Invex Therapeutics Ltd
Annual Report 2022

Plain-text annual report

ANNUAL REPORT 2022 CONTENTS Corporate Highlights ................................................................................ 1 Market Highlights ....................................................................................... 2 Achievements .............................................................................................. 3 Chairman’s Letter ...................................................................................... 4 Directors’ Report ........................................................................................ 8 Auditor’s Independence Declaration .............................................. 20 Consolidated Statement of Profit or Loss and Other Comprehensive Income ................................................... 21 Consolidated Statement of Financial Position ........................... 22 Consolidated Statement of Changes in Equity .......................... 23 Consolidated Statement of Cash Flows ......................................... 24 Notes to the Financial Statements ................................................... 25 Directors’ Declaration ........................................................................... 43 Independent Auditor’s Report .......................................................... 44 Corporate Governance Statement ................................................... 47 ASX Additional Information ................................................................ 48 Corporate Directory ................................................................................. 51 COMPONENTS FOR INVEX’S SUCCESS MANUFACTURING Exclusive Agreement with Peptron, Inc. for 1x per week Presendin™ clinical and commercial supply. REGULATORY AU registration via TGA, UK registration via MHRA, European registration via EMA, U.S. clinical sites via FDA CLINICAL Single Phase III clinical trial designed with expert input. FUNDING $29.3 million cash – fully funds Phase III trial to registration. ii INVEX THERAPEUTICS LTD. CORPORATE HIGHLIGHTS $29.3 million cash $3.4m FY22 Operating Cash Burn $4.0m Net Loss after Tax $0.90m $2.6 Annual Corporate Investment into R&D overhead (excluding R&D and share-based compensation) 18% Directors and Management share ownership million >20 8 Core Invex team Consultants and delivering on Presendin™ advisors assisting Invex clinical and commercial in delivering Presendin™ pathways Phase III clinical trial ANNUAL REPORT 2022 1 MARKET HIGHLIGHTS $1.6 billion total annual addressable market for IIH in the EU, the UK and the US IIH Patients Report: 82% severe impact of headache on daily life1 3.4% annual growth in IIH incidence 77% 24k Annual number 16k Annual number frequent visual problems1 of newly diagnosed of newly diagnosed IIH patients (EU & UK) IIH patients (US) 49% felt their daily life was often severely impacted1 1. Witry, M., Kindler, C., Weller, J. et al. The patients’ perspective on the burden of idio- pathic intracranial hypertension. J Headache Pain 22, 67 (2021). 700+ neuro-ophthalmologists in key Invex target markets (US, AU, UK, EU) 2 INVEX THERAPEUTICS LTD. ACHIEVEMENTS IIH EVOLVE single Phase III clinical trial in Idiopathic Intracranial Hypertension (IIH) to meet regulatory requirements of the EMA, TGA and MHRA Peptron signed commercial agreement in September 2021 IIH EVOLVE the Phase III registration trial for Presendin™ in IIH Professor Michael Wall leading IIH key opinion leader and Trial Steering Group Chairperson for the IIH EVOLVE Phase III Clinical Trial Presendin™ the once per week sustained- release Exenatide formulation for clinical and commercial sale 12,000 patient doses per month at Peptron’s existing manufacturing facility in Osong, Korea Best Abstract 2022 NANOS Annual Meeting for Phase II PRESSURE trial WHAT IS IIH EVOLVE? Phase III Schematic 1 week screening 24 weeks Placebo, s.c., 1x weekly Presendin™, s.c., 1x weekly Study unblinded - Analysis of Primary, Secondary Endpoints IIH Evolve is a randomised, double-blind, placebo-controlled, multicentre clinical trial to determine the safety and efficacy of Presendin™ in the treatment of IIH. Change in Intracranial Pressure (ICP) from baseline at 24 weeks Change in Perimetric Mean Deviation (PMD) from baseline over 24 weeks Change in Optical Coherence Tomography (OCT) measures over 24 weeks Change in Monthly Headache Days (MHD) from baseline over 24 weeks Primary Endpoint Secondary Endpoint Secondary Endpoint Secondary Endpoint Safety Quality of Life Adverse events rate, anti-drug antibodies, PK and general lab measures 4 week safety follow-up No Treatment Patient reported outcomes (SF-36, ED-5D-5L, VFQ-25), monthly patient diary End of Trial s.c. means sub-cutaneous (under the skin) ANNUAL REPORT 2022 3 CHAIRMAN’S LETTER Dear Shareholders, On behalf of the Board of Invex Therapeutics Ltd (Invex, the Company) and its controlled entity (Group), I am pleased to present the Invex Annual Report to shareholders for the year ended 30 June 2022 (FY22). During FY22 Invex has been very focussed on completing the necessary clinical, regulatory and manufacturing requirements in order to commence a single Phase III clinical trial (IIH EVOLVE) of a once per week formulation of Exenatide – Presendin™ – for the treatment of Idiopathic Intracranial Hypertension (IIH). We have made excellent progress during FY22 and will be in a position to recruit patients across the United Kingdom (UK), Australia, the United States (US), Europe, New Zealand and Israel in FY23. Our aim is to secure initial regulatory approval for Presendin™ in the major markets of European Union (EU), the UK and Australia. IIH is a chronic condition that develops predominately in obese women of child bearing age, where intracranial pressure (ICP) in the brain elevates siginficantly, resulting in disabling daily headaches and in some cases permanent vision loss. There are currently no European Medicines Agency (EMA) and US Food and Drug Adminsitration (FDA) treatments approved for IIH. Hence, there is an urgent need to develop new drug treatments for these patients, who suffer from significant quality of life effects with IIH patients often requring multiple hospital admissions, representing a large cost to the healthcare system. The economic cost of IIH is very significant. For example, the annual cost of IIH to the health system in England has been calculated to be almost £500 million by 2030. In Scotland, the incidence of IIH has increased to approximately 40 per 100,000 in obese females. Invex estimates the IIH annual addressable market in the US and EU/UK to be around A$1.6 billion, with a treatable patient population of approximately 92,000 patients (based on prevalence of the disease). Our approach seeks to ameliorate elevated ICP and therefore prevent the downstream impacts on these patients’ vision and headaches. Long Term Manufacturing Partner Secured – Peptron In September 2021, Invex signed an exclusive long- term Collaboration and Manufacturing Agreement with Peptron, Inc. a biopharmaceutical company developing sustained-release peptide-based medicines based in Daejeon, Korea. Under the terms of the agreement, Peptron will provide Invex with access to its intellectual property, including an extensive preclinical and clinical data package, and GMP grade Presendin™ for all of its clinical trials in IIH as well as for commercial use, once Presendin™ is approved. The Agreement provides a defined price per dose for the global supply of Presendin™ for clinical studies and for the first ten years following the first commercial sale. In addition, Invex has granted Peptron an exclusive license to commercialise Presendin™ for IIH in Korea. In December, Invex successfully completed an independent Qualified Person (QP) Audit of Peptron’s manufacturing facility. A satisfactory QP Audit and the subsequent certification of manufactured batches of drug product by a QP is a requirement under European Union (EU) and UK law prior to importation of manufactured drug product into the EU and or the UK for clinical or commercial purposes. The completion of the QP Audit of Peptron and one of Peptron’s key suppliers of manufacturing material will facilitate the importation of Presendin™ and placebo doses into clinical sites in Europe and the UK participating in Invex’s IIH EVOLVE Phase III clinical trial. Following the successful QP audit, Invex placed an initial purchase order with Peptron for supply of a clinical batch of Presendin™ and placebo drug product for the IIH EVOLVE Phase III clinical trial. Completion of Clinical and Regulatory Strategy Following multiple interactions with global regulators and consultation with clinical advisory groups Invex announced a strategy aimed at bringing Presendin™ to market as quickly as possible by focusing on meeting the requirements for registration of Presendin™ in the EU, the UK and Australia utilising a trial design based on advice received from the European Medicines Agency 4 INVEX THERAPEUTICS LTD. (EMA), the UK Medicines and Healthcare products Regulatory Agency (MHRA) and US FDA. Data from IIH EVOLVE will then be used to further inform discussions with the US FDA regarding the regulatory pathway for registration of Presendin™ in the US market. Accordingly, the Group’s regulatory strategy will be sequential in nature in order to maximise the commercial opportunity and regulatory certainty. Regulatory Submissions Seeking Approval to Commence IIH EVOLVE Filed and Several Approved In December, Professor Michael Wall, MD was appointed as the Trial Steering Group Chairperson for the IIH EVOLVE Phase III clinical trial. Dr Wall is a Professor of Ophthalmology and Neurology at the University of Iowa College of Medicine and Director of the Iowa Visual Field Reading Center. He is a global key opinion leader in IIH having made a significant contribution to the clinical and scientific literature pertaining to the diagnosis, treatment and management of this disease and has led a significant number of important clinical trials in IIH. IIH EVOLVE is a placebo-controlled, double-blind trial that will randomise 240 patients with newly diagnosed IIH to determine the efficacy and safety of Presendin™ versus placebo, administered once weekly over 24 weeks. The primary endpoint of the trial is the change in intracranial pressure from baseline with key secondary endpoints related to vision and headache outcome measures. Invex intends to open up to 40 clinical sites globally. Information on the trial is available at clinicaltrials. gov under Identifier NCT05347147. In December 2021 Invex filed the first Human Research Ethics Committee (HREC) dossier in Australia seeking authorisation from an HREC representing several private hospitals in Australia. In parallel, Invex submitted a Clinical Trial Notification (CTN) to the Therapeutic Goods Administration (TGA). In early July, the Group secured HREC and TGA approvals. Associate Professor Celia Chen, Director at Vision SA, Consultant Ophthalmologist at Flinders Medical Centre will be a Principal Investigator for IIH EVOLVE in Australia. “We have made excellent progress during FY22 and will be in a position to recruit patients across the United Kingdom (UK), Australia, the United States (US), Europe, New Zealand and Israel in FY23. Our aim is to secure initial regulatory approval for Presendin™ in the major markets of European Union (EU), the UK and Australia.” Invex has commenced the initiation of Australian IIH EVOLVE clinical trial sites and remains on track to commence patient recruitment once separate institutional authorisations are completed and study drug/placebo is available on-site. Additionally, Invex filed an additional separate HREC application for a single public hospital in Australia. During the year, the Group made the necessary regulatory submissions to the UK MHRA through a Clinical Trial Authorisation (CTA). In late June 2022, Invex received notification the MHRA had approved the Group’s CTA to commence the IIH EVOLVE Phase III clinical trial in the UK, for patients with IIH. In addition, Invex received a favourable ethical opinion from a Research Ethics Committee (REC), which is also a requirement prior to commencing the trial. Invex also submitted its Investigational New Drug (IND) Application to the US FDA with the IND subsequently granted as announced to ASX on 19 August 2022. Invex has now received approvals to proceed with the IIH EVOLVE study from a number of key regulatory agencies and while this has been a major undertaking for the Group during the last financial year, Invex is now in a strong position to commence patient recruitment in the second half of the 2022 calendar year. 5 ANNUAL REPORT 2022“The Group is effectively structured utilising a global virtual business model, with a small number of highly experienced executives and employees based in the UK utilising additional expertise from clinical, regulatory and manufacturing consultants, as required, to progress our clinical program in Australia, the UK, Europe and the United States.” Intellectual Property Intellectual Property (IP) is key to Invex’s business. Our orphan drug designations for Exenatide in IIH in both the US and Europe provides Invex with seven and ten years market exclusivity, respectively, upon regulatory clearance being granted. These orphan designations were secured from the FDA and EMA in 2017. Invex continued to make solid progress in expanding its patent and other intellectual property protection for Exenatide in pressure related disorders of the brain, including IIH, as well as the Company’s trademark, Presendin™. During the year, the European Patent Office notified Invex on the intention to grant the Company a European patent, designated patent number EP3188747 and titled “Elevated Intracranial Pressure Treatment.” The patent was subsequently published on 8 September 2021. As with the Company’s issued US patent, this additional European patent covers the use of GLP-1 receptor agonists, including Exenatide, in reducing elevated ICP associated with IIH, with the patent providing protection until at least August 2035. The granting of this patent for Europe, alongside the Company’s issued patents in other major markets including the US and Japan provides broad IP protection as Invex progresses its clinical development plans for Presendin™. 6 COVID-19 The Coronavirus (COVID-19) pandemic continued to persist throughout the 2022 financial year, particularly in the first half, although country-wide lockdowns were avoided in the United Kingdom and elsewhere during the year. COVID-19 did not exhibit any significant adverse impact on the Group during the 2022 financial year, although, the Company did note some delays in completing a number of lead-in activities related to the IIH EVOLVE clinical trial as they related to manufacturing, assay development and regulatory turnaround times. The pandemic has also affected the Group’s ability to hold in-person negotiations with the Group’s manufacturing partner Peptron Inc. and limited travel for Group consultants and staff, which has been largely mitigated through the use of virtual meeting platforms. Financials The Group recorded a net loss after tax of $3.950 million for the year ended 30 June 2022 (FY22), an increase of 73% on the prior corresponding period (pcp). This was largely due to higher R&D costs of $2.642 million (FY21: $1.139 million), reflecting the necessary regulatory and clinical expenditure required to commence the IIH EVOLVE study, along with product manfuacturing costs of $0.327 million (FY21: NIL) associated with the purchase of drug product (Presendin™) and placebo from Peptron. In addition share-based payment expenses of $0.352 million (FY21: $0.562 million). The Group continued to prudently manage its cash reserves during the year, with an overall cash burn from operations for the 2022 financial year of $3.377 million (FY21: $1.678 million), including corporate and administrative overheads of $0.9 million (FY21: $0.74 million). Importantly, the Group is effectively structured utilising a global virtual business model, with a small number of highly experienced executives and employees based in the UK utilising additional expertise from clinical, regulatory and manufacturing consultants, as required, to progress our clinical program in Australia, the UK, Europe and the United States. INVEX THERAPEUTICS LTD.The Group remains in a strong financial position with cash and cash equivalents of $29.339 million as at 30 June 2022 (FY21: $32.777 million), which is sufficient to complete a Phase III pivotal trial for Presendin™ for registration purposes in IIH. Corporate Governance & Diversity There were no changes to the Board composition during the year. We were pleased to complete new agreements for Executive Directors, which included Professor Sinclair increasing her time commitment to the Group as a part-time employee. Professor Sinclair continues to provide expert input into the execution of the Group’s Phase III clinical trial and in the assessment of potential new clinical indications by leveraging Invex’s core strength in the treatment of pressure-related brain disorders with GLP-1 receptor agonists such as Presendin™ with academic centres of excellence. During the year, the Board updated its Skills Matrix, which highlighted the Board currently has most of the appropriate skills and knowledge, experience and diversity required for a company of its size. In addition, the Board undertook a performance evaluation review relating to the scope and structure of Board meetings, compliance, risk management and strategy. The review has provided the Board with some areas for improvement; however, there were no notable areas of material concern for the Board. Invex makes a significant commitment to diversity, by understanding all people are created differently and by accepting and respecting different points of views and leveraging them to learn from one another. Our small team has demonstrated an exceptional willingness to collaborate, engage and execute. Female representation at the Board level was 40%. Excluding the Executive Directors, 100% of Invex employees are female. Inclusive of Executive Directors, the representation is 83% female and 17% male. Concluding Remarks On behalf of the Board I would like to thank our employees, advisors and consultants for their significant efforts in advancing the IIH EVOLVE study and in particular for achieving approvals from key regulatory bodies such as the FDA, MHRA and TGA as well as for the overall solid progress we have made during the year. As Chairman, I fully appreciate that timelines in the drug development sector can seem long and arduous; however, we certainly thank shareholders for their support of the Group to date. Our aim is to build significant value for all shareholders, through careful clinical planning and execution to provide Presendin™ with every chance of clinical and commercial success. We are certainly excited by what the 2023 financial year holds for Invex shareholders and we look forward to keeping you apprised of our progress. Dr Jason Loveridge Non-Executive Chairman 7 ANNUAL REPORT 2022 Your Directors present their report together with the consolidated financial statements of the Invex Therapeutics Ltd (Invex or Company) and its controlled entity (Group) for the financial year ended 30 June 2022. DIRECTORS The name of the Directors in office for the year ended 30 June 2022 until the date of this report are as follows. All Directors were in office for the entire year unless otherwise stated. Dr Jason Loveridge Non-executive Chairman Appointed 8 March 2019 Dr Loveridge is a founder of Invex Therapeutics and also CEO of 4SC AG, a German publicly listed oncology company. He has more than 30 years of international experience across Europe, Asia and the US in senior management positions in life sciences companies and as an investment professional dealing in both privately held and publicly traded companies. Additionally, he has substantial transactional experience in the sale and partnering of biotechnology assets. Dr Loveridge graduated in Biochemistry and Microbiology from the University of New South Wales, Australia, and holds a Ph.D. in Biochemistry from the University of Adelaide, Australia. He is also a fellow of the Royal Society of Medicine. Dr Loveridge is not considered an independent Director. Current Directorships – Member of the Management Board of 4SC AG. Former Directorships in last three years - Director of Actinogen Medical Ltd. Interests in shares and options – 3,374,462 shares and 800,000 unlisted options. Professor Alexandra Sinclair Executive Director – Chief Scientific Officer Appointed 28 June 2019 Prof Alexandra Sinclair is a founder of Invex Therapeutics and a Clinician Scientist and practicing Neurology Consultant running the Translational Brain Science Group at the Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, UK. She runs the Headache service and Idiopathic Intracranial Hypertension Service at University Hospital Birmingham NHS Foundation Trust. Prof Sinclair pioneered the pre-clinical work identifying GLP-1RA’s as a novel therapeutic approach to reduce brain pressure which she then progressed into a successful phase 2 clinical trial. She runs a translational research group focussed on developing novel therapeutics with forward translation to improve patient care. She is a member of the British Medical Association, UK, the Association of British Neurologists (ABN), UK and a Fellow of the Royal College of Physicians, London. Professor Sinclair is a member of the board for the European Headache Federation and is on the scientific committees for the North American Neuro-Ophthalmology Society (NANOS). She is also a council member for the British Association for the Study of Headache (BASH). Professor Sinclair has served on the MRC Neuroscience and Mental Health Board and the Midland Neuroscience Teaching and Research Fund Board, as well as being Chair of the Brain Research UK Scientific Advisory Board. Previously, she was an elected board member of the IHS. She was on the research committee for the Association for British Neurologists and was also the previous patron of the patient charity IIH UK. Current directorships – None. Former directorships held in last three years – None. Interests in shares and options - 2,500,000 shares and 800,000 unlisted options. 8 INVEX THERAPEUTICS LTD. DIRECTORS’ REPORTDr Thomas Duthy Executive Director Appointed 1 October 2020 Dr Duthy has over 18 years of direct financial markets experience having worked in sell-side equity research, and senior executive roles across investor relations and corporate development. Dr Duthy is the Founder and CEO of Nemean Group Pty Ltd, a boutique corporate advisory and investor relations firm specialising in delivering value-added services across the life sciences, medical devices, healthcare, technology and emerging company sectors. Prior to establishing Nemean Group in October 2018, Dr Duthy was the Global Head of Investor Relations & Corporate Development at Sirtex Medical Limited (ASX:SRX), which was sold to CDH Investments in September 2018 for A$1.9 billion and remains the largest medical device transaction in Australian corporate history. Prior to Sirtex, Tom spent ten years as a leading sell-side Healthcare & Biotechnology analyst at Taylor Collison Limited, focused mainly on small cap companies. He is a Member of the Australian Institute of Company Directors (MAICD). Current directorships – None. Former directorships held in last three years – Respiri Limited. Interests in shares and options – 106,923 shares and 800,000 unlisted options. Dr Megan Baldwin Non-executive Director Appointed 16 February 2021 Dr Baldwin is CEO and Managing Director of Opthea Limited (ASX:OPT; NASDAQ:OPT), a late-stage biopharmaceutical company developing a novel therapy, OPT-302, to address the unmet need in the treatment of retinal eye diseases, including wet age-related macular degeneration (wet AMD). Under Dr Baldwin’s leadership, Opthea has rapidly advanced its ophthalmology program through Phase I and Phase II clinical development and in October 2020 completed a $180 million IPO and listing on the US NASDAQ exchange to progress two pivotal Phase III studies in wet AMD. Dr Baldwin is currently over-seeing the expansion of the company’s management team in the U.S. and preparing for commercialization of OPT-302. Dr Baldwin is an experienced biotechnology executive, having over 20 years’ experience working on therapeutic drug development programs for cancer and ophthalmic indications. Prior to Opthea, Dr Baldwin was employed at Genentech (now Roche) as a postdoctoral researcher before moving to Genentech’s commercial division. Dr Baldwin also serves on the Board of Ausbiotech as Deputy Chair. Dr Baldwin is considered an independent Director. Current directorships – Opthea Limited., Ausbiotech. Former directorships held in last three years – None. Interests in shares and options - 400,000 unlisted options. Mr David McAuliffe Non-executive Director Appointed 8 March 2019 Mr McAuliffe is an experienced company director and entrepreneur who has had over twenty years’ experience, mostly in the international biotechnology field. During that time, he was involved in numerous capital raisings and in-licensing of technologies. He is a founder of several companies in Australia, France and the United Kingdom, many of which have become public companies. Mr McAuliffe has an Honours degree in Law, a Bachelor of Pharmacy degree and is the President of the Dyslexia – Speld Foundation WA (Inc). Mr McAuliffe is considered an independent Director. Current directorships - 4DS Memory Limited. Former directorships held in last three years – None. Interests in shares and options - 3,350,001 shares and 200,000 unlisted options. 9 ANNUAL REPORT 2022DIRECTORS’ REPORT (CONT.)Ms Narelle Warren Company Secretary Ms Warren is a Chartered Accountant with over twenty years of corporate advisory, financial management and company secretarial experience.  Ms Warren has coordinated and assisted in numerous corporate transactions, including acquisitions, divestments and raising funds via private and public equity markets. She holds both a Bachelor of Laws and Bachelor of Commerce. PRINCIPAL ACTIVITY Invex is a biopharmaceutical Group focused on the repurposing of an already approved drug, Exenatide, for efficacious treatment of neurological conditions derived from or involving raised intracranial pressure (ICP). The Group’s primary focus is Idiopathic Intracranial Hypertension (IIH), a severe condition of predominately overweight women of childbearing age, which can lead to disabling headaches and in some patients, permanent vision loss. The Group’s lead program is the development of Presendin™ for IIH, which is currently at Phase III clinical stage. Presendin™ is a once per week, subcutaneous, sustained-release (SR) Exenatide microsphere formulation originally developed by Peptron, Inc. (KOSDAQ: 087010). Invex completed a Phase II trial in 2020 and expects to commence a single, Phase III clinical trial (“IIH EVOLVE”) designed to meet the requirements for market approval of Presendin™ for the treatment of IIH in the European Union (EU), United Kingdom (UK) and Australia during 2022. Presendin™ is the Group’s filed (and granted) trademark name for reformulated Exenatide. The principal activity of the Group during the period has been to plan and prepare to commence the Phase III IIH EVOLVE clinical trial. OPERATING RESULTS The result of the Group for the year ended 30 June 2022 was a loss of $3,950,183 (2021: $2,288,595 loss). The net loss of the Group predominantly related to Research & Development costs of $2,962,596 associated with the planning of the Phase III clinical trial, intellectual property prosecution, manufacturing costs and regulatory advice, administration and corporate costs of $900,286 and non-cash items; notably share- based payments of $352,390. REVIEW OF OPERATIONS The Group is well funded to meet its medium-term objectives, including the completion of a Phase III trial for Presendin™ in IIH, with the associated drug manufacture and supply for the Phase III trial. In addition, the Group may consider the commencement of a small Phase II study for Presendin™ in a second patient group. FY22 highlights include: • Granted key European patent for Exenatide • Execution of an exclusive long-term Collaboration and Manufacturing Agreement with Peptron, Inc • Completion of regulatory and clinical reviews – targeting single Phase III clinical trial for Presendin™ • Scientific presentations at leading neuro ophthalmology conferences in Europe and the US • Successful completion of Qualified Person (QP) audit of Peptron • First commercial order of Presendin™ for clinical trial purposes from Peptron • Regulatory submissions for IIH EVOLVE clinical trial in Australia, UK, US and Europe completed LIKELY DEVELOPMENTS The Group has undertaken a significant amount of clinical and regulatory preparative work during FY22 and anticipates the commencement of the Phase III IIH EVOLVE clinical trial across a number of countries in the second half of the 2022 calendar year. 10 INVEX THERAPEUTICS LTD. DIRECTORS’ REPORT (CONT.)DIVIDENDS No dividends were paid or recommended by the Directors since the commencement of the year. SIGNIFICANT CHANGES IN STATE OF AFFAIRS Other than as outlined above, there were no significant changes in the Group’s state of affairs during the year. MATTERS SUBSEQUENT TO THE END OF THE FINANCIAL YEAR On 1 July 2022, Carol Parish was appointed Chief Operating Officer (COO) at the Group. Until 30 June 2022, Carol held the role as Head of Clinical Operations. Carol has been a pharmaceutical professional for over 33 years within the Pharmaceutical/Biotech industry, where she has been accountable for all Phases of drug development in multiple therapy areas. Prior to joining Invex, Carol was the Global Clinical Operations Lead at Intercept Pharmaceuticals (NASDAQ: ICPT) and has held various senior clinical positions at Stiefel Laboratories (acquired by GlaxoSmithKline in 2009) including Senior Director, Global Clinical Development for a new drug product, including collaborating with GSK Japan and China. Additionally, Carol spent over 20 years at Merck & Co (NYSE:MRK) and Johnson & Johnson (NYSE:JNJ). No other significant events occurred after balance date which may affect either the Group’s operations or results of those operations or the Group’s state of affairs. MEETINGS OF DIRECTORS During the year the following Director meetings were held. Director Dr Jason Loveridge Prof Alexandra Sinclair Dr Thomas Duthy Mr David McAuliffe Dr Megan Baldwin Board Meetings Number Eligible to Attend Number Attended 8 8 8 8 8 8 7 8 8 8 ENVIRONMENTAL REGULATIONS The Group is not subject to significant environmental regulation in respect of its research and development activities. UNISSUED SHARES UNDER OPTION Unissued ordinary shares of Invex Therapeutics Ltd under option at the date of this report are as follows: Date Options Granted Expiry Date Exercise Price 22 November 2019 22 November 2023 21 January 2020 9 April 2020 20 October 2020 21 January 2023 9 April 2023 20 October 2023 18 November 2020 18 November 2023 8 April 2021 Total 8 April 2024 $0.60 $1.00 $0.60 $1.30 $1.30 $1.10 Number Under Option 2,200,000 750,000 60,000 400,000 800,000 400,000 4,610,000 11 ANNUAL REPORT 2022DIRECTORS’ REPORT (CONT.)INSURANCE OF OFFICERS AND INDEMNITIES Invex paid a premium to insure the directors and secretary of the Group. The liabilities insured are legal costs that may be incurred in defending civil or criminal proceedings that may be brought against the officers in their capacity as officers of entities in the Group, and any other payments arising from liabilities incurred by the officers in connection with such proceedings. This does not include such liabilities that arise from conduct involving a wilful breach of duty by the officers or the improper use by the officers of their position or of information to gain advantage for them or someone else or to cause detriment to the Group. It is not possible to apportion the premium between amounts relating to the insurance against legal costs and those relating to other liabilities. PROCEEDINGS ON BEHALF OF THE GROUP No person has applied to the Court under section 237 of the Corporations Act 2001 for leave to bring proceedings on behalf of the Group, or to intervene in any proceedings to which the Group is a party, for the purpose of taking responsibility on behalf of the Group for all or part of those proceedings. No proceedings have been brought or intervened in on behalf of the Group with leave of the Court under section 237 of the Corporations Act 2001. NON-AUDIT SERVICES The Group may decide to employ its auditor on assignments additional to their statutory audit duties where the auditor’s expertise and experience with the Group is important. During the year, other services were performed in addition to their statutory duties. The details of the amount paid are disclosed in Note 20 of the consolidated financial report. AUDITOR’S INDEPENDENCE DECLARATION A copy of the auditors’ independence declaration as required under section 307C of the Corporations Act 2001 is set out on the page following this Directors’ Report. ADDITIONAL INFORMATION The earnings of the consolidated entity to 30 June 2022 are summarised below: Sales revenue EBITDA EBIT Loss after income tax 2022 $ — 2021 $ — (3,950,183) (2,282,320) (3,950,183) (3,950,183) (2,282,320) (2,282,320) REMUNERATION REPORT - AUDITED The remuneration report outlines the remuneration arrangements which were in place during the year and remain in place as at the date of this report, for the Directors and Key Management Personnel of the Group. The information provided in this remuneration has been audited as required by section 308(3C) of the Corporations Act 2001. 12 INVEX THERAPEUTICS LTD. DIRECTORS’ REPORT (CONT.)KEY MANAGEMENT PERSONNEL Key Management Personnel are those persons who are responsible for directing and controlling the activities of the Group. The Board has determined that the key management personnel of the Group are the Non-executive Directors and Executives of Invex, whose details are set out below. The following Key Management Personnel during the period unless otherwise stated: Director Date of appointment/resignation Role Dr Jason Loveridge Appointed 8 March 2019 Prof Alexandra Sinclair Appointed 28 June 2019 Appointed 1 October 2020 Non-executive Chair Executive Director Executive Director Dr Thomas Duthy Dr Megan Baldwin David McAuliffe Narelle Warren Carol Parish Appointed 16 February 2021 Non-executive Director Appointed 8 March 2019 Appointed 8 March 2019 Appointed 1 July 2022 Non-executive Director CFO & Company Secretary Chief Operating Officer REMUNERATION POLICIES The Board has not elected to establish a remuneration committee. Given the size of the current Board remuneration matters will be considered and approved by the full Board. The following items will be considered and discussed as deemed necessary at the Board meetings: • recommend the terms and conditions of employment for the Executive Directors and Senior Officers; • undertake a review of the Executive Directors’ performance, at least annually, including setting with the Executive Directors goals for the coming year and reviewing progress in achieving those goals; • consider and report on the recommendations of the Executive Directors on the remuneration of all direct reports; and • develop and facilitate a process for Board and Director evaluation. Non-executive Director’s remuneration The compensation of Non-executive Directors is based on market practice, Director’s duties and the level of accountability. The compensation policy is designed to attract and retain competent and suitably qualified Non-executive Directors and aims to align Director’s interests with interests of shareholders. Non-executive Directors fees are paid a set fee plus statutory superannuation where appropriate, and are reimbursed for out-of-pocket expenses. The Chair’s fees are determined independently to the fees of Non-executive Directors based on comparative roles in the external market. The base fees are reviewed annually and were last reviewed at a recent Board meeting. Non-executive Directors’ fees are determined within an aggregate directors’ fee pool limit, which is periodically recommended for approval by shareholders. The current limit stands at $400,000 per annum and was approved by shareholders at its Annual General Meeting of shareholders in November 2021. A Director may also be paid fees or other amounts as the Directors determine if a Director performs special duties or otherwise performs services outside the scope of the ordinary duties of a Director. Executive remuneration In determining executive remuneration, the Board aims to ensure that remuneration practices are: • competitive and reasonable, enabling the company to attract and retain key talent; • aligned to the company’s strategic and business objectives and the creation of shareholder value; • transparent; and • acceptable to shareholders. 13 ANNUAL REPORT 2022DIRECTORS’ REPORT (CONT.)The executive remuneration framework has three components: • fixed annual compensation comprising salary or fees and benefits, including superannuation; • short-term performance incentives; and • long-term incentives through participation in the Invex Employee Share Option Plan. Fixed annual compensation Executives receive their base salary/fees and benefits structured as a total employment cost (TEC) package which may be delivered as a combination of cash and prescribed non-financial benefits at the executives’ discretion. Executives are offered a competitive base pay that comprises the fixed component of pay and rewards. Independent remuneration consultants provide analysis and advice to ensure base pay is set to reflect the market for a comparable role. Base pay for executives is reviewed annually to ensure the executive’s pay is competitive with the market. An executive’s pay is also reviewed on promotion. There are no guaranteed base pay increases included in any executives’ contracts. There are no short-term incentives outstanding. No benefits other than noted above are paid to Directors or management except as incurred in normal operations of the business. Short term incentives No benefits other than remuneration disclosed in the remuneration report are paid to Directors or management except as incurred in normal operations of the business. Long term incentives The Group’s current Employee Share Incentive Plan (ESIP) is designed to provide medium and long term incentives for all employees (including Non-executive and Executive Directors) and to attract and retain experienced Employees, Board Members and Executive Officers and provide motivation to make the Group more successful. As incentive securities granted to Directors and Employees are considered to represent the value of the services received over the vesting period of the incentive security, the assessed value of the options are recognised and expensed over the vesting period. Incentive securities vesting during the period of issue are fully expensed under the accounting standards. Other than incentive securities disclosed in the remuneration report there have been no options issued to Directors at the date of this financial report. Voting and comments made at the Company’s 2021 Annual General Meeting (AGM) At the 2021 AGM, 96.8% of the votes received supported the adoption of the remuneration report for the year ended 30 June 2021. The Company did not receive any specific feedback at the AGM regarding its remuneration practices. Remuneration consultants The Group did not engage any remuneration consultants during the year. The Group may engage independent remuneration consultants should it look to make any changes to director fee levels to ensure they are in line with market conditions and any decisions are made free from undue influence from members of the Group’s Key Management Personnel (KMP’s). Service agreements During the year the Company entered into revised agreements with Executives. Prof. Alexandra Sinclair entered into an employment agreement on the 27 January 2022, commencing 1 March 2022. Dr Thomas 14 INVEX THERAPEUTICS LTD. DIRECTORS’ REPORT (CONT.)Duthy entered into a deed of variation with the Company effective 1 April 2022. The details of the key terms of the revised agreements are set out below: Name Executive Directors Term of agreement Prof Alexandra Sinclair Open Remuneration Termination benefit £145,000 plus statutory pension duties Relevant notice periods apply, being 1 months’ notice with reason or 3 months without reason. Dr Thomas Duthy – appointed 1 October 2020 Open $180,000 Relevant notice periods apply, being 1 months’ notice with reason or 3 months without reason. The relative proportions of remuneration that are linked to performance and those that are fixed are as follows: Name Executive Directors Prof Alexandra Sinclair Dr Thomas Duthy Non-executive Directors Fixed remuneration 2022 Performance based remuneration (%) 2022 $315,373 $138,750 7.67 47.42 On appointment to the Board, all Non-executive Directors enter into a service agreement with the Company in the form of a letter of appointment. The letter summarises the Board’s policies and terms, including compensation, relevant to the director, and among other things: • the terms of the directors appointment, including governance, compliance with the Company’s Constitution, committee appointments, and re-election; • the directors duties, including disclosure obligations, exercising powers, use of office, attendance at meetings and commitment levels; • the fees payable, in line with shareholder approval, any other terms, timing of payments and entitlements to reimbursements; • insurance and indemnity; • disclosure obligations; and • confidentiality. Dr Jason Loveridge entered into a new Consultancy Agreement effective 1 February 2022. The Non- executive Director fees paid during the year: Name Non-Executive Directors Dr Jason Loveridge – Consultancy Dr Jason Loveridge - Non-executive Chairman fee Term of agreement Remuneration Termination benefit Open £110,000 Relevant notice periods apply, being 3 months’ notice without reason. Shareholder Approval by rotation $60,000 Nil Dr Megan Baldwin - Non-executive fee Shareholder Approval by rotation $50,000 David McAuliffe - Non-executive fee Shareholder Approval by rotation $50,000 Nil Nil 15 ANNUAL REPORT 2022DIRECTORS’ REPORT (CONT.)- t s o P e c n a m r o f r e P d e s a b - e r a h S t n e m y o p m e l e v a e L d e s a b l a t o T s t n e m y a p s t i f e n e b s e c n a w o l l a l s t i f e n e b e e y o p m e m r e t - t r o h S : l w o e b d n u o f e r a p u o r G e h t ’ f o s P M K e h t d n a s r o t c e r i D e h t f o n o i t a r e n u m e r e h t f o s l i a t e D l e n n o s r e P t n e m e g a n a M y e K f o n o i t a r e n u m e R 16 d n a l a u n n A g n i t l u s n o C & y r a l a s h s a C s u n o b h s a C s e e f 2 2 0 2 % 8 4 8 . . 3 7 2 6 8 5 . 1 1 $ 9 6 1 , 4 3 1 9 4 5 6 5 , 5 0 0 9 0 3 , $ 3 9 1 , 6 2 9 6 1 , 4 8 9 4 5 6 , s n o i t p O 0 4 3 2 . , 3 2 7 9 9 4 1 1 9 6 1 1 , 5 1 . 9 7 6 7 . 2 4 7 4 . 7 9 0 3 4 1 , 6 6 5 , 1 4 3 4 6 8 3 6 2 , , 7 2 5 8 4 7 7 9 0 3 1 , 3 9 1 , 6 2 4 1 1 , 5 2 1 4 0 4 4 6 1 , 0 0 2 2 . , 0 5 2 8 4 2 , 1 5 1 3 , 1 8 2 $ — — — — — — 7 6 4 7 6 4 7 6 4 - r e p u S s n o i s n e P n o i t a u n n a $ — — — — — — — — — L S L — — $ e e f 3 2 1 8 2 2 2 , , 2 1 8 2 2 2 — — 8 0 2 9 1 1 , 8 0 2 9 1 1 , 0 2 0 2 4 3 , $ — — — — — — — — — $ 0 0 0 0 6 , 0 0 0 0 5 , 0 0 0 0 5 , 0 0 0 0 6 1 , 1 0 0 0 0 3 1 , s r o t c e r i D e v i t u c e x e - n o N e g d i r e v o L n o s a J r D e v i t u c e x e - n o N l a t o T e f f i l u A c M d v a D i n e r r a W e l l e r a N s e v i t u c e x E s r o t c e r i D i l n w d a B n a g e M r D 8 9 6 5 9 1 , l i r i a c n S a r d n a x e A l f o r P 2 0 5 7 8 3 1 , , 8 4 4 4 6 4 8 4 4 4 2 6 , s M o t n o i t a e r n l i s i t n u o m a s i h T . 1 y h t u D s a m o h T r D s e v i t u c e x E l a t o T l a t o T d n a n e r r a W e l l i e r a N h c h w y t i t n e n a d t L y t P h c e t o B t p e c n o C o t i y n a p m o C e h t i y b d a p d n a y n a p m o C e h t h t i l w e o r d n a e c n a n F i , y r a t e r c e S y n a p m o C s n e r r a W ’ . d t L y t P p u o r G n a e m e N o t y n a p m o C e h t i y b d a p d n a y n a p m o C e h t h t i w e o r l ’ r o t c e r i D e v i t u c e x E s y h t u D r D o t n o i t a e r n l i s i t n u o m a s i h T . 2 . d t L i b m a r a W o t y n a p m o C e h t i y b d a p d n a y n a p m o C e h t h t i i w s e c v r e s g n i t l u s n o c ’ s e g d i r e v o L r D o t n o i t a e r n l i s i t n u o m a s i h T . 3 . s r o t c e r i d d n a l s r e d o h e r a h s e r a e f f i l u A c M d v a D i INVEX THERAPEUTICS LTD. DIRECTORS’ REPORT (CONT.)       % 9 5 7 4 . 4 9 2 5 . 0 0 . 1 4 . 7 3 4 3 9 5 7 4 . 0 4 4 5 . $ 1 8 1 , 6 8 2 2 1 6 2 4 , 5 4 0 3 8 , s n o i t p O $ 1 8 1 , 6 3 1 0 6 5 2 2 , 5 4 0 4 3 , $ — — 6 2 6 , 1 - r e p u S s n o i s n e P n o i t a u n n a 0 9 0 8 9 1 , 1 8 1 , 6 8 2 , 5 1 6 5 0 2 , 6 8 8 9 8 6 0 9 0 8 6 , 1 8 1 , 6 3 1 5 6 8 , 1 1 1 6 3 1 , 6 1 3 — — — — 8 3 8 , 1 1 4 6 8 7 2 9 1 , 6 2 6 , 1 0 2 6 4 . 4 2 7 , 1 0 1 , 1 , 2 2 9 8 0 5 6 2 6 , 1 $ — — — — — — — — — L S L $ e e f 3 0 0 0 0 9 , — — 0 0 0 0 9 , — — — — 0 0 0 0 9 , $ — — — — — — — — — - t s o P e c n a m r o f r e P d e s a b - e r a h S t n e m y o p m e l e v a e L d e s a b l a t o T s t n e m y a p s t i f e n e b s e c n a w o l l a l s t i f e n e b e e y o p m e m r e t - t r o h S $ 0 0 0 0 6 , 3 2 1 , 7 1 0 0 0 0 5 , 3 2 1 , 7 2 1 1 0 0 0 0 3 1 , s r o t c e r i D e v i t u c e x e - n o N e g d i r e v o L n o s a J r D e v i t u c e x e - n o N l a t o T e f f i l u A c M d v a D i n e r r a W e l l e r a N s e v i t u c e x E s r o t c e r i D i l n w d a B n a g e M r D 0 0 0 0 5 1 , i l r i a c n S a r d n a x e A l f o r P 2 0 5 7 3 9 , 0 5 7 3 7 3 , , 3 7 8 0 0 5 s M o t n o i t a e r n l i s i t n u o m a s i h T . 1 y h t u D s a m o h T r D s e v i t u c e x E l a t o T l a t o T d n a l a u n n A g n i t l u s n o C & y r a l a s h s a C s u n o b h s a C s e e f 1 2 0 2 . d t L y t P h c e t o B t p e c n o C o t i y n a p m o C e h t i y b d a p d n a y n a p m o C e h t h t i l w e o r d n a e c n a n F i , y r a t e r c e S y n a p m o C s n e r r a W ’ . d t L y t P p u o r G n a e m e N o t y n a p m o C e h t i y b d a p d n a y n a p m o C e h t h t i w e o r l ’ r o t c e r i D e v i t u c e x E s y h t u D r D o t n o i t a e r n l i s i t n u o m a s i h T . 2 . d t L i b m a r a W o t y n a p m o C e h t i y b d a p d n a y n a p m o C e h t h t i i w s e c v r e s g n i t l u s n o c ’ s e g d i r e v o L r D o t n o i t a e r n l i s i t n u o m a s i h T . 3 17 ANNUAL REPORT 2022DIRECTORS’ REPORT (CONT.)       SHARE-BASED COMPENSATION Incentive Securities The Company’s current Employee Incentive Plan (ESIP) was approved by Shareholders on 25 November 2021 and the previous Employee Incentive Option Plan (ESOP) was approved by the Board of Directors on 20 May 2019. The Incentive Plans are designed to provide medium and long term incentives for all employees (including Non-executive and Executive Directors) and to attract and retain experienced employees, board members and executive officers and provide motivation to make the Company more successful. Under the ESIP, participants have not yet been granted incentive securities. Incentive securities only vest if certain milestones are met. Participation in the plan is at the Board’s discretion and no individual has a contractual right to participate in the plan or to receive any guaranteed benefit. Any option may only be exercised after the option has vested and other conditions imposed by the Board have been satisfied. Options were granted under the ESOP for no consideration. Options granted under the ESOP carry no dividend or voting rights. When exercisable, shares allotted pursuant to the exercise of options will be allotted following receipt of relevant documentation and payments will rank equally with all other shares. As options granted to employees are considered to represent the value of the services received over the vesting period of the options, the assessed value of the options is recognised and expensed over the vesting period. Options vesting during the period of issue are fully expensed under the accounting standards. During the year 30 June 2022 no incentive securities were granted, no options were cancelled and no options were forfeited. Details of the share-based component issued during the year included in the remuneration are set out below. EQUITY INSTRUMENTS HELD BY KEY MANAGEMENT PERSONNEL Shareholdings The numbers of shares in the Company held during the year by each director or key management personnel of Invex, including their personally related parties are set out below. There were no shares granted during the reporting year as compensation. 2022 Name Directors Dr Jason Loveridge Prof. Alexandra Sinclair Dr Thomas Duthy David McAuliffe Dr Megan Baldwin Narelle Warren Total Balance at the start of the year 3,374,426 2,500,000 106,923 3,350,001 — 200,000 9,531,350 Capital Raising shares subscribed for On Market Purchases/ On appointment Balance at the end of the year Disposals — — — — — — — — — — — — — — — — — — — — — 3,374,426 2,500,000 106,923 3,350,001 — 200,000 9,531,350 18 INVEX THERAPEUTICS LTD. DIRECTORS’ REPORT (CONT.)Option holdings The number of options over ordinary shares in the Company held during the year by each director and KMP of Invex Therapeutics Ltd, including their personally related parties, are set out below. Balance at the start of the year Granted as compensation Exercised/ Expired Balance at end of the year Vested and exercisable Un-vested Fair value at grant date 2022 Name Directors and KMP’s Dr Jason Loveridge Prof Alexandra Sinclair Dr Thomas Duthy 800,000 800,000 800,000 David McAuliffe 200,000 Dr Megan Baldwin 400,000 Narelle Warren 400,000 Total 3,400,000 — — — — — — — — — — — — — 800,000 800,000 800,000 800,000 — — 800,000 400,000 400,000 200,000 200,000 — 400,000 200,000 200,000 400,000 400,000 — — 3,400,000 2,800,000 600,000 $0.42 $0.42 $0.32 $0.42 $0.33 $0.42 LOANS WITH KEY MANAGEMENT PERSONNEL There were no loans to or from key management personnel during the year ended 30 June 2022. OTHER TRANSACTIONS WITH KEY MANAGEMENT PERSONNEL There were no other services provided with key management personnel which are not disclosed. This is the end of the Remuneration Report. Signed in accordance with a resolution of the Board of Directors. David McAuliffe Non-executive Director Perth, Western Australia, 19 August 2022 19 ANNUAL REPORT 2022DIRECTORS’ REPORT (CONT.)AUDITORS’ INDEPENDENCE DECLARATION Tel: +61 8 6382 4600 Fax: +61 8 6382 4601 www.bdo.com.au Level 9, Mia Yellagonga Tower 2 5 Spring Street Perth WA 6000 PO Box 700 West Perth WA 6872 Australia DECLARATION OF INDEPENDENCE BY JARRAD PRUE TO THE DIRECTORS OF INVEX THERAPEUTICS LTD As lead auditor of Invex Therapeutics Ltd for the year ended 30 June 2022, I declare that, to the best of my knowledge and belief, there have been: 1. No contraventions of the auditor independence requirements of the Corporations Act 2001 in relation to the audit; and 2. No contraventions of any applicable code of professional conduct in relation to the audit. This declaration is in respect of Invex Therapeutics Ltd and the entity it controlled during the period. Jarrad Prue Director BDO Audit (WA) Pty Ltd Perth 19 August 2022 BDO Audit (WA) Pty Ltd ABN 79 112 284 787 is a member of a national association of independent entities which are all members of BDO Australia Ltd ABN 77 050 110 275, an Australian company limited by guarantee. BDO Audit (WA) Pty Ltd and BDO Australia Ltd are members of BDO International Ltd, a UK company limited by guarantee, and form part of the international BDO network of independent member firms. Liability limited by a scheme approved under Professional Standards Legislation. 20 INVEX THERAPEUTICS LTD. CONSOLIDATED STATEMENT OF PROFIT OR LOSS AND OTHER COMPREHENSIVE INCOME FOR THE YEAR ENDED 30 JUNE 2022 Other income Research and development expenditure Finance, compliance and administration expenses Share-based payment expenses Loss before income tax from continuing operations Income tax expense/benefit Note 2022 $ 2021 $ 4 5 5 17 6 262,132 158,785 (2,962,596) (1,139,222) (900,286) (740,752) (352,390) (562,723) (3,953,140) (2,283,911) — — Loss for the year from continuing operations (3,953,140) (2,283,911) Other comprehensive income for the year, net of tax Items that may be reclassified subsequently to profit or loss Exchange differences on translation of foreign operations, net of tax Total other comprehensive income for the year, net of tax attributable to members of the Group Loss for the year is attributable to: Owners of Invex Therapeutics Ltd — 2,957 — 1,591 (3,950,183) (2,282,320) (3,950,183) (2,282,320) Total comprehensive income for the year is attributable to: Owners of Invex Therapeutics Ltd (3,950,183) (2,282,320) Loss per share (cents) 11 (5.26) (3.04) The above Consolidated Statement of Profit or Loss and Other Comprehensive Income should be read in conjunction with the accompanying notes. 21 ANNUAL REPORT 2022CONSOLIDATED STATEMENT OF FINANCIAL POSITION AS AT 30 JUNE 2022 ASSETS Current Assets Cash and cash equivalents 7 29,339,382 32,716,091 Note 2022 $ 2021 $ Other receivables Total Current Assets TOTAL ASSETS LIABILITIES Current Liabilities Trade and other payables Total Current Liabilities TOTAL LIABILITIES NET ASSETS EQUITY Contributed equity Reserves Accumulated losses TOTAL EQUITY 145,715 21,199 29,485,097 32,737,290 29,485,097 32,737,290 8 1,004,214 1,004,214 1,004,214 658,614 658,614 658,614 28,480,883 32,078,676 9 10 11 36,413,432 36,413,432 1,896,903 1,541,556 (9,829,452) (5,876,312) 28,480,883 32,078,676 The above Consolidated Statement of Financial Position should be read in conjunction with the accompanying notes. 22 INVEX THERAPEUTICS LTD. CONSOLIDATED STATEMENT OF CHANGES IN EQUITY FOR THE YEAR ENDED 30 JUNE 2022 Contributed Equity $ Accumulated Losses $ Reserves Total Equity $ Balance as at 1 July 2021 36,413,432 (5,876,312) 1,541,556 32,078,676 (Loss) for the year Other comprehensive income for the year Fx reserve movement Total comprehensive (loss) for the year Share-based payment reserve movement Transactions with owners in their capacity as owners: Issue of share capital, net of transaction costs — — — — — — (3,953,140) — — (3,953,140) — — — — — 2,957 2,957 (3,953,140) — 2,957 (3,950,183) 352,390 352,390 — — — — Balance as at 30 June 2022 36,413,432 (9,829,452) 1,896,903 28,480,883 Contributed Equity $ Accumulated Losses $ Reserves Total Equity $ Balance as at 1 July 2020 27,017,127 (3,592,401) 977,242 24,401,968 (Loss) for the year Other comprehensive income for the year Fx reserve movement Total comprehensive (loss) for the year Share-based payment reserve movement Transactions with owners in their capacity as owners: — — — — — — Issue of share capital, net of transaction costs 9,396,305 (2,283,911) — — — — 1,591 (2,283,911) — 1,591 (2,283,911) 1,591 (2,282,320) — — — 562,723 562,723 — — — 9,396,305 Balance as at 30 June 2021 36,413,432 (5,876,312) 1,541,556 32,078,676 The above Consolidated Statement of Changes in Equity should be read in conjunction with the accompanying notes. 23 ANNUAL REPORT 2022CONSOLIDATED STATEMENT OF CASH FLOWS FOR THE YEAR ENDED 30 JUNE 2022 CASH FLOWS FROM OPERATING ACTIVITIES Payments to suppliers and employees R&D Tax rebate Interest received Net cash outflow from operating activities CASH FLOWS FROM FINANCING ACTIVITIES Subscription proceeds received for ordinary shares Placement capital raising costs Net cash inflow from financing activities Note 2022 $ 2021 $ (3,638,841) (1,837,030) 182,251 79,881 — 158,785 (3,376,709) (1,678,245) — — — 8,647,547 (553,670) 8,093,877 Net increase/(decrease) in cash and cash equivalents held Cash and cash equivalents at the beginning of the year (3,376,709) 6,415,632 32,716,091 26,300,459 Cash and cash equivalents at end of financial year 7 29,339,382 32,716,091 The above Consolidated Statement of Cash Flows should be read in conjunction with accompanying the notes. 24 INVEX THERAPEUTICS LTD. 1. BASIS OF PREPARATION The financial report is a general purpose financial report that has been prepared in accordance with Australian Accounting Standards, Australian Accounting Interpretations, other authoritative pronouncements of the Australian Accounting Standards Board and the Corporations Act 2001. Invex Therapeutics Ltd is a listed public company, incorporated and domiciled in Australia and is the parent entity. Invex Therapeutics Ltd is a for-profit entity for the purpose of preparing the financial statements. These consolidated financial statements comprise the Company and its controlled entity at the end of, or during the year (together referred to as ‘the Group’) and were authorised for issue by the Board of Directors. Australian Accounting Standards set out accounting policies that the AASB has concluded would result in a financial report containing relevant and reliable information about transactions, events and conditions. Compliance with Australian Accounting Standards ensures that the financial statements and notes also comply with International Financial Reporting Standards as issued by the IASB. Material accounting policies adopted in the preparation of this financial report are presented below and have been consistently applied unless otherwise stated. The financial report has been prepared on an accruals basis and is based on historical costs, modified, where applicable, by the measurement at fair value of selected non-current assets, financial assets and financial liabilities. 2. NEW AND AMENDED ACCOUNTING STANDARDS AND INTERPRETATIONS The consolidated entity has adopted all of the new or amended Accounting Standards and Interpretations issued by the Australian Accounting Standards Board ('AASB') that are mandatory for the current reporting period. Any new or amended Accounting Standards or Interpretations that are not yet mandatory have not been early adopted. 3. SUMMARY OF ACCOUNTING POLICIES The following material accounting policies adopted by the Group in the preparation of the financial report, have been consistently applied unless otherwise stated. (a) Parent entity information In accordance with the Corporations Act 2001, these financial statements present the results of the consolidated entity only. Supplementary information about the parent entity is disclosed in note 19. (b) Principles of consolidation The consolidated financial statements incorporate the assets and liabilities of all subsidiaries of Invex Therapeutics Ltd (Company or Invex) as at 30 June 2022 and the results of all subsidiaries for the year then ended. Invex Therapeutics Ltd and its subsidiary together are referred to in these financial statements as the 'consolidated entity’. Subsidiaries are all those entities over which the consolidated entity has control. The consolidated entity controls an entity when the consolidated entity is exposed to, or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power to direct the activities of the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the consolidated entity. They are de-consolidated from the date that control ceases. Intercompany transactions, balances and unrealised gains on transactions between entities in the consolidated entity are eliminated. Unrealised losses are also eliminated unless the transaction provides evidence of the impairment of the asset transferred. Accounting policies of subsidiaries have been changed where necessary to ensure consistency with the policies adopted by the consolidated entity. The acquisition of subsidiaries is accounted for using the acquisition method of accounting. 25 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS(c) Foreign currency translation The financial statements are presented in Australian dollars, which is Invex's functional and presentation currency. Foreign currency transactions Foreign currency transactions are translated into Australian dollars using the exchange rates prevailing at the dates of the transactions. Foreign exchange gains and losses resulting from the settlement of such transactions and from the translation at financial year-end exchange rates of monetary assets and liabilities denominated in foreign currencies are recognised in profit or loss. Foreign operations The assets and liabilities of foreign operations are translated into Australian dollars using the exchange rates at the reporting date. The revenues and expenses of foreign operations are translated into Australian dollars using the average exchange rates, which approximate the rates at the dates of the transactions, for the period. All resulting foreign exchange differences are recognised in other comprehensive income through the foreign currency reserve in equity. The foreign currency reserve is recognised in profit or loss when the foreign operation or net investment is disposed of. (d) Operating segments Operating segments are presented using the 'management approach', where the information presented is on the same basis as the internal reports provided to the Chief Operating Decision Makers ('CODM'). The CODM is responsible for the allocation of resources to operating segments and assessing their performance. (e) Revenue recognition Revenue is recognised when or as the Group transfers control of goods or services to a customer at the amount at which the Group expects to be entitled. The following specific recognition criteria must also be met before revenue is recognised: Interest income Revenue is recognised as the interest accrues (using the effective interest method), which is the rate that exactly discounts estimated future cash receipts through the expected life of the financial instrument to the net carrying amount of the financial asset. (f) Loans and Receivables Loans and receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market and are stated at amortised cost using the effective interest rate method. At each reporting date, the Group assesses whether there is objective evidence that a financial instrument has been impaired. (g) Cash and Cash Equivalents Cash and short-term deposits in the Statement of Financial Position comprise cash at bank and on hand and short-term deposits. (h) Right-of-use asset A right-of-use asset is recognised at the commencement date of a lease. The right-of-use asset is measured at cost, which comprises the initial amount of the lease liability, adjusted for, as applicable, any lease payments made at or before the commencement date net of any lease incentives received, any initial direct costs incurred, and, except where included in the cost of inventories, an estimate of costs expected to be incurred for dismantling and removing the underlying asset, and restoring the site or asset. Right-of-use assets are depreciated on a straight-line basis over the unexpired period of the lease or the estimated useful life of the asset, whichever is the shorter. Where the consolidated entity expects to obtain ownership of the leased asset at the end of the lease term, the depreciation is over its estimated useful life. Right-of use assets are subject to impairment or adjusted for any remeasurement of lease liabilities. 26 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)The consolidated entity has elected not to recognise a right-of-use asset and corresponding lease liability for short-term leases with terms of 12 months or less and leases of low-value assets. Lease payments on these assets are expensed to profit or loss as incurred. (i) Lease liability A lease liability is recognised at the commencement date of a lease. The lease liability is initially recognised at the present value of the lease payments to be made over the term of the lease, discounted using the interest rate implicit in the lease or, if that rate cannot be readily determined, the consolidated entity's incremental borrowing rate. Lease payments comprise of fixed payments less any lease incentives receivable, variable lease payments that depend on an index or a rate, amounts expected to be paid under residual value guarantees, exercise price of a purchase option when the exercise of the option is reasonably certain to occur, and any anticipated termination penalties. The variable lease payments that do not depend on an index or a rate are expensed in the period in which they are incurred. Lease liabilities are measured at amortised cost using the effective interest method. The carrying amounts are remeasured if there is a change in the following: future lease payments arising from a change in an index or a rate used; residual guarantee; lease term; certainty of a purchase option and termination penalties. When a lease liability is remeasured, an adjustment is made to the corresponding right-of use asset, or to profit or loss if the carrying amount of the right-of-use asset is fully written down. (j) Goods and Services Tax (GST) Revenues, expenses and assets are recognised net of the amount of GST, except where the amount of GST incurred is not recoverable from the Tax Office. In these circumstances the GST is recognised as part of the cost of acquisition of the asset or as part of an item of the expense. Receivables and payables in the statement of financial position are shown inclusive of GST. Cash flows are presented in the statement of cash flows on a gross basis, except for the GST components of investing and financing activities, which are disclosed as operating cash flows. (k) Trade and Other Receivables Trade receivables, which generally have 30-90 day terms, are recognised and initially at fair value and subsequently measured at amortised cost using the effective interest rate method, less loss allowance. The Group applies the AASB 9 simplified approach to measure expected credit losses which uses lifetime expected loss allowance for trade receivables. Bad debts are written off when identified. (l) Trade and other Payables Trade and other payables represent liabilities for goods and services provided to the Group prior to the period end and which are unpaid. These amounts are unsecured, have 30-60 day payment terms and are measured at amortised cost. (m) Share-based payments Equity-settled and cash-settled share-based compensation benefits are provided to employees. Equity-settled transactions are awards of shares, or options over shares, that are provided to employees in exchange for the rendering of services. Cash-settled transactions are awards of cash for the exchange of services, where the amount of cash is determined by reference to the share price. The cost of equity-settled transactions are measured at fair value on grant date. Fair value is independently determined using either the Binomial or Black-Scholes option pricing model that takes into account the exercise price, the term of the option, the impact of dilution, the share price at grant date and expected price volatility of the underlying share, the expected dividend yield and the risk free interest rate for the term of the option, together with non-vesting conditions that do not determine whether the consolidated entity receives the services that entitle the employees to receive payment. No account is taken of any other vesting conditions. 27 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)The cost of equity-settled transactions are recognised as an expense with a corresponding increase in equity over the vesting period. The cumulative charge to profit or loss is calculated based on the grant date fair value of the award, the best estimate of the number of awards that are likely to vest and the expired portion of the vesting period. The amount recognised in profit or loss for the period is the cumulative amount calculated at each reporting date less amounts already recognised in previous periods. The cost of cash-settled transactions is initially, and at each reporting date until vested, determined by applying either the Binomial or Black-Scholes option pricing model, taking into consideration the terms and conditions on which the award was granted. The cumulative charge to profit or loss until settlement of the liability is calculated as follows: • during the vesting period, the liability at each reporting date is the fair value of the award at that date multiplied by the expired portion of the vesting period. • from the end of the vesting period until settlement of the award, the liability is the full fair value of the liability at the reporting date. All changes in the liability are recognised in profit or loss. The ultimate cost of cash-settled transactions is the cash paid to settle the liability. (n) Equity, reserves and dividend payments Share capital represents the fair value of shares that have been issued. Any transaction costs associated with the issuing of shares are deducted from share capital, net of any related income tax benefits. Dividend distributions payable to equity shareholders are included in other liabilities when the dividends have been approved in a General Meeting prior to the reporting date. All transactions with owners of the parent are recorded separately within equity. (o) Research and Development Research expenditure is recognised as an expense is incurred. Costs incurred on developments projects (relating to the development and testing of new or improved products) are recognised as intangible assets when it is probable that the project will, after considering its commercial and technical feasibility, be completed and generate future economic benefits and its costs can be measured reliably. The expenditure capitalized comprises all directly attributable costs, including costs of materials, services, direct labour and an appropriate proportion of overheads. Other development expenditures that do not meet these criteria are recognized as an expense as incurred. Development costs previously recognised as an expense are not recognized as an asset in a subsequent period. Capitalised development costs are recorded as intangible assets and amortised from the point at which the asset is ready for use. (p) Income Tax Tax expense recognised in profit or loss comprises the sum of deferred tax and current tax not recognised in other comprehensive income or directly in equity. Current income tax assets and/or liabilities comprise those obligations to, or claims from, the Australian Taxation Office (ATO) and other fiscal authorities relating to the current or prior reporting periods that are unpaid at the reporting date. Current tax is payable on taxable profit, which differs from profit or loss in the financial statements. Calculation of current tax is based on tax rates and tax laws that have been enacted or substantively enacted by the end of the reporting period. Deferred income taxes are calculated using the full liability method on temporary differences between the carrying amounts of assets and liabilities and their tax bases. However, deferred tax is not provided on the initial recognition of goodwill or on the initial recognition of an asset or liability unless the related transaction is a business combination or affects tax or accounting profit. Deferred tax on temporary differences associated with investments in subsidiaries and joint ventures is not provided if reversal of these temporary differences can be controlled by the Group and it is probable that reversal will not occur in the foreseeable future. 28 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)Deferred tax assets and liabilities are calculated, without discounting, at tax rates that are expected to apply to their respective period of realisation, provided they are enacted or substantively enacted by the end of the reporting period. Deferred tax assets are recognised to the extent that it is probable that they will be able to be utilised against future taxable income, based on the Group’s forecast of future operating results which is adjusted for significant non-taxable income and expenses and specific limits to the use of any unused tax loss or credit. Deferred tax liabilities are always provided for in full. Deferred tax assets and liabilities are offset only when the Group has a right and intention to set off current tax assets and liabilities from the same taxation authority. Changes in deferred tax assets or liabilities are recognised as a component of tax income or expense in profit or loss, except where they relate to items that are recognised in other comprehensive income (such as the revaluation of land) or directly in equity, in which case the related deferred tax is also recognised in other comprehensive income or equity, respectively. (q) Impairment of assets Non-financial assets At the end of each reporting period, non-financial assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. An impairment loss is recognised for the amount by which the asset’s carrying amount exceeds its recoverable amount. Recoverable amount is the higher of an asset’s fair value less costs of disposal and value-in-use. The value- in-use is the present value of the estimated future cash flows relating to the asset using a pre-tax discount rate specific to the asset or cash-generating unit to which the asset belongs. Assets that do not have independent cash flows are grouped together to form a cash-generating unit. Financial assets At the end of each reporting period, the Group assesses whether there is objective evidence that a financial asset has been impaired. For financial assets measured at fair value, gains or losses will be recorded in profit or loss, or through Other Comprehensive Income (FVTOCI) if the Group has made an irrevocable election at the time of initial recognition to account for equity instruments through OCI. (r) Critical Accounting Estimates and Judgments Required The directors evaluate estimates and judgments incorporated into the financial report based on historical knowledge and best available current information. Estimates assume a reasonable expectation of future events and are based on current trends and economic data, obtained both externally and within the Group. Coronavirus (COVID-19) pandemic Judgement has been exercised in considering the impacts that the Coronavirus (COVID-19) pandemic has had, or may have, on the consolidated entity based on known information. This consideration extends to the nature of the products and services offered, customers, supply chain, staffing and geographic regions in which the consolidated entity operates. Other than as addressed in specific notes, there does not currently appear to be either any significant impact upon the financial statements or any significant uncertainties with respect to events or conditions which may impact the consolidated entity unfavourably as at the reporting date or subsequently as a result of the Coronavirus (COVID-19) pandemic. Research and development expenditure Distinguishing the research and development phases of a new customized project and determining whether the recognition requirements for the capitalization of development costs are met requires judgement. The Group has expensed all costs relating to research and development expenditure to date on the basis that the capitalisation requirements have not been met. The Group’s consideration of whether its internal projects to develop drugs are in a research phase or development phase involves significant judgement. 29 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)The Group considers a project to be in a development phase when the following can be demonstrated: • The technical feasibility of completing the intangible asset so that it will be available for use or sale; • There is intention to complete the project; • The existence of a market to be able to sell output resulting from the project; • How the intangible asset will generate probable future economic benefits; • There is adequate technical, financial and other resources available to complete the development and to use or sell the intangible asset; and • Expenditure attributable to the project can be reliably measured. Share-based payment transactions The Group measures the cost of equity-settled transactions by reference to the fair value of the equity instruments at the date at which they are granted. The fair value is determined using a Black-Scholes model. 30 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)4. OTHER INCOME R&D Tax rebate Interest income 2022 $ 182,251 79,881 262,132 2021 $ — 158,785 158,785 5. LOSS FOR THE YEAR The loss for the year before income tax includes the following specific expenses: (a) Research and development expenses Manufacturing expenses Reformulation Phase II Clinical Trial Phase III Clinical Trial Employee costs Regulatory advice Consultants Scientific Advisory Board/Committees CSO - Executive director fees Patent expenses Total (b) Administration expenses Accounting and company secretarial fees ASX, ASIC and bank fees Executive Director’s fees Non-executive Director’s fees Legal fees Rent and office expenses Audit, corporate advice and tax fees Travel and entertainment Insurance Investor relations and PR expenses Share registry and shareholder meetings Other general expenses Unrealised fx gain Website and IT expenses Total 2022 $ 2021 $ 326,498 — — 762,449 509,892 189,548 714,836 1,094 315,373 142,907 — 106,828 15,779 106,073 395,097 — 247,908 2,652 150,000 114,886 2,962,596 1,139,222 131,759 69,597 138,750 160,000 109,240 20,980 68,100 30,891 92,004 51,116 20,122 13,703 (26,408) 20,432 900,286 131,703 89,462 93,750 128,750 25,896 31,626 63,025 (11,430) 68,575 55,152 30,785 22,202 — 11,256 740,752 31 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)6. INCOME TAX (a) The components of tax expense comprise: Current tax Deferred tax expense Total income tax expense from continuing operations Deferred income tax expense included in income tax expense comprises: Decrease/(increase) in deferred tax assets Decrease/(increase) in deferred tax liabilities (b) The prima facie tax on profit from ordinary activities before income tax is reconciliation of income tax expense to prima facie tax payable: 2022 $ 2021 $ — — — — — — — — — — Loss before income tax (3,953,140) (2,283,911) Prima facie tax benefit on loss from ordinary activities before income tax at 30% (2021: 30%) (1,185,942) (685,173) Tax effect of: – share-based payments – intellectual property costs – entertainment – other – tax differential rate Tax losses and temporary differences not recognised Income tax expense/(benefit) The applicable weighted average effective tax rate are as follows: (c) Amounts recognised directly in equity Aggregate current and deferred tax arising in the reporting period and not recognised in net loss or other comprehensive income but directly debited or credited to equity. Current tax Net deferred tax 32 105,717 42,872 587 — 232,932 804,374 — 0% 168,187 34,446 422 127 77,448 403,894 — 0% — 166,109 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)(d) Deferred tax assets Patents Accruals Business related costs Australian tax losses Unrealised fx losses Foreign tax losses Capital raising costs in equity 7. CASH AND CASH EQUIVALENTS Cash at bank and on hand 8. TRADE AND OTHER PAYABLES Trade payables Accruals and other payables 2022 $ 34,576 7,500 28,112 1,748,686 (7,922) 207,379 264,422 2,282,753 2021 $ 29,801 7,200 37,413 1,175,857 4,734 211,221 408,202 1,874,427 2022 $ 29,339,382 29,339,382 2021 $ 32,716,091 32,716,091 2022 $ 138,778 865,436 1,004,214 2021 $ 11,333 647,281 658,614 Trade payables are non-interest bearing and are normally settled on 30-day terms. 9. CONTRIBUTED EQUITY 2022 $ 2022 Number of shares 2021 $ 2021 Number of shares Ordinary shares on issue – fully paid 36,413,432 75,153,848 36,413,432 75,153,848 36,413,432 75,153,848 36,413,432 75,153,848 Holders of ordinary shares are entitled to receive dividends as declared from time to time and are entitled to one vote per share at shareholders meetings. In the event of winding up of the Company ordinary shareholders rank after creditors and are fully entitled to any proceeds of liquidation in proportion to the number and amount paid on the shares held. Movement in fully paid ordinary shares on issue Balance at beginning of financial period Placement (May 20 and July 20) Cost of capital raising 2022 $ 2022 Number of shares 2021 $ 2021 Number of shares 36,413,432 75,153,848 27,017,127 67,500,001 — — — — 9,949,975 7,653,847 (553,670) — Balance at end of financial year 36,413,432 75,153,848 36,413,432 75,153,848 33 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)10. RESERVES Share-based payment reserve Foreign currency translation reserve Nature and Purpose of Reserve 2022 $ 2021 $ 1,898,630 1,546,240 (1,727) (4,684) 1,896,903 1,541,556 The share-based payment reserve records the value of options, performance rights and performance shares issued to the Group’s directors, employees, and third parties. The value of the amount disclosed during the period reflects the value of options, performance rights and performance shares issued by the Group. The Foreign currency translation reserve records exchange differences arising on translation of foreign controlled entities. Options outstanding at 30 June 2022 The following options over ordinary shares of the Company were granted at reporting date: Grant Date Expiry Date Exercise Price Balance at start of year Granted during the year Exercised during the year Forfeited during the year Balance at year end Vested and exercisable at year end 22 Nov 2019 22 Nov 2023 $0.60 2,200,000 21 Jan 2020 21 Jan 2023 $1.00 750,000 9 April 2020 9 April 2023 $0.60 60,000 20 Oct 2020 20 Oct 2023 $1.30 400,000 18 Nov 2020 18 Nov 2023 $1.30 800,000 8 April 2021 8 April 2024 $1.10 400,000 4,610,000 — — — — — — — — — — — — — — Reconciliation of movement in Share-based payment reserve: Opening Balance - 1 July 2021 — 2,200,000 2,200,000 — 750,000 750,000 — 60,000 60,000 — 400,000 200,000 — 800,000 400,000 — 400,000 200,000 — 4,610,000 3,810,000 Number of Options Value $ 1,546,240 Share-based payment expense in respect to Director options on issue at 30 June 2022 2,200,000 72,032 Share-based payment expense in respect to employee options on issue at 30 June 2022 Share-based payment expense in respect to employee options on issue at 30 June 2022 Share-based payment expense in respect to Director options on issue at 30 June 2022 Share-based payment expense in respect to Director options on issue at 30 June 2022 Closing Balance – 30 June 2022 60,000 6,214 400,000 64,681 800,000 125,114 400,000 84,169 4,610,000 1,898,630 34 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)11. LOSS PER SHARE Basic and Diluted (Loss) per Share – cents Total basic and diluted loss per share – cents 2022 $ (5.26) 2021 $ (3.04) Basic and diluted loss per share is calculated by dividing the loss for the year attributable to ordinary equity holders of the parent by the weighted average number of ordinary shares outstanding during the year. The following table reflects the loss and share data used in the basic and diluted loss per share: Net loss attributable to members of the Group (3,953,140) (2,283,911) Earnings used in calculating basic and diluted earnings per share from continuing operations (3,953,140) (2,283,911) 2022 $ 2021 $ 2022 Number of shares 2021 Number of shares Weighted average number of Ordinary Shares used in calculating basic and diluted earnings per share 75,153,848 75,132,821 Dilutive Potential Ordinary Shares As at balance date, there were no dilutive options on issue. Conversions, Calls, Subscriptions or Issues after 30 June 2022 Subsequent to year end there have not been any conversions, calls, subscriptions or issues of securities. 12. ACCUMULATED LOSSES Accumulated losses at the beginning of the financial period Net loss attributable to members of the Group Accumulated losses at the end of the financial year 2022 $ 2021 $ (5,876,312) (3,953,140) (3,592,401) (2,283,911) (9,829,452) (5,876,312) 35 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)13. RECONCILIATION OF NET CASH FLOWS OPERATING ACTIVITIES TO OPERATING (LOSS) AFTER TAX 2022 $ 2021 $ (3,953,140) (2,283,911) 352,390 2,957 562,723 1,591 (124,517) 345,601 95,682 (54,330) (3,376,709) (1,678,245) Loss (after income tax) for the year Non-cash items included in profit or loss: Share-based payment expenses Unrealised fx reserve movements Net changes in working capital: Decrease/(increase) in trade and other receivables Increase/(decrease) in trade and other payables Net cash used in operating activities Non-cash investing and financing activities disclosed in other notes are: Share-based payment expense (refer Note 17). FX reserve movements (refer Note 10). 14. FINANCIAL RISK MANAGEMENT The Group’s principal financial instruments comprise cash, short-term deposits and trade payables. The Group does not have any derivative instruments at 30 June 2022 and does not speculate in any financial instruments. Financial Risks The activities of the Group expose it primarily to the financial risks of interest rate risk, liquidity risk, foreign exchange risk and credit risk. The Board of Directors is responsible for monitoring and managing the financial risks of the Group. The Company Secretary/CFO monitors these risks by the review and analysis of monthly management accounts and other financial data. Interest Rate Risk The Group’s main interest rate risk arises from cash held on deposit by Australian Financial Institutions. Cash held in term deposits is subject to prevailing variable interest rates and expose the Group to cash flow interest rate risk. The following table summarises interest rate risk for the Group. 2022 Interest-bearing financial instruments Cash and cash equivalents Fixed Interest Rate Maturing Floating Interest Rate $ 1 Year or Less $ 1 to 5 Years $ Non- Interest Bearing $ Total $ 29,339,382 29,339,382 — — — — — 29, 339,382 — 29,339,382 36 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)2021 Interest-bearing financial instruments Cash and cash equivalents Fixed Interest Rate Maturing Floating Interest Rate $ 1 Year or Less $ 1 to 5 Years $ Non- Interest Bearing $ Total $ 32,716,091 32,716,091 — — — — — 32,716,091 — 32,716,091 The Group does not rely on the generation of interest on cash at bank to provide working capital and does not consider the exposure to be material to the Group and have therefore not undertaken any further analysis of exposure. Liquidity Risk Liquidity risk is the risk that the Group will not be able to meet its financial obligations as they fall due. The Board of Directors manage liquidity risk by continually monitoring cash reserves and cashflow forecasts to ensure that financial commitments can be met as and when they fall due. The Group’s objective is to maintain a balance between continuity of funding and flexibility through the use of equity funding. The following table details the expected contractual maturity for its non-derivative financial liabilities. 2022 Financial liabilities due Trade and other payables 2021 Financial liabilities due Trade and other payables Credit Risk Exposure Total $ 1 year or less $ 1 – 5 years $ 5+ years $ 138,778 138,778 138,778 138,778 — — — — Total $ 11,333 11,333 1 year or less $ 11,333 11,333 1 – 5 years $ 5+ years $ — — — — Credit risk is the risk of financial loss to the Group if a customer or counterparty to a financial instrument fails to meet its contractual obligations and arises principally from the Group’s cash at bank. The carrying amount of the financial assets on the Statement of Financial Position represents the maximum credit exposure. All cash and cash equivalents are held with large reputable financial institutions within Australia and therefore credit risk is considered minimal. Cash and cash equivalents: AA rated 2022 $ 2021 $ 29,339,382 32,716,091 37 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)Foreign currency risk The consolidated entity undertakes certain transactions denominated in foreign currency and is exposed to foreign currency risk through foreign exchange rate fluctuations. Foreign exchange risk arises from future commercial transactions and recognised financial assets and financial liabilities denominated in a currency that is not the entity’s functional currency. The risk is measured using sensitivity analysis and cash flow forecasting. 15. RELATED PARTY TRANSACTIONS Key Management Personnel There were no key management personnel, other than the directors and the CFO/Company Secretary, during the year ended 30 June 2022. The names of each person holding the position of director of the Company during the financial year are set out below: • Dr Jason Loveridge • Prof. Alexandra Sinclair • Dr Thomas Duthy • Dr Megan Baldwin • Mr David McAuliffe • Ms Narelle Warren Transactions with key management personnel (i) Total key management personnel remuneration is as follows: Short Term Benefits Other non-cash Benefits Post-Employment Benefits Share-based payments 2022 $ 2021 $ 966,468 590,873 — 467 — 1,626 281,315 508,922 1,248,250 1,101,421 (ii) Nil loans were payable to or receivable from KMPs during or at the end of the financial year. Unless otherwise stated, none of the transactions incorporate special terms and conditions and no guarantees were given or received. 16. INTERESTS IN SUBSIDIARY The consolidated financial statements incorporate the assets, liabilities and results of the following wholly- owned subsidiary in accordance with the accounting policy described in note 3: Name Principal place of business / Country of incorporation Invex Therapeutics Ltd United Kingdom Ownership interest 2022 % 100 2021 % 100 38 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)17. SHARE-BASED PAYMENTS Share-based payments made during the year ended 30 June 2022 are summarised below. Recognised Share-based payment expense Options granted to Directors as incentive Options granted to Advisers as incentive Options granted to Employees as incentive 2022 $ 2021 $ 281,315 508,922 — (32,228) 71,075 86,029 352,390 562,723 Options granted to Directors and Employees for services The Group’s current Employee Share Option Plan (ESIP) was approved by Shareholders on 25 November 2021. The previous Employee Share Option Plan (ESOP) was approved by the Board of Directors on 20 May 2019 (Incentive Plans). The Incentive Plans are designed to provide medium and long term incentives for all employees (including Non-executive and Executive Directors) and to attract and retain experienced Employees, Board Members and Executive Officers and provide motivation to make the Group more successful. Under the previous ESOP, participants have been granted options which only vest if certain milestones are met. Participation in the plan is at the board’s discretion and no individual has a contractual right to participate in the plan or to receive any guaranteed benefit. Any option may only be exercised after the option has vested and other conditions imposed by the board have been satisfied. Options are granted under the ESOP for no consideration. Options granted under the ESOP carry no dividend or voting rights. When exercisable, shares allotted pursuant to the exercise of options will be allotted following receipt of relevant documentation and payments will rank equally with all other shares. As options granted to employees and directors are considered to represent the value of the services received over the vesting period of the options, the assessed value of the options are recognised and expensed over the vesting period. Options vesting during the year of issue are fully expensed under the accounting standards. There were no new incentive securities granted during the financial year. The total Directors and Employee Options expense for the period is outlined below. Valuation Tranche Date Expiry Date Exercise Price Balance at start of year Granted during the year Vested at year end 22 Nov 2019 22 Nov 2023 $0.60 2,200,000 — 2,200,000 9 April 2020 9 April 2023 $0.60 60,000 20 Oct 2020 20 Oct 2023 18 Nov 2020 18 Nov 2023 8 April 2021 8 April 2024 $1.30 $1.30 $1.10 400,000 800,000 400,000 — — — — 60,000 200,000 400,000 200,000 1 3 4 5 6 Total Total Share-based payment expense for the year $ 72,032 6,214 64,681 125,114 84,169 3,860,000 — 3,060,000 352,210 39 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)Appropriate values for the options using the Black Scholes Model applying the following inputs. Tranche Exercise price Expected volatility Expiry date (years) Expected dividends Risk free rate Value per option 1 3 $0.60 $0.60 75% 4.00 Nil 0.77% $0.42 75% 3.00 Nil 0.77% $0.55 4 $1.30 80% 3.00 Nil 0.77% $0.35 5 $1.30 80% 3.00 Nil 0.87% $0.32 6 $1.10 80% 3.00 Nil 0.77% $0.33 The vesting conditions attached to the Tranche 1, 3, 4, 5 and 6 Director and Employee Options are as follows: • 50% of the Options will vest and become exercisable upon completion of 12 months continuous service from date of issue; and • 50% of the Options vest and become exercisable upon completion of 24 months continuous service from date of issue. The weighted average remaining contractual life of options outstanding at the end of the year was 1.04 years. 18. MATTERS SUBSEQUENT TO END OF FINANCIAL YEAR On 1 July 2022, Carol Parish was appointed Chief Operating Officer (COO) at the Group. Until 30 June 2022, Carol held the role as Head of Clinical Operations. Carol has been a pharmaceutical professional for over 33 years within the Pharmaceutical/Biotech industry, where she has been accountable for all Phases of drug development in multiple therapy areas. Prior to joining Invex, Carol was the Global Clinical Operations Lead at Intercept Pharmaceuticals (NASDAQ: ICPT) and has held various senior clinical positions at Stiefel Laboratories (acquired by GlaxoSmithKline in 2009) including Senior Director, Global Clinical Development for a new drug product, including collaborating with GSK Japan and China.  Additionally, Carol spent over 20 years at Merck & Co (NYSE:MRK) and Johnson & Johnson (NYSE:JNJ). Other than as disclosed above, no matters or events have arisen since the end of the financial period which significantly affected or may significantly affect the operations of the company, the results of those operations or the state of affairs of the company in subsequent financial periods. 40 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)19. PARENT ENTITY INFORMATION Set out below is the supplementary information about the parent entity. Statement of profit or loss and other comprehensive income Loss after income tax Total comprehensive income Statement of financial position Total current assets Total non-current assets Total current liabilities Total liabilities Equity Issued capital Reserves Accumulated losses Total equity 20. AUDITOR’S REMUNERATION Amounts paid or payable to BDO for: Audit services – an audit or review of the financial report of the entity Total audit services Corporate advisory services Taxation services Total other services Parent 2022 $ 2021 $ (4,692,091) (1,579,841) (4,692,091) (1,579,841) Parent 2022 $ 2021 $ 29,225,668 32,667,047 — 901,054 642,157 655,521 642,157 655,521 36,413,432 36,413,432 1,898,630 1,541,556 (9,728,551) (5,036,460) 28,583,511 32,918,528 2022 $ 2021 $ 37,376 37,376 2,000 5,658 7,658 35,126 35,126 — 2,500 2,500 41 ANNUAL REPORT 2022NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)21. DIVIDENDS There are no dividends paid or payable at 30 June 2022. 22. COMMITMENTS There are no other commitments which require disclosure as at 30 June 2022 (30 June 2021: nil). 23. SEGMENT REPORTING The Group has identified its operating segments based on the internal reports that are reviewed and used by the Board of Directors in assessing performance and determining the allocation of resources. The Group is managed primarily on the basis of its research and development activities. Operating segments are therefore determined on the same basis. Reportable segments disclosed are based on aggregating operating segments where the segments are considered to have similar economic characteristics. The Group operated in one segment which is research and development activities within Australia. The Company is domiciled in Australia. 24. CONTINGENT LIABILITIES AND CONTINGENT ASSETS The Directors are not aware of any contingent liabilities or contingent assets which require disclosure as at 30 June 2022 (30 June 2021 : nil). 42 INVEX THERAPEUTICS LTD. NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS (CONT.)DIRECTORS’ DECLARATION In the Directors’ opinion: (a) the financial statements and notes are in accordance with the Corporations Act 2001, and: (i) complying with Accounting Standards, the Corporations Regulations 2001 and other mandatory professional reporting requirements; and (ii) give a true and fair view of the financial position as at 30 June 2022 and of the performance for the year ended on that date of the Group. (iii) are in accordance with International Financial Reporting Standards issued by the International Accounting Standards Board, as stated in note 1 to the financial statements; and (b) In the Directors’ opinion, there are reasonable grounds to believe that the Group will be able to pay its debts as and when they become due and payable; and (c) The Directors have been given the declarations by the Executive Director as required by section 295A, of the Corporations Act 2001. This declaration is made in accordance with a resolution of the Board of Directors and is signed for and on behalf of the directors by; David McAuliffe Non-executive Director Perth, Western Australia, 19 August 2022 43 ANNUAL REPORT 2022INDEPENDENT AUDITOR’S REPORT Tel: +61 8 6382 4600 Fax: +61 8 6382 4601 www.bdo.com.au Level 9, Mia Yellagonga Tower 2 5 Spring Street Perth WA 6000 PO Box 700 West Perth WA 6872 Australia INDEPENDENT AUDITOR’S REPORT To the members of Invex Therapeutics Ltd Report on the Audit of the Financial Report Opinion We have audited the financial report of Invex Therapeutics Ltd (the Company) and its subsidiary (the Group), which comprises the consolidated statement of financial position as at 30 June 2022, the consolidated statement of profit or loss and other comprehensive income, the consolidated statement of changes in equity and the consolidated statement of cash flows for the year then ended, and notes to the financial report, including a summary of significant accounting policies and the directors’ declaration. In our opinion the accompanying financial report of the Group, is in accordance with the Corporations Act 2001, including: (i) Giving a true and fair view of the Group’s financial position as at 30 June 2022 and of its financial performance for the year ended on that date; and (ii) Complying with Australian Accounting Standards and the Corporations Regulations 2001. Basis for opinion We conducted our audit in accordance with Australian Auditing Standards. Our responsibilities under those standards are further described in the Auditor’s responsibilities for the audit of the Financial Report section of our report. We are independent of the Group in accordance with the Corporations Act 2001 and the ethical requirements of the Accounting Professional and Ethical Standards Board’s APES 110 Code of Ethics for Professional Accountants (including Independence Standards) (the Code) that are relevant to our audit of the financial report in Australia. We have also fulfilled our other ethical responsibilities in accordance with the Code. We confirm that the independence declaration required by the Corporations Act 2001, which has been given to the directors of the Company, would be in the same terms if given to the directors as at the time of this auditor’s report. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. BDO Audit (WA) Pty Ltd ABN 79 112 284 787 is a member of a national association of independent entities which are all members of BDO Australia Ltd ABN 77 050 110 275, an Australian company limited by guarantee. BDO Audit (WA) Pty Ltd and BDO Australia Ltd are members of BDO International Ltd, a UK company limited by guarantee, and form part of the international BDO network of independent member firms. Liability limited by a scheme approved under Professional Standards Legislation 44 INVEX THERAPEUTICS LTD.INDEPENDENT AUDITOR’S REPORT (CONT.) Key audit matters Key audit matters are those matters that, in our professional judgement, were of most significance in our audit of the financial report of the current period. These matters were addressed in the context of our audit of the financial report as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters. We have not identified any key audit matters for Invex Therapeutics Ltd. Other information The directors are responsible for the other information. The other information comprises the information in the Group’s annual report for the year ended 30 June 2022, but does not include the financial report and the auditor’s report thereon. Our opinion on the financial report does not cover the other information and we do not express any form of assurance conclusion thereon. In connection with our audit of the financial report, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial report or our knowledge obtained in the audit or otherwise appears to be materially misstated. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact. We have nothing to report in this regard. Responsibilities of the directors for the Financial Report The directors of the Company are responsible for the preparation of the financial report that gives a true and fair view in accordance with Australian Accounting Standards and the Corporations Act 2001 and for such internal control as the directors determine is necessary to enable the preparation of the financial report that gives a true and fair view and is free from material misstatement, whether due to fraud or error. In preparing the financial report, the directors are responsible for assessing the ability of the group to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the directors either intend to liquidate the Group or to cease operations, or has no realistic alternative but to do so. Auditor’s responsibilities for the audit of the Financial Report Our objectives are to obtain reasonable assurance about whether the financial report as a whole is free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with the Australian Auditing Standards will always detect a material misstatement when it exists. 45 ANNUAL REPORT 2022INDEPENDENT AUDITOR’S REPORT (CONT.) Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of this financial report. A further description of our responsibilities for the audit of the financial report is located at the Auditing and Assurance Standards Board website (http://www.auasb.gov.au/Home.aspx) at: https://www.auasb.gov.au/admin/file/content102/c3/ar1_2020.pdf This description forms part of our auditor’s report. Report on the Remuneration Report Opinion on the Remuneration Report We have audited the Remuneration Report included in pages 12 to 19 of the directors’ report for the year ended 30 June 2022. In our opinion, the Remuneration Report of Invex Therapeutics Ltd, for the year ended 30 June 2022, complies with section 300A of the Corporations Act 2001. Responsibilities The directors of the Company are responsible for the preparation and presentation of the Remuneration Report in accordance with section 300A of the Corporations Act 2001. Our responsibility is to express an opinion on the Remuneration Report, based on our audit conducted in accordance with Australian Auditing Standards. BDO Audit (WA) Pty Ltd Jarrad Prue Director Perth, 19 August 2022 46 INVEX THERAPEUTICS LTD.CORPORATE GOVERNANCE STATEMENT In fulfilling its obligations and responsibilities to its various stakeholders, the Board is a strong advocate of corporate governance. This statement outlines the principal corporate governance procedures of Invex Therapeutics Ltd (Group). The Board of Directors (Board) supports a system of corporate governance to ensure that the management of Invex Therapeutics Ltd is conducted to maximise shareholder wealth in a proper and ethical manner. ASX CORPORATE GOVERNANCE COUNCIL RECOMMENDATIONS The Board has adopted corporate governance policies and practices consistent with the ASX Corporate Governance Council's Principles of Good Corporate Governance and Best Practice Recommendations ("ASX Principles and Recommendations 4th Edition") where considered appropriate for Invex Therapeutics Ltd size and nature. Such policies include, but are not limited to the Board Charter, Board Committee Charters, Code of Conduct, Trading in Securities, Continuous Disclosure, Shareholder Communication and Risk Management Policies. Further details in respect to the Group’s corporate governance practises and copies of the Group’s corporate governance policies and the 2022 Corporate Governance Statement, approved by the Board and applicable as at 30 June 2022 are available of the Group’s website: https://invextherapeutics.com/corporate-governance/ 47 ANNUAL REPORT 2022ASX ADDITIONAL INFORMATION Additional information required by the ASX Limited Listing Rules not disclosed elsewhere in this Annual Report is set out below. 1. SHAREHOLDINGS The issued capital of the Company as at 1 August 2022 is 75,153,848 ordinary fully paid shares. All issued ordinary fully paid shares carry one vote per share. Ordinary Shares Shares Range 1-1,000 1,001-5,000 5,001-10,000 10,001-100,000 100,001 and above Total Unmarketable parcels Holders 233 483 240 438 Units 143,116 1,331,649 1,921,496 15,102,038 91 56,655,549 % 0.19 1.77 2.56 20.09 75.39 1,485 75,153,848 100.00 There were 178 holders of less than a marketable parcel of ordinary shares representing a total of 88,383 shares. 2. TOP 20 SHAREHOLDERS AS AT 1 AUGUST 2022 Name 1 TATTARANG 2 TISIA NOMINEES PTY LTD 3 DR JASON LOVERIDGE 4 MR DAVID JERIMIAH MCAULIFFE 5 JK NOMINEES PTY LTD 6 ANTHONY GRIST 7 ALEXANDRA JEAN SINCLAIR 8 MRS KATHRYN SALKILLD 9 THE UNIVERSITY OF BIRMINGHAM 10 CITICORP NOMINEES PTY LIMITED Number of shares 8,846,154 4,000,000 3,374,462 3,350,001 3,000,000 2,749,000 2,500,000 2,293,000 2,000,000 1,954,956 11 BANNABY INVESTMENTS PTY LIMITED 1,625,000 12 SUNSET CAPITAL MANAGEMENT PTY LTD 1,448,175 13 CITYSCAPE ASSET PTY LTD 14 CABLETIME PTY LTD 15 SANDHURST TRUSTEES LTD 16 NETWEALTH INVESTMENTS LIMITED 17 PETER KYROS PTY LTD 18 PALLA NOMINEES PTY LTD

19 HSBC CUSTODY NOMINEES (AUSTRALIA) LIMITED 20 MAGAURITE PTY LTD TOP 20 TOTAL TOTAL REMAINING HOLDERS BALANCE TOTAL 48 % 11.77 5.32 4.49 4.46 3.99 3.66 3.33 3.05 2.66 2.60 2.16 1.93 1.66 1.49 1.44 0.88 0.78 0.77 0.77 0.75 1,250,000 1,120,000 1,081,924 658,751 588,616 580,000 578,184 560,000 43,558,223 31,595,625 57.96 42.04 75,153,848 100.00 INVEX THERAPEUTICS LTD.ASX ADDITIONAL INFORMATION (CONT.) 3. UNQUOTED SECURITIES The unlisted options over shares in the Company as at 1 August 2022 are as follows: Holder DR JASON LOVERIDGE ALEXANDRA JEAN SINCLAIR CIPA INVESTMENTS PTY LTD WACC PTY LTD DR MEGAN BALDWIN CAROL PARISH PHILUCHNA PTY LTD DAVID JERIMIAH MCAULIFFE EMMA HILTON Total 4. VOTING RIGHTS See note 12 of the financial statements. Number of options held % of issued capital held 800,000 800,000 800,000 750,000 400,000 400,000 400,000 200,000 60,000 17.35 17.35 17.35 16.27 8.68 8.68 8.68 4.34 1.30 4,610,000 100.00 5. SUBSTANTIAL SHAREHOLDERS AS AT 1 AUGUST 2022 Holder TATTARANG TISIA NOMINEES PTY LTD Number of shares held % of issued capital held 8,846,154 4,000,000 11.77 5.32 6. RESTRICTED SECURITIES SUBJECT TO ESCROW PERIOD There are no restricted securities. 7. ON-MARKET BUYBACK There is currently no on-market buyback program for any of Invex’s listed securities. 8. COMPANY CASH AND ASSETS In accordance with Listing Rule 4.10.19, the Company confirms that it has been using the cash and assets it had acquired at the time of admission and for the year ended 30 June 2022 in a way that is consistent with its business objective and strategy. 49 ANNUAL REPORT 2022This page has been left blank intentionally. 50 INVEX THERAPEUTICS LTD.CORPORATE DIRECTORY This financial report includes the consolidated financial statements and notes of the Group consisting of Invex Therapeutics Ltd and its controlled entity (Invex Therapeutics UK). The Group’s functional and presentation currency is Australian Dollars ($). A description of the Group’s operations and principal activity is included in the review of operations and activities in the Directors’ report on pages 8 to 19. The Directors’ Report is not part of the Consolidated Financial Report. Directors: Dr Jason Loveridge Professor Alexandra Sinclair Dr Thomas Duthy Dr Megan Baldwin Mr David McAuliffe Company Secretary: Ms Narelle Warren Registered Office & Principal Place of Business: Level 2, 38 Rowland St Subiaco WA 6008 Tel: +61 8 6382 0137 Website: www.invextherapeutics.com Auditors: BDO Level 9 Mia Yellagonga Tower 2 5 Spring Street Perth WA 6000 Bankers: Westpac Banking Corporation Level 4 Tower 2 Brookfield Place 123 St Georges Terrace Perth WA 6000 Solicitors: Steinepreis Paganin Level 4, The Read Buildings 16 Milligan St Perth WA 6000 Share Registry: Automic Registry Services Telephone: 1300 288 664 International: +61 2 9698 5414 Website: www.automicgroup.com.au ASX code: IXC ideate Co. 51 ANNUAL REPORT 2022

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