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Integra LifeSciences Holdings Corporation

iart · NASDAQ Healthcare
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FY2022 Annual Report · Integra LifeSciences Holdings Corporation
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549

FORM 10-K

(Mark One)
☒

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

☐

TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF
1934

For the fiscal year ended December 31, 2022
 or

For the transition period from              to             

COMMISSION FILE NO. 000-26224

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
(EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

Delaware
(STATE OR OTHER JURISDICTION OF
INCORPORATION OR ORGANIZATION)

1100 Campus Road
Princeton , New Jersey
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)

51-0317849
(I.R.S. EMPLOYER
IDENTIFICATION NO.)

08540

(ZIP CODE)

REGISTRANT’S TELEPHONE NUMBER, INCLUDING AREA CODE: (609) 275-0500

Title of Each Class
Common Stock, Par Value $.01 Per Share

Trading Symbol
IART

Name of Exchange on Which Registered
Nasdaq Global Select Market

SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT: 

SECURITIES REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT:

NONE

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes  ☒    No  ☐

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act. Yes  ☐

 No  ☒

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding
12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days.    Yes  ☒    No  ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T
(§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes  ☒    No  ☐

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth
company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
(Check one):

Large accelerated filer

Non-accelerated filer

Emerging growth company

☒

☐

☐

Accelerated filer

Smaller reporting company

☐

☐

If an emerging growth company, indicate by check if the registrant has elected not to use the extended transition period for complying with any new revised financial
accounting standards provided pursuant to Section 13(a) of the Exchange Act.   ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial
reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☒

If  securities  are  registered  pursuant  to  Section  12(b)  of  the  Act,  indicate  by  check  mark  whether  the  financial  statements  of  the  registrant  included  in  the  filing  reflect  the
correction of an error to previously issued financial statements. ☐

Indicate  by  check  mark  whether  any  of  those  error  corrections  are  restatements  that  required  a  recovery  analysis  of  incentive-based  compensation  received  by  any  of  the
registrant’s executive officers during the relevant recovery period pursuant to § 240.10D-1(b). ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ☐ No  ☒

As of June 30, 2022, the aggregate market value of the registrant’s common stock held by non-affiliates was approximately $3,916.0 million based upon the closing sales price
of the registrant’s common stock on The Nasdaq Global Select Market on such date. The number of shares of the registrant’s Common Stock, $0.01 par value, outstanding as of
February 21, 2023 was 81,636,066.

Certain portions of the registrant’s definitive proxy statement relating to its scheduled May 12, 2023 Annual Meeting of Stockholders, which will be filed with the Securities
and Exchange Commission, are incorporated by reference in Part III of this Annual Report on Form 10-K.

DOCUMENTS INCORPORATED BY REFERENCE:

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INTEGRA LIFESCIENCES HOLDINGS CORPORATION
TABLE OF CONTENTS 

Page

PART I

           Item 1. Business
           Item 1A. Risk Factors
           Item 1B. Unresolved Staff Comments
           Item 2. Properties
           Item 3. Legal Proceedings
           Item 4. Mine Safety Disclosures

PART II
            Item 5. Market for Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
            Item 6. [Reserved]
            Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations
            Item 7A. Quantitative and Qualitative Disclosures About Market Risk
            Item 8. Financial Statements and Supplementary Data
            Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosures
            Item 9A. Controls and Procedures
            Item 9B. Other Information
            Item 9C. Disclosure Regarding Foreign Jurisdictions that Prevent Inspections
PART III
            Item 10. Directors, Executive Officers and Corporate Governance
            Item 11. Executive Compensation
            Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
            Item 13. Certain Relationships, Related Transactions, and Director Independence
            Item 14. Principal Accountant Fees and Services
PART IV

            Item 15. Exhibits and Financial Statements Schedule
            Item 16. Form 10-K Summary

SIGNATURES

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ITEM 1. BUSINESS

OVERVIEW

PART I

The terms “we,” “our,” “us,” “Company,” "Integra LifeSciences," and “Integra” refer to Integra LifeSciences Holdings Corporation, a Delaware corporation,
and its subsidiaries, unless the context suggests otherwise.

Integra LifeSciences is a global leader in regenerative tissue technologies and neurological solutions dedicated to limiting uncertainty for clinicians so they
can focus on providing the best patient care. Founded in 1989 with the acquisition of an engineered collagen technology platform used to repair and
regenerate tissue, Integra LifeSciences Holdings Corporation common stock trades on the Nasdaq Global Select Market (“Nasdaq”) under the symbol
“IART.” Integra has developed numerous product lines from this technology for applications ranging from burn and deep tissue wounds to the repair of dura
mater in the brain, as well as nerves and tendons. The Company has expanded its base regenerative technology business to include surgical instruments,
neurosurgical products and advanced wound care through global acquisitions and product development to meet the evolving needs of its customers and
enhance patient care.

Integra products are sold in more than 130 countries through a direct sales force as well as distributors and wholesalers. We manufacture and sell medical
technologies  and  products  in  two  reportable  business  segments:  Codman  Specialty  Surgical  ("CSS")  and  Tissue  Technologies  ("TT").  The  CSS  segment,
which  represents  approximately  two-thirds  of  our  total  revenue,  consists  of  market-leading  technologies  and  instrumentation  used  for  a  wide  range  of
specialties,  such  as  neurosurgery,  neurocritical  care  and  otolaryngology.  We  are  the  world  leader  in  neurosurgery  and  one  of  the  top  three  providers  in
instruments used in precision, specialty, and general surgical procedures. Our TT segment generates about one-third of our overall revenue and focuses on
three main areas: complex wound surgery, surgical reconstruction, and peripheral nerve repair.

We have key manufacturing and research facilities located in California, Indiana, Maryland, Massachusetts, New Jersey, Ohio, Puerto Rico, Tennessee, Utah,
France, Germany, Ireland and Switzerland. We source most of our handheld surgical instruments and dural sealant products through specialized third-party
vendors.

Vision

We aspire to continue to be a worldwide leader in neurosurgery and reconstructive surgery with a portfolio of leading businesses that delivers outstanding
customer experiences through innovation, execution and teamwork to positively impact the lives of millions of patients and their families.

Strategy

Integra is committed to delivering high quality products that positively impact the lives of millions of patients and their families. We focus on four key pillars
of  our  strategy:  1)  enabling  an  execution-focused  culture,  2)  optimizing  relevant  scale,  3)  advancing  innovation  and  agility,  and  4)  leading  in  customer
experience. We believe that by sharpening our focus on these areas through improved planning and communication, optimization of our infrastructure, and
strategically aligned acquisitions, we can build scale, increase competitiveness and achieve our long-term goals.

To this end, the executive leadership team has established the following key priorities aligned to the following areas of focus:

Strategic Acquisitions. An important part of the our strategy is pursuing strategic transactions and licensing agreements that increase relevant scale in the
clinical areas in which Integra competes. Our growth strategy includes the acquisition of businesses, assets or products lines to increase the breadth of our
offerings, the reach of our product portfolios and drive relevant scale to our customers. On December 6, 2022, the Company completed the acquisition of
Surgical Innovation Associates, Inc. ("SIA"), which develops, markets and sells DuraSorb®, a resorbable synthetic matrix for plastic and reconstructive
surgery. This acquisition will advance Integra’s global strategy in breast reconstruction, expanding plans to access the U.S. market where SIA is pursuing pre-
market approval for use in implant-based breast reconstruction ("IBBR"). We also continued to expand our product offering of regenerative technologies from
our 2021 acquisition of ACell, Inc. ("ACell"), an innovative regenerative medicine company specializing in the manufacturing of porcine urinary bladder
extracellular matrices. See Note 4, Acquisitions and Divestitures, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on
Form 10-K) for additional details.

New Product Introductions and Portfolio Optimization. We are investing in innovative product development to drive a multi-generational pipeline for our key
product  franchises.  Our  product  development  efforts  span  across  our  key  global  franchises  focused  on  potential  technological  innovations  for  significant
returns on investment. In addition to new product development, we are funding studies to gather clinical evidence to support launches, ensure market access
and improve reimbursement for existing products. In addition to acquisitions and organic reinvestment, we continually look to optimize our portfolio towards
higher growth and higher margin businesses.

As  such,  we  may  opportunistically  divest  businesses  or  discontinue  products  where  we  see  limited  runway  for  future  value  creation  in  line  with  our
aspirations due in part to changes in the market, business fundamentals or the regulatory environment.

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In  August  2022,  we  completed  the  sale  of  our  non-core  traditional  wound  care  ("TWC")  business  to  Gentell,  LLC  ("Gentall")  for  $28.8  million,  which
consists  of  $27.8  million  in  cash  plus  $1.0  million  in  contingent  consideration  which  may  be  received  upon  the  achievement  of  certain  revenue-based
performance  milestones.  In  January  2021,  we  completed  the  sale  of  our  Extremity  Orthopedics  business  to  Smith  &  Nephew  USD  Limited  ("Smith  &
Nephew"),  a  subsidiary  of  Smith  &  Nephew  plc,  for  approximately $240 million  in  cash.  Our  portfolio  optimization  actions  over  the  past  two  years  have
allowed us to increase our focus on Integra’s core portfolio of market-leading products in neurosurgery, surgical instrumentation and regenerative tissue and
moves us closer to achieving our long-term organic growth and profitability targets. See Note 4, Acquisitions and Divestitures, to the Notes to Consolidated
Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for additional details.

Commercial Channel Investments. Investing in our sales channels is a core part of our strategy to create specialization and greater focus on reaching new and
existing customers and addressing their needs. To support our commercial efforts in Tissue Technologies, we utilize a two-tier specialist model to increase our
presence  in  focused  segments  to  help  serve  the  evolving  needs  of  our  customers.  In  addition,  we  continue  to  build  upon  our  leadership  brands  across  our
product franchises in both CSS and TT to engage customers through enterprise-wide contracts with leading hospitals, integrated delivery networks and global
purchasing  organizations  in  the  United  States.  Internationally,  we  have  increased  our  commercial  resources  significantly  in  key  emerging  markets  and  are
making investments to support our sales organization and maximize our commercial opportunities. Domestically, we have also increased our TT sales force in
the  United  States  to  support  the  expanded  regenerative  tissue  product  portfolio  that  includes  ACell  products.  These  investments  in  our  international  and
domestic sales channel position us well for expansion and long-term growth.

Customer Experience. We aspire to be ranked as a best-in-class provider and are committed to strengthening our relationships with all customers. We continue
to invest in technologies, systems and processes to enhance the customer experience. In 2022, we outsourced certain transactional back-office finance and
customer  service  activities  to  enhance  customer  quality,  build  scale  for  future  growth,  and  capture  cost  efficiencies.  We  also  launched  digital  tools  and
programs, resources and virtual product training to drive continued customer familiarity with our growing portfolio of medical technologies globally. .

BUSINESS SEGMENTS

Integra currently manufactures and sells our products and technologies in the following two global reportable business segments: Codman Specialty Surgical
and  Tissue  Technologies.  We  include  financial  information  regarding  our  reportable  business  segments  and  certain  geographic  information  under  "Item  7.
Management's Discussion and Analysis of Financial Condition and Results of Operations" and Note 16, Segment and Geographic Information to the Notes to
Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K).

Codman Specialty Surgical

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The  Codman  Specialty  Surgical  business  consists  of  a  broad  portfolio  of  market-leading  brands,  such  as  Codman ,  DuraGen ,  DuraSeal ,  CUSA ,
Mayfield ,Bactiseal ,  and  Certas Plus,which  are  used  for  the  management  of  multiple  disease  states,  including  brain  tumors,  traumatic  brain  injury,
hydrocephalus and other neurological conditions. The growth in this business in the recent years has been fueled by geographic expansion and new product
registrations in markets, such as China, Japan, and Europe, which we expect to continue in the near-to-long term.

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In 2022, we made progress to several enhancements to our CUSA Clarity Tissue Ablation System. The extended laparoscopic tip was launched in the U.S. to
enhance laparoscopic liver procedures. In addition, a single-sided bone tip received 510(k) clearance. Commercial launch is expected in the first quarter of
2023. We continue to update our CUSA Clarity platform by incorporating new ultrasonic handpiece and integrated electrosurgical capabilities.

Moreover,  we  are  expanding  into minimally  invasive  surgery  ("MIS")  and  the  surgical  management  of  intracerebral  hemorrhages  ("ICH"),  with  the  2021
clinical  launch  of  Aurora  Surgiscope ,  a  proprietary  surgical  solution  with  integrated  visualization  and  capabilities  designed  specifically  for  use  in deep-
seated brain lesions. We continue to gather clinical evidence using this same technology for early surgical intervention of ICH. We believe this technology
offers the promise of transforming the standard of care in neurosurgery. In 2022, we launched the Aurora  Evacuator with Coagulation device in the U.S.,
designed to be used in conjunction with our Aurora Surgiscope to safely address and evacuate blood in the brain caused by hemorrhagic stroke. 

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Rounding  out  the  portfolio  is  a  catalog  of  surgical  headlamps  and  surgical  instrumentation,  as  well  as  after-market  service.  With  thousands  of  surgical
instrument  products,  including  specialty  surgical  instruments,  we  call  on  the  central  sterile  processing  unit  of  hospitals  and  acute  care  surgical  centers.
Additionally, through a strong U.S. distribution model, we serve the needs of hundreds of medical offices.

We  also  expanded  our  product  offerings  in  2021  with  the  launch  of  our  new  intracranial  pressure  ("ICP")  monitoring  system,  CereLink   in  the  U.S.  and
Europe  and  continued  the  global  rollout  in  the  first  half  of  2022.  See  additional  discussion  regarding  certain  matters  with  CereLink under  "Item  1A.  Risk
Factors" under the heading Risks Related to our Regulatory Environment

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and under "Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations - General - FDA Matters" of this Annual Report
on Form 10-K.

Our global commercial network includes clinical specialists, a large direct global sales force and strategic partnerships and distributors that serve hospitals,
integrated health networks, group purchasing organizations, clinicians, surgery centers and health care providers.

Tissue Technologies

The Tissue Technologies segment consists of five unique regenerative technology areas - highly engineered bovine collagen, bovine dermis, porcine urinary
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bladder, human amniotic tissue, and resorbable synthetic mesh. This broad regenerative platform, which includes multiple leading brands such as Integra
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Dermal Matrices, AmnioExcel , SurgiMend , MicroMatrix  and NeuraGen , primarily addresses the needs of plastic, reconstructive and general surgeons
focused on the treatment of acute wounds, such as burns, chronic wounds, including diabetic foot ulcers, and surgical tissue repair, such as hernia, tendon,
peripheral nerve repair and protection. During 2022, we completed the acquisition of Surgical Innovation Associates, Inc. ("SIA"), which is seeking approval
by the U.S Food and Drug Administration ("FDA") of the PMA application for its core technology, DuraSorb, for use in IBBR.

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We have a specialized sales organization composed of directly employed sales representatives, as well as specialty distributors, organized based upon their
call  point.  Our  wound  reconstruction  sales  representatives  call  on  surgeons  doing  procedures  in  limb  salvage,  trauma,  wound  reconstruction  and  burns,
chronic  wounds  primarily  in  the  inpatient  wound  care  clinic  setting.  We  also  have  a  dedicated  surgical  reconstruction  sales  team  focused  on  plastic  and
reconstructive surgery and hernia procedures with differentiated products. Finally, we have a distributor network focused on biologics. Outside the U.S., we
have a combination of direct and indirect sales channels in international markets to sell certain product lines.

This  business  segment  also  includes  private-label  sales  of  a  broad  set  of  our  regenerative  and  wound  care  technologies.  Our  customers  are  other  medical
technology companies that sell to end markets primarily in spine, surgical and wound care.

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We  anticipate  new  product  introductions  and  new  clinical  indications  will  continue  to  contribute  to  the  growth  of  the  segment.  In  2022,  we  launched
NeuraGen  3D Nerve Guide Matrix, a resorbable implant for repair of peripheral nerve discontinuities and engineered to create an optimized environment for
nerve regeneration. In the third quarter of 2021, we filed the PMA application for a specific indication for SurgiMend in the use of post-mastectomy breast
reconstruction, for which we hope to obtain FDA approval in 2024.

COMPETITION

Our competitors for CSS are Medtronic, Inc., Stryker Corporation, Becton Dickinson and Company, and B. Braun Medical, Inc. In addition, we compete with
many smaller specialized companies and larger companies that do not otherwise focus on the offerings of Codman Specialty Surgical technologies. We rely
on the depth and breadth of our sales and marketing organization, our innovative technologies, and our procurement and manufacturing operations to maintain
our competitive position.

Our competition for TT includes Smith & Nephew plc, Organogenesis Holdings Inc., MiMedx Group, Inc., Allergan PLC, Becton Dickinson and Company,
and Axogen, Inc. We compete with many additional companies who partially participate in soft tissue reconstruction of complex wounds, peripheral nerve
repair and surgical reconstruction. In addition, our products also compete against medical practices that treat a condition without using a medical device or
any particular product, such as medical practices that utilize autograft tissue instead of our dermal regeneration products, duraplasty products and nerve repair
products.  Depending  on  the  product  line,  we  compete  based  on  our  products'  features,  strength  of  our  sales  force  or  distributors,  sophistication  of  our
technology and cost effectiveness of our solution.

RESEARCH AND DEVELOPMENT STRATEGY

Our research and development activities focus on identifying unmet surgical needs and addressing those needs with innovative solutions and products. We
apply our core competency in regenerative technology to innovate products for neurosurgical, wound applications, plastic surgery, and reconstructive surgery
and we have extensive R&D development programs for our core platforms of electromechanical technologies. Additionally, we conduct products and clinical
studies to generate efficacy and health economic evidence.

Regenerative Technologies. Integra  was  the  first  company  to  receive  a  FDA  claim  for  regeneration  of  dermal  tissue  and  is  a  world  leader  in  regenerative
technology. Because regenerative technology products represent a fast-growing, high-margin opportunity for us, we allocate a large portion of our research
and  development  budget  to  these  projects.  Our  regenerative  technology  development  program  applies  our  expertise  in  bioengineering  to  a  range  of
biomaterials including natural materials such as purified collagen, intact human or animal tissues, honey as well as resorbable synthetic polymers with our
DuraSorb and DuraSeal product  lines.  These  unique  product  designs  are  used  for  neurosurgical  and  reconstructive  surgical  applications,  as  well  as  dermal
regeneration, including the healing of chronic and acute wounds, tendon and nerve repair. Our regenerative

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technology platform includes our legacy Integra  Dermal Regeneration Template ("IDRT") products and complementary technologies that we have acquired.
Our  collagen  manufacturing  capability,  combined  with  our  history  of  innovation,  including  our  launch  of  NeuraGen  3D,  provides  us  with  strong  platform
technologies for multiple indications.

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In 2020, we announced positive clinical and economic data on Integra  Bilayer Wound Matrix ("IBWM") in complex lower extremity reconstruction based on
two  retrospective  studies  recently  published  in  Plastic  and  Reconstructive  Surgery,  the  official  journal  of  the  American  Society  of  Plastic  Surgeons.  As
surgeons look for ways to efficiently and effectively repair and close wounds, IBWM helps address the efficiency needed in operating rooms by reducing both
the operating time and costs to hospitals and patients. In 2021, we completed one of the largest diabetic foot ulcers ("DFU"), randomized controlled trials of
the PriMatrix  Dermal Repair Scaffold for the management of DFU. This multi-center study enrolled more than 225 patients with chronic DFU's over the
course of 12-week treatments and 4-week follow-up phases. The results of this study, which was published in the Journal of Wound Care, demonstrated that
PriMatrix plus standard of care ("SOC") consisting of sharp debridement, infection elimination, use of dressings and offloading was significantly more likely
to achieve complete wound closure compared with SOC alone, with a median number of one application of the product. Integra is currently pursuing pre-
market approval for implant-based breast reconstruction with our Surgimend product. In 2022, we acquired SIA, which is also pursuing a pre-market approval
for IBBR. By offering two distinct product solutions, we believe we have the opportunity to build a leading position in the market. We completed design
control  activities  in  2022  for  a  Q1  2023  launch  of  Cytal  and  MicroMatrix  in  Europe  and  a  pilot  launch  of  the  Cardion  Pericardial  Patch  to  gain  clinical
experience for finding a private label partner for that product.

Electromechanical  Technologies  and  Instrumentation.  Because  our  electromechanical  products  and  instruments  address  significant  needs  in  surgical
procedures and limit uncertainty for surgeons, we continue to invest in approvals for new indications and next generation improvements to our market-leading
products. We have several active programs focused on life cycle management and innovation for capital and disposable products in our portfolio. Our product
development efforts are focused on core clinical applications in cerebrospinal fluid ("CSF") management, neuro-critical care monitoring, minimally invasive
instruments and electrosurgery and ultrasonic medical technologies, as well as our ambition to transform the standard of care in neurosurgery with product
advancements in MIS and ICH. Our lighting franchise is among the most dynamic in the industry.

We  are  focused  on  the  development  of  core  clinical  applications  in  our  electromechanical  technologies  portfolio.  In  2022,  we  made  progress  to  several
enhancements  to  our  CUSA  Clarity  Tissue  Ablation  System.  The  extended  laparoscopic  tip  was  launched  in  the  U.S.  to  enhance  laparoscopic  liver
procedures. In addition, a single-sided bone tip received 510(k) approval. Commercial launch is expected in the first quarter of 2023. We continue to update
our  CUSA  Clarity  platform  by  incorporating  new  ultrasonic  handpiece  and  integrated  electrosurgical  capabilities.  We  continue  to  work  with  several
instrument partners to bring new surgical instrument platforms to the market.

We are focused on the development of core clinical applications in our electromechanical technologies portfolio. In June 2022, we launched the Neutus  EVD
system, our first external ventricular drain (“EVD") in China. The Neutus EVD system is manufactured in China by Shanghai Haoju Medical Technology Co.,
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Ltd. under an exclusive distribution arrangement. The device is used in the management of cerebrospinal fluid and is highly complementary to our Bactiseal
catheter and advanced intercranial pressure monitoring products.

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In the third quarter of 2021, we launched our CereLink ICP Monitor System in the U.S. and Europe and continued the global rollout in the first half of 2022.
On  August  18,  2022,  the  Company,  after  consultation  with  the  FDA  and  other  regulatory  authorities  outside  of  the  United  States,  initiated  an  immediate
voluntary  global  product  removal  of  all  CereLink   intracranial  pressure  monitors.  See  Item  1A.  Risk  Factors,  under  the  heading  Risks  Related  to  our
Regulatory Environment and under Item 7. General Management's Discussion and Analysis of Financial Condition and Results of Operations - FDA Matters
of this Annual Report on Form 10-K for further discussion.

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In 2022, we continued to advance the early-stage technology platforms we acquired in 2019. Through the acquisition of Arkis Biosciences, Inc. ("Arkis") we
added a platform technology, CerebroFlo  external ventricular drainage ("EVD"), catheter with Endexo  technology, a permanent additive designed to reduce
the  potential  for  catheter  obstruction  due  to  thrombus  formation.  The  CerebroFlo  EVD  Catheter  has  demonstrated  an  average  of  99%  less  thrombus
accumulation onto its surface, in vitro, compared to a market leading EVD catheter. Our work to combine our bactiseal antimicrobial technology with the
Endexo anti-occlusive technology obtained through our 2019 acquisition of Arkis continues to progress for both a silicone-based hydrocephalus and EVD
project.

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In 2019, we also acquired Rebound Therapeutics Corporation ("Rebound Therapeutics"), a company that specialized in single-use medical device, known as
Aurora Surgiscope, which is the only tubular retractor system designed for cranial surgery with an integrated access channel, camera and lighting. In the third
quarter of 2021, we conducted a limited clinical launch of the Aurora Surgiscope for use in minimally invasive neurosurgery as well as initiated a registry
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called MIRROR to collect data on early surgical intervention using this same technology platform for the treatment of ICH. In 2022, we launched the Aurora

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Evacuator with Coagulation device in the U.S., designed to be used in conjunction with our Aurora Surgiscope to safely address and evacuate blood in the
brain caused by hemorrhagic stroke. 

RESOURCES

In  general,  raw  materials  essential  to  our  businesses  are  readily  available  from  multiple  sources.  For  reasons  of  quality  assurance,  availability,  or  cost
effectiveness, certain components and raw materials are available only from a sole supplier. Our practice is to maintain sufficient inventory of components so
that our production will not be significantly disrupted even if a particular component or material is not available for a period of time.

Certain of our products, including but not limited to our dermal regeneration products, duraplasty products, wound care products, and nerve and tendon repair
products,  contain  material  derived  from  bovine  tissue.  We  take  great  care  to  provide  products  that  are  safe  and  free  of  agents  that  can  cause  disease.  In
particular, the collagen used in the products that we manufacture is derived from the deep flexor tendon of cattle less than 24 months old from New Zealand, a
country that has never had a reported case of bovine spongiform encephalopathy ("BSE") (otherwise known as mad cow disease), from the U.S. or from fetal
bovine dermis. The World Health Organization classifies different types of cattle tissue for relative risk of BSE transmission. Deep flexor tendon and fetal
bovine skin are in the lowest-risk category for BSE transmission, and therefore considered to have a negligible risk of containing the agent that causes BSE.

INTELLECTUAL PROPERTY

We  seek  patent  and  trademark  protection  for  our  key  technology,  products  and  product  improvements,  both  in  the  U.S.  and  in  selected  foreign  countries.
When determined appropriate, we have enforced and plan to continue to enforce and defend our patent and trademark rights. In general, however, we do not
rely solely on our patent and trademark estate to provide us with any significant competitive advantages as it relates to our existing product lines. We also rely
upon trade secrets and continuing technological innovations to develop and maintain our competitive position. In an effort to protect our trade secrets, we
have  a  policy  requiring  our  employees,  consultants  and  advisors  to  execute  proprietary  information  and  invention  assignment  agreements  upon
commencement of employment or consulting relationships with us. These agreements also provide that all confidential information developed or made known
to the individual during the course of their relationship with us must be kept confidential, except in specified circumstances.
AccuDrain ,  AmnioExcel ,  Aquasonic ,  Auragen ,  Aurora   Surgiscope ,  Bactiseal ,  BioDFence ,  BioDOptix ,  Brainet ,  Budde ,  Buzz™,  CereLink ,
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CerebroFlo   EVD  Catheter  with  Endexo   Technology,  Codman ,  Codman  Accu-Flo ,  Codman  Bicol ,  Codman   Certas
Plus,  Codman
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Hakim Programmable  valve,  Codman  Holter ,  Codman  ICP  Express ,  Codman  Microsensor ,  Codman  VersaTru ,  Codman  VPV ,  Contour-Flex ,
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Cranioplastic   CRW   CRW  Precision™,  Ctherm™,  CUSA ,  Cytal ,  DirectLink ,  DuraGen ,  DuraSeal ,  DuraSorb   Gentrix ,  HeliCote ,  HeliPlug ,
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HeliTape   HeliMend ,  Helistat ,  Helitene ,  Hermetic™,  Hy-Tape ,  Integra ,  IntegraLink Isocool ,  Jarit ,  Lead-Lok™,  Licox ,  LimiTorr™,  Luxtec
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Mayfield ,  MatriStem  UBM™,  MediHone ,  MicroFrance ,  MicroMatrix   Miltex ,  Mischler™,  MoniTorr  ICP™,  Natus ,  NeuraGen ,  NeuraWrap™,
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Nicolet , Omnigraft , Omni-Tract ,  OSV  II , Padgett , PriMatrix ,  Pureflow™,  Q-Snor™,  Redmond™,  Revize™,  Ruggles ,  Signacreme ,  SurgiMend ,
TCC-EZ ,  TenoGlide ,  TissueMend ,  Ultra  VS™,  VersaTru ,  Xtrasorb   zRIP™,  and  the  Integra  logo  are  some  of  the  material  trademarks  of  Integra
LifeSciences Corporation and its subsidiaries. MAYFIELD  is a registered trademark of SM USA, Inc., and is used by Integra under license.

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SEASONALITY

Revenues during our fourth quarter tend to be stronger than other quarters because many hospitals increase their purchases of our products during the fourth
quarter to coincide with the end of their budget cycles in the U.S. In general, our first quarter usually has lower revenues than the preceding fourth quarter, the
second and third quarters have higher revenues than the first quarter, and the fourth quarter revenues are the highest in the year. The main exceptions to this
pattern occur because of material acquisitions as well as impacts of the COVID-19 pandemic.

GOVERNMENT REGULATION AND COMPLIANCE

We  are  a  manufacturer  and  marketer  of  medical  devices  and  Human  Tissue  and  Cell  Based  Products  ("HCT/Ps")  and  therefore  are  subject  to  extensive
regulation by the FDA, the Center for Medicare Services of the U.S. Department of Health and Human Services, other federal governmental agencies and, in
some  jurisdictions,  by  state  and  foreign  governmental  authorities.  These  regulations  govern  the  introduction  of  new  medical  devices  and  HCT/Ps,  the
observance of certain standards with respect to the design, manufacture, testing, labeling, promotion and sales of the products, the maintenance of certain
records, the ability to track devices, the reporting of potential product defects, the import and export of products, and other matters.

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United States Food and Drug Administration

Our  products  are  subject  to  extensive  regulation  particularly  as  to  safety,  efficacy  and  adherence  to  FDA  Quality  System  Regulation,  and  related
manufacturing standards. Medical device products are subject to rigorous FDA and other governmental agency regulations in the United States and similar
regulations  of  foreign  agencies  abroad.  The  FDA  regulates  the  design,  development,  research,  preclinical  and  clinical  testing,  introduction,  manufacture,
advertising, labeling, packaging, marketing, distribution, import and export, and record keeping for such products, in order to ensure that medical products
distributed  in  the  United  States  are  safe  and  effective  for  their  intended  use.  In  addition,  the  FDA  is  authorized  to  establish  special  controls  to  provide
reasonable assurance of the safety and effectiveness of most devices. Non-compliance with applicable requirements can result in import detentions, fines, civil
and  administrative  penalties,  injunctions,  suspensions  or  losses  of  regulatory  approvals,  recall  or  seizure  of  products,  operating  restrictions,  refusal  of  the
government to approve product export applications or allow us to enter into supply contracts, and criminal prosecution. The regulatory process for obtaining
product approvals and clearances can be onerous and costly. The FDA requires, as a condition to marketing a medical device in the U.S., that we secure a
Premarket Notification clearance pursuant to Section 510(k) of the Federal Food, Drug and Cosmetic Act (the "FD&C Act"), or an approved PMA application
(or supplemental PMA application). Obtaining these approvals and clearances can take up to several years and may involve preclinical studies and clinical
trials. The FDA also may require a post-approval clinical study as a condition of approval. To perform clinical trials for significant risk devices in the U.S. on
an unapproved product, we are required to obtain an Investigational Device Exemption from the FDA. The FDA also may require a filing for approval prior to
marketing products that are modifications of existing products or new indications for existing products. Moreover, after clearance/approval is given, if the
product is shown to be hazardous or defective, the FDA and foreign regulatory agencies have the power to withdraw the clearance or approval, as the case
may be, or require us to change the device, its manufacturing process or its labeling, to supply additional proof of its safety and effectiveness or to recall,
repair, replace or refund the cost of the medical device. Because we currently export medical devices manufactured in the U.S. that have not been approved by
the FDA for distribution in the U.S., we are required to obtain approval/registration in the country to which we are exporting and maintain certain records
relating to exports and make these available to the FDA for inspection, if required.

Human Cells, Tissues and Cellular and Tissue-Based Products

Integra,  through  its  wholly-owned  subsidiary  BioD  LLC  ("BioD"),  is  involved  with  the  recovery,  processing,  storage,  transportation  and  distribution  of
donated  amniotic  tissue.  The  FDA  has  specific  regulations  governing  HCT/Ps.  An  HCT/P  is  a  product  containing,  or  consisting  of,  human  cells  or  tissue
intended for transplantation into a human patient. Examples of HCT/Ps include bone, ligament, skin and cornea.

Some  HCT/Ps  fall  within  the  definition  of  a  biological  product,  medical  device  or  drug  regulated  under  the  FD&C  Act.  These  biologic,  device  or  drug
HCT/Ps must comply both with the requirements exclusively applicable to HCT/Ps and, in addition, with requirements applicable to biologics, devices or
drugs, including premarket clearance or approval from the FDA.

Section 361 of the Public Health Service Act ("Section 361") authorizes the FDA to issue regulations to prevent the introduction, transmission or spread of
communicable disease. HCT/Ps regulated as “361” HCT/Ps are subject to requirements relating to registering facilities and listing products with the FDA,
screening and testing for tissue donor eligibility, and Good Tissue Practices when processing, storing, labeling, and distributing HCT/Ps, including required
labeling information, stringent record keeping, and adverse event reporting.

The American Association of Tissue Banks ("AATB") has issued operating standards for tissue banking. Compliance with these standards is a requirement in
order to become an AATB-accredited tissue establishment. In addition, some states have their own tissue banking regulations. We are licensed or have permits
for tissue banking in California, Delaware, Illinois, Maryland, New York, Oregon, and Tennessee. In Tennessee, we are registered with the FDA Center for
Biological Evaluations and Research.

Procurement of certain human organs and tissue for transplantation is subject to the restrictions of the National Organ Transplant Act, which prohibits the
transfer of certain human organs, including skin and related tissue for valuable consideration, but permits the reasonable payment associated with the removal,
transportation, implantation, processing, preservation, quality control and storage of human tissue and skin. BioD is a registered Tissue Bank and is involved
with the recovery, storage and transportation of donated human amniotic tissue.

On June 22, 2015, the FDA issued an Untitled Letter (the "Untitled Letter") alleging that BioD's morselized amniotic membrane tissue-based products do not
meet  the  criteria  for  regulation  as  HCT/Ps  solely  under  Section  361  and  that,  as  a  result,  BioD  would  need  a  biologics  license  to  lawfully  market  those
morselized  products.  Since  the  issuance  of  the  Untitled  Letter,  BioD  and  the  Company  has  made  known  to  the  FDA  their  disagreement  with  the  FDA’s
assertion that certain products are more than minimally manipulated. The FDA has not changed its position that certain of the BioD acquired products are not
eligible  for  marketing  solely  under  Section  361.  In  July  2020,  the  FDA  issued  the  final  guidance  document  related  to  human  tissue  titled,  “Regulatory
Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous Use” (the “2020 HCT/P Final
Guidance”). The 2020 HCT/P Final Guidance document supersedes the November 2017 guidance by the same title.

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The HCT/P Final Guidance maintains the FDA’s position that products such as the Company’s morselized amniotic membrane tissue-based products do not
meet the criteria for regulation solely as HCT/Ps. In addition, in the November 2017 guidance, the FDA articulated a risk-based approach to enforcement and,
while some uses for amniotic membrane tissue-based products would have as much as thirty-six months of enforcement discretion, other high risk uses could
be subject to immediate enforcement action. The 2020 HCT/P Final Guidance maintained this approach and extended the discretionary enforcement period to
May 31, 2021.

Considering the risk of enforcement action, the Company discontinued the manufacturing of all morselized amniotic membrane tissue-based products prior to
May 31, 2021. We no longer distribute these products. As of December 31, 2022, the Company has not received any further notice of enforcement action from
the FDA regarding its morselized amniotic membrane tissue-based products.

Medical Device Regulations

Unless  an  exemption  applies,  the  FDA  requires  that  a  manufacturer  introducing  a  new  medical  device  or  a  new  indication  for  use  of  an  existing  medical
device  obtain  either  a  Section  510(k)  premarket  notification  clearance  or  a  PMA,  before  introducing  it  into  the  U.S.  market.  The  type  of  marketing
authorization is generally linked to the classification of the device. The FDA classifies medical devices into one of three classes (Class I, II or III) based on
the degree of risk the FDA determines to be associated with a device and the level of regulatory control deemed necessary to ensure the device’s safety and
effectiveness.

The process of obtaining a Section 510(k) clearance generally requires the submission of performance data and often clinical data, which in some cases can be
extensive, to demonstrate that the device is “substantially equivalent” to a device that was on the market before 1976 or to a device that has been found by the
FDA  to  be  “substantially  equivalent”  to  such  a  pre-1976  device,  a  predecessor  device  is  referred  to  as  “predicate  device.”  As  a  result,  FDA  clearance
requirements may extend the development process for a considerable length of time. In addition, in some cases, the FDA may require additional review by an
advisory  panel,  which  can  further  lengthen  the  process.  The  PMA  process,  which  is  reserved  for  new  devices  that  are  not  substantially  equivalent  to  any
predicate  device  and  for  high-risk  devices  or  those  that  are  used  to  support  or  sustain  human  life,  may  take  several  years  and  requires  the  submission  of
extensive performance and clinical information.

Medical devices can be marketed only for the indications for which they are cleared or approved. After a device has received 510(k) clearance for a specific
intended use, any change or modification that significantly affects its safety or effectiveness, such as a significant change in the design, materials, method of
manufacture or intended use, may require a new 510(k) clearance or PMA approval and payment of an FDA user fee. The determination as to whether or not
a modification could significantly affect the device’s safety or effectiveness is initially left to the manufacturer using available FDA guidance; however, the
FDA may review this determination to evaluate the regulatory status of the modified product at any time and may require the manufacturer to cease marketing
and recall the modified device until 510(k) clearance or PMA approval is obtained. The manufacturer may also be subject to significant regulatory fines or
penalties.

We  also  are  required  to  register  with  the  FDA  as  a  medical  device  manufacturer  and  any  devices  we  manufacture  and  distribute  pursuant  to  clearance  or
approval  by  the  FDA  are  subject  to  pervasive  and  continuing  regulation  by  the  FDA  and  certain  state  agencies.  These  include  product  listing  and
establishment  registration  requirements,  which  help  facilitate  FDA  inspections  and  other  regulatory  actions,  and  our  manufacturing  sites  are  subject  to
periodic inspection by the FDA for compliance with the FDA's Quality System Regulations. These regulations require that we manufacture our products and
maintain our documents in a prescribed manner with respect to design, manufacturing, testing and control activities. Further, we are required to comply with
various FDA requirements and other legal requirements for labeling and promotion. If the FDA believes that a company is not in compliance with applicable
regulations, it may issue a warning letter, institute proceedings to detain or seize products, issue a recall order, impose operating restrictions, enjoin future
violations and assess civil penalties against that company, its officers or its employees and may recommend criminal prosecution to the U.S. Department of
Justice. All Integra manufacturing facilities participate in the Medical Device Single Audit Program and are audited annually for compliance with the Quality
System for US FDA, Canada, Australia, Brazil, and Japan.

Medical device regulations also are in effect in many of the countries in which we do business outside the U.S. In the European Economic Area ("EEA"),
which is comprised of the 27 member states of the European Union plus Norway, Iceland and Liechtenstein, medical devices need to comply with specific
requirements. These requirements were previously known as "Essential Requirements" under the former EU Medical Devices Directive (Council Directive
93/42/EEC,  or  MDD)  and  are  now  defined  "General  Safety  and  Performance  Requirements  (GSPR)"  under  the  new  EU  Medical  Devices  Regulation
(Regulation (EU) 2017/745, or "EU MDR"). Although the requirements set forth in the EU MDR are generally consistent with those laid out in the MDD
(with a few exceptions), the EU MDR is intended, among other things, to establish a uniform, transparent, predictable and sustainable regulatory framework
across the EEA for medical devices and ensure a high level of safety and health while supporting innovation. These laws range from comprehensive medical
device approval and Quality System requirements for some or all of our medical device products to simpler requests for product data or certifications. Under
the European Union Medical Device Directive, medical devices must meet the Medical Device Directive standards and receive

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CE Mark Certification prior to marketing in the EEA. Although we continue to transition our certification profile to meet the new EU MDR requirements,
these stricter regulations set forth in the EU MDR may pose additional challenges for Integra to continue marketing products in the EU as these regulations
come into force. See “Item 1A. Risk Factors - We are subject to stringent domestic and foreign  medical  device  regulations  and  oversight  and  any  adverse
action may adversely affect our ability to compete in the marketplace and our financial condition and business operations” of this Annual Report on Form 10-
K.

CE Mark Certification requires a comprehensive quality system program, technical documentation, clinical evaluation and data on the product which are then
reviewed, by a Notified Body. A Notified Body is an organization designated by the national governments of the EU member states to make independent
judgments about whether a product complies with the requirements established by each CE marking directive. The Medical Device Directive, Medical Device
Regulation,  ISO  9000  series  and  ISO  13485  are  recognized  international  quality  standards  that  are  designed  to  ensure  that  we  develop  and  manufacture
quality  medical  devices.  Other  countries  are  also  instituting  regulations  regarding  medical  devices  or  interpreting  and  enforcing  existing  regulations  more
strictly.  Compliance  with  these  regulations  requires  extensive  documentation  and  clinical  reports  for  our  products,  revisions  to  labeling,  and  other
requirements such as facility inspections to comply with the registration requirements. A recognized Notified Body audits our facilities annually to verify our
compliance with the ISO 13485 Quality System standard.

Certain countries, as well as the EU, have issued regulations that govern products that contain materials derived from animal sources. Regulatory authorities
are  particularly  concerned  with  materials  infected  with  the  agent  that  causes  BSE.  These  regulations  affect  our  dermal  regeneration  products,  duraplasty
products, hernia repair products, biomaterial products for the spine, nerve and tendon repair products and certain other products, all of which contain material
derived from bovine tissue. Although we take great care to provide that our products are safe and free of agents that can cause disease, products that contain
materials  derived  from  animals,  including  our  products,  may  become  subject  to  additional  regulation,  or  even  be  banned  in  certain  countries,  because  of
concern  over  the  potential  for  prion  transmission.  Significant  new  regulations,  a  ban  of  our  products,  or  a  movement  away  from  bovine-derived  products
because  of  an  outbreak  of  BSE  could  have  a  material,  adverse  effect  on  our  current  business  or  our  ability  to  expand  our  business.  See  “Item  1A.  Risk
Factors – Risks Related to our Regulatory Environment" of this Annual Report on Form 10-K.

Postmarket Requirements. After a device is cleared or approved for commercial distribution, numerous regulatory requirements apply. These include the FDA
Quality System Regulations which cover the procedures and documentation of the design, testing, production, control, quality assurance, labeling, packaging,
sterilization,  storage  and  shipping  of  medical  devices;  the  FDA's  general  prohibition  against  promoting  products  for  unapproved  or  'off-label'  uses;  the
Medical  Device  Reporting  regulation,  which  requires  that  manufacturers  report  to  the  FDA  if  their  device  may  have  caused  or  contributed  to  a  death  or
serious injury or malfunctioned in a way that would likely cause or contribute to a death or serious injury if it were to recur; and the Reports of Corrections
and Removals regulation, which require manufacturers to report recalls and field corrective actions to the FDA if initiated to reduce a risk to health posed by
the device or to remedy a violation of the FD&C Act. Postmarket requirements are also followed globally where our products are registered and approved.
These foreign jurisdictions have similar requirements to the FDA which include reporting requirements such as adverse events and recalls.

Other regulations

Anti-Bribery Laws. In the U.S., we are subject to laws and regulations pertaining to healthcare fraud and abuse, including anti-kickback laws and physician
self-referral laws that regulate the means by which companies in the health care industry may market their products to hospitals and health care professionals
and may compete by discounting the prices of their products. Similar anti-bribery laws exist in many of the countries in which we sell our products outside the
U.S., as well as the United States Foreign Corrupt Practices Act (which addresses the activities of U.S. companies in foreign markets). Our products also are
subject  to  regulation  regarding  reimbursement,  and  U.S.  healthcare  laws  apply  when  a  customer  submits  a  claim  for  a  product  that  is  reimbursed  under  a
federally funded healthcare program. These global laws require that we exercise care in designing our sales and marketing practices, including interactions
with  healthcare  professionals,  and  customer  discount  arrangements.  See  “Item  1A.  Risk  Factors  –  We  are  exposed  to  a  variety  of  risks  relating  to  our
international sales and operations” of this Annual Report on Form 10-K for further details.

Import-export. Our international operations subject us to laws regarding sanctioned countries, entities and persons, customs, and import-export. Among other
things, these laws restrict, and in some cases can prevent, U.S. companies from directly or indirectly selling goods, technology or services to people or entities
in certain countries. In addition, these laws require that we exercise care in our business dealings with entities in and from foreign countries.

Hazardous materials. Our research, development and manufacturing processes involve the controlled use of certain hazardous materials. We are subject to
country-specific, federal, state and local laws and regulations governing the use, manufacture, storage, handling and disposal of these materials and certain
waste  products.  We  believe  that  our  environmental,  health  and  safety  procedures  for  handling  and  disposing  of  these  materials  comply  with  the  standards
prescribed by the controlling laws and regulations. However, risk of accidental releases or injury from these materials is possible. These risks are managed to
minimize or eliminate associated business impacts. In the event of this type of accident, we could be held liable for damages

11

and face a liability that could exceed our resources. We could be subject to a regulatory shutdown of a facility that could prevent the distribution and sale of
products manufactured there for a significant period of time, and we could suffer a casualty loss that could require a shutdown of the facility in order to repair
it,  any  of  which  could  have  a  material,  adverse  effect  on  our  business.  Although  we  continuously  strive  to  maintain  full  compliance  with  respect  to  all
applicable global environmental, health and safety laws and regulations, we could incur substantial costs to fully comply with future laws and regulations, and
our operations, business or assets may be negatively affected. Furthermore, global environmental, health and safety compliance is an ongoing process. Integra
has compliance procedures in place for compliance with Employee Health & Safety laws, driven by a centrally led organizational structure that ensures proper
implementation, which is essential to our overall business objectives.

In addition to the above regulations, we are, and may be, subject to regulation under country-specific federal and state laws, including, but not limited to,
requirements regarding record keeping, and the maintenance of personal information, including personal health information. As a public Company, we are
subject to the securities laws and regulations, including the Sarbanes-Oxley Act of 2002. We also are subject to other present and could be subject to possible
future, local, state, federal and foreign regulations.

Third-Party Reimbursement. Healthcare providers that purchase medical devices generally rely on third-party payors, including, in the U.S., the Medicare and
Medicaid programs and private payors, such as indemnity insurers, employer group health insurance programs and managed care plans, to reimburse all or
part of the cost of the products. As a result, demand for our products is and will continue to be dependent in part on the coverage and reimbursement policies
of these payors. The manner in which reimbursement is sought and obtained varies based upon the type of payor involved and the setting in which the product
is  furnished  and  utilized.  Reimbursement  from  Medicare,  Medicaid  and  other  third-party  payors  may  be  subject  to  periodic  adjustments  as  a  result  of
legislative, regulatory and policy changes, as well as budgetary pressures. Possible reductions in, or eliminations of, coverage or reimbursement by third-party
payors, or denial of, or provision of uneconomical reimbursement for new products may affect our customers' revenue and ability to purchase our products.
Any changes in the healthcare regulatory, payment or enforcement landscape relative to our customers' healthcare services have the potential to significantly
affect our operations and revenue.

Data Privacy and Cybersecurity Laws and Regulations. As a business with a significant global footprint, compliance with evolving regulations and standards
in data privacy and cybersecurity (relating to the confidentiality and security of our information technology systems, products such as medical devices, and
other services provided by us) may result in increased costs, lower revenue, new complexities in compliance, new challenges for competition, and the threat
of increased regulatory enforcement activity. Our business relies on the secure electronic transmission, storage and hosting of sensitive information, including
personal information, financial information, intellectual property, and other sensitive information related to our customers and workforce.

For example, in the U.S., the collection, maintenance, protection, use, transmission, disclosure and disposal of certain personal information and the security of
medical devices are regulated at the U.S. federal and state, and industry levels. U.S. federal and state laws protect the confidentiality of certain patient health
information, including patient medical records, and restrict the use and disclosure of patient health information by health care providers. For example, in the
U.S.  we  are  obligated  to  comply  with  the  requirements  of  the  Health  Insurance  and  Portability  Act  of  1996,  as  amended  by  the  Health  Information
Technology for Economic and Clinical Health Act of 2009 (collectively, “HIPPA”). Under HIPAA, the Department of Health and Human Services has issued
regulations, including the HIPAA Privacy, Security and Breach Notification Rules, to protect the privacy and security of protected health information used or
disclosed  by  covered  entities  including  health  care  providers  and  their  business  associates,  as  well  as  covered  subcontractors.  HIPAA  also  regulates
standardization of data content, codes and formats used in health care transactions and standardization of identifiers for health plans and providers. Penalties
for  violations  of  HIPAA  regulations  include  significant  civil  and  criminal  penalties  for  each  violation.  In  addition,  the  FDA  has  issued  guidance  advising
manufacturers to take cybersecurity risks into account in product design for connected medical devices and systems, to assure that appropriate safeguards are
in  place  to  reduce  the  risk  of  unauthorized  access  or  modification  to  medical  devices  that  contain  software  and  reduce  the  risk  of  introducing  threats  into
hospital systems that are connected to such devices. The FDA also issued guidance on post market management of cyber security in medical devices.

Outside the U.S., we are impacted by the privacy and data security requirements at the international, national and regional level, and on an industry specific
basis. Legal requirements in these countries relating to the collection, storage, handling and transfer of personal data and, potentially, intellectual property
continue to evolve with increasingly strict enforcement regimes. In Europe, for example, we are subject to EU General Data Protection Regulation ("GDPR")
which  requires  member  states  to  impose  minimum  restrictions  on  the  collection,  use  and  transfer  of  personal  data  and  includes,  among  other  things,  a
requirement for prompt notice of data breaches to data subjects and supervisory authorities in certain circumstances and significant fines for non-compliance.
The GDPR also requires companies processing personal data of individuals residing in the EU to comply with EU privacy and data protection rules.

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Please refer to “Item 1A. Risk Factors – We are subject to requirements relating to information technology which could adversely affect our business” of this
Annual Report on Form 10-K for additional discussion of the risks accompanying compliance with data privacy and cybersecurity laws and regulations.

These  laws  and  regulations  impact  the  ways  in  which  we  use  and  manage  personal  data,  protected  health  information,  and  our  information  technology
systems. They also impact our ability to move, store, and access data across geographic boundaries. Compliance with these requirements may require changes
in business practices, complicate our operations, and add complexity and additional management and oversight needs. They also may complicate our clinical
research activities, as well as product offerings that involve transmission or use of clinical data.

HUMAN CAPITAL

Workforce Demographics

As of December 31, 2022, we had approximately 3,722 regular full and part time employees and 874 contingent, subcontracted, and outsourced partners.

70% of our employees are located in the United States, 21% in Europe, 2% in Latin America and Canada and 7% in Asia Pacific which includes Australia and
New Zealand.

Diversity and Inclusion

A diverse workforce and an inclusive culture and work environment is a business priority and a key to our long-term success. Our commitment to diversity
and  inclusion  starts  at  the  top  with  our  Board  of  Directors  and  CEO.  At  all  levels  of  the  Company,  we  focus  on  attracting,  retaining,  and  developing  our
diverse talent.

Leadership Commitment and Accountability

Executive leadership set diversity and inclusion goals for the Company on an annual basis. Advancing diversity and inclusion initiatives to build stronger
teams  has  been  a  company-wide  goal  and  the  direct  engagement  of  executive  leadership  in  advancing  diversity  and  inclusion  initiatives  helps  to  promote
awareness throughout the Company.

Leadership Councils, Employee Resource Groups and External Partnerships

We are accountable to our diversity commitment through our leadership councils, employee resource groups, and external partnerships.

•

The Women’s Leadership Council, established in 2017 and chaired by our President & Chief Executive Officer, Jan De Witte, is a results-oriented
advisory group comprised of ten of our senior women leaders across Integra. The

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specific charter of the Council is to work together to identify ways to continue to attract and retain female talent, advance the development of our
women into leadership roles, increase the cultural awareness of the value of inclusion and diversity in our Company, and create specific development
forums for our high performing women at Integra.

•

Employee  Resources  Groups  encourage  a  culture  of  awareness  and  inclusion,  assist  in  the  attraction  and  retention  of  diverse  talent,  and  help
colleagues develop leadership skills. Members of the Executive Leadership Team serve as sponsors for each of Integra’s employee resource groups.
Integra currently has six Employee Resources Groups:

◦ Women of Integra Networks (WIN) with 20+ chapters globally
◦ African American Affinity Group
◦ Veteran Employee Resource Group
◦
◦ Asian American and Pacific Islander Network
◦

Integra PRIDE (LGBTQ+ Employee Resource Group)

Indian American Network

• We reinforce our commitment to diversity by partnering with other organizations focused on driving inclusion in the workplace including the CEO
Action for Diversity & Inclusion, the largest CEO-driven business commitment to advance diversity and inclusion in the work place and Healthcare
Businesswomen’s Association, an association dedicated to further the advancement and impact of women in the business of healthcare.

Promoting an inclusive culture through learning opportunities

To  help  drive  our  culture  of  inclusion,  our  colleagues  participate  in  programs  focused  on  how  to  manage  bias,  value  differences,  and  develop  inclusive
leadership skills.

• Members  of  our  executive  leadership,  senior  management  team,  and  larger  scope  leaders  participated  in  a  ½  day  Microinequities  training.  The
content includes understanding unconscious bias and microinequities, how to identify microinequities in day-to-day decisions and actions as leaders,
and ways to mitigate microinequities on an individual and organizational level.
In  2020,  we  launched  two  foundational  programs  to  promote  diversity  and  inclusion:  Introduction  to  Managing  Unconscious  Bias,  a  course  that
creates  awareness  of  unconscious  biases  in  the  workplaces  and  tools  to  build-bias  breaking  skills  and  Practicing  Inclusion  which  examines  what
practicing inclusion in the workplace looks like. These trainings are now mandatory for all new Integra hires.

•

• We regularly provide educational content and resources to aid our colleagues as they build cultural competency and inclusive leadership skills

Gender Diversity

We believe that our company is stronger and will deliver strong operating results, when we build diverse teams and leverage broad perspectives to meet the
needs of our shareholders, customers, colleagues, and communities we serve.

The breakout of our colleagues by gender:

48% of Integra’s overall population is female, 52% male. We continue to strive to ensure our diversity in our leadership ranks is representative of our overall
population.  Through  mentorship,  sponsorship,  recruitment  efforts,  and  development  programs  we  look  to  continue  to  grow  our  population  of  females  in
leadership roles at Integra. Currently, 38% of our executive leaders and 43% of senior leaders (non-executive vice presidents) are female.

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In  partnership  with  Leadership  Edge,  a  company  founded  by  women  leaders  and  dedicated  to  growing  and  mentoring  women.  Integra sponsors the Excel
Women’s Leadership Program. The  program  is  designed  to  accelerate  the  development  and  advancement  of  high  potential,  mid-career  female  leaders  into
senior leadership roles. The program has assisted in further building our pipeline of women leaders with 60% of the program’s graduates being promoted into
roles with increased responsibility.

Compensation and Benefits

Our compensation philosophy is designed to reinforce and align with our mission, business strategy, and financial needs. We invest in the physical, emotional and
financial  well-being  of  our  employees  through  our  robust  compensation  and  benefit  programs.  We  provide  market-competitive  compensation  and  benefits
based on benchmarking surveys we conduct regularly for all position levels against relevant peer companies. Our annual and long-term incentive packages are
linked directly to business and individual performance, with a balance of short- and long-term financial and strategic objectives. We have an employee stock
purchase plan. Eligibility for non-salary benefits such as salary continuance, life insurance, health insurance, and similar benefits, follows local regulations
and practices.

Integra is a pay-for-performance company committed to fair pay. All compensation decisions are made without regard to personal characteristics such as, but
not limited to, gender, race, color, national or ethnic origin, age, disability, sexual orientation, gender identity or expression, genetic information, religion, or
veteran  status.  As  part  of  our  commitment  to  compensation  equity,  Integra  regularly  conducts  a  pay  equity  analysis,  reviewing  how  our  organization
compensates employees against external and internal data in conjunction with the role and scope of each position and making adjustments if necessary.

Talent Development and Retention

We have comprehensive and effective human capital development programs in place because we believe that the personal success of our employees is critical
to the overall success of our business. To build a diverse and talented organization, we have invested in honing our recruiting and hiring processes to attract
top talent and engage new hires from the very beginning of their experience at Integra.

We  offer  a  variety  of  opportunities  for  our  employees  to  learn  and  grow.  Continued  learning  and  development  is  a  critical  component  of  employee  job
satisfaction,  retention,  and  career  advancement—and  ultimately,  a  driver  of  business  success.  We  encourage  and  promote  experiential,  collaborative,  and
formal learning programs. Employees are also encouraged to discuss with their managers the skills, training, and experience needed to grow and develop. In
addition to several skills-based trainings

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available (technical, sales, leadership ability) to all employees, managers may recommend external job-specific development programs to employees. These
programs are paid for directly by Integra.

Employee Health and Safety:

Integra is committed to providing a safe environment for all employees and visitors. We rely on our environmental, health and safety management systems as
well  as  entrusting  our  managers  to  oversee  and  ensure  health  and  safety  at  their  respective  sites  and  foster  a  workplace  culture  to  achieve  that  end.  We
implement our approach globally by our systems and support at regional and country levels from colleagues that implement proper safety protocols, identify
and  correct  hazards,  and  remain  safety  conscious  at  all  times.  Managers  are  expected  to  enforce  health  and  safety  regulations,  including  compliance  with
applicable  federal,  state  and  local  laws.  Our  Environmental  Health  and  Safety  ("EH&S")  organizational  structure  incorporates  both  workplace  EH&S
coordinators  and  compliance  teams.  We  have  developed  an  Incident  Procedure  Policy  and  General  Safety  Rules  that  guide  our  colleagues  to  improve  our
workplace environment, improve safety, and reduce risk and costs.

Throughout the COVID-19 pandemic, we have placed a high priority on employee health, providing resources to support our workforce. At the outset of the
pandemic,  we  sought  to  protect  the  health  and  safety  of  our  employees  unable  to  work  remotely,  including  those  in  research  and  development,  quality,
manufacturing, distribution and sales roles. Such measures included the institution of robust hygiene practices, distribution of personal protective equipment,
and  the  adoption  of  increased  sanitation  and  social  distancing  protocols.  We  continue  to  actively  monitor  the  COVID-19  pandemic  and  its  variants  and
respond based on guidance from U.S. and global health organizations, relevant governmental guidance, and evolving practices.

Employee Engagement & Wellbeing

We  regularly  seek  employee  feedback  and  sentiment  about  our  workplace  through  global  engagement  surveys  conducted  on  a  bi-annual  basis.  After  each
survey is complete, we share detailed results with senior management and all employees within each department. Each function or division appoints survey
administrators who work with their respective teams to understand the feedback and establish action items. We believe this process enables us to monitor
employee engagement and create a continuously improving, satisfying work environment for our employees.

We  are  committed  to  improving  the  quality  of  life  of  our  employees  and  their  families.  Our  health  and  wellbeing  programs  differ  by  country  and  typical
benefits include comprehensive health insurance, disability coverage, workplace accommodations, parental leave and other leaves of absence based on health
or life events (e.g., bereavement), employee assistance programs, fitness reimbursement, and flu shots. We also provide on-demand health advocates to help
employees navigate the health insurance system, access to digital health solutions, a weight management program, smoking cessation assistance, a substance
use disorder helpline, a diabetes health program and other similar programs to drive healthy behaviors and awareness.

FINANCIAL INFORMATION ABOUT GEOGRAPHIC AREAS

Financial information about our geographical areas is set forth in our financial statements Note 16, Segment and Geographic Information, to the Notes to
Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K).

AVAILABLE INFORMATION

We  are  subject  to  the  informational  requirements  of  the  Securities  Exchange  Act  of  1934,  as  amended,  (the  “Exchange  Act").  In  accordance  with  the
Exchange  Act,  we  file  annual,  quarterly  and  special  reports,  proxy  statements  and  other  information  with  the  Securities  and  Exchange  Commission,  ("the
SEC"). Our financial information may be viewed, including the information contained in this report, and other reports we file with the SEC, on the Internet,
without charge as soon as reasonably practicable after we file them with the SEC, in the “SEC Filings” page of the Investor Relations section of our website at
www.integralife.com. A copy may also be obtained for any of these reports, without charge, from our Investor Relations department, 1100 Campus Road,
Princeton, NJ 08540. Alternatively, reports filed may be viewed or obtained through the SEC's website at www.sec.gov.

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

We  have  made  statements  in  this  report,  including  statements  under  “Business”  and  “Management's  Discussion  and  Analysis  of  Financial  Condition  and
Results  of  Operations”  that  constitute  forward-looking  statements  within  the  meaning  of  Section  27A  of  the  Securities  Act  of  1933,  as  amended,  ("the
Securities Act"), and Section 21E of the Exchange Act. These forward-looking statements are subject to a number of risks, uncertainties and assumptions
about us including, among other things:

•

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the on-going and possible future effects of the COVID-19 pandemic and associated economic disruptions, including supply chain constraints and
inflation, on our business, financial condition, results of operations and cash flows;
general economic and business conditions, both nationally and in our international markets, including the effect of the continuing worldwide
macroeconomic uncertainty;

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our expectations and estimates concerning future financial performance, financing plans and the impact of competition;
anticipated trends in our business;
anticipated demand for our products, particularly capital equipment;
our ability to produce and deliver products in sufficient quantities to meet sales demands;
our expectations concerning our ongoing restructuring, integration and manufacturing transfer and expansion activities;
existing and future regulations affecting our business, and enforcement of those regulations;
our failure to comply with the substantial regulation related to quality standards applicable to our manufacturing and quality processes could have an
adverse effect on our business, financial condition, or results of operations;
our ability to obtain additional debt and equity financing to fund capital expenditures, working capital requirements and acquisitions;
physicians' willingness to adopt our recently launched and planned products, third-party payors' willingness to provide or continue reimbursement for
any of our products and our ability to secure regulatory approval for products in development;
initiatives launched by our competitors;
our ability to protect our intellectual property, including trade secrets;
our ability to complete acquisitions, integrate operations post-acquisition and maintain relationships with customers of acquired entities;
our ability to remediate all matters identified in FDA observations and warning letters that we received or may receive; and
other risk factors described in Item 1A. "Risk Factors" in this Annual Report on Form 10-K.

Forward-looking  statements  can  be  identified  by  forward-looking  words  such  as  “believe,”  “may,”  “could,”  “might,”  “will,”  “estimate,”  “continue,”
“anticipate,” “intend,” “seek,” “plan,” “expect,” “should,” “would” and similar expressions in this report. We undertake no obligation to publicly update or
revise  any  forward-looking  statements,  whether  as  a  result  of  new  information,  future  events  or  otherwise.  In  light  of  these  risks  and  uncertainties,  the
forward-looking events and circumstances discussed in this report may not occur and actual results could differ materially from those anticipated or implied in
the forward-looking statements.

ITEM 1A. RISK FACTORS

GLOBAL CHALLENGES AND MACROECONOMIC CONDITIONS

The continuing worldwide macroeconomic and geopolitical uncertainty may adversely affect our business and prospects.

Global  economic  disruptions,  including  the  COVID-19  pandemic,  have  continued  to  impact  the  global  supply  chain,  primarily  through  constraints  on  raw
materials and electronic components. Additionally, we have observed a reduction in both inbound and outbound transportation capacity as a result of port
closures and delays associated with the pandemic, which is causing longer lead times in receiving raw materials, as well as increased freight costs. These
highly competitive and constrained supply chain conditions are increasing our cost of sales, which has and may continue to adversely impact our profitability.
Given the ongoing uncertainty regarding the duration and extent of the COVID-19 pandemic, we are uncertain as to the duration and extent of constraint on
our supply chain and are unable to predict the extent to which it will affect our global operations.

Continued concerns about the systemic impact of potential long-term and wide-spread recession and geopolitical issues, including the war in Ukraine, have
contributed to increased market volatility and diminished expectations for economic growth in the world. Our business and results of operations have been
and may continue to be adversely impacted by changes in macroeconomic conditions, including inflation, rising interest rates and the accessibility of capital
markets. Uncertainty about global economic conditions may also cause decreased demand for our products and services and increased competition, which
could result in lower sales volume and downward pressure on the prices for our products, longer sales cycles, and slower adoption of new technologies. A
weakening of macroeconomic conditions may also adversely affect our suppliers, which could result in interruptions in supply.

Market acceptance of our medical products in the U.S. and other countries is dependent upon the medical equipment purchasing and procurement practices of
our customers, patient need for our products and procedures and the reimbursement of patients' medical expenses by government healthcare programs and
third-party payors. The continuing uncertainty surrounding global economic conditions and financial markets may cause the purchasers of medical equipment
to  decrease  their  procurement  activities.  Economic  uncertainty,  an  increase  in  unemployment  rates,  as  well  as  increasing  health  insurance  premiums,  co-
payments and deductibles may adversely affect demand for our products and procedures. Furthermore, governments and other third-party payors around the
world facing tightening budgets could move to further reduce the reimbursement rates or the scope of coverage offered, which could adversely affect sales of
our products.

Public health crises, such as the COVID-19 pandemic, have had, and could in the future have, a negative effect on our business.

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Our  global  operations  and  interactions  with  healthcare  systems,  providers  and  patients  around  the  world  expose  us  to  risks  associated  with  public  health
crises, including epidemics and pandemics such as COVID-19. In particular, the COVID-19 pandemic continues to cause significant volatility and uncertainty
in  the  global  and  regional  economies,  leading  to  changes  in  consumer  and  business  behavior,  market  fluctuations,  materials  and  product  shortages  and
restrictions on business and individual activities, all of which are materially impacting supply and demand in broad sectors of the world markets. Additionally,
the COVID-19 pandemic, together with general macroeconomic conditions, have led to disruptions in the global supply chain, primarily through a lack of
availability  of  raw  materials  and  electronic  components.  We  have  experienced  challenges  associated  with  material  and  component  availability  for  certain
product lines, longer shipping and delivery times for raw materials and components, constrained logistics capacity related to the movement of our products,
availability  of  skilled  labor  and  increased  costs  of  raw  materials,  components,  labor,  and  freight  and  courier  services.  Regional  COVID-19  case  volumes
(including  those  related  to  subsequent  variants),  actions  taken  by  governmental  authorities,  private  businesses  and  individuals,  such  as  “shelter-in-place”
orders and restrictions on travel and access to our customers or temporary closures of our facilities or the facilities of our suppliers, disruption and/or higher
costs to the Company’s supply chain, staffing shortages in hospitals and labor constraints in our facilities, could further impact our gross margins and our
ability to ship our products and supply our customers.

The emergence of new variants, vaccinations and public health measures are driving the pace of economic recovery unevenly in various regions. The direct
and indirect disruptions caused by the pandemic and the responses of both governments and individuals could negatively impact the number of surgical and
medical intervention procedures performed and have a material adverse effect on our business, financial condition, results of operations, or cash flows. The
extent to which fear of exposure to or actual effects of COVID-19, new variants, disease outbreak, epidemic or a similar widespread health concern impacts
our  business  will  depend  on  future  developments,  which  are  highly  uncertain  and  cannot  be  predicted  with  confidence,  such  as  the  speed  and  extent  of
geographic  spread  of  the  disease,  the  duration  of  the  outbreak,  travel  restrictions,  the  efficacy  of  vaccination  and  treatment;  impact  on  the  U.S.  and
international  healthcare  systems,  the  U.S.  economy  and  worldwide  economy;  the  timing,  scope  and  effectiveness  of  U.S.  and  international  governmental
response; and the impact on the health, well-being and productivity of our employees.

RISKS RELATING TO OUR BUSINESS

Our operating results may fluctuate.

Our  operating  results,  including  components  of  operating  results  such  as  gross  margin  and  operating  expenses,  may  fluctuate  from  time  to  time,  and  such
fluctuations could affect our stock price. Our operating results have fluctuated in the past and can be expected to do so from time to time in the future. Some
of the factors that may cause these fluctuations include:

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economic  conditions  worldwide,  which  could  affect  the  ability  of  hospitals  and  other  customers  to  purchase  our  products  and  could  result  in  a
reduction in elective and non-reimbursed operative procedures;
the impact of acquisitions, our ability to integrate acquisitions, and our restructuring activities including portfolio rationalization, and divestitures;
risks related to COVID-19 and other epidemics or similar widespread health concerns;
expenditures for major initiatives, including acquired businesses and integrations thereof and restructuring;
the timing of significant customer orders, which tend to increase in the fourth quarter coinciding with the end of budget cycles;
increased competition for a wide range of customers across all our product lines in the markets our products are sold;

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• market acceptance of our existing products, as well as products in development;
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retention of current employees and recruiting of new employees in light of market competition for talent and relevant skills;
the timing of regulatory approvals as well as changes in country-specific regulatory requirements;
changes in the exchange rates between the U.S. dollar and foreign currencies of countries in which we do business;
changes in the variable interest rates of our debt instruments which could impact debt service requirements;
potential backorders, lost sales and expenses incurred in connection with product recalls or field corrective actions;
disruption of our operations and sales resulting from extreme weather conditions or natural disasters that damage our manufacturing, distribution, or
infrastructure of those facilities, or the suppliers and service providers for those facilities;
our ability to manufacture and ship our products efficiently or in sufficient quantities to meet sales demands;
changes in the cost or decreases in the supply of raw materials and services, including sterilization, energy, steel and honey;
the timing of our research and development expenditures;
reimbursement  for  our  products  by  third-party  payors  such  as  Medicare,  Medicaid,  private  and  public  health  insurers  and  foreign  governmental
health systems;
the ability to maintain existing distribution rights to and from certain third parties;
the ability to maintain business if or when we opt to convert such business from distributors to a direct sales model;
the ability of our commercial sales representatives to obtain sales targets in a reasonable time frame;

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the impact of changes to our sales organization, continued channel expansion, including increased specialization;
peer-reviewed publications discussing the clinical effectiveness of the products we sell;
inspections of our manufacturing facilities for compliance with Quality System Regulations (Good Manufacturing Practices), which could result in
Form  483  observations,  warning  letters,  injunctions  or  other  adverse  findings  from  the  FDA  or  from  equivalent  regulatory  bodies,  and  corrective
actions, procedural changes and other actions that we determine are necessary or appropriate to address the results of those inspections, any of which
may affect production and our ability to supply our customers with our products;
changes in regulations or guidelines that impact the sales and marketing practices for products that we sell;
the increased regulatory scrutiny of certain of our products, including products which we manufacture for others, could result in removal from the
market or involve field corrective actions that could affect the marketability of our products;
enforcement or defense of intellectual property rights;
changes in tax laws, or their interpretations; and
the impact of goodwill and intangible asset impairment charges if future operating results of the acquired businesses are significantly less than the
results anticipated at the time of the acquisitions.

The industry and market segments in which we operate are highly competitive, and we may be unable to compete effectively with other companies.

There is intense competition among medical device companies. We compete with established medical technology companies in many of our product areas.
Competition also comes from early-stage companies, universities, research institutions and other non-profit entities. In certain cases, our products compete
primarily against medical practices that treat a condition without using a device or any particular product, such as the medical practices that use autograft
tissue  instead  of  our  dermal  regeneration  products,  duraplasty  products  and  nerve  repair  products,  or  that  use  other  technologies  that  cost  less  than  our
products.  Many  of  our  competitors  have  access  to  greater  financial,  technical,  research  and  development,  marketing,  manufacturing,  sales,  distribution,
administrative,  consulting  and  other  resources  than  we  do.  Our  competitors  may  be  more  effective  at  developing  commercial  products  or  navigating  the
regulatory approval process in the markets in which we operate. They may be able to gain market share by offering lower-cost products or products that enjoy
better reimbursement from third-party payors and foreign governmental health systems.

Our competitive position depends on our ability to achieve market acceptance for our products, develop new products, implement marketing plans, secure
regulatory  approval  for  products  under  development,  demonstrate  clinical  and  economic  effectiveness,  obtain  and  maintain  reimbursement  coverage  and
funding under third-party payors and foreign governmental health systems, obtain patent protection and produce products consistently in sufficient quantities
to meet demand. We may need to develop new applications for our products to remain competitive. Technological advances by one or more of our current or
future competitors or their achievement of superior reimbursement from third-party payors and foreign governmental health systems could render our present
or future products obsolete or uneconomical. Our future success will depend upon our ability to compete effectively against current technology as well as to
respond effectively to technological advances, changes in customers' requirements or in payor or regulatory evidence requirements. Additionally, purchasing
decisions of our customers may be based on clinical evidence or comparative effectiveness studies and, because of our vast array of products, we might not be
able to fund the studies necessary to gain entry or maintain our position or provide the required information to compete effectively. Other companies may
have more resources available to fund such studies. For example, competitors have launched and are developing products to compete with our dural repair
products, regenerative skin, neuro critical care monitors and ultrasonic tissue ablation devices, among others. In the current environment of managed care,
consolidation among health care providers, increased competition, and declining reimbursement rates, we have been increasingly required to compete on the
basis  of  price.  Competitive  pressures  could  adversely  affect  our  profitability.  Given  these  factors,  we  cannot  guarantee  that  we  will  be  able  to  compete
effectively or continue our level of success in the areas in which we compete.

Changes in the healthcare industry may require us to decrease the selling price for our products, may reduce the size of the market for our products, or
may eliminate a market, any of which could have a negative impact on our financial performance.

Trends toward managed care, healthcare cost containment and other changes in government and private sector initiatives in the U.S. and other countries in
which we do business are placing increased emphasis on the delivery of more cost-effective medical therapies that could adversely affect the sale and/or the
prices of our products. For example:

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third-party payors of hospital services and hospital outpatient services, including Medicare, Medicaid, private and public health insurers and foreign
governmental  health  systems,  annually  revise  their  payment  methodologies,  which  can  result  in  stricter  standards  for  reimbursement  of  hospital
charges for certain medical procedures or the elimination of reimbursement;
several  foreign  countries  have  implemented  reforms  of  their  respective  healthcare  sectors  in  an  effort  to  reduce  healthcare  spending,  including
restricting funding to only those medical technologies and procedures with proven effectiveness, increasing patient co-payments and providing for
payback measures. Governmental health systems have revised and continue to consider revisions of healthcare budgets, which could result in stricter
standards for implementing certain medical procedures, increased scrutiny of medical devices, and downward pricing pressure;

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• Medicare, Medicaid, private and public health insurer and foreign governmental cutbacks could create downward pricing pressure on our products;
•

in  the  U.S.,  Medicare  and  Medicaid  coverage  as  well  as  commercial  payor  coverage  determinations  could  reduce  or  eliminate  reimbursement  or
coverage for certain of our wound matrix, amniotic, surgical reconstruction and advanced wound dressing products as well as other products in most
regions, negatively affecting our market for these products, and future determinations could reduce or eliminate reimbursement or coverage for these
products in other regions and could reduce or eliminate reimbursement or coverage for other products;
there has been a consolidation among healthcare facilities and purchasers of medical devices in the U.S., some of whom prefer to limit the number of
suppliers from whom they purchase medical products, and these entities may decide to stop purchasing our products or demand discounts on our
prices;
in the U.S., we are party to contracts with group purchasing organizations, which negotiate pricing for many member hospitals, require us to discount
our prices for certain of our products and limit our ability to raise prices for certain of our products, particularly surgical instruments;
there is economic pressure to contain healthcare costs in domestic and international markets, and, regardless of the consolidation discussed above,
providers generally are exploring ways to cut costs by eliminating purchases or driving reductions in the prices that they pay for medical devices, or
increasing clinical or economic evidence thresholds for product formularies;
there  are  proposed  and  existing  laws,  regulations  and  industry  policies  in  domestic  and  international  markets  regulating  the  sales  and  marketing
practices and the pricing and profitability of companies in the healthcare industry;
proposed  laws  or  regulations  may  permit  hospitals  to  provide  financial  incentives  to  doctors  for  reducing  hospital  costs,  will  award  physician
efficiency, and will encourage partnerships with healthcare service and goods providers to reduce prices; and
there have been initiatives by third-party payors and foreign governmental health systems to challenge the prices charged for medical products that
could affect our ability to sell products on a competitive basis.

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Any and all of the above factors could materially and adversely affect our levels of revenue and our profitability.

Our current strategy involves growth through acquisitions, which requires us to incur substantial costs and potential liabilities for which we may never
realize  the  anticipated  benefits,  and  also  requires  us  to  successfully  integrate  acquired  businesses  into  our  business  operations  in  order  to  avoid  our
business being materially and adversely affected.

In addition to internally generated growth, our current strategy involves growth through acquisitions. Between January 1, 2020 and December 31, 2022, we
have acquired two businesses at a total cost of approximately $358.4 million which amount includes our acquisition of ACell, Inc. in January 2021 for $306.9
million  and  our  acquisition  of  Surgical  Innovation  Associates,  Inc.  for  $51.5  million  in  December  2022.  Both  of  these  acquisitions  added  products  to  our
complex wound management and plastic and reconstructive surgery product portfolios, respectively, and provides additional growth opportunities for our TT
segment.

We may be unable to continue to implement our growth strategy and it may ultimately be unsuccessful. A significant portion of our growth in revenues has
resulted from, and is expected to continue to result from, the acquisition of businesses or products complementary to our own. We engage in evaluations of
potential acquisitions and are in various stages of discussion regarding possible acquisitions, certain of which, if consummated, could be significant to us. Any
new acquisition could result in material transaction expenses, increased operating, amortization and interest expenses, and possible in-process research and
development  charges  for  acquisitions  that  do  not  meet  the  definition  of  a  “business,”  any  of  which  could  have  a  material,  adverse  effect  on  our  operating
results. Certain businesses that we acquire may not have adequate financial, disclosure, regulatory, quality or other compliance controls at the time we acquire
them and could require significant expenditures to address those controls or subject us to increased risk. As we grow by acquisition, we must manage and
integrate the new businesses to bring them into our systems for financial, disclosure, compliance, regulatory and quality control, realize economies of scale,
and control costs. Failure to integrate acquired businesses and operations (including acquired employees and systems), retain key customers and suppliers of
any acquired business or manage the cost of providing our products or price our products appropriately could preclude realization of the full benefits that we
expect  from  there  transactions.  Our  failure  to  meet  the  challenges  involved  in  integrating  the  business  in  order  to  realize  the  anticipated  benefits  of  the
acquisitions  could  cause  an  interruption  of,  or  loss  of  momentum  in,  our  activities  and  could  materially  and  adversely  affect  our  results  of  operations.  In
addition,  acquisitions  involve  other  risks,  including  diversion  of  management  resources  otherwise  available  for  the  running  of  our  business  and  the
development of our business as well as risks associated with entering markets in which our marketing teams and sales force has limited experience or where
experienced distribution alliances are not available. Some acquisitions may include the need for ongoing product development to occur consistent with time
sensitive milestones in order for the Company to achieve its commercial projections for the acquisition. Our future profitability will depend in part upon our
ability to develop our resources to adapt to these new products or business areas and to identify and enter into or maintain satisfactory distribution networks.
As  a  result  of  our  acquisitions  of  other  healthcare  businesses,  we  may  be  subject  to  the  risk  of  unanticipated  business  uncertainties,  regulatory  and  other
compliance matters or legal liabilities relating to those acquired businesses for which the sellers of the acquired businesses may not indemnify us, for which
we may not be able to obtain insurance (or adequate insurance), or for which the indemnification may not be sufficient to cover the ultimate liabilities. We

20

may not be able to identify suitable acquisition candidates in the future, obtain acceptable financing or consummate any future acquisitions. Certain potential
acquisitions are subject to antitrust and competition laws, which laws could impact our ability to pursue strategic acquisitions and could result in mandated
divestitures.  If  we  are  unsuccessful  in  our  acquisition  strategy,  we  may  be  unable  to  meet  our  financial  targets  and  our  financial  performance  could  be
materially and adversely affected.

These risks may be heightened in cases where the majority of the former businesses’ operations, employees and customers are located outside the U.S. Any
one or all of these factors could increase operating costs or lower anticipated financial performance. Many of these factors are also outside of our control. In
addition, dispositions of certain key products, technologies and other rights, including pursuant to conditions imposed on us to obtain regulatory approvals,
may affect our business operations.

Even  if  the  operations  of  the  businesses  are  integrated  successfully,  we  may  not  realize  the  full  benefits  of  the  acquisition,  including  the  synergies,  cost
savings  or  sales  or  growth  opportunities  that  we  expect.  These  benefits  may  not  be  achieved  within  the  anticipated  time  frame,  or  at  all.  Additional
unanticipated costs could be incurred in the integration of the businesses. All of these factors could cause a reduction to our earnings per share, decrease or
delay the expected accretive effect of the transaction, and negatively impact the price of our common stock.

Our future financial results could be adversely affected by impairments or other charges.

We are required to test both goodwill and indefinite-lived intangible assets for impairment on an annual basis based upon a fair value approach, rather than
amortizing them over time. We are also required to test goodwill and indefinite-lived intangible assets for impairment between annual tests if an event occurs
such as a significant decline in revenues or cash flows for certain products, or the discount rates used in the calculations of discounted cash flows change
significantly, or circumstances change that would more likely than not reduce our enterprise fair value below its book value. If such a decline, rate change or
circumstance  were  to  materialize,  we  may  record  an  impairment  of  these  intangible  assets  that  could  be  material  to  the  financial  statements.  See
“Management’s Discussion and Analysis of Financial Condition and Results of Operations - Critical Accounting Estimates” of this report.

The guidance on long-lived assets requires that we assess the impairment of our long-lived assets, including finite-lived intangible assets, whenever events or
changes in circumstances indicate that the carrying value may not be recoverable as measured by the sum of the expected future undiscounted cash flows.

Also, Company decisions and other economic factors relating to our trade names may occur over time. For instance, we may discontinue certain products in
the future as we continue to assess the profitability of our product lines. As a result, we may need to record impairment charges or accelerate amortization on
certain trade names or technology-related intangible assets in the future.

The value of a medical device business is often volatile, and the assumptions underlying our estimates made in connection with our assessments under the
guidance  may  change  as  a  result  of  that  volatility  or  other  factors  outside  our  control  and  may  result  in  impairment  charges.  The  amount  of  any  such
impairment charges could be significant and have a material, adverse effect on our reported financial results for the period in which the charge is taken and
could have an adverse effect on the market price of our securities, including the notes and the common stock into which they may be converted.

Lack  of  market  acceptance  for  our  products  or  market  preference  for  technologies  that  compete  with  our  products  could  reduce  our  revenues  and
profitability.

Market  acceptance  of  our  products  depends  on  many  factors,  including  our  ability  to  convince  prospective  customers  that  our  technology  is  an  attractive
alternative to other technologies, to manufacture products in sufficient quantities and at acceptable costs, and to supply and service sufficient quantities of our
products directly or through our distribution alliances. For example, the use of autograft tissue is a well-established means for repairing the dermis, and it
competes  for  acceptance  in  the  market  with  our  collagen-based  wound  care  products.  In  addition,  unfavorable  payment  amounts  or  adverse  coverage
determinations of third-party payors, including Medicare, Medicaid, private and public health insurers, and foreign governmental health systems, regarding
our products or third-party determinations that favor a competitor’s product over ours, could harm acceptance or continued use of our products. For example,
greater market acceptance of our wound graft products may ultimately depend on our ability to demonstrate that coverage and reimbursement are available
and favorable, or because they are an attractive, cost-effective alternative to other treatment options.

If there are negative events in the healthcare industry, whether real or perceived, there could be a negative impact on the industry as a whole. The industry is
subject to rapid and continuous change arising from, among other things, consolidation, technological improvements, the pressure on governments, third-party
payors  and  providers  to  reduce  healthcare  costs,  and  healthcare  reform  legislation  and  initiatives  domestically  and  internationally.  In  addition,  our  future
success depends, in part, on our ability to license and develop additional products. Even if we determine that a product candidate has medical benefits, the
cost of commercializing, either through internal development or payments associated with licensing arrangements, could be too high to justify development
and  we  could  ultimately  face  competitors  with  more  effective  products  and  better  reimbursement  status  that  cost  less  and  are  ready  for  commercial
introduction before our products. If we are unable to develop additional commercially viable products, our future prospects could be materially and adversely
affected.

21

One or more of these factors could vary unpredictably, and such variations could have a material, adverse effect on our competitive position. We may not be
able to adjust our contemplated plan of development to meet changing market demands.

It could be difficult to replace some of our suppliers.

Outside vendors, some of whom are sole-source suppliers, provide key components and raw materials used in the manufacture of our products. Although we
believe  that  alternative  sources  for  many  of  these  components  and  raw  materials  are  available,  any  interruption  in  supply  of  a  limited  or  sole-source
component  or  raw  material  could  harm  our  ability  to  manufacture  our  products  until  a  new  or  alternative  source  of  supply  is  identified  and  qualified.  In
addition, an uncorrected defect or supplier’s variation in a component or raw material, either unknown to us or incompatible with our manufacturing process,
could harm our ability to manufacture products. We may not be able to find a sufficient alternative supplier in a reasonable time period, or on commercially
reasonable terms, if at all, and our ability to produce and supply our products could be impaired. We believe that these factors are most likely to affect the
following products that we sell:

•

•
•

•
•
•
•
•

®

our  collagen-based  products  and  bovine-based  products,  such  as  the  Integra  Dermal  Regeneration  Template  and  wound  matrix  products,  the
DuraGen  family of products, our Absorbable Collagen Sponges, PriMatrix  and SurgiMend products;
our products made from silicone, such as our neurosurgical shunts and drainage systems and hemodynamic shunts;
products which use many different specialty parts, electrical components, or chemicals from numerous suppliers, such as our intracranial monitors,
shunts, catheters, tissue ablation, and headlights;
our biosynthetic products, including the DuraSeal sealant system and DuraSorb biosynthetic mesh scaffold;
products which are amniotic tissue-based
products which are porcine tissue-based;
products that use medical grade leptospermum honey, such as our Medihoney products; and
our TCC-EZ  total contact cast system products.

®

®

The  availability  of  amniotic  tissue-based  products  depends  upon,  among  other  factors,  the  availability  of  tissue  from  human  donors.  Access  to  donated
amniotic tissue could also be adversely impacted by regulatory changes or evolving public perceptions of the donor process.

Additionally,  many  of  our  products  require  sterilization  by  third-party  suppliers.  To  the  extent  these  suppliers  are  unable  to  provide  sterilization  services,
whether due to lack of capacity, regulatory requirements, environmental concerns such as those relating to ethylene oxide or otherwise, we may be unable to
transition sterilization to other suppliers in a timely or cost effective manner, or at all, which could have an adverse impact on our operating results.

Our supply chain and our cost of goods also may be negatively impacted by unanticipated price increases due to factors such as global economic disruptions,
electronic  component  shortages,  fear  of  future  or  ongoing  pandemics,  inflation,  including  wage  inflation,  recessionary  conditions  and  geopolitical  events,
including the war in Ukraine, all of which are beyond our control or the control of our suppliers.

While it is our policy to maintain sufficient inventory of components so that our production will not be significantly disrupted even if a particular component
or material is not available for a period of time, we remain at risk that we will not be able to qualify new components or materials quickly enough to prevent a
disruption if one or more of our suppliers ceases production of important components or materials.

We may experience difficulties, delays, performance impact or unexpected costs from consolidation of facilities and transfer of manufacturing facilities.

In recent years, we consolidated several facilities or transferred manufacturing operations from third parties to our existing internal manufacturing facilities
and may further undertake similar consolidations or transfers in the future in order to improve our cost structure, achieve increased operating efficiencies, and
improve our competitive standing or results of operations and/or to address unfavorable economic conditions. As part of these initiatives, we may also lose
favorable  tax  incentives  or  not  be  able  to  renew  leases  on  acceptable  terms.  We  may  further  reduce  staff,  make  changes  to  certain  capital  projects,  close
certain production operations and abandon leases for certain facilities that will not be used in our operations. In conjunction with any actions, we will continue
to make significant investments and build the framework for our future growth. We may not realize, in full or in part, the anticipated benefits and savings
from these efforts because of unforeseen difficulties, delays, implementation issues or unexpected costs. If we are unable to achieve or maintain all of the
resulting savings or benefits to our business or other unforeseen events occur, our business and results of operations may be adversely affected.

We may have significant product liability exposure and our insurance may not cover all potential claims.

We are exposed to product liability and other claims if our technologies or products are alleged to have caused harm. We may not be able to obtain insurance
for the potential liability on acceptable terms with adequate coverage or at reasonable costs. Any potential product liability claims could exceed the amount of
our insurance coverage or may be excluded from coverage under the terms of the policy. Our insurance may not be renewed at a cost and level of coverage
comparable to that then in effect.

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Economic and political instability around the world could adversely affect the ability of hospitals, other customers, suppliers and distributors to access
funds or otherwise have available liquidity, which could reduce orders for our products or interrupt our production or distribution or result in a reduction
in elective and non-reimbursed operative procedures.

Economic and political instability around the world could adversely affect the ability of hospitals and other customers to access funds to enable them to fund
their operating and capital budgets. As a result, hospitals and other customers could reduce budgets or put all or part of their budgets on hold or close their
operations,  which  could  have  a  negative  effect  on  our  sales,  particularly  the  sales  of  capital  equipment  such  as  our  ultrasonic  surgical  aspirators,
neuromonitors  and  cranial  stabilization  products,  or  result  in  a  reduction  in  elective  and  non-reimbursed  procedures.  The  occurrence  of  those  economic
conditions  could  make  it  more  difficult  for  us  to  accurately  forecast  and  plan  our  future  business  activities  and  depending  on  their  severity,  could  have  a
material, adverse effect on our business, financial condition and results of operations.

Our private-label product lines depend significantly on key relationships with third parties, which we could be unable to establish and maintain.

Our private-label business depends in part on entering into and maintaining long-term supply agreements with third parties. The third parties with whom we
have entered into agreements might terminate these agreements for a variety of reasons, including developing other sources for the products that we supply.
Termination of our most important relationships could adversely affect our expectations for the growth of private-label products.

RISKS RELATED TO OUR REGULATORY ENVIRONMENT

The adoption of healthcare reform in the U.S. and initiatives sponsored by other governments may adversely affect our business, results of operations
and/or financial condition.

Our operations may be substantially affected by potential fundamental changes in the global political, economic and regulatory landscape of the healthcare
industry. Government and private sector initiatives to limit the growth of healthcare costs are continuing in the U.S., and in many other countries in which we
do business, causing the marketplace to put increased emphasis on the delivery of more cost-effective treatments. These initiatives include price regulation,
competitive  pricing,  coverage  and  payment  policies,  comparative  effectiveness  of  therapies,  technology  assessments  and  managed-care  arrangements.  The
adoption of some or all of these initiatives could have a material, adverse effect on our financial condition and results of operations.

In the United States, the Patient Protection and Affordable Care Act (the “ACA”), signed into law in March 2010, includes several provisions that impact our
businesses in the U.S. The ACA includes provisions that, among other things, reduce and/or limit Medicare reimbursement, require all individuals to have
health insurance (with limited exceptions), and require detailed disclosure of transfers of value made to healthcare professionals. Other legislative changes
have been proposed and adopted since the Affordable Care Act was enacted, including The Budget Control Act of 2011, The American Taxpayer Relief Act
of 2012 and Medicare Access and CHIP Reauthorization Act of 2015, which, among other things, have reduced payments under Medicare and Medicaid to
certain healthcare providers or altered the formula by which Medicare makes annual payment adjustments. Congress also drafts and introduces, from time to
time, legislation that could significantly change the statutory provisions governing the regulation of medical devices. In addition, the FDA may change its
clearance  and  approval  policies,  adopt  additional  regulations  or  revise  existing  regulations,  or  take  other  actions,  which  may  prevent  or  delay  approval  or
clearance of our future products under development or impact our ability to modify our currently cleared products on a timely basis. For example, over the
last several years, the FDA has proposed reforms to its 510(k) clearance process, and such proposals could include increased requirements for clinical data
and a longer review period, or could make it more difficult for manufacturers to utilize the 510(k) clearance process for their products.

We cannot predict what impact ongoing uncertainty regarding federal and state health reform proposals, including the implementation or repeal of the ACA,
judicial review and interpretation of the ACA and other healthcare laws, instability of the insurance markets, changes in the U.S. administration and policy, an
expansion in government’s role in and/or additional proposals and/or changes to the U.S. health care system or its legislation will have on our customer’s
purchasing decisions and/or reimbursement which could have a material adverse effect on our business. We expect that additional state and federal health care
reform measures will be adopted in the future, including those initiatives affecting coverage and reimbursement for our products, any of which could limit the
amounts  that  federal  and  state  governments  will  pay  for  health  care  products  and  services,  which  could  adversely  affect  the  growth  of  the  market  for  our
products  or  demand  for  our  products,  or  result  in  additional  pricing  pressures.  We  cannot  predict  the  ultimate  content,  timing  or  effect  of  any  healthcare
reform legislation or the impact of potential legislation on us. We continue to monitor the implementation of such legislation and, to the extent new market or
industry trends or new governmental programs evolve, we will consider implementing or implement programs in response.

We  are  subject  to  stringent  domestic  and  foreign  medical  device  regulations  and  oversight  and  any  adverse  action  may  adversely  affect  our  ability  to
compete in the marketplace and our financial condition and business operations.

Our  products,  development  activities  and  manufacturing  processes  are  subject  to  extensive  and  rigorous  regulation  by  numerous  government  agencies,
including the FDA and comparable foreign agencies, as discussed in “Part 1, Item 1. Business –

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Government  Regulation.”  To  varying  degrees,  each  of  these  agencies  monitors  and  enforces  our  compliance  with  laws  and  regulations  governing  the
development, testing, manufacturing, labeling, marketing and distribution of our medical devices. We are also subject to regulations that may apply to certain
of  our  products  that  are  Drug/Device  Combination  products  or  are  considered  to  be  subject  to  pharmaceutical  regulations  outside  the  U.S.  The  process  of
obtaining marketing approval or clearance from the FDA and comparable foreign regulatory agencies for new products, or for enhancements or modifications
to  existing  products  could  be  costly,  time  consuming  and  burdensome,  lead  to  failed  clinical  trials  or  weakened  clinical  evidence,  involve  modifications,
repairs or replacements of our products and result in limitations on the indicated use of our products, which may negatively impact our ability to market our
products and services, result in delays or prevent full commercial realization of future products or service. Furthermore, failure to obtain timely approvals or
renewals  may  result  in  significant  penalties  and  fines.  Additional  regulations  govern  the  approval,  initiation,  conduct,  monitoring,  documentation  and
reporting of clinical studies to regulatory agencies in the countries or regions in which they are conducted. Failure to comply, could subject us to significant
enforcement actions and sanctions, including halting the study, rejection of data generated in the study, seizure of investigational devices or data, sanctions
against investigators, civil or criminal penalties, and other actions. In addition, without the data from one or more clinical studies, it may not be possible for us
to  secure  the  data  necessary  to  support  certain  regulatory  submissions,  to  secure  reimbursement  or  demonstrate  other  requirements.  We  cannot  assure  that
access to clinical investigators, sites and subjects, documentation and data will be available on the terms and timeframes necessary.

We  are  subject  to  extensive  complex  regulatory  requirements  by  domestic  and  foreign  government  agencies  and  any  failure  to  comply  with  our  ongoing
responsibilities  under  their  applicable  laws  and  regulations  could  result  in  a  material  adverse  impact  on  our  business.  Failure  to  comply  with  applicable
regulations  could  result  in  future  product  recalls,  injunctions  preventing  the  shipment  of  products  or  other  enforcement  actions  that  could  have  a  material
adverse effect on our business.

We also are subject to the European Medical Device Regulation, which was adopted by the European Union (“EU”) as a common legal framework for all EU
member states. The implementation for Class I products occurred on May 26, 2021 and the EUDAMED Database was implemented on May 26, 2022. Under
this  regulation,  companies  that  wish  to  manufacture  and  distribute  medical  devices  in  EU  member  states  must  meet  certain  quality  system,  and  safety
requirements as well as ongoing product monitoring responsibilities. Companies must also obtain a “CE” marking (i.e., a mandatory conformity marking for
certain products sold within the European Economic Area) for their products. Complying with the requirements of these regulations may require us to incur
significant expenditures. Expenditures for European Union Medical Device Regulation compliance activities amounted to $45.1 million for the year ended
December 31, 2022 and we anticipate incurring additional expenditures in connection with our on-going efforts to obtain certification for our products under
the European Medical Device Regulation. Various penalties exist for non-compliance with the laws implementing the European Medical Device Regulations
which if incurred, could have a material adverse impact on our business, results of operations and cash flows.

Further,  the  regulatory  environment  in  China  continues  to  evolve,  and  officials  in  the  Chinese  government  exercise  broad  discretion  in  deciding  how  to
interpret and apply regulations. It is possible that the Chinese government's current or future interpretation and application of existing or new regulations will
negatively impact our China operations, result in regulatory investigations or lead to fines or penalties.

In  addition,  we  are  subject  to  laws  and  regulations  that  govern  the  means  by  which  companies  in  the  healthcare  industry  may  market  their  products  to
healthcare professionals and may compete by discounting the prices of their products, including for example, the federal Anti-Kickback Statute, the federal
False Claims Act, the federal Health Insurance Portability and Accountability Act of 1996, state law equivalents to these federal laws that are meant to protect
against fraud and abuse and analogous laws in foreign countries. Violations of these laws are punishable by criminal and civil sanctions, including, but not
limited to, in some instances civil and criminal penalties, damages, fines, and exclusion from participation in federal and state healthcare programs, including
Medicare and Medicaid. Although we exercise care in structuring our sales and marketing practices and customer discount arrangements to comply with those
laws and regulations, we cannot assure that:

•

•

government officials charged with responsibility for enforcing those laws will not assert that our sales and marketing practices or customer discount
arrangements are in violation of those laws or regulations; or
government regulators or courts will interpret those laws or regulations in a manner consistent with our interpretation.

We have in place policies and procedures for compliance that we believe are at least as stringent as those set forth in the AdvaMed Code of Ethics which was
developed  by  AdvaMed,  a  trade  association  that  represents  the  medical  device  industry,  and  which  is  intended  to  represent  best  practices  with  respect  to
medical device companies' interactions with healthcare providers. We regularly train our sales and marketing personnel on our policies regarding sales and
marketing practices. Pursuant to the AdvaMed Code, we have certified our adoption of the AdvaMed Code. The sales and marketing practices of our industry
have  been  the  subject  of  increased  scrutiny  from  federal  and  state  government  agencies,  and  we  believe  that  this  trend  will  continue.  Various  hospital
organizations,  medical  societies  and  trade  associations  are  establishing  their  own  practices  that  may  require  detailed  disclosures  of  relationships  between
healthcare professionals and medical device companies or ban or restrict certain marketing and sales practices such as gifts and business meals. Since these
laws,  regulations  and  ultimate  enforcement  continue  to  evolve,  we  cannot  predict  with  certainty,  what,  if  any,  impact,  changes  to  them  may  have  on  our
business or our customers.

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Outside of the U.S. we are subject to privacy and data security regulations at the international, national and regional level, as well as on an industry specific
basis. For example, in Europe, we are subject to the EU General Data Protection Regulation ("GDPR") which is related to the collection, processing, storage,
transfer and use of personal data. In the U.S., we are subject to the California Consumer Privacy Act of 2018 (“CCPA”) and other similar laws in the United
States, at both the federal and state level. Noncompliance with GDPR could trigger fines of up to 4% of global annual revenues. In addition, we are subject to
the  new  China  Personal  Information  Protection  Law  that  went  into  effect  November  1,  2021  which  focuses  on  protecting  personal  information  and  cross
border transfers of the information. Compliance with these requirements, either individually or in the aggregate, may require changes in business practices
added complexity and additional management oversight. They also may complicate our clinical research activities, as well as product offerings that involve
transmission or use of clinical data. Non-compliance may result in proceedings against us by governmental or other entities and/or significant fines which
could negatively impact our reputation and adversely affect our business.

Should  we  delay  or  fail  to  comply  with  one  or  more  of  the  regulatory  requirements  we  could  have  reduced  sales,  increased  costs,  delays  to  new  product
introductions, enhancements or our strategic plans, or harm to our reputation or competitiveness, which could have a material adverse effect on our business
and financial results.

Our medical device products are subject to reporting requirements and recalls, even after receiving regulatory clearance, approval or certification, which could
harm our reputation, business and financial results.

After a device is placed on the market, numerous regulatory requirements apply, which require manufacturers to follow, among other things, design, testing,
production,  control,  documentation  and  other  quality  assurance  procedures  during  the  manufacturing  process;  labeling  regulations,  which  prohibit  the
promotion of products for unapproved or “off-label” uses and impose other restrictions on labeling; and medical device reporting regulations that require us to
report to FDA or similar governmental bodies in other countries if our products may have caused or contributed to a death or serious injury or malfunction in
a way that would be reasonably likely to contribute to death or serious injury if the malfunction were to recur. The FDA and similar governmental bodies in
other countries have the authority to require the recall of our products in the event of material deficiencies or defects in design or manufacture or in the event
that a product poses an unacceptable risk to health. We may, under own initiative, recall a product if a reasonable possibility of serious injury or any material
deficiency in a device is found, or withdraw a product to improve device performance or for other reasons.

Recalls of any of our products may divert managerial and financial resources and have an adverse effect on our financial condition and results of operations.
A  recall  could  harm  our  reputation  with  customers  and  consumers  which  could  reduce  the  sales  of  our  products.  In  addition,  the  FDA  or  other  foreign
governmental  agencies  may  implement  enforcement  actions  in  connection  with  a  recall  which  could  impair  our  product  offerings  and  be  harmful  to  our
business and financial results.

Certain of our products contain materials derived from animal sources and may become subject to additional regulation.

Certain of our products are derived from bovine or porcine tissue sources. As a result, we may experience difficulties in processing and producing our bovine
and porcine tissue products at scale, including problems related to yields, quality control and assurance, tissue availability, adequacy of control policies and
procedures and availability of skilled personnel.

With  respect  to  bovine,  among  other  products,  our  dermal  regeneration  products,  duraplasty  products,  wound  care  products,  bone  void  fillers,  nerve  and
tendon  repair  products  and  certain  other  products,  contain  material  derived  from  bovine  tissue.  In  2022,  43.3%  of  our  revenues  derived  from  products
containing material derived from bovine tissue. Products that contain materials derived from animal sources, including food, pharmaceuticals and medical
devices, are subject to scrutiny in the media and by regulatory authorities. Regulatory authorities are concerned about the potential for the transmission of
disease from animals to humans via those materials. This public scrutiny has been particularly acute in Japan and Western Europe with respect to products
derived from animal sources, because of concern that materials infected with the agent that causes bovine spongiform encephalopathy, otherwise known as
BSE or mad cow disease, may, if ingested or implanted, cause a variant of the human Creutzfeldt-Jakob Disease, an ultimately fatal disease with no known
cure. The World Organization for Animal Health recognizes the U.S. as having a negligible risk for BSE, which is the highest status available.

We take care to provide that our products are safe and free of agents that can cause disease. In particular, we qualified a source of collagen from a country
outside  the  U.S.  that  is  considered  BSE/TSE-free.  The  World  Health  Organization  classifies  different  types  of  bovine  tissue  for  relative  risk  of  BSE
transmission.  Deep  flexor  tendon  and  bovine  fetal  skin,  which  are  used  in  our  products,  are  in  the  lowest-risk  categories  for  BSE  transmission  and  are
therefore considered to have a negligible risk of containing the agent that causes BSE (an improperly folded protein known as a prion). Nevertheless, products
that contain materials derived from animals, including our products, could become subject to additional regulation, or even be banned in certain countries,
because of concern over the potential for the transmission of prions. Significant new regulations, or a ban of our products, could have a material, adverse
effect on our current business or our ability to expand our business.

Certain countries, such as Japan, China, Taiwan and Argentina, have issued regulations that require our collagen products be sourced from countries where no
cases of BSE have occurred, and the EU has requested that our dural replacement products and other products that are used in neurological tissue be sourced
from a country where no cases of BSE have occurred. Currently, we source bovine fetal hides from the U.S. and purchase tendon from the U.S. and New
Zealand. New Zealand has

25

never had a case of BSE. We received approval in the U.S., the EU, Japan, Taiwan, China, Argentina as well as other countries for the use of New Zealand-
sourced tendon in the manufacturing of our products. If we cannot continue to use or qualify a source of tendon from New Zealand or another country that has
never had a case of BSE, we could be prohibited from selling our collagen products in certain countries.

We are subject to current and potential future requirements relating to protection of the environment, such as hazardous materials regulations, which
may impose significant compliance or other costs on us.

Certain of our processes in manufacturing and research and development involve the controlled use of certain hazardous materials. In addition, we own and/or
lease a number of facilities at which hazardous materials have been used in the past. Finally, we have acquired various companies that historically have used
certain hazardous materials and that have owned and/or leased facilities at which hazardous materials have been used. For all of these reasons, we are subject
to federal, state, foreign, and local laws and regulations governing the use, manufacture, storage, transportation, handling, treatment, remediation, and disposal
of hazardous materials and certain waste products (“Environmental, Health, Safety and Transportation Laws”). Although we believe that our procedures for
handling,  transporting,  and  disposing  of  hazardous  materials  comply  with  the  Environmental,  Health,  Safety  and  Transportation  Laws,  such  laws  may  be
amended in ways that increase our cost of compliance, perhaps materially.

Furthermore,  the  potential  risk  of  accidental  contamination  or  injury  from  these  materials  cannot  be  eliminated,  and  there  is  also  a  risk  that  such
contamination previously has occurred in connection with one of our facilities or in connection with one of the companies we have purchased. In the event of
such an accident or contamination, we could be held liable for any damages that result and any related liability could exceed the limits or fall outside the
coverage of our insurance and could exceed our resources. We may not be able to maintain insurance on acceptable terms or at all.

Our business and operations are subject to risks related to climate change.

The long-term effects of global climate change present both physical risks (from the increased frequency of extreme weather conditions or natural disasters)
and transition risks (from regulatory requirements or technology changes). Such extreme weather conditions could pose physical risks to our facilities and
disrupt  operation  of  our  supply  chain  and  may  impact  operational  costs.  Concern  over  global  climate  change  could  result  in  new  legal  or  regulatory
requirements  designed  to  mitigate  the  effects  of  climate  change  on  the  environment.  If  such  laws  or  regulations  are  more  stringent  than  current  legal  or
regulatory requirements, we may experience increased compliance burdens and costs to meet the regulatory obligations and such measures may interrupt our
operations or the operations of our suppliers, potentially leading to higher costs, and therefore negatively impact our results of operations.

We are subject to requirements relating to information technology which could adversely affect our business.

If  we  are  unable  to  maintain  reliable  information  technology  systems  and  prevent  disruptions,  outages,  or  data  breaches,  we  may  suffer  regulatory
consequences in addition to business consequences. Our worldwide operations means that we are subject to laws and regulations, including data protection
and cyber security laws and regulations, in many jurisdictions. The variety of U.S. and international privacy and cybersecurity laws and regulations impacting
our operations are described in “Item 1. Business - Government Regulation - Other Factors - Data Privacy and Cybersecurity Laws and Regulations." We
have programs to ensure compliance with such laws and regulations. However, there is no guarantee that we will avoid enforcement actions by governmental
bodies. Enforcement actions may be costly and interrupt regular operations of our business. In addition, there has been a developing trend of civil lawsuits and
class actions relating to breaches of consumer data held by large companies or incidents arising from other cyber-attacks. While Integra has not been named in
any such suits, if a substantial breach or loss of data were to occur, we could become a target of such litigation.

If we do not retain our key personnel and attract and retain other highly skilled employees, our business could suffer.

If we fail to recruit, develop and retain the necessary personnel, our business and our ability to obtain new customers, develop new products and provide
acceptable levels of customer service could suffer. The success of our business is heavily dependent on the leadership of our key management personnel. Our
success  also  depends  on  our  ability  to  recruit,  develop  and  retain  and  motivate  highly  skilled  sales,  marketing,  manufacturing  and  scientific  personnel.
Competition  for  these  persons  in  our  industry  is  intense,  and  we  may  not  be  able  to  successfully  recruit,  train  or  retain  qualified  personnel.  We  are
experiencing  increasing  challenges  in  building  and  retaining  our  workforce  in  certain  markets,  where  pressure  from  inflation  and  competition  have
exacerbated turnover and retention trends continuing from the COVID-19 pandemic. Labor shortages and competition for qualified personnel could cause
disruptions in our business operations.

RISKS RELATED TO TAX AND DEBT

We may have additional tax liabilities.

We are subject to income taxes in the U.S. and many foreign jurisdictions and are commonly audited by various tax authorities. In the ordinary course of our
business, there are many transactions and calculations where the ultimate tax determination is uncertain. Significant judgment is required in determining our
worldwide  provision  for  income  taxes.  Although  we  believe  that  our  tax  estimates  are  reasonable,  the  final  determination  of  tax  audits  and  any  related
litigation could be materially different

26

from our historical income tax provisions and accruals. The results of an audit or litigation could have a material, adverse effect on our financial statements in
the period or periods for which that determination is made.

Changes in tax laws or exposures to additional tax liabilities could negatively impact the Company's operating results.

We are subject to income taxes, as well as taxes that are not income-based, in both the U.S. and many foreign jurisdictions. Taxes could significantly increase
due to changes in tax laws or changes in our interpretation of those laws. For example, the Organization for Economic Co-operation and Development, a global policy
forum, is developing a global tax framework that, if implemented, includes a global minimum tax rate of 15%. Taxes could also significantly increase due to changes
in accounting guidance. Our future effective tax rate could be unfavorably affected by numerous factors including a change in, or the interpretation of, tax rules
and regulations in the jurisdictions in which we operate (including changes in legislation currently being considered), a change in our geographic earnings
mix, and/or to the jurisdictions in which we operate, or a change in the measurement of our deferred taxes.

Our leverage and debt service obligations could adversely affect our business.

Our leverage and debt service obligations could adversely affect our business. As of December 31, 2022, our total consolidated external debt was
approximately $1.5 billion (See Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations and Note 5, Debt, to the
Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for a discussion of our consolidated external debt). We
may also incur additional indebtedness in the future. Our substantial indebtedness could have material, adverse consequences, including:

• making it more difficult for us to satisfy our financial obligations;
•

increasing our vulnerability to adverse economic, regulatory and industry conditions, and placing us at a disadvantage compared to our competitors
that are less leveraged;
limiting our ability to compete and our flexibility in planning for, or reacting to, changes in our business and the industry in which we operate; and
limiting our ability to borrow additional funds for working capital, capital expenditures, acquisitions and general corporate or other purposes.

•
•

Our  debt  service  obligations  will  require  us  to  use  a  portion  of  our  operating  cash  flow  to  pay  interest  and  principal  on  indebtedness  instead  of  for  other
corporate purposes, including funding future expansion of our business, acquisitions, and ongoing capital expenditures, which could impede our growth. In
addition, our ability to comply with, renegotiate or extend the Company’s debt obligations will depend on our operating and financial performance, which in
turn is subject to prevailing economic conditions and financial, business and other factors beyond our control. Any disruptions in our operations, the financial
markets, or the overall economy, including as a result of COVID-19, may adversely affect the availability and cost of credit to us and/or our ability to comply
with our existing obligations.

Changes in the calculation and or complete replacement of LIBOR could have an impact on our business.

The  United  Kingdom’s  Financial  Conduct  Authority  (“FCA”),  which  regulates  LIBOR,  announced  in  July  2017  that  it  will  no  longer  persuade  or  require
banks to submit rates for LIBOR. On March 5, 2021, the ICE Benchmark Administration, which administers LIBOR, and the FCA announced that all LIBOR
settings will either cease to be provided by any administrator, or no longer be representative immediately after December 31, 2021, for all non-U.S. dollar
LIBOR settings and one-week and two-month U.S. dollar LIBOR settings, and immediately after June 30, 2023 for the remaining U.S. dollar LIBOR settings.
We have multiple debt facilities which utilizes a variable rate equal to Eurodollar LIBOR rate as a component of our interest rate.

Management expects all LIBOR-based contracts to be replaced by the Secured Overnight Financing Rate (“SOFR”), which is calculated based on overnight
transactions under repurchase agreements backed by Treasury securities. The Alternative Reference Rates Committee, a group of private-market participants
convened  by  the  U.S.  Federal  Reserve  Board  and  the  New  York  Federal  Reserve,  has  recommended  the  use  of  SOFR  as  a  more  robust  reference  rate
alternative to LIBOR. The use of SOFR as a substitute for LIBOR is, however, voluntary and may not be suitable for all market participants. There can be no
assurance  that  the  replacement  rate  will  be  economically  equivalent  to  LIBOR,  which  could  result  in  higher  interest  rates  for  us  under  our  debt  facilities.
There is no guarantee that a transition from LIBOR to SOFR will not result in financial market disruptions, significant increases in benchmark rates, or our
borrowing costs, any of which could have an adverse effect on our business, results of operations and financial condition.

RISKS RELATED TO OUR INTELLECTUAL PROPERTY

Our  intellectual  property  rights  may  not  provide  meaningful  commercial  protection  for  our  products,  potentially  enabling  third  parties  to  use  our
technology or very similar technology and could reduce our ability to compete in the market.

To compete effectively, we depend, in part, on our ability to maintain the proprietary nature of our technologies and manufacturing processes, which includes
the ability to obtain, protect and enforce patents on our technology and to protect our

27

trade secrets. We own or have licensed patents that cover aspects of some of our product lines. Our patents, however, may not provide us with any significant
competitive advantage. Others may challenge our patents and, as a result, our patents could be narrowed, invalidated or rendered unenforceable. Competitors
may develop products similar to ours that our patents do not cover. In addition, the approval or rejection of patent applications may take several years and our
current and future patent applications may not result in the issuance of patents in the U.S. or foreign countries.

Our competitive position depends, in part, upon unpatented trade secrets, which we may be unable to protect.

Our  competitive  position  also  depends  upon  unpatented  trade  secrets,  which  are  difficult  to  protect.  We  cannot  assure  that  others  will  not  independently
develop  substantially  equivalent  proprietary  information  and  techniques  or  otherwise  gain  access  to  our  trade  secrets,  that  our  trade  secrets  will  not  be
disclosed or that we can effectively protect our rights to unpatented trade secrets.

In an effort to protect our trade secrets, we require our employees, consultants and advisors to execute confidentiality and invention assignment agreements
upon commencement of employment or consulting relationships with us. These agreements provide that, except in specified circumstances, all confidential
information developed or made known to the individual during the course of their relationships with us must be kept confidential. We cannot assure, however,
that  these  agreements  will  provide  meaningful  protection  for  our  trade  secrets  or  other  proprietary  information  in  the  event  of  the  unauthorized  use  or
disclosure of confidential information.

Our success will depend partly on our ability to operate without infringing or misappropriating the proprietary rights of others.

We may be sued for infringing the intellectual property rights of others. In addition, we may find it necessary, if threatened, to initiate a lawsuit seeking a
declaration from a court that we do not infringe the proprietary rights of others or that their rights are invalid or unenforceable. If we do not prevail in any
litigation, in addition to any damages we might have to pay, we would be required to stop the infringing activity (which could include a cessation of selling
the products in question) or obtain a license for the proprietary rights involved. Any required license may be unavailable to us on acceptable terms, if at all. In
addition, some licenses may be nonexclusive and allow our competitors to access the same technology we license.

If we fail to obtain a required license or are unable to design our products so as not to infringe on the proprietary rights of others, we may be unable to sell
some of our products, and this potential inability could have a material, adverse effect on our revenues and profitability.

We may be involved in lawsuits relating to our intellectual property rights and promotional practices, which may be expensive.

To  protect  or  enforce  our  intellectual  property  rights,  we  may  have  to  initiate  or  defend  legal  proceedings,  such  as  infringement  suits  or  opposition
proceedings,  against  or  by  third  parties.  In  addition,  we  may  have  to  institute  proceedings  regarding  our  competitors’  promotional  practices  or  defend
proceedings  regarding  our  promotional  practices.  Legal  proceedings  are  costly,  and,  even  if  we  prevail,  the  cost  of  the  legal  proceedings  could  affect  our
profitability. In addition, litigation is time-consuming and could divert management's attention and resources away from our business. Moreover, in response
to our claims against other parties, those parties could assert counterclaims against us.

RISKS RELATED TO GLOBAL OPERATIONS

If  any  of  our  facilities  or  those  of  our  suppliers  were  damaged  and/or  our  manufacturing  or  business  processes  interrupted,  we  could  experience  lost
revenues and our business could be seriously harmed.

Damage to our manufacturing, distribution, development and/or research facilities because of fire, extreme weather conditions, natural disaster, power loss,
communications  failure,  geopolitical  disruption,  unauthorized  entry  or  other  events,  such  as  a  flu  or  other  health  epidemic,  such  as  COVID-19,  could
significantly disrupt our operations, the operations of suppliers and critical infrastructure and delay or prevent product manufacture and shipment during the
time  required  to  repair,  rebuild  or  replace  the  damaged  facilities.  Certain  of  our  manufacturing  facilities  are  located  in  Puerto  Rico,  which  in  the  past  has
experienced both severe hurricanes and other natural disasters. Climate change may increase both the frequency and severity of extreme weather conditions
and  natural  disasters  and,  consequently,  risks  to  our  operations  and  growth.  Although  we  maintain  property  damage  and  business  interruption  insurance
coverage on these facilities, our insurance might not cover all losses under such circumstances, and we may not be able to renew or obtain such insurance in
the future on acceptable terms with adequate coverage or at reasonable costs.

We are exposed to a variety of risks relating to our international sales and operations.

We generate significant revenues outside the U.S. in multiple foreign currencies, and in U.S. dollar-denominated transactions conducted with customers who
generate  revenue  in  currencies  other  than  the  U.S.  dollar.  For  those  foreign  customers  who  purchase  our  products  in  U.S.  dollars,  currency  fluctuations
between the U.S. dollar and the currencies in which those

28

customers do business may have a negative impact on the demand for our products in foreign countries where the U.S. dollar has increased in value compared
to the local currency.

Since  we  have  operations  based  outside  the  U.S.  and  we  generate  revenues  and  incur  operating  expenses  in  multiple  foreign  currencies,  we  experience
currency exchange risk with respect to those foreign currency-denominated revenues and expenses. Our most significant currency exchange risk relates to
transactions conducted in Australian dollars, British pounds, Canadian dollars, Chinese yuan, Euros, Japanese yen, and Swiss francs.

We cannot predict the consolidated effects of exchange rate fluctuations upon our future operating results because of the number of currencies involved, the
variability  of  currency  exposure  and  the  potential  volatility  of  currency  exchange  rates.  Although  we  address  currency  risk  management  through  regular
operating  and  financing  activities,  and,  on  a  limited  basis,  through  the  use  of  derivative  financial  instruments,  those  actions  may  not  prove  to  be  fully
effective.  For  a  description  of  our  use  of  derivative  financial  instruments,  see  Note  6,  Derivative  Instruments  to  the  Notes  to  Consolidated  Financial
Statements (Part IV, Item 15 of this Annual Report on Form 10-K).

Our international operations subject us to laws regarding sanctioned countries, entities and persons, customs, import-export, laws regarding transactions in
foreign  countries,  the  U.S.  Foreign  Corrupt  Practices  Act  and  local  anti-bribery  and  other  laws  regarding  interactions  with  healthcare  professionals,  and
product  registration  requirements.  Among  other  things,  these  laws  restrict,  and  in  some  cases  prevent,  U.S.  companies  from  directly  or  indirectly  selling
goods,  technology  or  services  to  people  or  entities  in  certain  countries.  In  addition,  these  laws  require  that  we  exercise  care  in  structuring  our  sales  and
marketing practices and effecting product registrations in foreign countries.

The Russia-Ukraine conflict and resulting sanctions and export restrictions are creating barriers to doing business in Russia and adversely impacting global
supply chains. While we have no manufacturing, distribution or direct material suppliers in the region, we are closely monitoring the potential raw material or
supplier impact in both Russia and Ukraine. Materials like palladium and neon, which are both dependent on Russia supply, are part of broader semiconductor
shortages in industry. Additional sanctions, export restrictions, and potential countermeasures within Russia may lead to greater uncertainty and geopolitical
shifts in Asia that could cause additional adverse impacts on global supply chains and our business, results of operations, financial condition and cash flows.

The United Kingdom’s (“UK”) exit from the European Union on January 31, 2020, commonly referred to as Brexit, has caused, and may continue to cause
uncertainty in the global political markets. It is possible that Brexit could, among other things, affect the legal and regulatory environments, including the
regulatory landscape concerning medical devices, to which our business is subject, impose greater restrictions on imports and exports between the UK and the
EU and other parties, increase currency volatility and create economic and political uncertainty in the region.

As we seek to continue to expand and strengthen our international operations, we may experience difficulty in growing our sales in certain new markets and
other  international  markets  in  which  we  are  attempting  to  increase  our  presence  due  to,  among  other  things,  customer  acceptance,  undeveloped  and/or
unfamiliar distribution channels, regulatory restrictions and changes, and business knowledge of these markets.

From time to time, proposals are made to significantly change existing trade agreements and relationships between the U.S. and other countries. In recent
years, the U.S. government has implemented substantial changes to U.S. trade policies, including import restrictions, increased import tariffs and changes in
U.S. participation in multilateral trade agreements, such as the United States-Mexico-Canada Agreement to replace the former North American Free Trade
Agreement.  The  ongoing  global  economic  competition  and  trade  tensions  between  the  U.S.  and  China  has  resulted  in  the  U.S.  government  assessing
supplemental  tariffs  on  certain  goods  imported  from  China  and  China’s  assessment  of  retaliatory  tariffs  on  certain  imports  of  U.S.  goods  into  China.  In
addition, the United States has assessed or proposed supplemental tariffs and quantitative restrictions on U.S. imports of certain products from other countries
as well. Owing to the complex relationships between the U.S. and such other countries, political, diplomatic, military, or other events could result in business
disruptions, including increased regulatory enforcement against companies, tariffs, trade embargoes, export restrictions and the termination or modification of
existing trade agreements. The imposition of such restrictions could increase the cost of the Company’s products and the components and raw materials that
go into making them, require the Company to change its operations and the products it offers and negatively impact consumer confidence and spending, all of
which, both individually and in the aggregate, could materially and adversely affect our business, results of operations and financial condition.

GENERAL RISK FACTORS

Cyber-attacks or other disruptions to our information technology systems could adversely affect our business.

We  are  increasingly  dependent  on  sophisticated  information  technology  for  our  infrastructure  and  to  support  business  decisions.  Our  information  systems
require  an  ongoing  commitment  of  significant  resources  to  maintain,  protect,  and  enhance  existing  systems  and  develop  new  systems  to  keep  pace  with
continuing  changes  in  information  processing  technology,  evolving  systems  and  regulatory  standards,  the  increasing  need  to  protect  patient  and  customer
information, and changing customer

29

patterns. An experienced third party maintains the enterprise business system used to support our transaction processing, accounting and financial reporting,
and supply chain and manufacturing processes. Any significant breakdown, intrusion, interruption, corruption, or destruction of these systems, as well as any
data breaches, could have a material, adverse effect on our business.

Third parties may attempt to breach our systems and may obtain data relating to patients, proprietary or sensitive information. As a result of the COVID-19
pandemic, we may face increased cybersecurity risks due to our reliance on internet technology and the number of our employees who are working remotely,
which may create additional opportunities for cybercriminals to exploit vulnerabilities. If we, or third parties on whom we rely, fail to maintain or protect our
information systems and data integrity effectively, we could lose existing customers, have difficulty attracting new customers, suffer backlash from negative
public relations, have regulatory sanctions or penalties imposed, have increases in operating expenses, incur expenses or lose revenues as a result of a data
privacy breach, or suffer other adverse consequences.

We have programs, processes (including ongoing improvements) and technologies in place to prevent, detect, contain, respond to and mitigate security related
threats  and  potential  incidents.  Because  the  techniques  used  to  obtain  unauthorized  access  or  interrupt  services  change  frequently  and  can  be  difficult  to
detect, anticipating, identifying or preventing these threats or mitigating them if and when they occur, may be challenging. We are also dependent on third
party vendors to supply and/or support certain aspects of our information technology systems which may contain defects in design or manufacture or other
problems that could result in system disruption or unexpectedly compromise the information security of our own systems. In addition, as we grow in part
through new acquisitions we may face risks due to implementation, modification, or remediation of controls, procedures, and policies relating to data privacy
and  cybersecurity  at  the  acquired  business.  We  continue  to  consolidate  and  integrate  the  number  of  systems  we  operate,  and  to  upgrade  and  expand  our
information  system  capabilities  for  stable  and  secure  business  operations.  Despite  our  implementation  of  controls  to  protect  our  systems  and  sensitive,
confidential or personal data or information, we may be vulnerable to material security breaches, theft, misplaced, lost or corrupted data, employee errors
and/or malfeasance (including misappropriation by departing employees) that could potentially lead to the compromising of sensitive, confidential or personal
data  or  information,  improper  use  of  our  systems,  software  solutions  or  networks,  unauthorized  access,  use,  disclosure,  modification  or  destruction  of
information,  defective  products,  production  downtimes  and  operational  disruptions.  In  addition,  a  cyber-related  attack  could  result  in  other  negative
consequences, including damage to our reputation or competitiveness, remediation or increased protection costs, litigation or regulatory action.

Environmental, social and corporate governance (ESG) issues, including those related to climate change and sustainability, may have an adverse effect on our
business, financial condition and results of operations and damage our reputation.

There is an increasing focus from certain investors, customers, consumers, employees and other stakeholders concerning ESG matters. Additionally, public
interest and legislative pressure related to public companies’ ESG practices continue to grow. Consistent with these developments, we published our inaugural
ESG Report which includes performance highlights in key areas such as employee health and safety, diversity and inclusion, community impact, ethics and
compliance,  and  environmental  responsibility.  In  addition,  we  formally  expanded  Board  oversight  to  include  ESG  strategy  and  reporting.  If, however, our
ESG practices fail to meet regulatory requirements or investor, customer, consumer, employee or other stakeholders' evolving expectations and standards for
responsible  corporate  citizenship  in  areas  including  environmental  stewardship,  support  for  local  communities,  Board  of  Director  and  employee  diversity,
human  capital  management,  employee  health  and  safety  practices,  product  quality,  supply  chain  management,  corporate  governance  and  transparency,  our
reputation, brand and employee retention may be negatively impacted, and our customers and suppliers may be unwilling to continue to do business with us.

If we do not adapt to or comply with new regulations, or fail to meet evolving investor, industry or stakeholder expectations and concerns regarding ESG
issues, investors may reconsider their capital investment in our Company, and customers may choose to stop purchasing our products, which could have a
material adverse effect on our reputation, business or financial condition.

ITEM 1B. UNRESOLVED STAFF COMMENTS

As of the filing of this Annual Report on Form 10-K, we had no unresolved comments from the staff of the Securities and Exchange Commission that were
received not less than 180 days before the end of our 2022 fiscal year.

ITEM 2.

PROPERTIES

As of December 31, 2022, we lease approximately 166,991 square feet of space in Princeton, NJ, where we house our principal headquarters, sales operations,
and support functions. This lease expires in 2035.

30

We have key manufacturing and research facilities located in California, Indiana, Maryland, Massachusetts, New Jersey, Ohio, Puerto Rico, Tennessee, Utah,
France, Germany, Ireland and Switzerland. Our instrument procurement operations are located in Germany. Our primary distribution centers are located in
Kentucky, Nevada, Australia, Belgium, Canada, Italy, Japan, and China. In addition, we lease several smaller facilities to support additional administrative,
assembly, and distribution operations. Third parties own and operate the facilities in Nevada, Kentucky, Japan and Belgium. We own facilities in Saint Aubin
Le Monial, France, Rietheim-Weilheim, Germany and Ohio and we lease all of our other facilities. We also have repair centers in Ohio, Australia, France,
Japan, China and Germany, and field service presence in Canada, Dubai, India, Italy, Netherlands, Singapore, Thailand and United Kingdom.

Our manufacturing facilities are registered with the FDA. Our facilities are subject to FDA inspection to ensure compliance with Quality System regulations.
For further information regarding the status of FDA inspections, see the Item 1. Business –Government Regulation and Compliance Item 7. Management's
Discussion and Analysis of Financial Condition and Results of Operations – FDA Matters in this Annual Report on Form 10-K.

ITEM 3.

LEGAL PROCEEDINGS

Information pertaining to legal proceedings can be found in Note 15, Commitment and Contingencies, to the Notes to Consolidated Financial Statements (Part
IV, Item 15 of this Annual Report on Form 10-K).

ITEM 4.

MINE SAFETY DISCLOSURES

Not applicable.

ITEM 5.

MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF
EQUITY SECURITIES

PART II 

Market Information, Holders and Dividends

Our common stock trades on The Nasdaq Global Select Market under the symbol “IART.” The number of stockholders of record as of February 21, 2023 was
approximately 779, which includes stockholders whose shares were held in nominee name.

Dividend Policy

We have not paid any cash dividends on our common stock since our formation. Our Senior Credit Facility (as defined below) limits the amount of dividends
that we may pay. Any  future  determinations  to  pay  cash  dividends  on  our  common  stock  will  be  at  the  discretion  of  the  Board  and  will  depend  upon  our
financial condition, results of operations, cash flows and other factors deemed relevant by the Board.

Sales of Unregistered Securities

There were no sales of unregistered securities during the years ended December 31, 2022, 2021 or 2020.

Sale of Registered Securities

There were no sales of registered securities during the years ended December 31, 2022, 2021 or 2020.

Issuer Purchases of Equity Securities

On  January  12,  2022,  the  Company  entered  into  a  $125.0  million  accelerated  share  repurchase  ("2022  ASR")  and  received  1.48  million  shares  of  the
Company common stock at inception of the 2022 ASR, which represented approximately 80% of the expected total shares under the 2022 ASR. On March
24, 2022, the early exercise provision was exercised by 2022 ASR counterparty. Upon settlement on March 24, 2022, the Company received an additional
0.46 million shares determined using the volume-weighted average price of the Company's common stock during the term of the 2022 ASR.

On April 26, 2022, the Board of Directors authorized the Company to repurchase up to $225.0 million of the Company’s common stock. The program allows
the  Company  to  repurchase  its  shares  opportunistically  from  time  to  time.  The  repurchase  authorization  expires  in  December  2024.  This  stock  repurchase
authorization replaces the previous $225 million stock repurchase authorization, of which $100 million remained authorized at the time of its replacement,
and which was otherwise set to expire on December 31, 2022. Purchases may be affected through one or more open market transactions, privately negotiated
transactions, transactions structured through investment banking institutions, or a combination of the foregoing.

On January 26, 2023, the Company entered into a $150 million accelerated share repurchase ("2023 ASR") and received 2.1 million shares of the Company
common  stock  at  inception  of  the  2023  ASR,  which  represented  approximately  80%  of  the  expected  total  shares  of  under  the  2023  SAR.  The  remaining
repurchase transactions are expected to be completed in the first half of 2023.

31

For the year ended December 31, 2021, there were no repurchases of the Company’s common stock as part of the share repurchase authorization.

See Note 8, Treasury Stock to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for further details.

Securities Authorized for Issuance under Equity Compensation Plan

The information required by this item regarding our equity compensation plans is incorporated herein by reference to Item 12 of Part III of this Annual Report
on Form 10-K.

Stock Performance Graph

The graph below compares the five-year total return to stockholders on our common stock with the return of the Standard & Poor’s (S&P) 500 Stock Index
and the S&P Healthcare Equipment Index. The Company’s cumulative shareholder return is based on an investment of $100 on December 31, 2017 and is
compared to the cumulative total return of the S&P indices mentioned above over the period with a like amount invested.

Note: The stock price performance shown on the graph above is not indicative of future price performance. This graph shall not be deemed filed for purposes
of Section 18 of the Exchange Act or otherwise subject to the liabilities of that section nor shall it be deemed incorporated by reference in any filing under the
Securities Act or the Exchange Act, regardless of any general incorporation language in such filing.

ITEM 6.

[Reserved]

ITEM 7.

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

32

The  following  discussion  and  analysis  provides  information  management  believes  to  be  relevant  to  understanding  our  financial  condition  and  results  of
operations. For a full understanding of financial condition and results of operations, it should be read together with the selected consolidated financial data
and  our  financial  statements  with  the  related  notes  appearing  elsewhere  in  this  report.  The  discussion  focuses  on  our  financial  results  for  the  year  ended
December 31, 2022 and 2021. The comparison of fiscal 2021 to 2020 has been omitted from this Form 10-K, but can be referenced in our Form 10-K for the
fiscal year ended December 31, 2021—“Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations” filed with the SEC
on February 24, 2022.

We have made statements in this report which constitute forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E
of the Exchange Act. The Company’s actual results could differ materially from those anticipated in these forward-looking statements as a result of many
factors, including but not limited to those set forth under Item 1A. Risk Factors. We have made statements in this report which constitute forward-looking
statements within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange Act. These forward-looking statements are subject to a
number of risks, uncertainties and assumptions about the Company and other matters. Please refer to “Special Note Regarding Forward-Looking Statements”
and Item 1A. Risk Factors for a discussion of the factors that could cause actual results to differ materially from those projected in these statements. The
following information concerning our business, results of operations and financial condition should also be read in conjunction with the information included
under Item 1. Business, Item 1A. Risk Factors and Item 15. Financial Statements and Supplementary Data.

GENERAL

Integra LifeSciences is a global leader in regenerative tissue technologies and neurological solutions dedicated to limiting uncertainty for clinicians so they
can  focus  on  providing  the  best  patient  care.  Founded  in  1989  with  the  acquisition  of  an  engineered  collagen  technology  platform  used  to  repair  and
regenerate  tissue,  Integra  LifeSciences  Holdings  Corporation  common  stock  trades  on  the  Nasdaq  Global  Select  Market  (“Nasdaq”)  under  the  symbol
“IART.” Integra has developed numerous product lines from this technology for applications ranging from burn and deep tissue wounds to the repair of dura
mater  in  the  brain,  as  well  as  nerves  and  tendons.  The  Company  has  expanded  its  base  regenerative  technology  business  to  include  surgical  instruments,
neurosurgical  products  and  advanced  wound  care  through  global  acquisitions  and  product  development  to  meet  the  evolving  needs  of  its  customers  and
enhance patient care.

Integra  manufactures  and  sells  medical  technologies  and  products  in  two  reportable  business  segments:  Codman  Specialty  Surgical  ("CSS")  and  Tissue
Technologies  ("TT").  The  CSS  segment,  which  represents  approximately  two-thirds  of  our  total  revenue,  consists  of  market-leading  technologies  and
instrumentation used for a wide range of specialties, such as neurosurgery, neurocritical care and otolaryngology. We are the world leader in neurosurgery and
one of the top three providers in instruments used in precision, specialty, and general surgical procedures. Our TT segment generates about one-third of our
overall revenue and focuses on three main areas: complex wound surgery, surgical reconstruction, and peripheral nerve repair.

We have key manufacturing and research facilities located in California, Indiana, Maryland, Massachusetts, New Jersey, Ohio, Puerto Rico, Tennessee, Utah,
France, Germany, Ireland and Switzerland. We source most of our handheld surgical instruments and dural sealant products through specialized third-party
vendors.

Integra is committed to delivering high quality products that positively impact the lives of millions of patients and their families. We focus on four key pillars
of  our  strategy:  1)  enabling  an  execution-focused  culture,  2)  optimizing  relevant  scale,  3)  advancing  innovation  and  agility,  and  4)  leading  in  customer
experience. We believe that by sharpening our focus on these areas through improved planning and communication, optimization of our infrastructure, and
strategically aligned acquisitions, we can build scale, increase competitiveness and achieve our long-term goals.

To this end, the executive leadership team has established the following key priorities aligned to the following areas of focus:

Strategic Acquisitions. An important part of the Company's strategy is pursuing strategic transactions and licensing agreements that increase relevant scale in
the clinical areas in which Integra competes. Our growth strategy includes the acquisition of businesses, assets or products lines to increase the breadth of our
offerings, the reach of our product portfolios and drive relevant scale to our customers. On December 6, 2022, the Company completed the acquisition of SIA,
which  develops,  markets  and  sells  DuraSorb,  a  resorbable  synthetic  matrix  for  plastic  and  reconstructive  surgery.  This  acquisition  will  advance  Integra’s
global  strategy  in  breast  reconstruction,  expanding  plans  to  access  the  U.S.  market  where  SIA  is  pursuing  pre-market  approval  for  use  in  IBBR.  We  also
continued to advance the development of pioneering neurosurgical technologies with the expansion our product offering of regenerative technologies from our
2021 ACell acquisition. See Note 4, Acquisitions and Divestitures, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report
on Form 10-K) for additional details.

33

Portfolio Optimization and New Product Introductions. We are investing in innovative product development to drive a multi-generational pipeline for our key
product  franchises.  Our  product  development  efforts  span  across  our  key  global  franchises  focused  on  potential  technological  innovations  for  significant
returns on investment. In addition to new product development, we are funding studies to gather clinical evidence to support launches, ensure market access
and improve reimbursement for existing products. In addition to acquisitions and organic reinvestment, we continually look to optimize our portfolio towards
higher growth and higher margin businesses. As such, we may opportunistically divest businesses or discontinue products where we see limited runway for
future value creation in line with our aspirations due in part to changes in the market, business fundamentals or the regulatory environment.

Commercial Channel Investments. Investing in our sales channels is a core part of our strategy to create specialization and greater focus on reaching new and
existing customers and addressing their needs. To support our commercial efforts in Tissue Technologies, we utilize a two-tier specialist model to increase our
presence  in  focused  segments  to  help  serve  the  evolving  needs  of  our  customers.  In  addition,  we  continue  to  build  upon  our  leadership  brands  across  our
product franchises in both CSS and TT to engage customers through enterprise-wide contracts with leading hospitals, integrated delivery networks and global
purchasing  organizations  in  the  United  States.  Internationally,  we  have  increased  our  commercial  resources  significantly  in  key  emerging  markets  and  are
making investments to support our sales organization and maximize our commercial opportunities. Domestically, we have also increased our TT sales force in
the  United  States  to  support  the  expanded  regenerative  tissue  product  portfolio  that  includes  ACell  products.  These  investments  in  our  international  and
domestic sales channel position us well for expansion and long-term growth.

Customer Experience. We aspire to be ranked as a best-in-class provider and are committed to strengthening our relationships with all customers. We continue
to invest in technologies, systems and processes to enhance the customer experience. In 2022, we outsourced certain transactional back-office finance and
customer  service  activities  to  enhance  customer  quality,  build  scale  for  future  growth,  and  capture  cost  efficiencies.  We  also  launched  digital  tools  and
programs, resources and virtual product training to drive continued customer familiarity with our growing portfolio of medical technologies globally. .

New Product Introductions and Research and Development Updates

We  continue  to  invest  in  collecting  clinical  evidence  to  support  the  Company's  existing  products  and  new  product  launches,  and  to  ensure  that  we  obtain
market access for broader and more cost-effective solutions.

In 2022, we made progress to several enhancements to our CUSA Clarity Tissue Ablation System. The extended laparoscopic tip was launched in the U.S. to
enhance laparoscopic liver procedures. In addition, a single-sided bone tip received 510(k) clearance. Commercial launch is expected in the first quarter of
2023. We continue to update our CUSA Clarity platform by incorporating new ultrasonic handpiece and integrated electrosurgical capabilities.

In each area, we continue to benefit from products launched over the past several years, including our new electrosurgery generator and irrigator system, an
innovative customer-centric toolkit for our Certas  Plus Programmable Valve along with additional shunt configurations. In Japan, we are experiencing strong
growth as a result of the successful launch of DuraGen in mid-2019, which is the first and only collagen xenograft approved for use as a dural substitute in the
country.

®

In 2022, we continued to advance the two early-stage technology platforms we acquired in 2019. Through the acquisition of Arkiss, we added a platform
technology, CerebroFlo EVD, which is a catheter with Endexo technology, a permanent additive designed to reduce the potential for catheter obstruction due
to thrombus formation. The CerebroFlo EVD Catheter has demonstrated an average of 99% less thrombus accumulation onto its surface, in vitro, compared to
a  market  leading  EVD  catheter.  In  2019,  we  also  acquired  Rebound  Therapeutics  which  specialized  in  a  single-use  medical  device,  known  as  Aurora
Surgiscope, which is the only tubular retractor system designed for cranial surgery with an integrated access channel, camera and lighting. In 2021, we began
and continued to conduct a limited clinical launch of the Aurora Surgiscope for use in minimally invasive neurosurgery as well as initiated a registry called
MIRROR to collect data on early surgical intervention using this same technology platform for the treatment of ICH. In 2022, we have continued to execute
on  our  growth  initiatives.  We  launched  the  Aurora  Evacuator  with  Coagulation  device  in  the  U.S.,  designed  to  be  used  in  conjunction  with  our  Aurora
Surgiscope to safely address and evacuate blood in the brain caused by hemorrhagic stroke. 

We are focused on the development of core clinical applications in our electromechanical technologies portfolio. In June 2022, we launched the Neutus  EVD
system, our first EVD in China. The Neutus EVD system is manufactured in China by Shanghai Haoju Medical Technology Co., Ltd. under an exclusive
distribution arrangement. The device is used in the management of CSF and is highly complementary to our Bactiseal  catheter and advanced intercranial
pressure monitoring products. In 2021, we launched our CereLink ICP Monitor System in the U.S. and Europe direct markets and continued the global rollout
in  the  first  half  of  2022.  CereLink  provides  enhanced  accuracy,  usability  and  advanced  data  presentation  that  provides  clinicians  with  uncompromised,
advanced  continuous  ICP  monitoring  that  until  now,  has  not  been  available  when  treating  patients  with  traumatic  brain  injuries.  Refer  below  to  the
information appearing under the FDA Matters heading for additional information on the voluntary recall of the CereLink ICP Monitor System.

®

®

34

Within  our  TT  segment,  in  2022,  we  launched  NeuraGen  3D  Nerve  Guide  Matrix,  a  resorbable  implant  for  repair  of  peripheral  nerve  discontinuities  and
engineered  to  create  an  optimized  environment  for  nerve  regeneration.  During  2021,  we  completed  one  of  the  largest  diabetic  foot  ulcers  ("DFU"),
randomized controlled trials of the PriMatrix Dermal Repair Scaffold for the management of DFU. This multi-center study enrolled more than 225 patients
with chronic DFU's over the course of 12-week treatments and 4-week follow-up phases. The results of this study, which was published in the Journal of
Wound Care, demonstrated that PriMatrix plus standard of care SOC consisting of sharp debridement, infection elimination, use of dressings and offloading
was significantly more likely to achieve complete wound closure compared with SOC alone, with a median number of one application of the product. During
2020, we announced positive clinical and economic data on Integra  Bilayer Wound Matrix ("IBWM") in complex lower extremity reconstruction based on
two  retrospective  studies  recently  published  in  Plastic  and  Reconstructive  Surgery,  the  official  journal  of  the  American  Society  of  Plastic  Surgeons.  As
surgeons look for ways to efficiently and effectively repair and close wounds, IBWM helps address the efficiency needed in operating rooms by reducing both
the operating time and costs to hospitals and patients.

®

FDA Matters

On  August  18,  2022,  the  Company,  after  consultation  with  the  FDA  and  other  regulatory  authorities  outside  of  the  United  States,  initiated  an  immediate
voluntary global product removal of all CereLink intracranial pressure monitors as a result of customer reports about monitors whose pressure readings were
out  of  range.  The  Company  believes  that  the  out-of-range  readings  are  principally  caused  by  electrical  interference  from  the  external  environment  and/or
interference from a component on the circuit board of the monitor. These out-of-range readings have occurred at a low incidence rate and at a limited number
of sites; however, out of an abundance of caution, the Company removed all CereLink monitors from the field.

The Company Is continuing its investigation into the matter in order to remedy the observed issue and plans to resume shipment of the CereLink monitors as
soon as any such issues have been resolved. Based on outlook for returning the product to market and feedback from customers, the Company recorded a $1.9
million provision for product returns, as a reduction of net revenue, and a $0.8 million rework accrual in cost of goods sold in 2022.

We manufacture and distribute products derived from human tissue for which FDA has specific regulations governing human cells, tissues and cellular and
tissue-based products ("HCT/P"). An HCT/P is a product containing or consisting of human cells or tissue intended for transplantation into a human patient.
Refer to Item 1. Business and Item 1A. Risk Factors for further details around these FDA regulations and their potential effect on the Company's portfolio of
morselized amniotic material-based products as well as the impact on consolidated revenues.

On March 7, 2019, TEI Biosciences, Inc. ("TEI"), a wholly-owned subsidiary of the Company received a Warning Letter (the “Warning Letter”), dated March
6,  2019,  from  the  FDA.  The  warning  letter  related  to  quality  systems  issues  at  TEI's  manufacturing  facility  located  in  Boston,  Massachusetts.  The  letter
resulted from an inspection held at that facility in October and November 2018 and did not identify any new observations that were not already provided in
the Form 483 that followed the inspection. The Company submitted its initial response to the FDA Warning Letter on March 28, 2019 and provides regular
progress  reports  to  the  FDA  as  to  its  corrective  actions  and,  since  the  conclusion  of  the  inspection,  has  undertaken  significant  efforts  to  remediate  the
observations and continues to do so. On October 28, 2021 the FDA initiated an inspection of the facility and at the conclusion of the inspection issued a FDA
Form  483  on  November  12,  2021  (the  "2021  Form  483").  The  Company  provided  an  initial  response  to  the  inspection  observations  and  will  continue  to
provide responses to FDA. The Warning Letter and the 2021 FDA Form 483 do not restrict the Company’s ability to manufacture or ship products or require
the recall of any products, nor do they restrict our ability to seek FDA 510(k) clearance of products. Additionally, premarket approval applications for Class
III devices to which the Quality System regulation violations are reasonably related will not be approved until the violations have been corrected. The TEI
Boston  facility  manufactures  extracellular  bovine  matrix  products.  We  cannot  give  any  assurances  that  the  FDA  will  be  satisfied  with  our  response  to  the
Warning Letter or as to the expected date of the resolution of the matters included in the letter. Until the issues cited in the letter are resolved to the FDA’s
satisfaction, the FDA may initiate additional regulatory action without further notice. Any adverse regulatory action, depending on its magnitude, may restrict
us  from  effectively  manufacturing,  marketing  and  selling  our  products  and  could  have  a  material  adverse  effect  on  our  business,  financial  condition  and
results of operations.

Revenues of products manufactured in the TEI Boston facility for the year ended December 31, 2022 were approximately 5.3% of consolidated revenues.

35

ACQUISITIONS & DIVESTITURES

Acquisitions

Our  growth  strategy  includes  the  acquisition  of  businesses,  assets  or  products  lines  to  increase  the  breadth  of  our  offerings  and  the  reach  of  our  product
portfolios  and  drive  relevant  scale  to  our  customers.  As  a  result  of  several  acquisitions  from  2021  through  2022,  our  financial  results  for  the  year  ended
December 31, 2022 may not be directly comparable to those of the corresponding prior-year periods. See Note 4, Acquisitions and Divestitures, of the Notes
to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for a further discussion.

Surgical Innovation Associates, Inc.

On December 6, 2022, the Company completed its acquisition of SIA for an acquisition purchase price of $51.5 million. In addition to the purchase price, the
acquisition includes two separate contingent considerations payments, which are dependent on 1) achieving certain revenue-based performance milestones in
2023, 2024, and 2025 (up to $50M in additional payments), as well as 2) the approval by the FDA of the PMA application for DuraSorb for certain uses by
certain timing targets (up to $40M in additional payments). SIA was a privately-held company whose core technology, DuraSorb is a fully resorbable scaffold
of a globally accepted polymer, cleared for use in hernia repair, abdominal wall, and other soft tissue reinforcement. DuraSorb sales will be reported within
Integra’s  TT  segment  as  part  of  its  Wound  Reconstruction  and  Care  franchise.  See  Note  4,  Acquisitions  and  Divestitures,  to  the  Notes  to  Consolidated
Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for details.

ACell Inc.

On January 20, 2021, the Company acquired ACell for an acquisition purchase price of $306.9 million plus contingent consideration obligations of up to $100
million, that may be payable upon achieving certain revenue-based performance milestones in 2022, 2023 and 2025. ACell was a privately-held company that
offered  a  portfolio  of  regenerative  products  for  complex  wound  management,  including  developing  and  commercializing  products  based  on  MatriStem
Urinary Bladder Matrix, a technology platform derived from porcine urinary bladder extracellular matrix. See Note 4, Acquisitions and Divestitures,  to  the
Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for additional details.

Divestiture

On August 31, 2022, the Company completed the sale of its TWC business to Gentell for $28.8 million, which consists of $27.8 million in cash plus $1.0
million in contingent consideration which may be received upon achieving certain revenue-based performance milestones two years after the closing date.
The proceeds from the sale of the TWC business of $27.8 million is presented in the consolidated statement of cash flows net of cash transferred of $3.5
million and other transaction fees. The transaction included the sale of the Company's TWC products, such as sponges, gauze and conforming bandages, and
certain  advanced  wound  care  dressings,  such  as  supportive,  calcium  alginate,  hydrogel,  and  foam  dressings.  In  connection  with  the  sale,  the  Company
recognized $0.6 million as a gain from the sale of business in the consolidated statement of operations for year ended December 31, 2022. The transaction is
subject to final working capital adjustments. See Note 4, Acquisitions and Divestitures, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of
this Form 10-K) for details.

On  January  4,  2021,  the  Company  completed  its  sale  of  its  Extremity  Orthopedics  business  to  Smith  &  Nephew.  The  transaction  included  the  sale  of  the
Company's  upper  and  lower  Extremity  Orthopedics  product  portfolio,  including  ankle  and  shoulder  arthroplasty  and  hand  and  wrist  product  lines.  The
Company received an aggregate purchase price of $240.0 million from Smith & Nephew and concurrently paid $41.5 million to the Consortium of Focused
Orthopedists, LLC ("CFO"), effectively terminating the licensing agreement between Integra and CFO relating to the development of shoulder arthroplasty
products. The Company recognized a gain of $41.8 million in connection with the sale that is presented in "Gain from the sale of business" in the consolidated
statement of operations for the year ended December, 31, 2021. See Note 4, Acquisitions and Divestitures of the Notes to Consolidated Financial Statements
(Part IV, Item 15 of this Annual Report on Form 10-K) for details.

36

OPTIMIZATION AND INTEGRATION ACTIVITIES

As a result of our ongoing acquisition strategy and significant growth in recent years, we have undertaken cost-saving initiatives to consolidate manufacturing
operations, distribution facilities and transfer activities, eliminate duplicative positions, realign various sales and marketing activities, and expand and upgrade
production capacity for our regenerative technology products. These efforts are expected to continue and while we expect a positive impact from ongoing
restructuring, integration, and manufacturing transfer and expansion activities, such results remain uncertain. In support of our continued focus on product
margins  during  2022,  we  closed  a  manufacturing  facility  located  in  France  and  began  the  transfer  of  production  to  the  Company’s  existing  Switzerland
facility. The transfer completed in the fourth quarter of 2022. In 2022, we outsourced certain transactional back-office finance and customer service activities
to enhance customer quality, build scale for future growth, and capture cost efficiencies. This transition also completed in the fourth quarter of 2022. While
the transition was complete in 2022, we are continuing to work with our outsource provider to transform our processes and gain efficiencies.

RESULTS OF OPERATIONS

Executive Summary

Net income for the year ended December 31, 2022 was $180.6 million, or $2.16 per diluted share, compared to $169.1 million, or $1.98 per diluted share for
the year ended December 31, 2021.

Income before taxes includes the following special charges: 

Dollars in thousands
Acquisition, divestiture and integration-related charges 
Structural optimization charges
EU medical device regulation

(1)

Total

$

Years Ended December 31,

2022

2021

(18,849) $
23,072 
45,147 
49,370 

(11,712)
20,762 
24,375 
33,425 

(1)

 See Note 4, Acquisitions and Divestitures of the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for details.

The items reported above are reflected in the consolidated statements of operations as follows:

Dollars in thousands
Cost of goods sold
Research and development
Selling, general and administrative
Gain from the sale of business
Other (income) expense
Total

$

Years Ended December 31,

2022

2021

11,722  $
21,882 
20,584 
(644)
(4,174)
49,370 

32,334 
17,487 
31,013 
(41,798)
(5,611)
33,425 

We typically define special charges as items for which the amounts and/or timing of such expenses may vary significantly from period to period, depending
upon our acquisition, divestiture, integration and restructuring activities, and for which the amounts are non-cash in nature, or for which the amounts are not
expected  to  recur  at  the  same  magnitude.  We  believe  that  given  our  ongoing  strategy  of  seeking  acquisitions,  our  continuing  focus  on  rationalizing  our
existing manufacturing and distribution infrastructure and our continuing review of various product lines in relation to our current business strategy, some of
the special charges discussed above could recur with similar materiality in the future.

We believe that the separate identification of these special charges provides important supplemental information to investors regarding financial and business
trends  relating  to  our  financial  condition  and  results  of  operations.  Investors  may  find  this  information  useful  in  assessing  comparability  of  our  operating
performance from period to period, against the business model objectives that management has established, and against other companies in our industry. We
provide this information to investors so that they can analyze our operating results in the same way that management does and to use this information in their
assessment of our core business and valuation of Integra.

37

 
 
Revenues and Gross Margin

Our revenues and gross margin on product revenues were as follows:

Dollars in thousands
Segment Net Sales
Codman Specialty Surgical
Tissue Technologies
Total revenues
Cost of goods sold
Gross margin on total revenues

Gross margin as a percentage of total revenues

Revenues

Years Ended December 31,

2022

2021

$

$

1,019,564 
538,102 
1,557,666 
587,355 
970,311 

$

$

1,025,232 
517,216 
1,542,448 
597,808 
944,640 

62.3 %

61.2 %

For the year ended December 31, 2022, total revenues increased by $15.2 million, or 1.0%, to $1,557.7 million from $1,542.4 million during the prior year.
This increase is inclusive of an unfavorable foreign currency impact of $37.9 million, as well as a $10.2 million decrease that impacts both domestic and
international revenues, related to the divestiture of the TWC business. Excluding the impacts of these items, domestic revenues increased by $41.6 million, or
3.8%. International revenues increased by $21.7 million or 4.8%.

In the CSS segment, revenues were $1,019.6 million which was a decrease of $5.7 million, or 0.6% as compared to the prior-year period. This increase is
inclusive of a $34.1 million unfavorable foreign currency impact on revenue. Excluding the impact of foreign currency, the CSS segment revenues increased
$28.4 million as compared to the prior year period. This increase was driven primarily by low single digits growth in both our Neurosurgery and Instruments
portfolios as compared to the same period in the prior year. The increase in our Neurosurgery portfolio was driven primarily by growth in advanced energy
and CSF management, partially offset by the voluntary recall of the CereLink ICP monitoring system.

In  the  TT  segment,  revenues  were  $538.1  million,  which  was  an  increase  of  $20.9  million,  or  4.0%  as  compared  to  the  prior-year  period..  Excluding  the
impact of foreign currency of $3.8 million and the divestiture impact of TWC of $10.2 million, the TT segment revenues in the third quarter increased by
$34.9 million. This increase was driven by mid-single digit increases in our Wound Reconstruction business, led by Integra  Dermal Matrices, SurgiMend and
ACell MicroMatrix and low double digit increased in our Private Label business driven by higher customer demand and favorable order timing.

®

Gross Margin

Gross margin was $970.3 million for the year ended December 31, 2022, an increase of $25.7 million from $944.6 million for the same period last year. Gross
margin  as  a  percentage  of  revenues  was  62.3%  in  2022  and  61.2%  in  2021.  The  increase  in  gross  margin  percentage  was  due  to  higher  revenues  and  a
reduction  of  inventory  step  up  amortization  in  connection  with  the  acquisition  of  ACell  in  the  prior  year.  These  were  partially  offset  by  CereLink  recall
impacts, unfavorable regional mix, and higher material and labor costs.

Operating Expenses

The following is a summary of operating expenses as a percent of total revenues: 

Research and development
Selling, general and administrative
Intangible asset amortization
 Total operating expenses

Years Ended December 31,

2022

2021

6.5 %
39.6 %
0.9 %
47.0 %

6.0 %
41.3 %
1.1 %
48.4 %

Total  operating  expenses,  which  consist  of  research  and  development,  selling,  general  and  administrative,  and  intangible  asset  amortization  expenses,
decreased by $16.0 million or 2.1% to $731.4 million in 2022, compared to $747.4 million in the prior year. The decrease in operating expenses is due to
lower selling, general and administrative costs and amortization partially offset by higher R&D spending.

38

 
 
 
 
The Company continues to manage and prioritize its operating costs to increase organic investments that will drive long-term growth including the support of
new product development and introductions, clinical studies, geographic expansion and targeted U.S. sales channel expansion.

Research and Development

Research and development expenses for the year ended December 31, 2022 increased by $8.1 million as compared to the prior year. This increase in spending
resulted  from  additional  spending  on  new  product  development,  clinical  studies  and  spending  related  to  the  EU  Medical  Device  Regulation  compliance
activities.

Selling, General and Administrative

Selling, general and administrative expenses for the year ended December 31, 2022 decreased by $21.1 million as compared to the prior year driven primarily
by the $18.1 million reduction in fair value of contingent consideration for ACell. The remainder of the decrease is a result of reduced employee related costs
and stock-based compensation, partially offset by increased selling costs on commissions and investment in sales force expansion.

Intangible Asset Amortization

Amortization expense (excluding amounts reported in cost of product revenues for technology-based intangible assets) in 2022 was $13.9 million compared to
$16.9 million in 2021 primarily due to a reduction associated with the end of the amortization period for a certain customer relationship intangible asset. In
addition, there was a decrease in amortization expense as a result of intangible assets sold with the TWC divestiture.

We may discontinue certain products in the future as we continue to assess the profitability of our product lines. As our profitability assessment evolves, we
may make further decisions about our trade names and incur additional impairment charges or accelerated amortization. We expect total annual amortization
expense to be approximately $82.3 million in 2023, $81.7 million in 2024, $81.7 million in 2025, $81.5 million in 2026, $79.6 million in 2027 and $551.6
million thereafter.

Non-Operating Income and Expenses

The following is a summary of non-operating income and expenses:

Dollars in thousands
Interest income
Interest expense
Gain from sale of business
Other income, net

Total non-operating income and expense

Interest Income

Years Ended December 31,

2022

2021

$

$

11,917  $
(49,594)
644 
12,007 
(25,026) $

6,737 
(50,395)
41,798 
19,307 
17,447 

Interest income for the year ended December 31, 2022 increased by $5.2 million as compared to the same period last year primarily due to higher interest
rates in 2022 compared to 2021.

Interest Expense

Interest expense for the year ended December 31, 2022 decreased by $0.8 million as compared to the same period last year primarily from a lower outstanding
borrowing on the Senior Secured Credit Facility partially offset by increased interest rates.

Gain from the sale of businesses

On August 31, 2022, the Company completed its previously announced sale of its TWC business to Gentell and recognized $0.6 million as a gain from the
sale of the business for the year ended December 31, 2022. On January 4, 2021, the Company completed its sale of its Extremity Orthopedics business and
recognized a gain of $41.8 million in the prior year.

Other Income, Net

Other income, net for the year ended December 31, 2022 decreased by $7.3 million. This was primarily due to due unfavorable impact of foreign exchange, as
well as lower income associated with the transition services agreement invoicing from the divestiture of the Extremity Orthopedics business.

39

 
Income Taxes

Our  effective  income  tax  rate  was  15.6%  and  21.2%  of  income  before  income  taxes  in  2022  and  2021,  respectively.  See  Note  13,  Income Taxes,  in  our
consolidated financial statements for a reconciliation of the United States federal statutory rate to our effective tax rate. Our effective tax rate could vary from
year to year depending on, among other factors, tax law changes, the geographic and business mix and taxable earnings and losses. We consider these factors
and others, including our history of generating taxable earnings, in assessing our ability to realize deferred tax assets.

Our effective tax rate could vary from year to year depending on, among other factors, tax law changes, the geographic and business mix and taxable earnings
and losses. We consider these factors and others, including our history of generating taxable earnings, in assessing our ability to realize deferred tax assets. We
estimate our worldwide effective income tax rate for 2023 to be approximately 20.7%, estimated based on existing tax laws.

At December 31, 2022, the Company had $9.7 million of valuation allowance against the remaining $195.2 million of gross deferred tax assets recorded at
December 31, 2022. Our deferred tax asset valuation allowance decreased by $0.1 million in 2022, remaining substantially unchanged in 2021. This valuation
allowance relates to deferred tax assets for which the Company does not believe it has satisfied the more likely than not threshold for realization.

At  December  31,  2022,  we  had  net  operating  loss  carryforwards  of  $79.5  million  for  federal  income  tax  purposes,  $75.5  million  for  foreign  income  tax
purposes and $37.9 million for state income tax purposes to offset future taxable income. The federal net operating loss carryforwards increased during 2022
due to the acquisition of SIA. Of the total federal net operating loss carryforwards, $60.9 million expire through 2037 and $18.6 million have an indefinite
carryforward period. Regarding the foreign net operating loss carryforwards, $16.4 million have an indefinite carryforward  period.  The  state  net  operating
loss carryforwards expire in 2036.

As of December 31, 2022, the Company has not provided deferred income taxes on unrepatriated earnings from foreign subsidiaries as they are deemed to be
indefinitely reinvested unless there is a manner under which to remit the earnings with no material tax cost. Such taxes would primarily be attributable to
foreign withholding taxes and local income taxes when such earnings are distributed.

GEOGRAPHIC PRODUCT REVENUES AND OPERATIONS

The  Company  attributes  revenues  to  geographic  areas  based  on  the  location  of  the  customer.  Total  revenue  by  major  geographic  area  consisted  of  the
following:

Dollars in thousands
United States
Europe
Asia Pacific
Rest of World
Total Revenues

Years Ended December 31,

2022
1,126,810  $
170,903 
176,477 
83,476 
1,557,666  $

2021
1,089,526 
191,327 
182,034 
79,561 
1,542,448 

$

$

The  Company  generates  significant  revenues  outside  the  U.S.,  a  portion  of  which  are  U.S.  dollar-denominated  transactions  conducted  with  customers  that
generate  revenue  in  currencies  other  than  the  U.S.  dollar.  As  a  result,  currency  fluctuations  between  the  U.S.  dollar  and  the  currencies  in  which  those
customers  do  business  could  have  an  impact  on  the  demand  for  the  Company's  products  in  foreign  countries.  Local  economic  conditions,  regulatory
compliance or political considerations, the effectiveness of our sales representatives and distributors, local competition and changes in local medical practice
all may combine to affect our sales into markets outside the U.S.

Domestic revenues increased by $37.3 million for the year ended December 31, 2022 compared to the same period last year. These increases are inclusive of
$4.4 million related to the divestiture of the TWC business. European sales decreased by $20.4 million for the year ended December 31, 2022 compared to the
same period last year. Sales to customers in Asia Pacific decreased by $5.6 million for the year ended December 31, 2022 compared to the same period last
year.  The  Rest  of  the  World  for  the  year  ended  December  31,  2022  increased  by  $3.9  million  compared  to  the  same  period  last  year.  The  international
revenues were impacted by a $37.9 million unfavorable foreign exchange impact as well as $5.8 million related to the divestiture of the TWC business.

40

 
LIQUIDITY AND CAPITAL RESOURCES

Working Capital

At December 31, 2022 and December 31, 2021, working capital was $840.6 million and $813.7 million, respectively. Working capital consists of total current
assets less total current liabilities as presented in the consolidated balance sheets.

Cash and Marketable Securities

The Company had cash and cash equivalents totaling approximately $456.7 million and $513.4 million at December 31, 2022 and 2021, respectively, which
are valued based on Level 1 measurements in the fair value hierarchy. At December 31, 2022, our non-U.S. subsidiaries held approximately $229.8 million of
cash  and  cash  equivalents  that  are  available  for  use  outside  the  U.S.  The  Company  asserts  that  it  has  the  ability  and  intends  to  indefinitely  reinvest  the
undistributed earnings from its foreign operations unless there is no material tax cost to remit the earnings into the U.S.

Cash Flows

Dollars in thousands
Net cash provided by operating activities
Net cash used in investing activities
Net cash used (provided) by financing activities
Effect of exchange rate fluctuations on cash
Net increase (decrease) in cash and cash equivalents

Cash Flows Provided by Operating Activities

Year Ended December 31,

2022

2021

$

$

264,469  $
(58,580)
(251,953)
(10,723)
(56,787) $

312,427 
(161,443)
(98,226)
(9,476)
43,282 

Operating cash flows for the year ended December 31, 2022 decreased by $48.0 million compared to the same period in 2021. Net income after removing the
impact  of  the  gain  on  sale  of  businesses  and  non-cash  adjustments  increased  for  the  year  ended  December  31,  2022,  by  approximately  $9.6  million  as
compared to 2021 primarily due to earnings from higher revenues. The changes in assets and liabilities, net of business acquisitions, decreased cash flows by
$39.4 million in 2022 as compared to the increase in cash flows of $18.2 million for the same period in 2021. The change in 2022 is mainly attributable to
increases in inventory and accounts receivable. The increase in inventory is due to a build up of safety stock due to supply chain challenges. The increase in
accounts receivable is due to increased sales as well as a decrease in days sales outstanding.

Operating cash flows for the year ended December 31, 2021 increased by $108.6 million compared to the same period in 2020. Net income after removing the
impact  of  the  gain  on  sale  of  business  and  non-cash  adjustments  increased  for  the  year  ended  December  31,  2021,  by  approximately  $49.1  million  as
compared  to  the  same  period  in  2020  primarily  due  to  the  continuing  revenue  recovery  in  the  current  year  as  compared  to  the  height  of  the  COVID-19
pandemic in the prior year. The changes in assets and liabilities, net of business acquisitions, increased cash flows from operating activities in the current year
by  $18.2  million  compared  to  the  decrease  of  $41.3  million  for  the  same  period  in  2020.  The  improvement  in  2021  working  capital  is  attributable  to  a
decrease in inventory of $5.4 million due to investments in building safety stock made in the prior year where inventory increased by $48.3 million as well as
improved sales in 2021.

Cash Flows Used in Investing Activities

During the year ended December 31, 2022, we paid $42.3 million for capital expenditures to support operations improvement initiatives at a number of our
manufacturing facilities and other information technology investments, $51.5 million to acquire SIA, as well as the $4.7 million payment related to the final
developmental milestone for Rebound Therapeutics Corporation. This was partially offset by the net proceeds from the sale of the TWC business of $24.0
million.  The  proceeds  from  the  sale  of  the  TWC  business  of  $27.8  million  is  presented  net  of  cash  transferred  of  $3.5  million  and  other  transaction  fees.
Additionally, the Company also received $4.9 million proceeds on cross-currency swaps designated as net investment hedge.

During the year ended December 31, 2021, we paid a net cash amount of $303.9 million in relation to the acquisition of ACell and received net proceeds of
$190.5  million  for  the  sale  of  the  Extremity  Orthopedics  business.  The  Company  also  paid  for  $48.0  million  capital  expenditures  to  support  operations
improvement initiatives at a number of our manufacturing facilities and other information technology investments.

41

 
Cash Flows (Used in) Provided by Financing Activities

Uses of cash from financing activities for the year ended December 31, 2022 primarily related to the purchase of treasury stock of $125.0 million under the
2022 accelerated share repurchase agreement that was completed in the first quarter of 2022. In addition, the Company had $24.6 million in cash taxes paid in
net equity settlements as a result of the departure of the former chief executive officer of the Company. The Company also had repayments of $148.6 million
under our Senior Credit Facility and Securitization Facility offset by $40.8 million borrowings under our Senior Credit Facility and Securitization Facility.
The Company also had $5.5 million proceeds from the exercise of stock options. In this Annual Report on Form 10-K, we refer to the sixth amendment and
restatement  of  our  Senior  Credit  Facility  with  a  syndicate  of  lending  banks  with  Bank  of  America,  N.A.,  as  Administrative  Agent  as  the  "Senior  Credit
Facility."

Uses of cash from financing activities for the year ended December 31, 2021 were repayments of $125.5 million on the revolving portion of our Senior Credit
Facility and Securitization Facility. In addition, the Company had $4.8 million in cash taxes paid in net equity settlements. These uses were offset by $6.8
million proceeds from the exercise of stock options and $25.5 million borrowings under our Senior Credit Facility and Securitization Facility.

Amended and Restated Senior Credit Agreement, Convertible Senior Notes, Securitization and Related Hedging Activities

See Note 5, Debt, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for a discussion of our Amended
and Restated Senior Credit Agreement, the 2025 Notes and Securitization Facility and Note 6, Derivative Instruments to the Notes to Consolidated Financial
Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for discussion of our hedging activities. We are forecasting that sales and earnings for the
next twelve months will be sufficient to remain in compliance with our financial covenants under the terms of the February 2020 Amendment and July 2020
Amendment to the Senior Credit Facility.

Share Repurchase Plan

On  January  12,  2022,  the  Company  entered  into  a  $125.0  million  accelerated  share  repurchase  ("2022  ASR")  and  received  1.48  million  shares  of  the
Company common stock at inception of the 2022 ASR, which represented approximately 80% of the expected total shares under the 2022 ASR. On March
24, 2022, the early exercise provision was exercised by 2022 ASR counterparty. Upon settlement on March 24, 2022, the Company received an additional
0.46 million shares determined using the volume-weighted average price of the Company's common stock during the term of the 2022 ASR.

On April 26, 2022, the Board of Directors authorized the Company to repurchase up to $225.0 million of the Company’s common stock. The program allows
the  Company  to  repurchase  its  shares  opportunistically  from  time  to  time.  The  repurchase  authorization  expires  in  December  2024.  This  stock  repurchase
authorization replaces the previous $225 million stock repurchase authorization, of which $100 million remained authorized at the time of its replacement,
and which was otherwise set to expire on December 31, 2022. Purchases may be affected through one or more open market transactions, privately negotiated
transactions, transactions structured through investment banking institutions, or a combination of the foregoing.

On January 26, 2023, the Company entered into a $150 million accelerated share repurchase agreement ("2023 ASR") and received 2.1 million shares of the
Company  common  stock  at  inception  of  the  2023  ASR,  which  represented  approximately  80%  of  the  expected  total  shares  of  under  the  2023  SAR.  The
remaining repurchase transactions are expected to be completed in the first half of 2023.

For the year ended December 31, 2021, there were no repurchases of the Company’s common stock as part of the shar e repurchase authorization.

See Note 8, Treasury Stock, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for further details.

Dividend Policy

We have not paid any cash dividends on our common stock since our formation. Our Senior Credit Facility limits the amount of dividends that we may pay.
Any future determinations to pay cash dividends on our common stock will be at the discretion of the Board and will depend upon our financial condition,
results of operations, cash flows and other factors deemed relevant by the Board.

Capital Resources

We believe that our cash and available borrowings under the Senior Credit Facility are sufficient to finance our operations and capital expenditures over the
next twelve months. Our future capital requirements will depend on many factors, including the growth of our business, the timing and introduction of new
products and investments, strategic plans and acquisitions, among others. Additional sources of liquidity available to us include short term borrowings and the
issuance of long term debt and equity securities.

42

Off-Balance Sheet Arrangements

We do not have any off–balance sheet financing arrangements during the year-ended December 31, 2022 that have or are reasonably likely to have, a current
or future effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital
resources that are material to our interests.

Contractual Obligations and Commitments

We will continue to have cash requirements to support seasonal working capital needs and capital expenditures, to pay interest, to service debt, and to fund
acquisitions. As part of our ongoing operations, we enter into contractual arrangements that obligate us to make future cash payments.

Our primary obligations include principal and interest payments on revolving portion and Term Loan component of the Senior Credit Facility, Securitization
Facility and Convertible Securities. See Note 5, Debt, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-
K) for details. The Company also leases some of our manufacturing facilities and office buildings which have future minimum lease payments associated. See
Note 11, Leases and Related Party Leases, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for a
schedule  of  our  future  minimum  lease  payments.  Amounts  related  to  the  Company's  other  obligations,  including  employment  agreements  and  purchase
obligations were not material.

The Company has contingent consideration obligations related to prior and current year acquisitions and future pension contribution obligations. See Note 10,
Retirement Benefit Plans, and Note 15, Commitments and Contingencies to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual
Report on Form 10-K) for details. The associated obligations are not fixed. The Company also has a liability for uncertain tax benefits including interest and
penalties. See Note 12, Income Taxes to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for details.
The Company cannot make a reliable estimate of the period in which the uncertain tax benefits may be realized.

Employee Termination Benefits

The  Company  incurred  employee  termination  costs  on  restructuring  activities  associated  with  a  closure  of  a  manufacturing  facility  located  in  France,
outsourcing plans for select transactional back office activities, and executive reorganization in the consolidated statement of operations for the year ended
December 31, 2022. In 2021, the Company incurred employee termination costs on restructuring activities associated with the closure of the manufacturing
facility  in  France.  Restructuring  costs  were  included  in  accrued expenses and other current liabilities in  the  consolidated  balance  sheet  for  the  year  ended
December 31, 2022 and 2021. See Note 2, Summary of Significant Accounting Policies, of the Notes to Consolidated Financial Statements (Part IV, Item 15 of
this Annual Report on Form 10-K) for further details.

CRITICAL ACCOUNTING POLICIES AND THE USE OF ESTIMATES

Our discussion and analysis of financial conditions and results of operations is based upon our consolidated financial statements, which have been prepared in
accordance with accounting principles generally accepted in the United States of America ("GAAP"). The preparation of these financial statements requires
us  to  make  estimates  and  assumptions  that  affect  the  reported  amounts  of  assets  and  liabilities,  the  disclosure  of  contingent  liabilities,  and  the  reported
amounts of revenues and expenses. Significant estimates affecting amounts reported or disclosed in the consolidated financial statements include allowances
for doubtful accounts receivable and sales returns and allowances, net realizable value of inventories, valuation of intangible assets including amortization
periods for acquired intangible assets, discount rates and estimated projected cash flows used to value and test impairments of long-lived assets and goodwill,
estimates of projected cash flows and depreciation and amortization periods for long-lived assets, computation of taxes, valuation allowances recorded against
deferred tax assets, the valuation of stock-based compensation, valuation of derivative instruments, valuation of contingent liabilities, the fair value of debt
instruments and loss contingencies. These estimates are based on historical experience and on various other assumptions that are believed to be reasonable
under the current circumstances.

As we continue to navigate the COVID-19 pandemic and recent variants of the virus, as well as the adverse impacts to global economic conditions, supply
chain and our operations, there may be impact to future estimates including, but not limited to, inventory valuations, fair value measurements, goodwill and
long-lived  asset  impairments,  the  effectiveness  of  the  Company’s  hedging  instruments,  deferred  tax  valuation  allowances,  and  allowances  for  doubtful
accounts receivable.

We believe that the following accounting policies, which form the basis for developing these estimates, are those that are most critical to the presentation of
our consolidated financial statements and require the more difficult subjective and complex judgments, often because of the need to make estimates about the
effect of matters that are inherently uncertain. Because of this uncertainty, actual results could differ from these estimates.

43

Inventories

Inventories, consisting of purchased materials, direct labor and manufacturing overhead, are stated at the lower of cost (determined by the first-in, first-out
method) or net realizable value. At each balance sheet date, we evaluate ending inventories for excess quantities, obsolescence or shelf-life expiration. Our
evaluation  includes  an  analysis  of  historical  sales  levels  by  product,  projections  of  future  demand  by  product,  the  risk  of  technological  or  competitive
obsolescence for our products, general market conditions, a review of the shelf-life expiration dates for our products, and the feasibility of reworking or using
excess or obsolete products or components in the production or assembly of other products that are not obsolete or for which we do not have excess quantities
in  inventory.  To  the  extent  that  we  determine  there  are  excess  or  obsolete  quantities  or  quantities  with  a  shelf  life  that  is  too  near  its  expiration  for  us  to
reasonably expect that we can sell those products prior to their expiration, we adjust their carrying value to estimated net realizable value. If future demand or
market  conditions  are  lower  than  our  projections,  or  if  we  are  unable  to  rework  excess  or  obsolete  quantities  into  other  products,  we  may  record  further
adjustments to the carrying value of inventory through a charge to cost of product revenues in the period the revision is made. As of December 31, 2022, our
reserve for inventory obsolesce is 6% of total inventory on our consolidated balance sheets.

The  Company  capitalizes  inventory  costs  associated  with  certain  products  prior  to  regulatory  approval,  based  on  management's  judgment  of  probable
economic benefit. The Company could be required to expense previously capitalized costs related to pre-approval inventory upon a change in such judgment,
due to, among other potential factors, a denial or delay of approval by necessary regulatory bodies or a decision by management to discontinue the related
development program.

Acquisitions

Results of operations of acquired companies are included in the Company’s results of operations as of the respective acquisition dates. The Company accounts
for  the  acquisition  of  a  business  in  accordance  with  ASC  Topic  805,  Business Combinations  ("ASC  Topic  805").  Amounts  paid  to  acquire  a  business  are
allocated to the assets acquired and liabilities assumed based on the fair values at the date of acquisition. Any excess of the purchase price over the fair value
of the net assets acquired in recorded as goodwill. Transaction costs and costs to restructure the acquired company are expensed as incurred.

Contingent  consideration  is  recorded  at  fair  value  as  measured  on  the  date  of  acquisition.  The  value  recorded  is  based  on  estimates  of  future  financial
projections  under  various  potential  scenarios  using  either  a  Monte  Carlo  simulation  or  the  probability-weighted  income  approach  derived  from  revenue
estimates and probability assessment with respect to the likelihood of achieving contingent obligations. Contingent payments related to acquisitions consist of
development, regulatory, and commercial milestone payments, in addition to sales-based payments, and are valued using discounted cash flow techniques.
Each quarter until such contingent amounts are earned, the fair value of the liability is remeasured at each reporting period and adjusted as a component of
operating  expenses  based  on  changes  to  the  underlying  assumptions.  The  change  in  the  fair  value  of  sales-based  payments  is  based  upon  future  revenue
estimates and increases or decreases as revenue estimates or expectation of timing of payment charges. The estimates used to determine the fair value of the
contingent consideration liability are subject to significant judgment and actual results are likely to differ from the amounts originally recorded.

The Company determines the fair value of acquired intangible assets based on detailed valuations that use certain information and assumptions provided by
management. The Company allocates any excess purchase price over the fair value of the net tangible and intangible assets acquired to goodwill. Determining
the  fair  value  of  these  intangible  assets,  acquired  as  part  of  a  business  combination  requires  the  Company  to  make  significant  estimates.  These  estimates
include  the  amount  and  timing  of  projected  future  cash  flows,  the  discount  rate  used  to  discount  those  cash  flows  to  present  value,  the  assessment  of  the
asset’s life cycle, and the consideration of legal, technical, regulatory, economic, and competitive risks. The fair value assigned to other intangible assets is
determined by estimating the future cash flows of each project or technology and discounting the net cash flows back to their present values. The discount rate
used is determined at the time of measurement in accordance with accepted valuation methodologies.

In  our  most  recent  acquisition  of  SIA,  the  key  areas  of  judgement  relating  to  the  valuation  of  the  acquired  definite-lived  developed  technology  intangible
assets were the net revenue growth rates, cost of sales, selling and marketing costs, discounts rates, and asset useful life. The key areas of judgement relating
to the valuation of the contingent consideration are the inputs to the Monte-Carlo model including revenue-adjusted discount rate, counterpart discount rate,
revenue volatility and forecasted revenue, earnings before income taxes and fixed costs. These assumptions were developed with the assistance of a third-
party valuation expert.

44

Acquired IPR&D is recognized at fair value and initially characterized as an indefinite-lived intangible asset, irrespective of whether the acquired IPR&D has
an alternative future use. The Company uses the income approach to determine the fair value of developed technology and IPR&D acquired in a business
combination.  This  approach  determines  fair  value  by  estimating  the  after-tax  cash  flows  attributable  to  the  respective  asset  over  its  useful  life  and  then
discounting these after-tax cash flows back to a present value. Some of the more significant assumptions inherent in the development of those asset valuations
include  the  estimated  net  cash  flows  for  each  year  for  each  product  including  net  revenues,  cost  of  sales,  R&D  costs,  selling  and  marketing  costs,  the
appropriate  discount  rate  to  select  in  order  to  measure  the  risk  inherent  in  each  future  cash  flow  stream,  the  assessment  of  each  asset’s  life  cycle,  and
competitive  trends  impacting  the  asset  and  each  cash  flow  stream.  The  Company  also  uses  the  income  approach,  as  described  above,  to  determine  the
estimated fair value of certain other identifiable intangible assets including customer relationships, trade names and business licenses. Customer relationships
represent  established  relationships  with  customers,  which  provide  a  ready  channel  for  the  sale  of  additional  products  and  services.  Trade  names  represent
acquired company and product names.

IPR&D acquired in a business combination is capitalized as an indefinite-lived intangible asset. Development costs incurred after the acquisition are expensed
as incurred. Upon receipt of regulatory approval, the indefinite-lived intangible asset is then accounted for as a finite-lived intangible asset and amortized on a
straight-line basis or accelerated basis, as appropriate, over its estimated useful life. If the research and development project is subsequently abandoned, the
indefinite-lived intangible asset is charged to expense. IPR&D acquired outside of a business combination is expensed immediately.

Due to the uncertainty associated with research and development projects, there is risk that actual results will differ materially from the original cash flow
projections  and  that  the  research  and  development  project  will  result  in  a  successful  commercial  product.  The  risks  associated  with  achieving
commercialization include, but are not limited to, delay or failure to obtain regulatory approvals to conduct clinical trials, delay or failure to obtain required
market clearances, delays or issues with patent issuance, or validity and litigation.

If the acquired net assets do not constitute a business under the acquisition method of accounting, the transaction is accounted for as an asset acquisition and
no  goodwill  is  recognized.  In  an  asset  acquisition,  the  amount  allocated  to  acquired  IPR&D  with  no  alternative  future  use  is  charged  to  expense  at  the
acquisition  date.  Payments  that  would  be  recognized  as  contingent  consideration  in  a  business  combination  are  expensed  when  probable  in  an  asset
acquisition. Refer to Note 4, Acquisitions and Divestitures to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on Form
10-K) for details.

Valuation of Goodwill

The excess of the cost over the fair value of net assets of acquired businesses is recorded as goodwill. Goodwill is not subject to amortization but is reviewed
for  impairment  at  the  reporting  unit  level  annually,  or  more  frequently  if  impairment  indicators  arise.  The  Company's  assessment  of  the  recoverability  of
goodwill  is  based  upon  a  comparison  of  the  carrying  value  of  goodwill  with  its  estimated  fair  value.  Key  assumptions  used  to  estimate  the  fair  value  of
goodwill include the Company's discounts rate and forecasted operating results. The Company had goodwill on the balance sheet of $1 billion as of December
31, 2022. The Company reviews goodwill for impairment in the third quarter every year in accordance with ASC Topic 350, Intangibles - Goodwill and Other
("ASC  Topic  350"),  and  whenever  events  or  changes  in  circumstances  indicate  the  carrying  value  of  goodwill  may  not  be  recoverable.  Refer  to  Note  7,
Goodwill  and  Other  Intangibles,  to  the  Notes  to  Consolidated  Financial  Statements  (Part  IV,  Item  15  of  this  Annual  Report  on  Form  10-K)  for  more
information.

Valuation of Identifiable Intangible Assets

The Company tests intangible assets with indefinite lives for impairment annually in the third quarter in accordance with ASC Topic 350. Additionally, the
Company may perform interim tests if an event occurs or circumstances change that could potentially reduce the fair value of a indefinite lived intangible
asset  below  its  carrying  amount.  The  Company  tests  for  impairment  by  either  performing  a  qualitative  evaluation  or  a  quantitative  test.  The  qualitative
evaluation is an assessment of factors, including specific operating results as well as industry, market and general economic conditions, to determine whether
it  is  more  likely  than  not  that  the  fair  values  of  the  intangible  asset  is  less  than  its  carrying  amount.  The  Company  may  elect  to  bypass  this  qualitative
evaluation and perform a quantitative test. There were no changes to identifiable intangible assets as a result of the Company's assessments.

Product  rights  and  other  definite-lived  intangible  assets  are  tested  periodically  for  impairment  in  accordance  with  ASC  Topic  360,  Property,  Plant  and
Equipment, ("ASC Topic 360") when events or changes in circumstances indicate that an asset's carrying value may not be recoverable. The impairment test
involves comparing the carrying amount of the asset or asset group to the forecasted undiscounted future cash flows. In the event the carrying value of the
asset exceeds the undiscounted future cash flows, the carrying value is considered not recoverable and impairment exists. An impairment loss is measured as
the excess of the asset's carrying value over its fair value, calculated using discounted future cash flows. The computed impairment loss is recognized in the
period that the impairment occurs.

45

As of December 31, 2022, the Company has $1.1 billion of identifiable intangible assets, net on the balance sheets.

Income Taxes

Since we conduct operations on a global basis, our effective tax rate has and will depend upon the geographic distribution of our pre-tax earnings among
locations with varying tax rates. Changes in the tax rates of the various jurisdictions in which we operate affect our profits. In addition, we maintain a reserve
for  uncertain  tax  benefits,  changes  to  which  could  impact  our  effective  tax  rate  in  the  period  such  changes  are  made.  The  effective  tax  rate  can  also  be
impacted by changes in valuation allowances of deferred tax assets, and tax law changes.

Our provision for income taxes may change period-to-period based on specific events, such as the settlement of income tax audits and changes in tax laws, as
well  as  general  factors,  including  the  geographic  mix  of  income  before  taxes,  state  and  local  taxes  and  the  effects  of  the  Company's  global  income  tax
strategies. We maintain strategic management and operational activities in overseas subsidiaries. See Note 12, Income Taxes, to the Notes to Consolidated
Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K), in our consolidated financial statements for disclosures related to foreign and
domestic pretax income, foreign and domestic income tax expense (benefit) and the effect foreign taxes have on our overall effective tax rate.

We recognize a tax benefit from an uncertain tax position only if it is more likely than not to be sustained upon examination based on the technical merits of
the position. The amount of the accrual for which an exposure exists is measured by determining the amount that has a greater than 50 percent likelihood of
being realized upon ultimate settlement of the position. Components of the reserve are classified as a long-term liability in the consolidated balance sheets.
We record interest and penalties accrued in relation to uncertain tax benefits as a component of income tax expense.

We  believe  that  we  have  identified  all  reasonably  identifiable  exposures  and  that  the  reserve  we  have  established  for  identifiable  exposures  is  appropriate
under  the  circumstances;  however,  it  is  possible  that  additional  exposures  exist  and  that  exposures  will  be  settled  at  amounts  different  from  the  amounts
reserved.  It  is  also  possible  that  changes  in  facts  and  circumstances  could  cause  us  to  either  materially  increase  or  reduce  the  carrying  amount  of  our  tax
reserves.

Our deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting
purposes and their basis for income tax purposes, and the temporary differences created by the tax effects of capital loss, net operating loss and tax credit
carryforwards. We record valuation allowances when it is more likely than not that some portion or all of the deferred tax assets will not be realized. We could
recognize  no  benefit  from  our  deferred  tax  assets  or  we  could  recognize  some  or  all  of  the  future  benefit  depending  on  the  amount  and  timing  of  taxable
income we generate in the future.

We intend to indefinitely reinvest substantially all of our foreign earnings in our foreign subsidiaries unless there is a tax–free manner under which to remit
the earnings. The current analysis indicates that we have sufficient U.S. liquidity, including borrowing capacity, to fund foreseeable U.S. cash needs without
requiring the repatriation of foreign cash. One time or unusual items that may impact our ability or intent to keep the foreign earnings and cash indefinitely
reinvested include significant U.S. acquisitions, loans from a foreign subsidiary, and changes in tax laws.

As of December 31, 2022, the Company has not provided deferred income taxes on unrepatriated earnings from foreign subsidiaries as they are deemed to be
indefinitely reinvested unless there is a manner under which to remit the earnings with no material tax cost. Such taxes would primarily be attributable to
foreign withholding taxes and local income taxes when such earnings are distributed.

Recently Issued and Adopted Accounting Standards

Refer to Note 2, Summary of Significant Accounting Policies, to the Notes to Consolidated Financial Statements (Part IV, Item 15 of this Annual Report on
Form 10-K), to the consolidated financial statements for recently adopted accounting pronouncements.

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We  are  exposed  to  various  market  risks,  including  changes  in  foreign  currency  exchange  rates  and  interest  rates  that  could  adversely  affect  our  results  of
operations and financial condition. To manage the volatility relating to these typical business exposures, we may enter into various derivative transactions
when appropriate. We do not hold or issue derivative instruments for trading or other speculative purposes.

46

Foreign Currency Exchange and Other Rate Risks

We operate on a global basis and are exposed to the risk that changes in foreign currency exchange rates could adversely affect our financial condition, results
of  operations  and  cash  flows.  We  are  primarily  exposed  to  foreign  currency  exchange  rate  risk  with  respect  to  transactions  and  net  assets  denominated  in
Euros, British pounds, Swiss francs, Canadian dollars, Japanese yen, Mexican pesos, Brazilian reais, Australian dollars and Chinese yuan. We manage the
foreign  currency  exposure  centrally,  on  a  combined  basis,  which  allows  us  to  net  exposures  and  to  take  advantage  of  any  natural  offsets.  To  mitigate  the
impact  of  currency  fluctuations  on  transactions  denominated  in  nonfunctional  currencies,  we  periodically  enter  into  derivative  financial  instruments  in  the
form  of  foreign  currency  exchange  forward  contracts  with  major  financial  institutions.  We  temporarily  record  realized  and  unrealized  gains  and  losses  on
these contracts that qualify as cash flow hedges in other comprehensive income, and then recognize them in other income or expense when the hedged item
affects net earnings.

From time to time, we enter into foreign currency forward exchange contracts to manage currency exposures for transactions denominated in a currency other
than an entity’s functional currency. As a result, the impact of foreign currency gains/losses recognized in earnings are partially offset by gains/losses on the
related  foreign  currency  forward  exchange  contracts  in  the  same  reporting  period.  Refer  to  Note  6,  Derivative Instruments,  to  the  Notes  to  Consolidated
Financial Statements (Part IV, Item 15 of this Annual Report on Form 10-K) for additional information.

We maintain written policies and procedures governing our risk management activities. With respect to derivatives, changes in hedged items are generally
expected to be completely offset by changes in the fair value of hedge instruments. Consequently, foreign currency exchange contracts would not subject us to
material risk due to exchange rate movements, because gains and losses on these contracts offset gains and losses on the assets, liabilities or transactions being
hedged.

The results of operations discussed herein have not been materially affected by inflation.

Interest Rate Risk

Cash  and  Cash  Equivalents  -  We  are  exposed  to  the  risk  of  interest  rate  fluctuations  on  the  interest  income  earned  on  our  cash  and  cash  equivalents.  A
hypothetical 100 basis points movement in interest rates applicable to our cash and cash equivalents outstanding at December 31, 2022 would increase interest
income  by  approximately  $5.1  million  on  an  annual  basis.  No  significant  decrease  in  interest  income  would  be  expected  as  our  cash  balances  are  earning
interest  at  rates  of  approximately  one  basis  points.  We  are  subject  to  foreign  currency  exchange  risk  with  respect  to  cash  balances  maintained  in  foreign
currencies.

Debt  -  Our  interest  rate  risk  relates  primarily  to  U.S.  dollar  LIBOR-indexed  borrowings.  We  use  interest  rate  swap  derivative  instruments  to  manage  our
earnings  and  cash  flow  exposure  to  changes  in  interest  rates.  These  interest  rate  swaps  fix  the  interest  rate  on  a  portion  of  our  expected  LIBOR-indexed
floating-rate borrowings. The Company held the following interest rate swaps as of December 31, 2022 (dollar amounts in thousands):

Hedged Item

Notional Amount

Designation Date

Effective Date

Termination Date

Fixed Interest Rate

Estimated Fair Value

Assets (Liabilities)

1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan
1-month USD LIBOR
Loan

75,000 

100,000 

100,000 

575,000 

125,000 

1,475,000 

$

150,000 

December 13, 2017

July 1, 2019

June 30, 2024

200,000 

December 13, 2017

January 1, 2018

December 31, 2024

75,000 

October 10, 2018

July 1, 2020

June 30, 2025

75,000 

October 10, 2018

October 10, 2018

July 1, 2020

July 1, 2020

June 30, 2025

June 30, 2025

December 18, 2018

December 30, 2022

December 31, 2027

December 18, 2018

December 30, 2022

December 31, 2027

December 15, 2020

July 31, 2025

December 31, 2027

December 15, 2020

July 1, 2025

December 31, 2027

47

2.423 %

2.313 %

3.220 %

3.199 %

3.209 %

2.885 %

2.867 %

1.415 %

1.404 %

$

5,012 

8,380 

1,831 

1,905 

1,970 

4,252 

4,153 

23,742 

5,467 

56,712 

These interest rate swaps were designated as cash flow hedges as of December 31, 2022. The total notional amounts related to the Company’s interest rate
swaps were $1.5 billion and with $775.0 million effective as of December 31, 2022. Based on our outstanding borrowings at December 31, 2022, a 100 basis
points change in interest rates would have impacted interest expense on the unhedged portion of the debt by $1.1 million on an annualized basis.

ITEM 8.

FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

Financial  statements  and  the  financial  statement  schedule  specified  by  this  Item,  together  with  the  report  thereon  of  PricewaterhouseCoopers  LLP,  are
presented following Item 15. Exhibits and Financial Statement Schedule of this Annual Report on Form 10-K.

ITEM 9.

CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURES

Not applicable.

48

ITEM 9A.

CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

We maintain disclosure controls and procedures that are designed to provide reasonable assurance that information required to be disclosed in our Exchange
Act reports is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms
and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as
appropriate, to allow for timely decisions regarding required disclosure. Disclosure controls and procedures, no matter how well designed and operated, can
provide only reasonable assurance of achieving the desired control objectives, and management is required to apply its judgment in evaluating the cost-benefit
relationship  of  possible  controls  and  procedures.  Management  has  designed  our  disclosure  controls  and  procedures  to  provide  reasonable  assurance  of
achieving the desired control objectives.

As  required  by  Exchange  Act  Rule  13a-15(b),  we  have  carried  out  an  evaluation,  under  the  supervision  and  with  the  participation  of  our  management,
including  our  principal  executive  officer  and  principal  financial  officer,  of  the  effectiveness  of  the  design  and  operation  of  our  disclosure  controls  and
procedures as of December 31, 2022. Based upon this evaluation, our principal executive officer and principal financial officer concluded that our disclosure
controls and procedures were effective as of December 31, 2022 to provide such reasonable assurance.

Management’s Report on Internal Control Over Financial Reporting

Management  is  responsible  for  establishing  and  maintaining  adequate  internal  control  over  financial  reporting  as  defined  in  Rules  13a-15(f)  under  the
Securities Exchange Act of 1934, as amended. Internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of
financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles in the United
States  of  America  (“GAAP”).  We  recognize  that  because  of  its  inherent  limitations,  internal  control  over  financial  reporting  may  not  prevent  or  detect
misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of
changes in conditions or that the degree of compliance with the policies and procedures may deteriorate.

To  evaluate  the  effectiveness  of  our  internal  control  over  financial  reporting,  management  used  the  criteria  described  in  Internal  Control  —  Integrated
Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (“COSO”). Based upon this evaluation, management
concluded that our internal control over financial reporting was effective as of December 31, 2022.

The effectiveness of the Company’s internal control over financial reporting as of December 31, 2022 has been audited by PricewaterhouseCoopers LLP, an
independent registered public accounting firm, as stated in their report which appears herein.

Changes in Internal Control Over Financial Reporting

There were no changes in our internal control over financial reporting (as defined in Rule 13a-15(f) under the Exchange Act) that occurred during the quarter
ended December 31, 2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

ITEM 9B.

OTHER INFORMATION

The following disclosure is intended to satisfy any obligation to provide disclosures pursuant to Item 5.03 of Form 8-K.

Effective as of February 21, 2023, based on the recommendation of the Nominating and Corporate Governance Committee of the Board of Directors (the
“Board”)  of  Integra  LifeSciences  Holdings  Corporation  (the  “Company”),  in  connection  with  the  new  Securities  and  Exchange  Commission  rules  and
changes to the Securities Exchange Act of 1934, as amended (the "Exchange Act"), regarding universal proxy cards, certain recent changes to the Delaware
General Corporation Law (the "DGCL"), and a periodic review of corporate governance matters, the Board approved amendments to the Company’s Second
Amended and Restated Bylaws, as amended (the “Third A&R Bylaws”).

The Third A&R Bylaws, among other things:

• Address matters relating to Rule 14a-19 under the Exchange Act (the "Universal Proxy Rules"), including requiring: (a) the stockholder’s nomination
notice to include a representation that it intends to solicit proxies from stockholders representing at least 67% of the voting power of shares entitled
to vote on the election of directors; (b) the stockholder to comply with the Universal Proxy Rules and provide reasonable evidence thereof prior to
the stockholder meeting; and (c) the stockholder to use a proxy card color other than white, which is reserved for the exclusive use of the Board.
(Article 2, Sections 2.03, 2.08, and 2.10)
Enhance the informational and procedural requirements in connection with stockholder proposals and stockholder director nominations, including:
(a) requiring additional information about the stockholder making the director

•

49

nomination or proposal; (b) requiring additional information about the stockholder proposed business and/or director nominee; and (c) providing that
the number of nominees a stockholder may nominate for election at the annual meeting of the stockholders may not exceed the number of directors
to be elected at such annual meeting. (Article 2, Sections 2.03 and 2.10)

• Modify the provisions relating to adjournment procedures, availability of lists of stockholders entitled to vote at stockholder meetings, and electronic

notices, in each case, to reflect amendments to the DGCL. (Article 2, Sections 2.04 and 2.05; Article 4, Section 4.01)
Provide that any proxies received for disqualified or withdrawn Board nominees will be treated as abstentions. (Article 2, Section 2.08)

•
• Add a provision for stockholder actions by written consent that requires the Company to engage an independent inspector of election to perform a

•

review of the validity of the applicable consents and revocations. (Article 2, Section 2.09)
Clarify  the  powers  of  the  chair  of  a  stockholder  meeting,  including  with  respect  to  the  chair’s  ability  to  prescribe  rules  and  regulations  for  the
conduct of the meeting. (Article 2, Section 2.11)

• Add a federal forum provision to designate the federal district courts as the exclusive forum for matters arising under the Securities Act of 1933, as

amended, and the Exchange Act. (Article 8, Section 8.02)

• Make  various  other  updates,  including  ministerial  and  conforming  changes  and  changes  to  clarify  the  Company’s  ability  to  conduct  business  by

means of remote communication.

The  foregoing  description  of  the  Third  A&R  Bylaws  is  qualified  in  its  entirety  by  the  full  text  of  the  Third  A&R  Bylaws  filed  as  Exhibit  3.3  hereto  and
incorporated herein by reference.

ITEM 9C.

DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS

Not applicable.

INCORPORATION BY REFERENCE

PART III

The information called for by Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities relating
to  equity  compensation  plans,  Item  10.  Directors,  Executive  Officers  and  Corporate  Governance,  Item  11.  Executive  Compensation,  Item  12.  Security
Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters, Item 13. Certain Relationships and Related Transactions, and
Director Independence and Item 14. Principal Accountant Fees and Services is incorporated herein by reference to the Company’s definitive proxy statement
for its Annual Meeting of Stockholders scheduled to be held on May 12, 2023, which definitive proxy statement is expected to be filed with the Commission
not later than 120 days after the end of the fiscal year to which this report relates.

ITEM 15.

EXHIBITS AND FINANCIAL STATEMENT SCHEDULE

PART IV

(a) Documents filed as a part of this report:

1. Financial Statements.

The following financial statements and financial statement schedules are filed as a part of this report: 
Report of Independent Registered Public Accounting Firm (PricewaterhouseCoopers LLP, Florham Park, New Jersey, PCAOB ID# 238000)
Consolidated Statements of Operations for the years ended December 31, 2022, 2021 and 2020
Consolidated Statements of Comprehensive Income for the years ended December 31, 2022, 2021 and 2020
Consolidated Balance Sheets as of December 31, 2022 and 2021
Consolidated Statements of Cash Flows for the years ended December 31, 2022, 2021 and 2020
Consolidated Statements of Changes in Stockholders’ Equity for the years ended December 31, 2022, 2021 and 2020
Notes to Consolidated Financial Statements

F-1
F-3
F-4
F-5
F-6
F-7
F-8

50

All other schedules not listed above have been omitted, because they are not applicable or are not required, or because the required information is included in
the consolidated financial statements or notes thereto.

3. Exhibits required to be filed by Item 601 of Regulation S-K.
2.1(a)

Put  Option  Agreement,  dated  September  29,  2020,  between  the  Company  and  certain  of  its  subsidiaries  and  Smith  &  Nephew  USD
Limited, a subsidiary of Smith+Nephew (including the Purchase and Sale Agreement attached as Appendix 1 thereto) (Incorporated by
reference to Exhibit 2.1 to the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2020).

2.1(b)

3.1(a)

3.1(b)

3.1(c)

3.1(d)

3.2

3.3

4.1

4.2

4.3

4.4

10.1(a)

10.1(b)

10.2(a)

10.2(b)

10.3(a)

Agreement  and  Plan  of  Merger  by  among  Integra  LifeSciences  Holdings  Corporation  and  ACell  Inc.  dated  as  of  December  15,  2020
(Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2020)

Amended and Restated Certificate of Incorporation of the Company dated February 16, 1993 (Incorporated by reference to Exhibit 3.1(a)
to the Company’s Annual Report on Form 10-K for the year ended December 31, 2005)

Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Company dated May 22, 1998 (Incorporated by
reference to Exhibit 3.1(b) to the Company’s Annual Report on Form 10-K for the year ended December 31, 1998)

Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Company dated May 17, 1999 (Incorporated by
reference to Exhibit 3.1(c) to the Company’s Annual Report on Form 10-K for the year ended December 31, 2004)

Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Company dated December 21, 2016 (Incorporated
by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K filed on December 22, 2016)

Second Amended and Restated Bylaws of Integra LifeSciences Holdings Corporation, effective as of December 11, 2018 (Incorporated by
reference to Exhibit 3.2 to the Company’s Current Report on Form 8-k filed on December 12, 2018)

Third Amended and Restated Bylaws of Integra LifeSciences Holdings Corporation, effective as of February 21, 2023 +

Indenture,  dated  as  of  February  7,  2020,  by  and  between  Integra  LifeSciences  Holdings  Corporation  and  Citibank,  N.A.,  as  trustee
(including Form of 0.50% Convertible Senior Notes due 2025) (Incorporated by reference to Exhibit 4.1 to the Company’s Current Report
on Form 8-K filed on February 7, 2020).

First Supplemental Indenture, by and between Integra LifeSciences Holdings Corporation and Citibank, N.A., as trustee (Incorporated by
reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K filed on December 9, 2020)

Integra  LifeSciences  Deferred  Compensation  Plan,  effective  as  of  May  16,  2019  (Incorporated  by  reference  to  Exhibit  4.13  to  the
Company's Current Form S-8 Registration Statement filed on May 23, 2019)

Description of Securities+

Lease  Modification  #3  entered  into  as  of  March  2,  2011,  by  and  between  Plainsboro  Associates  and  Integra  LifeSciences  Corporation
(Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on March 3, 2011)

Lease  Modification  #4  entered  into  as  of  April  20,  2017,  by  and  between  Plainsboro  Associates  and  Integra  LifeSciences  Corporation
(Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on April 25, 2017)

Employee Stock Purchase Plan (as amended on May 17, 2004) (Incorporated by reference to Exhibit 4.1 to the Company’s Registration
Statement on Form S-8 (Registration No. 333-127488) filed on August 12, 2005)*

First Amendment to Employee Stock Purchase Plan, dated October 26, 2005 (Incorporated by reference to Exhibit 10.1 to the Company’s
Current Report on Form 8-K filed on November 1, 2005)*

Second  Amended  and  Restated  2003  Equity  Incentive  Plan  effective  May  19,  2010  (Incorporated  by  reference  to  Exhibit  10  to  the
Company’s Current Report on Form 8-K filed May 21, 2010)*

51

10.3(b)

10.3(c)

10.3(d)

10.3(e)

10.3(f)

10.3(g)

10.3(h)

10.3(i)

10.3(j)

10.3(k)

10.3(l)

10.4

10.5

10.6

10.7

10.8

10.9

10.10

10.11(a)

10.11(b)

Amendment  to  the  Second  Amended  and  Restated  2003  Equity  Incentive  Plan  effective  May  17,  2012  (Incorporated  by  reference  to
Exhibit 10.9 to the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2012)*

Amendment to the Second Amended and Restated 2003 Equity Incentive Plan effective January 1, 2013 (Incorporated by reference to
Exhibit 10.4 to the Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2013)*

Third  Amended  and  Restated  2003  Equity  Incentive  Plan  effective  May  22,  2015  (Incorporated  by  reference  to  Exhibit  10.1  to  the
Company’s Current Report on Form 8-K filed on May 29, 2015)*

Fourth  Amended  and  Restated  2003  Equity  Incentive  Plan,  effective  May  23,  2017  (Incorporated  by  reference  to  Exhibit  10.1  to  the
Company’s Current Report on Form 8-K filed on May 25, 2017)*

Amendment to the Integra LifeSciences Holdings Corporation Fourth Amended and Restated 2003 Equity Incentive Plan (Incorporated
by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2020)*

Integra LifeSciences Holdings Corporation Fifth Amended and Restated 2003 Equity Incentive Plan (Incorporated by reference to Exhibit
10.1 to the Company’s Current Report on Form 8-K filed on May 18, 2021)*

Form  of  Integra  LifeSciences  Holdings  Corporation  Fifth  Amended  and  Restated  2003  Equity  Incentive  Plan  Restricted  Stock  Award
Agreement – Directors*+

Form of Integra LifeSciences Holdings Corporation Fifth Amended and Restated 2003 Equity Incentive Plan Restricted Stock Agreement
– Executive Officers*+

Form  of  Integra  LifeSciences  Holdings  Corporation  Fifth  Amended  and  Restated  2003  Equity  Incentive  Plan  Performance  Stock  Unit
Award Agreement*+

Form of Integra LifeSciences Holdings Corporation Fifth Amended and Restated 2003 Equity Incentive Plan Non-Qualified Stock Option
Award Agreement*+

Form  of  Integra  LifeSciences  Holdings  Corporation  Fifth  Amended  and  Restated  2003  Equity  Incentive  Plan  Restricted  Stock  Award
Agreement – OUS*+

Form of Indemnification Agreement, by and between Integra LifeSciences Holdings Corporation and each of its directors and executive
officers (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on July 19, 2022)*

Annual Executive Physical Medical Exam Arrangement (Incorporated by reference to the Exhibit 10.2 to the Company’s Current Report
on Form 8-K filed on July 29, 2013)*

2018 Performance Incentive Compensation Plan, effective January 1, 2018 (Incorporated by reference to Exhibit 10.2 to the Company’s
Current Report on Form 8-K filed on May 25, 2017)*

Integra  LifeSciences  Holdings  Corporation  Change  in  Control  Severance  Program  (Incorporated  by  reference  to  Exhibit  10.1  to  the
Company’s Current Report on Form 8-K filed on December 14, 2022)*

Amended and Restated Management Incentive Compensation Plan, as of January 1, 2008 (Incorporated by reference to Exhibit 10.43(c)
to the Company’s Annual Report on Form 10-K for the year ended December 31, 2007)*

Employment  Agreement,  dated  October  28,  2021,  by  and  between  Integra  LifeSciences  Holdings  Corporation,  Integra  LifeSciences
Corporation and Jan De Witte (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on October
28, 2021)*

Davis Promotion Summary, effective December 1, 2016 (Incorporated by reference to Exhibit 10.2 to the Company’s Current Report on
Form 8-K filed on December 5, 2016)*

Coleman Promotion Summary, effective June 24, 2019 (Incorporated by reference to the Current Report on Form 8-K filed on June 24,
2019)*

Separation  Agreement  and  General  Release,  dated  September  23,  2022,  by  and  between  Glenn  Coleman,  Integra  LifeSciences
Corporation and Integra LifeSciences Holdings Corporation (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report
on Form 8-K filed on September 23, 2022)*

52

10.12

10.13(a)

10.13(b)

10.13(c)

10.13(d)

10.14

10.15(a)

10.15(b)

10.16

10.17

10.18

10.19

Anderson Offer Summary, effective June 24, 2019(Incorporated by reference to the Current Report on Form 8-K filed on June 24, 2019)*

Receivables Financing Agreement, dated as of December 21, 2018, by and among Integra Receivables LLC, Integra LifeSciences Sales
LLC,  as  Servicer,  PNC  Bank,  National  Association,  as  Administrative  Agent,  PNC  Capital  Markets  LLC,  as  Structuring  Agent,  and
certain lenders and group agents that are parties thereto from time to time (Incorporated by reference to Exhibit 10.1 to the Company’s
Current Report on Form 8-K filed on December 28, 2018)

Amendment No. 1 to Receivables Financing Agreement and Reaffirmation of Performance Guaranty, dated as of March 29, 2019, by and
among  Integra  Receivables  LLC,  Integra  LifeSciences  Sales  LLC,  as  Servicer,  PNC  Bank,  National  Associations,  as  Administrative
Agent, Committed Lender and Group Agent, Mizuho Bank, Ltd., as Committed Lender and Group Agent and PNC Capital Markets LLC,
as  Structuring  Agent,  and  certain  lenders  and  group  agents  that  are  parties  thereto  from  time  to  time  (Incorporated  by  reference  to  the
Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2021)

Amendment No. 2 to Receivables Financing Agreement and Reaffirmation of Performance Guaranty, dated as of July 17, 2020, by and
among,  Integra  Receivables  LLC,  Integra  LifeSciences  Sales  LLC,  as  Servicer,  PNC  Bank,  National  Associations,  as  Administrative
Agent, Committed Lender and Group Agent, Mizuho Bank, Ltd., as Committed Lender and Group Agent and PNC Capital Markets LLC,
as  Structuring  Agent,  and  certain  lenders  and  group  agents  that  are  parties  thereto  from  time  to  time  (Incorporated  by  reference  to  the
Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2021)

Amendment No. 3 to Receivables Financing Agreement and Reaffirmation of Performance Guaranty, dated as of May 28, 2021, by and
among,  Integra  Receivables  LLC,  Integra  LifeSciences  Sales  LLC,  as  Servicer,  PNC  Bank,  National  Associations,  as  Administrative
Agent, PNC Capital Markets LLC, as Structuring Agent, Committed Lender and Group Agent, and certain lenders and group agents that
are parties thereto from time to time (Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended
June 30, 2021)

Purchase  and  Sale  Agreement,  dated  as  of  December  21,  2018,  by  and  among  Integra  LifeSciences  Sales  LLC,  Integra  LifeSciences
Corporation and Integra Receivables LLC (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed
on December 28, 2018)

Sixth  Amended  and  Restated  Credit  Agreement,  dated  as  of  February  3,  2020,  among  Integra  LifeSciences  Holdings  Corporation,  the
lenders party thereto, Bank of America, N.A., as Administrative Agent, Swing Line Lender and an L/C Issuer, Citibank N.A., Morgan
Stanley MUFG Loan Partners, LLC and Wells Fargo Bank, N.A., as Co-Syndication Agents, and PNC Bank, N.A., Bank of Nova Scotia,
Bank of the West, BBVA USA, Capital One, National Association, Citizens Bank, N.A., DNB Capital LLC, Santander Bank, N.A., TD
Bank, N.A. and Truist Bank, as Co-Documentation Agents. (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report
on Form 8-K filed on February 3, 2020).

Amendment,  dated  July  14,  2020,  to  that  Sixth  Amended  and  Restated  Credit  Agreement,  among  Integra  LifeSciences  Holdings
Corporation, a syndicate of lending banks, Bank of America, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer, Citibank
N.A., Morgan Stanley MUFG Loan Partners, LLC and Wells Fargo Bank, N.A. as Co-Syndication Agents, and PNC Bank, N.A., Bank of
Nova  Scotia,  Bank  of  the  West,  BBVA  USA,  Capital  One,  National  Association,  Citizens  Bank,  N.A.,  DNB  Capital  LLC,  Santander
Bank, N.A., T.D. Bank, N.A. and Truist Bank, as Co-Documentation Agents (as amended, restated, modified and supplemented from time
to time prior to the date hereof, the “Credit Agreement”) (Incorporated by reference to Exhibit 4.1 to the Company’s Current Report on
Form 8-K filed on July 20, 2020).

Base  Call  Option  Transaction  Confirmation,  dated  as  of  February  4,  2020,  between  Integra  LifeSciences  Holdings  Corporation  and
Citibank, N.A. (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Ratification Agreement, dated as of February 3, 2020, between Integra LifeSciences Holdings Corporation, the Subsidiary Guarantors of
Integra LifeSciences Holdings Corporation and Bank of America, N.A., as Administrative Agent (Incorporated by reference to Exhibit
10.2 to the Company’s Current Report on Form 8-K filed on February 3, 2020)

Base  Call  Option  Transaction  Confirmation,  dated  as  of  February  4,  2020,  between  Integra  LifeSciences  Holdings  Corporation  and
Morgan Stanley & Co. International plc. (Incorporated by reference to Exhibit 10.3 to the Company’s Current Report on Form 8-K filed
on February 7, 2020)

Base Call Option Transaction Confirmation, dated as of February 4, 2020, between Integra LifeSciences Holdings Corporation and Wells
Fargo, National Association. (Incorporated by reference to Exhibit 10.4 to the Company’s Current Report on Form 8-K filed on February
7, 2020)

53

10.20

10.21

10.22

10.23

10.24

10.25

10.27

10.28

10.29

10.30

10.31

10.32

10.33

21.1

23.1

31.1

31.2

32.1

32.2

Base  Warrant  Confirmation,  dated  as  of  February  4,  2020,  between  Integra  LifeSciences  Holdings  Corporation  and  Citibank,  N.A.
(Incorporated by reference to Exhibit 10.5 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Base Warrant Confirmation, dated as of February 4, 2020, between Integra LifeSciences Holdings Corporation and Goldman Sachs & Co.
LLC. (Incorporated by reference to Exhibit 10.6 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Base Warrant Confirmation, dated as of February 4, 2020, between Integra LifeSciences Holdings Corporation and Morgan Stanley & Co.
International plc. (Incorporated by reference to Exhibit 10.7 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Base Warrant Confirmation, dated as of February 4, 2020, between Integra LifeSciences Holdings Corporation and Wells Fargo, National
Association. (Incorporated by reference to Exhibit 10.8 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Additional Call Option Transaction Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and
Citibank, N.A. (Incorporated by reference to Exhibit 10.9 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Additional Call Option Transaction Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and
Goldman Sachs & Co. LLC. (Incorporated by reference to Exhibit 10.10 to the Company’s Current Report on Form 8-K filed on February
7, 2020)

Additional Call Option Transaction Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and
Morgan Stanley & Co. International plc. (Incorporated by reference to Exhibit 10.11 to the Company’s Current Report on Form 8-K filed
on February 7, 2020)

Additional Call Option Transaction Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and
Wells Fargo, National Association. (Incorporated by reference to Exhibit 10.12 to the Company’s Current Report on Form 8-K filed on
February 7, 2020)

Additional Warrant Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and Citibank, N.A.
(Incorporated by reference to Exhibit 10.13 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Additional Warrant Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and Goldman Sachs
& Co. LLC. (Incorporated by reference to Exhibit 10.14 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Additional Warrant Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation and Morgan Stanley
& Co. plc. (Incorporated by reference to Exhibit 10.15 to the Company’s Current Report on Form 8-K filed on February 7, 2020)

Additional  Warrant  Confirmation,  dated  as  of  February  5,  2020,  between  Integra  LifeSciences  Holdings  Corporation  and  Wells  Fargo,
National Association. (Incorporated by reference to Exhibit 10.16 to the Company’s Current Report on Form 8-K filed on February 7,
2020)

Issuer Forward Repurchase Transaction Confirmation, dated as of February 5, 2020, between Integra LifeSciences Holdings Corporation
and  JPMorgan  Chase  Bank,  National  Association,  New  York  Branch.  (Incorporated  by  reference  to  Exhibit  10.17  to  the  Company’s
Current Report on Form 8-K filed on February 7, 2020)

Subsidiaries of the Company+

Consent of PricewaterhouseCoopers LLP+

Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002+

Certification of Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002+

Certification of Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002+

Certification of Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002+

101.INS

XBRL Instance Document+#

54

101.SCH

101.CAL

101.DEF

101.LAB

101.PRE

104

XBRL Taxonomy Extension Schema Document+#

XBRL Taxonomy Extension Calculation Linkbase Document+#

XBRL Definition Linkbase Document

XBRL Taxonomy Extension Labels Linkbase Document+#

XBRL Taxonomy Extension Presentation Linkbase Document+#

Cover Page Interactive Data File (formatted as inline XBRL and contained in Exhibit 101)

* Indicates a management contract or compensatory plan or arrangement.

+ Indicates this document is filed as an exhibit herewith.

# The financial information of Integra LifeSciences Holdings Corporation Annual Report on Form 10-K for the year ended December 31, 2022 filed on
February 22, 2023 formatted in XBRL (Extensible Business Reporting Language): (i) the Consolidated Statements of Operations, (ii) the Consolidated
Statement of Comprehensive Income (Loss), (iii) the Consolidated Balance Sheets, (iv) Parenthetical Data to the Consolidated Balance Sheets, (v) the
Consolidated Statements of Cash Flows, (vi) the Consolidated Statements of Changes in Stockholders’ Equity, and (vii) Notes to Consolidated Financial
Statements, is furnished electronically herewith.

The Company’s Commission File Number for Reports on Form 10-K, Form 10-Q and Form 8-K is 000-26224.

ITEM 16.

FORM 10-K SUMMARY

None.

55

Pursuant to the requirements of Section 13 of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.

SIGNATURES

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

By:

By:

/s/ Jan De Witte
Jan De Witte
President and Chief Executive Officer
(Principal Executive Officer)

/s/ Jeffrey A. Mosebrook
Jeffrey A. Mosebrook
Senior Vice President, Finance
(Principal Financial Officer and Principal Accounting Officer)

Date: February 22, 2023

56

                            
Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons, on behalf of the registrant in
the capacities indicated. 

Signature

/s/ Jan De Witte
Jan De Witte

/s/ Jeffrey A. Mosebrook
Jeffrey A. Mosebrook

/s/ Stuart M. Essig, Ph.D.
Stuart M. Essig, Ph.D.

/s/ Keith Bradley, Ph.D.
Keith Bradley, Ph.D.

/s/ Shaundra Clay
Shaundra Clay

/s/ Barbara B. Hill
Barbara B. Hill

/s/ Renee Lo
Renee Lo

/s/ Donald E. Morel, Jr., Ph.D.
Donald E. Morel, Jr., Ph.D.

/s/ Raymond G. Murphy
Raymond G. Murphy

/s/ Christian S. Schade
Christian S. Schade

Title

President and Chief Executive Officer,
and Director (Principal Executive Officer)

Date

February 22, 2023

Senior Vice President, Finance
(Principal Financial Officer and Principal Accounting Officer)

February 22, 2023

Chairman of the Board

February 22, 2023

February 22, 2023

February 22, 2023

February 22, 2023

February 22, 2023

February 22, 2023

February 22, 2023

February 22, 2023

Director

Director

Director

Director

Director

Director

Director

57

Report of Independent Registered Public Accounting Firm

To the Board of Directors and Stockholders of Integra LifeSciences Holdings Corporation

Opinions on the Financial Statements and Internal Control over Financial Reporting

We have audited the accompanying consolidated balance sheets of Integra LifeSciences Holdings Corporation and its subsidiaries (the “Company”) as of
December 31, 2022 and 2021, and the related consolidated statements of operations, of comprehensive income, of changes in stockholders’ equity and of cash
flows for each of the three years in the period ended December 31, 2022, including the related notes (collectively referred to as the “consolidated financial
statements”). We also have audited the Company's internal control over financial reporting as of December 31, 2022, based on criteria established in Internal
Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO).

In  our  opinion,  the  consolidated  financial  statements  referred  to  above  present  fairly,  in  all  material  respects,  the  financial  position  of  the  Company  as  of
December  31,  2022  and  2021,  and  the  results  of  its  operations  and  its  cash  flows  for  each  of  the  three  years  in  the  period  ended  December  31,  2022  in
conformity  with  accounting  principles  generally  accepted  in  the  United  States  of  America.  Also  in  our  opinion,  the  Company  maintained,  in  all  material
respects, effective internal control over financial reporting as of December 31, 2022, based on criteria established in Internal Control - Integrated Framework
(2013) issued by the COSO.

Change in Accounting Principle

As discussed in Note 2 to the consolidated financial statements, the Company changed the manner in which it accounts for convertible instruments in 2021.

Basis for Opinions

The Company's management is responsible for these consolidated financial statements, for maintaining effective internal control over financial reporting, and
for  its  assessment  of  the  effectiveness  of  internal  control  over  financial  reporting,  included  in  Management’s  Report  on  Internal  Control  Over  Financial
Reporting  appearing  under  Item  9A.  Our  responsibility  is  to  express  opinions  on  the  Company’s  consolidated  financial  statements  and  on  the  Company's
internal  control  over  financial  reporting  based  on  our  audits.  We  are  a  public  accounting  firm  registered  with  the  Public  Company  Accounting  Oversight
Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the
applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain reasonable
assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud, and whether effective internal
control over financial reporting was maintained in all material respects.

Our audits of the consolidated financial statements included performing procedures to assess the risks of material misstatement of the consolidated financial
statements,  whether  due  to  error  or  fraud,  and  performing  procedures  that  respond  to  those  risks.  Such  procedures  included  examining,  on  a  test  basis,
evidence regarding the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles used
and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. Our audit of internal
control over financial reporting included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness
exists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audits also included performing
such other procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinions.

Definition and Limitations of Internal Control over Financial Reporting

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and
the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over
financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect
the  transactions  and  dispositions  of  the  assets  of  the  company;  (ii)  provide  reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit
preparation of financial statements in accordance with generally accepted accounting principles, and

F-1

that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (iii)
provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have
a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of
effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance
with the policies or procedures may deteriorate.

Critical Audit Matters

The critical audit matter communicated below is a matter arising from the current period audit of the consolidated financial statements that was communicated
or required to be communicated to the audit committee and that (i) relates to accounts or disclosures that are material to the consolidated financial statements
and (ii) involved our especially challenging, subjective, or complex judgments. The communication of critical audit matters does not alter in any way our
opinion on the consolidated financial statements, taken as a whole, and we are not, by communicating the critical audit matter below, providing a separate
opinion on the critical audit matter or on the accounts or disclosures to which it relates.

Surgical Innovation Associates, Inc. Acquisition - Valuation of Developed Technology Intangible Asset

As  described  in  Note  4  to  the  consolidated  financial  statements,  on  December  6,  2022,  the  Company  completed  its  acquisition  of  Surgical  Innovation
Associates,  Inc.  (SIA)  for  an  acquisition  purchase  price  of  $51.5  million,  and  will  pay  up  to  an  additional  $50  million  upon  the  achievement  of  certain
revenue-based performance milestones in 2023, 2024, and 2025 and up to an additional $40.0M upon the approval by the FDA of the Premarketing Approval
Application for DuraSorb. The acquisition also resulted in a $75 million developed technology intangible asset being recorded. The estimated fair value of the
developed  technology  acquired  was  determined  by  management  using  the  multi-period  excess  earnings  method  of  the  income  approach.  Management’s
significant  assumptions  used  in  the  estimate  of  fair  value  included  the  estimated  net  cash  flows,  including  net  revenues,  cost  of  sales,  research  and
development  costs,  selling  and  marketing  costs,  working  capital,  contributory  asset  charges,  discount  rate,  the  asset’s  life  cycle,  and  competitive  trends
impacting the asset and the cash flow stream.

The  principal  considerations  for  our  determination  that  performing  procedures  relating  to  the  valuation  of  developed  technology  intangible  asset  from  the
acquisition of Surgical Innovation Associates, Inc. is a critical audit matter are (i) the significant judgment by management when developing the fair value
estimate of the acquired developed technology intangible asset, (ii) a high degree of auditor judgment , subjectivity, and effort in performing procedures and
evaluating  management’s  significant  assumptions  related  to  net  revenues,  cost  of  sales,  discount  rate  and  the  asset’s  life  cycle;  and  (iii)  the  audit  effort
involved the use of professionals with specialized skill and knowledge.

Addressing the matter involved performing procedures and evaluating audit evidence in connection with forming our overall opinion on the consolidated
financial statements. These procedures included testing the effectiveness of controls relating to the acquisition accounting, including controls over
management’s valuation of the acquired developed technology intangible asset and controls over the development of significant assumptions related to net
revenues, cost of sales, discount rate and the asset’s life cycle. These procedures also included, among others (i) reading the purchase agreement and (ii)
testing management’s process for developing the estimated fair value of the developed technology intangible asset. Testing management’s process included
evaluating the appropriateness of the multi-period excess earnings method, testing the completeness and accuracy of underlying data used in the method, and
evaluating the reasonableness of significant assumptions used by management related to net revenues, cost of sales, discount rate and the asset’s life cycle.
Evaluating the reasonableness of management’s assumptions related to net revenues, cost of sales, and the asset’s life cycle involved considering (i) current
and past performance of the product associated with the developed technology acquired; (ii) the consistency with external market and industry data; and (iii)
whether the assumptions are consistent with evidence obtained in other areas of the audit. Professionals with specialized skill and knowledge were used to
assist in evaluating (i) the appropriateness of the Company’s multi-period excess earnings method and (ii) the reasonableness of the discount rate and the
asset’s life cycle assumptions.

/s/ PricewaterhouseCoopers LLP
Florham Park, New Jersey
February 22, 2023

We have served as the Company’s auditor since 1989.

F-2

 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
CONSOLIDATED STATEMENTS OF OPERATIONS
(Dollars in thousands, except per share amounts)

Total revenue, net

$

1,557,666  $

1,542,448  $

1,371,868 

Years Ended December 31,

2022

2021

2020

Costs and expenses:
Cost of goods sold
Research and development
Selling, general and administrative
Intangible asset amortization
Total costs and expenses

Operating income
Interest income
Interest expense
Gain from sale of businesses
Other income, net
Income before income taxes
Provision (benefit) for income taxes

Net income

Net income per share
       Basic
       Diluted

Weighted average common shares outstanding (See Note 13):

Basic
Diluted

587,355 
101,193 
616,316 
13,882 
1,318,746 
238,920 
11,917 
(49,594)
644 
12,007 
213,894 
33,344 
180,550  $

597,808 
93,051 
637,445 
16,914 
1,345,218 
197,230 
6,737 
(50,395)
41,798 
19,307 
214,677 
45,602 
169,075  $

2.18  $
2.16  $

2.00  $
1.98  $

82,997 
83,516 

84,698 
85,485 

520,834 
77,381 
594,526 
27,757 
1,220,498 
151,370 
9,297 
(71,581)
— 
4,434 
93,520 
(40,372)
133,892 

1.58 
1.57 

84,650 
85,228 

$

$
$

The accompanying notes are an integral part of these consolidated financial statements.

F-3

 
 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME
(Dollars in thousands)

Net income

Other comprehensive (loss) income, before tax:

Change in foreign currency translation adjustments

Unrealized gain (loss) on derivatives

Unrealized derivative gain (loss) arising during period
Less: Reclassification adjustments for gain (loss) included in net income

Unrealized gain (loss) on derivatives

Years Ended December 31,

2022

2021

2020

$

180,550  $

169,075 

$

133,892 

(17,807)

(17,362)

53,363 

104,351 
18,859 
85,492 

68,192 
17,024 
51,168 

(96,837)
(24,442)
(72,395)

Defined benefit pension plan - net gain (loss) arising during period

7,429 

6,998 

4,604 

Total other comprehensive gain (loss), before tax

Income tax (expense) benefit related to items in other comprehensive gain (loss)

Total other comprehensive gain (loss), net of tax

75,114 
(19,694)
55,420 

40,804 
(11,900)
28,904 

(14,428)
16,771 
2,343 

Comprehensive income, net of tax

$

235,970  $

197,979 

$

136,235 

The accompanying notes are an integral part of these consolidated financial statements.

F-4

 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
CONSOLIDATED BALANCE SHEETS
(Dollars in thousands, except per share amounts)

December 31,

2022

2021

ASSETS
Current Assets:

Cash and cash equivalents
Trade accounts receivable, net of allowances of $4,304 and $4,735
Inventories, net
Prepaid expenses and other current assets

Total current assets
Property, plant and equipment, net
Right of use asset - operating leases
Intangible assets, net
Goodwill
Deferred tax assets, net
Other assets

Total assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current Liabilities:

Current portion of borrowings under senior credit facility
Current portion of lease liability - operating leases
Accounts payable, trade
Contract liabilities
Accrued compensation
Accrued expenses and other current liabilities

Total current liabilities

Long-term borrowings under senior credit facility
Long-term borrowings under securitization facility
Long-term convertible securities
Lease liability - operating leases
Deferred tax liabilities
Other liabilities
Total liabilities
Stockholders’ Equity:

Preferred Stock; no par value; 15,000 authorized shares; none outstanding
Common stock; $0.01 par value; 240,000 authorized shares; 90,477 and 89,600 issued at December 31, 2022 and 2021,
respectively
Additional paid-in capital
Treasury stock, at cost; 6,823 and 4,899 shares at December 31, 2022 and 2021, respectively
Accumulated other comprehensive income (loss)

        Retained earnings

Total stockholders’ equity

Total liabilities and stockholders’ equity

$

$

$

$

456,661  $
263,465 
324,583 
116,789 
1,161,498 
311,302 
148,284 
1,126,609 
1,038,881 
45,994 
57,190 
3,889,758  $

38,125  $
14,624 
102,100 
7,253 
78,771 
80,033 
320,906 
733,149 
104,700 
567,341 
157,420 
63,338 
138,501 
2,085,355 

— 

905 
1,276,977 
(362,862)
10,265 
879,118 
1,804,403 
3,889,758  $

513,448 
231,831 
317,386 
91,051 
1,153,716 
311,703 
84,543 
1,145,573 
1,013,458 
56,950 
16,440 
3,782,383 

45,000 
14,775 
61,837 
5,295 
92,656 
120,458 
340,021 
824,257 
112,500 
564,426 
90,329 
45,788 
120,258 
2,097,579 

— 

896 
1,264,943 
(234,448)
(45,155)
698,568 
1,684,804 
3,782,383 

The accompanying notes are an integral part of these consolidated financial statements.

F-5

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
CONSOLIDATED STATEMENTS OF CASH FLOWS
(Dollars in thousands)

OPERATING ACTIVITIES:
Net income
Adjustments to reconcile net income to net cash provided by operating activities:

Depreciation and amortization
Non-cash in-process research and development expense
Non-cash impairment charges
Deferred income tax (benefit) provision
Share-based compensation
Amortization of debt issuance costs and expenses associated with debt refinancing
Non-cash lease expense
Accretion of bond issuance discount
Loss (Gain) on disposal of property and equipment and construction in-progress
Gain from the sale of businesses
Change in fair value of contingent consideration and others

Changes in assets and liabilities:
Accounts receivable
Inventories
Prepaid expenses and other current assets
Other non-current assets
Accounts payable, accrued expenses and other current liabilities
Contract liabilities
Other non-current liabilities

Net cash provided by operating activities

INVESTING ACTIVITIES:
Purchases of property and equipment
Proceeds from sale of business
Acquired in-process research and development and intangibles
Cash paid for business acquisitions, net of cash acquired
Proceeds from sales of property and equipment
Net proceeds (payments) on swaps designated as net investment hedges
Net cash used in investing activities

FINANCING ACTIVITIES:
Proceeds from borrowings of long-term indebtedness
Payments on debt
Purchase of option hedge on convertible notes
Proceeds from convertible notes issuance
Proceeds from sale of stock purchase warrants
Payment of debt issuance costs
Purchase of treasury stock
Proceeds from exercised stock options
Cash taxes paid in net equity settlement
Net cash (used in) provided by financing activities

Effect of exchange rate changes on cash and cash equivalents

Net increase (decrease) in cash and cash equivalents

Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period

Years Ended December 31,

2022

2021

2020

$

180,550 

$

169,075 

$

133,892 

118,299 
— 
— 
(4,585)
27,725 
6,845 
2,816 
— 
(6,813)
(644)
(20,304)

(33,905)
(29,124)
8,612 
(2,182)
17,343 
4,274 
(4,438)

264,469 

(42,343)
23,960 
(4,742)
(51,509)
11,145 
4,909 

(58,580)

40,750 
(148,550)
— 
— 
— 
— 
(125,000)
5,465 
(24,618)

(251,953)

(10,723)

(56,787)
513,448 

119,836 
— 
2,754 
(2,755)
36,210 
7,030 
3,834 
— 
2,240 
(41,798)
(2,162)

7,265 
5,374 
(21,143)
7,875 
32,874 
28 
(14,110)

312,427 

(48,022)
190,468 
(58)
(303,910)
3 
76 

(161,443)

25,500 
(125,500)
— 
— 
— 
(249)
— 
6,824 
(4,801)

(98,226)

(9,476)

43,282 
470,166 

$

456,661 

$

513,448 

$

116,031 
519 
— 
(64,138)
19,590 
12,076 
2,955 
15,415 
7,855 
— 
951 

52,105 
(48,348)
1,632 
13,735 
(57,512)
(37)
(2,889)

203,832 

(38,890)
— 
(25,000)
— 
3,657 
(7,840)

(68,073)

171,500 
(441,000)
(104,248)
575,000 
44,563 
(24,347)
(100,000)
5,232 
(5,075)

121,625 

13,871 

271,255 
198,911 

470,166 

The accompanying notes are an integral part of these consolidated financial statements.

F-6

 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY
(Dollars in thousands)

Balance, January 1, 2020

Net income
Other comprehensive loss, net of tax
Issuance of common stock through employee stock
purchase plan
Issuance of common stock for vesting of share-based
awards, net of shares withheld for taxes
Share-based compensation
Share repurchase and equity component of the
convertible note issuance, net
Accelerated shares repurchased
Adoption of Update No. 2016-13

Balance, December 31, 2020

Net income
Other comprehensive loss, net of tax
Issuance of common stock through employee stock
purchase plan
Issuance of common stock for vesting of share-based
awards, net of shares withheld for taxes
Share-based compensation
Adoption of Update No. 2020-06

Balance, December 31, 2021
Net income
Other comprehensive income (loss), net of tax
Issuance of common stock through employee stock
purchase plan
Issuance of common stock for vesting of share-based
awards, net of shares withheld for taxes
Share-based compensation
Accelerated shares repurchased

Balance, December 31, 2022

Common Stock

Treasury Stock

Shares

Amount

Shares

88,735  $

887 

(2,865) $

Amount
(119,943) $

Additional Paid-In
Capital
1,213,620  $

Accumulated Other
Comprehensive
Income

Retained Earnings

Total Equity

(76,402) $

398,574  $

1,416,736 

— 
— 

13 

503 
— 

— 
— 
— 

89,251 

— 
— 

18 

331 
— 
— 

89,600  $
— 
— 

17 

859 
— 
— 

90,476 

— 
— 

— 

2 
4 

— 
— 
— 

893 

— 
— 

1 
2 
— 

896 
— 
— 

— 

7 
2 
— 

905 

— 
— 

— 

11 
— 

— 
— 

— 

526 
— 

— 
(2,060)
— 

(4,914)

— 
(115,724)
— 

(235,141)

— 
— 

— 

15 
— 
— 

(4,899) $
— 
— 

— 

14 
— 
(1,938)

(6,823)

— 
— 

— 

693 
— 
— 

— 
— 

— 

738 
— 
(129,152)

(362,862)

— 
— 

694 

(1,066)
19,397 

42,539 
15,724 
— 

1,290,908 

— 
— 

1,127 

201 
35,981 
(63,274)

— 
— 

1,078 

(20,974)
27,778 
4,152 

(234,448) $

1,264,943  $

— 
2,343 

133,892 
— 

— 

— 
— 

— 
— 
— 

(74,059)

— 
28,904 

— 

— 
— 
— 

— 

— 
— 

— 
— 
(200)

532,266 

169,075 
— 

— 
— 
(2,773)

(45,155) $
— 
55,420 

698,568  $
180,550 
— 

— 

— 
— 
— 

— 

— 
— 
— 

133,892 
2,343 

694 

(538)
19,401 

42,539 
(100,000)
(200)

1,514,867 

169,075 
28,904 

895 
35,983 
(66,047)

1,684,804 
180,550 
55,420 

1,078 

(20,229)
27,780 
(125,000)

— 

1,127 

1,276,977 

10,265 

879,118 

1,804,403 

The accompanying notes are an integral part of these consolidated financial statements.

F-7

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1. BUSINESS

Integra  LifeSciences  Holdings  Corporation  (the  “Company”)  was  incorporated  in  Delaware  in  1989.  The  Company  is  a  worldwide  leader  in  medical
technology. The Company was founded with the acquisition of an engineered collagen technology platform used to repair and regenerate tissue. Since then,
Integra has developed numerous product lines from this technology for applications ranging from burn and deep tissue wounds to the repair of dura mater in
the brain, as well as nerves and tendons. The Company has expanded its base regenerative technology business to include surgical instruments, neurosurgical
products and advanced wound care through global acquisitions and product development to meet the evolving needs of its customers and enhance patient
care. The Company sells its products directly through various sales forces and through a variety of other distribution channels.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

BASIS OF PRESENTATION

These  financial  statements  and  the  accompanying  notes  are  prepared  in  accordance  with  accounting  principles  generally  accepted  in  the  United  States  of
America and conform to Regulation S-X under the Securities Exchange Act of 1934, as amended.

PRINCIPLES OF CONSOLIDATION

The consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries. Intercompany accounts and transactions have
been eliminated in consolidation. See Note 4, Acquisitions and Divestitures, for details of new subsidiaries included in the consolidation.

USE OF ESTIMATES

The  preparation  of  consolidated  financial  statements  is  in  conformity  with  generally  accepted  accounting  principles  in  the  United  States  ("GAAP")  which
requires management to make estimates and assumptions that affect the reported amount of assets and liabilities, the disclosure of contingent liabilities, and
the reported amounts of revenues and expenses. Significant estimates affecting amounts reported or disclosed in the consolidated financial statements include
allowances  for  doubtful  accounts  receivable  and  sales  returns  and  allowances,  net  realizable  value  of  inventories,  valuation  of  intangible  assets  including
amortization periods for acquired intangible assets, discount rates and estimated projected cash flows used to value and test impairments of long-lived assets
and goodwill, estimates of projected cash flows and depreciation and amortization periods for long-lived assets, computation of taxes, valuation allowances
recorded against deferred tax assets, the valuation of stock-based compensation, valuation of derivative instruments, valuation of contingent liabilities, the fair
value of debt instruments and loss contingencies. These estimates are based on historical experience and on various other assumptions that are believed to be
reasonable under the current circumstances. Actual results could differ from these estimates. As the Company continues to navigate the novel coronavirus
("COVID-19") pandemic and recent variants of the virus as well as the adverse impacts to global economic conditions, supply chain and the operations, there
may be impact to future estimates including, but not limited to, inventory valuations, fair value measurements, goodwill and long-lived asset impairments, the
effectiveness of the Company’s hedging instruments, deferred tax valuation allowances, and allowances for doubtful accounts receivable.

CASH AND CASH EQUIVALENTS

The  Company  considers  all  short-term,  highly  liquid  investments  purchased  with  original  maturities  of  three  months  or  less  to  be  cash  equivalents.  These
investments are carried at cost, which approximates fair value.

TRADE ACCOUNTS RECEIVABLE AND ALLOWANCES FOR DOUBTFUL ACCOUNTS RECEIVABLE

Trade  accounts  receivable  are  recorded  at  the  invoiced  amount  and  do  not  bear  interest.  The  Company  grants  credit  to  customers  in  the  normal  course  of
business, but generally does not require collateral or any other security to support its receivables.

The  Company  evaluates  the  collectability  of  accounts  receivable  based  on  a  combination  of  factors.  The  Company  recognizes  a  provision  for  doubtful
accounts that reflects the Company’s estimate of expected credit losses for trade accounts receivable. In circumstances where a specific customer is unable to
meet  its  financial  obligations  to  the  Company,  a  provision  to  the  allowances  for  doubtful  accounts  is  recorded  against  amounts  due  to  reduce  the  net
recognized receivable to the amount that is reasonably expected to be collected. For all other customers, the Company evaluates measurement of all expected
credit losses for trade receivables held at the reporting date based on historical experience, current conditions, and reasonable and supportable forecasts.

F - 8

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments.
The Company adopted this guidance on January 1, 2020 using a modified retrospective transition method which requires a cumulative-effect adjustment to the
opening balance of retained earnings to be recognized on the date of adoption with no change to financial results reported in prior periods. The cumulative-
effect adjustment recorded on January 1, 2020 was not material. The adoption of this ASU did not have a significant impact on the Company's consolidated
financial  statements  and  related  disclosures.  The  Company's  exposure  to  credit  losses  may  increase  if  its  customers  are  adversely  affected  by  changes  in
healthcare laws, coverage, and reimbursement, economic pressures or uncertainty associated with local or global economic recessions, disruption associated
with the COVID-19 pandemic and recent variants of the virus, and other customer-specific factors. Although the Company has historically not experienced
significant credit losses, it is possible that there could be an adverse impact due to customer and governmental responses to the COVID-19 pandemic.

Provisions to the allowances for doubtful accounts are recorded to selling, general and administrative expenses. Account balances are charged off against the
allowance  when  it  is  probable  that  the  receivable  will  not  be  recovered.  Provision  for  doubtful  accounts,  net  of  recoveries,  associated  with  accounts
receivable, included in selling, general and administrative expense, was charges of $0.2 million for the year ended December 31, 2022, recoveries of $1.1
million, and charges of $3.6 million for the years ended December 31, 2021 and 2020, respectively.

The below table shows the rollforward of the allowance for doubtful accounts for the years ended December 31, 2022, 2021 and 2020:

Dollars in thousands
Year Ended:

Balance at
Beginning of
Period

Charged to
Costs and
Expenses

Other

Deductions

Balance at End
of Period

 December 31, 2022
December 31, 2021
December 31, 2020

$
$
$

4,735 
6,439 
4,303 

238 
(1,059)
3,635 

— 
341 
— 

(669)
(986)
(1,499)

$
$
$

4,304 
4,735 
6,439 

(1)

Deductions primarily relates to allowance for doubtful accounts written off during the year, net of recoveries and other adjustments.

INVENTORIES

Inventories, consisting of purchased materials, direct labor and manufacturing overhead, are stated at the lower of cost, the value determined by the first-in,
first-out method, or net realizable value. Inventories consisted of the following:

Dollars in thousands
Finished goods
Work in process
Raw materials

Total inventories, net

December 31,

2022

2021

172,088  $
70,598 
81,897 
324,583  $

162,528 
65,323 
89,535 
317,386 

$

At each balance sheet date, the Company evaluates inventories for excess quantities, obsolescence or shelf life expiration. This evaluation includes analysis of
historical sales levels by product, projections of future demand, the risk of technological or competitive obsolescence for products, general market conditions,
a  review  of  the  shelf  life  expiration  dates  for  products,  as  well  as  the  feasibility  of  reworking  or  using  excess  or  obsolete  products  or  components  in  the
production  or  assembly  of  other  products  that  are  not  obsolete  or  for  which  there  are  not  excess  quantities  in  inventory.  To  the  extent  that  management
determines there are excess or obsolete inventory or quantities with a shelf life that is too near its expiration for the Company to reasonably expect that it can
sell those products prior to their expiration, the Company adjusts the carrying value to estimated net realizable value.

The  Company  capitalizes  inventory  costs  associated  with  certain  products  prior  to  regulatory  approval,  based  on  management's  judgment  of  probable
economic benefit. The Company could be required to expense previously capitalized costs related to pre-approval inventory upon a change in such judgment,
due to, among other potential factors, a denial or delay of approval by necessary regulatory bodies or a decision by management to discontinue the related
development program. No such amounts were capitalized at December 31, 2022 or 2021.

F-9

 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment are stated at historical cost less accumulated depreciation and any impairment charges. The Company provides for depreciation
using the straight-line method over the estimated useful lives of the assets. Leasehold improvements are amortized over the lesser of the lease term or the
useful life. The cost of major additions and improvements is capitalized, while maintenance and repair costs that do not improve or extend the lives of the
respective assets are charged to operations as incurred. The cost of computer software developed or obtained for internal use is accounted for in accordance
with the Accounting Standards Codification 350-40, Internal-Use Software.

Property, plant and equipment balances and corresponding lives were as follows:

Dollars in thousands
Land
Buildings and building improvements
Leasehold improvements
Machinery and production equipment
Demonstration equipment
Information systems and hardware
Furniture, fixtures, and office equipment
Construction-in-progress

Total

Less: Accumulated depreciation

Property, plant and equipment, net

December 31,

2022

2021

Useful Lives

$

$

966  $

14,710 
164,292 
181,780 
3,792 
151,330 
20,286 
103,875 
641,031 
(329,729)
311,302  $

1,512 
19,032 
155,495 
183,270 
2,791 
148,706 
20,921 
94,850 
626,577 
(314,874)
311,703 

5-40 years
1-20 years
3-20 years
4-5 years
1-7 years
1-15 years

Depreciation expense associated with property, plant and equipment was $40.1 million, $39.4 million, and $42.1 million for the years ended December 31,
2022, 2021 and 2020, respectively.

CAPITALIZED INTEREST

The  interest  cost  on  capital  projects,  including  facilities  build-out  and  internal  use  software,  is  capitalized  and  included  in  the  cost  of  the  project.
Capitalization commences with the first expenditure for the project and continues until the project is substantially complete and ready for its intended use.
When  no  debt  is  incurred  specifically  for  a  project,  interest  is  capitalized  on  project  expenditures  using  the  weighted  average  cost  of  the  Company's
outstanding borrowings. For the years ended December 31, 2022 and 2021, respectively, the Company capitalized $1.4 million and $1.2 million of interest
expense into property, plant and equipment.

ACQUISITIONS

Results of operations of acquired companies are included in the Company’s results of operations as of the respective acquisition dates. The Company accounts
for the acquisition of a business in accordance with ASC 805, Business Combinations ("ASC Topic 805"). Amounts paid to acquire a business are allocated to
the assets acquired and liabilities assumed based on their fair values at the date of acquisition. Any excess of the purchase price over the fair value of the net
assets acquired is recorded as goodwill. Transaction costs and costs to restructure the acquired company are expensed as incurred.

Contingent  consideration  is  recorded  at  fair  value  as  measured  on  the  date  of  acquisition.  The  value  recorded  is  based  on  estimates  of  future  financial
projections  under  various  potential  scenarios  using  either  a  Monte  Carlo  simulation  or  the  probability-weighted  income  approach  derived  from  revenue
estimates and probability assessment with respect to the likelihood of achieving contingent obligations. Contingent payments related to acquisitions consist of
development, regulatory, and commercial milestone payments, in addition to sales-based payments, and are valued using discounted cash flow techniques.
Each quarter until such contingent amounts are earned, the fair value of the liability is remeasured at each reporting period and adjusted as a component of
operating  expenses  based  on  changes  to  the  underlying  assumptions.  The  change  in  the  fair  value  of  sales-based  payments  is  based  upon  future  revenue
estimates and increases or decreases as revenue estimates or expectation of timing of payment charges. The estimates used to determine the fair value of the
contingent consideration liability are subject to significant judgment and actual results are likely to differ from the amounts originally recorded.

F-10

 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The Company determines the fair value of acquired intangible assets based on detailed valuations that use certain information and assumptions provided by
management. The Company allocates any excess purchase price over the fair value of the net tangible and intangible assets acquired to goodwill. Determining
the  fair  value  of  these  intangible  assets  acquired  as  part  of  a  business  combination  requires  the  Company  to  make  significant  estimates.  These  estimates
include  the  amount  and  timing  of  projected  future  cash  flows,  the  discount  rate  used  to  discount  those  cash  flows  to  present  value,  the  assessment  of  the
asset’s life cycle, and the consideration of legal, technical, regulatory, economic, and competitive risks. The fair value assigned to other intangible assets is
determined by estimating the future cash flows of each project or technology and discounting the net cash flows back to their present values. The discount rate
used is determined at the time of measurement in accordance with accepted valuation methodologies.

Acquired IPR&D is recognized at fair value and initially characterized as an indefinite-lived intangible asset, irrespective of whether the acquired IPR&D has
an alternative future use. The Company uses the income approach to determine the fair value of developed technology and IPR&D acquired in a business
combination.  This  approach  determines  fair  value  by  estimating  the  after-tax  cash  flows  attributable  to  the  respective  asset  over  its  useful  life  and  then
discounting these after-tax cash flows back to a present value. Some of the more significant assumptions inherent in the development of those asset valuations
include  the  estimated  net  cash  flows  for  each  year  for  each  product  including  net  revenues,  cost  of  sales,  R&D  costs,  selling  and  marketing  costs,  the
appropriate  discount  rate  to  select  in  order  to  measure  the  risk  inherent  in  each  future  cash  flow  stream,  the  assessment  of  each  asset’s  life  cycle,  and
competitive  trends  impacting  the  asset  and  each  cash  flow  stream.  The  Company  also  uses  the  income  approach,  as  described  above,  to  determine  the
estimated fair value of certain other identifiable intangible assets including customer relationships, trade names and business licenses. Customer relationships
represent  established  relationships  with  customers,  which  provide  a  ready  channel  for  the  sale  of  additional  products  and  services.  Trade  names  represent
acquired company and product names.

IPR&D acquired in a business combination is capitalized as an indefinite-lived intangible asset. Development costs incurred after the acquisition are expensed
as incurred. Upon receipt of regulatory approval, the indefinite-lived intangible asset is then accounted for as a finite-lived intangible asset and amortized on a
straight-line basis or accelerated basis, as appropriate, over its estimated useful life. If the research and development project is subsequently abandoned, the
indefinite-lived intangible asset is charged to expense. IPR&D acquired outside of a business combination is expensed immediately.

Due to the uncertainty associated with research and development projects, there is risk that actual results will differ materially from the original cash flow
projections  and  that  the  research  and  development  project  will  result  in  a  successful  commercial  product.  The  risks  associated  with  achieving
commercialization include, but are not limited to, delay or failure to obtain regulatory approvals to conduct clinical trials, delay or failure to obtain required
market clearances, delays or issues with patent
issuance, or validity and litigation.

If the acquired net assets do not constitute a business under the acquisition method of accounting, the transaction is accounted for as an asset acquisition and
no  goodwill  is  recognized.  In  an  asset  acquisition,  the  amount  allocated  to  acquired  IPR&D  with  no  alternative  future  use  is  charged  to  expense  at  the
acquisition  date.  Payments  that  would  be  recognized  as  contingent  consideration  in  a  business  combination  are  expensed  when  probable  in  an  asset
acquisition. Refer to Note 4, Acquisitions and Divestitures for more information.

GOODWILL AND OTHER INTANGIBLE ASSETS

The excess of the cost over the fair value of net assets of acquired businesses is recorded as goodwill. Goodwill is not subject to amortization but is reviewed
for  impairment  at  the  reporting  unit  level  annually,  or  more  frequently  if  impairment  indicators  arise.  The  Company's  assessment  of  the  recoverability  of
goodwill is based upon a comparison of the carrying value of goodwill with its estimated fair value. The Company reviews goodwill for impairment in the
third  quarter  every  year  in  accordance  with  ASC  Topic  350,  Intangibles  -  Goodwill  and  Other  ("ASC  Topic  350")  and  whenever  events  or  changes  in
circumstances indicate the carrying value of goodwill may not be recoverable. Refer to Note 7, Goodwill and Other Intangibles for more information.

The  Company  has  two  reportable  segments  with  three  underlying  reporting  units.  Refer  to  Note  16,  Segment  and  Geographic  Information  for  more
information on reportable segments.

Other intangible assets include patents, trademarks, purchased technology, and supplier and customer relationships. Identifiable intangible assets are initially
recorded at fair market value at the time of acquisition generally using an income or cost approach. The Company capitalizes costs incurred to renew or
extend the term of recognized intangible assets and amortizes those costs
over their expected useful lives.

F-11

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The Company tests intangible assets with indefinite lives for impairment annually in the third quarter in accordance with ASC Topic 350. Additionally, the
Company may perform interim tests if an event occurs or circumstances change that could potentially reduce the fair value of an indefinite lived intangible
asset  below  its  carrying  amount.  The  Company  tests  for  impairment  by  either  performing  a  qualitative  evaluation  or  a  quantitative  test.  The  qualitative
evaluation is an assessment of factors, including specific operating results as well as industry, market and general economic conditions, to determine whether
it  is  more  likely  than  not  that  the  fair  values  of  the  intangible  asset  is  less  than  its  carrying  amount.  The  Company  may  elect  to  bypass  this  qualitative
evaluation and perform a quantitative test.

Product rights and other definite-lived intangible assets are tested periodically for impairment in accordance with ASC 350 Topic when events or changes in
circumstances indicate that an asset's carrying value may not be recoverable. The impairment testing involves comparing the carrying amount of the asset or
asset  group  to  the  forecasted  undiscounted  future  cash  flows.  In  the  event  the  carrying  value  of  the  asset  exceeds  the  undiscounted  future  cash  flows,  the
carrying value is considered not recoverable and impairment exists. An impairment loss is measured as the excess of the asset's carrying value over its fair
value, calculated using discounted future cash flows. The computed impairment loss is recognized in the period that the impairment occurs.

LONG-LIVED ASSETS

Long-lived  assets  held  and  used  by  the  Company,  including  property,  plant  and  equipment,  intangible  assets,  and  leases  are  reviewed  for  impairment
whenever  events  or  changes  in  circumstances  indicate  that  the  carrying  amount  of  an  asset  may  not  be  recoverable.  For  purposes  of  evaluating  the
recoverability of long-lived assets to be held and used, a recoverability test is performed using projected undiscounted net cash flows applicable to the long-
lived assets. If an impairment exists, the amount of such impairment is calculated based on the estimated fair value of the asset. Impairments to long-lived
assets to be disposed of are recorded based upon the difference between the carrying value and the fair value of the applicable assets.

INTEGRA FOUNDATION

The  Company  may  periodically  make  contributions  to  the  Integra  Foundation,  Inc.  The  Integra  Foundation  was  incorporated  in  2002  exclusively  for
charitable, educational, and scientific purposes and qualifies under IRC 501(c)(3) as an exempt private foundation. Under its charter, the Integra Foundation
engages in activities that promote health, the diagnosis and treatment of disease, and the development of medical science through grants, contributions and
other appropriate means. The Integra Foundation is a separate legal entity and is not a subsidiary of the Company; therefore, its results are not included in
these  consolidated  financial  statements.  The  Company  contributed  $0.0  million,  $1.2  million  and  $0.8  million  to  the  Integra  Foundation  during  the  years
ended December 31, 2022, 2021 and 2020, respectively. These contributions were recorded in selling, general, and administrative expense.

DERIVATIVES

The Company develops, manufactures, and sells medical devices globally and its earnings and cash flows are exposed to market risk from changes in interest
rates  and  currency  exchange  rates.  The  Company  addresses  these  risks  through  a  risk  management  program  that  includes  the  use  of  derivative  financial
instruments and operates the program pursuant to documented corporate risk management policies. All derivative financial instruments are recognized in the
financial statements at fair value in accordance with the authoritative guidance. Under the guidance, for those instruments that are designated and qualify as
hedging instruments, the hedging instrument must be designated as a fair value hedge, cash flow hedge, or a hedge of a net investment in a foreign operation,
based on the exposure being hedged. The accounting for changes in the fair value of a derivative instrument depends on whether it has been designated and
qualifies as part of a hedging relationship and, further, on the type of hedging relationship. The Company's derivative instruments do not subject its earnings
or cash flows to material risk, and gains and losses on these derivatives generally offset losses and gains on the item being hedged. The Company has not
entered into derivative transactions for speculative purposes. From time to time, the Company may enter into derivatives that are not designated as hedging
instruments in order to protect itself from currency volatility due to intercompany balances.

All derivative instruments are recognized at the fair values as either assets or liabilities on the balance sheet. The Company determines the fair value of its
derivative instruments using the framework prescribed by the authoritative guidance, by considering the estimated amount the Company would receive to sell
or transfer these instruments at the reporting date and by taking into account expected forward interest rates, currency exchange rates, the creditworthiness of
the counterparty for assets, and its creditworthiness for liabilities. In certain instances, the Company utilizes a discounted cash flow model to measure fair
value. Generally, the Company uses inputs that include quoted prices for similar assets or liabilities in active markets, other observable inputs for the asset or
liability and inputs derived principally from, or corroborated by, observable market data by correlation or other means. The Company has classified all of its
derivative assets and liabilities within Level 2 of the fair value hierarchy because observable inputs are available for substantially the full term of its derivative
instruments. The Company classifies derivatives designated as hedges in the same category as the item being hedged for cash flow presentation purposes.

F-12

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The  Company  entered  into  foreign  currency  forward  and  foreign  currency  swap  contracts  that  are  not  designated  as  hedging  instruments  for  accounting
purposes. These contracts are recorded at fair value, with the changes in fair value recognized into other income, net, on the consolidated financial statements.
Refer to Note 6, Derivative Instruments for more information.

FOREIGN CURRENCY

All assets and liabilities of foreign subsidiaries which have a functional currency other than the U.S. dollar are translated at the rate of exchange at year-end,
while elements of the income statement are translated at the average exchange rates in effect during the year. The net effect of these translation adjustments is
shown as a component of accumulated other comprehensive income (loss). These currency translation adjustments are not currently adjusted for income taxes
as they relate to permanent investments in non-U.S. subsidiaries. Foreign currency transaction net losses of $3.3 million, net gains of less than $0.1 million,
and  net  losses  $1.6  million  are  reported  in  other  income,  net  in  the  statements  of  operations,  for  the  year  ended  December  31,  2022,  2021  and  2020,
respectively.

INCOME TAXES

Income  taxes  are  accounted  for  by  using  the  asset  and  liability  method.  Deferred  tax  assets  and  liabilities  are  recognized  for  the  estimated  future  tax
consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax basis. A
valuation allowance is provided when it is more likely than not that some portion or all of the deferred tax assets will not be realized. The effect on deferred
tax assets and liabilities of a change in tax rates is recognized in income in the period when the change is enacted.

The Company recognizes a tax benefit from an uncertain tax position only if it is more likely than not to be sustained upon examination based on the technical
merits  of  the  position.  Reserves  are  established  for  positions  that  don't  meet  this  recognition  threshold.  The  reserve  is  measured  as  the  largest  amount  of
benefit determined on a cumulative probability basis that the Company believes is more likely than not to be realized upon ultimate settlement of the position.
These reserves are classified as long-term liabilities in the consolidated balance sheets of the Company, unless the reserves are expected to be paid in cash
during the next twelve months, in which case they are classified as current liabilities. The Company also records interest and penalties accrued in relation to
uncertain tax benefits as a component of income tax expense.

While the Company believes it has identified all reasonable exposures and the reserve it has established is appropriate under the circumstances, it is possible
that additional exposures exist and that exposures may be settled at amounts different than the amounts reserved. It is also possible that changes in facts and
circumstances could cause the Company to either materially increase or reduce the carrying amount of its tax reserve.

The Company continues to indefinitely reinvest substantially all of its foreign earnings unless there is a manner under which to remit the earnings without a
material tax cost. The current provisional analysis indicates that the Company has sufficient U.S. liquidity, including borrowing capacity, to fund foreseeable
U.S. cash needs without requiring the repatriation of foreign cash. One time or unusual items that may impact the ability or intent to keep the foreign earnings
and cash indefinitely reinvested include significant U.S. acquisitions, loans from a foreign subsidiary and changes in tax laws.

REVENUE RECOGNITION

Revenue  is  recognized  upon  the  transfer  of  control  of  promised  products  or  services  to  the  customers  in  an  amount  that  reflects  the  consideration  the
Company expects to receive in exchange for those products and services.

Total revenue, net, includes product sales, product royalties and other revenues, such as fees received from services.

For products shipped with FOB shipping point terms, the control of the product passes to the customer at the time of shipment. For shipments in which the
control of the product is transferred when the customer receives the product, the Company recognizes revenue upon receipt by the customer. Certain products
that the Company produces for private label customers have no alternative use and the Company has a right of payment for performance to date. Revenues
from  those  products  are  recognized  over  the  period  that  the  Company  manufactures  these  products,  which  is  typically  one  month  to  three  months.  The
Company  uses  the  input  method  to  measure  the  manufacturing  activities  completed  to  date,  which  depicts  the  progress  of  the  Company's  performance
obligation of transferring control of goods being manufactured for private label customers.

A  portion  of  the  Company's  product  revenue  is  generated  from  consigned  inventory  maintained  at  hospitals  and  distributors,  and  also  from  inventory
physically held by field sales representatives. For these types of products sales, the Company retains control until the product has been used or implanted, at
which time revenue is recognized.

F-13

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Revenues from sale of products and services are evidenced by either a contract with the customer or a valid purchase order and an invoice which includes all
relevant terms of sale. For product sales, invoices are generally issued upon the transfer of control (or upon the completion of the manufacturing in the case of
the private label transactions recognized over time) and are typically payable 30 days after the invoice date. The Company performs a review of each specific
customer's  creditworthiness  and  ability  to  pay  prior  to  acceptance  as  a  customer.  Further,  the  Company  performs  periodic  reviews  of  its  customers'
creditworthiness prospectively. Refer to Note 3, Revenue From Contracts With Customers for more information. The Company also maintains a provision for
estimated returns and allowances in the same period that the related revenue is recorded. This reserve is based upon an analysis of actual credit memos issued
for pricing issues or returned goods over an extended period, as well as assumptions about outstanding accounts receivable and judgment in interpreting the
data.

RESEARCH AND DEVELOPMENT

Research and development costs, including salaries, depreciation, consultant and other external fees, and facility costs directly attributable to research and
development activities, are expensed in the period in which they are incurred.

EMPLOYEE TERMINATION BENEFITS

The Company does not have a written severance plan, and it does not offer similar termination benefits to affected employees in all restructuring initiatives.
Accordingly, in situations where minimum statutory termination benefits must be paid to the affected employees, the Company records employee severance
costs  associated  with  these  restructuring  activities  in  accordance  with  the  authoritative  guidance  for  non-retirement  post-employment  benefits.  Charges
associated  with  these  activities  are  recorded  when  the  payment  of  benefits  is  probable  and  can  be  reasonably  estimated.  In  all  other  situations  where  the
Company  pays  out  termination  benefits,  including  supplemental  benefits  paid  in  excess  of  statutory  minimum  amounts  and  benefits  offered  to  affected
employees based on management's discretion, the Company records these termination costs in accordance with the authoritative guidance for ASC Topic 712
Compensation - Nonretirement Benefits and ASC Topic 420 One-time Employee Termination Benefits.

The timing of the recognition of charges for employee severance costs other than minimum statutory benefits depends on whether the affected employees are
required to render service beyond their legal notification period in order to receive the benefits. If affected employees are required to render service beyond
their legal notification period, charges are recognized over the future service period. Otherwise, charges are recognized when management has approved a
specific plan and employee communication requirements have been met.

The  Company  incurred  employee  termination  costs  on  restructuring  activities  associated  with  a  closure  of  a  manufacturing  facility  in  France  and  other
reorganization  projects  in  the  consolidated  statement  of  operations  for  the  year  ended  December  31,  2022.  In  2021,  the  Company  incurred  employee
termination  costs  on  restructuring  activities  associated  with  the  closure  of  a  manufacturing  facility  in  France.  The  following  table  summarizes  our
restructuring  related  accrual  balances  included  within  accrued  expenses  and  other  current  liabilities  in  the  consolidated  balance  sheet  for  the  year  ended
December 31, 2022 and 2021.

(Dollars in thousands)

Balance, beginning of the year
Charges:

Cost of Goods Sold
Research and development
Selling, general and administrative

Payments and other adjustments

Balance, end of the year

Years Ended December 31,

2022

2021

$

$

$
$
$

10,226 

1,494 
72
5,582 
(12,267)
5,107 

$

$

$
$
$

6,372 

3,436 
288
466 
(336)
10,226 

Included  in  the  accrual  balance  as  of  December  31,  2022  is  $2.0  million  related  to  the  closure  of  a  manufacturing  facility  located  in  France,  and  other
reorganization projects of $3.1M. Included in the accrual balance as of December 31, 2021 is $10.2 million related to the closure of the manufacturing facility
located in France.

STOCK-BASED COMPENSATION

Relevant authoritative guidance requires companies to recognize the expense related to the fair value of their stock-based compensation awards. Stock-based
compensation  expense  for  stock  option  awards  are  based  on  the  grant  date  fair  value  using  the  binomial  distribution  model.  The  Company  recognizes
compensation expense for stock option awards, restricted stock awards, performance stock awards and contract stock awards over the requisite service period
of  the  award.  All  excess  tax  benefits  and  taxes  and  tax  deficiencies  from  stock-based  compensation  are  included  in  provision  for  income  taxes  in  the
consolidated statement of operations. Refer to Note 9, Stock-based Compensation for more information.

F-14

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

PENSION BENEFITS

The  Company  maintains  defined  benefit  pension  plans  that  cover  certain  employees  in  France,  Japan,  Germany  and  Switzerland.  Various  factors  are
considered in determining the pension liability, including the number of employees expected to be paid their salary levels and years of service, the expected
return on plan assets, the discount rate used to determine the benefit obligations, the timing of benefit payments and other actuarial assumptions.

Retirement benefit plan assumptions are reassessed on an annual basis or more frequently if changes in circumstances indicate a re-evaluation of assumptions
are required. The key benefit plan assumptions are the discount rate and expected rate of return on plan assets. The discount rate is based on average rates on
bonds that matched the expected cash outflows of the benefit plans. The expected rate of return is based on historical and expected returns on the various
categories of plan assets.

The Company uses the corridor approach in measuring the amount of net periodic benefit pension cost to recognize each period. The corridor approach defers
all actuarial gains and losses resulting from variances between actual results and actuarial assumptions. Those unrecognized gains and losses are amortized
when the net gains and losses exceed 10% of the greater of the market-related value of plan assets or the projected benefit obligation at the beginning of the
year. The amount in excess of the corridor is amortized over the average remaining service period to retirement date of active plan participants.

Deferred Compensation Plan

The Company maintains a deferred compensation plan in which certain employees of the Company may defer the payment and taxation of up to 75% of their
base salary and up to 100% of bonus amounts and other eligible cash compensation.

This deferred compensation is invested in funds offered under the Plan and is valued based on Level 1 measurements in the fair value hierarchy. The purpose
of  the  plan  is  to  retain  key  employees  by  providing  them  with  an  opportunity  to  defer  a  portion  of  their  compensation  as  elected  by  the  participant  in
accordance with the plan. Any amounts set aside to defray the liabilities assumed by the Company will remain the general assets of the Company until such
amounts are distributed to the participants. Assets of the Company's deferred compensation plan are included in Other current assets and recorded at fair value
based on their quoted market prices.

CONCENTRATION OF CREDIT RISK

Financial instruments, which potentially subject the Company to concentrations of credit risk, consist principally of cash and cash equivalents, which are held
at major financial institutions, investment-grade marketable debt securities and trade receivables.

The Company's products are sold on an uncollateralized basis and on credit terms based upon a credit risk assessment of each customer. A portion of the
Company's trade receivables to customers outside the United States includes sales to foreign distributors, who then sell to government owned or supported
healthcare systems.

None of the Company's customers accounted for 10% or more of the consolidated net sales during the years ended December 31, 2022, 2021 and 2020.

RECENT ACCOUNTING PRONOUNCEMENTS

In December 2019, the FASB issued ASU 2019-12, Income Taxes:  Simplifying  the  Accounting  for  Income  Taxes,  intended  to  simplify  the  accounting  for
income  taxes  by  eliminating  certain  exceptions  related  to  the  approach  for  intra-period  tax  allocation,  the  methodology  for  calculating  income  taxes  in  an
interim period and the recognition of deferred tax liabilities for outside basis differences. This guidance also simplifies aspects of the accounting for franchise
taxes and enacted changes in tax laws or rates and clarifies the accounting for transactions that result in a step-up in the tax basis of goodwill. The standard is
effective for annual periods beginning after December 15, 2020 and interim periods within, with early adoption permitted. The Company adopted ASU 2019-
12 as of January 1, 2021. Adoption of the standard requires certain changes to be made prospectively, with some changes to be made retrospectively. The
adoption of this guidance did not have a significant impact on the Company's consolidated financial statements and related disclosures.

F-15

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

In  March  2020,  the  FASB  issued  ASU  2020-04,  Reference  Rate  Reform  (Topic  848),  and  subsequent  amendment  to  the  initial  guidance:  ASU  2021-01,
Reference  Rate  Reform  (Topic  848):  Scope  (collectively,  “Topic  848”).  Topic  848  provides  optional  expedients  and  exceptions  for  applying  GAAP  to
contracts, hedging relationships, and other transactions affected by reference rate reform if certain criteria are met. The amendments apply only to contracts,
hedging relationships, and other transactions that reference London Inter-Bank Offered Rate ("LIBOR") or another reference rate expected to be discontinued
because of reference rate reform. The guidance generally can be applied from March 12, 2020 through December 31, 2022. On October 5, 2022, the FASB
approved an extension of the sunset date of the reference rate reform from December 31, 2022 to December 31, 2024, past LIBOR’s end date. The Company
currently has contracts that are indexed to LIBOR and are continuing to evaluate the scope of impacted contracts and potential risk. The Company expects all
LIBOR-based  contracts  to  be  replaced  by  the  Secured  Overnight  Financing  Rate  (“SOFR”),  which  is  calculated  based  on  overnight  transactions  under
repurchase agreements backed by Treasury securities. The Alternative Reference Rates Committee, a group of private-market participants convened by the
U.S. Federal Reserve Board and the New York Federal Reserve, has recommended the use of SOFR as a more robust reference rate alternative to LIBOR. The
use  of  SOFR  as  a  substitute  for  LIBOR  is,  however,  voluntary  and  may  not  be  suitable  for  all  market  participants.  There  can  be  no  assurance  that  the
replacement rate will be economically equivalent to LIBOR, which could result in higher interest rates for us under our debt facilities. There is no guarantee
that a transition from LIBOR to SOFR will not result in financial market disruptions, significant increases in benchmark rates, or our borrowing costs, any of
which could have an adverse effect on our business, results of operations and financial condition.

In August 2020, the FASB issued ASU 2020-06, Debt- Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging-Contracts
in  Entity's  Own  Equity  (Subtopic  815-40):Accounting  for  Convertible  Instruments  and  Contracts  in  an  Entity's  Own  Equity.  The  guidance  simplifies
accounting for convertible instruments by removing major separation models required under current GAAP. Consequently, more convertible debt instruments
will  be  reported  as  a  single  liability  instrument  with  no  separate  accounting  for  embedded  conversion  features.  The  ASU  removes  certain  settlement
conditions that are required for equity contracts to qualify for the derivative scope exception, which will permit more equity contracts to qualify. The guidance
also  simplifies  the  diluted  net  income  per  share  calculation  in  certain  areas.  The  ASU  will  be  effective  for  annual  and  interim  periods  beginning  after
December 15, 2021, and early adoption is permitted for fiscal years beginning after December 15, 2020, and interim periods within those fiscal years using
either the modified retrospective or full retrospective method.

As detailed in Note 5, Debt, on February 4, 2020, the Company issued $575.0 million aggregate principal amount of its 0.5% Convertible Senior Notes due
2025 (the "2025 Notes"). The 2025 Notes are subject to the guidance included in ASU 2020-06. The Company adopted this guidance on January 1, 2021
using  the  modified  retrospective  approach  which  resulted  in  a  cumulative-effect  adjustment  that  increased  (decreased)  the  following  consolidated  balance
sheet accounts:

ADJUSTMENT

CONSOLIDATED BALANCE SHEET CLASSIFICATION

Deferred tax impact of cumulative-effect adjustment
Debt discount reclassification
Equity issuance costs reclassification
Debt discount amortization and equity costs
reclassification, net of tax
Net impact of cumulative-effect adjustment

Deferred tax liabilities
Long-term convertible securities
Long-term convertible securities

Retained Earnings
Additional paid-in capital

AMOUNT
 (in millions)

$

(20.6)
89.1 
(2.5)

(2.8)
(63.3)

On December 9, 2020, the Company made an irrevocable election under the indenture to require the principal portion of its 2025 Notes to be settled in cash
and any excess in shares. Following the irrevocable notice, only the amounts settled in excess of the principal will be considered in diluted earnings per share
under  the  “if-converted”  method.  Upon  adoption  of  ASU  2020-06,  the  Company’s  2025  Notes  were  reflected  entirely  as  a  liability  since  the  embedded
conversion feature will no longer be separately presented within stockholders’ equity. Additionally, from January 1, 2021, the Company is no longer incurring
non-cash interest expense for the amortization of debt discount.

In October 2020, the FASB issued ASU 2020-10, Codification Improvements, which updates various codification topics by clarifying or improving disclosure
requirements to align with the regulations of the U.S. Securities and Exchange Commission (the "SEC") . The ASU has been effective for the Company for
annual and interim periods beginning after January 1, 2021. The Company adopted this standard on the January 1, 2021. The adoption of this guidance did not
have a significant impact on the Company's consolidated financial statements and related disclosures.

F-16

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

In May 2021, the FASB issued ASU 2021-04, Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation
—Stock  Compensation  (Topic  718),  and  Derivatives  and  Hedging—Contracts  in  Entity’s  Own  Equity  (Subtopic  815-40):  Issuer’s  Accounting  for  Certain
Modifications or Exchanges of Freestanding Equity-Classified Written Call Options which provides guidance to clarify and reduce diversity in an issuer’s
accounting  for  modifications  or  exchanges  of  freestanding  equity-classified  written  call  options  (for  example,  warrants)  that  remain  equity  classified  after
modification or exchange. The amendments in this ASU No. 2021-04 are effective for all entities for fiscal years beginning after December 15, 2021, and
interim periods within those fiscal years, with early adoption permitted, including interim periods within those fiscal years. The amendment currently has no
impact to the Company as the effect will largely depend on the terms of written call options or financings issued or modified in the future.

There are no other recently issued accounting pronouncements that are expected to have any significant effect on the Company's financial position, results of
operations or cash flows.

SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION

Cash paid for interest during the years ended December 31, 2022, 2021 and 2020 was $42.2 million (net of $1.4 million that was capitalized into construction
in progress), $43.2 million (net of $1.2 million that was capitalized into construction in progress) and $47.3 million (net of $2.3 million that was capitalized
into construction in progress), respectively.

Cash  paid  for  income  taxes,  net  of  refunds,  for  the  years  ended  December  31,  2022,  2021  and  2020  was  $35.9  million,  $49.5  million  and  $29.8  million,
respectively.

NON-CASH INVESTING AND FINANCING ACTIVITIES

Property  and  equipment  purchases  included  in  liabilities  at  December  31,  2022,  2021  and  2020  were  $10.5  million,  $4.7  million  and  $1.6  million,
respectively.

During the fourth quarter of 2021, the Company achieved its final developmental milestone which triggered a $5.0 million obligation to be paid to former
shareholders of Rebound Therapeutics Corporation ("Rebound"). The Company recorded $5.0 million as an intangible asset in the consolidated balance sheet
upon  achieving  the  milestone.  The  remaining  obligation  was  included  in  accrued  liabilities  at  December  31,  2021  in  the  consolidated  balance  sheets.  The
milestone was fully paid in 2022.

During the fourth quarter of 2020, the Company achieved another developmental milestone which triggered a $20.0 million obligation to be paid to the former
shareholders of Rebound. The Company recorded $20.0 million as an intangible asset in the consolidated balance sheet upon achieving the milestone. The
milestone was paid during the fourth quarter of 2020.

3. REVENUES FROM CONTRACTS WITH CUSTOMERS

Summary of Accounting Policies on Revenue Recognition

Revenue  is  recognized  upon  the  transfer  of  control  of  promised  products  or  services  to  the  customers  in  an  amount  that  reflects  the  consideration  the
Company expects to receive in exchange for those products and services.

Performance Obligations

The Company's performance obligations consist mainly of transferring control of goods and services identified in the contracts, purchase orders, or invoices.
The Company has no significant multi-element contracts with customers.

Significant Judgments

Usage-based royalties and licenses are estimated based on the provisions of contracts with customers and recognized in the same period that the royalty-based
products are sold by the Company's strategic partners. The Company estimates and recognizes royalty revenue based upon communication with licensees,
historical information, and expected sales trends. Differences between actual reported licensee sales and those that were estimated are adjusted in the period in
which they become known, which is typically the following quarter. Historically, such adjustments have not been significant.

The  Company  estimates  returns,  price  concessions,  and  discount  allowances  using  the  expected  value  method  based  on  historical  trends  and  other  known
factors. Rebate allowances are estimated using the most likely method based on each customer contract.

The Company's return policy, as set forth in its product catalogs and sales invoices, requires review and authorization in advance prior to the return of product.
Upon the authorization, a credit will be issued for the goods returned within a set amount of days from the shipment, which is generally 90 days.

F-17

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The  Company  disregards  the  effects  of  a  financing  component  if  the  Company  expects,  at  contract  inception,  that  the  period  between  the  transfer  and
customer  payment  for  the  goods  or  services  will  be  one  year  or  less.  The  Company  has  no  significant  revenues  recognized  on  payments  expected  to  be
received more than one year after the transfer of control of products or services to customers.

Contract Asset and Liability

Revenues  recognized  from  the  Company's  private  label  business  that  are  not  invoiced  to  the  customers  as  a  result  of  recognizing  revenue  over  time  are
recorded  as  a  contract  asset  included  in  the  prepaid  expenses  and  other  current  assets  account  in  the  consolidated  balance  sheet.  Upon  invoicing  to  the
customer, the balance is recorded in trade receivable, net in the consolidated balance sheet.

Other operating revenues may include fees received under service agreements. Non-refundable fees received under multiple-period service agreements are
recognized as revenue as the Company satisfies the performance obligations to the other party. A portion of the transaction price allocated to the performance
obligations to be satisfied in the future periods is recognized as contract liability.

The following table summarized the changes in the contract asset and liability balances for the year ended December 31, 2022:

Dollars in thousands
Contract Asset

Contract asset, January 1, 2022

Transferred to trade receivable from contract asset included
     in beginning of the year contract asset
Contract asset, net of transferred to trade receivables on contracts during the period

Contract asset, December 31, 2022

Contract Liability

Contract liability, January 1, 2022

Recognition of revenue included in beginning of year contract liability
Contract liability, net of revenue recognized on contracts during the period
Foreign currency translation

Contract liability, December 31, 2022

Total

11,412 

(11,412)
10,122 
10,122 

11,946 
(5,349)
9,596 
(66)
16,127 

$

$

$

$

At December 31, 2022, the short-term portion of the contract liability of $7.3 million and the long-term portion of $8.8 million is included in current liabilities
and other liabilities, respectively, in the consolidated balance sheet.

As of December 31, 2022, the Company is expected to recognize revenue of approximately $7.3 million in 2023, $4.2 million in 2024, $2.7 million in 2025,
$1.1 million in 2026, $0.7 million in 2027, and $0.1 million thereafter.

Shipping and Handling Fees

The Company elected to account for shipping and handling activities as a fulfillment cost rather than a separate performance obligation. Amounts billed to
customers for shipping and handling are included as part of the transaction price and recognized as revenue when control of underlying products is transferred
to the customer. The related shipping and freight charges incurred by the Company are included in the cost of goods sold.

Product Warranties

Certain of the Company's medical devices, including monitoring systems and neurosurgical systems, are designed to operate over long periods of time. These
products are sold with warranties which may extend for up to two years from the date of purchase. The warranties are not considered a separate performance
obligation. The Company estimates its product warranties using the expected value method based on historical trends and other known factors. The Company
includes them in accrued expenses and other current liabilities in the consolidated balance sheet.

Taxes Collected from Customers

The Company elected to exclude from the measurement of the transaction price all taxes assessed by a governmental authority that are both imposed on and
concurrent with a specific revenue-producing transaction and collected by the entity from a customer.

F-18

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Disaggregated Revenue

The following table presents revenues disaggregated by the major sources of revenues for years-ended December 31, 2022, 2021 and 2020 (dollar amounts in
thousands):

Neurosurgery
Instruments

Total Codman Specialty Surgical

Wound Reconstruction and Care
Extremity Orthopedics
Private Label

(1)

(2)(3)

Total Tissue Technologies

Total revenue

Year Ended December
31, 2022

Year Ended December
31, 2021

Year Ended December
31, 2020

$

$

794,017  $
225,547 
1,019,564 

406,689 
— 
131,413 
538,102 
1,557,666  $

802,959  $
222,273 
1,025,232 

392,463 
— 
124,753 
517,216 
1,542,448  $

716,339 
178,492 
894,831 

293,038 
78,316 
105,683 
477,037 
1,371,868 

(1)

 On January 4, 2021, the Company completed its sale of its Extremity Orthopedics business. See Note 4, Acquisitions and Divestitures, for details

(2)

 See Note 4. Acquisitions and Divestitures, for details around the ACell acquisition.

(3)

 On August 31, 2022, the Company completed the sale of its non-core traditional wound care ("TWC") business. See Note 4, Acquisitions and Divestitures

See Note 16, Segment and Geographical Information, for details of revenues based on the location of the customer.

4. ACQUISITIONS AND DIVESTITURES

Surgical Innovation Associates, Inc. Acquisition

On  December  6,  2022,  the  Company  completed  its  acquisition  of  Surgical  Innovation  Associates,  Inc.  ("SIA")  for  an  acquisition  purchase  price  of
$51.5  million.  In  addition  to  the  purchase  price,  the  acquisition  includes  two  separate  contingent  considerations  payments,  which  are  dependent  on  1)
achieving certain revenue-based performance milestones in 2023, 2024, and 2025 (up to $50.0 million in additional payments), as well as 2) the approval by
the FDA of the Premarket Approval (“PMA”) Application for DuraSorb for certain uses by certain timing targets (up to $40.0 million in additional payments).
SIA's core technology, DuraSorb, is a fully resorbable scaffold of a globally accepted polymer, which is cleared for use in hernia repair, abdominal wall, and
other soft tissue reinforcement. DuraSorb sales will be reported within Integra’s Tissue Technologies segment as part of its Wound Reconstruction and Care
franchise.

Assets Acquired and Liabilities Assumed at Fair Value

The SIA Acquisition has been accounted for using the acquisition method of accounting. This method requires that assets acquired, and liabilities assumed in
a business combination to be recognized at their fair values as of the acquisition date.

F-19

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The following table summarizes the fair values of the assets acquired and liabilities assumed at the acquisition date:

Dollars in thousands
Current assets:

Cash
Trade accounts receivable, net
Inventories, net
Prepaid expenses and other current assets
Total current assets

Intangible assets
Goodwill
Total assets acquired

Current liabilities:

Accounts payable and accrued expenses
Total current liabilities

Deferred Tax Liability
Contingent consideration
Total liabilities assumed

Net assets acquired

Developed Technology

Valuation as of December 6, 2022

Weighted Average Life

14 years

$

$

$

$
$

$

4,438 
1,551 
2,900 
1,654 
10,543 
75,000 
41,854 
127,397 

2,044 
2,044 
11,799 
57,607 
71,450 

55,947 

The estimated fair value of the developed technology was determined using the multi-period excess earnings method of the income approach, which estimates
value based on the present value of future economic benefits. Some of the more significant assumptions inherent in the development of those asset valuations
include the estimated net cash flows for each year for each product including net revenues, cost of sales, R&D costs, selling and marketing costs, working
capital,  and  contributory  asset  charges,  the  appropriate  discount  rate  to  select  in  order  to  measure  the  risk  inherent  in  each  future  cash  flow  stream,  the
assessment of the asset’s life cycle, and competitive trends impacting the asset and the cash flow stream.

The Company used a discount rate of 18% to arrive at the present value for the acquired intangible assets to reflect the rate of return a market participant
would expect to earn and incremental commercial uncertainty in the cash flow projections. No assurances can be given that the underlying assumptions used
to prepare the discounted cash flow analysis will not change. For these and other reasons, actual results may vary significantly from estimated results.

Goodwill

The Company allocated goodwill related to the SIA Acquisition to the Tissue Technologies segment. Goodwill is the excess of the consideration transferred
over the net assets recognized and represents the expected revenue and cost synergies of the combined company and assembled workforce. A key factor that
contributes to the recognition of goodwill, and a driver for the Company’s acquisition of SIA, is the attractive growth opportunities presented by the surgical
matrix business in the breast reconstruction market. Goodwill recognized as a result of this acquisition is non-deductible for income tax purposes.

Contingent Consideration

The Company determines the acquisition date fair value of contingent consideration obligations based on a probability-weighted income approach derived
from revenue estimates and a probability assessment with respect to the likelihood of achieving contingent obligations. The fair value measurement is based
on  significant  inputs  not  observable  in  the  market  and  thus  represents  a  Level  3  measurement  as  defined  using  the  fair  value  concepts  in  ASC  820.  The
resulting most likely payouts are discounted using an appropriate effective annual interest rate. At each reporting date, the contingent consideration obligation
will be revalued to estimated fair value and changes in fair value will be reflected as income or expense in the consolidated statement of operations. Changes
in the fair value of the contingent considerations may result from changes in discount periods and rates and changes in the timing and amount of revenue
estimates.  Changes  in  assumptions  utilized  in  the  contingent  consideration  fair  value  estimates  could  result  in  an  increase  in  the  contingent  consideration
obligation and a corresponding charge to operating results.

As part of the acquisition, the Company is required to pay to the shareholder of SIA up to $90.0 million for two separate payments, which are dependent on 1)
achieving certain revenue-based performance milestones in 2023, 2024, and 2025 (up to $50.0 million in additional payments), as well as 2) the approval by
the FDA of the PMA for DuraSorb for certain uses by

F-20

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

certain timing targets (up to $40.0 million in additional payments). The Company used iterations of the Monte Carlo simulation to calculate the fair value of
the  contingent  consideration  for  the  revenue-based  milestone  that  considered  the  possible  outcomes  of  scenarios  related  to  each  specific  milestone  for  the
revenue based performance milestone. The Company used probabilities of achieving the conditions to calculate the fair value of the contingent consideration
for the PMA approval milestone. The Company estimated the fair value of the contingent consideration for the revenue based milestone to be $32.6 million at
the acquisition date and $25.0 million for the PMA approval milestone.

Deferred Tax Liabilities

Deferred tax liabilities result from identifiable intangible assets’ fair value adjustments. These adjustments create excess book basis over tax basis which is
tax-effected by the statutory tax rates of applicable jurisdictions.

Sale of non-core traditional wound care business

On August 31, 2022, the Company completed its sale of its non-core traditional wound care ("TWC") business to Gentell, LLC ("Gentell") for $28.8 million,
which  consists  of  $27.8  million  in  cash  plus  $1.0  million  in  contingent  consideration  which  may  be  received  upon  achieving  certain  revenue-based
performance milestones two years after the closing date. The proceeds from the sale of the TWC business of $27.8 million is presented in the consolidated
statement of cash flows net of cash transferred of $3.5 million and other transaction fees. The transaction included the sale of the Company's TWC products,
such  as  sponges,  gauze  and  conforming  bandages,  and  certain  advanced  wound  care  dressings,  such  as  supportive,  calcium  alginate,  hydrogel,  and  foam
dressings.

The divestiture did not represent a strategic shift that had a major effect on the Company's operations and financial statements. Goodwill was allocated to the
assets and liabilities divested using the relative fair value method of the TWC business to the Company's Tissue Technologies reportable business segment. In
connection with the sale, the Company recognized $0.6 million as a gain from the sale of the business in the consolidated statement of operations for the year
ended December 31, 2022. The transaction is subject to final working capital adjustments.

In  addition  to  the  purchase  and  sale  agreement,  the  Company  also  entered  into  a  contract  manufacturing  agreement  with  Gentell.  Under  the  terms  of  the
agreement, Gentell received inventory, equipment, and tooling to manufacture certain MediHoney® and TCC-EZ® products on behalf of the Company. On
the close date of this transaction, the Company transferred all inventory associated with these products to Gentell and recognized an asset of $11.1 million, as
a form of a deposit for the inventory transferred, which based on the expected timing of inventory purchases, was primarily included within prepaid expenses
and other current assets in the consolidated balance sheet. This deposit will be utilized by the Company on future orders placed to Gentell for such products.
As of December 31, 2022, the Company had a deposit remaining of $8.3 million which is included in prepaid assets and recognized a payable due to Gentell
of $2.7 million, which is included in the consolidated balance sheet within accrued expenses and other current liabilities.

Sale of Extremity Orthopedics Business

On January 4, 2021, the Company completed the sale of its Extremity Orthopedics business to Smith & Nephew USD Limited ("Smith & Nephew"). The
transaction included the sale of the Company's upper and lower Extremity Orthopedics product portfolio, including ankle and shoulder arthroplasty and hand
and wrist product lines. The Company received an aggregate purchase price of $240.0 million from Smith & Nephew and concurrently paid $41.5 million to
the Consortium of Focused Orthopedists, LLC ("CFO") effectively terminating the licensing agreement between Integra and CFO relating to the development
of shoulder arthroplasty products.

F-21

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Assets and liabilities divested consisted of the following as of December 31, 2020 (dollar amounts in thousands):

Prepaid expenses and other current assets
Right of use asset - operating leases and Other assets
Deferred tax assets
Intangible assets, net
Property, plant and equipment, net
Goodwill
Inventories

Total assets held for sale

Other liabilities
Current portion of lease liability - operating leases
Accrued compensation
Deferred tax liabilities
Lease liability - operating leases

Total liabilities held for sale

$

$

$

$

713 
3,186 
6,589 
13,332 
37,893 
47,546 
52,845 
162,104 

336 
539 
1,767 
3,440 
5,669 
11,751 

The divestiture did not represent a strategic shift that had a major effect on the Company's operations and financial statements. Goodwill was allocated to the
assets and liabilities divested using the relative fair value method of the Extremity Orthopedics business to the Company's Tissue Technologies reporting unit.
In connection with the sale, the Company recognized a gain of $41.8 million that is presented in Gain from the sale of business in the consolidated statement
of operations for the year ended December 31, 2021. The Company finalized the net working capital to Smith & Nephew as of December 31, 2021.

The Company also entered into a transition services agreement ("TSA") with Smith & Nephew which requires the Company to provide certain services on
behalf of Smith & Nephew for the duration of the period subsequent to the sale of the business as defined in the TSA. The Company recognized a payable due
to Smith & Nephew of $2.3 million as of December 31, 2022, which is included in the consolidated balance sheet within accrued expenses and other current
liabilities. The TSA includes services such as invoicing and cash collections from customers on behalf of Smith & Nephew. As of December 31, 2022, the
Company has concluded the majority of the transition services agreement, pending final payment.

ACell, Inc. Acquisition

On  January  20,  2021,  the  Company  acquired  ACell,  Inc.  (the  "ACell  Acquisition")  for  an  acquisition  purchase  price  of  $306.9  million  plus  contingent
considerations of up to $100 million, that may be payable upon achieving certain revenue-based performance milestones in 2022, 2023 and 2025. The final
working  capital  adjustments  of  $1.3  million  was  finalized  and  paid  as  of  June  30,  2021.  ACell  was  a  privately-held  company  that  offered  a  portfolio  of
regenerative products for complex wound management, including developing and commercializing products based on MatriStem Urinary Bladder Matrix, a
technology platform derived from porcine urinary bladder extracellular matrix.

Assets Acquired and Liabilities Assumed at Fair Value

The ACell Acquisition has been accounted for using the acquisition method of accounting. This method requires that assets acquired and liabilities assumed in
a business combination are recognized at their fair values as of the acquisition date.

F-22

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The following table summarizes the final fair values of the assets acquired and liabilities assumed at the acquisition date:

Dollars in thousands
Current assets:

Cash
Trade accounts receivable, net
Inventories, net
Prepaid expenses and other current assets

Total current assets

Property, plant and equipment, net
Intangible assets
Goodwill
Right of use asset - operating leases
Deferred tax assets
Other assets
Total assets acquired

Current liabilities:

Accounts payable
Accrued expenses
Current portion of lease liability - operating leases
Total current liabilities

Other long-term liability
Lease liability - operating leases
Deferred tax liability
Contingent consideration
Total liabilities assumed

Net assets acquired

Intangible Assets

Final Valuation

Weighted Average Life

13-14 years

$

$

$

$

$

$

2,726 
16,469 
18,299 
1,498 
38,992 
13,769 
245,000 
94,147 
9,259 
7,465 
148 
408,780 

718 
5,966 
1,673 
8,357 
276 
7,585 
61,724 
23,900 
101,842 

306,938 

The estimated fair value of the developed technology acquired was determined using the multi-period excess earnings method of the income approach, which
estimates value based on the present value of future economic benefits. Some of the more significant assumptions inherent in the development of those asset
valuations include the estimated net cash flows for each year for each product including net revenues, cost of sales, R&D costs, selling and marketing costs,
the  appropriate  discount  rate  to  select  in  order  to  measure  the  risk  inherent  in  each  future  cash  flow  stream,  the  assessment  of  each  asset’s  life  cycle,  and
competitive trends impacting the asset and each cash flow stream.

The Company used a discount rate of 8.5% to arrive at the present value for the acquired intangible assets to reflect the rate of return a market participant
would expect to earn and incremental commercial uncertainty in the cash flow projections. No assurances can be given that the underlying assumptions used
to prepare the discounted cash flow analysis will not change. For these and other reasons, actual results may vary significantly from estimated results.

Goodwill

The Company allocated goodwill related to the ACell acquisition to the Tissue Technologies segment. Goodwill is the excess of the consideration transferred
over the net assets recognized and represents the expected synergies of the combined company and assembled workforce. Goodwill recognized as a result of
this acquisition is non-deductible for income tax purposes.

F-23

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Contingent Consideration

As part of the acquisition, the Company is required to make payments to the former shareholders of ACell up to $100 million based on the achievement of
certain  revenue-based  performance  milestones  in  2022,  2023,  and  2025.  Based  on  revenue  performance  in  2022,  no  payment  will  be  made  for  the  first
performance milestone. The Company used iterations of the Monte Carlo simulation to calculate the fair value of the contingent consideration that considered
the  possible  outcomes  of  scenarios  related  to  each  specific  milestone.  The  Company  estimated  the  fair  value  of  the  contingent  consideration  to  be  $23.9
million at the acquisition date. The Company recorded $3.7 million and $21.8 million in other liabilities as of December 31, 2022 and 2021, respectively, in
the consolidated balance sheets of the Company. The change in the fair value of the contingent obligation was primarily as a result of changes in the timing
and amount of revenue estimates.

The  Company  determined  the  acquisition  date  fair  value  of  contingent  consideration  obligations  using  a  Monte  Carlo  simulation,  as  well  as  significant
unobservable  inputs,  reflecting  the  Company’s  assessment  of  the  assumptions  market  participants  would  use  to  value  these  liabilities.  The  fair  value
measurement is based on significant inputs not observable in the market and thus represents a Level 3 measurement as defined using the fair value concepts in
ASC  820.  The  resultant  most  likely  payouts  are  discounted  using  an  appropriate  effective  annual  interest  rate.  At  each  reporting  date,  the  contingent
consideration obligations is revalued to estimated fair value and changes in fair value will be reflected as income or expense in our consolidated statement of
operations. Changes in the fair value of the contingent considerations may result from changes in discount periods and rates and changes in the timing and
amount of revenue estimates.

Deferred Tax Liabilities

Deferred tax liabilities result from identifiable intangible assets’ fair value adjustments. These adjustments create excess book basis over tax basis which is
tax-effected by the statutory tax rates of applicable jurisdictions.

5. DEBT

Amendment to the Sixth Amended and Restated Senior Credit Agreement

On February 3, 2020, the Company entered into the sixth amendment and restatement (the "February 2020 Amendment") of its Senior Credit Facility (the
"Senior Credit Facility") with a syndicate of lending banks with Bank of America, N.A., as Administrative Agent. The February 2020 Amendment extended
the  maturity  date  to  February  3,  2025.  The  Company  continues  to  have  the  aggregate  principal  amount  of  up  to  approximately  $2.2  billion  available  to  it
through the following facilities: (i) a $877.5 million Term Loan facility, and (ii) a $1.3 billion revolving credit facility, which includes a $60 million sublimit
for the issuance of standby letters of credit and a $60 million sublimit for swingline loans.

The Company’s maximum consolidated total leverage ratio in the financial covenants (as defined in the Senior Credit Facility) is the following:

Fiscal Quarter

September 30, 2022 through June 30, 2023
September 30, 2023 and the last day of each fiscal quarter thereafter

Maximum Consolidated Total Leverage
Ratio

4.50 to 1.00
4.00 to 1.00

Borrowings under the Senior Credit Facility bear interest, at the Company’s option, at a rate equal to the following:

i.

the  Eurodollar  Rate  (as  defined  in  the  amendment  and  restatement)  in  effect  from  time  to  time  plus  the  applicable  rate  (ranging  from  1.00%  to
2.25%), or

ii.

the highest of:

1.

2.

3.

the weighted average overnight Federal funds rate, as published by the Federal Reserve Bank of New York, plus 0.50%

the prime lending rate of Bank of America, N.A. or

the one-month Eurodollar Rate plus 1.00%

The applicable rates are based on the Company’s consolidated total leverage ratio (defined as the ratio of (a) consolidated funded indebtedness as of such date
less cash that is not subject to any restriction on the use or investment thereof to (b) consolidated EBITDA (as defined by the July 2020 amendment), for the
period of four consecutive fiscal quarters ending on such date).

F-24

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The Company will pay an annual commitment fee (ranging from 0.15% to 0.30%), based on the Company's consolidated total leverage ratio, on the amount
available for borrowing under the revolving credit facility.

The Senior Credit Facility is collateralized by substantially all of the assets of the Company’s U.S. subsidiaries, excluding intangible assets. The Senior Credit
Facility  is  subject  to  various  financial  and  negative  covenants  and  at  December  31,  2022,  the  Company  was  in  compliance  with  all  such  covenants.  In
connection with the February 2020 Amendment, the Company capitalized $4.6 million of financing costs in connection with modification of the Senior Credit
Facility and wrote off $1.2 million of previously capitalized financing costs during the first quarter of 2020. In connection with the July 2020 amendment, the
Company expensed $3.3 million of incremental financing costs in connection with the modification of the Senior Credit Facility during the third quarter of
2020.

There was no balance outstanding at December 31, 2022 under the revolving portion of the Senior Credit Facility and as of December 31, 2021, there was
$31.3 million, outstanding under the revolving portion of the Senior Credit Facility at weighted average interest rate of 1.4%. At December 31, 2022 and
2021,  there  was  $771.3  million  and  $843.8  million,  respectively,  outstanding,  under  the  Term  Loan  component  of  the  Senior  Credit  Facility  at  weighted
average interest rate of 5.6% and 1.4%, respectively. At December 31, 2022 and 2021, there was $38.1 million and $45.0 million, respectively, of the Term
Loan component of the Senior Credit Facility was classified as current on the consolidated balance sheets.

The fair value of outstanding borrowings of the Senior Credit Facility's Term Loan components at December 31, 2022 was $800.8 million. This fair values
were determined by using a discounted cash flow model based on current market interest rates available to the Company. These inputs are corroborated by
observable  market  data  for  similar  liabilities  and  therefore  classified  within  Level  2  of  the  fair  value  hierarchy.  Level  2  inputs  represent  inputs  that  are
observable for the asset or liability, either directly or indirectly, and are other than active market observable inputs that reflect unadjusted quoted prices for
identical assets or liabilities

Letters of credit outstanding as of December 31, 2022 and 2021 totaled $1.6 million. There were no amounts drawn as of December 31, 2022.

Contractual repayments of the Term Loan component of the Senior Credit Facility are due as follows:

Year-ended December 31, 2022

Principal Repayment

Dollars in thousands
2023
2024
2025

$
$
$
$

38,125 
67,500 
669,375 
775,000 

Future interest payments on the term loan component of the Senior Credit Facility based on current interest rates are expected to approximate $42.7 million in
2023, $39.1 million in 2024, and $3.6 million in 2025. Interest is calculated on the term loan portion of the Senior Credit Facility based on LIBOR plus the
spread  paid  by  the  Company.  As  the  revolving  credit  facility  and  Securitization  Facility  can  be  repaid  at  any  time,  no  interest  has  been  included  in  the
calculation.

The outstanding balance of the revolving credit component of the Senior Credit Facility is due on February 3, 2025.

Convertible Senior Notes

On February 4, 2020, the Company issued $575.0 million aggregate principal amount of its 0.5% Convertible Senior Notes due 2025 (the "2025 Notes"). The
2025  Notes  will  mature  on  August  15,  2025  and  bear  interest  at  a  rate  of  0.5%  per  annum  payable  semi-annually  in  arrears,  unless  earlier  converted,
repurchased or redeemed in accordance with the terms of the 2025 Notes. The portion of debt proceeds that was classified as equity at the time of the offering
was  $104.5  million.  The  effective  interest  rate  implicit  in  the  liability  component  was  4.2%.  In  connection  with  this  offering,  the  Company  capitalized
$13.2 million of financing fees.

The 2025 Notes are senior, unsecured obligations of the Company, and are convertible into cash and shares of its common stock based on initial conversion
rate,  subject  to  adjustment  of  13.5739  shares  per  $1,000  principal  amounts  of  the  2025  Notes  (which  represents  an  initial  conversion  price  of  $73.67  per
share). The 2025 Notes convert only in the following circumstances: (1) if the closing price of the Company's common stock has been at least 130% of the
conversion price during the period; (2) if the average trading price per $1,000 principal amount of the 2025 Notes is less than or equal to 98% of the average
conversion value of the 2025 Notes during a period as defined in the indenture; (3) at any time on or after February 20, 2023; or (4) if specified corporate
transactions occur. As of December 31, 2022, none of these conditions existed with respect to the 2025 Notes and as a result the 2025 Notes are classified as
long term.

F-25

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

On  December  9,  2020,  the  Company  entered  into  the  First  Supplemental  Indenture  to  the  original  agreement  dated  as  of  February  4,  2020  between  the
Company and Citibank, N.A., as trustee, governing the Company’s outstanding 2025 Notes. The Company irrevocably elected (1) to eliminate the Company’s
option to choose physical settlement on any conversion of the 2025 Notes that occurs on or after the date of the First Supplemental Indenture and (2) with
respect  to  any  Combination  Settlement  for  a  conversion  of  the  2025  Notes,  the  Specified  Dollar  Amount  that  will  be  settled  in  cash  per  $1,000  principal
amount of the 2025 Notes shall be no lower than $1,000.

Holders of the Notes will have the right to require the Company to repurchase for cash all or a portion of their Notes at 100% of their principal amount, plus
any accrued and unpaid interest, upon the occurrence of a fundamental change (as defined in the indenture relating to the Notes). The Company will also be
required to increase the conversion rate for holders who convert their Notes in connection with certain fundamental changes occurring prior to the maturity
date or following delivery by the Company of a notice of redemption.

In connection with the issuance of the 2025 Notes, the Company entered into call transactions and warrant transactions, primarily with affiliates of the initial
purchasers  of  the  2025  Notes  (the  “hedge  participants”).  The  cost  of  the  call  transactions  was  $104.2  million  for  the  2025  Notes.  The  Company  received
$44.5  million  of  proceeds  from  the  warrant  transactions  for  the  2025  Notes.  The  call  transactions  involved  purchasing  call  options  from  the  hedge
participants, and the warrant transactions involved selling call options to the hedge participants with a higher strike price than the purchased call options. The
initial strike price of the call transactions was $73.67, subject to anti-dilution adjustments substantially similar to those in the 2025 Notes. The initial strike
price of the warrant transactions was $113.34 for the 2025 Notes, subject to customary anti-dilution adjustments.

At December 31, 2022, the carrying amount of the liability was $575.0 million. The fair value of the 2025 Notes at December 31, 2022 was $560.5 million.
Factors that the Company considered when estimating the fair value of the 2025 Notes included recent quoted market prices or dealer quote. The level of the
2025 Notes is considered as Level 1.

As a result of the adoption of ASU 2020-06, for both the years ended December 31, 2022 and 2021, the Company recognized only cash interest related to the
contractual interest coupon on the 2025 Notes of $2.9 million.

Securitization Facility

During the fourth quarter of 2018, the Company entered into an accounts receivable securitization facility (the "Securitization Facility") under which accounts
receivable of certain domestic subsidiaries are sold on a non-recourse basis to a special purpose entity (“SPE”), which is a bankruptcy-remote, consolidated
subsidiary of the Company. Accordingly, the assets of the SPE are not available to satisfy the obligations of the Company or any of its subsidiaries. From time
to  time,  the  SPE  may  finance  such  accounts  receivable  with  a  revolving  loan  facility  secured  by  a  pledge  of  such  accounts  receivable.  The  amount  of
outstanding  borrowings  on  the  Securitization  Facility  at  any  one  time  is  limited  to  $150.0  million.  The  Securitization  Facility  Agreement  ("Securitization
Agreement") governing the Securitization Facility contains certain covenants and termination events. An occurrence of an event of default or a termination
event under this Securitization Agreement may give rise to the right of its counterparty to terminate this facility. As of December 31, 2022, the Company was
in compliance with the covenants and none of the termination events had occurred.

On May 28, 2021, the Company entered into an amendment (the "May 2021 Amendment") of the Securitization Facility which extended the maturity date
from December 21, 2021 to May 28, 2024. The May 2021 Amendment does not increase the Company’s total indebtedness.

At  December  31,  2022  and  2021,  the  Company  had  $104.7  million  and  $112.5  million,  of  outstanding  borrowings  under  its  Securitization  Facility  at  a
weighted average interest rate of 5.0% and 1.1%, respectively. The fair value of the outstanding borrowing of the Securitization Facility at December 31, 2022
was  $104.9  million.  These  fair  values  were  determined  by  using  a  discounted  cash  flow  model  based  on  current  market  interest  rates  available  to  the
Company. These inputs are corroborated by observable market data for similar liabilities and therefore classified within Level 2 of the fair value hierarchy.
Level 2 inputs represent inputs that are observable for the asset or liability, either directly or indirectly, and are other than active market observable inputs that
reflect unadjusted quoted prices for identical assets or liabilities.

F-26

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

6. DERIVATIVE INSTRUMENTS

Interest Rate Hedging

The  Company’s  interest  rate  risk  relates  to  U.S.  dollar  denominated  variable  interest  rate  borrowings.  The  Company  uses  interest  rate  swap  derivative
instruments to manage earnings and cash flow exposure resulting from changes in interest rates. These interest rate swaps apply a fixed interest rate on a
portion of the Company's expected LIBOR-indexed floating-rate borrowings.

The Company held the following interest rate swaps as of December 31, 2022 and 2021 (dollar amounts in thousands):

Hedged Item

Notional Amount

Designation Date

Effective Date

Termination Date

December 31, 2022 December 31, 2021

1-month USD LIBOR Loan

1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan
1-month USD LIBOR Loan

— 
150,000 
200,000 
75,000 
75,000 
75,000 
100,000 
100,000 
575,000 
125,000 

300,000 
150,000 
200,000 
75,000 
75,000 
75,000 
100,000 
100,000 
575,000 
125,000 

December 13, 2017
December 13, 2017
December 13, 2017
October 10, 2018
October 10, 2018
October 10, 2018
December 18, 2018
December 18, 2018
December 15, 2020
December 15, 2020

January 1, 2018
July 1, 2019
January 1, 2018
July 1, 2020
July 1, 2020
July 1, 2020
December 30, 2022
December 30, 2022
July 31, 2025
July 1, 2025

December 31, 2022
June 30, 2024
December 31, 2024
June 30, 2025
June 30, 2025
June 30, 2025
December 31, 2027
December 31, 2027
December 31, 2027
December 31, 2027

$

1,475,000 

$

1,775,000 

December 31, 2022

December 31, 2021

Fixed Interest
Rate

Estimated Fair Value

Asset (Liability)

2.201 % $
2.423 %
2.313 %
3.220 %
3.199 %
3.209 %
2.885 %
2.867 %
1.415 %
1.404 %

$

— 
5,012 
8,380 
1,831 
1,905 
1,970 
4,252 
4,153 
23,742 
5,467 

56,712 

$

(5,268)
(5,520)
(7,421)
(5,512)
(5,464)
(5,494)
(6,886)
(6,764)
3,552 
821 

$

(43,956)

The Company has designated these derivative instruments as cash flow hedges. The Company assesses the effectiveness of these derivative instruments and
has recorded the changes in the fair value of the derivative instrument designated as a cash flow hedge as unrealized gains or losses in accumulated other
comprehensive  income  (“AOCI”),  net  of  tax,  until  the  hedged  item  affected  earnings,  at  which  point  any  gain  or  loss  was  reclassified  to  earnings.  If  the
hedged cash flow does not occur, or if it becomes probable that it will not occur, the Company will reclassify the remaining amount of any gain or loss on the
related cash flow hedge recorded in AOCI to interest expense at that time.

Foreign Currency Hedging

From time to time, the Company enters into foreign currency hedge contracts intended to protect the U.S. dollar value of certain forecasted foreign currency
denominated transactions. The Company assesses the effectiveness of the contracts that are designated as hedging instruments. The changes in fair value of
foreign currency cash flow hedges are recorded in AOCI, net of tax. Those amounts are subsequently reclassified to earnings from AOCI as impacted by the
hedged item when the hedged item affects earnings. If the hedged forecasted transaction does not occur, or if it becomes probable that it will not occur, the
Company  will  reclassify  the  amount  of  any  gain  or  loss  on  the  related  cash  flow  hedge  to  earnings  at  that  time.  For  contracts  not  designated  as  hedging
instruments, the changes in fair value of the contracts are recognized in other income, net in the consolidated statements of operation, along with the offsetting
foreign currency gain or loss on the underlying assets or liabilities.

The  success  of  the  Company’s  hedging  program  depends,  in  part,  on  forecasts  of  certain  activity  denominated  in  foreign  currency.  The  Company  may
experience unanticipated currency exchange gains or losses to the extent that there are differences between forecasted and actual activities during periods of
currency volatility. In addition, changes in currency exchange rates related to any unhedged transactions may affect earnings and cash flows.

Cross-Currency Rate Swaps

On October 2, 2017, the Company entered into cross currency swap agreements to convert a notional amount of $300.0 million equivalent to 291.2 million of
Swiss  Francs  ("CHF")  denominated  intercompany  loans  into  U.S.  dollars.  The  CHF-  denominated  intercompany  loans  were  the  result  of  the  purchase  of
intellectual  property  by  a  subsidiary  in  Switzerland  as  part  of  an  acquisition.  On  September  26,  2022,  the  Company  amended  the  CHF-denominated
intercompany loan to extend the termination date to September 2023 and as a result, the Company early terminated the cross-currency swap designated as
cash flow hedge of an intercompany loan with aggregate notional amount of $50.0 million. Simultaneously, the Company entered into a cross-currency swap
agreement to convert a notional amount of CHF 48.5 million equivalent to $49.1 million of this

F-27

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

amended  intercompany  loan  into  U.S.  dollars.  The  loss  recorded  by  the  Company  upon  the  settlement  of  the  swap  was  not  material  for  the  period.  As of
December 31, 2022, $49.1 million of the $300.0 million notional amount remain outstanding.

On  December  21,  2020,  the  Company  entered  into  cross-currency  swap  agreements  to  convert  a  notional  amount  of  $471.6  million  equivalent  to  420.1
million of a CHF-denominated intercompany loan into U.S. dollars. The CHF-denominated intercompany loan was the result of an intra-entity transfer of
certain  intellectual  property  rights  to  a  subsidiary  in  Switzerland  completed  during  the  fourth  quarter  of  2020.  The  intercompany  loan  requires  quarterly
payments  of  CHF  5.8  million  plus  accrued  interest.  As  a  result,  the  aggregate  notional  amount  of  the  related  cross-currency  swaps  will  decrease  by  a
corresponding amount.

The objective of these cross-currency swaps is to reduce volatility of earnings and cash flows associated with changes in the foreign currency exchange rate.
Under the terms of these contracts, which have been designated as cash flow hedges, the Company will make interest payments in Swiss Francs and receive
interest in U.S. dollars. Upon the maturity of these contracts, the Company will pay the principal amount of the loans in Swiss Francs and receive U.S. dollars
from the counterparties.

The Company held the following cross-currency rate swaps as of December 31, 2022 and 2021 (dollar amounts in thousands):

Effective Date

Termination
Date

Fixed Rate

Aggregate Notional Amount

Fair Value Asset (Liability)

December 31, 2022 December 31, 2021

December 31, 2022 December 31, 2021

October 2, 2017

October 2, 2022

December 21, 2020

December 22,
2025

September 28,
2022

September 29,
2023

1.95%

4.52%

3.00%

3.98%

1.95%

5.32%

CHF

$

CHF

$

CHF

$

— 

— 

374,137 

420,001 

48,532 

49,142 

145,598 

150,000 

397,137 

445,821 

— 

— 

— 

(8,283)

(4,241)

(3,528)

41 

— 

$

(7,769) $

(8,242)

Pay CHF

Receive U.S.$

Pay CHF

Receive U.S.$

Pay CHF

Receive U.S.$

Total

rd

On October 3 , 2022, in accordance with the termination date, the Company settled cross-currency swaps designated as cash flow hedges of an intercompany
loan with aggregate notional amounts of $100 million. Based on the closing exchange rates, the gain upon settlement of these swaps was approximately $1.6
million which was offset by the loss on the settlement of the intercompany loan.

On October 4, 2021 in accordance with the termination date, the Company settled a cross-currency swap designated as a cash flow hedge of an intercompany
loan with an aggregate notional amount of $50.0 million. The gain recorded by the Company upon the settlement of the swap was not material for the period.

The cross-currency swaps are carried on the consolidated balance sheet at fair value, and changes in the fair values are recorded as unrealized gains or losses
in AOCI.

Net Investment Hedges

The Company manages certain foreign exchange risks through a variety of strategies, including hedging. The Company is exposed to foreign exchange risk
from its international operations through foreign currency purchases, net investments in foreign subsidiaries, and foreign currency assets and liabilities created
in the normal course of business. On October 1, 2018 ,December 16, 2020 and May 26, 2022, the Company entered into cross-currency swap agreements
designated as net investment hedges to partially offset the effects of foreign currency on foreign subsidiaries.

F-28

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The  Company  held  the  following  cross-currency  rate  swaps  designated  as  net  investment  hedges  as  of  December  31,  2022  and  2021  (dollar  amounts  in
thousands):

Effective Date

Termination
Date

Fixed
Rate

Aggregate Notional Amount

Fair Value
Asset (Liability)

December 31,
2022

December 31,
2021

December 31,
2022

December 31,
2021

Pay EUR

Receive U.S.$

Pay EUR

Receive U.S.$

Pay CHF

Receive USD

Pay CHF

Receive U.S.$

Total

October 3, 2018

September 30,
2023

October 3, 2018

September 30,
2025

December 16,
2020

December 16,
2027

May 26, 2022

December 16,
2028

—%

2.57%

—%

2.19%

—%

1.10%

—%

1.94%

EUR

$

EUR

$

CHF

$

CHF

$

51,760 

60,000 

38,820 

45,000 

— 

— 

288,210 

300,000 

51,760 

60,000 

38,820 

45,000 

222,300 

250,000 

— 

— 

4,713 

2,503 

4,307 

2,147 

— 

(792)

(14,663)

— 

$

(5,643) $

3,858 

On May 26, 2022, the Company early settled cross-currency swaps designated as net investment hedge with an aggregate notional amount of $250 million
equivalent to 222.3 million CHF. The original settlement date was December 16, 2027. As a result of the settlement, the Company recorded a gain of $4.9
million in AOCI. On May 26, 2022, the Company entered into cross-currency swap agreements designated as net investment hedge to replace these swaps
with a notional amount of $300 million equivalent to 288 million CHF.

On  September  30,  2021,  in  accordance  with  the  termination  date,  the  Company  settled  cross-currency  swaps  designated  as  net  investment  hedge  with  an
aggregate notional amount of $52 million equivalent to 44.9 million Euros. As a result of the settlement, the Company recorded a gain of $0.1 million in
AOCI.

The cross-currency swaps were carried on the consolidated balance sheet at fair value and changes in the fair values were recorded as unrealized gains or
losses in AOCI.

Counterparty Credit Risk

The Company manages its concentration of counterparty credit risk on its derivative instruments by limiting acceptable counterparties to a group of major
financial  institutions  with  investment  grade  credit  ratings,  and  by  actively  monitoring  their  credit  ratings  and  outstanding  positions  on  an  ongoing  basis.
Therefore, the Company considers the credit risk of the counterparties to be low. Furthermore, none of the Company’s derivative transactions are subject to
collateral or other security arrangements, and none contain provisions that depend upon the Company’s credit ratings from any credit rating agency.

Fair Value of Derivative Instruments

The Company has classified all of its derivative instruments within Level 2 of the fair value hierarchy because observable inputs are available for substantially
the full term of the derivative instruments. The fair values of the interest rate swaps and cross-currency swaps were developed using a market approach based
on publicly available market yield curves and the terms of the swap. The Company performs ongoing assessments of counterparty credit risk.

F-29

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Effects of Derivative Instruments on Financial Position and Results of Operations

The following table summarizes the fair value for derivatives designated as hedging instruments in the consolidated balance sheets as of December 31, 2022
and 2021:

Dollars in thousands
Location on Balance Sheet 
Derivatives designated as hedges — Assets:
Prepaid expenses and other current assets

(1)
:

Cash Flow Hedges

Cross-currency swap
Interest rate swap
Net Investment Hedges
Cross-currency swap

(2)

Other assets

Cash Flow Hedges
Interest rate swap
Net Investment Hedges
Cross-currency swap

(2)

Total derivatives designated as hedges — Assets

Derivatives designated as hedges — Liabilities
Accrued expenses and other current liabilities

(2)

Cash Flow Hedges
Interest rate swap
Cross-currency swap
Net Investment Hedges
Cross-currency swap

Other liabilities
Cash Flow Hedges
Interest rate swap
Cross-currency swap
Net Investment Hedges
Cross-currency swap

(2)

Total derivatives designated as hedges — Liabilities

Fair Value as of December 31,

2022

2021

$

$

4,497 
16,682 

11,653 

40,030 

3,311 
76,173  $

—  $

3,528 

— 

— 
8,738 

20,608 
32,874 

4,900 
— 

5,120 

4,373 

2,104 
16,497 

18,187 
8,283 

— 

30,143 
4,859 

3,366 
64,838 

(1)

(2)

The Company classifies derivative assets and liabilities as current based on the cash flows expected to be incurred within the following 12 months.

At December 31, 2022 and 2021, the total notional amounts related to the Company’s interest rate swaps were $1.5 billion and $1.8 billion respectively.

F-30

 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The  following  presents  the  effect  of  derivative  instruments  designated  as  cash  flow  hedges  and  net  investment  hedges  on  the  accompanying  consolidated
statement of operations during the years ended December 31, 2022 and 2021:

Dollars in thousands
Year Ended December 31, 2022

Cash Flow Hedges
Interest rate swap
Cross-currency swap
Net Investment Hedges
Cross-currency swap

Year Ended December 31, 2021

Cash Flow Hedges
Interest rate swap
Cross-currency swap
Net Investment Hedges
Cross-currency swap

Balance in AOCI
Beginning of
Year

Amount of
Gain (Loss)
Recognized in
AOCI

Amount of Gain (Loss)
Reclassified from
AOCI into
Earnings

Balance in AOCI
End of Year

Location in
Statements of
Operations

$

$

$

$

(43,956) $
(9,688)

(2,321)
(55,965) $

(93,769) $
(1,073)

(12,291)
(107,133) $

93,308 
8,847 

2,196 
104,351 

27,402 
24,275 

16,515 
68,192 

$

$

$

$

(7,360)
19,430 

6,789 
18,859 

(22,411)
32,890 

6,545 
17,024 

$

$

$

$

56,712 
(20,271) Other income, net

Interest expense

Interest income

(6,914)
29,527 

(43,956)

Interest expense

(9,688) Other income, net

(2,321)
(55,965)

Interest income

For the years ended December 31, 2022 and 2021, the Company recorded a gain of $11.1 million and gain of $23.8 million, respectively, in other income, net
related to change in fair value related to the foreign currency rate translation of the cross-currency swaps, designated as cash flow hedges, to offset the gains
or losses recognized on the intercompany loans.

For the years ended December 31, 2022 and 2021, the Company recorded gains of $8.4 million and $9.1 million, respectively, in other income, net included in
the consolidated statements of operations related to the interest rate differential of the cross-currency swaps designated as cash flow hedges.

The estimated gain that is expected to be reclassified to other income, net from AOCI as of December 31, 2022, for the cross-currency swaps designated as
cash  flow  hedges  within  the  next  twelve  months  is  $4.5  million.  As  of  December  31,  2022,  the  Company  does  not  expect  any  gains  or  losses  will  be
reclassified into earnings as a result of the discontinuance of these cash flow hedges because the original forecasted transaction will not occur.

The estimated gain that is expected to be reclassified to interest income from AOCI as of December 31, 2022 for the cross-currency swaps designated as net
investment hedges, within the next twelve months is $11.7 million.

Derivative Instruments not designated hedges:

During  the  fourth  quarter  of  2020,  the  Company  entered  into  foreign  currency  forward  contracts,  with  a  notional  amount  of  $4.2  million,  to  mitigate  the
foreign exchange risk related to certain intercompany loans denominated in Canadian Dollar ("CAD"). These contracts were settled in third quarter of 2022.

During  the  second  quarter  of  2021,  the  Company  entered  into  a  foreign  currency  swap,  with  a  notional  amount  of  $7.3  million,  to  mitigate  the  risk  from
fluctuations  in  foreign  currency  exchange  rates  associated  with  an  intercompany  loan  denominated  in  JPY.  In  a  foreign  currency  swap  transaction,  the
Company agrees with another party to exchange, at specified intervals, the difference between one currency and another currency at a fixed exchange rate,
generally set at inception, calculated by reference to an agreed upon notional amount. The notional amount of each currency is exchanged at the inception and
termination of the currency swap by each party. The Company subsequently paid down a portion of this swap, bringing the notional amount down to $6.4
million.

The following table summarizes the gains (losses) of derivative instruments not designated as hedges on the condensed consolidated statements of income,
which was included in other income:

F-31

 
 
 
 
 
 
 
 
 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Dollars in thousands

Foreign currency forward contracts
Foreign currency swaps

Total

$

$

December 31,

2022

2021

—  $

1,258 
1,258  $

(174)
629
455 

7. GOODWILL AND OTHER INTANGIBLE ASSETS

Goodwill

The Company tests goodwill for impairment by either performing a qualitative evaluation or a quantitative test.

The  qualitative  evaluation  is  an  assessment  of  factors  including  reporting  unit  specific  operating  results  as  well  as  industry,  market  and  general  economic
conditions, to determine whether it is more likely than not that the fair values of a reporting unit is less than its carrying amount, including goodwill. The
Company  may  elect  to  bypass  the  qualitative  assessment  for  its  three  reporting  units  and  perform  a  quantitative  test.  The  assumptions  used  in  evaluating
goodwill for impairment are subject to change and are tracked against historical results by management.

The quantitative test estimates the fair value of the three reporting units using a discounted cash flow model, which incorporates significant estimates and
assumptions  made  by  management  which,  by  their  nature,  are  characterized  by  uncertainty.  Inputs  used  to  fair  value  the  Company's  reporting  units  are
considered  inputs  of  the  fair  value  hierarchy.  For  Level  3  measurements,  significant  increases  or  decreases  in  long-term  growth  rates  or  discount  rates  in
isolation or in combination could result in a significantly lower or higher fair value measurement. The key assumptions impacting the valuation included the
following:

•

•

•

The reporting unit's financial projections, which are based on management's assessment of regional and macroeconomic variables, industry trends
and market opportunities, and the Company's strategic objectives and future growth plans.

The  projected  terminal  value  for  the  reporting  unit,  which  represents  the  present  value  of  projected  cash  flows  beyond  the  last  period  in  the
discounted cash flow analysis. The terminal value reflects the Company's assumptions related to long-term growth rates and profitability, which are
based on several factors, including local and macroeconomic variables, market opportunities, and future growth plans.

The discount rate used to measure the present value of the projected future cash flows is set using a weighted-average cost of capital method that
considers  market  and  industry  data  as  well  as  the  Company's  specific  risk  factors  that  are  likely  to  be  considered  by  a  market  participant.  The
weighted-average cost of capital is the Company's estimate of the overall after-tax rate of return required by equity and debt holders of a business
enterprise.

During  the  third  quarter  of  2022,  the  Company  elected  to  perform  a  qualitative  analysis  for  its  three  reporting  units.  The  Company  determined,  after
performing the qualitative analysis, that there was no evidence that it is more likely than not that the fair value was less that the carrying amounts, therefore, it
was not necessary to perform a quantitative impairment test.

Changes in the carrying amount of goodwill in 2022 and 2021 were as follows:

Dollars in thousands

Goodwill at January 1, 2021
ACell Acquisition
Foreign currency translation
Balance at December 31, 2021
Sale of non-core traditional wound care business
SIA Acquisition
Foreign currency translation

Balance at December 31, 2022

Codman Specialty
Surgical

 Tissue
Technologies

Total

$

$

$

671,975  $

260,392  $

932,367 

— 
(8,547)
663,428  $
— 
— 
(7,209)
656,219  $

94,147 
(4,509)
350,030  $
(5,019)
41,855 
(4,204)
382,662  $

94,147 
(13,056)
1,013,458 
(5,019)
41,855 
(11,413)
1,038,881 

F-32

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Other Intangible Assets

The components of the Company's identifiable intangible assets were as follows:

Dollars in thousands
Completed technology
Customer relationships
Trademarks/brand names
Codman trade name
Supplier relationships
All other

Dollars in thousands
Completed technology
Customer relationships
Trademarks/brand names
Codman trade name
Supplier relationships
All other

Weighted
Average
Life

18 years $
12 years
28 years
Indefinite
30 years
11 years

$

Weighted
Average
Life

December 31, 2022

Cost
1,204,325  $
193,081 
97,265 
166,693 
30,211 
5,957 
1,697,532  $

Accumulated
Amortization

(370,968) $
(144,040)
(34,674)
— 
(17,170)
(4,071)
(570,923) $

Net

833,357 
49,041 
62,591 
166,693 
13,041 
1,886 
1,126,609 

December 31, 2021

Cost
1,132,954  $
211,344 
98,367 
167,758 
30,211 
6,258 
1,646,892  $

Accumulated
Amortization

(307,013) $
(142,755)
(31,468)
— 
(16,192)
(3,891)
(501,319) $

Net

825,94
68,58
66,89
167,75
14,01
2,36
1,145,57

18 years $
12 years
28 years
Indefinite
30 years
11 years

$

Intangible Assets with Indefinite Lives

The Company tests intangible assets with indefinite lives for impairment annually in the third quarter in accordance with ASC Topic 350. Additionally, the
Company may perform interim tests if an event occurs or circumstances change that could potentially reduce the fair value of a indefinite lived intangible
asset  below  its  carrying  amount.  The  Company  tests  for  impairment  by  either  performing  a  qualitative  evaluation  or  a  quantitative  test.  The  qualitative
evaluation is an assessment of factors, including specific operating results as well as industry, market and general economic conditions, to determine whether
it  is  more  likely  than  not  that  the  fair  values  of  the  intangible  asset  is  less  than  its  carrying  amount.  The  Company  may  elect  to  bypass  this  qualitative
evaluation and perform a quantitative test.

During the third quarter of 2022, the Company elected to perform a qualitative analysis for its intangible asset with indefinite lives. The Company determined,
after  performing  the  qualitative  analysis,  that  there  was  no  evidence  that  it  is  more  likely  than  not  that  the  fair  value  was  less  that  the  carrying  amounts,
therefore, it was not necessary to perform a quantitative impairment test.

Product rights and other definite-lived intangible assets are tested periodically for impairment in accordance with ASC Topic 360 when events or changes in
circumstances indicate that an asset's carrying value may not be recoverable. The impairment testing involves comparing the carrying amount of the asset or
asset  group  to  the  forecasted  undiscounted  future  cash  flows.  In  the  event  the  carrying  value  of  the  asset  exceeds  the  undiscounted  future  cash  flows,  the
carrying value is considered not recoverable and impairment exists. An impairment loss is measured as the excess of the asset's carrying value over its fair
value, calculated using discounted future cash flows. The computed impairment loss is recognized in the period that the impairment occurs.

Amortization expense (including amounts reported in cost of product revenues) for the years ended December 31, 2022, 2021 and 2020 was $78.3 million,
$83.3 million and $74.5 million, respectively.

F-33

 
 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Annual amortization expense is expected to approximate $82.3 million in 2023, $81.7 million in 2024, $81.7 million in 2025, $81.5 million in 2026, $79.6
million  in  2027  and  $551.6  million  thereafter.  Amortization  of  product  technology  based  intangible  assets  totaled  $64.4  million,  $66.5  million  and  $46.7
million for the years ended December 31, 2022, 2021 and 2020, respectively, and is presented by the Company within cost of goods sold.

8. TREASURY STOCK

As of December 31, 2022 and 2021, there were 6.8 million and 4.9 million shares of treasury stock outstanding with a cost of $362.9 million and $234.4
million, respectively, at a weighted average cost per share of $53.18 and $47.86, respectively.

On January 26, 2023, the Company entered into a $150 million accelerated share repurchase ("2023 ASR") and received 2.1 million shares of the Company
common  stock  at  inception  of  the  2023  ASR,  which  represented  approximately  80%  of  the  expected  total  shares  of  under  the  2023  SAR.  The  remaining
repurchase transactions are expected to be completed in the first half of 2023.

On April 26 2022, the Board of Directors authorized the Company to repurchase up to $225 million of the Company’s common stock. The program allows the
Company  to  repurchase  its  shares  opportunistically  from  time  to  time.  The  repurchase  authorization  expires  in  December  2024.  This  stock  repurchase
authorization replaces the previous $225 million stock repurchase authorization, of which $100 million remained authorized at the time of its replacement,
and which was otherwise set to expire on December 31, 2022. Purchases may be affected through one or more open market transactions, privately negotiated
transactions, transactions structured through investment banking institutions, or a combination of the foregoing.

On January 12, 2022, the Company entered into a $125 million accelerated share repurchase ("2022 ASR") and received 1.48 million shares of Company
common stock at inception of the 2022 ASR, which represented approximately 80% of the expected total shares under the 2022 ASR. In March 24, 2022, the
early exercise provision was exercised by the 2022 ASR counterparty. Upon settlement on March 24, 2022, the Company received an additional 0.46 million
shares determined using the volume-weighted average price of the Company's common stock during the term of the 2022 ASR.

For the year ended December 31, 2021, there were no repurchases of the Company’s common stock as part of the share repurchase authorization.

On August 16, 2022, the Inflation Reduction Act of 2022 (the “Act”) was signed into law. The Act implements a new excise tax of 1% on the net share
repurchases made by the company effective for share repurchases performed January 1, 2023, or after.

9. STOCK-BASED COMPENSATION

Stock-based compensation expense - all related to employees and members of the Board of Directors - recognized under the authoritative guidance was as
follows:

Dollars in thousands
Cost of goods sold
Research and development
Selling, general and administrative
Total stock-based compensation expense
Total estimated tax benefit related to stock-based compensation expense

Net effect on net income

EMPLOYEE STOCK PURCHASE PLAN

Years Ended December 31,

2022

2021

2020

549 
1,739 
25,437  $
27,725 
10,574 
17,151  $

470 
1,644 
34,096  $
36,210 
13,804 
22,406  $

344 
1,471 
17,776 
19,591 
6,221 
13,370 

$

$

The purpose of the Employee Stock Purchase Plan (the “ESPP”) is to provide eligible employees of the Company with the opportunity to acquire shares of
common  stock  at  periodic  intervals  by  means  of  accumulated  payroll  deductions.  The  ESPP  is  a  non-compensatory  plan.  Under  the  ESPP,  a  total  of  3.0
million shares of common stock are reserved for issuance. These shares will be made available either from the Company’s authorized but unissued shares of
common stock or from shares of common stock reacquired by the Company as treasury stock. At December 31, 2022, 2.0 million shares remain available for
purchase under the ESPP. During the years ended December 31, 2022, 2021 and 2020, the Company issued 20,780 shares, 16,948 shares and 18,284 shares
under the ESPP for $1.1 million, $1.1 million and $1.1 million, respectively.

F-34

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

EQUITY AWARD PLANS

As of December 31, 2022, the Company had stock options, restricted stock awards, performance stock awards, contract stock awards and restricted stock unit
awards  outstanding  under  the  Integra  LifeSciences  Holdings  Corporation  Fifth  Amended  and  Restated  2003  Equity  Incentive  Plan  (the  “2003  Plan”).  The
2000 and 2001 Equity Incentive Plans were terminated as of February 19, 2021, and no further awards may be issued under the plans.

In May 2010 and May 2017, the stockholders of the Company approved amendments to the 2003 Plan to increase by 3.5 million and 1.7 million, respectively,
the number of shares of common stock that may be issued under the 2003 Plan. The Company has reserved 4.0 million shares under each of the 2000 Plan and
the  2001  Plan,  and  14.7  million  shares  under  the  2003  Plan.  The  Plans  permit  the  Company  to  grant  incentive  and  non-qualified  stock  options,  stock
appreciation  rights,  restricted  stock,  contract  stock,  performance  stock,  or  dividend  equivalent  rights  to  designated  directors,  officers,  employees  and
associates of the Company.

Stock  options  issued  under  the  2003  Plan  became  exercisable  over  specified  periods,  generally  within  four  years  from  the  date  of  grant  for  officers  and
employees, and within one year from the date of the grant for members of the Board of Directors. The awards generally expire eight years from the grant date
for  employees  and  from  six  to  ten  for  directors  and  certain  executive  officers,  except  in  certain  instances  that  result  in  accelerated  vesting  due  to  death,
disability,  retirement  age  or  change  in  control  provisions  within  their  grant  agreements.  Restricted  stock  issued  under  the  2003  Plan  vests  ratably  over
specified  periods,  generally  three  years  after  the  date  of  grant.  The  vesting  of  performance  stock  issued  under  the  2003  Plan  is  subject  to  service  and
performance conditions.

Stock Options

The Company values stock option grants using the binomial distribution model. Management believes that the binomial distribution model is preferable to the
Black-Scholes  model  because  it  is  a  more  flexible  model  that  gives  consideration  to  the  impact  of  non-transferability  and  vesting  provisions  in  valuing
employee stock options.

In determining the value of stock options granted, the Company considered that it has never paid cash dividends and does not currently intend to pay cash
dividends, and thus has assumed a 0% dividend yield. Expected volatilities are based on the historical volatility of the Company’s stock price. The expected
life of stock options is estimated based on historical data on exercise of stock options, post-vesting forfeitures and other factors to estimate the expected term
of the stock options granted. The risk-free interest rates are derived from the U.S. Treasury yield curve in effect on the date of grant for instruments with a
remaining term similar to the expected life of the options. The Company accounts for forfeitures as they occur.

The following weighted-average assumptions were used in the calculation of fair value:

Dividend yield
Expected volatility
Risk free interest rate
Expected life of option from grant date

Weighted average grant date fair value of options granted

The following table summarizes the Company’s stock option activity.

Stock Options
Outstanding at January 1, 2022
Granted
Exercised
Forfeited or Expired
Outstanding at December 31, 2022
Exercisable at December 31, 2022

Years Ended December 31,

2022
0%
30%
2.01%
7 years

$23.15

2021
0%
29%
1.30%
7 years

$22.59

2020
0%
27%
0.89%
7 years

$13.03

Shares

(In thousands)

Weighted Average
Exercise Price

Weighted Average
Contractual Term in
Years

Aggregate Intrinsic
Value

(In thousands)

1,225  $
146 
(155)
(14)
1,202  $
871  $

45.11 
65.11 
28.32 
50.68 
49.63 
45.82 

4.30
— 
— 
— 
4.14 $
3.30 $

$26,970
— 
— 
— 
10,772 
9,635 

F-35

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The Company recognized $3.5 million, $5.0 million and $3.2 million in expense related to stock options during the years ended December 31, 2022, 2021 and
2020, respectively. The intrinsic value of options exercised for the years ended December 31, 2022, 2021 and 2020 were $4.0 million, $11.1 million and $8.7
million, respectively. Cash received from option exercises and employee stock purchase plan was $5.5 million, $6.8 million and $5.2 million, for the years
ended December 31, 2022, 2021 and 2020, respectively. The realized tax benefit from options exercised were $0.6 million, $2.2 million and $1.7 million for
the years ended December 31, 2022, 2021 and 2020, respectively.

As of December 31, 2022, there was approximately $3.5 million of total unrecognized compensation costs related to unvested stock options. These costs are
expected to be recognized over a weighted-average period of approximately two years.

Awards of Restricted Stock, Performance Stock and Contract Stock

The following table summarizes the Company’s awards of restricted stock, performance stock and contract stock for the year ended December 31, 2022.

Unvested, January 1, 2022
Granted
Adjustments for performance achievement related to award target
Cancellations
Released

Unvested, December 31, 2022

Restricted Stock Awards

Performance Stock and Contract Stock Awards

Weighted Average
Grant Date Fair Value
Per Share

Shares

(In thousands)

Shares

(In thousands)

Weighted Average
Grant Date Fair Value
Per Share

422  $
334 
— 
(34)
(239)
483  $

58.78 
62.88 
— 
62.29 
58.27 
61.63 

442 
245 
(18)
(10)
(252)
407 

60.62 
62.89 
60.76 
59.88 
59.38 
62.88 

The Company recognized $24.3 million, $31.2 million and $16.4 million in expense related to such awards during the years ended December 31, 2022, 2021
and 2020, respectively. The total fair market value of shares vested and released in 2022, 2021 and 2020 was $65.0 million, $15.7 million and $17.3 million,
respectively. Vested awards include shares that have been fully earned but had not been delivered as of December 31, 2022.

Performance  stock  awards  have  performance  features  associated  with  them.  Performance  stock,  restricted  stock  and  contract  stock  awards  generally  have
requisite service periods of three years. The fair value of these awards is being expensed on a straight-line basis over the vesting period. As of December 31,
2022, there were 129,399 performance stock units ("PSU's") subject to vest and be released based on 2022 performance achievement.

As of December 31, 2022, there was approximately $29.7 million of total unrecognized compensation costs related to unvested restricted stock, performance
stock and contract stock awards. These costs are expected to be recognized over a weighted-average period of approximately two years.

At December 31, 2022, there were approximately 3.1 million shares available for grant under the 2003 Plan.

The Company capitalized into inventory, share based compensation costs of $0.6 million, $0.5 million and $0.4 million for the years ended December 31,
2022, 2021 and 2020, respectively. Such share-based compensation was recognized as cost of goods sold when related inventory was sold.

F-36

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

10. RETIREMENT BENEFIT PLANS

DEFINED BENEFIT PLANS

The Company has various defined benefit plans which covers certain employees in France, Japan, Germany and Switzerland.

Net periodic benefit costs for the Company’s defined benefit pension plans for the years ended December 31, 2022 and 2021 included the following (amounts
in thousands):

Service cost
Interest cost
Expected return on plan assets
Amortization of prior service cost (credit)
Recognized actuarial losses
Settlements

Net period benefit cost

Year ended December 31,

2022

2021

$

$

2,419 
194 
(1,381)
(326)
9 
— 
915 

$

$

2,741 
100 
(893)
(281)
186 
51 
1,904 

The following weighted average assumptions were used to develop net periodic pension benefit costs and the actuarial present values of projected pension
benefit obligations for the years ended December 31, 2022 and 2021, respectively:

Discount rate
Expected return on plan assets
Rate of compensation increase
Interest crediting rate for cash balance plans

As of December 31,

2022

2021

2.44 %
3.61 %
1.97 %
1.00 %

0.37 %
3.59 %
2.10 %
1.00 %

The  Company’s  discount  rates  are  determined  by  considering  current  yield  curves  representing  high  quality,  long-term  fixed  income  instruments.  The
resulting  discount  rates  are  consistent  with  the  duration  of  plan  liabilities.  In  2022  and  2021,  the  discount  rates  were  prescribed  as  the  current  yield  on
corporate bonds with an average rating of AA or AAA of equivalent currency and term to the liabilities. The expected returns on plan assets represent the
average rate of return expected to be earned on plan assets over the period the benefits included in the benefit obligation are to be paid. In developing the
expected rates of return, the Company considers returns of historical market data as well as actual returns on the plan assets. Using this reference information,
the long-term return expectations for each asset category are developed according to the allocation among those investment categories.

The assessment is determined using projections from external financial sources, long-term historical averages, actual returns by asset class and the various
asset class allocations by market.

F-37

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The following sets forth the change in projected benefit obligations and the change in plan assets for the years ended December 31, 2022 and 2021 and a
reconciliation of the funded status at December 31, 2022 and 2021, respectively (amounts in thousands):

Change In Projected Benefit Obligations

Projected benefit obligations, beginning of year
Interest cost
Service cost
Actuarial (gain) loss
Plan amendments
Plan settlements
Employee contribution
Premiums paid
Benefit payment
Effect of foreign currency exchange rates

Projected benefit obligations, end of year

Change In Plan Assets

Plan assets at fair value, beginning of year
Actual return on plan assets
Employer contributions
Employee contributions
Plan settlements
Benefits paid
Premiums paid
Effect of foreign currency exchange rates

Plan assets at fair value, end of year

Reconciliation Of Funded Status

Fair value of plan assets
Benefit obligations

Unfunded benefit obligations

Year ended December 31,

2022

2021

65,184 
194 
2,419 
(14,822)
(390)
(20)
999 
(391)
(999)
(1,810)
50,364 

$

$

Year ended December 31,

2022

2021

39,914 
(2,863)
2,356 
999 
— 
(998)
(391)
(964)
38,053 

$

$

Year ended December 31,

2022

2021

38,053 
50,364 
12,311 

$

$

72,869 
100 
2,741 
(5,044)
(586)
(655)
917 
(373)
(2,128)
(2,657)
65,184 

37,825 
3,371 
2,254 
917 
(633)
(2,128)
(373)
(1,319)
39,914 

39,914 
65,184 
25,270 

$

$

$

$

$

$

The unfunded benefit obligations are included in other liabilities in the consolidated balance sheets at December 31, 2022 and 2021, respectively.

During  the  periods  ended  December  31,  2022  and  2021,  the  Company  had  a  net  gain  of  $7.4  million  and  $7.0  million,  respectively,  recognized  within
accumulated other comprehensive loss that has not been recognized as a component of net periodic benefit cost. The gain recognized during the period ended
December 31, 2021, is primarily attributed to a change in the discount rate used to estimate the projected benefit obligation for defined benefit plans which
cover certain employees in Switzerland. The combined accumulated benefit obligations for the defined benefit plans was $46.4 million and $60.3 million as
of December 31, 2022 and 2021, respectively.

Unrecognized gains and losses are amortized over the average remaining future service for each plan. For plans with no active employees, they are amortized
over the average life expectancy. The amortization of gains and losses is determined by using a 10% corridor of the greater of the market value of assets or the
accumulated benefit obligation. Total unamortized gains and losses in excess of the corridor are amortized over the average remaining future service.

Prior  service  costs/benefits  for  the  pension  plans  are  amortized  over  the  average  remaining  future  service  of  plan  participants  at  the  time  of  the  plan
amendment.

F-38

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The net plan assets of the pension plans are invested in common trusts. Common trusts are classified as Level 2 in fair value hierarchy. The fair value of
common trusts is valued at net asset value based on the fair values of the underlying investments of the trusts as determined by the sponsor of the trusts. The
investment strategy of the Company's defined benefit plans is both to meet the liabilities of the plans as they fall due and to maximize the return on invested
assets within appropriate risk profile.

The benefit plans in France and Germany had no assets at December 31, 2022.

As of December 31, 2022, no plan assets are expected to be returned to the Company in the next twelve months.

The following table is the summary of expected future benefit payments (in thousands):

2023
2024
2025
2026
2027
Next five years

$
$
$
$
$
$

2,211 
2,045 
2,050 
1,929 
1,868 
11,068 

As of December 31, 2022, contributions expected to be paid to the plan in 2022 is $2.6 million.

DEFINED CONTRIBUTION PLANS

The Company also has various defined contribution savings plans that cover substantially all employees in the United States, Belgium, Canada, France, Japan,
Netherlands, the U.K. and Puerto Rico. The Company matches a certain percentage of each employee’s contributions as per the provisions of the plans. Total
contributions  by  the  Company  to  the  plans  were  $9.8  million,  $8.8  million  and  $6.7  million  for  the  years  ended  December  31,  2022,  2021  and  2020,
respectively.

DEFERRED COMPENSATION PLAN

The Company maintains a Deferred Compensation Plan in which certain employees of the Company may defer the payment and taxation of up to 75% of
their base salary and up to 100% of bonus amounts and other eligible cash compensation.

This deferred compensation is invested in funds offered under this plan and is valued based on Level 1 measurements in the fair value hierarchy. Assets of the
Company's deferred compensation plan are included in Other current assets and recorded at fair value based on their quoted market prices. The fair value of
these assets at December 31, 2022 and 2021 was $4.7 million and $3.8 million. Offsetting liabilities relating to the deferred compensation plan are included in
Other liabilities.

11. LEASES AND RELATED PARTY LEASES

The Company leases administrative, manufacturing, research and distribution facilities and vehicles through operating lease agreements. The Company has no
finance leases as of December 31, 2022. Many of the Company's leases include both lease (e.g., fixed payments including rent) and non-lease components
(e.g., common-area or other maintenance costs). For vehicles, the Company has elected the practical expedient to group lease and non-lease components. 

Most facility leases include one or more options to renew. The exercise of lease renewal options is typically at the Company's sole discretion, therefore, the
majority  of  renewals  to  extend  the  lease  terms  are  not  included  in  the  ROU  assets  and  lease  liabilities  as  they  are  not  reasonably  certain  of  exercise.  The
Company regularly evaluates renewal options and when they are reasonably certain of exercise, the renewal period is included in the lease term.

As  most  of  the  Company's  leases  do  not  provide  an  implicit  rate,  the  Company  uses  a  collateralized  incremental  borrowing  rate  based  on  the  information
available at the lease commencement date in determining the present value of the lease payments.

Total  operating  lease  expense  for  the  year  ended  December  31,  2022  and  2021,  was  $22.6  million  and  $20.3  million,  respectively,  which  includes  $0.3
million, in related party operating lease expense.

F-39

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Supplemental balance sheet information related to operating leases at December 31, 2022 were as follows:

ROU assets

Current lease liabilities
Non-current lease liabilities

Total lease liabilities

Weighted average remaining lease term (in years):

Leased facilities
Leased vehicles

Weighted average discount rate:

Leased facilities
Leased vehicles

$

$

December 31, 2022

December 31, 2021

(In thousands, except lease term and discount rate)

148,284 

$

14,624 
157,420 
172,044 

$

16.9 years
2.0 years

5.4 %
2.7 %

84,543 

14,775 
90,329 
105,104 

10.4 years
2.1 years

5.1 %
2.6 %

Supplemental cash flow information related to leases was as follows:

Cash paid for amounts included in the measurement of lease liabilities:

Operating cash flows from operating leases

ROU assets obtained in exchange for lease liabilities:

Operating leases

Future minimum lease payments under operating leases at December 31, 2022 were as follows:

December 31, 2022

December 31, 2021

(In thousands)

$

17,442  $

15,077 

72,169 

12,610 

2023
2024
2025
2026
2027
Thereafter

Total minimum lease payments
Less: Imputed interest
Total lease liabilities
Less: Current lease liabilities
Long-term lease liabilities

Related Parties

Third Parties

(In thousands)

Total

296 
296 
296 
296 
296 
542 
2,022  $

$

20,024 
20,869 
19,198 
16,830 
15,886 
164,622 
257,429  $

$

20,320 
21,165 
19,494 
17,126 
16,182 
165,164 
259,451 

87,407 
172,044 
14,624 
157,420 

There were no future minimum lease payments under finance leases at December 31, 2022.

F-40

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Related Party Leases

The Company leases its manufacturing facility in Plainsboro, New Jersey, from a general partnership that is 50% owned by a corporation whose stockholders
are trusts, whose beneficiaries include family members of the Company’s principal stockholder and former director. The term of the current lease agreement is
through October 31, 2029 at an annual rate of approximately $0.3 million per year. The current lease agreement also provides (i) a 5-year renewal option for
the  Company  to  extend  the  lease  from  November  1,  2029  through  October  31,  2034  at  the  fair  market  rental  rate  of  the  premises,  and  (ii)  another  5-year
renewal option to extend the lease from November 1, 2034 through October 31, 2039 at the fair market rental rate of the premises.

12. INCOME TAXES

Income before income taxes consisted of the following:

Dollars in thousands
United States operations
Foreign operations

Total

Years Ended December 31,

2022

2021

2020

$

$

92,642  $
121,252 
213,894  $

91,150  $
123,527 
214,677  $

15,082 
78,438 
93,520 

A reconciliation of the U.S. Federal statutory rate to the Company’s effective tax rate is as follows:

Federal statutory rate
Increase (decrease) in income taxes resulting from:
   State income taxes, net of federal tax benefit
   Foreign operations

 Excess tax benefits from stock compensation

   Intercompany profit in inventory
   Nondeductible facilitative costs
   Contingent Consideration
   Research and development credit
   Return to provision
   Global intangible low-taxed income ("GILTI")
   Nondeductible executive compensation
   Fair market value step up on intra-entity transfer of intellectual property
   Gain from sale of business - book to tax differences
   Other

Effective tax rate

Years Ended December 31,

2022

2021

2020

21.0 %

0.1 %
(3.9)%
(2.4)%
0.3 %
0.2 %
(2.0)%
(1.4)%
(0.5)%
2.8 %
1.8 %
— %
— %
(0.4)%
15.6 %

21.0 %

1.9 %
(4.0)%
(1.2)%
(0.2)%
0.3 %
(0.2)%
(1.2)%
(0.7)%
0.7 %
0.9 %
— %
3.9 %
— %
21.2 %

21.0 %

1.2 %
(7.9)%
(1.0)%
1.2 %
1.1 %
0.2 %
(1.6)%
(2.3)%
2.5 %
2.4 %
(63.3)%
2.8 %
0.5 %
(43.2)%

Our effective tax rate was 15.6% and 21.2% of income before income taxes for the years ended December 31, 2022 and December 31, 2021, respectively. In
2022, the Company’s lower effective tax rate was driven by a $5.1 million income tax benefit related to stock compensation and a $2.4 million income tax
benefit related to the filing of amended federal and state returns for prior years. In 2021, the Company's higher effective tax rate was driven in part by an
$8.5 million income tax expense for nondeductible goodwill related to the sale of the Extremity Orthopedics business, offset by a $3.1 million income tax
benefit  related  to  excess  tax  benefits  from  stock  compensation.  In  2020,  the  Company’s  lower  worldwide  effective  tax  rate  was  primarily  driven  by  an
$59.2  million  income  tax  benefit  on  an  intra-entity  transfer  of  certain  intellectual  property,  substantially  completed  during  the  fourth  quarter  in  2020.
Excluding this transaction, the effective worldwide tax rate for 2020 was 20.2%.

F-41

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

In December 2020, the Company completed an intra-entity transfer of certain intellectual property rights to one of its subsidiaries in Switzerland. While the
transfer did not result in a taxable gain, the Company’s Swiss subsidiary received a step-up in tax basis based on the fair value of the transferred intellectual
property rights. The Company determined the fair value using a discounted cash flow model based on expectations of revenue growth rates, royalty rates,
discount  rates,  and  useful  lives  of  the  intellectual  property.  The  Company  recorded  a  $59.2  million  deferred  tax  benefit  in  Switzerland  related  to  the
amortizable tax basis in the transferred intellectual property.

During 2022, the Company’s foreign operations generated a $0.4 million increase in income tax expense when compared to the same period in 2021, because
of geographic and business mix of taxable earnings and losses, among other factors. The 2022 foreign effective tax rate is 15.9%, compared to 15.2% in 2021.
The Company’s foreign tax rate is primarily based upon statutory rates.

During  2021,  the  Company’s  foreign  operations  generated  a  $63.6  million  increase  in  income  tax  expense  when  compared  to  the  same  period  in  2020,
because of the intra-entity transfer of certain intellectual property in 2020, geographic and business mix of taxable earnings and losses, among other factors.
The 2021 foreign effective tax rate is 15.2%, compared to (57.1)% in 2020. The Company’s foreign tax rate is primarily based upon statutory rates and is also
impacted by the intra-entity transfer of certain intellectual property as described above for 2020.

Changes  to  income  tax  laws  and  regulations,  in  any  of  the  tax  jurisdictions  in  which  the  Company  operates,  could  impact  the  effective  tax  rate.  Various
governments, both U.S. and non-U.S., are increasingly focused on tax reform and revenue-raising legislation. On August 16, 2022, the Inflation Reduction
Act of 2022 (the “Act”) was signed into law, the company does not expect the law to have a material impact on the company’s effective tax rate. Further,
legislation in foreign jurisdictions may be enacted, in response to the base erosion and profit-sharing (BEPS) project begun by the Organization for Economic
Cooperation and Development (OECD). The OECD recently finalized major reform of the international tax system with respect to implementing a global
minimum tax rate. Such changes in U.S. and Non-U.S. jurisdictions could have an adverse effect on the Company’s effective tax rate.

The provision for income taxes consisted of the following:

Dollars in thousands
Current:
   Federal
   State
   Foreign
Total current
Deferred:
   Federal
   State
   Foreign
Total deferred

Provision for income taxes

Years Ended December 31,

2022

2021

2020

$

$

$
$

24,201  $
3,835 
9,893 
37,929  $

(11,591)
(2,316)
9,322 
(4,585) $
33,344  $

31,938  $
11,377 
5,042 
48,357  $

(12,830)
(3,688)
13,763 
(2,755) $
45,602  $

6,184 
5,029 
12,553 
23,766 

(5,079)
(1,760)
(57,299)
(64,138)
(40,372)

F-42

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The  income  tax  effects  of  significant  temporary  differences  that  give  rise  to  deferred  tax  assets  and  liabilities,  shown  before  jurisdictional  netting,  are
presented below:

Dollars in thousands
Assets:
   Doubtful accounts
   Inventory related items
   Tax credits
   Accrued vacation
   Accrued bonus
   Stock compensation
   Deferred revenue
   Net operating loss carryforwards

Capitalization of research and development expenses

   Unrealized foreign exchange gain
   Charitable contributions carryforward
   Leases and Other
   Total deferred tax assets
   Less valuation allowance

   Deferred tax assets after valuation allowance
Liabilities:
   Intangible and fixed assets
   Unrealized foreign exchange loss
   Leases and Other
   Total deferred tax liabilities

Total net deferred tax assets (liabilities)

December 31,

2022

2021

$

$

$
$

2,261  $

31,950 
13,084 
2,175 
4,944 
10,175 
2,130 
30,707 
51,542 
6,228 
180 
39,788 
195,164 
(9,651)
185,513  $

(166,891)
(12,991)
(22,975)
(202,857) $
(17,344) $

2,029 
31,841 
13,319 
3,042 
7,415 
13,955 
1,742 
26,198 
36,770 
12,849 
206 
41,371 
190,737 
(9,767)
180,970 

(152,150)
— 
(17,658)
(169,808)
11,162 

The 2017 U.S. Tax Cuts and Jobs Act contained a provision which requires, for tax purposes, the capitalization and amortization of research and development
expenses;  effective  for  years  beginning  after  December  31,  2021.  The  Company’s  deferred  tax  assets  increased  by  $20.2  million  within  the  table  above,
related to the 2017 Tax Act.

At December 31, 2022, the Company had net operating loss carryforwards of $79.5 million for federal income tax purposes, $75.5 million for foreign income
tax purposes and $37.9 million for state income tax purposes to offset future taxable income. The majority of the federal net operating loss carryforwards
expire  through  2037,  while  $18.6  million  have  an  indefinite  carry  forward  period.  For  foreign  net  operating  loss  carryforwards,  $59.1  million  will  expire
through 2028, while the remaining $16.4 million have an indefinite carry forward period. The state net operating loss carryforwards expire through 2036.

The valuation allowance relates to deferred tax assets for certain items that will be deductible for income tax purposes under very limited circumstances and
for  which  the  Company  believes  it  will  not  satisfy  the  more  likely  than  not  threshold  for  realization  of  the  associated  tax  benefit.  In  the  event  that  the
Company determines that it would be able to realize more or less than the recorded amount of net deferred tax assets, an adjustment to the deferred tax asset
valuation allowance would be recorded in the period such a determination is made.

The valuation allowance at December 31, 2022 and 2021 primarily remained unchanged from respective prior periods; decreasing by an immaterial amount in
both periods.

F-43

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Description
Dollars in thousands
Year ended December 31, 2022

Deferred tax assets valuation allowance

Year ended December 31, 2021

Deferred tax assets valuation allowance

Year ended December 31, 2020

Deferred tax assets valuation allowance

Balance at
Beginning of
Period

Charged to
Costs and
Expenses

Other

Deductions

Balance at End
of Period

15,258 

(515)

13,825 

1,444 

12,069 

1,617 

(71)

(100)

139 

14,672 

15,258 

13,825 

89 

— 

As of December 31, 2022, the Company has not provided deferred income taxes on unrepatriated earnings from foreign subsidiaries as they are deemed to be
indefinitely reinvested unless there is a manner under which to remit the earnings with no material tax cost. Material taxes would primarily be attributable to
foreign withholding taxes and local income taxes when such earnings are distributed. The Company will repatriate foreign earnings when there is no need for
reinvestment overseas and no material tax cost to bring the earnings back to the United States. Reinvestment considerations would include future acquisitions,
transactions, and capital expenditure plans.

A reconciliation of the beginning and ending amount of uncertain tax benefits is as follows:

Dollars in thousands

Balance, beginning of year
Gross increases:
   Current year tax positions
   Prior years' tax positions
Other

Balance, end of year

Years Ended December 31,

2022

2021

(In thousands)

2020

676  $

37 
— 
— 
713  $

702  $

— 
— 
(26)
676  $

676 

— 
26 
— 
702 

$

$

Approximately $0.7 million of the balance at December 31, 2022 relates to uncertain tax positions that, if recognized, would affect the annual effective tax
rate.  The  Company  has  $0.3  million  of  uncertain  tax  positions  at  December  31,  2022  related  to  tax  positions  for  which  it  is  reasonably  possible  that  the
amounts could be reduced during the twelve months following December 31, 2022.

The Company recognizes interest and penalties relating to uncertain tax positions in income tax expense. The Company recognized a minimal benefit for the
years ended December 31, 2022, 2021 and 2020. The Company had minimal interest and penalties accrued for the years ended December 31, 2022 and 2021
and 2020.

The  Company  files  Federal  income  tax  returns,  as  well  as  multiple  state,  local  and  foreign  jurisdiction  tax  returns.  The  Company  is  no  longer  subject  to
examinations  of  its  U.S.  consolidated  Federal  income  tax  returns  by  the  IRS  through  fiscal  year  2015.  Additionally,  the  Company  is  no  longer  subject  to
examinations by the IRS for fiscal year 2017. All significant state and local matters have been concluded through fiscal year 2014. All significant foreign
matters have been settled through fiscal 2015.

F-44

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

13. NET INCOME PER SHARE

Basic and diluted net income per share was as follows:

 Dollars in thousands, except per share amounts
Basic net income per share:
Net income
Weighted average common shares outstanding
Basic net income per common share

Diluted net income per share:
Net income

Weighted average common shares outstanding — Basic
Effect of dilutive securities:

Stock options and restricted stock

Weighted average common shares for diluted earnings per share
Diluted net income per common share

Years Ended December 31,

2022

2021

2020

180,550  $
82,997 

2.18  $

169,075  $
84,698 

2.00  $

133,892 
84,650 
1.58 

180,550  $

169,075  $

133,892 

82,997 

519 
83,516 

84,698 

787 
85,485 

2.16  $

1.98  $

84,650 

577 
85,228 
1.57 

$

$

$

$

Common stock of approximately 0.3 million and 0.1 million shares at December 31, 2022, and 2021 that are issuable through exercise of dilutive securities,
respectively, and were not included in the computation of diluted net income per share because their effect would have been anti-dilutive.

Based on the adoption of ASU 2020-06, as the principal amount of the 2025 Notes will be paid in cash and only the conversion spread is settled in shares, the
Company will be utilizing the if-converted method and only includes the net number of incremental shares that would be issued upon conversion.

14. ACCUMULATED OTHER COMPREHENSIVE INCOME (LOSS)

Changes in accumulated other comprehensive loss by component between December 31, 2022 and 2021 are presented in the table below, net of tax:

Dollars in thousands
Balance at December 31, 2021

Other comprehensive gain (loss)
Less: Amounts reclassified from accumulated other

comprehensive income, net

Net current-period other comprehensive gain (loss)

Balance at December 31, 2022

Gains and Losses on
Derivatives

Defined Benefit Pension
Items

Foreign Currency Items

Total

$

$

(42,981) $
80,335 

14,537 
65,798 
22,817  $

1,893  $
7,429 

— 
7,429 
9,322  $

(4,067) $
(17,807)

— 
(17,807)
(21,874) $

(45,155)
69,957 

14,537 
55,420 
10,265 

For the year ended December 31, 2022, the Company reclassified a gain of $15.0 million and a loss of $0.4 million from accumulated other comprehensive
loss to other income, net and interest income, respectively.

15. COMMITMENTS AND CONTINGENCIES

In consideration for certain technology, manufacturing, distribution, and selling rights and licenses granted to the Company, the Company has agreed to pay
royalties on sales of certain products that it sells. The royalty payments that the Company made under these agreements were not significant for any of the
periods presented.

The Company is subject to various claims, lawsuits and proceedings in the ordinary course of the Company's business, including claims by current or former
employees,  distributors  and  competitors  and  with  respect  to  its  products  and  product  liability  claims,  lawsuits  and  proceedings,  some  of  which  have  been
settled by the Company. In the opinion of management, such claims are either adequately covered by insurance or otherwise indemnified, or are not expected,
individually or in the aggregate, to result in a material, adverse effect on the Company's financial condition. However, it is possible that the

F-45

 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Company's results of operations, financial position and cash flows in a particular period could be materially affected by these contingencies.

The Company accrues for loss contingencies when it is deemed probable that a loss has been incurred and that loss is estimable. The amounts accrued are
based on the full amount of the estimated loss before considering insurance proceeds and do not include an estimate for legal fees expected to be incurred in
connection with the loss contingency. The Company consistently accrues legal fees expected to be incurred in connection with loss contingencies as those fees
are incurred by outside counsel as a period cost.

Contingent Consideration

The Company determined the fair value of contingent consideration during the twelve-month period ended December 31, 2022 and 2021 to reflect the change
in estimate, additions, payments, transfers and the time value of money during the period.

A reconciliation of the opening balances to the closing balances of these Level 3 measurements for the years ended December 31, 2022 and 2021 is as follows
(in thousands):

Year ended December 31, 2022

Balance as of January 1,
2022
Additions
Transfers from long-term to
current portion
Change in fair value of
contingent consideration
liabilities
Balance as of December 31,
2022

Year ended December 31, 2021

Contingent Consideration Liability Related to Acquisition of:

Arkis 
 (See Note 4)

Location in
Financial
Statements

Derma
Sciences

ACell Inc.
 (See Note 4)

SIA

Location in Financial
Statements

Short-term

Long-term

Long-term

Short-term

Long-term

Long-term

$

3,691  $
— 

11,408 
— 

— 

— 

(846)

(1,358)

Research and
development

$

230  $
— 

—  $

21,800  $
— 

— 
57,607 

— 

— 

4,885 

(4,885)

(4,885)

(13,215)

— 

— 

Selling, general and
administrative

$

2,845  $

10,050 

$

230  $

—  $

3,700  $

57,607  $— 

Contingent Consideration Liability Related to Acquisition of:

Arkis 
 (See Note 4)

Location in
Financial
Statements

Derma Sciences

ACell Inc.
 (See Note 4)

Location in Financial
Statements

Short-term

Long-term

Long-term

Long-term

Balance as of January 1, 2021
Additions
Transfers from long-term to current portion
Change in fair value of contingent consideration
liabilities

Balance as of December 31, 2021

$

$

3,415  $
— 
276 

—  $
3,691  $

11,746 
— 
(276)

(62)
11,408 

Research and
development

$

$

230  $
— 
— 

— 
230  $

— 
23,900 
— 

(2,100)
21,800 

Selling, general and
administrative

Derma Sciences

The Company assumed contingent consideration incurred by Derma Sciences, Inc. ("Derma Sciences") related to its acquisitions of BioD and the intellectual
property  related  to  Medihoney  products.  The  Company  accounted  for  the  contingent  liabilities  by  recording  their  fair  value  on  the  date  of  the  acquisition
based  on  a  probability  weighted  income  approach.  The  Company  has  already  paid  $33.3  million  related  to  the  aforementioned  contingent  liabilities.  One
contingent milestone remains which relates to net sales of Medihoney™ products exceeding certain amounts defined in the agreement between the Company
and Derma Sciences. The potential maximum undiscounted payment amounts to $3.0 million. The estimated fair value as of December 31, 2022 and 2021
was $0.2 million.

F-46

 
 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

Arkis BioSciences, Inc.

As part of the acquisition of Arkis BioSciences, Inc. ("Arkis"), the Company is required to pay the former shareholders of Arkis up to $25.5 million based on
the timing of certain development milestones of $10 million and commercial sales milestones of $15.5 million, respectively. The Company used a probability
weighted  income  approach  to  calculate  the  fair  value  of  the  contingent  consideration  that  considered  the  possible  outcomes  of  scenarios  related  to  each
specified milestone. The Company estimated the fair value of the contingent consideration to be $13.1 million at the acquisition date. The estimated the fair
value as of December 31, 2022 was $12.9 million. The Company recorded $2.8 million in accrued expenses and other current liabilities and $10.1 million in
other liabilities at December 31, 2022 in the consolidated balance sheets of the Company.

16. SEGMENT AND GEOGRAPHIC INFORMATION

The Company internally manages two global reportable segments and reports the results of its businesses to its chief operating decision maker.
The two reportable segments and their activities are described below.

•

•

The  Codman  Specialty  Surgical  segment  includes  (i)  the  Neurosurgery  business,  which  sells  a  full  line  of  products  for  neurosurgery  and  neuro
critical care such as tissue ablation equipment, dural repair products, cerebral spinal fluid management devices, intracranial monitoring equipment,
and  cranial  stabilization  equipment  and  (ii)  the  Instruments  business,  which  sells  more  than  40,000  instrument  patterns  and  surgical  and  lighting
products to hospitals, surgery centers, dental, podiatry, and veterinary offices.

The  Tissue  Technologies  segment  includes  such  offerings  as  skin  and  wound  repair,  plastics  &  surgical  reconstruction  products,  bone  grafts,  and
nerve and tendon repair products.

The Corporate and other category includes (i) various executive, finance, human resource, information systems and legal functions, (ii) brand management,
and (iii) share-based compensation costs.

The  operating  results  of  the  various  reportable  segments  as  presented  are  not  comparable  to  one  another  because  (i)  certain  operating  segments  are  more
dependent than others on corporate functions for unallocated general and administrative and/or operational manufacturing functions, and (ii) the Company
does not allocate certain manufacturing costs and general and administrative costs to the operating segment results. Net sales and profit by reportable segment
for the years ended December 31, 2022, 2021 and 2020 are as follows:

Dollars in thousands
Segment Net Sales

Codman Specialty Surgical
 Tissue Technologies
Total revenues

Segment Profit

Codman Specialty Surgical
Tissue Technologies
Segment profit

Amortization
Corporate and other
Operating income

Years Ended December 31,

2022

2021

2020

$

$

$

$

1,019,564  $
538,102 
1,557,666  $

1,025,232  $
517,216 
1,542,448  $

417,873  $
233,802 
651,675 
(13,882)
(398,873)
238,920  $

439,471  $
228,199 
667,670 
(16,914)
(453,526)
197,230  $

894,831 
477,037 
1,371,868 

356,657 
159,630 
516,287 
(27,757)
(337,160)
151,370 

F-47

 
INTEGRA LIFESCIENCES HOLDINGS CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)

The Company does not allocate any assets to the reportable segments. No asset information is reported to the chief operating decision maker and disclosed in
the financial information for each segment. The Company attributes revenue to geographic areas based on the location of the customer. Total revenue, net and
long-lived assets (tangible) by major geographic area are summarized below:

Dollars in thousands
Total revenue, net:

2022
2021
2020

Total long-lived assets:

2022
2021

United States

(1)

Europe

Asia Pacific

Rest of the World

Consolidated

$

$

1,126,810  $
1,089,526 
971,975 

440,223  $
339,535 

170,903  $
191,327 
172,689 

60,857  $
55,026 

176,477  $
182,034 
157,174 

12,975  $
11,289 

83,476  $
79,561 
70,030 

2,721  $
6,836 

1,557,666 
1,542,448 
1,371,868 

516,776 
412,686 

F-48

Exhibit 3.3

Effective as of February 21, 2023

THIRD AMENDED AND RESTATED BYLAWS

OF

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

(the “Corporation”)

ARTICLE 1
OFFICES

Section 1.01    Offices. The Corporation may have offices at such places both within and without the State of Delaware as

the Board of Directors may from time to time determine or the business of the Corporation may require.

ARTICLE 2
MEETINGS OF STOCKHOLDERS

Section 2.01    Place of Meeting. Meetings of the stockholders shall be held at such place, within the State of Delaware or
elsewhere as may be fixed from time to time by the Board of Directors. If no place is so fixed for a meeting, it shall be held at the
Corporation’s then principal executive office. The Board of Directors may, in its sole discretion, determine that a meeting of
stockholders shall be held solely by means of remote communication as authorized by Section 211(a)(2) of the General Corporation
Law of the State of Delaware (the “DGCL”).

Section 2.02    Annual Meeting. The annual meeting of stockholders shall be held, unless the Board of Directors shall fix

some other hour or date therefor, at nine o’clock A.M. on the first Monday of May in each year, if not a legal holiday under the
laws of Delaware, and, if a legal holiday, then on the next succeeding secular day not a legal holiday under the laws of Delaware, at
which the stockholders shall elect a Board of Directors, and transact such other business as may properly be brought before the
meeting.

Section 2.03    Notice of Business to be Brought Before a Meeting.

(a)    At an annual meeting of stockholders, only such business shall be conducted as shall have been properly

brought before the meeting. To be properly brought before an annual meeting, business must be (i) brought before the meeting by
the Corporation and specified in the notice of meeting given by or at the direction of the Board of Directors, (ii) brought before the
meeting by or at the direction of the Board of Directors, or (iii) otherwise properly brought before the meeting by a stockholder
who (A) was a stockholder of record (and, with respect to any beneficial owner, if different, on whose behalf such business is
proposed, only if such beneficial owner was the beneficial owner of shares of the Corporation) both at the time of giving the notice
provided for in this Section 2.03 and at the time of the meeting, (B) is entitled to vote at the meeting, and (C) has complied with this
Section 2.03 as to such business. Except for proposals properly made in accordance with Rule 14a-8 under the Securities Exchange
Act of 1934, as amended, and the rules and regulations thereunder (as so amended and inclusive of such rules and regulations, the
“Exchange Act”), and included in the notice of meeting given by or at the direction of the Board of Directors, the foregoing clause
(iii) shall be the exclusive means for a stockholder to propose business to be brought before an annual meeting of the stockholders.
Stockholders shall not be permitted to propose business to be brought before a special meeting of the stockholders, and the only
matters that may be brought before a special meeting are the matters specified in the notice of meeting given by or at the direction
of the person calling the meeting pursuant to Section 2.04. Stockholders seeking to

1

 
 
Exhibit 3.3

Effective as of February 21, 2023

nominate persons for election to the Board must comply with Section 2.10 and this Section 2.03 shall not be applicable to
nominations except as expressly provided in Sections 2.03 or 2.10.

(b)    Without qualification, for business to be properly brought before an annual meeting by a stockholder, the

stockholder must (i) provide Timely Notice (as defined below) thereof in writing and in proper form to the Secretary of the
Corporation and (ii) provide any updates or supplements to such notice at the times and in the forms required by this Section 2.03.
To be timely, a stockholder’s notice must be delivered to, or mailed and received at, the principal executive offices of the
Corporation not less than ninety (90) days nor more than one hundred twenty (120) days prior to the one-year anniversary of the
preceding year’s annual meeting; provided, however, that if the date of the annual meeting is more than thirty (30) days before or
more than sixty (60) days after such anniversary date, notice by the stockholder to be timely must be so delivered, or mailed and
received, not later than the ninetieth (90 ) day prior to such annual meeting or, if later, the tenth (10 ) day following the day on
which public disclosure of the date of such annual meeting was first made (such notice within such time periods, “Timely Notice”).
In no event shall any adjournment of an annual meeting or the announcement thereof commence a new time period for the giving of
Timely Notice as described above.

th

th

(c)    To be in proper form for purposes of this Section 2.03, a stockholder’s notice to the Secretary shall set forth:

(i)    As to each Proposing Person (as defined below), (A) the name and address of such Proposing Person

(including, if applicable, the name and address that appear on the Corporation’s books and records); and (B) the class or series and
number of shares of the Corporation that are, directly or indirectly, owned of record or beneficially owned (within the meaning of
Rule 13d-3 under the Exchange Act) by such Proposing Persons, except that such Proposing Person shall in all events be deemed to
beneficially own any shares of any class or series of the Corporation as to which such Proposing Person has a right to acquire
beneficial ownership at any time in the future (whether or not such right is exercisable immediately or only after the passage of time
or upon the satisfaction of any conditions or both) pursuant to any agreement, arrangement or understanding (whether or not in
writing) (the disclosures to be made pursuant to the foregoing clauses (A) and (B) are referred to as “Stockholder Information”);

(ii)    As to each Proposing Person, (A) any derivative, swap or other transaction or series of transactions

engaged in, directly or indirectly, by such Proposing Person, the purpose or effect of which is to give such Proposing Person
economic risk similar to ownership of shares of any class or series of the Corporation, including due to the fact that the value of
such derivative, swap or other transactions are determined by reference to the price, value or volatility of any shares of any class or
series of the Corporation, or which derivative, swap or other transactions provide, directly or indirectly, the opportunity to profit
from any increase in the price or value of shares of any class or series of the Corporation (“Synthetic Equity Interests”), which
Synthetic Equity Interests shall be disclosed without regard to whether (x) the derivative, swap or other transactions convey any
voting rights in such shares to such Proposing Person, (y) the derivative, swap or other transactions are required to be, or are
capable of being, settled through delivery of such shares or (z) such Proposing Person may have entered into other transactions that
hedge or mitigate the economic effect of such derivative, swap or other transactions, (B) any proxy (other than a revocable proxy or
consent given in response to a solicitation made pursuant to, and in accordance with, Section 14(a) of the Exchange Act by way of a
solicitation statement filed on Schedule 14A), agreement, arrangement, understanding or relationship pursuant to which such
Proposing Person has or shares a right to vote any shares of any class or series of the Corporation, (C) any agreement, arrangement,
understanding or relationship, including any repurchase or similar so-called “stock borrowing” agreement or arrangement, engaged
in, directly or indirectly, by such Proposing Person, the purpose or effect

2

Exhibit 3.3

Effective as of February 21, 2023

of which is to mitigate loss to, reduce the economic risk (of ownership or otherwise) of shares of any class or series of the
Corporation by, manage the risk of share price changes for, or increase or decrease the voting power of, such Proposing Person with
respect to the shares of any class or series of the Corporation, or which provides, directly or indirectly, the opportunity to profit
from any decrease in the price or value of the shares of any class or series of the Corporation (“Short Interests”), (D) any rights to
dividends or other distributions on the shares of any class or series of capital stock of the Corporation, directly or indirectly, owned
beneficially by such Proposing Person or any of their affiliates or associates (as such terms are defined in Rule 12b-2 promulgated
under the Exchange Act) that are separated or separable from the underlying shares of the Corporation, (E) any performance related
fees (other than an asset based fee) that such Proposing Person is entitled to receive based on any increase or decrease in the price
or value of shares of any class or series of the Corporation, or any Synthetic Equity Interests or Short Interests, if any, (F)(1) if such
Proposing Person is not a natural person, the identity of the natural person or persons associated with such Proposing Person
responsible for (i) the formulation of and decision to propose the business to be brought before the meeting and (ii) making voting
and investment decisions on behalf of the Proposing Person (irrespective of whether such person or persons have “beneficial
ownership” for purposes of Rule 13d-3 of the Exchange Act of any securities owned of record or beneficially by the Proposing
Person) (such person or persons, the “Responsible Person”), the manner in which such Responsible Person was selected, any
fiduciary duties owed by such Responsible Person to the equity holders or other beneficiaries of such Proposing Person and, the
qualifications and background of such Responsible Person or (2) if such Proposing Person is a natural person, the qualifications and
background of such natural person, (G) any equity interests or any Synthetic Equity Interests in any principal competitor of the
Corporation beneficially owned by such Proposing Person or any of their affiliates or associates, (H) any direct or indirect interest
of such Proposing Person or any of their affiliates or associates in any contract with the Corporation, any affiliate of the
Corporation or any principal competitor of the Corporation (including, without limitation, in any such case, any employment
agreement, collective bargaining agreement or consulting agreement), (I) any pending or threatened litigation in which such
Proposing Person or any of their affiliates or associates is a party or material participant involving the Corporation or any of its
officers or directors, or any affiliate of the Corporation, (J) any material transaction occurring during the prior twelve months
between such Proposing Person or any of their affiliates or associates, on the one hand, and the Corporation, any affiliate of the
Corporation or any principal competitor of the Corporation, on the other hand, and (K) any other information relating to such
Proposing Person that would be required to be disclosed in a proxy statement or other filing required to be made in connection with
solicitations of proxies or consents by such Proposing Person in support of the business proposed to be brought before the meeting
pursuant to Section 14(a) of the Exchange Act (the disclosures to be made pursuant to the foregoing clauses (A) through (K) are
referred to as “Disclosable Interests”); provided, however, that Disclosable Interests shall not include any such disclosures with
respect to the ordinary course business activities of any broker, dealer, commercial bank, trust company or other nominee who is a
Proposing Person solely as a result of being the stockholder directed to prepare and submit a notice required by these Bylaws on
behalf of a beneficial owner;

(iii)    As to each item of business that the stockholder proposes to bring before the annual meeting, (A) a

reasonably brief description of the business desired to be brought before the annual meeting, the reasons for conducting such
business at the annual meeting and any material interest in such business of each Proposing Person and (B) the text of the proposal
or business (including the text of any resolutions or Bylaw amendment proposed for consideration);

of their affiliates or associates is a party (whether the

(iv)    A description of all agreements, arrangements or understandings to which any Proposing Person or any

3

Exhibit 3.3

Effective as of February 21, 2023

counterparty or counterparties are a Proposing Person or any affiliate or associate thereof, on the one hand, or one or more other
third parties, on the other hand, (including any nominee(s) proposed pursuant to Section 2.10), (a) pertaining to any nomination(s)
made pursuant to Section 2.10 or other business proposed to be brought before the meeting of stockholders or (b) entered into for
the purpose of acquiring, holding, disposing or voting of any shares of any class or series of capital stock of the Corporation (which
description shall identify the name of each other person who is party to such an agreement, arrangement or understanding), and (ii)
identification of the names and addresses of other stockholders (including beneficial owners) known by any of the Proposing
Persons to support any nominations made pursuant to Section 2.10 or other business proposal(s) and, to the extent known, the class
and number of all shares of the Corporation’s capital stock owned beneficially or of record by such other stockholder(s) or other
beneficial owner(s); and

(v)     A statement (i) that the stockholder is a holder of record of capital stock of the Corporation entitled to
vote at such meeting, a representation that such stockholder intends to appear in person or by proxy at the meeting to propose such
business or propose nominees pursuant to Section 2.10 and an acknowledgement that, if such stockholder (or a qualified
representative of such stockholder) does not appear to present such business or proposed nominees, as applicable, at such meeting,
the Corporation need not present such business or proposed nominees for a vote at such meeting, notwithstanding that proxies in
respect of such vote may have been received by the Corporation, (ii) whether or not the stockholder giving the notice and/or the
other Proposing Person(s), if any, (a) will deliver a proxy statement and form of proxy to holders of, in the case of a business
proposal, at least the percentage of voting power of all of the shares of capital stock of the Corporation required under applicable
law to approve the proposal or, in the case of a nomination or nominations made pursuant to Section 2.10, at least 67 percent of the
voting power of all of the shares of capital stock of the Corporation entitled to vote on the election of directors or (b) otherwise
solicit proxies or votes from stockholders in support of such proposal or nomination, as applicable, (iii) providing a representation
as to whether or not such Proposing Person intends to solicit proxies in support of director nominees other than the Corporation’s
director nominees in accordance with Rule 14a-19 promulgated under the Exchange Act, and (iv) that the stockholder will provide
any other information relating to such item of business that would be required to be disclosed in a proxy statement or other filing
required to be made in connection with solicitations of proxies in support of the business proposed to be brought before the meeting
pursuant to Section 14(a) of the Exchange Act.

For purposes of this Section 2.03, the term “Proposing Person” shall mean (i) the stockholder providing the notice of

business proposed to be brought before an annual meeting, (ii) the beneficial owner or beneficial owners, if different, on whose
behalf the notice of the business proposed to be brought before the annual meeting is made and (iii) any affiliate or associate (each
within the meaning of Rule 12b-2 under the Exchange Act for purposes of these Bylaws) of such stockholder or beneficial owner.

(d)    A stockholder providing notice of business proposed to be brought before an annual meeting shall further

update and supplement such notice, if necessary, so that the information provided or required to be provided in such notice pursuant
to this Section 2.03 shall be true and correct as of the record date for the meeting and as of the date that is ten (10) business days
prior to the meeting or any adjournment or postponement thereof, and such update and supplement shall be delivered to, or mailed
and received by, the Secretary at the principal executive offices of the Corporation not later than five (5) business days after the
record date for the meeting (in the case of the update and supplement required to be made as of the record date), and not later than
eight (8) business days prior to the date for the meeting or, if practicable, any adjournment or postponement thereof (and, if not
practicable, on the first practicable date prior to

4

Exhibit 3.3

Effective as of February 21, 2023

the date to which the meeting has been adjourned or postponed), in the case of the update and supplement required to be made as of
ten (10) business days prior to the meeting or any adjournment or postponement thereof. For the avoidance of doubt, the obligation
to update as set forth in this Section 2.03(d) shall not limit the Corporation’s rights with respect to any deficiencies in any notice
provided by a stockholder, extend any applicable deadlines hereunder, or enable or be deemed to permit a stockholder who has
previously submitted notice hereunder to amend or update any proposal or to submit any new proposal, including by changing or
adding nominees, matters, business and/or resolutions proposed to be brought before a meeting of the stockholders.
Notwithstanding the foregoing, if a Proposing Person no longer plans to solicit proxies in accordance with its representation
pursuant to Article II, Section 2.03(c)(v), such Proposing Person shall inform the Corporation of this change by delivering a written
notice to the Secretary at the principal executive offices of the Corporation no later than two (2) business days after making the
determination not to proceed with a solicitation of proxies. A Proposing Person shall also update its notice so that the information
required by Article II, Section 2.03(c) is current through the date of the meeting or any adjournment, postponement, or rescheduling
thereof, and such update shall be delivered in writing to the secretary at the principal executive offices of the Corporation no later
than two (2) business days after the occurrence of any material change to the information previously disclosed pursuant to Article
II, Section 2.03(c).

(e)    Notwithstanding anything in these Bylaws to the contrary, no business shall be conducted at an annual meeting

except in accordance with this Section 2.03. The Board of Directors or a designated committee thereof shall have the power to
determine whether any business proposed to be brought before the meeting was made in accordance with the provisions of these
Bylaws. If neither the Board of Directors nor such designated committee makes a determination as to whether any stockholder
proposal was made in accordance with these Bylaws, the presiding officer of the Annual Meeting shall have the power and duty to
determine whether the stockholder proposal was made in accordance with the provisions of these Bylaws. If the Board of Directors
or a designated committee thereof or the presiding officer of the meeting, as applicable, determines that any stockholder proposal
was not made in accordance with the provisions of these Bylaws, such proposal shall be disregarded and shall not be presented for
action at the annual meeting.

(f)    This Section 2.03 is expressly intended to apply to any business proposed to be brought before an annual

meeting of stockholders other than any proposal made pursuant to Rule 14a-8 under the Exchange Act. In addition to the
requirements of this Section 2.03 with respect to any business proposed to be brought before an annual meeting, each Proposing
Person shall comply with all applicable requirements of the Exchange Act with respect to any such business. If a stockholder fails
to comply with any applicable requirements of the Exchange Act, such stockholder’s proposed business shall be deemed to have
not been made in compliance with these Bylaws and shall be disregarded. Nothing in this Section 2.03 shall be deemed to affect the
rights of stockholders to request inclusion of proposals in the Corporation’s proxy statement pursuant to Rule 14a-8 under the
Exchange Act.

(g)    Notwithstanding the foregoing provisions of this Section 2.03, if the proposing stockholder (or a qualified

representative of the stockholder) does not appear at the Annual Meeting to present any business, such business shall be
disregarded, notwithstanding that proxies in respect of such vote may have been received by the Corporation. For purposes of this
Section 2.03, to be considered a qualified representative of the proposing stockholder, a person must be authorized by a written
instrument executed by such stockholder or an electronic transmission delivered by such stockholder to act for such stockholder as
proxy at the meeting of stockholders, and such person must produce such written instrument or electronic transmission, or a reliable
reproduction of the written instrument or electronic transmission, to the presiding officer at the meeting of stockholders.

5

Exhibit 3.3

Effective as of February 21, 2023

(h)    Except as otherwise required by law, nothing in this Section 2.03 shall obligate the Corporation or the Board of

Directors to include in any proxy statement or other stockholder communication distributed on behalf of the Corporation or the
Board of Directors information with respect to any nominee for director or any other matter of business submitted by a stockholder.

(i)    For purposes of these Bylaws, “public disclosure” shall mean disclosure in a press release reported by a

national news service or in a document publicly filed by the Corporation with the Securities and Exchange Commission pursuant to
Sections 13, 14 or 15(d) of the Exchange Act.

Section 2.04    Notice of Meetings. Notice of each meeting of stockholders shall be given which shall state the place, if any
(or the means of remote communication, if any, by which stockholders and proxy holders may be deemed to be present in person),
date and hour of the meeting and in the case of a special meeting, the purpose or purposes for which the meeting is called. Unless
otherwise provided by law, the certificate of incorporation or these bylaws, such notice shall be given to each stockholder entitled to
vote at such meeting not less than 10 days nor more than 60 days before the date of the meeting. Notice may be given personally,
by mail or by electronic transmission in accordance with Section 232 of the DGCL. If mailed, such notice shall be deemed given
when deposited in the United States mail, postage prepaid, directed to each stockholder at such stockholder’s address appearing on
the books of the Corporation or given by the stockholder for such purpose. Notice by electronic transmission shall be deemed given
as provided in Section 232 of the DGCL. An affidavit of the mailing or other means of giving any notice of any stockholders’
meeting, executed by the secretary, assistant secretary or any transfer agent of the Corporation giving the notice, shall be prima
facie evidence of the giving of such notice or report. Notice shall be deemed to have been given to all stockholders of record who
share an address if notice is given in accordance with the “householding” rules set forth in Rule 14a-3(e) under the Exchange Act
and Section 233 of the DGCL. When a meeting is adjourned to another time or place, if any (including an adjournment taken to
address a technical failure to convene or continue a meeting using remote communication), notice need not be given of the
adjourned meeting if the time and place, if any (and the means of remote communication, if any, by which stockholders and proxy
holders may be deemed to be present in person at such adjourned meeting), thereof are (i) announced at the meeting at which the
adjournment is taken, (ii) displayed during the time scheduled for the meeting on the same electronic network used to enable
stockholders and proxy holders to participate in the meeting by means of remote communication or (iii) set forth in the notice of the
meeting given in accordance with this Section 2.04; provided, however, that if the adjournment is for more than thirty (30) days or a
new record date is fixed for the adjourned meeting, in which case a notice of the adjourned meeting shall be given to each
stockholder of record entitled to vote at the meeting.

Section 2.05    List of Stockholders. The Corporation shall prepare, no later than the tenth (10 ) day before each meeting of
stockholders, a complete list of stockholders entitled to vote at the meeting, arranged in alphabetical order, and showing the address
of each stockholder and the number of shares registered in the name of each stockholder. Such list shall be open to the examination
of any stockholder, for any purpose germane to the meeting, during ordinary business hours, for a period of 10 days ending on the
day before the meeting date, (a) on a reasonably accessible electronic network, provided that the information required to gain
access to such list is provided with the notice of meeting, or (b) during ordinary business hours at the principal place of business of
the Corporation. Except as otherwise provided by law, the stock ledger shall be the only evidence as to the stockholders who are
entitled to examine the list of stockholders required by this Section 2.05 or to vote in person or by proxy at any meeting of
stockholders.

th

6

Exhibit 3.3

Effective as of February 21, 2023

Section 2.06    Inspector of Election. Prior to any meeting of stockholders, the board of directors, the chairman of the board,
the president or the secretary shall appoint an inspector of election. Such inspectors for election shall have the powers and duties set
forth in Section 231 of the DGCL and may include individuals who serve the Corporation in other capacities, including, without
limitation, as officers, employees, agents or representatives, to act at such meeting and make a written report thereof. Each
inspector of election, before discharging his or her duties, shall take and sign an oath to execute faithfully the duties of inspector
with strict impartiality and according to the best of his or her ability. The inspectors of election shall have the duties prescribed by
law.

Section 2.07    Special Meetings. Special meetings of the stockholders, for any purpose or purposes, unless otherwise

prescribed by statute or by the Certificate of Incorporation, may be called only by the Chairman of the Board, the President or the
Board of Directors. Such request shall state the purpose or purposes of the proposed meeting. Business transacted at any special
meeting of stockholders shall be limited to the purposes stated in the notice.

Section 2.08    Quorum; Voting.

(a)    The holders of a majority of the stock issued and outstanding and entitled to vote thereat, present in person or

by remote communication, or represented by proxy, shall constitute a quorum at all meetings of the stockholders for the transaction
of business except as otherwise provided by statute or by the Certificate of Incorporation. If, however, such quorum shall not be
present or represented at any meeting of the stockholders, the stockholders entitled to vote thereat, present in person or represented
by proxy, shall have power to adjourn the meeting from time to time, without notice other than announcement at the meeting, until
a quorum shall be present or represented. At such adjourned meeting at which a quorum shall be present or represented, any
business may be transacted which might have been transacted at the meeting as originally notified. At any meeting of stockholders
(at which a quorum is present to organize the meeting), all matters, except as otherwise provided by applicable law, pursuant to any
regulation applicable to the Corporation or its securities or by the Certificate of Incorporation or by these Bylaws (including the
election of directors), shall be decided by the affirmative vote of a majority in voting power of shares present in person or
represented by proxy and entitled to vote thereon. Unless otherwise provided in the Certificate of Incorporation, each stockholder
shall at every meeting of stockholders be entitled to one vote in person or by proxy for each share of the capital stock having voting
power held by such stockholder, but no shares shall be voted pursuant to a proxy more than three years after the date of the proxy
unless the proxy provides for a longer period. The Board of Directors may by resolution establish a method for stockholders to cast
their vote by a secure electronic method. In the event the Corporation receives proxies for disqualified or withdrawn nominees for
the Board of Directors, such votes for such disqualified or withdrawn nominees in the proxies will be treated as abstentions.

(b)    Any stockholder directly or indirectly soliciting proxies from other stockholders must use a proxy card color

other than white, which shall be reserved for the exclusive use by the Board of Directors.

Section 2.09    Action Without a Meeting.

(a)    Unless otherwise restricted by the Certificate of Incorporation, any action required or permitted to be taken at

any annual or special meeting of stockholders may be taken without a meeting, without prior notice and without a vote, if a consent
or consents in writing setting forth the action so taken, (i) shall be signed by the holders of record on the record date (established as
provided below) of outstanding stock of the Corporation having not less than the minimum number of votes that would be
necessary to authorize or take such action at a meeting

7

Exhibit 3.3

Effective as of February 21, 2023

at which all shares entitled to vote thereon were present and voted and (ii) shall be delivered to the Corporation by delivery to its
registered office in the State of Delaware, its principal place of business, or an officer or agent of the Corporation having custody of
the book in which proceedings of meetings of stockholders are recorded. Delivery made to a Corporation’s registered office shall be
by hand or by certified or registered mail, return receipt requested. Every written consent shall bear the date of signature of each
stockholder who signs the consent, and no written consent shall be effective to take the corporate action referred to therein unless,
within sixty days after the earliest dated consent delivered in the manner required by this Section 2.09 to the Corporation, written
consents signed by a sufficient number of stockholders to take action are delivered in the manner required by this Section to the
Corporation. Prompt notice of the taking of the corporate action without a meeting by less than unanimous written consent shall be
given to those stockholders who have not consented in writing.

(b)    Without qualification, any stockholder of record seeking to have the stockholders authorize or take any action

by written consent shall first request in writing that the Board of Directors fix a record date for the purpose of determining the
stockholders entitled to take such action, which request shall be in proper form and delivered to, or mailed and received by, the
Secretary of the Corporation at the principal executive offices of the Corporation. Within ten (10) days after receipt of a request in
proper form and otherwise in compliance with this Section 2.09(b) from any such stockholder, the Board of Directors may adopt a
resolution fixing a record date for the purpose of determining the stockholders entitled to take such action, which date shall not
precede the date upon which the resolution fixing the record date is adopted by the Board of Directors, and which date shall not be
more than ten (10) days after the date upon which the resolution fixing the record date is adopted by the Board of Directors. If no
resolution fixing a record date has been adopted by the Board of Directors within such ten (10) day period after the date on which
such a request is received, (i) the record date for determining stockholders entitled to consent to such action, when no prior action
of the Board of Directors is required by applicable law, shall be the first date on which a valid signed written consent setting forth
the action taken or proposed to be taken is delivered to the Corporation in the manner described in this Section 2.09, and (ii) the
record date for determining stockholders entitled to consent to such action, when prior action by the Board of Directors is required
by applicable law, shall be at the close of business on the date on which the Board of Directors adopts the resolution taking such
prior action.

(c)    In the event of the delivery, in the manner provided by this Section 2.09 and applicable law, to the Corporation

of written consent or consents to take corporate action and/or any related revocation or revocations, the Corporation shall engage
independent inspectors of elections for the purpose of performing promptly a ministerial review of the validity of the consents and
revocations. For the purpose of permitting the inspectors to perform such review, no action by written consent and without a
meeting shall be effective until such inspectors have completed their review, determined that the requisite number of valid and
unrevoked consents delivered to the Corporation in accordance with this Section 2.09 and applicable law have been obtained to
authorize or take the action specified in the consents, and certified such determination for entry in the records of the Corporation
kept for the purpose of recording the proceedings of meetings of stockholders. Nothing contained in this Section 2.09 shall in any
way be construed to suggest or imply that the Board or any stockholder shall not be entitled to contest the validity of any consent or
revocation thereof, whether before or after such certification by the independent inspectors, or to take any other action (including,
without limitation, the commencement, prosecution or defense of any litigation with respect thereto, and the seeking of injunctive
relief in such litigation).

(d)    Notwithstanding anything in these Bylaws to the contrary, no action may be taken by the stockholders by

written consent except in accordance with this Section 2.09. If

8

Exhibit 3.3

Effective as of February 21, 2023

the Board of Directors shall determine that any request to fix a record date or to take stockholder action by written consent was not
properly made in accordance with this Section 2.09, or the stockholder or stockholders seeking to take such action do not otherwise
comply with this Section 2.09, then the Board of Directors shall not be required to fix a record date and any such purported action
by written consent shall be null and void to the fullest extent permitted by applicable law. In addition to the requirements of this
Section 2.09 with respect to stockholders seeking to take an action by written consent, each soliciting person shall comply with all
requirements of applicable law, including all requirements of the Exchange Act, with respect to such action.

Section 2.10    Notice of Nominations for Election to the Board of Directors.

(a)    Nominations of any person for election to the Board of Directors at an annual meeting or at a special meeting
(but only if the election of directors is a matter specified in the notice of meeting given by or at the direction of the person calling
such special meeting) may be made at such meeting only (i) by or at the direction of the Board of Directors, including by any
committee or persons appointed by the Board of Directors, or (ii) by a stockholder who (A) was a stockholder of record (and, with
respect to any beneficial owner, if different, on whose behalf such nomination is proposed to be made, only if such beneficial owner
was the beneficial owner of shares of the Corporation) both at the time of giving the notice provided for in this Section 2.10 and at
the time of the meeting, (B) is entitled to vote at the meeting, and (C) has complied with this Section 2.10 as to such nomination.
The foregoing clause (ii) shall be the exclusive means for a stockholder to make any nomination of a person or persons for election
to the Board of Directors at an annual meeting or special meeting.

(b)    Without qualification, for a stockholder to make any nomination of a person or persons for election to the
Board of Directors at an annual meeting, the stockholder must (i) provide Timely Notice (as defined in Section 2.03) thereof in
writing and in proper form to the Secretary of the Corporation and (ii) provide any updates or supplements to such notice at the
times and in the forms required by this Section 2.10. Without qualification, if the election of directors is a matter specified in the
notice of meeting given by or at the direction of the person calling a special meeting, then for a stockholder to make any nomination
of a person or persons for election to the Board of Directors at a special meeting, the stockholder must (i) provide timely notice
thereof in writing and in proper form to the Secretary of the Corporation at the principal executive offices of the Corporation, and
(ii) provide any updates or supplements to such notice at the times and in the forms required by this Section 2.10. To be timely, a
stockholder’s notice for nominations to be made at a special meeting must be delivered to, or mailed and received at, the principal
executive offices of the Corporation not earlier than the one hundred twentieth (120 ) day prior to such special meeting and not
later than the ninetieth (90 ) day prior to such special meeting or, if later, the tenth (10 ) day following the day on which public
disclosure (as defined in Section 2.03) of the date of such special meeting was first made. In no event shall any adjournment of an
annual meeting or special meeting or the announcement thereof commence a new time period for the giving of a stockholder’s
notice as described above.

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(c)    To be in proper form for purposes of this Section 2.10, a stockholder’s notice to the Secretary shall set forth:

(i)    As to each Nominating Person (as defined below), the Stockholder Information (as defined in Section
2.03(c)(i), except that for purposes of this Section 2.10 the term “Nominating Person” shall be substituted for the term “Proposing
Person” in all places it appears in Section 2.03(c)(i));

9

Exhibit 3.3

Effective as of February 21, 2023

(ii)    As to each Nominating Person, any Disclosable Interests (as defined in Section 2.03(c)(ii), except that
for purposes of this Section 2.10 the term “Nominating Person” shall be substituted for the term “Proposing Person” in all places it
appears in Section 2.03(c)(ii) and the disclosure in clause (K) of Section 2.03(c)(ii) shall be made with respect to the election of
directors at the meeting);

(iii)    As to each person whom a Nominating Person proposes to nominate for election as a director, (A) all
information with respect to such proposed nominee that would be required to be set forth in a stockholder’s notice pursuant to this
Section 2.10 if such proposed nominee were a Nominating Person, (B) a questionnaire with respect to the background and
qualifications of the nominee completed by the nominee in the form provided by the Corporation (which questionnaire shall be
provided by the Secretary upon written request); (C) a representation and agreement in the form provided by the Corporation
(which form shall be provided by the Secretary upon written request) that: (a) such proposed nominee is not and will not become
party to any agreement, arrangement or understanding with any person or entity as to how such proposed nominee, if elected as a
director of the Corporation, will act or vote on any issue or question (a “Voting Commitment”) that has not been disclosed to the
Corporation; (b) such proposed nominee is not and will not become a party to any agreement, arrangement, or understanding with
any person or entity other than the Corporation with respect to any direct or indirect compensation, reimbursement, or
indemnification in connection with service or action as a director that has not been disclosed to the Corporation; (c) such proposed
nominee would, if elected as a director, comply with all applicable rules and regulations of the exchanges upon which shares of the
Corporation’s capital stock trade, each of the Corporation’s corporate governance, ethics, conflict of interest, confidentiality, stock
ownership and trading policies and guidelines applicable generally to the Corporation’s directors and, if elected as a director of the
Corporation, such person currently would be in compliance with any such policies and guidelines that have been publicly disclosed;
(d) such proposed nominee intends to serve as a director for the full term for which he or she is to stand for election; (e) such
proposed nominee, if elected, intends to tender, promptly following such person’s election or re-election, an irrevocable resignation
effective upon such person’s failure to receive the required vote for re-election at the next meeting at which such person would face
re-election and upon acceptance of such resignation by the Board of Directors; and (f) such proposed nominee will promptly
provide to the Corporation such other information as it may reasonably request; (D) all information relating to such proposed
nominee that is required to be disclosed in a proxy statement or other filings required to be made in connection with solicitations of
proxies for election of directors in a contested election pursuant to Section 14(a) under the Exchange Act (including such proposed
nominee’s written consent to being named in the proxy statement as a nominee and to serving as a director if elected), (E) a
description of all arrangements or understandings between or among the stockholder and each nominee and any other person or
persons (naming such person or persons) pursuant to which the nominations are to be made by the stockholder or concerning the
nominee’s potential service on the Board of Directors, and (F) a description of all direct and indirect compensation and other
material monetary agreements, arrangements and understandings during the past three years, and any other material relationships,
between or among any Nominating Person, on the one hand, and each proposed nominee, or his or her respective affiliates and
associates, on the other hand, including, without limitation, all information that would be required to be disclosed pursuant to Item
404 under Regulation S-K if such Nominating Person were the “registrant” for purposes of such rule and the proposed nominee
were a director or executive officer of such registrant (the disclosures to be made pursuant to the foregoing clauses (A) through (F)
are referred to as “Nominee Information”); and

reasonably be required by the Corporation to determine the eligibility of such proposed nominee to serve as an independent director
of the Corporation in

(iv)    The Corporation may require any proposed nominee to furnish such other information (A) as may

10

Exhibit 3.3

Effective as of February 21, 2023

accordance with the Corporation’s Corporate Governance Guidelines or (B) that could be material to a reasonable stockholder’s
understanding of the independence or lack of independence of such proposed nominee.

For purposes of this Section 2.10, the term “Nominating Person” shall mean (i) the stockholder providing the notice of the

nomination proposed to be made at the meeting, (ii) the beneficial owner or beneficial owners, if different, on whose behalf the
notice of the nomination proposed to be made at the meeting is made and (iii) any affiliate or associate of such stockholder or
beneficial owner.

(d)    A stockholder providing notice of any nomination proposed to be made at a meeting shall further update and

supplement such notice, if necessary, so that the information provided or required to be provided in such notice pursuant to this
Section 2.10 shall be true and correct as of the record date for the meeting and as of the date that is ten (10) business days prior to
the meeting or any adjournment or postponement thereof, and such update and supplement shall be delivered to, or mailed and
received by, the Secretary at the principal executive offices of the Corporation not later than five (5) business days after the record
date for the meeting (in the case of the update and supplement required to be made as of the record date), and not later than eight
(8) business days prior to the date for the meeting or, if practicable, any adjournment or postponement thereof (and, if not
practicable, on the first practicable date prior to the date to which the meeting has been adjourned or postponed) (in the case of the
update and supplement required to be made as of ten (10) business days prior to the meeting or any adjournment or postponement
thereof). For the avoidance of doubt, the obligation to update as set forth in this Section 2.10(d) shall not limit the Corporation’s
rights with respect to any deficiencies in any notice provided by a stockholder, extend any applicable deadlines hereunder, or enable
or be deemed to permit a stockholder who has previously submitted notice hereunder to amend or update any nomination or to
submit any new nominees, including by changing or adding nominees proposed to be brought before a meeting of the stockholders.
Notwithstanding the foregoing, if a Nominating Person no longer plans to solicit proxies in accordance with its representation
pursuant to Article II, Section 2.03(c)(v), such Nominating Person shall inform the Corporation of this change by delivering a
written notice to the Secretary at the principal executive offices of the Corporation no later than two (2) business days after making
the determination not to proceed with a solicitation of proxies. A Nominating Person shall also update its notice so that the
information required by Article II, Section 2.10(c) is current through the date of the meeting or any adjournment, postponement, or
rescheduling thereof, and such update shall be delivered in writing to the secretary at the principal executive offices of the
Corporation no later than two (2) business days after the occurrence of any material change to the information previously disclosed
pursuant to Article II, Section 2.10(c).

(e)    Notwithstanding anything in these Bylaws to the contrary, no person shall be eligible for election as a director

of the Corporation unless nominated in accordance with this Section 2.10. The Board of Directors or a designated committee
thereof shall have the power to determine whether a nomination proposed to be brought before the meeting was made in accordance
with the provisions of these Bylaws. If neither the Board of Directors nor such designated committee makes a determination as to
whether any stockholder nomination was made in accordance with the provisions of these Bylaws, the presiding officer of the
meeting shall have the power and duty to determine whether the stockholder nomination was made in accordance with the
provisions of these Bylaws. If the Board of Directors or a designated committee thereof or the presiding officer, as applicable,
determines that any stockholder nomination was not made in accordance with the provisions of these Bylaws, such nomination
shall be disregarded and shall not be presented for action at the meeting.

11

Exhibit 3.3

Effective as of February 21, 2023

(f)    Notwithstanding the foregoing provisions of this Section 2.10, if the Nominating Person (or a qualified
representative of the Nominating Person) does not appear at the meeting to present a nomination, such nomination shall be
disregarded, notwithstanding that proxies in respect of such vote may have been received by the Corporation. For purposes of this
Section 2.10, to be considered a qualified representative of the Nominating Person, a person must be authorized by a written
instrument executed by such Nominating Person or an electronic transmission delivered by such Nominating Person to act for such
Nominating Person as proxy at the meeting of stockholders, and such person must produce such written instrument or electronic
transmission, or a reliable reproduction of the written instrument or electronic transmission, to the presiding officer at the meeting
of stockholders.

(g)    Except as otherwise required by law, including, but not limited to, Rule 14a-19 of the Exchange Act, nothing in

this Section 2.10 shall obligate the Corporation or the Board of Directors to include in any proxy statement or other stockholder
communication distributed on behalf of the Corporation or the Board of Directors information with respect to any nominee for
director submitted by a stockholder.

(h)    Notwithstanding the foregoing provisions of this Bylaw, a stockholder shall also comply with all applicable

requirements of the Exchange Act and the rules and regulations thereunder, including, but not limited to, Rule 14a-19 of the
Exchange Act, with respect to the matters set forth in this Bylaw. If a stockholder fails to comply with any applicable requirements
of the Exchange Act, including, but not limited to, Rule 14a-19 promulgated thereunder, such stockholder’s proposed nomination
shall be deemed to have not been made in compliance with this Bylaw and shall be disregarded.

(i)    Further notwithstanding the foregoing provisions of these Bylaws, unless otherwise required by law, (i) no

Nominating Person shall solicit proxies in support of director nominees other than the Corporation’s nominees unless such
Nominating Person has complied with Rule 14a-19 promulgated under the Exchange Act in connection with the solicitation of such
proxies, including the provision to the Corporation of notices required thereunder with timely notice, and (ii) if any Nominating
Person (A) provides notice pursuant to Rule 14a-19(b) promulgated under the Exchange Act, (B) subsequently fails to comply with
the requirements of Rule 14a-19(a)(2) or Rule 14a-19(a)(3) promulgated under the Exchange Act, including the provision to the
Corporation of notices required thereunder with timely notice, and (C) no other Nominating Person has provided notice pursuant to,
and in compliance with, Rule 14a-19 under the Exchange Act that it intends to solicit proxies in support of the election of such
proposed nominee in accordance with Rule 14a-19(b) under the Exchange Act, then such proposed nominee shall be disqualified
from nomination, the Corporation shall disregard the nomination of such proposed nominee and no vote on the election of such
proposed nominee shall occur. Upon request by the Corporation, if any Nominating Person provides notice pursuant to Rule 14a-
19(b) promulgated under the Exchange Act, such Nominating Person shall deliver to the Corporation, no later than five (5) business
days prior to the applicable meeting date, reasonable evidence that it has met the requirements of Rule 14a-19(a)(3) promulgated
under the Exchange Act.

(j)    The number of nominees a stockholder may nominate for election at the annual meeting of stockholders (or in

the case of a stockholder giving the notice on behalf of a beneficial owner, the number of nominees a stockholder may nominate for
election at the annual meeting of stockholders on behalf of such beneficial owner) shall not exceed the number of directors to be
elected at such annual meeting of stockholders.

Section 2.11    Chairman and Secretary at Meetings. At any meeting of stockholders, the Chairman of the Board of
Directors, or in his or her absence, the President, or if neither such person is available, then a person designated by the Board of
Directors, shall preside at and act as

12

Exhibit 3.3

Effective as of February 21, 2023

chairman of the meeting. The Secretary, or in his or her absence a person designated by the chairman of the meeting, shall act as
secretary of the meeting and keep a record of the proceedings thereof. The Board of Directors may adopt by resolution such rules,
regulations, and procedures for the conduct of the meeting of stockholders as it shall deem appropriate.

Except to the extent inconsistent with such rules, regulations, and procedures as adopted by the Board of Directors, the

chairman of the meeting shall have the right and authority to convene and to adjourn the meeting, to prescribe such rules,
regulations and procedures, and to do all such acts as, in the judgment of such chairman of the meeting, are appropriate for the
proper conduct of the meeting. Such rules, regulations, or procedures, whether adopted by the Board of Directors or the chairman of
the meeting, may include, without limitation, the following: (a) the establishment of an agenda for the meeting; (b) rules and
procedures for maintaining order at the meeting and the safety of those present at the meeting; (c) limitations on attendance at or
participation in the meeting to stockholders of record of the Corporation, their duly authorized and constituted proxies, or such
other persons as the chair of the meeting shall determine; (d) restrictions on entry to the meeting after the time fixed for the
commencement thereof; (e) the determination of the circumstances in which any person may make a statement or ask questions and
limitations on the time allotted to questions or comments; (f) the determination of when the polls shall open and close for any given
matter to be voted on at the meeting; (g) the exclusion or removal of any stockholders or any other individual who refuses to
comply with meeting rules, regulations, or procedures; (h) restrictions on the use of audio and video recording devices, cell phones,
and other electronic devices; (i) rules, regulations, and procedures for compliance with any federal, state, or local laws or
regulations (including those concerning safety, health, or security); (j) procedures (if any) requiring attendees to provide the
Corporation advance notice of their intent to attend the meeting; and (k) rules, regulations, or procedures regarding the participation
by means of remote communication of stockholders and proxy holders not physically present at a meeting, whether such meeting is
to be held at a designated place or solely by means of remote communication.

The chairman of the meeting, in addition to making any other determinations provided for elsewhere in these bylaws or that
may be appropriate to the conduct of the meeting, shall, if the facts warrant, determine and declare to the meeting that business or a
nomination was not properly brought before the meeting, and if such chairman should so determine, such chairman shall so declare
to the meeting and shall not be required to transact or consider any such business or nomination. Unless and to the extent
determined by the Board of Directors or the chairman of the meeting, meetings of stockholders shall not be required to be held in
accordance with the rules of parliamentary procedure. The chairman of the meeting shall fix and announce at the meeting the date
and time of the opening and closing of the polls for each matter upon which the stockholders will vote at the meeting.

ARTICLE 3
DIRECTORS

Section 3.01    Number and Term of Office. The number of directors of the Corporation shall be not less than three nor more

than thirteen, as designated from time to time by resolution of the Board of Directors. The directors shall be elected at the annual
meeting of the stockholders, except as provided in Section 3.02 hereof. Except as provided in Section 3.02 hereof, each director
shall be elected by the vote of the majority of the votes cast with respect to the director, provided that if the number of nominees
exceeds the number of directors to be elected, the directors shall be elected by the vote of a plurality of the votes cast. For purposes
of this Section 3.01, a majority of the votes cast means that the number of shares voted “for” a director must exceed the number of
votes cast “against” that director. If a director is not elected, the director shall offer to tender his or her resignation to the Board of
Directors. The Nominating

13

 
Exhibit 3.3

Effective as of February 21, 2023

and Corporate Governance Committee will make a recommendation to the Board of Directors on whether to accept or reject the
resignation, or whether other action should be taken. The Board of Directors will act on the Committee’s recommendation and
publicly disclose its decision and the rationale behind it within 90 days from the date of the certification of the election results.

The director who tenders his or her resignation will not participate in the Board of Directors’ decision. Directors shall hold

office until the next annual meeting of stockholders and until their successors shall be duly elected and qualified or until their
earlier death, resignation or removal. Directors need not be stockholders. If, for any cause, the Board of Directors shall not have
been elected at an annual meeting of stockholders, they may be elected as soon thereafter as convenient at a special meeting of the
stockholders called for that purpose in the manner provided in these Bylaws.

Section 3.02    Vacancies. Vacancies and newly created directorships resulting from any increase in the authorized number

of directors may only be filled by a majority of the directors then in office, though less than a quorum, or by a sole remaining
director, and the directors so chosen shall hold office until the next annual election and until their successors are duly elected and
shall qualify, unless sooner displaced. If there are no directors in office, then an election of directors may be held in the manner
provided by statute.

Section 3.03    Resignations. Any director may resign at any time by giving written notice (or notice by electronic
transmission) to the Board of Directors, the Chairman of the Board, the President, or the Secretary. Such resignation shall take
effect at the time of receipt thereof or at any later time specified therein; and, unless otherwise specified therein, the acceptance of
such resignation shall not be necessary to make it effective. A resignation which is conditioned upon the director failing to receive a
specified vote for re-election as a director may provide that it is irrevocable.

Section 3.04    Direction of Management. The business of the Corporation shall be managed under the direction of its Board

of Directors, which may exercise all such powers of the Corporation and do all such lawful acts and things as are not by statute or
by the Certificate of Incorporation or by these Bylaws directed or required to be exercised or done by the stockholders.

Section 3.05    Place of Meetings. The Board of Directors of the Corporation may hold meetings, both regular and special,

either within or without the State of Delaware.

Section 3.06    Annual Meeting. Immediately after each annual election of directors or at such other time as the Board of

Directors may determine, the Board of Directors shall meet for the purpose of organization, election of officers, and the transaction
of other business, at the place where such election of directors was held or, if notice of such meeting is given, at the place specified
in such notice. Notice of such meeting need not be given. In the absence of a quorum at said meeting, the same may be held at any
other time and place which shall be specified in a notice given as hereinafter provided for special meetings of the Board of
Directors, or as shall be specified in a written waiver signed by the directors, if any, not attending and participating in the meeting.

Section 3.07    Regular Meetings. Regular meetings of the Board of Directors may be held without notice at such time and

place as shall from time to time be determined by the Board of Directors.

Section 3.08    Special Meetings. Special meetings of the Board of Directors may be called by the Chairman of the Board or

the President on 2 days’ notice to each director either

14

Exhibit 3.3

Effective as of February 21, 2023

personally (including by telephone or by means of electronic transmission), or in the manner specified in Section 4.01. Special
meetings shall be called by the Chairman of the Board, or the President or the Secretary in like manner and on like notice of the
written request (or request by electronic transmission) of two directors.

Section 3.09    Quorum; Voting. At all meetings of the Board of Directors, a majority of the directors shall constitute a

quorum for the transaction of business; and at all meetings of any committee of the Board of Directors, a majority of the members
of such committee shall constitute a quorum for the transaction of business. The act of a majority of the directors present at any
meeting of the Board of Directors or any committee thereof at which there is a quorum present shall be the act of the Board of
Directors or such committee, as the case may be, except as may be otherwise specifically provided by statute or by the Certificate
of Incorporation. If a quorum shall not be present at any meeting of the Board of Directors or committee thereof, the directors
present thereat may adjourn the meeting from time to time, without notice other than announcement at the meeting, until a quorum
shall be present.

Section 3.10    Action Without a Meeting. Any action required or permitted to be taken at any meeting of the Board of

Directors or of any committee thereof may be taken without a meeting, if all members of the Board of Directors or committee, as
the case may be, consent thereto in writing or by electronic transmission, and the writing or writings (or electronic transmission or
transmissions) are filed with the minutes of proceedings of the Board of Directors or committee, as applicable.

Section 3.11    Telephonic Meeting Permitted. Members of the Board of Directors or any committee thereof may participate

in and act at any meeting of such board or committee through the use of a conference telephone or other communications
equipment by means of which all persons participating can hear each other, and participation in the meeting pursuant to this Section
3.11 shall constitute presence in person at the meeting except when the person attends for the express purpose of objecting at the
beginning of the meeting to the transaction of any business because the meeting is not lawfully called or convened.

Section 3.12    Committees of Directors. The Corporation elects to be governed by Section 141(c)(2) of the DGCL. The
Board of Directors may, by resolution passed by a majority of the whole Board of Directors, designate one or more committees,
each committee to consist of one or more of the directors of the Corporation. The Board of Directors may designate one or more
directors as alternate members of any committee, who may replace any absent or disqualified member at any meeting of the
committee. Any such committee, to the extent provided in the resolution, shall have and may exercise all of the powers and
authority of the Board of Directors in the management of the business and affairs of the Corporation, except as expressly limited by
Section 141(c)(2) of the DGCL. Such committee or committees shall have such name or names as may be determined from time to
time by resolution adopted by the Board of Directors. Each committee shall keep regular minutes of its meetings and report the
same to the Board of Directors when requested.

Section 3.13    Compensation of Directors. Each director shall be entitled to receive such compensation, if any, as may from
time to time be fixed by the Board of Directors. Members of special or standing committees may be allowed like compensation for
attending committee meetings. Directors may also be reimbursed by the Corporation for all reasonable expenses incurred in
traveling to and from the place of each meeting of the Board of Directors or of any such committee or otherwise incurred in the
performance of their duties as directors. No payment referred to herein shall preclude any director from serving the Corporation in
any other capacity and receiving compensation therefor.

15

Exhibit 3.3

Effective as of February 21, 2023

Section 3.14    Presiding Director. The Board of Directors may appoint a presiding director of the Board of Directors to hold

such position for a term not to exceed one year. Such term shall end on the earlier of the date of the next annual meeting of
stockholders or until such presiding director’s earlier death, resignation or removal from such position. The Board of Directors shall
determine the qualifications and duties of any such presiding director, including, but not limited to, presiding over meetings of the
Board of Directors if the Chairman of the Board is absent.

ARTICLE 4
NOTICES

Section 4.01    Notices. Subject to Section 2.04 of the Bylaws with respect to notice of meetings of stockholders, whenever,
under the provisions of law or of the Certificate of Incorporation or of these Bylaws, notice is required to be given to any director or
stockholder, such requirement shall not be construed to necessitate personal notice. Whenever written notice is required by law to
be given to any director or stockholder, such notice may be given by mail, addressed to such director or stockholder, at such
person’s address as it appears on the records of the Corporation, with postage thereon prepaid, and such notice shall be deemed
given when deposited in the United States mail. Notice to directors may also be given by electronic transmission. Without limiting
the manner by which notice otherwise may be given to stockholders, any notice to stockholders may be given by electronic
transmission in the manner provided in Section 232 of the DGCL.

Section 4.02    Waiver of Notice. Whenever, under the provisions of law or of the Certificate of Incorporation or of these
Bylaws, notice is required to be given, a waiver thereof in writing or electronic transmission, by the person or persons entitled to
said notice, whether before or after the time of the event for which notice is to be given, shall be deemed equivalent thereto. In the
case of a stockholder, such waiver of notice may be signed by such stockholder’s attorney or proxy duly appointed in writing or
otherwise permitted by law. Neither the business nor the purpose of any meeting need be specified in any waiver.

ARTICLE 5
OFFICERS

Section 5.01    Number. The officers of the Corporation shall be a Chairman of the Board, a Chief Executive Officer, a

President, a Chief Financial Officer, a Secretary and a Treasurer, and may also include one or more Vice Presidents (who may be
further classified by such descriptions as “executive”, “senior”, “assistant”, or otherwise), one or more Assistant Secretaries and
Assistant Treasurers, and such other officers as may be elected by the Board of Directors. Any number of offices may be held by
the same person.

Section 5.02    Election and Term of Office. The officers of the Corporation shall be elected by the Board of Directors.

Officers shall hold office at the pleasure of the Board of Directors.

Section 5.03    Removal. Any officer may be removed at any time by the Board of Directors with or without cause. Any

vacancy occurring in any office of the Corporation may be filled by the Board of Directors.

Section 5.04    Chairman of the Board. The Chairman of the Board shall preside at all meetings of the Board of Directors

and shall perform such other duties, if any, as from time to time may be assigned to him by the Board of Directors.

16

 
 
Exhibit 3.3

Effective as of February 21, 2023

Section 5.05    Chief Executive Officer. The Chief Executive Officer shall have overall responsibility for the management of
the business and operations of the Corporation and shall see that all orders and resolutions of the Board of Directors are carried into
effect. In the absence of the Chairman of the Board and any Presiding Director, he or she shall preside over meetings of the Board
of Directors. In general, he or she shall perform such duties as from time to time may be assigned to him or her by the Board of
Directors.

Section 5.06    Chief Financial Officer. The Chief Financial Officer shall have general responsibility for the financial affairs

of the Corporation and shall perform such other duties, if any, as from time to time may be assigned to him by the Board of
Directors.

Section 5.07    President. In the absence of the Chief Executive Officer, the President shall have overall responsibility for the
management of the business and operations of the Corporation and shall see that all orders and resolutions of the Board of Directors
are carried into effect. In the absence of the Chairman of the Board, any Presiding Director and the Chief Executive Officer, he or
she shall preside over meetings of the Board of Directors. In general, he or she shall perform such duties as from time to time may
be assigned to him or her by the Board of Directors.

Section 5.08    Executive Vice Presidents or Senior Vice Presidents. The Executive Vice Presidents or Senior Vice
Presidents shall perform such managerial duties and have such authority as may be specified in these Bylaws or by the Board of
Directors, the Chairman of the Board, the Chief Executive Officer or the President. In the absence or disability of the President, the
Executive Vice Presidents or Senior Vice Presidents, in order of seniority established by the Board of Directors or the Chairman of
the Board, shall perform the duties and exercise the powers of the President.

Section 5.09    Vice Presidents. The Vice Presidents shall perform such duties and have such authority as may be specified

in these Bylaws or by the Board of Directors, the Chairman of the Board, the Chief Executive Officer or the President.

Section 5.10    Secretary. The Secretary shall attend all meetings of the Board of Directors and all meetings of the
stockholders and record all the proceedings of the meetings of the stockholders and of the Board of Directors in a book to be kept
for that purpose and shall perform like duties for the standing committees when required. He or she shall give, or cause to be given,
notice of all meetings of the stockholders and special meetings of the Board of Directors, and shall perform such other duties as
may be prescribed by the Board of Directors, the Chairman of the Board, the Chief Executive Officer or the President. He shall
have custody of the corporate seal of the Corporation and he or she, or an Assistant Secretary, shall have authority to affix the same
to any instrument, and when so affixed it may be attested by his or her signature or by the signature of such Assistant Secretary. The
Board of Directors may give general authority to any other officer to affix the seal of the Corporation and to attest the affixing by
his or her signature.

Section 5.11    Assistant Secretaries. The Assistant Secretary or Secretaries shall, in the absence or disability of the
Secretary, perform the duties and exercise the authority of the Secretary, and shall perform such other duties and have such other
authority as the Board of Directors, the Chairman of the Board, the Chief Executive Officer or the President may from time to time
prescribe.

Section 5.12    Treasurer. The Treasurer shall have the custody of the corporate funds and securities and shall keep full and

accurate accounts of receipts and disbursements in books belonging to the Corporation and shall deposit all monies and other
valuable effects in the name

17

Exhibit 3.3

Effective as of February 21, 2023

and to the credit of the Corporation in such depositories as may be designated by the Board of Directors. He or she shall disburse
the funds of the Corporation as may be ordered by the Board of Directors, the Chairman of the Board, or the President, or the Chief
Executive Officer, taking proper vouchers for such disbursements, and shall render to the Board of Directors when the Board of
Directors so requires, an account of all his transactions as Treasurer and of the financial condition of the Corporation.

Section 5.13    Assistant Treasurers. The Assistant Treasurer or Treasurers shall, in the absence or disability of the Treasurer,

perform the duties and exercise the authority of the Treasurer and shall perform such other duties and have such other authority as
the Board of Directors may from time to time prescribe.

ARTICLE 6
INDEMNIFICATION OF DIRECTORS AND OFFICERS

Section 6.01    Indemnification. Any person who was or is a party or is threatened to be made a party to any threatened,

pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that
such person is or was a director or officer of the Corporation, or is or was serving while a director or officer of the Corporation at
the request of the Corporation as a director, officer, employee, agent, fiduciary or other representative of another corporation,
partnership, joint venture, trust, employee benefit plan or other enterprise, shall be indemnified by the Corporation against expenses
(including attorneys’ fees), judgments, fines, excise taxes and amounts paid in settlement actually and reasonably incurred by such
person in connection with such action, suit or proceeding to the full extent permissible under applicable law.

Section 6.02    Advances. To the fullest extent permitted by applicable law as it exists now or is hereafter amended,

expenses (including attorneys’ fees) incurred by a present or former director or officer in defending any civil, criminal,
administrative or investigative action, suit or proceeding for which indemnification is or may be available pursuant to this Article 6
shall be paid by the Corporation in advance of the final disposition of such action, suit or proceeding upon receipt of an undertaking
by or on behalf of the director or officer to repay such amount if it shall ultimately be determined that he or she is not entitled to be
indemnified by the Corporation as authorized in this Article 6. Such expenses (including attorneys’ fees) incurred by other
employees and agents may be so paid upon such terms and conditions, if any, as the Corporation deems appropriate. The Board of
Directors may authorize the Corporation’s counsel to represent a director, officer, employee or agent in any action, suit or
proceeding, whether or not the Corporation is a party to such action, suit or proceeding.

Section 6.03    Procedure. Any indemnification of a director or officer of the Corporation under Section 6.01, or advance of
costs, charges and expenses of a director or officer under Section 6.02, shall be made promptly, and in any event within sixty (60)
days, upon the written request of the director or officer. The right to indemnification or advances as granted by this Article 6 shall
be enforceable, to the fullest extent permitted by law, by the director or officer in any court of competent jurisdiction if the
Corporation denies such request, in whole or in part. Such person’s costs and expenses incurred in connection with successfully
establishing his or her right to indemnification, in whole or in part, in any such action shall also be indemnified by the Corporation,
to the fullest extent permitted by law. It shall be a defense to any such action (other than an action brought to enforce a claim for the
advance of costs, charges and expenses under Section 6.02 where the required undertaking, if any, has been received by the
Corporation) that the claimant has not met the standard of conduct set forth under Delaware law, but the burden of proving such
defense shall be on the Corporation. Neither the failure of the Corporation (including its board of directors or a committee thereof,
its independent legal counsel, and its

18

 
Exhibit 3.3

Effective as of February 21, 2023

stockholders) to have made a determination prior to the commencement of such action that indemnification of the claimant is
proper in the circumstances because he or she has met the applicable standard of conduct under Delaware law, nor the fact that
there has been an actual determination by the Corporation (including its board of directors or a committee thereof, its independent
legal counsel, and its stockholders) that the claimant has not met such applicable standard of conduct, shall be a defense to the
action or create a presumption that the claimant has not met the applicable standard of conduct.

Section 6.04    Other Rights. The indemnification and advancement of expenses provided by this Article 6 shall not be

deemed exclusive of any other rights to which those seeking indemnification or advancement of expenses may be entitled under
any insurance or other agreement, vote of shareholders or disinterested directors or otherwise, both as to actions in their official
capacity and as to actions in another capacity while holding an office, and shall continue as to a person who has ceased to be a
director or officer and shall inure to the benefit of the heirs, executors and administrators of such person.

Section 6.05    Insurance. The Corporation shall have power to purchase and maintain insurance on behalf of any person
who is or was a director, officer, employee or agent of the Corporation or is or was serving at the request of the Corporation as a
director, officer, employee, agent, fiduciary or other representative of another corporation, partnership, joint venture, trust,
employee benefit plan or other enterprise, against any liability asserted against him or her and incurred by him or her in any such
capacity, or arising out of his status as such, whether or not the Corporation would have the power to indemnify him or her against
such liability under the provisions of these Bylaws.

Section 6.06    Modification. The duties of the Corporation to indemnify and to advance expenses to a director or officer

provided in this Article 6 shall constitute a contract between the Corporation, on the one hand, and, on the other hand, each
individual who serves or has served as a director or officer of the Corporation, in consideration of such person’s past or current and
any future performance of services for the Corporation, and pursuant to this Article 6, the Corporation intends to be legally bound
to each such current or former director or officer of the Corporation, the rights conferred under this Article 6 are present contractual
rights, and such rights are fully vested, and shall be deemed to have vested fully, immediately upon such director or officer
commencing service as a director or officer of the Corporation. Neither amendment nor repeal nor modification of any provision of
this Article 6 nor the adoption of any provision of the Corporation’s certificate of incorporation, as amended or restated from time
to time, inconsistent with this Article 6 shall eliminate or reduce the effect of this Article 6 in respect of any act or omission
occurring, or any cause of action or claim that accrues or arises or any state of facts existing, at the time of or before such
amendment, repeal, modification or adoption of an inconsistent provision (even in the case of a proceeding based on such a state of
facts that is commenced after such time). The rights provided by, or granted pursuant to, this Article 6 shall continue
notwithstanding that the person has ceased to be a director or officer of the Corporation and shall inure to the benefit of the estate,
heirs, executors, administrators, legatees and distributees of such person.

ARTICLE 7
CERTIFICATES OF STOCK

Section 7.01    Stock Certificates. Every holder of stock in the Corporation shall be entitled to have a certificate in the form

prescribed by the Board of Directors signed on behalf of the Corporation by the Chairman of the Board or the President or a Vice
President and by the Treasurer or an Assistant Treasurer, or the Secretary or an Assistant Secretary of the Corporation, representing
the number of shares owned by him in the Corporation; provided, that

19

 
Exhibit 3.3

Effective as of February 21, 2023

the board of directors may provide by resolution or resolutions that some or all classes or series of its stock shall be uncertificated
shares. Any or all signatures on the certificate may be a facsimile. In case any officer, transfer agent or registrar who has signed or
whose facsimile signature has been placed upon a certificate shall have ceased to be such officer, transfer agent or registrar before
such certificate is issued, it may be issued by the Corporation with the same effect as if such person were such officer, transfer
agent, or registrar at the date of issue.

Section 7.02    Lost Certificates. The Board of Directors may direct a new certificate or certificates to be issued in place of
any certificate or certificates theretofore issued by the Corporation alleged to have been lost, stolen or destroyed, upon the making
of an affidavit of that fact by the person claiming the certificate of stock to be lost, stolen or destroyed. When authorizing such issue
of a new certificate or certificates, the Board of Directors may, in its discretion and as a condition precedent to the issuance thereof,
require the owner of such lost, stolen or destroyed certificate or certificates, or his legal representative, to advertise the same in such
manner as it shall require and/or to give the Corporation a bond in such sum as it may direct or indemnity against any claim that
may be made against the Corporation with respect to the certificate alleged to have been lost, stolen or destroyed.

Section 7.03    Transfers of Stock. Upon surrender to the Corporation or the transfer agent of the Corporation of a certificate

for shares duly endorsed or accompanied by proper evidence of succession, assignment or authority to transfer, it shall be the duty
of the Corporation to issue a new certificate to the person entitled thereto, cancel the old certificate and record the transaction upon
its books.

Section 7.04    Fixing Record Date. The Board of Directors of the Corporation may fix a record date for the purpose of
determining the stockholders entitled to notice of, or to vote at, any meeting of stockholders or any adjournment thereof, or to
consent to corporate action in writing without a meeting, or to receive payment of any dividend or other distribution or allotment of
any rights, or to exercise any rights in respect of any change, conversion or exchange of stock or for the purpose of any other lawful
action. Such record date shall not precede the date upon which the resolution fixing the record date is adopted by the Board of
Directors and such record date shall not be (i) in the case of such a meeting of stockholders, more than 60 nor less than 10 days
before the date of the meeting of stockholders, or (ii) except for record dates to be fixed in accordance with the provisions of
Section 2.09, in other cases, more than 60 days prior to the payment or allotment or change, conversion or exchange or other action.
A determination of stockholders of record entitled to notice of or to vote at a meeting of stockholders shall apply to any
adjournment of the meeting unless the Board of Directors fixes a new record date for the adjourned meeting. Notwithstanding
anything in this Section 7.04 to the contrary, a record date for determining stockholders entitled to take action by written consent
shall be fixed in accordance with Section 2.09(b) of these Bylaws.

Section 7.05    Registered Stockholders. The Corporation shall be entitled to recognize the exclusive right of a person
registered on its books as the owner of stock to receive dividends and to vote as such owner, and shall be entitled to hold liable for
calls and assessments a person registered on its books as the owner of stock, and shall not be bound to recognize any equitable or
other claim to, or interest in, such stock on the part of any other person, whether or not it shall have express or other notice thereof,
except as otherwise provided by the laws of Delaware.

Section 8.01    Amendments. These Bylaws may be altered, amended or repealed, and new Bylaws may be adopted, by the

stockholders or by the Board of Directors at any regular

ARTICLE 8
MISCELLANEOUS

20

 
Exhibit 3.3

Effective as of February 21, 2023

meeting of the stockholders or of the Board of Directors or at any special meeting of the stockholders or of the Board of Directors if
notice of such alteration, amendment, repeal or adoption of new Bylaws be contained in the notice of such special meeting.

Section 8.02    Exclusive Jurisdiction of Delaware Courts or the United States Federal District Courts. Unless the
Corporation consents in writing to the selection of an alternative forum, the sole and exclusive forum for (a) any derivative action
or proceeding brought on behalf of the Corporation, (b) any action asserting a claim of breach of a fiduciary duty owed by any
director or officer or other employee of the Corporation to the Corporation or the Corporation’s stockholders, (c) any action
asserting a claim against the Corporation or any director or officer or other employee of the Corporation arising pursuant to any
provision of the DGCL or the Certificate of Incorporation or these Bylaws (in each case, as they may be amended from time to
time) or (d) any action asserting a claim against the Corporation or any director or officer or other employee of the Corporation
governed by the internal affairs doctrine shall be a state court located within the State of Delaware (or, if no state court located
within the State of Delaware has jurisdiction, the federal district court for the District of Delaware); provided, however, that this
sentence will not apply to any causes of action arising under the Securities Act of 1933, as amended, or the Exchange Act, or to any
claim for which the federal courts have exclusive jurisdiction. Unless the Corporation consents in writing to the selection of an
alternative forum, the federal district courts of the United States of America shall be the sole and exclusive forum for resolving any
complaint asserting a cause of action arising under the Securities Act of 1933, as amended, the Exchange Act, or the respective
rules and regulations promulgated thereunder. To the fullest extent permitted by law, any person or entity purchasing or otherwise
acquiring any interest in shares of capital stock of the Corporation shall be deemed to have notice of and consented to the
provisions of this

Section 8.03    Severability. If any provision or provisions of these Bylaws shall be held to be invalid, illegal or

unenforceable for any reason whatsoever: (a) the validity, legality and enforceability of the remaining provisions of these Bylaws
(including, without limitation, each portion of any paragraph containing any such provision held to be invalid, illegal or
unenforceable, that is not itself held to be invalid, illegal or unenforceable) shall not in any way be affected or impaired thereby;
and (b) to the fullest extent possible, the provisions of these Bylaws (including, without limitation, each such portion of any
paragraph containing any such provision held to be invalid, illegal or unenforceable) shall be construed so as to give effect to the
intent manifested by the provision held invalid, illegal or unenforceable.

21

Exhibit 4.4

Description of the Company’s Common Stock Registered
Under Section 12 of the Exchange Act

The following is a description of the common stock of Integra LifeSciences Holdings Corporation (the “Company”). The description does not purport to be
complete and is subject to and qualified in its entirety by reference to the Company’s amended and restated certificate of incorporation, or the certificate of
incorporation, and its third amended and restated by-laws, or the bylaws) each of which are filed as exhibits to this Annual Report on Form 10-K, and to the
provisions of the Delaware General Corporation Law (“DGCL”).

General Matters

Authorized Shares

The Company’s authorized capital stock consists of 255,000,000 shares of stock, of which 240,000,000 shares are designated as common stock, par value
$0.01 per share, and 15,000,000 shares are designated as preferred stock, no par value. As of December 31, 2022, we had 90,476,671 shares of common stock
outstanding, 6,822,864 shares were designated as treasury stock, and no shares of preferred stock outstanding.

Dividends

Subject to preferences that may apply to shares of preferred stock outstanding at the time, the holders of outstanding shares of common stock are entitled to
receive dividends out of assets legally available therefor at such times and in such amounts as the board of directors may from time to time determine.
However, our senior credit facility limits the amount of dividends that we may pay. Any future determinations to pay cash dividends on our common stock
will be at the discretion of our board of directors and will depend upon our financial condition, results of operations, cash flows and other factors that our
board of directors deems relevant.

Voting Rights

Each stockholder is entitled to one vote in person or by proxy for each share of the capital stock having voting power held by such stockholder. Stockholders
do not have cumulative voting rights. The Company’s board of directors is not classified and each director is elected annually. The voting standard for the
election of directors is a majority of votes cast in uncontested elections. In contested elections where the number of nominees exceeds the number of directors
to be elected, the vote standard is a plurality of the votes cast. Holders of a majority of the outstanding shares of common stock entitled to vote in any election
of directors may elect all of the directors standing for election.

Preemptive or Similar Rights

Our common stock is not entitled to preemptive rights and is not subject to conversion or redemption.

Right to Receive Liquidation Distributions

Upon the occurrence of a liquidation, dissolution or winding-up, the holders of shares of common stock would be entitled to share ratably in the distribution
of all of our assets remaining available for distribution after satisfaction of all its liabilities and the payment of the liquidation preference of any outstanding
preferred stock.

Stock Exchange

Our common stock is traded on the Nasdaq Global Select Market under the symbol “IART”.

Preferred Stock

Exhibit 4.4

The Company’s Board of Directors has the authority to issue up to 15,000,000 shares of Preferred Stock from time to time in one or more series and with such
rights and preferences as determined by the Board with respect to each series. The issuance of preferred stock could have the effect of decreasing the market
price of our common stock and could adversely affect the voting and other rights of holders of common stock.

Statutory Business Combination Provision

As a Delaware corporation, we are subject to Section 203 of the General Corporation Law of the State of Delaware, or DGCL. In general, Section 203 of the
DGCL prevents an “interested stockholder,” which is defined generally as a person owning 15% or more of a Delaware corporation’s outstanding voting stock
or any affiliate or associate of that person, from engaging in a broad range of “business combinations” with the corporation for three years following the date
that person became an interested stockholder unless:

•

•

•

before that person became an interested stockholder, the board of directors of the corporation approved the transaction in which that person became
an interested stockholder or approved the business combination;

on completion of the transaction that resulted in that person’s becoming an interested stockholder, that person owned at least 85% of the voting stock
of the corporation outstanding at the time the transaction commenced, other than stock held by (1) directors who are also officers of the corporation
or (2) any employee stock plan that does not provide employees with the right to determine confidentially whether shares held subject to the plan will
be tendered in a tender or exchange offer; or

following the transaction in which that person became an interested stockholder, both the board of directors of the corporation and the holders of at
least two-thirds of the outstanding voting stock of the corporation not owned by that person approve the business combination.

Under Section 203 of the DGCL, the restrictions described above also do not apply to specific business combinations proposed by an interested stockholder
following the announcement or notification of designated extraordinary transactions involving the corporation and a person who had not been an interested
stockholder during the previous three years or who became an interested stockholder with the approval of a majority of the corporation’s directors, if a
majority of the directors who were directors prior to any person’s becoming an interested stockholder during the previous three years, or were recommended
for election or elected to succeed those directors by a majority of those directors, approve or do not oppose that extraordinary transaction.

Anti-Takeover Effects of our Certificate of Incorporation and our Bylaws

Some of the provisions of our certificate of incorporation and bylaws discussed below may have the effect, either alone or in combination with the provisions
of our certificate of incorporation discussed above and Section 203 of the DGCL, of making more difficult or discouraging a tender offer, proxy contest,
merger or other takeover attempt that our board of directors opposes but that a stockholder might consider to be in its best interest.

Special Meetings of Stockholders. Our bylaws provide that a special meeting of our stockholders may only be called by (i) the chairman of our board of
directors, (ii) the president or (iii) our board of directors.

Stockholder Action by Written Consent. Our stockholders may act by written consent without a meeting, subject to the requirements in our bylaws for setting a
record date for the written consent. Any stockholder seeking to have the stockholders authorize or take corporate action must request that our Board of
Directors fix a record date. Such notice must include the same information required for a stockholder proposal and be submitted to our Board of Directors as
described in our bylaws.

Vacancies on the Board of Directors. Our certificate of incorporation provides that the number of directors will be fixed exclusively by, and may be increased
or decreased exclusively by, our board of directors from time to time, but will not be less than three nor more than thirteen. Our bylaws provide that vacancies
on the board of directors arising through death, resignation, retirement or removal shall be filled only by a majority of the directors then in office whether or
not the remaining directors constitute a quorum. These provisions will prevent our stockholders from removing incumbent directors without cause and filling
the resulting vacancies with their own nominees.

Our certificate of incorporation provides that the number of directors will be fixed exclusively by, and may be increased or decreased exclusively by, our
board of directors from time to time, but will not be less than three nor more than thirteen. Our certificate of incorporation provides that directors may be
removed only by the Delaware Chancery Court under Section 225(c) of the DGCL or for cause (as such term is defined in our certificate of incorporation) as
determined by a vote of at least 80% of the voting power of our outstanding voting stock. A vacancy on our board of directors may be filled by a vote of a
majority of

Exhibit 4.4

the directors in office, and a director appointed to fill a vacancy serves for the remainder of the term of the class of directors in which the vacancy occurred.

Advance Notice Requirements for Stockholder Proposals and Director Nominations. Our bylaws contain provisions requiring that advance notice be delivered
to us of any business to be brought by a stockholder before an annual meeting of stockholders and providing for certain procedures to be followed by
stockholders in nominating persons for election to our board of directors. Generally, the advance notice provisions provide that the stockholder must give
written notice to our Secretary not less than 90 days nor more than 120 days prior to the anniversary date of the immediately preceding annual meeting, except
that in the event that the annual meeting is called for a date that is more than 30 days before or more than 60 days after such anniversary date, notice by the
stockholder to be timely must be so delivered not later than the 90th day prior to the date of such annual meeting (or, if later, then the 10th day following the
day on which public disclosure of the date of such annual meeting was first made). The notice must set forth specific information regarding that stockholder
and that business or director nominee, as described in our bylaws.

Amendment of Certain Provisions of the Certificate of Incorporation and Bylaws. Under the DGCL, the stockholders of a corporation have the right to adopt,
amend or repeal the bylaws and, with the approval of the board of directors, the certificate of incorporation of a corporation. In addition, if the certificate of
incorporation so provides, the bylaws may be adopted, amended or repealed by the board of directors. Our Certificate provides that the bylaws may be
amended or repealed by our board of directors. Our certificate of incorporation and bylaws also confer on our board of directors the power to adopt, amend or
repeal our amended and restated bylaws with the affirmative vote of a majority of the directors then in office.

Forum Selection. Our bylaws provide, unless we consent in writing to the selection of an alternative forum, that the sole and exclusive forum for (a) any
derivative action or proceeding brought on our behalf, (b) any action asserting a claim of breach of a fiduciary duty owed by any of our directors, officers or
other employees to us or our stockholders, (c) any action asserting a claim against us or any of our directors, officers or other employees arising pursuant to
any provision of the DGCL, our certificate of incorporation or our bylaws (in each case, as they may be amended from time to time) or (d) any action
asserting a claim against us or any of our directors, officers or other employees governed by the internal affairs doctrine, will be a state court located within
the State of Delaware (or, if no state court located within the State of Delaware has jurisdiction, the federal district court for the District of Delaware). Any
person that purchases or otherwise acquires an interest in our stock will be deemed to have notice of and agree to comply with the foregoing provisions.

Our bylaws provide that a state court of the State of Delaware (or, if no state court located within the State of Delaware has jurisdiction, the federal district
court for the District of Delaware) shall be the sole and exclusive forum for: (i) any derivative action or proceeding brought on behalf of Integra; (ii) any
action asserting a claim of breach of a fiduciary duty owed by any director or officer of Integra to Integra or the stockholders; (iii)  any action asserting a claim
against Integra arising pursuant to any provision of the DGCL, our certificate of incorporation or our bylaws (as each may be amended, from time to time); or
(iv) any other action asserting a claim against Integra or any director or officer of Integra that is governed by or subject to the internal affairs doctrine for
choice of law purposes. However, the forum selection provision does not apply to any claims, actions or proceedings arising under the Securities Act of 1933,
as amended, which we refer to as the “Securities Act,” or the Exchange Act. Unless we consent in writing to the selection of an alternative forum, the federal
district courts of the United States of America shall be the sole and exclusive forum for resolving any complaint asserting a cause of action arising under the
Securities Act of 1933, as amended, the Exchange Act, or the respective rules and regulations promulgated thereunder. Any person or entity purchasing or
otherwise acquiring any interest in shares of our stock will be deemed to have notice of and consented to the exclusive forum provisions in our bylaws.

Preferred Stock. As discussed above under “General Matters—Preferred Stock,” our certificate of incorporation authorizes our board of directors, without the
approval of our stockholders, to provide for the issuance of all or any shares of our preferred stock in one or more series and to determine the designation,
powers, preferences and relative, participating, optional or other special rights, and the qualifications, limitations or restrictions applicable to any of those
rights, including dividend rights, voting rights, conversion or exchange rights, terms of redemption and liquidation preferences, of each series. The issuance of
shares of our preferred stock, or the issuance of rights to purchase shares of preferred stock, could be used to discourage an unsolicited acquisition proposal.
In addition, under some circumstances, the issuance of preferred stock could adversely affect the voting power of our common stockholders.

Exhibit 10.3(h)

THIS RESTRICTED STOCK AGREEMENT (the “Award Agreement”), dated as of [ ] (the “Award Date”), is

made by and between Integra LifeSciences Holdings Corporation, a Delaware corporation (the “Company”), and [ ], a non-
employee director of the Company, hereinafter referred to as the “Participant”:

RESTRICTED STOCK AGREEMENT

WHEREAS, the Company maintains the Integra LifeSciences Holdings Corporation 2003 Equity Incentive Plan, as

amended (the “Plan”), and wishes to carry out the Plan, the terms of which are hereby incorporated by reference and made part of
this Award Agreement; and

NOW, THEREFORE, in consideration of the various covenants herein contained, and intending to be legally

bound hereby, the parties hereto agree as follows:

ARTICLE I.
DEFINITIONS

shall include the feminine and neuter, and the singular the plural, where the context so indicates.

Capitalized terms not otherwise defined below shall have the meaning set forth in the Plan. The masculine pronoun

issued under this Award Agreement and subject to the Restrictions imposed hereunder.

Section 1.1    Restricted Stock. “Restricted Stock” shall mean [ ] shares of Common Stock of the Company

Section 1.2    Restrictions. “Restrictions” shall mean the forfeiture and transferability restrictions imposed

upon Restricted Stock under the Plan and this Award Agreement.

Section 1.3    Rule 16b-3. “Rule 16b-3” shall mean that certain Rule 16b-3 under the Exchange Act, as such

Rule may be amended from time to time.

Section 1.4    Secretary. “Secretary” shall mean the Secretary of the Company.

Section 1.5    Termination of Service. “Termination of Service” shall mean the time when the Participant

ceases to provide services to the Company and its Related Corporations and Affiliates as an employee or Associate for any
reason with or without cause, including, but not by way of limitation, a termination by resignation, discharge, death, or
Disability, but excluding a termination where the Participant is simultaneously reemployed by, or remains employed by, or
continues to provide services to, the Company and/or one or more of its Related Corporations and Affiliates or a successor
entity thereto.

subject to the Restrictions by reason of Section 3.2.

Section 1.6    Vested Shares. “Vested Shares” shall mean the shares of Restricted Stock which are no longer

Award Date.

Section 1.7    Vesting Date. “Vesting Date” shall mean each of the twelve-month anniversary date of the

| ||

 
Exhibit 10.3(h)

ARTICLE II.
ISSUANCE OF RESTRICTED STOCK

Section 2.1    Issuance of Restricted Stock. On the date hereof the Company issues to the Participant the

Restricted Stock subject to the Restrictions and other conditions set forth in this Award Agreement. The Company shall
cause the Restricted Stock to be issued in the name of the Participant or held in book entry form, but if a stock certificate is
issued it shall be delivered to and held in custody by the Company until the Restrictions lapse or such Restricted Stock is
forfeited. As a further condition to the Company’s obligations under this Award Agreement, the Participant’s spouse, if any,
shall execute and deliver to the Company the Consent of Spouse attached hereto as Exhibit A.

Section 2.2    Restrictions. Until vested pursuant to Section 3.2, the Restricted Stock shall be subject to

forfeiture as provided in Section 3.1 and may not be sold, assigned, transferred, pledged, or otherwise encumbered or
disposed of.

Section 2.3    Voting and Dividend Rights. The Participant, shall have all the rights of a stockholder with

respect to his Restricted Stock, including the right to vote the Restricted Stock, except that the Participant shall have the
right to receive all dividends or other distributions paid or made with respect to only those outstanding vested shares of
Common Stock.

ARTICLE III.
RESTRICTIONS

Section 3.1    Forfeiture. Upon the Participant’s Termination of Service other than by (i) death or Disability

or (ii) a Qualifying Termination upon a Change in Control as further described in Section 3.2, the Participant’s rights in
Restricted Stock that has not yet vested pursuant to Section 3.2 shall lapse, and such Restricted Stock shall be surrendered to
the Company without consideration (and, in the event of certificates representing such Restricted Stock are held by the
Company, such Restricted Stock shall be so transferred without any further action by the Participant).

Section 3.2    Termination of Restrictions. The Restrictions shall terminate and lapse, and such shares shall
vest  in  the  Participant  and  become  Vested  Shares  on  the  Vesting  Date  as  provided  in  Section  3.3,  provided  that  the
Participant has continued to serve as an employee or an Associate from the Award Date to and including such Vesting Date.
Notwithstanding  the  foregoing,  (i)  in  the  event  that  a  Change  in  Control  occurs  and  the  Participant  incurs  a  Qualifying
Termination  on  or  within  twelve  (12)  months  following  the  date  of  such  Change  in  Control  or  (ii)  in  the  event  of  the
Participant’s death or Disability, all Restrictions shall lapse and all Restricted Stock shall become Vested Shares upon such
Qualifying Termination, death or Disability.

Section 3.3    Lapse of Restrictions. All of the shares of Restricted Stock shall become Vested Shares on the
Vesting Date. On the Vesting Date, the Company shall issue new certificates evidencing such Vested Shares and deliver such
certificates to the Participant or his legal representative, or record such Vested Shares in book entry form, free from the
legend provided for in Section 4.2 and any of the other Restrictions; provided, however, such certificates shall bear any
other legends and such book entry accounts shall be subject to any other restrictions as the Company may determine are
required to comply with Section 4.6. Such Vested Shares shall cease to be considered Restricted Stock subject to the terms
and conditions of this Award Agreement. Notwithstanding the foregoing, no such new certificate shall be delivered to the

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Exhibit 10.3(h)

Participant or his legal representative unless and until the Participant or his legal representative shall have paid to the
Company in cash or by check the full amount of all federal, state and local withholding or other employment taxes
applicable to the taxable income of the Participant resulting from the lapse of the Restrictions

Section 3.4    Clawback. Notwithstanding  anything  contained  in  the  Plan  or  the  Award  Agreement  to  the
contrary,  the  Restricted  Stock  shall  be  subject  to  the  provisions  of  any  clawback,  repayment  or  recapture  policy
implemented  by  the  Company,  including  any  such  policy  adopted  to  comply  with  applicable  law  (including  without
limitation the Dodd-Frank Wall Street Reform and Consumer Protection Act) or securities exchange listing standards and
any  rules  or  regulations  promulgated  thereunder,  to  the  extent  set  forth  in  such  policy  and/or  in  any  notice  or  agreement
relating to the Restricted Stock under the Plan.

ARTICLE IV.
MISCELLANEOUS

Section 4.1    No Additional Rights. Nothing in this Award Agreement or in the Plan shall confer upon any
person any right to a position as an Associate or continued employment by the Company or any of its Related Corporations
or Affiliates or affect in any way the right of any of the foregoing to terminate the services of an individual at any time.

Section 4.2    Legend. Any certificates representing shares of Restricted Stock issued pursuant to this Award

Agreement may include, until all Restrictions lapse and new certificates are issued pursuant to Section 3.3, bear the
following legend:

    THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN VESTING
REQUIREMENTS AND MAY BE SUBJECT TO FORFEITURE UNDER THE TERMS OF THAT CERTAIN
RESTRICTED STOCK AGREEMENT BY AND BETWEEN INTEGRA LIFESCIENCES HOLDINGS CORPORATION
AND THE HOLDER OF THE SECURITIES. PRIOR TO VESTING OF OWNERSHIP IN THE SECURITIES, THEY
MAY NOT BE, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, OR OTHERWISE ENCUMBERED OR DISPOSED
OF UNDER ANY CIRCUMSTANCES. COPIES OF THE ABOVE REFERENCED AGREEMENT ARE ON FILE AT
THE OFFICES OF THE CORPORATION AT 1100 CAMPUS DRIVE, PRINCETON, NEW JERSEY 08540.

Section 4.3    Tax Withholding. On the Vesting Date, the Company shall notify the Participant of the

amount of tax which must be withheld by the Company under all applicable federal, state and local tax laws. Subject to any
applicable legal conditions or restrictions, the Company shall withhold from the shares of Restricted Stock a number of
whole shares of common stock having a fair market value, determined as of the Vesting Date, not in excess of the minimum
tax required to be withheld by law.

Section 4.4    Notices. Any notice to be given under the terms of this Award Agreement to the Company

shall be addressed to the Company in care of its Secretary, and any notice to be given to the Participant shall be addressed to
him at the address given beneath his signature hereto. By a notice given pursuant to this Section 4.4, either party may
hereafter designate a different address for notices to be given to it or him. Any notice which is required to be given to the
Participant shall, if the Participant is then deceased, be given to the Participant’s personal representative if such
representative has previously informed the Company of his status and address by written notice under this Section 4.4. Any
notice shall have been deemed duly given when enclosed in a

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Exhibit 10.3(h)

properly sealed envelope or wrapper addressed as aforesaid, deposited (with postage prepaid) in a post office or branch post
office regularly maintained by the United States Postal Service.

Section 4.5    Titles. Titles are provided herein for convenience only and are not to serve as a basis for

interpretation or construction of this Award Agreement.

Section 4.6    Conformity to Securities Laws. This Award Agreement is intended to conform to the extent
necessary with all provisions of the Securities Act and the Exchange Act and any and all regulations and rules promulgated
by the Securities and Exchange Commission thereunder, including without limitation Rule 16b-3. Notwithstanding anything
herein to the contrary, this Award Agreement shall be administered, and the Restricted Stock shall be issued, only in such a
manner as to conform to such laws, rules and regulations. To the extent permitted by applicable law, this Award Agreement
and the Restricted Stock issued hereunder shall be deemed amended to the extent necessary to conform to such laws, rules
and regulations.

parties hereto which specifically states that it is amending this Award Agreement.

Section 4.7    Amendment. This Award Agreement may be amended only by a writing executed by the

Section 4.8    Governing Law. The laws of the State of Delaware shall govern the interpretation, validity,

administration, enforcement and performance of the terms of this Award Agreement regardless of the law that might be
applied under principles of conflicts of laws.

*****

IN WITNESS HEREOF, this Award Agreement has been executed and delivered by the parties hereto.

                                INTEGRA LIFESCIENCES
THE PARTICIPANT                        HOLDINGS CORPORATION

                                By                    
[ ]                Name:
                                Title:

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Exhibit 10.3(h)

| ||

Exhibit 10.3(i)

RESTRICTED STOCK AGREEMENT

THIS RESTRICTED STOCK AGREEMENT (the “Award Agreement”), dated as of [ ] (the “Award Date”), is
made by and between Integra LifeSciences Holdings Corporation, a Delaware corporation (the “Company”), and [ ], an employee
of the Company (or one or more of its Related Corporations or Affiliates), hereinafter referred to as the “Participant”:

WHEREAS, the Company maintains the Integra LifeSciences Holdings Corporation Fifth Amended and Restated
2003 Equity Incentive Plan, as amended (the “Plan”), and wishes to carry out the Plan, the terms of which are hereby incorporated
by reference and made part of this Award Agreement; and

bound hereby, the parties hereto agree as follows:

NOW, THEREFORE, in consideration of the various covenants herein contained, and intending to be legally

Capitalized terms not otherwise defined below shall have the meaning set forth in the Plan. The masculine pronoun

shall include the feminine and neuter, and the singular the plural, where the context so indicates.

ARTICLE I.
DEFINITIONS

Section 1.1    Restricted Stock. “Restricted Stock” shall mean 

[ ] shares of Common Stock of the Company issued under this Award Agreement and subject to the Restrictions imposed
hereunder.

Section 1.2    Restrictions. “Restrictions” shall mean the forfeiture and transferability restrictions imposed upon

Restricted Stock under the Plan and this Award Agreement.

Section 1.3    Rule 16b-3. “Rule 16b-3” shall mean that certain Rule 16b-3 under the Exchange Act, as such Rule

may be amended from time to time.

Section 1.4    Secretary. “Secretary” shall mean the Secretary of the Company.

Section 1.5    Termination of Service. “Termination of Service” shall mean the time when the Participant ceases

to provide services to the Company and its Related Corporations and Affiliates as an employee or Associate for any
reason with or without cause, including, but not by way of limitation, a termination by resignation, discharge, death, or
Disability, but excluding a termination where the Participant is simultaneously reemployed by, or remains employed by,
or continues to provide services to, the Company and/or one or more of its Related Corporations and Affiliates or a
successor entity thereto.

Section 1.6    Vested Shares. “Vested Shares” shall mean the shares of Restricted Stock which are no longer

subject to the Restrictions by reason of Section 3.2.

Section 1.7    Vesting Date. “Vesting Date” shall mean each of the first, second and third anniversaries of the

Award Date.

Exhibit 10.3(i)

ARTICLE II.
ISSUANCE OF RESTRICTED STOCK

Section 2.1    Issuance of Restricted Stock. On the date hereof the Company issues to the Participant the
Restricted Stock subject to the Restrictions and other conditions set forth in this Award Agreement. The Company shall
cause the Restricted Stock to be issued in the name of the Participant or held in book entry form, but if a stock certificate
is issued it shall be delivered to and held in custody by the Company until the Restrictions lapse or such Restricted Stock
is forfeited. As a further condition to the Company’s obligations under this Award Agreement, the Participant’s spouse, if
any, shall execute and deliver to the Company the Consent of Spouse attached hereto as Exhibit A.

Section 2.2    Restrictions. Until vested pursuant to Section 3.2, the Restricted Stock shall be subject to forfeiture

as provided in Section 3.1 and may not be sold, assigned, transferred, pledged, or otherwise encumbered or disposed of.

Section 2.3    Voting and Dividend Rights. The Participant shall have all the rights of a stockholder with respect
to his Restricted Stock, including the right to vote the Restricted Stock, except that the Participant shall have the right to
receive all dividends or other distributions paid or made with respect to only those outstanding vested shares of Common
Stock.

ARTICLE III.
RESTRICTIONS

Section 3.1    Forfeiture. Upon the Participant’s Termination of Service other than by reason of death or
Disability, the Participant’s rights in Restricted Stock that has not yet vested pursuant to Section 3.2 shall lapse, and such
Restricted Stock shall be surrendered to the Company without consideration (and, in the event of certificates representing
such Restricted Stock are held by the Company, such Restricted Stock shall be so transferred without any further action
by the Participant).

Section 3.2    Termination of Restrictions. The Restrictions shall terminate and lapse, and such shares shall vest

in the Participant and become Vested Shares on each Vesting Date as provided in Section 3.3, provided that the
Participant has continued to serve as an employee or an Associate from the Award Date to and including such Vesting
Date. Notwithstanding the foregoing, (i) in the event that a Change in Control occurs and the Participant incurs a
Qualifying Termination on or within twelve (12) months following the date of such Change in Control or (ii) in the event
of the Participant’s death or Disability, all Restrictions shall lapse and all Restricted Stock shall become Vested Shares
upon such Qualifying Termination, death or Disability.

Section 3.3    Lapse of Restrictions. Thirty-three percent (33%) of the shares of Restricted Stock shall become

Vested Shares on each of the first two Vesting Dates, and thirty-four percent (34%) of the shares of Restricted Stock shall
become Vested Shares on the third Vesting Date. On each Vesting Date, the Company shall issue new certificates
evidencing the Vested Shares or record such Vested Shares in book entry form, free from the legend provided for in
Section 4.2 and any of the other Restrictions; provided, however, such

Exhibit 10.3(i)

certificates shall bear any other legends and such book entry accounts shall be subject to any other restrictions as the
Company may determine are required to comply with Section 4.6. Such Vested Shares shall cease to be considered
Restricted Stock subject to the terms and conditions of this Award Agreement. Notwithstanding the foregoing, no such
new certificate shall be delivered to the Participant or his legal representative unless and until the Participant or his legal
representative shall have satisfied the full amount of all federal, state and local withholding or other employment taxes
applicable to the taxable income of the Participant resulting from the lapse of the Restrictions in accordance with Section
4.3.

Section  3.4        Clawback.  Notwithstanding  anything  contained  in  the  Plan  or  the  Award  Agreement  to  the
contrary,  the  Restricted  Stock  shall  be  subject  to  the  provisions  of  any  clawback,  repayment  or  recapture  policy
implemented  by  the  Company,  including  any  such  policy  adopted  to  comply  with  applicable  law  (including  without
limitation the Dodd-Frank Wall Street Reform and Consumer Protection Act) or securities exchange listing standards and
any rules or regulations promulgated thereunder, to the extent set forth in such policy and/or in any notice or agreement
relating to the Restricted Stock under the Plan.

ARTICLE IV.
MISCELLANEOUS

Section 4.1    No Additional Rights. Nothing in this Award Agreement or in the Plan shall confer upon any

person any right to a position as an Associate or continued employment by the Company or any of its Related
Corporations or Affiliates or affect in any way the right of any of the foregoing to terminate the services of an individual
at any time.

Section 4.2    Legend. Any certificates representing shares of Restricted Stock issued pursuant to this Award

Agreement shall, until all Restrictions lapse and new certificates are issued pursuant to Section 3.3, bear the following
legend:

    THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN VESTING
REQUIREMENTS AND MAY BE SUBJECT TO FORFEITURE UNDER THE TERMS OF THAT CERTAIN
RESTRICTED STOCK AGREEMENT BY AND BETWEEN INTEGRA LIFESCIENCES HOLDINGS CORPORATION
AND THE HOLDER OF THE SECURITIES. PRIOR TO VESTING OF OWNERSHIP IN THE SECURITIES, THEY
MAY NOT BE, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, OR OTHERWISE ENCUMBERED OR DISPOSED
OF UNDER ANY CIRCUMSTANCES. COPIES OF THE ABOVE REFERENCED AGREEMENT ARE ON FILE AT
THE OFFICES OF THE CORPORATION AT 1100 CAMPUS ROAD, PRINCETON, NEW JERSEY 08540.

Section 4.3    Tax Withholding. On each Vesting Date, the Company shall notify the Participant of the amount of

tax which must be withheld by the Company under all applicable federal, state and local tax laws. Subject to any
applicable legal conditions or restrictions, the Company shall withhold from the shares of Restricted Stock a number of
whole shares of common stock

Exhibit 10.3(i)

having a fair market value, determined as of each Vesting Date, not in excess of the minimum of tax required to be
withheld by law.

Section 4.4    Notices. Any notice to be given under the terms of this Award Agreement to the Company shall be
addressed to the Company in care of its Secretary, and any notice to be given to the Participant shall be addressed to him
at the address given beneath his signature hereto. By a notice given pursuant to this Section 4.4, either party may
hereafter designate a different address for notices to be given to it or him. Any notice which is required to be given to the
Participant shall, if the Participant is then deceased, be given to the Participant’s personal representative if such
representative has previously informed the Company of his status and address by written notice under this Section 4.4.
Any notice shall have been deemed duly given when enclosed in a properly sealed envelope or wrapper addressed as
aforesaid, deposited (with postage prepaid) in a post office or branch post office regularly maintained by the United
States Postal Service.

Section 4.5    Titles. Titles are provided herein for convenience only and are not to serve as a basis for

interpretation or construction of this Award Agreement.

Section 4.6    Conformity to Securities Laws. This Award Agreement is intended to conform to the extent

necessary with all provisions of the Securities Act and the Exchange Act and any and all regulations and rules
promulgated by the Securities and Exchange Commission thereunder, including without limitation Rule 16b-3.
Notwithstanding anything herein to the contrary, this Award Agreement shall be administered, and the Restricted Stock
shall be issued, only in such a manner as to conform to such laws, rules and regulations. To the extent permitted by
applicable law, this Award Agreement and the Restricted Stock issued hereunder shall be deemed amended to the extent
necessary to conform to such laws, rules and regulations.

Section 4.7    Amendment. This Award Agreement may be amended only by a writing executed by the parties

hereto which specifically states that it is amending this Award Agreement.

Section  4.8        Governing  Law.  The  laws  of  the  State  of  Delaware  shall  govern  the  interpretation,  validity,
administration, enforcement and performance of the terms of this Award Agreement regardless of the law that might be
applied under principles of conflicts of laws.

Section 4.9 Electronic Delivery and Acceptance. Participant hereby consents to receive the Notice of Grant of Award and
Award Agreement and any other documents related to this award or future awards by electronic delivery and to accept this or future
awards through an on-line or electronic system established and maintained by the Company or another third party designated by the
Company.  Participant  acknowledges  that  he/she  has  read,  understand  and  agrees  to  the  terms  of  the  Notice  of  Grant  of  Award,
Award Agreement and Plan. By clicking the “ACCEPT” button on E*TRADE’s on-line grant agreement response page, it will act
as  Participant’s  electronic  signature  to  these  documents  and  will  result  in  a  contract  between  Integra  LifeSciences  Holdings
Corporation  and  the  Participant  with  respect  to  the  award.  In  the  event  of  any  conflict  or  inconsistency  between  the  terms  and
conditions of this Award Agreement or any other contracts or documents related to this award, on the one hand, and any terms or

Exhibit 10.3(i)

conditions set forth in the Plan, the terms and conditions set forth in the Plan shall prevail.

*****

IN WITNESS HEREOF, this Award Agreement has been executed and delivered by the parties hereto.

                                INTEGRA LIFESCIENCES
THE PARTICIPANT                        HOLDINGS CORPORATION

                                By                
[ ]                        Name:
                                Title:

        
                        
Exhibit 10.3(j)

PERFORMANCE STOCK AGREEMENT

    THIS PERFORMANCE STOCK AGREEMENT (the “Award Agreement”), dated as of [          ] (the “Award Date”), is made
by and between Integra LifeSciences Holdings Corporation, a Delaware corporation (the “Company”), and [          ], an employee of
the Company (or one or more of its Related Corporations or Affiliates), hereinafter referred to as the “Participant.”
    WHEREAS, the Company has determined to grant to the Participant an award of Performance Stock (as defined below), on the
terms set forth herein, under the Integra LifeSciences Holdings Corporation Fifth Amended and Restated 2003 Equity Incentive
Plan, as amended (the “Plan”), the terms of which are hereby incorporated by reference and made part of this Award Agreement.

    NOW, THEREFORE, in consideration of the various covenants herein contained, and intending to be legally bound hereby, the
parties hereto agree as follows:

ARTICLE I.
DEFINITIONS

    Capitalized terms not otherwise defined below shall have the meaning set forth in the Plan. The masculine pronoun shall include
the feminine and neuter, and the singular the plural, where the context so indicates.

Section 1.1    Annual Organic Revenue. “Annual Organic Revenue” shall mean the Company’s gross revenue with respect

to an applicable fiscal year excluding the effects of currency exchange rates, acquired revenues, product discontinuances and
divestitures.

Section 1.2    Catch-Up Performance Goal. “Catch-Up Performance Goal” shall mean the specific goal determined by the

Committee, as specified in Exhibit A.

Section 1.3    Catch-Up Shares. “Catch-Up Shares” shall have the meaning as specified in Exhibit A.

Section 1.4    Change in Control. “Change in Control” shall have the meaning set forth in the Plan.

Section 1.5    Chief Human Resources Officer. “Chief Human Resources Officer” shall mean the Chief Human Resources

Officer of the Company.

Section 1.6    Good Reason. “Good Reason” shall have the meaning set forth in the Plan.

Section 1.7    Performance Goals. “Performance Goals” shall mean the specific goal or goals determined by the

Committee, as specified in Exhibit A, including (if applicable) the Catch-Up Performance Goal.

Section 1.8    Performance Period. “Performance Period” shall mean the period or periods of time that the Performance

Goals must be met, as specified in Exhibit A.

Section 1.9    Performance-Vest. “Performance-Vest” shall mean that, with respect to a share of Performance Stock, the

applicable Performance Goal has been achieved.

Section 1.10    Performance Vesting Percentage. “Performance Vesting Percentage” shall mean the percentage determined

in accordance with Exhibit A attached hereto, which is a function of whether and to what extent the Performance Goals are
achieved during the Performance Period.

Section 1.11    Qualifying Termination. “Qualifying Termination” shall mean a Termination of Service by the Company

without Cause or by the Participant for Good Reason.

Section 1.12    Rule 16b-3. “Rule 16b-3” shall mean that certain Rule 16b-3 under the Exchange Act, as such Rule may be

amended from time to time.

Section 1.13    Termination of Service. “Termination of Service” shall mean the time when the Participant ceases to

provide services to the Company and its Related Corporations and Affiliates as an employee or Associate for any reason with or
without Cause, including, but not by way of limitation, a termination by resignation, discharge, death, or Disability. A Termination
of Service shall not include a termination where the Participant is simultaneously reemployed by, or remains employed by, or
continues to provide services to, the Company and/or one or more of its Related Corporations and Affiliates or a successor entity
thereto.

Section 1.14    Vest or Vested. “Vest” or “Vested” shall mean that, with respect to a share of Performance Stock, both (i)

such share of Performance Stock has Performance-Vested and (ii) the continued service condition has been satisfied.

ARTICLE II.
AWARD OF PERFORMANCE STOCK

Section 2.1    Award of Shares of Performance Stock. Effective as of the Award Date, the Company grants to the
Participant an award of [          ] target shares of Performance Stock (the “Target Performance Shares”). Each share of Performance
Stock represents the Participant’s right to receive one Share under this Award Agreement if the Performance Goals are met during
the Performance Period and the vesting conditions set forth herein are satisfied.

Section 2.2    Forfeiture. Shares of Performance Stock shall be subject to forfeiture as provided in Section 3.2 below.

Section 2.3    Dividend Equivalents. The Participant shall be entitled to receive, with respect to each outstanding Vested
but unissued share of Performance Stock, dividend equivalent amounts equal to the regular quarterly cash dividend paid or made
with respect to the Shares underlying such Vested but unissued shares of Performance Stock (to the extent regular quarterly cash
dividends are paid). Such dividend equivalent amounts shall be aggregated and paid to the Participant within thirty (30) days
following the date on which the Shares underlying the Vested shares of Performance Stock are issued to the Participant, but in no
event later than December 31 of the year in which the Shares underlying the Vested shares of Performance Stock are issued to the
Participant. Notwithstanding the foregoing, if a “Change in Control” occurs prior to the date on which such dividend equivalent
amounts are paid, such dividend equivalent amounts shall be paid to the Participant on the date of the Change in Control; provided,
however, that such payment shall only occur if the Change in Control meets the requirements of Section 409A(a)(2)(A)(v) of the
Internal Revenue Code of 1986, as amended (the “Code”) and its corresponding regulations. For the avoidance of doubt, such
dividend equivalent amounts shall only be paid to the extent that the shares of Performance Stock are Vested as of the applicable
dividend payment date, and the Participant shall not be entitled to receive any dividend equivalent amounts with respect to shares of
Performance Stock that have not Vested as of such dividend payment date. The dividend equivalents and any amounts that may
become payable in respect thereof shall be treated separately from the shares of Performance Stock and the rights

2

arising in connection therewith for purposes of the designation of time and form of payments required by Code Section 409A.

Section 2.4    Voting Rights. The Participant shall not have any voting rights in respect of the shares of Performance Stock

and any Shares underlying the shares of Performance Stock unless and until such Shares shall have been issued by the Company
and the Participant becomes the holder of record of such Shares (as evidenced by the appropriate entry on the books of the
Company or of a duly authorized transfer agent of the Company).

Section 3.1    Vesting.

ARTICLE III.
RESTRICTIONS

(a)    Subject to paragraph (b) below and Sections 3.2 and 3.5 below, shares of Performance Stock shall Vest in cumulative

installments as follows:

(i)    With respect to fiscal year [          ], a number of shares of Performance Stock equal to the product of (x) thirty-

three percent (33%) of the Target Performance Shares, multiplied by (y) the applicable Performance Vesting Percentage
determined in accordance with Exhibit A attached hereto, shall Vest on the first anniversary of the Award Date;

(ii)    With respect to fiscal year [          ], a number of shares of Performance Stock equal to the product of (x) thirty-

three percent (33%) of the Target Performance Shares, multiplied by (y) the applicable Performance Vesting Percentage
determined in accordance with Exhibit A attached hereto, shall Vest on the second anniversary of the Award Date; and

(iii)    With respect to fiscal year [          ], a number of shares of Performance Stock equal to the product of (x) thirty-

four percent (34%) of the Target Performance Shares, multiplied by (y) the applicable Performance Vesting Percentage
determined in accordance with Exhibit A attached hereto, shall Vest on the third anniversary of the Award Date.

(b)    Subject to Sections 3.2 and 3.5 below, in the event that the Company achieves the Catch-Up Performance Goal with

respect to the Performance Period, then any Catch-Up Shares shall Vest on the third anniversary of the Award Date.

Section 3.2    Effect of Termination of Service; Forfeiture.

(a)    In the event the Participant incurs, prior to or on the last day of the Performance Period, a Termination of Service by
reason of the Participant’s Disability or death, any shares of Performance Stock which have not Vested in accordance with Section
3.1 above on or prior to such Termination of Service shall remain outstanding and eligible to Vest in accordance with Section 3.1
above and Section 3.5 below based on the Company’s achievement of the Performance Goals during the Performance Period.

(b)    Immediately upon the Participant’s Termination of Service that is not either (i) a Qualifying Termination within twelve

(12) months following the date of a Change in Control (and prior to or on the last day of the Performance Period) or (ii) a
Termination of Service by reason of the Participant’s Disability or death, the Participant shall automatically and without further
action forfeit all shares of Performance Stock (and all dividend equivalent rights with respect to such shares of Performance Stock)
which have not Vested in accordance with Section

3

3.1 above or Section 3.5 below on or prior to such Termination of Service, and the Participant shall have no further right to or
interest in or with respect to such shares of Performance Stock (or such dividend equivalents).

(c)    Any shares of Performance Stock that do not Performance-Vest in connection with a Change in Control pursuant to

Sections 3.5(a) and 3.5(b) below (and all dividend equivalent rights with respect to such shares of Performance Stock) shall
thereupon automatically be forfeited as of such Change in Control, and the Participant shall have no further right to or interest in or
with respect to such shares of Performance Stock (or such dividend equivalents).

(d)    Any shares of Performance Stock that fail to vest as of the third anniversary of the Award Date (and all dividend
equivalent rights with respect to such Performance Stock) shall automatically and without further action be cancelled and forfeited,
and the Participant shall have no further right to or interest in or with respect to such unvested shares of Performance Stock (or such
dividend equivalents).

Section 3.3    Issuance of Shares.

(a)    Subject to a determination of the Committee as to whether and to what extent the applicable Performance Goals have
been met, Shares represented by shares of Performance Stock which Vest pursuant to Section 3.1 above or Section 3.5 below shall
be issued to the Participant or his or her legal representative on or within five (5) business days following the date on which such
shares of Performance Stock Vest pursuant to Section 3.1 above or Section 3.5 below (but in no event later than December 31 of the
applicable year in which such shares of Performance Stock Vest).

(b)    All Shares issued hereunder shall be issued in certificated form or shall be recorded with the Company’s transfer agent.

All such Shares shall be issued free from any restrictions; provided, however, that such Shares shall be subject to any restrictions
and conditions as may be required pursuant to Section 4.6 below and those that the Company imposes on its employees in general
with respect to selling its Shares. Notwithstanding the foregoing, the Company shall not be required to issue or record such Shares
in the name of the Participant or his or her legal representative unless the Participant or his or her legal representative shall have
satisfied the full amount of all federal, state and local withholding or other employment taxes applicable to the taxable income of
the Participant resulting from the vesting of the shares of Performance Stock and issuance of the Shares as provided in this Award
Agreement (including, without limitation, in the manner set forth in Section 4.3 below).

Section 3.4    Clawback. Notwithstanding anything contained in the Plan or the Award Agreement to the contrary, the

shares of Performance Stock, and any related payments, shall be subject to the provisions of any clawback, repayment or recapture
policy implemented by the Company, including any such policy adopted to comply with applicable law (including without
limitation the Dodd-Frank Wall Street Reform and Consumer Protection Act) or securities exchange listing standards and any rules
or regulations promulgated thereunder, to the extent set forth in such policy and/or in any notice or agreement relating to the shares
of Performance Stock under the Plan.

Section 3.5    Change in Control. In the event that a Change in Control occurs during the Performance Period:

(a)    A number of shares of Performance Stock shall Performance-Vest equal to a number determined at the greater of (i) the

achievement of the “Target Level” Performance Vesting Percentage with respect to the fiscal year in which the Change in Control
occurs, as

4

specified in Exhibit A attached hereto and (ii) the Company’s actual achievement of the Performance Goal for such year through
the Change in Control. Subject to Sections 3.5(d) and (e) below, such Performance-Vested shares of Performance Stock shall
remain outstanding and eligible to Vest on the anniversary of the Award Date immediately following the Change in Control, subject
to the Participant’s continuous service.

(b)    In addition, and subject to Sections 3.5(d) and (e) below, a number of shares of Performance Stock shall Performance-
Vest equal to the number of shares of Performance Stock that could vest with respect to each fiscal year of the Performance Period
following the fiscal year in which the Change in Control occurs (if any) based on the achievement of the “Target Level”
Performance Vesting Percentage with respect to each such year, as specified in Exhibit A, and shall remain outstanding and eligible
to Vest on the date(s) outlined in Section 3.1(a)(ii) and/or (iii) (excluding any Catch-Up Shares which are forfeited in the event of a
Change in Control), subject to the Participant’s continued service.

(c)    In addition, if the Change in Control occurs following the completion of a fiscal year in the Performance Period but

prior to the date on which shares of Performance Stock with respect to such year become Vested pursuant to Section 3.1(a) above,
then such shares of Performance Stock shall Vest as of immediately prior to the Change in Control in a number determined in
accordance with Section 3.1(a) above.

(d)    If the Participant incurred a Termination of Service by reason of the Participant’s Disability or death, in either case,

prior to the Change in Control date, then any shares of Performance Stock that Performance-Vest in accordance with Sections 3.5(a)
and (b) above shall Vest as of immediately prior to the Change in Control.

(e)     Notwithstanding Sections 3.5(a) and 3.5(b) above, if the Participant incurs (1) a Qualifying Termination on or within

twelve (12) months following the date of a Change in Control and prior to or on the last day of the Performance Period, or (2) a
Termination of Service by reason of the Participant’s Disability or death on or following a Change in Control and prior to or on the
last day of the Performance Period, then in either case any Performance-Vested shares of Performance Stock that are then-
outstanding and have not yet Vested shall Vest in full upon such Termination of Service.

ARTICLE IV.
MISCELLANEOUS

Section 4.1    No Additional Rights. Nothing in this Award Agreement or in the Plan shall confer upon any person any
right to a position as an Associate or continued employment by the Company or any of its Related Corporations or Affiliates or
affect in any way the right of any of the foregoing to terminate the services of an individual at any time.

Section 4.2    Anti-Assignment. The Participant shall have no right to sell, assign, transfer, pledge, or otherwise encumber

or dispose of the Participant’s award of shares of Performance Stock.

Section 4.3    Tax Withholding. In satisfaction of all applicable requirements with respect to amounts required by federal,

state or local tax law to be withheld with respect to the vesting, distribution or payment of the shares of Performance Stock, the
Company shall withhold Shares otherwise issuable upon such distribution or payment of the shares of Performance Stock having a
Fair Market Value equal to the sums required to be withheld. Subject to the following sentence, the number of Shares which shall
be so withheld in order to satisfy the Participant’s federal, state and local withholding tax liabilities with respect to the vesting of
the shares of Performance Stock or issuance of Shares in payment of the shares of Performance Stock shall be

5

limited to the number of Shares which have a Fair Market Value on the date of issuance equal to the aggregate amount of such
liabilities based on the minimum statutory withholding rates for federal, state and local tax purposes that are applicable to, and
required in connection with, all or a portion of such supplemental taxable income. In the event that the number of Shares having a
Fair Market Value equal to the sums required to be withheld is not a whole number of Shares, the number of Shares so withheld
shall be rounded up to the nearest whole share.

Section 4.4    Notices. Any notice to be given under the terms of this Award Agreement to the Company shall be addressed

to the Company in care of its Chief Human Resources Officer, and any notice to be given to the Participant shall be addressed to the
Participant at his or her address of record maintained by the Human Resources Department. By a notice given pursuant to this
Section 4.4, either party may hereafter designate a different address for notices to be given to it or him. Any notice which is
required to be given to the Participant shall, if the Participant is then deceased, be given to the Participant’s personal representative
if such representative has previously informed the Company of his or her status and address by written notice under this Section
4.4. Any notice shall have been deemed duly given when enclosed in a properly sealed envelope or wrapper addressed as aforesaid,
deposited (with postage prepaid) in a post office or branch post office regularly maintained by the United States Postal Service.

Section 4.5    Titles. Titles are provided herein for convenience only and are not to serve as a basis for interpretation or

construction of this Award Agreement.

Section 4.6    Conformity to Securities Laws. This Award Agreement is intended to conform to the extent necessary with
all provisions of the Securities Act and the Exchange Act and any and all regulations and rules promulgated by the Securities and
Exchange Commission thereunder, including, without limitation, Rule 16b-3. Notwithstanding anything herein to the contrary, this
Award Agreement shall be administered, and the shares of Performance Stock shall be issued, only in such a manner as to conform
to such laws, rules and regulations. To the extent permitted by applicable law, this Award Agreement and the shares of Performance
Stock issued hereunder shall be deemed amended to the extent necessary to conform to such laws, rules and regulations.

Section 4.7    Amendment. This Award Agreement may be amended only by a writing executed by the parties hereto which

specifically states that it is amending this Award Agreement.

Section 4.8    Governing Law. The laws of the State of Delaware shall govern the interpretation, validity, administration,

enforcement and performance of the terms of this Award Agreement regardless of the law that might be applied under principles of
conflicts of laws.

Section 4.9    Section 409A. This Award Agreement shall be interpreted in accordance with the requirements of Section

409A of the Code. Notwithstanding any provision in this Award Agreement to the contrary, if a payment is deemed to be deferred
compensation subject to the requirements of Section 409A of the Code, such payment may only be made under this Award
Agreement upon an event and in a manner permitted by Section 409A of the Code. If a payment is not made by the designated
payment date under this Award Agreement, the payment shall be made by December 31 of the calendar year in which the
designated date occurs. In no event may the Participant, directly or indirectly, designate the calendar year of payment. A
termination of service shall not be deemed to have occurred for purposes of any provision of this Award Agreement providing for
the payment of any amounts or benefits upon or following a termination of service that are considered “nonqualified deferred
compensation” under Section 409A of the Code unless such termination is also a “separation from service” within the meaning of
Section 409A of the Code and, for purposes of any such provision of this award Agreement, references to a “termination,”
“Termination of Service” or like terms shall mean “separation

6

from service.” Notwithstanding anything to the contrary in this Award Agreement, no amounts payable to the Participant under this
Award Agreement shall be paid to the Participant prior to the expiration of the 6-month period following the Participant’s
“separation from service” if the Company determines that paying such amounts at the time or times indicated in this Award
Agreement would be a prohibited distribution under Section 409A(a)(2)(b)(i) of the Code. If the payment of any such amounts is
delayed as a result of the previous sentence, then on the first day following the end of such 6-month period, the Company shall pay
the Participant a lump-sum amount equal to the cumulative amount that would have otherwise been payable to the Participant
during such 6-month period.

Section 4.10    Electronic Delivery and Acceptance. Participant hereby consents to receive the Notice of Grant of Award
and Award Agreement and any other documents related to this award or future awards by electronic delivery and to accept this or
future awards through an on-line or electronic system established and maintained by the Company or another third party designated
by the Company. Participant acknowledges that he/she has read, understand and agrees to the terms of the Notice of Grant of
Award, Award Agreement and Plan. By clicking the “ACCEPT” button on E*TRADE’s on-line grant agreement response page, it
will act as Participant’s electronic signature to these documents and will result in a contract between Integra LifeSciences Holdings
Corporation and the Participant with respect to the award. In the event of any conflict or inconsistency between the terms and
conditions of this Award Agreement or any other contracts or documents related to this award, on the one hand, and any terms or
conditions set forth in the Plan, the terms and conditions set forth in the Plan shall prevail.

[Signature page follows]

7

    IN WITNESS WHEREOF, the parties hereto have executed this Performance Stock Agreement as of the date first above written.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

THE PARTICIPANT    
Electronic signature to be provided
and recorded via online grant
acceptance process on www.etrade.com

INTEGRA LIFESCIENCES
HOLDINGS CORPORATION

By                    
Name:
Title:

 
 
 
                    
 
                       
 
    
EXHIBIT A

PERFORMANCE GOALS AND PERFORMANCE PERIOD

Capitalized terms shall have the meaning set forth in Performance Stock Agreement.

The “Performance Period” shall be the three-year period beginning [          ] and ending [          ].

The “Catch-Up Performance Goal” shall mean that the Company achieves, as of the end of the Performance Period (but not due to
a Change in Control), an average 3-year Annual Organic Revenue growth rate of at least [          ]%.

With  respect  to  each  fiscal  year  in  the  Performance  Period,  the  “Performance  Goal”  is  that  the  Company  achieves  a  Threshold
Level or higher level of growth in Annual Organic Revenue over the immediately preceding fiscal year, as set forth in the table
below. A number of shares of Performance Stock will Performance-Vest in accordance with Section 3.1 of the Performance Stock
Agreement based on the percentage growth in Annual Organic Revenue over the immediately preceding fiscal year:

“Threshold Level”
“Target Level”
“Maximum Level”

Growth in Annual
Organic Revenue over the
Prior Fiscal Year (%)

Performance Vesting
Percentage

[          ]
[          ]
[          ]
[          ]

[          ]
[          ]
[          ]
[          ]

In the event that the growth in Annual Organic Revenue over the immediately preceding fiscal year falls between the “Threshold
Level”  and  the  “Target  Level,”  then  the  Performance  Vesting  Percentage  shall  be  determined  by  extrapolating  between  the
“Threshold Level,” anchor points of [          ] Annual Organic Revenue growth (with a [          ] Performance Vesting Percentage)
and [          ] Annual Organic Revenue growth (with an [          ] Performance Vesting Percentage), and the “Target Level.” In the
event that the growth in Annual Organic Revenue over the immediately preceding fiscal year falls between the “Target Level” and
the “Maximum Level,” then the Performance Vesting Percentage shall be determined by means of linear interpolation between the
“Target Level,” anchor points of [          ] Annual Organic Revenue growth (with a [          ] Performance Vesting Percentage) and
the “Maximum Level.”

Notwithstanding  the  forgoing,  in  the  event  that  (i)  a  Change  in  Control  does  not  occur  during  the  Performance  Period,  (ii)  the
Performance Goal with respect to a given fiscal year in the Performance Period is not achieved at the applicable Target Level or
higher, and (iii) the Catch-Up Performance Goal is achieved, then a number of shares of Performance Stock equal to the difference
between (x) the number of shares of Performance Stock which would have Vested in the event that the Performance Goal had been
achieved at the Target Level with respect to such

A-<#>

 
 
 
 
 
 
 
fiscal year and (y) the number of shares of Performance Stock which actually became Vested based on the applicable Performance
Vesting  Percentage  for  such  fiscal  year,  shall  become  Vested  in  accordance  with  Section  3.1(b)  of  the  Performance  Stock
Agreement (such number of shares, the “Catch-Up Shares”).

A-1

Exhibit 10.3(k)

    2003 EQUITY INCENTIVE PLAN
    NON-QUALIFIED STOCK OPTION AGREEMENT

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

        NON-QUALIFIED  STOCK  OPTION  AGREEMENT  (together  with  the  attached  Notice  of  Grant  of  Stock  Options  and
Option  Agreement  (“Notice  of  Grant”),  the  “Option  Agreement”)  made  as  of  the  date  (the  “Grant  Date”)  set  forth  in  Notice  of
Grant,  between  Integra  LifeSciences  Holdings  Corporation,  a  Delaware  corporation  (the  “Company”),  and  the  named  Key
Employee of the Company, a Related Corporation, or an affiliate (the “Employee”).

    WHEREAS, the Company desires to afford the Employee an opportunity to purchase shares of common stock of the Company,
par value $.01 per share (“Common Stock”), as hereinafter provided, in accordance with the provisions of the Integra LifeSciences
Holdings Corporation Fifth Amended and Restated 2003 Equity Incentive Plan, as amended (the “Plan”). Requests for hardcopies
of the “Plan” should be directed to Mythili Seshan at the New Jersey Corporate Office.

        NOW,  THEREFORE,  in  consideration  of  the  mutual  covenants  hereinafter  set  forth  and  for  other  good  and  valuable
consideration the legal sufficiency of which is hereby acknowledged, the parties hereto, intending to be legally bound hereby, agree
as follows:

    Capitalized terms not otherwise defined below shall have the meaning set forth in the Plan. The masculine pronoun shall include
the feminine and neuter, and the singular the plural, where the context so indicates.

Grant of Option. Effective [          ], the Company hereby grants to the Employee a non-qualified stock option (the
“Option”) to purchase all or any part of an aggregate of the number of shares of Common Stock as set forth in the attached Notice
of Grant, subject to adjustment in accordance with Section 8 of the Plan.

Purchase Price. The purchase price per share of the shares of Common Stock covered by the Option shall be that set forth

in the attached Notice of Grant, subject to adjustment in accordance with Section 8 of the Plan. It is the determination of the
Company’s Compensation Committee (the “Committee”) that on the Grant Date the per share Option exercise price was not less
than the greater of one hundred percent (100%) of the fair market value of the Common Stock, or the par value thereof.

Term. Unless earlier terminated pursuant to any provision of this Option Agreement, this Option shall expire on [          ]
(the “Expiration Date”). Notwithstanding anything herein to the contrary, this Option shall not be exercisable after the Expiration
Date.

Exercise of Option. Twenty Five percent (25%) of the shares of Stock Options shall become vested each of the first and

second, third and fourth anniversaries of the grant date. Any portion of the Option that becomes exercisable in accordance with the
foregoing shall remain exercisable, subject to the provisions contained in this Option Agreement, until the expiration of the term of
this Option as set forth above or until other termination of the Option as set forth in this Option Agreement.

    
Exhibit 10.3(k)

        Notwithstanding anything contained herein, no portion of the Option which has not become vested and exercisable as of the
Employee’s  termination  of  employment  or  in  connection  with  Employee’s  termination  of  employment  shall  thereafter  become
vested or exercisable.

Method of Exercising Option. Subject to the terms and conditions of this Option Agreement, the Option may be exercised

in whole or in part by written notice to the Company, at its principal office, which currently is located at 1100 Campus Road,
Princeton, New Jersey 08540. Such notice shall state the election to exercise the Option, and the number of shares with respect to
which it is being exercised; shall be signed by the person or persons so exercising the Option; shall, unless the Company otherwise
notifies the Employee, be accompanied by the investment certificate referred to below; and shall be accompanied by payment of the
full Option price of such shares.

        The Option price shall be paid to the Company: (i) in cash; (ii) in cash equivalent; (iii) in Common Stock of the Company, in
accordance with Section 7.1(f)(ii) of the Plan (as in effect on the date of this Option Agreement); (iv) by delivering a properly
executed notice of exercise of the Option, in accordance with Section 7.1(f)(iii) of the Plan (as in effect on the date of this Option
Agreement); (v) in Common Stock of the Company issuable pursuant to the exercise of the Option or otherwise withheld in net
settlement of the Option, in accordance with Section 7.1(f)(iv) of the Plan (as in effect on the date of this Option Agreement); or
(vi) by any combination of (i)-(v).

        Upon receipt of such notice and payment, the Company, as promptly as practicable, shall deliver or cause to be delivered a
certificate or certificates representing the shares with respect to which the Option is so exercised. Such certificate(s) shall be
registered in the name of the person or persons so exercising the Option (or, if the Option is exercised by the Employee and if the
Employee so requests in the notice exercising the Option, shall be registered in the name of the Employee and the Employee’s
spouse, jointly, with right of survivorship) and shall be delivered as provided above to or upon the written order of the person or
persons exercising the Option. In the event the Option is exercised by any person or persons after the legal disability or death of the
Employee, such notice shall be accompanied by appropriate proof of the right of such person or persons to exercise the Option. All
shares that are purchased upon the exercise of the Option as provided herein shall be fully paid and not assessable by the Company.

Shares to be Purchased for Investment. Unless the Company has theretofore notified the Employee that a registration

statement covering the shares to be acquired upon the exercise of the Option has become effective under the Securities Act of 1933
and the Company has not thereafter notified the Employee that such registration statement is no longer effective, it shall be a
condition to any exercise of this Option that the shares acquired upon such exercise be acquired for investment and not with a view
to distribution, and the person effecting such exercise shall submit to the Company a certificate of such investment intent, together
with such other evidence supporting the same as the Company may request. The Company shall be entitled to delay the
transferability of the shares issued upon any such exercise to the extent necessary to avoid a risk of violation of the Securities Act
of 1933 (or of any rules or regulations promulgated thereunder) or of any state laws or regulations. Such restrictions may, at the
option of the Company, be noted or set forth in full on the share certificates.

Non-Transferability of Option. This Option is not assignable or transferable, in whole or in part, by the Employee other

than by will or by the laws of descent and distribution, and during the lifetime of the Employee the Option shall be exercisable only
by the Employee or by his or her guardian or legal representative.

Exhibit 10.3(k)

Termination of Employment. If the Employee’s employment with the Company and all Related Corporations is terminated prior
to the Expiration Date for any reason other than by (i) death or disability or (ii) a Qualifying Termination upon a Change in Control
as further described below, this Option may be exercised, to the extent of the number of shares with respect to which the Employee
could have exercised it on the date of such termination of employment, or to any greater extent permitted by the Committee, by the
Employee at any time prior to the earlier of (i) the Expiration Date or (ii) six (6) months after such termination of employment.

Death. Notwithstanding anything contained in this Option Agreement to the contrary, if the Employee dies during his employment
with the Company and Related Corporations and prior to the Expiration Date, the Option shall become fully vested and exercisable
and such Option upon such death can be exercised by the Employee’s estate, personal representative or beneficiary who acquired
the right to exercise such Option by bequest or inheritance or by reason of the Employee’s death, at any time prior to the earlier of
(i) the Expiration Date or (ii) one year after the date of the Employee’s death.

Disability. Notwithstanding anything contained in this Option Agreement to the contrary, if the Employee incurs a disability, as
defined in the Plan, during his employment with the Company and Related Corporations and, prior to the Expiration Date, the
Employee’s employment is terminated as a consequence of such disability, this Option shall become fully vested and exercisable
and such Option upon such termination due to such Disability can be exercised by the Employee, or in the event of the Employee’s
legal disability, by the Employee’s legal representative, at any time prior to the earlier of (i) the Expiration Date or (ii) one year
after the date of such termination of employment due to such Disability.

Double Trigger Change in Control. Notwithstanding anything contained in this Option Agreement to the contrary, if during the
Employee’s employment with the Company and Related Corporations and prior to the Expiration Date, a Change in Control occurs
and the Employee incurs a Qualifying Termination on or within twelve (12) months following the date of such Change in Control,
this Option shall become fully vested and exercisable and such Option upon such Qualifying Termination can be exercised by the
Employee at any time prior to the Expiration Date.

Clawback Notwithstanding anything contained in the Plan or the Option Agreement to the contrary, the Option shall be subject
to the provisions of any clawback, repayment or recapture policy implemented by the Company, including any such policy
adopted to comply with applicable law (including without limitation the Dodd-Frank Wall Street Reform and Consumer
Protection Act) or securities exchange listing standards and any rules or regulations promulgated thereunder, to the extent set
forth in such policy and/or in any notice or agreement relating to the Option under the Plan.

Withholding of Taxes. The obligation of the Company to deliver shares of Common Stock upon the exercise of the Option

shall be subject to applicable federal, state and local tax withholding requirements. If the exercise of any Option is subject to the
withholding requirements of applicable federal, state or local tax laws, the Committee, in its discretion, may permit the Employee,
subject to the provisions of the Plan and such additional withholding rules (the “Withholding Rules”) as shall be adopted by the
Committee, to satisfy the withholding tax, in whole or in part, by electing to have the Company withhold (or by returning to the
Company) shares of Common Stock, which shares shall be valued, for this purpose, at their fair market value on the date of
exercise of the Option (or, if later, the date on which the Employee recognizes ordinary income

Exhibit 10.3(k)

with respect to such exercise). An election to use shares of Common Stock to satisfy tax withholding requirements must be made in
compliance with and subject to the Withholding Rules. The Committee may not withhold shares in excess of the number necessary
to satisfy the minimum tax withholding requirements.

Construction. This Option Agreement is made under and subject to the provisions of the Plan as in effect on the Grant

Date, and all of the provisions of the Plan as in effect on the Grant Date are hereby incorporated herein as provisions of this Option
Agreement.

Governing Law. This Non-Qualified Stock Option Agreement shall be governed by applicable federal law and otherwise

by the laws of the State of Delaware.

    IN WITNESS WHEREOF, this Option Agreement has been executed and delivered by the parties hereto.

THE PARTICIPANT    
Electronic signature to be provided
and recorded via online grant
acceptance process on www.etrade.com

INTEGRA LIFESCIENCES
HOLDINGS CORPORATION

By                    
Name:
Title:

 
 
 
                
 
    
Exhibit 10.3(l)

RESTRICTED STOCK UNIT AWARD AGREEMENT FOR PARTICIPANTS OUTSIDE THE UNITED STATES

THIS  RESTRICTED  STOCK  UNIT  AWARD  AGREEMENT  including  any  exhibit,  appendix  or  addendum
hereto (the “Award Agreement”), dated as of [          ] (the “Award Date”), is made by and between Integra LifeSciences Holdings
Corporation, a Delaware corporation (the “Company”), and [          ] hereinafter referred to as the “Participant,” a Key Employee
or Associate (as defined in the Plan).

WHEREAS,  the  Company  has  established  and  maintains  the  Integra  LifeSciences  Holdings  Corporation  Fifth

Amended and Restated 2003 Equity Incentive Plan, as amended from time to time (the “Plan”);

WHEREAS the Company has determined that it would be to the advantage and best interest of the Company and its
shareholders  to  grant  an  award  of  Restricted  Stock  Units  (“RSUs”)  provided  for  herein  to  the  Participant  as  an  incentive  for
increased efforts during the Participant’s employment with or services for the Company or its Related Corporations or Affiliates;

WHEREAS,  Restricted  Stock  Units  can  be  granted,  and  the  shares  of  common  stock  of  the  Company  (the

“Shares”) subject to the RSUs can be issued, under Section 7.8 of the Plan; and

NOW,  THEREFORE,  in  consideration  of  the  various  covenants  herein  contained,  and  intending  to  be  legally

bound hereby, the parties hereto agree as follows:

ARTICLE I.
DEFINITIONS

Capitalized terms not otherwise defined below shall have the meaning set forth in the Plan. The masculine pronoun

shall include the feminine and neuter, and the singular the plural, where the context so indicates.

Section 1.1    “Award Date” shall have the meaning set forth in the recitals.

Section  1.2        “Cause”  shall  mean,  with  respect  to  any  Participant,  “Cause”  as  defined  in  such  Participant’s
employment agreement or severance agreement with the Company if such an agreement exists and contains a definition of Cause
or, if no such agreement exists or such agreement does not contain a definition of Cause, then Cause shall mean (i) the Participant’s
neglect of duties or responsibilities that he or she is required to perform for the Company or any willful failure by the Participant to
obey a lawful direction of the Board or the Company; (ii) the Participant’s engaging in any act of dishonesty, fraud, embezzlement,
misrepresentation or other act of moral turpitude; (iii) the Participant’s knowing violation of any federal or state law or regulation
applicable  to  the  Company’s  business;  (iv)  the  Participant’s  material  breach  of  any  confidentiality,  non-compete  agreement  or
invention assignment agreement or any other material agreement between the Participant and the Company; (v) the Participant’s
conviction  of,  or  plea  of  nolo  contendere  to,  any  felony  or  crime  of  moral  turpitude  which  conviction  or  plea  is  materially  and
demonstrably  injurious  to  the  Company  or  any  of  its  subsidiaries;  (vi)  failure  by  the  Participant  to  comply  with  the  Company’s
material written policies or rules; or (vii) the Participant’s act or omission in the course of his or her employment which constitutes
gross negligence or willful misconduct.

 
Exhibit 10.3(l)

Section 1.3    “Plan” shall have the meaning set forth in the recitals.

Section 1.4    “Restricted Stock Units” or “RSUs” shall mean a conditional right to receive Shares pursuant to the terms of
the Plan and this Award Agreement upon vesting and settlement, subject to the Participant’s continued employment through each
vesting date set forth in the Notice of Grant of Award, unless otherwise set forth in this Award Agreement.

Section 1.5    “Rule 16b-3” shall mean that certain Rule 16b-3 under the U.S. Exchange Act, as such Rule may be amended

from time to time.

Section 1.6    “Secretary” shall mean the Secretary of the Company.

Section 1.7    “Service Recipient” shall mean the Company, Related Corporation or Affiliate with which the Participant has

an employment or service relationship.

Section  1.8        “Termination  Date”  shall  mean  the  date  the  Participant  is  no  longer  actively  providing  services  to  the
Company, a Related  Corporation  or  Affiliate  (regardless  of  the  reason  for  such termination and whether or not later found to be
invalid or in breach of applicable laws in the jurisdiction where the Participant is employed or rendering services or the terms of the
Participant’s employment or service agreement, if any) and, unless otherwise expressly provided for in this Award Agreement or
determined by the Company, will not be extended by any notice period (e.g., the Participant’s period of employment or service will
not include any contractual notice period or any period of “garden leave” or similar period mandated under applicable laws in the
jurisdiction where the Participant is rendering services or the terms of the Participant’s employment or service agreement, if any).
The Committee shall have the exclusive discretion to determine when the Participant’s service is terminated for purposes of this
Award of RSUs (including when the Participant is no longer considered to be providing service while on a leave of absence).

ARTICLE II.
GRANT OF RESTRICTED STOCK UNITS AND ISSUANCE OF SHARES

Section 2.1    Grant of RSUs. The Company hereby grants [              ]  RSUs  to  the  Participant  as  of  the  Award  Date,  in
accordance with and subject to the terms, conditions and restrictions of this Award Agreement and the Plan. RSUs shall be credited
to an account maintained for the Participant on the books of the Company, as of the Award Date.

Section 2.2    Vesting  of  RSUs.  Subject  to  the  terms  and  conditions  of  this  Award  Agreement  and  the  Plan,  33%  of  the
RSUs awarded hereunder shall vest on each of the first and second anniversary of the Award Date and 34% will vest on the third
anniversary of the Award Date (each a “Vesting Date”) provided the Participant remains a Key Employee or Associate from the
Award Date until the Vesting Date.

Section  2.3        Termination  of  Service  (other  than  by  (i)  Death  or  Disability  or  (ii)  a  Qualifying  Termination  on  or
Following a Change in Control). Upon the Participant’s termination of service prior to the Vesting Date, other than by (i) death or
Disability or (ii) a Qualifying Termination on or within twelve months following the date of a Change in Control and, except as
otherwise determined by the Compensation Committee of the Company (the “Committee”), any RSUs granted to the Participant
under this Award Agreement which have not yet vested on the Termination Date shall terminate without payment and shall be of no
further force or effect from and after the Termination Date.

Section 2.4    Death or Disability. If a Participant dies or suffers a Disability prior to the Vesting Date, all RSUs held by the

Participant immediately prior to death or Disability,

Exhibit 10.3(l)

which have not yet vested at the time of death or Disability, shall become fully vested and all forfeiture restrictions thereon shall
lapse upon such death or Disability.

Section  2.5        Change in Control. In  the  event  that  a  Change  in  Control  occurs  and  the  Participant  incurs  a  Qualifying
Termination on or within twelve (12) months following the date of such Change in Control, the RSUs shall become fully vested and
all forfeiture restrictions shall lapse upon such Qualifying Termination.

Section 2.6    Acceleration of Vesting. Notwithstanding  the  provisions  of  Sections  2.2,  2.3,  2.4,  and  2.5,  the  Committee
may, in its sole discretion, at any time prior to or following the events contemplated in such Sections, permit the vesting of any or
all RSUs held by the Participant and the issuance of Shares in respect of such RSUs in the manner and on the terms authorized by
the  Committee,  provided  that  the  Committee  will  not,  in  any  case,  authorize  the  vesting  of  an  RSU  or  the  issuance  of  a  Share
pursuant to this Section beyond the Vesting Date. If so accelerated, such RSUs will be considered as having vested as of the date
specified by the Committee. If the Participant is a U.S. taxpayer, the payment of Shares upon vesting pursuant to this Section 2.6
shall in all cases be paid at a time or in a manner that is exempt from, or complies with, Section 409A. The prior sentence may be
superseded in a future agreement or amendment to this Award Agreement only by direct and specific reference to such sentence.
Notwithstanding anything in the Plan or this Award Agreement or any other agreement (whether entered into before, on or after the
Award Date), if the vesting of the balance, or some lesser portion of the balance, of the RSUs is accelerated in connection with the
Participant’s termination of service (provided that such termination is a “separation from service” within the meaning of Section
409A, as determined by the Company), other than due to the Participant’s death, and if (x) the Participant is a U.S. taxpayer and a
“specified employee” within the meaning of Section 409A at the time of such termination of service and (y) the payment of such
accelerated RSUs will result in the imposition of additional tax under Section 409A if paid to the Participant on or within the six (6)
month period following the Participant’s termination of service, then the payment of such accelerated RSUs will not be made until
the  date  six  (6)  months  and  one  (1)  day  following  the  date  of  Participant’s  termination  of  service,  unless  the  Participant  dies
following his or her termination of service, in which case, the RSUs will be paid in Shares to the Participant’s estate as soon as
practicable following his or her death.

Section  2.7        Settlement.  On  or  as  soon  as  administratively  practicable  (and  any  event  within  30  days)  following  each
Vesting Date, the Company shall cause to be issued to the Participant Shares with respect to the RSUs that become vested on such
Vesting Date.

Section 2.8    Fractions. No fractional Share will be issued pursuant to an award granted hereunder. The number of Shares
issuable to the Participant upon payment of any award granted under this Award Agreement will be rounded down to the nearest
whole number of Share. No payment or other adjustment will be made with respect to the fractional Share so disregarded.

Section 2.9    Section 409A. It is the intent of this Award Agreement that it and all payments and benefits to U.S. taxpayers
hereunder be exempt from, or comply with, the requirements of Section 409A so that none of the RSUs provided under this Award
Agreement or Shares issuable thereunder will be subject to the additional tax imposed under Section 409A, and any ambiguities
herein  will  be  interpreted  to  be  so  exempt  or  so  comply.  Each  payment  payable  under  this  Award  Agreement  is  intended  to
constitute a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). However, in no event will the Company
reimburse the Participant, or be otherwise responsible for, any taxes or costs that may be imposed on the Participant as a result of
Section 409A.

Exhibit 10.3(l)

Section  2.10        Adjustments  to  Restricted  Stock  Units.  In  the  event  of  any  subdivision,  consolidation,  stock  dividend,
capital  reorganization,  reclassification,  exchange,  or  other  change  with  respect  to  the  Shares,  or  a  consolidation,  amalgamation,
merger,  spin-off,  sale,  lease  or  exchange  of  all  or  substantially  all  of  the  property  of  the  Company  or  other  distribution  of  the
Company's assets to stockholders (other than the payment of ordinary cash dividends), the account of the Participant and the RSUs
held  by  the  Participant  shall  be  adjusted  in  such  manner,  if  any,  as  the  Committee  may  in  its  discretion  deem  appropriate  to
preserve, proportionally, the interests of the Participant under the Plan.

Section  2.11        Forfeiture/Clawback.  Notwithstanding  anything  contained  in  the  Plan  or  the  Award  Agreement  to  the
contrary, the RSUs shall be subject to the provisions of any clawback, repayment or recapture policy implemented by the Company,
including any such policy adopted to comply with applicable law (including without limitation the Dodd-Frank Wall Street Reform
and Consumer Protection Act) or securities exchange listing standards and any rules or regulations promulgated thereunder, to the
extent set forth in such policy and/or in any notice or agreement relating to the RSUs under the Plan.

ARTICLE III.
ADDITIONAL TERMS AND CONDITIONS

Section  3.1        Status  of  Plan.  The  terms  of  the  Plan  are  incorporated  by  reference  into,  and  made  part  of,  this  Award

Agreement. In the event of a conflict between the Plan and this Award Agreement, the terms of the Plan shall govern.

Section 3.2    Committee’s Authority. The Committee shall have the power to interpret the Plan and this Award Agreement
and to adopt such rules for the administration, interpretation and application of the Plan as are consistent therewith and to interpret
or  revoke  any  such  rules  (including,  but  not  limited  to,  the  determination  of  whether  or  not  any  RSUs  have  vested).  All  actions
taken  and  all  interpretations  and  determinations  made  by  the  Committee  in  good  faith  shall  be  final  and  binding  upon  the
Participant,  the  Company  and  all  other  interested  persons.  The  Committee  shall  not  be  personally  liable  for  any  action,
determination or interpretation made in good faith with respect to the Plan or this Award Agreement. The Committee shall, in its
absolute discretion, determine when such conditions have been fulfilled.

Section 3.3    Nature of Grant. By accepting the grant of the RSUs, the Participant acknowledges, understands and agrees

that:

(i)    the Plan is established voluntarily by the Company, is discretionary in nature and may be modified, amended,

suspended or terminated by the Company at any time to the extent permitted in the Plan;

(ii)    the grant of the RSUs is exceptional voluntary and occasional and does not create any contractual or other right

to receive future grants of RSUs or benefits in lieu of RSUs, even if RSUs have been awarded in the past;

(iii)    all decisions with respect to future grants of RSUs, if any, will be at the sole discretion of the Company;

(iv)    the Participant is voluntarily participating in the Plan;

(v)    the grant of the RSUs and any Shares subject to the RSUs, and the income from and value of same, are not

intended to replace any pension rights or compensation;

Exhibit 10.3(l)

(vi)    unless otherwise agreed with the Company in writing, the RSUs and the Shares subject to the RSUs, and the
income from and value of same, are not granted as consideration for, or in connection with, any service the Participant may provide
as a director of a Related Corporation or an Affiliate;

(vii)    the award of the RSUs and the Shares subject to the RSUs, and the income from and value of same are not
part  of  normal  or  expected  compensation  or  salary  for  any  purposes,  including,  but  not  limited  to,  calculating  any  severance,
resignation, termination, redundancy, end of service payments, bonuses, holiday pay, long-service awards, pension or retirement or
welfare  benefits  or  similar  payments  and  in  no  event  should  be  considered  as  compensation  for,  or  relating  in  any  way  to,  past
services for the Company or any Related Corporation or Affiliate;

(viii)    the future value of the Shares underlying the RSUs is unknown, indeterminable and cannot be predicted with

certainty;

(ix)    no claim or entitlement to compensation or damages shall arise from forfeiture of the RSUs resulting from the
Participant’s termination of employment, or other service relationship (for any reason whatsoever and whether or not later found to
be invalid or in breach of employment laws in the jurisdiction where the Participant is employed or the terms of the Participant’s
employment agreement, if any);

(x)    neither the Company, the Service Recipient nor any other Related Corporation or Affiliate shall be liable for
any exchange rate fluctuation between the Participant’s local currency and the U.S. Dollar that may affect the value of the RSUs or
of  any  amounts  due  to  the  Participant  pursuant  to  the  vesting  and  settlement  of  the  RSUs  or  the  subsequent  sale  of  any  Shares
acquired upon settlement; and

(xi)        the  Company  is  not  providing  any  tax,  legal  or  financial  advice,  nor  is  the  Company  making  any
recommendations regarding the Participant’s participation in the Plan or sale of the Shares acquired upon vesting and settlement of
the  RSUs.  The  Participant  should  consult  with  his  or  her  own  personal  tax,  legal  and  financial  advisors  regarding  his  or  her
participation in the Plan before taking any action related to the Plan.

Section 3.4    Responsibility for Taxes. The Participant acknowledges that, regardless of any action taken by the Company
or,  if  different,  the  Service  Recipient,  the  ultimate  liability  for  all  income  tax,  social  insurance,  payroll  tax,  fringe  benefits  tax,
payment on account, and other tax-related items related to the Participant’s participation in the Plan and legally applicable to the
Participant  or  deemed  applicable  to  the  Participant  (“Tax-Related  Items”)  is  and  remains  Participant’s  responsibility  and  may
exceed the amount, if any, actually withheld by the Company or the Service Recipient. The Participant further acknowledges that
the Company and/or the Service Recipient (i) make no representations or undertakings regarding the treatment of any Tax-Related
Items  in  connection  with  any  aspect  of  the  RSUs  or  the  underlying  Shares,  including,  but  not  limited  to,  the  grant,  vesting  or
settlement of the RSUs, the subsequent sale of Shares acquired pursuant to such settlement and the receipt of any dividends or other
distributions paid on the Shares, and (ii) do not commit to and are under no obligation to structure the terms of the grant or any
aspect  of  the  RSUs  to  reduce  or  eliminate  the  Participant’s  liability  for  Tax-Related  Items  or  achieve  any  particular  tax  result.
Further,  if  the  Participant  is  subject  to  Tax-Related  Items  in  more  than  one  jurisdiction,  the  Participant  acknowledges  that  the
Company and/or the Service Recipient (or former service recipient, as applicable) may be required to withhold or account for Tax-
Related Items in more than one jurisdiction.

(i)    Tax Withholding. Prior to any relevant taxable or tax withholding event, as applicable, the Participant agrees to

make arrangements satisfactory to the Company and the

Exhibit 10.3(l)

Service  Recipient  to  satisfy  any  applicable  withholding  obligations  the  Company  or  the  Service  Recipient  may  have  for  Tax-
Related Items. In this regard, the Participant authorizes the Company and the Service Recipient, as applicable, and their respective
agents, at their discretion, to satisfy any applicable withholding obligation for Tax-Related Items by one or a combination of the
following:

Service Recipient;

(a)    withholding from wages or other cash compensation payable to the Participant by the Company or any

Company or the Service Recipient;

(b)        requiring  the  Participant  to  tender  a  cash  payment  or  make  a  payment  in  a  form  acceptable  to  the

(c)    withholding from proceeds of the sale of Shares to be issued upon vesting of the RSUs either through a
voluntary  sale  or  through  a  mandatory  sale  arranged  by  the  Company  (on  the  Participant’s  behalf  pursuant  to  this  authorization
without further consent);

(d)        withholding  in  Shares  to  be  issued  upon  vesting  of  the  RSUs  (in  which  case  the  Participant  will  be
deemed to have been issued the full number of Shares subject to the vested portion of the RSUs, notwithstanding that a number of
the Shares are held back solely for the purpose of paying the Tax-Related Items); and

laws, approved by the Committee.

(e)    any other method acceptable to the Company and to the extent required under the Plan and applicable

The  Company  and/or  the  Service  Recipient  may  withhold  or  account  for  Tax-Related  Items  by  considering  statutory
withholding  rates  or  other  applicable  withholding  rates,  including  minimum  or  maximum  rates  applicable  in  the  Participant’s
jurisdiction(s).  In  the  event  of  over-withholding  or  if  the  maximum  applicable  rate  for  the  Participant’s  jurisdiction  is  used  in
connection with the withholding methods described in (c) or (d) above, the Participant may receive a refund of any over-withheld
amount in cash (with no entitlement to the equivalent amount in Shares), or if not refunded, the Participant may be able to seek a
refund from the applicable tax authorities. In the event of under-withholding, the Participant may be required to pay additional Tax-
Related  Items  directly  to  the  applicable  tax  authorities  or  to  the  Company  and/or  the  Service  Recipient.  If  any  applicable
withholding obligation for Tax-Related Items is satisfied by withholding in Shares, for tax purposes, the Participant will be deemed
to have been issued the full number of Shares subject to the vested RSUs, notwithstanding that a number of the Shares is held back
solely for the purpose of paying the Tax-Related Items. The Participant agrees to pay to the Company or the Service Recipient any
amount of Tax-Related Items that the Company or the Service Recipient may be required to withhold or account for as a result of
the Participant’s participation in the Plan that cannot be satisfied by the means previously described. The Company may refuse to
deliver the Shares or the proceeds of the sale of Shares, if the Participant fails to comply with the Participant’s obligations for Tax-
Related Items.

(ii)        Tax  Consequences.  The  Participant  has  reviewed  with  his  or  her  own  tax  advisors  the  applicable  tax
consequences  of  this  investment  and  the  transactions  contemplated  by  this  Award  Agreement.  With  respect  to  such  matters,  the
Participant relies solely on such advisors and not on any statements or representations of the Company or any of its agents, written
or oral.

Section 3.5    Restricted Stock Units Non-Transferable. Except to the limited extent provided in Section 2, this Award and
the  rights  and  privileges  conferred  hereby  will  not  be  transferred,  assigned,  pledged  or  hypothecated  in  any  way  (whether  by
operation of law or otherwise) and will not be subject to sale under execution, attachment or similar process. Upon any attempt to
transfer, assign, pledge, hypothecate or otherwise dispose of this Award, or any

Exhibit 10.3(l)

right or privilege conferred hereby, or upon any attempted sale under any execution, attachment or similar process, this Award and
the rights and privileges conferred hereby immediately will become null and void.

Section 3.6    Unfunded and Unsecured Plan. The Participant acknowledges that the Plan is unfunded and the Company’s
obligations under the Plan and this Award Agreement are unsecured and that, to the extent the Participant or his or her estate holds
any rights by virtue of a grant of RSUs, such rights shall be no greater than the rights of an unsecured creditor of the Company.

Section 3.7    No Stockholder Rights. Under no circumstances shall RSUs be considered Shares or other securities of the
Company,  nor  shall  they  entitle  the  Participant  to  exercise  voting  rights,  to  receive  dividends  or  other  distributions  or  credit
therefor, or to exercise or receive any other rights attaching to the ownership of Shares or other securities of the Company, nor shall
the Participant be considered the owner of Shares by virtue of the award of RSUs.

Section 3.8    No Guarantee of Continued Employment. THE  PARTICIPANT  ACKNOWLEDGES  AND  AGREES
THAT THE VESTING OF THE RESTRICTED STOCK UNITS PURSUANT TO THE VESTING SCHEDULE HEREOF
IS  EARNED  ONLY  BY  CONTINUING  AS  AN  EMPLOYEE  OR  SERVICE  PROVIDER  AT  THE  WILL  OF  THE
COMPANY (OR, IF DIFFERENT, THE SERVICE RECIPIENT) AND NOT THROUGH THE ACT OF BEING HIRED,
BEING  GRANTED  THIS  AWARD  OF  RESTRICTED  STOCK  UNITS  OR,  AS  APPLICABLE,  ACQUIRING  SHARES
HEREUNDER. THE PARTICIPANT FURTHER ACKNOWLEDGES AND AGREES THAT THIS AGREEMENT, THE
TRANSACTIONS CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH IN THE NOTICE
OF  GRANT  OF  AWARD  DO  NOT  CONSTITUTE  AN  EXPRESS  OR  IMPLIED  PROMISE  OF  CONTINUED
ENGAGEMENT  AS  AN  EMPLOYEE  OR  SERVICE  PROVIDER  FOR  THE  VESTING  PERIOD,  FOR  ANY  PERIOD,
OR AT ALL, AND SHALL NOT INTERFERE IN ANY WAY WITH THE PARTICIPANT’S RIGHT OR THE RIGHT OF
THE  COMPANY  (OR  SUBSIDIARY  EMPLOYING  THE  PARTICIPANT)  TO  TERMINATE  THE  PARTICIPANT’S
EMPLOYMENT OR SERVICE RELATIONSHIP AT ANY TIME, WITH OR WITHOUT CAUSE.

Section 3.9    Notices. Any notice to be given under the terms of this Award Agreement to the Company shall be addressed
to the Company in care of its Secretary, and any notice to be given to the Participant shall be addressed to him at the address given
beneath his signature hereto. By a notice given pursuant to this Section 3.9, either party may hereafter designate a different address
for  notices  to  be  given  to  it  or  him.  Any  notice  which  is  required  to  be  given  to  the  Participant  shall,  if  the  Participant  is  then
deceased, be given to the Participant’s personal representative if such representative has previously informed the Company of his
status  and  address  by  written  notice  under  this  Section  3.9.  Any  notice  shall  have  been  deemed  duly  given  when  enclosed  in  a
properly sealed envelope or wrapper addressed as aforesaid, deposited (with postage prepaid) in a post office or branch post office
regularly maintained by the U.S. Postal Service or comparable foreign postal service.

Section 3.10    Compliance with Laws. Notwithstanding any other provision of the Plan or this Award Agreement, unless
there  is  an  available  exemption  from  any  registration,  qualification  or  other  legal  requirement  applicable  to  the  Shares,  the
Company  shall  not  be  required  to  permit  the  issuance  and/or  deliver  any  Shares  prior  to  the  completion  of  any  registration  or
qualification of the Shares under any U.S. or non-U.S. local, state or federal securities or exchange control law or under rulings or
regulations of the U.S. Securities and Exchange Commission (“SEC”) or of any other governmental regulatory body, or prior to

Exhibit 10.3(l)

obtaining  any  approval  or  other  clearance  from  any  U.S.  or  non-U.S.  local,  state  or  federal  governmental  agency,  which
registration, qualification or approval the Company shall, in its absolute discretion, deem necessary or advisable. The  Participant
understands  that  the  Company  is  under  no  obligation  to  register  or  qualify  the  Shares  with  the  SEC  or  any  state  or  non-U.S.
securities  commission  or  to  seek  approval  or  clearance  from  any  governmental  authority  for  the  issuance  or  sale  of  the  Shares
subject  to  the  RSUs.  Further,  the  Participant  agrees  that  the  Company  shall  have  unilateral  authority  to  amend  this  Award
Agreement without the Participant’s consent to the extent necessary to comply with securities or other laws applicable to issuance
of the Shares subject to the RSUs.

Section 3.11    Modifications to the Award Agreement. Modifications to this Award Agreement or the Plan can be made
only in an express written contract executed by a duly authorized officer of the Company. Notwithstanding anything to the contrary
in  the  Plan  or  this  Award  Agreement,  the  Company  reserves  the  right  to  revise  this  Award  Agreement  as  it  deems  necessary  or
advisable, in its sole discretion and without the consent of the Participant, to comply with Section 409A of the Code or to otherwise
avoid imposition of any additional tax or income recognition under Section 409A of the Code prior to the actual issuance of Shares
pursuant to this award of RSUs.

Section 3.12    Amendment, Suspension or Termination of the Plan. By accepting this Award Agreement or RSUs, the
Participant expressly warrants that he or she has received an award of RSUs under the Plan, and has received, read and understood
a description of the Plan. The Participant understands that the Plan is discretionary in nature and may be amended, suspended or
terminated by the Company at any time.

Section  3.13        Governing  Law  and  Venue.  The  laws  of  the  State  of  Delaware  shall  govern  the  interpretation,  validity,
administration,  enforcement  and  performance  of  the  terms  of  this  Award  Agreement  regardless  of  the  law  that  might  be  applied
under principles of conflicts of laws. For purposes of litigating any dispute that arises under this grant or this Award Agreement, the
parties hereby submit to and consent to the jurisdiction of the State of New Jersey and agree that such litigation shall be conducted
in the state and/or federal courts located in New Jersey, where this grant is made and/or to be performed.

Section 3.14    Assignment. Rights and obligations of the Company under this Award Agreement may be assigned by the
Company  to  a  successor  in  the  business  of  the  Company,  any  company  resulting  from  any  amalgamation,  reorganization,
combination, merger or arrangement of the Company, or any company acquiring all or substantially all of the assets or business of
the Company.

Section 3.15    Consent to the Collection, Processing, Use and Transfer of the Participant’s Personal Data.

(a) General. The Company is located at 1100 Campus Road, Princeton New Jersey, 08540, United States of America and
grants  awards  under  the  Plan  to  employees  of  the  Company  and  Related  Corporations  or  Affiliates  in  its  sole  discretion.  In
conjunction with the Company’s grant of the RSUs under the Plan to the Participant and its ongoing administration of such
awards,  the  Company  is  providing  the  following  information  about  its  data  collection,  processing  and  transfer  practices
(“Personal  Data  Activities”).  In  accepting  the  grant  of  the  RSUs,  the  Participant  expressly  and  explicitly  consents  to  the
Personal Data Activities as described herein.

(b) Data Collection, Processing and Usage. The Company collects, processes and uses the Participant’s personal data,
including the Participant’s name, home address, email address, and telephone number, date of birth, social insurance number
or other identification

Exhibit 10.3(l)

number,  salary,  citizenship,  job  title,  any  Shares  or  directorships  held  in  the  Company,  and  details  of  all  RSUs  or  any  other
equity compensation awards granted, canceled, exercised, vested, or outstanding in the Participant’s favor, which the Company
receives  from  the  Participant  or  the  Service  Recipient.  In  granting  the  RSUs  under  the  Plan,  the  Company  will  collect  the
Participant’s  personal  data  for  purposes  of  allocating  Shares  and  implementing,  administering  and  managing  the  Plan.  The
Company’s legal basis for the collection, processing and usage of the Participant’s personal data is the Participant’s consent.

(c) Stock  Plan  Administration  Service  Provider.  The  Company  transfers  the  Participant’s  personal  data  to  E*TRADE
Securities LLC and its affiliated companies (“E*TRADE”), American Stock Transfer & Trust Company, LLC and its affiliated
companies  (“AST”),  independent  service  providers  based  in  the  United  States,  which  assist  the  Company  with  the
implementation,  administration  and  management  of  the  Plan  (together,  the  “Stock  Plan  Administrator”).  In  the  future,  the
Company may select a different Stock Plan Administrator and share the Participant’s personal data with another company that
serves in a similar manner. The Stock Plan Administrator will open an account for the Participant to receive and trade Shares
acquired under the Plan. The Participant will be asked to agree on separate terms and data processing practices with the Stock
Plan Administrator, which is a condition to the Participant’s ability to participate in the Plan.

(d) International Data Transfers. The Company and the Stock Plan Administrator are based in the United States. The
Participant should note that the Participant’s country of residence may have enacted data privacy laws that are different from
the  United  States.  The  Company’s  legal  basis  for  the  transfer  of  the  Participant’s  personal  data  to  the  United  States  is  the
Participant’s consent.

(e) Voluntariness and Consequences of Consent Denial or Withdrawal. The Participant’s participation in the Plan and
his or her grant of consent is purely voluntary. The  Participant  may  deny  or  withdraw  his  or  her  consent  at  any  time.  If  the
Participant  does  not  consent,  or  if  the  Participant  later  withdraws  his  or  her  consent,  the  Participant  may  be  unable  to
participate in the Plan. This would not affect the Participant’s existing employment or salary; instead, the Participant merely
may forfeit the opportunities associated with the Plan.    

(f) Data Subjects Rights. The Participant may have a number of rights under the data privacy laws in the Participant’s
country of residence. For example, the Participant’s rights may include the right to (i) request access or copies of personal data
the  Company  processes,  (ii)  request  rectification  of  incorrect  data,  (iii)  request  deletion  of  data,  (iv)  place  restrictions  on
processing, (v) lodge complaints with competent authorities in the Participant’s country of residence, and/or (vi) request a list
with the names and addresses of any potential recipients of the Participant’s personal data. To receive clarification regarding
the  Participant’s  rights  or  to  exercise  his  or  her  rights,  the  Participant  should  contact  his  or  her  local  human  resources
department.

Section 3.16    Electronic Delivery and Acceptance. The Participant hereby consents to receive the Notice of Grant of
Award and Award Agreement and any other documents related to this award or future awards by electronic delivery and to
accept  this  or  future  awards  through  an  on-line  or  electronic  system  established  and  maintained  by  the  Company  or
another  third-party  designated  by  the  Company.  The  Participant  acknowledges  that  he/she  has  read,  understands  and
agrees to the terms of the Notice of Grant of Award and Award Agreement. Further, if the Participant does not decline the
Award by written notice to the Company no later than 60 days following the date of grant or such other date that may be
communicated by the Company, the Company will automatically accept the Award, subject to all terms and conditions set
forth in the Notice

Exhibit 10.3(l)

of Grant of Award and Award Agreement and the Plan, on the Participant’s behalf. If the Participant properly declines the
Award,  the  Award  will  be  cancelled  and  the  Participant  will  not  be  entitled  to  any  benefits  from  the  Award  nor  any
compensation or benefits in lieu of the cancelled Award.

Section 3.17    Waivers. No waiver by either party of any breach of, or of compliance with, any condition or provision of
this Award Agreement by the other party shall be considered a waiver of any other condition or provision or of the same condition
or provision at another time.

Section 3.18    Exhibit. Notwithstanding any provisions in this Award Agreement, this Award of RSUs shall be subject to
any special terms and conditions for the Participant’s country set forth in Exhibit A attached hereto. Moreover, if the Participant
relocates  to  one  of  the  countries  included  in  Exhibit  A,  the  special  terms  and  conditions  for  such  country  will  apply  to  the
Participant, to the extent the Company determines that the application of such terms and conditions is necessary or advisable for
legal or administrative reasons. Exhibit A constitutes part of this Award Agreement.

Section 3.19    Entire Agreement. The Notice of Grant of Award, this Award Agreement and the Plan constitute the entire
contract between the parties hereto with regard to the subject matter hereof. They supersede any other agreements, representations
or  understandings  (whether  oral  or  written  and  whether  express  or  implied)  which  relate  to  the  subject  matter  hereof.  The
Participant expressly warrants that he or she is not accepting this Award Agreement in reliance on any promises, representations, or
inducements other than those contained herein.

Section 3.20    Severability. The provisions of this Award Agreement are severable and if any one or more provisions are
determined to be illegal or otherwise unenforceable, in whole or in part, the remaining provisions shall nevertheless be binding and
enforceable.

Section 3.21    Language. If the Participant has received this Award Agreement, or any other document related to the Plan
translated into a language other than English and if the meaning of the translated version is different than the English version, the
English version will control.

Section  3.22        Foreign  Asset/Account  Reporting  Requirements,  Exchange  Controls  and  Tax  Requirements.  The
Participant  acknowledges  that  his  or  her  country  may  have  certain  foreign  asset  and/or  account  reporting  requirements  and
exchange controls which may affect his or her ability to acquire or hold Shares under the Plan or cash received from participating in
the Plan (including from any dividends or sale proceeds arising from the sale of Shares) in a brokerage or bank account outside his
or her country. The Participant understands that he or she may be required to report such accounts, assets or transactions to the tax
or other authorities in his or her country. The Participant also may be required to repatriate sale proceeds or other funds received as
a  result  of  the  Participant’s  participation  in  the  Plan  to  his  or  her  country  through  a  designated  bank  or  broker  and/or  within  a
certain time after receipt. In addition, the Participant may be subject to tax payment and/or reporting obligations in connection with
any income realized under the Plan and/or from the sale of Shares. The Participant acknowledges that it is his or her responsibility
to be compliant with all such requirements, and that the Participant should consult his or her personal legal and tax advisors, as
applicable, to ensure the Participant’s compliance.

Section  3.23        Insider  Trading  and  Market-abuse  Laws.  The  Participant  acknowledges  that,  depending  on  the
Participant’s or his or her broker’s country of residence or where the Shares are listed, the Participant may be subject to insider-
trading restrictions and/or

Exhibit 10.3(l)

market-abuse laws, which may affect the Participant’s ability to accept, acquire, sell or otherwise dispose of Shares, rights to Shares
(e.g.,  the  RSUs),  or  rights  linked  to  the  value  of  Shares  (e.g.,  phantom  awards,  futures)  during  such  times  as  the  Participant  is
considered  to  have  “inside  information”  regarding  the  Company  (as  defined  by  law  or  regulations  in  the  Participant’s  country).
Local insider trading laws and regulations may prohibit the cancellation or amendment of orders the Participant placed before the
Participant possessed inside information. Furthermore, the Participant could be prohibited from (i) disclosing the inside information
to any third party (other than on a “need to know” basis) and (ii) “tipping” third parties, including fellow employees, or causing
them otherwise to buy or sell securities. Any restrictions under these laws or regulations are separate from and in addition to any
restrictions that may be imposed under the Company’s insider-trading policy. The Participant understands that it is the Participant’s
responsibility to comply with any applicable restrictions as well as any Company insider trading policy, and the Participant should
consult his or her personal legal advisor on this matter.

Section 3.24    Imposition of Other Requirements. The Company reserves the right to impose other requirements on the
Participant’s  participation  in  the  Plan,  on  this  award  of  RSUs  and  on  any  Shares  received  from  the  RSUs,  to  the  extent  the
Company  determines  it  is  necessary  or  advisable  for  legal  or  administrative  reasons,  and  to  require  the  Participant  to  sign  any
additional agreements or undertakings that may be necessary to accomplish the foregoing.

[SIGNATURE PAGE FOLLOWS]

Exhibit 10.3(l)

IN WITNESS HEREOF, this Award Agreement has been executed and delivered by the parties hereto.

THE PARTICIPANT    
Electronic signature to be provided
and recorded via online grant
acceptance process on www.etrade.com

INTEGRA LIFESCIENCES
HOLDINGS CORPORATION

By                
Name:
Title:

 
 
                    
 
 
 
 
Exhibit 10.3(l)

EXHIBIT A

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
FIFTH AMENDED AND RESTATED
2003 EQUITY INCENTIVE PLAN

RESTRICTED STOCK UNIT AWARD AGREEMENT

NON-U.S. AND COUNTRY-SPECIFIC PROVISIONS

Terms and Conditions

This Exhibit A includes special terms and conditions applicable to the Participant if the Participant resides and/or works outside the
U.S. and, as applicable, in one of the countries listed below. These terms and conditions supplement or replace (as indicated) the
terms and conditions set forth in the Restricted Stock Unit Award Agreement to which it is attached. Capitalized terms used and not
defined in this Exhibit A will have the meanings set forth in the Restricted Stock Unit Award Agreement or the Plan, as applicable.

Notifications

This  Exhibit  A  also  includes  information  regarding  tax,  securities  law,  exchange  controls  and  certain  other  issues  of  which  the
Participant should be aware with respect to his or her participation in the Plan. The information is based on the exchange control,
securities  and  other  laws  in  effect  in  the  respective  countries  as  of  January  2022.  Such  laws  are  often  complex  and  change
frequently.  In  addition,  other  laws  and  regulations  generally  applicable  to  the  acquisition,  holding  or  disposal  of  securities  and
financial instruments as well as cross-border fund transfers may apply to the Participant. As a result, the Participant should not rely
on the information noted herein as the only source of information relating to the consequences of the Participant’s participation in
the Plan because the information may be out of date at the time the RSUs vest or the Participant receives or sells the Shares.

In addition, the information in this Exhibit A is general in nature and may not apply to the Participant’s particular situation. The
Company is not in a position to assure the Participant of any particular result. Accordingly, the Participant should seek appropriate
professional advice as to how the relevant laws in the Participant’s country apply to the Participant’s situation.

* * * * *

If  the  Participant  is  a  citizen  or  resident  of  a  country  other  than  the  one  in  which  the  Participant  is  currently  residing  and/or
working, transfers employment and/or residency after the date of grant, or is considered a resident of another country for local law
purposes, the terms and conditions and information contained herein may not be applicable to the Participant. The Company shall,
in its sole discretion, determine to what extent the terms and conditions herein shall apply to the Participant in such a case.

Exhibit 10.3(l)

EUROPEAN UNION/EUROPEAN ECONOMIC AREA

Terms and Conditions

If  the  Participant  resides  and/or  is  employed  in  the  European  Union/European  Economic  Area,  the  following  provision  replaces
Section 3.15 of the Award Agreement:

(a) General. The Company is located at 1100 Campus Road, Princeton, New Jersey 08540, United States of America and grants
awards  under  the  Plan  to  employees  of  the  Company  and  its  Related  Corporations  or  Affiliates  in  its  sole  discretion.  In
conjunction with the Company’s grant of the RSUs under the Plan to the Participant and its ongoing administration of such
awards,  the  Company  is  providing  the  following  information  about  its  data  collection,  processing  and  transfer  practices
(“Personal  Data  Activities”).  The  Participant  should  carefully  review  this  information  about  the  Company’s  Personal  Data
Activities.

(b) Data Collection, Processing and Usage. The Company collects, processes and uses the Participant’s personal data, including
the Participant’s name, home address, email address, and telephone number, date of birth, social insurance number or other
identification number, salary, citizenship, job title, any Shares or directorships held in the Company, and details of all RSUs or
any other equity compensation awards granted, canceled, exercised, vested, or outstanding in the Participant’s favor, which the
Company receives from the Participant or the Service Recipient. In granting the RSUs under the Plan, the Company will collect
the Participant’s personal data for purposes of allocating Shares and implementing, administering and managing the Plan. The
Company’s  legal  basis  for  the  collection,  processing  and  usage  of  the  Participant’s  personal  data  is  the  Company  legitimate
interest of managing the Plan and generally administering employee equity awards granted under the Plan, and to satisfy its
contractual  obligations  under  the  terms  of  the  Award  Agreement  and  this  Exhibit  A.  The  Participant’s  refusal  to  provide
personal data may affect the Participant’s ability to participate in the Plan.

(c) Stock Plan Administration Service Provider. The Company transfers the Participant’s personal data to E*TRADE Securities
LLC and its affiliated companies (“E*TRADE”), American Stock Transfer & Trust Company, LLC and its affiliated companies
(“AST”),  independent  service  providers  based  in  the  United  States,  which  assists  the  Company  with  the  implementation,
administration and management of the Plan (together, the “Stock Plan Administrator”). In the future, the Company may select
a different Stock Plan Administrator and share the Participant’s personal data with another company that serves in a similar
manner. The Stock Plan Administrator will open an account for the Participant to receive and trade Shares acquired under the
Plan. The Participant will be asked to agree on separate terms and data processing practices with the Stock Plan Administrator,
which is a condition to the Participant’s ability to participate in the Plan.

(d)  International  Data  Transfers.  The  Company  and  the  Stock  Plan  Administrator  are  based  in  the  United  States.  The
Participant  should  note  that  the  Participant’s  country  of  residence  has  enacted  data  privacy  laws  that  are  different  from  the
United States. The Participant understands and acknowledges that the United States has enacted data privacy laws that are less
protective or otherwise different from those applicable in the Participant’s country of residence. For  example,  an  appropriate
level of protection can be achieved by implementing safeguards such as the Standard Contractual Clauses adopted by the EU
Commission. The legal basis for the transfer of the Participant’s personal data from the Participant’s country of residence to the
Company  in  the  United  States  and  onward  transfer  of  the  Participant’s  personal  data  by  the  Company  to  the  Stock  Plan
Administrator will be based on the applicable

Exhibit 10.3(l)

data protection laws.  The Participant may request a copy of such appropriate safeguards at privacy@integralife.com.

1

(e) Data Retention. The Company will use the Participant’s personal data only as long as necessary to implement, administer
and manage the Participant’s participation in the Plan or as required to comply with legal or regulatory obligations, including,
without limitation, under tax and securities laws. When the Company no longer needs the Participant’s personal data for any of
the above purposes, which will generally be seven (7) years after he or she participates in the Plan, the Company will cease to
use the Participant’s personal data and remove it from its systems. If the Company keeps the Participant’s personal data longer,
it would be to satisfy legal or regulatory obligations and the Company’s legal basis would be relevant laws or regulations.

(f) Data Subject Rights. The Participant understands that he or she may have a number of rights under data privacy laws in the
Participant’s country of residence. Subject to the conditions  under applicable  law  and  depending  on  where  the  Participant  is
based, such rights may include the right to (i) request access to, or copies of, the Participant’s personal data processed by the
Company,  (ii)  rectification  of  incorrect  personal  data  of  the  Participant,  (iii)  deletion  of  the  Participant’s  personal  data,  (iv)
restrictions on the processing of the Participant’s personal data, (v) object to the processing of the Participant’s personal data
for legitimate interests, (vi) portability of the Participant’s personal data, (vii) lodge complaints with competent authorities in the
Participant’s country of residence, and/or to (viii) receive a list with the names and addresses of any potential recipients of the
Participant’s personal data. To receive clarification regarding these rights or to exercise these rights, the Participant can contact
privacy@integralife.com.

(g)  Necessary  Disclosure  of  Personal  Data.  The  Participant  understands  that  providing  the  Company  with  the  Participant’s
personal  data  is  necessary  for  the  performance  of  the  Award  Agreement  and  that  the  Participant’s  refusal  to  provide  the
Participant’s personal data would make it impossible for the Company to perform its contractual obligations and may affect the
Participant’s ability to participate in the Plan.

AUSTRALIA

Terms and Conditions

Nature of Plan and the RSUs. The Plan is a plan to which Subdivision 83A-C of the Income Tax Assessment Act 1997 (Cth) (the
“Act”) applies (subject to the conditions in that Act).

In addition, the offer of the RSUs is intended to comply with the provisions of the Corporations Act 2001, Australian Securities and
Investments Commission (“ASIC”)  Regulatory  Guide  49  and  ASIC  Class  Order  14/1000.  Additional  details  are  set  forth  in  the
Offer Document for the Offer of RSUs to Australian Resident Employees.

Notifications

Exchange Control Information. Exchange control reporting is required for cash transactions exceeding A$10,000 and international
fund transfers of any amount. The Australian bank

1
 NTD: Integra’s data privacy team/counsel should confirm this is consistent with the company’s approach to data privacy compliance.

Exhibit 10.3(l)

assisting  with  the  transaction  will  file  the  report  for  the  Participant.  If  there  is  no  Australian  bank  involved  in  the  transfer,  the
Participant will be responsible for filing the report.

BELGIUM

Notifications

Foreign Asset/Account Reporting Information. The Participant will be required to report any securities (e.g., the  Shares  acquired
under the Plan) or bank accounts (including brokerage accounts) held outside of Belgium on the Participant’s annual tax return. The
Participant will also be required to complete a separate report providing the National Bank of Belgium with details regarding any
such account (including the account number, the name of the bank in which such account is held and the country in which such
account  is  located).  This  report,  as  well  as  additional  information  on  how  to  complete  it,  can  be  found  on  the  website  of  the
National Bank of Belgium, www.nbb.be, under Kredietcentrales / Centrales des crédits caption.

Stock  Exchange  Tax  Information.  A  stock  exchange  tax  applies  to  transactions  executed  by  a  Belgian  resident  through  a  non-
Belgian  financial  intermediary,  such  as  a  U.S.  broker.  The  stock  exchange  tax  will  apply  when  Shares  acquired  pursuant  to  the
RSUs  are  sold.  The  Participant  should  consult  with  a  personal  tax  or  financial  advisor  for  additional  details  on  the  Participant’s
obligations with respect to the stock exchange tax.

Annual  Securities  Account  Tax  Information.  A  new  “annual  securities  accounts  tax”  has  been  implemented,  which  imposes  a
0.15% annual tax on the value of qualifying securities held in a Belgian or foreign securities account. The tax will not apply unless
the total value of securities the Participant holds in such an account exceeds an average of €1 million on four reference dates within
the relevant reporting period (i.e., December 31, March 31, June 30 and September 30). Different payment obligations may apply,
depending on whether the securities account is held with a Belgian or foreign financial institution. The Participant should consult
with her or her personal tax advisor for more information regarding the annual securities accounts tax payment obligations.

CANADA

Terms and Conditions

RSUs and Dividend Equivalents Payable Only in Shares. In no event will the Participant receive a cash payment in connection with
the vesting and settlement of the RSUs or any dividend equivalents thereon.

Termination Date. This provision replaces Section 1.8 of the Award Agreement:

IMPORTANT:  For  purposes  of  the  RSUs,  in  the  event  of  the  termination  of  the  Participant’s  employment  or  service
relationship (whether or not later found to be invalid or unlawful for any reason, including for breaching either applicable
employment  laws  or  the  Participant’s  employment  agreement,  if  any),  unless  otherwise  required  by  applicable  legislation
and  unless  otherwise  provided  in  this  Section,  the  Participant’s  employment  or  service  relationship  will  be  considered
terminated  effective  as  of  the  date  that  is  the  earliest  of  (i)  the  date  the  Participant’s  employment  relationship  with  the
Company or any Affiliate is terminated, (ii) the date the Participant receives notice of termination from the Participant’s
employer, or (iii) the date the Participant is no longer actively providing services to the Company or any Affiliate, regardless
of  any  period  during  which  notice,  pay  in  lieu  of  notice  or  related  payments  or  damages  are  provided  or  required  to  be
provided under local law. The Participant will not earn or be entitled to any pro-rated vesting for

Exhibit 10.3(l)

that portion of time before the date on which the Participant’s right to vest terminates, nor will the Participant be entitled
to any compensation for lost vesting. The Committee shall have the exclusive discretion to determine when the Participant is
no  longer  providing  services  for  purposes  of  the  Participant’s  RSUs  (including  whether  the  Participant  may  still  be
considered to be providing services while on a leave of absence). Notwithstanding
the foregoing, if applicable employment standards legislation explicitly requires continued entitlement to vesting during a
statutory notice period, the Participant’s right to vest in the RSUs under the Plan, if any, will terminate effective as of the
last day of the Participant’s minimum statutory notice period, but the Participant will not earn or be entitled to pro-rated
vesting if the vesting date falls after the end of the Participant’s statutory notice period, nor will the Participant be entitled
to any compensation for lost vesting;

The following provisions will also apply if the Participant is a resident of Quebec:

Language Consent. The parties acknowledge that it is their express wish that the Award Agreement, including this Exhibit A, as
well  as  all  documents,  notices,  and  legal  proceedings  entered  into,  given  or  instituted  pursuant  hereto  or  relating  directly  or
indirectly hereto, be drawn up in English.

Consentement Relatif à la Langue Utilisée. Les parties reconnaissent avoir expressément souhaité que la convention ainsi que cette
Exhibit A, ainsi que tous les documents, avis et procédures judiciares, éxécutés, donnés ou intentés en vertu de, ou liés directement
ou indirectement à la présente convention, soient rédigés en langue anglaise.

Data Privacy. This provision supplements Section 3.15 of the Award Agreement:

The  Participant  hereby  authorizes  the  Company  and  the  Company’s  representatives  to  discuss  with  and  obtain  all  relevant
information from all personnel, professional or not, involved in the administration and operation of the Plan. The Participant further
authorizes the Company and any Affiliate, as well as E*TRADE, AST or such other third party service provider as may be selected
by the Company to assist with the Plan, to disclose and discuss the Plan with their advisors. The Participant further authorizes the
Company, any Related Corporation and any Affiliate to record such information and to keep such information in the Participant’s
employee file.

Notifications

Securities  Law  Information.  The  Participant  is  permitted  to  sell  the  Shares  acquired  under  the  Plan  through  the  Company’s
designated broker, provided the resale of such Shares takes place outside of Canada through the facilities of a stock exchange on
which the Shares are listed. The Shares are currently listed on the NASDAQ Stock Market.

Foreign Asset/Account Reporting Information. Foreign specified property held by a Canadian resident must be reporting annually
on a Form T1135 (Foreign Income Verification Statement) if the total cost of the foreign specified property exceeds C$100,000 at
any  time  during  the  year.  Thus,  unvested  RSUs  must  be  reported  -  generally  at  a  nil  cost-  if  the  C$100,000  cost  threshold  is
exceeded because of other foreign specified property held by the Participant. When the Shares are acquired, their cost generally is
the adjusted cost base (“ACB”) of the Shares. The ACB would ordinarily equal the fair market value of the Shares at the time of
acquisition, but if the Participant owns other Shares, this ACB may need to be averaged with the ACB of the other Shares. The
Participant should consult with his or her personal legal advisor regarding what

Exhibit 10.3(l)

reporting obligations, if any, will apply to the Participant with respect to the Shares acquired under the Plan.

CHINA

Terms and Conditions

The following terms and conditions apply only if the Participant is subject to exchange control restrictions or regulations in China,
as determined by the Company in its sole discretion.

Compliance with Law. The following provision supplements Section 3(b) of the Plan:

The Participant acknowledges that the Participant’s participation in the Plan is subject to the Company obtaining approval from the
State Administration of Foreign Exchange (“SAFE”). Without limitation to the foregoing, the Participant understands and agrees
that  the  issuance  and  delivery  of  Shares  pursuant  to  the  RSUs  will  be  delayed  until  the  Company  obtains  such  approval  or  the
Committee has otherwise determined that the issuance of the Shares can be made in compliance with applicable laws.

Sale of Shares. To facilitate compliance with any applicable laws and regulations in China, the Participant agrees that the Company
(or  a  brokerage  firm  instructed  by  the  Company,  if  applicable)  is  entitled  to  (i)  sell  all  the  Shares  issued  to  the  Participant  at
settlement  (on  the  Participant’s  behalf  and  at  the  Participant’s  direction  pursuant  to  this  authorization),  either  at  the  time  of
settlement  or  when  the  Participant  ceases  employment  with  the  Service  Recipient,  or  at  such  other  time  determined  by  the
Company, or (ii) require that any Shares acquired under the Plan be held with a designated brokerage firm until such Shares are
sold.

The  Participant  also  agrees  to  sign  any  agreements,  forms  and/or  consents  that  may  be  reasonably  requested  by  the  Company
(or the Company’s designated brokerage firm) to effectuate the sale of the Shares and acknowledges that neither the Company nor
the  designated  brokerage  firm  is  under  any  obligation  to  arrange  for  such  sale  of  the  Shares  at  any  particular  price  (it  being
understood that the sale will occur at the then-current market price) and that brokerage fees or commissions may be incurred in any
such sale. In  any  event,  when  the  Shares  acquired  under  the  Plan  are  sold,  the  proceeds  of  the  sale  of  the  Shares,  less  any  Tax-
Related  Items  and  brokerage  fees  or  commissions,  will  be  remitted  to  the  Participant  in  accordance  with  applicable  exchange
control laws and regulations.

Termination of Employment.  The  Participant  acknowledges  and  agrees  that  any  Shares  acquired  under  the  Plan  and  held  in  the
Participant’s  brokerage  account  must  be  sold  within  sixty  (60)  days  following  termination  of  the  Participant’s  Employment,  or
within such other period as determined by the Company or required by SAFE (the “Mandatory Sale Date”). This  includes  any
Shares  that  vest  upon  the  Participant’s  termination  of  Employment.  The  Participant  understands  that  any  Shares  held  by  the
Participant that have not been sold by the Mandatory Sale Date will automatically be sold by the Company’s designated broker at
the Company’s direction (on the Participant’s behalf pursuant to this authorization without further consent), as described above.

Exchange Control Restrictions. By entering into this Award Agreement, the Participant acknowledges and agrees that pursuant to
local exchange control requirements, any Shares acquired upon vesting of the RSUs must be held in an account with the Company’s
designated broker and may not be transferred from such account. The Participant further understands that he or she is permitted to
sell Shares acquired under the Plan only through the Company’s designated broker. The Participant further understands and agrees
that, due to exchange control laws in China, the Participant must immediately repatriate the proceeds from the sale of Shares

Exhibit 10.3(l)

and any cash dividends paid on such Shares to China. The Participant understands that such repatriation of the proceeds will need to
be effected through a special exchange control account established by the Company or a Related Corporation or Affiliate, and the
Participant  hereby  consents  and  agrees  that  the  proceeds  from  the  sale  of  Shares  or  the  receipt  of  any  cash  dividends  may  be
transferred  to  such  special  account  prior  to  being  delivered  to  the  Participant.  The  Company  may  deliver  the  proceeds  to  the
Participant in U.S. dollars or local currency at the Company’s discretion. If the proceeds are paid in U.S. dollars, the Participant
understands that he or she will be required to set up a U.S. dollar bank account in China so that the proceeds may be deposited into
this account. The Participant agrees to bear any currency fluctuation risk between the time the Shares are sold or dividends are paid
and the time the proceeds are distributed to the Participant. The Company is under no obligation to secure any particular exchange
conversion rate.

FRANCE

Terms and Conditions

Restricted Stock Units Not French-qualified. The RSUs granted under this Award Agreement are not intended to qualify for special
tax and social security treatment pursuant to Sections L. 225-197-1 to L. 225-197-5 and Sections L. 22-10-59 and L. 22-10-60 of
the French Commercial Code, as amended.

Language  Consent.  By  accepting  the  Award  Agreement,  the  Participant  confirms  having  read  and  understood  the  Plan  and  the
Award  Agreement,  which  were  provided  in  the  English  language.  The  Participant  accepts  the  terms  of  those  documents
accordingly.

Consentement Relatif à la Langue Utilisée. En acceptant cette Attribution, le Participant confirme avoir lu et comprendre le Plan et
ce Contrat qui ont été transmis en langue anglaise. Le Participant accepte les dispositions de ces documents en connaissance de
cause.

Notifications

Foreign  Asset/Account  Reporting  Information.  French  residents  holding  cash  or  securities  (including  Shares  acquired  under  the
Plan) outside of France or maintaining foreign bank or brokerage account (including accounts opened or closed during the tax year)
must declare such assets and accounts to the French tax authorities when filing an annual tax return. Failure to comply could trigger
significant penalties.

GERMANY

Notifications

Exchange Control Information. The Participant must report any cross-border payments in excess of €12,500 to the German Federal
Bank  (Bundesbank).  The  report  must  be  filed  electronically  and  the  form  of  report  (Allgemeine  Meldeportal  Statistik)  can  be
accessed  via  the  Bundesbank’s  website  (www.bundesbank.de).  The  Participant  is  responsible  for  complying  with  applicable
reporting obligations and should consult his or her personal legal advisor on this matter.

Foreign  Asset/Account  Reporting  Information.  If  the  Participant’s  acquisition  of  Shares  under  the  Plan  leads  to  a  “qualified
participation” at any point during the calendar year, the Participant must report the acquisition when he or she files a tax return for
the relevant year. A “qualified participation” is attained if (i) the value of the Shares acquired exceeds €150,000, or (ii) in the

Exhibit 10.3(l)

unlikely event the Participant holds Shares exceeding 10% of the Company’s total common stock.

IRELAND

There are no country-specific provisions.

ITALY

Terms and Conditions

Plan Document Acknowledgment. By  accepting  the  Award  Agreement,  the  Participant  further  acknowledges  that  the  Participant
has received a copy of the Plan, has reviewed the Plan and the Award Agreement in their entirety and fully understands and accepts
all  provisions  of  the  Plan  and  the  Award  Agreement.  The  Participant  further  acknowledges  that  the  Participant  has  read  and
specifically  and  expressly  approves,  without  limitation,  the  following  sections  of  the  Award  Agreement:  “Vesting  of  RSUs”;
“Responsibility  for  Taxes”;  “Electronic  Delivery  and  Participation”;  “Insider  Trading  Restrictions;  Market  Abuse  Laws”;
“Imposition  of  Other  Requirements”;  “Nature  of  Grant”;  and  “Foreign  Asset/Account,  Exchange  Control  and  Tax  Reporting”
(including the “Foreign Asset/Account Reporting Information” and “Foreign Asset Tax Information” below).

Notifications

Foreign  Asset/Account  Reporting  Information. If  the  Participant  holds  investments  abroad  or  foreign  financial  assets  (e.g.,  cash,
Shares) that may generate income taxable in Italy, the Participant is required to report them on his or her annual tax return (UNICO
Form, RW Schedule) or on a special form if no tax return is due. The same reporting duties apply if the Participant is the beneficial
owner of the investments, even if the Participant does not directly hold investments abroad or foreign assets.

Foreign Asset Tax Information. The  value  of  the  financial  assets  held  outside  of  Italy  by  Italian  residents  is  subject  to  a  foreign
asset tax. Such tax is currently levied at an annual rate of 2 per thousand (0.2%). The taxable amount will be the fair market value
of the financial assets (e.g., Shares) assessed at the end of the calendar year. No tax payment duties arise if the value of the foreign
assets held abroad does not exceed a certain threshold.

JAPAN

Notifications

Exchange  Control  Information.  If  Participant  acquires  Shares  valued  at  more  than  ¥100,000,000  in  a  single  transaction,  the
Participant must file a Securities Acquisition Report with the Ministry of Finance through the Bank of Japan within 20 days of the
acquisition of the Shares.

Foreign Asset/Account Reporting Information. The Participant will be required to report details of any assets (such as Shares) held
outside  of  Japan  as  of  December  31st  to  the  extent  such  assets  have  a  total  net  fair  market  value  exceeding  ¥50,000,000.  Such
report will be due by March 15th each year. The Participant should consult with his or her personal tax advisor as to whether the
reporting obligation extends to any outstanding RSUs held by the Participant and to ensure compliance with applicable reporting
obligations.

MEXICO

Exhibit 10.3(l)

Terms and Conditions

Acceptance of the Award Agreement: By accepting the RSUs, the Participant acknowledges that he or she has received a copy of
the  Plan  and  the  Award  Agreement,  including  this  Exhibit,  which  the  Participant  has  reviewed.  The  Participant  acknowledges
further that he or she accepts all the provisions of the Plan and the Award Agreement, including this Exhibit. The Participant also
acknowledges that he or she has read and specifically and expressly approves the terms and conditions set forth in Section 3.3 of
the Award Agreement, which clearly provide as follows:

(1)    the Participant’s participation in the Plan does not constitute an acquired right;

(2)    The Plan and the Participant’s participation in it are offered by the Company on a wholly discretionary basis; and

(3)    the Participant’s participation in the Plan is voluntary.

Labor  Law  Policy  and  Acknowledgement:  In  accepting  the  RSUs,  Participant  expressly  recognizes  that  Integra  LifeSciences
Holdings Corporation at 1100 Campus Road, Princeton, New Jersey 08540, USA, is solely responsible for the administration of the
Plan and that the Participant’s participation in the Plan and acquisition of the Shares do not constitute an employment relationship
between the Participant and the Company since the Participant is participating in the Plan on a wholly commercial basis and the
Participant’s sole employer is a Mexican subsidiary of the Company (“Integra-Mexico”). Based on the foregoing, the Participant
expressly recognizes that the Plan and the benefits that the Participant may derive from his or her participation in the Plan do not
establish any rights between the Participant and Integra-Mexico, and do not form part of the employment conditions and/or benefits
provided by Integra-Mexico and any modification of the Plan or its termination shall not constitute a change or impairment of the
terms and conditions of the Participant’s employment.

The Participant further understands that his or her participation in the Plan is a result of a unilateral and discretionary decision of
the Company; therefore, the Company reserves the absolute right to amend and/or discontinue the Participant’s participation at any
time without any liability to the Participant.

Finally, the Participant hereby declares that he or she does not reserve any action or right to bring any claim against the Company
for any compensation or damages regarding any provision of the Plan or the benefits derived under the Plan, and the Participant
therefore grants a full and broad release to the Company, its subsidiaries, branches, representation offices, its shareholders, officers,
agents or legal representatives with respect to any claim that may arise.

Spanish Translation

Reconocimiento del Acuerdo

Aceptando  este  Premio  (Award),  el  Participante  reconoce  que  ha  recibido  una  copia  del  Plan,  el  Anuncio  de  la  Subvención  y  el
Acuerdo, con inclusión de este Apéndice, que el Participante ha revisado. El Participante reconoce, además, que acepta todas las
disposiciones del Plan, el Anuncio de la Subvención, y en el Acuerdo, incluyendo este Apéndice. El Participante también reconoce
que ha leído y que concretamente aprueba de forma expresa los términos y condiciones establecidos en la Sección 3.3 del Acuerdo,
que claramente dispone lo siguiente:

(1)    La participación del Participante en el Plan no constituye un derecho adquirido;

Exhibit 10.3(l)

(2)    El Plan y la participación del Participante en el Plan se ofrecen por la Compañía en su discrecionalidad total; y

(3)    Que la participación del Participante en el Plan es voluntaria.

Política de la Ley Laboral y Reconocimiento

Aceptando  este  Premio  (Award),  el  Participante  reconoce  expresamente  que  Integra  LifeSciences  Holdings  Corporation  con
oficinas registradas ubicadas en 1100 Campus Road, Princeton, New Jersey 08540, en los Estados Unidos de América, es el único
responsable  de  la  administración  del  Plan  y  que  participación  del  Participante  en  el  mismo  y  la  adquisición  de  acciones  no
constituye de ninguna manera una relación laboral entre el Participante y la Compañía, debido a que la participación de esa persona
en el Plan deriva únicamente de una relación comercial y el único Patrón del participante es una afiliada Mexicana de la Compañía
(“Integra-México”).  Derivado  de  lo  anterior,  el  Participante  reconoce  expresamente  que  el  Plan  y  los  beneficios  que  pudieran
derivar para el Participante por su participación en el mismo, no establecen ningún derecho entre el Participante e Integra-México,
y no forman parte de las condiciones laborales y/o prestaciones otorgadas por Integra-México, y cualquier modificación al Plan o la
terminación  del  mismo  de  ninguna  manera  podrá  ser  interpretada  como  una  modificación  o  desmejora  de  los  términos  y
condiciones de trabajo del Participante.
Asimismo,  el  Participante  reconoce  que  su  participación  en  el  Plan  es  resultado  de  la  decisión  unilateral  y  discrecional  de  la
Compañía, por lo tanto, la Compañía se reserva el derecho absoluto para modificar y/o discontinuar la participación del Participante
en cualquier momento, sin ninguna responsabilidad hacia el Participante.

Finalmente  el  Participante  manifiesta  que  no  se  reserva  ninguna  acción  o  derecho  que  ejercitar  en  contra  de  la  Compañía,  por
cualquier  compensación  o  daños  o  perjuicios  en  relación  con  cualquier  disposición  del  Plan  o  de  los  beneficios  derivados  del
mismo, y en consecuencia exime amplia y completamente a la Compañía, sus afiliadas, sucursales, oficinas de representación, sus
accionistas, administradores, agentes y representantes legales con respecto a cualquier reclamo que pudiera surgir.

Notifications
Securities Law Information. The RSUs and Shares offered under the Plan have not been registered with the National Register of
Securities  maintained  by  the  Mexican  National  Banking  and  Securities  Commission  and  cannot  be  offered  or  sold  publicly  in
Mexico. In addition, the Plan, the Award Agreement, and any other document relating to the RSUs and Shares may not be publicly
distributed in Mexico. These materials are addressed to you only because of your existing relationship with the Company and these
materials  should  not  be  reproduced  or  copied  in  any  form.  The  offer  contained  in  these  materials  does  not  constitute  a  public
offering of securities but rather constitutes a private placement of securities addressed specifically to individuals who are present
employees of Integra-Mexico made in accordance with the provisions of the Mexican Securities Market Law, and any rights under
such offering shall not be assigned or transferred.

SINGAPORE

Notifications

Securities Law Information. The grant of the RSUs is being made pursuant to the “Qualifying Person” exemption” under section
273(1)(f)  of  the  Securities  and  Futures  Act  (Chapter  289,  2006  Ed.)  (“SFA”).  The  Plan  has  not  been  lodged  or  registered  as  a
prospectus with the Monetary Authority of Singapore. The Participant should note that the RSUs are subject to section 257 of

Exhibit 10.3(l)

the SFA and the Participant should not make any subsequent sale of the Shares in Singapore or any offer of such subsequent sale of
the Shares subject to the RSUs in Singapore, unless such sale or offer is made (i) six months or more after the date of grant or (ii)
pursuant to the exemptions under Part XIII Division 1 Subdivision (4) (other than section 280) of the SFA, or any other applicable
provisions  of  the  SFA.  The  Company’s  Common  Stock  is  traded  on  the  NASDAQ  Stock  Market,  which  is  located  outside  of
Singapore, under the ticker symbol “IART” and the Shares acquired under the Plan may be sold through this exchange.

Director Reporting Information. If the Participant is a director (including an alternate, substitute or shadow director) of a Singapore
Affiliate, he or she is subject to certain notification requirements under the Singapore Companies Act, regardless of whether he or
she is a Singapore resident or employed in Singapore. Among these requirements is the obligation to notify the Singapore Affiliate
in  writing  when  the  Participant  receives  or  disposes  of  an  interest  in  the  Company,  Related  Corporation,  or  an  Affiliate  (e.g.,
Options, RSUs, Shares). These notifications must be made within two (2) business days of acquiring or disposing of any interest in
the Company, Related Corporation, or any Affiliate or within two (2) business days of becoming a director if such an interest exists
at that time.

SWITZERLAND

Notifications

Securities Law Information. Neither this Award Agreement nor any other materials relating to the offer of RSUs (i) constitutes a
prospectus  according  to  articles  35  et  seq.  of  the  Swiss  Federal  Act  on  Financial  Services  (“FinSA”),  (ii)  may  be  publicly
distributed  or  otherwise  made  publicly  available  in  Switzerland  to  any  person  other  than  an  employee  of  Integra  LifeSciences
Holdings  Corporation  or  one  of  its  Subsidiaries  or  (iii)  has  been  or  will  be  filed  with,  approved  or  supervised  by  any  Swiss
reviewing  body  according  to  article  51  of  FinSA  or  any  Swiss  regulatory  authority,  including  the  Swiss  Financial  Market
Supervisory Authority (“FINMA”).

UNITED KINGDOM

Terms and Conditions

Responsibility for Taxes. This provision supplements Section 3.4 of the Award Agreement:

Without limitation to Section 3.4 of the Award Agreement, the Participant hereby agrees that the Participant is liable for all Tax-
Related Items and hereby covenants to pay all such Tax-Related Items, as and when requested by the Company or if different, the
Service Recipient or by Her Majesty’s Revenue & Customs (“HRMC”) (or any other tax authority or any other relevant authority). 
The Participant also hereby agrees to indemnify and keep indemnified the Company and, if different, the Service Recipient against
any Tax-Related Items that they are required to pay or withhold or have paid or will pay to HMRC (or any other tax authority or
any other relevant authority) on the Participant’s behalf.

Notwithstanding the foregoing, if the Participant is a director or executive officer of the Company (within the meaning of Section
13(k) of the Exchange Act), the terms of the immediately foregoing provision will not apply. In the event that the Participant is a
director or executive officer of the Company and the income tax not collected from or paid by the Participant within ninety (90)
days of the end of the U.K. tax year in which an event giving rise to the indemnification described above occurs, the amount of any
uncollected  income  tax  may  constitute  a  benefit  to  the  Participant  on  which  additional  income  tax  and  National  Insurance
contributions (“NICs”) may be payable.  The Participant will be responsible for reporting and paying any income tax due on this
additional benefit directly to HMRC under the self-assessment

regime and for paying to the Company and/or the Service Recipient (as appropriate) the amount of any NICs due on this additional
benefit,  which  the  Company  and/or  the  Service  Recipient  may  recover  from  the  Participant  by  any  of  the  means  referred  to  in
Section 3.4 of the Award Agreement.

Exhibit 10.3(l)

Subsidiaries of Integra LifeSciences Holdings Corporation

EXHIBIT 21.1

Name of Subsidiary
ACell, Inc.
Arkis Biosciences Inc.
Ascension Orthopedics Limited
BIMECO, Inc.
BioD, LLC
BioDlogics, LLC
BioRecovery, LLC
CardioDyne, Inc.
Cathtec Incorporated
Caveangle Limited
Confluent Surgical, Inc.
Derma First Aid Products, Inc.
Derma Sciences Europe Limited
Derma Sciences, Inc.
EndoSolutions, Inc.
Fiber Imaging Technologies, Inc.
GMS, Gesellschaft f✔r medizinische Sondentechnik mbH
ILS Financing (Ireland) Limited
ILS Financing Corporation
ILS Services Switzerland Ltd.
ILS Surgical Investments, LLC
INS Sweden AB
Integra Burlington MA, Inc. (formerly known as Integra Radionics, Inc.)
Integra Canada ULC (formerly known as Canada Microsurgical ULC)
Integra CI, Inc.
Integra Euro Holdings, Inc.
Integra France Holdings SAS
Integra German Holdings GmbH
Integra GmbH
Integra Japan K.K.
Integra LifeSciences (Canada) Holdings, Inc.
Integra LifeSciences (Ireland) Limited

State or Country of Incorporation or Organization
Delaware
Delaware
United Kingdom
Florida
Delaware
Delaware
Delaware
Massachusetts
Massachusetts
United Kingdom
Delaware
Pennsylvania
United Kingdom
Delaware
Delaware
Massachusetts
Germany
Ireland
Delaware
Switzerland
Delaware
Sweden
Delaware
Canada
Cayman Islands
Delaware
France
Germany
Germany
Japan
Delaware
Ireland

 
Integra LifeSciences (Shanghai) Co., Ltd.
Integra LifeSciences Austria GmbH
Integra LifeSciences Brazil Ltda.
Integra LifeSciences Corporation
Integra LifeSciences Enterprises, LLLP
Integra LifeSciences Financing (Cyprus) Limited
Integra LifeSciences Italy S.r.l.
Integra LifeSciences Korea Ltd.
Integra LifeSciences Middle East FZ-LLC
Integra LifeSciences Production Corporation
Integra LifeSciences Sales LLC (f/k/a Integra Healthcare Products LLC)
Integra LifeSciences Services (France) SAS
Integra LifeSciences Shared Services (Ireland) Limited
Integra LifeSciences Singapore Pte. Ltd.
Integra LifeSciences Spain, S.L.
Integra LifeSciences Switzerland Sárl
Integra LifeSciences Taiwan Company Limited
Integra LS (Benelux) NV
Integra LS Mexico, S. DE R. L. DE C.V.
Integra Luxtec, Inc.
Integra ME GmbH
Integra MicroFrance SAS
Integra NeuroSciences (International), Inc.
Integra NeuroSciences Holdings (UK) Limited
Integra NeuroSciences Holdings B.V.
Integra NeuroSciences Implants (France) SAS
Integra NeuroSciences Limited
Integra Neurosciences Pty Ltd. (AUS)
Integra Neurosciences Pty Ltd. (NZ)
Integra Receivables LLC
Integra Sales, Inc.
Integra Selector LLC
Integra Switzerland Holdings Sarl
Integra York PA, Inc. (formerly known as Miltex, Inc.)
IsoTis NV
IsoTis T.E. Facility B.V.
J. Jamner Surgical Instruments, Inc.

China
Austria
Brazil
Delaware
Delaware
Cyprus
Italy
Korea
Dubai
Delaware
Delaware
France
Ireland
Singapore
Spain
Switzerland
Taiwan
Belgium
Mexico
Massachusetts
Germany
France
Delaware
United Kingdom
Netherlands
France
United Kingdom
Australia
New Zealand
Delaware
Delaware
Delaware
Switzerland
Delaware
Netherlands
Netherlands
Delaware

Jarit GmbH
LXU Healthcare, Inc. - Medical Specialty Products
MedEfficiency, Inc.
Minnesota Scientific, Inc.
Newdeal SAS
Newdeal, Inc.
Precise Dental Holding Corp.
Precise Dental Internacional, S.A. de C.V.
Precise Dental Products, Ltd.
Precision Dental International, Inc.
Rebound Therapeutics Corporation
Spembly Cryosurgery Limited
Spembly Medical Limited
Surgical Innovation Associates, Inc.
Tarsus Medical Inc.
TEI Biosciences (UK) Limited
TEI Biosciences Inc.
TEI Medical Inc.
TGX Medical Systems, LLC

Germany
Delaware
Delaware
Minnesota
France
Texas
New Jersey
Mexico
California
California
Delaware
United Kingdom
United Kingdom
Delaware
Delaware
United Kingdom
Delaware
Delaware
Delaware

EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 333-231709, 333-221210, 333-216212, 333-170210,
333-155263, 333-127488, 333-109042, 333-261744 and 333-266353) of Integra LifeSciences Holdings Corporation of our report dated February 22, 2023
relating to the financial statements, financial statement schedule and the effectiveness of internal control over financial reporting, which appears in this Form
10-K.

/s/ PricewaterhouseCoopers LLP
Florham Park, New Jersey
February 22, 2023

                                        
Exhibit 31.1

Certification of Principal Executive Officer
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

I, Jan De Witte, certify that:

1.

I have reviewed this annual report on Form 10-K of Integra LifeSciences Holdings Corporation;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The  registrant's  other  certifying  officer  and  I  are  responsible  for  establishing  and  maintaining  disclosure  controls  and  procedures  (as  defined  in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-
15(f)) for the registrant and we have:

(a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,
to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within
those entities, particularly during the period in which this report is being prepared;

(b) designed  such  internal  control  over  financial  reporting,  or  caused  such  internal  control  over  financial  reporting  to  be  designed  under  our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;

(c) evaluated  the  effectiveness  of  the  registrant's  disclosure  controls  and  procedures  and  presented  in  this  report  our  conclusions  about  the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) disclosed  in  this  report  any  change  in  the  registrant's  internal  control  over  financial  reporting  that  occurred  during  the  registrant's  most
recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely
to materially affect, the registrant's internal control over financial reporting; and

5.

 The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the
registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

(a) all  significant  deficiencies  and  material  weaknesses  in  the  design  or  operation  of  internal  control  over  financial  reporting  which  are

reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

(b) any  fraud,  whether  or  not  material,  that  involves  management  or  other  employees  who  have  a  significant  role  in  the  registrant's  internal

control over financial reporting.

Date:

February 22, 2023

/s/ Jan De Witte
Jan De Witte
President and Chief Executive Officer

 
Exhibit 31.2

Certification of Principal Financial Officer
Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

I, Jeffrey A. Mosebrook, certify that:

1.

I have reviewed this annual report on Form 10-K of Integra LifeSciences Holdings Corporation;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The  registrant's  other  certifying  officer  and  I  are  responsible  for  establishing  and  maintaining  disclosure  controls  and  procedures  (as  defined  in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-
15(f)) for the registrant and we have:

(a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision,
to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within
those entities, particularly during the period in which this report is being prepared;

(b) designed  such  internal  control  over  financial  reporting,  or  caused  such  internal  control  over  financial  reporting  to  be  designed  under  our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;

(c) evaluated  the  effectiveness  of  the  registrant's  disclosure  controls  and  procedures  and  presented  in  this  report  our  conclusions  about  the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) disclosed  in  this  report  any  change  in  the  registrant's  internal  control  over  financial  reporting  that  occurred  during  the  registrant's  most
recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely
to materially affect, the registrant's internal control over financial reporting; and

5.

 The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the
registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

(a) all  significant  deficiencies  and  material  weaknesses  in  the  design  or  operation  of  internal  control  over  financial  reporting  which  are

reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

(b) any  fraud,  whether  or  not  material,  that  involves  management  or  other  employees  who  have  a  significant  role  in  the  registrant's  internal

control over financial reporting.

Date:

February 22, 2023

/s/ Jeffrey A. Mosebrook
Jeffrey A. Mosebrook
Senior Vice President, Finance

Certification of Principal Executive Officer
Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 32.1

I, Jan De Witte, President and Chief Executive Officer of Integra LifeSciences Holdings Corporation (the “Company”), hereby certify that, to my knowledge:

1. The Annual Report on Form 10-K of the Company for the year ended December 31, 2022 (the “Report”) fully complies with the requirement of

Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date:

February 22, 2023

/s/ Jan De Witte
Jan De Witte
President and Chief Executive Officer

 
Certification of Principal Financial Officer
Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 32.2

I,  Jeffrey  A.  Mosebrook,  Senior  Vice  President,  Finance  of  Integra  LifeSciences  Holdings  Corporation  (the  “Company”),  hereby  certify  that,  to  my
knowledge:

1. The Annual Report on Form 10-K of the Company for the year ended December 31, 2022 (the “Report”) fully complies with the requirement of

Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date:

February 22, 2023

/s/ Jeffrey A. Mosebrook
Jeffrey A. Mosebrook
Senior Vice President, Finance