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Rhythm Biosciences Limited

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FY2024 Annual Report · Rhythm Biosciences Limited
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2024
ANNUAL REPORT
RHYTHM BIOSCIENCES LIMITED (ASX:RHY)
ACN 619 459 335

RHYTHM’S ColoSTAT® 
IS A SIMPLE BLOOD TEST THAT DETECTS THE PROTEIN 
BIOMARKERS IN THE BLOOD, THAT ARE INDICATIVE 
OF THE PRESENCE OF COLORECTAL CANCER.
2

CONTENTS
Key Milestones.....................................................................................4
Company Overview...........................................................................6
Market Overview................................................................................7
Chairman’s Report.............................................................................8
CEO's Report.......................................................................................9
Directors’ Report............................................................................. 10
Auditor's Independence Declaration.....................................24
Consolidated Statement of Profit or 
Loss and Other Comprehensive Income..............................25
Consolidated Statement of Financial Position...................26
Consolidated Statement of Changes in Equity.................. 27
Consolidated Statement of Cash Flows................................28
Notes to the Consolidated Financial Statements .............29
Consolidated Entity Disclosure Statement .........................46
Directors’ Declaration....................................................................47
Independent Auditor’s Report..................................................48
Additional ASX Information........................................................53
Corporate Directory.......................................................................57
3

	
2003 - 2016 	
CSIRO Research and Development
	
January 2018	
Development Program Commences
	 December 2020	
Global Manufacturer Appointed
	
May 2019	
ISO Certification
	
November 2021	
CE Mark Granted for ColoSTAT®
	
May 2023	
UKCA Mark Granted and Strategic Partnership with
	
	
LINK Medical Solutions
	
Multiplex Kit Validation	
 
	
August 2024 	
Alpha Version of the Multiplex Antibody 
	
	
Detection Kits received
	
 	
Market Entry
RHYTHM BIOSCIENCES
MILESTONES
4

	
Rhythm Biosciences Lists on the ASX	
December 2017
	
Patents Secured in 21 Countries	
January 2018  -
	
 	
November 2020
	
Clinical Trial Program Commences	
February 2019
	
Clinical Trial Complete (RHY-001)	
November  2021
	 ColoSTAT® Authorised for Sale in New Zealand	
November 2022
	
Pipeline Activities - Other Cancers	
 
	
RHY001 Study - Submit Publication	
January 2024
FUTURE MILESTONES
5

References: 1. https://www.who.int/activities/promoting-cancer-early-diagnosi. 2. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11272-9. 3. https://www.who.int/news-room/
fact-sheets/detail/colorectal-cancer. 4. Gordon NP, Green BB. Factors associated with use and non-use of the Fecal Immunochemical Test (FIT) kit for Colorectal Cancer Screening in Response to a 2012 
outreach screening program: a survey study. BMC Public Health. 2015 Jun 11;15:546. 5. https://www.aihw.gov.au/reports/australias-health/cancer-screening-and-treatment. 6. Xi Y, Xu P (2021), Global 
colorectal cancer burden in 2020 and projections to 2040, Translational Oncology, 14(10),101174,doi:10.1016/j.tranon.2021.101174 Epub 2021 Jul 6. 7. https://news.cancerresearchuk.org/2023/01/24/early-
onset-cancer-why-are-more-young-adults-being-diagnosed. 8. https://bowelcancernz.org.nz/never-too-young. 9. https://www.aihw.gov.au/getmedia/ea870f59-a9e4-4772-8fa8-e1206b56a552/
cancer-data-in-australia.pdf?v=20240815054943&inline=true. 10. https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services. 11. NHS waiting 
times trends shows drastic increase in delays to bowel cancer diagnostic testing | Bowel Cancer UK. 12. Why are most colorectal cancers diagnosed outside of screening? A retrospective analysis of data 
from the English bowel screening programme - Robert Stephen Kerrison, Andrew Prentice, Sarah Marshall, Christian von Wagner, 2022 (sagepub.com). 13. The diagnostic value of symptoms for colorectal 
cancer in primary care: a systematic review | British Journal of General Practice (bjgp.org). 14. Colorectal cancer screening: a global overview of existing programmes | Gut (bmj.com). 15. An Estimate of the 
US Rate of Overuse of Screening Colonoscopy: a Systematic Review - PMC (nih.gov). 16. RACGP - New standard provides up-to-date guidance on colonoscopy referral and care. 17. Colonoscopy overuse 
in colorectal cancer screening and associated factors in Argentina: a retrospective cohort study | BMC Gastroenterology | Full Text (biomedcentral.com). 18. New study at Coventry's University Hospital 
could reduce need for colonoscopies across NHS - The Coventry Observer. 19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563245. 20. https://pursuit.unimelb.edu.au/articles/who-needs-a-
colonoscopy-most. 21. https://www.safetyandquality.gov.au/sites/default/files/migrated/2.1-Text-Colonoscopy-hospitalisations-all-ages.pdf.
ABOUT RHYTHM BIOSCIENCES
Rhythm Biosciences is committed to saving lives through early 
detection of cancers by developing and providing physicians 
simple and accurate diagnostic tools.
The World Health Organisation has reported that 30 
– 50% of cancers could be prevented1 with the early 
detection and characterisation of disease being an 
important part of the solution. As well as more timely 
information, there is a need for simple and cost-effective 
solutions that can be incorporated in health care systems 
in the developed economies as well as in the low and 
middle-income economies where most of the estimated 
9.6 million annual deaths due to cancer occur.1,2 
Rhythm Biosciences’ mission is to discover, develop and 
commercialise affordable and simple clinical diagnostic 
solutions for a broad range of cancers.
Our most advanced program is focussed on Colorectal 
Cancer (CRC), the second leading cause of cancer-
related deaths worldwide.3  In 2020, there were more 
than 1.9 million people diagnosed with CRC and over 
930,000 lives lost to the disease. By 2040, the burden of 
CRC is predicted to increase to 3.2 million new cases and 
1.6 million deaths per year. 3
Faecal immunochemical test (FIT) is the prevalent CRC 
screening method globally. Unfortunately, the utilisation 
of the FIT test is low, due to inconvenience, sample 
collection and aversion with the procedure.4 A recent 
report from Australian Institute of Health and Welfare 
has revealed overall participation for the two-year period 
2021-2022 has dropped to 40 per cent from 44 per cent 
in 2019-2020.5
Another challenge has been increasing incidence rates, 
particularly among younger people.6 In the United 
Kingdom (UK), between the 1990s and 2018, cancer 
incidence rates in 25 to 49-year-olds increased by 22% 
(> twice the 9% increase in over-75s.).7 Around 350 of 
the >3,300 diagnosed with CRC each year in NZ, are 
under the age of 50.8 For Australia, Incidence rates of 
40–49 year olds increased from 22 cases per 100,000 
people in 2005 to an estimated 30 cases in 2024.9 The 
CRC healthcare burden has led to fewer resources and 
increased delays in wait times for colonoscopies. In the 
UK there was a 40% increase from 2017 to 2018 in the 
average number of patients waiting longer than two 
weeks.10,11
Furthermore, the lack of compliance with national 
CRC screening programs results in the vast majority 
of diagnosed cancers originating from patients who 
are under screened and enter the care path through 
presentation of symptoms to their primary carer.12-14 
This often leads to unnecessary investigation by 
colonoscopy15-18 and there is a need for a mechanism, 
like an effective, low cost blood-based test, to help 
triage or prioritise those individuals awaiting endoscopy 
to reduce waiting lists.19 The Australian Commission on 
Safety and Quality in Health Care has recommended 
states and territories adopt triaging systems to prioritise 
colonoscopies for most at risk individuals.20,21
ColoSTAT® Test Kit, Rhythm Bioscience’s first simple 
blood-based cancer test, designed for the detection of 
colorectal cancer, is a solution for use within the disease 
detection pathway. There are a number of potential 
opportunities to integrate ColoSTAT® into clinical 
practice that are being explored by the company. (A) 
colonoscopy to prioritise those who should be examined 
first (B) use as an adjunct to FIT testing for vulnerable 
patients who are unable to withstand colonoscopy (C) 
inherited or familial cancer detection and (D) general 
screening alongside the current stool-based methods 
as an alternative screening test for individuals unable 
to or are unwilling to use currently available screening 
modalities.
ColoSTAT® is patented in over 20 countries, and in 
response to significant regulatory changes in Europe and 
proposed changes in Australia and the U.S. the test is 
being updated to meet IVDR (In vitro diagnostic medical 
devices regulation) regulatory standard. The updated 
development consists of a redesigned multiplex assay 
that has the potential to be of materially lower cost, 
simpler to use, and a more consistent quality through 
increased automation and reduced chance of human 
error. 
The need to detect other cancers is also real and Rhythm 
Biosciences has programs focussed on other cancers 
including gastric, lung and breast cancer. The programs 
are in the stage of further qualifying protein biomarkers 
for their utility as blood-based markers for underlying 
disease and represent a significant platform extension 
opportunity. 
6

COLORECTAL CANCER
EARLY DETECTION IS KEY TO SURVIVAL (STAGES I/II)
MODIFIABLE RISK FACTORS ASSOCIATED WITH CRC9
NON-MODIFIABLE RISK FACTORS ASSOCIATED WITH CRC9
5-YEAR SURVIVAL RATES FOR THOSE DIAGNOSED AT AN EARLY STAGE OF CRC ARE OVER 90%.8
>90%
STAGE I
A diet low in 
fibre
Personal history 
of certain types 
of cancers 
(ovarian/uterine)
High red meat 
consumption, especially 
processed meats
IBD, such as 
Crohn's and 
Ulcerative Colitis
Physical 
inactivity and 
obesity
Family history 
of CRC
Consumption 
of alcohol and 
tobacco
Type 2 
diabetes
Low blood 
level of 
Vitamin D
Aged ≥ 50
A previous 
diagnosis of 
polyps/CRC
STAGE II
STAGE III
STAGE IV
7

A MESSAGE FROM 
THE CHAIRMAN 
Otto Buttula
Dear Fellow Shareholders
On behalf of the Board, I am pleased 
to present Rhythm Biosciences’ 2024 
Annual Report.  Financial year 2024 
was once again very disappointing 
in terms of shareholder returns, with 
an ongoing and significant decrease 
in our Company’s share price. This 
follows a tumultuous 2023 calendar 
year which included senior executive 
changes, the difficult, but correct 
decision to withdraw our ColoSTAT® 
application from the Therapeutic 
Goods Administration (TGA) and 
further instability earlier this calendar 
year, with minority shareholder 
discontent seeking to alter the 
composition of the Board.
Pleasingly this is now all behind us 
and the comprehensive change 
in strategy,  announced in late 
December 2023 has been front and 
foremost in the Company’s plans for 
2024 and beyond.  This included:
•	 Appointment of a suitably 
qualified CEO to support the 
IVDR transition work, with my 
own executive status reverting to 
non-executive following a brief 
handover period.  I am pleased to 
report that this has been achieved 
with Dr David Atkins commencing 
in the CEO role as of 13 May 2024 
and myself returning to non-
executive as of 31 May 2024.  Dr 
Atkins is the most experienced 
CEO appointment since the 
Company’s inception and has had 
strong commercial experience in 
the Company’s sphere of activity, 
particularly overseas.  Dr Atkins 
will report more upon the progress 
made by the Company in his 
CEO Letter / Report, which will 
summarise current operational and 
commercialisation activities.
•	 Reclassification of previously 
produced IVDD ColoSTAT® kits to 
Research Use Only (RUO) rather 
than for commercial sales.
•	 The engagement of a US 
based Contract Manufacturing 
Organisation (CMO) to undertake 
all future design and development 
work on ColoSTAT®. The Company 
has contracted with Quansys 
Biosciences in the USA, with 
work progressing well, converting 
ColoSTAT® to a Multiplex Assay, 
meeting higher production 
standards capable of meeting 
IVDR transition work and better 
meeting end customer / user 
requirements.
•	 Implementation of a cost 
reduction program, with ongoing 
costs reducing materially in line 
with the new manufacturing 
agreement and a more targeted 
and qualified team, given much of 
the previous scientific investigative 
work has been completed.
Therefore, despite a difficult period 
being experienced, the Board and 
I believe the major problematic 
issues experienced by the Company 
are largely behind us.  This reset in 
the Company’s strategic direction 
positions the Company to take 
advantage of its potential and to 
commercialise upon what is a valuable 
intellectual property portfolio.
The Board and I sincerely believe the 
experience of Dr Atkins together, 
with the quality of the current 
personnel within the Company is 
of a high calibre and are driven to 
succeed commercially.  Hence, with 
a team now being aligned with the 
Company’s strategic goals  we  believe 
we will start to restore shareholder 
value over time.
On behalf of the Board, I would like 
to thank Dr Atkins, the executive 
management team and all our 
employees, for their ongoing 
personal commitment and diligent 
contributions to Rhythm. Our Board 
members remain focussed on 
continuing to contribute strongly to 
the Company’s success.  I would also 
acknowledge the contribution made 
by Dr Rachel David, a Non-Executive 
Director of Rhythm, who resigned 
from the Board in December 2023.
Finally, and importantly, I would 
also like to thank our many loyal 
shareholders who continue to support 
and believe in the Company. 
Rest assured, we continue to be 
driven and pursue our goal of assisting 
patients diagnose cancers early, with 
simple, inexpensive diagnostic tools.
Sincerely
Otto Buttula
Non-Executive Chairman
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
8
CHAIRMAN’S REPORT

A MESSAGE FROM 
THE CEO 
Dr David Atkins, PhD
Dear Shareholders
It’s a real pleasure and a privilege 
to be writing this first letter for our 
stakeholders, and I am delighted to be 
trusted by our board to lead Rhythm 
Biosciences on the journey from start-
up to successful, commercial scale-up 
business. 
I have had the opportunity to be a 
member of several teams engaged in 
clinical diagnostic development over 
the years and my first impressions are 
that our current team sets the standard 
of understanding the opportunity 
and responsibility that Rhythm has 
for making an impact to individuals, 
patients and their families around the 
globe. Furthermore, the entire team 
and board members have made me 
feel instantly welcome and for that I 
am grateful. I am also grateful to the 
previous members of the Rhythm 
team who have worked tirelessly for 
more than 7 years, and left the current 
team a sizeable body of high-quality 
foundational work to build on. It is true 
that we have had to take a step sideways 
in order to go forward and having a rich 
history available to us is going to allow 
acceleration towards the end goal. 
The focus for Rhythm has been 
colorectal cancer where we have the 
most developed technology. However, 
we have a wealth of additional assets in 
other cancer types and I look forward to 
continue the work with our partners to 
broaden out the commercial solutions 
that we can ultimately bring to market. 
The next 12 months is going to be an 
important phase of the company as we 
explore the new clinical opportunities 
that keeps general cancer screening as 
an end-goal but allows us to get there in 
several steps. We’re exploring different 
regulatory paths around the globe and 
building the right commercial networks 
to allow us to bring our CSIRO-
originated technology to market as soon 
as its ready. 
Being an Australian business solving an 
important global cancer challenge is a 
goal worth striving for and I look forward 
to providing a continuous flow of news 
over the coming 12 months! 
Sincerely
Dr David Atkins, PhD
CEO
9

The Directors of Rhythm Biosciences Limited (Rhythm, the Group, or the Consolidated Entity) present their report for 
the financial year ended 30 June 2024.
Directors
The Directors at any time during the year, or since the end of the financial year, were as follows:
Mr Otto Buttula 
Dr Trevor Lockett
Mr Louis (Lou) Panaccio
Ms Susan MacLeman
Dr Rachel David (resigned 28 December 2023)
Meetings of Directors	
The following table sets out the number of Director meetings of the Company held during the financial year, and the 
number of meetings attended by each Director.
Director
Directors’ Meetings
 Held
Attended
Mr O Buttula
12
12
Dr T Lockett
12
12
Mr L Panaccio
12
11
Ms S MacLeman
12
12
Dr R David
4
4
‘Held’ represents the number of meetings held during the time the Director held office during the year.
Corporate Governance
Details on the Company’s corporate governance procedures, policies and practices are at www.rhythmbio.com.
Principal Activities	
Rhythm Biosciences Limited (ASX: RHY) is an innovative Australian publicly listed medical diagnostics company with 
a focus on delivering simple, affordable blood tests for the accurate detection of cancers, providing physicians with 
accurate and reliable diagnostic tools. Its ColoSTAT® product, which is nearing the commercialisation phase aims to 
provide a simple accurate and early detection test for colorectal cancer. 
Corporate Information
Rhythm, a Company limited by shares, is incorporated and domiciled in Australia. Rhythm has prepared a consolidated 
financial report incorporating the entities that it controlled during the financial year.
The registered office and operations of the Company are located at Bio21 Institute, 30 Flemington Road, Parkville 
Victoria, Australia, 3010.
Results of Operations
The Group incurred a loss after income tax of $6,856,761 for the year ended 30 June 2024 (2023: $8,217,557) which 
reflects the research and development activity during the year. Highlights were as follows:
•	 ColoSTAT® Automation project with Nutripath and Tecan completed;
•	 Platform expansion – initial outcomes in Breast and Lung Cancer positive; 
•	 1st Tranche of R&D Tax Incentive received, new secondary submission underway;
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
10
DIRECTORS' REPORT

•	 Manuscript for ColoSTAT® clinical performance study submitted.
•	 Internationally Renowned Clinically Advisory Board established, with initial meeting held;
•	 The current patent review and renewals of ColoSTAT® in preferred markets, will lengthen patent protection by more 
than a decade to early 2042; 
•	 Phase 1 for ColoSTAT® update with U.S. based Contract Manufacturing Organisation (CMO) complete;
•	 Board’s Unanimous Recommendation supported in Extraordinary General Meeting (EGM);
•	 Maintained ISO 13485:2016 Certification;
•	 Appointment of Dr David Atkins as new Chief Executive Officer;
•	 Significant progress made on re-engineering ColoSTAT® assay into a simpler, higher quality multiplex antibody assay;
•	 Update of clinical strategy to include the indication of triage for patients symptomatic for bowel disease and with 
higher-than-average risk of colon cancer; and
•	 Significant upgrade of quality systems with migration to eQMS and strengthening of team to ensure consistent 
quality.
Significant Changes in the State of Affairs
During the year the Company issued:
•	 27,454,161 shares at 10 cents each from a rights issue and a subsequent shortfall placement, raising $2,745,416; and
•	 1,350,000 shares at 20 cents each from the exercise of options raising $270,000.
There were no other significant changes in the state of affairs of the consolidated entity during the financial year.
Future Developments
The Directors do not foresee any unusual future event that may significantly negatively impact the Group’s operations, 
results or state of affairs. Rhythm’s business model of developing diagnostic products for global markets will always 
bear some risk given the nature of technological development, competitors entering the market, changes in global 
healthcare, reliance on commercial partners and our ability to access capital to sustain operations. We cannot guarantee 
that Rhythm’s technology will be widely adopted. Moreover, the global Healthcare industry is an ever-evolving landscape 
where changes may impact our business opportunities.
Internal Risks:
Most risks associated with personnel are limited due to the use of external consultants and outsourced agencies. Our 
people risks were inherently our largest obstacle in the 2024 financial year which we have overcome with the training 
and diversification of knowledge. Cash Flow is identified as a potential risk despite the minimisation with the R&D grant 
expected. The management and Board have identified that Cash Flow will not be an impediment to the growth of the 
company.
The financial statements as at 30 June 2024 have been prepared on a going concern basis for the following reasons:
•	 as at 30 June 2024, the consolidated entity had a cash position of $709,496;
•	 a research and development refund for FY24, based on expenditure incurred, is expected to be received In full by 
November 2024. A secured loan obtained for $1,150,000 In August 2024 has provided early access to this forecast 
research and development refund. A resubmitted research and development claim for FY23 for overseas activities is 
also expected to be lodged in the near term;
•	 activities are focused on commercialising ColoSTAT® in various geographies;
•	 the Company has the potential to raise additional capital from investors and debt funding from financiers: The 
Directors are confident in the Company's ability to raise additional capital based on the Company's successful track 
record in doing so. Management has commenced activities in preparation for additional funding including initial 
meetings with third parties;
•	 the consolidated entity is still in the early stages of operations and is able to scale back activity if required for cashflow 
management purposes; and
11

•	 the forecast cash flows for the consolidated entity indicate that based on current cash on hand and expected inflows 
from research and development refunds and additional capital to be raised from investors, the consolidated entity is 
expected to maintain a positive cash position for at least the period of 12 months from the date the Directors approve 
the annual financial statements.
Whilst the Directors are confident in the consolidated entity's ability to continue as a going concern, in the event that 
cash flow forecasts are adversely impacted, and cash inflows described above do not eventuate as planned, there is a 
material uncertainty as to whether the consolidated entity will be able to execute alternative funding arrangements.
External Risks:
The major external risks are supply chain of raw materials and global demand.  With the current suppliers of raw materials and 
the proprietary recipe / algorithm, the raw material supply is adequate to ensure material supply to current and future target 
markets. It is anticipated that Rhythm will expand its CMO (Contract Manufacturers) globally.
Dividends
No dividends were paid or declared since the start of the financial year. No recommendation for payment has been made.
Directors and Company Secretaries
Names, qualifications and experience 
Name
Otto Buttula
Title
Non-Executive Chairman
Experience and expertise
Mr Buttula has had extensive experience and success in investment research, funds 
management, information and biotechnologies and has held directorships in a 
number of public companies. Mr Buttula’s executive experience includes co-founder 
and CEO and Managing Director of IWL Ltd, an online financial services company 
that listed on the ASX in 1999. The company grew from a market capitalisation of $48 
million at listing before a takeover in 2007 by Commonwealth Bank of Australia Ltd 
for $373 million. Mr Buttula also founded and was Managing Director of Investors 
Mutual, prior to which he was a co-founder and director of Lonsdale Securities Ltd.
Following his completion of executive duties, Mr Buttula was Non-Executive 
Chairman of platform and stockbroking provider Investorfirst Ltd and led the 
acquisition of HUB24 Ltd (ASX: HUB). More recently, he served on the Board as 
a non-executive director and Head of Audit and Risk at Imugene Ltd (ASX: IMU) 
between 2014 and 2016.
Former directorships
HITIQ Limited (resigned 27 November 2023)
OncoSil Medical Limited (resigned 31 August 2023)
Interests in shares
36,384,575 fully paid ordinary shares
Interests in options
5,425,001 Options/500,000 ESOP Options (expired 31 July 2024)
Name
Dr Trevor Lockett
Title
Non-Executive Director
Experience and expertise
A molecular biologist by trade, Trevor Lockett received his PhD in biochemistry from 
the University of Adelaide and postdoctoral experience at the Rockefeller University 
in New York. With over 30 years of research experience, predominantly at the CSIRO, 
Trevor has led large, multidisciplinary research efforts in the areas of prostate cancer 
gene therapy, colorectal cancer prevention and the promotion of gastrointestinal 
health. In his role as Theme Leader, Colorectal Cancer and Gut Health, Trevor 
oversaw the research efforts leading to the technology that is to become ColoSTAT™.
Interests in shares
1,678,300 fully paid ordinary shares
Interests in options
193,650 Options/125,000 ESOP Options (expired 31 July 2024)
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
12
DIRECTORS' REPORT

Name
Lou Panaccio
Title
Non-Executive Director
Experience and expertise
A chartered accountant with extensive management experience in business and 
healthcare services. Lou is currently on the boards of ASX listed companies Sonic 
Healthcare Limited and Avita Medical, Inc. Lou is also on the board of Unison 
Housing Ltd.  Lou has more than twenty years’ experience as a board member of 
both public and private, for profit and not for profit companies. Previously, Lou 
was the CEO of Melbourne Pathology and Monash IVF, and executive Chairman 
of Health Networks Australia.
Other current directorships
Sonic Healthcare Limited
Avita Medical, Inc.
Adherium Limited
Former directorships (last 3 years)
Nil
Interests in shares
1,079,000 fully paid ordinary shares
Interests in options
124,500 Options /37,500 ESOP Options (expired 31 July 2024)
Name
Ms Susan MacLeman 
Title
Non-Executive Independent Deputy Chair
Experience and expertise
Susan has more than 30 years’ experience as a pharmaceutical, biotechnology 
and medical technology executive having held senior roles in corporate, medical, 
commercial and business development at Schering-Plough Corporation (now 
Merck), Amgen, Bristol-Myers Squibb and Mesoblast. Susan has also served as 
CEO and a Board member of several ASX, AIM and NASDAQ listed companies 
in the Healthtech sector. Susan is a Non-Executive Director of Viral Vector 
Manufacturing Facility Pty Ltd, HOS Ltd T/A Smartways Logistics, Health 
Translation Group Ltd, Planet Innovation Holdings Ltd, ATSE and OMICO 
(Australian Genomic Cancer Medicines Ltd). Susan is also a member of the 
NSW Innovation and Productivity Council, Fellow of the Australian Academy of 
Technology and Engineering (ATSE) and Fellow/Graduate of Australian Institute 
of Company Directors (AICD). Susan is also appointed to several academic 
and government advisory boards. Susan brings a unique set of experiences in 
technology commercialisation, strategic planning, capital markets and fund 
raising, M&A and alliance management. Her broad commercial and technical 
experience is underpinned by a Bachelor of Pharmacy from the University of 
Queensland, a Master of Laws from Deakin University and a Master of Marketing 
from Melbourne Business School.
Interests in shares
Nil
Interests in options
200,000 ESOP Options
Name
Dr Rachel David
Title
Former Non-Executive Director (resigned 28 December 2023)
Experience and expertise
Rachel is an experienced senior health and financial services sector executive 
who holds a Bachelor of Medicine, Bachelor of Surgery (MBBS), Master of 
Business Administration (MBA) and is a graduate of the Australian Institute of 
Company Directors. Rachel is currently the Chief Executive Officer (CEO) of 
Private Healthcare Australia (PHA). Rachel's career has spanned over 25 years 
during which she has delivered significant value by promoting policy change to 
address the significant economic problems and market failures in healthcare, 
particularly relating to evidence-based practice and access to new technologies. 
Prior roles include Senior Director Government Affairs, Policy and Market Access 
for Johnson & Johnson, senior roles within McKinsey, CSL and Pfizer (formerly 
Wyeth). Further, Dr David has held direct Government roles within the Office of 
the Federal Minister for Health and Ageing.
13

'Other current directorships' quoted above are current directorships for listed entities only and excludes directorships of 
all other types of entities, unless otherwise stated.
'Former directorships (last 3 years)' quoted above are directorships held in the last 3 years for listed entities only and 
excludes directorships of all other types of entities, unless otherwise stated.
Company Secretaries
Andrea Steele (appointed 25 February 2022) has a Bachelor of Laws (LLB), a Master of Laws (LLM), a Master of Legal 
Practice and a Bachelor of Commerce (Accounting/Finance). Her professional career spans over 23 years and includes 
management consultancy, corporate strategy, company secretary and general counsel positions throughout Europe and 
Australia. Currently Ms Steele is a Principal Consultant at ENRG Consulting.
James Barrie’s (appointed 1 January 2024) experience includes governance, share registry, employee equity plans, 
investor relations, M&A, Treasury operations, capital management initiatives, financial accounting and reporting, 
business development, forecasting and budgeting and project management. In 2017 James established Fernville Group 
to provide solutions to unlisted and small-cap listed companies (ASX/NSX). Services include Non-Executive Director, 
Resident Director (for overseas subsidiary companies), outsourced Company Secretarial and CFO, virtual/hybrid AGMs, 
helping companies get "IPO ready" and ongoing business support post-listing. Prior to establishing Fernville, James held 
a range of senior executive positions in ASX20, ASX100, microcap, private and start-up organisations across industries 
including resources, pharmaceuticals, retail, technology, professional services and not-for-profit.
Paul Smith (appointed 17 October 2022, resigned 15 November 2023).
The Remuneration Report, which forms part of the Directors’ report, sets out information about the remuneration of the 
Company’s Directors and its Key Management Personnel for the financial year ended 30 June 2024. 
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
14
DIRECTORS' REPORT

Directors’ Report – Remuneration Report (Audited)
Names and positions held by Directors and Key Management Personnel at any time during the financial year were:
Name
Position
Date Appointed to Position
Mr Otto Buttula
Non-Executive Chairman
28 October 2019 (Executive Chairman from 1 December 
2021 to 31 May 2024)
Dr Trevor Lockett
Non-Executive Director
1 June 2017 (previously Technical Director until 15 
December 2023)
Mr Louis (Lou) Panaccio
Non-Executive Director
1 August 2017
Ms Susan MacLeman
Non-Executive Director
31 January 2023
Dr Rachel David
Non-Executive Director
15 December 2021 (resigned 28 December 2023)
Dr David Atkins
Chief Executive Officer 
13 May 2024
Mr Paul Smith
CFO & Company Secretary
17 October 2022 (resigned 15 November 2023)
Mr Guy Carisbrooke
Financial Controller
21 September 2023 (Key Management Personnel member 
from 16 November 2023)

Directors’ and Key Management Personnel Interests (received and acquired) in Shares and Options
Directors’ and Key Management Personnel’s interests in the ordinary shares and options as at the date of this report are 
detailed below:
Name
Position
Number of 
Ordinary Shares
Number  of
 Options
Number of 
Loan Funded Shares
Mr Otto Buttula
Non-Executive Chairman
36,384,575
5,425,001
-
Dr Trevor Lockett
Non-Executive Director
1,678,300
193,650
-
Mr Louis (Lou) Panaccio
Non-Executive Director
1,079,000
124,500
-
Ms Susan MacLeman
Non-Executive Director
-
200,000
-
Dr David Atkins
Chief Executive Officer 
-
4,000,000
4,000,000
39,141,875
9,943,151
 4,000,000
Remuneration Policy
The aim of the Company’s remuneration policy is to align the interests of directors and employees with those of 
shareholders. To do this Rhythm sets remuneration levels that attract and retain highly skilled and experienced directors 
and employees; and motivates and rewards performance that advances the Company’s strategic goals. 
Remuneration Structure
The remuneration of Key Management Personnel and employees is structured in two parts:
•	 Fixed Remuneration, comprising: base salary, superannuation and other benefits in lieu of salary; and
•	 Variable Remuneration, may include: a short-term incentive bonus (cash) and a long-term incentive in the form of 
options under the ESOP or loan funded shares.
The Company aims to set the level of fixed remuneration at market levels for comparable jobs, in similarly structured and 
sized companies in the industry in which the Company operates. No advice from a remuneration consultant was sought 
during the financial year.
Short-Term Incentive Plan (STIP)
The short-term incentive plan provides an incentive to employees to achieve an annual cash bonus on the achievement 
of corporate goals set at the beginning of each calendar year. These corporate goals are clearly defined, drive shareholder 
value and can be objectively measured. The percentage of an employee’s base salary that can be earned through the 
Short-Term Incentive Plan (STIP) is set by the Board for management personnel. At the end of the calendar year the 
Board assesses the level of achievement of these corporate goals. Payments made pursuant to the STIP are at the 
discretion of the Board. 
15

Long-Term Incentive Plan (LTIP)
The purpose of the long-term incentive plan is to align the interests of directors, management personnel and employees 
with those of the shareholders and provide reward for sustained achievement of the Group’s strategic objectives. Rhythm’s 
long-term incentive plan is implemented through the Employee Share Option Plan (ESOP) or loan funded shares. 
Options
During the 2024 year, 4,200,000 (2023: 10,950,000) Options were issued to management personnel and employees. 
The fair value of employee share options was $132,000 (2023: $5,812,500). $1,067,744 was reversed in the current financial 
year (2023: $3,003,935 expensed) for options issued in the current and previous years. In addition, $19,726 was expensed 
in the current financial year (2023: $nil) for loan funded shares. The options were issued for nil consideration and granted 
in accordance with performance guidelines established by the Board.
The following ESOP Share Options arrangements existed at 30 June 2024:
Number 
of Options
Exercise 
Price ($)
Grant Date
Vesting Period
Vesting Date
Expiry Date 
Holder
Fair Value per Option 
at Grant Date
212,500
$1.80
26.7.2021
Various (i)
Various (i)
31.7.2024
Employees
$0.45
1,450,000
$1.80
24.11.2021
Various (i)
Various (i)
31.7.2024
Directors 
$1.02
3,000,000
$1.80
31.12.2022
Various (i)
Various (i)
31.12.2025
Employees
$0.53
200,000
$1.80
10.10.2023
Various (i)
Various (i)
30.11.2025
S MacLeman
$0.06
2,000,000
$0.20
13.05.2024
Employment
13.05.2025
13.05.2026
D Atkins
$0.02
1,000,000
$0.30
13.05.2024
Employment 
13.05.2025 
31.03.2028
D Atkins
$0.04
1,000,000
$0.30
13.05.2024
Employment 
13.05.2026
31.03.2028
D Atkins
$0.04
8,862,500
Total ESOP Options
(i) There are various performance and or service vesting conditions related to these options not yet achieved. Refer to Note 17 for details on vesting conditions. 
These options include amounts outstanding at 30 June 2024 that lapsed past balance date.
All options granted are in respect of ordinary shares in Rhythm Biosciences Limited and confer a right of one ordinary share for each option held.
For factors that determine the fair value of options granted during the year refer to Note 17 to the financial statements.
Movement in the number of Share Options on issue
2024
2024
2023
2023
Number 
of Options
Weighted Average 
Exercise Price (cents)
Number 
of Options
Weighted Average 
Exercise Price (cents)
Opening balance
11,920,000
156.78
14,232,500
97.65
Voluntarily Forfeited / Lapsed
(5,907,500)
170.18
(9,687,500)
180.00
Granted
4,200,000
32.38
10,950,000
180.00
Exercised
(1,350,000)
20.00
(3,575,000)
20.00
Outstanding at year-end
8,862,500
110.04
11,920,000
156.78
Exercisable at year-end
1,640,625
180.00
4,891,250
123.30
Loan Funded Shares
During the 2024 year, Dr Atkins remuneration also includes awarded 'signing on' incentives for 4,000,000 Loan Funded 
Shares at $0.10 each (4 year non-recourse loan at 0% interest rate). The fair value of loan funded shares was $200,000.  
$19,726 was expensed in the current financial year (2023: $nil). The loan funded shares were issued for nil consideration 
and granted in accordance with performance guidelines established by the Board.
The following ESOP Loan Funded Share (LFS) arrangements existed at 30 June 2024:
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
16
DIRECTORS' REPORT

Number 
Issue
Price ($)
Grant Date
Vesting Period
Vesting Date
Expiry Date 
Holder
Fair Value    
per LFS at Grant 
Date
2,000,000
$0.10
13.5.2024
Employment
12.5.2025
12.5.2028
Dr Atkins
$0.05
2,000,000
$0.10
13.5.2024
Employment
12.5.2026
12.5.2028
Dr Atkins
$0.05
4,000,000
Total Loan Funded Shares
Non-Executive Director Remuneration
The Board considers the level of remuneration necessary to attract and retain Directors with the skills and experience 
required by the Company at its stage of development. Non-executive Directors fees are paid within an aggregate limit 
which is approved by the shareholders from time to time. No retirement payments are made to Non-executive Directors. 
Non-executive Directors’ fees were set at $52,500 per annum inclusive of superannuation. The Company entered 
into an executive services agreement effective 1 July 2022 for Mr Otto Buttula to receive an annual salary of $165,000 
(exclusive of superannuation). Effective 31 May 2024, Mr Buttula reverted to the role of Non-Executive Chairman on 
an annual salary of $105,000 (exclusive of superannuation).  Ms MacLeman receives a salary of $82,500 (inclusive of 
superannuation) per annum for her role as Deputy Chairman. 200,000 Options exercisable at $1.80 on or before 30 
November 2025 were issued to Ms MacLeman under the ESOP during the 2024 financial year. The Company entered 
into a revised consulting services agreement effective 1 July 2022 for Dr Trevor Lockett to receive an annual salary of 
$159,500 (inclusive of superannuation). Dr Lockett ceased his executive role on 15 December 2023 and continues as a 
Non-Executive Director.
Key Management Personnel Remuneration 
Key Terms of the CEO’s employment contract 
The Company entered into an executive services agreement effective 13 May 2024 for Dr David Atkins as Chief Executive 
Officer (CEO).
Dr Atkins annual remuneration consists of a fixed base remuneration of $350,000 (exclusive of superannuation) per 
annum. In addition to his base, he is eligible to participate in: 
(i) 	
up to 30% of that fixed base remuneration as a short-term incentive; and 
(ii) 	
up to 20% of that fixed base remuneration as a long-term incentive - as described below.
Execution Equity Incentive (EEI)
Dr Atkins remuneration also includes awarded 'signing on' incentives:
(i) 	
4,000,000 Loan Funded Shares at $0.10 (4 year non-recourse loan at 0% interest rate);
(ii) 	
2,000,000 Options, exercisable at $0.20 (unlisted, expiry of 31 March 2026); and
(iii) 	
2,000,000 Options, exercisable at $0.30 (unlisted, expiry of 31 March 2026 and 31 March 2028).
Short-term incentive (STI)
Dr Atkins is entitled in addition to his fixed income (FI) to a target short-term incentive with a maximum opportunity 
capped at 30% of FI. Payment of any STI will be subject to the financial and non-financial performance of the Group, Dr 
Atkins performance against performance targets and priorities set by the Board in consultation with Dr Atkins, the rules 
of the short-term incentive plan and relevant market information.
Short-term incentive awards are treated as follows:
(i) 	
50% will be paid in cash; and
(ii)	
50% will be deferred for two years in equity (on the terms of the Company's Omnibus Employee Incentive Plan).
Dividends, if any, will be paid on short-term equity (issued shares) incentives.
Unless the Board determines otherwise, Dr Atkins will forfeit any deferred short-term incentive if his employment ceases 
due to death, retirement, hardship, redundancy or other reason determined by the Board from time to time.
17

Long-term incentive (LTI)
Subject to any approval Rhythm considers necessary or appropriate, Dr Atkins will be entitled to participate in the 
Rhythm's Omnibus Employee Inventive Plan a long-term incentive scheme in accordance with the rules of the scheme 
and any applicable Rhythm policy. Dr Atkins will be entitled to an annual long-term incentive grant up to 20% of his FI. 
This is a four-year performance period. The number of equity incentive rights (66.67% Loan Funded Shares and 33.33% 
3-year unlisted options) granted will be determined using Rhythm’s share price (face value). 
Dividends, if any, will be paid on long-term equity (issued shares) incentives.
If at any time approval of Dr Atkins participation in the Rhythm's Omnibus Employee Inventive Plan is sought but not 
obtained, he will be entitled to receive a cash payment equivalent in value to the long-term incentive that would have 
been granted had shareholder approval been obtained, subject to the same performance hurdles and timing for vesting 
(payment).
Dr Atkins will forfeit any cash long-term incentive if his employment is terminated by his resignation (unless approved by 
Rhythm or due to his death or illness), due to his misconduct, or if Rhythm determines that such action is necessary to 
protect the financial soundness of Rhythm or where adverse outcomes have arisen that reduce the original assessment 
of the performance generating the provision of the benefit.
If Dr Atkins employment is terminated by the provision of notice by Rhythm or by the provision of notice by Dr Atkins with 
Rhythm approval or due to his death or illness, at Rhythm’s discretion he will forfeit either all or a pro rata portion of the cash 
long-term incentive taking into account his employment period as a portion of the performance period for the incentive.
Clawback Policy
Rhythm retains discretion to clawback some or all of any short or long term incentive awarded to Dr Atkins (if not already paid 
or vested) if Rhythm considers such award(s) would be an inappropriate benefit pursuant to the Rhythm Clawback Policy. 
Termination
Rhythm may terminate Dr Atkins employment at any time on three months’ notice or payment in lieu of notice. Dr Atkins 
may terminate his employment with Rhythm at any time on three months’ notice or, at Rhythm’s election, payment in lieu 
of notice. Dr Atkins employment may also be summarily terminated (without notice) by Rhythm in circumstances of his 
misconduct or long- term illness.
Restrictive covenant
Dr Atkins will be restrained for up to six months after termination of his employment with Rhythm from being engaged in 
competition with Rhythm, and from soliciting Rhythm employees or persuading people who do business with Rhythm to 
cease or reduce their business with Rhythm.
Key Terms of the former CFO’s employment contract 
The Company entered into an executive services agreement effective 17 October 2022 for Mr Paul Smith as Chief 
Financial Officer (CFO) and Company Secretary to receive an annual salary of $265,000 (exclusive of superannuation). 
The Company also issued Mr Smith 2,000,000 unlisted Options exercisable at $1.80 on or before 31 December 2025. 
Refer to Note 17 for details on Options vesting conditions. Mr Smith was also entitled to receive short-term incentives 
dependent upon performance, as assessed against key performance indicators. Mr Smith resigned effective 15 
November 2023.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
18
DIRECTORS' REPORT

Details of the remuneration of Directors and Key Management Personnel for the 2024 financial year are provided below:
Short-term Benefits
 Long-term Benefits
% 
Performance 
Based
Cash 
salary 
and fees
($)
Termination 
benefit
 ($)
Annual 
Leave 
Provision
($)
Long 
Service 
Leave 
Provision 
($)
Post-employment
Superannuation
($)
Equity-based 
compensation
Shares
and Options 
($)
Total 
($)
Executive Directors
O Buttula
160,000
-
-
-
17,600
191,510
369,110
51.9
T Lockett
91,475
-
-
-
10,062
47,878
149,415
32.0
Non-Executive Directors
S MacLeman
74,217
-
-
-
8,164
5,359
87,740
6.1
L Panaccio
47,297
-
-
-
5,203
14,363
66,863
21.5
R David (i)
23,649
-
-
-
2,601
(26,421)
(171)
-
Executives 
D Atkins (ii)
49,359
-
3,706
-
5,429
32,877
91,371
36.0
P Smith (iii)
99,545
-
(14,480)
-
10,950
(260,334)
(164,319)
-
G Carisbrooke (iv)
125,135
-
4,272
-
13,765
-
143,172
-
Total
670,677
(6,502)
73,774
5,232
743,181
(i) Resigned 28 December 2023.
(ii) Appointed 13 May 2024. 
(iii) Resigned 15 November 2023.
(iv) Employed from 21 September 2023 (Key Management Personnel member from 16 November 2023).
(v) Factors that determine the fair value of equity based compensation are set out in Note 17 to the financial statements. 
Details of the remuneration of Directors and Key Management Personnel for the 2023 financial year are provided below:
Short-term Benefits
 Long-term Benefits
% 
Performance 
Based
Cash 
salary 
and fees
($)
Termination 
benefit
 ($)
Annual 
Leave 
Provision
($)
Long 
Service 
Leave 
Provision 
($)
Post-employment
Superannuation
($)
Equity-based 
compensation
Shares
and Options 
($)
Total 
($)
Executive Directors
O Buttula
165,000
-
-
-
17,325
191,510
373,835
51.2
T Lockett
144,344
-
-
-
15,156
47,878
207,378
23.1
G Gilbert (iv)
284,936
96,688
6,179
(16,443)
35,370
397,500
804,230
49.4
Non-Executive Directors
L Panaccio
47,511
-
-
-
4,989
14,363
66,863
21.5
E Vom (i)
18,854
-
-
-
1,980
-
20,834
-
R David
47,511
-
-
-
4,989
48,546
101,046
48.0
S MacLeman (ii)
19,796
-
-
-
2,079
-
21,875
-
Executives
P Smith (iii)
188,234
-
14,480
-
19,765
525,334
747,813
70.2
Total
916,186
96,688
20,659
(16,443)
101,653
1,225,131
2,343,874
(i) Resigned 29 November 2022.
(ii) Appointed 31 January 2023. 
(iii) Appointed 17 October 2022. 
(iv) Resigned 21 April 2023. During the year the amount paid for superannuation included 10.5% on a portion of annual leave entitlement taken as a cash payment.
(v) Factors that determine the fair value of equity based compensation are set out in Note 17 to the financial statements. 
19

Share-Based Payments
No shares were issued to employees during the current or prior year. 
There were 1,350,000 (2023: 3,575,000) ordinary shares issued during the financial year from the exercise of employee 
share options.
Dr Atkins remuneration included 4,000,000 Loan Funded Shares at $0.10 (4 year non-recourse loan at 0% interest rate).
Options Holdings
The number of options and loan funded shares over ordinary shares in the Company held during and at the end of the 
financial year by each Director and Key Management Personnel, including related parties, are set out below (refer also to 
Note 17 for further details): 
Balance at 
Beginning 
of Year
Granted 
During Year
Exercised 
During Year 
Lapsed
Acquired
Balance at 
End of Year
Vested and 
Exercisable 
at End of Year
Unvested at 
End of Year
T Lockett
1,377,000
-
(1,125,000)
-
193,650
445,650
320,650
125,000
O Buttula
1,342,500
-
-
-
4,925,001
6,267,501
5,767,501
500,000
S MacLeman
-
200,000
-
-
-
200,000
50,000
150,000
R David
150,000
-
-
(150,000)
-
-
-
-
L Panaccio
85,000
-
-
-
124,500
209,500
172,000
37,500
D Atkins
4,000,000
-
-
-
4,000,000
-
4,000,000
P Smith
2,000,000
-
-
(2,000,000)
-
-
-
Total
4,954,500
4,200,000
(1,125,000)
(2,150,000)
5,243,151
11,122,651
6,310,151
4,812,500
Shareholdings and Loan Funded Shares Holdings
The number of ordinary shares and loan funded shares in the Company held during and at the end of the 2024 financial 
year by each Director and Key Management Personnel of the Group, including related parties, are set out below.
Balance at 
Beginning 
of Year
Share-based 
Compensation
Acquired via 
Rights Issue
Upon 
Appointment/
Resignation
On-market 
and Other 
Transactions
Balance at 
End of Year
Directors
O Buttula
24,111,396
-
12,273,179
-
-
36,384,575
S MacLeman
-
-
-
-
-
-
L Panaccio
830,000
-
249,000
-
-
1,079,000
R David
-
-
-
-
-
-
T Lockett
166,000
-
1,512,300
-
-
1,678,300
D Atkins
-
-
-
-
-
-
D Atkins - Loan Funded Shares
-
4,000,000
-
-
-
4,000,000
P Smith
-
-
-
-
-
-
Total
25,107,396
4,000,000
14,034,479
-
-
43,141,875
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
20
DIRECTORS' REPORT

Additional Information
The earnings of the consolidated entity are summarised below:
Loss after income tax of $6,856,761 for the year ended 30 June 2024 (2023: $8,217,557).
The factors that are considered to affect total shareholders return ('TSR') are summarised below:
2024
2023
2022
2021
2020
Share price at the end of the financial year 
$0.06
$0.41
$1.15
$0.89
$0.07
Basic Loss per share (cents per share) for the year 
  3.00
  3.79
  4.19
  3.57
  3.99
Related Party Transactions
During the 2024 and 2023 financial years there were no transactions with related parties other than remuneration.
From time to time the Directors incur and are reimbursed for costs arising in fulfilling their duties, such as travel and 
accommodation charges.
This concludes the remuneration report, which has been audited.
Unissued Shares or Interests under Option
The company has issued 13,727,168 listed Options with an exercise price of $0.20 each expiring on 31 March 2026.
The following unlisted Unissued Shares or Interests under Option existed as at the date of this report:
Number of 
Options
Exercise
Price ($)
Grant 
Date
Vesting 
Conditions
Vesting 
Date
Expiry 
Date
Holder
200,000
$1.80
10.10.2023
Various
Various
30.11.2025
S MacLeman
2,000,000
$0.20
13.05.2024
Employment
13.05.2025
13.05.2026
D Atkins
1,000,000
$0.30
13.05.2024
Employment 
13.05.2025 
31.03.2028
D Atkins
1,000,000
$0.30
13.05.2024
Employment 
13.05.2026
31.03.2028
D Atkins
4,200,000
The following ESOP Loan Funded Share arrangements existed as at the date of this report::
Number
Issue
Price ($)
Grant 
Date
Vesting 
Conditions
Vesting 
Date
Expiry 
Date
Holder
2,000,000
$0.10
13.5.2024
Employment
12.5.2025
12.5.2028
Dr Atkins
2,000,000
$0.10
13.5.2024
Employment
12.5.2026
12.5.2028
Dr Atkins
4,000,000
Voting and comments made at the Company’s 2023 Annual General Meeting
At the 2023 Annual General Meeting the 2023 Remuneration Report was voted on by shareholders with 3.58% of votes 
against the resolution.
Environmental Issues
Rhythm’s operations are subject to certain environmental regulations under the laws of the Commonwealth and State. 
The Directors are not aware of any breaches during the period covered by this report. 
21

After Balance Date Events 
On 14 August 2024, the Company announced on the ASX it entered into a secured loan facility agreement (Loan) which 
will provide early access to $1,150,000 cash of its forecast ~$1,500,000 FY24 R&D Tax Incentive (RDTI Rebate) expected 
to be received in full by November 2024.
The Loan is secured by and repayable out of the FY24 RDTI Rebate and attracts a fixed 1.33% per month interest rate. It 
matures on 31 December 2024, however, can be extended by agreement between the lender and Rhythm. This Loan is 
intended to be used in a bridging period prior to receiving the FY24 RDTI Rebate, along with the amended FY23 RDTI 
rebate for overseas activities. 
There has been no other matters or circumstances which have arisen since 30 June 2024 that has significantly affected or 
may significantly affect:
•	 the operations, in financial years subsequent to 30 June 2024, of the consolidated entity; or
•	 the results of those operations; or 
•	 the state of affairs, in financial years subsequent to 30 June 2024, of the consolidated entity.
Proceedings on Behalf of the Company
No person has applied to the Court under section 237 of the Corporations Act 2001 for leave to bring proceedings on 
behalf of the Company, or to intervene in any proceedings to which the Company is a party for the purpose of taking 
responsibility on behalf of the Company for all or any part of those proceedings. 
Indemnity and insurance of officers
The Company has paid a premium for Directors’ and Officers’ Liability (Management Liability) Insurance. 
Under the Company’s constitution:
i.	 To the extent permitted by law and subject to the restrictions in sections 199A and 199B of the Corporations Act 2001, 
the Company indemnifies every person who is or has been an officer of the Company against any liability (other than 
for legal costs) incurred by that person as an officer of the Company.
ii.	 To the extent permitted by law and subject to the restrictions in sections 199A and 199B of the Corporations Act 2001, 
the Company indemnifies every person who is or has been an officer of the Company against reasonable legal costs 
incurred in defending an action for a liability incurred by that person as an officer of the Company.
The Company insures its Directors, Company Secretary, and executive officers under a Management Liability Insurance 
policy. Under the Company’s Management Liability Insurance Policy, the Company cannot release to any third party or 
otherwise publish details of the nature of the liabilities insured by the policy or the amount of the premium. Accordingly, 
the Company relies on section 300(9) of the Corporations Act 2001 to exempt it from the requirement to disclose the 
nature of the liability insured against and the premium amount of the relevant policy. 
Indemnity and insurance of auditor
The Company has not, during or since the end of the financial year, indemnified or agreed to indemnify the auditor of the 
Company or any related entity against a liability incurred by the auditor. During the financial year, the Company has not 
paid a premium in respect of a contract to insure the auditor of the Company or any related entity.
Auditor’s Independence Declaration 
A copy of the auditor’s independence declaration as required under s307C of the Corporations Act 2001 is set out on 
page 24.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
22
DIRECTORS' REPORT

Non-Audit Services
BDO Audit Pty Ltd were paid $13,100 (2023: $25,280) for non-audit services during the 2024 financial year. Non-audit 
services related to tax compliance services. 
The directors are satisfied that the provision of non-audit services during the financial year, by the auditor, is compatible 
with the general standard of independence for auditors imposed by the Corporations Act 2001 for the following reasons:
•	 ●all non-audit services have been reviewed and approved to ensure that they do not impact the integrity and 
objectivity of the auditor; and
•	 ●none of the services undermine the general principles relating to auditor independence as set out in APES 110 Code of 
Ethics for Professional Accountants (including Independence Standards) issued by the Accounting Professional and 
Ethical Standards Board, including reviewing, or auditing the auditor's own work, acting in a management or decision-
making capacity for the Company, acting as advocate for the Company or jointly sharing economic risks and rewards.
There are no officers of the company who are former directors of BDO Audit Pty Ltd.
This report is made in accordance with a resolution of the Directors. 
Otto Buttula
Non-Executive Chairman
Melbourne, Australia
Dated this 30th day of August 2024
23

Collins Square, Tower Four 
Level 18, 727 Collins Street 
Melbourne VIC 3008 
GPO Box 5099 Melbourne VIC 3001 
Australia 
Tel: +61 3 9603 1700 
Fax: +61 3 9602 3870 
www.bdo.com.au 
BDO Audit Pty Ltd ABN 33 134 022 870 is a member of a national association of independent entities which are all members of BDO Australia 
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International Ltd, a UK company limited by guarantee, and form part of the international BDO network of independent member firms. 
Liability limited by a scheme approved under Professional Standards Legislation. 
DECLARATION OF INDEPENDENCE BY TONY BATSAKIS TO THE DIRECTORS OF RHYTHM BIOSCIENCES 
LIMITED 
As lead auditor of Rhythm Biosciences Limited for the year ended 30 June 2024, I declare that, to the 
best of my knowledge and belief, there have been: 
1.
No contraventions of the auditor independence requirements of the Corporations Act 2001 in
relation to the audit; and
2.
No contraventions of any applicable code of professional conduct in relation to the audit.
This declaration is in respect of Rhythm Biosciences Limited and the entities it controlled during the 
period. 
Tony Batsakis 
Director 
BDO Audit Pty Ltd 
Melbourne, 30 August 2024 
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
24
AUDITOR'S INDEPENDENCE DECLARATION

The financial statements should be read in conjunction with the accompanying notes.
Consolidated Statement of Profit or Loss and Other Comprehensive Income  
Notes
2024 ($)
2023 ($)
Income
Income
3
1,742,426
3,324,112
Expenses
Employment related costs
4
(1,590,179)
(6,298,904)
Office and compliance costs
(1,218,452)
(992,663)
Research and development costs
(2,345,560)
(3,647,711)
Marketing and investor relations
(115,498)
(175,558)
Occupancy costs
(41,362)
(32,052)
Travel and meetings
(38,817)
(198,847)
Depreciation - PPE
10
(74,035)
(64,508)
Depreciation - ROU
(88,654)
(88,898)
Amortisation of intangibles
9
(35,971)
(35,971)
Inventory impairment expense
8
(3,047,516)
-
Finance expense
(3,143)
(6,557)
Loss Before Income Tax
(6,856,761)
(8,217,557)
Income tax expense
5
-
-
Loss After Tax
(6,856,761)
(8,217,557)
Other comprehensive income
-
-
Total Comprehensive Loss for the Year
(6,856,761)
(8,217,557)
Loss Per Share
Basic loss per share (cents per share)
6
(3.00)
(3.79)
Diluted loss per share (cents per share)
6
(3.00)
(3.79)
25
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Consolidated Statement of Financial Position
Notes
2024 ($)
2023 ($)
Current Assets
Cash and cash equivalents
15
709,496
4,124,181
Trade and other receivables
7
37,199
65,513
Other financial assets – term deposit
45,000
45,000
Prepayments
94,973
117,569
Inventories – raw materials
8
-
2,766,682
Total Current Assets
886,668
7,118,945
Non-Current Assets
Intangible assets
9
354,102
390,073
Right-of-use assets
164,779
81,490
Property, plant and equipment
10
113,159
104,913
Total Non-Current Assets
632,040
576,476
Total Assets
1,518,708
7,695,421
Current Liabilities
Trade and other payables
11
459,709
1,522,843
Provisions
12
23,782
158,139
Lease liabilities
78,351
84,606
Total Current Liabilities
561,842
1,765,588
Non-Current Liabilities
Provisions
12
4,229
55,382
Lease liabilities 
85,471
-
Total Non-Current Liabilities
89,700
55,382
Total Liabilities
651,542
1,820,970
Net Assets
867,166
5,874,451
Equity
Issued capital
13
34,448,096
31,550,602
Reserves
14
5,093,243
6,141,261
Accumulated losses
(38,674,173)
(31,817,412)
Total Equity
867,166
5,874,451
The financial statements should be read in conjunction with the accompanying notes.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
26
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

The financial statements should be read in conjunction with the accompanying notes.
Consolidated Statement of Changes in Equity
Issued Capital 
($)
Reserves 
($)
Accumulated 
Losses ($)
Total 
($)
Balance at 1 July 2022
27,834,579
3,137,326
(23,599,855)
7,372,050
Loss attributable to members
-
-
(8,217,557)
(8,217,557)
Total comprehensive income/(loss) for the year
-
-
(8,217,557)
(8,217,557)
Transactions with owners in their capacity as owners:
Issued capital
3,740,240
-
-
3,740,240
Capital raising costs
(24,217)
-
-
(24,217)
Share-based payments expense (Note 17)
-
3,003,935
-
3,003,935
Total transactions with owners of the Company
3,716,023
3,003,935
-
6,719,958
Balance at 30 June 2023
31,550,602
6,141,261
(31,817,412)
5,874,451
Balance at 1 July 2023
31,550,602
6,141,261
(31,817,412)
5,874,451
Loss attributable to members
-
-
(6,856,761)
(6,856,761)
Total comprehensive income/(loss) for the year
-
-
(6,856,761)
(6,856,761)
Transactions with owners in their capacity as owners:
Issued capital
3,015,416
-
-
3,015,416
Capital raising costs
(117,922)
-
-
(117,922)
Share-based payments expense (Note 17)
-
(1,048,018)
-
(1,048,018)
Total transactions with owners of the Company
2,897,494
(1,048,018)
-
1,849,476
Balance at 30 June 2024
34,448,096
5,093,243
(38,674,173)
867,166
27

Consolidated Statement of Cash Flows
Notes
2024 ($)
2023 ($)
Cash Flow from Operating Activities
Interest received
52,282
228,379
Payments to suppliers and employees
(7,876,454)
(10,275,274)
Interest paid
(3,143)
(6,557)
Government grant
-
15,000
Other income
-
297
Research and development tax refund
1,690,144
3,080,545
Net Cash Used in Operating Activities
15
(6,137,171)
(6,957,610)
Cash Flow from Investing Activities
Purchase of property, plant and equipment
10
(82,281)
(99,122)
Net Cash Used In Investing Activities
(82,281)
(99,122)
Cash Flow from Financing Activities
Proceeds from issues of shares and options
3,015,416
3,740,240
Costs of capital raising
(117,922)
(24,217)
Repayment of lease liabilities
10
(92,727)
(85,534)
Net Cash From/(Used in) Financing Activities
2,804,767
3,630,489
Net Increase/(Decrease) in Cash Held
(3,414,685)
(3,426,243)
Cash and cash equivalents at beginning of financial year
4,124,181
7,550,424
Cash And Cash Equivalents at end of Financial Year
709,496
4,124,181
The financial statements should be read in conjunction with the accompanying notes.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
28
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Note 1: Material Accounting Policy Information
The consolidated financial statements and notes represent 
those of Rhythm Biosciences Limited and Controlled Entities 
(the ‘consolidated entity’ or ‘Group’). The separate financial 
statements of the parent entity, Rhythm Biosciences 
Limited ('the Company'), have not been presented within 
this financial report as permitted by amendments made to 
the Corporations Act 2001. The financial report covers the 
economic entities of Rhythm Biosciences Limited and its 
controlled entities as an economic entity for the year ended 
30 June 2024. Comparatives are disclosed for the year 
ended 30 June 2024.
The financial statements are presented in Australian 
dollars, which is the Group’s functional and presentation 
currency. The financial statements were authorised 
for issue on the date of the approval of the Directors' 
declaration by the Directors of the Company.
Statement of Compliance
These financial statements are general purpose financial 
statements which have been prepared in accordance 
with the Corporations Act 2001, Australian Accounting 
Standards and Interpretations, and comply with other 
requirements of the law. The financial statements 
comprise the consolidated financial statements of the 
Group. For the purposes of preparing the consolidated 
financial statements, the Company is a for-profit entity. 
Compliance with Australian Accounting Standards 
ensures that the financial statements and notes of the 
Company and the Group comply with International 
Financial Reporting Standards (‘IFRS’).
Basis of Preparation
Australian Accounting Standards set out accounting 
policies that the AASB has concluded would result 
in a financial report containing relevant and reliable 
information about transactions, events and conditions to 
which they apply. Material accounting policies adopted 
in the preparation of this financial report are presented 
below. They have been consistently applied unless 
otherwise stated.
The financial report has been prepared on an accruals 
basis and is based on historical costs.
Going Concern
The consolidated entity incurred an operating loss of 
$6,856,761 (2023: $8,217,557) and had cash outflows from 
operating activities of $6,137,171 (2023: $6,957,610) for the 
year ended 30 June 2024. The consolidated entity is in 
start-up phase and does not yet have an income stream. 
These conditions indicate a material uncertainty that may 
cast significant doubt about the consolidated entity’s 
ability to continue as a going concern.  
The financial statements have been prepared on a going 
concern basis, which contemplates the continuity of 
normal business activities and the realisation of assets 
and the settlement of liabilities in the normal course of 
business for the following reasons:
•	 as at 30 June 2024, the consolidated entity had a cash 
position of $709,496;
•	 a research and development refund for FY24, based 
on expenditure incurred, is expected to be received In 
full by November 2024. A secured loan obtained for 
$1,150,000 In August 2024 has provided early access 
to this forecast research and development refund. A 
resubmitted research and development claim for FY23 
for overseas activities is also expected to be lodged in 
the near term;
•	 activities are focused on commercialising ColoSTAT® in 
various geographies;
•	 the Company has the potential to raise additional 
capital from investors and debt funding from financiers: 
The Directors are confident in the Company's ability 
to raise additional capital based on the Company's 
successful track record in doing so. Management has 
commenced activities in preparation for additional 
funding including initial meetings with third parties;
•	 the consolidated entity is still in the early stages of 
operations and is able to scale back activity if required 
for cashflow management purposes; and
•	 the forecast cash flows for the consolidated entity 
indicate that based on current cash on hand and 
expected inflows from research and development 
refunds and additional capital to be raised from 
investors, the consolidated entity is expected to 
maintain a positive cash position for at least the period 
of 12 months from the date the Directors approve the 
annual financial statements.
Whilst the Directors are confident in the consolidated 
entity's ability to continue as a going concern, in the 
event that cash flow forecasts are adversely impacted, 
and cash inflows described above do not eventuate as 
planned, there is a material uncertainty as to whether the 
consolidated entity will be able to execute alternative 
funding arrangements to enable it to continue as a going 
concern beyond the 12 months from the date the Directors 
approve the annual financial statements.
Consequently, a material uncertainty exists as to whether 
the consolidated entity will continue as a going concern 
and it may therefore be required to realise its assets 
at amounts different to their carrying amounts in the 
29

consolidated statement of financial position, extinguish 
liabilities at amounts different to  those recorded In the 
consolidated statement of financial position and settle 
liabilities other than In the ordinary course of business.
Revenue Recognition
Interest income is recognised as it accrues, taking into 
account the effective yield on the financial asset.
Government stimulus and research and development tax 
refund income is recognised when there is reasonable 
assurance that the eligibility conditions are met and that 
the grants will be received.
Inventories
Raw materials, work in progress and finished goods are 
stated at the lower of cost and net realisable value on 
a 'weighted average' basis. Cost comprises of direct 
materials and delivery costs, direct labour, import 
duties and other taxes. Costs of purchased inventory 
are determined after deducting rebates and discounts 
received or receivable.
Stock in transit is stated at the lower of cost and net 
realisable value.  Cost comprises of purchase and delivery 
costs, net of rebates and discounts received or receivable.
Net realisable value is the estimated selling price in the ordinary 
course of business less the estimated costs of completion 
and the estimated costs necessary to make the sale.
Right-of-use assets
A right-of-use asset is recognised at the commencement 
date of a lease. The right-of-use asset is measured at cost, 
which comprises the initial amount of the lease liability, 
adjusted for, as applicable, any lease payments made at or 
before the commencement date net of any lease incentives 
received, any initial direct costs incurred, and, except where 
included in the cost of inventories, an estimate of costs 
expected to be incurred for dismantling and removing the 
underlying asset, and restoring the site or asset. 
Right-of-use assets are depreciated on a straight-line basis 
over the unexpired period of the lease or the estimated 
useful life of the asset, whichever is the shorter. Where the 
consolidated entity expects to obtain ownership of the 
leased asset at the end of the lease term, the depreciation 
is over its estimated useful life. Right-of use assets are 
subject to impairment or adjusted for any remeasurement 
of lease liabilities. 
At 30 June 2024, the Group leased office premises at 
Bio21 Institute, 30 Flemington Road, Parkville, Victoria 
with an expiry date of 31 May 2025 and has an option to 
renew for a further one year. The lease liability includes the 
extension option. The undiscounted payments due less 
than one year are $97,699 and between one to two years 
are $92,014. Non-cash additions to right-of-use assets in 2024 
were $171,943.
Property, Plant and Equipment
Each class of property, plant and equipment is carried at 
cost less, where applicable, any accumulated depreciation 
and impairment.
Plant & Equipment
The carrying amount of plant and equipment is reviewed 
annually by the Directors to ensure it is not in excess of the 
recoverable amount from these assets. The recoverable 
amount is assessed on the basis of the expected net cash 
flows that will be received from the asset's employment 
and subsequent disposal. The expected net cash 
flows have been discounted to their present values in 
determining recoverable amounts.
Subsequent costs are included in the asset’s carrying 
amount or recognised as a separate asset, as appropriate, 
only when it is probable that future economic benefits 
associated with the item will flow to the Group and the cost 
of the item can be measured reliably. All other repairs and 
maintenance are charged to the income statement during 
the financial period in which they are incurred. 
Depreciation
The depreciable amount of all fixed assets, including 
building and capitalised lease assets but excluding 
freehold land, is depreciated on a straight-line basis over 
their useful lives to the Group commencing from the time 
the asset is held ready for use. Items of property, plant and 
equipment, are depreciated over their estimated useful 
lives. The depreciation rates for each class of asset are:
Class of 
Non-Current Asset
Depreciation 
Rate
Estimated 
Useful Lives
Office Equipment
10%
10 years
Computer Equipment
33.3%
3 years
Laboratory Equipment
33.3%
3 years

The assets’ residual values and useful lives are reviewed, and 
adjusted if appropriate, at each end of reporting period. An 
asset’s carrying amount is written down immediately to its 
recoverable amount if the asset’s carrying amount is greater 
than its estimated recoverable amount.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
30
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Intangibles
Research and development
Expenditure during the research phase of a project 
is recognised as an expense when incurred. Product 
development costs are capitalised only when each of the 
following specific criteria has been satisfied:
i.	 Technical feasibility of completing development of the 
product and obtaining approval by regulatory authorities. 
ii.	  Ability to secure a commercial partner for the product.
iii.	  Availability of adequate technical, financial and other 
resources to complete development of the product, obtain 
regulatory approval and secure a commercial partner.
iv.	  Reliable measurement of expenditure attributable to 
the product during its development.
v.	 High probability of the product entering a major 
diagnostic market.
Capitalised development costs have a finite life and are 
amortised on a systematic basis over the period from when 
the product becomes available for use and ceases at the 
earlier of the date the asset is expected to exit the market 
or that the asset is classified as held for sale (or included 
in a disposal group that is classified as held for sale) in 
accordance with AASB 5.
Other intangible assets
Other intangible assets comprise licences and are stated at 
cost less accumulated amortisation and impairment losses.
Employee Entitlements
Short-term and long-term employee benefits
A liability is recognised for benefits accruing to employees 
for wages and salaries and annual leave in the year the 
related service is rendered. Liabilities recognised in 
respect of short-term employee benefits are measured at 
their nominal values using the remuneration rate expected 
to apply at the time of settlement. Liabilities recognised in 
respect of long-term employee benefits are measured as 
the present value of the estimated future cash outflows to 
be made by the Group in respect of services provided by 
employees up to reporting date. Contributions are made 
by the Group to employee superannuation funds and are 
charged as expenses when incurred
Share-based compensation
Equity-settled and cash-settled share-based 
compensation benefits are provided to employees. 
Equity-settled transactions are awards of shares, or 
options over shares including loan funded shares that 
meet the criteria of options over shares, including loan 
funded shares that meet the criteria of optoins over 
shares, that are provided to employees in exchange for 
the rendering of services. Cash-settled transactions are 
awards of cash for the exchange of services, where the 
amount of cash is determined by reference to the share 
price.
The cost of equity-settled transactions are measured 
at fair value on grant date. Fair value is independently 
determined using either the Binomial or Black-Scholes 
option pricing or models that takes into account the 
exercise price, the term of the option, the impact of 
dilution, the share price at grant date and expected price 
volatility of the underlying share, the expected dividend 
yield and the risk free interest rate for the term of the 
option, together with non-vesting conditions that do not 
determine whether the consolidated entity receives the 
services that entitle the employees to receive payment. No 
account is taken of any other vesting conditions.
The cost of equity-settled transactions are recognised as 
an expense with a corresponding increase in equity over 
the vesting period. The cumulative charge to profit or 
loss is calculated based on the grant date fair value of the 
award, the best estimate of the number of awards that are 
likely to vest and the expired portion of the vesting period. 
The amount recognised in profit or loss for the period is 
the cumulative amount calculated at each reporting date 
less amounts already recognised in previous periods.
The cost of cash-settled transactions is initially, and at each 
reporting date until vested, determined by applying either 
the Binomial or Black-Scholes option pricing model, taking 
into consideration the terms and conditions on which the 
award was granted. The cumulative charge to profit or loss 
until settlement of the liability is calculated as follows:
•	 ●during the vesting period, the liability at each reporting 
date is the fair value of the award at that date multiplied 
by the expired portion of the vesting period.
•	 ●from the end of the vesting period until settlement of 
the award, the liability is the full fair value of the liability 
at the reporting date.
All changes in the liability are recognised in profit or loss. 
The ultimate cost of cash-settled transactions is the cash 
paid to settle the liability.
Market conditions are taken into consideration in 
determining fair value. Therefore, any awards subject to 
market conditions are considered to vest irrespective 
of whether or not that market condition has been met, 
provided all other conditions are satisfied.
31

If equity-settled awards are modified, as a minimum 
an expense is recognised as if the modification has 
not been made. An additional expense is recognised, 
over the remaining vesting period, for any modification 
that increases the total fair value of the share-based 
compensation benefit as at the date of modification.
If the non-vesting condition is within the control of the 
consolidated entity or employee, the failure to satisfy 
the condition is treated as a cancellation. If the condition 
is not within the control of the consolidated entity or 
employee and is not satisfied during the vesting period, 
any remaining expense for the award is recognised over 
the remaining vesting period, unless the award is forfeited.
Issued Capital
Ordinary shares are classified as equity. Incremental costs 
directly attributable to the issue of new shares or options are 
shown in equity as a deduction, net of tax, from the proceeds.
Financial Instruments
Recognition
Financial instruments are initially measured at fair value on 
transaction date, plus or minus transaction costs directly 
attributable to the acquisition. Subsequent to initial 
recognition these instruments are measured as set out below. 
Financial assets  
Cash balances are recognised at amortised cost using the 
effective interest rate method. 
Financial liabilities 
Non-derivative financial liabilities are recognised at amortised 
cost, comprising original debt less principal payments and 
amortisation. Lease liabilities have been recorded adopting 
an Incremental borrowing rate of 15% (2023: 4.99%).
Impairment
An 'expected credit loss' ('ECL') model is used to recognise 
an allowance. Impairment is measured using a 12-month 
ECL method unless the credit risk on a financial instrument 
has increased significantly since initial recognition in which 
case the lifetime ECL method is adopted.
Critical Accounting Estimates and Judgments
The Directors evaluate estimates and judgments 
incorporated into the financial report based on historical 
knowledge and best available current information. 
Estimates assume a reasonable expectation of future 
events and are based on current trends and economic 
data, obtained both externally and within the Group.
Key Estimates
Share-based payments
Rhythm operates an Employee Share Option Plan 
(ESOP). The non-cash expense of issuing these options 
is calculated using a Black-Scholes option pricing model. 
This model requires the input of a number of variables 
including an estimate of future volatility and a risk-free 
interest rate. The probability of meeting any vesting 
conditions is also required to be estimated. Refer to Note 
17 to the financial statements. 
Research and Development Tax Refund Income
Research and development tax refund income Is 
recognised when there Is reasonable assurance that 
the eligibility conditions are met and that the grants 
will be received. Significant judgement is required in 
determining the income tax refund eligibility. There are 
many transactions and calculations undertaken during 
the ordinary course of business for which the ultimate 
tax determination is uncertain. The amounts recorded 
as revenue for the financial years ended 30 June 2024 
and 2023 relate to tax refunds received in the same 
financial year following tax returns lodged claiming eligible 
expenditure Incurred In the previous financial year.  
Estimated Useful Lives of Other Intangible Assets
Other intangible assets comprise licences and are stated at 
cost less accumulated amortisation. Rhythm determines the 
estimated useful lives and related amortisation charges for 
its finite life intangible assets. The useful lives could change 
significantly as a result of technical innovations or some 
other event. The amortisation charge will increase where 
the useful lives are less than previously estimated lives, or 
technically obsolete or non-strategic assets that have been 
abandoned or sold will be written off or written down.
Provision for Impairment of Inventories
The provision for impairment of inventories assessment 
requires a degree of estimation and judgement. The 
level of the provision is assessed by taking into account 
expected future sales, the ageing of inventories and other 
factors that affect inventory obsolescence. 
Adoption of New and Revised Accounting Standards
During the current year, the Group has adopted all of 
the new and revised Australian Accounting Standards 
and Interpretations applicable to its operations which 
became mandatory.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
32
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

New Accounting Standards for Application in Future Periods
The Board has not yet assessed the impact of the new, but not yet mandatory, accounting standards issued by Australian 
Accounting Standards Board (AASB).
Note 2: Parent Information
2024 ($)
2023 ($)
Statement of Financial Position
Current assets
1,114,815
4,052,048
Non-current assets
403,893
2,346,158
Total Assets
1,518,708
6,398,206
Current liabilities
483,491
468,373
Non-Current Liabilities
168,051
55,382
Total Liabilities
651,542
523,755
Issued Capital
34,448,096
31,550,602
Reserves
5,093,243
6,141,261
Accumulated losses
(38,674,173)
(31,817,412)
Total Equity
867,166
5,874,451
Statement of Comprehensive Income
2024 ($)
2023 ($)
Total loss
(6,856,761)
(8,217,557)
Total Comprehensive Income
(6,856,761)
(8,217,557)
Guarantees
The Parent Company has entered into a Deed of Cross Guarantee with the effect 
that the Company guarantees debts in respect of its subsidiary Vision Tech Pty Ltd. 
Further details of the Deed of Cross Guarantee and the subsidiary to the deed are 
set out in Note 23.
Commitments and Contingent Liabilities
At 30 June 2024, the Parent Company had no capital commitments and no 
contingent liabilities (2023: Nil).
Significant Accounting Policies
The accounting policies of the parent entity are consistent with those of the 
consolidated entity, as disclosed in Note 1, except for investments in subsidiaries 
which are accounted for at cost, less any impairment, in the parent entity.
 
33

Note 3: Income
2024 ($)
2023 ($)
Interest Income
52,282
228,270
Government Grant Income 
-
15,000
Research and Development Tax Refund
1,690,144
3,080,545
Other sundry income
-
297
Total 
1,742,426
3,324,112
Note 4: Employment Related Costs
2024 ($)
2023 ($)
Staff salaries and Director fees
2,097,522
2,739,970
Superannuation
238,696
288,258
Share-based payments expense (Refer to Note 17 for options and 
shares issued)
(1,048,018)
3,003,935
Other employment related expenses
301,979
266,741
Total
1,590,179
6,298,904
Note 5: Income Tax
2024 ($)
2023 ($)
Prima facie income tax benefit before income tax at 25% (2023: 25%)
1,714,190
2,054,389
Add/(subtract) tax effect:
- Research and development claim
422,536
770,136
- Share based payments expense
262,005
(750,984)
- Other non-deductible expenditure
(14,010)
(11,500)
- Tax losses and temporary differences not brought to account
(2,384,721)
(2,062,041)
Income tax expense
-
-
 Tax losses of $5,681,511 (2023: $4,089,419) and temporary differences of $86,857 (2023: $169,811) have not brought to account on the basis that their recovery is 
not considered probable at balance date.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
34
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Note 6: Loss Per Share
2024 ($)
2023 ($)
The following reflects the income and share data used in the 
calculations of basic and diluted loss per share:
Loss used in calculating basic and diluted earnings per share
(6,856,761)
(8,217,557)
2024 
No. of Shares
2023 
No. of Shares
Weighted average number of ordinary shares used in calculating 
basic loss per share
228,296,917
216,893,990
Basic and diluted loss per share (cents)
(3.00)
(3.79)
Calculation of diluted loss per share
Potential ordinary shares are considered to be antidilutive, therefore 
diluted loss per share is equivalent to the basic loss per share.
Note 7: Trade and Other Receivables
2024 ($)
2023 ($)
GST receivable
37,199
65,513
Note 8: Inventories
2024 ($)
2023 ($)
Raw materials – at cost
-
2,766,682
Reconciliation of movement in net carrying value
Balance at the beginning of the year
2,766,682
-
Additions
225,619
2,766,682
Transfers from prepayments 
59,315
-
Impairment (i)
(3,047,516)
-
Disposals
(4,100)
-
Balance at the end of the period
-
2,766,682
(i)Following a strategic review, inventory on hand is to be used for research and development use rather than commercial sales. As a consequence, the 
consolidated entity’s ColoSTAT® kits recorded as raw materials inventory were impaired to nil having regard to the expectation that the consolidated entity does 
not anticipate any material revenue to be earned in future years from existing ColoSTAT® kits on hand. Future revenue will be dependent on completion of in vitro 
diagnostic medical devices regulation standards (‘IVDR’) transition work and then obtaining regulatory approvals for the new IVDR compliant kits.
35

Note 9: Intangible Assets
2024 ($)
2023 ($)
Intellectual Property
Licences at cost (i)
600,000
600,000
Licences accumulated amortisation (i)
(245,898)
(209,927)
354,102
390,073
2024 ($)
2023 ($)
Movement in Carrying Amounts:
Balance at the beginning of the year
390,073
426,044
Amortisation (i)
(35,971)
(35,971)
Balance at the end of the year
354,102
390,073
(i) A licence was granted by the Commonwealth Scientific and Industrial Research Organisation ("CSIRO") on 23 August 2017 and is being amortised over a 
period of 17 years based on contract terms.  This has been assessed as the expected useful life of the intangible asset.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
36
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Note 10: Property, Plant and Equipment
2024 ($)
2023 ($)
Computers – at cost
91,718
90,020
Accumulated depreciation
(76,742)
(60,399)
14,976
29,621
Office equipment – at cost
36,063
36,063
Accumulated depreciation
(14,283)
(6,266)
21,780
29,797
Laboratory equipment - at cost
328,845
248,262
Accumulated depreciation
(252,442)
(202,767)
76,403
45,495
Total
113,159
104,913
Movement in Carrying Amounts 2024:
Computer 
Equipment ($)
Office 
Equipment ($)
Laboratory
Equipment ($)
Total ($)
Balance at the beginning of the year
29,621
29,797
45,495
104,913
Additions
1,698
-
80,583
82,281
Depreciation
(16,343)
(8,017)
(49,675)
(74,035)
Balance at the end of the year
14,976
21,780
76,403
113,159
Movement in Carrying Amounts 2023:
Computer 
Equipment ($)
Office 
Equipment ($)
Laboratory
Equipment ($)
Total ($)
Balance at the beginning of the year
16,125 
10,534
43,640
70,299
Additions
28,973
23,818
46,331
99,122
Depreciation
(15,477)
(4,555)
(44,476)
(64,508)
Balance at the end of the year
29,621
29,797
45,495
104,913
37

Note 11: Trade and Other Payables
2024 ($)
2023 ($)
Trade creditors
211,609
1,333,906
Accruals 
248,100
188,937
Balance at the end of the year
459,709
1,522,843
Note 12: Provisions
2024 ($)
2023 ($)
Current
Provision for Annual Leave
23,782
158,139
Non-Current
Provision for Long Service Leave
4,229
55,383
28,011
213,522
Note 13: Issued Capital
2024 (No.)
2023 (No.)
2024 ($)
2023 ($)
Ordinary shares fully paid
Balance at the beginning of the year
219,792,589
214,082,145
31,550,602
27,834,579
Rights issue and placement at 10 cents per share
27,454,161
-
2,745,416
-
Options exercised
1,350,000
5,710,444
270,000
3,740,240
Capital raising costs
-
-
(117,922)
(24,217)
Balance at the end of the year
248,596,750
219,792,589
34,448,096
31,550,602
Ordinary shares
Ordinary shares entitle the holder to participate in dividends and the proceeds on the winding up of the Company in 
proportion to the number of and amounts paid on the shares held. Ordinary shares have no par value and the company 
does not have a limited amount of authorised capital. On a show of hands every member present at a meeting in person 
or by proxy shall have one vote and upon a poll each share shall have one vote.
Capital risk management
The consolidated entity's objectives when managing capital is to safeguard its ability to continue as a going concern, 
so that it can provide returns for shareholders and benefits for other stakeholders and to maintain an optimum capital 
structure to reduce the cost of capital. 
Capital is regarded as total equity, as recognised in the statement of financial position, plus net debt. Net debt is 
calculated as total borrowings less cash and cash equivalents. In order to maintain or adjust the capital structure, the 
consolidated entity may adjust the amount of dividends paid to shareholders, return capital to shareholders, issue new 
shares or sell assets to reduce debt. The consolidated entity would look to raise capital when an opportunity to invest 
further into development and commercialisation or in a business seen as value adding relative to the current Company's 
share price at the time of the investment. The consolidated entity is not actively pursuing additional investments in the 
short term as it continues to integrate and grow its existing businesses in order to maximise synergies. The capital risk 
management policy remains unchanged from 30 June 2023.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
38
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Note 14: Reserves
Notes
2024 ($)
2023 ($)
Share Based Payments Reserve
Balance at the beginning of the year
6,141,261
3,137,326
Share-based payments (reversal)/expense
17
(1,048,018)
3,003,935
Balance at the End of the Year
5,093,243
6,141,261
Share based payments reserve is used to record the value of equity benefits provided to Directors, employees and 
consultants as part of their remuneration.
.Note 15: Cash Flow Information
Notes
2024 ($)
2023 ($)
a. 	 Cash at the end of the financial year as shown in the cash flow 
statement is reconciled to the related items in the balance sheet 
as follows:
Cash at bank
709,496
4,124,181
709,496
4,124,181
b.	 Reconciliation of cash flow from operating activities with loss after 
income tax benefit
Loss after income tax
(6,856,761)
(8,217,557)
Non-Cash Items
Depreciation and amortisation
198,660
189,377
Expense/(reversals) recognised in respect of equity-settled share-based 
payments
(1,048,018)
3,003,935
Changes In Assets and Liabilities
Decrease/(Increase) in trade and other receivables
28,315
16,902
Decrease/(Increase) in prepayments
22,596
(24,370)
Decrease/(Increase) in inventories
2,766,682
(2,766,682)
(Decrease)/Increase in trade and other payables
(1,063,134)
891,906
(Decrease)/Increase in provision for employee entitlements
(185,511)
(51,121)
Net Cash Used In Operating Activities
(6,137,171)
(6,957,610)
Note 16: Related Party Transactions
Rhythm Biosciences Limited is the parent entity. Refer to Note 22 for details on the subsidiaries.		
	
The names of each person holding the position of director of Rhythm Biosciences Limited during the year were Mr Otto 
Buttula, Dr Trevor Lockett, Mr Lou Panaccio, Dr Rachel David (resigned 28 December 2023) and Ms Susan MacLeman. 
Company secretaries were Ms Andrea Steele, Mr Paul Smith (resigned 15 November 2023) and Mr James Barrie 
(appointed 1 January 2024).
39

During the 2024 financial year the Company granted 4,200,000 options to key management personnel as part of their 
remuneration. Vesting conditions related to these options not yet achieved are as follows:
In respect to Ms MacLeman:
•	 33.3% upon remaining employed on 30 November 2025.
In respect to Dr Atkins:
•	 50% upon remaining employed on 12 May 2025; and
•	 50% upon remaining employed on 12 May 2026.
Dr Atkins’ remuneration also included 4,000,000 Loan Funded Shares at $0.10 (4 year non-recourse loan at 0% interest 
rate). Vesting conditions related to these Loan Funded Shares not yet achieved are as follows:
•	 50% upon remaining employed on 12 May 2025; and
•	 50% upon remaining employed on 12 May 2026.
During the 2023 financial year the Company granted 10,950,000 options to key management personnel and other 
employees as part of their remuneration. Vesting conditions related to these options not yet achieved are as follows:
•	 25% upon the Company achieving first revenue from 2 other countries by December 2024; and
•	 25% upon remaining employed on 31 December 2025.
During the 2022 financial year the Company granted 8,195,000 options to consultants, key management personnel and 
other employees as part of their remuneration.  Vesting conditions related to these options not yet achieved as at 30 June 
2024 are as set out below.
In respect to Mr Buttula, Mr Panaccio, Dr Lockett and employees:
•	 25% upon remaining employed on 21 July 2024.
Set out below are summaries of Options granted. Options include amounts cancelled subsequent to balance date as 
announced on the ASX.
Unvested Options shall lapse upon employment termination without notice (with cause) or cessation.
An expense reversal of $1,048,018 (2023: $3,003,935 expensed) for Options and loan funded shares is included in the 
Statement of profit or loss and other comprehensive income which arose as a result of service conditions not being met 
and consequently Options lapsing prior to the vesting date. Details are as follows:
Grant Date
Expiry Date Exercise Price
Balance at Start 
of the Year
Granted
Lapsed
Exercised 
Balance at 
End of the Year
Vested
14.9.2020
14.9.2023
$0.20
587,500
-
(362,500)
(225,000)
-
-
18.11.2020
14.9.2023
$0.20
1,125,000
-
-
(1,125,000)
-
-
26.7.2021
31.7.2024
$1.80
807,500
-
(595,000)
-
212,500
53,125
26.7.2021
31.7.2024
$1.80
1,000,000
-
-
-
1,000,000
1,000,000
24.11.2021
31.7.2024
$1.80
1,450,000
-
-
-
1,450,000
787,500
29.11.2022
31.12.2025
$1.80
150,000
-
(150,000)
-
-
-
31.12.2022
31.12.2025
$1.80
7,800,000
-
(4,800,000)
-
3,000,000
750,000
10.10.2023
30.11.2025
$1.80
-
200,000
-
-
200,000
50,000
13.5.2024
31.3.2026
$0.20
-
2,000,000
-
-
2,000,000
-
13.5.2024
31.3.2028
$0.30
-
2,000,000
-
-
2,000,000
-
TOTAL
12,920,000
4,200,000
(5,907,500)
(1,350,000)
9,862,500
2,640,625
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
40
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

The valuation model inputs used to determine the fair value at the grant date, are as follows:
Grant Date
Expiry Date
Share Price at 
Grant Date
Exercise Price
Expected 
Volatility
Dividend Yield 
Risk-free 
Interest Rate*
Fair Value at 
Grant Date
14.9.2020
14.9.2023
$0.145
$0.20
100%
-
0.24%
$0.0799
18.11.2020
14.9.2023
$0.47
$0.20
100%
-
0.11%
$0.3545
** 26.7.2021
31.7.2024
$0.93
$1.80
100%
-
0.13%
$0.45
24.11.2021
31.7.2024
$1.74
$1.80
100%
-
1.01%
$1.02
29.11.2022
31.12.2025
$1.10
$1.80
100%
-
3.20%
$0.59
31.12.2022
31.12.2025
$1.02
$1.80
100%
-
3.30%
$0.53
10.10.2023
30.11.2025
$0.32
$1.80
100%
-
3.97%
$0.06
13.5.2024
31.3.2026
$0.079
$0.20
100%
-
3.965%
$0.02
13.5.2024
31.3.2026
$0.079
$0.30
100%
-
3.965%
$0.04
*** 13.5.2024
31.3.2028
$0.079
$0.30
100%
-
3.965%
$0.04
* The risk-free interest rate is based on the Australian Government 3-year bond yield (Reserve Bank of Australia website) at the grant date.
** On 26 July 2021 when the share price was $0.93, Directors resolved to issue these Options, subject to receipt of shareholder approval. On 24 November 2021, 
when the share price was $1.74, shareholder approval occurred at the Annual General Meeting (AGM). The fair value for accounting purposes is determined 
based upon final approval at the date of the AGM.
*** Loan funded shares.
A share option plan has been established by the consolidated entity, whereby the consolidated entity may, at the 
discretion of the Board, grant options over ordinary shares in the Company to certain key management personnel of 
the consolidated entity. The options are issued for nil consideration and are granted in accordance with performance 
guidelines established by the Board. In addition, the Company has also issued loan funded shares pursuant to an 
employment agreement with the CEO.
All options granted are in respect of ordinary shares in Rhythm Biosciences Limited and confer a right of one ordinary 
share for each option held.
Movement in the number of share options on issue to Directors, employees and third parties
2024
2024
2023
2023
Number of 
Options
Weighted Average 
Exercise Price (cents)
Number of 
Options
Weighted Average 
Exercise Price (cents)
Opening balance
12,920,000
158.60
15,232,500
103.06
Granted
4,200,000
32.38
10,950,000
180.00
Forfeited / Lapsed
(5,907,500)
170.18
(9,687,500)
146.75
Exercised
(1,350,000)
20.00
(3,575,000)
20.00
Outstanding at year-end
9,862,500
117.14
12,920,000
158.60
Exercisable at year-end
2,640,625
180.00
5,891,250
133.02
The fair value of issued share-based payments granted during the year pursuant to the ESOP in 2024 was calculated to 
be $332,000 (2023: $5,812,500). The total amount in the income statement is a share-based payments expense reversal 
of $1,048,018 (2023: $3,003,935 expensed) for Options and Loan Funded Shares in the current and previous years. 
41

The value of share options issued has been calculated by using a Black-Scholes option pricing model applying the 
following inputs:
S MacLeman
D Atkins
D Atkins
D Atkins
Options granted
200,000
2,000,000
1,000,000
1,000,000
Grant date
10.10.2023
13.5.2024
13.5.2024
13.5.2024
Exercise price
$1.80
$0.20
$0.30
$0.30
Underlying share price
$0.32
$0.079
$0.079
$0.079
Expiry date
30.11.2025
31.3.2026
31.3.2026
31.3.2028
Vesting period
various
12 mths
12 mths
24 mths
Expected share price volatility
100%
100%
100%
100%
Risk free interest rate
3.97%
3.965%
3.965%
3.965%
Fair value per option at grant 
date
$0.06
$0.02
$0.04
$0.04
Total fair value at grant date
$12,000
$40,000
$40,000
$40,000
The life of the options is based on the contracted expiry date.
The value of loan funded shares issued has been calculated by using a Black-Scholes option pricing model applying the 
following inputs:
D Atkins
D Atkins
Loan funded shares granted
2,000,000
2,000,000
Grant date
13.5.2024
13.5.2024
Issue price
$0.10
$0.10
Underlying share price
$0.079
$0.079
Expiry date
12.5.2028
12.5.2028
Vesting period
12 mths
24 mths
Expected share price volatility
100%
100%
Risk free interest rate
3.965%
3.965%
Fair value per option at grant date
$0.05
$0.05
Total fair value at grant date
$100,000
$100,000
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
42
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Note 18: Financial Risk Management
The Group’s financial instruments consist mainly of term deposits with banks, other receivables and trade payables.
The totals for each category of financial instruments, measured in accordance with AASB 9 as detailed in the accounting 
policies to these financial statements, are as follows:
2024 ($)
2023 ($)
Financial Assets
Cash and cash equivalents
709,496
4,124,181
Trade and other receivables
37,199
65,513
Other financial assets – term deposits
45,000
45,000
791,695
4,234,694
Financial Liabilities
Trade and other Payables
459,709
1,522,843
459,709
1,522,843
There are no impaired assets within trade and other receivables; these balances, and the balance of trade and other 
payables, are expected to be settled within 1 year.
Financial Assets Pledged as Collateral 
No financial assets have been pledged as security for any financial liability.
Financial Risk Management Policies
The Board are responsible for, among other issues, monitoring and managing financial risk exposures of the Group. The 
Board monitors the Group’s transactions and reviews the effectiveness of controls relating to credit risk, liquidity risk, and 
market risk. Discussions on monitoring and managing financial risk exposures are held regularly by the Board. The Board’s 
overall risk management strategy seeks to ensure that the Group meets its financial targets, while minimising potential 
adverse effects of cash flow shortfalls.
The Group did not have any derivative instruments at 30 June 2024.
Specific Financial Risk Exposures and Management
The main risk the Group is exposed to through its financial instruments is liquidity risk.
Credit Risk
Exposure to credit risk relating to financial assets arises from the potential non-performance by counterparties of 
contract obligations that could lead to a financial loss to the Group.
Credit risk is managed through maintaining procedures ensuring, to the extent possible, that members and 
counterparties to transactions are of sound credit worthiness. 
Credit risk exposures
Cash reserves form the majority of the Group’s financial assets. At 30 June 2024, cash was deposited with a large 
Australian bank in order to limit risk and ensure interest rate competitiveness. 
43

Liquidity Risk
Liquidity risk arises from the possibility that the Group might encounter difficulty in settling its debts or otherwise 
meeting its obligations related to financial liabilities. The Group manages this risk through the following mechanisms:
•	 preparing forward-looking cash flow analysis in relation to its operational, investing and financing activities; and
•	 only investing surplus cash with major financial institutions.
Market Risk
Interest rate risk
Interest rate risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate as a result of 
changes in market interest rates. Exposure to interest rate risk arises on interest earned on cash and cash equivalents and 
term deposits.
The consolidated entity's cash and cash equivalents and term deposits were $754,496 as at 30 June 2024 (2023: 
$4,169,181). An official increase/decrease in interest rates of 100 (2023: 100) basis points would have an adverse/
favourable effect on loss before tax of $7,545 (2023: $41,692) per annum. The percentage change is based on the 
expected volatility of interest rates using market data and analysts' forecasts. 
Variable rate instruments were cash held at financial Instruments of $709,496 (2023: $4,124,181). Fixed rate instruments 
were term deposits held at financial Institutions of $45,000 (2023: $45,000). 
Price risk
Price risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate as a result of changes in 
market prices. The Group is not exposed to price risk.
Currency risk
Currency risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate due to changes in 
foreign exchange rates. The Group's exposure to currency risk is minimal at present as the majority of transactions are in 
Australian dollars.
Note 19: Segment Reporting
In accordance with Australian Accounting Standard AASB 8 Operating Segments, the Company has determined that it has 
one reporting segment, consistent with the manner in which the business is managed. This is the manner in which the chief 
operating decision maker receives information for the purpose of resource allocation and assessment of performance. 
The Group operates predominantly in one business and geographical segment being the research and development of 
biosciences in Victoria, Australia.
Note 20: Key Management Personnel Compensation
The Key Management Personnel compensation included in employee expenses are as follows:
Share-based 
payments ($)
Short-term 
benefits ($)
Termination 
benefits ($)
Post-employment 
benefits ($)
Other Long-term 
benefits ($)
Total ($)
2024
Total compensation
5,232
664,175
-
73,774
-
743,181
2023
Total compensation
1,225,131
936,845
96,688
101,653
(16,443)
2,343,874
Further details on the above remuneration is disclosed in the Remuneration Report in the Directors’ report.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
44
FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 JUNE 2024

Note 21: Auditor Remuneration
2024 ($)
2023 ($)
Remuneration of the Auditor of the Group for:
Auditing or reviewing the financial report
92,556
65,433
Other services:
- Taxation advice
13,100
25,280
105,656
90,713
Note 22: Controlled Entities
Controlled Entities Consolidated
Country of 
Incorporation
 Percentage Owned 
(%) 2024
Percentage Owned 
(%) 2023
Vision Tech Bio Pty Ltd
Australia
100%
100%
IchorDX Inc,
United States
100%
100%
Rhythm Biosciences UK Limited 
United Kingdom
100%
100%
* Percentage of voting power in proportion to ownership

Note 23: Deed of Cross Guarantee
A Deed of Cross Guarantee was lodged with the ASIC on 18 April 2023 covering Rhythm Biosciences Limited and Vision 
Tech Pty Ltd. The assets and liabilities of the companies within the Deed are as stated in the financial statements as at 30 
June 2024.
Note 24: Events Subsequent to Reporting Date
On 14  August 2024, the Company announced on the ASX it entered into a secured loan facility agreement (Loan) which 
will provide early access to $1,150,000 cash of its forecast ~$1,500,000 FY24 R&D Tax Incentive (RDTI Rebate) expected 
to be received in full by November 2024.
The Loan is secured by and repayable out of the FY24 RDTI Rebate and attracts a fixed 1.33% per month interest rate. It 
matures on 31 December 2024, however, can be extended by agreement between the lender and Rhythm. This Loan is 
intended to be used in a bridging period prior to receiving the FY24 RDTI Rebate, along with the amended FY23 RDTI 
rebate for overseas activities. 
There has been no other matters or circumstances which have arisen since 30 June 2024 that has significantly affected or 
may significantly affect:
•	 the operations, in financial years subsequent to 30 June 2024, of the consolidated entity; or
•	 the results of those operations; or 
•	 the state of affairs, in financial years subsequent to 30 June 2024, of the consolidated entity. 
Note 25: Commitments
The Group has inventory purchase commitments of $nil (2023: $265,193) for goods not yet received as at 30 June 2024. 
There are no capital commitments for expenditure as at 30 June 2024 (2023: $nil). 
Note 26: Contingent Assets and Liabilities
The Group has no contingent assets or liabilities as at 30 June 2024 (2023: $nil).
45

Controlled Entities Consolidated
Country of 
Incorporation
 Percentage Owned 
(%) 
Tax 
Residency
Vision Tech Bio Pty Ltd
Australia
100%
Australia
IchorDX Inc,
United States
100%
United States
Rhythm Biosciences UK Limited 
United Kingdom
100%
United Kingdom
The parent entity is Rhythm Biosciences Ltd incorporated in and with a tax residency in Australia. In addition, all entities are a 
Body Corporate.
Basis of Preparation
The Consolidated Entity Disclosure Statement (CEDS) has been prepared in accordance with the Corporations Act 2001. 
It includes certain information for each entity that was part of the consolidated entity at the end of the financial year.
Determination of Tax Residency
Section 295(3A) of the Corporations Act 2001 defines tax residency as having the meaning in the Income Tax Assessment 
Act 1997. The determination of tax residency involves judgement as there are currently different interpretations that could 
be adopted and which could give rise to a different conclusion on residency. 
Australian Tax Residency
The consolidated entity has applied current legislation and judicial precedent, including having regard to the  tax 
Commissioner's public guidance in Tax Ruling TR 2018/5.
Foreign Tax Residency
Where necessary, the consolidated entity has used independent tax advisors in foreign jurisdictions to assist in determining 
tax residency and ensure compliance with applicable foreign tax legislation.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
46
CONSOLIDATED ENTITY DISCLOSURE STATEMENT

The Directors declare that:
1.	 The financial statements and notes, as set out on pages  25 to 45 are in accordance with the Corporations Act 2001, 
and:
a.	 comply with Australian Accounting Standards, the Corporations Regulations 2001 and other mandatory 
professional reporting requirements; and
b.	 give a true and fair view of the Consolidated Entity’s financial position as at 30 June 2024 and of its performance 
for the year ended on that date;
2.	 The attached financial statements and notes comply with International Financial Reporting Standards as issued by the
International Accounting Standards Board as described in note 1 to the financial statements;
3.	 The consolidated entity disclosure statement on page 46 is true and correct;
4.	 The Chief Executive Officer and Chief Finance Officer have provided the declarations as required by section 295A of 
the Corporations Act 2001 to the Company;
5.	 In the Directors’ opinion, subject to the matters disclosed in note 1, there are reasonable grounds to believe that the 
entity will be able to pay its debts as and when they become due and payable; 
6.	 Remuneration disclosures on pages 15 to 21 comply with section 300A of the Corporations Act 2001; and
7.	 There are reasonable grounds to believe that the Company and the group entity indentified in Note 23 will be able 
to meet any obligations or liabilities to which they are or may become subject to by virture of the Deed of Cross 
Guarantee between the Company and group entity persuant to ASIC Corporations (wholly owned Companies) 
Instrument 2016/785.
This declaration is made in accordance with a resolution of the Directors pursuant to section 295(5)(a) of the 
Corporations Act 2001.
Otto Buttula
Non-Executive Chairman
Melbourne, Australia
Dated this 30th day of August 2024
47
DIRECTORS' DECLARATION

Tel: +61 3 9603 1700 
Fax: +61 3 9602 3870 
www.bdo.com.au 
Collins Square, Tower Four 
Level 18, 727 Collins Street 
Melbourne VIC 3008 
GPO Box 5099 Melbourne VIC 3001 
Australia 
BDO Audit Pty Ltd ABN 33 134 022 870 is a member of a national association of independent entities which are all members of BDO 
Australia Ltd ABN 77 050 110 275, an Australian company limited by guarantee. BDO Audit Pty Ltd and BDO Australia Ltd are members of 
BDO International Ltd, a UK company limited by guarantee, and form part of the international BDO network of independent member 
firms. Liability limited by a scheme approved under Professional Standards Legislation. 
INDEPENDENT AUDITOR'S REPORT 
To the members of Rhythm Biosciences Limited 
Report on the Audit of the Financial Report 
Opinion 
We have audited the financial report of Rhythm Biosciences Limited (the Company) and its subsidiaries 
(the Group), which comprises the consolidated statement of financial position as at 30 June 2024, the 
consolidated statement of profit or loss and other comprehensive income, the consolidated statement 
of changes in equity and the consolidated statement of cash flows for the year then ended, and notes 
to the financial report, including material accounting policy information, the consolidated entity 
disclosure statement and the directors’ declaration. 
In our opinion the accompanying financial report of the Group, is in accordance with the Corporations 
Act 2001, including:  
(i)
Giving a true and fair view of the Group’s financial position as at 30 June 2024 and of its
financial performance for the year ended on that date; and
(ii)
Complying with Australian Accounting Standards and the Corporations Regulations 2001.
Basis for opinion 
We conducted our audit in accordance with Australian Auditing Standards.  Our responsibilities under 
those standards are further described in the Auditor’s responsibilities for the audit of the Financial 
Report section of our report.  We are independent of the Group in accordance with the Corporations 
Act 2001 and the ethical requirements of the Accounting Professional and Ethical Standards Board’s 
APES 110 Code of Ethics for Professional Accountants (including Independence Standards) (the Code) 
that are relevant to our audit of the financial report in Australia.  We have also fulfilled our other 
ethical responsibilities in accordance with the Code. 
We confirm that the independence declaration required by the Corporations Act 2001, which has been 
given to the directors of the Company, would be in the same terms if given to the directors as at the 
time of this auditor’s report. 
We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis 
for our opinion.  
Material uncertainty related to going concern 
We draw attention to Note 1 in the financial report which describes the events and/or conditions which 
give rise to the existence of a material uncertainty that may cast significant doubt about the Group’s 
ability to continue as a going concern and therefore the Group may be unable to realise its assets and 
discharge its liabilities in the normal course of business. Our opinion is not modified in respect of this 
matter. 
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
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INDEPENDENT AUDITOR’S  REPORT

INDEPENDENT AUDITOR’S REPORT
Key audit matters 
Key audit matters are those matters that, in our professional judgement, were of most significance in 
our audit of the financial report of the current period.  These matters were addressed in the context of 
our audit of the financial report as a whole, and in forming our opinion thereon, and we do not provide 
a separate opinion on these matters. In addition to the matter described in the Material uncertainty 
related to going concern section, we have determined the matters described below to be the key audit 
matters to be communicated in our report. 
Key audit matter 
How the matter was addressed in our audit 
Research and Development Grant Income 
Recognition 
Other income includes a research and development 
(“R&D”) tax refund and Note 1 to the annual financial 
report discloses the accounting policy used by the 
Group for the recognition and measurement of its R&D 
tax refund income. 
Recognition of the R&D tax refund income was 
considered a key audit matter due to the significance 
of the recorded amount and the inherent subjectivity 
associated with the calculation performed to 
determine the R&D tax refund income amount, 
including the assessment of eligibility criteria met in 
respect of regulatory requirements applicable to the 
R&D tax refund income. 
Our procedures included, but were not limited to: 
•
Assessing the Group’s accounting policy for
refundable R&D tax offsets for compliance with
Australian Accounting Standards.
•
Assessing the adequacy of procedures and key
internal controls surrounding the recording of
income.
•
Engaging our internal R&D tax specialist team to
evaluate management’s assessment of whether the
R&D expenditure claimed is eligible expenditure
under the criteria of the Income Tax Assessment
Act 1997 and relevant regulatory registrations
obtained for the R&D expenditure activities.
•
Vouching a sample of R&D expenditure items
claimed to underlying internally and externally
sourced documentary evidence, including
reperforming calculations used to determine the
R&D tax refund amount.
•
Vouching the cash proceeds for the R&D tax refund
income to the relevant documentary evidence such
as the lodged income tax return, bank statements
and the relevant income tax assessment notice.
•
Checking the completeness and appropriateness of
the disclosures within the annual financial report.
49

Key audit matter 
How the matter was addressed in our audit 
Measurement of Share Based Payments and Loan 
Funded Shares  
A net reversal of share-based payment expenses was 
recognised for the financial impact of options that 
were granted in prior periods. In addition, share based 
payments were expensed during the year relating to 
options and loan funded shares issued during the 30 
June 2024 financial year to key management 
personnel.   
Share-based payments are a complex accounting area, 
and due to this complexity and judgements used in 
determining the fair value of the share-based 
payments and the probability of vesting conditions 
being achieved, we consider the Group’s calculation of 
the share-based payment expense to be a key audit 
matter. 
Refer to Note 1 and Note 17 of the financial report for 
a description of the accounting policy and significant 
estimates and judgements applied to the share-based 
payment net reversal of expense recorded in the 2024 
annual financial statements.   
Our procedures included, but were not limited to: 
•
Reviewing board minutes and ASX announcements
for the completeness of share-based payments and
loan funded shares issued during the year.
•
Engaging our internal valuation expert to calculate
an appropriate valuation range, including
assessment of inputs used in management’s
valuations, for the new options and loan funded
shares issued during the year. We compared the
valuation range derived to the fair values used by
management to record the share based payment
expenses.
•
Reviewing a sample of underlying agreements
related to the issuance of any new share-based
payments and loan funded shares in addition to
assessing whether there have been any
modifications in the agreements in place from
prior years.
•
Evaluating the reasonableness of key estimates
applied by management in determining the
probability percentages of the various
performance-based vesting conditions.
•
Assessing whether the recognition of the current
year’s share-based payment and loan funded
shares expense and net reversal of expense and
corresponding reserve balance movement were
materially correct based on conditions stipulated
within the underlying agreements.
•
Checking the adequacy of the related disclosures
within the annual financial report.
Other information 
The directors are responsible for the other information.  The other information comprises the 
information contained in the Directors’ report for the year ended 30 June 2024, but does not include 
the financial report and our auditor’s report thereon, which we obtained prior to the date of this 
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
50
INDEPENDENT AUDITOR’S  REPORT

auditor’s report, and the Chairman’s report, which is expected to be made available to us after that 
date. 
Our opinion on the financial report does not cover the other information and we do not express any 
form of assurance conclusion thereon.  
In connection with our audit of the financial report, our responsibility is to read the other information 
identified above and, in doing so, consider whether the other information is materially inconsistent 
with the financial report or our knowledge obtained in the audit or otherwise appears to be materially 
misstated.  
If, based on the work we have performed on the other information that we obtained prior to the date 
of this auditor’s report, we conclude that there is a material misstatement of this other information, 
we are required to report that fact. We have nothing to report in this regard.  
When we read the Executive Chairman’s report, if we conclude that there is a material misstatement 
therein, we are required to communicate the matter to the directors and will request that it is 
corrected.  If it is not corrected, we will seek to have the matter appropriately brought to the 
attention of users for whom our report is prepared. 
Responsibilities of the directors for the Financial Report  
The directors of the Company are responsible for the preparation of: 
a)
the financial report that gives a true and fair view in accordance with Australian Accounting
Standards and the Corporations Act 2001 and
b)
the consolidated entity disclosure statement that is true and correct in accordance with the
Corporations Act 2001, and
for such internal control as the directors determine is necessary to enable the preparation of: 
i) the financial report that gives a true and fair view and is free from material misstatement, whether
due to fraud or error; and
ii) the consolidated entity disclosure statement that is true and correct and is free of misstatement,
whether due to fraud or error.
In preparing the financial report, the directors are responsible for assessing the ability of the group to 
continue as a going concern, disclosing, as applicable, matters related to going concern and using the 
going concern basis of accounting unless the directors either intend to liquidate the Group or to cease 
operations, or has no realistic alternative but to do so.  
Auditor’s responsibilities for the audit of the Financial Report 
Our objectives are to obtain reasonable assurance about whether the financial report as a whole is free 
from material misstatement, whether due to fraud or error, and to issue an auditor’s report that 
includes our opinion.  Reasonable assurance is a high level of assurance, but is not a guarantee that an 
audit conducted in accordance with the Australian Auditing Standards will always detect a material 
misstatement when it exists.  Misstatements can arise from fraud or error and are considered material 
if, individually or in the aggregate, they could reasonably be expected to influence the economic 
decisions of users taken on the basis of this financial report.  
51

A further description of our responsibilities for the audit of the financial report is located at the 
Auditing and Assurance Standards Board website at:  
https://www.auasb.gov.au/admin/file/content102/c3/ar1_2020.pdf 
This description forms part of our auditor’s report. 
Report on the Remuneration Report 
Opinion on the Remuneration Report 
We have audited the Remuneration Report included in pages 15 to 21 of the directors’ report for the 
year ended 30 June 2024. 
In our opinion, the Remuneration Report of Rhythm Biosciences Limited, for the year ended 30 June 
2024, complies with section 300A of the Corporations Act 2001.  
Responsibilities 
The directors of the Company are responsible for the preparation and presentation of the 
Remuneration Report in accordance with section 300A of the Corporations Act 2001.  Our responsibility 
is to express an opinion on the Remuneration Report, based on our audit conducted in accordance with 
Australian Auditing Standards. 
BDO Audit Pty Ltd 
Tony Batsakis 
Director 
Melbourne, 30 August 2024 
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
52
INDEPENDENT AUDITOR’S  REPORT

Rhythm Biosciences Ltd is quoted on the Australian Securities Exchange (ASX) under the ticker code RHY. The following 
information was extracted from the Company’s records as at 15 August 2024 and is required by the ASX Listing Rules. 
Rhythm’s securities are not quoted on any other stock exchange. 
Twenty Largest Holders of Ordinary Shares
Rank
Shareholder
Number of Fully Paid 
Ordinary Shares
Percentage of Total 
Issued Capital
1
WEBINVEST PTY LTD
22,479,168
9.04
2
NEWFOUND INVESTMENTS PTY LTD
13,905,407
5.59
3
FERNDALE SECURITIES PTY LTD
10,300,000
4.14
4
HSBC CUSTODY NOMINEES (AUSTRALIA) LIMITED
9,269,796
3.73
5 
LOUMEA INVESTMENT PTY LTD
8,052,520
3.24
6
NORTHERN STAR NOMINEES PTY LTD
7,380,000
2.97
7
ROJO NERO CAPITAL PTY LTD 
4,213,751
1.70
8
GIOKIR PTY LTD
3,661,470
1.47
9
MR HSIEN MICHAEL SOO
3,305,403
1.33
10
MR MARK ANTHONY ROGERS & MR ARTHUR NICHOLAS VELISS
3,000,000
1.21
11
DC & PC HOLDINGS PTY LTD
2,688,156
1.08
12
COMMONWEALTH SCIENTIFIC & INDUSTRIAL RESEARCH 
ORGANISATION 
2,500,000
1.01
13
MS NATALIE LOUISE PATTERSON
2,477,083
1.00
14
E & W NOMINEE PTY LTD
2,207,941
0.89
15
MR DANIEL EDDINGTON & MRS JULIE EDDINGTON
2,123,532
0.85
16
MR WEI FENG & MRS JIE LIU
2,050,215
0.82
17
MRS JOAN MARGARET MOLYNEUX & MRS WENDY ANNE HUTCHISON & 
MR JOHN EDWARD HUTCHISON
2,000,000
0.80
18
ARDROY SECURITIES PTY LTD
1,857,040
0.75
19
BNP PARIBAS NOMINEES PTY LTD ACF CLEARSTREAM
1,775,214
0.71
20
MRS LINDA JANE LOCKETT & DR TREVOR JOHN LOCKETT
1,678,300
0.68
Total
106,924,996
43.01
Balance of register
141,671,754
56.99
Grand total
248,596,750
100.00
53
ADDITIONAL ASX INFORMATION

Distribution Schedule
The following is a distribution schedule of the number of holders of fully paid ordinary shares in the Company, within the 
bands of holding specified by the ASX Listing Rules:
Range
No. of Shareholders
No. of Ordinary Shares
Percentage of Total 
Issued Capital
100,001 and Over
295
199,177,798
80.12
10,001 to 100,000
1,213
40,929,699
16.46
5,001 to 10,000
595
4,720,757
1.90
1,001 to 5,000
1,199
3,260,232
1.31
1 to 1,000
1,028
508,264
0.21
Total
4,330
248,596,750
100.00
2,439 shareholders held less than a marketable parcel of fully paid ordinary shares.
Substantial Shareholdings Register
Shareholder
Number of fully paid ordinary shares
Percentage of Total Issued Capital
Otto Buttula
36,384,575
14.64%
Adrien Wing
18,117,500
7.29%
A substantial holder is a shareholder who either alone or `together with their associates has an interest in 5% or more of 
the voting shares of the Company. 
Listed Options Over Ordinary Shares
Rhythm Biosciences Ltd Options are quoted on the Australian Securities Exchange (ASX) under the ticker code RHYO. 
The Company has issued 13,727,168 listed Options with an exercise price of $0.20 each expiring on 31 March 2026. 
The following information was extracted from the Company’s records as at 15 August 2024 and is required by the ASX 
Listing Rules. Rhythm’s securities are not quoted on any other stock exchange. 
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
54
ADDITIONAL ASX INFORMATION

Twenty Largest Holders of Listed Options
Rank
Holder
Number of 
Options
Percentage of Total 
Issued Capital
1
NEWFOUND INVESTMENTS PTY LTD
2,831,250
20.63
2
WEBINVEST PTY LTD
2,593,751
18.90
3
MR MARK ANTHONY ROGERS & MR ARTHUR NICHOLAS VELISS
500,000
3.64
4
MR BRIAN LEEDMAN & MRS NATASHA LEEDMAN
500,000
3.64
5 
JD'S FAMILY LG'S PTY LTD
344,001
2.51
6
MRS SARAH CAMERON
288,120
2.10
7
MR ARTHUR NICHOLAS VELISS & MR MARK ANTHONY ROGERS
255,000
1.86
8
MARBEX PTY LTD
250,001
1.82
9
WARWICK DAVID SMYTH
250,000
1.82
10
LARRAKEYAH PTY LIMITED
250,000
1.82
11
MRS JOAN MARGARET MOLYNEUX & MRS WENDY ANNE 
HUTCHISON & MR JOHN EDWARD HUTCHISON
250,000
1.82
12
MR SCOTT CRANK & MS LOLA CRANK
200,001
1.46
13
MRS LINDA JANE LOCKETT & DR TREVOR JOHN LOCKETT
193,650
1.41
14
MR PETER GEOFFREY HENDERSON
160,500
1.17
15
DR SCOTT MAURICE DONNELLAN
156,000
1.14
16
SIGGY2 PTY LTD
139,562
1.02
17
SULLIVAN CAPITAL HOLDINGS PTY LTD
135,000
0.98
18
SODOR INVESTMENTS PTY LTD
125,000
0.91
19
TERCUS PTY LTD
124,500
0.91
20
MR JON DAVID HEWITT & MRS DONNA RAE HEWITT
119,210
0.87
Total
9,665,546
70.41
Balance of register
4,061,622
29.59
Grand total
13,727,168
100.00
55

RHYO
Range
No. of Holders
No. of Options
Percentage of Total 
Issued Options
100,001 and Over
26
10,296,114
75.00
10,001 to 100,000
94
2,758,532
20.09
5,001 to 10,000
43
294,697
2.15
1,001 to 5,000
133
330,223
2.41
1 to 1,000
138
47,602
0.35
Total
434
13,727,168
100.00
Rhythm has granted unlisted options which entitles the holder to purchase one ordinary share in the Company at a 
predetermined price. No voting rights attach to options. Further details of options outstanding as at 15 August 2024 
are provided below:
Share Option Type
Expiry Date 
Number of Options
Number of Holders
Exercise Price $
RHYAN
30/11/25
200,000
1
1.80
RHYAP
31/03/26
2,000,000
1
0.20
RHYAQ
31/03/28
2,000,000
1
0.30
Escrow Arrangements
There are no shares subject to mandatory escrow arrangements.
Voting Rights
The voting rights attached to ordinary shares are set out below:
Ordinary shares:
On a show of hands every member present at a meeting in person or by proxy shall have one vote and upon a poll each 
share shall have one vote.
There are no other classes of equity securities.
RHYTHM BIOSCIENCES   
2024  ANNUAL REPORT
56
ADDITIONAL ASX INFORMATION

Directors
Mr Otto Buttula
Ms Susan MacLeman
Dr Trevor Lockett
Mr Louis (Lou) Panaccio 
Company Secretaries
Ms Andrea Steele
Mr James Barrie
Registered and Principal Office is located at
Bio21 Institute
30 Flemington Road
Parkville VIC 3010
Auditor
BDO Audit Pty Ltd
Level 18
727 Collins Street
Melbourne VIC 3000
Legal Advisers
K & L Gates
Level 25
525 Collins Street
Melbourne VIC 3000
Share Registry
Automic Registry Services
477 Collins Street
Melbourne VIC 3000
www.automicgroup.com.au
57
CORPORATE DIRECTORY

Rhythm Biosciences Limited 
ACN 619 459 335
Bio21 Institute
30 Flemington Road
Parkville VIC 3010 
Phone +61 3 8256 2880 
rhythmbio.com
RHYZ025 09/24