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Invex Therapeutics Ltd

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FY2023 Annual Report · Invex Therapeutics Ltd
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Annual Report
2022-23

Directors’ Report  .................................................... 6

Auditor’s Independence Declaration  ..............  18

Consolidated Statement  
of Profit or Loss and  
Other Comprehensive Income ..........................  19

Consolidated Statement 
of Financial Position  ...........................................  20

Consolidated Statement 
of Changes in Equity  ...........................................  21

Consolidated Statement  
of Cash Flows  ........................................................ 22

Notes to the Financial Statements  .................. 23

Directors’ Declaration  .........................................  41

Independent Auditor’s Report  ........................  42

Corporate Governance Statement  .................  46

ASX Additional Information  .............................. 47

Corporate Directory  ............................................... iii

Contents

CORPORATE 
HIGHLIGHTS
PAGE 1

CHAIRMAN’S 
LETTER
PAGE 2

iiii

INVEX THERAPEUTICS LTD.

INVEX THERAPEUTICS LTD.2023 Corporate Highlights

$22.5m

$1.1m

15.3

Cash

$6.9m

Operating Cash Burn

$7.7m

Net Loss after Tax

Annual Corporate 
overhead
(excluding R&D and 
share-based compensation)

Impact factor of the 
Brain Journal where Invex 
Phase II ‘Pressure’ Trial 
published 

$0.46m

Cash received from 
Invex’s wholly owned UK 
subsidiary from the UK 
government for eligible 
R&D expenditures

$7.4m

Investment into R&D

18%

Directors and 
Management share 
ownership

1

ANNUAL REPORT 2023Chairman’s letter

Dear Shareholders,

On behalf of the Board of Invex 
Therapeutics Ltd (Invex, the 
Company) and its controlled 
entity (Group), we hereby present 
the Invex Annual Report to 
shareholders for the year ended 
30 June 2023 (FY23). During the 
year, we focused our efforts and 
expenditure on our Phase III trial for 
Idiopathic Intracranial Hypertension 
(IIH) called IIH EVOLVE.

By way of background, IIH is a 
chronic condition that develops 
predominately in obese women 
of child bearing age, where 
intracranial pressure (ICP) in 
the brain elevates significantly, 
resulting in disabling daily 
headaches and in some cases 
permanent vision loss. There are 
currently no European Medicines 
Agency (EMA) and US Food 
and Drug Administration (FDA) 
treatments approved for IIH. 
Hence, there is an urgent need to 
develop new drug treatments for 
these patients, who suffer from 
significant quality of life effects 
with IIH patients often requiring 
multiple hospital admissions, 
representing a large cost to the 
healthcare system. 

IIH EVOLVE is a placebo-
controlled, double-blind trial that 
in FY23 commenced randomising 
240 patients with newly 
diagnosed IIH to determine the 
efficacy and safety of Presendin™ 
(sustained release Exenatide) 
versus placebo, administered 
once weekly over 24 weeks. The 
primary endpoint of the trial is the 
change in intracranial pressure 
from baseline with key secondary 
endpoints related to vision and 
headache outcome measures. 

Invex intends to open up to 40 
clinical sites globally. Information 
on the trial is available at 
clinicaltrials.gov under Identifier 
NCT05347147.

FY23 started with a great deal 
of enthusiasm as we received a 
significant number of regulatory 
approvals to commence our 
IIH EVOLVE Phase III clinical 
trial in the United States, 
United Kingdom, Australia 
and New Zealand during the 
first half and then recruited 
our first patient in November 
2022 in Adelaide, Australia. The 
second half reflected the strong 
regulatory success once more 
in France, Germany and Israel. 
In addition, we qualified almost 
all of the 40 sites we anticipated 
activating for patient recruitment 
during the period. Unfortunately, 
the time difference between 
receiving these approvals 
and qualifying these sites to 
then activate them for patient 
recruitment and recruitment itself 
has proved much slower than 
anticipated.

On 28 June 2023, the Group 
provided an update to the market 
following a comprehensive review 
of the reasons behind the slower 
than expected patient enrolment 
into the IIH EVOLVE Phase III 
clinical trial. As of 26 June 2023, 
the Company had enrolled 
13 patients into the IIH EVOLVE 
trial with a total of 12 sites 
activated out of the target sites of 
40 globally, behind expectations. 
The Company noted a high 
number of patients who had been 
screened (n=25) had failed to be 
enrolled and over 50 additional 
IIH patients had been pre-
screened and not progressed 
to screening. 

2

The main factors negatively 
impacting enrolment were a 
Perimetric Mean Deviation (PMD) 
score outside of the inclusion 
criteria in approximately 60% of 
IIH patients screened and the 
majority of pre-screen patients 
having a diagnostic lumbar 
puncture to assess their ICP 
falling outside of the 4 week 
period immediately prior to 
formal screening. 

The Board, having consulted 
extensively with its regulatory 
and clinical experts, decided to 
significantly amend the current 
protocol for the IIH EVOLVE trial 
and intends to seek requisite 
authorities’ feedback and ethics 
committee approvals for a 
revised protocol. 

The primary endpoint will 
remain unchanged, with the 
Group assessing the change in 
ICP from baseline at 24 weeks 
in the Presendin™ arm versus 
placebo in newly diagnosed 
IIH patients who have received 
a diagnostic lumbar puncture 
within 6 months of enrolment 
into the trial (previously 4 weeks). 
The protocol changes will focus 
on reordering of the secondary 
endpoints by replacing PMD as 
the key secondary endpoint with 
the more robust Quality of Life 
Short Form 36 (SF-36) Physical 
component score (PCS). 

INVEX THERAPEUTICS LTD.Overall, 57,000 TBI-related 
deaths and 1.5 million 
hospitalisations occur every 
year in the European Union. 
Management of ICP elevation 
is considered critical in patients 
with moderate to severe TBI, 
however, at present, there are no 
EMA or FDA approved therapies 
specifically for the treatment of 
intracranial hypertension in this 
patient population. 

In late Q4 of FY23 the Group 
filed an additional ODD for 
the US Market for moderate to 
severe TBI, which if granted in 
2H CY2023 will provide seven 
years market exclusivity for 
Exenatide, certain tax credits and 
a waiver from the Prescription 
Drug User Fee Act (PDUFA) 
fees, which were approximately 
US$3.1 million in 2022. A proof of 
concept clinical trial for Exenatide 
to lower ICP in moderate to 
severe TBI is under consideration.  

Following receipt of the report in 
mid Q3 CY 2023, the Board will 
be in a position to fully assess the 
market opportunity for Presendin™ 
in IIH in light of these new 
GLP-1RAs including Ozempic® 
and Wegovy®, their pricing 
structures and clinician attitudes 
to prescribing them to treat the 
obesity associated with IIH.

Orphan Drug Designation 
in Europe for Exenatide in 
Moderate to Severe Traumatic 
Brain Injury

On 23 June 2023, Invex 
announced the granting of 
orphan drug designation (ODD) 
from the EMA for Exenatide in the 
treatment of moderate to severe 
Traumatic Brain Injury (TBI). This 
is the second ODD for Exenatide 
in Europe, with Invex receiving an 
ODD for IIH in 2017, alongside an 
ODD from the US FDA. 

The EMA provides a range 
of incentives in the European 
Union (EU) for medicines that 
have been granted an orphan 
designation, including ten years 
market exclusivity from the 
date of approval, clinical trial 
protocol assistance, access to 
the centralised authorisation 
procedure in Europe, and certain 
fee reductions.

Independent Assessment – IIH 
Market Opportunity

On 28 June 2023 the Group 
announced it had engaged a 
specialised global healthcare 
intelligence group to undertake 
an analysis on the potential 
future risks to the addressable 
market for Presendin™ for IIH. 
This independent assessment was 
initiated following evidence of the 
growing use of approved GLP-1 
receptor agonists (GLP-1RA) for 
obesity management, specifically 
semaglutide, currently sold under 
the brand names Ozempic®, 
Wegovy® and Rybelsus®. 

Although these drugs have not 
been impacting recruitment 
of the IIH EVOLVE clinical trial, 
due to supply constraints of the 
approved GLP-1RAs in Europe, 
this is expected to normalise 
over time as capacity grows 
and supply increases. The link 
between obesity and IIH is well 
established. Patients with IIH are 
typically female, and more than 
90% of these sufferers are obese. 
The Group considers the use of 
these agents in the management 
of obesity particularly as a 
key potential future risk to the 
acceptability of Presendin™ as an 
orphan treatment in IIH noting 
this link. Weight loss is considered 
an effective treatment option 
for IIH sufferers as it lowers ICP. 
However, sustainable weight 
loss is challenging in IIH and 
across the obesity spectrum. 
Orphan drug developers like the 
Group typically rely on a higher 
priced intervention to recoup 
the significant costs associated 
with treating the small number 
of patients eligible for treatment 
with a rare disorder (such as IIH). 

3

ANNUAL REPORT 2023On behalf of the 
Board, we would 
like to express our 
sincere thanks to 
Dr Loveridge and 
Professor Sinclair for 
their tireless efforts 
in moving our 
Exenatide program 
in IIH into a Phase III 
clinical trial. 

Although the recent period 
has been a difficult one for the 
Company as we transition to 
a new trial design, both Jason 
and Alex, as co-founders of the 
Company, have been passionate 
advocates for Invex and the 
research we undertake to find 
treatments for patients with 
raised intracranial pressure, 
including IIH. We wish them 
all the very best in their 
future endeavours.

Chairman’s letter continued

Financials

The Group recorded a net loss 
after tax of $7.732 million for 
the year ended 30 June 2023 
(FY23), an increase of 80% on 
the prior corresponding period 
(pcp), this was largely due to 
higher R&D costs of $7.40 million 
(FY22: $2.962 million), reflecting 
the necessary regulatory and 
clinical expenditure required to 
commence the IIH EVOLVE study, 
along with product manufacturing 
costs of $0.744 million (FY22: 
$0.327 million) associated with 
the purchase of drug product 
(Presendin™) and placebo from 
Peptron. In addition share-
based payment expenses 
of $0.481 million (FY22: 
$0.352 million) and corporate 
and administrations costs of 
$1.125 million (FY22: $0.9 million) 
were recorded. 

The Group is structured utilising 
a global virtual business model, 
with a small number of highly 
experienced executives and 
employees based in the UK 
utilising additional expertise 
from clinical, regulatory and 
manufacturing consultants, as 
required, to progress our clinical 
program in Australia, the UK, 
Europe and the United States. 

The Group remains in a strong 
financial position with cash and 
cash equivalents of $22.47 million 
as at 30 June 2023  
(FY22: $29.339 million). 

Corporate Governance & 
Diversity

There were no changes to the 
Board composition during the 
year. However, shortly after the 
end of the year, on 3 July 2023 
we announced the resignations 
of Dr Jason Loveridge, Non-
Executive Chairman and Professor 
Alexandra Sinclair, Executive 
Director and Chief Scientific 
Officer, effective 10 July 2023. 

The resignations of Dr Loveridge 
and Professor Sinclair was in 
response to discussions with 
major shareholders who indicated 
to the Company that, following 
the ASX release on 28 June 2023, 
they no longer supported their 
positions as Directors of the 
Company. Consequently, both 
Directors felt it was in the best 
interests of all shareholders to 
tender their resignations.

Dr Loveridge has been Chairman 
of Invex since March 2019 and 
Professor Sinclair an Executive 
Director since June 2019. 
Both have made considerable 
contributions to the Company, 
including an IPO on ASX and 
material development of the 
Company’s therapeutic assets. 
I was afforded the opportunity 
to serve the Company as the 
Interim Non-Executive Chairman 
of the Company, effective 
10 July 2023. Professor Sinclair 
and Dr Loveridge will cease 
their engagement with the 
Company, consistent with their 
contractual commitments in the 
months ahead.

4

INVEX THERAPEUTICS LTD.In parallel, the Company awaits 
the outcome of the market 
assessment in IIH in mid Q3 
CY2023, which will assist the 
Board in determining whether to 
continue with the revised protocol 
change for the IIH EVOLVE Phase 
III clinical trial. 

We look forward to an improved 
2024 financial year as we 
continue the development of 
Presendin™ in neurological 
disorders associated with raised 
intracranial pressure and carefully 
manage our cash position in light 
of market conditions. 

Diversity in the workplace 
encompasses a wide range 
of perspectives, experiences, 
and backgrounds. Invex makes 
a significant commitment to 
diversity, which the Group sees 
as crucial for effective decision-
making and ensuring equitable 
representation. Our small team 
has demonstrated an exceptional 
willingness to collaborate, 
engage and execute. Female 
representation at the Board 
level was 40%. Excluding the 
Executive Directors, 100% of Invex 
employees are female.

Concluding Remarks

The 2023 financial year has 
proven a difficult one for the 
Company, given the need to 
re-design the IIH EVOLVE Phase 
III clinical trial in light of poor 
recruitment achieved since the 
first patient was enrolled in 
November 2022. The IIH EVOLVE 
trial has been re-designed to 
accelerate patient recruitment. 
Although the changes are 
expected to be cash neutral 
relative to the original design, 
to re-start the trial under the 
revised protocol is expected 
to take a number of months 
as the Company seeks the 
requisite regulatory and ethics 
committee approvals. 

Mr David McAuliffe

Interim Non-Executive Chairman

5

ANNUAL REPORT 2023 
Your Directors present their report together with the consolidated financial statements of Invex 
Therapeutics Ltd (Invex or Company) and its controlled entity (Group) for the financial year ended 
30 June 2023.

DIRECTORS

The name of the Directors in office for the year ended 30 June 2023 until the date of this report are as 
follows. All Directors were in office for the entire year unless otherwise stated.

Dr Thomas Duthy

Executive Director  
Appointed 1 October 2020

Dr Duthy has over 18 years of direct financial market and executive-level/Board experience with ASX 
listed companies. He is a Director and Founder of Nemean Group, which provides corporate advisory and 
investor relations (IR) services in the Life Sciences and Technology sectors. This included an IR/Corporate 
Development consultancy role with Nova Eye Medical (ASX:EYE), during which time a $100 million all-cash 
sale of their Lasers & Ultrasound business to Lumibird Group was completed (2020). He has also provided 
IR advisory services to Limeade (ASX:LME), which announced a $112 million all cash takeover by WebMD 
Health Services in June 2023, representing a 325% premium to the prevailing market price. 

Prior to establishing Nemean Group in October 2018, Dr Duthy was the Global Head of Investor Relations & 
Corporate Development at Sirtex Medical Limited (ASX:SRX), which was sold to CDH Investments in 
September 2018 for A$1.9 billion and remains the largest medical device transaction in Australian corporate 
history. Prior to Sirtex, Tom spent ten years as a leading sell-side Healthcare & Biotechnology analyst at 
Taylor Collison Limited, focused mainly on small cap companies. He is a Member of the Australian Institute 
of Company Directors (MAICD).

Current directorships – Neurotech International Limited and Arovella Therapeutics Limited.

Former directorships held in last three years – Respiri Limited - resigned 19 April 2022

Interests in shares and options – 106,923 shares and 1,800,000 unlisted options.

Mr David McAuliffe

Interim Non-executive Chairman 
Appointed 8 March 2019

Mr McAuliffe is an experienced company director and entrepreneur who has had over 24 years experience, 
mostly in the international biotechnology field. During that time, he was involved in numerous capital 
raisings and in-licensing of technologies. He is a founder of several companies in Australia, France and the 
United Kingdom, many of which have become public companies. Mr McAuliffe has an Honours degree in 
Law, a Bachelor of Pharmacy degree and is the President of the Dyslexia – Speld Foundation WA (Inc). 
Mr McAuliffe is considered an independent Director.

Current directorships – 4DS Memory Limited. 

Former directorships held in last three years – None.

Interests in shares and options – 3,350,001 shares and 200,000 unlisted options.

Dr Megan Baldwin
Non-executive Director 
Appointed 16 February 2021

Dr Baldwin is CEO and Managing Director of Opthea Limited (ASX:OPT; NASDAQ:OPT), a late-stage 
biopharmaceutical company developing a novel therapy, OPT-302, to address the unmet need in the 
treatment of retinal eye diseases, including wet age-related macular degeneration (wet AMD). Under 
Dr Baldwin’s leadership, Opthea has rapidly advanced its ophthalmology program through Phase I 
and Phase II clinical development and in October 2020 completed a $180 million IPO and listing 

6

INVEX THERAPEUTICS LTD.Directors’ Reporton the US NASDAQ exchange to progress two pivotal Phase III studies in wet AMD. Dr Baldwin is 
currently over-seeing the expansion of the company’s management team in the U.S. and preparing for 
commercialization of OPT-302.

Dr Baldwin is an experienced biotechnology executive, having over 20 years’ experience working on 
therapeutic drug development programs for cancer and ophthalmic indications. Prior to Opthea, Dr Baldwin 
was employed at Genentech (now Roche) as a postdoctoral researcher before moving to Genentech’s 
commercial division. Dr Baldwin also serves on the Board of Ausbiotech as Deputy Chair. Dr Baldwin is 
considered an independent Director.

Current directorships – Opthea Limited, Ausbiotech.

Former directorships held in last three years – None

Interests in shares and options – 600,000 unlisted options.

Dr Jason Loveridge
Non-executive Chairman 
Appointed 8 March 2019, resigned 10 July 2023

Dr Loveridge is a founder of Invex and also CEO of 4SC AG, a German publicly listed oncology company. He 
has more than 30 years of international experience across Europe, Asia and the US in senior management 
positions in life sciences companies and as an investment professional dealing in both privately held 
and publicly traded companies. Additionally, he has substantial transactional experience in the sale and 
partnering of biotechnology assets.

Dr Loveridge graduated in Biochemistry and Microbiology from the University of New South Wales, 
Australia, and holds a Ph.D. in Biochemistry from the University of Adelaide, Australia. He is also a fellow of 
the Royal Society of Medicine. Dr Loveridge is not considered an independent Director.

Current Directorships – Member of the Management Board of 4SC AG.

Former Directorships in last three years – None

Interests in shares and options – 3,374,462 shares and 2,080,000 unlisted options.

Professor Alexandra Sinclair
Executive Director – Chief Scientific Officer 
Appointed 28 June 2019, resigned 10 July 2023

Prof Alexandra Sinclair is a founder of Invex Therapeutics and a Clinician Scientist and practicing 
Neurology Consultant running the Translational Brain Science Group at the Institute of Metabolism and 
Systems Research, College of Medical and Dental Sciences, University of Birmingham, UK. She runs the 
Headache Service and Idiopathic Intracranial Hypertension Service at University Hospital Birmingham 
NHS Foundation Trust. 

Prof Sinclair pioneered the pre-clinical work identifying GLP-1RA’s as a novel therapeutic approach 
to reduce brain pressure which she then progressed into a successful phase 2 clinical trial. She runs a 
translational research group focussed on developing novel therapeutics with forward translation to improve 
patient care. She is a member of the British Medical Association, UK, the Association of British Neurologists 
(ABN), UK and a Fellow of the Royal College of Physicians, London,. Prof Sinclair is a member of the 
board for the European Headache Federation and is on the scientific committees for the North American 
Neuro-Ophthalmology Society (NANOS). She is also a council member for the British Association for the 
Study of Headache (BASH). Prof Sinclair has served on the MRC Neuroscience and Mental Health Board and 
the Midland Neuroscience Teaching and Research Fund Board, as well as being Chair of the Brain Research 
UK Scientific Advisory Board. Previously, she was an elected board member of the IHS. She was on the 
research committee for the Association for British Neurologists and was also the previous patron of the 
patient charity IIH UK.

Current directorships – None.

Former directorships held in last three years – None.

Interests in shares and options – 2,500,000 shares and 1,920,000 unlisted options.

7

ANNUAL REPORT 2023Ms Narelle Warren 

Company Secretary

Ms Warren is a Chartered Accountant with over twenty years of corporate advisory, financial management 
and company secretarial experience. Ms Warren has coordinated and assisted in numerous corporate 
transactions, including acquisitions, divestments and raising funds via private and public equity markets. 
She holds both a Bachelor of Laws and Bachelor of Commerce. 

PRINCIPAL ACTIVITY

Invex is a biopharmaceutical Group focused on the repurposing of an already approved drug, Exenatide, 
for efficacious treatment of neurological conditions derived from or involving raised intracranial pressure 
(ICP). The Group’s primary focus is Idiopathic Intracranial Hypertension (IIH), a severe condition of 
predominately overweight women of childbearing age, which can lead to disabling headaches and in some 
patients, permanent vision loss. The Group’s lead program is the development of Presendin™ for IIH, which 
is currently at Phase III clinical stage.

Presendin™ is a once per week, subcutaneous, sustained-release (SR) Exenatide microsphere formulation 
originally developed by Peptron, Inc. (KOSDAQ: 087010). Invex completed a Phase II trial in 2020 and 
commenced a single, Phase III clinical trial (“IIH EVOLVE”) designed to meet the requirements for market 
approval of Presendin™ for the treatment of IIH in the European Union (EU), United Kingdom (UK) and 
Australia in November 2022. 

Presendin™ is the Group’s filed (and granted) trademark name for reformulated Exenatide.

The principal activity of the Group during the year has been to manage the Phase III IIH EVOLVE clinical 
trial and explore new potential applications for Exenatide in Traumatic Brain Injury and other neurological 
disorders with raised ICP, consistent with the Group’s patents.

OPERATING RESULTS

The result of the Group for the year ended 30 Jun 2023 was a loss of $7,731,713 (2022: $3,950,183 loss). The 
net loss of the Group predominantly related to Research & Development costs of $7.40 million associated 
with the Phase III clinical trial, intellectual property prosecution, manufacturing costs and regulatory advice, 
administration and corporate costs of $1.125 million and non-cash items; notably share-based payments of 
$0.481 million.

REVIEW OF OPERATIONS

The Group is well funded to meet its medium-term objectives, including the completion of a Phase III trial 
for Presendin™ in IIH, with the associated drug manufacture and supply for the Phase III trial. In addition, the 
Group may consider the commencement of a small Phase II study for Presendin™ in a second patient group, 
likely to be moderate to severe TBI. 

FY23 highlights include:

•  Regulatory approvals and Human Research Ethics Committee clearance to commence IIH EVOLVE in 

Australia, New Zealand, Germany, France, Israel, the UK and the US 

•  First patient recruited into IIH EVOLVE 

•  Paediatric Committee (PDCO) of the European Medicines Agency (EMA) approval of the Paediatric 

Investigation Plan (PIP) for paediatric development of Presendin™ in IIH

•  Publication of the Invex Phase II ‘Pressure’ clinical trial in the Journal Brain, which provided initial safety 

and efficacy of Exenatide in IIH patients

•  Orphan drug designation (ODD) from the EMA for Exenatide in the treatment of moderate to severe TBI

8

INVEX THERAPEUTICS LTD.Directors’ Report continuedLIKELY DEVELOPMENTS

The Group has undertaken a significant amount of clinical and regulatory preparative work during FY23 and 
has commenced patient recruitment in the Phase III IIH EVOLVE clinical trial across a number of countries. 
Due to slower than anticipated patient recruitment the Group has re-designed the IIH EVOLVE clinical trial 
to accelerate recruitment. However, the implementation of the revised clinical trial is contingent on the 
findings from an independent assessment and report on the potential future risks to the addressable market 
for Presendin™ for IIH by a specialised global healthcare intelligence group. 

DIVIDENDS

No dividends were paid or recommended by the Directors since the commencement of the year.

SIGNIFICANT CHANGES IN STATE OF AFFAIRS

Other than as outlined above, there were no significant changes in the Group’s state of affairs during the 
year.

MATTERS SUBSEQUENT TO THE END OF THE FINANCIAL YEAR

On 10 July 2023 Dr Jason Loveridge and Professor Alexandra Sinclair resigned as Directors of the Company.

No other significant events occurred after balance date which may affect either the Group’s operations or 
results of those operations or the Group’s state of affairs.

MEETINGS OF DIRECTORS

During the year the following Director meetings were held.

Director

Dr Thomas Duthy

Mr David McAuliffe

Dr Megan Baldwin

Dr Jason Loveridge

Prof Alexandra Sinclair

Board Meetings

Number Eligible 

to Attend Number Attended

7

7

7

7

7

7

7

6

7

6

ENVIRONMENTAL REGULATIONS

The Group is not subject to significant environmental regulation in respect of its research and development 
activities.

UNISSUED SHARES UNDER OPTION

Unissued ordinary shares of Invex Therapeutics Ltd under option at the date of this report are as follows:

Date Options Granted

Expiry Date

Exercise Price

22 November 2019

22 November 2023

20 October 2020

20 October 2023

18 November 2020

18 November 2023

8 April 2021

22 November 2022

1 December 2022

Total

8 April 2024

1 December 2026

1 December 2026

$0.60

$1.30

$1.30

$1.10

$0.87

$0.87

Number Under 
Option

2,200,000

400,000

800,000

400,000

3,600,000

1,792,000

9,192,000

9

ANNUAL REPORT 2023INSURANCE OF OFFICERS AND INDEMNITIES

Invex paid a premium to insure the Directors and Secretary of the Group.

The liabilities insured are legal costs that may be incurred in defending civil or criminal proceedings that 
may be brought against the officers in their capacity as officers of entities in the Group, and any other 
payments arising from liabilities incurred by the officers in connection with such proceedings. This does 
not include such liabilities that arise from conduct involving a wilful breach of duty by the officers or the 
improper use by the officers of their position or of information to gain advantage for them or someone else 
or to cause detriment to the Group. It is not possible to apportion the premium between amounts relating 
to the insurance against legal costs and those relating to other liabilities. 

PROCEEDINGS ON BEHALF OF THE GROUP

No person has applied to the Court under section 237 of the Corporations Act 2001 for leave to bring 
proceedings on behalf of the Group, or to intervene in any proceedings to which the Group is a party, for 
the purpose of taking responsibility on behalf of the Group for all or part of those proceedings.

No proceedings have been brought or intervened in on behalf of the Group with leave of the Court under 
section 237 of the Corporations Act 2001.

NON-AUDIT SERVICES

The Group may decide to employ its auditor on assignments additional to their statutory audit duties where 
the auditor’s expertise and experience with the Group is important.

During the year, other services were performed in addition to their statutory duties. The details of the 
amount paid are disclosed in Note 20 of the consolidated financial report. 

AUDITOR’S INDEPENDENCE DECLARATION

A copy of the auditor's independence declaration as required under section 307C of the Corporations 
Act 2001 is set out on the page following this Directors’ Report.

REMUNERATION REPORT - AUDITED

The remuneration report outlines the remuneration arrangements which were in place during the year and 
remain in place as at the date of this report, for the Directors and Key Management Personnel of the Group.

The information provided in this remuneration report has been audited as required by section 308(3C) of 
the Corporations Act 2001.

KEY MANAGEMENT PERSONNEL

Key Management Personnel are those persons who are responsible for directing and controlling the 
activities of the Group. The Board has determined that the key management personnel of the Group are 
the Non-executive Directors and Executives of Invex, whose details are set out below. The following Key 
Management Personnel during the period unless otherwise stated:

Director

Date of appointment/resignation

Role

Dr Jason Loveridge

Prof Alexandra Sinclair

Appointed 8 March 2019/  
Resigned 10 July 2023

Appointed 28 June 2019/  
Resigned 10 July 2023

Non-executive Chair

Executive Director

Dr Thomas Duthy

Dr Megan Baldwin

David McAuliffe

Narelle Warren

Carol Parish

10

Appointed 1 October 2020

Executive Director

Appointed 16 February 2021

Non-executive Director

Appointed 8 March 2019

Appointed 8 March 2019

Appointed 1 July 2022

Non-executive Director

CFO & Company Secretary

Chief Operating Officer

INVEX THERAPEUTICS LTD.Directors’ Report continuedREMUNERATION POLICIES

The Board has not elected to establish a remuneration committee. Given the size of the current Board 
remuneration matters will be considered and approved by the full Board.

The following items will be considered and discussed as deemed necessary at the Board meetings:

•  recommend the terms and conditions of employment for the Executive Directors and Senior Officers;

•  undertake a review of the Executive Directors’ performance, at least annually, including setting the 
Executive Directors goals for the coming year and reviewing progress in achieving those goals;

•  consider and report on the recommendations of the Executive Directors on the remuneration of all direct 

reports; and

•  develop and facilitate a process for Board and Director evaluation.

Non-executive Director’s remuneration

The compensation of Non-executive Directors is based on market practice, Director’s duties and the level of 
accountability. The compensation policy is designed to attract and retain competent and suitably qualified 
Non-executive Directors and aims to align Director’s interests with interests of shareholders. Non-executive 
Directors are paid a set fee plus statutory superannuation where appropriate, and are reimbursed for out-
of-pocket expenses

The Chair’s fees are determined independently to the fees of Non-executive Directors based on 
comparative roles in the external market. 

The base fees are reviewed annually and were last reviewed at a recent Board meeting. Non-executive 
Directors’ fees are determined within an aggregate directors’ fee pool limit, which is periodically 
recommended for approval by shareholders. The current limit stands at $400,000 per annum and was 
approved by shareholders at its Annual General Meeting of shareholders in November 2021.

A Director may also be paid fees or other amounts as the Directors determine if a Director performs special 
duties or otherwise performs services outside the scope of the ordinary duties of a Director.

Executive remuneration

In determining executive remuneration, the Board aims to ensure that remuneration practices are:

•  competitive and reasonable, enabling the Company to attract and retain key talent;

•  aligned to the Company’s strategic and business objectives and the creation of shareholder value;

•  transparent; and

•  acceptable to shareholders.

The executive remuneration framework has three components:

• 

fixed annual compensation comprising salary or fees and benefits, including superannuation;

•  short-term performance incentives; and

• 

long-term incentives through participation in the Invex Employee Share Option Plan.

Fixed annual compensation

Executives receive their base salary/fees and benefits structured as a total employment cost (TEC) package 
which may be delivered as a combination of cash and prescribed non-financial benefits at the executives’ 
discretion. 

Executives are offered a competitive base pay that comprises the fixed component of pay and rewards. 
Independent remuneration consultants provide analysis and advice to ensure base pay is set to reflect the 
market for a comparable role. 

Base pay for executives is reviewed annually to ensure the executive’s pay is competitive with the market. 
An executive’s pay is also reviewed on promotion. 

11

ANNUAL REPORT 2023There are no guaranteed base pay increases included in any executives’ contracts.

There are no short-term incentives outstanding.

No benefits other than noted above are paid to Directors or management except as incurred in normal 
operations of the business.

Short term incentives

No benefits other than remuneration disclosed in the remuneration report are paid to Directors or 
management except as incurred in normal operations of the business.

Long term incentives

The Group’s current Employee Share Incentive Plan (ESIP) is designed to provide medium and long term 
incentives for all employees (including Non-executive and Executive Directors) and to attract and retain 
experienced Employees, Board Members and Executive Officers and provide motivation to make the Group 
more successful. 

As incentive securities granted to Directors and Employees are considered to represent the value of the 
services received over the vesting period of the incentive security, the assessed value of the options are 
recognised and expensed over the vesting period. Incentive securities vesting during the period of issue are 
fully expensed under the accounting standards.

Other than incentive securities disclosed in the remuneration report there have been no options issued to 
Directors at the date of this financial report.

Voting and comments made at the Company's 2022 Annual General Meeting (AGM)

At the 2022 AGM, 93.9% of the votes received supported the adoption of the remuneration report for the 
year ended 30 June 2022. The Company did not receive any specific feedback at the AGM regarding its 
remuneration practices.

Remuneration consultants

The Group did not engage any remuneration consultants during the year.

The Group may engage independent remuneration consultants should it look to make any changes to 
director fee levels to ensure they are in line with market conditions and any decisions are made free from 
undue influence from members of the Group’s Key Management Personnel (KMP’s).

Service agreements

The details of the key terms of the revised agreements are set out below:

Name

Executive Directors

Term of  
agreement

Prof Alexandra Sinclair  Open

Remuneration

Termination benefit

£145,000 
plus statutory 
pension duties

Relevant notice periods apply, being 
1 months’ notice with reason or 
3 months without reason.

Dr Thomas Duthy 

Open

$180,000

Relevant notice periods apply, being 
1 months’ notice with reason or 
3 months without reason.

12

INVEX THERAPEUTICS LTD.Directors’ Report continuedThe relative proportions of remuneration that are linked to performance and those that are fixed are as 
follows:

Name

Executive Directors

Prof Alexandra Sinclair

Dr Thomas Duthy

Non-executive Directors

Fixed 
remuneration 
2023

Performance 
based 
remuneration (%) 
2023

$299,420

$180,000

22.17

35.88

On appointment to the Board, all Non-executive Directors enter into a service agreement with the Company 
in the form of a letter of appointment. The letter summarises the Board’s policies and terms, including 
compensation, relevant to the director, and among other things:

•  the terms of the directors appointment, including governance, compliance with the Company’s 

Constitution, committee appointments, and re-election;

•  the directors duties, including disclosure obligations, exercising powers, use of office, attendance at 

meetings and commitment levels;

•  the fees payable, in line with shareholder approval, any other terms, timing of payments and 

entitlements to reimbursements; 

• 

insurance and indemnity;

•  disclosure obligations; and

•  confidentiality.

The Non-executive Director fees paid during the year:

Name

Non-Executive Directors

Dr Jason Loveridge – 
Consultancy

Dr Jason Loveridge – 
Non-executive  
Chairman fee

Term of  
agreement

Remuneration

Termination benefit

Open

£110,000

Relevant notice periods apply, being 
3 months’ notice without reason.

Shareholder 
Approval by rotation

$60,000

Nil

Dr Megan Baldwin – 
Non-executive fee

Shareholder 
Approval by rotation

David McAuliffe – 
Non-executive fee

Shareholder 
Approval by rotation

$50,000

$50,000

Nil

Nil

13

ANNUAL REPORT 2023-
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15

ANNUAL REPORT 2023 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
SHARE-BASED COMPENSATION 

Incentive Securities

The Company’s current Employee Incentive Plan (ESIP) was approved by Shareholders on 25 November 
2021 and the previous Employee Incentive Option Plan (ESOP) was approved by the Board of Directors 
on 20 May 2019. The Incentive Plans are designed to provide medium and long term incentives for all 
employees (including Non-executive and Executive Directors) and to attract and retain experienced 
employees, board members and executive officers and provide motivation to make the Company more 
successful. 

Under the ESIP, participants have not yet been granted incentive securities. Incentive securities only vest 
if certain milestones are met. Participation in the plan is at the Board’s discretion and no individual has a 
contractual right to participate in the plan or to receive any guaranteed benefit.

Any option may only be exercised after the option has vested and other conditions imposed by the Board 
have been satisfied. Options were granted under the ESOP for no consideration. Options granted under 
the ESOP carry no dividend or voting rights. When exercisable, shares allotted pursuant to the exercise of 
options will be allotted following receipt of relevant documentation and payments will rank equally with all 
other shares.

As options granted to employees are considered to represent the value of the services received over 
the vesting period of the options, the assessed value of the options is recognised and expensed over 
the vesting period. Options vesting during the period of issue are fully expensed under the accounting 
standards. 

During the year 30 June 2023 there were 5,448,000 unlisted options granted, no options were cancelled 
and 810,000 options were forfeited. 

Details of the share-based component issued during the year included in the remuneration are set out 
below. 

EQUITY INSTRUMENTS HELD BY KEY MANAGEMENT PERSONNEL

Shareholdings

The numbers of shares in the Company held during the year by each director or key management personnel 
of Invex, including their personally related parties are set out below. There were no shares granted during 
the reporting year as compensation.

Capital 
Raising 
shares 
subscribed 
for

On Market 
Purchases/ 
On 
appointment

Balance at 
the end of 
the year

Disposals

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

—

3,374,426

2,500,000

106,923

3,350,001

—

200,000

—

9,531,350

Balance at 
the start of 
the year

3,374,426

2,500,000

106,923

3,350,001

—

200,000

—

9,531,350

2023 
Name

Directors

Dr Jason Loveridge

Prof. Alexandra Sinclair

Dr Thomas Duthy

David McAuliffe

Dr Megan Baldwin

Narelle Warren

Carol Parish

Total

16

INVEX THERAPEUTICS LTD.Directors’ Report continued2023 
Name

Directors and 
KMP’s

Dr Jason 
Loveridge

Prof Alexandra 
Sinclair

Dr Thomas 
Duthy

David 
McAuliffe

Dr Megan 
Baldwin

Option holdings

The number of options over ordinary shares in the Company held during the year by each director and KMP 
of Invex Therapeutics Ltd, including their personally related parties, are set out below.

Balance at 
the start of 
the year

Granted as 
compensation

Exercised/
Expired

Balance at 
end of the 
year

Vested and 
exercisable Un-vested

Fair value  
at grant 
date

800,000

1,280,000

— 2,080,000

800,000 1,280,000 $0.42/$0.21

800,000

1,120,000

— 1,920,000

800,000 1,120,000 $0.42/$0.21

800,000

1,000,000

— 1,800,000

800,000 1,000,000 $0.32/$0.21

200,000

—

Narelle Warren

400,000

400,000

200,000

448,000

—

—

—

200,000

200,000

—

$0.42 

600,000

200,000

400,000 $0.33/$0.21

848,000

400,000

448,000 $0.42/$0.23

Carol Parish

400,000

1,120,000

1,520,000

400,000 1,120,000 $0.35/$0.23

Total

3,800,000

5,168,000

— 8,968,000 3,600,000 5,368,000

LOANS WITH KEY MANAGEMENT PERSONNEL

There were no loans to or from key management personnel during the year ended 30 June 2023.

OTHER TRANSACTIONS WITH KEY MANAGEMENT PERSONNEL

There were no other services provided with key management personnel which are not disclosed.

This is the end of the Remuneration Report.

Signed in accordance with a resolution of the Board of Directors.

David McAuliffe
Interim Non-executive Chairman
Perth, Western Australia, 17 August 2023

17

ANNUAL REPORT 2023Auditors’ Independence Declaration

Tel: +61 8 6382 4600
Fax: +61 8 6382 4601
www.bdo.com.au

Level 9, Mia Yellagonga Tower 2
5 Spring Street
Perth WA 6000
PO Box 700 West Perth WA 6872
Australia

DECLARATION OF INDEPENDENCE BY JARRAD PRUE TO THE DIRECTORS OF INVEX THERAPEUTICS
LTD

As lead auditor of Invex Therapeutics Ltd for the year ended 30 June 2023, I declare that, to the best
of my knowledge and belief, there have been:

1. No contraventions of the auditor independence requirements of the Corporations Act 2001 in

relation to the audit; and

2. No contraventions of any applicable code of professional conduct in relation to the audit.

This declaration is in respect of Invex Therapeutics Ltd and the entity it controlled during the period.

Jarrad Prue

Director

BDO Audit (WA) Pty Ltd

Perth

17 August 2023

BDO Audit (WA) Pty Ltd ABN 79 112 284 787 is a member of a national association of independent entities which are all members of BDO Australia
Ltd ABN 77 050 110 275, an Australian company limited by guarantee. BDO Audit (WA) Pty Ltd and BDO Australia Ltd are members of BDO
International Ltd, a UK company limited by guarantee, and form part of the international BDO network of independent member firms. Liability
limited by a scheme approved under Professional Standards Legislation.

18

INVEX THERAPEUTICS LTD.Consolidated Statement  
of Profit or Loss and Other Comprehensive Income

For the year ended 30 June 2023

Other income

Research and development expenditure

Finance, compliance and administration expenses

Share-based payment expenses

Loss before income tax from continuing operations

Income tax expense/benefit

Note

2023 
$

2022 
$

4

5

5

17

6

1,256,168

262,132

(7,400,491)

(2,962,596)

(1,124,992)

(900,286)

(480,541)

(352,390)

(7,749,856)

(3,953,140)

—

—

Loss for the year from continuing operations

(7,749,856)

(3,953,140)

Other comprehensive income for the year, net of tax

Items that may be reclassified subsequently to profit or loss

—

—

Exchange differences on translation of foreign operations, 
net of tax

Total other comprehensive income for the year, net of tax 
attributable to members of the Group

10

18,143

2,957

(7,731,713)

(3,950,183)

Loss for the year is attributable to:

Owners of Invex Therapeutics Ltd

(7,731,713)

(3,950,183)

Total comprehensive income for the year is attributable to:

Owners of Invex Therapeutics Ltd 

(7,731,713)

(3,950,183)

Loss per share (cents)

11

(10.31)

(5.26)

The above Consolidated Statement of Profit or Loss and Other Comprehensive Income should be read in 
conjunction with the accompanying notes.

19

ANNUAL REPORT 2023Consolidated Statement  
of Financial Position

AS AT 30 JUNE 2023

ASSETS

Current Assets

Cash and cash equivalents

7

22,470,243

29,339,382

Note

2023 
$

2022 
$

Other receivables

Total Current Assets

TOTAL ASSETS

LIABILITIES

Current Liabilities

Trade and other payables

Total Current Liabilities

TOTAL LIABILITIES

NET ASSETS

EQUITY

Contributed equity

Reserves

Accumulated losses

TOTAL EQUITY

333,565

145,715

22,803,808

29,485,097

22,803,808

29,485,097

8

1,572,370

1,004,214

1,572,370

1,004,214

1,572,370

1,004,214

21,231,438

28,480,883

9

10

12

36,413,432

36,413,432

2,397,314

1,896,903

(17,579,308)

(9,829,452)

21,231,438

28,480,883

The above Consolidated Statement of Financial Position should be read in conjunction with the 
accompanying notes.

20

INVEX THERAPEUTICS LTD.Consolidated Statement  
of Changes in Equity

For the year ended 30 June 2023

Contributed 
Equity 
$

Accumulated 
Losses 
$

Reserves 
$

Total 
Equity 
$

Balance as at 1 July 2022

36,413,432

(9,829,452)

1,896,903

28,480,883

(Loss) for the year

Other comprehensive income for the year

Total comprehensive (loss) for the year

Fx reserve movement

Share-based payment reserve movement

Transactions with owners in their capacity as 
owners:

Issue of share capital, net of transaction costs

—

—

—

—

—

—

(7,749,856)

—

(7,749,856)

—

—

—

—

—

—

—

19,870

480,541

—

—

(7,749,856)

—

(7,749,856)

19,870

480,541

—

—

Balance as at 30 June 2023

36,413,432

(17,579,308)

2,397,314

21,231,438

Contributed 
Equity 
$

Accumulated 
Losses 
$

Reserves 
$

Total 
Equity 
$

Balance as at 1 July 2021

36,413,432

(5,876,312)

1,541,556

32,078,676

(Loss) for the year

Other comprehensive income for the year

Total comprehensive (loss) for the year

Fx reserve movement

Share-based payment reserve movement

Transactions with owners in their capacity as 
owners:

Issue of share capital, net of transaction costs

—

—

—

—

—

—

(3,953,140)

—

(3,953,140)

—

—

—

—

—

—

—

(3,953,140)

—

(3,953,140)

2,957

2,957

352,390

352,390

—

—

—

—

Balance as at 30 June 2022

36,413,432

(9,829,452)

1,896,903

28,480,883

The above Consolidated Statement of Changes in Equity should be read in conjunction with the 
accompanying notes.

21

ANNUAL REPORT 2023Consolidated Statement  
of Cash Flows

For the year ended 30 June 2023

CASH FLOWS FROM OPERATING ACTIVITIES

Payments to suppliers and employees

R&D Tax rebate

Interest received

Net cash outflow from operating activities

CASH FLOWS FROM FINANCING ACTIVITIES

Subscription proceeds received for ordinary shares 

Placement capital raising costs

Net cash inflow from financing activities

Note

2023 
$

2022 
$

(8,125,307)

(3,638,841)

459,085

797,083

182,251

79,881

(6,869,139)

(3,376,709)

—

—

—

—

—

—

Net decrease in cash and cash equivalents held

Cash and cash equivalents at the beginning of the year

(6,869,139)

(3,376,709)

29,339,382

32,716,091

Cash and cash equivalents at end of financial year

7

22,470,243

29,339,382

The above Consolidated Statement of Cash Flows should be read in conjunction with accompanying 
the notes.

22

INVEX THERAPEUTICS LTD.1. BASIS OF PREPARATION

The financial report is a general purpose financial report that has been prepared in accordance 
with Australian Accounting Standards, Australian Accounting Interpretations, other authoritative 
pronouncements of the Australian Accounting Standards Board and the Corporations Act 2001.

Invex Therapeutics Limited is a listed public company, incorporated and domiciled in Australia and is the 
parent entity. Invex Therapeutics Limited is a for-profit entity for the purpose of preparing the financial 
statements. 

These consolidated financial statements comprise the Company and its controlled entity at the end of, 
or during the year (together referred to as ‘the Group’) and were authorised for issue by the Board of 
Directors.

Australian Accounting Standards set out accounting policies that the AASB has concluded would result in 
a financial report containing relevant and reliable information about transactions, events and conditions. 
Compliance with Australian Accounting Standards ensures that the financial statements and notes also 
comply with International Financial Reporting Standards as issued by the IASB. Material accounting policies 
adopted in the preparation of this financial report are presented below and have been consistently applied 
unless otherwise stated.

The financial report has been prepared on an accruals basis and is based on historical costs, modified, 
where applicable, by the measurement at fair value of selected non-current assets, financial assets and 
financial liabilities.

2. NEW AND AMENDED ACCOUNTING STANDARDS AND INTERPRETATIONS 

The consolidated entity has adopted all of the new or amended Accounting Standards and Interpretations 
issued by the Australian Accounting Standards Board ('AASB') that are mandatory for the current reporting 
period.

Any new or amended Accounting Standards or Interpretations that are not yet mandatory have not been 
early adopted.

3. SUMMARY OF ACCOUNTING POLICIES

The following material accounting policies adopted by the Group in the preparation of the financial report, 
have been consistently applied unless otherwise stated. 

(a) Parent entity information

In accordance with the Corporations Act 2001, these financial statements present the results of the 
consolidated entity only. Supplementary information about the parent entity is disclosed in note 19.

(b) Principles of consolidation

The consolidated financial statements incorporate the assets and liabilities of all subsidiaries of Invex 
Therapeutics Ltd (Company or Invex) as at 30 June 2023 and the results of all subsidiaries for the year then 
ended. Invex Therapeutics Ltd and its subsidiary together are referred to in these financial statements as 
the 'consolidated entity’.

Subsidiaries are all those entities over which the consolidated entity has control. The consolidated entity 
controls an entity when the consolidated entity is exposed to, or has rights to, variable returns from its 
involvement with the entity and has the ability to affect those returns through its power to direct the 
activities of the entity. Subsidiaries are fully consolidated from the date on which control is transferred to 
the consolidated entity. They are de-consolidated from the date that control ceases.

Intercompany transactions, balances and unrealised gains on transactions between entities in the 
consolidated entity are eliminated. Unrealised losses are also eliminated unless the transaction provides 
evidence of the impairment of the asset transferred. Accounting policies of subsidiaries have been changed 
where necessary to ensure consistency with the policies adopted by the consolidated entity.

The acquisition of subsidiaries is accounted for using the acquisition method of accounting.

23

ANNUAL REPORT 2023Notes to the Consolidated Financial Statements(c) Foreign currency translation

The financial statements are presented in Australian dollars, which is Invex's functional and presentation 
currency.

Foreign currency transactions
Foreign currency transactions are translated into Australian dollars using the exchange rates prevailing 
at the dates of the transactions. Foreign exchange gains and losses resulting from the settlement of such 
transactions and from the translation at financial year-end exchange rates of monetary assets and liabilities 
denominated in foreign currencies are recognised in profit or loss.

Foreign operations
The assets and liabilities of foreign operations are translated into Australian dollars using the exchange rates 
at the reporting date. The revenues and expenses of foreign operations are translated into Australian dollars 
using the average exchange rates, which approximate the rates at the dates of the transactions, for the 
period. All resulting foreign exchange differences are recognised in other comprehensive income through 
the foreign currency reserve in equity.

The foreign currency reserve is recognised in profit or loss when the foreign operation or net investment is 
disposed of.

(d) Operating segments

Operating segments are presented using the 'management approach', where the information presented is 
on the same basis as the internal reports provided to the Chief Operating Decision Makers ('CODM'). The 
CODM is responsible for the allocation of resources to operating segments and assessing their performance.

(e) Revenue recognition

Revenue is recognised when or as the Group transfers control of goods or services to a customer at the 
amount at which the Group expects to be entitled. The following specific recognition criteria must also be 
met before revenue is recognised:

Interest income
Revenue is recognised as the interest accrues (using the effective interest method), which is the rate that 
exactly discounts estimated future cash receipts through the expected life of the financial instrument to the 
net carrying amount of the financial asset. 

(f) Loans and Receivables

Loans and receivables are non-derivative financial assets with fixed or determinable payments that are not 
quoted in an active market and are stated at amortised cost using the effective interest rate method.

At each reporting date, the Group assesses whether there is objective evidence that a financial instrument 
has been impaired. 

(g) Cash and Cash Equivalents

Cash and short-term deposits in the Statement of Financial Position comprise cash at bank and on hand 
and short-term deposits.

(h) Right-of-use asset

A right-of-use asset is recognised at the commencement date of a lease. The right-of-use asset is measured 
at cost, which comprises the initial amount of the lease liability, adjusted for, as applicable, any lease 
payments made at or before the commencement date net of any lease incentives received, any initial direct 
costs incurred, and, except where included in the cost of inventories, an estimate of costs expected to be 
incurred for dismantling and removing the underlying asset, and restoring the site or asset.

Right-of-use assets are depreciated on a straight-line basis over the unexpired period of the lease or the 
estimated useful life of the asset, whichever is the shorter. Where the consolidated entity expects to obtain 
ownership of the leased asset at the end of the lease term, the depreciation is over its estimated useful life. 
Right-of use assets are subject to impairment or adjusted for any remeasurement of lease liabilities.

24

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continuedThe consolidated entity has elected not to recognise a right-of-use asset and corresponding lease liability 
for short-term leases with terms of 12 months or less and leases of low-value assets. Lease payments on 
these assets are expensed to profit or loss as incurred.

(i) Lease liability

A lease liability is recognised at the commencement date of a lease. The lease liability is initially recognised 
at the present value of the lease payments to be made over the term of the lease, discounted using the 
interest rate implicit in the lease or, if that rate cannot be readily determined, the consolidated entity's 
incremental borrowing rate. Lease payments comprise of fixed payments less any lease incentives 
receivable, variable lease payments that depend on an index or a rate, amounts expected to be paid under 
residual value guarantees, exercise price of a purchase option when the exercise of the option is reasonably 
certain to occur, and any anticipated termination penalties. The variable lease payments that do not depend 
on an index or a rate are expensed in the period in which they are incurred.

Lease liabilities are measured at amortised cost using the effective interest method. The carrying amounts 
are remeasured if there is a change in the following: future lease payments arising from a change in an index 
or a rate used; residual guarantee; lease term; certainty of a purchase option and termination penalties. 
When a lease liability is remeasured, an adjustment is made to the corresponding right-of use asset, or to 
profit or loss if the carrying amount of the right-of-use asset is fully written down.

(j) Goods and Services Tax (GST)

Revenues, expenses and assets are recognised net of the amount of GST, except where the amount of GST 
incurred is not recoverable from the Tax Office. In these circumstances the GST is recognised as part of 
the cost of acquisition of the asset or as part of an item of the expense. Receivables and payables in the 
statement of financial position are shown inclusive of GST. 

Cash flows are presented in the statement of cash flows on a gross basis, except for the GST components of 
investing and financing activities, which are disclosed as operating cash flows.

(k) Trade and Other Receivables

Trade receivables, which generally have 30-90 day terms, are recognised and initially at fair value and 
subsequently measured at amortised cost using the effective interest rate method, less loss allowance.

The Group applies the AASB 9 simplified approach to measure expected credit losses which uses lifetime 
expected loss allowance for trade receivables. Bad debts are written off when identified.

(l) Trade and other Payables

Trade and other payables represent liabilities for goods and services provided to the Group prior to the 
period end and which are unpaid. These amounts are unsecured, have 30-60 day payment terms and are 
measured at amortised cost.

(m) Share-based payments

Equity-settled and cash-settled share-based compensation benefits are provided to employees.

Equity-settled transactions are awards of shares, or options over shares, that are provided to employees in 
exchange for the rendering of services. Cash-settled transactions are awards of cash for the exchange of 
services, where the amount of cash is determined by reference to the share price.

The cost of equity-settled transactions are measured at fair value on grant date. Fair value is independently 
determined using either the Binomial or Black-Scholes option pricing model that takes into account the 
exercise price, the term of the option, the impact of dilution, the share price at grant date and expected 
price volatility of the underlying share, the expected dividend yield and the risk free interest rate for the 
term of the option, together with non-vesting conditions that do not determine whether the consolidated 
entity receives the services that entitle the employees to receive payment. No account is taken of any other 
vesting conditions.

25

ANNUAL REPORT 2023The cost of equity-settled transactions are recognised as an expense with a corresponding increase in 
equity over the vesting period. The cumulative charge to profit or loss is calculated based on the grant date 
fair value of the award, the best estimate of the number of awards that are likely to vest and the expired 
portion of the vesting period. The amount recognised in profit or loss for the period is the cumulative 
amount calculated at each reporting date less amounts already recognised in previous periods.

The cost of cash-settled transactions is initially, and at each reporting date until vested, determined by 
applying either the Binomial or Black-Scholes option pricing model, taking into consideration the terms and 
conditions on which the award was granted. The cumulative charge to profit or loss until settlement of the 
liability is calculated as follows:

•  during the vesting period, the liability at each reporting date is the fair value of the award at that date 

multiplied by the expired portion of the vesting period.

• 

from the end of the vesting period until settlement of the award, the liability is the full fair value of the 
liability at the reporting date.

All changes in the liability are recognised in profit or loss. The ultimate cost of cash-settled transactions is 
the cash paid to settle the liability.

(n) Equity, reserves and dividend payments

Share capital represents the fair value of shares that have been issued. Any transaction costs associated 
with the issuing of shares are deducted from share capital, net of any related income tax benefits. 

Dividend distributions payable to equity shareholders are included in other liabilities when the dividends 
have been approved in a General Meeting prior to the reporting date. 

All transactions with owners of the parent are recorded separately within equity.

(o) Research and Development

Research expenditure is recognised as an expense is incurred.

Costs incurred on developments projects (relating to the development and testing of new or improved 
products) are recognised as intangible assets when it is probable that the project will, after considering 
its commercial and technical feasibility, be completed and generate future economic benefits and its costs 
can be measured reliably. The expenditure capitalized comprises all directly attributable costs, including 
costs of materials, services, direct labour and an appropriate proportion of overheads. Other development 
expenditures that do not meet these criteria are recognized as an expense as incurred. Development costs 
previously recognised as an expense are not recognized as an asset in a subsequent period. Capitalised 
development costs are recorded as intangible assets and amortised from the point at which the asset is 
ready for use.

(p) Income Tax

Tax expense recognised in profit or loss comprises the sum of deferred tax and current tax not recognised 
in other comprehensive income or directly in equity. 

Current income tax assets and/or liabilities comprise those obligations to, or claims from, the Australian 
Taxation Office (ATO) and other fiscal authorities relating to the current or prior reporting periods that are 
unpaid at the reporting date. Current tax is payable on taxable profit, which differs from profit or loss in the 
financial statements. Calculation of current tax is based on tax rates and tax laws that have been enacted or 
substantively enacted by the end of the reporting period. 

Deferred income taxes are calculated using the full liability method on temporary differences between 
the carrying amounts of assets and liabilities and their tax bases. However, deferred tax is not provided 
on the initial recognition of goodwill or on the initial recognition of an asset or liability unless the related 
transaction is a business combination or affects tax or accounting profit. Deferred tax on temporary 
differences associated with investments in subsidiaries and joint ventures is not provided if reversal of these 
temporary differences can be controlled by the Group and it is probable that reversal will not occur in the 
foreseeable future. 

26

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continuedDeferred tax assets and liabilities are calculated, without discounting, at tax rates that are expected to 
apply to their respective period of realisation, provided they are enacted or substantively enacted by the 
end of the reporting period.

Deferred tax assets are recognised to the extent that it is probable that they will be able to be utilised 
against future taxable income, based on the Group’s forecast of future operating results which is adjusted 
for significant non-taxable income and expenses and specific limits to the use of any unused tax loss or 
credit. Deferred tax liabilities are always provided for in full. 

Deferred tax assets and liabilities are offset only when the Group has a right and intention to set off current 
tax assets and liabilities from the same taxation authority. 

Changes in deferred tax assets or liabilities are recognised as a component of tax income or expense in 
profit or loss, except where they relate to items that are recognised in other comprehensive income (such as 
the revaluation of land) or directly in equity, in which case the related deferred tax is also recognised in 
other comprehensive income or equity, respectively.

(q) Impairment of assets
Non-financial assets
At the end of each reporting period, non-financial assets are reviewed for impairment whenever events or 
changes in circumstances indicate that the carrying amount may not be recoverable. An impairment loss is 
recognised for the amount by which the asset’s carrying amount exceeds its recoverable amount.

Recoverable amount is the higher of an asset’s fair value less costs of disposal and value-in-use. The 
value-in-use is the present value of the estimated future cash flows relating to the asset using a pre-tax 
discount rate specific to the asset or cash-generating unit to which the asset belongs. Assets that do not 
have independent cash flows are grouped together to form a cash-generating unit.

Financial assets
At the end of each reporting period, the Group assesses whether there is objective evidence that a financial 
asset has been impaired. For financial assets measured at fair value, gains or losses will be recorded in profit 
or loss, or through Other Comprehensive Income (OCI) if the Group has made an irrevocable election at the 
time of initial recognition to account for equity instruments through OCI.

(r) Critical Accounting Estimates and Judgments Required

The Directors evaluate estimates and judgments incorporated into the financial report based on historical 
knowledge and best available current information. Estimates assume a reasonable expectation of future 
events and are based on current trends and economic data, obtained both externally and within the Group. 

Research and development expenditure
Distinguishing the research and development phases of a new customized project and determining whether 
the recognition requirements for the capitalization of development costs are met requires judgement. 
The Group has expensed all costs relating to research and development expenditure to date on the basis 
that the capitalisation requirements have not been met.

The Group’s consideration of whether its internal projects to develop drugs are in a research phase or 
development phase involves significant judgement.

27

ANNUAL REPORT 2023The Group considers a project to be in a development phase when the following can be demonstrated:

•  The technical feasibility of completing the intangible asset so that it will be available for use or sale;

•  There is intention to complete the project;

•  The existence of a market to be able to sell output resulting from the project;

•  How the intangible asset will generate probable future economic benefits;

•  There is adequate technical, financial and other resources available to complete the development and to 

use or sell the intangible asset; and

•  Expenditure attributable to the project can be reliably measured.

Share-based payment transactions
The Group measures the cost of equity-settled transactions by reference to the fair value of the equity 
instruments at the date at which they are granted. The fair value is determined using a Black-Scholes model. 

28

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continued4. OTHER INCOME

R&D Tax rebate

Interest income

2023 
$

459,085

797,083

1,256,168

2022 
$

182,251

79,881

262,132

5. LOSS FOR THE YEAR

The loss for the year before income tax includes the following specific expenses:

(a) Research and development expenses

Manufacturing expenses

Phase III Clinical Trial

Employee costs

Regulatory advice

Consultants

Scientific Advisory Board/Committees

COO costs

CSO - Executive director fees

Patent expenses

Total

(b) Administration expenses

Accounting and company secretarial fees

ASX, ASIC and bank fees

Executive Directors fees

Non-executive Directors fees

Legal fees

Rent and office expenses

Audit, corporate advice and tax fees

Travel and entertainment

Insurance

Investor relations and PR expenses

Share registry and shareholder meetings

Other general expenses

 Fx (gain)/losses

Website and IT expenses

Total 

2023 
$

2022 
$

743,560

3,847,049

292,842

—

1,789,049

—

311,687

299,421

116,883

326,498

762,449

509,892

189,548

714,836

1,094

—

315,373

142,907

7,400,491

2,962,596

148,227

52,623

180,000

160,000

30,769

28,238

60,914

102,913

176,597

112,368

23,536

10,247

26,738

11,822

1,124,992

131,759

69,597

138,750

160,000

109,120

20,980

68,100

30,891

92,004

51,116

20,122

13,703

(26,408)

20,432

900,286

29

ANNUAL REPORT 20236. INCOME TAX 

(a) The components of tax expense comprise:

Current tax 

Deferred tax expense

Total income tax expense from continuing operations 

Deferred income tax expense included in income tax expense 
comprises:

Decrease/(increase) in deferred tax assets

Decrease/(increase) in deferred tax liabilities

(b)  The prima facie tax on profit from ordinary activities before 
income tax is reconciliation of income tax expense to prima 
facie tax payable:

2023 
$

2022 
$

—

—

—

—

—

—

—

—

—

—

Loss before income tax

(7,749,856)

(3,953,140)

Prima facie tax benefit on loss from ordinary activities before 
income tax at 30% (2022: 30%)

(2,324,957)

(1,185,942)

Tax effect of:

– share-based payments

– intellectual property costs

– entertainment

– R&D consultants

– tax differential rate

Tax losses and temporary differences not recognised

Income tax expense/(benefit)

The applicable weighted average effective tax rate are as 
follows:

(c) Amounts recognised directly in equity

Aggregate current and deferred tax arising in the reporting 
period and not recognised in net loss or other comprehensive 
income but directly debited or credited to equity.

Current tax

Net deferred tax

30

144,162

134,661

3,651

99,597

703,698

1,239,188

—

0%

105,717

42,872

587

—

232,932

804,374

—

0%

—

—

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continued(d) Deferred tax assets

Patents

Accruals

Business related costs

Australian tax losses

Unrealised fx losses

Foreign tax losses

Capital raising costs in equity

7. CASH AND CASH EQUIVALENTS

Cash at bank and on hand

8. TRADE AND OTHER PAYABLES

Trade payables

Accruals and other payables

2023 
$

2022 
$

29,197

10,200

12,679

1,935,421

12,401

2,126,555

120,643

34,576

7,500

28,112

1,748,686

(7,922)

207,379

264,422

4,247,096

2,282,753

2023 
$

2022 
$

22,470,243

29,339,382

22,470,243

29,339,382

2023 
$

1,142,947

429,423

1,572,370

2022 
$

138,778

865,436

1,004,214

Trade payables are non-interest bearing and are normally settled on 30-day terms.

9. CONTRIBUTED EQUITY

2023  

$

2023 
Number 
of shares

2022  

$

2022 
Number 
of shares

Ordinary shares on issue – fully paid 

36,413,432

75,153,848

36,413,432

75,153,848

36,413,432

75,153,848

36,413,432

75,153,848

Holders of ordinary shares are entitled to receive dividends as declared from time to time and are entitled 
to one vote per share at shareholders meetings. In the event of winding up of the Company ordinary 
shareholders rank after creditors and are fully entitled to any proceeds of liquidation in proportion to the 
number and amount paid on the shares held. 

Movement in fully paid ordinary 
shares on issue

Balance at beginning of financial 
period

2023 
$

2023  
Number 
of shares

2022 
$

2022  
Number 
of shares

36,413,432

75,153,848

36,413,432

75,153,848

Balance at end of financial year

36,413,432

75,153,848

36,413,432

75,153,848

31

ANNUAL REPORT 202310. RESERVES

Share-based payment reserve

Foreign currency translation reserve

Nature and Purpose of Reserve

2023
$

2,379,171

18,143

2022
$

1,898,630

(1,727)

2,397,314

1,896,903

The share-based payment reserve records the value of options, performance rights and performance shares 
issued to the Group’s directors, employees, and third parties. The value of the amount disclosed during the 
period reflects the value of options, performance rights and performance shares issued by the Group. 

The Foreign currency translation reserve records exchange differences arising on translation of foreign 
controlled entities.

Options outstanding at 30 June 2023

The following options over ordinary shares of the Company were granted at reporting date:

Grant Date

Expiry Date

Exercise 
Price

Balance 
at start of 
year

Granted 
during the 
year

Exercised 
during the 
year

Forfeited 
during the 
year

Balance at 
year end

Vested and 
exercisable 
at year end

22 Nov 2019 22 Nov 2023

$0.60 2,200,000

21 Jan 2020 21 Jan 2023

$1.00 750,000

9 April 2020 9 April 2023

$0.60

60,000

20 Oct 2020 20 Oct 2023

$1.30 400,000

18 Nov 2020 18 Nov 2023

$1.30 800,000

8 April 2021 8 April 2024

$1.10 400,000

—

—

—

—

—

—

22 Nov 2022 1 Dec 2026

1 Dec 2022

1 Dec 2026

$0.87

$0.87

— 3,600,000

— 1,792,000

—

— 2,200,000 2,200,000

— 750,000

60,000

—

—

—

—

— 400,000

400,000

— 800,000

800,000

— 400,000

400,000

— 3,600,000

— 1,792,000

—

—

—

—

—

—

—

—

4,610,000 5,392,000

— 810,000 9,192,000 3,800,000

Reconciliation of movement in Share-based payment reserve:

Opening Balance - 1 July 2022

Share-based payment expense in respect to employee options on issue at 
30 June 2023

Share-based payment expense in respect to director options on issue at 
30 June 2023 

Share-based payment expense in respect to Director options on issue at 
30 June 2023

Number of 
Options

Value  

$

1,898,630

400,000

10,654

400,000

25,550

800,000

24,573

Share-based payment expense in respect to employee options on issue at 
30 June 2023 

1,792,000

145,631

Share-based payment expense in respect to Director options on issue at 
30 June 2023

Closing Balance – 30 June 2023

3,600,000

274,134

6,992,000

2,379,172

32

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continued11. LOSS PER SHARE

Basic and Diluted (Loss) per Share – cents

Total basic and diluted loss per share – cents

2023
$

(10.31)

2022
$

(5.26)

Basic and diluted loss per share is calculated by dividing the loss for the year attributable to ordinary equity 
holders of the parent by the weighted average number of ordinary shares outstanding during the year. 

The following table reflects the loss and share data used in the basic and diluted loss per share:

Net loss attributable to members of the Group

(7,749,856)

(3,953,140)

Earnings used in calculating basic and diluted earnings per share 
from continuing operations

(7,749,856)

(3,953,140)

2023
$

2022
$

2023
Number of 

shares

2022
Number of

shares

Weighted average number of Ordinary Shares used in calculating 
basic and diluted earnings per share

75,153,848

75,153,848

Dilutive Potential Ordinary Shares

As at balance date, there were no dilutive options on issue. 

Conversions, Calls, Subscriptions or Issues after 30 June 2023

Subsequent to year end there have not been any conversions, calls, subscriptions or issues of securities.

12. ACCUMULATED LOSSES

Accumulated losses at the beginning of the financial period

Net loss attributable to members of the Group

2023
$

2022
$

(9,829,452)

(7,749,856)

(5,876,312)

(3,953,140)

Accumulated losses at the end of the financial year

(17,579,308)

(9,829,452)

33

ANNUAL REPORT 202313.  RECONCILIATION OF NET CASH FLOWS OPERATING ACTIVITIES TO 

OPERATING (LOSS) AFTER TAX

Loss (after income tax) for the year

Non-cash items included in profit or loss:

Share-based payment expenses

Unrealised fx reserve movements

Net changes in working capital:

Increase in trade and other receivables

Increase in trade and other payables

Net cash used in operating activities

2023 
$

2022 
$

(7,749,856)

(3,953,140)

480,541

19,870

352,390

2,957

(187,852)

568,158

(124,517)

345,601

(6,869,139)

(3,376,709)

Non-cash investing and financing activities disclosed in other notes are:

Share-based payment expense (refer Note 17).

FX reserve movements (refer Note 10).

14. FINANCIAL RISK MANAGEMENT

The Group’s principal financial instruments comprise cash, short-term deposits and trade payables. 

The Group does not have any derivative instruments at 30 June 2023 and does not speculate in any 
financial instruments.

Financial Risks

The activities of the Group expose it primarily to the financial risks of interest rate risk, liquidity risk, foreign 
exchange risk and credit risk. The Board of Directors is responsible for monitoring and managing the 
financial risks of the Group. The Company Secretary/CFO monitors these risks by the review and analysis of 
monthly management accounts and other financial data.

Interest Rate Risk

The Group’s main interest rate risk arises from cash held on deposit by Australian Financial Institutions. 
Cash held in term deposits is subject to prevailing variable interest rates and expose the Group to cash flow 
interest rate risk. 

The following table summarises interest rate risk for the Group.

2023

Interest-bearing financial instruments

Cash and cash equivalents 

Fixed Interest 
Rate Maturing

Floating 
Interest 
Rate
$

1 Year or 
Less
$

1 to 5 Years
$

Non-
Interest 
Bearing
$

Total
$

22,470,243

22,470,243

—

—

—

—

— 22,470,243

— 22,470,243

34

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continued2022

Interest-bearing financial instruments

Cash and cash equivalents 

Fixed Interest 
Rate Maturing

Floating 
Interest 
Rate
$

1 Year or 
Less
$

1 to 5 Years
$

Non-
Interest 
Bearing
$

Total
$

29,339,382

29,339,382

—

—

—

—

— 29, 339,382

— 29,339,382

The Group does not rely on the generation of interest on cash at bank to provide working capital and does 
not consider the exposure to be material to the Group and have therefore not undertaken any further 
analysis of exposure.

Liquidity Risk

Liquidity risk is the risk that the Group will not be able to meet its financial obligations as they fall due. The 
Board of Directors manage liquidity risk by continually monitoring cash reserves and cashflow forecasts to 
ensure that financial commitments can be met as and when they fall due.

The Group’s objective is to maintain a balance between continuity of funding and flexibility through the use 
of equity funding. 

The following table details the expected contractual maturity for its non-derivative financial liabilities. 

2023 

Financial liabilities due

Trade and other payables

2022 

Financial liabilities due

Trade and other payables

Credit Risk Exposure

Total  

$

1 year or 
less 
$

1 – 5 years 
$

5+ years 
$

1,142,947

1,142,947

1,142,947

1,142,947

—

—

—

—

Total 
$

1 year or 
less 
$

1 – 5 years 
$

5+ years 
$

138,778

138,778

138,778

138,778

—

—

—

—

Credit risk is the risk of financial loss to the Group if a customer or counterparty to a financial instrument 
fails to meet its contractual obligations and arises principally from the Group’s cash at bank. The carrying 
amount of the financial assets on the Statement of Financial Position represents the maximum credit 
exposure. 

All cash and cash equivalents are held with large reputable financial institutions within Australia and 
therefore credit risk is considered minimal.

Cash and cash equivalents:

AA rated

2023 
$

2022 
$

22,470,243 29,339,382

35

ANNUAL REPORT 2023Foreign currency risk

The consolidated entity undertakes certain transactions denominated in foreign currency and is exposed to 
foreign currency risk through foreign exchange rate fluctuations.

Foreign exchange risk arises from future commercial transactions and recognised financial assets and 
financial liabilities denominated in a currency that is not the entity's functional currency. The risk is 
measured using sensitivity analysis and cash flow forecasting.

15. RELATED PARTY TRANSACTIONS 

Key Management Personnel

There were no key management personnel, other than the directors and the CFO/Company Secretary, 
during the year ended 30 June 2023.

The names of each person holding the position of director of the Company during the financial year are set 
out below:

•  Dr Jason Loveridge (resigned 10 July 2023)

•  Prof. Alexandra Sinclair (resigned 10 July 2023)

•  Dr Thomas Duthy

•  Dr Megan Baldwin

•  Mr David McAuliffe

•  Ms Narelle Warren

•  Ms Carol Parish

Transactions with key management personnel

(i)  Total key management personnel remuneration is as follows: 

Short Term Benefits

Other non-cash Benefits

Post-Employment Benefits

Share-based payments

2023 
$

2022 
$

1,229,562

966,468

—

55,038

—

467

462,338

281,315

1,746,938

1,248,250

(ii) Nil loans were payable to or receivable from KMPs during or at the end of the financial year.

Unless otherwise stated, none of the transactions incorporate special terms and conditions and no 
guarantees were given or received.

16. INTERESTS IN SUBSIDIARY

The consolidated financial statements incorporate the assets, liabilities and results of the following wholly-
owned subsidiary in accordance with the accounting policy described in note 3:

Name

Principal place of business /
Country of incorporation

Invex Therapeutics Ltd

United Kingdom

Ownership interest

2023
%

100

2022
%

100

36

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continued17. SHARE-BASED PAYMENTS

Share-based payments made during the year ended 30 June 2023 are summarised below. 

Recognised Share-based payment expense

Options granted to Directors as incentive

Options granted to Employees as incentive

2023  

$

324,256

156,285

2022  

$

281,315

71,075

480,541

352,390

Options granted to Directors and Employees for services 

The Group’s current Employee Share Option Plan (ESOP) was approved by Shareholders on 25 November 
2021. The previous Employee Share Option Plan (ESOP) was approved by the Board of Directors on 20 May 
2019 (“Incentive Plans”). The Incentive Plans are designed to provide medium and long term incentives 
for all employees (including Non-executive and Executive Directors) and to attract and retain experienced 
Employees, Board Members and Executive Officers and provide motivation to make the Group more 
successful. 

Under the previous ESOP, participants have been granted options which only vest if certain milestones 
are met. Participation in the plan is at the Board’s discretion and no individual has a contractual right to 
participate in the plan or to receive any guaranteed benefit.

Any option may only be exercised after the option has vested and other conditions imposed by the board 
have been satisfied. Options are granted under the ESOP for no consideration. Options granted under the 
ESOP carry no dividend or voting rights. When exercisable, shares allotted pursuant to the exercise of 
options will be allotted following receipt of relevant documentation and payments will rank equally with all 
other shares.

As options granted to employees and directors are considered to represent the value of the services 
received over the vesting period of the options, the assessed value of the options are recognised and 
expensed over the vesting period. Options vesting during the year of issue are fully expensed under the 
accounting standards. There were no new incentive securities granted during the financial year. The total 
Directors and Employee Options expense for the period is outlined below.

Valuation 

Tranche

Date Expiry Date

Exercise 
Price

Balance at 
start of year

Granted 
during the 
year

Vested at 
year end

Total  
Share-based 
payment 
expense for 
the year

1

2

3

4

5

6

Total

22 Nov 2019 22 Nov 2023

$0.60

2,200,000

— 2,200,000

20 Oct 2020 20 Oct 2023

18 Nov 2020 18 Nov 2023

8 April 2021 8 April 2024

22 Nov 2022

1 Dec 2026

1 Dec 2022

1 Dec 2026

$1.30

$1.30

$1.10

$0.87

$0.87

400,000

800,000

400,000

—

—

—

400,000

800,000

400,000

— 3,600,000

—

1,792,000

—

—

—

10,654

24,573

25,550

274,133

145,631

3,800,000

5,392,000

3,800,000

480,541

37

ANNUAL REPORT 2023Appropriate values for the options using the Black Scholes Model applying the following inputs.

Tranche

1

Exercise price

$0.60

Expected volatility

Expiry date (years)

Expected dividends

Risk free rate

Value per option

75%

4.00

Nil

0.77%

$0.42

2

$1.30

80%

3.00

Nil

0.77%

$0.35

3

$1.30

80%

3.00

Nil

0.87%

$0.32

4

$1.10

80%

3.00

Nil

0.77%

$0.33

5

$1.10

80%

3.00

Nil

0.77%

$0.33

6

7

$0.87

$0.87

60%

4.18

Nil

3.86%

$0.21

60%

4.00

Nil

3.86%

$0.23

The vesting conditions attached to the Tranche 1, 2, 3, 4 and 5 Director and Employee Options are as 
follows:

•  50% of the Options will vest and become exercisable upon completion of 12 months continuous service 

from date of issue; and

•  50% of the Options vest and become exercisable upon completion of 24 months continuous service 

from date of issue.

The vesting conditions attached to the Tranche 6 and 7 Director and Employee Options are as follows:

•  25% of the Options will vest and become exercisable upon completion of 12 months continuous service 

from date of issue; and

•  25% of the Options vest and become exercisable upon completion of 24 months continuous service from 

date of issue.

•  25% of the Options vest and become exercisable completion of recruitment for Phase III clinical trial.

•  25% of the Options vest upon completion at the phase 3 clinical trial read out.

The weighted average remaining contractual life of options outstanding at the end of the year was 1.51 
years.

18. MATTERS SUBSEQUENT TO END OF FINANCIAL YEAR

On the 10 July 2023 Dr Jason Loveridge and Professor Alexandra Sinclair resigned as Directors of the 
Company.

Other than as disclosed above, no matters or events have arisen since the end of the financial period 
which significantly affected or may significantly affect the operations of the company, the results of those 
operations or the state of affairs of the Company in subsequent financial periods. 

38

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continued19. PARENT ENTITY INFORMATION

Set out below is the supplementary information about the parent entity.

Statement of profit or loss and other comprehensive income

Loss after income tax

Total comprehensive income

Statement of financial position

Total current assets

Total non-current assets

Total current liabilities

Total liabilities

Equity

Issued capital

Reserves

Accumulated losses

Total equity

20. AUDITOR’S REMUNERATION

Amounts paid or payable to BDO for:

Audit services

 –  an audit or review of the financial report of the entity 

Total audit services

Corporate advisory services

Taxation services

Total other services

Parent

2023 
$

2022 
$

(7,160,991)

(4,692,091)

(7,160,991)

(4,692,091)

Parent

2023 
$

2022 
$

22,367,406

29,225,668

—

—

446,203

642,157

446,203

642,157

36,413,432

36,413,432

2,397,313

1,898,630

(16,889,542)

(9,728,551)

21,921,203

28,583,511

2023 
$

2022 
$

42,414

42,414

2,500

4,000

6,500

37,376

37,376

2,000

5,658

7,658

39

ANNUAL REPORT 202321. DIVIDENDS

There are no dividends paid or payable at 30 June 2023.

22. COMMITMENTS

There are no other commitments which require disclosure as at 30 June 2023 (30 June 2022: nil).

23. SEGMENT REPORTING

The Group has identified its operating segments based on the internal reports that are reviewed and used 
by the Board of Directors in assessing performance and determining the allocation of resources.

The Group is managed primarily on the basis of its research and development activities. Operating 
segments are therefore determined on the same basis.

Reportable segments disclosed are based on aggregating operating segments where the segments are 
considered to have similar economic characteristics.

The Group operated in one segment which is research and development activities within Australia. The 
Company is domiciled in Australia.

24. CONTINGENT LIABILITIES AND CONTINGENT ASSETS

The Directors are not aware of any contingent liabilities or contingent assets which require disclosure as at 
30 June 2023 (30 June 2022 : nil).

40

INVEX THERAPEUTICS LTD.Notes to the Consolidated Financial Statements continuedDirectors’ Declaration

In the Directors’ opinion:

(a)  the financial statements and notes are in accordance with the Corporations Act 2001, and:

(i)  complying with Accounting Standards, the Corporations Regulations 2001 and other mandatory 

professional reporting requirements; and

(ii)  give a true and fair view of the financial position as at 30 June 2023 and of the performance for the 

year ended on that date of the Group.

(iii)  are in accordance with International Financial Reporting Standards issued by the International 

Accounting Standards Board, as stated in note 1 to the financial statements; and

(b)  In the Directors’ opinion, there are reasonable grounds to believe that the Group will be able to pay its 

debts as and when they become due and payable; and

(c)  The Directors have been given the declarations by the Executive Director as required by section 295A, of 

the Corporations Act 2001.

This declaration is made in accordance with a resolution of the Board of Directors and is signed for and on 
behalf of the Directors by;

David McAuliffe
Interim Non-executive Chairman

Perth, Western Australia, 17 August 2023

41

ANNUAL REPORT 2023Independent Auditor’s Report

Tel: +61 8 6382 4600 
Fax: +61 8 6382 4601 
www.bdo.com.au 

Level 9, Mia Yellagonga Tower 2  
5 Spring Street  
Perth, WA 6000 
PO Box 700 West Perth WA 6872 
Australia 

INDEPENDENT AUDITOR'S REPORT 

To the members of Invex Therapeutics Ltd 

Report on the Audit of the Financial Report 

Opinion  

We have audited the financial report of Invex Therapeutics Ltd (the Company) and its subsidiary (the 
Group), which comprises the consolidated statement of financial position as at 30 June 2023, the 
consolidated statement of profit or loss and other comprehensive income, the consolidated statement 
of changes in equity and the consolidated statement of cash flows for the year then ended, and notes 
to the financial report, including a summary of significant accounting policies and the directors’ 
declaration. 

In our opinion the accompanying financial report of the Group, is in accordance with the Corporations 
Act 2001, including:  

(i) 

Giving a true and fair view of the Group’s financial position as at 30 June 2023 and of its 
financial performance for the year ended on that date; and  

(ii) 

Complying with Australian Accounting Standards and the Corporations Regulations 2001.  

Basis for opinion  

We conducted our audit in accordance with Australian Auditing Standards.  Our responsibilities under 
those standards are further described in the Auditor’s responsibilities for the audit of the Financial 
Report section of our report.  We are independent of the Group in accordance with the Corporations 
Act 2001 and the ethical requirements of the Accounting Professional and Ethical Standards Board’s 
APES 110 Code of Ethics for Professional Accountants (including Independence Standards) (the Code) 
that are relevant to our audit of the financial report in Australia.  We have also fulfilled our other 
ethical responsibilities in accordance with the Code. 

We confirm that the independence declaration required by the Corporations Act 2001, which has been 
given to the directors of the Company, would be in the same terms if given to the directors as at the 
time of this auditor’s report. 

We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis 
for our opinion.  

Key audit matters 

Key audit matters are those matters that, in our professional judgement, were of most significance in 
our audit of the financial report of the current period.  These matters were addressed in the context of 
our audit of the financial report as a whole, and in forming our opinion thereon, and we do not provide 
a separate opinion on these matters.  

BDO Audit (WA) Pty Ltd ABN 79 112 284 787 is a member of a national association of independent entities which are all members of BDO Australia 
Ltd ABN 77 050 110 275, an Australian company limited by guarantee. BDO Audit (WA) Pty Ltd and BDO Australia Ltd are members of BDO 
International Ltd, a UK company limited by guarantee, and form part of the international BDO network of independent member firms. Liability 
limited by a scheme approved under Professional Standards Legislation. 

42

INVEX THERAPEUTICS LTD. 
 
 
 
 
Valuation of Share-Based Payments 

Key Audit Matter 

How the matter was addressed in our audit 

During the year ended 30 June 2023, the 
Company issued options to key management 
personnel (“KMP”) and employees.  

As a result of the risk identified, for all share-
based payment arrangements during the year we 
performed the following: 

These instruments constitute share-based 
payments in accordance with AASB 2 and 
accordingly are required to be recognised at 
their fair value and expensed over the 
respective vesting (performance) period. In 
addition, arrangements from prior financial 
periods continue to vest and impact the current 
year financial statements.  

Refer to notes 1(m), 1(r) and 17 of the financial 
report for a description of the accounting 
policy and key assumptions and inputs applied 
to determine the valuation of these options. 

Given the complexities and significant 
judgements involved under the applicable 
accounting standard we consider the 
accounting for the share-based payment 
expense to be a key audit matter.  

• 

• 

• 

• 

• 

• 

Reviewed the relevant agreements to 
obtain an understanding of the contractual 
nature and terms and conditions of the 
share-based payment arrangements;  

Reviewed management’s determination of 
the fair value of the share-based payments 
granted, considering the appropriateness 
of the valuation models used and assessing 
the valuation inputs;  

Engaged our valuation specialists to assess 
the reasonableness of management’s 
valuation inputs, specifically the volatility 
rate adopted; 

Verified the share-based payment expense 
has been recognised appropriately over 
the relevant vesting period;  

Reviewed the reasonableness of 
management’s probability assessments 
applied to the non-market based 
performance conditions compared to 
relevant internal and external factors; and 

Reviewed the adequacy of the financial 
report disclosures, including the 
Remuneration Report and related party 
disclosures.  

43

ANNUAL REPORT 2023 
 
 
 
 
 
Independent Auditor’s Report continued

Other information  

The directors are responsible for the other information.  The other information comprises the 
information in the Group’s annual report for the year ended 30 June 2023, but does not include the 
financial report and the auditor’s report thereon.  

Our opinion on the financial report does not cover the other information and we do not express any 
form of assurance conclusion thereon.  

In connection with our audit of the financial report, our responsibility is to read the other information 
and, in doing so, consider whether the other information is materially inconsistent with the financial 
report or our knowledge obtained in the audit or otherwise appears to be materially misstated.  

If, based on the work we have performed, we conclude that there is a material misstatement of this 
other information, we are required to report that fact.  We have nothing to report in this regard.  

Responsibilities of the directors for the Financial Report  

The directors of the Company are responsible for the preparation of the financial report that gives a 
true and fair view in accordance with Australian Accounting Standards and the Corporations Act 2001 
and for such internal control as the directors determine is necessary to enable the preparation of the 
financial report that gives a true and fair view and is free from material misstatement, whether due to 
fraud or error. 

In preparing the financial report, the directors are responsible for assessing the ability of the group to 
continue as a going concern, disclosing, as applicable, matters related to going concern and using the 
going concern basis of accounting unless the directors either intend to liquidate the Group or to cease 
operations, or has no realistic alternative but to do so.  

Auditor’s responsibilities for the audit of the Financial Report  

Our objectives are to obtain reasonable assurance about whether the financial report as a whole is free 
from material misstatement, whether due to fraud or error, and to issue an auditor’s report that 
includes our opinion.  Reasonable assurance is a high level of assurance, but is not a guarantee that an 
audit conducted in accordance with the Australian Auditing Standards will always detect a material 
misstatement when it exists.  Misstatements can arise from fraud or error and are considered material 
if, individually or in the aggregate, they could reasonably be expected to influence the economic 
decisions of users taken on the basis of this financial report.  

A further description of our responsibilities for the audit of the financial report is located at the 
Auditing and Assurance Standards Board website (http://www.auasb.gov.au/Home.aspx) at: 
https://www.auasb.gov.au/admin/file/content102/c3/ar1_2020.pdf. This description forms part of 
our auditor’s report. 

44

INVEX THERAPEUTICS LTD. 
 
 
Report on the Remuneration Report 

Opinion on the Remuneration Report  

We have audited the Remuneration Report included in pages 10 to 17 of the directors’ report for the 
year ended 30 June 2023. 

In our opinion, the Remuneration Report of Invex Therapeutics Ltd, for the year ended 30 June 2023, 
complies with section 300A of the Corporations Act 2001.  

Responsibilities 

The directors of the Company are responsible for the preparation and presentation of the 
Remuneration Report in accordance with section 300A of the Corporations Act 2001.  Our responsibility 
is to express an opinion on the Remuneration Report, based on our audit conducted in accordance with 
Australian Auditing Standards.  

BDO Audit (WA) Pty Ltd 

Jarrad Prue 

Director 

Perth 

17 August 2023 

45

ANNUAL REPORT 2023 
 
 
 
Corporate Governance Statement

In fulfilling its obligations and responsibilities to its various stakeholders, the Board is a strong advocate 
of corporate governance. This statement outlines the principal corporate governance procedures of Invex 
Therapeutics Ltd (Group). The Board of Directors (Board) supports a system of corporate governance to 
ensure that the management of Invex Therapeutics Ltd is conducted to maximise shareholder wealth in a 
proper and ethical manner.

ASX CORPORATE GOVERNANCE COUNCIL RECOMMENDATIONS

The Board has adopted corporate governance policies and practices consistent with the ASX Corporate 
Governance Council's Principles of Good Corporate Governance and Best Practice Recommendations ("ASX 
Principles and Recommendations 4th Edition") where considered appropriate for Invex Therapeutics Ltd 
size and nature. Such policies include, but are not limited to the Board Charter, Board Committee Charters, 
Code of Conduct, Trading in Securities, Continuous Disclosure, Shareholder Communication and Risk 
Management Policies.

Further details in respect to the Group’s corporate governance practises and copies of Group’s corporate 
governance policies and the 2023 Corporate Governance Statement, approved by the Board and applicable 
as at 30 June 2023 are available of the Group’s website:

https://invextherapeutics.com/corporate-governance/ 

46

INVEX THERAPEUTICS LTD.ASX Additional Information

Additional information required by the ASX Limited Listing Rules not disclosed elsewhere in this Annual 
Report is set out below.

1. SHAREHOLDINGS

The issued capital of the Company as at 1 August 2023 is 75,153,848 ordinary fully paid shares. All issued 
ordinary fully paid shares carry one vote per share.

Ordinary Shares

Shares Range

1-1,000

1,001-5,000

5,001-10,000

10,001-100,000

100,001 and above

Total

Unmarketable parcels

Holders

Units

208

478

237

461

101

124,047

1,324,037

1,888,313

17,128,540

54,688,911

%

0.17

1.76

2.51

22.79

72.77

1,485

75,153,848

100.00

There were 479 holders of less than a marketable parcel of ordinary shares representing a total of 
626,704 shares.

2. TOP 20 SHAREHOLDERS AS AT 1 AUGUST 2023

Name

1 TATTARANG

2 TISIA NOMINEES PTY LTD 

3 MR JASON LOVERIDGE

4 MR DAVID JERIMIAH MCAULIFFE

5 JK NOMINEES PTY LTD 

6 PROF ALEXANDRA JEAN SINCLAIR

7 MRS KATHRYN SALKIlLD

8 THE UNIVERSITY OF BIRMINGHAM

Number of 
shares

8,846,154

3,725,000

3,374,462

3,350,001

3,000,000

2,500,000

2,293,000

2,000,000

9 BANNABY INVESTMENTS PTY LIMITED

1,625,000

10 SUNSET CAPITAL MANAGEMENT PTY LTD

11 ANTHONY GRIST

12 CITYSCAPE ASSET PTY LTD

13 CABLETIME PTY LTD 

14 SANDHURST TRUSTEES LTD

15 PALLA NOMINEES PTY LTD 

16 ARDROY SECURITIES PTY LTD 17 ENDLESS SUMMER (WA) PTY LTD 18 MS SOPHIE ALICE LOVERIDGE 19 PETER KYROS PTY LTD 20 WEBINVEST PTY LTD TOP 20 TOTAL TOTAL REMAINING HOLDERS BALANCE TOTAL 1,448,175 1,338,518 1,150,000 1,120,000 1,081,924 580,000 550,407 550,000 493,000 470,075 375,000 % 11.77 4.96 4.49 4.46 3.99 3.33 3.05 2.66 2.16 1.93 1.78 1.53 1.49 1.44 0.77 0.73 0.73 0.66 0.63 0.50 39,870,716 53.05 35,283,132 46.95 75,153,848 100.00 47 ANNUAL REPORT 2023 3. UNQUOTED SECURITIES The unlisted options over shares in the Company as at 1 August 2023 are as follows: Holder DR JASON LOVERIDGE ALEXANDRA JEAN SINCLAIR CIPA INVESTMENTS PTY LTD DR MEGAN BALDWIN CAROL PARISH PHILUCHNA PTY LTD DAVID JERIMIAH MCAULIFFE EMMA HILTON Total 4. VOTING RIGHTS See note 12 of the financial statements. 5. SUBSTANTIAL SHAREHOLDERS AS AT 1 AUGUST 2023 Holder TATTARANG Number of options held % of issued capital held 2,080,000 1,920,000 1,800,000 600,000 1,520,000 848,000 200,000 224,000 22.63 20.89 19.58 6.53 16.53 9.23 2.17 2.44 9,192,000 100.00 Number of shares held % of issued capital held 8,846,154 11.77 6. RESTRICTED SECURITIES SUBJECT TO ESCROW PERIOD There are no restricted securities. 7. ON-MARKET BUYBACK There is currently no on-market buyback program for any of Invex’s listed securities. 8. COMPANY CASH AND ASSETS In accordance with Listing Rule 4.10.19, the Company confirms that it has been using the cash and assets it had acquired at the time of admission and for the year ended 30 June 2023 in a way that is consistent with its business objective and strategy. 48 INVEX THERAPEUTICS LTD. Corporate Directory This financial report includes the consolidated financial statements and notes of the Group consisting of Invex Therapeutics Ltd and its controlled entity (Invex Therapeutics UK). The Group’s functional and presentation currency is Australian Dollars ($). A description of the Group’s operations and principal activity is included in the review of operations and activities in the Directors’ report on pages 6 to 18. The Directors’ Report is not part of the Consolidated Financial Report. Directors: Dr Thomas Duthy Dr Megan Baldwin Mr David McAuliffe Dr Jason Loveridge (resigned 10 July 2023) Professor Alexandra Sinclair (resigned 10 July 2023) Company Secretary: Ms Narelle Warren Registered Office & Principal Place of Business: Level 2, 38 Rowland St Perth WA 6008 Tel: + 61 8 6382 0137 Website: www.invextherapeutics.com Auditors: BDO Audit (WA) Pty Ltd Level 9 Mia Yellagonga Tower 2 5 Spring Street Perth WA 6000 Bankers: Westpac Banking Corporation Level 4 Tower 2 Brookfield Place 123 St Georges Terrace Perth WA 6000 Solicitors: Steinepreis Paganin Level 4, The Read Buildings 16 Milligan St Perth WA 6000 Share Registry: Automic Registry Services Telephone: 1300 288 664 International: +61 2 9698 5414 Website: www.automicgroup.com.au ASX code: IXC ideate Co. iii ANNUAL REPORT 2023