Oramed Pharmaceuticals Inc.
Annual Report 2017

Plain-text annual report

UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended August 31, 2017 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 000-50298 ORAMED PHARMACEUTICALS INC.(Exact Name of Registrant as Specified in its Charter) Delaware 98-0376008(State or Other Jurisdiction of Incorporation or Organization) (I.R.S. Employer Identification No.) Hi-Tech Park 2/4Givat-RamP.O. Box 39098Jerusalem, Israel 91390(Address of Principal Executive Offices) (Zip Code) +972-2-566-0001(Registrant’s Telephone Number, Including Area Code) Securities registered pursuant to Section 12(b) of the Exchange Act: None Securities registered pursuant to Section 12(g) of the Act: Common Stock, $.012 par value per share Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ☐ No ☒ Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filingrequirements for the past 90 days. Yes ☒ No ☐ Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Date Filerequired to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorterperiod that the registrant was required to submit and post such files). Yes ☒ No ☐ Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained,to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendmentto this Form 10-K. ☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company oran emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and "emerging growthcompany" in Rule 12b-2 of the Exchange Act. Large accelerated filer ☐ Accelerated filer ☐Non-accelerated filer ☐ Smaller reporting company ☒(Do not check if a smaller reporting company) Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying withany new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☒ The aggregate market value of the voting and non-voting common equity held by non-affiliates as of the last business day of the registrant’s mostrecently completed second fiscal quarter was $56,748,843, based on a price of $6.05, being the last price at which the shares of the registrant’s common stockwere sold on The Nasdaq Capital Market prior to the end of the most recently completed second fiscal quarter. Indicate the number of shares outstanding of each of the registrant’s classes of common stock, as of the latest practicable date: 14,306,100 shares ofcommon stock issued and outstanding as of November 28, 2017.  ORAMED PHARMACEUTICALS INC. FORM 10-K(FOR THE FISCAL YEAR ENDED AUGUST 31, 2017) TABLE OF CONTENTS PART I1 ITEM 1. BUSINESS.1 ITEM 1A. RISK FACTORS.15 ITEM IB. UNRESOLVED STAFF COMMENTS.24 ITEM 2. PROPERTIES.24 ITEM 3. LEGAL PROCEEDINGS.24 ITEM 4. MINE SAFETY DISCLOSURES.24PART II25 ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASESOF EQUITY SECURITIES.25 ITEM 6. SELECTED FINANCIAL DATA.26 ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.27 ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.33 ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.34 ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE.34 ITEM 9A. CONTROLS AND PROCEDURES.34 ITEM 9B. OTHER INFORMATION.34PART III35 ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE.35 ITEM 11. EXECUTIVE COMPENSATION.39 ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDERMATTERS.50 ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE.52 ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES.53PART IV54 ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES.54 ITEM 16. FORM 10-K SUMMARY.58  As used in this Annual Report on Form 10-K, the terms “we,” “us,” “our,” the “Company,” and “Oramed” mean Oramed Pharmaceuticals Inc. and ourwholly-owned Israeli subsidiary, Oramed Ltd., unless otherwise indicated. All dollar amounts refer to U.S. dollars unless otherwise indicated. On August 31, 2017, the exchange rate between the New Israeli Shekel, or NIS, and the dollar, as quoted by the Bank of Israel, was NIS 3.596 to$1.00. Unless indicated otherwise by the context, statements in this Annual Report on Form 10-K that provide the dollar equivalent of NIS amounts orprovide the NIS equivalent of dollar amounts are based on such exchange rate. CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS The statements contained in this Annual Report on Form 10-K that are not historical facts are “forward-looking statements” within the meaning ofthe Private Securities Litigation Reform Act of 1995 and other federal securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “plannedexpenditures,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements, butare not deemed to represent an all-inclusive means of identifying forward-looking statements as denoted in this Annual Report on Form 10-K. Additionally,statements concerning future matters are forward-looking statements. We remind readers that forward-looking statements are merely predictions and thereforeinherently subject to uncertainties and other factors and involve known and unknown risks that could cause the actual results, performance, levels of activity,or our achievements, or industry results, to be materially different from any future results, performance, levels of activity, or our achievements, or industryresults, expressed or implied by such forward-looking statements. Such forward-looking statements appear in Item 1 - “Business” and Item 7 - “Management'sDiscussion and Analysis of Financial Condition and Results of Operations,” as well as elsewhere in this Annual Report on Form 10-K and include, amongother statements, statements regarding the following: ●the expected development and potential benefits from our products in treating diabetes;●the prospects of entering into additional license agreements, or other partnerships or forms of cooperation with other companies or medicalinstitutions;●future milestones, conditions and royalties under the license agreement with Hefei Tianhui Incubator of Technologies Co., Ltd., or HTIT;●our research and development plans, including pre-clinical and clinical trials plans and the timing of enrollment, obtaining results and conclusion oftrials, including without limitation, our expectation that we will initiate two six-month Phase III clinical trials if our Phase IIb three-month dosingclinical trial is successful, and our expectation to file a New Drug Application thereafter;●our belief that our technology has the potential to deliver medications and vaccines orally that today can only be delivered via injection;●the competitive ability of our technology based product efficacy, safety, patient convenience, reliability, value and patent position;●the potential market demand for our products;●our expectation that in the upcoming year our research and development expenses, net, will continue to be our major expenditure;●our expectations regarding our short- and long-term capital requirements;●our outlook for the coming months and future periods, including but not limited to our expectations regarding future revenue and expenses; and●information with respect to any other plans and strategies for our business. Although forward-looking statements in this Annual Report on Form 10-K reflect the good faith judgment of our management, such statements canonly be based on facts and factors currently known by us. Consequently, forward-looking statements are inherently subject to risks and uncertainties andactual results and outcomes may differ materially from the results and outcomes discussed in or anticipated by the forward-looking statements. Factors thatcould cause or contribute to such differences in results and outcomes include, without limitation, those discussed herein, including those risks described inItem 1A. "Risk Factors", and expressed from time to time in our other filings with the Securities and Exchange Commission, or SEC. In addition, historicresults of scientific research, clinical and preclinical trials do not guarantee that the conclusions of future research or trials would not suggest differentconclusions. Also, historic results referred to in this Annual Report on Form 10-K could be interpreted differently in light of additional research, clinical andpreclinical trials results. Readers are urged not to place undue reliance on these forward-looking statements, which speak only as of the date of this AnnualReport on Form 10-K. Except as required by law, we undertake no obligation to revise or update any forward-looking statements in order to reflect any eventor circumstance that may arise after the date of this Annual Report on Form 10-K. Readers are urged to carefully review and consider the various disclosuresmade throughout the entirety of this Annual Report on Form 10-K which attempt to advise interested parties of the risks and factors that may affect ourbusiness, financial condition, results of operations and prospects.  PART I ITEM 1. BUSINESS. DESCRIPTION OF BUSINESS Research and Development We are a pharmaceutical company currently engaged in the research and development of innovative pharmaceutical solutions, including an oralinsulin capsule to be used for the treatment of individuals with diabetes, and the use of orally ingestible capsules or pills for delivery of other polypeptides. Oral insulin: We are seeking to revolutionize the treatment of diabetes through our proprietary flagship product, an orally ingestible insulin capsule,or ORMD-0801. In August 2017, we had a call with the U.S. Food and Drug Administration, or FDA, regarding ORMD-0801. During the call, the FDAadvised that the regulatory pathway for the submission of ORMD-0801 would be a Biologics License Application, or BLA. Such a pathway would grant us12 years of marketing exclusivity for ORMD-0801, if approved, and an additional six months of exclusivity may be granted to us if the product also receivesapproval for use in pediatric patients. We plan to initiate in the first quarter of calendar year 2018, a clamp study on six type 1 diabetic patients and a three-month dose-ranging clinical trial on approximately 240 type 2 diabetic patients to assess the safety and evaluate the effect of ORMD-0801 on HbA1c, themain FDA registrational endpoint. In February 2017, we completed a Phase IIa dose finding clinical trial which was initiated in October 2016 in order tobetter define the optimal dosing of ORMD-0801. In April 2016, we completed a Phase IIb clinical trial on 180 type 2 adult diabetic patients that was initiatedin June 2015 and conducted in 33 sites in the United States. This double-blind, randomized, 28-day dosing clinical trial was conducted under anInvestigational New Drug application, or IND, with the FDA. The clinical trial, designed to assess the safety and efficacy of ORMD-0801, investigatedORMD-0801 over a 28 day treatment period and had statistical power to give us greater insight into the drug’s efficacy. The trial indicated a statisticallysignificant lowering of blood glucose levels versus placebo across several endpoints, with no serious or severe adverse issues related to the drug. The trialsuccessfully met all of its primary and most of its secondary and exploratory endpoints for both safety and efficacy. Prior to that trial, we completed Phase IIaclinical trials in patients with both type 1 and type 2 diabetes. Our technology allows insulin to travel from the gastrointestinal tract via the portal vein to thebloodstream, revolutionizing the manner in which insulin is delivered. It enables its passage in a more physiological manner than current delivery methods ofinsulin. Our technology is a platform that has the potential to deliver medications and vaccines orally that today can only be delivered via injection. Oral Glucagon-like peptide-1: Glucagon-like peptide-1, or GLP-1, is an incretin hormone, which is a type of gastrointestinal hormone thatstimulates the secretion of insulin from the pancreas. The incretin concept was hypothesized when it was noted that glucose ingested by mouth (oral)stimulated two to three times more insulin release than the same amount of glucose administered intravenously. In addition to stimulating insulin release,GLP-1 was found to suppress glucagon release (a hormone involved in the regulation of glucose) from the pancreas, slow gastric emptying to reduce the rateof absorption of nutrients into the blood stream, and increase satiety. Other important beneficial attributes of GLP-1 are its effects of increasing the number ofbeta cells (cells that manufacture and release insulin) in the pancreas and, possibly, protection of the heart. In addition to our flagship product, the ORMD-0801 insulin capsule, we are using our technology for an orally ingestible GLP-1 capsule, or ORMD-0901. In August 2015, we began a non-FDA clinical trialoutside of the United States for our oral exenatide capsule on type 2 diabetic patients. The trial was completed during the second quarter of calendar year2016 and indicated positive results as it showed ORMD-0901 to be safe and well tolerated and also demonstrated encouraging efficacy data. We completed athree-month pre-clinical toxicology study in March 2017, anticipate receiving the final report during the fourth quarter of calendar year 2017 and expect tofile an IND and move directly into a pharmacokinetics study, followed by a large Phase II trial in the United States under an FDA IND. Diabetes: Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that causes sugar to be absorbedinto cells, where the sugar is converted into energy needed for daily life. The cause of diabetes is attributed both to genetics (type 1 diabetes) and, most often,to environmental factors such as obesity and lack of exercise (type 2 diabetes). According to the International Diabetes Federation, or IDF, an estimated 415million adults worldwide suffered from diabetes in 2015 and the IDF projects this number will increase to 642 million by 2040. Also, according to the IDF, in2015, an estimated 5.3 million people died from diabetes. According to the American Diabetes Association, or ADA, in the United States there wereapproximately 30.3 million people with diabetes, or 9.4% of the United States population in 2015. Diabetes is a leading cause of blindness, kidney failure,heart attack, stroke and amputation. 1  Intellectual property: We own a portfolio of patents and patent applications covering our technologies, and we are aggressively protecting thesetechnology developments on a worldwide basis. Management: We are led by a highly-experienced management team knowledgeable in the treatment of diabetes. Our Chief Scientific Officer,Miriam Kidron, PhD, is a world-recognized pharmacologist and a biochemist and the innovator primarily responsible for our oral insulin technologydevelopment and know-how. Scientific Advisory Board: Our management team has access to our internationally recognized Scientific Advisory Board whose members arethought-leaders in their respective areas. The Scientific Advisory Board is comprised of Dr. Roy Eldor, Professor Ele Ferrannini, Professor Avram Hershko, Dr.Harold Jacob and Dr. Harvey L. Katzeff. Strategy Short Term Business Strategy We plan to conduct further research and development on the technology covered by the patent application “Methods and Composition for OralAdministration of Proteins,” which we acquired from Hadasit Medical Research Services and Development Ltd. in 2006, and which is granted in variousforeign jurisdictions, as well as the other patents we have filed in various foreign jurisdictions since then, as discussed below under “—Patents and Licenses”and below under “Item 1A. Risk Factors”. Through our research and development efforts, we have successfully developed an oral dosage form that will withstand the harsh environment of thestomach and intestines and will be effective in delivering active insulin or other proteins, such as exenatide, for the treatment of diabetes. The excipients thatare added to the proteins in the formulation process must not modify the proteins chemically or biologically, and the dosage form must be safe to ingest. Weplan to continue to conduct clinical trials to show the effectiveness of our technology. We originally filed an IND with the FDA in December 2012 forclearance to begin a Phase II clinical trial of our oral insulin capsule, ORMD-0801, in order to evaluate the safety, tolerability and efficacy in type 2 diabeticvolunteers. Because the identical formulation of ORMD-0801 had not yet been studied in humans at bedtime, in February 2013, the FDA noted concernsabout mitigating potential risks of severe hypoglycemia and requested that we perform a sub-study in a controlled in-patient setting for a one-week periodprior to beginning the larger multi-centered Phase II trial. As a result, we withdrew the original IND and, in April 2013, we submitted a new IND for the PhaseIIa study. Following the FDA’s clearance to proceed in May 2013, we began the Phase IIa study in July 2013. As we announced in January 2014, the Phase IIastudy met all primary and secondary endpoints. Specifically, the Phase IIa study evaluated the pharmacodynamic effects of ORMD-0801 on mean nighttimeglucose (determined using a continuous glucose monitor). The results showed that ORMD-0801 exhibited a sound safety profile, led to reduced meandaytime and nighttime glucose readings and lowered fasting blood glucose concentrations, when compared to placebo. In addition, no serious adverse eventsoccurred during this study, and the only adverse events that occurred were not drug related. In light of these results, in June 2015, we initiated the Phase IIb clinical trial on 180 type 2 adult diabetic patients which was completed in April2016. This double-blind, randomized, 28-day dosing clinical trial was designed to assess the safety and efficacy of ORMD-0801, and was conducted in 33sites in the United States. The trial indicated a statistically significant lowering of blood glucose levels versus placebo across several endpoints, with noserious or severe adverse issues related to the drug. The trial successfully met all of its primary and most of its secondary and exploratory endpoints. The trialprimarily evaluated the nighttime glucose lowering effect and safety of ORMD-0801 compared to a placebo. The results of the mean nighttime glucoseshowed a significant difference in mean change from run-in versus placebo. ORMD-0801 oral insulin was safe and well-tolerated for the dosing regimen inthis trial. The trial further evaluated the effect of ORMD-0801 on mean 24-hour glucose, fasting glucose, and daytime glucose and the results showed astatistically significant difference in mean change from run-in versus placebo. Two examples of the data gleaned from this study are shown below: 2  * Indicates Statistically Significant Difference from Placebo (p-Value<0.05) No significant difference was shown in change in morning fasting serum insulin, C-Peptide, or triglycerides. Following the significant results of the Phase IIb trial, we initiated in October 2016 an additional Phase IIa dose finding clinical trial which wascompleted in February 2017. This randomized, double-blind trial was conducted on 32 type 2 adult diabetic patients in order to better define the optimaldosing of ORMD-0801 moving forward. The results of the trial indicated a positive safety profile and potentially meaningful efficacy of ORMD-0801, as theefficacy data suggest ORMD-0801 improves glucose control. In March 2017, we initiated a six-month toxicology study to allow for the use of our oral insulin capsule for a longer period than previouslyperformed, in preparation for our proposed upcoming three-month clinical trial for type 2. We anticipate receiving the final report of this study in the firstquarter of calendar year 2018. In August 2017, we had a call with the FDA regarding ORMD-0801. During the call, the FDA advised that the regulatory pathway for submission ofORMD-0801 would be a BLA. Such a pathway would grant a full 12 years of marketing exclusivity for ORMD-0801, if approved. On top of this, anadditional six months of exclusivity may be granted if the product also receives approval for use in pediatric patients. The FDA confirmed that the approachto nonclinical toxicology, chemistry manufacturing controls and qualification of excipients would be driven by their published guidance documents. Weplan to initiate in the first quarter of calendar year 2018 a three-month dose-ranging clinical trial on approximately 240 type 2 diabetes patients to assess thesafety and evaluate the effect of ORMD-0801 on HbA1c, the main FDA registrational endpoint. In addition, the FDA confirmed our ability to use insulin fromdifferent suppliers in a Phase III study. In February 2014, we submitted a protocol to the FDA to initiate a Phase IIa trial of our oral insulin capsule for type 1 diabetes volunteers. Theprotocol was submitted under our existing IND to include both type 1 and type 2 diabetes indications. Beginning in March 2014, the double-blind,randomized, placebo controlled, seven-day treatment study design was carried out at an inpatient setting on 25 type 1 diabetic patients. As we announced inOctober 2014, the results showed that ORMD-0801 oral insulin given before meals appeared to be safe and well-tolerated for the dosing regimen in thisstudy. Although the study was not powered to show statistical significance, there were internally consistent trends observed. Consistent with the timing ofadministration, the data showed a decrease in bolus insulin, a decrease in post-prandial glucose, a decrease in daytime glucose by continual glucosemonitoring and an increase in post-prandial hypoglycemia in the active group, demonstrating the efficacy of ORMD-0801. 3  We also plan to conduct a glucose clamp study of our oral insulin capsule on six type 1 diabetic patients in the first quarter of calendar year 2018.The glucose clamp is a method for quantifying insulin absorption in order to measure a patient’s insulin sensitivity and how well a patient metabolizesglucose. Should our Phase IIb three-month dosing clinical trial successfully meet its primary endpoints, we anticipate initiating two six-month Phase IIIclinical trials on both type 1 and type 2 diabetic patients, following which we expect to file a New Drug Application with a potential approval by the thirdquarter of calendar year 2023. In September 2013, we submitted a pre-IND package to the FDA for ORMD-0901. In August 2015, we began a non-FDA clinical trial outside of theUnited States on type 2 diabetic patients. The trial was completed during the second quarter of calendar year 2016 and indicated positive results as it showedORMD-0901 to be safe and well tolerated and demonstrated encouraging efficacy data. We completed a three-month pre-clinical toxicology study in March2017 and anticipate receiving the final report during the fourth quarter of calendar year 2017. We expect to file an IND during the first quarter of calendaryear 2018 and move directly into a small pharmacokinetics study followed by a large Phase II trial in the United States under an FDA IND. Clinical trials are planned in order to substantiate our results as well as for purposes of making future filings for drug approval. We also plan toconduct further research and development by deploying our proprietary drug delivery technology for the delivery of other polypeptides in addition toinsulin, and to develop other innovative pharmaceutical products. The table below gives an overview of our primary product pipeline (calendar quarters): Phase IPhase IIPhase IIITimelineORMD-0801oral insulinType 2 diabetesQ1 ’14: Phase IIa completedQ2 ’16: Phase IIb multi-center study completedQ1 ’17: Phase IIa - dose finding study completedQ1 ’18: Phase IIb 90-day multi-center study projectedinitiation (projected completion Q2 ’19)Q4 ’19: Phase III study projected initiation (projectedcompletion Q2 ’21) Type 1 diabetes Q3 ’14: Phase IIa study completedQ1 ’18: Clamp study projected initiation (projectedcompletion Q3 ’18)Q4 ’19: Phase III projected initiation (projectedcompletion Q2 ’21) ORMD-0901oral GLP-1Type 2 diabetes Q2 ’16: Phase Ib non-US study completedQ1 ’18: Pharmacokinetics clinical study projected initiation(projected completion Q3 ’18)H2 ’18: Phase II projected initiation (projected completionQ4 ’19) 4  Another component of our business strategy is to partner with other companies or medical institutions in order to further develop our technologyand commence pre-commercialization activities. On November 30, 2015, we, our Israeli subsidiary and HTIT entered into a Technology License Agreement,which was further amended, according to which we granted HTIT an exclusive commercialization license in the territory of the People's Republic of China,Macau and Hong Kong, or the Territory, related to our oral insulin capsule, ORMD-0801. Pursuant to this license agreement, HTIT will conduct, at its ownexpense, certain pre-commercialization and regulatory activities with respect to our technology related to the ORMD-0801 capsule, and will pay certainroyalties and an aggregate of approximately $37.5 million (see “Out-Licensed Technology” below). We plan to seek additional partnerships or forms ofcooperation with other companies or medical institutions. While our strategy is to partner with an appropriate party, no assurance can be given that we will infact be able to reach an agreeable partnership with any third party. Under certain circumstances, we may determine to develop one or more of our oral dosageforms on our own, either world-wide or in select territories. Long Term Business Strategy If our oral insulin capsule or other drug delivery solutions show significant promise in clinical trials, we plan to ultimately seek a strategiccommercial partner, or partners, with extensive experience in the development, commercialization, and marketing of insulin applications and/or other orallydigestible drugs. We anticipate such partner or partners would be responsible for, or substantially support, late stage clinical trials (Phase III) to increase thelikelihood of obtaining regulatory approvals and registrations in the appropriate markets in a timely manner. We further anticipate that such partner, orpartners, would also be responsible for sales, marketing and support of our oral insulin capsule in these markets. Such planned strategic partnership, orpartnerships, may provide a marketing and sales infrastructure for our products as well as financial and operational support for global clinical trials, postmarketing studies, label expansions and other regulatory requirements concerning future clinical development in the United States and elsewhere. Any futurestrategic partner, or partners, may also provide capital and expertise that would enable the partnership to develop new oral dosage forms for otherpolypeptides. While our strategy is to partner with an appropriate party, no assurance can be given that we will in fact be able to reach an agreeablepartnership with any third party. Under certain circumstances, we may determine to develop one or more of our oral dosage forms on our own, either world-wide or in select territories. Other Planned Strategic Activities In addition to developing our own oral dosage form drug portfolio, we are, on an on-going basis, considering in-licensing and other means ofobtaining additional technologies to complement and/or expand our current product portfolio. Our goal is to create a well-balanced product portfolio thatwill enhance and complement our existing drug portfolio. Product Development Research and Development Summary We devote the majority of our efforts to research and development, including clinical studies for our lead clinical product candidates, as describedbelow. Orally Ingestible Insulin During the fiscal year ended August 31, 2007, we conducted several clinical studies of our orally ingestible insulin that were intended to assess boththe safety/tolerability and absorption properties of our proprietary oral insulin. Based on the pharmacokinetic and pharmacologic outcomes of these trials, wedecided to continue the development of our oral insulin product. During the fiscal year ended August 31, 2008, we successfully completed animal studies and non-FDA approved clinical trials using our oral insulincapsule, including a Phase Ib clinical trial in healthy human volunteers with the intent of dose optimization; a Phase IIa study to evaluate the safety andefficacy of our oral insulin capsule in type 2 diabetic volunteers at Hadassah Medical Center in Jerusalem; and a Phase IIa study to evaluate the safety andefficacy of our oral insulin capsule on type 1 diabetic volunteers. 5  Our successful non-FDA clinical trials continued in the fiscal year ended August 31, 2009, or fiscal 2009, with a Phase IIb study in South Africa toevaluate the safety, tolerability and efficacy of our oral insulin capsule on type 2 diabetic volunteers. In September 2010, we reported the successful results of an exploratory clinical trial testing the effectiveness of our oral insulin capsule in type 1diabetes patients suffering from uncontrolled diabetes. Unstable or labile diabetes is characterized by recurrent, unpredictable and dramatic blood glucoseswings often linked with irregular hyperglycemia and sometimes serious hypoglycemia affecting type 1 diabetes patients. This successfully completedexploratory study was a proof of concept study for defining a novel indication for ORMD-0801. We believe the encouraging results justify further clinicaldevelopment of ORMD-0801 capsule application toward management of uncontrolled diabetes. In March 2011, we reported that we successfully completed a comprehensive toxicity study for our oral insulin capsule. The study was completedunder conditions prescribed by the FDA Good Laboratory Practices regulations. We began FDA-approved clinical trials of ORMD-0801 in July 2013, with the Phase IIa study, which evaluated the pharmacodynamic effects ofORMD-0801 on mean nighttime glucose (determined using a continuous glucose monitor) on 30 volunteers with type 2 diabetes. As we announced inJanuary 2014, the results showed that ORMD-0801 exhibited a sound safety profile, led to reduced mean daytime and nighttime glucose readings andlowered fasting blood glucose concentrations, when compared to placebo. In March 2014, we began an FDA-approved Phase IIa trial of ORMD-0801 in volunteers with type 1 diabetes. As we announced in October 2014, theresults showed that ORMD-0801 oral insulin given before meals appeared to be safe and well-tolerated for the dosing regimen in this study. Although thestudy was not powered to show statistical significance, there were internally consistent trends observed. Consistent with the timing of administration, the datashowed a decrease in bolus insulin, a decrease in post-prandial glucose, a decrease in daytime glucose by continual glucose monitoring and an increase inpost-prandial hypoglycemia in the active group, demonstrating the efficacy of ORMD-0801. In June 2015, we initiated a Phase IIb clinical trial on 180 type 2 adult diabetic patients, which was completed in April 2016. This double-blind,randomized, 28-day dosing clinical trial was designed to assess the safety and efficacy of ORMD-0801 and was conducted in 33 sites in the United States.The trial indicated a statistically significant lowering of blood glucose levels versus placebo across several endpoints, with no serious or severe adverseissues related to the drug. The trial successfully met all of its primary and most of its secondary and exploratory endpoints for both safety and efficacy. In October 2016, we initiated an additional Phase IIa, dose finding clinical trial which was completed in February 2017. This randomized, double-blind trial was conducted on 32 type 2 adult diabetic patients in order to better define the optimal dosing of ORMD-0801 moving forward. The results of thetrial indicated a positive safety profile and potentially meaningful efficacy of ORMD-0801, as the efficacy data suggest ORMD-0801 improves glucosecontrol. In March 2017, we initiated a six-month toxicology study to allow for the use of our oral insulin capsule for a longer period than previouslyperformed, in preparation for our proposed upcoming three-month clinical trial for type 2 diabetes. We anticipate receiving the final report of this study in thefirst quarter of calendar year 2018. In August 2017, we had a call with the FDA regarding ORMD-0801. During the call, the FDA advised that the regulatory pathway for submission ofORMD-0801 would be a BLA. Such a pathway would grant a full 12 years of marketing exclusivity for ORMD-0801, if approved, and an additional sixmonths of exclusivity may be granted to us if the product also receives approval for use in pediatric patients. We plan to initiate in the first quarter ofcalendar year 2018 a three-month dose-ranging clinical trial on approximately 240 type 2 diabetes patients to assess the safety and evaluate the effect ofORMD-0801 on HbA1c, the main FDA registrational endpoint. We utilize Clinical Research Organizations, or CROs, to conduct our clinical studies. 6  GLP-1 Analog During fiscal 2009, we completed pre-clinical trials of ORMD-0901, an analog for GLP-1, which suggested that the GLP-1 analog (exenatide-4),when combined with Oramed’s capsule technology, is absorbed through the gastrointestinal tract and retains its biological activity. In December 2009, we completed non-FDA approved clinical trial in healthy, male volunteers conducted at Hadassah University Medical Center inJerusalem. This study evaluated the safety and efficacy of ORMD-0901. The results of the study indicated that ORMD-0901 was well tolerated by all subjectsand demonstrated physiological activity, as extrapolated from ensuing subject insulin levels when compared to those observed after treatment with placebo. In January 2013, we began a clinical trial for our oral exenatide capsule on healthy volunteers and type 2 diabetic patients. Based on this study, wedecided to make slight adjustments in the manufacturing of these capsules and have begun pre-toxicology studies on the new capsules. In September 2013, we submitted a pre-IND package to the FDA for ORMD-0901. In August 2015, we began a non-FDA clinical trial outside of the United States for ORMD-0901 on type 2 diabetic patients. The trial was completedduring the second quarter of calendar year 2016 and indicated positive results as it showed ORMD-0901 to be safe and well tolerated and also demonstratedencouraging efficacy data. We completed a three-month toxicology study in March 2017 and anticipate receiving the final report during the fourth quarter of calendar year2017 and expect to file an IND and move directly into a pharmacokinetics study followed by a large Phase II trial in the United States under an FDA IND. Combination Therapy In June 2012, we presented an abstract, which reported the impact of our oral insulin capsule, ORMD-0801, delivered in combination with our oralexenatide capsule ORMD-0901. The work assessed the safety and effectiveness of a combination of oral insulin and oral exenatide treatments delivered topigs prior to food intake. The drug combination resulted in significantly improved blood glucose regulation when compared to administration of each drugseparately. In the near term, we are focusing our efforts on the development of our flagship products, oral insulin and oral exenatide. Once these two productshave progressed further in clinical trials, we intend to conduct additional studies with the oral combination therapy. Feasibility study In August 2015, we entered into an agreement with a large international pharmaceutical company, or the Pharma Company, pursuant to which weconducted a feasibility study, using one of the Pharma Company's propriety injectable compounds. The study used our proprietary technology in order todeliver the compound orally. Following the successful completion of the first stage of the study in July 2016, we continued to the second step of the study.The study will provide data required for decision making on whether to enter into a license agreement between the parties. Other products During the first quarter of calendar 2017, we began developing a new drug candidate, a weight loss treatment in the form of an oral leptin capsule,and in April 2017, Israel’s Ministry of Health approved our commencement of a proof of concept single dose study for our oral leptin drug candidate toevaluate its pharmacokinetic and pharmacodynamics (glucagon reduction) in 10 type 1 adult diabetic patients. The study is projected to initiate in calendaryear 2018 and be completed during calendar year 2019. In November 2017, Israel’s Ministry of Health approved us to initiate an exploratory clinical study of our oral insulin capsule, ORMD-0801, inpatients with nonalcoholic steatohepatitis (NASH). The proposed three-month treatment study will assess the effectiveness of ORMD-0801 in reducing liverfat content, inflammation and fibrosis in patients with NASH. We expect to initiate the study during the end of calendar year 2017 and complete it duringcalendar year 2019. 7  Raw Materials Our oral insulin capsule is currently manufactured by Swiss Caps AG. One of our oral capsule ingredients is being developed and produced by an Indian company. In July 2010, Oramed Ltd. entered into the Manufacturing and Supply Agreement, or MSA, with Sanofi-Aventis Deutschland GMBH, or Sanofi-Aventis. According to the MSA, Sanofi-Aventis will supply Oramed Ltd. with specified quantities of recombinant human insulin to be used for clinical trials. We purchase, pursuant to separate agreements with third parties, the raw materials required for the manufacturing of our oral capsule. We generallydepend upon a limited number of suppliers for the raw materials. Although alternative sources of supply for these materials are generally available, we couldincur significant costs and disruptions if we would need to change suppliers. The termination of our relationships with our suppliers or the failure of thesesuppliers to meet our requirements for raw materials on a timely and cost-effective basis could have a material adverse effect on our business, prospects,financial condition and results of operations. Patents and Licenses We maintain a proactive intellectual property strategy, which includes patent filings in multiple jurisdictions, including the United States and othercommercially significant markets. We hold 26 patent applications currently pending, with respect to various compositions, methods of production and oraladministration of proteins and exenatide. Expiration dates for pending patents, if granted, will fall between 2026 and 2034. We hold 64 patents, seventeen of which were issued in fiscal 2017, fifteen of which were issued in September 2017 and two of which were allowed inEurope and Canada, including patents issued by the United States, Swiss, German, French, U.K., Italian, Dutch, Spanish, Australian, Israeli, Japanese, NewZealand, South African, Russian, Canadian, Hong Kong, Chinese, European and Indian patent offices that cover a part of our technology, which allows forthe oral delivery of proteins; patents issued by the Australian, European, Austrian, Belgian, French, German, Irish, Italian, Luxembourg , Monaco, Dutch,Norwegian, Spanish, Swedish, Swiss, U.K., Israeli, New Zealand, South African and Russian patent offices that cover part of our technology for the oraldelivery of exenatide; and patents issued by the European, Austrian, Belgian, Danish, French, German, Irish, Italian, Luxembourg , Monaco, Netherland,Norway, Spanish, Swedish, Swiss, U.K. and Japanese patent offices for treating diabetes. Consistent with our strategy to seek protection in key markets worldwide, we have been and will continue to pursue the patent applications andcorresponding foreign counterparts of such applications. We believe that our success will depend on our ability to obtain patent protection for ourintellectual property. Our patent strategy is as follows: ●Aggressively protect all current and future technological developments to assure strong and broad protection by filing patents and/orcontinuations in part as appropriate, ●Protect technological developments at various levels, in a complementary manner, including the base technology, as well as specificapplications of the technology, and ●Establish comprehensive coverage in the United States and in all relevant foreign markets in anticipation of future commercializationopportunities. We also rely on trade secrets and unpatentable know-how that we seek to protect, in part, by confidentiality agreements. Our policy is to require ouremployees, consultants, contractors, manufacturers, outside scientific collaborators and sponsored researchers, our board of directors, or our Board, technicalreview board and other advisors, to execute confidentiality agreements upon the commencement of employment or consulting relationships with us. Theseagreements provide that all confidential information developed or made known to the individual during the course of the individual’s relationship with us isto be kept confidential and not disclosed to third parties except in specific limited circumstances. We also require signed confidentiality or material transferagreements from any company that is to receive our confidential information. In the case of employees, consultants and contractors, the agreements providethat all inventions conceived by the individual while rendering services to us shall be assigned to us as the exclusive property of our Company. There can beno assurance, however, that all persons who we desire to sign such agreements will sign, or if they do, that these agreements will not be breached, that wewould have adequate remedies for any breach, or that our trade secrets or unpatentable know-how will not otherwise become known or be independentlydeveloped by competitors. 8  Out-Licensed Technology In June 2010, Oramed Ltd. entered into a joint venture agreement with D.N.A Biomedical Solutions Ltd., or D.N.A, for the establishment of EnteraBio LTD, or Entera. Under the terms of a license agreement that was entered into between Oramed Ltd. and Entera in August 2010, we out-licensed technology to Entera,on an exclusive basis, for the development of oral delivery drugs for certain indications to be agreed upon between the parties. The out-licensed technologydiffers from our main delivery technology that is used for oral insulin and GLP-1 analog and is subject to different patent applications. Entera’s initialdevelopment effort is for an oral formulation for the treatment of osteoporosis. In March 2011, we entered into a patent transfer agreement to replace theoriginal license agreement upon closing pursuant to which Oramed Ltd. assigned to Entera all of its right, title and interest in and to the patent applicationthat it had licensed to Entera in August 2010. Under this agreement, Oramed Ltd. is entitled to receive from Entera royalties of 3% of Entera’s net revenues (asdefined in the agreement) and a license back of that patent application for use in respect of diabetes and influenza. In March 2011, we also consummated a transaction with D.N.A, whereby we sold to D.N.A 47% of Entera’s outstanding share capital on an undilutedbasis, retaining a 3% interest as of March 2011. In consideration for the shares sold to D.N.A, the Company received, among other payments, 4,202,334ordinary shares of D.N.A The D.N.A ordinary shares are traded on the Tel Aviv Stock Exchange and have a quoted price, which is subject to market fluctuations, and may, attimes, have a price below the value on the date we acquired such shares. In addition, the ordinary shares of D.N.A have historically experienced low tradingvolume; as a result, there is no guarantee that we will be able to resell the ordinary shares of D.N.A at the prevailing market prices. During the years endedAugust 31, 2017, 2016 and 2015, we did not sell any of the D.N.A ordinary shares. As of August 31, 2017, we held approximately 7.9% of D.N.A’soutstanding ordinary shares. In November 2017, Entera filed with the SEC a draft registration statement on Form F-1 for the initial public offering by Entera, a listing of its shareson the Nasdaq and for potential resale by certain selling stockholders of Entera's ordinary shares previously issued. In June 2016, Entera announced that it had obtained orphan status from the European Medicines Agency, or EMA, for its oral treatment forhypoparathyroidism. EMA approval is in addition to the orphan status it obtained from the FDA for the same oral treatment in April 2014. In July 2015, Entera announced it had completed a phase IIa study to assess the safety and efficacy of its oral treatment for hypoparathyroidism andthat the goals of the study were achieved. On November 30, 2015, we, our Israeli subsidiary and HTIT entered into a Technology License Agreement, and on December 21, 2015 these partiesentered into an Amended and Restated Technology License Agreement that was further amended by the parties on June 3, 2016 and July 24, 2016, or theLicense Agreement. According to the License Agreement, we granted HTIT an exclusive commercialization license in the Territory, related to our oral insulincapsule, ORMD-0801, or the Product. Pursuant to the License Agreement, HTIT will conduct, at its own expense, certain pre-commercialization andregulatory activities with respect to our technology and ORMD-0801 capsule, and will pay (i) royalties of 10% on net sales of the related commercializedproducts to be sold by HTIT in the Territory, or Royalties, and (ii) an aggregate of $37.5 million, of which $3 million is payable immediately, $8 million willbe paid subject to our entry into certain agreements with certain third parties, and $26.5 million will be payable upon achievement of certain milestones andconditions. In the event that we will not meet certain conditions, the Royalties rate may be reduced to a minimum of 8%. Following the final expiration ofour patents covering the technology in the Territory in 2033, the Royalties rate may be reduced, under certain circumstances, to 5%. 9  The royalty payment obligation shall apply during the period of time beginning upon the first commercial sale of the Product in the Territory, andending upon the later of (i) the expiration of the last-to-expire licensed patents in the Territory; and (ii) 15 years after the first commercial sale of the Productin the Territory, or the Royalty Term. The License Agreement shall remain in effect until the expiration of the Royalty Term. The License Agreement contains customary terminationprovisions. The initial payment of $3 million was received in January 2016. Following the achievement of certain milestones, the second and third milestonepayments of $6.5 million and $4 million, respectively, were received in July 2016 and the fourth milestone payment of $4 million was received in October2016. We also entered into a separate securities purchase agreement with HTIT, or the SPA, pursuant to which HTIT invested $12 million in us in December2015 (see – “Liquidity and capital resources” below). In connection with the License Agreement and the SPA, we received a non-refundable payment of$500,000 as a no-shop fee. Government Regulation The Drug Development Process Regulatory requirements for the approval of new drugs vary from one country to another. In order to obtain approval to market our drug portfolio, weneed to go through a different regulatory process in each country in which we apply for such approval. In some cases information gathered during theapproval process in one country can be used as supporting information for the approval process in another country. As a strategic decision, we decided to firstexplore the FDA regulatory pathway. The following is a summary of the FDA’s requirements. The FDA requires that pharmaceutical and certain other therapeutic products undergo significant clinical experimentation and clinical testing priorto their marketing or introduction to the general public. Clinical testing, known as clinical trials or clinical studies, is either conducted internally by lifescience, pharmaceutical, or biotechnology companies or is conducted on behalf of these companies by CROs. The process of conducting clinical studies is highly regulated by the FDA, as well as by other governmental and professional bodies. Below wedescribe the principal framework in which clinical studies are conducted, as well as describe a number of the parties involved in these studies. Protocols. Before commencing human clinical studies, the sponsor of a new drug or therapeutic product must submit an IND application to the FDA.The application contains, among other documents, what is known in the industry as a protocol. A protocol is the blueprint for each drug study. The protocolsets forth, among other things, the following: ●Who must be recruited as qualified participants, ●How often to administer the drug or product, ●What tests to perform on the participants, and ●What dosage of the drug or amount of the product to give to the participants. Institutional Review Board. An institutional review board is an independent committee of professionals and lay persons which reviews clinicalresearch studies involving human beings and is required to adhere to guidelines issued by the FDA. The institutional review board does not report to theFDA, but its records are audited by the FDA. Its members are not appointed by the FDA. All clinical studies must be approved by an institutional reviewboard. The institutional review board’s role is to protect the rights of the participants in the clinical studies. It approves the protocols to be used, theadvertisements which the company or CRO conducting the study proposes to use to recruit participants, and the form of consent which the participants willbe required to sign prior to their participation in the clinical studies. 10  Clinical Trials. Human clinical studies or testing of a potential product are generally done in three stages known as Phase I through Phase III testing.The names of the phases are derived from the regulations of the FDA. Generally, there are multiple studies conducted in each phase. Phase I. Phase I studies involve testing a drug or product on a limited number of healthy or patient participants, typically 24 to 100 people at a time.Phase I studies determine a product’s basic safety and how the product is absorbed by, and eliminated from, the body. This phase lasts an average of sixmonths to a year. Phase II. Phase II trials involve testing of no more than 300 participants at a time who may suffer from the targeted disease or condition. Phase IItesting typically lasts an average of one to two years. In Phase II, the drug is tested to determine its safety and effectiveness for treating a specific illness orcondition. Phase II testing also involves determining acceptable dosage levels of the drug. Phase II studies may be split into Phase IIa and Phase IIb sub-studies. Phase IIa studies may be conducted with patient volunteers and are exploratory (non-pivotal) studies, typically designed to evaluate clinical efficacyor biological activity. Phase IIb studies are conducted with patients defined to evaluate definite dose range and evaluate efficacy. If Phase II studies show thata new drug has an acceptable range of safety risks and probable effectiveness, a company will generally continue to review the substance in Phase III studies. Phase III. Phase III studies involve testing large numbers of participants, typically several hundred to several thousand persons. The purpose is toverify effectiveness and long-term safety on a large scale. These studies generally last two to three years. Phase III studies are conducted at multiple locationsor sites. Like the other phases, Phase III requires the site to keep detailed records of data collected and procedures performed. Biological License Application. The results of the clinical trials for a biological product are submitted to the FDA as part of a BLA. Following thecompletion of Phase III studies, assuming the sponsor of a potential product in the United States believes it has sufficient information to support the safetyand effectiveness of its product, the sponsor will generally submit a BLA to the FDA requesting that the product be approved for marketing. The applicationis a comprehensive, multi-volume filing that includes the results of all clinical studies, information about the drug’s composition, and the sponsor’s plans forproducing, packaging and labeling the product. The FDA’s review of an application can take a few months to many years, with the average review lasting 18months. Once approved, drugs and other products may be marketed in the United States, subject to any conditions imposed by the FDA. Approval of a BLAprovides 12 years of exclusivity in the U.S. market. Phase IV. The FDA may require that the sponsor conduct additional clinical trials following new drug approval. The purpose of these trials, knownas Phase IV studies, is to monitor long-term risks and benefits, study different dosage levels or evaluate safety and effectiveness. In recent years, the FDA hasincreased its reliance on these trials. Phase IV studies usually involve thousands of participants. Phase IV studies also may be initiated by the companysponsoring the new drug to gain broader market value for an approved drug. Similar to the U.S., a European sponsor of a biological product may submit a Marketing Approval Application to the EMA for the registration of theproduct. The approval process in Europe consists of several stages, which together are summed up to 210 days from the time of submission of the application(net, without periods in which the sponsor provides answers to questions raised by the agency) following which, a Marketing Approval may be granted.During the approval process, the sponsor's manufacturing facilities will be audited in order to assess Good Manufacturing Practice compliance. The drug approval process is time-consuming, involves substantial expenditures of resources, and depends upon a number of factors, including theseverity of the illness in question, the availability of alternative treatments, and the risks and benefits demonstrated in the clinical trials. 11  Other Regulations Various federal, state and local laws, regulations, and recommendations relating to safe working conditions, laboratory practices, the experimentaluse of animals, the environment and the purchase, storage, movement, import, export, use, and disposal of hazardous or potentially hazardous substances,including radioactive compounds and infectious disease agents, used in connection with our research are applicable to our activities. They include, amongothers, the U.S. Atomic Energy Act, the Clean Air Act, the Clean Water Act, the Occupational Safety and Health Act, the National Environmental Policy Act,the Toxic Substances Control Act, and Resources Conservation and Recovery Act, national restrictions on technology transfer, import, export, and customsregulations, and other present and possible future local, state, or federal regulation. The compliance with these and other laws, regulations andrecommendations can be time-consuming and involve substantial costs. In addition, the extent of governmental regulation which might result from futurelegislation or administrative action cannot be accurately predicted and may have a material adverse effect on our business, financial condition, results ofoperations and prospects. Competition Competition in General Competition in the area of biomedical and pharmaceutical research and development is intense and significantly depends on scientific andtechnological factors. These factors include the availability of patent and other protection for technology and products, the ability to commercializetechnological developments and the ability to obtain regulatory approval for testing, manufacturing and marketing. Our competitors include majorpharmaceutical, medical products, chemical and specialized biotechnology companies, many of which have financial, technical and marketing resourcessignificantly greater than ours. In addition, many biotechnology companies have formed collaborations with large, established companies to supportresearch, development and commercialization of products that may be competitive with ours. Academic institutions, governmental agencies and other publicand private research organizations are also conducting research activities and seeking patent protection and may commercialize products on their own orthrough joint ventures. We are aware of certain other products manufactured or under development by competitors that are used for the treatment of thediseases and health conditions that we have targeted for product development. We can provide no assurance that developments by others will not render ourtechnology obsolete or noncompetitive, that we will be able to keep pace with new technological developments or that our technology will be able tosupplant established products and methodologies in the therapeutic areas that are targeted by us. The foregoing factors could have a material adverse effecton our business, prospects, financial condition and results of operations. These companies, as well as academic institutions, governmental agencies andprivate research organizations, also compete with us in recruiting and retaining highly qualified scientific personnel and consultants. Competition within our sector is increasing, so we will encounter competition from existing firms that offer competitive solutions in diabetestreatment solutions. These competitive companies could develop products that are superior to, or have greater market acceptance, than the products beingdeveloped by us. We will have to compete against other biotechnology and pharmaceutical companies with greater market recognition and greater financial,marketing and other resources. Our competition will be determined in part by the potential indications for which our technology is developed and ultimately approved byregulatory authorities. In addition, the first product to reach the market in a therapeutic or preventive area is often at a significant competitive advantagerelative to later entrants to the market. Accordingly, the relative speed with which we, or our potential corporate partners, can develop products, complete theclinical trials and approval processes and supply commercial quantities of the products to the market are expected to be important competitive factors. Ourcompetitive position will also depend on our ability to attract and retain qualified scientific and other personnel, develop effective proprietary products,develop and implement production and marketing plans, obtain and maintain patent protection and secure adequate capital resources. We expect ourtechnology, if approved for sale, to compete primarily on the basis of product efficacy, safety, patient convenience, reliability, value and patent position. Competition for Our Oral Insulin Capsule We anticipate the oral insulin capsule to be a competitive diabetes drug because of its anticipated efficacy and safety profile. The following aretreatment options for type 1 and type 2 diabetic patients: ●Insulin injections, ●Insulin pumps, or ●A combination of diet, exercise and oral medication which improve the body’s response to insulin or cause the body to produce moreinsulin. Several entities who are actively developing oral insulin capsules and/or alternatives to insulin are thought to be: Diabetology (UK), BioconLimited (India) and Midatech (UK). 12  Scientific Advisory Board We maintain a Scientific Advisory Board consisting of internationally recognized scientists who advise us on scientific and technical aspects of ourbusiness. The Scientific Advisory Board meets periodically to review specific projects and to assess the value of new technologies and developments to us. Inaddition, individual members of the Scientific Advisory Board meet with us periodically to provide advice in their particular areas of expertise. TheScientific Advisory Board consists of the following members, information with respect to whom is set forth below: Dr. Roy Eldor, Professor Ele Ferrannini,Professor Avram Hershko, Dr. Harold Jacob and Dr. Harvey L. Katzeff. Dr. Roy Eldor, MD, joined the Oramed Scientific Advisory Board in July 2016. He is an endocrinologist, internist and researcher with over twentyyears of clinical and scientific experience. He is currently Director of the Diabetes Unit at the Institute of Endocrinology, Metabolism & Hypertension, Tel-Aviv Sourasky Medical Center. Prior to that, Dr. Eldor served as Principal Scientist at Merck Research Laboratories, Clinical Research - Diabetes &Endocrinology, Rahway, New Jersey. He has previously served as a senior physician in internal medicine at the Diabetes Unit in Hadassah Hebrew UniversityHospital, Jerusalem, Israel; and the Diabetes Division at the University of Texas Health Science Center in San Antonio, Texas (under the guidance of Dr. R.A.DeFronzo). Dr. Eldor is a recognized expert, with over 35 peer reviewed papers and book chapters, and has been a guest speaker at numerous internationalforums. Professor Ele Ferrannini, MD, joined the Oramed Scientific Advisory Board in February 2007. He is a past President to the European Associationfor the Study of Diabetes, which supports scientists, physicians and students from all over the world who are interested in diabetes and related subjects inEurope, and performs functions similar to that of the ADA in the United States. Professor Ferrannini has worked with various institutions including theDepartment of Clinical & Experimental Medicine, University of Pisa School of Medicine, and CNR (National Research Council) Institute of ClinicalPhysiology, Pisa, Italy; and the Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, Texas. He has alsohad extensive training in internal medicine and endocrinology, and has specialized in diabetes studies. Professor Ferrannini has received a Certificate of theEducational Council for Foreign Medical Graduates from the University of Bologna, and with cum laude honors completed a subspecialty in Diabetes andMetabolic Diseases at the University of Torino. He has published over 500 original papers and 50 book chapters and he is a “highly cited researcher,”according to the Institute for Scientific Information. Professor Avram Hershko, MD, PhD, joined the Oramed Scientific Advisory Board in July 2008. He earned his MD degree (1965) and PhD degree(1969) from the Hebrew University-Hadassah Medical School of Jerusalem. Professor Hershko served as a physician in the Israel Defense Forces from 1965 to1967. After a post-doctoral fellowship with Gordon Tomkins at the University of San Francisco (1969-72), he joined the faculty of the Haifa Technionbecoming a professor in 1980. He is now Distinguished Professor in the Unit of Biochemistry in the B. Rappaport Faculty of Medicine of the Technion.Professor Hershko’s main research interests concern the mechanisms by which cellular proteins are degraded, a formerly neglected field of study. ProfessorHershko and his colleagues showed that cellular proteins are degraded by a highly selective proteolytic system. This system tags proteins for destruction bylinkage to a protein called ubiquitin, which had previously been identified in many tissues, but whose function was previously unknown. Subsequent workby Professor Hershko and many other laboratories has shown that the ubiquitin system has a vital role in controlling a wide range of cellular processes, suchas the regulation of cell division, signal transduction and DNA repair. Professor Hershko was awarded the Nobel Prize in Chemistry (2004) jointly with hisformer PhD student Aaron Ciechanover and their colleague Irwin Rose. His many honors include the Israel Prize for Biochemistry (1994), the Gairdner Award(1999), the Lasker Prize for Basic Medical Research (2000), the Wolf Prize for Medicine (2001) and the Louisa Gross Horwitz Award (2001). ProfessorHershko is a member of the Israel Academy of Sciences (2000) and a Foreign Associate of the U.S. Academy of Sciences (2003). 13  Dr. Harold Jacob, MD, joined the Oramed Scientific Advisory Board in November 2016. Since 1998, Dr. Jacob has served as the president ofMedical Instrument Development Inc., a company which provides a range of support and consulting services to start-up and early stage companies as well aspatenting its own proprietary medical devices. Since 2011, Dr. Jacob has also served as an attending physician at Hadassah University Medical Center, wherehe has served as the director of the gastrointestinal endoscopy unit since September 2013. Dr. Jacob has advised a spectrum of companies in the past and heserved as a consultant and then as the Director of Medical Affairs at Given Imaging Ltd., from 1997 to 2003, a company that developed the first swallowablewireless pill camera for inspection of the intestine. He has licensed patents to a number of companies including Kimberly-Clark Corporation. Since 2014, Dr.Jacob has served as the Chief Medical Officer and a director of NanoVibronix, Inc., a medical device company using surface acoustics to prevent catheteracquired infection as well as other applications, where he served as Chief Executive Officer from 2004 to 2014. He practiced clinical gastroenterology in NewYork and served as Chief of Gastroenterology at St. John’s Episcopal Hospital and South Nassau Communities Hospital from 1986 to 1995, and was aClinical Assistant Professor of Medicine at SUNY from 1983 to 1990. Dr. Jacob founded and served as Editor in Chief of Endoscopy Review and hasauthored numerous publications in the field of gastroenterology. Dr. Harvey L. Katzeff, MD, joined the Oramed Scientific Advisory Board in November 2016. Dr. Katzeff is an internationally recognized authorityon diabetes with over 30 years’ experience in academic medicine and clinical and basic research. He currently serves as Senior Director in the Cardiovascular,Metabolic, Endocrinology and Renal Division of Covance Inc. He previously was Executive Director and Global Director for Scientific Affairs for Diabetes atMerck, and former Chief of Endocrinology and Metabolism at LIJ/North Shore Health System. He was on the faculties of Cornell Medical College andRockefeller University, was President of the Eastern region of the American Diabetes Association and has received numerous honors including a NationalInstitutes of Health new investigator award. Dr. Katzeff has published over 40 original reports, book chapters and reviews. Employees We have been successful in retaining experienced personnel involved in our research and development program. In addition, we believe we havesuccessfully recruited the clinical/regulatory, quality assurance and other personnel needed to advance through clinical studies or have engaged the servicesof experts in the field for these requirements. As of August 31, 2017, we have contracted with fourteen individuals for employment or consultingarrangements. Of our staff, six are senior management, three are engaged in research and development work, and the remaining five are involved inadministration work. Additional Information Additional information about us is contained on our Internet website at www.oramed.com. Information on our website is not incorporated by referenceinto this report. On our website, under “Investors”, “SEC Filings”, we make available free of charge our Annual Reports on Form 10-K, Quarterly Reports onForm 10-Q, Current Reports on Form 8-K, and amendments to those reports filed or furnished pursuant to Section 13(a) of the Securities Exchange Act of1934, as amended, or the Exchange Act, as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC. Our reportsfiled with the SEC are also made available to read and copy at the SEC's Public Reference Room at 100 F Street, NE, Washington, D.C. 20549. You mayobtain information about the Public Reference Room by calling the SEC at 1-800-SEC-0330. Reports filed with the SEC are also made available on itswebsite at www.sec.gov. The following Corporate Governance documents are also posted on our website: Code of Ethics, Whistleblowing Policy and theCharters for each of the Audit Committee, Compensation Committee and Nominating Committee of our Board. 14  ITEM 1A. RISK FACTORS. An investment in our securities involves a high degree of risk. You should consider carefully the following information about these risks, togetherwith the other information contained in this Annual Report on Form 10-K before making an investment decision. Our business, prospects, financialcondition, and results of operations may be materially and adversely affected as a result of any of the following risks. The value of our securities coulddecline as a result of any of these risks. You could lose all or part of your investment in our securities. Some of the statements in “Item 1A. Risk Factors”are forward-looking statements. The following risk factors are not the only risk factors facing our Company. Additional risks and uncertainties notpresently known to us or that we currently deem immaterial may also affect our business, prospects, financial condition and results of operations. Risks Related to Our Business We continue, and in the future expect, to incur losses. Successful completion of our development programs and our transition to normal operations are dependent upon obtaining necessary regulatoryapprovals from the FDA prior to selling our products within the United States, and foreign regulatory approvals must be obtained to sell our productsinternationally. There can be no assurance that we will receive regulatory approval of any of our product candidates, and a substantial amount of time maypass before we achieve a level of revenues adequate to support our operations. We also expect to incur substantial expenditures in connection with theregulatory approval process for each of our product candidates during their respective developmental periods. Obtaining marketing approval will be directlydependent on our ability to implement the necessary regulatory steps required to obtain marketing approval in the United States and in other countries. Wecannot predict the outcome of these activities. Based on our current cash resources and commitments, we believe we will be able to maintain our current planned development activities and thecorresponding level of expenditures for at least the next 12 months and beyond, although no assurance can be given that we will not need additional fundsprior to such time. If there are unexpected increases in our operating expenses, we may need to seek additional financing during the next 12 months. We will need substantial additional capital in order to satisfy our business objectives. To date, we have financed our operations principally through offerings of securities and we will require substantial additional financing at variousintervals in order to continue our research and development programs, including significant requirements for operating expenses including intellectualproperty protection and enforcement, for pursuit of regulatory approvals, and for commercialization of our products. We can provide no assurance thatadditional funding will be available on a timely basis, on terms acceptable to us, or at all. In the event that we are unable to obtain such financing, we will notbe able to fully develop and commercialize our technology. Our future capital requirements will depend upon many factors, including: ●Continued scientific progress in our research and development programs, ●Costs and timing of conducting clinical trials and seeking regulatory approvals and patent prosecutions, ●Competing technological and market developments, ●Our ability to establish additional collaborative relationships, and ●Effects of commercialization activities and facility expansions if and as required. If we cannot secure adequate financing when needed, we may be required to delay, scale back or eliminate one or more of our research anddevelopment programs or to enter into license or other arrangements with third parties to commercialize products or technologies that we would otherwiseseek to develop ourselves and commercialize ourselves. In such event, our business, prospects, financial condition, and results of operations may beadversely affected as we may be required to scale-back, eliminate, or delay development efforts or product introductions or enter into royalty, sales or otheragreements with third parties in order to commercialize our products. We have a history of losses and can provide no assurance as to our future operating results. We do not have sufficient revenues from our research and development activities to fully support our operations. Consequently, we have incurrednet losses and negative cash flows since inception. We currently have only licensing revenues and no product revenues, and may not succeed in developingor commercializing any products which could generate product revenues. We do not expect to have any products on the market for several years. In addition,development of our product candidates requires a process of pre-clinical and clinical testing, during which our products could fail. We may not be able toenter into agreements with one or more companies experienced in the manufacturing and marketing of therapeutic drugs and, to the extent that we are unableto do so, we will not be able to market our product candidates. Eventual profitability will depend on our success in developing, manufacturing, andmarketing our product candidates. As of August 31, 2017, August 31, 2016 and August 31, 2015, we had working capital of $15,132,000, $27,609,000 and$15,883,000, respectively, and stockholders’ equity of $19,238,000, $26,190,000 and $24,828,000, respectively. During the 12 month periods ended August31, 2017, or fiscal 2017, and 2016, or fiscal 2016, we generated revenues of $2,456,000 and $641,000, respectively. No revenues were generated in priorperiods. For the period from our inception on April 12, 2002 through August 31, 2017, fiscal 2017, fiscal 2016, and the year ended August 31, 2015, or fiscal2015, we incurred net losses of $56,496,000, $10,480,000, $10,964,000 and $7,232,000, respectively. We may never achieve profitability and expect toincur net losses in the foreseeable future. See “Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations.” 15  We rely upon patents to protect our technology. The patent position of biopharmaceutical and biotechnology firms is generally uncertain and involves complex legal and factual questions. We donot know whether any of our current or future patent applications will result in the issuance of any patents. Even issued patents may be challenged,invalidated or circumvented. Patents may not provide a competitive advantage or afford protection against competitors with similar technology. Competitorsor potential competitors may have filed applications for, or may have received patents and may obtain additional and proprietary rights to compounds orprocesses used by or competitive with ours. In addition, laws of certain foreign countries do not protect intellectual property rights to the same extent as dothe laws of the United States. Patent litigation is becoming widespread in the biopharmaceutical and biotechnology industry and we cannot predict how this will affect our effortsto form strategic alliances, conduct clinical testing or manufacture and market any products under development. If challenged, our patents may not be heldvalid. We could also become involved in interference proceedings in connection with one or more of our patents or patent applications to determine priorityof invention. If we become involved in any litigation, interference or other administrative proceedings, we will likely incur substantial expenses and theefforts of our technical and management personnel will be significantly diverted. In addition, an adverse determination could subject us to significantliabilities or require us to seek licenses that may not be available on favorable terms, if at all. We may be restricted or prevented from manufacturing andselling our products in the event of an adverse determination in a judicial or administrative proceeding or if we fail to obtain necessary licenses. We may be unable to protect our intellectual property rights and we may be liable for infringing the intellectual property rights of others. Our ability to compete effectively will depend on our ability to maintain the proprietary nature of our technologies. We currently hold severalpending patent applications in the United States, Canada, Brazil, Europe, India, Hong Kong, Japan and China for our technologies covering oraladministration of insulin and other proteins and oral administration of exenatide and proteins, two allowed patents in Europe and Canada and 62 patentsissued by the United States, Australian, Canadian, Chinese, Israeli, Japanese, New Zealand, South African, Russian, European, Hong Kong, Swiss, German,Spanish, French, United Kingdom, Italian, Indian, Austrian, Belgian, Irish, Swedish, Danish, Luxembourg , Monaco, Norway and Dutch patent offices for ourtechnologies covering oral administration of insulin and other proteins, or for our technologies covering oral administration of exenatide, or for methods andcompositions for treating diabetes. Further, we intend to rely on a combination of trade secrets and non-disclosure and other contractual agreements andtechnical measures to protect our rights in our technology. We intend to depend upon confidentiality agreements with our officers, directors, employees,consultants, and subcontractors, as well as collaborative partners, to maintain the proprietary nature of our technology. These measures may not afford ussufficient or complete protection, and others may independently develop technology similar to ours, otherwise avoid our confidentiality agreements, orproduce patents that would materially and adversely affect our business, prospects, financial condition, and results of operations. We believe that ourtechnology is not subject to any infringement actions based upon the patents of any third parties; however, our technology may in the future be found toinfringe upon the rights of others. Others may assert infringement claims against us or against companies to which we have licensed our technology, and if weshould be found to infringe upon their patents, or otherwise impermissibly utilize their intellectual property, our ability to continue to use our technologycould be materially restricted or prohibited. If this event occurs, we may be required to obtain licenses from the holders of this intellectual property, enter intoroyalty agreements, or redesign our products so as not to utilize this intellectual property, each of which may prove to be uneconomical or otherwiseimpossible. Licenses or royalty agreements required in order for us to use this technology may not be available on terms acceptable to us, or at all. Theseclaims could result in litigation, which could materially adversely affect our business, prospects, financial condition, and results of operations. Further, wemay need to indemnify companies to which we licensed our technology in the event that such technology is found to infringe upon the rights of others. 16  Our commercial success will also depend significantly on our ability to operate without infringing the patents and other proprietary rights of thirdparties. Patent applications are, in many cases, maintained in secrecy until patents are issued. The publication of discoveries in the scientific or patentliterature frequently occurs substantially later than the date on which the underlying discoveries were made and patent applications are filed. In the event ofinfringement or violation of another party’s patent, we may be prevented from pursuing product development or commercialization. See “Item 1. Business—Description of Business—Patents and Licenses.” At present, our success depends primarily on the successful commercialization of our oral insulin capsule. The successful commercialization of oral insulin capsule is crucial for our success. At present, our principal product is the oral insulin capsule. Ouroral insulin capsule is in a clinical development stage and faces a variety of risks and uncertainties. Principally, these risks include the following: ● Future clinical trial results may show that the oral insulin capsule is not well tolerated by recipients at its effective doses or is not efficaciousas compared to placebo, ● Future clinical trial results may be inconsistent with previous preliminary testing results and data from our earlier studies may be inconsistentwith clinical data, ● Even if our oral insulin capsule is shown to be safe and effective for its intended purposes, we may face significant or unforeseen difficultiesin obtaining or manufacturing sufficient quantities or at reasonable prices, ● Our ability to complete the development and commercialization of the oral insulin capsule for our intended use is significantly dependentupon our ability to obtain and maintain experienced and committed partners to assist us with obtaining clinical and regulatory approvals for, and themanufacturing, marketing and distribution of, the oral insulin capsule on a worldwide basis, ● Even if our oral insulin capsule is successfully developed, commercially produced and receives all necessary regulatory approvals, there is noguarantee that there will be market acceptance of our product, and ● Our competitors may develop therapeutics or other treatments which are superior or less costly than our own with the result that our products,even if they are successfully developed, manufactured and approved, may not generate significant revenues. If we are unsuccessful in dealing with any of these risks, or if we are unable to successfully commercialize our oral insulin capsule for some otherreason, it would likely seriously harm our business. We have limited experience in conducting clinical trials. Clinical trials must meet FDA and foreign regulatory requirements. We have limited experience in designing, conducting and managing thepreclinical studies and clinical trials necessary to obtain regulatory approval for our product candidates in any country. We have entered into agreementswith Integrium LLC to assist us in designing, conducting and managing our various clinical trials in the United States. Any failure of Integrium LLC or anyother consultant to fulfill their obligations could result in significant additional costs as well as delays in designing, consulting and completing clinical trialson our products. 17  Our clinical trials may encounter delays, suspensions or other problems. We may encounter problems in clinical trials that may cause us or the FDA or foreign regulatory agencies to delay, suspend or terminate our clinicaltrials at any phase. These problems could include the possibility that we may not be able to conduct clinical trials at our preferred sites, enroll a sufficientnumber of patients for our clinical trials at one or more sites or begin or successfully complete clinical trials in a timely fashion, if at all. Furthermore, we, theFDA or foreign regulatory agencies may suspend clinical trials at any time if we or they believe the subjects participating in the trials are being exposed tounacceptable health risks or if we or they find deficiencies in the clinical trial process or conduct of the investigation. If clinical trials of any of the productcandidates fail, we will not be able to market the product candidate which is the subject of the failed clinical trials. The FDA and foreign regulatory agenciescould also require additional clinical trials, which would result in increased costs and significant development delays. Our failure to adequately demonstratethe safety and effectiveness of a pharmaceutical product candidate under development could delay or prevent regulatory approval of the product candidateand could have a material adverse effect on our business, prospects, financial condition, and results of operations. We can provide no assurance that our products will obtain regulatory approval or that the results of clinical studies will be favorable. The testing, marketing and manufacturing of any of our products will require the approval of the FDA or regulatory agencies of other countries. Wehave completed certain non-FDA clinical trials and pre-clinical trials for our products. In addition, we have completed a Phase IIb clinical trial in patientswith type 2 diabetes under an IND with the FDA and we have completed Phase IIa clinical trials of ORMD-0801 in patients with type 1 diabetes under an INDwith the FDA. However, success in pre-clinical testing and early clinical trials does not ensure that later clinical trials will be successful. For example, anumber of companies in the pharmaceutical industry have suffered significant setbacks in advanced clinical trials. We cannot predict with any certainty the amount of time necessary to obtain regulatory approvals, including from the FDA or other foreignregulatory authorities, and whether any such approvals will ultimately be granted. In any event, review and approval by the regulatory bodies is anticipatedto take a number of years. Preclinical and clinical trials may reveal that one or more of our products are ineffective or unsafe, in which event furtherdevelopment of such products could be seriously delayed or terminated. Moreover, obtaining approval for certain products may require the testing on humansubjects of substances whose effects on humans are not fully understood or documented. Delays in obtaining necessary regulatory approvals of any proposedproduct and failure to receive such approvals would have an adverse effect on the product’s potential commercial success and on our business, prospects,financial condition, and results of operations. In addition, it is possible that a product may be found to be ineffective or unsafe due to conditions or factswhich arise after development has been completed and regulatory approvals have been obtained. In this event we may be required to withdraw such productfrom the market. See “Item 1. Business—Description of Business—Government Regulation.” We are dependent upon third party suppliers of our raw materials. We are dependent on outside vendors for our entire supply of the oral insulin and GLP-1 capsules and do not currently have any long-termagreements in place for the supply of oral insulin or GLP-1 capsules. While we believe that there are numerous sources of supply available, if the third partysuppliers were to cease production or otherwise fail to supply us with quality raw materials in sufficient quantities on a timely basis and we were unable tocontract on acceptable terms for these services with alternative suppliers, our ability to produce our products and to conduct testing and clinical trials wouldbe materially adversely affected. Our future revenues from HTIT are dependent upon third party suppliers and Chinese regulatory approvals. Our future revenues from HTIT are dependent upon the achievement of certain milestones and conditions, and the success of HTIT to implement ourtechnology and to manufacture the oral insulin capsule. Our future revenues from HTIT are also dependent upon the ability of third parties to scale-up one ofour oral capsule ingredients and to scale-up the manufacturing process of our capsules. Our future revenues from royalties from HTIT are further dependentupon the granting of regulatory approvals in the Territory. Accordingly, if any of the foregoing does not occur, we may not be successful in receiving futurerevenues from HTIT and may not succeed with our business plans in China. 18  We are highly dependent upon our ability to enter into agreements with collaborative partners to develop, commercialize, and market ourproducts. Our long-term strategy is to ultimately seek a strategic commercial partner, or partners, such as large pharmaceutical companies, with extensiveexperience in the development, commercialization, and marketing of insulin applications and/or other orally digestible drugs. We anticipate such partner orpartners would be responsible for, or substantially support, late stage clinical trials (Phase III) and sales and marketing of our oral insulin capsule and otherproducts. Such planned strategic partnership, or partnerships, may provide a marketing and sales infrastructure for our products as well as financial andoperational support for global clinical trials, post marketing studies, label expansions and other regulatory requirements concerning future clinicaldevelopment in the United States and elsewhere. While our strategy is to partner with an appropriate party, no assurance can be given that any third party would be interested in partnering with us.We currently lack the resources to manufacture any of our product candidates on a large scale and we have no sales, marketing or distribution capabilities. Inthe event we are not able to enter into a collaborative agreement with a partner or partners, on commercially reasonable terms, or at all, we may be unable tocommercialize our products, which would have a material adverse effect upon our business, prospects, financial condition, and results of operations. The biotechnology and biopharmaceutical industries are characterized by rapid technological developments and a high degree of competition.We may be unable to compete with more substantial enterprises. The biotechnology and biopharmaceutical industries are characterized by rapid technological developments and a high degree of competition. As aresult, our products could become obsolete before we recoup any portion of our related research and development and commercialization expenses. Theseindustries are highly competitive, and this competition comes both from biotechnology firms and from major pharmaceutical and chemical companies. Manyof these companies have substantially greater financial, marketing, and human resources than we do (including, in some cases, substantially greaterexperience in clinical testing, manufacturing, and marketing of pharmaceutical products). We also experience competition in the development of ourproducts from universities and other research institutions and compete with others in acquiring technology from such universities and institutions. Inaddition, certain of our products may be subject to competition from products developed using other technologies. See “Item 1. Business—Description ofBusiness—Competition.” We have limited senior management resources and may be required to obtain more resources to manage our growth. We expect the expansion of our business to place a significant strain on our limited managerial, operational, and financial resources. We will berequired to expand our operational and financial systems significantly and to expand, train, and manage our work force in order to manage the expansion ofour operations. Our failure to fully integrate our new employees into our operations could have a material adverse effect on our business, prospects, financialcondition, and results of operations. Our ability to attract and retain highly skilled personnel is critical to our operations and expansion. We face competitionfor these types of personnel from other technology companies and more established organizations, many of which have significantly larger operations andgreater financial, technical, human, and other resources than we have. We may not be successful in attracting and retaining qualified personnel on a timelybasis, on competitive terms, or at all. If we are not successful in attracting and retaining these personnel, our business, prospects, financial condition, andresults of operations will be materially adversely affected. See “Item 7. Management’s Discussion and Analysis of Financial Condition and Results ofOperations,” “Item 1. Business—Description of Business—Strategy” and “—Employees.” We depend upon our senior management and skilled personnel and their loss or unavailability could put us at a competitive disadvantage. We currently depend upon the efforts and abilities of our senior executives, as well as the services of several key consultants and other keypersonnel, including Dr. Miriam Kidron, our Chief Scientific Officer. The loss or unavailability of the services of any of these individuals for any significantperiod of time could have a material adverse effect on our business, prospects, financial condition, and results of operations. We do not maintain “key man”life insurance policies for any of our senior executives. In addition, recruiting and retaining qualified scientific personnel to perform future research anddevelopment work will be critical to our success. There is currently a shortage of employees with expertise in developing, manufacturing andcommercialization of products and related clinical and regulatory affairs, and this shortage is likely to continue. Competition for skilled personnel is intenseand turnover rates are high. Our ability to attract and retain qualified personnel may be limited. Our inability to attract and retain qualified skilled personnelwould have a material adverse effect on our business, prospects, financial condition, and results of operations. 19  Healthcare policy changes, including pending legislation recently adopted and further proposals still pending to reform the U.S. healthcaresystem, may harm our future business. Healthcare costs have risen significantly over the past decade. There have been and continue to be proposals by legislators, regulators and third-party payors to keep these costs down. Certain proposals, if passed, would impose limitations on the prices we will be able to charge for the products that weare developing, or the amounts of reimbursement available for these products from governmental agencies or third-party payors. These limitations could inturn reduce the amount of revenues that we will be able to generate in the future from sales of our products and licenses of our technology. In 2010, the federal government enacted healthcare reform legislation that has significantly impacted the pharmaceutical industry. In addition torequiring most individuals to have health insurance and establishing new regulations on health plans, this legislation requires discounts under the Medicaredrug benefit program and increased rebates on drugs covered by Medicaid. In addition, the legislation imposes an annual fee, which has increased annually,on sales by branded pharmaceutical manufacturers. There can be no assurance that our business will not be materially adversely affected by these increasedrebates, fees and other provisions. In addition, these and other initiatives in the United States may continue the pressure on drug pricing, especially under theMedicare and Medicaid programs, and may also increase regulatory burdens and operating costs. The announcement or adoption of any such initiative couldhave an adverse effect on potential revenues from any product that we may successfully develop. An expansion in government’s role in the U.S. healthcareindustry may lower the future revenues for the products we are developing and adversely affect our future business, possibly materially. In September 2017, members of the U.S. Congress introduced legislation with the announced intention to repeal and replace major provisions of thePatient Protection and Affordable Care Act, or the ACA. Although it is unclear whether such legislation will ultimately become law, attempts to repeal or torepeal and replace the ACA will likely continue. In addition, various other healthcare reform proposals have also emerged at the federal and state level. Wecannot predict what healthcare initiatives, if any, will be implemented at the federal or state level, or the effect any future legislation or regulation will haveon us. We are exposed to fluctuations in currency exchange rates. A considerable amount of our expenses are generated in dollars or in dollar-linked currencies, but a significant portion of our expenses such as someclinical studies and payroll costs are generated in other currencies such as NIS, Euro and British pounds. Most of the time, our non-dollar assets are not totallyoffset by non-dollar liabilities. Due to the foregoing and to the fact that our financial results are measured in dollars, our results could be adversely affected asa result of a strengthening or weakening of the dollar compared to these other currencies. During the fiscal years ended August 31, 2013, 2014 and 2017, thedollar depreciated in relation to the NIS, which raised the dollar cost of our Israeli based operations and adversely affected our financial results, while duringfiscals 2015 and 2016, the dollar increased in relation to the NIS, which reduced the dollar cost of our Israeli based operations costs. In addition, our resultscould also be adversely affected if we are unable to guard against currency fluctuations in the future. Although we may in the future decide to undertakeforeign exchange hedging transactions to cover a portion of our foreign currency exchange exposure, we currently do not hedge our exposure to foreigncurrency exchange risks. These transactions, however, may not adequately protect us from future currency fluctuations and, even if they do protect us, mayinvolve operational or financing costs we would not otherwise incur. 20  Risks Related to our Common Stock As the market price of our common stock may fluctuate significantly, this may make it difficult for you to sell your shares of common stockwhen you want or at prices you find attractive. The price of our common stock is currently listed on The Nasdaq Capital Market, or Nasdaq, and on the Tel Aviv Stock Exchange and constantlychanges. In recent years, the stock market in general has experienced extreme price and volume fluctuations. We expect that the market price of our commonstock will continue to fluctuate. These fluctuations may result from a variety of factors, many of which are beyond our control. These factors include: ●Clinical trial results and the timing of the release of such results, ●The amount of cash resources and our ability to obtain additional funding, ●Announcements of research activities, business developments, technological innovations or new products by us or our competitors, ●Entering into or terminating strategic relationships, ●Changes in government regulation, ●Departure of key personnel, ●Disputes concerning patents or proprietary rights, ●Changes in expense level, ●Future sales of our equity or equity-related securities, ●Public concern regarding the safety, efficacy or other aspects of the products or methodologies being developed, ●Activities of various interest groups or organizations, ●Media coverage, and ●Status of the investment markets. Future sales of common stock or the issuance of securities senior to our common stock or convertible into, or exchangeable or exercisable for,our common stock could materially adversely affect the trading price of our common stock, and our ability to raise funds in new equity offerings. Future sales of substantial amounts of our common stock or other equity-related securities in the public market or privately, or the perception thatsuch sales could occur, could adversely affect prevailing trading prices of our common stock and could impair our ability to raise capital through futureofferings of equity or other equity-related securities. We anticipate that we will need to raise capital through offerings of equity and equity related securities.We can make no prediction as to the effect, if any, that future sales of shares of our common stock or equity-related securities, or the availability of shares ofcommon stock for future sale, will have on the trading price of our common stock. Our stockholders may experience significant dilution as a result of any additional financing using our equity securities. To the extent that we raise additional funds by issuing equity securities, our stockholders may experience significant dilution. Our management will have significant flexibility in using the net proceeds of any offering of securities. We intend generally to use the net proceeds from any offerings of our securities for expenses related to our clinical trials, research and productdevelopment activities, and for general corporate purposes, including general working capital purposes. Our management will have significant flexibility inapplying the net proceeds of any such offering. The actual amounts and timing of expenditures will vary significantly depending on a number of factors,including the amount of cash used in our operations and our research and development efforts. Management’s failure to use these funds effectively wouldhave an adverse effect on the value of our common stock and could make it more difficult and costly to raise funds in the future. 21  Future sales of our common stock by our existing stockholders could adversely affect our stock price. The market price of our common stock could decline as a result of sales of a large number of shares of our common stock in the market, or theperception that these sales could occur. These sales also might make it more difficult for us to sell equity securities in the future at a time and at a price thatwe deem appropriate. As of November 28, 2017, we had outstanding 14,306,100 shares of common stock, a large majority of which are freely tradable. Givingeffect to the exercise in full of all of our outstanding warrants, options and restricted stock units, or RSUs, including those currently unexercisable orunvested, we would have outstanding 15,722,651 shares of common stock. Our issuance of warrants, options and RSUs to investors, employees and consultants may have a negative effect on the trading prices of ourcommon stock as well as a dilutive effect. We have issued and may continue to issue warrants, options, RSUs and convertible notes at, above or below the current market price. As ofNovember 28, 2017, we had outstanding warrants and options exercisable for 1,221,855 shares of common stock at a weighted average exercise price of$7.11. We also had outstanding RSUs exercisable for 164,636 shares of common stock at a total exercise price of $900. In addition to the dilutive effect of alarge number of shares of common stock and a low exercise price for the warrants and options, there is a potential that a large number of underlying shares ofcommon stock may be sold in the open market at any given time, which could place downward pressure on the trading of our common stock. Delaware law could discourage a change in control, or an acquisition of us by a third party, even if the acquisition would be favorable to you,and thereby adversely affect existing stockholders. The Delaware General Corporation Law contains provisions that may have the effect of making more difficult or delaying attempts by others toobtain control of our Company, even when these attempts may be in the best interests of stockholders. Delaware law imposes conditions on certain businesscombination transactions with “interested stockholders.” These provisions and others that could be adopted in the future could deter unsolicited takeovers ordelay or prevent changes in our control or management, including transactions in which stockholders might otherwise receive a premium for their shares ofcommon stock over then current market prices. These provisions may also limit the ability of stockholders to approve transactions that they may deem to bein their best interests. Because we will not pay cash dividends, investors may have to sell shares of our common stock in order to realize their investment. We have not paid any cash dividends on our common stock and do not intend to pay cash dividends in the foreseeable future. We intend to retainfuture earnings, if any, for reinvestment in the development and expansion of our business. Any credit agreements which we may enter into with institutionallenders or otherwise may restrict our ability to pay dividends. Whether we pay cash dividends in the future will be at the discretion of our Board and will bedependent upon our financial condition, results of operations, capital requirements, and any other factors that our Board decides is relevant. See “Item 5.Market Price for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities.” Because certain of our stockholders control a significant number of shares of our common stock, they may have effective control over actionsrequiring stockholder approval. As of November 28, 2017, our directors, executive officers and principal affiliated stockholders beneficially own approximately 33.6% of ouroutstanding shares of common stock, excluding shares issuable upon the exercise of options, warrants and RSUs. As a result, these stockholders, should theyact together, may have the ability to control the outcome of matters submitted to our stockholders for approval, including the election of directors and anymerger, consolidation or sale of all or substantially all of our assets. In addition, these stockholders, should they act together, may have the ability to controlour management and affairs. Accordingly, this concentration of ownership might harm the market price of our common stock by: ●Delaying, deferring or preventing a change in corporate control, ●Impeding a merger, consolidation, takeover or other business combination involving us, or ●Discouraging a potential acquirer from making a tender offer or otherwise attempting to obtain control of us. 22  Risks Related to Conducting Business in Israel We are affected by the political, economic, and military risks of locating our principal operations in Israel. Our operations are located in the State of Israel, and we are directly affected by political, economic, and security conditions in that country. Sincethe establishment of the State of Israel in 1948, a number of armed conflicts have taken place between Israel and its Arab neighbors and a state of hostility,varying in degree and intensity, has led to security and economic problems for Israel. In addition, acts of terrorism, armed conflicts or political instability inthe region could negatively affect local business conditions and harm our results of operations. We cannot predict the effect on the region of any diplomaticinitiatives or political developments involving Israel or the Palestinians or other countries and territories in the Middle East. Recent political events,including political uprisings, social unrest and regime change, in various countries in the Middle East and North Africa have weakened the stability of thosecountries and territories, which could result in extremists coming to power. In addition, Iran has threatened to attack Israel and is widely believed to bedeveloping nuclear weapons. Iran is also believed to have a strong influence among extremist groups in the region, such as Hamas in Gaza and Hezbollah inLebanon. This situation has escalated in the past and may potentially escalate in the future to violent events which may affect Israel and us. Our business,prospects, financial condition, and results of operations could be materially adversely affected if major hostilities involving Israel should occur or if tradebetween Israel and its current trading partners is interrupted or curtailed. All adult male permanent residents of Israel, unless exempt, may be required to perform military reserve duty annually. Additionally, all suchresidents are subject to being called to active duty at any time under emergency circumstances. Some of our officers, directors, and employees currently areobligated to perform annual military reserve duty. We can provide no assurance that such requirements will not have a material adverse effect on ourbusiness, prospects, financial condition, and results of operations in the future, particularly if emergency circumstances occur. Because we received grants from the Israel Innovation Authority we are subject to ongoing restrictions. We received royalty-bearing grants from the Israel Innovation Authority, or IIA, of the Israeli Ministry of Economy & Industry, Trade and Labor, forresearch and development programs that meet specified criteria. We did not recognize any grants in fiscals 2017 and 2016, and recognized a grant in theamount of $49,000 in fiscal 2015. We do not expect to receive further grants from the IIA in the future. The terms of the IIA grants limit our ability to transferknow-how developed under an approved research and development program outside of Israel, regardless of whether the royalties were fully paid. It may be difficult to enforce a U.S. judgment against us or our officers and directors and to assert U.S. securities laws claims in Israel. Almost all of our directors and officers are nationals and/or residents of countries other than the United States. As a result, service of process upon us,our Israeli subsidiary and our directors and officers, may be difficult to obtain within the United States. Furthermore, because the majority of our assets andinvestments, and most of our directors and officers are located outside the United States, it may be difficult for investors to enforce within the United Statesany judgments obtained against us or any such officers or directors. Additionally, it may be difficult to assert U.S. securities law claims in original actionsinstituted in Israel. Israeli courts may refuse to hear a claim based on a violation of U.S. securities laws because Israel is not the most appropriate forum inwhich to bring such a claim. In addition, even if an Israeli court agrees to hear a claim, it may determine that Israeli law and not U.S. law is applicable to suchclaim. If U.S. law is found to be applicable, the content of applicable U.S. law must be proved as a fact, which can be a time-consuming and costly process.Certain matters of procedure will also be governed by Israeli law. 23  Subject to specified time limitations and legal procedures, under the rules of private international law currently prevailing in Israel, Israeli courtsmay enforce a U.S. judgment in a civil matter, including a judgment based upon the civil liability provisions of the U.S. securities laws, as well as a monetaryor compensatory judgment in a non-civil matter, provided that the following key conditions are met: ●subject to limited exceptions, the judgment is final and non-appealable; ●the judgment was given by a court competent under the laws of the state in which the court is located and is otherwise enforceable in such state; ●the judgment was rendered by a court competent under the rules of private international law applicable in Israel; ●the laws of the state in which the judgment was given provides for the enforcement of judgments of Israeli courts; ●adequate service of process has been effected and the defendant has had a reasonable opportunity to present his arguments and evidence; ●the judgment and its enforcement are not contrary to the law, public policy, security or sovereignty of the State of Israel; ●the judgment was not obtained by fraud and does not conflict with any other valid judgment in the same matter between the same parties; and ●an action between the same parties in the same matter was not pending in any Israeli court at the time the lawsuit was instituted in the U.S. court. If any of these conditions are not met, Israeli courts will likely not enforce the applicable U.S. judgment. ITEM 1B. UNRESOLVED STAFF COMMENTS. Not applicable. ITEM 2. PROPERTIES. Our principal executive offices are comprised of approximately 168 square meters of leased office space in Givat-Ram, Jerusalem, Israel. The currentlease term is from October 1, 2016 until September 30, 2021. The aggregate annual base rent for this space is currently $33,000, linked to the increase in theIsraeli consumer price index, and will be increased to $37,000 in October 2018. We believe that our existing facilities are suitable and adequate to meet ourcurrent business requirements. In the event that we should require additional or alternative facilities, we believe that such facilities can be obtained on shortnotice at competitive rates. As security for our obligations under the lease agreement, we provided a bank guarantee in an amount equal to three monthly lease payments, validuntil December 31, 2021. ITEM 3. LEGAL PROCEEDINGS. From time to time we may become subject to litigation incidental to our business. We are not currently a party to any material legal proceedings. ITEM 4. MINE SAFETY DISCLOSURES. Not applicable. 24  PART II ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITYSECURITIES. Market Price for our Common Stock Our common stock is traded on Nasdaq and on the Tel Aviv Stock Exchange, in each case under the symbol “ORMP.” The quarterly high and lowsales price on Nasdaq for the periods indicated are as follows: High Low Year Ended August 31, 2016 Three Months Ended November 30, 2015 $10.74 $5.40 Three Months Ended February 29, 2016 $9.95 $5.60 Three Months Ended May 31, 2016 $10.51 $6.06 Three Months Ended August 31, 2016 $8.82 $7.10 Year Ended August 31, 2017 Three Months Ended November 30, 2016 $8.01 $5.70 Three Months Ended February 28, 2017 $6.97 $5.82 Three Months Ended May 31, 2017 $8.94 $5.85 Three Months Ended August 31, 2017 $9.17 $7.08 The last reported sale price per share of common stock as quoted on Nasdaq was $9.46 on November 28, 2017. Holders As of November 28, 2017, there were 14,306,100 shares of our common stock issued and outstanding held of record by approximately 50 registeredstockholders. We believe that a significant number of stockholders hold their shares of our common stock in brokerage accounts and registered in the name ofstock depositories and are therefore not included in the number of stockholders of record. Dividend Policy We have never paid any cash dividends on our capital stock and do not anticipate paying any cash dividends on our common stock in theforeseeable future. We intend to retain future earnings to fund ongoing operations and future capital requirements of our business. Any future determinationto pay cash dividends will be at the discretion of our Board and will be dependent upon our financial condition, results of operations, capital requirementsand such other factors as our Board deems relevant. Unregistered Sales of Equity Securities and Use of Proceeds On August 1, 2017, we issued 2,500 shares of our common stock, valued at $20,000, in the aggregate, to Corporate Profile, LLC, or CorporateProfile, in payment of a portion of the consulting fee for investor relations services owed to Corporate Profile pursuant to a Letter Agreements, dated May 3,2017, between us and Corporate Profile. On August 8, 2017, we issued 5,631 shares of our common stock to an investor resulting from his exercise of warrants purchased in connection withour 2012 private placement for a total exercise price of $33,786. These issuances and sales were exempt under Section 4(a)(2) of the Securities Act of 1933, as amended. 25  Comparative Stock Performance Graph The following graph shows how an initial investment of $100 in our common stock would have compared to an equal investment in the NasdaqComposite Index and the Nasdaq Biotechnology Index during the period from September 1, 2012 through August 31, 2017. The performance shown is notnecessarily indicative of future price performance. ITEM 6. SELECTED FINANCIAL DATA. The selected data presented below under the captions “Statements of Comprehensive Loss Data” and “Balance Sheet Data” for, and as of the end of,each of the fiscal years in the five-year period ended August 31, 2017, are derived from, and should be read in conjunction with, our audited consolidatedfinancial statements. The selected information contained in this table should also be read in conjunction with “Management's Discussion and Analysis of FinancialCondition and Results of Operations” and the consolidated financial statements and related notes thereto included elsewhere in this Annual Report on Form10-K. The selected consolidated statements of comprehensive loss data for fiscals 2017, 2016 and 2015 and the selected consolidated balance sheet data as ofAugust 31, 2017 and 2016, are derived from the audited consolidated financial statements included elsewhere in this Annual Report. The statement ofoperations data for the years ended August 31, 2014 and 2013 and the balance sheet data as of August 31, 2015, 2014 and 2013 are derived from auditedfinancial statements not included in this Annual Report. The historical results presented below are not necessarily indicative of future results. 2017 2016 2015 2014 2013 (in thousands of dollars except share and per share data) Statements of Comprehensive Loss: Revenues $2,456 $641 $- $- $- Cost of revenues 187 490 - - - Research and development expenses, net 10,281 7,709 4,781 3,277 2,272 General and administrative expenses 2,759 2,452 2,602 2,629 2,032 Financial income 792 474 168 225 180 Financial expenses 101 93 18 11 313 Loss before taxes on income 10,080 9,629 7,233 5,692 4,437 Taxes on income (Tax benefit) 400 1,335 (1) 4 (205)Net loss for the year $10,480 $10,964 $7,232 $5,696 $4,232 Loss per common share – basic and diluted $0.79 $0.87 $0.67 $0.62 $0.59 Weighted average common shares outstanding 13,296,633 12,624,356 10,820,465 9,244,059 7,209,283 As of August 31, 2017 2016 2015 2014 2013 in thousands of dollars except share and per share data Balance Sheet Data: Cash, cash equivalents, short-term deposits, restricted cash andmarketable securities $20,138 $31,032 $17,245 $21,306 $8,491 Other current assets 159 198 127 472 153 Long-term deposits and other assets 16,264 11,070 8,042 24 16 Long-term marketable securities 2,151 530 940 - - Total assets 38,712 42,830 26,354 21,802 8,660 Current liabilities 5,165 3,621 1,489 973 498 Long-term liabilities 14,309 13,019 37 36 31 Stockholders’ equity 19,238 26,190 24,828 20,793 8,131 26  ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS. The following discussion and analysis of our financial condition and results of operations should be read in conjunction with the consolidatedfinancial statements and the related notes included elsewhere herein and in our consolidated financial statements. In addition to our consolidated financial statements, the following discussion contains forward-looking statements that reflect our plans, estimatesand beliefs. Our actual results could differ materially from those discussed in the forward-looking statements. Factors that could cause or contribute to thesedifferences include those discussed below and elsewhere in this Annual Report on Form 10-K, particularly in “Cautionary Statement Regarding Forward-Looking Statements” and “Item 1A. Risk Factors.” Overview of Operations We are a pharmaceutical company currently engaged in the research and development of innovative pharmaceutical solutions, including an orallyingestible insulin capsule to be used for the treatment of individuals with diabetes, and the use of orally ingestible capsules or pills for delivery of otherpolypeptides. Oral Insulin: We are seeking to revolutionize the treatment of diabetes through our proprietary flagship product, ORMD-0801, an orally ingestibleinsulin capsule. We completed a Phase IIb clinical trial in patients with type 2 diabetes under an IND with the FDA, following which we conducted a PhaseIIa, dose finding clinical trial to better define the optimal dosing of ORMD-0801 moving forward. We also completed Phase IIa clinical trials in patients withboth type 1 and type 2 diabetes. During a call with the FDA regarding ORMD-0801, we were advised that the regulatory pathway for submission of ORMD-0801 would be a BLA, and we plan to initiate a three-month trial in patients with type 2 diabetes to evaluate the effect of ORMD-0801 on HbA1c, the mainFDA registrational endpoint. GLP-1 Analog: Our second pipeline product, ORMD-0901, is an orally ingestible exenatide (GLP-1 analog) capsule, which aids in the balance ofblood-sugar levels and decreases appetite. In January 2013, we began a clinical trial for our oral exenatide capsule on healthy volunteers and type 2 diabeticpatients. Based on this study, we decided to make slight adjustments in the manufacturing of these capsules and have begun pre-clinical studies on the newcapsules. In September 2013, we submitted a pre-IND package to the FDA for ORMD-0901, our oral exenatide capsule. We completed during the secondquarter of calendar year 2016 a Phase Ib trial outside of the United States, which began in August 2015. We also completed a pre-clinical toxicology study inMarch 2017, anticipate receiving the final report during the fourth quarter of calendar year 2017 and expect to file an IND and move directly into apharmacokinetics study followed by a large Phase II trial in the United States under an FDA IND. Combination of Oral Insulin and GLP-1 Analog: Our third pipeline product is a combination of our two primary products, oral insulin and oralexenatide. In the near term, we are focusing our efforts on the development of the Company’s flagship products, oral insulin and oral exenatide. Once thesetwo products have progressed further in clinical trials, we intend on running further studies with the oral combination therapy. Results of Operations Critical accounting policies Our significant accounting policies are more fully described in the notes to our accompanying consolidated financial statements. We believe thatthe accounting policies below are critical for one to fully understand and evaluate our financial condition and results of operations. The discussion and analysis of our financial condition and results of operations is based on our consolidated financial statements, which weprepared in accordance with U.S. generally accepted accounting principles, or GAAP. The preparation of our consolidated financial statements requires us tomake estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date ofthe consolidated financial statements, as well as the reported revenues and expenses during the reporting periods. On an ongoing basis, we evaluate suchestimates and judgments. We base our estimates on historical experience and on various other factors that we believe are reasonable under the circumstances,the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources.Actual results may differ from these estimates under different assumptions or conditions. 27  Valuation of options and warrants: We grant options to purchase shares of our common stock to employees and consultants and issue warrants inconnection with some of our financings and to certain other consultants. We account for share-based payments to employees and directors in accordance with the guidance that requires awards classified as equity awards tobe accounted for using the grant-date fair value method. The fair value of share-based payment transactions is based on the Black Scholes option-pricingmodel or Monte Carlo model when appropriate, and is recognized as an expense over the requisite service period. We elected to recognize compensation cost for awards to employees and directors that have a graded vesting schedule using the accelerated methodbased on the multiple-option award approach. When stock options are granted as consideration for services provided by consultants and other non-employees, the transaction is accounted forbased on the fair value of the consideration received or the fair value of the stock options issued, whichever is more reliably measurable. The fair value of theoptions granted is measured on each reporting date, and the gains (losses) are recorded to earnings over the related service period using the straight-linemethod. Revenue recognition: Revenue is recognized when delivery has occurred, evidence of an arrangement exists, title and risks and rewards for theproducts are transferred to the customer and collection is reasonably assured. Given our continuing involvement through the expected product submission (June 2023), revenue from the License Agreement is recognized overthe periods from which the Company is entitled to the respective payments (including milestones), and through the expected product submission date. Comparison of Fiscal 2017 to Fiscal 2016 and Fiscal 2016 to Fiscal 2015 The following table summarizes certain statements of operations data for us for the twelve month periods ended August 31, 2017, 2016 and 2015: Year ended August 31, Operating Data: 2017 2016 2015 (dollar amounts in thousands) Revenues $2,456 $641 $- Cost of revenues 187 490 - Research and development expenses, net 10,281 7,709 4,781 General and administrative expenses 2,759 2,452 2,602 Financial income, net 691 381 150 Loss before taxes on income 10,080 9,629 7,233 Taxes on income (Tax benefit) 400 1,335 (1)Net loss for the year 10,480 10,964 7,232 Loss per common share – basic and diluted $0.79 $0.87 $0.67 Weighted average common shares outstanding 13,296,633 12,624,356 10,820,465 Revenues Revenues consist of proceeds related to the License Agreement that are recognized over the term of the License Agreement through June 2023. Revenues for fiscal 2017 increased by 283% to $2,456,000 from $641,000 for fiscal 2016. The increase is attributed to additional milestonepayments received in connection with the License Agreement. No revenues were recorded for fiscal 2015. Cost of revenues Cost of revenues consists of royalties related to the License Agreement with HTIT that will be paid over the term of the License Agreement inaccordance with the revenue recognition and the Law for the Encouragement of Industrial Research, Development and Technological Innovation, 1984, asamended, including any regulations or tracks promulgated thereunder, or the R&D Law. Cost of revenues for fiscal 2017 decreased by 62% to $187,000 from $490,000 for fiscal 2016. The decrease reflects a decrease in the total proceedsrelated to the License Agreement received during the year. No cost of revenues was recorded for fiscal 2015. 28  Research and development expenses Research and development expenses include costs directly attributable to the conduct of research and development programs, including the cost ofsalaries, employee benefits, costs of materials, supplies, the cost of services provided by outside contractors, including services related to our clinical trials,clinical trial expenses, the full cost of manufacturing drug for use in research and preclinical development. All costs associated with research anddevelopment are expensed as incurred. Clinical trial costs are a significant component of research and development expenses and include costs associated with third-party contractors. Weoutsource a substantial portion of our clinical trial activities, utilizing external entities such as CROs, independent clinical investigators, and other third-party service providers to assist us with the execution of our clinical studies. Clinical activities which relate principally to clinical sites and other administrative functions to manage our clinical trials are performed primarilyby CROs. CROs typically perform most of the start-up activities for our trials, including document preparation, site identification, screening and preparation,pre-study visits, training, and program management. Clinical trial and pre-clinical trial expenses include regulatory and scientific consultants’ compensation and fees, research expenses, purchase ofmaterials, cost of manufacturing of the oral insulin and exenatide capsules, payments for patient recruitment and treatment, as well as salaries and relatedexpenses of research and development staff. From August 2009 to March 2014, Oramed Ltd. was awarded five government grants amounting to a total net amount of NIS 8 million(approximately $2,194,000) from the IIA. We used the funds to support further research and development and clinical studies of our oral insulin capsule andoral GLP-1 analog during the period from February 2009 to December 2014. The five grants are subject to repayment according to the terms determined bythe IIA and applicable law. See “—Government grants” below. Research and development expenses, net, for fiscal 2017 increased by 33% to $10,281,000 from $7,709,000 for fiscal 2016. The increase is mainlyattributed to expenses related to process development and production of our capsules and the required ingredients, progress in toxicology studies andincrease in stock-based compensation costs, partially offset by a decrease in clinical trials due to completion of our Phase IIb clinical trial. During fiscal 2017,stock-based compensation costs totaled $1,134,000, as compared to $304,000 during fiscal 2016. Research and development expenses, net, for fiscal 2016 increased by 61% to $7,709,000 from $4,781,000 for fiscal 2015. The increase is attributedto expenses related to clinical trials and mainly our Phase IIb clinical trial. This increase was partially offset by a decrease in stock based compensation costs.During fiscal 2016, stock based compensation costs totaled $304,000, as compared to $616,000 during fiscal 2015. Government grants The Government of Israel encourages research and development projects through the IIA, pursuant to the R&D Law. Under the R&D Law, a researchand development plan that meets specified criteria is eligible for a grant of up to 50% of certain approved research and development expenditures. Each planmust be approved by the IIA. In fiscals 2017 and 2016, we did not recognize any research and development grants and in fiscal 2015, we recognized a research and developmentgrant in an amount of $49,000. As of August 31, 2017, we incurred a liability to pay royalties to the IIA of $533,000. Under the terms of the grants we received from the IIA, we are obligated to pay royalties of 3.5% on all revenues derived from the sale of the productsdeveloped pursuant to the funded plans, including revenues from licensed ancillary services. Royalties are generally payable up to a maximum amountequaling 100% of the grants received (dollar linked) with the addition of interest at an annual rate based on the LIBOR rate. The R&D Law generally requires that a product developed under a program be manufactured in Israel. However, when applying for a grant, theapplicant may declare that part of the manufacturing will be performed outside of Israel or by non-Israeli residents and if the IIA is convinced that performingsome of the manufacturing abroad is essential for the execution of the program, it may still approve the grant. This declaration will be a significant factor inthe determination of the IIA as to whether to approve a program and the amount and other terms of the benefits to be granted. If a company wants to increasethe volume of manufacturing outside of Israel after the grant has been approved, it may transfer up to 10% of the company’s approved Israeli manufacturingvolume, measured on an aggregate basis, outside of Israel after first notifying the IIA thereof (provided that the IIA does not object to such transfer within 30days). In addition, upon the approval of the IIA, a portion greater than 10% of the manufacturing volume may be performed outside of Israel. In any case oftransfer of manufacturing out of Israel, the grant recipient is required to pay royalties at an increased rate, which may be substantial, and the aggregaterepayment amount is increased up to 120%, 150% or 300% of the grant, depending on the portion of the total manufacturing volume that is performedoutside of Israel. The approval we received from the IIA for the License Agreement was subject to payment of increased royalties and an increased ceiling, allin accordance with the provisions of the R&D Law. The R&D Law further permits the IIA, among other things, to approve the transfer of manufacturing rightsoutside of Israel in exchange for the import of different manufacturing into Israel as a substitute, in lieu of the increased royalties. 29  The R&D Law also provides that know-how developed under an approved research and development program may not be transferred or licensed tothird parties in Israel without the approval of the research committee. Such approval is not required for the sale or export of any products resulting from suchresearch or development. The R&D Law further provides that the know-how developed under an approved research and development program may not betransferred or licensed to any third parties outside Israel absent IIA approval which may be granted in certain circumstances as follows: (a) the grant recipientpays to the IIA a portion of the sale or license price paid in consideration for the purchase or license of such IIA-funded know-how or the price paid inconsideration for the sale of the grant recipient itself, as the case may be, in accordance with certain formulas included in the R&D Law; (b) the grantrecipient receives know-how from a third party in exchange for its IIA-funded know-how; or (c) such transfer of IIA-funded know-how is made in the contextof IIA approved research and development cooperation projects or consortia. The R&D Law imposes reporting requirements with respect to certain changes in the ownership of a grant recipient. The R&D Law requires the grantrecipient to notify the IIA of any change in control of the recipient or a change in the holdings of the means of control of the recipient that results in a non-Israeli entity becoming an interested party in the recipient, and requires the new non-Israeli interested party to undertake to the IIA to comply with the R&DLaw. In addition, the rules of the IIA may require the provision of additional information or representations in respect of certain such events. For this purpose,“control” is defined as the ability to direct the activities of a company other than any ability arising solely from serving as an officer or director of thecompany. A person is presumed to have control if such person holds 50% or more of the means of control of a company. “Means of control” refers to votingrights or the right to appoint directors or the chief executive officer. An “interested party” of a company includes a holder of 5% or more of its outstandingshare capital or voting rights, its chief executive officer and directors, someone who has the right to appoint its chief executive officer or at least one director,and a company with respect to which any of the foregoing interested parties holds 25% or more of the outstanding share capital or voting rights or has theright to appoint 25% or more of the directors. Failure to meet the R&D Law’s requirements may subject us to mandatory repayment of grants received by us (together with interest and penalties),as well as expose us to criminal proceedings. In addition, the Israeli government may from time to time audit sales of products which it claims incorporatetechnology funded through IIA programs which may lead to additional royalties being payable on additional products. Grants from Bio-Jerusalem The Bio-Jerusalem fund was founded by the Jerusalem Development Authority in order to support the biomed industry in Jerusalem. We arecommitted to pay royalties to the Bio-Jerusalem fund on proceeds from future sales at a rate of 4% and up to 100% of the amount of the grants received by theCompany (Israeli CPI linked) in the total aggregate amount of $65,000. We received no grants from the Bio-Jerusalem fund since the fiscal year endedAugust 31, 2013. As of August 31, 2017, we incurred a liability to pay royalties to the Bio-Jerusalem fund of $47,000. General and administrative expenses General and administrative expenses include the salaries and related expenses of our management, consulting costs, legal and professional fees,traveling, business development costs, insurance expenses and other general costs. General and administrative expenses increased by 12.5% from $2,452,000 for fiscal 2016 to $2,759,000 for fiscal 2017. The increase in costsincurred related to general and administrative activities during fiscal 2017, reflects an increase in stock-based compensation costs and salaries and consultingexpenses. During fiscal 2017, as part of our general and administrative expenses, we incurred $440,000 related to stock-based compensation costs, ascompared to $329,000 during fiscal 2016. General and administrative expenses decreased by 5.8% from $2,602,000 for fiscal 2015 to $2,452,000 for fiscal 2016. The decrease in costsincurred related to general and administrative activities during fiscal 2016, reflects a decrease in stock-based compensation costs that was partially offset byan increase in salaries and consulting expenses resulting from cash bonuses to employees and consultants paid in 2016. During fiscal 2016, as part of ourgeneral and administrative expenses, we incurred $329,000 related to stock-based compensation costs, as compared to $731,000 during fiscal 2015. 30  Financial income, net Net financial income was $691,000 for fiscal 2017 as compared to net financial income of $381,000 for fiscal 2016. The increase is mainly due to anincrease in income from bank deposits and held to maturity bonds as a result of the proceeds related to the License Agreement and due to an increase in yieldrates on investments. Net financial income was $381,000 for fiscal 2016 as compared to net financial income of $150,000 for fiscal 2015. The increase is mainly due to anincrease in income from bank deposits and held to maturity bonds as a result of the increase in cash and investment balances. Taxes on income / Tax benefit We had taxes on income of $400,000 for fiscal 2017 as compared to $1,335,000 for fiscal 2016. The decrease is due to a decrease in withholding taxdeducted from proceeds received related to the License Agreement, that resulted from a decrease in such proceeds. The Company estimates that withholdingtax will not be utilized in the next five years, and therefore was deducted. We had taxes on income of $1,335,000 for fiscal 2016 as compared to a tax benefit of $1,000 for fiscal 2015. The increase is due to withholding taxof $1,350,000 deducted from revenues received from the License Agreement, since according to the Company’s estimations, the withholding tax is notexpected to be utilized in the next five years. This deduction is partially offset by a decrease in the accrual for an uncertain tax position in fiscal 2016. Other comprehensive income Unrealized gain on available for sale securities for fiscal 2017 of $295,000 resulted from the increase in fair value of our D.N.A ordinary shares. Unrealized loss on available for sale securities for fiscal 2016 of $452,000 resulted from the decrease in fair value of our D.N.A ordinary shares. Liquidity and Capital Resources From our inception through August 31, 2017, we have incurred losses in an aggregate amount of $56,496,000. During that period we have financedour operations through several private placements of our common stock, as well as public offerings of our common stock, raising a total of $56,079,000, netof transaction costs. During that period we also received cash consideration of $4,880,000 from the exercise of warrants and options. We will seek to obtainadditional financing through similar sources in the future as needed. As of August 31, 2017, we had $3,969,000 of available cash, $29,525,000 of short termand long term deposits and investment and $5,011,000 of marketable securities. Management continues to evaluate various financing alternatives for funding future research and development activities and general andadministrative expenses through fundraising in the public or private equity markets. Although there is no assurance that we will be successful with thoseinitiatives, management believes that it will be able to secure the necessary financing as a result of future third party investments. Based on our current cashresources and commitments, we believe we will be able to maintain our current planned development activities and the corresponding level of expendituresfor at least the next 12 months and beyond. As of August 31, 2017, our total current assets were $20,297,000 and our total current liabilities were $5,165,000. On August 31, 2017, we had aworking capital surplus of $15,132,000 and an accumulated loss of $56,496,000. As of August 31, 2016, our total current assets were $31,230,000 and ourtotal current liabilities were $3,621,000. On August 31, 2016, we had a working capital surplus of $27,609,000 and an accumulated loss of $46,016,000. Thedecrease in working capital surplus from August 31, 2016 to August 31, 2017 was primarily due to the purchase of long-term bank deposits and due to thecash used in operating activities. 31  During fiscal 2017, cash and cash equivalents increased to $3,969,000 from $3,907,000 as of August 31, 2016, which is due to the reasons describedbelow. Operating activities used cash of $5,831,000 in fiscal 2017 compared to $4,655,000 provided in fiscal 2016. Cash used in operating activities infiscal 2017 primarily consisted of net loss resulting from research and development and general and administrative expenses, partially offset by changes instock-based compensation expenses and deferred revenues, while cash provided by operating activities in fiscal 2016 primarily consisted of changes indeferred revenues due to the License Agreement partially offset by net loss resulting from research and development and general and administrative expenses. Investing activities provided cash of $4,302,000 in fiscal 2017, as compared to $16,010,000 used in fiscal 2016. Cash provided by investingactivities in fiscal 2017 consisted primarily of the proceeds from sale of short-term deposits and maturity of marketable securities, partially offset by thepurchase of bank deposits and marketable securities, while cash used for investing activities in fiscal 2016 consisted primarily of the purchase of short-termand long-term bank deposits as well as the purchase of marketable securities. Financing activities provided cash of $1,586,000 in fiscal 2017 and $12,043,000 in fiscal 2016. Cash provided by financing activities during bothperiods consisted of proceeds from our issuance of common stock and proceeds from exercise of warrants and options. Our primary financing activities infiscal 2017 and fiscal 2016 were as follows: ●During fiscal 2017, 248,882 warrants were exercised for cash and resulted in the issuance of 248,882 shares of common stock and 63,900 options wereexercised for cash and resulted in the issuance of 63,900 shares of common stock. The cash consideration received for exercise of warrants was$1,242,000 and the cash consideration received for exercise of options was $319,000. During fiscal 2016, 331,054 warrants were exercised for cash andresulted in the issuance of 331,054 shares of common stock and 18,718 options were exercised for cash and resulted in the issuance of 18,718 shares ofcommon stock. The cash consideration received for exercise of warrants was $1,337,000 and the cash consideration received for exercise of options was$112,000. During fiscal 2017 and fiscal 2016, we issued a total of 23,750 shares of common stock to a third party vendor for services rendered. Theaggregate value of those shares was approximately $173,000. ●In November 2016 and February, May and August 2017, we issued a total of 10,000 shares of our common stock, valued at $72,000, in the aggregate, toa certain service provider as remuneration for services rendered. ●On November 30, 2015, we entered into the SPA with HTIT, pursuant to which HTIT agreed to buy and we agreed to sell 1,155,367 shares of ourcommon stock at a price of approximately $10.39 per share, for the aggregate amount of $12 million. The transaction closed on December 28, 2015. ●On April 2, 2015, we entered into an At The Market Issuance Sales Agreement and on April 5, 2017 into an amendment to such agreement, or the SalesAgreement, pursuant to which we may, from time to time and at our option, issue and sell shares of our common stock having an aggregate offering priceof up to $25,000,000, through a sales agent, subject to certain terms and conditions. Any shares sold will be sold pursuant to our effective shelfregistration statement on Form S-3 including a prospectus dated February 2, 2017, as supplemented by a prospectus supplement dated April 5, 2017. Wewill pay the sales agent a commission of 3.0% of the gross proceeds of the sale of any shares sold through the sales agent. As of August 31, 2017 andNovember 28, 2017, 2,970 and 456,889 shares, respectively, were sold under the Sales Agreement. 32  Contractual Obligations The following table summarizes our significant contractual obligations and commercial commitments at August 31, 2017, and the effects suchobligations are expected to have on our liquidity and cash flows in future periods (in thousands): Contractual Obligations Total Less than 1year 1-3 years 3-5 years Over 5 years Clinical research study obligations $2,166 $2,166 $- $- $- Purchase and technology transfer obligations 4,153 3,442 711 - - Operating lease obligations 168 47 81 40 - Royalty payment obligations 579 137 154 154 134 Accrued severance pay, net 18 - - - 18 Total $7,084 $5,792 $946 $194 $152 Off-Balance Sheet Arrangements As of August 31, 2017, we had no off balance sheet arrangements that have had or that we expect would be reasonably likely to have a futurematerial effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures orcapital resources. Planned Expenditures We invest heavily in research and development, and we expect that in the upcoming years our research and development expenses, net, willcontinue to be our major operating expense. ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK. We are exposed to a variety of risks, including changes in interest rates, foreign currency exchange rates, changes in the value of our marketablesecurities and inflation. As of August 31, 2017, we had $4 million in cash and cash equivalents, $29.5 million in short and long term bank deposits and restricted depositsand $5 million in marketable securities. We aim to preserve our financial assets, maintain adequate liquidity and maximize return while minimizing exposure to market risks. Such policyfurther provides that we should hold most of our current assets in bank deposits. As of today, the currency of our financial assets is mainly in U.S. dollars. Marketable securities We own 10,208,144 common shares of D.N.A, which are presented in our financial statements as marketable securities. Marketable securities arepresented at fair value and their realization is subject to certain limitations if sold through the market, and we are therefore exposed to market risk. There is noassurance that at the time of sale of the marketable securities the price per share will be the same or higher, nor that we will be able to sell all of the securitiesat once given the volume of securities we hold. The shares are traded on the Tel Aviv Stock Exchange and the shares' price is denominated in NIS. We arealso exposed to changes in the market price of D.N.A shares, as well as to exchange rates fluctuations in the NIS currency compared to the U.S. dollar. Interest Rate Risk We invest a major portion of our cash surplus in bank deposits in banks in Israel. Since the bank deposits typically carry fixed interest rates,financial income over the holding period is not sensitive to changes in interest rates, but only the fair value of these instruments. However, our interest gainsfrom future deposits may decline in the future as a result of changes in the financial markets. In any event, given the historic low levels of the interest rate, weestimate that a further decline in the interest rate we are receiving will not result in a material adverse effect to our business. Foreign Currency Exchange Risk and Inflation A significant portion of our expenditures, including salaries, clinical research expenses, consultants' fees and office expenses relate to our operationsin Israel. The cost of those Israeli operations, as expressed in U.S. dollars, is influenced by the extent to which any increase in the rate of inflation in Israel isnot offset (or is offset on a lagging basis) by a devaluation of the NIS in relation to the U.S. dollar. If the U.S. dollar declines in value in relation to the NIS, itwill become more expensive for us to fund our operations in Israel. In addition, as of August 31, 2017, we own net balances in NIS of approximately$1,150,000. Assuming a 10% appreciation of the NIS against the U.S. dollar, we would experience exchange rate gain of approximately $128,000, whileassuming a 10% devaluation of the NIS against the U.S. dollar, we would experience an exchange rate loss of approximately $105,000. 33  The exchange rate of the U.S. dollar to the NIS, based on exchange rates published by the Bank of Israel, was as follows: Year Ended August 31, 2017 2016 2015 Average rate for period 3.697 3.864 3.851 Rate at period-end 3.596 3.786 3.930 We do not use any currency hedging transactions of options or forwards to decrease the risk of financial exposure from fluctuations in the exchangerate of the U.S. dollar against the NIS. ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA. See Item 15 of this Annual Report on Form 10-K. ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE. None. ITEM 9A. CONTROLS AND PROCEDURES. Disclosure Controls and Procedures Our management, including our Chief Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls andprocedures as of August 31, 2017. Based upon that evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controlsand procedures are effective. Management’s Annual Report on Internal Control over Financial Reporting Our management, under the supervision of our Chief Executive Officer and Chief Financial Officer, is responsible for establishing and maintainingadequate internal control over our financial reporting, as defined in Rules 13a-15(f) and 15d-15(f) promulgated under the Exchange Act. The Company’sinternal control over financial reporting is defined as a process designed to provide reasonable assurance regarding the reliability of financial reporting andthe preparation of financial statements for external purposes in accordance with GAAP. Internal control over financial reporting includes policies andprocedures that: ●pertain to the maintenance of records that in reasonable detail accurately and fairly reflect our transactions and asset dispositions; ●provide reasonable assurance that transactions are recorded as necessary to permit the preparation of our financial statements in accordance withGAAP, and that our receipts and expenditures are being made only in accordance with authorizations of our management and directors; and ●provide reasonable assurance regarding the prevention or timely detection of unauthorized acquisition, use or disposition of assets that couldhave a material effect on our financial statements. Under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, weevaluated the effectiveness of our internal control over financial reporting as of August 31, 2017 based on the current framework for Internal Control-Integrated Framework (2013) set forth by The Committee of Sponsoring Organizations of the Treadway Commission. Based on this evaluation, our management concluded that the Company’s internal control over financial reporting was effective as of August 31,2017 at a reasonable assurance level. Changes in Internal Control over Financial Reporting There were no changes in our internal control over financial reporting that occurred during the quarter ended August 31, 2017 that have materiallyaffected, or are reasonable likely to materially affect, our internal control over financial reporting. ITEM 9B. OTHER INFORMATION. Not applicable. 34  PART III ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE. Set forth below is certain information with respect to the individuals who are our directors and executive officers. Name Age Position Nadav Kidron 43 President, Chief Executive Officer and Director Miriam Kidron 77 Chief Scientific Officer and Director Hilla Eisenberg 33 Chief Financial Officer, Treasurer and Secretary Joshua Hexter 47 Chief Operating Officer and VP Business Development Ronald Law 65 Chief Strategy Officer Aviad Friedman 46 Director Xiaopeng Li 33 Director Kevin Rakin 57 Director Leonard Sank 52 Director David Slager 45 Director Dr. Miriam Kidron is Mr. Nadav Kidron’s mother. There are no other directors or officers of the Company who are related by blood or marriage. Business Experience The following is a brief account of the education and business experience during at least the past five years of each director and our executiveofficers who are not also directors, indicating the principal occupation during that period, and the name and principal business of the organization in whichsuch occupation and employment were carried out. Mr. Nadav Kidron was appointed President, Chief Executive Officer and a director in March 2006. He is also a director of Israel AdvancedTechnology Industries organization, and until 2016 was a director of Entera Bio Ltd. In 2009, he was a fellow at the Merage Foundation for U.S.-Israel TradePrograms for executives in the life sciences field. From 2003 to 2006, he was the managing director of the Institute of Advanced Jewish Studies at Bar IlanUniversity. From 2001 to 2003, he was a legal intern at Wine, Mishaiker & Ernstoff Law Offices in Jerusalem, Israel. Mr. Kidron holds an LL.B. and anInternational MBA from Bar Ilan University, Israel, and is a member of the Israel Bar Association. We believe that Mr. Kidron’s qualifications to serve on our Board include his familiarity with the Company as its founder, his experience in capitalmarkets, as well as his knowledge and familiarity with corporate management. Dr. Miriam Kidron was appointed Chief Scientific Officer and a director in March 2006. Dr. Kidron is a pharmacologist and a biochemist with aPh.D. in biochemistry. From 1990 to 2007, Dr. Kidron was a senior researcher in the Diabetes Unit at Hadassah University Hospital in Jerusalem, Israel.During 2003 and 2004, Dr. Kidron served as a consultant to Emisphere Technologies Inc., a company that specializes in developing broad-based proprietarydrug delivery platforms. Dr. Kidron was formerly a visiting professor at the Medical School at the University of Toronto (Canada), and is a member of theAmerican, European and Israeli Diabetes Associations. Dr. Kidron is a recipient of the Bern Schlanger Award. 35  We believe that Dr. Kidron’s qualifications to serve on our Board include her expertise in the Company’s technology, as it is based on her research,as well as her experience and relevant education in the fields of pharmacology and diabetes. Ms. Hilla Eisenberg was appointed Chief Financial Officer, Treasurer and Secretary effective August 2017. Prior to her appointment, Ms.Eisenberg served as the Company’s Finance Manager from March 2016 until July 2017. Before joining the Company, Ms. Eisenberg provided audit andother accounting services at a certified public accounting firm in Israel. Prior to that, Ms. Eisenberg served as an auditor at PricewaterhouseCoopers in Israel,including a short secondment to PricewaterhouseCoopers in New York. Ms. Eisenberg holds a bachelor's degree in accounting and economics from Tel-AvivUniversity and is a certified public accountant in Israel. Mr. Joshua Hexter was appointed Chief Operating Officer and VP Business Development in April 2013. From 2007 to 2013, Mr. Hexter was aDirector or Executive Director in BioLineRx Ltd., or BioLineRx, a Tel-Aviv Stock Exchange-listed biopharmaceutical development company dedicated toidentifying, in-licensing and developing innovative therapeutic candidates. Prior to his employment with BioLineRx, Mr. Hexter was a member of the Boardof Directors and CEO of Biosensor Systems Design, Inc., a company developing market-driven biosensors. Mr. Hexter holds a bachelor’s degree from theUniversity of Wisconsin and a master’s degree in management from Boston University. Dr. Ronald Law was appointed Chief Strategy Officer in March 2017. From 2004 to 2016, Dr. Law served in several leadership and strategic roles inTakeda Pharmaceuticals Company Limited and its business divisions, where his latest role was Vice President, New Frontier Science, Chief Medical andScientific Officer in Takeda Pharmaceuticals International/Takeda Development Center, Americas. Dr. Law also served as the Consulting Head of BusinessDevelopment in PharmaIN Corporation in 2016 and currently serves as a consultant for other medical companies. Prior to joining Takeda PharmaceuticalsCompany Limited, Dr. Law was an Associate Professor of Medicine in the Endocrinology Division, University of California Los Angeles School of Medicine.Dr. Law received a Ph.D. in molecular biology from the University of California Los Angeles and a JD from the Whittier College School of Law. He is amember of the American Diabetes Association and the American Heart Association. Mr. Aviad Friedman became a director in August 2016. Mr. Friedman is an international businessman. Since 2007, he has been Chief ExecutiveOfficer of Most Properties 1998 Ltd. and the Chairman of the Israel Association of Community Centers since 2013. Mr. Friedman was the first DirectorGeneral of Israel's Ministry of Diaspora Affairs and served as personal advisor to Prime Minister Ariel Sharon from 1996 to 1999. Mr. Friedman served asChief Operating Officer of one of Israel’s premier newspapers, Ma'ariv from 2003 to 2007, and has more than 15 years of experience serving on boards ofpublic and private companies including Maayan Ventures, Capital Point and Rosetta Green Ltd. Mr. Friedman additionally served as an investor andconsultant at Rhythmia Medical Inc. from 2007, and was actively involved in the sale of the company to Boston Scientific in 2012. Mr. Friedman holds abachelor’s degree and master’s degree with honors in Public Administration from Bar-Ilan University. We believe that Mr. Friedman’s qualifications to serve on our Board include his experience in serving as a director of public and private companiesas well as his knowledge and familiarity with corporate finance. Ms. Xiaopeng Li became a director in January 2016. Ms. Li currently serves on the board of directors in the Chairman’s Office in Hefei TianmaiBiotechnology Development Co. Ltd, or HTBT, where she has served as the head of financing and investment activities since 2013. Ms. Li also has served asChief Financial Officer of Hi-Tech Brain Investment Company Limited, an affiliated company of HTBT, since 2015. Prior to that, she was a senior auditor inthe Shanghai Branch of Ernst & Young Hua Ming LLP, where she served for four years. Ms. Li holds a bachelor’s degree from the College of Economics,Anhui University, a Master of Accounting degree from Monash University, Australia, and a Master of Management degree from Central QueenslandUniversity, Australia. We believe that Ms. Li’s qualifications to serve on our Board include her experience and relevant education in the fields of finance, economics,capital markets and management, as well as her familiarity with the Eastern market. 36  Mr. Kevin Rakin became a director in August 2016 and Chairman of the Board in July 2017. Mr. Rakin is a co-founder and partner at HighCapePartners, a growth equity life sciences fund where he has served since 2013. From June 2011 to November 2012, Mr. Rakin was the President of RegenerativeMedicine at Shire plc, or Shire, a leading specialty biopharmaceutical company. Prior to joining Shire, Mr. Rakin served as the Chairman and ChiefExecutive Officer of Advanced BioHealing, Inc. from 2007 until its acquisition by Shire for $750 million in June 2011. Mr. Rakin currently serves on theboard of Histogenics Corporation. Mr. Rakin holds an MBA from Columbia University and received his graduate and undergraduate degrees in Commercefrom the University of Cape Town, South Africa. We believe that Mr. Rakin’s qualifications to serve on our Board include his extensive experience as an executive in the biotechnology industry, aswell as his service in positions in various companies as a chief executive officer, chief financial officer and president and his involvement in public andprivate financings and mergers and acquisitions in the biotechnology industry. Mr. Leonard Sank became a director in October 2007. Mr. Sank is a South African entrepreneur and businessman, whose interests lie inentrepreneurial endeavors and initiatives, with over 20 years' experience of playing significant leadership roles in developing businesses. For the pastseventeen years, Mr. Sank has served on the boards of a few businesses and local non-profit charity organizations in Cape Town, where he resides. We believe that Mr. Sank’s qualifications to serve on our Board include his years of experience in development stage businesses, as well as hisexperience serving as a director of many entities. Mr. David Slager became a director in August 2016. Mr. Slager is the founder and Chairman of Regals Capital, a New York based privateinvestment firm, and the Portfolio Manager of the fund. Prior to founding Regals Capital in 2012, Mr. Slager was the Chairman and the Portfolio Manager ofAttara Capital. Prior to Attara Capital in 2009, Mr. Slager was the Vice Chairman of Atticus Capital LP, a global investment management firm he joined in1998. Mr. Slager’s previous professional experience also includes having been in the Proprietary Equity Arbitrage Group at Goldman, Sachs & Co. in Londonand a financial analyst at Goldman, Sachs & Co. in New York and London. Mr. Slager holds a master’s degree in Legal Philosophy (Jurisprudence) fromOxford University. We believe that Mr. Slager’s qualifications to serve on our Board include his years of experience in the capital markets as well as his managementskills, his knowledge and familiarity with corporate finance and his familiarity with the Company given his history as a leading shareholder in the Company. Board of Directors There are no agreements with respect to the election of directors. Each director is elected for a period of one year at our annual meeting ofstockholders and serves until the next such meeting and until his or her successor is duly elected or until his or her earlier resignation or removal. The Boardmay also appoint additional directors. A director so chosen or appointed will hold office until the next annual meeting of stockholders and until his or hersuccessor is duly elected and qualified or until his or her earlier resignation or removal. The Board has determined that Leonard Sank, David Slager, KevinRakin, Aviad Friedman and Xiaopeng Li are independent as defined under the rules promulgated by the Nasdaq. Other than Mr. Slager, Ms. Li and Mr.Friedman, none of the independent directors has any relationship with us besides serving on our Board. In connection with a private placement of ourcommon stock in 2013, we have entered into a letter agreement with Mr. Slager pursuant to which we agreed not to issue stock options with an exercise pricebelow $6.00 per share and not to grant more than 125,000 stock options in any calendar year without the consent of certain stockholders. Ms. Li wasappointed to serve on our Board pursuant to the terms of the SPA dated November 30, 2015, but does not otherwise have any relationship with us. We hadentered into a consulting agreement with Shikma A.M.R. Ltd., or Shikma, of which Mr. Friedman is the sole owner, pursuant to which Shikma was granted anoption exercisable into shares of common stock of the Company as compensation for certain consulting services provided by Shikma to the Company. Thisconsulting agreement was terminated in August 2016. The Board considered these relationships and determined that they would not interfere with Mr.Slager’s, Ms. Li’s or Mr. Friedman’s exercise of independent judgment in carrying out the responsibilities of a director. 37  We have determined that each of the directors is qualified to serve as a director of the Company based on a review of the experience, qualifications,attributes and skills of each director. In reaching this determination, we have considered a variety of criteria, including, among other things: character andintegrity; ability to review critically, evaluate, question and discuss information provided, to exercise effective business judgment and to interact effectivelywith the other directors; and willingness and ability to commit the time necessary to perform the duties of a director. Board Meeting Attendance During fiscal 2017, our Board held 13 meetings and took actions by written consent on two occasions. Ms. Xiaopeng Li attended fewer than 75% ofthe aggregate of: (i) the total number of meetings of the Board (during the period for which such director served as a director); and (ii) the total number ofmeetings held by all committees of the Board on which such director served (during the period for which such director served on such committees). Boardmembers are encouraged to attend our annual meetings of stockholders. Committees Audit Committee and Audit Committee Financial Expert The members of our Audit Committee are Aviad Friedman, David Slager and Kevin Rakin. Our Board has determined that Aviad Friedman is an“audit committee financial expert” as set forth in Item 407(d)(5) of Regulation S-K and that all members of the Audit Committee are “independent” asdefined by the rules of the SEC and the Nasdaq rules and regulations. The Audit Committee operates under a written charter that is posted on the “Investors”section of our website, www.oramed.com. The primary responsibilities of our Audit Committee include: ●Overseeing the accounting and financial reporting processes of the Company and the audits of the financial statements of the Company; ●Appointing, compensating and retaining our registered independent public accounting firm; ●Overseeing the work performed by any outside accounting firm; ●Assisting the Board in fulfilling its responsibilities by reviewing: (i) the financial reports provided by us to the SEC, our stockholders or tothe general public, and (ii) our internal financial and accounting controls; and ●Recommending, establishing and monitoring procedures designed to improve the quality and reliability of the disclosure of our financialcondition and results of operations. Compensation Committee The members of our Compensation Committee are Leonard Sank, Kevin Rakin and Aviad Friedman. The Board has determined that all of themembers of the Compensation Committee are “independent” as defined by the rules of the SEC and Nasdaq rules and regulations. The CompensationCommittee operates under a written charter that is posted on the “Investors” section of our website, www.oramed.com. The primary responsibilities of ourCompensation Committee include: ●Reviewing, negotiating and approving, or recommending for approval by our Board the salaries and incentive compensation of ourexecutive officers; ●Administering our equity based plans and making recommendations to our Board with respect to our incentive-compensation plans andequity-based plans; and ●Making recommendations to our Board with respect to director compensation. 38  Nominating Committee The members of our Nominating Committee are Leonard Sank and Aviad Friedman. The Board has determined that all of the members of theNominating Committee are “independent” as defined by the rules of the SEC and Nasdaq rules and regulations. The Nominating Committee operates under awritten charter that is posted on the “Investors” section of our website, www.oramed.com. The primary responsibilities of our Nominating Committee include: ●Overseeing the composition and size of the Board, developing qualification criteria for Board members and actively seeking, interviewingand screening individuals qualified to become Board members for recommendation to the Board; ●Recommending the composition of the Board for each annual meeting of shareholders; and ●Reviewing periodically with the Chairman of the Board and the CEO the succession plans relating to positions held by directors, andmaking recommendations to the Board with respect to the selection and development of individuals to occupy those positions. Section 16(a) Beneficial Ownership Reporting Compliance Based solely upon a review of Forms 3, 4 and 5, and amendments thereto, furnished to us during fiscal 2017, we believe that during fiscal 2017, ourexecutive officers, directors and all persons who own more than ten percent of a registered class of our equity securities complied with all Section 16(a) filingrequirements, except: (a) Mr. Josh Hexter, our Chief Operating Officer, failed to timely file a Form 4 reporting his November 1, 2016 acquisition of 70,000shares of our common stock. Mr. Hexter filed a Form 4 reporting this transaction on November 22, 2016, (b) Mr. Kevin Rakin, one of our directors, failed totimely file a Form 4 reporting his February 9, 2017 acquisition of options to purchase 5,697 shares of our common stock. Mr. Rakin filed a Form 4 reportingthis transaction on February 16, 2017, (c) Mr. David Slager, one of our directors, failed to timely file a Form 4 reporting his February 9, 2017 acquisition ofoptions to purchase 5,697 shares of our common stock. Mr. Slager filed a Form 4 reporting this transaction on February 16, 2017, (d) Mr. Aviad Friedman, oneof our directors, failed to timely file a Form 4 reporting his February 9, 2017 acquisition of options to purchase 4,084 shares of our common stock. Mr.Friedman filed a Form 4 reporting this transaction on March 2, 2017 and (e) Ms. Xiaopeng Li, one of our directors, failed to timely file a Form 4 reporting herFebruary 9, 2017 acquisition of options to purchase 12,253 shares of our common stock. Ms. Li filed a Form 4 reporting this transaction on March 2, 2017. Code of Ethics We have adopted a Code of Ethics and Business Conduct for our senior officers, directors and employees. A copy of the Code of Ethics and BusinessConduct is located at our website at www.oramed.com. We intend to satisfy the disclosure requirement regarding any amendment to, or a waiver from, aprovision of the Code of Ethics that applies to our Chief Executive Officer, or CEO, Chief Financial Officer, or CFO, or controller, or persons performingsimilar functions and that relates to the Code of Ethics by posting such information on our website, www.oramed.com. ITEM 11. EXECUTIVE COMPENSATION. Compensation Discussion and Analysis This section explains the policies and decisions that shape our executive compensation program, including its specific objectives and elements, as itrelates to our “named executive officers,” or NEOs. Our NEOs for fiscal 2017 are those three individuals listed in the “Summary Compensation Table” below.The Compensation Committee believes that our executive compensation is appropriately designed to incentivize our named executive officers to work forour long-term prosperity, is reasonable in comparison with the levels of compensation provided by comparable companies, and reflects a reasonable cost. Webelieve our named executive officers are critical to the achievement of our corporate goals, through which we can drive stockholder value. The Compensation Committee of our Board is comprised solely of independent directors as defined by NASDAQ and non-employee directors asdefined by Rule 16b-3 under the Exchange Act. The Compensation Committee has the authority and responsibility to review and approve the compensationof our CEO and other executive officers. Other information concerning the structure, roles and responsibilities of our Compensation Committee is set forth in"Board Meetings and Committees—Compensation Committee" section. 39  Our executive compensation program and our NEOs’ compensation packages are designed around the following objectives: ●attract, hire, and retain talented and experienced executives; ●motivate, reward and retain executives whose knowledge, skills and performance are critical to our success; ●ensure fairness among the executive management team via recognizing the contributions of each executive to our success; ●focus executive behavior on achievement of our corporate objectives and strategy; and ●align the interests of management and stockholders by providing management with longer-term incentives through equity ownership. The Compensation Committee reviews the allocation of compensation components regularly to ensure alignment with strategic and operating goals,competitive market practices and legislative changes. The Compensation Committee does not apply a specific formula to determine the allocation betweencash and non-cash forms of compensation. Certain compensation components, such as base salaries, benefits and perquisites, are intended primarily to attract,hire, and retain well-qualified executives. Other compensation elements, such as long-term incentive opportunities, are designed to motivate and rewardperformance. Long-term incentives are intended to reward NEOs for our long-term performance and executing our business strategy, and to strongly alignNEOs' interests with those of stockholders. With respect to equity compensation, the Compensation Committee makes awards to executives under our Second Amended and Restated 2008Stock Incentive Plan, or 2008 Plan. Executive compensation is paid or granted based on such matters as the Compensation Committee deems appropriate,including our financial and operating performance and the alignment of the interests of the executive officers and our stockholders. Elements of Compensation Our executive officer compensation program is comprised of: (i) base salary or monthly compensation; (ii) discretionary bonus; (iii) long-termequity incentive compensation in the form of stock option and RSU grants; and (iv) benefits and perquisites. In establishing overall executive compensation levels and making specific compensation decisions for our NEOs in fiscal 2017, the CompensationCommittee considered a number of criteria, including the executive's position, scope of responsibilities, prior base salary and annual incentive awards andexpected contribution. Generally, our Compensation Committee reviews and, as appropriate, approves compensation arrangements for the NEOs from time to time but notless than once each year. The Compensation Committee also takes into consideration the CEO's recommendations for executive compensation of the otherthree NEOs. The CEO generally presents these recommendations at the time of our Compensation Committee's review of executive compensationarrangements. Base Salary The Compensation Committee performs a review of base salaries and monthly compensation for our NEOs from time to time as appropriate. Indetermining salaries, the Compensation Committee members also take into consideration the scope of the NEOs' responsibilities and independent third partymarket data, such as compensation surveys to industry, individual experience and performance and contribution to our clinical, regulatory, commercial andoperational performance. None of the factors above has a dominant weight in determining the compensation of our named executive officers, and ourCompensation Committee considers the factors as a whole when considering such compensation. In addition, our Compensation Committee usescomparative data regarding compensation paid by peer companies in order to obtain a general understanding of current trends in compensation practices andranges of amounts being awarded by other public companies, and not as part of an analysis or a formula. 40  In fiscal 2017, for example, the Compensation Committee received consulting services from Aon Consulting, Inc., or Aon, through its Radfordsubdivision (part of Aon Hewitt), or Radford, with regard to management and Board compensation. The Compensation Committee engaged the consultantsolely to collect and analyze data regarding management and Board compensation at other companies comparable to the Company. The consultant collecteddata regarding U.S. and Israeli practices, reviewed executive compensation against a market composite of peer proxy data and Radford survey data,determined the U.S. to Israeli discount and applied the discount to position specific U.S. data to arrive at Israeli market data. The Israeli peer group consisted of the following companies: Alcobra Ltd., BioLine Rx Ltd., Can-Fite BioPharma Ltd., Foamix Pharmaceuticals Ltd.,Galmed Pharmaceuticals Ltd., Intec Pharma Ltd., Kamada Ltd., MediWound Ltd., Pluristem Therapeutics Inc., Protalix BioTherapeutics Inc., RedHillBiopharma Ltd. and Vascular Biogenics Ltd. The U.S. peer group consisted of the following companies: Actinium Pharmaceuticals Inc., Athersys Inc.,Capricor Therapeutics Inc., Cara Therapeutics Inc., Catabasis Pharmaceuticals Inc., Cymabay Therapeutics Inc., Eiger BioPharmaceuticals Inc., ElevenBiotherapeutics Inc., Endocyte Inc., Genocea Biosciences Inc., GlycoMimetics Inc., GTx Inc., Kura Oncology Inc., Ocera Therapeutics Inc., StemlineTherapeutics Inc., Tracon Pharmaceuticals Inc. and vTv Therapeutics Inc. The Compensation Committee did not receive any executive compensation consulting services in fiscal 2016 and fiscal 2015. We believe that a competitive base salary and monthly compensation is a necessary element of any compensation program that is designed to attractand retain talented and experienced executives. We also believe that attractive base salaries can motivate and reward executives for their overall performance.Base salary and monthly compensation are established in part based on the individual experience, skills and expected contributions to our performance, aswell as such executive’s performance during the prior year. Generally, we believe that executives' base salaries should be targeted near the median of therange of salaries for executives in similar positions with similar responsibilities, experience and performance at comparable companies. Compensationadjustments are made occasionally based on changes in an executive's level of responsibility, company progress or on changed local and specific executiveemployment market conditions. In fiscal 2017, our Compensation Committee increased the base salaries of our NEOs by ten to thirty three percent based on the report from Aon, as itdetermined salaries were not in line with market, and in fiscal 2016, our Compensation Committee increased the base salaries of our NEOs by ten to twentypercent, as it deemed this to be a reasonable rate in the biotechnology industry. Performance Based Bonus Our NEOs are eligible to receive discretionary annual bonuses based upon performance. The amount of annual bonus to our NEOs is based onvarious factors, including, among others, the achievement of scientific and business goals and our financial and operational performance. The CompensationCommittee takes into account the overall performance of the individuals, as well as the overall performance of the Company over the period being reviewedand the recommendation of management. For any given year, the compensation objectives vary, but relate generally to strategic factors such as developmentsin our clinical path, the execution of a license agreement for the commercialization of product candidates, the establishment of key strategic collaborations,the build-up of our pipeline and financial factors such as capital raising. Bonuses are awarded generally based on corporate performance, with adjustmentsmade within a range for individual performance, at the discretion of the Compensation Committee. The Compensation Committee determines, on adiscretionary basis, the size of the entire bonus pool and the amount of the actual award to each NEO. The overall payment is also based on historiccompensation of the NEOs. We believe that annual bonuses payable based on the achievement of short-term corporate goals incentivize our NEOs to create stockholder value andattain short-term performance objectives. 41  Long-Term Equity Incentive Compensation Long-term incentive compensation allows the NEOs to share in any appreciation in the value of our common stock. The Compensation Committeebelieves that stock participation aligns executive officers’ interests with those of our stockholders. Equity incentive awards are generally made at thecommencement of employment and following a significant change in job responsibilities, or to meet other special retention or performance objectives. Theamounts of the awards are designed to reward past performance and create incentives to meet long-term objectives. Awards are made at a level expected to becompetitive within the biotechnology industry, as well as with Israeli-based companies. Awards are made on a discretionary basis and not pursuant to specificcriteria set out in advance. In determining the amount of each grant, the Compensation Committee also takes into account the number of shares held by theexecutive prior to the grant. The vesting schedule for NEOs was based on monthly installments for periods of no longer than three years through thebeginning of fiscal 2017; however, following consultation with Aon during fiscal 2017, the vesting schedule for NEOs was moved to annual installments fornew grants. The Compensation Committee believes that time-based vesting encourages recipients to build stockholder value over a long period of time. RSU awards provide our NEOs with the right to purchase shares of our common stock at a par value of $0.012, subject to continued employmentwith our company. In November 2014, the Compensation Committee awarded RSUs for the first time and again awarded RSUs in February 2015 and inNovember 2016. We chose to grant RSU awards and not options because RSU awards, once vested, always have an immediate financial value to the holderthereof, unlike options where the exercise price might be above the current market price of the shares and therefore not have any intrinsic value to the holderthereof. In addition, because vested RSU awards always have financial value, as opposed to options, we were able to limit the number of securities issued toour NEOs and other employees, directors and consultants. RSUs generally vest over a period of no longer than two years. In June 2017, followingconsultation with Aon, the Compensation Committee chose to grant options instead of RSUs and in addition granted to the CEO options with a marketcondition of our share price reaching a certain target, in order to further strengthen the alignment of our NEOs’ interests with those of our stockholders, as partof our efforts to increase the Company's market value. The Compensation Committee believes that time-based vesting encourages recipients to buildstockholder value over a long period of time. Benefits and Perquisites Generally, benefits available to NEOs are available to all employees on similar terms and include welfare benefits, paid time-off, life and disabilityinsurance and other customary or mandatory social benefits in Israel. We provide our NEOs with a phone and a company car, which are customary benefits inIsrael to managers and officers. During fiscal 2017, the Compensation Committee approved the payment to Mr. Kidron of approximately $7,600 per month for a period beginningin August 2017, during which Mr. Kidron is in the United States. This payment replaced per diem payments for such business travel. The CompensationCommittee determined that this amount reflects the difference in the cost of living between Israel and the United States. We do not believe that the benefits and perquisites described above deviate materially from the customary practice for compensation of executiveofficers by other companies similar in size and stage of development in Israel. These benefits represent a relatively small portion of the executive officers'total compensation. Say-on-Pay Vote Our stockholders approved, on an advisory basis, our executive compensation program at our 2016 Annual Meeting. We did not seek or receive anyspecific feedback from our stockholders concerning our executive compensation program during the past fiscal year. The Compensation Committee did notspecifically rely on the results of the prior vote in making any compensation-related decisions during fiscal 2017. 42  COMPENSATION COMMITTEE REPORT The Compensation Committee has reviewed and discussed the foregoing Compensation Discussion and Analysis required by Item 402(b) ofRegulation S-K with our management and, based on such review and discussions, the Compensation Committee recommended to our Board that theCompensation Discussion and Analysis be included in this Annual Report on Form 10-K and in our proxy statement relating to our next annual meeting ofstockholders. Compensation Committee Members: Aviad FriedmanKevin RakinLeonard Sank SUMMARY COMPENSATION TABLE The following table sets forth the compensation earned by our NEOs for fiscals 2017, 2016 and 2015. Name and PrincipalPosition Year(1) Salary($)(2) Bonus($)(2)(3) Stock Awards($)(4) OptionAwards($)(5) All OtherCompensation($)(2)(6) Total($) Nadav Kidron 2017 399,804 123,000 - 585,150 45,579 1,153,533 President and CEO and 2016 273,086 195,729 - - 17,366 486,181 director (7) 2015 254,318 63,045 431,645 - 16,217 765,225 Miriam Kidron 2017 254,765 50,000 581,932 359,224 12,775 1,258,696 Chief Scientific Officer 2016 203,378 136,583 - - 13,191 353,152 and director (8) 2015 188,466 50,436 431,645 - 13,592 684,139 Joshua Hexter 2017 148,499 33,000 463,400 - 46,408 691,307 COO and VP Business 2016 132,306 86,974 - - 42,014 261,294 Development 2015 124,108 32,363 - - 39,547 196,018 (1)The information is provided for each fiscal year, which begins on September 1 and ends on August 31. (2)Amounts paid for Salary, Bonus and All Other Compensation were originally denominated in NIS and were translated into U.S. dollars at the thencurrent exchange rate for each payment. (3)Bonuses were granted at the discretion of the Compensation Committee. (4)For RSU awards, the amounts reflect the grant date fair value, as calculated pursuant to FASB ASC Topic 718. The assumptions used to determinethe fair value of the RSU awards are set forth in Note 8 to our audited consolidated financial statements included in this Annual Report on Form 10-K. Our NEOs will not realize the value of these awards in cash unless and until the awards vest and the underlying shares are issued and subsequentlysold. (5)The amounts reflect the grant date fair value, as calculated pursuant to FASB ASC Topic 718, of these option awards. The assumptions used todetermine the fair value of the option awards are set forth in Note 8 to our audited consolidated financial statements included in this Annual Reporton Form 10-K. Our NEOs will not realize the value of these awards in cash unless and until these awards are exercised and the underlying sharessubsequently sold. (6)See “All Other Compensation Table” below. (7)Mr. Kidron receives compensation from Oramed Ltd. through KNRY, Ltd., an Israeli entity owned by Mr. Kidron, or KNRY. See “—Employment andConsulting Agreements” below. (8)Dr. Kidron receives compensation from Oramed Ltd. through KNRY. See “—Employment and Consulting Agreements” below. 43  All Other Compensation Table The “All Other Compensation” amounts set forth in the Summary Compensation Table above consist of the following: Name Year Automobile-RelatedExpenses($) Manager’sInsurance*($) EducationFund*($) BusinessTravel**($) Total($) Nadav Kidron 2017 28,098 - - 17,481 45,579 2016 17,366 - - - 17,366 2015 16,217 - - - 16,217 Miriam Kidron 2017 12,775 - - - 12,775 2016 13,191 - - - 13,191 2015 13,592 - - - 13,592 Joshua Hexter 2017 12,910 22,513 10,985 - 46,408 2016 12,660 19,585 9,769 - 42,014 2015 12,451 18,030 9,066 - 39,547 *Manager’s insurance and education funds are customary benefits provided to employees based in Israel. Manager’s insurance is a combination ofseverance savings (in accordance with Israeli law), defined contribution tax-qualified pension savings and disability insurance premiums. Aneducation fund is a savings fund of pre-tax contributions to be used after a specified period of time for educational or other permitted purposes. **Business travel represents additional compensation in fiscal 2017, for the period during which Mr. Kidron was in the United States. Employment and Consulting Agreements On July 1, 2008, Oramed Ltd. entered into a consulting agreement with KNRY, whereby Mr. Nadav Kidron, through KNRY, provides services asPresident and Chief Executive Officer of both the Company and Oramed Ltd., or the Nadav Kidron Consulting Agreement. Additionally, on July 1, 2008,Oramed Ltd. entered into a consulting agreement with KNRY whereby Dr. Miriam Kidron, through KNRY, provides services as Chief Scientific Officer ofboth the Company and Oramed Ltd., or the Miriam Kidron Consulting Agreement. We refer to the Miriam Kidron Consulting Agreement and Nadav KidronConsulting Agreement collectively as the Consulting Agreements. The Consulting Agreements are both terminable by either party upon 60 days prior written notice. The Consulting Agreements, as amended, providethat KNRY will be reimbursed for reasonable expenses incurred in connection with performance of the Consulting Agreements and that Nadav Kidronreceives a monthly consulting fee of NIS 127,570 and Miriam Kidron receives a monthly consulting fee of NIS 80,454. Pursuant to the ConsultingAgreements, KNRY, Nadav Kidron and Miriam Kidron each agree that during the term of the Consulting Agreements and for a 12 month period thereafter,none of them will compete with Oramed Ltd. nor solicit employees of Oramed Ltd. 44  We, through Oramed Ltd., have entered into an employment agreement with Joshua Hexter as of April 14, 2013, pursuant to which Mr. Hexter wasappointed as Chief Operating Officer and VP Business Development of the Company and Oramed Ltd. In accordance with the employment agreement, asamended, Mr. Hexter’s current gross monthly salary is NIS 44,891. In addition, Mr. Hexter is provided with a cellular phone and a company car pursuant tothe terms of his agreement. We, through Oramed Ltd., have entered into a consulting agreement with Ronald Law as of March 1, 2017, pursuant to which Dr. Law was appointedas Chief Strategy Officer of the Company and Oramed Ltd., effective March 20, 2017. In accordance with the consulting agreement, Dr. Law’s currentmonthly consulting fee is $10,000. In addition, Dr. Law is entitled to a reimbursement of his communication expenses. We, through Oramed Ltd., have entered into an employment agreement with Hilla Eisenberg as of July 20, 2017, pursuant to which Ms. Eisenbergwas appointed as Chief Financial Officer, Treasurer and Secretary of the Company and Oramed Ltd., effective August 1, 2017. In accordance with theemployment agreement, Ms. Eisenberg’s current gross monthly salary is NIS 34,000. In addition, Ms. Eisenberg is provided with a cellular phone and travelreimbursement pursuant to the terms of her agreement. We have entered into indemnification agreements with our directors and officers pursuant to which we agreed to indemnify each director and officerfor any liability he or she may incur by reason of the fact that he or she serves as our director or officer, to the maximum extent permitted by law. Potential Payments upon Termination or Change-in-Control We have no plans or arrangements in respect of remuneration received or that may be received by our named executive officers to compensate suchofficers in the event of termination of employment (as a result of resignation, retirement, change-in- control) or a change of responsibilities following achange-in-control. Pension, Retirement or Similar Benefit Plans We have no arrangements or plans under which we provide pension, retirement or similar benefits for directors or executive officers. Our directorsand executive officers may receive stock options, RSUs or restricted shares at the discretion of our Compensation Committee in the future. 45  GRANTS OF PLAN-BASED AWARDS The following table shows grants of plan-based equity awards made to our NEOs during fiscal 2017: Name Grant Date OptionsAwards:Number ofSecuritiesUnderlyingOptions(#) All OtherStock Awards:Number ofSecuritiesUnderlyingRSUs(#) Grant DateFair Value ofStock Awards($) Nadav Kidron(1) 6/30/17 147,000 - 585,150 Miriam Kidron(2) 6/30/17 69,999 - 359,224 Miriam Kidron(3) 6/30/17 - 75,000 581,932 Joshua Hexter(4) 11/1/2017 - 70,000 463,400 (1)These options were granted under our 2008 Plan and vest in 3 equal installments of 49,000 on each of December 31, 2017, December 31, 2018and December 31, 2019, subject to the Company share price reaching the target of $8.00, $9.50 and $12.50 per share, respectively. (2)These options were granted under our 2008 Plan and vest in 3 equal installments of 23,333 on each of December 31, 2017, December 31, 2018and December 31, 2019. (3)These RSUs were granted under our 2008 Plan, vested immediately and are issuable upon request. (4)These RSUs were granted under our 2008 Plan and vest as follows: 9,000 shares vested immediately; 1,500 shares will vest in 18 consecutiveinstallments on the last day of each month commencing November 30, 2016; and 17,000 will vest in each of April 30, 2017 and April 30, 2018. 46  OUTSTANDING EQUITY AWARDS AT FISCAL YEAR-END The following table sets forth information concerning stock options and stock awards held by the NEOs as of August 31, 2017. Option Awards Stock Awards Name Number ofSecuritiesUnderlyingUnexercisedOptions (#)Exercisable Number ofSecuritiesUnderlyingUnexercisedOptions (#)Unexercisable OptionExercisePrice($) OptionExpirationDate Number ofshares thathave notvested (#) Market valueof shares thathave notvested ($) Nadav Kidron 72,000(1) - 6.48 5/7/18 72,000(2) - 5.88 4/20/20 72,000(3) - 4.08 8/8/22 47,134(4) - 12.45 4/9/24 - 147,000(5) 7.77 6/30/27 -(8)(9) - Miriam Kidron 72,000(1) - 6.48 5/7/18 72,000(2) - 5.88 4/20/20 72,000(3) - 4.08 8/8/22 47,134(4) - 12.45 4/9/24 69,999(6) 7.77 6/30/27 -(10) - Joshua Hexter 100,800(7) - 7.88 3/14/23 29,000(11) 250,850 (1)On May 7, 2008, 72,000 options were granted to each of Nadav Kidron and Miriam Kidron under the 2008 Plan at an exercise price of $6.48 pershare; 12,000 of such options vested immediately on the date of grant and the remainder vested in twenty equal monthly installments, commencingon June 30, 2008. The options have an expiration date of May 7, 2018. (2)On April 21, 2010, 72,000 options were granted to each of Nadav Kidron and Miriam Kidron under the 2008 Plan at an exercise price of $5.88 pershare; 9,000 of such options vested immediately on the date of grant and the remainder vested in twenty-one equal monthly installments,commencing on May 31, 2010. The options have an expiration date of April 20, 2020. (3)On August 8, 2012, 72,000 options were granted to each of Nadav Kidron and Miriam Kidron under the 2008 Plan at an exercise price of $4.08 pershare; 21,000 of such options vested immediately on the date of grant and the remainder vested in seventeen equal monthly installments,commencing on August 31, 2012. The options have an expiration date of August 8, 2022. (4)On April 9, 2014, 47,134 options were granted to each of Nadav Kidron and Miriam Kidron under the 2008 Plan at an exercise price of $12.45 pershare; 15,710 of such options vested on April 30, 2014 and the remainder vested in eight equal monthly installments, commencing on May 31,2014. The options have an expiration date of April 9, 2024. (5)On June 30, 2017, 147,000 options were granted to Nadav Kidron under the 2008 Plan at an exercise price of $7.77 per share; Such options vest in 3equal installments of 49,000 on each of December 31, 2017, December 31, 2018 and December 31, 2019, subject to the Company share pricereaching the target of $8.0, $9.5 and $12.5 per share, respectively. The options have an expiration date of June 30, 2027. 47  (6)On June 30, 2017, 147,000 options were granted to Miriam Kidron under the 2008 Plan at an exercise price of $7.77 per share; the options vest in 3equal installments of 23,333 on each of December 31, 2017, December 31, 2018 and December 31, 2019. The options have an expiration date ofJune 30, 2027. (7)On April 14, 2013, 100,800 options were granted to Joshua Hexter under the 2008 Plan at an exercise price of $7.88 per share; the options vested in35 consecutive equal installments during a 3-year period commencing on May 31, 2013, and two installments of 1,400 each, that were vested onApril 30, 2013 and April 14, 2016, and expire on April 14, 2023. (8)On November 13, 2014, 9,788 RSUs, representing a right to receive shares of the Company’s common stock, were granted to Nadav Kidron. TheRSUs vested in two equal installments, each of 4,894 shares, on November 30 and December 31, 2014. The shares of common stock underlying theRSUs will be issued upon request of the grantee. (9)On February 23, 2015, 79,848 RSUs, representing a right to receive shares of the Company’s common stock, were granted to Nadav Kidron. TheRSUs vested in 23 installments consisting of one installment of 6,654 shares on February 28, 2015 and 22 equal monthly installments of 3,327shares each, commencing March 31, 2015. The shares of common stock underlying the RSUs will be issued upon request of the grantee. (10)On June 30, 2016, 75,000 RSUs, representing a right to receive shares of the Company’s common stock, were granted to Miriam Kidron. The RSUsvested immediately and according to a further resolution of the compensation committee dated September 26, 2017, have an exercise price of$0.012 per share of common stock and expire on June 30, 2017. (11)On November 1, 2016, 70,000 RSUs, representing a right to receive shares of the Company’s common stock, were granted to Joshua Hexter. TheRSUs vest in 19 installments, consisting of one installment of 9,000 shares on November 1, 2016, 18 equal monthly installments of 1,500 shareseach, commencing November 30, 2016, and 17,000 shares on each of April 30, 2017 and 2018. OPTIONS EXERCISED AND STOCK VESTED The following table sets forth information with respect to the NEOs concerning the vesting of RSUs during fiscal 2017. No options were exercisedby the NEOs in fiscal 2017. Stock Awards Name Number ofSharesAcquired onVesting (#) ValueRealized onVesting ($) Joshua Hexter 41,000 298,430 Nadav Kidron 13,308(1) 87,034(2)Miriam Kidron 88,308(1) 668,966(2) (1)Represents shares of common stock not yet issued underlying RSUs that have vested. Such shares will be issued upon request of the grantee. (2)Represents the value of shares of common stock not yet issued underlying RSUs that have vested. Such shares will be issued upon request of the grantee. Compensation Committee Interlocks and Insider Participation During fiscal 2017, Mr. Aviad Friedman, Mr. Kevin Rakin and Mr. Leonard Sank served as the members of our Compensation Committee. None ofthe members of our Compensation Committee is, or has been, an officer or employee of ours. 48  During the last year, none of our NEOs served as: (1) a member of the compensation committee (or other committee of the Board performingequivalent functions or, in the absence of any such committee, the entire board of directors) of another entity, one of whose executive officers served on thecompensation committee; (2) a director of another entity, one of whose executive officers served on the compensation committee; or (3) a member of thecompensation committee (or other committee of the board of directors performing equivalent functions or, in the absence of any such committee, the entireboard of directors) of another entity, one of whose executive officers served as a director on our Board. DIRECTOR COMPENSATION The following table provides information regarding compensation earned by, awarded or paid to each person for serving as a director who is not anexecutive officer during fiscal 2017: Name of Director FeesEarned orPaid inCash($) Stock Awards(2)($) OptionAwards (3)($) All OtherCompensation($) Total($) Nadav Kidron (1) - - - - - Miriam Kidron (1) - - - - - Leonard Sank 20,000 - 86,076 - 106,076 Xiaopeng Li 20,000 - 153,909 - 173,909 Aviad Friedman 20,000 - 108,685 - 128,685 Kevin Rakin 20,000 - 316,406 - 336,406 David Slager 20,000 - 108,460 - 128,460 (1) Please refer to the Summary Compensation Table for executive compensation with respect to the named individual. (2) As of August 31, 2017, our non-employee directors then in office held options and unvested RSUs to purchase shares of our common stock as follows: Name of Director AggregateNumberof SharesUnderlyingStockAwards Leonard Sank 74,867 David Slager 22,470 Aviad Friedman 20,857 Kevin Rakin 62,470 Xiaopeng Li 29,026 (3) The amounts reflect the grant date fair value, as calculated pursuant to FASB ASC Topic 718, of these option awards. The assumptions used todetermine the fair value of the option awards are set forth in Note 8 to our audited consolidated financial statements included in this Annual Report on Form10-K. Our directors will not realize the value of these awards in cash unless and until these awards are exercised and the underlying shares subsequently sold. Our directors are entitled to reimbursement for reasonable travel and other out-of-pocket expenses incurred in connection with attendance atmeetings of our Board. Each independent director is entitled to receive as remuneration for his or her service as a member of the Board a sum equal to$20,000 per annum, to be paid quarterly and shortly after the close of each quarter. Our executive officers did not receive additional compensation for serviceas directors. The Board may award special remuneration to any director undertaking any special services on behalf of us other than services ordinarilyrequired of a director. 49  Other than as described above, we have no present formal plan for compensating our directors for their service in their capacity as directors. Otherthan indicated above, no director received and/or accrued any compensation for his services as a director, including committee participation and/or specialassignments during fiscal 2017. ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS. Stock Option Plans Our Board adopted the 2008 Plan in order to attract and retain quality personnel. The 2008 Plan provides for the grant of stock options, restrictedstock, RSUs, and stock appreciation rights, collectively referred to as “awards.” Stock options granted under the 2008 Plan may be either incentive stockoptions under the provisions of Section 422 of the Internal Revenue Code, or non-qualified stock options. Under the 2008 Plan, as amended, 2,400,000shares were reserved for the grant of awards, which may be issued at the discretion of our Board from time to time. The 2008 Plan permits awards to be basedon performance-based criteria that will allow us to maximize its ability to pay deductible compensation for U.S. federal income tax purposes. As of August31, 2017, options with respect to 1,870,848 shares have been granted, of which 12,297 have been forfeited, 119,224 have been exercised and 475,292 haveexpired. As of August 31, 2017, 525,824 RSUs have been granted, of which 294,300 have vested and the shares of common stock underlying RSUs wereissued, 164,636 have vested and the shares of common stock underlying those RSUs will be issued upon request of the grantee and 33,248 have beenforfeited. The following table sets forth additional information with respect to our equity compensation plans (consisting solely of the 2008 Plan) as of August31, 2017: Plan category Number ofsecurities tobe issueduponexercise ofoutstandingoptions, warrantsand rights(a) Weight-averageexerciseprice ofoutstandingoptions, warrantsand rights(b) Number ofsecuritiesremainingavailable forfutureissuanceunder equitycompensationplans(excludingsecuritiesreflected incolumn (a))(c) Equity compensation plans approved by security holders 1,001,041 $5.47 524,165 Equity compensation plans not approved by security holders - - - Total 1,001,041 $5.47 524,165 Security Ownership of Certain Beneficial Owners and Management The following table sets forth certain information regarding the beneficial ownership of our common stock as of November 28, 2017 by: (1) eachperson who is known by us to own beneficially more than 5% of our common stock; (2) each director; (3) each of our NEOs listed above under “SummaryCompensation Table”; and (4) all of our directors and executive officers as a group. On such date, we had 14,306,100 shares of common stock outstanding. As used in the table below and elsewhere in this form, the term “beneficial ownership” with respect to a security consists of sole or shared votingpower, including the power to vote or direct the vote, and/or sole or shared investment power, including the power to dispose or direct the disposition, withrespect to the security through any contract, arrangement, understanding, relationship, or otherwise, including a right to acquire such power(s) during thenext 60 days following November 28, 2017. Inclusion of shares in the table does not, however, constitute an admission that the named stockholder is a director indirect beneficial owner of those shares. Unless otherwise indicated, (1) each person or entity named in the table has sole voting power and investmentpower (or shares that power with that person’s spouse) with respect to all shares of common stock listed as owned by that person or entity and (2) the addressof each of the individuals named below is: c/o Oramed Pharmaceuticals Inc., Hi-Tech Park 2/4 Givat Ram, PO Box 39098, Jerusalem 91390, Israel. 50  Name and Address of Beneficial Owner Number ofShares Percentageof SharesBeneficiallyOwned Regals Fund LP 152 West 57th Street, 9th Floor New York, NY 10019 1,316,328(1) 8.6%HTITNo. 199 Fanhua RoadEconomic and Technological Development ZoneHeifei, Anhui Province, P.R. China, Zip Code: 230601 1,155,367(2) 7.5%Nadav Kidron #+ 2,631,999(3) 17.3%Miriam Kidron #+ 361,467(4) 2.4%Joshua Hexter + 147,800(5) 1%Aviad Friedman # 29,366(6) * Xiaopeng Li # 224,194(7) * Kevin Rakin # 36,349(8) * Leonard Sank # 574,861(9) 3.8%David Slager # 1,327,616(10) 8.7%All current executive officers and directors, as a group (ten persons) 5,151,949(11) 33.6% *Less than 1%#Director+NEO (1)Regals Capital Management LP, or Regals Management, is the investment manager of Regals Fund LP, the owner of record of these shares ofcommon stock. Mr. David Slager is the managing member of the general partner of Regals Management. All investment decisions are made by Mr.Slager, and thus the power to vote or direct the votes of these shares of common stock, as well as the power to dispose or direct the disposition ofsuch shares of common stock is held by Mr. Slager through Regals Management. (2)Based solely on a Schedule 13D filed by HTIT on January 6, 2016. On November 30, 2015, we entered into a securities purchase agreement withHTIT pursuant to which, among other things, Nadav Kidron will serve as proxy and attorney in fact of HTIT, with full power of substitution, to caston behalf of HTIT all votes that HTIT is entitled to cast with respect to 1,155,367 shares of common stock, or the Purchased Shares, at any and allmeetings of our shareholders, to consent or dissent to any action taken without a meeting and to vote all the Purchased Shares held by HTIT in anymanner Mr. Kidron deems appropriate except for matters related to our activities in the People’s Republic of China, on which Mr. Kidron willconsult with HTIT before taking any action as proxy. (3)Includes 312,134 shares of common stock issuable upon the exercise of outstanding stock options and 89,636 shares of Common Stock underlyingvested Restricted Stock Units that are issuable upon request. Also includes 1,155,367 shares of common stock held by HTIT, as further described infootnote (2) above, and 206,350 shares of common stock held by Xiaopeng Li, as further discussed in footnote (7) below. 51  (4)Includes 286,467 shares of common stock issuable upon the exercise of outstanding stock options and 75,000 shares of Common Stock underlyingvested RSUs that are issuable upon request. (5)Includes 100,800 shares of common stock issuable upon the exercise of outstanding stock options and 3,000 shares of common stock issuable uponthe settlement of RSUs. (6)Includes 9,675 shares of common stock issuable upon the exercise of outstanding stock options and 9,691 shares of common stock owned byShikma, of which Mr. Friedman is the sole owner and chief executive officer. All investment decisions are made by Mr. Friedman, and thus the powerto vote or direct the votes of these shares of common stock, as well as the power to dispose or direct the disposition of such shares of common stockis held by Mr. Friedman through Shikma. (7)Includes 17,844 shares of common stock issuable upon the exercise of outstanding stock options. The voting of these shares is subject to a revocableproxy granted to Nadav Kidron. On November 21, 2016, following her purchase of such shares, Ms. Li appointed Nadav Kidron as proxy andattorney in fact of Ms. Li, with full power of substitution, to cast on behalf of Ms. Li all votes that Ms. Li is entitled to cast with respect to the sharespurchased at any and all meeting of the shareholders of the Company, to consent or dissent to any action taken without a meeting and to vote all theshares held by Ms. Li in any manner Mr. Kidron deems appropriate except for matters related to the Company’s activities in the Territory and whenobvious that specific votes violate Ms. Li’s rights and interests, on which Mr. Kidron and Ms. Li will consult with each other in advance of the vote,and subsequently Mr. Kidron will vote according to Ms. Li’s instructions. The proxy will also apply to shares of the Company purchased by Ms. Lithrough open market transactions. Ms. Li may revoke the proxy in writing at any time. (8)Includes 21,288 shares of common stock issuable upon the exercise of outstanding stock options. (9)Includes: (a) 294,162 shares of common stock held by Mr. Sank; (b) 78,125 shares of common stock held by Mr. Sank’s wife; (c) 63,685 shares ofcommon stock issuable to Mr. Sank upon the exercise of outstanding stock options; and (d) 138,889 shares of common stock owned by a companywholly owned by a trust of which Mr. Sank is a trustee. Mr. Sank disclaims beneficial ownership of the securities referenced in (b) and (d) above. (10)See footnote (1) above. Also Includes 11,288 shares of common stock issuable upon the exercise of outstanding stock options. (11)Includes 846,828 shares of common stock issuable upon the exercise of options beneficially owned by the referenced persons, 164,636 shares ofCommon Stock underlying vested RSUs that are issuable upon request and 3,000 shares of common stock issuable upon the settlement of RSUs. ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE. During fiscal 2017 and 2016, except for compensation arrangements described elsewhere herein, we did not participate in any transaction, and weare not currently participating in any proposed transaction, or series of transactions, in which the amount involved exceeded the lesser of $120,000 or onepercent of the average of our total assets at year end for the last two completed fiscal years, and in which, to our knowledge, any of our directors, officers, fivepercent beneficial security holders, or any member of the immediate family of the foregoing persons had, or will have, a direct or indirect material interest. Our policy is to enter into transactions with related persons on terms that, on the whole, are no less favorable than those available from unaffiliatedthird parties. Based on our experience in the business sectors in which we operate and the terms of our transactions with unaffiliated third parties, we believethat all of the transactions described below met this policy standard at the time they occurred. All related person transactions are approved by our Board. 52  On November 30, 2015, we, our Israeli subsidiary and HTIT entered into a Technology License Agreement, which was further amended, according towhich we granted HTIT an exclusive commercialization license in the Territory related to our oral insulin capsule, ORMD-0801. Pursuant to this licenseagreement, HTIT will conduct certain pre-commercialization and regulatory activities with respect to our technology related to the ORMD-0801 capsule, andwill pay certain royalties and an aggregate of approximately $37.5 million. On November 30, 2015, we also entered into a securities purchase agreement withHTIT, pursuant to which, among other things, Mr. Kidron will serve as proxy and attorney in fact of HTIT, with full power of substitution, to cast on behalf ofHTIT all votes that HTIT is entitled to cast with respect to the Purchased Shares at any and all meetings of our shareholders to consent or dissent to any actiontaken without a meeting and to vote all the Purchased Shares held by HTIT in any manner Mr. Kidron deems appropriate except for matters related to ouractivities in the People’s Republic of China, on which Mr. Kidron will consult with HTIT before taking any action as proxy. The Board has determined that Leonard Sank, David Slager, Kevin Rakin, Aviad Friedman and Xiaopeng Li are independent as defined under therules promulgated by Nasdaq. ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES. The aggregate fees billed by Kesselman & Kesselman, independent registered public accounting firm, and member firm of PricewaterhouseCoopersInternational Limited, for services rendered to us during fiscals 2017 and 2016: 2017 2016 Audit Fees(1) $109,000 $116,000 Audit-Related Fees - - Tax Fees(2) 4,000 32,000 All Other Fees - - Total Fees $113,000 $148,000 (1)Amount represents fees paid for professional services for the audit of our consolidated annual financial statements, review of our interim condensedconsolidated financial statements included in quarterly reports and services that are normally provided by our independent registered public accountingfirm in connection with statutory and regulatory filings or engagements. (2)Represents fees paid for tax consulting services. SEC rules require that before the independent registered public accounting firm are engaged by us to render any auditing or permitted non-auditrelated service, the engagement be: (1) pre-approved by our Audit Committee; or (2) entered into pursuant to pre-approval policies and proceduresestablished by the Audit Committee, provided the policies and procedures are detailed as to the particular service, the Audit Committee is informed of eachservice, and such policies and procedures do not include delegation of the Audit Committee’s responsibilities to management. The Audit Committee pre-approves all services provided by our independent registered public accounting firm. All of the above services and feeswere reviewed and approved by the Audit Committee before the services were rendered. 53  PART IV ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES. (a)Index to Financial Statements The following consolidated financial statements are filed as part of this Annual Report on Form 10-K: Page REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM F - 1CONSOLIDATED FINANCIAL STATEMENTS: Balance sheets F - 2Statements of comprehensive loss F - 3Statements of changes in stockholders’ equity F - 4Statements of cash flows F - 5Notes to financial statements F - 6 - F - 30 _________________________________________________________________________________________________ 54  REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRMTo the Shareholders ofORAMED PHARMACEUTICALS INC. We have audited the accompanying consolidated balance sheets of Oramed Pharmaceuticals Inc. and its subsidiary as of August 31, 2017 and 2016, and therelated consolidated statements of comprehensive loss, changes in stockholders’ equity and cash flows for each of the three years in the period ended August31, 2017. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financialstatements based on our audit. We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require thatwe plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includesexamining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accountingprinciples used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our auditprovides a reasonable basis for our opinion. In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of OramedPharmaceuticals Inc. and its subsidiary as of August 31, 2017 and 2016, and the results of its operations and its cash flows for each of the three years in theperiod ended August 31, 2017, in conformity with accounting principles generally accepted in the United States of America. Tel Aviv, Israel /s/ Kesselman & KesselmanNovember 29, 2017 Kesselman & Kesselman Certified Public Accountants (Isr.) A member firm of PricewaterhouseCoopers International Limited Kesselman & Kesselman, Trade Tower, 25 Hamered Street, Tel-Aviv 6812508, Israel,P.O Box 50005 Tel-Aviv 6150001 Telephone: +972 -3- 7954555, Fax:+972 -3- 7954556, www.pwc.com/il F-1  ORAMED PHARMACEUTICALS INC.CONSOLIDATED BALANCE SHEETSU.S. Dollars in thousands (except share and per share data) August 31, 2017 2016 ASSETS CURRENT ASSETS: Cash and cash equivalents $3,969 $3,907 Short-term deposits (note 2) 13,293 24,254 Marketable securities (note 3) 2,860 2,855 Restricted cash 16 16 Prepaid expenses and other current assets 159 198 Total current assets 20,297 31,230 LONG-TERM ASSETS: Long-term deposits and investment (note 4) 16,232 11,043 Marketable securities (note 3c) 2,151 530 Amounts funded in respect of employee rights upon retirement 14 11 Property and equipment, net 18 16 Total long-term assets 18,415 11,600 Total assets $38,712 $42,830 LIABILITIES AND STOCKHOLDERS' EQUITY CURRENT LIABILITIES: Accounts payable and accrued expenses $2,716 $1,411 Deferred revenues 2,449 2,162 Related parties (note 11c) - 48 Total current liabilities 5,165 3,621 LONG-TERM LIABILITIES: Deferred revenues 13,837 12,604 Employee rights upon retirement 18 14 Provision for uncertain tax position (note 10e) 11 11 Other liabilities 443 390 Total long-term liabilities 14,309 13,019 COMMITMENTS (note 6) STOCKHOLDERS’ EQUITY: Common stock, $ 0.012 par value (30,000,000 authorized shares as of August 31, 2017 and 2016; 13,668,530 and13,183,425 shares issued and outstanding as of August 31, 2017 and 2016, respectively) 163 157 Additional paid-in capital 75,170 71,943 Accumulated other comprehensive income 401 106 Accumulated loss (56,496) (46,016)Total stockholders’ equity 19,238 26,190 Total liabilities and stockholders’ equity $38,712 $42,830 The accompanying notes are an integral part of the financial statements. F-2  ORAMED PHARMACEUTICALS INC.CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSSU.S. Dollars in thousands (except share and per share data) Year ended August 31, 2017 2016 2015 REVENUES $2,456 $641 $- COST OF REVENUES (notes 6j, 6k) 187 490 - RESEARCH AND DEVELOPMENT EXPENSES, NET 10,281 7,709 4,781 GENERAL AND ADMINISTRATIVE EXPENSES 2,759 2,452 2,602 OPERATING LOSS 10,771 10,010 7,383 FINANCIAL INCOME (note 9a) 792 474 168 FINANCIAL EXPENSES (note 9b) 101 93 18 LOSS BEFORE TAXES ON INCOME 10,080 9,629 7,233 TAXES ON INCOME (TAX BENEFIT) (note 10c) 400 1,335 (1)NET LOSS FOR THE YEAR $10,480 $10,964 $7,232 UNREALIZED LOSS (GAIN) ON AVAILABLE FOR SALE SECURITIES (295) 452 (106)TOTAL OTHER COMPREHENSIVE LOSS (INCOME) (295) 452 (106)TOTAL COMPREHENSIVE LOSS FOR THE PERIOD $10,185 $11,416 $7,126 LOSS PER SHARE OF COMMON STOCK: BASIC AND DILUTED LOSS PER SHARE OF COMMON STOCK $0.79 $0.87 $0.67 WEIGHTED AVERAGE NUMBER OF SHARES OF COMMON STOCK USED INCOMPUTING BASIC AND DILUTED LOSS PER SHARE OF COMMON STOCK 13,309,372 12,624,356 10,820,465 The accompanying notes are an integral part of the financial statements. F-3  ORAMED PHARMACEUTICALS INC.CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITYU.S. Dollars in thousands (except share data) Additional Accumulatedother Total Common Stock paid-in comprehensive Accumulated stockholders’ Shares $ capital income loss equity In thousands BALANCE AS OF AUGUST 31, 2014 10,103 $121 $48,040 $452 $(27,820) $20,793 SHARES, OPTIONS AND WARRANTSISSUED FOR CASH, NET 1,411 17 9,696 - - 9,713 SHARES ISSUED FOR SERVICES 15 * 93 - - 93 EXERCISE OF OPTIONS 1 * 8 - - 8 STOCK-BASED COMPENSATION 33 * 1,347 - - 1,347 OTHER COMPREHENSIVE INCOME - - - 106 - 106 NET LOSS - - - - (7,232) (7,232)BALANCE AS OF AUGUST 31, 2015 11,563 138 59,184 558 (35,052) 24,828 ISSUANCE OF COMMON STOCK, NET 1,155 14 10,580 - - 10,594 SHARES ISSUED FOR SERVICES 14 * 101 - - 101 EXERCISE OF WARRANTS ANDOPTIONS 350 4 1,445 - - 1,449 STOCK-BASED COMPENSATION 101 1 633 - - 634 OTHER COMPREHENSIVE LOSS - - - (452) - (452)NET LOSS - - - - (10,964) (10,964)BALANCE AS OF AUGUST 31, 2016 13,183 157 71,943 106 (46,016) 26,190 SHARES ISSUED FOR SERVICES 10 * 72 - - 72 ISSUANCE OF COMMON STOCK, NET 3 * 25 - - 25 EXERCISE OF WARRANTS ANDOPTIONS 313 4 1,557 - - 1,561 STOCK-BASED COMPENSATION 159 2 1,573 - - 1,575 OTHER COMPREHENSIVE INCOME - - - 295 - 295 NET LOSS - - - - (10,480) (10,480)BALANCE AS OF AUGUST 31, 2017 13,668 $163 $75,170 $401 $(56,496) $19,238 * Represents an amount of less than $1. The accompanying notes are an integral part of the financial statements F-4  ORAMED PHARMACEUTICALS INC.CONSOLIDATED STATEMENTS OF CASH FLOWSU.S. Dollars in thousands Year ended August 31, 2017 2016 2015 CASH FLOWS FROM OPERATING ACTIVITIES: Net loss $(10,480) $(10,964) $(7,232)Adjustments required to reconcile net loss to net cash provided by (used in) operating activities: Depreciation 5 4 4 Exchange differences and interest on deposits and held to maturity bonds 124 (163) (20)Stock-based compensation 1,575 634 1,347 Shares issued for services 72 101 93 Changes in operating assets and liabilities: Prepaid expenses, other current assets and related parties 39 (71) 345 Accounts payable, accrued expenses and related parties 1,257 470 16 Deferred revenue 1,520 14,266 500 Liability for employee rights upon retirement 4 3 2 Provision for uncertain tax position - (15) (1)Other liabilities 53 390 - Total net cash provided by (used in) operating activities (5,831) 4,655 (4,946) CASH FLOWS FROM INVESTING ACTIVITIES: Purchase of property and equipment (7) (9) (1)Purchase of short-term deposits (3,557) (7,010) (3,673)Purchase of long-term deposits (17,230) (22,274) (17,452)Purchase of held to maturity securities (3,869) (1,775) (1,885)Proceeds from sale of short-term deposits 26,551 14,160 19,701 Proceeds from maturity of held to maturity securities 2,417 900 - Funds in respect of employee rights upon retirement (3) (2) (2)Total net cash provided by (used in) investing activities 4,302 (16,010) (3,312) CASH FLOWS FROM FINANCING ACTIVITIES: Proceeds from issuance of common stock, options and warrants - net of issuance costs 25 10,594 9,713 Proceeds from exercise of warrants and options 1,561 1,449 8 Total net cash provided by financing activities 1,586 12,043 9,721 EFFECT OF EXCHANGE RATE CHANGES ON CASH 5 6 (12)INCREASE IN CASH AND CASH EQUIVALENTS 62 694 1,451 CASH AND CASH EQUIVALENTS AT BEGINNING OF PERIOD 3,907 3,213 1,762 CASH AND CASH EQUIVALENTS AT END OF PERIOD $3,969 $3,907 $3,213 SUPPLEMENTARY DISCLOSURE ON CASH FLOWS - Interest received $833 $256 $115 The accompanying notes are an integral part of the financial statements F-5  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTSU.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES: a.General 1)Incorporation and operations Oramed Pharmaceuticals Inc. (collectively with its subsidiary, the “Company”, unless the context indicates otherwise) wasincorporated on April 12, 2002, under the laws of the State of Nevada. From incorporation until March 3, 2006, the Company wasan exploration stage company engaged in the acquisition and exploration of mineral properties. On February 17, 2006, theCompany entered into an agreement with Hadasit Medical Services and Development Ltd. (“Hadasit”) to acquire the provisionalpatent related to orally ingestible insulin capsule to be used for the treatment of individuals with diabetes. On May 14, 2007, the Company incorporated a wholly-owned subsidiary in Israel, Oramed Ltd. (the “Subsidiary”), which isengaged in research and development. On March 11, 2011, the Company was reincorporated from the State of Nevada to the State of Delaware. On November 30, 2015, the Company entered into a Technology License Agreement with Hefei Tianhui Incubation ofTechnologies Co. Ltd. (“HTIT”) and on December 21, 2015, the parties entered into an Amended and Restated TechnologyLicense Agreement, that was further amended by the parties on June 3, 2016 and July 24, 2016 (the “License Agreement”).According to the License Agreement, the Company granted HTIT an exclusive commercialization license in the territory of thePeople's Republic of China, Macau and Hong Kong (the “Territory”), related to the Company’s oral insulin capsule, ORMD-0801(the "Product"). Pursuant to the License Agreement, HTIT will conduct, at its own expense, certain pre-commercialization andregulatory activities with respect to the Subsidiary’s technology and ORMD-0801 capsule, and will pay to the Subsidiary (i)royalties of 10% on net sales of the related commercialized products to be sold by HTIT in the Territory (“Royalties”), and (ii) anaggregate of $37,500, of which $3,000 was payable immediately, $8,000 will be paid subject to the Company entering into certainagreements with certain third parties, and $26,500 will be paid upon achievement of certain milestones and conditions. In theevent that the Company does not meet certain conditions, the Royalties rate may be reduced to a minimum of 8%. Following thefinal expiration of the Company's patents covering the technology in the Territory in 2033, the Royalties rate may be reduced,under certain circumstances, to 5%. The royalty payment obligation shall apply during the period of time beginning upon the first commercial sale of the Product inthe Territory, and will end upon the later of (i) the expiration of the last-to-expire licensed patents in the Territory; and (ii) 15 yearsafter the first commercial sale of the Product in the Territory (the "Royalty Term"). The License Agreement shall remain in effect until the expiration of the Royalty Term. The License Agreement contains customarytermination provisions. Among others, the Company's involvement through the product submission date will include consultancy for the pre-commercialization activities in the Territory, as well as advisory services to HTIT on an ongoing basis. F-6  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTSU.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): The initial payment of $3,000 was received in January 2016. Following the achievement of certain milestones, the second andthird payments of $6,500 and $4,000, respectively, were received in July 2016 and the fourth milestone payment of $4,000 wasreceived in October 2016. In addition, on November 30, 2015, the Company entered into a Stock Purchase Agreement with HTIT (the “SPA”). According tothe SPA, the Company issued 1,155,367 shares of common stock to HTIT for $12,000. The transaction closed on December 28,2015. The License Agreement and the SPA were considered a single arrangement with multiple deliverables. The Company allocated thetotal consideration of $49,500 between the License Agreement and the SPA according to their fair value, as follows: $10,617 wasallocated to the issuance of common stock (less issuance expenses of $23), based on the quoted price of the Company's shares onthe closing date of the SPA on December 28, 2015, and $38,883 was allocated to the License Agreement. Given the Company'scontinuing involvement through the expected product submission (June 2023), amounts received relating to the LicenseAgreement are recognized over the period from which the Company is entitled to the respective payment, and the expectedproduct submission date using a time-based model approach over the periods that the fees are earned. In July 2015, according to the letter of intent signed between the parties or their affiliates, HTIT's affiliate paid the Subsidiary anon-refundable amount of $500 as a no-shop fee. The no-shop fee was deferred and the related revenue is recognized over theestimated term of the License Agreement.Amounts that were allocated to the License Agreement as of August 31, 2017 aggregated $19,383, all of which were receivedthrough the balance sheet date. Through August 31, 2017, the Company recognized revenue in the amount of $3,097, and deferredthe remaining amount of $16,286. The following table summarizes the activities for deferred revenues for the years ended August 31, 2017 and 2016: August 31, 2017 2016 Deferred revenue at the beginning of period $14,766 $- Amounts received 4,000 15,383 Amounts the Company was entitled to (24) 24 Revenue recognized (2,456) (641) Deferred revenue at the end of period 16,286 14,766 Less – current deferred revenue portion (2,449) (2,162) Non-current deferred revenue portion $13,837 $12,604 2)Development and liquidity risks The Company is engaged in research and development in the biotechnology field for innovative pharmaceutical solutions,including an orally ingestible insulin capsule to be used for the treatment of individuals with diabetes, and the use of orallyingestible capsules for delivery of other polypeptides, and has not generated significant revenues from its operations. Continuedoperation of the Company is contingent upon obtaining sufficient funding until it becomes profitable. Successful completion of the Company’s development programs and its transition to normal operations is dependent uponobtaining necessary regulatory approvals from the U.S. Food and Drug Administration prior to selling its products within theUnited States, obtaining foreign regulatory approvals to sell its products internationally, or entering into licensing agreementswith third parties. There can be no assurance that the Company will receive regulatory approval of any of its product candidates,and a substantial amount of time may pass before the Company achieves a level of revenues adequate to support its operations, ifat all. The Company also expects to incur substantial expenditures in connection with the regulatory approval process for each ofits product candidates during their respective developmental periods. Obtaining marketing approval will be directly dependent onthe Company’s ability to implement the necessary regulatory steps required to obtain marketing approval in the United States andin other countries. The Company cannot predict the outcome of these activities. F-7  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): b.Basis of presentation The consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United Statesof America (“U.S. GAAP”). c.Use of estimates in the preparation of financial statements The preparation of the consolidated financial statements in conformity with U.S. GAAP requires management to make estimates andassumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the financialstatements date and the reported expenses during the reporting periods. Actual results could differ from those estimates. As applicable to these consolidated financial statements, the most significant estimates and assumptions relate to stock-basedcompensation and to the expected product submission date for revenue recognition purposes. d.Functional currency The currency of the primary economic environment in which the operations of the Company and its Subsidiary are conducted is the U.S.dollar (“$” or “dollar”). Therefore, the functional currency of the Company and its Subsidiary is the dollar. Transactions and balances originally denominated in dollars are presented at their original amounts. Balances in foreign currencies aretranslated into dollars using historical and current exchange rates for non-monetary and monetary balances, respectively. For foreigntransactions and other items reflected in the statements of operations, the following exchange rates are used: (1) for transactions - exchangerates at transaction dates or average rates and (2) for other items (derived from non-monetary balance sheet items such as depreciation) -historical exchange rates. The resulting transaction gains or losses are carried to financial income or expenses, as appropriate. e.Principles of consolidation The consolidated financial statements include the accounts of the Company and its Subsidiary. All inter-company transactions andbalances have been eliminated in consolidation. f.Cash equivalents The Company considers all short-term, highly liquid investments, which include short-term deposits with original maturities of threemonths or less from the date of purchase that are not restricted as to withdrawal or use and are readily convertible to known amounts of cash,to be cash equivalents. F-8  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): g.Fair value measurement: The Company measures fair value and discloses fair value measurements for financial assets and liabilities. Fair value is based on the pricethat would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at themeasurement date. In order to increase consistency and comparability in fair value measurements, the guidance establishes a fair valuehierarchy that prioritizes observable and unobservable inputs used to measure fair value into three broad levels, which are described asfollows: Level 1:Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair valuehierarchy gives the highest priority to Level 1 inputs. Level 2:Observable prices that are based on inputs other than quoted prices included within Level 1 that are observable for the asset orliability, either directly or indirectly. Level 3:Unobservable inputs are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level3 inputs. As of August 31, 2017, the assets or liabilities measured at fair value are comprised of available for sale equity securities (level 1). In determining fair value, the Company utilizes valuation techniques that maximize the use of observable inputs and minimize the use ofunobservable inputs to the extent possible. As of August 31, 2017, the carrying amount of cash and cash equivalents, short-term deposits, other current assets, accounts payable andaccrued expenses approximate their fair values due to the short-term maturities of these instruments. As of August 31, 2017, the carrying amount of long-term deposits approximates their fair values due to the stated interest rates whichapproximate market rates. The fair value of held to maturity bonds as presented in note 3 was based on a level 1 measurement. The amounts funded in respect of employee rights are stated at cash surrender value which approximates its fair value. There were no Level 3 items for the years ended August 31, 2017, 2016 and 2015. F-9  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): h.Marketable securities 1) Available-for-sale securities Available-for-sale equity securities are reported at fair value, with unrealized gains and losses, net of related tax recorded as a separatecomponent of accumulated other comprehensive income (loss) in equity until realized. Unrealized losses that are considered to be other-than-temporary are charged to statement of operations as an impairment charge and are included in the consolidated statement of operationsunder impairment of available-for-sale securities. The Company considers available evidence in evaluating potential impairments of itsinvestments, including the duration and extent to which fair value is less than cost, and the Company’s ability and intent to hold theinvestment. Realized gains and losses on sales of the securities are included in the consolidated statement of operations as financial incomeor expenses. Cost of the securities sold and amount reclassified out of accumulated other comprehensive income into financial income aredetermined by specific identification.2) Held to maturity securities All debt securities are classified as held-to-maturity because the Company has the positive intent and ability to hold the securities tomaturity. Held-to-maturity securities are stated at amortized cost, adjusted for amortization of premiums and accretion of discounts tomaturity. On a continuous basis, management assesses whether there are any indicators that the value of the Company’s marketablesecurities may be impaired, which includes reviewing the underlying cause of any decline in value and the estimated recovery period, aswell as the severity and duration of the decline. In the Company’s evaluation, the Company considers its ability and intent to hold theseinvestments for a reasonable period of time sufficient for the Company to recover its cost basis. A marketable security is impaired if the fairvalue of the security is less than the carrying value of the security and such difference is deemed to be other-than temporary. To the extentimpairment has occurred, the loss shall be measured as the excess of the carrying amount of the security over the estimated fair value in thesecurity. i.Concentration of credit risks Financial instruments that subject the Company to credit risk consist primarily of cash and cash equivalents, short and long-term depositsand marketable securities which are deposited in major financial institutions. The Company is of the opinion that the credit risk in respectof these balances is remote. As of the date of issuing these financial statements, all amounts due from HTIT have been received, as described in note 1 above. F-10  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): j.Income taxes 1. Deferred taxes Deferred taxes are determined utilizing the asset and liability method based on the estimated future tax effects of differences between thefinancial accounting and tax bases of assets and liabilities under the applicable tax laws. Deferred tax balances are computed using the taxrates expected to be in effect when those differences reverse. A valuation allowance in respect of deferred tax assets is provided if, basedupon the weight of available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. TheCompany has provided a full valuation allowance with respect to its deferred tax assets. See note 10. Regarding the Subsidiary, the recognition is prohibited for deferred tax liabilities or assets that arise from differences between the financialreporting and tax bases of assets and liabilities that are measured from the local currency into dollars using historical exchange rates, andthat result from changes in exchange rates or indexing for tax purposes. Consequently, the abovementioned differences were not reflectedin the computation of deferred tax assets and liabilities. Taxes that would apply in the event of disposal of investments in the Subsidiary have not been taken into account in computing deferredtaxes, as it is the Company’s intention to hold this investment, not to realize it. 2. Uncertainty in income tax The Company follows a two-step approach to recognizing and measuring uncertain tax positions. The first step is to evaluate the taxposition for recognition by determining if the weight of available evidence indicates that it is more likely than not that the position will besustained on audit. The second step is to measure the tax benefit as the largest amount that is more than 50% likely of being realized uponultimate settlement. Such liabilities are classified as long-term, unless the liability is expected to be resolved within twelve months from thebalance sheet date. The Company’s policy is to include interest and penalties related to unrecognized tax benefits within income taxexpenses. k.Revenue recognition Revenue is recognized when delivery has occurred, evidence of an arrangement exists, title and risks and rewards for the products aretransferred to the customer and collection is reasonably assured. Given the Company's continuing involvement through the expected product submission (June 2023), revenue from the License Agreementis recognized over the periods from which the Company is entitled to the respective payments, and through the expected productsubmission date. l.Cost of revenues Cost of revenues consists of royalties related to the License Agreement with HTIT. The royalties are recognized when proceeds related tothe License Agreement are received. F-11  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): m.Research and development, net Research and development expenses include costs directly attributable to the conduct of research and development programs, including thecost of salaries, employee benefits, the cost of supplies, the cost of services provided by outside contractors, including services related tothe Company’s clinical trials, clinical trial expenses and the full cost of manufacturing drug for use in research and preclinicaldevelopment. All costs associated with research and development are expensed as incurred. Clinical trial costs are a significant component of research and development expenses and include costs associated with third-partycontractors. The Company outsources a substantial portion of its clinical trial activities, utilizing external entities such as ContractResearch Organizations, independent clinical investigators, and other third-party service providers to assist the Company with theexecution of its clinical studies. For each clinical trial that the Company conducts, clinical trial costs are expensed immediately. Grants received from the IIA and from the Bio-Jerusalem fund (“Bio-Jerusalem”) are recognized as grant income when the grants becomereceivable, provided there is reasonable assurance that the Company will comply with the conditions attached to the grant and there isreasonable assurance the grant will be received. The grants are deducted from the related research and development expenses as the costsare incurred and are presented in R&D expenses, net. See also notes 6(j) and 6(k). n.Stock-based compensation Equity awards granted to employees are accounted for using the grant date fair value method. The grant date fair value is determined asfollows: for stock options and restricted stock units (“RSUs”) with an exercise price using the Black Scholes pricing model, for stockoptions with market conditions using a Monte Carlo model and for RSUs with service conditions based on the grant date share price. Thefair value of share based payment awards is recognized as an expense over the requisite service period. The expected term is the length oftime until the expected dates of exercising the award and is estimated using the simplified method due to insufficient specific historicalinformation of employees' exercise behavior, unless the award includes a market condition, in which case the contractual term is used. Thevolatility is based on a historical volatility, by statistical analysis of the weekly share price for past periods. The Company elected torecognize compensation cost for awards granted to employees that have a graded vesting schedule using the accelerated method based onthe multiple-option award approach. For awards with only market conditions, compensation expense is not reversed if the marketconditions are not satisfied. When stock options are granted as consideration for services provided by consultants and other non-employees, the transaction isaccounted for based on the fair value of the consideration received or the fair value of the stock options issued, whichever is more reliablymeasurable. The fair value of the options granted to consultants and other non-employees is measured on a final basis at the end of therelated service period using the Black Scholes pricing model and is recognized over the related service period using the straight-linemethod. The Company elects to account for forfeitures as they occur. o.Loss per common share Basic and diluted net loss per common share are computed by dividing the net loss for the period by the weighted average number of sharesof common stock outstanding for each period. Outstanding stock options, warrants and RSUs have been excluded from the calculation ofthe diluted loss per share because all such securities are anti-dilutive for all periods presented. The total number of common stock options,warrants and RSUs excluded from the calculation of diluted net loss was 1,827,719, 2,676,573 and 2,249,164 for the years ended August31, 2017, 2016 and 2015, respectively. F-12  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): p.Newly issued and recently adopted Accounting Pronouncements 1)In May 2014, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update ("ASU") No. 2014-09(Topic 606) “Revenue from Contracts with Customers” that will supersede most current revenue recognition guidance, includingindustry-specific guidance. The underlying principle of this ASU is that an entity will recognize revenue upon the transfer ofgoods or services to customers in an amount that the entity expects to be entitled to in exchange for those goods or services. Theguidance provides a five-step analysis of transactions to determine when and how revenue is recognized. Other major provisionsinclude capitalization of certain contract costs, consideration of the time value of money in the transaction price, and allowingestimates of variable consideration to be recognized before contingencies are resolved in certain circumstances. The guidance alsorequires enhanced disclosures regarding the nature, amount, timing and uncertainty of revenue and cash flows arising from anentity’s contracts with customers. The guidance is effective in annual reporting periods beginning after December 15, 2017,including interim reporting periods within that reporting period. The Company will implement the guidance for annual periodending on August 31, 2019 (early adoption is permitted for the interim and annual periods beginning on or after December 15,2016). The Company is currently evaluating the impact of the guidance on its consolidated financial statements. 2)In January 2016, the FASB issued guidance on recognition and measurement of financial assets and financial liabilities (ASU No.2016-01) that will supersede most current guidance. Changes to the U.S. GAAP model primarily affect the accounting for equityinvestments, financial liabilities under the fair value option and the presentation and disclosure requirements for financialinstruments. In addition, the FASB clarified guidance related to the valuation allowance assessment when recognizing deferred taxassets resulting from unrealized losses on available-for-sale debt securities. The accounting for other financial instruments, such asloans, investments in debt securities, and financial liabilities, is largely unchanged. The guidance is effective in annual reportingperiods beginning after December 15, 2017, including interim reporting periods within that reporting period. The Company willimplement the guidance for annual period ending on August 31, 2019 (early adoption is permitted for the interim and annualperiods beginning on or after December 15, 2016). The Company is currently evaluating the impact of the guidance on itsconsolidated financial statements. 3)In February 2016, the FASB issued ASU 2016-02, "Leases (Topic 842)" (“ASU 2016-02”), which supersedes the existing guidancefor lease accounting, "Leases (Topic 840)". ASU 2016-02 requires lessees to recognize leases on their balance sheets, and leaveslessor accounting largely unchanged. The amendments in ASU 2016-02 are effective for fiscal years beginning after December 15,2018 and interim periods within those fiscal years. Early application is permitted for all entities. ASU 2016-02 requires a modifiedretrospective approach for all leases existing at, or entered into after, the date of initial application, with an option to elect to usecertain transition relief. The Company is currently evaluating the impact of this new standard on its consolidated financialstatements. F-13  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES (continued): 4)In June 2016, the FASB issued ASU 2016-13, “Financial Instruments-Credit Losses (Topic 326)” ("ASU 2016-13"). ASU 2016-13requires that financial assets measured at amortized cost be presented at the net amount expected to be collected. The allowancefor credit losses is a valuation account that is deducted from the amortized cost basis. The income statement reflects themeasurement of credit losses for newly recognized financial assets, as well as the expected credit losses during the period. Themeasurement of expected credit losses is based upon historical experience, current conditions, and reasonable and supportableforecasts that affect the collectability of the reported amount. Credit losses relating to available-for-sale debt securities will berecorded through an allowance for credit losses rather than as a direct write-down to the security. ASU 2016-13 is effective forfiscal years beginning after December 15, 2019, including interim periods within those fiscal years. Early adoption is permitted asof the fiscal years beginning after December 15, 2018, including interim periods within those fiscal years. The Company iscurrently evaluating the impact of the guidance on its consolidated financial statements. 5)In August 2016, the FASB issued ASU 2016-15, “Statement of Cash Flow - Classification of Certain Cash Receipts and CashPayments (Topic 230)” ("ASU 2016-15"), which addresses a few specific cash flow issues with the objective of reducing theexisting diversity in practice in how certain cash receipts and cash payments are presented and classified in the statement of cashflows. ASU 2016-15 is effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscalyears. Early adoption is permitted, including adoption in an interim period. The Company is currently evaluating the impact ofthis new pronouncement on its consolidated financial statements. 6)In May 2017, the FASB issued ASU 2017-09, “Compensation - Stock Compensation (Topic 718) - Scope of ModificationAccounting” ("ASU 2017-09"), which gives direction on which changes to the terms or conditions of share-based payment awardsrequire an entity to apply modification accounting in ASC Topic 718. In general, entities will apply the modification accountingguidance if the value, vesting conditions or classification of the award changes. ASU 2017-09 is effective for fiscal yearsbeginning after December 15, 2017, including interim periods within those fiscal years. Early adoption is permitted, includingadoption in an interim period. The Company does not expect the implementation of this new pronouncement to have a materialimpact on its consolidated financial statements. F-14  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 2 - SHORT-TERM DEPOSITS: Composition: August 31, 2017 2016 Annualinterestrate Amount Annualinterest rate Amount Dollar deposits 1.84-5.95% $13,293 0.85-2% $24,254 NOTE 3 - MARKETABLE SECURITIES: a.Composition: The Company's marketable securities include investments in equity securities of D.N.A Biomedical Solutions Ltd (“D.N.A”) and in held tomaturity bonds. Composition: August 31, 2017 2016 Short-term: D.N.A (see b below) $996 $701 Held to maturity bonds (see c below) 1,864 2,154 $2,860 $2,855 Long-term: Held to maturity bonds (see c below) $2,151 $530 b.D.N.A The D.N.A ordinary shares are traded on the Tel Aviv Stock Exchange. The fair value of those securities is measured at the quoted prices ofthe securities on the measurement date. During the years ended August 31, 2017, 2016 and 2015, the Company did not sell any of the D.N.A ordinary shares. As of August 31,2017, the Company owns approximately 7.9% of D.N.A’s outstanding ordinary shares. The cost of the securities as of August 31, 2017 and 2016 and 2015 is $595. F-15  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 3 - MARKETABLE SECURITIES (continued): c.Held to maturity bonds The amortized cost and estimated fair value of held-to-maturity securities at August 31, 2017, are as follows: August 31, 2017 Amortizedcost Grossunrealizedlosses Estimatedfair value Short-term: Commercial bonds $1,823 $(1) $1,822 Accrued interest 41 - 41 Long-term 2,151 - 2,151 $4,015 $(1) $4,014 As of August 31, 2017, the contractual maturities of debt securities classified as held-to-maturity are as follows: after one year through twoyears, $2,151 and the yield to maturity rates vary between 1.30% to 1.87%. The amortized cost and estimated fair value of held-to-maturity securities at August 31, 2016, are as follows: August 31, 2016 Amortizedcost Grossunrealizedgains Estimatedfair value Short-term: Commercial bonds $2,118 $- $2,118 Accrued interest 36 - 36 Long-term 530 1 531 $2,684 $1 $2,685 As of August 31, 2016, the contractual maturities of debt securities classified as held-to-maturity are as follows: after one year through twoyears, $530, and the yield to maturity rates vary between 0.96% to 1.8%. NOTE 4 - LONG-TERM DEPOSITS: Composition: August 31, 2017 2016 Bank deposits (see (1) below) $16,230 $11,038 Lease car deposits 1 4 Investment 1 1 $16,232 $11,043 (1)Represents U.S. dollar bank deposits which carry fixed annual interest rates between 2.06% to 2.56%, with maturities of more than oneyear from balance sheet date. The latest maturity date is during the year ending August 31, 2019. F-16  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 5 - ACCOUNTS PAYABLE AND ACCRUED EXPENSES: Composition: August 31, 2017 2016 Accounts payable $571 $365 Payroll and related accruals 97 66 Institutions 228 - Accrued liabilities 1,593 980 Other 227 - $2,716 $1,411 NOTE 6 - COMMITMENTS: a.In March 2011, the Subsidiary sold shares of its investee company, Entera Bio Ltd. (“Entera”) to D.N.A, retaining a 3% interest as of March2011, which is accounted for as a cost method investment (amounting to $1). In consideration for the shares sold to D.N.A, the Companyreceived, among other payments, 4,202,334 ordinary shares of D.N.A (see also note 3). As part of this agreement, the Subsidiary entered into a patent transfer agreement, according to which the Subsidiary assigned to Entera allof its right, title and interest in and to the patent application that it has licensed to Entera since August 2010. Under this agreement, theSubsidiary is entitled to receive from Entera royalties of 3% of Entera’s net revenues (as defined in the agreement) and a license back of thatpatent application for use in respect of diabetes and influenza. As of August 31, 2017, Entera had not yet realized any revenues and had notpaid any royalties to the Subsidiary. In addition, as part of a consulting agreement with a third party, dated February 15, 2011, the Subsidiary is obliged to pay this third partyroyalties of 8% of the net royalties received in respect of the patent that was sold to Entera in March 2011. b.On January 3, 2017, the Subsidiary entered into a lease agreement for its office facilities in Israel. The lease agreement is for a period of 60months commencing October 1, 2016. The annual lease payment will be New Israeli Shekel (“NIS”) 119,000 ($33) from October 2016 through September 2018 and NIS 132,000($37) from October 2018 through September 2021, and will be linked to the increase in the Israeli consumer price index (“CPI”) (as ofAugust 31, 2017, the future lease payments until the expiration of the lease agreement will be $143, based on the exchange rate as ofAugust 31, 2017). As security for its obligation under this lease agreement, the Company provided a bank guarantee in an amount equal to three monthlylease payments. The lease expenses for the years ended August 31, 2017, 2016 and 2015 were $32, $23 and $23, respectively. c.On March 3, 2016, the Subsidiary entered into an agreement with a vendor for process development and production of its capsules and onNovember 24, 2016, April 3, 2017 and July 10, 2017 into amendments to such agreement in an amount of up to Swiss Franc (“CHF”)1,000,000 ($1,027), CHF 605,000 ($615) of which was recognized through August 31, 2017. F-17  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 6 - COMMITMENTS (continued): d.On May 11, 2016, the Subsidiary entered into a Master Service Agreement with a vendor to retain its services for a pre-clinical toxicologytrial for an oral GLP-1 analog capsule for type 2 diabetes patients. As consideration for its services, the Subsidiary will pay the vendor atotal amount of $1,283 during the term of the engagement and based on achievement of certain milestones, of which $1,163 was recognizedthrough August 31, 2017. e.On June 13, 2016, the Subsidiary entered into a four-year service agreement with a third party and on December 19, 2016, this agreementand all of the third party rights and obligations thereunder were assigned to another third party. This agreement is required by the LicenseAgreement as described in note 1 and will support the Company's research and development. The Subsidiary is obligated to pay the thirdparty a total amount of up to €2,360,000 ($2,726), of which €800,000 ($878) is a non-refundable fee to be paid within 12 months from theeffective date, all of which was recognized in research and development through August 31, 2017. The remaining fee will be paid over theterm of the engagement and will be based on achievement of certain milestones. f.On March 3, 2014, the Subsidiary entered into a Master Service Agreement with a vendor for the process development and production ofone of its oral capsule ingredients in the amount of $311, $175 of which was recognized through August 31, 2017, and bonus payments ofup to $600 that will be paid upon achieving certain milestones, as described in the agreement, none of which was recognized throughAugust 31, 2017. On July 24, 2016, the Subsidiary entered into a General Technical Agreement with the same vendor, for the scale-up process developmentand production of the same capsule ingredients in the amount of $4,300 that will be paid over the term of the engagement and based on theachievement of certain development milestones, $3,327 of which were recognized in research and development through August 31, 2017.This agreement is part of the requirements of the License Agreement as described in note 1. g.On February 21, 2017, the Subsidiary entered into an agreement with a vendor to retain its services for a pre-clinical toxicology trial for anoral insulin capsule for type 2 and type 1 diabetes patients. As consideration for its services, the Subsidiary will pay the vendor a total of upto $952 during the term of the engagement and based on achievement of certain milestones, of which $594 was recognized through August31, 2017. h.On May 3, 2017, the Company entered into a consulting agreement with a third party advisor for a period of one year, pursuant to whichsuch advisor will provide investor relations services and will be entitled to receive a monthly cash fee and 10,000 shares of the Company’scommon stock that will be issued in four equal quarterly installments commencing August 1, 2017. As of August 31, 2017, the Companyhad issued to such advisor 2,500 shares. The fair value of the shares at the grant date was $20. i.On June 5, 2017, the Subsidiary entered into a clinical research agreement with a vendor, for the conduct of its clamp clinical trial for anoral insulin capsule for type 1 diabetes patients. As consideration for its services, the Subsidiary will pay the vendor a total amount of $958during the term of the engagement and based on achievement of certain milestones, $160 of which was recognized through August 31,2017. j.Grants from the Bio-Jerusalem Fund (“Bio-Jerusalem”) The Subsidiary is committed to pay royalties to Bio-Jerusalem on proceeds from future sales at a rate of 4% and up to 100% of the amountof the grant received (Israeli CPI linked) at the total amount of $65. The Company received no grants from Bio-Jerusalem since fiscal year2013. F-18  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 6 - COMMITMENTS (continued): Royalty expenses for the year ended August 31, 2017 of $47 are included in cost of revenues. As of August 31, 2017, the Subsidiary hadrealized revenues from its related project in the amount of $2,653. k.Grants from the IIA Under the terms of the Company’s funding from the IIA, royalties of 3.5% are payable on sales of products developed from a project sofunded, up to a maximum amount equaling 100%-150% of the grants received (dollar linked) with the addition of interest at an annual ratebased on LIBOR. At the time the grants were received, successful development of the related projects was not assured. The total amount that was received through August 31, 2017 was $2,194. Royalty expenses for the year ended August 31, 2017 of $140 are included in cost of revenues and will be paid over the term of the LicenseAgreement in accordance with the revenue recognized from the related project. As of August 31, 2017, the Subsidiary had realized revenuesfrom its project in the amount of $2,653. l.For the years ended August 31, 2017 and 2016, no grants from the IIA were recognized. For the year ended August 31, 2015, the researchand development expenses are presented net of IIA grants in the total amount of $49. NOTE 7 - STOCKHOLDERS’ EQUITY: The following are the significant capital stock transactions that took place during the years ended August 31, 2017, 2016 and 2015: a.On November 3, 2014, the Company entered into a Stock Purchase Agreement with Guangxi Wuzhou Pharmaceutical (Group) Co., Ltd.,pursuant to which the Company issued to such investor an aggregate of 696,378 shares of common stock, at a price of $7.18 per share,which was equal to the closing price of the Company’s common stock on the Nasdaq Capital Market on October 31, 2014, for aggregategross proceeds of approximately $5,000. The net proceeds to the Company from the offering were approximately $4,833, after deducting afinder's fee of $150 and other offering expenses of the Company. The offering closed on November 28, 2014. b.On April 2, 2015, the Company entered into an At The Market Issuance Sales Agreement and on April 5, 2017 into an amendment to suchagreement (as amended, the “Sales Agreement”) with FBR Capital Markets & Co. (“FBR”) pursuant to which the Company may, from timeto time and at its option, issue and sell shares of its common stock having an aggregate offering price of up to $25,000 through FBR as itssales agent, subject to certain terms and conditions. Any shares sold will be sold pursuant to the Company’s effective shelf registrationstatement on Form S-3 including a prospectus dated February 2, 2017, as supplemented by a prospectus supplement dated April 5, 2017.The Company will pay FBR a commission of 3.0% of the gross proceeds of the sale of any shares sold through FBR. As of August 31, 2017,2,970 shares were sold under the Sales Agreement and an additional 453,919 shares were subsequently sold during September and October2017. F-19  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 7 - STOCKHOLDERS’ EQUITY (continued): c.On June 4, 2015, the Company entered into a letter of agreement (the “Engagement Letter”) with H.C. Wainwright & Co., LLC (“HCW”),pursuant to which HCW agreed to serve as exclusive agent, advisor or underwriter in any offering of the Company occurring between June4, 2015 and July 4, 2015. On June 5, 2015, the Company entered into a Securities Purchase Agreement, pursuant to which the Companyagreed to sell, in a registered direct offering (the “June 2015 Offering”): (1) an aggregate of 714,286 shares (the “Shares”) of the Company’scommon stock at a price of $7.50 per Share to six investors (the “Purchasers”) and (2) at the option of each Purchaser (the “OverallotmentRight”), additional shares of the Company’s common stock (the “Overallotment Shares”) up to the number equal to the number of theShares purchased by such Purchaser and at a price of $10.00 per Overallotment Share. The closing of the sale of the Shares occurred on June10, 2015. The Overallotment Right shall be exercisable beginning December 10, 2015, and shall remain exercisable until December 10,2016. Pursuant to the Engagement Letter, HCW received, for its services in the June 2015 Offering, a fee equal to 7% of the gross proceedsraised in the June 2015 Offering and an expense allowance of 1% of the gross proceeds raised in the June 2015 Offering, and affiliates ofHCW received warrants to purchase 28,571 shares of common stock of the Company, exercisable immediately and expires after a period ofthree years and with an exercise price of $10.00 per share. The net proceeds to the Company from the June 2015 Offering wereapproximately $4,880, after deducting HCW’s expenses and other offering expenses of the Company totaling $478. d.On December 28, 2015, the Company completed a private placement of 1,155,367 shares of the Company's common stock to HTIT. Seealso note 1. e.As of August 31, 2017, the Company had outstanding warrants exercisable for 166,642 shares of common stock at exercise prices rangingfrom $3.7656 to $10.00 per share and expiring at various dates between November 2, 2017 and June 10, 2018. The following table presents the warrant activity for the years ended August 31, 2017, 2016 and 2015: 2017 2016 2015 Warrants Weighted-AverageExercisePrice Warrants Weighted-AverageExercisePrice Warrants Weighted-AverageExercisePrice Warrants outstanding as of September 1 615,338 $5.92 981,940 $5.29 953,369 $5.15 Issued - $- - $- 28,571 $10.00 Exercised (248,882) $4.99 (331,054) $4.04 - $- Expired (199,814) $6.82 (35,548) $6.00 - $- Warrants outstanding as of August 31 166,642 $6.46 615,338 $5.92 981,940 $5.29 Warrants exercisable as of August 31 166,642 $6.46 615,338 $5.92 981,496 $5.29 F-20  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION: As of August 31, 2017, the Company has one stock option plan, the Second Amended and Restated 2008 Stock Incentive Plan, under which, theCompany had reserved a pool of 2,400,000 shares of the Company’s common stock which may be issued at the discretion of the Company’sBoard of Directors from time to time. Under this Plan, each option is exercisable into one share of common stock of the Company. The optionsmay be exercised after vesting and in accordance with vesting schedules which will be determined by the Board of Directors for each grant. Themaximum term of the options is 10 years. The following are the significant stock options transactions with employees, board members and non-employees made during the years endedAugust 31, 2017, 2016 and 2015: a.On November 13, 2014, the Company granted a total of 19,576 RSUs representing a right to receive shares of the Company’s commonstock to the Company’s Chief Executive Officer (the "CEO"), and the Company’s Chief Scientific Officer (the "CSO"), both related parties.The RSUs vested in two equal installments, each of 9,788 shares, on November 30, 2014 and December 31, 2014. The total fair value ofthese RSUs on the date of grant was $135, using the quoted closing market share price of $6.90 on the Nasdaq on the date of grant. Theshares of common stock underlying the RSUs will be issued upon request of the grantee. As of August 31, 2017, 9,788 RSUs were vestedand outstanding and the remaining 9,788 were exercised. b.On November 13, 2014, the Company granted a total of 10,872 RSUs representing a right to receive shares of the Company’s commonstock to four members of the Company's Board of Directors. The RSUs vested on January 1, 2015. The total fair value of these RSUs on thedate of grant was $75, using the quoted closing market share price of $6.90 on the Nasdaq Capital Market on the date of grant. c.On February 23, 2015, the Company granted a total of 159,696 RSUs representing a right to receive shares of the Company’s common stockto the Company’s CEO and the CSO, both related parties. The RSUs vest in 23 installments consisting of one installment of 13,308 shareson February 28, 2015 and 22 equal monthly installments of 6,654 shares each, commencing March 31, 2015. The total fair value of theseRSUs on the date of grant was $728, using the quoted closing market share price of $4.56 on the Nasdaq Capital Market on the date ofgrant. The shares of common stock underlying the RSUs will be issued upon request of the grantee. As of August 31, 2017, 79,848 RSUswere vested and outstanding and the remaining 79,848 were exercised. d.On February 23, 2015, the Company granted a total of 88,712 RSUs representing a right to receive shares of the Company’s common stockto four members of the Company's Board of Directors (22,178 RSUs to each director). The RSUs vested in two equal installments of 44,356shares on each of December 31, 2015 and December 31, 2016. The total fair value of these RSUs on the date of grant was $405, using thequoted closing market share price of $4.56 on the Nasdaq Capital Market on the date of grant. On August 24, 2016 the Company determined, with respect to three of these members of the Company's Board of Directors, to accelerate thesecond installment of their RSUs, such that 22,179 RSUs were vested on August 29, 2016 and their remaining 11,088 RSUs were forfeited. F-21  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION (continued): e.On February 23, 2015, the Company granted a total of 63,216 RSUs to three employees of the Subsidiary. The RSUs vest in 23 installments,consisting of one installment of 5,268 shares on February 28, 2015 and 22 equal monthly installments of 2,634 shares each, commencingMarch 31, 2015. The total fair value of these RSUs on the date of grant was $288, using the quoted closing market share price of $4.56 onthe Nasdaq Capital Market on the date of grant. f.On November 19, 2015, options to purchase an aggregate of 22,000 of the Company’s shares of common stock were granted to twoconsultants at an exercise price of $7.36 per share (equivalent to the traded market price on the date of grant) and expiration date ofNovember 19, 2025. 10,000 of the options vested in one installment on December 1, 2015, and the remaining 12,000 options vest in twelveequal quarterly installments, commencing January 1, 2016. On August 3, 2016 the consulting agreement with one of these consultants, to whom 12,000 options were granted, was terminated. As aresult, only 3,000 options were vested, and the remaining 9,000 unvested options were forfeited. In addition, the expiration date of the3,000 vested options was updated to November 3, 2016 (3 months following the termination date of the agreement). g.On November 1, 2016, the Company granted a total of 70,000 RSUs representing a right to receive 70,000 shares of the Company’s commonstock to an employee of the Subsidiary. The RSUs vest in 19 installments, consisting of one installment of 9,000 shares on November 1,2016, 18 equal monthly installments of 1,500 shares each, commencing November 30, 2016 and 17,000 shares on each of April 30, 2017and 2018. The total fair value of these RSUs on the date of grant was $463, using the quoted closing market share price of $6.62 on theNasdaq Capital Market on the date of grant. h.On February 9, 2017, options to purchase an aggregate of 27,731 shares of the Company were granted to four members of the Company’sBoard of Directors as follows: (a) 16,337 options at an exercise price of $1 per share (lower than the traded market price of $6.23 on the dateof grant). The fair value of these options on the date of grant was $90, using the Black Scholes option-pricing model and was based on thefollowing assumptions: Stock price of $6.23; dividend yield of 0% for all years; expected volatility of 77.29%; risk-free interest rates of1.88%; and expected term of 5 years; (b) 11,394 options at an exercise price of $6.23 per share (equivalent to the traded market price on thedate of grant). The fair value of these options on the date of grant was $45, using the Black Scholes option-pricing model and was based onthe following assumptions: Stock price of $6.23; dividend yield of 0% for all years; expected volatility of 77.29%; risk-free interest rates of1.88%; and expected term of 5 years. All the options vested immediately and expire on February 9, 2027. i.On March 20, 2017, options to purchase an aggregate of 37,152 of the Company’s shares of common stock were granted to a consultant at anexercise price of $6.00 per share (higher than the traded market price of $5.96 on the date of grant). The options expire on March 20, 2027.The options vest in 24 consecutive equal installments of 1,548 shares of common stock each, commencing March 31, 2017. The fair value ofthese options on the date of grant was $177. The fair value of these options as of August 31, 2017 was $261, using the Black Scholes option-pricing model and was based on the following assumptions: dividend yield of 0% for all years; expected volatility of 73.62%; risk-freeinterest rates of 2.12%; and expected term of 9.6 years. F-22  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION (continued): j.On June 30, 2017, the Company granted options to purchase shares of the Company and RSUs as follows: (1)To the CEO, options to purchase an aggregate of 147,000 shares of the Company, at an exercise price of $7.77 per share (equivalent tothe traded market price on the date of grant). The options shall vest in three equal annual installments of 49,000, on each of December31, 2017, 2018 and 2019, subject to the Company share price reaching the target of $8.00 per share, $9.50 per share and $12.50 pershare, respectively. These options expire on June 30, 2027. The fair value of the options at the date of grant was $585 using the MonteCarlo model, which utilizes multiple input variables to estimate the probability that market conditions will be achieved, and was basedon the following assumptions: dividend yield of 0% for all years; expected volatility of 75.00%; risk-free interest rates of 2.34%; andexpected term of 10 years. (2)To the CSO: (a) 75,000 RSUs representing a right to receive shares of the Company’s common stock which vested immediately, have anexercise price of $0.012 per share of common stock and expire on June 30, 2027. The total fair value of these RSUs on the date of grantwas $582, using the quoted closing market share price of $7.77 on the Nasdaq Capital Market on the date of grant; The shares ofcommon stock underlying the RSUs will be issued upon request of the grantee. As of August 31, 2017, none of these RSUs wereexercised. (b) options to purchase an aggregate of 69,999 shares of the Company, at an exercise price of $7.77 per share (equivalent tothe traded market price on the date of grant). The options shall vest in three equal annual installments of 23,333, on each of December31, 2017, 2018 and 2019. These options expire on June 30, 2027. The fair value of all these options on the date of grant was $359,using the Black Scholes option-pricing model and was based on the following assumptions: stock price of $7.77; dividend yield of 0%for all years; expected volatility of 74.77%; risk-free interest rates of 1.89%; and expected term of 6 years. (3)To four members of the Company’s Board of Directors, options to purchase an aggregate of 67,092 shares of the Company (16,773options to each director), at an exercise price of $7.77 per share (equivalent to the traded market price on the date of grant). The optionsshall vest in three equal annual installments, on each of December 31, 2017, 2018 and 2019. These options expire on June 30, 2027.The fair value of all these options on the date of grant was $344, using the Black Scholes option-pricing model and was based on thefollowing assumptions: stock price of $7.77; dividend yield of 0% for all years; expected volatility of 74.77%; risk-free interest rates of1.89%; and expected term of 6 years. (4)To a member of the Company’s Board of Directors, options to purchase an aggregate of 56,773 shares of the Company at an exerciseprice of $7.77 per share (equivalent to the traded market price on the date of grant). The options shall vest in four annual installments,15,591 of which shall vest on each of December 31, 2017, 2018 and 2019, and 10,000 of which shall vest on December 31, 2020. Theseoptions expire on June 30, 2027. The fair value of all these options on the date of grant was $294, using the Black Scholes option-pricing model and was based on the following assumptions: stock price of $7.77; dividend yield of 0% for all years; expected volatilityof 74.15%; risk-free interest rates of 2.14%; and expected term of 6.18 years. (5)To employees of the Subsidiary, options to purchase an aggregate of 38,901 shares of the Company, at an exercise price of $7.77 pershare (equivalent to the traded market price on the date of grant). The options shall vest in three equal annual installments, on each ofDecember 31, 2017, 2018 and 2019. These options expire on June 30, 2027. The fair value of all these options on the date of grant was$200, using the Black Scholes option-pricing model and was based on the following assumptions: stock price of $7.77; dividend yieldof 0% for all years; expected volatility of 74.77%; risk-free interest rates of 1.89%; and expected term of 6 years. F-23  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION (continued): k.On July 19, 2017, options to purchase an aggregate of 20,001 shares of the Company were granted to an employee of the Subsidiary. Thefair value of all these options on the date of grant was $113, using the Black Scholes option-pricing model and was based on the followingassumptions: Stock price of $8.57; dividend yield of 0% for all years; expected volatility of 74.65%; risk-free interest rates of 1.83%; andexpected term of 6 years. l.Options to employees, directors and non-employees The fair value of each option grant is estimated on the date of grant using the Black Scholes option-pricing model or Monte Carlo modelwith the following assumptions: For options granted in the year endedAugust 31, 2017 2016 Expected option life (years) 5.00-10.00 10.00 Expected stock price volatility (%) 74.15-77.29 80.46 Risk free interest rate (%) 1.83-2.47 2.24 Expected dividend yield (%) 0.0 0.0 No options were granted in fiscal year 2015. A summary of the status of the stock options granted to employees and directors as of August 31, 2017, 2016 and 2015, and changes duringthe years ended on those dates, is presented below: Year ended August 31, 2017 2016 2015 Numberofoptions Weightedaverageexerciseprice Numberofoptions Weightedaverageexerciseprice Numberofoptions Weightedaverageexerciseprice $ $ $ Options outstanding at beginning of year 904,234 6.75 904,234 6.75 908,901 6.75 Changes during the year: Granted 427,497 7.51 - - - - Forfeited - - - - (3,297) 6.00 Expired (59,282) 10.27 Exercised 63,900 5 - - (1,370) 6.00 Options outstanding at end of year 1,208,549 6.94 904,234 6.75 904,234 6.75 Options exercisable at end of year 808,783 904,234 883,234 Weighted average fair value of optionsgranted during the year $4.75 $- $- F-24  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION (continued): Costs incurred in respect of stock options granted to employees and directors, for the years ended August 31, 2017, 2016 and 2015 were$451, $14 and $278, respectively. The total intrinsic value of employees' options exercised during the year ended August 31, 2017 was $85. None of the options wereexercised by employees during the year ended August 31, 2016. The options exercised during the year ended August 31, 2015, were at aprice equal to the market price at the exercise date. The following table presents summary information concerning the options granted to employees and directors outstanding as of August 31,2017: Range ofexerciseprices Numberoutstanding WeightedAverageRemainingContractualLife Weightedaverageexerciseprice Aggregateintrinsic value $ Years $ $ 1.00 to 6.00 442,671 3.92 4.74 1,730,803 6.48 to 7.88 635,959 7.09 7.47 751,863 8.57 to 12.45 129,919 7.12 11.85 1,600 1,208,549 5.93 6.94 2,484,266 808,783 of options granted to employees and directors that were outstanding as of August 31, 2017, were also exercisable as of August 31,2017. As of August 31, 2017, there were $1,579 of unrecognized compensation costs related to non-vested options previously granted toemployees and directors. The unrecognized compensation costs are expected to be recognized over a weighted average period of 2.5 years. F-25  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION (continued): A summary of the status of the stock options granted to non-employees outstanding as of August 31, 2017, 2016 and 2015, and changesduring the years ended on this date, is presented below: Year ended August 31, 2017 2016 2015 Numberofoptions Weightedaverageexerciseprice Numberofoptions Weightedaverageexerciseprice Numberofoptions Weightedaverageexerciseprice $ $ $ Options outstanding at beginning of year 29,668 8.35 40,286 7.29 62,221 7.13 Changes during the year: Granted 37,152 6.00 22,000 7.36 Exercised - - (18,718) 6.00 - - Forfeited - - (9,000) 7.36 Expired (11,334) 8.65 (4,900) 6.00 (21,935) 6.82 Options outstanding at end of year 55,486 6.71 29,668 8.35 40,286 7.29 Options exercisable at end of year 27,622 29,668 36,119 The Company recorded stock-based compensation of $59, $102 and $3 during the years ended August 31, 2017, 2016 and 2015,respectively, related to non-employees' awards. The total intrinsic value of non-employees' options exercised during the year ended August 31, 2016, was $37. None of the options wereexercised by non-employees during the years ended August 31, 2017 and 2015. The following table presents summary information concerning the options granted to non-employees outstanding as of August 31, 2017: Range ofexerciseprices Numberoutstanding WeightedAverageRemainingContractualLife WeightedAverageExercisePrice Aggregateintrinsic value $ Years $ $ 6.00 37,152 9.56 6.00 98,453 7.36 10,000 8.22 7.36 12,900 9.12 8,334 1.36 9.12 - 55,486 8.09 6.71 111,353 27,622 options granted to non-employees and directors that were outstanding as of August 31, 2017, were also exercisable as of August 31,2017. As of August 31, 2017, there were $196 of unrecognized compensation costs related to non-vested non-employee options. Theunrecognized compensation costs are expected to be recognized over a weighted average period of 1.5 years. F-26  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 8 - STOCK-BASED COMPENSATION (continued): m.Restricted stock units The following table summarizes the activities for unvested RSUs granted to employees and directors for the years ended August 31, 2017,2016 and 2015: Year ended August 31, 2017 2016 2015 Number of RSUs Unvested at the beginning of period 201,669 313,216 - Granted 178,120 1,000 346,704 Vested and issued (159,353) (101,459) (33,488) Forfeited (22,160) (11,088) - Outstanding at the end of the period 198,276 201, 669 313,216 Vested and unissued (see notes 8a, 8c and 8j(2)) 164,636 152,656 72,808 The Company recorded compensation costs related to RSUs of $1,064, $518 and $1,066, during the years ended August 31, 2017, 2016and 2015, respectively, related to RSU awards. As of August 31, 2017, there were $88 unrecognized compensation costs related to RSUs, to be recorded over the next 12 months. NOTE 9 - FINANCIAL INCOME AND EXPENSES a.Financial income Year ended August 31, 2017 2016 2015 Income from interest on deposits $657 $378 $160 Exchange rate differences 7 - - Income from interest on corporate bonds 128 96 8 $792 $474 $168 b.Financial expenses Year ended August 31, 2017 2016 2015 Exchange rate differences $17 $17 $3 Bank commissions 6 11 9 Other 78 65 6 $101 $93 $18 F-27  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 10 - TAXES ON INCOME: Taxes on income included in the consolidated statements of operations represent current taxes due to taxable income of the Company andits Subsidiary. a.Corporate taxation in the U.S. The applicable corporate tax rate for the Company is 35%. As of August 31, 2017, the Company has an accumulated tax loss carryforward of approximately $10,060 (as of August 31, 2016,approximately $8,945). Under U.S. tax laws, subject to certain limitations, carryforward tax losses expire 20 years after the year in whichincurred. In the case of the Company, subject to potential limitations in accordance with the relevant law, the net loss carryforward willexpire in the years 2025 through 2037. b.Corporate taxation in Israel: The Subsidiary is taxed in accordance with Israeli tax laws. The corporate tax rates applicable to 2017, 2016 and 2015 are 24%, 25% and26.5%, respectively. As of August 31, 2017, the Subsidiary has an accumulated tax loss carryforward of approximately $26,881 (as of August 31, 2016,approximately $18,580). Under the Israeli tax laws, carryforward tax losses have no expiration date. Deferred income taxes: August 31, 2017 2016 2015 In respect of: Net operating loss carryforward $9,253 $9,219 $5,750 Research and development expenses 2,046 - 906 Less - valuation allowance (11,299) (9,219) (6,656) Net deferred tax assets $- $- $- Realization of deferred tax assets is dependent upon sufficient future taxable income during the period that deductible temporarydifferences and carryforwards are expected to be available to reduce taxable income. As the achievement of required future taxable incomeis uncertain, the Company recorded a full valuation allowance. c.Loss before taxes on income and income taxes included in the income statements of operations: Year ended August 31, 2017 2016 2015 Loss before taxes on income: U.S. $1,115 $959 $1,226 Outside U.S. 8,965 8,670 6,007 $10,080 $9,629 $7,233 Taxes on income (tax benefit): Current: U.S. - (15) - Outside U.S. 400 1,350 (1) $400 $1,335 $(1) F-28  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 10 - TAXES ON INCOME (continued): Taxes on income of $400 is derived from withholding tax deducted from HTIT milestones payments, which were received during the yearended August 31, 2017, according to the License Agreement. As of August 31, 2017, the Company did not expect to reach taxable incomein the 5 years following the balance sheet date, and therefore recognized this amount as taxes on income. d.Reconciliation of the statutory tax benefit to effective tax expense Following is a reconciliation of the theoretical tax expense, assuming all income is taxed at the regular tax rates applicable to companies inthe United States, and the actual tax expense: Year ended August 31, 2017 2016 2015 Loss before income taxes as reported in the consolidated statement ofcomprehensive loss $(10,080) $(9,629) $(7,233) Statutory tax benefit (3,528) (3,370) (2,531) Increase (decrease) in income taxes resulting from: Change in the balance of the valuation allowance for deferred tax 2,080 2,563 1,599 Disallowable deductions 327 167 422 Influence of different tax rates and changes in tax rates applicable to theSubsidiary 1,121 640 510 Withholding tax, see note 10c above 400 1,350 - Uncertain tax position - (15) (1) Taxes on income (tax benefit) for the reported year $400 $1,335 $(1) e.Uncertainty in Income Taxes Accounting Standards Codification No.740 “Income Taxes” requires significant judgment in determining what constitutes an individualtax position as well as assessing the outcome of each tax position. Changes in judgment as to recognition or measurement of tax positionscan materially affect the estimate of the effective tax rate and consequently, affect the operating results of the Company. The Companyrecognizes interest and penalties related to its tax contingencies as income tax expense. The following table summarizes the activity of the Company unrecognized tax benefits: Year ended August 31, 2017 2016 2015 Balance at Beginning of Year $11 $26 27 Decrease in uncertain tax positions for the current year - (15) (1) Balance at End of Year $11 $11 $26 The CoThe Company does not expect unrecognized tax expenses to change significantly over the next 12 months. The Company is subject to U.S. Federal income tax examinations for the tax years of 2013 through 2017. The Subsidiary is subject to Israeli income tax examinations for the tax years of 2013 through 2017. F-29  ORAMED PHARMACEUTICALS INC.NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (continued)U.S. Dollars in thousands (except share and per share data) NOTE 10 - TAXES ON INCOME (continued): f.Valuation Allowance Rollforward Year ended August 31, Balance atbeginning ofperiod Additions Balance at endof period Allowance in respect of carryforward tax losses: Year ended August 31, 2017 $9,219 $2,080 $11,299 Year ended August 31, 2016 $6,656 2,563 9,219 Year ended August 31, 2015 $5,578 $1,078 $6,656 NOTE 11 - RELATED PARTIES - TRANSACTIONS: a.During each of the fiscal years of 2017, 2016 and 2015 the Company paid to directors $100, $92 and $47, respectively, as directors' fees. b.On July 1, 2008, the Subsidiary entered into two consulting agreements with KNRY Ltd. (“KNRY”), an Israeli company owned by the CEO,whereby the CEO and the CSO, through KNRY, provide services to the Company (the “Consulting Agreements”). The ConsultingAgreements are both terminable by either party upon 60 days prior written notice. The Consulting Agreements, as amended, provide thatKNRY will be reimbursed for reasonable expenses incurred in connection with performance of the Consulting Agreements and that themonthly consulting fee paid to the CEO and the CSO is NIS 127,570 ($35) and NIS 80,454 ($22), respectively. c.Balances with related parties: August 31, 2017 2016 Accounts payable and accrued expenses - KNRY $- $48 d.Expenses to related parties: Year ended August 31, 2017 2016 2015 KNRY $868 $839 $586 F-30  All other schedules for which provision is made in the applicable accounting regulations of the SEC are not required under the related instructions,or are inapplicable, and therefore have been omitted. (b)Exhibits 3.1* Composite Copy of Certificate of Incorporation, as amended as of January 22, 2013, corrected February 8, 2013, further amended July 25, 2014and corrected September 5, 2017. 3.2 Amended and Restated By-laws (incorporated by reference from our current report on Form 8-K filed February 1, 2013). 4.1 Specimen Common Stock Certificate (incorporated by reference from our registration statement on Form S-1 filed February 1, 2013). 4.2 Form of Common Stock Purchase Warrant between Oramed Pharmaceuticals Inc. and the purchasers party thereto (incorporated by referencefrom our quarterly report on Form 10-Q filed July 1, 2015). 10.1+ Consulting Agreement by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, for the services of Nadav Kidron(incorporated by reference from our current report on Form 8-K filed July 2, 2008, File No. 000-50298). 10.2+ Amendment, dated July 13, 2013, to Consulting Agreement by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008 forthe services of Nadav Kidron (incorporated by reference from our annual report on Form 10-K filed November 14, 2014). 10.3+ Amendment, dated November 13, 2014, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1,2008, for the services of Nadav Kidron and Miriam Kidron (incorporated by reference from our annual report on Form 10-K filed November 14,2014). 10.4+ Amendment, dated July 21, 2015, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, forthe services of Nadav Kidron (incorporated by reference from our annual report on Form 10-K filed November 25, 2015). 10.5+ Amendment, dated June 27, 2016, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, forthe services of Nadav Kidron (incorporated by reference from our annual report on Form 10-K filed November 25, 2016). 10.6+ Amendment, dated November 28, 2016, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1,2008, for the services of Nadav Kidron (incorporated by reference from our quarterly report on Form 10-Q filed January 11, 2017). 10.7+ Consulting Agreement by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, for the services of Miriam Kidron(incorporated by reference from our current report on Form 8-K filed July 2, 2008, File No. 000-50298). 55  10.8+ Amendment, dated July 13, 2013, to Consulting Agreement by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008 forthe services of Miriam Kidron (incorporated by reference from our annual report on Form 10-K filed November 14, 2014). 10.9+ Amendment, dated July 21, 2015, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, forthe services of Miriam Kidron (incorporated by reference from our annual report on Form 10-K filed November 25, 2015). 10.10+ Amendment, dated June 27, 2016, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, forthe services of Miriam Kidron (incorporated by reference from our annual report on Form 10-K filed November 25, 2016). 10.11+* Amendment, dated June 30, 2017, to Consulting Agreements by and between Oramed Ltd. and KNRY, Ltd., entered into as of July 1, 2008, forthe services of Miriam Kidron. 10.12+ Oramed Pharmaceuticals Inc. Second Amended and Restated 2008 Stock Incentive Plan (incorporated by reference from our definitive proxystatement on Schedule 14A filed August 4, 2016). 10.13+ Form of Restricted Stock Unit Notice and Restricted Stock Unit Agreement (incorporated by reference from our annual report on Form 10-Kfiled November 14, 2014). 10.14+* Form of Restricted Stock Unit Notice and Restricted Stock Unit Agreement between the Company and the CSO or CEO. 10.15+ Form of Notice of Stock Option Award and Stock Option Award Agreement (incorporated by reference from our current report on Form 8-Kfiled July 2, 2008, File No. 000-50298). 10.16+ Amended and Restated Employment Agreement, dated as of July 20, 2017, by and between Oramed Ltd. and Hilla Eisenberg (incorporated byreference from our current report on Form 8-K filed July 21, 2017). 10.17+ Consulting Agreement, dated as of March 1, 2017, by and between Oramed Ltd. and Ronald Law (incorporated by reference from our currentreport on Form 8-K filed March 21, 2017). 10.18+ Clinical Trial Agreement, dated September 11, 2011, between Oramed Ltd., Hadasit Medical Research Services and Development Ltd., MiriamKidron and Daniel Schurr (incorporated by reference from our annual report on Form 10-K/A filed December 21, 2012). 10.19+ Clinical Trial Agreement, dated July 8, 2009, between Oramed Ltd., Hadasit Medical Research Services and Development Ltd., Miriam Kidronand Itamar Raz (incorporated by reference from our current report on Form 8-K filed July 9, 2009, File No. 000-50298). 10.20 Agreement, dated January 7, 2009, between Oramed Pharmaceuticals Inc. and Hadasit Medical Research Services and Development Ltd.(incorporated by reference from our current report on Form 8-K filed January 7, 2009, File No. 000-50298). 10.21 Manufacturing and Clinical Supply Agreement, dated July 5, 2010, between Oramed Ltd. and Sanofi-Aventis Deutschland GMBH(incorporated by reference from our current report on Form 8-K filed July 14, 2010, File No. 000-50298). 10.22 Patent Transfer Agreement, dated February 22, 2011, between Oramed Ltd. and Entera Bio Ltd. (incorporated by reference from our registrationstatement on Form S-1 filed March 25, 2011, File No. 333-173058). 10.23+* Representative Form of Indemnification Agreements between Oramed Pharmaceuticals Inc. and each of our directors and officers. 56  10.24+ Letter Agreement, dated as of February 5, 2013, between Oramed Pharmaceuticals Inc. and Regals Capital LP (incorporated by reference fromour annual report on Form 10-K filed November 25, 2016). 10.25+ Employment Agreement, dated April 14, 2013, between Oramed Ltd. and Joshua Hexter (incorporated by reference from our current report onForm 8-K filed April 16, 2013). 10.26+ Amendment to Employment Agreement, dated July 21, 2015, between Oramed Ltd. and Joshua Hexter (incorporated by reference from ourannual report on Form 10-K filed November 25, 2015). 10.27+ Amendment to Employment Agreement, dated June 27, 2016, between Oramed Ltd. and Joshua Hexter (incorporated by reference from ourannual report on Form 10-K filed November 25, 2016). 10.28 Securities Purchase Agreement, dated November 3, 2014, between Oramed Pharmaceuticals Inc. and Guangxi Wuzhou Pharmaceutical (Group)Co., Ltd. (incorporated by reference from our current report on Form 8-K filed November 4, 2014). 10.29 Securities Purchase Agreement, dated November 30, 2015, between Oramed Pharmaceuticals, Inc. and Hefei Tianhui Incubator of TechnologiesCo., Ltd. (incorporated by reference from Schedule 13D/A filed by Nadav Kidron on December 29, 2015). 10.30 Amended and Restated Technology License Agreement, dated December 21, 2015, between Hefei Tianhui Incubator of Technologies Co., Ltd.,Oramed Pharmaceuticals, Inc. and Oramed Ltd. (Confidential treatment has been granted for portions of this document. Incorporated byreference from our quarterly report on Form 10-Q filed January 13, 2016). 10.31 Amendment to the Amended and Restated Technology License Agreement, dated June 3, 2016, between Hefei Tianhui Incubator ofTechnologies Co., Ltd., Oramed Pharmaceuticals, Inc. and Oramed Ltd. (Confidential treatment has been requested for portions of thisdocument. The confidential portions will be omitted and filed separately, on a confidential basis, with the Securities and ExchangeCommission) (incorporated by reference from our annual report on Form 10-K filed November 25, 2016). 10.32 Amendment to the Amended and Restated Technology License Agreement, dated July 24, 2016, between Hefei Tianhui Incubator ofTechnologies Co., Ltd., Oramed Pharmaceuticals, Inc. and Oramed Ltd. (Confidential treatment has been requested for portions of thisdocument. The confidential portions will be omitted and filed separately, on a confidential basis, with the Securities and ExchangeCommission) (incorporated by reference from our annual report on Form 10-K filed November 25, 2016). 10.33 Service Agreement, dated as of June 3, 2016, between Oramed Ltd. and XERTECS GmbH (Confidential treatment has been requested forportions of this document. The confidential portions will be omitted and filed separately, on a confidential basis, with the Securities andExchange Commission) (incorporated by reference from our annual report on Form 10-K filed November 25, 2016). 10.34 General Technical Agreement between Oramed Ltd. and Premas Biotech Pvt. Ltd., dated July 24, 2016 (Confidential treatment has beenrequested for portions of this document. The confidential portions will be omitted and filed separately, on a confidential basis, with theSecurities and Exchange Commission) (incorporated by reference from our annual report on Form 10-K filed November 25, 2016). 10.35 At the Market Issuance Sales Agreement, dated April 2, 2015, by and between Oramed Pharmaceuticals Inc. and MLV & CO. LLC.(incorporated by referenced from our quarterly report on Form 10-Q filed April 3, 2015). 10.36 Amendment No. 1 to At-The-Market Issuance Sales Agreement, dated April 5, 2017, among FBR Capital Markets & Co., MLV & Co. LLC andOramed Pharmaceuticals Inc. (incorporated by reference from our quarterly report on Form 10-Q filed April 5, 2017). 57  21.1 Subsidiary (incorporated by reference from our annual report on Form 10-K filed November 27, 2013). 23.1* Consent of Kesselman & Kesselman, Independent Registered Public Accounting Firm. 31.1* Certification Statement of the Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, asamended. 31.2* Certification Statement of the Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, asamended. 32.1** Certification Statement of the Principal Executive Officer pursuant to 18 U.S.C. Section 1350. 32.2** Certification Statement of the Principal Financial Officer pursuant to 18 U.S.C. Section 1350. 101.1* The following financial statements from the Company’s annual report on Form 10-K for the year ended August 31, 2017, formatted in XBRL(eXtensible Business Reporting Language): (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Comprehensive Loss, (iii)Consolidated Statements of Changes in Stockholders’ Equity, (iv) Consolidated Statements of Cash Flows and (v) the Notes to ConsolidatedFinancial Statements, tagged as blocks of text and in detail. *Filed herewith.**Furnished herewith.+Management contract or compensation plan. ITEM 16. FORM 10-K SUMMARY. None. 58  SIGNATURES Pursuant to the requirements of Section 13 or 15 (d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed onits behalf by the undersigned, thereunto duly authorized. ORAMED PHARMACEUTICALS INC. /s/ NADAV KIDRON Nadav Kidron, President and Chief Executive Officer Date: November 29, 2017 59  Pursuant to the requirements of the Securities and Exchange Act of 1934, this report has been signed below by the following persons on behalf of theregistrant and in the capacities and on the dates indicated. /s/ NADAV KIDRON November 29, 2017Nadav Kidron, President and Chief Executive Officer and Director (principal executive officer) /s/ HILLA EISENBERG November 29, 2017Hilla Eisenberg, Chief Financial Officer (principal financial and accounting officer) Aviad Friedman, Director /s/ MIRIAM KIDRON November 29, 2017Miriam Kidron, Director Xiaopeng Li, Director /s/ KEVIN RAKIN November 29, 2017Kevin Rakin, Director /s/ LEONARD SANK November 29, 2017Leonard Sank, Director /s/ DAVID SLAGER November 29, 2017David Slager, Director 60Exhibit 3.1 CERTIFICATE OF INCORPORATION OF ORAMED PHARMACEUTICALS INC. As amended as of January 22, 2013corrected February 8, 2013further amended July 25, 2014and corrected September 5, 2017 FIRST: The name of the Corporation is: ORAMED PHARMACEUTICALS INC. SECOND: The address of the Corporation's registered office in the State of Delaware is 1811 Silverside Road, in the City of Wilmington, County of NewCastle, 19810. The name of its registered agent at such address is Vcorp Services, LLC. THIRD: The purpose of the Corporation is to engage in any lawful act or activity for which a corporation may be organized under the laws of theGeneral Corporation Law of the State of Delaware. FOURTH: The total number of shares of capital stock which the Corporation shall have authority to issue is thirty million (30,000,000) shares ofCommon Stock, at a par value of $0.012 per share. FIFTH: The name and address of the sole incorporator is as follows: NameAddressNadav KidronHi-Tech Park 2/5 Givat-Ram PO Box 39098 Jerusalem 91390 Israel SIXTH: Unless required by law or determined by the chairman of the meeting to be advisable, the vote by stockholders on any matter, including theelection of directors, need not be by written ballot. SEVENTH: The Corporation reserves the right to increase or decrease its authorized capital stock, or any class or series thereof, and to reclassify the same,and to amend, alter, change or repeal any provision contained in the Certificate of Incorporation under which the Corporation is organized or in anyamendment thereto, in the manner now or hereafter prescribed by law, and all rights conferred upon stockholders in said Certificate of Incorporation or anyamendment thereto are granted subject to the aforementioned reservation.  EIGHTH: The Board of Directors shall have the power at any time, and from time to time, to adopt, amend and repeal any and all By-laws of theCorporation. NINTH: To the fullest extent permitted by the Delaware General Corporation Law, as the same exists or may hereafter be amended, a director of thisCorporation shall not be personally liable to the Corporation or its stockholders for monetary damages for breach of fiduciary duty as a director. Any repealor modification of the foregoing provisions of this Article NINTH by the stockholders of the Corporation shall not adversely affect any right or protection ofa director of the Corporation existing at the time of such repeal or modification. TENTH: 1. The Corporation shall indemnify to the maximum extent permitted by law any person who was or is a party or is threatened to be made aparty to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative by reason of the fact thatsuch person is or was a director, officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer,employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys’ fees), judgments, finesand amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, all as more fully set forthin the By-laws of the Corporation, as amended or repealed from time to time. 2. The indemnification and other rights set forth in this Article TENTH shall not be deemed exclusive of any other rights to which those seekingindemnification or advancement of expenses may be entitled under any Bylaw, agreement, vote of stockholders or disinterested directors or otherwise, bothas to action in such person’s official capacity and as to action in another capacity while holding such office. 3. Any repeal or modification of the foregoing provisions of this Article TENTH by the stockholders of the Corporation shall not adversely affect any rightor protection of a director, officer, employee or agent of the Corporation existing at the time of such repeal or modification. Exhibit 10.11 AGREEMENT AND AMENDMENT NO. 5 This AGREEMENT AND AMENDMENT NO. 5 (this “Fifth Amendment”) is made this 30 day of June, 2017 by and between ORAMED Ltd., acompany incorporated under the laws of the State of Israel, # 513976712 with an address at High-Tech Park 2/4, Givat Ram, Jerusalem, Israel 93706(the “Company”), and KNRY, Ltd., a company incorporated under the laws of the State of Israel, # 513836502 with an address at 2 Elza Street, Jerusalem,Israel 93706 (the “Consultant”). WHEREAS: A. The Company and the Consultant are parties to the Agreement dated as of July 1, 2008 (the “Original Agreement”), as amended on July 17, 2013 (the“First Amendment”), on November 13, 2014 (the “Second Amendment”), on July 21, 2015 (the “Third Amendment”) and on June 26, 2017 (the “FourthAmendment” and together with the Original Agreement, and all its amendmants - the “Employment Agreement”), for services to be provided by Dr. MiriamKidron Israeli I.D. number 9665993 (“Miriam”); and B. The Company and the Consultant wish to amend the Employment Agreement to revise the terms of the Consultant compensation thereunder. NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained, the parties hereto covenant andagree as follows: 1.Amendment to Section 6. Section 6 of the Original Agreement is hereby amended and restated in its entirety to read as follows: “Compensation. Effective from January 2017 (inclusive), the Company shall pay to the Consultant in consideration for the performance of theConsulting Services, a gross monthly amount of 80,454 + VAT (approximately $23,013) (the “Consideration”), subject to the receipt by theCompany of an invoice from the Consultant. Each of the Consultant and Miriam hereby declares that neither of them has, nor shall have in thefuture, any claims or demands in respect of amounts paid prior to May 2008.” 2.Ratification. As amended hereby, the Employment Agreement is ratified and confirmed and all other terms and conditions remain in full force andeffect. [Signature page follows.]  IN WITNESS WHEREOF the parties hereto have executed this Fourt Amendment effective as of the date and year first above written. ORAMED LTD. KNRY LTD. Per:/s/ Yifat Zommer /s/ Nadav Kidron, /s/ Miriam KidronName: Yifat Zommer KNRY LTD.Title:Chief Financial Officer and Secretary Name:Nadav Kidron, Miriam Kidron Exhibit 10.14 ORAMED PHARMACEUTICALS INC.SECOND AMENDED AND RESTATED 2008 STOCK INCENTIVE PLANRestricted Stock Unit Notice Grantee Name and Address: In accordance with the Restricted Stock Unit Agreement, of which this Restricted Stock Unit Notice is a part (which together, constitute the“Customizing Information”), the Company hereby grants to the above named grantee (the “Grantee”) the following Restricted Stock Units. Grant Date: Restricted Stock Units Granted: Purchase Price, if any: Total Exercise Price: Form of Settlement: Expiration Date: Restricted Stock Unit Vesting Schedule: Percentage of Total Restricted Stock Units VestedVesting DateIncremental AmountCumulative Amount ACCEPTANCE BY GRANTEE IN WITNESS WHEREOF, the Company has caused this Restricted Stock Unit Agreement to be issued as of the date set forth above. Date: (Signature of Grantee) Notice Address: ORAMED PHARMACEUTICALS INC. a Delaware corporation By: Name: Title: CFO  ORAMED PHARMACEUTICALS INC.SECOND AMENDED AND RESTATED 2008 STOCK INCENTIVE PLAN Restricted Stock Unit Agreement This Restricted Stock Unit Agreement and the associated restricted stock unit notice (the “Customizing Information”), which CustomizingInformation is available in written or electronic form from the Chief Financial Officer of Oramed Pharmaceuticals Inc., a Delaware corporation (the“Company”), is made as of the date shown as the “Grant Date” in the Customizing Information (the “Grant Date”) by and between the Company, and theindividual identified in the Customizing Information (the “Grantee”). This instrument and the Customizing Information is collectively referred to as the“Restricted Stock Unit Agreement.” WITNESSETH THAT: WHEREAS, the Company has instituted the Oramed Pharmaceuticals Inc. Second Amended and Restated 2008 Stock Incentive Plan, as amendedand in effect from time to time (the “Plan”); and WHEREAS, the Compensation Committee (the “Committee”) of the Company’s Board of Directors has authorized the grant of restricted stock units(“RSUs”) with respect to the Company’s common stock, par value $0.012 per share (“Stock”), upon the terms and conditions set forth below and pursuant tothe Plan, a copy of which is incorporated herein; NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained and for other good and valuableconsideration the receipt and adequacy of which are hereby acknowledged, the Company and the Grantee agree as follows. 1. Grant. Subject to the terms of the Plan and this Restricted Stock Unit Agreement, the Company hereby grants to the Grantee that number ofrestricted stock units (“RSUs”) equal to the corresponding number of shares of the Company’s Stock (the “Underlying Shares”) shown in the CustomizingInformation under “Restricted Stock Units Granted.” 2. Vesting. Subject to the Continuous Service (as defined in the Plan) of the Grantee, as of a “Vesting Date,” as specified in the CustomizingInformation, and the Grantee as of such date is not in violation of any confidentiality, inventions and/or non-competition agreement with the Company, all ora portion, as applicable (the “Incremental Amount,” as specified in the Customizing Information), of the RSUs shall vest on such date. For the avoidance ofdoubt, except as otherwise provided pursuant to the terms of the Plan, if the Grantee’s Continuous Service is terminated by the Company or by the Grantee forany reason, whether voluntarily or involuntarily, no RSUs granted pursuant to this Restricted Stock Unit Agreement shall vest under any circumstances onand after the date of such termination. For purposes of this Section 2, the term “Company” refers to the Company and all Subsidiaries. 3. Dividends. A Grantee shall be credited with dividend equivalents equal to the dividends the Grantee would have received if the Grantee had beenthe actual record owner of the Underlying Shares on each dividend record date on or after the Grant Date and through the date the Grantee receives asettlement pursuant to Section 4 below (the “Dividend Equivalent”). If a dividend on the stock is payable wholly or partially in stock, the DividendEquivalent representing that portion shall be in the form of additional RSUs, credited on a one-for-one basis. If a dividend on the stock is payable wholly orpartially in cash, the Dividend Equivalent representing that portion shall also be in the form of cash and a Grantee shall be treated as being credited with anycash dividends, without earnings, until settlement pursuant to Section 4 below. If a dividend on stock is payable wholly or partially in other than cash orstock, the Committee may, in its discretion, provide for such Dividend Equivalents with respect to that portion as it deems appropriate under thecircumstances. Dividend Equivalents shall be subject to the same terms and conditions as the RSUs originally awarded pursuant to this Restricted Stock UnitAgreement, and they shall vest (or, if applicable, be forfeited) as if they had been granted at the same time as the original RSU award. Dividend Equivalentsrepresenting the cash portion of a dividend on stock shall be settled in cash. 2  4. Delivery of Underlying Shares and Dividend Equivalent Settlement. With respect to any RSUs that become vested RSUs as of a Vesting Datepursuant to Section 2, subject to the Grantee's delivery of a written notice to the Company, which may be by electronic email (the date of such notice is the“Settlement Date”), and only following the Settlement Date, the Company shall issue and deliver to the Grantee as soon as practicable following theSettlement Date, (a) the number of Underlying Shares indicated in such written notice and (b) the amount (and in the form) due with respect to the DividendEquivalents applicable to such Underlying Shares. The Grantee may request issuance of Underlying Shares with respect to any vested RSUs in one or moreinstallments, from time to time, provided that the Settlement Date must be on or before the tenth anniversary of the grant date of the applicable RSUs (the“Final Settlement Date”). If the Grantee has not delivered a written notice regarding settlement on or before the Final Settlement Date, then the RSUs thathave not yet been settled shall expire. Additional provisions set forth the Plan with respect to options, including Section 9 thereof, shall apply to the RSUsmutatis mutandis, as the Company may determine to be applicable. Any shares issued pursuant to this Restricted Stock Unit Agreement shall be issued, without issue or transfer tax, by delivering a stock certificate orcertificates for such shares out of theretofore authorized but unissued shares or treasury shares of its stock as the Company may elect; provided, however, thatthe time of such delivery may be postponed by the Company for such period as may be required for it with reasonable diligence to comply with anyapplicable requirements of law. Notwithstanding the prior sentence, delivery of Underlying Shares shall be made only if the required purchase pricedesignated as the “Purchase Price” shown in the Customizing Information per underlying RSU is paid to the Company. Such payment may be made either (i)by means of payment acceptable to the Company in accordance with the terms of the Plan or (ii) by a reduction in the number of shares of stock, valued at itsFair Market Value (as defined in the Plan), issued hereunder equal in each case to the aggregate Purchase Price due. If the Grantee fails to pay for or acceptdelivery of all of the shares, the right to shares of stock provided pursuant to this RSU may be terminated by the Company. 5. Withholding Taxes. The Grantee hereby agrees, as a condition of the award of RSUs, to provide to the Company an amount sufficient to satisfythe Company’s obligation to withhold federal, state, local and other taxes arising by reason of the issuance, vesting or settlement of RSUs and DividendEquivalents (the “Withholding Amount”), if any, by (a) authorizing the Company and/or any Subsidiary to withhold the Withholding Amount from theGrantee’s cash compensation or (b) remitting the Withholding Amount to the Company in cash; provided, however, that to the extent that the WithholdingAmount is not provided by one or a combination of such methods, the Company may at its election withhold from the Underlying Shares and DividendEquivalents that would otherwise be delivered that number of shares (and/or cash) having a Fair Market Value on the date of vesting sufficient to eliminateany deficiency in the Withholding Amount; and provided, further, that the Fair Market Value of shares withheld shall not exceed an amount in excess of theminimum required withholding. 3  6. Non-assignability of RSUs and Dividend Equivalents. RSUs and Dividend Equivalents shall not be assignable or transferable by the Granteeexcept by will or by the laws of descent and distribution or as permitted by the Committee in its discretion pursuant to the terms of the Plan. During the life ofthe Grantee, delivery of shares of stock and Dividend Equivalents shall be made only to the Grantee, to a conservator or guardian duly appointed for theGrantee by reason of the Grantee’s incapacity or to the person appointed by the Grantee in a durable power of attorney acceptable to the Company’s counsel. 7. Compliance with Securities Act; Lock-Up Agreement. The Company shall not be obligated to sell or issue any Underlying Shares or othersecurities in settlement of RSUs and Dividend Equivalents hereunder unless the shares of stock or other securities are at that time effectively registered orexempt from registration under the Securities Act and applicable state securities laws. In the event shares or other securities shall be delivered that shall notbe so registered, the Grantee hereby represents, warrants and agrees that the Grantee will receive such shares or other securities for investment and not with aview to their resale or distribution, and will execute an appropriate investment letter satisfactory to the Company and its counsel. The Grantee further herebyagrees that as a condition to the settlement of RSUs and Dividend Equivalents, the Grantee will execute an agreement in a form acceptable to the Company tothe effect that the shares shall be subject to any underwriter’s lock-up agreement in connection with a public offering of any securities of the Company thatmay from time to time apply to shares held by officers and employees of the Company, and such agreement or a successor agreement must be in full force andeffect. 8. Legends. The Grantee hereby acknowledges that the stock certificate or certificates evidencing shares of stock or other securities issued pursuantto any settlement of an RSU or Dividend Equivalent hereunder may bear a legend setting forth the restrictions on their transferability described in Section 7hereof, if such restrictions are then in effect. 9. Rights as Stockholder. The Grantee shall have no rights as a stockholder with respect to any RSUs, Dividend Equivalents or Underlying Sharesuntil the date of issuance of a stock certificate for Underlying Shares and any Dividend Equivalents. Except as provided by Section 3, no adjustment shall bemade for any rights for which the record date is prior to the date such stock certificate is issued, except to the extent the Committee so provides, pursuant tothe terms of the Plan and upon such terms and conditions it may establish. 4  10. Termination or Amendment of Plan. The Board may terminate or amend the Plan at any time. No such termination or amendment will affectrights and obligations under this Restricted Stock Unit Agreement, to the extent it is then in effect. 11. Effect Upon Employment and Performance of Services. Nothing in this Restricted Stock Unit Agreement or the Plan shall be construed to imposeany obligation upon the Company or any Subsidiary to employ or utilize the services of the Grantee or to retain the Grantee in its employ or to engage orretain the services of the Grantee. 12. Time for Acceptance. Unless the Grantee shall evidence acceptance of this Restricted Stock Unit Agreement by electronic or other meansprescribed by the Committee within thirty (30) days after its delivery, the RSUs and Dividend Equivalents shall be null and void (unless waived by theCommittee). 13. Section 409A of the Internal Revenue Code. The RSUs and Dividend Equivalents granted hereunder are intended to avoid the potential adversetax consequences to the Grantee of Section 409A of the Code, as defined in the Plan, and the Committee may make such modifications to this Agreement as itdeems necessary or advisable to avoid such adverse tax consequences. 14. Adjustment Upon Changes in Capitalization. Subject to any required action by the stockholders of the Company, the number of UnderlyingShares shall be proportionately adjusted for (i) any increase or decrease in the number of issued shares of Stock resulting from a stock split, reverse stock split,stock dividend, combination or reclassification of the Stock, or similar transaction affecting the Stock, (ii) any other increase or decrease in the number ofissued shares of Stock effected without receipt of consideration by the Company, or (iii) any other transaction with respect to Stock including a corporatemerger, consolidation, acquisition of property or stock, separation (including a spin-off or other distribution of stock or property), reorganization, liquidation(whether partial or complete) or any similar transaction. 15. General Provisions. (a) Amendment; Waivers. This Restricted Stock Unit Agreement, including the Plan, contains the full and complete understanding and agreementof the parties hereto as to the subject matter hereof, and except as otherwise permitted by the express terms of the Plan and this Restricted Stock UnitAgreement, it may not be modified or amended nor may any provision hereof be waived without a further written agreement duly signed by each of theparties; provided, however, that a modification or amendment that does not materially diminish the rights of the Grantee hereunder, as they may existimmediately before the effective date of the modification or amendment, shall be effective upon written notice of its provisions to the Grantee. The waiverby either of the parties hereto of any provision hereof in any instance shall not operate as a waiver of any other provision hereof or in any other instance.The Grantee shall have the right to receive, upon request, a written confirmation from the Company of the Customizing Information. 5  (b) Binding Effect. This Restricted Stock Unit Agreement shall inure to the benefit of and be binding upon the parties hereto and their respectiveheirs, executors, administrators, representatives, successors and assigns. (c) Fractional RSUs, Underlying Shares and Dividend Equivalents. All fractional Underlying Shares and Dividend Equivalents settled in stockresulting from the application of the Vesting Schedule or the adjustment provisions contained in the Plan shall be rounded down to the nearest wholeshare. If Dividend Equivalents are settled in cash, the amount paid shall be rounded down to the nearest penny. (d) Governing Law. This Restricted Stock Unit Agreement shall be governed by and construed in accordance with the laws of the State ofDelaware, without regard to the principles of conflicts of law. (e) Construction. This Restricted Stock Unit Agreement is to be construed in accordance with the terms of the Plan. In case of any conflictbetween the Plan and this Restricted Stock Unit Agreement, the Plan shall control. The titles of the sections of this Restricted Stock Unit Agreement andof the Plan are included for convenience only and shall not be construed as modifying or affecting their provisions. The masculine gender shall includeboth sexes; the singular shall include the plural and the plural the singular unless the context otherwise requires. Capitalized terms not defined hereinshall have the meanings given to them in the Plan. (f) Data Privacy. By entering into this Restricted Stock Unit Agreement and except as otherwise provided in any data transfer agreement enteredinto by the Company, the Grantee: (i) authorizes the Company, and any agent of the Company administering the Plan or providing Plan recordkeepingservices, to disclose to the Company such information and data as the Company shall request in order to facilitate the administration of the Plan; (ii)waives any data privacy rights the Grantee may have with respect to such information; and (iii) authorizes the Company to store and transmit suchinformation in electronic form. For purposes of this Section 14(f), the term “Company” refers to the Company and each of its Subsidiaries. (g) Notices. Any notice in connection with this Restricted Stock Unit Agreement shall be deemed to have been properly delivered if it isdelivered in the form specified by the Committee as follows: To the Grantee:Last address provided to the Company To the Company:Hilla Eisenberg – CFO Oramed Pharmaceuticals Inc.Hi-Tech Park 2/5, Givat-Ram PO Box 39098 Jerusalem 91390, Israel Fax2mail: +972 73 714 6872 Email: hilla@oramed.com 6 Exhibit 10.23 INDEMNIFICATION AGREEMENT THIS INDEMNIFICATION AGREEMENT (the “Agreement”) is made and entered into as of August 30, 2016 between Oramed PharmaceuticalsInc., a Delaware corporation (the “Company”), and Kevin Rakin (“Indemnitee”). WHEREAS, highly competent persons have become more reluctant to serve corporations as directors or officers unless they are provided withadequate protection through insurance or adequate indemnification against inordinate risks of claims and actions against them arising out of their service toand activities on behalf of the corporation; WHEREAS, the By-laws and/or the Certificate of Incorporation of the Company require indemnification of the officers and directors of theCompany. Indemnitee may also be entitled to indemnification pursuant to the General Corporation Law of the State of Delaware (“DGCL”). The By-lawsand/or Certificate of Incorporation and the DGCL expressly provide that the indemnification provisions set forth therein are not exclusive, and therebycontemplate that contracts may be entered into between the Company and members of the Board of Directors of the Company (the “Board”) officers andother persons with respect to indemnification; WHEREAS, the Board has determined that the increased difficulty in attracting and retaining such persons is detrimental to the best interests of theCompany's stockholders and that the Company should act to assure such persons that there will be increased certainty of such protection in the future; WHEREAS, it is reasonable, prudent and necessary for the Company contractually to obligate itself to indemnify, and to advance expenses onbehalf of, such persons to the fullest extent permitted by applicable law so that they will serve or continue to serve the Company free from undue concern thatthey will not be so indemnified; WHEREAS, this Agreement is a supplement to and in furtherance of the By-laws and/or Certificate of Incorporation of the Company and anyresolutions adopted pursuant thereto, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder; and NOW, THEREFORE, in consideration of Indemnitee’s agreement to serve as an officer and director from and after the date hereof, the parties heretoagree as follows: 1. Indemnity of Indemnitee. The Company hereby agrees to hold harmless and indemnify Indemnitee to the fullest extent permitted bylaw, as such may be amended from time to time. In furtherance of the foregoing indemnification, and without limiting the generality thereof: (a) Proceedings Other Than Proceedings by or in the Right of the Company. Indemnitee shall be entitled to the rights ofindemnification provided in this Section l(a) if, by reason of his Corporate Status (as hereinafter defined), the Indemnitee is, or is threatened to be made, aparty to or participant in any Proceeding (as hereinafter defined) other than a Proceeding by or in the right of the Company. Pursuant to this Section 1(a),Indemnitee shall be indemnified against all Expenses (as hereinafter defined), judgments, penalties, fines and amounts paid in settlement actually andreasonably incurred by him, or on his behalf, in connection with such Proceeding or any claim, issue or matter therein, if the Indemnitee acted in good faithand in a manner the Indemnitee reasonably believed to be in or not opposed to the best interests of the Company, and with respect to any criminalProceeding, had no reasonable cause to believe the Indemnitee’s conduct was unlawful. 1  (b) Proceedings by or in the Right of the Company. Indemnitee shall be entitled to the rights of indemnification provided in thisSection 1(b) if, by reason of his Corporate Status, the Indemnitee is, or is threatened to be made, a party to or participant in any Proceeding brought by or inthe right of the Company. Pursuant to this Section 1(b), Indemnitee shall be indemnified against all Expenses, judgments, penalties, fines and amounts paidin settlement actually and reasonably incurred by the Indemnitee, or on the Indemnitee’s behalf, in connection with such Proceeding if the Indemnitee actedin good faith and in a manner the Indemnitee reasonably believed to be in or not opposed to the best interests of the Company; provided, however, ifapplicable law so provides, no indemnification against such Expenses shall be made in respect of any claim, issue or matter in such Proceeding as to whichIndemnitee shall have been adjudged to be liable to the Company unless and to the extent that the Court of Chancery of the State of Delaware shalldetermine that such indemnification may be made. (c) Indemnification for Expenses of a Party Who is Wholly or Partly Successful. Notwithstanding any other provision of thisAgreement, to the extent that Indemnitee is, by reason of his Corporate Status, a party to and is successful, on the merits or otherwise, in any Proceeding, heshall be indemnified to the maximum extent permitted by law, as such may be amended from time to time, against all Expenses, judgments, penalties, finesand amounts paid in settlement actually and reasonably incurred by him or on his behalf in connection therewith. If Indemnitee is not wholly successful insuch Proceeding but is successful, on the merits or otherwise, as to one or more but less than all claims, issues or matters in such Proceeding, the Companyshall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or on his behalf in connection with each successfully resolvedclaim, issue or matter. For purposes of this Section and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal,with or without prejudice, shall be deemed to be a successful result as to such claim, issue or matter. 2. Additional Indemnity. In addition to, and without regard to any limitations on, the indemnification provided for in Section 1 of thisAgreement, the Company shall and hereby does indemnify and hold harmless Indemnitee against all Expenses, judgments, penalties, fines and amounts paidin settlement actually and reasonably incurred by him or on his behalf if, by reason of his Corporate Status, he is, or is threatened to be made, a party to orparticipant in any Proceeding (including a Proceeding by or in the right of the Company), including, without limitation, all liability arising out of thenegligence or active or passive wrongdoing of Indemnitee. The only limitation that shall exist upon the Company’s obligations pursuant to this Agreementshall be that the Company shall not be obligated to make any payment to Indemnitee that is finally determined (under the procedures, and subject to thepresumptions, set forth in Sections 5 and 6 hereof) to be unlawful. 2  3. Contribution. (a) Whether or not the indemnification provided in Sections 1 and 2 hereof is available in respect of any threatened, pending orcompleted Proceeding in which the Company is jointly liable with Indemnitee (or would be if joined in such action, suit or proceeding), the Company shallpay, in the first instance, the entire amount of any judgment or settlement of such Proceeding without requiring Indemnitee to contribute to such paymentand the Company hereby waives and relinquishes any right of contribution it may have against Indemnitee. The Company shall not enter into any settlementof any Proceeding in which the Company is jointly liable with Indemnitee (or would be if joined in such Proceeding) unless such settlement provides for afull and final release of all claims asserted against Indemnitee. (b) Without diminishing or impairing the obligations of the Company set forth in the preceding subparagraph, if, for any reason,Indemnitee shall elect or be required by law to pay all or any portion of any judgment or settlement in any threatened, pending or completed Proceeding inwhich the Company is jointly liable with Indemnitee (or would be if joined in such Proceeding), the Company shall contribute to the amount of Expenses,judgments, fines and amounts paid in settlement actually and reasonably incurred and paid or payable by Indemnitee in proportion to the relative benefitsreceived by the Company and all officers, directors or employees of the Company, other than Indemnitee, who are jointly liable with Indemnitee (or would beif joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, from the transaction or events from which such Proceeding arose;provided, however, that the proportion determined on the basis of relative benefit may, to the extent necessary to conform to law, be further adjusted byreference to the relative fault of the Company and all officers, directors or employees of the Company other than Indemnitee who are jointly liable withIndemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, in connection with the transaction or events thatresulted in such Expenses, judgments, fines or settlement amounts, as well as any other equitable considerations which applicable law may require to beconsidered. The relative fault of the Company and all officers, directors or employees of the Company, other than Indemnitee, who are jointly liable withIndemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, shall be determined by reference to, among otherthings, the degree to which their actions were motivated by intent to gain personal profit or advantage, the degree to which their liability is primary orsecondary and the degree to which their conduct is active or passive. (c) The Company hereby agrees to fully indemnify and hold Indemnitee harmless from any claims of contribution which may bebrought by officers, directors or employees of the Company, other than Indemnitee, who may be jointly liable with Indemnitee. (d) To the fullest extent permissible under applicable law, if the indemnification provided for in this Agreement is unavailable toIndemnitee for any reason whatsoever, the Company, in lieu of indemnifying Indemnitee, shall contribute to the amount incurred by Indemnitee, whether forjudgments, fines, penalties, excise taxes, amounts paid or to be paid in settlement and/or for Expenses, in connection with any claim relating to anindemnifiable event under this Agreement, in such proportion as is deemed fair and reasonable in light of all of the circumstances of such Proceeding in orderto reflect (i) the relative benefits received by the Company and Indemnitee as a result of the event(s) and/or transaction(s) giving cause to such Proceeding;and/or (ii) the relative fault of the Company (and its directors, officers, employees and agents) and Indemnitee in connection with such event(s) and/ortransaction(s). 3  3. Indemnification for Expenses of a Witness. Notwithstanding any other provision of this Agreement, to the extent that Indemnitee is,by reason of his Corporate Status, a witness, or is made (or asked) to respond to discovery requests, in any Proceeding to which Indemnitee is not a party, heshall be indemnified against all Expenses actually and reasonably incurred by him or on his behalf in connection therewith. 4. Advancement of Expenses. Notwithstanding any other provision of this Agreement, the Company shall advance all Expenses incurredby or on behalf of Indemnitee in connection with any Proceeding by reason of Indemnitee’s Corporate Status within thirty (30) days after the receipt by theCompany of a statement or statements from Indemnitee requesting such advance or advances from time to time, whether prior to or after final disposition ofsuch Proceeding. Such statement or statements shall reasonably evidence the Expenses incurred by Indemnitee and shall include or be preceded oraccompanied by a written undertaking by or on behalf of Indemnitee to repay any Expenses advanced if it shall ultimately be determined by a final judicialdetermination (as to which all rights of appeal therefrom have been exhausted or lapsed) that Indemnitee is not entitled to be indemnified against suchExpenses. Any advances and undertakings to repay pursuant to this Section 4 shall be unsecured and interest free. 5. Procedures and Presumptions for Determination of Entitlement to Indemnification. It is the intent of this Agreement to secure forIndemnitee rights of indemnity that are as favorable as may be permitted under the DGCL and public policy of the State of Delaware. Accordingly, the partiesagree that the following procedures and presumptions shall apply in the event of any question as to whether Indemnitee is entitled to indemnification underthis Agreement: (a) To obtain indemnification under this Agreement, Indemnitee shall submit to the Company a written request, including thereinor therewith such documentation and information as is reasonably available to Indemnitee and is reasonably necessary to determine whether and to whatextent Indemnitee is entitled to indemnification, provided that Indemnitee shall not be required to provide any documentation or information which isprivileged or otherwise protected from disclosure. The Secretary of the Company shall, promptly upon receipt of such a request for indemnification, advisethe Board in writing that Indemnitee has requested indemnification. Notwithstanding the foregoing, any failure of Indemnitee to provide such a request to theCompany, or to provide such a request in a timely fashion, shall not relieve the Company of any liability that it may have to Indemnitee unless, and to theextent that, such failure actually and materially prejudices the interests of the Company. (b) Upon written request by Indemnitee for indemnification pursuant to the first sentence of Section 5(a) hereof, a determinationwith respect to Indemnitee’s entitlement thereto shall be made in the specific case by one of the following four methods, which shall be at the election ofIndemnitee, in his sole discretion: (1) by a majority vote of the disinterested directors, even though less than a quorum, (2) by a majority vote of a committeeof disinterested directors designated by a majority vote of the disinterested directors, even though less than a quorum, (3) if there are no disinteresteddirectors or if a Change of Control shall have occurred after the date hereof, by Independent Counsel in a written opinion to the Board, a copy of which shallbe delivered to the Indemnitee, or (4) by a simple majority of the stockholders of the Company voting on the matter. For purposes hereof, disinteresteddirectors are those members of the Board who are not parties to the Proceeding in respect of which indemnification is sought by Indemnitee. 4  "Change of Control" shall mean the occurrence of any of the following: (a) any “person,” as such term is currently used in Section 13(d) of the Securities Exchange Act of 1934, as amended (the“1934 Act”) (a “person”), becomes a “beneficial owner” (as such term is currently used in Rule 13d-3 promulgated underthe 1934 Act (a “Beneficial Owner”) of 30% or more of the Voting Stock (as defined below) of the Company; (b) the Board of Directors of the Company adopts any plan of liquidation providing for the distribution of all orsubstantially all of the Company’s assets; (c) all or substantially all of the assets or business of the Company are disposed of in any one or more transactionspursuant to a sale, merger, consolidation or other transaction (unless the shareholders of the Company immediately priorto such sale, merger, consolidation or other transaction beneficially own, directly or indirectly, in substantially the sameproportion as they owned the Voting Stock of the Company, more than fifty percent (50%) of the Voting Stock or otherownership interests of the entity or entities, if any, that succeed to the business of the Company); (d) the Company combines with another company and is the surviving corporation but, immediately after thecombination, the shareholders of the Company immediately prior to the combination hold, directly or indirectly, fiftypercent (50%) or less of the Voting Stock of the combined company; or (e) Continuing Directors cease to constitute at least a majority of the Board of Directors of the Company. “Voting Stock” of any entity shall mean the issued and outstanding share capital or other securities of any class or classeshaving general voting power under ordinary circumstances, in the absence of contingencies, to elect the members of theboard of directors (or members of a similar managerial body if such entity has no board of directors) of such entity. “Continuing Director” means a director who either was a director of the Company on the Commencement Date or whobecame a director of the Company subsequent thereto and whose election, or nomination for election by the Company’sshareholders, was approved by a majority of the Continuing Directors then on the Board of Directors of the Company. 5  (c) If the determination of entitlement to indemnification is to be made by Independent Counsel pursuant to Section 5(b) hereof,the Independent Counsel shall be selected as provided in this Section 5(c). The Independent Counsel shall be selected by the Board. Indemnitee may, within10 days after such written notice of selection shall have been given, deliver to the Company a written objection to such selection; provided, however, thatsuch objection may be asserted only on the ground that the Independent Counsel so selected does not meet the requirements of “Independent Counsel” asdefined in this Agreement, and the objection shall set forth with reasonable particularity the factual basis of such assertion. Absent a proper and timelyobjection, the person so selected shall act as Independent Counsel. If a written objection is made and substantiated, the Independent Counsel selected maynot serve as Independent Counsel unless and until such objection is withdrawn or a court has determined that such objection is without merit. If, within 20days after submission by Indemnitee of a written request for indemnification pursuant to Section 5(a) hereof, no Independent Counsel shall have beenselected and not objected to, either the Company or Indemnitee may petition the Court of Chancery of the State of Delaware or other court of competentjurisdiction for resolution of any objection which shall have been made by the Indemnitee to the Company’s selection of Independent Counsel and/or for theappointment as Independent Counsel of a person selected by the court or by such other person as the court shall designate, and the person with respect towhom all objections are so resolved or the person so appointed shall act as Independent Counsel under Section 5(b) hereof. The Company shall pay any andall reasonable fees and expenses of Independent Counsel incurred by such Independent Counsel in connection with acting pursuant to Section 5(b) hereof,and the Company shall pay all reasonable fees and expenses (including those incurred by Indemnitee) incident to the procedures of this Section 5(c),regardless of the manner in which such Independent Counsel was selected or appointed. (d) In making a determination with respect to entitlement to indemnification hereunder, the person or persons or entity makingsuch determination shall presume that Indemnitee is entitled to indemnification under this Agreement. Anyone seeking to overcome this presumption shallhave the burden of proof and the burden of persuasion by clear and convincing evidence. Neither the failure of the Company (including by its directors orIndependent Counsel) to have made a determination prior to the commencement of any action pursuant to this Agreement that indemnification is proper inthe circumstances because Indemnitee has met the applicable standard of conduct, nor an actual determination by the Company (including by its directors orIndependent Counsel) that Indemnitee has not met such applicable standard of conduct, shall be a defense to the action or create a presumption thatIndemnitee has not met the applicable standard of conduct. 6  (e) Indemnitee shall be deemed to have acted in good faith if Indemnitee’s action is based on the records or books of account of theEnterprise (as hereinafter defined), including financial statements, or on information supplied to Indemnitee by the officers of the Enterprise in the course oftheir duties, or on the advice of legal counsel for the Enterprise or on information or records given or reports made to the Enterprise by an independentcertified public accountant or by an appraiser or other expert selected by the Enterprise. In addition, the knowledge and/or actions, or failure to act, of anydirector, officer, agent or employee of the Enterprise shall not be imputed to Indemnitee for purposes of determining the right to indemnification under thisAgreement. Whether or not the foregoing provisions of this Section 5(e) are satisfied, it shall in any event be presumed that Indemnitee has at all times actedin good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the Company or, with respect to any criminal Proceeding,that Indemnitee had reasonable cause to believe that his conduct was unlawful. Anyone seeking to overcome this presumption shall have the burden of proofand the burden of persuasion by clear and convincing evidence. (f) If the person, persons or entity empowered or selected under Section 5 to determine whether Indemnitee is entitled toindemnification shall not have made a determination within thirty (30) days after receipt by the Company of the request therefor, the requisite determinationof entitlement to indemnification shall be deemed to have been made and Indemnitee shall be entitled to such indemnification absent (i) a misstatement byIndemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially misleading, in connection with therequest for indemnification, or (ii) a prohibition of such indemnification under applicable law; provided, however, that such 30-day period may be extendedfor a reasonable time, not to exceed an additional thirty (30) days, if the person, persons or entity making such determination with respect to entitlement toindemnification in good faith requires such additional time to obtain or evaluate documentation and/or information relating thereto; and provided, further,that the foregoing provisions of this Section 5(f) shall not apply if the determination of entitlement to indemnification is to be made by the stockholderspursuant to Section 5(b) of this Agreement and if (A) within fifteen (15) days after receipt by the Company of the request for such determination, the Board orthe Disinterested Directors, if appropriate, resolve to submit such determination to the stockholders for their consideration at an annual meeting thereof to beheld within sixty (60) days after such receipt and such determination is made thereat, or (B) a special meeting of stockholders is called within fifteen (15)days after such receipt for the purpose of making such determination, such meeting is held for such purpose within forty (40) days after having been so calledand such determination is made thereat. (g) Indemnitee shall cooperate with the person, persons or entity making such determination with respect to Indemnitee’sentitlement to indemnification, including providing to such person, persons or entity upon reasonable advance request any documentation or informationwhich is not privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee and reasonably necessary to suchdetermination. Any Independent Counsel, member of the Board or stockholder of the Company shall act reasonably and in good faith in making adetermination regarding the Indemnitee’s entitlement to indemnification under this Agreement. Any costs or expenses (including attorneys’ fees anddisbursements) incurred by Indemnitee in so cooperating with the person, persons or entity making such determination shall be borne by the Company(irrespective of the determination as to Indemnitee’s entitlement to indemnification) and the Company hereby indemnifies and agrees to hold Indemniteeharmless therefrom. 7  (h) The Company acknowledges that a settlement or other disposition short of final judgment may be successful if it permits aparty to avoid expense, delay, distraction, disruption and uncertainty. In the event that any Proceeding to which Indemnitee is a party is resolved in anymanner other than by adverse judgment against Indemnitee (including, without limitation, settlement of such Proceeding with or without payment of moneyor other consideration) it shall be presumed that Indemnitee has been successful on the merits or otherwise in such Proceeding. Anyone seeking to overcomethis presumption shall have the burden of proof and the burden of persuasion by clear and convincing evidence. (i) The termination of any Proceeding or of any claim, issue or matter therein, by judgment, order, settlement or conviction, orupon a plea of nolo contendere or its equivalent, shall not (except as otherwise expressly provided in this Agreement) of itself adversely affect the right ofIndemnitee to indemnification or create a presumption that Indemnitee did not act in good faith and in a manner which he reasonably believed to be in or notopposed to the best interests of the Company or, with respect to any criminal Proceeding, that Indemnitee had reasonable cause to believe that his conductwas unlawful. 6. Remedies of Indemnitee. (a) In the event that (i) a determination is made pursuant to Section 5 of this Agreement that Indemnitee is not entitled toindemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 4 of this Agreement, (iii) no determination ofentitlement to indemnification is made pursuant to Section 5(b) of this Agreement within 30 days after receipt by the Company of the request forindemnification (subject to extension, as provided in Section 5(f)), (iv) payment of indemnification is not made pursuant to this Agreement within ten (10)days after receipt by the Company of a written request therefor or (v) payment of indemnification is not made within ten (10) days after a determination hasbeen made that Indemnitee is entitled to indemnification or such determination is deemed to have been made pursuant to Section 5 of this Agreement,Indemnitee shall be entitled to an adjudication in an appropriate court of the State of Delaware, or in any other court of competent jurisdiction, ofIndemnitee’s entitlement to such indemnification. Indemnitee shall commence such proceeding seeking an adjudication within 180 days following the dateon which Indemnitee first has the right to commence such proceeding pursuant to this Section 6(a). The Company shall not oppose Indemnitee’s right to seekany such adjudication. (b) In the event that a determination shall have been made pursuant to Section 5(b) of this Agreement that Indemnitee is notentitled to indemnification, any judicial proceeding commenced pursuant to this Section 6 shall be conducted in all respects as a de novo trial on the merits,and Indemnitee shall not be prejudiced by reason of the adverse determination under Section 5(b). (c) If a determination shall have been made pursuant to Section 5(b) of this Agreement that Indemnitee is entitled toindemnification, the Company shall be bound by such determination in any judicial proceeding commenced pursuant to this Section 6, absent (i) amisstatement by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s misstatement not materially misleading inconnection with the application for indemnification, or (ii) a prohibition of such indemnification under applicable law. 8  (d) In the event that Indemnitee, pursuant to this Section 6, seeks a judicial adjudication of his rights under, or to recover damagesfor breach of, this Agreement, or to recover under any directors’ and officers’ liability insurance policies maintained by the Company, the Company shall payon his behalf, in advance within ten (10) days after the receipt by the Company of a statement from Indemnitee requesting such payment, any and allexpenses (of the types described in the definition of Expenses in this Agreement) actually and reasonably incurred by him in such judicial adjudication,regardless of whether Indemnitee ultimately is determined to be entitled to such indemnification, advancement of expenses or insurance recovery. (e) The Company shall be precluded from asserting in any judicial proceeding commenced pursuant to this Section 6 that theprocedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court that the Company is bound by allthe provisions of this Agreement. The Company shall indemnify Indemnitee against any and all Expenses and, if requested by Indemnitee, shall (within ten(10) days after receipt by the Company of a written request therefore) advance, to the extent not prohibited by law, such expenses to Indemnitee, which areincurred by Indemnitee in connection with any action brought by Indemnitee for indemnification or advance of Expenses from the Company under thisAgreement or under any directors' and officers' liability insurance policies maintained by the Company, regardless of whether Indemnitee ultimately isdetermined to be entitled to such indemnification, advancement of Expenses or insurance recovery, as the case may be. (f) Notwithstanding anything in this Agreement to the contrary, no determination as to entitlement to indemnification under thisAgreement shall be required to be made prior to the final disposition of the Proceeding. 7. Non-Exclusivity; Survival of Rights; Insurance; Primacy of Indemnification; Subrogation. (a) The rights of indemnification as provided by this Agreement shall not be deemed exclusive of any other rights to whichIndemnitee may at any time be entitled under applicable law, the Certificate of Incorporation, the By-laws, any agreement, a vote of stockholders, aresolution of directors of the Company, or otherwise. No amendment, alteration or repeal of this Agreement or of any provision hereof shall limit or restrictany right of Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee in his Corporate Status prior to such amendment,alteration or repeal. To the extent that a change in the DGCL, whether by statute or judicial decision, permits greater indemnification than would be affordedcurrently under the Certificate of Incorporation, By-laws and this Agreement, it is the intent of the parties hereto that Indemnitee shall enjoy by thisAgreement the greater benefits so afforded by such change. No right or remedy herein conferred is intended to be exclusive of any other right or remedy, andevery other right and remedy shall be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or inequity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment ofany other right or remedy. 9  (b) To the extent that the Company maintains an insurance policy or policies providing liability insurance for directors, officers,employees, or agents or fiduciaries of the Company or of any other corporation, partnership, joint venture, trust, employee benefit plan or other enterprise thatsuch person serves at the request of the Company, Indemnitee shall be covered by such policy or policies in accordance with its or their terms to themaximum extent of the coverage available for any director, officer, employee, agent or fiduciary under such policy or policies. If, at the time of the receipt ofa notice of a claim pursuant to the terms hereof, the Company has directors' and officers' liability insurance in effect, the Company shall give prompt notice ofthe commencement of such proceeding to the insurers in accordance with the procedures set forth in the respective policies. The Company shall thereaftertake all necessary or desirable action to cause such insurers to pay, on behalf of the Indemnitee, all amounts payable as a result of such proceeding inaccordance with the terms of such policies. (c) In the event of any payment under this Agreement, the Company shall be subrogated to the extent of such payment to all of therights of recovery of Indemnitee (other than against the Outside Indemnitors), who shall execute all papers required and take all action necessary to securesuch rights, including execution of such documents as are necessary to enable the Company to bring suit to enforce such rights. (d) The Company hereby acknowledges that the Indemnitee may have other sources of indemnification or insurance, whethercurrently in force or established in the future (collectively, the “Outside Indemnitors”). The Company hereby agrees: (i) that it is the indemnitor of first resort(i.e., its obligations to the Indemnitee are primary and any obligation of the Outside Indemnitors to advance expenses or to provide indemnification for thesame expenses or liabilities incurred by the Indemnitee are secondary); (ii) that it shall be required to advance the full amount of Expenses incurred by theIndemnitee and shall be liable in full for all indemnifiable amounts to the extent legally permitted and as required by the Company’s Certificate ofIncorporation and Bylaws or any agreement between the Company and the Indemnitee, without regard to any rights the Indemnitee may have against theOutside Indemnitors and (iii) that it irrevocably waives, relinquishes and releases the Outside Indemnitors from any and all claims against the OutsideIndemnitors for contribution, subrogation or any other recovery of any kind in respect thereof. The Company further agrees that no advancement or paymentby the Outside Indemnitors on behalf of the Indemnitee with respect to any claim for which the Indemnitee have sought indemnification from the Companyshall affect the foregoing and the Outside Indemnitors shall have a right of contribution and/or be subrogated to the extent of such advancement or paymentto all of the rights of recovery of the Indemnitee against the Company. The Company and the Indemnitee agree that the Outside Indemnitors are express thirdparty beneficiaries of the terms hereof. (e) The Company's obligation to indemnify or advance Expenses hereunder to Indemnitee who is or was serving at the request ofthe Company as a director, officer, employee or agent of any other corporation, partnership, joint venture, trust, employee benefit plan or other enterpriseshall be reduced by any amount Indemnitee has actually received as indemnification or advancement of expenses from such other corporation, partnership,joint venture, trust, employee benefit plan or other enterprise. 10  8. Exception to Right of Indemnification. Notwithstanding any provision in this Agreement, the Company shall not be obligated underthis Agreement to make any indemnity in connection with any claim made against Indemnitee: (a) for an accounting of profits made from the purchase and sale (or sale and purchase) by Indemnitee of securities of the Companywithin the meaning of Section 16(b) of the Securities Exchange Act of 1934, as amended, or similar provisions of state statutory law or common law; or (b) in connection with any Proceeding (or any part of any Proceeding) initiated by Indemnitee, including any Proceeding (or anypart of any Proceeding) initiated by Indemnitee against the Company or its directors, officers, employees or other indemnitees, unless (i) the Board authorizedthe Proceeding (or any part of any Proceeding) prior to its initiation, (ii) the Company provides the indemnification, in its sole discretion, pursuant to thepowers vested in the Company under applicable law or (iii) such Proceeding is brought by Indemnitee to assert, interpret or enforce his rights under thisAgreement. 9. Duration of Agreement. All agreements and obligations of the Company contained herein shall continue during the periodIndemnitee is an officer or director of the Company (or is or was serving at the request of the Company as a director, officer, employee or agent of anothercorporation, partnership, joint venture, trust or other enterprise) and shall continue thereafter so long as Indemnitee shall be subject to any Proceeding (or anyproceeding commenced under Section 6 hereof) by reason of his Corporate Status, whether or not he is acting or serving in any such capacity at the time anyliability or expense is incurred for which indemnification can be provided under this Agreement. This Agreement shall be binding upon and inure to thebenefit of and be enforceable by the parties hereto and their respective successors (including any direct or indirect successor by purchase, merger,consolidation or otherwise to all or substantially all of the business or assets of the Company), assigns, spouses, heirs, executors and personal and legalrepresentatives. 10. Security. To the extent requested by Indemnitee and approved by the Board, the Company may at any time and from time to timeprovide security to Indemnitee for the Company’s obligations hereunder through an irrevocable bank line of credit, funded trust or other collateral. Any suchsecurity, once provided to Indemnitee, may not be revoked or released without the prior written consent of the Indemnitee. 11. Enforcement. (a) The Company expressly confirms and agrees that it has entered into this Agreement and assumes the obligations imposed on ithereby in order to induce Indemnitee to serve as an officer or director of the Company, and the Company acknowledges that Indemnitee is relying upon thisAgreement in serving as an officer or director of the Company. (b) This Agreement constitutes the entire agreement between the parties hereto with respect to the subject matter hereof andsupersedes all prior agreements, and understandings, oral, written and implied, between the parties hereto with respect to the subject matter hereof. 11  (c) The Company shall not seek from a court, or agree to, a "bar order" which would have the effect of prohibiting or limiting theIndemnitee's rights to receive advancement of expenses under this Agreement. 12. Definitions. For purposes of this Agreement: (a) “Corporate Status” describes the status of a person who is or was a director, officer, employee, agent or fiduciary of theCompany or any subsidiary thereof or of any other corporation, partnership, joint venture, trust, employee benefit plan or other enterprise that such person isor was serving at the express written request of the Company. (b) “Disinterested Director” means a director of the Company who is not and was not a party to the Proceeding in respect of whichindemnification is sought by Indemnitee and who is not subject to any other relationship that may reasonably prejudice such director's determination as tothe Indemnitee's entitlement to indemnification hereunder. (c) “Enterprise” shall mean the Company and any other corporation, partnership, joint venture, trust, employee benefit plan orother enterprise that Indemnitee is or was serving at the express written request of the Company as a director, officer, employee, agent or fiduciary. (d) “Expenses” shall include all reasonable attorneys’ fees, retainers, court costs, transcript costs, fees of experts, witness fees,travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees and all other disbursements or expenses of thetypes customarily incurred in connection with prosecuting, defending, preparing to prosecute or defend, investigating, participating, or being or preparing tobe a witness in a Proceeding, or responding to, or objecting to, a request to provide discovery in any Proceeding. Expenses also shall include Expensesincurred in connection with any appeal resulting from any Proceeding and any federal, state, local or foreign taxes imposed on the Indemnitee as a result ofthe actual or deemed receipt of any payments under this Agreement, including without limitation the premium, security for, and other costs relating to anycost bond, supersede as bond, or other appeal bond or its equivalent. (e) “Independent Counsel” means a law firm, or a member of a law firm, that is experienced in matters of corporation law andneither presently is, nor in the past five years has been, retained to represent: (i) the Company or Indemnitee in any matter material to either such party (otherthan with respect to matters concerning Indemnitee under this Agreement, or of other indemnitees under similar indemnification agreements), or (ii) any otherparty to the Proceeding giving rise to a claim for indemnification hereunder. Notwithstanding the foregoing, the term “Independent Counsel” shall notinclude any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of interest in representing either theCompany or Indemnitee in an action to determine Indemnitee’s rights under this Agreement. The Company agrees to pay the reasonable fees of theIndependent Counsel referred to above and to fully indemnify such counsel against any and all Expenses, claims, liabilities and damages arising out of orrelating to this Agreement or its engagement pursuant hereto. 12  (f) “Proceeding” includes any threatened, pending or completed action, suit, arbitration, alternate dispute resolution mechanism,investigation, inquiry, administrative hearing or any other actual, threatened or completed proceeding, whether brought by or in the right of the Company orotherwise and whether civil, criminal, administrative or investigative, in which Indemnitee was, is or will be involved as a party or otherwise, by reason of hisor his Corporate Status, by reason of any action taken by him or of any inaction on his part while acting in his Corporate Status; in each case whether or nothe is acting or serving in any such capacity at the time any liability or expense is incurred for which indemnification can be provided under this Agreement;including one pending on or before the date of this Agreement, but excluding one initiated by an Indemnitee pursuant to Section 6 of this Agreement toenforce his rights under this Agreement. 13. Severability. The invalidity or unenforceability of any provision hereof shall in no way affect the validity or enforceability of anyother provision. Without limiting the generality of the foregoing, this Agreement is intended to confer upon Indemnitee indemnification rights to the fullestextent permitted by applicable laws. In the event any provision hereof conflicts with any applicable law, such provision shall be deemed modified, consistentwith the aforementioned intent, to the extent necessary to resolve such conflict. 14. Modification and Waiver. No supplement, modification, termination or amendment of this Agreement shall be binding unlessexecuted in writing by both of the parties hereto. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of anyother provisions hereof (whether or not similar) nor shall such waiver constitute a continuing waiver. 15. Notice By Indemnitee. Indemnitee agrees promptly to notify the Company in writing upon being served with or otherwise receivingany summons, citation, subpoena, complaint, indictment, information or other document relating to any Proceeding or matter which may be subject toindemnification covered hereunder. The failure to so notify the Company shall not relieve the Company of any obligation which it may have to Indemniteeunder this Agreement or otherwise unless and only to the extent that such failure or delay materially prejudices the Company. 16. Notices. All notices and other communications given or made pursuant to this Agreement shall be in writing and shall be deemedeffectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal businesshours of the recipient, and if not so confirmed, then on the next business day, (c) five (5) days after having been sent by registered or certified mail, returnreceipt requested, postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with writtenverification of receipt. All communications shall be sent to Indemnitee at the address set forth below Indemnitee signature hereto, and to the Company, at itsprincipal executive offices to the attention of the President, or to such other address as may have been furnished to Indemnitee by the Company or to theCompany by Indemnitee, as the case may be. 13  17. Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all ofwhich together shall constitute one and the same Agreement. This Agreement may also be executed and delivered by facsimile signature and in two or morecounterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 18. Headings. The headings of the paragraphs of this Agreement are inserted for convenience only and shall not be deemed to constitutepart of this Agreement or to affect the construction thereof. 19. Governing Law and Consent to Jurisdiction. This Agreement and the legal relations among the parties with respect to the subjectmatter of this Agreement shall be governed by, and construed and enforced in accordance with, the laws of the State of Delaware, without regard to its conflictof laws rules. The Company and Indemnitee hereby irrevocably and unconditionally (i) agree that any action or proceeding arising out of or in connectionwith this Agreement shall be brought only in the Chancery Court of the State of Delaware (the “Delaware Court”), and not in any other state or federal courtin the United States of America or any court in any other country, (ii) consent to submit to the exclusive jurisdiction of the Delaware Court for purposes ofany action or proceeding arising out of or in connection with this Agreement, (iii) waive any objection to the laying of venue of any such action orproceeding in the Delaware Court, and (iv) waive, and agree not to plead or to make, any claim that any such action or proceeding brought in the DelawareCourt has been brought in an improper or inconvenient forum. SIGNATURE PAGE TO FOLLOW 14  IN WITNESS WHEREOF, the parties hereto have executed this Indemnification Agreement on and as of the day and year first above written. COMPANY ORAMED PHARMACEUTICALS INC. By:/s/ Nadav Kidron Name:Nadav Kidron Title:Chief Executive Officer INDEMNITEE /s/ Kevin Rakin Name:Kevin Rakin Address:36 Church Lane, Westport, CT 06880, USA 15  Schedule to Exhibit 10.23 The following executive officers and directors are each party to an Indemnification Agreement or Amended and Restated Indemnification Agreement with theCompany, each of which is substantially identical in all material respects to the representative Indemnification Agreement filed herewith and is dated as ofthe respective date listed below. Name of Signatory DateNadav Kidron March 26, 2017President, Chief Executive Officer and Director Miriam Kidron March 26, 2017Chief Medical and Technology Officer and Director Hilla Eisenberg July 20, 2017Chief Financial Officer Joshua Hexter March 26, 2017Chief Operating Officer and VP Business Development Ronald Law March 20, 2017Chief Strategy Officer Aviad Friedman March 26, 2017Director Xiaopeng Li March 26, 2017Director Leonard Sank January 26, 2017Director David Slager January 19, 2017Director 16 Exhibit 23.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (Nos. 333-215525 and 333-190497) and Form S-8 (Nos. 333-213835, 333-199120, 333-190222 and 333-163919) of Oramed Pharmaceuticals Inc. of our report dated November 29, 2017 relating to the financialstatements, which appears in this Form 10-K. Tel-Aviv, Israel/s/ Kesselman & KesselmanNovember 29, 2017Certified Public Accountants (lsr.) A member firm of PricewaterhouseCoopers International Limited Exhibit 31.1 CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO RULE 13a-14(a) AND 15d-14(a)UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED I, Nadav Kidron, certify that: 1. I have reviewed this Annual Report on Form 10-K of Oramed Pharmaceuticals Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; 3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects thefinancial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report; 4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for theregistrant and have: (a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under oursupervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by otherswithin those entities, particularly during the period in which this report is being prepared; (b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed underour supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements forexternal purposes in accordance with generally accepted accounting principles; (c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and (d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s mostrecent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely tomaterially affect, the registrant 's internal control over financial reporting; and 5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, tothe registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions): (a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and (b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internalcontrol over financial reporting. Date: November 29, 2017By:/s/ Nadav Kidron Nadav Kidron President and Chief Executive Officer Exhibit 31.2 CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO RULE 13a-14(a) AND 15d-14(a)UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED I, Hilla Eisenberg, certify that: 1. I have reviewed this Annual Report on Form 10-K of Oramed Pharmaceuticals Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; 3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects thefinancial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report; 4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined inExchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for theregistrant and have: (a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under oursupervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by otherswithin those entities, particularly during the period in which this report is being prepared; (b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed underour supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements forexternal purposes in accordance with generally accepted accounting principles; (c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and (d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s mostrecent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely tomaterially affect, the registrant 's internal control over financial reporting; and 5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, tothe registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions): (a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and (b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internalcontrol over financial reporting. Date: November 29, 2017By:/s/ Hilla Eisenberg Hilla Eisenberg Chief Financial Officer Exhibit 32.1 CERTIFICATION OF CHIEF EXECUTIVE OFFICERPURSUANT TO 18 U.S.C. SECTION 1350 In connection with the annual report of Oramed Pharmaceuticals Inc., or the Company, on Form 10-K for the period ended August 31, 2017, as filedwith the Securities and Exchange Commission on the date hereof, or the Report, I, Nadav Kidron, President, Chief Executive Officer and a Director of theCompany, certify, pursuant to 18 U.S.C. Section 1350, that to my knowledge: 1.The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and 2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. Dated: November 29, 2017/s/ Nadav Kidron Nadav KidronPresident and Chief Executive Officer Exhibit 32.2 CERTIFICATION OF CHIEF FINANCIAL OFFICERPURSUANT TO 18 U.S.C. SECTION 1350 In connection with the annual report of Oramed Pharmaceuticals Inc., or the Company, on Form 10-K for the period ended August 31, 2017, as filedwith the Securities and Exchange Commission on the date hereof, or the Report, I, Hilla Eisenberg, Chief Financial Officer of the Company, certify, pursuantto 18 U.S.C. Section 1350, that to my knowledge: 1.The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and 2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. Dated: November 29, 2017/s/ Hilla Eisenberg Hilla Eisenberg Chief Financial Officer 

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