  transfer.  Historically  the  Company  has  not  experienced  any  significant  payment
delays from customers.

F-8

 
The Company provides a 30-day right of return to its retail customers. A right of return does not represent a separate performance obligation, but because
customers are allowed to return products, the consideration to which the Company expects to be entitled is variable. Upon evaluation of historical product
returns, the Company determined that less than one percent of products is returned, and therefore believes it is probable that such returns will not cause a
significant  reversal  of  revenue  in  the  future.  Due  to  the  insignificant  amount  of  historical  returns  as  well  as  the  standalone  nature  of  the  Company’s
products and assessment of performance obligations and transaction pricing for the Company’s sales contracts, the Company does not currently maintain a
contract asset or liability balance at this time. The Company assesses its contracts and the reasonableness of its conclusions on a quarterly basis.

Revenues by segment:

Medical Foods and Nutraceuticals
Medical Devices
Other

Years Ended December 31,
2019
2020

  $

  $

1,609,482    $
275,862   
4,500   
1,889,844    $

444,657 
434,010 
24,270 
902,937 

During  the  year  ended  December  31,  2020,  the  Company  recorded  a  sale  to  the  Malaysian  company  of  approximately  $890,000.  The  remainder  of  the
Company’s Medical Foods and Nutraceuticals revenues earned during the year ended December 31, 2020 are derived from individual retail customers in
North  America.  During  the  year  ended  December  31,  2019,  all  the  Company’s  Medical  Foods  and  Nutraceuticals  revenues  are  derived  from  individual
retail  customers  in  North  America.  Medical  Devices  revenues  are  derived  from  a  worldwide  customer  base  consisting  of  both  retail  customers  and
distributors. Sales to distributors were approximately 51% and 62% of total revenues for the years ended December 31, 2020 and 2019, respectively.

Revenues by geographical area:

North America
Malaysia
Other Asia
Europe and Other

Years Ended December 31,
2019
2020

  $

  $

891,768    $
889,508   
58,688   
49,880   
1,889,844    $

725,520 

129,453 
47,964 
902,937 

Medical  Devices  revenues  are  derived  from  a  worldwide  customer  base  consisting  of  both  retail  customers  and  distributors.  Sales  to  distributors  were
approximately 51% and 62% of total revenues for the years ended December 31, 2020 and 2019, respectively.

Cash

Cash consists of cash and demand deposits with banks. The Company holds no cash equivalents as of December 31, 2020 and 2019, respectively.

F-9

 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
Accounts Receivable

Accounts  receivable  are  recorded  at  the  invoiced  amounts.  Management  evaluates  the  collectability  of  its  trade  accounts  receivable  and  determines  an
allowance for doubtful accounts based on historical write-offs, known or expected trends, and the identification of specific balances deemed uncollectible
based on a customer’s financial condition, credit history and the current economic conditions.

At December 31, 2020 and 2019, based on management’s assessment, no allowance for doubtful accounts was considered necessary.

Inventories

Inventories  are  stated  at  the  lower  of  cost  or  net  realizable  value,  with  cost  determined  on  a  first-in,  first-out  (“FIFO”)  basis.  The  Company  records
adjustments to its inventory for estimated obsolescence or diminution in net realizable value equal to the difference between the cost of the inventory and
the estimated net realizable value. When evidence exists that the net realizable value of inventory is lower than its cost, the difference is recognized as a
loss in the period in which it occurs. Once inventory has been written down, it creates a new cost basis for inventory that may not subsequently written up.
For the year ended December 31, 2020, the Company wrote-down inventory of $971,719, which was recorded in cost of sales (see Note 3). For the year
ended December 31, 2019, there were no write-downs of inventory.

Property and Equipment

Property  and  equipment  are  recorded  at  cost  less  accumulated  depreciation.  Additions,  improvements,  and  major  renewals  or  replacements  that
substantially extend the useful life of an asset are capitalized. Repairs and maintenance expenditures are expensed as incurred. Depreciation is computed
using the straight-line method over the estimated useful lives of the related assets, which range from three to seven years. Leasehold improvements are
amortized on a straight-line basis over the shorter of their estimated useful lives or the remaining lease term.

Management assesses the carrying value of property and equipment whenever events or changes in circumstances indicate that the carrying value may not
be recoverable. If there is indication of impairment, management prepares an estimate of future cash flows expected to result from the use of the asset and
its eventual disposition. If these cash flows are less than the carrying amount of the asset, an impairment loss is recognized to write down the asset to its
estimated fair value at that time. At December 31, 2020 and 2019, management determined there were no impairments of the Company’s property and
equipment.

Leases

The Company determines whether a contract is, or contains, a lease at inception. Right-of-use assets represent the Company’s right to use an underlying
asset during the lease term, and lease liabilities represent the Company’s obligation to make lease payments arising from the lease. Right-of-use assets and
lease liabilities are recognized at lease commencement based upon the estimated present value of unpaid lease payments over the lease term. The Company
uses its incremental borrowing rate based on the information available at lease commencement in determining the present value of unpaid lease payments.

Intangible Assets

Finite-lived intangible assets

Amortizable identifiable intangible assets are stated at cost less accumulated amortization, and represent customer relationships, technology, trade names,
and  noncompetition  agreements  acquired  in  business  combinations.  The  Company  follows  ASC  360  in  accounting  for  intangible  assets,  which  requires
impairment losses to be recorded when indicators of impairment are present and the undiscounted cash flows estimated to be generated by the assets are
less  than  the  assets’  carrying  amounts.  As  of  December  31,  2019,  the  recorded  value  of  the  Company’s  finite-lived  intangible  assets  had  been  fully
amortized.

F-10

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Indefinite-lived intangible assets

Intangible  assets  are  comprised  of  an  indefinite-lived  trademark  acquired,  so  classified  because  the  Company  can  renew  the  underlying  rights  to  the
trademark indefinitely at nominal cost. Indefinite-lived intangible assets are not amortized but are assessed for impairment annually and evaluated annually
to determine whether the indefinite useful life is appropriate. As part of our impairment test, we first assess qualitative factors to determine whether it is
more  likely  than  not  the  asset  is  impaired.  If  further  testing  is  necessary,  we  compare  the  estimated  fair  value  of  our  asset  with  its  book  value.  If  the
carrying amount of the asset exceeds its fair value, as determined by its discounted cash flows, an impairment loss is recognized in an amount equal to that
excess. For the years ended December 31, 2020 and 2019, the Company determined there were no impairments of its indefinite-lived brand names (see
Note 5).

Goodwill

Goodwill  is  the  excess  of  cost  of  an  acquired  entity  over  the  fair  value  of  amounts  assigned  to  assets  acquired  and  liabilities  assumed  in  a  business
combination.  Under  the  guidance  of  ASC  350,  goodwill  is  not  amortized,  rather  it  is  tested  for  impairment  annually,  and  will  be  tested  for  impairment
between annual tests if an event occurs or circumstances change that would indicate the carrying amount may be impaired. An impairment loss generally
would  be  recognized  when  the  carrying  amount  of  the  reporting  unit’s  net  assets  exceeds  the  estimated  fair  value  of  the  reporting  unit  and  would  be
measured  as  the  excess  carrying  value  of  goodwill  over  the  derived  fair  value  of  goodwill.  The  Company’s  policy  is  to  perform  an  annual  impairment
testing for its reporting units on December 31 of each fiscal year. During the year ended December 31, 2019, the Company recorded an impairment of its
remaining goodwill of $1,563,520 (see Note 5). Accordingly, at December 31, 2020, the Company did not have any goodwill.

Stock-Based Compensation

The Company periodically issues stock-based compensation to officers, directors, contractors and consultants for services rendered. Such issuances vest
and expire according to terms established at the issuance date.

Stock-based payments to employees, directors, and for acquiring goods and services from nonemployees, which include grants of employee stock options,
are recognized in the financial statements based on their grant date fair values in accordance with ASC 718, Compensation-Stock Compensation.  Stock
option grants, which are generally time or performance vested, are measured at the grant date fair value and depending on the conditions associated with
the vesting of the award, compensation cost is recognized on a straight-line or graded basis over the vesting period. The fair value of stock options granted
is estimated using the Black-Scholes option-pricing model, which uses certain assumptions related to risk-free interest rates, expected volatility, expected
life,  and  future  dividends.  The  assumptions  used  in  the  Black-Scholes  option  pricing  model  could  materially  affect  compensation  expense  recorded  in
future periods.

Income Taxes

The Company uses an asset and liability approach for accounting and reporting for income taxes that allows recognition and measurement of deferred tax
assets based upon the likelihood of realization of tax benefits in future years. Under the asset and liability approach, deferred taxes are provided for the net
tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income
tax purposes. A valuation allowance is provided for deferred tax assets if it is more likely than not these items will either expire before the Company is able
to  realize  their  benefits,  or  that  future  deductibility  is  uncertain.  The  Company’s  policy  is  to  recognize  interest  and/or  penalties  related  to  income  tax
matters in income tax expense.

Research and Development Costs

Research and development costs are expensed as incurred and consist primarily of fees paid to consultants and outside service providers, patent fees and
costs, and other expenses relating to the acquisition, design, development and testing of the Company’s products. Research and development expenditures,
which include stock compensation expense, totaled $160,978 and $194,311 for the years ended December 31, 2020 and 2019, respectively.

F-11

 
 
 
 
 
 
 
 
 
 
 
 
 
Patent Costs

The Company is the owner of three issued domestic patents, three pending domestic patent applications, one issued foreign patent in Europe, one issued
foreign patent in Hong Kong, and three foreign patent applications in Canada, Europe and Hong Kong. Due to the significant uncertainty associated with
the  successful  development  of  one  or  more  commercially  viable  products  based  on  the  Company’s  research  efforts  and  any  related  patent  applications,
patent costs, including patent-related legal fees, filing fees and internally generated costs, are expensed as incurred. During the years ended December 31,
2020 and 2019, patent costs were $124,806 and $137,183, respectively, and are included in general and administrative costs in the statements of operations.

Advertising Costs

Advertising costs are expensed as incurred and are included in sales and marketing expense. Advertising costs aggregated $44,429 and $19,645 for the
years ended December 31, 2020 and 2019, respectively.

Loss per Common Share

Basic loss per share is computed by dividing net loss by the weighted-average common shares outstanding during a period. Diluted earnings per share is
computed based on the weighted-average common shares outstanding plus the effect of dilutive potential common shares outstanding during the period
calculated using the treasury stock method. Dilutive potential common shares include shares from unexercised warrants and options. Potential common
share equivalents have been excluded where their inclusion would be anti-dilutive. The Company’s basic and diluted net loss per share is the same for all
periods presented because all shares issuable upon exercise of warrants and options are anti-dilutive.

The following potentially dilutive shares were excluded from the shares used to calculate diluted earnings per share:

Warrants
Options

Fair Value of Financial Instruments

December 31,

2020

2019

2,132,758   
778,195   
2,910,953   

4,800,456 
493,750 
5,294,206 

Accounting standards require certain assets and liabilities be reported at fair value in the financial statements and provide a framework for establishing that
fair value. Fair value is defined as the price that would be received upon sale of an asset or paid to transfer a liability in an orderly transaction between
market participants at the measurement date. When determining fair value, the Company considers the principal or most advantageous market in which it
transacts, and considers assumptions that market participants would use when pricing the asset or liability. The framework for determining fair value is
based on a hierarchy that prioritizes the inputs and valuation techniques used to measure fair value:

Level 1 - Quoted prices in active markets for an identical asset or liability that the Company has the ability to access as of the measurement date.

Level 2 - Inputs, other than quoted prices included within Level 1, which are directly observable for the asset or liability or indirectly observable through
corroboration with observable market data.

Level 3 - Unobservable  inputs  in  which  there  is  little  or  no  market  data  for  the  asset  or  liability  which  requires  the  reporting  entity  to  develop  its  own
assumptions.

The Company determines the level in the fair value hierarchy within which each fair value measurement falls in its entirety, based on the lowest level input
that is significant to the fair value measurement in its entirety. In determining the appropriate levels, the Company performs an analysis of the assets and
liabilities at each reporting period end.

The  Company  believes  the  carrying  amount  of  its  financial  instruments  (consisting  of  cash,  accounts  receivable,  and  accounts  payable  and  accrued
liabilities) approximates fair value due to the short-term nature of such instruments.

As of December 31, 2020, and 2019, the Company’s balance sheet included Level 2 liabilities comprised of the fair value of warrant liabilities aggregating
$25,978 and $13,323, respectively (see Note 9).

F-12

 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Derivative Financial Instruments

The Company evaluates its financial instruments to determine if such instruments are derivatives or contain features that qualify as embedded derivatives.
For derivative financial instruments that are accounted for as liabilities, the derivative instrument is initially recorded at its fair value and is then re-valued
at each reporting date, with changes in the fair value reported in the consolidated statements of operations. The classification of derivative instruments,
including whether such instruments should be recorded as liabilities or as equity, is evaluated at the end of each reporting period. Derivative instrument
liabilities are classified in the balance sheet as current or non-current based on whether or not net-cash settlement of the derivative instrument could be
required within 12 months of the balance sheet date.

Concentrations

Cash  balances  are  maintained  at  large,  well-established  financial  institutions.  At  times,  cash  balances  may  exceed  federally  insured  limits.  Insurance
coverage limits are $250,000 per depositor at each financial institution. The Company believes that no significant concentration of credit risk exists with
respect to its cash balances because of its assessment of the creditworthiness and financial viability of the financial institutions.

During the year ended December 31, 2020, one customer accounted for approximately 47% of the Company’s sales. During the year ended December 31,
2019, one customer who accounted for approximately 22% of the Company’s sales. No other customer accounted for more than 10% of sales in either year.

Recent Accounting Pronouncements

In  August  2020,  the  FASB  issued  ASU  No.  2020-06  (“ASU  2020-06”)  “Debt—Debt  with  Conversion  and  Other  Options  (Subtopic  470-20)  and
Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity’s Own
Equity.”  ASU  2020-06  will  simplify  the  accounting  for  convertible  instruments  by  reducing  the  number  of  accounting  models  for  convertible  debt
instruments and convertible preferred stock. Limiting the accounting models will result in fewer embedded conversion features being separately recognized
from  the  host  contract  as  compared  with  current  GAAP.  Convertible  instruments  that  continue  to  be  subject  to  separation  models  are  (1)  those  with
embedded conversion features that are not clearly and closely related to the host contract, that meet the definition of a derivative, and that do not qualify for
a scope exception from derivative accounting and (2) convertible debt instruments issued with substantial premiums for which the premiums are recorded
as paid-in capital. ASU 2020-06 also amends the guidance for the derivatives scope exception for contracts in an entity’s own equity to reduce form-over-
substance-based accounting conclusions. ASU 2020-06 will be effective January 1, 2024, for the Company. Early adoption is permitted, but no earlier than
January  1,  2021,  including  interim  periods  within  that  year.  Management  is  currently  evaluating  the  effect  of  the  adoption  of  ASU  2020-06  on  the
consolidated financial statements, but currently does not believe ASU 2020-06 will have a significant impact on the Company’s financial statements. The
effect will largely depend on the composition and terms of the outstanding financial instruments at the time of adoption.

In  December  2019,  the  FASB  issued  ASU  2019-12,  Income  Taxes  (topic  740):  Simplifying  the  Accounting  for  Income  Taxes  (“ASU  2019-12”). ASU
2019-12  simplifies  the  accounting  for  income  taxes  by  removing  certain  exceptions  and  enhances  and  simplifies  various  aspects  of  the  income  tax
accounting guidance in ASC 740. ASU 2019-12 is not expected to have any impact on the Company’s consolidated financial statement presentation or
disclosures subsequent to its adoption.

In June 2016, the FASB issued ASU No. 2016-13, Credit Losses - Measurement of Credit Losses on Financial Instruments (“ASC 326”). The standard
significantly changes how entities will measure credit losses for most financial assets, including accounts and notes receivables. The standard will replace
today’s “incurred loss” approach with an “expected loss” model, under which companies will recognize allowances based on expected rather than incurred
losses. Entities will apply the standard’s provisions as a cumulative-effect adjustment to retained earnings as of the beginning of the first reporting period in
which the guidance is effective. As a smaller reporting company, ASU 2016-13 will be effective for us beginning January 1, 2023, with early adoption
permitted. The Company is currently assessing the impact of adopting this standard on the Company’s financial statements and related disclosures.

The Company’s management does not believe that any other recently issued, but not yet effective, authoritative guidance, if currently adopted, would have
a material impact on the Company’s financial statement presentation or disclosures.

F-13

 
 
 
 
 
 
 
 
 
 
 
 
2.

Acquisition of NutriGuard

Effective  September  20,  2019  (the  “Effective  Date”),  the  Company’s  wholly-owned  subsidiary,  NutriGuard  Formulations,  Inc.,  a  Delaware  corporation,
completed an asset purchase agreement (the “Asset Purchase Agreement”) with NutriGuard Research, Inc., a California corporation (“NutriGuard”), and
NutriGuard’s sole shareholder, Mark McCarty.

Pursuant  to  the  Asset  Purchase  Agreement,  the  Company  purchased  specified  assets  of  the  NutriGuard  brand  and  business,  consisting  primarily  of
inventory, trademarks, copyrights and other intellectual property. In exchange, the Company agreed to pay a 3% royalty, payable quarterly, to NutriGuard
based on the operating results of the NutriGuard branded products in future periods, after $500,000 in gross revenues have been achieved by the Company.
The Company was unable to reasonably estimate the timing or amount of future revenue streams that would generate royalty payments, as the Company
will need to develop new product formulations and implement a marketing and distribution infrastructure, which will require the investment of a significant
amount of capital over an extended period of time. Accordingly, any royalty payments in the future will be charged directly to operations when incurred.

As the Company did not pay any cash or non-cash consideration, nor did it assume any liabilities, in conjunction with this acquisition, the Company did not
recognize any tangible or intangible assets at closing. All costs related to this transaction, consisting primarily of legal fees, were charged to operations as
incurred.  Although  NutriGuard  conducted  limited  operations  with  nominal  revenues  prior  to  its  acquisition,  the  Company  has  determined  that  the
NutriGuard acquisition qualified as the acquisition of a business under Accounting Standards Codification (“ASC”) 805: Business Combinations (“ASC
805”). However, the recent historical operations of NutriGuard did not meet any of the three-element significance level tests (investment, assets and pre-tax
income) with regard to the accounting standards requiring acquisition company financial statements and related pro forma financial information, and the
Company  has  therefore  concluded  that  the  acquisition  of  NutriGuard  was  not  significant.  The  value  of  the  NutriGuard  business  consists  primarily  of
intangible  assets  for  which  no  accounting  value  was  attributed  in  the  Company’s  financial  statements.  The  Company  intends  to  utilize  these  intangible
assets to build a nutraceutical brand and product portfolio based on updated and reformulated compounds, which will require the investment of a significant
amount of capital over an extended period of time.

The operations of Nutriguard have been included in the Company’s consolidated results of operations starting September 20, 2019.

The following unaudited pro forma financial information gives effect to the Company’s acquisition of NutriGuard as if the acquisition had occurred on
January 1, 2019:

Pro forma net revenues
Pro forma net loss attributable to common shareholders
Pro forma net loss per share

Year Ended
December 31,
2019

  $
  $
  $

963,167 
(10,913,833)
(1.80)

On the Effective Date, Mr. McCarty entered into a consulting agreement with the Company and provides that Mr. McCarty will serve as the Director of
Research  of  the  Company  for  a  period  of  3  years  at  a  rate  of  $7,500  per  month  for  12  months  and  $5,000  per  month  thereafter.  It  is  intended  that  Mr.
McCarty will assist the Company, among other tasks, in developing new formulations for distribution under the NutriGuard brand, as well as identifying
production sources for such compounds and developing distribution networks for such products.

Pursuant to the consulting agreement, the Company granted Mr. McCarty stock options to purchase 16,667 shares of the Company’s common stock with a
grant  date  fair  value  of  $54,004  and  an  exercise  price  of  $3.24  per  share,  which  was  the  closing  market  price  of  the  Company’s  common  stock  on  the
Effective Date. The stock options were granted under the terms of the Company’s 2018 Equity Incentive Plan, and the options vest as follows: 25% on the
Effective Date, 25% on the first anniversary following the Effective Date, 25% on the second anniversary following the Effective Date, and 25% on the
third anniversary following the Effective Date.

F-14

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
3.

Inventories

Inventories consisted of the following:

Raw materials
Finished goods
Inventory

December 31,

2020

2019

  $

  $

218,307    $
166,665   
384,972    $

246,875 
64,066 
310,941 

The Company’s inventories are stated at the lower of cost or net realizable value on a FIFO basis. At December 31, 2020, as a result of the deterioration of
the  forecasted  marketability  of  certain  of  the  Company’s  inventory,  management  determined  that  the  inventory’s  revenue-generating  ability  was
diminished, and the net realizable value of this inventory had fallen below its historical carrying cost. Accordingly, for the year ended December 31, 2020,
the Company recorded a write down of inventory of $971,719, which is included in cost of goods sold. At December 31, 2020, the balance of inventory
reflects its new cost basis after the write down. For the year ended December 31, 2019, there were no write-downs of inventory. At December 31, 2020 and
2019, inventory has been reduced by cumulative write-downs totaling $1,028,324 and $56,605, respectively.

4.

Property and Equipment, net

Property and equipment consisted of the following:

Leasehold improvements
Testing equipment
Furniture and fixtures
Computer equipment
Office equipment

Less accumulated depreciation and amortization

December 31,

2020

2019

103,255    $
348,124   
197,349   
68,460   
9,835   
727,023   
(441,347)  
285,676    $

98,357 
394,427 
185,799 
68,460 
8,193 
755,236 
(380,598)
374,638 

  $

  $

For the years ended December 31, 2020 and 2019, depreciation and amortization expense was $65,476 and $71,242, respectively, of which $35,846 and
$33,004 was included in research and development expense, $13,252 and $15,641 was included in sales and marketing expense, and $16,378 and $22,597
was included in general and administrative expense, respectively. The following table shows where depreciation expense was recorded for the years ended
December 31, 2019 and 2020:

Research and development expense
Sales and marketing expense
General and administrative expense

5.

Intangible Assets

The Company’s intangible assets consisted of the following:

Trademark

Indefinite-lived intangible trademark asset

Years Ended December 31,
2019
2020

  $

  $

35,846    $
13,252   
16,378   
65,476    $

33,004 
15,641 
22,597 
71,242 

December 31,

2020

2019

  $

50,000    $

50,000 

In  January  2018,  the  Company  acquired  the  rights  to  the  trademark  GLAUCO-HEALTH  as  well  as  the  name  “International  Eye  Wellness  Institute”
(together, the “IP Assets”) from an unrelated third party. The purchase included all rights, title, and interest in and to the IP Assets, including (a) the right to
register and use the IP Assets; (b) all goodwill associated with the IP Assets; (c) all income, royalties, and damages hereafter due or payable with respect to
the IP Assets; (d) all rights to sue for past, present, and future infringements or misappropriations of the IP Assets; and all other intellectual property rights
owned or claimed by the seller or embodied in the IP Assets. In exchange for these rights, the Company paid the seller $50,000 in cash.

F-15

 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
The Company determined that the acquired intangible asset met the definition of a defensive intangible asset under ASC 350, and the Company accounted
for the $50,000 payment as an acquired intangible asset. As the Company can renew the underlying rights to the IP Assets indefinitely at nominal cost, the
assets  have  been  classified  as  a  non-amortizable  intangible  asset  on  the  Company’s  balance  sheet.  The  Company  evaluates  the  status  of  the  assets  for
impairment annually or more frequently if warranted. Based on management’s assessment, there were no indications of impairment at December 31, 2020
or 2019 for the IP Assets.

Identifiable finite-lived intangible assets and goodwill related to VectorVision

In September 2017, the Company acquired VectorVision, Inc. (“VectorVision”) in exchange for 508,334 shares of the Company’s common stock, valued at
$2,300,000 million. In accordance with ASC 805, the purchase consideration was allocated to tangible and intangible assets at their estimated fair values on
the date of acquisition. The intangible assets included $674,400 of finite-lived intangible assets including customer relationships, technology, trade names,
and noncompetition, and $1,563,520 of goodwill. At December 31, 2018, the net book value of the finite-lived intangible assets was $406,104, and the net
book  value  of  the  goodwill  was  $1,563,520.  During  the  fourth  quarter  of  2019,  the  Company  conducted  its  annual  impairment  analysis,  considering
multiple qualitative observations and indicators, including our customer relationships, the regulatory environment as it impacts medical devices, market
penetration expectations and barriers, and our anticipated competitive environment.

Although management believes in the future growth and success of the VectorVision business, development of the CSV-2000 took longer than expected
due to software engineering and other factors. Although we believe we will enjoy a significant market share over time, there is subjectivity of predicting the
amount and timing of that value. Recent changes in the regulatory environment may cost us more than anticipated to begin marketing the new device in
Europe.

Accordingly,  management  concluded  that  as  of  December  31,  2019,  the  fair  value  of  the  goodwill  and  finite-lived  intangible  assets  associated  with  the
VectorVision  acquisition  were  less  than  their  respective  carrying  amounts.  For  the  year  ended  December  31,  2019,  the  Company  recorded  a  goodwill
impairment charge of $1,563,520, and an additional charge of $406,104 to fully amortize the balance of the finite-lived intangible assets recorded in the
VectorVision acquisition.

6.

Operating Leases

The Company leases certain office and warehouse spaces under operating leases. In October 2012, the Company entered into a lease agreement for 9,605
square feet of office and warehouse space commencing March 1, 2013. The lease (“Lease 1”) was renewed for an additional five years in 2018 through
July  2023.  In  connection  with  the  VectorVision  acquisition  (see  Note  5),  the  Company  assumed  a  lease  agreement  (“Lease  2”)  for  5,000  square  feet  of
office and warehouse space which commenced October 1, 2017 through February 2023.

In  accounting  for  the  leases,  the  Company  adopted  ASC  842  Leases  on  January  1,  2019,  which  requires  a  lessee  to  record  a  right-of-use  asset  and  a
corresponding lease liability at the inception of the lease initially measured at the present value of the lease payments. The Company classified the leases as
operating  leases  and  at  January  1,  2019,  determined  that  the  present  value  of  Lease  1  payments  was  $639,520  and  that  the  present  value  of  Lease  2
payments  was  $81,634,  or  an  aggregate  of  $721,154,  using  a  discount  rate  of  3.9%.  In  accordance  with  ASC  842,  the  right-of-use  assets  are  being
amortized over the life of the underlying leases. During the year ended December 31, 2020, the Company reflected amortization of right-of-use asset of
$154,124. At December 31, 2020, accumulated amortization of the right-of-use assets was $302,564, resulting in a net asset balance of $418,590.

F-16

 
 
 
 
 
 
 
 
 
 
During  the  year  ended  December  31,  2020,  the  Company  made  combined  payments  on  both  leases  of  $151,767  towards  the  lease  liabilities.  As  of
December 31, 2020, the lease liability for Lease 1 was $388,001, and the lease liability for Lease 2 was $46,746, or an aggregate of $434,747. ASC 842
requires recognition in the statement of operations of a single lease cost, calculated so that the cost of the lease is allocated over the lease term, generally on
a straight-line basis. Combined rent expense for both leases for the years ended December 31, 2020 and 2019 was $174,323 and $174,323, respectively.

Maturities of the Company’s lease liabilities are as follows:

Year ending

2021
2022
2023
Total lease payments
Less: Imputed interest/present value discount
Present value of lease liabilities
Less Current portion

7.

Settlement with Former Officer

Operating Leases

$

$

176,934 
182,249 
98,417 
457,600 
(22,852)
434,748 
(162,845)
271,903 

Effective June 15, 2020, Michael Favish resigned as Chief Executive Officer and as an employee of the Company and resigned from the Company’s Board
of Directors. Terms of the settlement agreement between the parties included the continuation of his previous salary of $325,000 during the twelve months
subsequent to his resignation. The $325,000 of aggregate settlement payments was recorded in costs related to resignation of former officer expense in the
accompanying  consolidated  statements  of  operations  for  the  year  ended  December  31,  2020.  As  of  December  31,  2020,  $148,958  of  the  amount  due
remains accrued on our consolidated balance sheet and is payable through June 2021. In addition, 138,889 options previously granted to the former officer
were forfeited (see Note 10).

8.

Notes Payable

Promissory Note

On March 12, 2019, the Company issued a promissory note with principal in the amount of $100,000, simple interest of 10% annually, and with a maturity
date of June 10, 2019. On April 11, 2019, the Company repaid the promissory note for a total of $100,548 including accrued interest.

Convertible Notes

In March 2019, the Company issued two convertible notes with aggregate principal in the amount of $250,000, simple interest of 5% annually, and with
maturity dates of September 30, 2019. The convertible notes (principal and accrued interest) were mandatorily convertible upon the consummation of the
Company’s IPO. In April 2019, upon the consummation of the IPO, the convertible notes and accrued interest with an aggregate balance of $250,788 were
mandatorily converted into 18,173 shares of common stock based on a conversion price of $13.80 per share in April 2019. Upon conversion a valuation
discount of $250,000 was recognized as interest expense.

Concurrent with the issuance of the notes, the Company issued warrants to the note holders equal to the number of shares of common stock that the holders
receive in connection with the converted notes. The per share exercise price of the warrants was set at 125% of the conversion price of the notes, defined in
the note agreements, as the lower of (a) 75% of the price per share of common stock of the IPO or (b) $13.80. The Company issued 18,173 warrants based
upon the completion of the IPO in April 2019.

Due to the variable terms of both the exercise price and the number of warrants to be issued, the warrants were accounted for as a derivative liability upon
issuance (see Note 9). The aggregate fair value of the warrant derivative liability was determined to be $436,034 based on a probability effected Black-
Scholes option pricing model with a stock price of $24.00, volatility of 138%, and risk-free rates ranging from 2.34% - 2.39%. The Company recognized a
debt discount of $250,000 equal to the face amount of the convertible notes and recorded a financing cost of $186,034 equal to the difference between the
fair value of the warrants and the debt discount. (see Note 9)

F-17

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
9.

Derivative Warrant Liability

Derivative for warrants issued to underwriter

On April 9, 2019, the Company issued 10,417 warrants with an exercise price of $30.00 per share to the underwriter in connection with the Company’s
IPO. The Company accounted for these warrants as a derivative liability in the financial statements at June 30, 2019 because they were associated with the
IPO, a registered offering, and the settlement provisions contained language that the shares underlying the warrants are required to be registered. The fair
value of the warrants is remeasured at each reporting period, and the change in the fair value is recognized in earnings in the accompanying statements of
operations. The fair value of the warrants at the date of issuance was determined to be $229,921 and was recorded as a finance cost. During the year ended
December 31, 2019, a decrease in the fair value of the derivative warrant liability of $216,598 was recorded, and at December 31, 2019, the fair value of
the derivative warrant liability was $13,323. During the year ended December 31, 2020, an increase in the fair value of the derivative warrant liability of
$12,655 was recorded, and at December 31, 2020, the fair value of the derivative warrant liability was $25,978.

Derivative for warrants issued with convertible notes in 2019 and reclassified to equity in 2019

In March 2019, the Company issued warrants to two convertible note holders pursuant to the anticipated completion of the Company’s IPO (the IPO was
completed on April 9, 2019). Due to the variable terms of both the exercise price and the number of warrants to be issued, the warrants were accounted for
as derivative liabilities at the issuance date. The Company estimated that the issuance of 18,173 warrants with an exercise price of $17.28 per share would
correspond to the number of shares of common stock that the holders would receive in connection with the completion of the IPO. The fair value of the
warrants  at  date  of  issuance  was  determined  to  be  $436,034,  of  which  $250,000  was  recorded  as  a  valuation  discount  and  $186,034  was  recorded  as  a
finance  cost.  Upon  completion  of  the  IPO,  the  exercise  price  and  the  number  of  warrants  were  fixed,  and  the  warrants  are  no  longer  accounted  for  as
liabilities. The fair value of the warrants at the completion of the IPO was determined to be $359,683, and such amount was reclassified to equity. This
resulted in the Company recognizing a decrease in derivative warrant liability of $76,351 during the year ended December 31, 2019.

The fair value of the warrant liability was determined at the following issuance and reporting dates using the Black-Scholes option pricing model and the
following assumptions:

Stock price
Risk free interest rate
Expected volatility
Expected life in years
Expected dividend yield
Number of warrants
Fair value of derivative warrant liability

Convertible
Notes issued
March 2019

Underwriter
warrants issued
April 2019

Warrant
Liability
December 31,
2019

Warrant
Liability
December 31,
2020

  $

  $

  $
24.00 
2.34 – 2.39%   
138%   
5.00 

0%   

18,173 
436,034 

  $

F-18

22.08 

  $
2.29%   
137%   
5.00 

0%   

10,417 
229,921 

  $

1.32 
1.62%   
145%   
4.3 

0%   

10,417 
13,323 

2.49 
0.17%
148%
3.8 

0%

10,417 
25,978 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
   
   
   
 
 
 
 
   
   
   
   
 
10.

Stockholders’ Equity

Common Stock

Sales of common stock

On April 9, 2019, the Company closed its initial public offering (the “IPO”) and issued 208,334 shares of its common stock at a public offering price of
$24.00 per share for total gross proceeds of $5.0 million pursuant to an underwriting agreement by and between the Company, WallachBeth Capital, LLC,
and WestPark Capital, Inc., acting as the representatives. On April 9, 2019, the Company issued 10,417 warrants with an exercise price of $30.00 per share
to the underwriters and affiliates in connection with the IPO. The Company accounted for these warrants as a derivative liability (see Note 9) upon issuance
because  they  were  associated  with  a  registered  offering,  and  the  settlement  provisions  contained  language  that  the  shares  underlying  the  warrants  are
required to be registered. Net proceeds to the Company were $3,888,000 after deducting underwriting discounts, commissions, and other offering expenses.

On August 15, 2019, the Company closed a second public offering consisting of (i) 2,000,000 shares of common stock, par value $0.001 per share, of the
Company, (ii) pre-funded warrants exercisable for 166,667 shares of common stock, and (iii) warrants to purchase up to an aggregate of 2,166,667 shares
of common stock pursuant to an underwriting agreement by and between the Company, Maxim Group LLC, and WallachBeth Capital LLC, acting as the
representatives.  On  August  16,  2019,  the  Company  sold  an  additional  325,000  warrants  upon  exercise  of  the  underwriters’  over-allotment  option.  The
public offering price was $2.64 per share of common stock, $2.58 per pre-funded warrant and $0.06 per accompanying warrant. On August 15, 2019, the
Company  issued  173,334  warrants  with  an  exercise  price  of  3.00  per  share  to  the  underwriters  in  connection  with  the  offering.  Net  proceeds  to  the
Company were $4,944,340 after deducting underwriting discounts, commissions, and other offering expenses.

On October 30, 2019, the Company completed an underwritten public offering of 3,800,000 shares of its common stock plus 283,334 pre-funded warrants
to  purchase  common  stock  in  lieu  thereof  and  Series  B  warrants  to  purchase  up  to  4,083,334  shares  of  the  Company’s  common  stock.  Each  share  of
common stock (or pre-funded warrant) was sold together with one Series B warrant to purchase one share of common stock at a combined price to the
public of $2.05 per share and Series B warrant. The shares of common stock or pre-funded warrants and the accompanying Series B warrants were sold
together but issued separately and were immediately separable upon issuance. Warrants to purchase 140,000 shares of common stock upon the exercise of
the underwriters’ over-allotment option and warrants to purchase 326,667 shares of common stock were issued to the underwriters as representatives of the
public offering. Net proceeds, after deducting underwriting discounts, commissions and offering expenses, were approximately $7,400,000.

Common stock issued for services

During the year ended December 31, 2020, the Company issued 16,667 fully vested shares of common stock for services rendered and recognized $49,350
in stock compensation expense related to these shares.

Warrants

A summary of the Company’s warrant activity is as follows:

December 31, 2018
Granted
Forfeitures
Expirations
Exercised
December 31, 2019
Granted
Forfeitures
Expirations
Exercised
December 31, 2020, all exercisable

Weighted
Average
Exercise
Price

Weighted
Average
Remaining
Contractual
Term (Years)

4.26   
2.52   
-   
(10.98)  
(3.00)  
2.28   
-   
-   
(9.00)  
(2.04)  
2.40   

0.29 
4.81 
- 
- 
- 
4.91 
- 
- 
- 
- 
3.81 

Shares

210,946    $

7,693,590   
-   
(46,572)  
(3,057,508)  
4,800,456   
-   
-   
(10,830)  
(2,656,868)  
2,132,758    $

F-19

 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The exercise prices of warrants outstanding and exercisable as of December 31, 2020 are as follows:

Warrants Outstanding and
Exercisable (Shares)

Exercise Prices

1,566,466    $
326,668   
173,334   
37,700   
28,590   
2,132,758   

2.05 
2.67 
3.00 
3.51 
17.25 

During the year ended December 31, 2019, the Company granted a total of 7,693,590 warrants consisting of: (a) 10,417 warrants associated with our IPO
financing in April 2019, (b) 18,173 warrants in connection with the conversion of certain notes (c) 2,831,667 warrants associated with our August public
offering, and (d) 4,833,334 warrants associated with our October public offering. No warrants were granted in the year ended December 31, 2020.

The August and October 2019 pre-funded warrants were sold to purchasers whose purchase of shares of common stock in the offerings would otherwise
result in the purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% of the Company’s outstanding common
stock  immediately  following  the  consummation  of  the  offerings,  in  lieu  of  shares  of  common  stock.  Each  pre-funded  warrant  represents  the  right  to
purchase one share of common stock at an exercise price of $0.01 per share.

The August 2019 public offering price was $2.64 per share of common stock and $0.01 per accompanying warrant. Each warrant sold with the shares of
common  stock  represents  the  right  to  purchase  one  share  of  common  stock  at  an  exercise  price  of  $3.51  per  share.  The  warrants  are  exercisable
immediately, expire five years from the date of issuance and provide that, beginning on the earlier of (i) 30 days from the effective date of the Registration
Statement and (ii) the date on which the Common Stock trades an aggregate of more than 6,666,667 shares after the announcement of the pricing of the
offering, and ending on the twelve month anniversary thereof, each warrant may be exercised at the option of the holder on a cashless basis at a ratio of one
warrant for one share of common stock, in whole or in part, if the weighted average price of the common stock on the trading day immediately prior to the
exercise date fails to exceed the initial exercise price of the warrant.

The October 2019 public offering price was $1.99 per share of common stock and $0.06 per accompanying warrant. Each warrant sold with the shares of
common stock represents the right to purchase one share of common stock at an exercise price of $2.05 per share.

During  the  year  ended  December  31,  2019,  investors  exercised  a  total  of  3,057,509  warrants  for  3,034,135  shares  of  common  stock,  consisting  of  (i)
2,559,384 warrants exercised on a cashless basis for 2,536,010 net common shares, and (ii) 498,125 warrants exercised for a total of $171,375 in proceeds
to the Company (450,000 of these warrants were exercisable for $0.06 per share, and 48,125 were exercisable for $3.00 per share).

During  the  year  ended  December  31,  2020,  investors  exercised  warrants  exercisable  into  2,656,868  shares  of  common  stock  for  total  proceeds  of
$5,451,892. The warrants were exercisable at $2.05 per share.

As  of  December  31,  2020,  the  Company  had  an  aggregate  of  2,132,758  outstanding  warrants  to  purchase  shares  of  its  common  stock.  The  aggregate
intrinsic value of warrants outstanding as of December 31, 2020 was $0.

F-20

 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
Stock Options

A summary of the Company’s stock option activity is as follows:

December 31, 2018
Granted
Forfeitures
Expirations
Exercised
December 31, 2019
Granted
Forfeitures
Expirations
Exercised
December 31, 2020, outstanding
December 31, 2020, exercisable

Shares

Weighted
Average
Exercise Price

Weighted
Average
Remaining
Contractual
Term (Years)

227,083    $
266,667   
-   
-   
-   
493,750   
423,333   
(138,889)  
-   
-   

778,194    $
500,764    $

13.56   
21.06   
-   
-   
-   
13.56   
5.58   
-   
-   
-   
9.48   
11.64   

3.78 
4.38 
- 
- 
- 
3.64 
9.51 
- 
- 
- 
6.38 
4.74 

The exercise prices of options outstanding and exercisable as of December 31, 2020 are as follows:

Options Outstanding
(Shares)

Options Exercisable
(Shares)

Exercise Prices

41,667   
5,000   
41,667   
1,667   
16,667   
375,000   
104,166   
10,416   
112,500   
69,445   
778,194   

41,667    $
5,000   
20,833   
1,667   
8,333   
126,738   
104,166   
10,416   
112,500   
69,445   
500,765   

1.48 
1.91 
2.34 
2.46 
3.24 
6.00 
12.00 
13.80 
15.00 
26.40 

The Company accounts for share-based payments in accordance with ASC 718 wherein grants are measured at the grant date fair value and charged to
operations over the vesting periods.

During the year ended December 31, 2020, the Company granted options to purchase 215,000 shares of common stock to six employees with a grant date
fair value determined to be $554,775 using a Black-Scholes option pricing model based on the following assumptions: (i) volatility rate of 141% to 147%,
(ii) discount rate of 0.18%, (iii) zero expected dividend yield, and (iv) expected life of 5.25 to 6 years. The options have an exercise price of $1.92 to $6.00
per  share.  Options  for  41,667  shares  vest  on  a  quarterly  basis  over  two  years  and  options  for  6,667  shares  vest  in  full  six  months  after  the  grant  date.
Options for 166,667 shares vest ratably over three years.

On June 30, 2020, the Company granted options to purchase 208,334 shares of common stock to the members of the Company’s Board of Directors with a
grant date fair value determined to be $478,735 using a Black-Scholes option pricing model based on the following assumptions: (i) volatility rate of 142%
to 148%, (ii) discount rate of 0.18%, (iii) zero expected dividend yield, and (iv) expected life of 5.25 years. The options have an exercise price of $6.00 per
share. The options vest on a quarterly basis over two years beginning three months after the grant date.

The  Company’s  volatility  is  based  on  an  average  volatility  of  similar  companies  in  the  same  industry.  The  risk-free  interest  rate  was  based  on  rates
established  by  the  Federal  Reserve  Bank.  The  expected  dividend  yield  was  based  on  the  fact  that  the  Company  has  not  paid  dividends  to  its  common
stockholders in the past and does not expect to pay dividends to its common stockholders in the future. The expected life of the stock options granted is
estimated using the “simplified” method, whereby the expected term equals the average of the vesting term and the original contractual term of the stock
option.

F-21

 
 
 
 
 
 
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
For  the  years  ended  December  31,  2020  and  2019,  the  Company  recognized  aggregate  stock-compensation  expense  of  $494,677  and  $2,593,730
respectively, related to the fair value of vested options.

As of December 31, 2020, the Company had an aggregate of 230,556 remaining unvested options outstanding, with a remaining fair value of $629,568 to
be  amortized  over  an  average  of  3.0  years,  weighted  average  exercise  price  of  $5.58,  and  weighted  average  remaining  life  of  9.3  years.  Based  on  the
closing price of the Company’s common stock on December 31, 2020 of $2.49, the aggregate intrinsic value of options outstanding as of December 31,
2020 was zero.

Settlement of stock options issued to former officer

In connection with a separation agreement entered into with Michael Favish, the Company’s former CEO (see Note 7), the expiration date of his vested
stock options was extended for twelve months from June 15, 2020. In accordance with ASC 718, the extension of the exercise period for the vested options
constitutes a modification of the original option agreement. In accounting for the modification, the Company calculated the fair value of the vested options
immediately before modification using current valuation inputs including the Company’s closing stock price of $2.94 on June 15, 2020, volatility of 142%,
and discount rate of 0.22%. The Company also calculated the fair value of the vested options immediately following the modification using the extended
12-month exercise period. An incremental stock compensation charge of $24,359 was recorded in costs related to resignation of former officer.

Mr. Favish’s unvested options of 138,889 at the time of his separation were forfeited. All compensation from prior periods related to these unvested options
was reversed, resulting in an adjustment to stock compensation expense during the year ended December 31, 2020 of $(965,295), which was recorded in
costs related to resignation of former officer.

11.

Income Taxes

Deferred  income  taxes  reflect  the  net  tax  effects  of  temporary  differences  between  the  carrying  amounts  of  assets  and  liabilities  for  financial  reporting
purposes and the amounts used for income tax purposes. Significant components of the Company’s deferred tax assets as of December 31, 2020 and 2019
are summarized below.

Net operating loss carryforwards
Stock-based compensation
Amortization of intangibles
Accrued expenses
Right of use
Research and development credit
Depreciation
Total deferred tax assets
Valuation allowance
Net deferred tax assets

December 31,

2020

2019

5,893,000    $
1,362,000   
106,000   
12,000   
(4,000)  
(13,000)  
(57,000)  
7,299,000   
(7,299,000)  

—    $

3,961,000 
1,479,000 
83,000 
12,000 
- 
(7,000)
(43,000)
5,485,000 
(5,485,000)
— 

$

$

In assessing the potential realization of deferred tax assets, management considers whether it is more likely than not that some portion or all of the deferred
tax assets will be realized. The ultimate realization of deferred tax assets is dependent upon the Company attaining future taxable income during the periods
in which those temporary differences become deductible. As of December 31, 2020, management was unable to determine if it is more likely than not that
the Company’s deferred tax assets will be realized and has therefore recorded an appropriate valuation allowance against deferred tax assets at such dates.

No federal tax provision has been provided for the years ended December 31, 2020 and 2019, due to the losses incurred during the periods. Reconciled
below is the difference between the income tax rate computed by applying the U.S. federal statutory rate and the effective tax rates for the years ended
December 31, 2020 and 2019:

U. S. federal statutory tax rate
State, net of federal benefit
Non-deductible goodwill impairment charge

Change in valuation allowance
Effective tax rate

F-22

Years Ended December 31,

2020

2019

(21.0)% 
(7.0)% 
-%  
(28.0)% 
28.0%  
0.0%  

(21.0)%
(7.0)%
3.0%
(25.0)%
25.0%
0.0%

 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
At December 31, 2020, the Company has available net operating loss carryforwards for federal income tax purposes of approximately $23,338,000 which,
if  not  utilized  earlier,  will  begin  to  expire  in  2035.  Due  to  restrictions  imposed  by  Internal  Revenue  Code  Section  382  regarding  substantial  changes  in
ownership of companies with loss carryforwards, the utilization of the Company’s NOLs may be limited as a result of changes in stock ownership.

The Company records a valuation allowance to reduce its deferred tax assets to the amount that is more likely than not to be realized. In the event the
Company determines that it would be able to realize its deferred tax assets in the future in excess of its recorded amount, an adjustment to the deferred tax
assets would be credited to operations in the period such determination was made. Likewise, should the Company determine that it would not be able to
realize  all  or  part  of  its  deferred  tax  assets  in  the  future,  an  adjustment  to  the  deferred  tax  assets  would  be  charged  to  operations  in  the  period  such
determination was made.

The Company is subject to U.S. federal income taxes and income taxes of various state tax jurisdictions. As the Company’s net operating losses have yet to
be utilized, all previous tax years remain open to examination by Federal authorities and other jurisdictions in which the Company currently operates or has
operated in the past. The Company had no unrecognized tax benefits as of December 31, 2020 and 2019 and does not anticipate any material amount of
unrecognized tax benefits within the next 12 months.

The Company accounts for uncertainty in income tax law under a comprehensive model for the financial statement recognition, measurement, presentation
and  disclosure  of  uncertain  tax  positions  taken  or  expected  to  be  taken  in  income  tax  returns  as  prescribed  by  GAAP. The  tax  effects  of  a  position  are
recognized only if it is “more-likely-than-not” to be sustained by the taxing authority as of the reporting date. If the tax position is not considered “more-
likely-than-not” to be sustained, then no benefits of the position are recognized. As of December 31, 2020, the Company had not recorded any liability for
uncertain tax positions. In subsequent periods, any interest and penalties related to uncertain tax positions will be recognized as a component of income tax
expense.

12.

Related Party Transactions

During  the  years  ended  December  31,  2020  and  2019,  the  Company  incurred  and  paid  $325,000  and  $300,000,  respectively,  of  salary  expense  to  our
former CEO, Michael Favish. During the years ended December 31, 2020 and 2019, the Company incurred and paid salaries of $75,000 and $114,000,
respectively, to Karen Favish, spouse of Michael Favish. During the years ended December 31, 2020 and 2019, the Company incurred and paid salaries of
$60,000 and $55,000, respectively, to Kristine Townsend, spouse of former Controller and Chief Accounting Officer John Townsend.

In December 2018, the Company had entered into an Employment Agreement (the “Agreement”) with Michael Favish, which agreement became effective
as of January 1, 2019. Pursuant to the Agreement, Mr. Favish was to serve in such positions for a term of three (3) years and following the expiration of
such three (3) year term, Mr. Favish’s employment was to be on an “at-will” basis, and such post-term employment will be subject to termination by either
party at any time, with or without cause or prior notice.

Pursuant to the terms of the Agreement, Mr. Favish was entitled to receive an annual base salary of $300,000 in 2019, $325,000 in 2020, and $350,000 in
2021. Effective June 15, 2020, Mr. Favish resigned as CEO of the Company and resigned from the Company’s Board of Directors. Terms of the settlement
agreement between the parties included the continuation of his previous salary of $325,000 during the twelve months subsequent to his resignation. The
$325,000  of  aggregated  settlement  payments  was  recorded  in  costs  related  to  resignation  of  former  officer  expense  in  the  accompanying  consolidated
statement  of  operations  for  the  year  ended  December  31,  2020.  As  of  December  31,  2020,  $148,958  of  the  settlement  amount  remains  payable  on  our
consolidated balance sheet and is payable through June 2021.

F-23

 
 
 
 
 
 
 
 
 
 
Dr.  Evans,  together  with  his  spouse,  wholly  owns  Ceatus  Media  Group  LLC,  a  California  limited  liability  company  (“Ceatus”),  founded  in  2004
specializing  in  digital  marketing  in  the  eye  health  care  sector.  The  Company  paid  Ceatus  $81,000  in  2019  and  $95,750  in  2020,  for  services  related  to
digital marketing for the Company.

Dr. Evans, together with his spouse, wholly owns DWT Evans LLC, an Ohio limited liability company (“DWT”), founded in 2000 which holds several
pieces of real estate. One of these holdings includes real property in Greenville, Ohio where the Company’s subsidiary, VectorVision Ocular Health, leases
office and warehouse space. The Company paid DWT rent in the amounts of $19,770 and $20,898 in 2020 and 2019 respectively.

When  the  Company  acquired  VectorVision,  it  also  acquired  AcQviz  from  Dr.  Evans,  which  is  a  patented  methodology  for  auto-calibrating  and
standardizing the testing light level for computer generated vision testing systems. Dr. Evans is entitled to receive a royalty on net revenue from AcQviz.
As part of the development of the CSV-2000, AcQviz was embedded in the product by Radiant Technologies, Inc. in exchange for a 3% royalty on the sales
of AcQviz. Radiant Technologies is owned by Joseph T. Evans, the brother of Dr. David Evans.

13.

Segment Reporting

The  Company  determined  its  reporting  units  in  accordance  with  ASC  280,  “Segment  Reporting”.  The  Company  currently  operate  in  two  reportable
segments: Medical Foods and Nutraceuticals and Medical Devices.

The Medical Foods and Nutraceuticals segment provides a portfolio of science-based, clinically supported nutrition, medical foods, and supplements. The
Medical Devices segment includes a portfolio of medical diagnostic devices currently focused on the ocular space and contrast testing. The Company’s
medical  devices  and  accessories  are  used  to  measure  visual  function  and  certain  anatomical  features  of  the  eye  that  detect  early  disease  and  monitor
changes over time.

The segments are based on the discrete financial information reviewed by the Chief Executive Officer, who is the Company’s Chief Operating Decision
Maker (“CODM”), to make resource allocation decisions and to evaluate performance. The reportable segments are each managed separately because they
manufacture  and  distribute  distinct  products  or  provide  services  with  different  processes.  All  reported  segment  revenues  are  derived  from  external
customers.

F-24

 
 
 
 
 
 
 
 
 
The accounting policies of the Company’s reportable segments are the same as those described in the summary of significant accounting policies (see Note
1). Certain corporate general and administrative expenses, including general overhead functions such as information systems, accounting, human resources,
Board  of  Director  fees,  corporate  legal  fees,  other  compliance  costs  and  certain  administrative  expenses,  as  well  as  interest  and  tax  expense,  are  not
allocated to the segments. The following tables set forth our results of operations by segment:

Revenue

Cost of goods sold

Gross profit (loss)

For the Year Ended December 31, 2020

Medical Foods
and

Corporate

Nutraceuticals     Medical Devices    

Total

$

4,500   

$

1,609,482    $

275,862    $

1,889,844 

2,478   

2,022   

1,599,510   

344,647   

1,946,635 

9,972   

(68,785)  

(56,791)

Stock compensation expense

544,127   

-   

-   

544,127 

Operating expenses

Loss from operations

3,757,945   

3,892,899   

299,969   

7,950,813 

$

(4,300,050)  

$

(3,882,927)   $

(368,754)   $

(8,551,731)

Revenue

Cost of goods sold

Gross profit

Stock compensation expense

Goodwill impairment charge

Operating expenses

Loss from operations

For the Year Ended December 31, 2019

Medical Foods
and

Corporate

Nutraceuticals     Medical Devices    

Total

$

24,270   

$

444,657    $

434,010    $

902,937 

7,288   

155,212   

178,815   

341,315 

16,982   

289,445   

255,195   

561,622 

2,717,731   

-   

-   

-   

-   

2,717,731 

1,563,520   

1,563,520 

360,257   

5,308,508   

1,108,543   

6,777,308 

$

(3,061,006)  

$

(5,019,063)   $

(2,416,868)   $

(10,496,937)

The following tables set forth our total assets by segment. Intersegment balances and transactions have been removed:

Current assets

Cash
Inventories, net
Other

Total current assets

Right of use asset
Property and equipment, net
Intangible assets, net
Other

Total assets

As of December 31, 2020

Medical Foods
and

Corporate

Nutraceuticals     Medical Devices    

Total

$

8,518,732   
-   
-   
8,518,732   

-   
-   
-   
-   

$

-    $

-    $

254,879   
89,333   
344,212   

374,447   
135,641   
50,000   
11,751   

130,093   
101,846   
231,939   

44,143   
150,035   
-   
-   

8,518,732 
384,972 
191,179 
9,094,883 

418,590 
285,676 
50,000 
11,751 

$

8,518,732   

$

916,051    $

426,217    $

9,860,900 

F-25

 
 
 
 
 
 
 
 
   
 
 
 
    
    
    
  
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
   
 
 
 
    
    
    
  
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
   
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
Current assets

Cash
Inventories, net
Other

Total current assets

Right of use asset
Property and equipment, net
Intangible assets, net
Other

Total assets

14.

Commitments and Contingencies

As of December 31, 2019

Medical Foods
and

Corporate

Nutraceuticals     Medical Devices    

Total

$

11,115,502   
5,003   
7,399   
11,127,904   

-   
-   
-   
-   

$

-    $

-    $

126,708   
219,223   
345,931   

509,464   
219,056   
50,000   
11,751   

179,230   
214,653   
393,883   

63,250   
155,582   
-   
-   

11,115,502 
310,941 
441,275 
11,867,718 

572,714 
374,638 
50,000 
11,751 

$

11,127,904   

$

1,136,202    $

612,715    $

12,876,821 

The Company is periodically the subject of various pending or threatened legal actions and claims arising out of its operations in the normal course of
business. In the opinion of management of the Company, adequate provision has been made in the Company’s financial statements at December 31, 2020
with respect to such matters. See notes 6,7, 11 and 13.

15.

Subsequent Events

The Company performed an evaluation of subsequent events through the date of filing of these consolidated financial statements with the SEC. Other than
those matters described below, there were no material subsequent events which affected, or could affect, the amounts or disclosures in the consolidated
financial statements.

Sale of common stock

On January 8, 2021, we entered into the Sales Agreement and filed a prospectus supplement pursuant to which we could sell up to $10,000,000 worth of
shares of our common stock in an “at the market” offering through the Distribution Agent (the “January 2021 1st ATM Offering”). On January 15, 2021, we
completed the January 2021 1st ATM Offering, pursuant to which we sold an aggregate of 2,559,833 shares of our common stock, raised gross proceeds of
approximately $10,000,000 and net proceeds of approximately $9,500,000.

On January 28, 2021, we entered into the Sales Agreement and filed a prospectus supplement pursuant to which we could sell up to $25,000,000 worth of
shares of our common stock in an “at the market” offering through the Distribution Agent (the “January 2021 2nd ATM Offering”). On February 10, 2021,
we  completed  the  January  2021  2nd  ATM  Offering,  pursuant  to  which  we  sold  an  aggregate  of  5,006,900  shares  of  our  common  stock,  raised  gross
proceeds of approximately $25,000,000 and net proceeds of approximately $24,100,000.

In addition, in January 2021 and February 2021, the Company issued an aggregate of 1,647,691 shares of common stock upon the exercise of warrants and
received $3,608,509.

The following table sets forth the Company’s assets, liabilities, and stockholders’ equity as December 31, 2020 on:

● an actual basis; and

● a pro forma basis giving effect to the January 2021 1st ATM Offering and January 2021 2nd ATM Offering as well as the exercise of warrants.

As of December 31, 2020

Cash and cash equivalents
Other current assets
Non-current assets
Total assets

Current liabilities
Non-current liabilities
Total liabilities

Stockholders’ equity:
Common stock
Additional paid-in capital
Accumulated deficit
Total stockholders’ equity
Total liabilities and stockholders’ equity

$

$

$

$

Actual

8,518,732    $
576,151   
766,017   
9,860,900    $

Pro Forma (unaudited)  
45,727,241 
576,151 
766,017 
47,069,409 

1,073,731    $
271,903   
1,345,634   

15,171   
62,583,423   
(54,083,328)  
8,515,266   
9,860,900    $

1,073,731 
271,903 
1,345,634 

24,427 
99,782,676 
(54,083,328)
45,723,775 
47,069,409 

The Company had a total of 15,170,628 shares of common stock (actual) and 24,426,993 shares of common stock (pro forma, which includes an addition
of 41,941 shares attributed to the reverse-split fractional share adjustment) issued and outstanding at December 31, 2020.

 
 
 
 
 
 
 
   
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
    
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
    
 
  
 
 
    
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Appointment of New CEO

Effective as of January 6, 2021, the Board of Directors appointed Bret Scholtes as President and Chief Executive Officer and as a director of the Company.

The Company and Mr. Scholtes entered into an employment pursuant to which Mr. Scholtes’s annual base salary is $400,000. The Employment Agreement
provides  that  Mr.  Scholtes  shall  have  an  annual  target  cash  bonus  opportunity  of  no  less  than  $400,000  (the  “Bonus”)  based  on  the  achievement  of
Company and individual performance objectives to be determined by the Board of Directors.

Mr.  Scholtes  was  granted  an  award  of  a  number  of  stock  options  equal  to  one  percent  (1%)  of  the  issued  and  outstanding  number  of  shares  of  the
Company’s common stock (the “Stock Options”) pursuant to the Company’s 2018 Equity Incentive Plan (the “Incentive Plan”), at an exercise price equal
to the closing price of the Company’s common stock on the Effective Date (152,671 shares, exercise price of $3.95 per share) . One third (1/3) of the Stock
Options  shall  vest  and  become  exercisable  the  first  anniversary  of  the  Effective  Date,  and  the  balance  of  the  Stock  Options  shall  vest  ratably  in  equal
installments  for  the  twenty-four  (24)  months  thereafter,  subject  to  continued  service,  and  shall  vest  in  full  upon  a  Change  in  Control  (as  defined  in  the
Incentive Plan). Additionally, the Company shall grant unvested shares of common stock in an amount equal to one percent (1%) of the number of shares
of Company common stock issued and outstanding on the Effective Date (the “Stock Grant”) to Mr. Scholtes under the Incentive Plan (152,671 shares).
The shares underlying the Stock Grant shall become vested in full on the first anniversary of the Effective Date. Additionally, Mr. Scholtes shall be granted
(i)  additional  stock  options  equal  to  two  percent  (2%)  of  the  Company’s  issued  and  outstanding  shares  of  common  stock  on  the  date  of  grant  if  the
Company  achieves  specified  written  performance  objectives  established  by  the  Board  for  the  Company’s  fiscal  years  ending  December  31,  2021  and
December 31, 2022 and (ii) additional stock options equal to either two percent (2%) or three percent (3%) of the Company’s issued and outstanding shares
of common stock on the date of grant if the Company meets certain financial objectives during the first five years following the Effective Date.

If Mr. Scholtes’s employment is terminated by the Company without cause (as defined in the Employment Agreement), if the Term expires after a notice of
non-renewal is delivered by the Company or if Mr. Scholtes’s employment is terminated following a change of control (as defined in the Incentive Plan),
Mr. Scholtes will be entitled to (a) twelve months’ base salary, (b) the prorated portion of the Bonus for the year in which the termination occurs, based on
actual performance and (c) base salary and benefits accrued through the date of termination.

F-26

 
 
 
 
 
INDEX TO EXHIBITS

Exhibit No.
3.1

Description
  Certificate of Incorporation in Delaware and amendment thereto (filed with the Registration Statement on Form S-1 filed with the SEC on

3.2
3.3

3.4

3.5

4.1*
10.1

10.2
10.3

10.4

10.5

10.6

10.7

10.8

10.9

21.1*
23.1*
31.1*
31.2*
32.1*

February 11, 2016)

  Certificate of Amendment to Certificate of Incorporation (filed on Form 8-K on February 1, 2019 and incorporated herein by reference)
  Certificate  of  Amendment  to  Certificate  of  Incorporation  filed  and  effective  with  the  Delaware  Secretary  of  State  on  December  6,  2019

(incorporated by reference to Exhibit 3.1 to the Company’s current report on Form 8-K, filed with the SEC on December 10, 2019)

  Second Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 to the Company’s current report on Form 8-K, filed with

the SEC on October 22, 2019)

  Second  Amended  and  Restated  Bylaws,  effective  October  22,  2019  (incorporated  by  reference  to  Exhibit  3.1  to  the  Company’s  current

report on Form 8-K, filed with the SEC on October 22, 2019)

  Description of Securities
  Lease for 15150 Avenue of the Sciences, Suite 200, San Diego California and amendments thereto (filed with the Registration Statement on

Form S-1 filed with the SEC on February 11, 2016)

  Form of Indemnification Agreement (filed with the Registration Statement on Form S-1 filed with the SEC on February 11, 2016)
  Intellectual Property Assignment Agreement with David W. Evans and VectorVision, Inc. dated as of September 29, 2017 (filed on Form 8-

K on October 5, 2017 and incorporated herein by reference)

  Consulting Agreement with David W. Evans dated as of September 29, 2017 (filed on Form 8-K on October 5, 2017 and incorporated herein

by reference)

  Guardion Health Sciences, Inc. 2018 Equity Incentive Plan (filed with the Definitive Proxy Statement on Schedule 14A on October 22, 2018

and incorporated herein by reference)

  Warrant  Agreement,  including  form  of  Warrant,  made  as  of  August  15,  2019,  between  the  Company  and  VStock  Transfer  LLC

(incorporated by reference to Exhibit 10.3 to the Company’s current report on Form 8-K, filed with the SEC on August 19, 2019)

  Warrant Agreement, including form of Series B Warrant, made as of October 30, 2019, between the Company and VStock (incorporated by

reference to Exhibit 10.1 to the Company’s current report on Form 8-K, filed with the SEC on October 31, 2019)

  Employment  Agreement,  by  and  between  the  Company  and  Andrew  C.  Schmidt  (incorporated  by  reference  to  Exhibit  10.1  to  the

Company’s current report on Form 8-K, filed with the SEC on July 23, 2020)

  Employment  Agreement,  by  and  between  the  Company  and  Bret  Scholtes  (incorporated  by  reference  to  Exhibit  10.1  to  the  Company’s

current report on Form 8-K, filed with the SEC on December 29, 2020)

  List of Subsidiaries
  Consent of Weinberg & Company
  Certification of Principal Executive Officer under Section 302 of the Sarbanes-Oxley Act of 2002.
  Certification of Principal Accounting and Financial Officer under Section 302 of the Sarbanes-Oxley Act of 2002.
  Certification of the Principal Executive Officer and the Principal Accounting and Financial Officer under Section 906 of the Sarbanes-Oxley

Act of 2002.

* filed herewith

65

 
 
 
 
 
 
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this Report to be signed on its
behalf by the undersigned, thereunto duly authorized on the 26th day of March 2021.

SIGNATURES

GUARDION HEALTH SCIENCES, INC.

/s/ Bret Scholtes

By:
Name: Bret Scholtes
Title: Chief Executive Officer

POWER OF ATTORNEY

We, the undersigned officers and directors of GUARDION HEALTH SCIENCES, INC., hereby severally constitute and appoint Bret Scholtes and Andrew
Schmidt, and each of them (with full power to each of them to act alone), our true and lawful attorneys-in-fact and agents, with full power of substitution,
for us in any and all capacities, to sign any amendments to this Form 10-K, and to file the same, with exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their
substitute or substitutes, may lawfully do or cause to be done by virtue thereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, this Report has been signed by the following persons in the capacities and on the
dates indicated.

Signature

/s/ Bret Scholtes
Bret Scholtes

/s/ Andrew Schmidt
Andrew Schmidt

/s/ Robert N. Weingarten
Robert N. Weingarten

/s/ Mark Goldstone
Mark Goldstone

/s/ David W. Evans
David W. Evans

/s/ Donald A. Gagliano
Donald A. Gagliano

/s/ Kelly Anderson
Kelly Anderson

Title

Date

  CEO, President and
  Director (Principal Executive Officer)

  March 26, 2021

  Chief Financial Officer
  Officer (Principal Financial and Principal Accounting

  March 26, 2021

Officer)

  Director

  Director

  Director

  Director

  Director

66

  March 26, 2021

  March 26, 2021

  March 26, 2021

  March 26, 2021

  March 26, 2021

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DESCRIPTION OF THE REGISTRANT’S SECURITIES
REGISTERED PURSUANT TO SECTION 12 OF THE
SECURITIES EXCHANGE ACT OF 1934

EXHIBIT 4.1

As  of  March  25,  2021,  Guardion  Health  Sciences,  Inc.  (“the  Company”)  had  one  class  of  securities  registered  under  Section  12  of  the  Securities

Exchange Act of 1934, as amended (the “Exchange Act”)—our common stock, par value $0.001 per share (“Common Stock”).

Description of Common Stock

The following description of our Common Stock is a summary and does not purport to be complete. It is subject to and qualified in its entirety by
reference  to  our  Certificate  of  Incorporation,  as  amended  (the  “Certificate  of  Incorporation”)  and  our  Bylaws  (the  “Bylaws”),  each  of  which  are
incorporated by reference as an exhibit to the Annual Report on Form 10-K of which this Exhibit 4.2 is a part. We encourage you to read our Certificate of
Incorporation, Bylaws, and the applicable provisions of the Delaware General Corporation Law for additional information.

Authorized Capital Shares

Our authorized capital shares consist of 250,000,000 shares of Common Stock, $0.001 par value per share, and 10,000,000 shares of preferred stock,
$0.001 par value per share (“Preferred Stock”). As of March 25, 2021, there were 24,426,993 shares of Common Stock issued and outstanding. There were
no shares of Preferred Stock issued or outstanding as of March 25, 2021.

Voting Rights

Holders  of  Common  Stock  are  entitled  to  one  vote  per  share  on  all  matters  voted  on  by  the  stockholders,  including  the  election  of  directors.  Our

Certificate of Incorporation and Bylaws do not provide for cumulative voting in the election of directors.

Dividend Rights

Holders of Common Stock are entitled to receive dividends, if any, as may be declared from time to time by the Board of Directors (“Board”) in its
discretion  out  of  funds  legally  available  for  the  payment  of  dividends  subject  to  the  prior  rights  of  holders  of  Preferred  Stock  and  any  contractual
restrictions we have against the payment of dividends on Common Stock.

Liquidation Rights

In the event of our liquidation, the holders of our Common Stock will be entitled to share ratably in any distribution of our assets after payment of all

debts and other liabilities and the preferences payable to holders of shares of Preferred Stock then outstanding, if any.

Applicable Anti-Takeover Provisions

Set forth below is a summary of the provisions of the Certificate of Incorporation and the Bylaws that could have the effect of delaying or preventing a
change  in  control  of  the  Company.  The  following  description  is  only  a  summary  and  it  is  qualified  by  refence  to  the  Certificate  of  Incorporation,  the
Bylaws and relevant provisions of the Delaware General Corporation Law (“DGCL”).

-1-

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Ability of Stockholders to Call Special Meetings

Our  Certificate  of  Incorporation  and  Bylaws  provide  that  stockholders  can  only  call  a  special  meeting  if  stockholders  holding  over  50%  of  all

issued and outstanding shares of the Corporation entitled to vote at a meeting do so.

Advance Notice Requirements

Our  Bylaws  establish  advance  notice  procedures  with  regard  to  stockholder  proposals  relating  to  the  nomination  of  candidates  for  election  as
directors or new business to be brought before meetings of stockholders. These procedures provide that notice of such stockholder proposals must be timely
given  in  writing  to  the  Secretary  of  the  Company  prior  to  the  meeting  at  which  the  action  is  to  be  taken.  The  notice  must  contain  certain  information
specified in our Bylaws.

Blank Check Preferred Stock

Our  Certificate  of  Incorporation  provides  for  10,000,000  authorized  shares  of  “blank  check”  preferred  stock,  the  terms  of  which  may  be
determined  by  our  board  of  directors  without  obtaining  stockholder  approval.  Undesignated  or  “blank  check”  preferred  stock  may  enable  our  board  of
directors to render more difficult or to discourage an attempt to obtain control of us by means of a tender offer, proxy contest, merger or otherwise, and to
thereby protect the continuity of our management.

Exclusive Forum Provision

In accordance with an exclusive forum provision set forth in the Bylaws, unless the Company consents in writing to the selection of an alternative
forum, the Court of Chancery of the State of Delaware shall be the sole and exclusive forum for (a) any derivative action or proceeding brought on behalf
of  the  Company,  (b)  any  action  asserting  a  claim  of  breach  of  a  fiduciary  duty  owed  by  any  director,  officer  or  other  employee  of  the  Company  to  the
Company or the Company’s stockholders, (c) any action asserting a claim arising pursuant to any provision of the Delaware General Corporation Law, or
(d) any action asserting a claim governed by the internal affairs doctrine.

Listing

The Common Stock is traded on NASDAQ Global Market under the trading symbol “GHSI”.

Transfer Agent

The Company’s transfer agent is VStock Transfer, LLC.

-2-

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
LIST OF SUBSIDIARIES

EXHIBIT 21.1

Name

  State or Other Jurisdiction of Incorporation

VectorVision Ocular Health, Inc.
Transcranial Doppler Solutions, Inc.
NutriGuard Formulations, Inc.

  Delaware
  Delaware
  Delaware

 
 
 
 
 
 
 
 
 
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statements on Forms S-1 (No. 333-232544, No. 333-234322 and No. 333-233067), Form
S-3  (No.  333-248895),  and  Form  S-8  (No.  333-231603)  of  Guardion  Health  Sciences,  Inc.  of  our  report  dated  March  26,  2021,  with  respect  to  the
consolidated financial statements of Guardion Health Sciences, Inc. of December 31, 2020 and 2019, and for the years then ended, included in this Annual
Report on Form 10-K for the year ended December 31, 2020.

EXHIBIT 23.1

/s/ Weinberg & Company, P.A.
Los Angeles, California
March 26, 2021

 
 
 
 
 
 
 
EXHIBIT 31.1

I, Bret Scholtes, certify that:

1.

I have reviewed this annual report on Form 10-K of Guardion Health Sciences, Inc;

CERTIFICATION

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements  made,  in  light  of  the  circumstances  under  which  such  statements  were  made,  not  misleading  with  respect  to  the  period  covered  by  this
report;

3. Based on  my  knowledge,  the  financial  statements,  and  other  financial  information  included  in  this  report,  fairly  present  in  all  material  respects  the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s  other  certifying  officer(s)  and  I  are  responsible  for  establishing  and  maintaining  disclosure  controls  and  procedures  (as  defined  in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the registrant and have:

(a) Designed such  disclosure  controls  and  procedures,  or  caused  such  disclosure  controls  and  procedures  to  be  designed  under  our  supervision,  to
ensure  that  material  information  relating  to  the  registrant,  including  its  consolidated  subsidiaries,  is  made  known  to  us  by  others  within  those
entities, particularly during the period in which this report is being prepared;

(b) Designed  such  internal  control  over  financial  reporting,  or  caused  such  internal  control  over  financial  reporting  to  be  designed  under  our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles;

(c) Evaluated  the  effectiveness  of  the  registrant’s  disclosure  controls  and  procedures  and  presented  in  this  report  our  conclusions  about  the

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in  this  report  any  change  in  the  registrant’s  internal  control  over  financial  reporting  that  occurred  during  the  registrant’s  most recent
fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially
affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the

registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably

likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control

over financial reporting.

Date: March 26, 2021

/s/ Bret Scholtes
Bret Scholtes
Chief Executive Officer
(Principal Executive Officer)

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
EXHIBIT 31.2

I, Andrew Schmidt, certify that:

1.

I have reviewed this annual report on Form 10-K of Guardion Health Sciences, Inc;

CERTIFICATION

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements  made,  in  light  of  the  circumstances  under  which  such  statements  were  made,  not  misleading  with  respect  to  the  period  covered  by  this
report;

3. Based on  my  knowledge,  the  financial  statements,  and  other  financial  information  included  in  this  report,  fairly  present  in  all  material  respects  the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s  other  certifying  officer(s)  and  I  are  responsible  for  establishing  and  maintaining  disclosure  controls  and  procedures  (as  defined  in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the registrant and have:

(a) Designed such  disclosure  controls  and  procedures,  or  caused  such  disclosure  controls  and  procedures  to  be  designed  under  our  supervision,  to
ensure  that  material  information  relating  to  the  registrant,  including  its  consolidated  subsidiaries,  is  made  known  to  us  by  others  within  those
entities, particularly during the period in which this report is being prepared;

(b) Designed  such  internal  control  over  financial  reporting,  or  caused  such  internal  control  over  financial  reporting  to  be  designed  under  our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles;

(c) Evaluated  the  effectiveness  of  the  registrant’s  disclosure  controls  and  procedures  and  presented  in  this  report  our  conclusions  about  the

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in  this  report  any  change  in  the  registrant’s  internal  control  over  financial  reporting  that  occurred  during  the  registrant’s  most recent
fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially
affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the

registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably

likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control

over financial reporting.

Date: March 26, 2021

/s/ Andrew Schmidt
Andrew Schmidt
Chief Financial Officer
(Principal Financial and Principal Accounting Officer)

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CERTIFICATIONS PURSUANT TO
18 U.S.C. SECTION 1350,
AS ENACTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

EXHIBIT 32.1

In connection with the Annual Report of Guardion Health Sciences, Inc. (the “Company”) on Form 10-K for the period ended December 31, 2020 as filed
with  the  Securities  and  Exchange  Commission  on  the  date  hereof  (the  “Report”),  each  of  Bret  Scholtes,  Chief  Executive  Officer  of  the  Company,  and
Andrew Schmidt, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. § 1350, as enacted pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The  information  contained  in  the  Report  fairly  presents,  in  all  material  respects,  the  financial  condition  and  results  of  operations  of  the

Company.

March 26, 2021

March 26, 2021

/s/ Bret Scholtes
Bret Scholtes
Chief Executive Officer
(Principal Executive Officer)

/s/ Andrew Schmidt
Andrew Schmidt
Chief Financial Officer
(Principal Financial and Principal Accounting Officer)